The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LR42-1" ], "evidence": [ { "id": "R-BTA-8955030", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8955030" } ] }, { "id": "R-BTA-9838081", "name": "LONP1 degrades mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "Q2KIE6-1", "P15690-1", "P20000-1", "Q32LG3-1", "P20004-1", "A0AAA9S896-1", "P00829-1", "Q5EAD4-1", "Q2TBR0-1", "F1MTT7-1", "Q148N0-1", "P11181-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q0NXR6-1", "Q29RZ0-1", "F1MXW5-1", "F1N338-1", "G3MWG4-1", "A0A140T871-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "O02691-1", "A0A3Q1LR42-1", "Q3ZCH0-1" ], "evidence": [ { "id": "R-BTA-9838081", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838081" } ] }, { "id": "R-BTA-9838093", "name": "LONP1 binds mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "Q2KIE6-1", "P15690-1", "P20000-1", "Q32LG3-1", "P20004-1", "A0AAA9S896-1", "P00829-1", "Q5EAD4-1", "Q2TBR0-1", "F1MTT7-1", "Q148N0-1", "P11181-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q0NXR6-1", "Q29RZ0-1", "F1MXW5-1", "F1N338-1", "G3MWG4-1", "A0A140T871-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "O02691-1", "A0A3Q1LR42-1", "Q3ZCH0-1" ], "evidence": [ { "id": "R-BTA-9838093", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838093" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T871", "gene_name": "GLUD1", "activity": [ { "ec_number": "1.4.1.3", "activity": "L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+).", "evidence": [ { "id": "A0A140T871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T871" } ] }, { "ec_number": "1.4.1.3", "activity": "", "evidence": [ { "id": "A0A140T871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T871" } ] } ] }, { "uniprot_ac": "A0A3Q1LR42", "gene_name": "NADK2", "activity": [ { "ec_number": "2.7.1.23", "activity": "NAD(+) + ATP = ADP + NADP(+) + H(+).", "evidence": [ { "id": "A0A3Q1LR42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR42" } ] }, { "ec_number": "2.7.1.23", "activity": "", "evidence": [ { "id": "A0A3Q1LR42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR42" } ] } ] }, { "uniprot_ac": "A0A3Q1LS03", "gene_name": "", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0A3Q1LS03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "A0A3Q1LS03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ] } ] }, { "uniprot_ac": "A0A3Q1LS67", "gene_name": "ECH1", "activity": [ { "ec_number": "5.3.3.21", "activity": "a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA.", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] }, { "ec_number": "5.3.3.21", "activity": "", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] } ] }, { "uniprot_ac": "A0A3Q1LYU1", "gene_name": "PDK1", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "A0A3Q1LYU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ] } ] }, { "uniprot_ac": "A0AAA9S896", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "A0AAA9S896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S896" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "A0AAA9S896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S896" } ] } ] }, { "uniprot_ac": "F1MCL6", "gene_name": "NADK", "activity": [ { "ec_number": "2.7.1.23", "activity": "NAD(+) + ATP = ADP + NADP(+) + H(+).", "evidence": [ { "id": "F1MCL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCL6" } ] }, { "ec_number": "2.7.1.23", "activity": "", "evidence": [ { "id": "F1MCL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCL6" } ] } ] }, { "uniprot_ac": "F1MTT7", "gene_name": "ECI1", "activity": [ { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "F1MTT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTT7" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "F1MTT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTT7" } ] } ] }, { "uniprot_ac": "F1MXW5", "gene_name": "OXSM", "activity": [ { "ec_number": "2.3.1.41", "activity": "a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2.", "evidence": [ { "id": "F1MXW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXW5" } ] }, { "ec_number": "2.3.1.41", "activity": "", "evidence": [ { "id": "F1MXW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXW5" } ] } ] }, { "uniprot_ac": "F1N338", "gene_name": "HADH", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ] } ] }, { "uniprot_ac": "G3MWG4", "gene_name": "IARS2", "activity": [ { "ec_number": "6.1.1.5", "activity": "tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate.", "evidence": [ { "id": "G3MWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWG4" } ] }, { "ec_number": "6.1.1.5", "activity": "", "evidence": [ { "id": "G3MWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWG4" } ] } ] }, { "uniprot_ac": "G3MWN1", "gene_name": "ARG2", "activity": [ { "ec_number": "3.5.3.1", "activity": "L-arginine + H2O = urea + L-ornithine.", "evidence": [ { "id": "G3MWN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWN1" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "G3MWN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWN1" } ] } ] }, { "uniprot_ac": "G3N0R5", "gene_name": "HSPD1", "activity": [ { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "G3N0R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0R5" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "G3N0R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0R5" } ] } ] }, { "uniprot_ac": "O02691", "gene_name": "HSD17B10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.239", "activity": "testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.53", "activity": "androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] } ] }, { "uniprot_ac": "P00829", "gene_name": "ATP5F1B", "activity": [ { "ec_number": "7.1.2.2", "activity": "ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out).", "evidence": [ { "id": "P00829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00829" } ] }, { "ec_number": "7.1.2.2", "activity": "", "evidence": [ { "id": "P00829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00829" } ] } ] }, { "uniprot_ac": "P11181", "gene_name": "DBT", "activity": [ { "ec_number": "2.3.1.168", "activity": "(2S)-2-methylbutanoyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] = N(6)-{(R)-S(8)-[(2S)-2-methylbutanoyl]dihydrolipoyl}-L-lysyl-[protein] + CoA.", "evidence": [ { "id": "P11181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11181" } ] }, { "ec_number": "2.3.1.168", "activity": "", "evidence": [ { "id": "P11181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11181" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P11181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11181" } ] } ] }, { "uniprot_ac": "P11966", "gene_name": "PDHB", "activity": [ { "ec_number": "1.2.4.1", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "P11966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11966" } ] }, { "ec_number": "1.2.4.1", "activity": "", "evidence": [ { "id": "P11966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11966" } ] } ] }, { "uniprot_ac": "P15690", "gene_name": "NDUFS1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] } ] }, { "uniprot_ac": "P20000", "gene_name": "ALDH2", "activity": [ { "ec_number": "1.2.1.3", "activity": "acetaldehyde + NAD(+) + H2O = acetate + NADH + 2 H(+).", "evidence": [ { "id": "P20000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20000" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P20000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20000" } ] } ] }, { "uniprot_ac": "P20004", "gene_name": "ACO2", "activity": [ { "ec_number": "4.2.1.3", "activity": "citrate = D-threo-isocitrate.", "evidence": [ { "id": "P20004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20004" } ] }, { "ec_number": "4.2.1.3", "activity": "", "evidence": [ { "id": "P20004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20004" } ] } ] }, { "uniprot_ac": "P22600", "gene_name": "FECH", "activity": [ { "ec_number": "4.98.1.1", "activity": "heme b + 2 H(+) = protoporphyrin IX + Fe(2+).", "evidence": [ { "id": "P22600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P22600" } ] }, { "ec_number": "4.98.1.1", "activity": "", "evidence": [ { "id": "P22600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P22600" } ] } ] }, { "uniprot_ac": "Q0NXR6", "gene_name": "ACAD8", "activity": [ { "ec_number": "1.3.8.5", "activity": "2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "Q0NXR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0NXR6" } ] }, { "ec_number": "1.3.8.5", "activity": "", "evidence": [ { "id": "Q0NXR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0NXR6" } ] } ] }, { "uniprot_ac": "Q148N0", "gene_name": "OGDH", "activity": [ { "ec_number": "1.2.4.2", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "Q148N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148N0" } ] }, { "ec_number": "1.2.4.2", "activity": "", "evidence": [ { "id": "Q148N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148N0" } ] } ] }, { "uniprot_ac": "Q29RK1", "gene_name": "CS", "activity": [ { "ec_number": "2.3.3.1", "activity": "oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+).", "evidence": [ { "id": "Q29RK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RK1" } ] }, { "ec_number": "2.3.3.1", "activity": "", "evidence": [ { "id": "Q29RK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RK1" } ] } ] }, { "uniprot_ac": "Q29RZ0", "gene_name": "ACAT1", "activity": [ { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "Q29RZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ0" } ] }, { "ec_number": "2.3.1.9", "activity": "", "evidence": [ { "id": "Q29RZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ0" } ] } ] }, { "uniprot_ac": "Q2KIE6", "gene_name": "HMGCS2", "activity": [ { "ec_number": "2.3.3.10", "activity": "acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).", "evidence": [ { "id": "Q2KIE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIE6" } ] }, { "ec_number": "2.3.3.10", "activity": "", "evidence": [ { "id": "Q2KIE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIE6" } ] } ] }, { "uniprot_ac": "Q2TBR0", "gene_name": "PCCB", "activity": [ { "ec_number": "6.4.1.3", "activity": "propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBR0" } ] }, { "ec_number": "6.4.1.3", "activity": "", "evidence": [ { "id": "Q2TBR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBR0" } ] } ] }, { "uniprot_ac": "Q32LG3", "gene_name": "MDH2", "activity": [ { "ec_number": "1.1.1.37", "activity": "(S)-malate + NAD(+) = oxaloacetate + NADH + H(+).", "evidence": [ { "id": "Q32LG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LG3" } ] }, { "ec_number": "1.1.1.37", "activity": "", "evidence": [ { "id": "Q32LG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LG3" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { 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"field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LR60-1", "uniprot_ac": "A0A3Q1LR60", "uniprot_id": "A0A3Q1LR60_BOVIN", "mass": { "chemical_mass": 77320.0, "monoisotopic_mass": 77320.0 }, "refseq": { "ac": "NP_001193365", "name": "GMP synthase [glutamine-hydrolyzing]", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193365" }, "gene_names": [ { "name": "GMPS", "type": "recommended", "evidence": [ { "id": "A0A3Q1LR60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60" } ] }, { "name": "GMPS", "type": "synonym", "evidence": [ { "id": "NP_001193365", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193365" } ] } ], "protein_names": [ { "name": "GMP synthase [glutamine-hydrolyzing]", "type": "recommended", "evidence": [ { "id": "A0A3Q1LR60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60/entry#names_and_taxonomy" } ] }, { "name": "6.3.5.2", "type": "synonym", "evidence": [ { "id": "A0A3Q1LR60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60/entry#names_and_taxonomy" } ] }, { "name": "GMP synthase [glutamine-hydrolyzing]", "type": "synonym", "evidence": [ { "id": "NP_001193365", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193365" } ] }, { "name": "GMP synthetase", "type": "synonym", "evidence": [ { "id": "A0A3Q1LR60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60/entry#names_and_taxonomy" } ] }, { "name": "Glutamine amidotransferase", "type": "synonym", "evidence": [ { "id": "A0A3Q1LR60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60/entry#names_and_taxonomy" } ] }, { "name": "guanine monophosphate synthetase", "type": "synonym", "evidence": [ { "id": "NP_001193365", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193365" } ] } ], "function": [ { "annotation": "Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR60", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60#function" }, { "database": "UniProtKB", "id": "ARBA00044933", "url": "https://www.uniprot.org/uniprotkb/ARBA00044933#function" }, { "database": "UniProtKB", "id": "A0A3Q1LUN6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUN6#function" }, { "database": "UniProtKB", "id": "F1MC86", "url": "https://www.uniprot.org/uniprotkb/F1MC86#function" }, { "database": "UniProtKB", "id": "A0AAA9S6Y7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Y7#function" }, { "database": "UniProtKB", "id": "A0AAA9TDU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR60", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GMPS", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60", "locus": { "chromosome": "1", "start_pos": 111677371, "end_pos": 111804777, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013013", "url": "https://www.ensembl.org/id/ENSBTAG00000013013" } ] } } ], "crossref": [ { "id": "A0A3Q1LR60", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LR60", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013013", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013013", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01742", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01742", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01997", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01997", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511200", "url": "https://www.ncbi.nlm.nih.gov/gene/511200", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022310", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022310", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025777", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025777", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029062", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029062", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511200", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511200", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LR60", "url": "https://www.orthodb.org/?gene=A0A3Q1LR60", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUN6", "url": "https://www.orthodb.org/?gene=A0A3Q1LUN6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MC86", "url": "https://www.orthodb.org/?gene=F1MC86", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11922", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11922", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11922:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11922:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00117", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00117", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00958", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00958", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02540", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02540", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-73817", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73817", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9748787", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9748787", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193365", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11680", "url": "https://www.rhea-db.org/rhea/11680", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LR60", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LR60-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUN6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUN6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6Y7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Y7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6Y7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Y7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1Z4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Z4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1Z4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Z4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDU5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC86", "url": "https://www.uniprot.org/uniprotkb/F1MC86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC86-1", "url": "https://www.uniprot.org/uniprotkb/F1MC86-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALDSSSIHFSPQKKLENAGGDLKDGHHHNEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFSISVDNTCSLFRGLQKEEIVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNREIECIREIKEGVGTSKVLVLLSGGVDSTVCTALLNRALNQDQVIAVHIDNGFMRKRESQSVEEALRKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNINRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE", "length": 699, "header": "tr|A0A3Q1LR60-1|A0A3Q1LR60_BOVIN Isoform 1 of GMP synthase [glutamine-hydrolyzing] OS=Bos taurus OX=9913 GN=GMPS PE=4 SV=1 CANONICAL=A0A3Q1LR60-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LR60-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60/entry", "sequence": { "sequence": "MALDSSSIHFSPQKKLENAGGDLKDGHHHNEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFSISVDNTCSLFRGLQKEEIVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNREIECIREIKEGVGTSKVLVLLSGGVDSTVCTALLNRALNQDQVIAVHIDNGFMRKRESQSVEEALRKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNINRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE", "length": 699, "header": "tr|A0A3Q1LR60-1|A0A3Q1LR60_BOVIN Isoform 1 of GMP synthase [glutamine-hydrolyzing] OS=Bos taurus OX=9913 GN=GMPS PE=4 SV=1 CANONICAL=A0A3Q1LR60-1" }, "locus": { "chromosome": "1", "start_pos": 111804763, "end_pos": 111732921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069914.1", "url": "https://www.ensembl.org/id/ENSBTAT00000069914.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057515.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057515.1" } ] } }, { "isoform_ac": "A0A3Q1LUN6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUN6/entry", "sequence": { "sequence": "MALCNGDSKISSHLLRYSPRLEKLLQTKRMLENAGGDLKDGHHHNEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFSISVDNTCSLFRGLQKEEIVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNREIECIREIKEGVGTSKVLVLLSGGVDSTVCTALLNRALNQDQVIAVHIDNGFMRKRESQSVEEALRKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNINRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE", "length": 714, "header": "tr|A0A3Q1LUN6-1|A0A3Q1LUN6_BOVIN Computationally mapped isoform of GMP synthase [glutamine-hydrolyzing] OS=Bos taurus OX=9913 GN=GMPS PE=4 SV=2 CANONICAL=A0A3Q1LR60-1" }, "locus": { "chromosome": "1", "start_pos": 111803238, "end_pos": 111732921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084984.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084984.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064263.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064263.2" } ] } }, { "isoform_ac": "A0AAA9S6Y7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Y7/entry", "sequence": { "sequence": "MRPHHPLENAGGDLKDGHHHNEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFSISVDNTCSLFRGLQKEEIVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNREIECIREIKEGVGTSKVLVLLSGGVDSTVCTALLNRALNQDQVIAVHIDNGFMRKRESQSVEEALRKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNINRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE", "length": 690, "header": "tr|A0AAA9S6Y7-1|A0A3Q1LR60_BOVIN Computationally mapped isoform of GMP synthase [glutamine-hydrolyzing] OS=Bos taurus OX=9913 GN=GMPS PE=4 SV=1 CANONICAL=A0A3Q1LR60-1" }, "locus": { "chromosome": "1", "start_pos": 111804006, "end_pos": 111732921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122988.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122988.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077935.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077935.1" } ] } }, { "isoform_ac": "A0AAA9T1Z4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1Z4/entry", "sequence": { "sequence": "MALCNGDSKLENAGGDLKDGHHHNEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFSISVDNTCSLFRGLQKEEIVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNREIECIREIKEGVGTSKVLVLLSGGVDSTVCTALLNRALNQDQVIAVHIDNGFMRKRESQSVEEALRKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNINRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVLV", "length": 663, "header": "tr|A0AAA9T1Z4-1|A0A3Q1LR60_BOVIN Computationally mapped isoform of GMP synthase [glutamine-hydrolyzing] OS=Bos taurus OX=9913 GN=GMPS PE=4 SV=1 CANONICAL=A0A3Q1LR60-1" }, "locus": { "chromosome": "1", "start_pos": 111803238, "end_pos": 111678375, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121384.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121384.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090629.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090629.1" } ] } }, { "isoform_ac": "A0AAA9TDU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU5/entry", "sequence": { "sequence": "MALCNGDSKMMNKVFGGTVHKKSVREDGVFSISVDNTCSLFRGLQKEEIVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNREIECIREIKEGVGTSKVLVLLSGGVDSTVCTALLNRALNQDQVIAVHIDNGFMRKRESQSVEEALRKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNINRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE", "length": 594, "header": "tr|A0AAA9TDU5-1|A0A3Q1LR60_BOVIN Computationally mapped isoform of GMP synthase [glutamine-hydrolyzing] OS=Bos taurus OX=9913 GN=GMPS PE=4 SV=1 CANONICAL=A0A3Q1LR60-1" }, "locus": { "chromosome": "1", "start_pos": 111803238, "end_pos": 111732921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101326.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101326.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094329.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094329.1" } ] } }, { "isoform_ac": "F1MC86-1", "url": "https://www.uniprot.org/uniprotkb/F1MC86/entry", "sequence": { "sequence": "MRTLHCTCTSTEYQAKPWQKLENAGGDLKDGHHHNEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFSISVDNTCSLFRGLQKEEIVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNREIECIREIKEGVGTSKVLVLLSGGVDSTVCTALLNRALNQDQVIAVHIDNGFMRKRESQSVEEALRKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNINRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE", "length": 704, "header": "tr|F1MC86-1|F1MC86_BOVIN Computationally mapped isoform of GMP synthase [glutamine-hydrolyzing] OS=Bos taurus OX=9913 GN=GMPS PE=4 SV=4 CANONICAL=A0A3Q1LR60-1" }, "locus": { "chromosome": "1", "start_pos": 111798063, "end_pos": 111732921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017301.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017301.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017301.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017301.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 658, "start_aa": "Thr", "end_pos": 658, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr658", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:511200", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511200", "resource": "KEGG Pathway" }, { "id": "R-BTA-73817", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73817", "resource": "Reactome", "description": "Purine ribonucleoside monophosphate biosynthesis" }, { "id": "R-BTA-9748787", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9748787", "resource": "Reactome", "description": "Azathioprine ADME" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR60", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60" } ], "pmid": "" }, { "name": "GMP synthase activity", "id": "GO:0003921", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003921", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR60", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR60", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "GMP biosynthetic process", "id": "GO:0006177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006177", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR60", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 334, "end_pos": 336, "annotation": "n_glycosylation_sequon" }, { "start_pos": 399, "end_pos": 401, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11680", "name": "", "equation": "XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LR60-1" ], "evidence": [ { "id": "11680", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11680" } ] }, { "id": "R-BTA-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-111584" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LR60-1" ], "evidence": [ { "id": "R-BTA-73792", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73792" } ] }, { "id": "R-BTA-9748957", "name": "GMPS dimer transforms 6TXMP to 6TGMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-9748959" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LR60-1" ], "evidence": [ { "id": "R-BTA-9748957", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9748957" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-111584", "participant_name": "XMP [cytosol]", "crossref": [ { "id": "57464", "database": "ChEBI", "url": "" }, { "id": "ZINC000004228292", "database": "ZINC", "url": "" }, { "id": "C00655", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-9748959", "participant_name": "6TXMP [cytosol]", "crossref": [ { "id": "180685", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LR60", "gene_name": "GMPS", "activity": [ { "ec_number": "6.3.5.2", "activity": "XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1LR60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60" } ] }, { "ec_number": "6.3.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LR60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LR60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR60" }, { "id": "PS51553", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51553" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GMPS ATP-PPase", "eco_id": "ECO_0000259", "start_pos": 223, "end_pos": 441, "start_aa": "Phe", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.3.5.2", "ec_name": "XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+).", "evidence": [ { "id": "6.3.5.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.2" }, { "id": "6.3.5.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.3.5.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 658 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 185, "end_pos": 187 }, { "start_pos": 311, "end_pos": 313 }, { "start_pos": 334, "end_pos": 336 }, { "start_pos": 399, "end_pos": 401 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTZ7/entry#names_and_taxonomy" } ] }, { "name": "Virus-encoded semaphorin protein receptor", "type": "synonym", "evidence": [ { "id": "A0A3Q1LTZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTZ7/entry#names_and_taxonomy" } ] }, { "name": "plexin-C1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059742393", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742393" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTZ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTZ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLXNC1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTZ7", "locus": { "chromosome": "5", "start_pos": 24071753, "end_pos": 23915576, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011245", "url": "https://www.ensembl.org/id/ENSBTAG00000011245" } ] } } ], "crossref": [ { "id": "ENSBTAG00000011245", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011245", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00102", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00102", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12789", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12789", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518168", "url": "https://www.ncbi.nlm.nih.gov/gene/518168", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046800", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518168", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518168", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ETPIFHR", "url": "https://omabrowser.org/oma/group/ETPIFHR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LR61", "url": "https://www.orthodb.org/?gene=A0A3Q1LR61", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LTZ7", "url": "https://www.orthodb.org/?gene=A0A3Q1LTZ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BDY7", "url": "https://www.orthodb.org/?gene=E1BDY7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22625", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22625", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22625:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22625:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01437", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01437", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01833", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01833", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08337", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08337", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20170", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20170", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059742393", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742393", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LR61", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LR61-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTZ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDY7", "url": "https://www.uniprot.org/uniprotkb/E1BDY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDY7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDY7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVSRRKVPPRPPRPAALLPLLAYLLALAAPGQGADEPVWRSEQAIGAIAVSREDGVFVASGSCLDQLDYSLEHRLSRLYRDQAGNCSEPVPLTPPARPRPGSSFSKLLLPYREGAAGLEGLLLTGWTFDRGACEVRPLGNLSRSSLRNGTEVVSCHPQGSTAGVVYYANDTQSWYLAVAATYVLPESETASRCNPAASDRETAIALKDTGKRSLATKETGRLKLRDGGGSLHFVDAFLWNGSVYFPYYPYNYSTGAATGWPSMARIAKSSEMLLFQGQAALNCGHGRPDGRRLLLSSSLVEALDVWAGVFSAATGEDQEKRSPTTTALCLFRMSEIQARTKICRWDFEIDNNENNCKNEDEPEKVEPIASSTLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILSENLASNCPEVIYEIKEETPVFYKLVPHPKKNIYIYLTAGKEVRRIRVANCGKHKSCWECLAATDPHCGWCHSLQRCTFKEDCEHLNNSENWLDVLSGAKKCPQIHLFRSSKDKTTVTVVGSFSPRHSECVVKNVDTGRMLCKGKSAHNETCTCIIPTRTAYKDVLVVNMTFSFGSWRVSKRFNFTNCSSLRECPGCIRTGCAWCKSERKCIHPFTACDPLDYKRNQDLCPVAFQKWTPPKTAGEGRFKENMSNRTTWGLQVFSVTSIEPQKISTLGKSNVTVTGANFTEASNITMILKGTSTCDKDVIQVSHVVNATHMQFSLPSSRKEMKDVCIQFDGGNCASVGPLSYVALPHCSLIYPATTWISGGQNITIMGRNFDVIDNLIFSQEVKEKNVSEYCMANSCRFLAPSLKSSKGPINVTVKLRVQETALDCGSLQYLDDPRFTGYRAESEVDTELEVKIQKENDNFNISKEDIEITLFYGKNKSLNCSFENITRNQDLTTIFCKIKHITAANSIATSSKKVDVKLGNLKLSVERESVLSPWYFLIGLPILLVFVIFVAVGVTRHKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSFGTVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDASDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVALTVTFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLELQVGTRHKELLDIDSSSVILEDGITKLNTIGHYEISNGSTIKVFKKIANFTSDVEYTEDHCHLILPDSEAFQDVQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIIKYFDEILNKLERERGLEEAQKQLLHVKVLFEEKKKCKWMCPAGDFTPSTITEE", "length": 1589, "header": "tr|A0A3Q1LTZ7-1|A0A3Q1LTZ7_BOVIN Isoform 1 of Plexin-C1 OS=Bos taurus OX=9913 GN=PLXNC1 PE=3 SV=2 CANONICAL=A0A3Q1LTZ7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LR61-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR61/entry", "sequence": { "sequence": "MEVSRRKVPPRPPRPAALLPLLAYLLALAAPGQGADEPVWRSEQAIGAIAVSREDGVFVASGSCLDQLDYSLEHRLSRLYRDQAGNCSEPVPLTPPARPRPGSSFSKLLLPYREGAAGLEGLLLTGWTFDRGACEVRPLGNLSRSSLRNGTEVVSCHPQGSTAGVVYYANDTQSWYLAVAATYVLPESETASRCNPAASDRETAIALKDTGKRSLATKETGRLKLRDGGGSLHFVDAFLWNGSVYFPYYPYNYSTGAATGWPSMARIAKSSEMLLFQGQAALNCGHGRPDGRRLLLSSSLVEALDVWAGVFSAATGEDQEKRSPTTTALCLFRMSEIQARTKICRWDFEIDNNENNCVILSENLASNCPEVIYEIKEETPVFYKLVPHPKKNIYIYLTAGKEVRRIRVANCGKHKSCWECLAATDPHCGWCHSLQRCTFKEDCEHLNNSENWLDVLSGAKKCPQIHLFRSSKDKTTVTVVGSFSPRHSECVVKNVDTGRMLCKGKSAHNETCTCIIPTRTAYKDVLVVNMTFSFGSWRVSKRFNFTNCSSLRECPGCIRTGCAWCKSERKCIHPFTACDPLDYKRNQDLCPVAFQKWTPPKTAGEGRFKENMSNRTTWGLQVFSVTSIEPQKISTLGKSNVTVTGANFTEASNITMILKGTSTCDKDVIQVSHVVNATHMQFSLPSSRKEMKDVCIQFDGGNCASVGPLSYVALPHCSLIYPATTWISGGQNITIMGRNFDVIDNLIFSQEVKEKNVSEYCMANSCRFLAPSLKSSKGPINVTVKLRVQETALDCGSLQYLDDPRFTGYRAESEVDTELEVKIQKENDNFNISKEDIEITLFYGKNKSLNCSFENITRNQDLTTIFCKIKHITAANSIATSSKKVDVKLGNLKLSVERESVLSPWYFLIGLPILLVFVIFVAVGVTRHKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSFGTVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDASDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVALTVTFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLELQVGTRHKELLDIDSSSVILEDGITKLNTIGHYEISNGSTIKVFKKIANFTSDVEYTEDHCHLILPDSEAFQDVQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIIKYFDEILNKLERERGLEEAQKQLLHVKVLFEEKKKCKWM", "length": 1528, "header": "tr|A0A3Q1LR61-1|A0A3Q1LTZ7_BOVIN Computationally mapped isoform of Plexin-C1 OS=Bos taurus OX=9913 GN=PLXNC1 PE=3 SV=1 CANONICAL=A0A3Q1LTZ7-1" }, "locus": { "chromosome": "5", "start_pos": 24066586, "end_pos": 23915775, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074218.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074218.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059604.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059604.1" } ] } }, { "isoform_ac": "A0A3Q1LTZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTZ7/entry", "sequence": { "sequence": "MEVSRRKVPPRPPRPAALLPLLAYLLALAAPGQGADEPVWRSEQAIGAIAVSREDGVFVASGSCLDQLDYSLEHRLSRLYRDQAGNCSEPVPLTPPARPRPGSSFSKLLLPYREGAAGLEGLLLTGWTFDRGACEVRPLGNLSRSSLRNGTEVVSCHPQGSTAGVVYYANDTQSWYLAVAATYVLPESETASRCNPAASDRETAIALKDTGKRSLATKETGRLKLRDGGGSLHFVDAFLWNGSVYFPYYPYNYSTGAATGWPSMARIAKSSEMLLFQGQAALNCGHGRPDGRRLLLSSSLVEALDVWAGVFSAATGEDQEKRSPTTTALCLFRMSEIQARTKICRWDFEIDNNENNCKNEDEPEKVEPIASSTLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILSENLASNCPEVIYEIKEETPVFYKLVPHPKKNIYIYLTAGKEVRRIRVANCGKHKSCWECLAATDPHCGWCHSLQRCTFKEDCEHLNNSENWLDVLSGAKKCPQIHLFRSSKDKTTVTVVGSFSPRHSECVVKNVDTGRMLCKGKSAHNETCTCIIPTRTAYKDVLVVNMTFSFGSWRVSKRFNFTNCSSLRECPGCIRTGCAWCKSERKCIHPFTACDPLDYKRNQDLCPVAFQKWTPPKTAGEGRFKENMSNRTTWGLQVFSVTSIEPQKISTLGKSNVTVTGANFTEASNITMILKGTSTCDKDVIQVSHVVNATHMQFSLPSSRKEMKDVCIQFDGGNCASVGPLSYVALPHCSLIYPATTWISGGQNITIMGRNFDVIDNLIFSQEVKEKNVSEYCMANSCRFLAPSLKSSKGPINVTVKLRVQETALDCGSLQYLDDPRFTGYRAESEVDTELEVKIQKENDNFNISKEDIEITLFYGKNKSLNCSFENITRNQDLTTIFCKIKHITAANSIATSSKKVDVKLGNLKLSVERESVLSPWYFLIGLPILLVFVIFVAVGVTRHKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSFGTVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDASDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVALTVTFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLELQVGTRHKELLDIDSSSVILEDGITKLNTIGHYEISNGSTIKVFKKIANFTSDVEYTEDHCHLILPDSEAFQDVQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIIKYFDEILNKLERERGLEEAQKQLLHVKVLFEEKKKCKWMCPAGDFTPSTITEE", "length": 1589, "header": "tr|A0A3Q1LTZ7-1|A0A3Q1LTZ7_BOVIN Isoform 1 of Plexin-C1 OS=Bos taurus OX=9913 GN=PLXNC1 PE=3 SV=2 CANONICAL=A0A3Q1LTZ7-1" }, "locus": { "chromosome": "5", "start_pos": 24071351, "end_pos": 23915775, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074109.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074109.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063972.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063972.2" } ] } }, { "isoform_ac": "E1BDY7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDY7/entry", "sequence": { "sequence": "MEVSRRKVPPRPPRPAALLPLLAYLLALAAPGQGADEPVWRSEQAIGAIAVSREDGVFVASGSCLDQLDYSLEHRLSRLYRDQAGNCSEPVPLTPPARPRPGSSFSKLLLPYREGAAGLEGLLLTGWTFDRGACEVRPLGNLSRSSLRNGTEVVSCHPQGSTAGVVYYANDTQSWYLAVAATYVLPESETASRCNPAASDRETAIALKDTGKRSLATKETGRLKLRDGGGSLHFVDAFLWNGSVYFPYYPYNYSTGAATGWPSMARIAKSSEMLLFQGQAALNCGHGRPDGRRLLLSSSLVEALDVWAGVFSAATGEDQEKRSPTTTALCLFRMSEIQARTKICRWDFEIDNNENNCKNEDEPEKVEPIASSTLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILSENLASNCPEVIYEIKEETPVFYKLVPHPKKNIYIYLTAGKEVRRIRVANCGKHKSCWECLAATDPHCGWCHSLQRCTFKEDCEHLNNSENWLDVLSGAKKCPQIHLFRSSKDKTTVTVVGSFSPRHSECVVKNVDTGRMLCKGKSAHNETCTCIIPTRTAYKDVLVVNMTFSFGSWRVSKRFNFTNCSSLRECPGCIRTGCAWCKSERKCIHPFTACDPLDYKRNQDLCPVAFQKWTPPKTAGEGRFKENMSNRTTWGLQVFSVTSIEPQKISTLGKSNVTVTGANFTEASNITMILKGTSTCDKDVIQVSHVVNATHMQFSLPSSRKEMKDVCIQFDGGNCASVGPLSYVALPHCSLIYPATTWISGGQNITIMGRNFDVIDNLIFSQEVKEKNVSEYCMANSCRFLAPSLKSSKGPINVTVKLRVQETALDCGSLQYLDDPRFTGYRAESEVDTELEVKIQKENDNFNISKEDIEITLFYGKNKSLNCSFENITRNQDLTTIFCKIKHITAANSIATSSKKVDVKLGNLKLSVERESVLSPWYFLIGLPILLVFVIFVAVGVTRHKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSFGTVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDASDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVALTVTFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLELQVGTRHKELLDIDSSSVILEDGITKLNTIGHYEISNGSTIKVFKKIANFTSDVEYTEDHCHLILPDSEAFQDVQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIIKYFDEILNKLERERGLEEAQKQLLHVKVLFEEKKKCKWM", "length": 1575, "header": "tr|E1BDY7-1|A0A3Q1LTZ7_BOVIN Computationally mapped isoform of Plexin-C1 OS=Bos taurus OX=9913 GN=PLXNC1 PE=3 SV=2 CANONICAL=A0A3Q1LTZ7-1" }, "locus": { "chromosome": "5", "start_pos": 24066586, "end_pos": 23915775, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014932.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014932.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014932.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014932.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518168", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518168", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A7M0-1", "protein_name": "Plexin-C1", "gene_name": "Plxnc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVSRRKAPPRPPYPAAPLPLIAYLLALAVPARGADEPVWRSEQAIGAIAASRADGVFVASGSCLDQLDYSLKNRLSRLYRDQAGNCTEPVSLAPPARPRPGSSFSKLLLPYREGATGLEGLLLTGWTFDRGACEVRPLGNLNRSSLRNGTEVVSCHPQGSTAGVVYRASGTDLWYLAVAATYVLPEPETANRCNPAASDRDTAIALKNTEGRSLATQELGRLKLRGSAGSLHFVDAFLWNGSVYFPYYPYNYTSGAATGWPSMARIAQSTEVLFQGQAALDCGHGHPEGRRLLLSSSLVEAVDIWAGVFSAATGEGQEKRSPATTALCLFRMSEIQARARSCSWDFQATEHNCKEGDQPEQVQPIASSTLIHSDLTSVYGTVVMNRIVLFLGTGDGQLLKVVLGENLTSNCPEVIYEIKEETPVFYKLVPHPVKDTYIYLTAGKEVRRIQVANCSKRKSCFQCLAAADPHCGWCLPLQRSSFMGGGDAVRHFLNWRSMAEGPHHTPKSQWSKALKERTTVTIVGSVSARHSECVVKNADTGKLLCQGRSQMNRTCACNIPSRPSNNVFVVNATFTFPSWSVSERFNFTNCASVRECPACIETGCAWCKRDKRCIHPFTPCEPSDYERNQELCHVAVEKPPKDSGGGRVKESKRNRTDPALQVFYIKAIEPQKISTLGKSNVIVTGANFTQASNITMILRGTSTCEKDVIRVSHVLNDTHMKFSLPSSRKEMKDVCIQFDGGNCSSAGALSYIALPHCSLIVPATTWISGGQNITIMGRNFDVIDNLIISHELKGNINVSINVSEYCMATSCRFLAPNLKSSKGRTNVVVKLRVQDTYLDCGTLQYLEDPRFTGYRVESEIDTELEVKIQKENDNFNISRDDIDITLFHGENKQFNCSFENITRNQDLTTILCKIKSIKNANTIATSSKKVRVKLGNLELYVEQESVPSTWYFLIALPILLAIVIVVAVVVTRHKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSFGTVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFNTVALNVVFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLELQVGTRQKELLDIDSSSVILEDGITKLNTIGHYEISNGSTIKVFKKIANFTSDVEYSDDHCHLILPDSEAFQVVQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDSCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLPPLSSLEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQKQLLHVKVLFDEKKKCKWM", "length": 1574 }, "evidence": [ { "id": "A0A3Q1LTZ7", "url": "https://omabrowser.org/oma/group/A0A3Q1LTZ7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SQN2-1", "protein_name": "Plexin-C1", "gene_name": "PLXNC1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": 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"length": 1570 }, "evidence": [ { "id": "A0A3Q1LTZ7", "url": "https://omabrowser.org/oma/group/A0A3Q1LTZ7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O60486-1", "protein_name": "Plexin-C1", "gene_name": "PLXNC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEVSRRKAPPRPPRPAAPLPLLAYLLALAAPGRGADEPVWRSEQAIGAIAASQEDGVFVASGSCLDQLDYSLEHSLSRLYRDQAGNCTEPVSLAPPARPRPGSSFSKLLLPYREGAAGLGGLLLTGWTFDRGACEVRPLGNLSRNSLRNGTEVVSCHPQGSTAGVVYRAGRNNRWYLAVAATYVLPEPETASRCNPAASDHDTAIALKDTEGRSLATQELGRLKLCEGAGSLHFVDAFLWNGSIYFPYYPYNYTSGAATGWPSMARIAQSTEVLFQGQASLDCGHGHPDGRRLLLSSSLVEALDVWAGVFSAAAGEGQERRSPTTTALCLFRMSEIQARAKRVSWDFKTAESHCKEGDQPERVQPIASSTLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIKEETPVFYKLVPDPVKNIYIYLTAGKEVRRIRVANCNKHKSCSECLTATDPHCGWCHSLQRCTFQGDCVHSENLENWLDISSGAKKCPKIQIIRSSKEKTTVTMVGSFSPRHSKCMVKNVDSSRELCQNKSQPNRTCTCSIPTRATYKDVSVVNVMFSFGSWNLSDRFNFTNCSSLKECPACVETGCAWCKSARRCIHPFTACDPSDYERNQEQCPVAVEKTSGGGRPKENKGNRTNQALQVFYIKSIEPQKVSTLGKSNVIVTGANFTRASNITMILKGTSTCDKDVIQVSHVLNDTHMKFSLPSSRKEMKDVCIQFDGGNCSSVGSLSYIALPHCSLIFPATTWISGGQNITMMGRNFDVIDNLIISHELKGNINVSEYCVATYCGFLAPSLKSSKVRTNVTVKLRVQDTYLDCGTLQYREDPRFTGYRVESEVDTELEVKIQKENDNFNISKKDIEITLFHGENGQLNCSFENITRNQDLTTILCKIKGIKTASTIANSSKKVRVKLGNLELYVEQESVPSTWYFLIVLPVLLVIVIFAAVGVTRHKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSFGTVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVALNVVFEKIPENESADVCRNISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLELQMGTRQKELLDIDSSSVILEDGITKLNTIGHYEISNGSTIKVFKKIANFTSDVEYSDDHCHLILPDSEAFQDVQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQKQLLHVKVLFDEKKKCKWM", "length": 1568 }, "evidence": [ { "id": "A0A3Q1LTZ7", "url": "https://omabrowser.org/oma/group/A0A3Q1LTZ7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QZC2-1", "protein_name": "Plexin-C1", "gene_name": "Plxnc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVSRRKTPPRPPYPAAPLPLIAYLLALAAPARGADEPVWRSEQAIGAIAASRADGVFVASGSCLDQLDYSLKNRLSRLYRDQAGNCTEPVSLAPPARPRPGSSFSKLLLPYREGATGLEGLLLTGWTFDRGACEVRPLGNLNRSSLRNGTEVVSCHPQGSTAGVVYRASGTDLWYLAVAATYVLPEPETANRCNPAASDRDTAIALKNTEGRSLATQELGRLKLRGSAGSLHFVDAFLWNGSVYFPYYPYNYTSGAATGWPSMARIAQSTEVLFQGQAALDCDHGHPEGRRLLLSSSLVEAVDIWAGVFSAATGEGQERRSPATTALCLFRMSEIQAHARSCSWDFQATEHNCKEGDRPERVQPIASSTLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVVLGENLTSNCPEVIYEIKEETPVFYKLVPHPMKNIYIYLTAGKEVRRIPVANCSKRKSCSECLAAADPHCGWCLPLQRCTFQGDCTHAGSFENWLDISSGPKKCPKIQILRSLRERTTVTIVGSISARHSECVVKNADTGKLLCQGRSQLNWTCACNIPSRPSYNVLVVNATFSFPSWNLSERFNFTNCASLKECPACIRSGCAWCKRDKKCIHPFTPCEPSDYERNQELCQVAVEKSPKDSGGGRVKESKRNRTDGAVQVFYIKAIEPQKISTLGKSNVIVTGANFTQASNITMILRGTSTCERDVIRVSHVLNDTHMKFSLPSSRKEMKDVCIQFDGGTCSSAGALSYIALPHCSLIVPATTWISGGQNITIMGRNFDVIDNLIISHELKGNANVNINVSEYCAATFCRFLAPNLKSSKVRTNVAVKLRVQDTYLDCGTLQYLEDPRFTGYRVESEIDTELEVKIQKENDNFNISKDDIDITLFHGENKQFNCSFENITRNQDLTTILCKIKSIKNANTIASSSKKVRVKLGNLELYVEQESVPSTWYFLIALPILLAIVIVVAVVVTRYKSKELSRKQSQQLELLESELRKEIRDGFAELQMDKLDVVDSFGTVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFNTVALNVVFEKIPENESADVCRNISVNVLDCDTIGQAKEKVFQAFLSKNGSPYGLQLNEIGLELQVGTRQKELLDIDSSSVILEDGITKLNTIGHYEISNGSTIKVFKKIANFTSDVEYSDDHCHLILPDSEAFQVVQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDSCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLPPLSSLEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQKQLLHVKVLFDEKKKCKWM", "length": 1574 }, "evidence": [ { "id": "A0A3Q1LTZ7", "url": "https://omabrowser.org/oma/group/A0A3Q1LTZ7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTZ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTZ7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTZ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTZ7" } ], "pmid": "" }, { "name": "cerebellar climbing fiber to Purkinje cell synapse", "id": "GO:0150053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150053", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTZ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTZ7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "semaphorin receptor activity", "id": "GO:0017154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017154", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTZ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTZ7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of synapse pruning", "id": "GO:1905806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905806", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTZ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTZ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1057, "end_pos": 1059, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1069, "end_pos": 1071, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1085, "end_pos": 1087, "annotation": "n_glycosylation_sequon" }, { "start_pos": 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"annotation": "n_glycosylation_sequon" }, { "start_pos": 878, "end_pos": 880, "annotation": "n_glycosylation_sequon" }, { "start_pos": 893, "end_pos": 895, "annotation": "n_glycosylation_sequon" }, { "start_pos": 897, "end_pos": 899, "annotation": "n_glycosylation_sequon" }, { "start_pos": 902, "end_pos": 904, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LTZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTZ7" }, { "id": "PS51004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sema", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 455, "start_aa": "Met", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], 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"o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LR80-1", "uniprot_ac": "A0A3Q1LR80", "uniprot_id": "A0A3Q1LR80_BOVIN", "mass": { "chemical_mass": 83889.0, "monoisotopic_mass": 83889.0 }, "refseq": {}, "gene_names": [ { "name": "LARP4B", "type": "recommended", "evidence": [ { "id": "A0A3Q1LR80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR80" } ] } ], "protein_names": [ { "name": "La ribonucleoprotein 4B", "type": "synonym", "evidence": [ { "id": "A0A3Q1LR80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR80/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR80" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LARP4B", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR80", "locus": { "chromosome": "13", "start_pos": 46478576, "end_pos": 46390032, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013899", "url": "https://www.ensembl.org/id/ENSBTAG00000013899" } ] } } ], "crossref": [ { "id": "A0A3Q1LR80", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LR80", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013899", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013899", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08036", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08036", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12706", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12706", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RMQNTTT", "url": "https://omabrowser.org/oma/group/RMQNTTT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LR80", "url": "https://www.orthodb.org/?gene=A0A3Q1LR80", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22792", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22792", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22792:SF43", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22792:SF43", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05383", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05383", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26088", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26088", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LR80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LR80-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTG5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTG5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MV85", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MV85-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV85-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHX7", "url": "https://www.uniprot.org/uniprotkb/F1MHX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHX7-1", "url": "https://www.uniprot.org/uniprotkb/F1MHX7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLPELFSKACGLEGSNTDSLANIELLPVEPQSKQLMTSDQDTKVVAEPQGQRVQEGKDSTHLMNGPISQTTSQSSSIPALSQVPTAKVSELNPNAKVWGTPLLQLEARGAADGGVSTVWEAPPGRGHLGLDTNGDGDKSHDNVGLSDLQESDQTAMSTLGLDHSEYESPPESGETGGNDSQPESQEDPREVLKKTLEFCLSRENLASDMYLISQMDSDQYVPITTVANLDHIKKLSTDMDLIVEVLRSLPLVQVDEKGEKVRPNQNRCIVILREIPESTPVEEVEALFKGDNLPRFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQGKPIKARIKAKAIAINTFLPKNGFRPLDMSLYTQQRYTASFYLPPVYSPQQQFPLYSLIAPQTWSATHSYLDPPLVTPFPNTGFINGFTSPTFKPAASPLASLRQYPPRSRNPSKSHLRHAIPSAERGPGLLESPSIFNFTADRLMNGVRSPQVRQTAQPRARLQNPPAFAKRDVGPGRVEQSSFESSPGLGRGRKSSFGYRKKREEKFTRSQTQSPTPPRPPSPSFELGLSSFPPLPGAAGHLKTEDLFENRLSGLLTGTSKERSLNADASTNTLPAVHPREPLAPCAVSAACERTPSPARPPEDAKVVEKQRETPSVDRPPPALALSTTASKSVQVNGAASELRKPSYAEICQRTSREPPSSPLQPPKEQKPNPVGSGKEERKVTEREPPAPKSSPGPPKDQRRPLGRRPSPPGLGRRPHREQSPPPRPPQ", "length": 765, "header": "tr|A0A3Q1LR80-1|A0A3Q1LR80_BOVIN Isoform 1 of La ribonucleoprotein 4B OS=Bos taurus OX=9913 GN=LARP4B PE=4 SV=2 CANONICAL=A0A3Q1LR80-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LR80-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR80/entry", "sequence": { "sequence": "MLPELFSKACGLEGSNTDSLANIELLPVEPQSKQLMTSDQDTKVVAEPQGQRVQEGKDSTHLMNGPISQTTSQSSSIPALSQVPTAKVSELNPNAKVWGTPLLQLEARGAADGGVSTVWEAPPGRGHLGLDTNGDGDKSHDNVGLSDLQESDQTAMSTLGLDHSEYESPPESGETGGNDSQPESQEDPREVLKKTLEFCLSRENLASDMYLISQMDSDQYVPITTVANLDHIKKLSTDMDLIVEVLRSLPLVQVDEKGEKVRPNQNRCIVILREIPESTPVEEVEALFKGDNLPRFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQGKPIKARIKAKAIAINTFLPKNGFRPLDMSLYTQQRYTASFYLPPVYSPQQQFPLYSLIAPQTWSATHSYLDPPLVTPFPNTGFINGFTSPTFKPAASPLASLRQYPPRSRNPSKSHLRHAIPSAERGPGLLESPSIFNFTADRLMNGVRSPQVRQTAQPRARLQNPPAFAKRDVGPGRVEQSSFESSPGLGRGRKSSFGYRKKREEKFTRSQTQSPTPPRPPSPSFELGLSSFPPLPGAAGHLKTEDLFENRLSGLLTGTSKERSLNADASTNTLPAVHPREPLAPCAVSAACERTPSPARPPEDAKVVEKQRETPSVDRPPPALALSTTASKSVQVNGAASELRKPSYAEICQRTSREPPSSPLQPPKEQKPNPVGSGKEERKVTEREPPAPKSSPGPPKDQRRPLGRRPSPPGLGRRPHREQSPPPRPPQ", "length": 765, "header": "tr|A0A3Q1LR80-1|A0A3Q1LR80_BOVIN Isoform 1 of La ribonucleoprotein 4B OS=Bos taurus OX=9913 GN=LARP4B PE=4 SV=2 CANONICAL=A0A3Q1LR80-1" }, "locus": { "chromosome": "13", "start_pos": 46477572, "end_pos": 46395087, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086707.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086707.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062759.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062759.2" } ] } }, { "isoform_ac": "A0A3Q1LTG5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTG5/entry", "sequence": { "sequence": "MTSDQDTKVVAEPQGQRVQEGKDSTHLMNGPISQTTSQSSSIPALSQVPTAKVSELNPNAKVWGTPLLQLEARGAADGGVSTVWEAPPGRGHLGLDTNGDGDKSHDNVGLSDLQESDQTAMSTLGLDHSEYESPPESGETGGNDSQPESQEDPREVLKKTLEFCLSRENLASDMYLISQMDSDQYVPITTVANLDHIKKLSTDMDLIVEVLRSLPLVQVDEKGEKVRPNQNRCIVILREIPESTPVEEVEALFKGDNLPRFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQGKPIKARIKAKAIAINTFLPKNGFRPLDMSLYTQQRYTASFYLPPVYSPQQQFPLYSLIAPQTWSATHSYLDPPLVTPFPNTGFINGFTSPTFKPAASPLASLRQYPPRSRQVCERGRLQSLQGCNRRSLPHCALPKASRNPSKSHLRHAIPSAERGPGLLESPSIFNFTADRLMNGVRSPQVRQTAQPRARLQNPPAFAKRDVGPGRVEQSSFESSPGLGRGRKSSFGYRKKREEKFTRSQTQSPTPPRPPSPSFELGLSSFPPLPGAAGHLKTEDLFENRLSGLLTGTSKERSLNADASTNTLPAVHPREPLAPCAVSAACERTPSPARPPEDAKVVEKQRETPSVDRPPPALALSTTASKSVQVNGAASELRKPSYAEICQRTSREPPSSPLQPPKEQKPNPVGSGKEERKVTEREPPAPKSSPGPPKDQRRPLGRRPSPPGLGRRPHREQSPPPRPPQ", "length": 759, "header": "tr|A0A3Q1LTG5-1|A0A3Q1LR80_BOVIN Computationally mapped isoform of La ribonucleoprotein 4B OS=Bos taurus OX=9913 GN=LARP4B PE=4 SV=2 CANONICAL=A0A3Q1LR80-1" }, "locus": { "chromosome": "13", "start_pos": 46477572, "end_pos": 46422154, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085941.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085941.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063755.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063755.2" } ] } }, { "isoform_ac": "A0A3Q1MV85-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV85/entry", "sequence": { "sequence": "MAESAEELKSLLMKDSLANIELLPVEPQSKQLMTSDQDTKVVAEPQGQRVQEGKDSTHLMNGPISQTTSQSSSIPALSQVPTAKVSELNPNAKVWGTPLLQLEARGAADGGVSTVWEAPPGRGHLGLDTNGDGDKSHDNVGLSDLQESDQTAMSTLGLDHSEYESPPESGETGGNDSQPESQEDPREVLKKTLEFCLSRENLASDMYLISQMDSDQYVPITTVANLDHIKKLSTDMDLIVEVLRSLPLVQVDEKGEKVRPNQNRCIVILREIPESTPVEEVEALFKGDNLPRFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQGKPIKARIKAKAIAINTFLPKNGFRPLDMSLYTQQRYTASFYLPPVYSPQQQFPLYSLIAPQTWSATHSYLDPPLVTPFPNTGFINGFTSPTFKPAASPLASLRQYPPRSRNPSKSHLRHAIPSAERGPGLLESPSIFNFTADRLMNGVRSPQVRQTAQPRARLQNPPAFAKRDVGPGRVEQSSFESSPGLGRGRKSSFGYRKKREEKFTRSQTQSPTPPRPPSPSFELGLSSFPPLPGAAGHLKTEDLFENRLSGLLTGTSKERSLNADASTNTLPAVHPREPLAPCAVSAACERTPSPARPPEDAKVVEKQRETPSVDRPPPALALSTTASKSVQVNGAASELRKPSYAEICQRTSREPPSSPLQPPKEQKPNPVGSGKEERKVTEREPPAPKSSPGPPKDQRRPLGRRPSPPGLGRRPHREQSPPPRPPQ", "length": 762, "header": "tr|A0A3Q1MV85-1|A0A3Q1LR80_BOVIN Computationally mapped isoform of La ribonucleoprotein 4B OS=Bos taurus OX=9913 GN=LARP4B PE=4 SV=2 CANONICAL=A0A3Q1LR80-1" }, "locus": { "chromosome": "13", "start_pos": 46477572, "end_pos": 46405808, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087211.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087211.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058859.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058859.2" } ] } }, { "isoform_ac": "F1MHX7-1", "url": "https://www.uniprot.org/uniprotkb/F1MHX7/entry", "sequence": { "sequence": "MTSDQDTKVVAEPQGQRVQEGKDSTHLVPTAKVSELNPNAKVWGTPLLQLEARGAADGGVSTVWEAPPGRGHLGLDTNGDGDKSHDNVGLSDLQESDQTAMSTLGLDHSEYESPPESGETGGNDSQPESQEDPREVLKKTLEFCLSRENLASDMYLISQMDSDQYVPITTVANLDHIKKLSTDMDLIVEVLRSLPLVQVDEKGEKVRPNQNRCIVILREIPESTPVEEVEALFKGDNLPRFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQGKPIKARIKAKAIAINTFLPKNGFRPLDMSLYTQQRYTASFYLPPVYSPQQQFPLYSLIAPQTWSATHSYLDPPLVTPFPNTGFINGFTSPTFKPAASPLASLRQYPPRSRNPSKSHLRHAIPSAERGPGLLESPSIFNFTADRLMNGVRSPQVRQTAQPRARLQNPPAFAKRDVGPGRVEQSSFESSPGLGRGRKSSFGYRKKREEKFTRSQTQSPTPPRPPSPSFELGLSSFPPLPGAAGHLKTEDLFENRLSGLLTGTSKERSLNADASTNTLPAVHPREPLAPCAVSAACERTPSPARPPEDAKVVEKQRETPSVDRPPPALALSTTASKSVQVNGAASELRKPSYAEICQRTSREPPSSPLQPPKEQKPNPVGSGKEERKVTEREPPAPKSSPGPPKDQRRPLGRRPSPPGLGRRPHREQSPPPRPPQ", "length": 710, "header": "tr|F1MHX7-1|A0A3Q1LR80_BOVIN Computationally mapped isoform of La ribonucleoprotein 4B OS=Bos taurus OX=9913 GN=LARP4B PE=4 SV=5 CANONICAL=A0A3Q1LR80-1" }, "locus": { "chromosome": "13", "start_pos": 46477572, "end_pos": 46422154, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018457.8", "url": "https://www.ensembl.org/id/ENSBTAT00000018457.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018457.8", "url": "https://www.ensembl.org/id/ENSBTAP00000018457.8" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 550, "start_aa": "Thr", "end_pos": 550, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr550", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287AM13-1", "protein_name": "La ribonucleoprotein 4B", "gene_name": "LARP4B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTSDQDAKVVAEPQGQRVQEGKDCAHLMNGPISQATSQTSSIPALSQVPTAKVSELNPNAKVWGTHMLHLEAGSTADGGVRAAWEETPRRGQEGLDTHGSGDRSPENAALSDLQESDRTAMSTLGLDHSEYESPPENSETGGNESQPEGQEDPREVLKKTLEFCLSRENLASDMYLISQMDSDQYVPITTVANLDHIKKLSTDMDLIVEVLRSLPLVQVDEKGEKVRPNQNRCIVILREISESTPVEEVEALFKGDNLPKFINCEFAYNDNWFITFETEADAQQAYRYLREEVKTFQGKPIKARIKAKAIAINTFLPKNGFRPLDMSLYAQQRYTASFYFPPVYSPQQPFPLYSLIAPQTWSATHSYLDPPLVTPFPNTGFINGFTSPTFKPAASPLASLRQYPPRSRNPSKSHLRQAIPSAERGPGLLESPSIFNFTAERLINGVRSPQTRQASQPRARIQTPAAFAKREVGPGRVEQSSLESPPGLGRGRKNSFGYRKKREEKFTRSQTQSPTPPRPPSPSFELGLSSFPPLPGAAGHLKTEDSFENRLPGLLAGPAKERSLNADASTNTQPAAPSREPPATCALTAACERAPSPARPPEDPEVVERQRETPSVDRPPPALSTTASKSVQVNGGATELRKPSYAEICQRTSREPPSSVLQPQKEQKPHAVACGKDERKLAEREPPAPRSSPGPAKDQRRPLGRRPSPPAPGRRPHRDQSPPPRSPQ", "length": 728 }, "evidence": [ { "id": "A0A3Q1LR80", "url": "https://omabrowser.org/oma/group/A0A3Q1LR80/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7FI18-1", "protein_name": "La-related protein 4B isoform X1", "gene_name": "Larp4b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTSDQDTKIVAEPQAQRVQEGKDSSHLMNGPISQTTSQTSSIPALTQTPYQLPVSEDGVVWGWQTRGGLFVPTTKVSELNPNAKVWGLHLEASSAAVGVNASWEEAPDHPVDCDQQVIGLDANGDGDKSHENAGLSDLQEADQTDMSTLALDHSEYEPLPESNDTGGNESQPESQEDPREVLKKTLEFCLSRENLASDMYLISQMDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVRPNQNRCIVILREISESTPVEEVEALFKGDNLPKFINCEFAYNDNWFITFETEADAQQAYKYLREEVRTFQGKPIKARIKAKAIAINTFLPKNGFRPLDMNLYTQQRYATSFYLPPVYSPQQQFPLYGLITPQTWSTTHSYLDPPLVTPFPSTGFINGFTSPTFKPAASPLTSLRQYPPRSRNPSKSHLRHAIPSTERGPGLLESPSIFNFTADRLINGVRSPQTRQAGQTRTRIQNPSAYAKREIGTGRVEPSSLESSPGLGRGRKNSFGYRKKREEKFTSSQTQSPTPPKPPSPSFELGLSNFPPLPGAAGNLKAEDLFENRLSGLIIGSSKERNLSTDASTNTVPVVVPREPSVPAPCAVSTAFERSPSPAHLPEDPKVAEKQRETHSVDRLPSTPTTTACKSVQVNGAATELRKPSYAEICQRTSRETPSSPLQPPKEQKPNTVACGKEEKKLAEPVERYREPPALKSTPGAPKDQRRQPGRRPSPPAAGKRLNREQNTPPKSPQ", "length": 760 }, "evidence": [ { "id": "A0A3Q1LR80", "url": "https://omabrowser.org/oma/group/A0A3Q1LR80/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q6A0A2-1", 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"OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92615-1", "protein_name": "La-related protein 4B", "gene_name": "LARP4B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSDQDAKVVAEPQTQRVQEGKDSAHLMNGPISQTTSQTSSIPPLSQVPATKVSELNPNAEVWGAPVLHLEASSAADGVSAAWEEVAGHHADRGPQGSDANGDGDQGHENAALPDPQESDPADMNALALGPSEYDSLPENSETGGNESQPDSQEDPREVLKKTLEFCLSRENLASDMYLISQMDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVRPNQNRCIVILREISESTPVEEVEALFKGDNLPKFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQGKPIKARIKAKAIAINTFLPKNGFRPLDVSLYAQQRYATSFYFPPMYSPQQQFPLYSLITPQTWSATHSYLDPPLVTPFPNTGFINGFTSPAFKPAASPLTSLRQYPPRSRNPSKSHLRHAIPSAERGPGLLESPSIFNFTADRLINGVRSPQTRQAGQTRTRIQNPSAYAKREAGPGRVEPGSLESSPGLGRGRKNSFGYRKKREEKFTSSQTQSPTPPKPPSPSFELGLSSFPPLPGAAGNLKTEDLFENRLSSLIIGPSKERTLSADASVNTLPVVVSREPSVPASCAVSATYERSPSPAHLPDDPKVAEKQRETHSVDRLPSALTATACKSVQVNGAATELRKPSYAEICQRTSKEPPSSPLQPQKEQKPNTVGCGKEEKKLAEPAERYREPPALKSTPGAPRDQRRPAGGRPSPSAMGKRLSREQSTPPKSPQ", "length": 738 }, "evidence": [ { "id": "A0A3Q1LR80", "url": "https://omabrowser.org/oma/group/A0A3Q1LR80/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR80" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR80" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of translation", "id": "GO:0045727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045727", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR80" } ], "pmid": "" }, { "name": "positive regulation of 3'-UTR-mediated mRNA stabilization", "id": "GO:1905870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905870", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR80" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR80" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR80" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 178, "end_pos": 180, "annotation": 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"count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LR82-1", "uniprot_ac": "A0A3Q1LR82", "uniprot_id": "A0A3Q1LR82_BOVIN", "mass": { "chemical_mass": 37080.0, "monoisotopic_mass": 37080.0 }, "refseq": {}, "gene_names": [ { 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"IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SIIMSHT", "url": "https://omabrowser.org/oma/group/SIIMSHT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LR82", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LR82-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR82-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGILQARILERIARPTVLGPPRRMVAENHSTVTEFILGGLTSQPELQLPLFFLFLGIYSITMVGNLGMITLICLNAQLHTPMYYFLSNLSFVDLCYSSVTTPKMLVNFVSGKNTISYAGCMAQLYFFIVFVVAECYMLTVMAYDRYVAICRPLLYNIIMSHRVCSLLVAGVYIMGLIGSTIETGLMLKLPYCEHLISHYFCDILPLMKLSCFSTYDIEMTVFFLAGFNIVVTSLTVLISYAFILSSILRISTTEGRSKAFNTCSSHFAAVGIFYGTTAFMYLKPSTASSLAQENVASVFYTTVIPMLNPLIYSLRNKEVKAAMHKTLRGKLL", "length": 332, "header": "tr|A0A3Q1LR82-1|A0A3Q1LR82_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8A1C PE=3 SV=1 CANONICAL=A0A3Q1LR82-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LR82-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR82/entry", "sequence": { "sequence": "MGILQARILERIARPTVLGPPRRMVAENHSTVTEFILGGLTSQPELQLPLFFLFLGIYSITMVGNLGMITLICLNAQLHTPMYYFLSNLSFVDLCYSSVTTPKMLVNFVSGKNTISYAGCMAQLYFFIVFVVAECYMLTVMAYDRYVAICRPLLYNIIMSHRVCSLLVAGVYIMGLIGSTIETGLMLKLPYCEHLISHYFCDILPLMKLSCFSTYDIEMTVFFLAGFNIVVTSLTVLISYAFILSSILRISTTEGRSKAFNTCSSHFAAVGIFYGTTAFMYLKPSTASSLAQENVASVFYTTVIPMLNPLIYSLRNKEVKAAMHKTLRGKLL", "length": 332, "header": "tr|A0A3Q1LR82-1|A0A3Q1LR82_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8A1C PE=3 SV=1 CANONICAL=A0A3Q1LR82-1" }, "locus": { "chromosome": "29", "start_pos": 28054476, "end_pos": 28053257, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070897.1", "url": "https://www.ensembl.org/id/ENSBTAT00000070897.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057541.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057541.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D3ZMV7-1", "protein_name": "Olfactory receptor", "gene_name": "Or8a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVENHSTVTEFILGGLTHRPELQLPLFLLFLGIYTVTMVGNLGMITLIGLNTQLHTPMYFFLSNLSLVDLCYSSVITPKMLINFVSQRNLISYVGCMSQLYFFLVFVIAECYMLTVMAYDRYVAICHPLLYNIIMSPALCSLLVAFVYAVGLIGSAIETGLMLKLNYCEDFISHYFCDILPLMKLSCSSTYDVEMAVFFLAGFDIIVTSLTVLISYAFILSSILHISSTEGRSKAFSTCSSHFAAVGLFYGSTAFMYLKPSTASSLAQENVASVFYTTVIPMLNPLIYSLRNKEVKAALDKTLRRKLF", "length": 309 }, "evidence": [ { "id": "A0A3Q1LR82", "url": "https://omabrowser.org/oma/group/A0A3Q1LR82/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR82", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR82" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR82", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR82" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR82", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR82" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR82", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR82" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LR82", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR82" } ], "pmid": "" }, { "name": "sensory 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"XP_005225528", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225528", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRB9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIL3", "url": "https://www.uniprot.org/uniprotkb/E1BIL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIL3-1", "url": "https://www.uniprot.org/uniprotkb/E1BIL3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIGCGACEPEVKMAGGQAAAALPSWKMAARRSLSARGRGVLQAAAGRLLPLLLLSCCCGAGGCTAVGENEETVIIGLRLEDTNDVSFMEGGALRVSERTRVKLRVYGQNINNETWSRIAFTEHERQRHSPGERGLGGPAPPEPDSGPQRCGIRTSDIIILPHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAGGSGSAGSAVGGKGGSGVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKFLLPFWLQVIFISLLLCLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYPVSKLLDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITGEAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDCTPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTDNRTKKKVAHRERKQDFSAFKQTDSEMKVKISPQLLLAMHRFLATEVEAFSPSQMSEKILLRLLKHPNVIQELKYDEKNKKAPEYYLYQRNKPVDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTASPVPLSLSRTFVVSRTELLAAGSPGENKSPPRPCGLNHSDSLSRSDRIDAVTPTLGNSNNQLNSAFLQVYIPDYSVRALSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTELHDGLPDETANLLNEQNCVTHTKANHSLHSEGAI", "length": 875, "header": "tr|A0A3Q1LRB9-1|A0A3Q1LRB9_BOVIN Isoform 1 of Metal transporter OS=Bos taurus OX=9913 GN=CNNM2 PE=3 SV=1 CANONICAL=A0A3Q1LRB9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRB9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB9/entry", "sequence": { "sequence": "MIGCGACEPEVKMAGGQAAAALPSWKMAARRSLSARGRGVLQAAAGRLLPLLLLSCCCGAGGCTAVGENEETVIIGLRLEDTNDVSFMEGGALRVSERTRVKLRVYGQNINNETWSRIAFTEHERQRHSPGERGLGGPAPPEPDSGPQRCGIRTSDIIILPHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAGGSGSAGSAVGGKGGSGVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKFLLPFWLQVIFISLLLCLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYPVSKLLDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITGEAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDCTPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTDNRTKKKVAHRERKQDFSAFKQTDSEMKVKISPQLLLAMHRFLATEVEAFSPSQMSEKILLRLLKHPNVIQELKYDEKNKKAPEYYLYQRNKPVDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTASPVPLSLSRTFVVSRTELLAAGSPGENKSPPRPCGLNHSDSLSRSDRIDAVTPTLGNSNNQLNSAFLQVYIPDYSVRALSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTELHDGLPDETANLLNEQNCVTHTKANHSLHSEGAI", "length": 875, "header": "tr|A0A3Q1LRB9-1|A0A3Q1LRB9_BOVIN Isoform 1 of Metal transporter OS=Bos taurus OX=9913 GN=CNNM2 PE=3 SV=1 CANONICAL=A0A3Q1LRB9-1" }, "locus": { "chromosome": "26", "start_pos": 23728127, "end_pos": 23551416, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070051.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070051.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059542.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059542.1" } ] } }, { "isoform_ac": "E1BIL3-1", "url": "https://www.uniprot.org/uniprotkb/E1BIL3/entry", "sequence": { "sequence": "MIGCGACEPEVKMAGGQAAAALPSWKMAARRSLSARGRGVLQAAAGRLLPLLLLSCCCGAGGCTAVGENEETVIIGLRLEDTNDVSFMEGGALRVSERTRVKLRVYGQNINNETWSRIAFTEHERQRHSPGERGLGGPAPPEPDSGPQRCGIRTSDIIILPHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAGGSGSAGSAVGGKGGSGVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKFLLPFWLQVIFISLLLCLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYPVSKLLDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITGEAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDCTPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTDNRTKKKVAHRERKQDFSAFKQTDSEMKVKISPQLLLAMHRFLATEVEAFSPSQMSEKILLRLLKHPNVIQELKYDEKNKKAPEYYLYQRNKPVDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTASPGENKSPPRPCGLNHSDSLSRSDRIDAVTPTLGNSNNQLNSAFLQVYIPDYSVRALSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTELHDGLPDETANLLNEQNCVTHTKANHSLHSEGAI", "length": 853, "header": "tr|E1BIL3-1|E1BIL3_BOVIN Computationally mapped isoform of Metal transporter OS=Bos taurus OX=9913 GN=CNNM2 PE=3 SV=2 CANONICAL=A0A3Q1LRB9-1" }, "locus": { "chromosome": "26", "start_pos": 23728127, "end_pos": 23551416, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017085.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017085.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017085.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017085.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504632", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504632", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AM25-1", "protein_name": "Metal transporter", "gene_name": "CNNM2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIGCGACEPEVKMAGGPAAAALPTRKMAARRSLSARGQGVLQAAAGRLLPLLLLSCCCSAGGCAAAGENEETVIIGLRLEDTNDVSFMEGGALRVSERTRVKLRVYGQNINNETWSRIAFTEHERRRHSPGERGLGGPAPPEPDSGPQRCGIRTSDIIILPHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAGGSGSAGGAVGGKGGSGVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKFLLPFWLQVIFISLLLCLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYPVSKLLDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITGEAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDCTPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTDNRTKKKVAHRERKQDFSAFKQTDSEMKVKISPQLLLAMHRFLATEVEAFSPSQMSEKILLRLLKHPNVIQELKYDEKNKKAPEYYLYQRNKPVDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTASPVPLSLSRTFVVSRTELLAAGSPGENKSPPRPCGLNHSDSLSRSDRIDAMTPTLGSSNNQLNSSFLQVYIPDYSVRALSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTELHDGLPDETANLLNEQNCVTHSKANHSLHSEGAI", "length": 875 }, "evidence": [ { "id": "A0A3Q1LRB9", "url": "https://omabrowser.org/oma/group/A0A3Q1LRB9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3TWN3-1", "protein_name": "Metal transporter CNNM2", "gene_name": "Cnnm2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIGCGACEPEVKMAGGQAAAALPTWKMAARRSLSARGRGVLQAAAGRLLPLLLLSCCWGAGGCTAAGENEETVIIGLRLEDTNDVSFMEGGALRVSERTRVKLRVYGQNINNETWSRIAFTEHERRRHTPSERGLGGPAPPEPDSGPQRCGIRTSDIIILPHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAGGSGSASGTVGGKGGAGVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKFLLPFWLQVIFISLLLCLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYPVSKLLDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITGEAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDCTPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTDNRTKKKVAHRERKQDFSAFKQTDSEMKVKISPQLLLAMHRFLATEVEAFSPSQMSEKILLRLLKHPNVIQELKYDEKNKKAPECYLYQRNKPVDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTASPVPLSLSRTFVVSRTEVLAAGSPGENKSPPRPCGLNHSDSLSRSDRIDAMTPTLGSSNNQLSSSFLQVYIPDYSVRALSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTELHDGLPDETANLLNEQNCVSHNKANHSLHSEGAI", "length": 875 }, "evidence": [ { "id": "A0A3Q1LRB9", "url": "https://omabrowser.org/oma/group/A0A3Q1LRB9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5U2P1-1", "protein_name": "Metal transporter CNNM2", "gene_name": "Cnnm2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIGCGACEPEVKMAGGQAAAALPTWKMAARRSLSARGRGVLQAAAGRLLPLLLLSCCCSAGGCTAAGENEETVIIGLRLEDTNDVSFMEGGALRVSERTRVKLRVYGQNINNETWSRIAFTEHERRRHTPGERGLGGPAPPEPDSGPQRCGIRTSDIIILPHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAGGSGSASGTVGGKGGAGVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKFLLPFWLQVIFISLLLCLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYPVSKLLDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITGEAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDCTPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTDNRTKKKVAHRERKQDFSAFKQTDSETKVKISPQLLLAMHRFLATEVEAFSPSQMSEKILLRLLKHPNVIQELKYDEKNKKAPECYLYQRNKPVDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTASPVPLSLSRTFVVSRTEVLAAGSPGENKSPPRPCGLNHSDSLSRSDRIDAMTPTLGSSNNQLSSSFLQVYIPDYSVRALSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTEMHDGLPDETANLLNEQNCVSHNKANHSLHSEGAI", "length": 875 }, "evidence": [ { "id": "A0A3Q1LRB9", "url": "https://omabrowser.org/oma/group/A0A3Q1LRB9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9H8M5-1", "protein_name": "Metal transporter CNNM2", "gene_name": "CNNM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIGCGACEPKVKMAGGQAAAALPTWKMAARRSLSARGRGILQAAAGRLLPLLLLSCCCGAGGCAAVGENEETVIIGLRLEDTNDVSFMEGGALRVSERTRVKLRVYGQNINNETWSRIAFTEHERRRHSPGERGLGGPAPPEPDSGPQRCGIRTSDIIILPHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAGGSGSTGGAVGGKGGSGVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKFLLPFWLQVIFISLLLCLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYPVSKLLDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITGEAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDCTPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTDNRTKKKVAHRERKQDFSAFKQTDSEMKVKISPQLLLAMHRFLATEVEAFSPSQMSEKILLRLLKHPNVIQELKYDEKNKKAPEYYLYQRNKPVDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTASPVPLSLSRTFVVSRTELLAAGSPGENKSPPRPCGLNHSDSLSRSDRIDAVTPTLGSSNNQLNSSLLQVYIPDYSVRALSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTELHDGLPDETANLLNEQNCVTHSKANHSLHNEGAI", "length": 875 }, "evidence": [ { "id": "A0A3Q1LRB9", "url": "https://omabrowser.org/oma/group/A0A3Q1LRB9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB9" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB9" } ], "pmid": "" }, { "name": "magnesium ion transmembrane transporter activity", "id": "GO:0015095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015095", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB9" } ], "pmid": "" }, { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "magnesium ion homeostasis", "id": "GO:0010960", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010960", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB9" } ], "pmid": "" }, { "name": "monoatomic ion transport", "id": "GO:0006811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006811", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 527, "end_pos": 529, "annotation": "n_glycosylation_sequon" }, { "start_pos": 591, "end_pos": 593, "annotation": "n_glycosylation_sequon" }, { "start_pos": 747, "end_pos": 749, "annotation": "n_glycosylation_sequon" }, { "start_pos": 757, "end_pos": 759, "annotation": "n_glycosylation_sequon" }, { "start_pos": 866, "end_pos": 868, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LRB9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 875, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LRB9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LRB9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LRB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB9" }, { "id": "PS51371", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51371" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CBS", "eco_id": "ECO_0000259", "start_pos": 518, "end_pos": 584, "start_aa": "Tyr", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LRB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRB9" }, { "id": "PS51846", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51846" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CNNM transmembrane", "eco_id": "ECO_0000259", "start_pos": 251, "end_pos": 431, "start_aa": "Phe", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 }, { "start_pos": 327, "end_pos": 329 }, { "start_pos": 527, "end_pos": 529 }, { "start_pos": 591, "end_pos": 593 }, { "start_pos": 747, "end_pos": 749 }, { "start_pos": 757, "end_pos": 759 }, { "start_pos": 866, "end_pos": 868 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", 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"categories": [ "Protein" ] }, { "id": "F1MS72-1", "url": "https://www.uniprot.org/uniprotkb/F1MS72-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWSGGSGKARGWEAAAGGRSGPGRLSRRRIMSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQTAPPAAAMQQHAVGHHGAVTAAYHMTAAAVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGAGCQQQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGATSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLPHLNSSGSDYGTMSCSTLLYGRTW", "length": 400, "header": "tr|A0A3Q1LRH0-1|A0A3Q1LRH0_BOVIN Isoform 1 of Thyroid nuclear factor 1 OS=Bos taurus OX=9913 GN=NKX2-1 PE=3 SV=1 CANONICAL=A0A3Q1LRH0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRH0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRH0/entry", "sequence": { "sequence": 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"https://www.ensembl.org/id/ENSBTAP00000068847.1" } ] } }, { "isoform_ac": "F1MS72-1", "url": "https://www.uniprot.org/uniprotkb/F1MS72/entry", "sequence": { "sequence": "MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQTAPPAAAMQQHAVGHHGAVTAAYHMTAAAVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGAGCQQQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGATSLQGHAQQQAQQQAQAAQAAAAAISVGSGGPGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLPHLNSSGSDYGTMSCSTLLYGRTW", "length": 370, "header": "tr|F1MS72-1|F1MS72_BOVIN Computationally mapped isoform of Thyroid nuclear factor 1 OS=Bos taurus OX=9913 GN=NKX2-1 PE=3 SV=2 CANONICAL=A0A3Q1LRH0-1" }, "locus": { "chromosome": "21", "start_pos": 46704644, "end_pos": 46702603, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000704.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000704.6" }, { "database": "Ensembl Peptide", "id": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ24", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ24-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDGDSESERETRRVTAVAVMAAEPGHMDMGAEALPGPDEAAAAAAFAEVTTVTVANVGASADNVFTTSVANAASLSGHVLSGRTALQIGDSLNPEKATLIVVHTDGSIVETAGLKAPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKESELPATPVKKDAPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEASVQPPCRVGHPEPHYPGYQDSCQITPFPEAALPTSHPKIVLTSLPALAAPPSTPTKAVSPAVVSGLEVSEQRTWLYLEEMVNSLLSTAQQLKTLFEQTKQASSYREAAAAQARAQADAERKEEYVGKAQGIGNTFCTQAAPAPQGSSQCRPLLQQSCVNCGREALSECTGCHKVNYCSTFCQRKDWKDHQHMCGQSAAVTVQGDDVHVGEGVIEKVTV", "length": 597, "header": "tr|A0A3Q1LRM9-1|A0A3Q1LRM9_BOVIN Isoform 1 of Deformed epidermal autoregulatory factor 1 homolog OS=Bos taurus OX=9913 GN=DEAF1 PE=4 SV=2 CANONICAL=A0A3Q1LRM9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRM9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9/entry", "sequence": { "sequence": "MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDGDSESERETRRVTAVAVMAAEPGHMDMGAEALPGPDEAAAAAAFAEVTTVTVANVGASADNVFTTSVANAASLSGHVLSGRTALQIGDSLNPEKATLIVVHTDGSIVETAGLKAPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKESELPATPVKKDAPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEASVQPPCRVGHPEPHYPGYQDSCQITPFPEAALPTSHPKIVLTSLPALAAPPSTPTKAVSPAVVSGLEVSEQRTWLYLEEMVNSLLSTAQQLKTLFEQTKQASSYREAAAAQARAQADAERKEEYVGKAQGIGNTFCTQAAPAPQGSSQCRPLLQQSCVNCGREALSECTGCHKVNYCSTFCQRKDWKDHQHMCGQSAAVTVQGDDVHVGEGVIEKVTV", "length": 597, "header": "tr|A0A3Q1LRM9-1|A0A3Q1LRM9_BOVIN Isoform 1 of Deformed epidermal autoregulatory factor 1 homolog OS=Bos taurus OX=9913 GN=DEAF1 PE=4 SV=2 CANONICAL=A0A3Q1LRM9-1" }, "locus": { "chromosome": "29", "start_pos": 50667304, "end_pos": 50639439, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079372.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079372.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057715.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057715.2" } ] } }, { "isoform_ac": "A0AAA9S5Y7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Y7/entry", "sequence": { "sequence": "MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDGDSESERETRRVTAVAVMAAEPGHMDMGAEALPGPDEAAAAAAFAEVTTVTVANVGASADNVFTTSVANAASLSGHVLSGRTALQIGDSLNPEKATLIVVHTDGSIVETAGLKAPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKESELPATPVKKDAPKNITLLPATAATTLQEASVQPPCRVGHPEPHYPGYQDSCQITPFPEAALPTSHPKIVLTSLPALAAPPSTPTKAVSPAVVSGLEVSEQRTWLYLEEMVNSLLSTAQQLKTLFEQTKQASSYREAAAAQARAQADAERKEQSCVNCGREALSECTGCHKVNYCSTFCQRKDWKDHQHMCGQSAAVTVQGDDVHVGEGVIEKVTV", "length": 522, "header": "tr|A0AAA9S5Y7-1|A0A3Q1LRM9_BOVIN Computationally mapped isoform of Deformed epidermal autoregulatory factor 1 homolog OS=Bos taurus OX=9913 GN=DEAF1 PE=4 SV=1 CANONICAL=A0A3Q1LRM9-1" }, "locus": { "chromosome": "29", "start_pos": 50667304, "end_pos": 50639439, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100412.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100412.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078722.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078722.1" } ] } }, { "isoform_ac": "A0AAA9SBN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBN7/entry", "sequence": { "sequence": "MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDGDSESERETRRVTAVAVMAAEPGHMDMGAEALPGPDEAAAAAAFAEVTTVTVANVGASADNVFTTSVANAASLSGHVLSGRTALQIGDSLNPEKATLIVVHTDGSIVETAGLKAPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKESELPATPVKKDAPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVLTSLPALAAPPSTPTKAVSPAVVSGLEVSEQRTWLYLEEMVNSLLSTAQQLKTLFEQTKQASSYREAAAAQARAQADAERKEQSCVNCGREALSECTGCHKVNYCSTFCQRKDWKDHQHMCGQSAAVTVQGDDVHVGEGVIEKVTV", "length": 522, "header": "tr|A0AAA9SBN7-1|A0A3Q1LRM9_BOVIN Computationally mapped isoform of Deformed epidermal autoregulatory factor 1 homolog OS=Bos taurus OX=9913 GN=DEAF1 PE=4 SV=1 CANONICAL=A0A3Q1LRM9-1" }, "locus": { "chromosome": "29", "start_pos": 50667304, "end_pos": 50639439, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132423.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132423.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080891.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080891.1" } ] } }, { "isoform_ac": "A0AAA9SP85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP85/entry", "sequence": { "sequence": "MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDGDSESERETRRVTAVAVMAAEPGHMDMGAEALPGPDEAAAAAAFAEVTTVTVANVGASADNVFTTSVANAASLSGHVLSGRTALQIGDSLNPEKATLIVVHTDGSIVETAGLKAPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQTLSRVVVSHALSRVAVSHALSCVAVSFEPQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKESELPATPVKKDAPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEASVQPPCRVGHPEPHYPGYQDSCQITPFPEAALPTSHPKIVLTSLPALAAPPSTPTKAVSPAVVSGLEVSEQRTWLYLEEMVNSLLSTAQQLKTLFEQTKQASSYREAAAAQARAQADAERKEQSCVNCGREALSECTGCHKVNYCSTFCQRKDWKDHQHMCGQSAAVTVQGDDVHVGEGVIEKVTV", "length": 595, "header": "tr|A0AAA9SP85-1|A0A3Q1LRM9_BOVIN Computationally mapped isoform of Deformed epidermal autoregulatory factor 1 homolog OS=Bos taurus OX=9913 GN=DEAF1 PE=4 SV=2 CANONICAL=A0A3Q1LRM9-1" }, "locus": { "chromosome": "29", "start_pos": 50667304, "end_pos": 50639439, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097453.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097453.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088128.2", "url": "https://www.ensembl.org/id/ENSBTAP00000088128.2" } ] } }, { "isoform_ac": "A0AAA9TEY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEY3/entry", "sequence": { "sequence": "MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDGDSESERETRRVTAVAVMAAEPGHMDMGAEALPGPDEAAAAAAFAEVTTVTVANVGASADNVFTTSVANAASLSGHVLSGRTALQIGDSLNPEKATLIVVHTDGSIVETAGLKAPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKESELPATPVKKDAPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATAVLCELWPRGPERVHRLPQGQLLLHLLPAQGLEGPPAHVWSVCSRHCPGGRRPRRRGRDREGHRVRARGASAARKDPGGQGTLRTRRNLLAKLRVDVGRPAPSAARSHCRTRGGRWPLRGCWWTRPGPDARGAFFNPLDHERPVFPTGVSCSVTRVYIYVSCQ", "length": 538, "header": "tr|A0AAA9TEY3-1|A0A3Q1LRM9_BOVIN Computationally mapped isoform of Deformed epidermal autoregulatory factor 1 homolog OS=Bos taurus OX=9913 GN=DEAF1 PE=4 SV=1 CANONICAL=A0A3Q1LRM9-1" }, "locus": { "chromosome": "29", "start_pos": 50667600, "end_pos": 50639439, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088492.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088492.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095551.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095551.1" } ] } }, { "isoform_ac": "A0AAA9TF11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF11/entry", "sequence": { "sequence": "MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDGDSESERETRRVTAVAVMAAEPGHMDMGAEALPGPDEAAAAAAFAEVTTVTVANVGASADNVFTTSVANAASLSGHVLSGRTALQIGDSLNPEKATLIVVHTDGSIVETAGLKAPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKESELPATPVKKDAPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEASVQPPCRVGHPEPHYPGYQDSCQITPFPEAALPTSHPKIVLTSLPALAAPPSTPTKAVSPAVVSGLEVSEQRTWLYLEEMVNSLLSTAQQLKTLFEQTKQASSYREAAAAQARAQADAERKEQSCVNCGREALSECTGCHKVNYCSTFCQRKGGSRQMRVWTCLQGHPGCLPLSAFLKQGGRGWAPLPRKAGCSARAGPRPRGGDHSRSRDSVCPP", "length": 595, "header": "tr|A0AAA9TF11-1|A0A3Q1LRM9_BOVIN Computationally mapped isoform of Deformed epidermal autoregulatory factor 1 homolog OS=Bos taurus OX=9913 GN=DEAF1 PE=4 SV=1 CANONICAL=A0A3Q1LRM9-1" }, "locus": { "chromosome": "29", "start_pos": 50667196, "end_pos": 50639439, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130049.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130049.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096704.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096704.1" } ] } }, { "isoform_ac": "A0AAA9TQ24-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ24/entry", "sequence": { "sequence": "MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDGDSESERETRRVTAVAVMAAEPGHMDMGAEALPGPDEAAAAAAFAEVTTVTVANVGASADNVFTTSVANAASLSGHVLSGRTALQIGDSLNPEKATLIVVHTDGSIVETAGLKAPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKESELPATPVKKDAPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATGICWEGPRDWKYFLHTSSACPPRFITMQAFASAVLCELWPRGPERVHRLPQGQLLLHLLPAQGLEGPPAHVWSVCSRHCPGGRRPRRRGRDREGHRVRARGASAARKDPGGQGTLRTRRNLLAKLRVDVGRPAPSAARSHCRTRGGRWPLRGCWWTRPGPDARGAFFNPLDHERPVFPTGVSCSVTRVYIYVSCQ", "length": 570, "header": "tr|A0AAA9TQ24-1|A0A3Q1LRM9_BOVIN Computationally mapped isoform of Deformed epidermal autoregulatory factor 1 homolog OS=Bos taurus OX=9913 GN=DEAF1 PE=4 SV=1 CANONICAL=A0A3Q1LRM9-1" }, "locus": { "chromosome": "29", "start_pos": 50667600, "end_pos": 50639439, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129148.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129148.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099128.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099128.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:509260", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509260", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O75398-1", "protein_name": "Deformed epidermal autoregulatory factor 1 homolog", "gene_name": "DEAF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDADSEAERETPRVTAVAVMAAEPGHMDMGAEALPGPDEAAAAAAFAEVTTVTVANVGAAADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKNRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKENELPTTPVKKDSPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEASVQPPCRASHPEPHYPGYQDSCQIAPFPEAALPTSHPKIVLTSLPALAVPPPTPTKAAPPALVNGLELSEPRSWLYLEEMVNSLLNTAQQLKTLFEQAKHASTYREAATNQAKIHADAERKEQSCVNCGREAMSECTGCHKVNYCSTFCQRKDWKDHQHICGQSAAVTVQADEVHVAESVMEKVTV", "length": 565 }, "evidence": [ { "id": "A0A3Q1LRM9", "url": "https://omabrowser.org/oma/group/A0A3Q1LRM9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q24180-1", "protein_name": "Deformed epidermal autoregulatory factor 1", "gene_name": "Deaf1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEQVDSSTELHLNRKDLAALAEDVVKEEVILESSSHHHHHHHHQLDTKVRMVTSSSNDNSGSGGASGGTSGAGGGNGGGGVVSVPVSLPIGSMITGTTFNVITPDQLPPHFKPMLCVDNNGYLSGSTVSMGNDLKTIVIQQQQTQPGGGGGGANNAGTNTTATNTIGLNHDGSGSNNSHDSLATLEHAAGGASGVGGGGGGTGGGSSGWSENPSTQHNEVFQIRCKTTCAELYRSKLGSGGRGRCVKYKDKWHTPSEFEHVCGRGSSKDWKRSIKYGGKSLQSLIDEGTLTPHATNCSCTVCCDDEAGESASGPVRLFTPYKRRKRNQTDLDMESGPKRKRNTHHSNNNNSNTNNNNTSGSGANNCVDVTAAVAAATASVVDENNMFLSEENITSKDEPWAALNDSLDTSTELVDQSQMGNTYERETFVVNINDGSSIAVLDTSQSMKNIEHVYCTMVKATNDFKRMLNDMKQSFERRIEVLQKERDAAVSAMRVQVHADIDDPNISGSLHGNEIISAKKCANCNREALAECSLCRKTPYCSEFCQRKDWNAHQVECTRNPQTTTQQVMLLIDDQS", "length": 576 }, "evidence": [ { "id": "A0A3Q1LRM9", "url": "https://omabrowser.org/oma/group/A0A3Q1LRM9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Z1T5-1", "protein_name": "Deformed epidermal autoregulatory factor 1 homolog", "gene_name": "Deaf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAESEAEEPVLSRDEDSEEDADSEAERETRRVTAVAVMAAESGHMDMGTEALPSPDEAAAAAAAFAEVTTVTVANVGSSADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKSRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKENELPTTPVKKDSPKNITLLPATAATTFTVTPSGQITTSGALTFDRASTVEATAVISESPAQGDVFAGATVQEAGVQPPCRVGHPEPHYPGYQDSCQIAPFPEAALPTSHPKIVLTSLPALAVPPSTPTKAVSPTVVSGLEMSEHRSWLYLEEMVNSLLNTAQQLKTLFEQAKQASSCREAAVTQARMQVDTERKEQSCVNCGREAMSECTGCHKVNYCSTFCQRKDWKDHQHVCGQSASVTVQADDVHVEESVIEKVAV", "length": 566 }, "evidence": [ { "id": "A0A3Q1LRM9", "url": "https://omabrowser.org/oma/group/A0A3Q1LRM9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulator complex", "id": "GO:0090575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090575", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" }, { "name": "visual learning", "id": "GO:0008542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008542", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" }, { "name": "neural tube closure", "id": "GO:0001843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001843", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" }, { "name": "behavioral fear response", "id": "GO:0001662", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001662", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" }, { "name": "regulation of mammary gland epithelial cell proliferation", "id": "GO:0033599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033599", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" }, { "name": "embryonic skeletal system development", "id": "GO:0048706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048706", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM9" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { 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"tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LRP0-1", "uniprot_ac": "A0A3Q1LRP0", "uniprot_id": "A0A3Q1LRP0_BOVIN", "mass": { "chemical_mass": 50690.0, "monoisotopic_mass": 50690.0 }, "refseq": { "ac": "NP_001180096", "name": "glucoside xylosyltransferase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180096" }, "gene_names": [ { "name": "GXYLT1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0" } ] }, { "name": "GLT8D3", "type": "synonym", "evidence": [ { "id": "NP_001180096", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180096" } ] }, { "name": "GXYLT1", "type": "synonym", "evidence": [ { "id": "NP_001180096", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180096" } ] } ], "protein_names": [ { "name": "Glucoside xylosyltransferase 1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0/entry#names_and_taxonomy" } ] }, { "name": "2.4.2.42", "type": "synonym", "evidence": [ { "id": "A0A3Q1LRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0/entry#names_and_taxonomy" } ] }, { "name": "Glycosyltransferase 8 domain-containing protein 3", "type": "synonym", "evidence": [ { "id": "A0A3Q1LRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0/entry#names_and_taxonomy" } ] }, { "name": "glucoside xylosyltransferase 1", "type": "synonym", "evidence": [ { "id": "NP_001180096", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180096" } ] }, { "name": "glycosyltransferase 8 domain containing 3", "type": "synonym", "evidence": [ { "id": "NP_001180096", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180096" } ] } ], "function": [ { "annotation": "Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRP0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0#function" }, { "database": "UniProtKB", "id": "ARBA00037301", "url": "https://www.uniprot.org/uniprotkb/ARBA00037301#function" }, { "database": "UniProtKB", "id": "E1BHD8", "url": "https://www.uniprot.org/uniprotkb/E1BHD8#function" }, { "database": "UniProtKB", "id": "A0ABI0P2Q5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2Q5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRP0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GXYLT1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0", "locus": { "chromosome": "5", "start_pos": 38592630, "end_pos": 38545409, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015024", "url": "https://www.ensembl.org/id/ENSBTAG00000015024" } ] } } ], "crossref": [ { "id": "A0A3Q1LRP0", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LRP0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015024", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015024", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06430", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06430", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617596", "url": "https://www.ncbi.nlm.nih.gov/gene/617596", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617596", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617596", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IPIHKEY", "url": "https://omabrowser.org/oma/group/IPIHKEY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LRP0", "url": "https://www.orthodb.org/?gene=A0A3Q1LRP0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BHD8", "url": "https://www.orthodb.org/?gene=E1BHD8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46012", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46012", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46012:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46012:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001180096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180096", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "56064", "url": "https://www.rhea-db.org/rhea/56064", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LRP0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRP0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2Q5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2Q5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2Q5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2Q5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHD8", "url": "https://www.uniprot.org/uniprotkb/E1BHD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHD8-1", "url": "https://www.uniprot.org/uniprotkb/E1BHD8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRYLRVVVLCLACGFCSLLYAFSQLAVSLEEGAGGVGGKPQAAAASWLGGDGRGAGRGVGSAGPAAHHGRSDRCKEFSLCYWNPYWMLPSDVCGMNCFWEAAFRYGVKMQPVERVHLAVVACGERLEETVTMLKSALIFSIKPLQFHIFAEDQLHDSFKGILDSWSFLQTFNYSLYPITFPSENAAEWKKLFKPCASQRLFLPLILKEVDSLLYVDTDILFLRPVDDIWALLKKFNSTQIAAMAPEHEEPRIGWYNRFARHPYYGKTGVNSGVMLMNMTRMRRKYFKNDMTTVRLRWGDILMPLLKKYKLNITWGDQDLLNIIFFHNPESLFVFPCQWNYRPDHCIYGSNCQEAEEEGIFILHGNRGVYHDDKQPAFRAIYEALRNCSFEDDSIHSLLKPLELELQKTVHTYCGKIYKIFIKQLTKSIQDRYDRPPKER", "length": 440, "header": "tr|A0A3Q1LRP0-1|A0A3Q1LRP0_BOVIN Isoform 1 of Glucoside xylosyltransferase 1 OS=Bos taurus OX=9913 GN=GXYLT1 PE=3 SV=2 CANONICAL=A0A3Q1LRP0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRP0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0/entry", "sequence": { "sequence": "MRRYLRVVVLCLACGFCSLLYAFSQLAVSLEEGAGGVGGKPQAAAASWLGGDGRGAGRGVGSAGPAAHHGRSDRCKEFSLCYWNPYWMLPSDVCGMNCFWEAAFRYGVKMQPVERVHLAVVACGERLEETVTMLKSALIFSIKPLQFHIFAEDQLHDSFKGILDSWSFLQTFNYSLYPITFPSENAAEWKKLFKPCASQRLFLPLILKEVDSLLYVDTDILFLRPVDDIWALLKKFNSTQIAAMAPEHEEPRIGWYNRFARHPYYGKTGVNSGVMLMNMTRMRRKYFKNDMTTVRLRWGDILMPLLKKYKLNITWGDQDLLNIIFFHNPESLFVFPCQWNYRPDHCIYGSNCQEAEEEGIFILHGNRGVYHDDKQPAFRAIYEALRNCSFEDDSIHSLLKPLELELQKTVHTYCGKIYKIFIKQLTKSIQDRYDRPPKER", "length": 440, "header": "tr|A0A3Q1LRP0-1|A0A3Q1LRP0_BOVIN Isoform 1 of Glucoside xylosyltransferase 1 OS=Bos taurus OX=9913 GN=GXYLT1 PE=3 SV=2 CANONICAL=A0A3Q1LRP0-1" }, "locus": { "chromosome": "5", "start_pos": 38591626, "end_pos": 38545608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071949.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071949.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059839.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059839.2" } ] } }, { "isoform_ac": "A0ABI0P2Q5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2Q5/entry", "sequence": { "sequence": "MRRYLRVVVLCLACGFCSLLYAFSQLAVSLEEGAGGVGGKPQAAAASWLGGDGRGAGRGVGSAGPAAHHGRSDRYGVKMQPVERVHLAVVACGERLEETVTMLKSALIFSIKPLQFHIFAEDQLHDSFKGILDSWSFLQTFNYSLYPITFPSENAAEWKKLFKPCASQRLFLPLILKEVDSLLYVDTDILFLRPVDDIWALLKKFNSTQIAAMAPEHEEPRIGWYNRFARHPYYGKTGVNSGVMLMNMTRMRRKYFKNDMTTVRLRWGDILMPLLKKYKLNITWGDQDLLNIIFFHNPESLFVFPCQWNYRPDHCIYGSNCQEAEEEGIFILHGNRGVYHDDKQPAFRAIYEALRNCSFEDDSIHSLLKPLELELQKTVHTYCGKIYKIFIKQLTKSIQDRYDRPPKER", "length": 409, "header": "tr|A0ABI0P2Q5-1|A0ABI0P2Q5_BOVIN Computationally mapped isoform of Glucoside xylosyltransferase 1 OS=Bos taurus OX=9913 GN=GXYLT1 PE=3 SV=1 CANONICAL=A0A3Q1LRP0-1" }, "locus": { "chromosome": "5", "start_pos": 38591626, "end_pos": 38545608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144089.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144089.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105683.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105683.1" } ] } }, { "isoform_ac": "E1BHD8-1", "url": "https://www.uniprot.org/uniprotkb/E1BHD8/entry", "sequence": { "sequence": "MRRYLRVVVLCLACGFCSLLYAFSQLAVSLEEGAGGVGGKPQAAAASWLGGDGRGAGRGVGSAGPAAHHGRSDRCKEFSLCYWNPYWMLPSDVCGMNCFWEAAFRYGVKMQPVERVHLAVVACGERLEETVTMLKSALIFSIKPLQFHIFAEDQLHDSFKGILDSWSFLQTFNYSLYPITFPSENAAEWKKLFKPCASQRLFLPLILKEVDSLLYVDTDILFLRPVDDIWALLKKFNSTQIAAMAPEHEEPRIGWYNRFARHPYYGKTGVNSGVMLMNMTRMRRKYFKNDMTTVRLRWGDILMPLLKKYKLNITWGDQDLLNIIFFHNPESLFVFPCQWNYRPDHCIYGSNCQEAEEEGIFILHGNRGVYHDDKQPAFRAIYEALRNLTFLYIKHDLPKSLCAGHSASEEGVIICVRRVSRRS", "length": 423, "header": "tr|E1BHD8-1|E1BHD8_BOVIN Computationally mapped isoform of Glucoside xylosyltransferase 1 OS=Bos taurus OX=9913 GN=GXYLT1 PE=3 SV=2 CANONICAL=A0A3Q1LRP0-1" }, "locus": { "chromosome": "5", "start_pos": 38589021, "end_pos": 38545608, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045528.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045528.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042909.3", "url": "https://www.ensembl.org/id/ENSBTAP00000042909.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:617596", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617596", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XEP1-1", "protein_name": "Glucoside xylosyltransferase 1", "gene_name": "GXYLT1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRRFARVALLFLGCGVCSLLYGVSQLALSLEQEAGGARQRQARESAAPGGGRQAGSADGGEEGAGRCKNLSVSFWNSYWMLPSDVCGVNCFWEAAFRYTYMKTQPSETMHLAVVACGERLEETITMLRSAIIFSIKPLHFHIFAEDQLHESFKDILDDFPYEGKVNYTLYPITFPSEGAKEWKKLFKPCASQRLFLPLILKDVDSLLYVDTDILFLRPVDDIWSFLRKFNSTQIAAMAPEHEEPRIGWYNRFARHPYYGVTGINSGVMLMNMTRIRRKYFKNDMTSVRLRWAEILMPLLKKYKLNITWGDQDLLNIMFFHNPESLYVFPCQWNYRPDHCIYGSNCKEAEEEGIFILHGNRGVYHDDKQPTFRAVYEAIKNYSFGDDLVRSLLQPLELELQKTVHTYCGRVYEVFIKQLKKSIKDLSVRRSKGS", "length": 433 }, "evidence": [ { "id": "A0A3Q1LRP0", "url": "https://omabrowser.org/oma/group/A0A3Q1LRP0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q3UHH8-1", "protein_name": "Glucoside xylosyltransferase 1", "gene_name": "Gxylt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRRYLRVVGLCLACGFCSLLYAFSQLAVSLEEGAAGGRRPQAAVVSWLADGGRGTGRGAGSAGPGRTGRYDMKTRPDEKMHLAVVACGERLEETVTMLKSALIFSIKPLHVHIFAEDQLHDSFKDRLASWSFLRRFDYSLYPITFPGDSAADWKKLFKPCASQRLFLPLILKEVDSLLYVDTDILFLRPVDDIWSLLKKFNSTQIAAMAPEHEEPRIGWYNRFARHPYYGRTGVNSGVMLMNMTRMRRKYFKNDMTTARLQWGDILMPLLKKYKLNITWGDQDLLNIVFSHNPESLFVFPCQWNYRPDHCIYGSNCREAEEEGVFILHGNRGVYHDDKQPAFRAVYEALRNCSLEDDSVRSLLKPLELELQKTVHTYCGKTYKIFIKQLTKSIRNRYDTPPKER", "length": 404 }, "evidence": [ { "id": "A0A3Q1LRP0", "url": "https://omabrowser.org/oma/group/A0A3Q1LRP0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q4G148-1", "protein_name": "Glucoside xylosyltransferase 1", "gene_name": "GXYLT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRRYLRVVVLCVACGFCSLLYAFSQLAVSLEEGTGGGGGKPQAAVASWLAGGGRGAVRGAGVAGPAAHPGVSDRCKDFSLCYWNPYWMLPSDVCGMNCFWEAAFRYSLKIQPVEKMHLAVVACGERLEETMTMLKSAIIFSIKPLQFHIFAEDQLHHSFKGRLDNWSFLQTFNYTLYPITFPSENAAEWKKLFKPCASQRLFLPLILKEVDSLLYVDTDILFLRPVDDIWSLLKKFNSTQIAAMAPEHEEPRIGWYNRFARHPYYGKTGVNSGVMLMNMTRMRRKYFKNDMTTVRLQWGDILMPLLKKYKLNITWGDQDLLNIVFFHNPESLFVFPCQWNYRPDHCIYGSNCQEAEEGGIFILHGNRGVYHDDKQPAFRAVYEALRNCSFEDDNIRSLLKPLELELQKTVHTYCGKIYKIFIKQLAKSVRDRYARSPKEK", "length": 440 }, "evidence": [ { "id": "A0A3Q1LRP0", "url": "https://omabrowser.org/oma/group/A0A3Q1LRP0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6GX83-1", "protein_name": "Glucoside xylosyltransferase 1", "gene_name": "Gxylt1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRRYLRVVGLCLACGFCSLLYAFSQLAVSLEEGAAVGRRPQAAVASWLADGGRGTGRGAGSAGPGRTGRCKEVSLSYWNPYWMLPSDVCGVNCFWEAAFRYGLKTRPTEKMHLAVVACGDRLEETVTMLKSALIFSIKPLHVHIFAEDQLHDSFKDRLDSWSFLQRFNYSLYPITFPSDSAMEWKKLFKPCASQRLFLPLILKGVDSLLYVDTDVLFLRPVDDIWSLLERFNSTQIAAMAPEHEEPRVGWYNRFARHPYYGRTGVNSGVMLMNMTRMRRKYFKNDMTTARLQWGDILMPLLKKYKLNITWGDQDLLNIMFYHNPESLFVFPCQWNYRPDHCIYGSNCREAEEEGVFILHGNRGVYHDDKQPAFRAMYEALRNCSLEDDSVRSLLKPLELELQKTVHTYCGKTYKIFIKQLAKSIRNRYDTPPKER", "length": 435 }, "evidence": [ { "id": "A0A3Q1LRP0", "url": "https://omabrowser.org/oma/group/A0A3Q1LRP0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRP0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein O-linked glycosylation via N-acetyl-galactosamine", "id": "GO:0016266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016266", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRP0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0" } ], "pmid": "" }, { "name": "protein O-linked glycosylation via glucose", "id": "GO:0180059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0180059", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRP0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity", "id": "GO:0140563", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140563", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRP0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0" } ], "pmid": "" }, { "name": "UDP-xylosyltransferase activity", "id": "GO:0035252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035252", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRP0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" }, { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "56064", "name": "", "equation": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LRP0-1", "G3N2G4-1" ], "evidence": [ { "id": "56064", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/56064" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LRP0", "gene_name": "GXYLT1", "activity": [ { "ec_number": "2.4.2.42", "activity": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP + H(+).", "evidence": [ { "id": "A0A3Q1LRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0" } ] }, { "ec_number": "2.4.2.42", "activity": "", "evidence": [ { "id": "A0A3Q1LRP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP0" } ] } ] }, { "uniprot_ac": "G3N2G4", "gene_name": "GXYLT2", "activity": [ { "ec_number": "2.4.2.42", "activity": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP + H(+).", "evidence": [ { "id": "G3N2G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2G4" } ] }, { "ec_number": "2.4.2.42", "activity": "", "evidence": [ { "id": "G3N2G4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2G4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LRP0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 440, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LRP0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LRP0" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G01629YL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G26821XH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G41179DF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G61224OH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G82156OL", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G86535WT", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G98229SM", "type": "Other", "subtype": "Other" } ], "enzyme_annotation": [ { "ec_number": "2.4.2.42", "ec_name": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP + H(+).", "evidence": [ { "id": "2.4.2.42", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.42" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 173, "end_pos": 175 }, { "start_pos": 237, "end_pos": 239 }, { "start_pos": 278, "end_pos": 280 }, { "start_pos": 312, "end_pos": 314 }, { "start_pos": 387, "end_pos": 389 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", 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"categories": [ "Protein Classification" ] }, { "id": "IPR026818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026831", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026831", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041257", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041257", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "AGKDCRM", "url": "https://omabrowser.org/oma/group/AGKDCRM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LRP9", "url": "https://www.orthodb.org/?gene=A0A3Q1LRP9", 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Classification", "Other" ] }, { "id": "PF11414", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11414", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16629", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16629", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16689", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16689", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18797", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18797", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005209385", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209385", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRP9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSSVAAYEQLVRQVEALKAENSHLRQELRDNSSHLSKLETETSGMKAVLQHLQGKLEQEARVLVSSGQTEVLEQLKALQMDITSLYNLKFQPPALAPEPTTRTPEGSPVHSSGPSKENFGELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVETQFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLSAQDRVQQTEPQALLAVKSMPMDEDAENEVPTHPEDGAPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAGAGGRNGTPGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDGGPEGSGTGAAPVPIEPQICQATCAVMKLSFDEEYRRAMNELGGLQAVAELLQVDHEMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKAALCARRGCMEAIVAQLASESEELHQVVSSILRNLSWRADINSKKVLREVGSMTALMQCVLRATKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVSSLIATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKYQPAATAVSPGSCAPSLYVRKQRALEAELDTRHLAQALDHLEKQGLPEAETACKKPLPPLRHLDGLAQDYASDSGCFDDDDAPSLAAAATAAEPASPAVLSLFLGSPFLQGQALARAPPTRRGGLEVEKEAGGEAAVAARAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSSRAHPLLRLKAAHASLSNDSLNSGSTSDGHCPREHSRPCSLAALAEHREGPPRGQARPSRLDLNLPGGQAEPEARDAKATDAHVRTIKLSPTYQHVPLLEGTTRAGAGSLAPGARKQAWLSTEGLSSVPEKLVVEKAPLCLSRCSSLSSLSSAGRPGPSEAGDLDESDSSLEGLEESGPGETELDGAWRGPGAASLPMAIPAPQRGRGLGVEDATPSSSSENCVQETPLVLSRCSSVSSLGSFESPSIASSIPSDPCSGLGSGTVSPSELPDSPGQTMPPSRSKTPPLAPAPPGEREATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCASSLSALALHELYVQKDVELRLLPPACPERGSGGGGGPGHRRRDEASGCLEGPASTDQELELLRECLGGAVPARLRKVASALVPGCRTLPVPVYMLVPAPAREDDSCTDSAEGTPVNFSSTASLSDETLQGPPKDGGRLDGKKPVGRAASTRQSAGQRHRVGGMGRSTEQPRGAGSGRAGLELPLRRPPSTCRDTDSSRPGQEHGDGALQSLCLTTPTEEAVYCFYGNDSDEEPATAVAAAPPRRASAIPRAVKRERPTGARKEVQAVPKAAPKAAPPARAQPSLIADETPPCYSLSSSASSLSEPEPSECMASRPRVHKPGLTKDLVPGGRKDGCPSPRAEAELLRRCIGSALPRRQPQVSGPRRRPPREAQPKARAAEGPRERGEEAASSDHASDLDSIEWRAIQEGANSVATWLHQAAAAAAREASSESDSVLSFATGQSVGSTLQPTVHRKGCRPRAERQAGGALRPEKPEGALTQRSSGPEKPRGTQKAPNGVPAVLRGHTVIYMPTPATRAQPRGAPGSRIVARKMGALSPVQPAAPTKAPNPGQQRSRSLHRPGKISELATLSPPQRSATPPARLAKTPSSSSSQTSPASQPLPRRSPPAAQPAGPLPGPRASPVPKTPARALLAKQHKTQKSPVRIPFMQRPARRGPPPLARAAPEPGPRGRVGAEGGSAARGGRLGLVRVASARSSGSESSDRSGFRRQLTFIKESPGLMRRRRSELSAPEATNPTTQAASPCRGRPALPAVFLCSSRCDELRAGSRQAPAPQRAHTARPRPSERQPRRTSSESPSRLPVRTPAAGPETVKRYASLPHISVARRPDATIPEPAADATRRSSAGEAGPLPRVAAPGTTWRRIRDEDVPHILRSTLPARALPLLGSPPEDGPAGPPQRKTSDAVVQTEDFAAAKTNSSTSPSMESRAPPEATAGGPTSLLGSDVDGPPSKAPAPIPFVPASRHGSPSRSARVPPFNYVPSPMVAATADSTVEKAPTPVPTSLLE", "length": 2253, "header": "tr|A0A3Q1LRP9-1|A0A3Q1LRP9_BOVIN Isoform 1 of Adenomatous polyposis coli protein 2 OS=Bos taurus OX=9913 GN=APC2 PE=3 SV=1 CANONICAL=A0A3Q1LRP9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRP9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP9/entry", "sequence": { "sequence": "MTSSVAAYEQLVRQVEALKAENSHLRQELRDNSSHLSKLETETSGMKAVLQHLQGKLEQEARVLVSSGQTEVLEQLKALQMDITSLYNLKFQPPALAPEPTTRTPEGSPVHSSGPSKENFGELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVETQFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLSAQDRVQQTEPQALLAVKSMPMDEDAENEVPTHPEDGAPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAGAGGRNGTPGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDGGPEGSGTGAAPVPIEPQICQATCAVMKLSFDEEYRRAMNELGGLQAVAELLQVDHEMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKAALCARRGCMEAIVAQLASESEELHQVVSSILRNLSWRADINSKKVLREVGSMTALMQCVLRATKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVSSLIATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKYQPAATAVSPGSCAPSLYVRKQRALEAELDTRHLAQALDHLEKQGLPEAETACKKPLPPLRHLDGLAQDYASDSGCFDDDDAPSLAAAATAAEPASPAVLSLFLGSPFLQGQALARAPPTRRGGLEVEKEAGGEAAVAARAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSSRAHPLLRLKAAHASLSNDSLNSGSTSDGHCPREHSRPCSLAALAEHREGPPRGQARPSRLDLNLPGGQAEPEARDAKATDAHVRTIKLSPTYQHVPLLEGTTRAGAGSLAPGARKQAWLSTEGLSSVPEKLVVEKAPLCLSRCSSLSSLSSAGRPGPSEAGDLDESDSSLEGLEESGPGETELDGAWRGPGAASLPMAIPAPQRGRGLGVEDATPSSSSENCVQETPLVLSRCSSVSSLGSFESPSIASSIPSDPCSGLGSGTVSPSELPDSPGQTMPPSRSKTPPLAPAPPGEREATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCASSLSALALHELYVQKDVELRLLPPACPERGSGGGGGPGHRRRDEASGCLEGPASTDQELELLRECLGGAVPARLRKVASALVPGCRTLPVPVYMLVPAPAREDDSCTDSAEGTPVNFSSTASLSDETLQGPPKDGGRLDGKKPVGRAASTRQSAGQRHRVGGMGRSTEQPRGAGSGRAGLELPLRRPPSTCRDTDSSRPGQEHGDGALQSLCLTTPTEEAVYCFYGNDSDEEPATAVAAAPPRRASAIPRAVKRERPTGARKEVQAVPKAAPKAAPPARAQPSLIADETPPCYSLSSSASSLSEPEPSECMASRPRVHKPGLTKDLVPGGRKDGCPSPRAEAELLRRCIGSALPRRQPQVSGPRRRPPREAQPKARAAEGPRERGEEAASSDHASDLDSIEWRAIQEGANSVATWLHQAAAAAAREASSESDSVLSFATGQSVGSTLQPTVHRKGCRPRAERQAGGALRPEKPEGALTQRSSGPEKPRGTQKAPNGVPAVLRGHTVIYMPTPATRAQPRGAPGSRIVARKMGALSPVQPAAPTKAPNPGQQRSRSLHRPGKISELATLSPPQRSATPPARLAKTPSSSSSQTSPASQPLPRRSPPAAQPAGPLPGPRASPVPKTPARALLAKQHKTQKSPVRIPFMQRPARRGPPPLARAAPEPGPRGRVGAEGGSAARGGRLGLVRVASARSSGSESSDRSGFRRQLTFIKESPGLMRRRRSELSAPEATNPTTQAASPCRGRPALPAVFLCSSRCDELRAGSRQAPAPQRAHTARPRPSERQPRRTSSESPSRLPVRTPAAGPETVKRYASLPHISVARRPDATIPEPAADATRRSSAGEAGPLPRVAAPGTTWRRIRDEDVPHILRSTLPARALPLLGSPPEDGPAGPPQRKTSDAVVQTEDFAAAKTNSSTSPSMESRAPPEATAGGPTSLLGSDVDGPPSKAPAPIPFVPASRHGSPSRSARVPPFNYVPSPMVAATADSTVEKAPTPVPTSLLE", "length": 2253, "header": "tr|A0A3Q1LRP9-1|A0A3Q1LRP9_BOVIN Isoform 1 of Adenomatous polyposis coli protein 2 OS=Bos taurus OX=9913 GN=APC2 PE=3 SV=1 CANONICAL=A0A3Q1LRP9-1" }, "locus": { "chromosome": "7", "start_pos": 43875951, "end_pos": 43858777, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077910.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077910.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057735.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057735.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1121, "start_aa": "Thr", "end_pos": 1121, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1121", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1764, "start_aa": "Thr", "end_pos": 1764, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1764", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AJ26-1", "protein_name": "Adenomatous polyposis coli protein 2", "gene_name": "APC2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGLRGLLALLRAAAPSAGDEALEELKMSGAASYEQLVRQVEALRRENSHLRRELQDNSQHLSKLENETSDMKEVLKHLQGKLEQEARVMVSSGQTEVLEQLKALQMDISSLYSLKFPEVAVGVGEDSPQHSTPHGDSAGDVGRATLQLLEELDRERCFLLGEIEKEEKEKVWYYAQLQSLSKRLEELPHVETFSMQMDLIRQQLQFEAQHIRALMEERFGTADEMVQRAQIRASRLEQIDKELMEAQDKVQPPEPQLCTKLPGTEEDSSMDVPTHPEDGGSSKVEVVFWLLSMLATRDKDDMSRTLLAMSSSQESCLAMRKSGCLPLLIQILHDSDREPGPPESPSSSKDARMRANAALHNIVFSQPDEGQAKKEMRVLHVLEQIRSYSETCWDWLQMQSRDGGKGPEGGAEPVPIEPQICQATCAIMKLSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTSDPLNLALRRYAGMALTNLTFGDVVNKATLCSRRGCMEAIVAQLGSDSEELHQVVSSILRNLSWRADINSKKVLREVGSVAGLTQCALHAAKESTLKSVLSALWNLSAHSTENKAAICGVEGALGFLVSTLTYKCQSNSLAIIESGGGILRNVSSLIATREDYRQVLRDHNCLQTLLQHLRSHSLTIVSNACGTLWNLSARSPRDQELLWDLGAVSMLRNLIHSKHKMIAMGSAAALRNLLTNRPPKYKDTAVVSPGSCMPSLYMRKQKALEAELDAKHLAETFDTMEKQSLKSQSAKKPLRHMESLVKDYASDSGCFDDDEVPNISTGVETASASVLSMFLGSSFLQGQALPRALAQRRCPEPEKDDGGKPTEPKKPPLPEDDVSLAAEKLANKISSTVAKIDKLVEDISTMHTSSDDSFSLSSEDHGLDWQYGPEEPPEARAHSCSPCRLSDTGGSARREGLSRARALLRLKTAYTSLSTDSLNSGSTSDGYCPKEHMKPCTRAPFLDYRDELQRYQKRPSRLDLKSILGTKPDPPVLRAEPDKPEQREVPERGRKAVTFPGPKALEIGRKKETGGKLPTDPQVHTIKLSPSYQHVPLLGSLAKSSTAVSHHPSLLGRKQAWLPPALLQTAETLSKIPEKLPAQPLAAAEQESVQKYSVEDTPICFSRCSSLSSLSSADNVLDGQSHSENDLDSDSSLEILEMDEGDGEAEDMRREKEKAEMGPTTPVGISQPITIPFPKRDKLFLRDASPSRQEDHTPSSSSENYIQETPLVMSRCSSVSSLGSFESPSIASSIQSDPCSEMISGTVSPSELPDSPGQTMPPSRSKTPLFELGCPPEKETSQFNIQWENNVKKFMEITDFKERFQLPQDLDSMVYFTVEKPNENFSCASSLSALPLHEHYVQKDVELKLMPTFPEKNSLNFAAHEEREEREEQLLEGRRRAEPTSDDDIEILKECISSAMPSRFRKVKSSLLSGQVLHPHTKKPLHVPVYMLVPAHTAVPKHLRATSRELYKDDDSYTDSADGTPVNFSSTASLSDETLRGPKEESEPPRGAGRRREVGTAASPARRSALGSAAPTRPSSACRGRAGSSRDSPVPPGRGAEGKRGQPMAGTEPDVGRSGSPGTRPCSLPGRKDGVREDGAAFQSLCHTTPTEEAVYCFYEHDSDEPGVGKEVPGGGAQPGRALRRERCGGSVPRREPEAKGKAKGKLQHNLIADETPPCYSLSSSMSSLSDGDPGEGEERGSAPRQRAAVGQAQGRSPSPNSEDDLLQKCIGSAMPKRRRPSTRRRTAERKQKLKGGAGRERTAEGRHRSEDLGSDGGSDLDSVEWEAIQEGANSIVTWLHQAAASLSREPSSESDSILSFVSGLSVGSTLQLSLDRTEKKRSGSAAGREVERRERAKSRPEGKKAPSARPAGSTRAERSPAPSKPVPNLPVVFRGRTVIYMPSLAKDAPSPRSTPKKSPVAKPPAPKNLSLSQQRSRSLHRLGKPPEGGDLALPKRSTTPPARIAKGPPSSGSSRTSTPSQHVPKKLPSPSQHPKQSPAQTGKATGPPSPPGPSAKPTAPRSPAPRQHKTQKSPVRIPFMQKPSRKVLPVRAAMPVLEEQEGSGKAKGSAPGGAGGGRLNLVRMSSARSSGSDSDRSGFLRQLTFIKESSSLLLRHRAELAPPAPATSLPRGASPQRSRAALPTVFLCSSRCEELKAAKAAAPTARPLIPRAQPGCKAPAASKPPRRTSSESPSRLPVKTAVPEPFKRYSSSPNISVPRRTGSPSSVLSVCSEASARRRKAGEATEEKPPTAVMKGTWRRIRDEDIPHILQSTLPSTALPLLGAAEEPSPGPRKTSDAVVQTEDFATTKTNSSTSPTMETPRRDGEAPAPTKAALPISFGHEAPAGTFPASRHSSPSRAARVTPFNYVPSPMAVPAVADKAVEKIQA", "length": 2394 }, "evidence": [ { "id": "A0A3Q1LRP9", "url": "https://omabrowser.org/oma/group/A0A3Q1LRP9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LAD0-1", "protein_name": "Adenomatous polyposis coli protein 2", "gene_name": "Apc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLVVGTSYIEEQHQVWLGTSHRSACGDRCPLPAKPLFLLARHGKGGQLQPGVRLDLRLYSSSKFGLDGMSRSPQNLLSALEWARGGFSPPFRWIHQGTERGQALQELKMASSVASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARVLVSSGQTEVLEQLKALQTDISSLYNLKFHAPALGPEPAAQTPEGSPVHGPAPSKDSFGELSRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQGLSKRLDELPHVDTFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQALLAVKPVAVEEQEAEVPTHPEDVTPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAGSVGRTGTPGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTESGTGDTPVPIEPQICQAACAVMKLSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTQDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLASESEELHQVVSSILRNLSWRADINSKKVLREVGSMTALMECVLRASKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYRCQGNSLAVIESGGGILRNVSSLIATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKYQAAAMAVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQGLPEAETTSKKPLPPLRHLDGLVQDYASDSGCFDDDDAPSLAAAATTAEPASPAVMSMFLGGPFLQGQALARTPPARQGGLEAEKETGGEAAVAAKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGTEGGRREAGSRAHPLLRLKAAHTSLSNDSLNSGSTSDGYCTREHMTPCPLAVLTEHRDGPVCGQTRPSRLDLDLPSRAELPARDTAATDARVRTIKLSPTYQHVPLLDGAPGAGVRPLVGLGTSPGTRKQAWIPADSLSKVPEKLVASPLPVTSKVLQKLVAQDGPMSLSRCSSLSSLSSTGHAVPSQVENLDDSDSSLEELEEAGPGEAELDRAWRASGSTSLPVSIPAPQRGRSRGLGVEDATPSSSSENCVQETPLVLSRCSSVSSLGSFESRSIASSIPSDPCSALGSGTVSPSELPDSPGQTMPPSRSRTPPAPPGQPEASQFSLQWESYVKRFLDIADCRERCQPPSELDAGSVRFTVEKPDENFSCASSLSALALHELYVQQDVELRLRPPACPERAVGGGGGHRRRDEATSRLDGPAPAGSRARSAADKELEALRECLGAAMPARLRKVASALVPGRRALPVPVYMLVPAPARGDDSGTDSAEGTPVNFSSAASLSDETLQGPSRDKPARPGDRQKPTGRAAPARQTRGHRPKAAGAGAGKSTEHTRGANRNRAGLELPLSRPQSARSNRDGSCQTRTRGDGALQSLCLTTPTEEAVYCFYDSDEEPPATAPPTRRASAIPRALKREKPAGRKETPTRATQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPEASEQPACHPRVEEQGSKQDSSPRAEEELLQRCISLAMPRRRTQVPSSRRRKPRAVRSDIRPTELPQKCREEVPGSDPASDLDSVEWQAIQEGANSIVTWLHQAAAKASLEASSESDSLLSLVSGLSASSTLQPSKLRKGRKPVAEAGGAWRPEKRGTTSTKGSGSPRFPSGPEKAKGTQKTMAGESAMLRGRTVIYTASPASRAQSKGISGPCSAPKKMGTSGTTQPETATKTPSPEQQRSRSLHRPGKISELAALSHPPRSATPPARLTKTPSSSSSQTSPASQSLPRRSPLATPTGGPLPGPGGSPVPKSPARALLAKQHKTQKSPVRIPFMQRPARRVPPPLARPSPEPGSRGRAGAEGTPGARGSRLGLVRVASTRSSGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSADSTVSTSQTASPCRGRPALPAVFLCSSRCDELRASPRQPLAAQRVPQAKPGLAPRAPRRTSSESPSRLPVRATPGRPETVKRYASLPHISVSRRPDSAVSVPTTQANATRRGSDGEARPLPRVAAPGTTWRRIKDEDVPHILRSTLPATALPLRGSSPEDSPAGTPHRKTSDAVVQTEDVATSKTNSSTSPSLESRDPPQAPISGPVAPLGSDVDGPVLAKPPASAPFTHEGLSVVTGGFPTSRHGSPSRAARVPPFNYVPSPMVVATMTSDSAVEKAPVTSPASLLE", "length": 2388 }, "evidence": [ { "id": "A0A3Q1LRP9", "url": "https://omabrowser.org/oma/group/A0A3Q1LRP9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LC21-1", "protein_name": "Adenomatous polyposis coli protein 2", "gene_name": "APC2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTSSMAPYEQLVRQVEALKAENSHLRQELRDNSSHLSKLENETSGMKEVLKHLQGKLEQEARALVSSGQTEVLEQLKALQMDITSLYNLKFQPPALAPEPAARTPDGSPVHSSGPSKDNFGELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVETQFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLSAQDRVQQTEPQALLAVKSVPMDEDPETEVPTHPEDGAPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAGVGGRNGAPGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQTRNSGPEGAGAGGAPVPIEPQICQATCAVMKLSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLASESEELHQVVSSILRNLSWRADINSKKVLREVGSMTALMQCVLRASKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVSSLIATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKYQAAATAISPGACVPSLYVRKQRALEAELDARHLAQALDHLEKQGLPEAEAASKKPLPPLRHLDGLAQDYASDSGCFDDDDAPSLAAAAATATAEPASPAMLSLFLGSPFLQGQALARAPTARRGGLETEKETGGEAAVAARAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPDGGRREASSRAHPLLRLKAGHTSLSNDSLNSGSTSDGHCPREHSRPCPLVTLAEHREGPPCGQARPSRLDLGLANGKPEPAARDTTATDAHVRTIKLSPTYQHVPLLEGTTRVGAGSLAPGARKQAWLPTEGLSKAPEKLAVETAPLSLSHCSSLSSLSSAGRPGPSEAGDLDDSDSSLEGLEEAGPSEAELEGAWRGPVAASLPMAIPAPRRGRGLGLEDATPSSSSENCVQETPLVLSRCSSVSSLGSFESPSIASSIPSDPCSGLGSGTVSPSELPDSPGQTMPPSRSKTPPLAQAPPGEREATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCASSLSALALHELYVQKDVELRLLPPTCPERSSGGGGGPGHRRRDETGGRLEGPPSTDQELELLRECLGGAVPARLRKVASALMPGRRALPVPVYMLVPAPAREDDSCTDSADGTPVNFSSAASLSDETLQGPSRNSGRVEGEKPAGRATPSRQPTGHRHRAGGVGRSLEQPRGAGRSRAGLDLPLRRPPSTCGDKDGSRPGQVHGDGARQSLCLTTPTEEAVYCFYGNDSDEEPSTRVAAAPPRRASAIPRAVKRERLVGGRKEVQAVPKAAPKAAPPARAQPSLIADETPPCYSLSSSASSLSDPEPSEHAANWSRAREPGVTKDPGPGGRRDGSPSPRAEAELLRRCIGSAMPRRQPQVSGPRRRQPQPQPQAAQSEERPAEGPRELGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAAATREASSESDSVLSFASGLSVGSTLQHSLHRKGRRPRAEGQAGSTKRPEKGDTALAQRSSGPEKPRGTQKTASGVPAVLRGRTVIYVPSPATRAQPRGAPGPRAVPRKMGAPSAVQPAAPGPGQQRSRSLHRPGKISELAALSPPQRSATPPARLAKTPSSSSSQTSPASQPLPKRSPPAAQATGPLPGPGASPVPKTPARALLAKQHKTQKSPVRIPFMQRPARRGPPPLARAAPEPGPRGRAGSEGGPATRGGRLGLVRVASARSTGSESSDRSGFRRQLTFIKESPGLLRRRRSDLSAPEAPTPATQAGSPRRGRPALPAVFLCSSRCDELRAPRQAPASQRPPAARTGAGERPPRRTSSESPSRLPVRTPAARPETVKRYASLPHISVARRPDAAAPRPVVDAARRSSDGEARPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLIGSSPEEGPAGPPQRKTSDAVVQTEDFAATKTNSSTSPSLESRAPPQATAGGPTSLLGSDVDGPGPTKAPATAPFIHEGLGVAAGVFPASRHGSPSRAARVPPFNYVPSPMVAATTDSAVEKAPAPAPTSLLE", "length": 2265 }, "evidence": [ { "id": "A0A3Q1LRP9", "url": "https://omabrowser.org/oma/group/A0A3Q1LRP9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O95996-1", "protein_name": "Adenomatous polyposis coli protein 2", "gene_name": "APC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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}, { "name": "intercellular bridge", "id": "GO:0045171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045171", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP9" } ], "pmid": "" }, { "name": "catenin complex", "id": "GO:0016342", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016342", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP9" } ], "pmid": "" }, { "name": "lamellipodium membrane", "id": "GO:0031258", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031258", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP9" } ], "pmid": "" }, { "name": "filamentous actin", "id": "GO:0031941", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031941", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRP9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRP9" } ], "pmid": "" }, { "name": "cytoplasmic 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Pathway" ] }, { "id": "A0A3Q1LRX1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRX1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRX1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1F2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1F2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1F2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1F2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THL8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "PGPRARTPFTVPGSALPNTGSRRLWAGPSKSGGQRVAPERRGQLWVPARHSRLRDPPHSPQGCGGVRRPGADRGRKAGRGGAAGPGGAGRPTPGVEPSAPGPLLSARVGCPRDALGPRLHGAPAWPALLAAAPARGCLLRDPGRPVLLGGGVAPGAPNRSQNLLCRHPLSLAVQRHPRFRNLFNLSTPVLLSGDLFTPQLWDSLSQHKAPYGWQGLSHQAITSTLSLLNGSESTRLFAVSRELLPGCIRCAVVGNGGILNGSRQGQNIDAHDYVFRLNGAVIKGFENDVGTKISFYGFTVNTMKNSLISYSNVGFTSVPQGQYLRYIFIPSDIRDYLMLRSAILGVPVPEGTDKGDRPQTYFGLDSSASKFRLLHPDFISYLTERFLKSKLINTKFGDLYMPSTGALMLLTALHTCDQVSAYGFITSNYQKFSDHYFDRMKKPLIFYANHDLSLEATLWRDLHKAGILWLYQR", "length": 473, "header": "tr|A0A3Q1LRX1-1|A0A3Q1LRX1_BOVIN Isoform 1 of alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase OS=Bos taurus OX=9913 GN=ST6GALNAC2 PE=3 SV=2 CANONICAL=A0A3Q1LRX1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRX1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRX1/entry", "sequence": { "sequence": "PGPRARTPFTVPGSALPNTGSRRLWAGPSKSGGQRVAPERRGQLWVPARHSRLRDPPHSPQGCGGVRRPGADRGRKAGRGGAAGPGGAGRPTPGVEPSAPGPLLSARVGCPRDALGPRLHGAPAWPALLAAAPARGCLLRDPGRPVLLGGGVAPGAPNRSQNLLCRHPLSLAVQRHPRFRNLFNLSTPVLLSGDLFTPQLWDSLSQHKAPYGWQGLSHQAITSTLSLLNGSESTRLFAVSRELLPGCIRCAVVGNGGILNGSRQGQNIDAHDYVFRLNGAVIKGFENDVGTKISFYGFTVNTMKNSLISYSNVGFTSVPQGQYLRYIFIPSDIRDYLMLRSAILGVPVPEGTDKGDRPQTYFGLDSSASKFRLLHPDFISYLTERFLKSKLINTKFGDLYMPSTGALMLLTALHTCDQVSAYGFITSNYQKFSDHYFDRMKKPLIFYANHDLSLEATLWRDLHKAGILWLYQR", "length": 473, "header": "tr|A0A3Q1LRX1-1|A0A3Q1LRX1_BOVIN Isoform 1 of alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase OS=Bos taurus OX=9913 GN=ST6GALNAC2 PE=3 SV=2 CANONICAL=A0A3Q1LRX1-1" }, "locus": { "chromosome": "19", "start_pos": 55193024, "end_pos": 55174631, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078008.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078008.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059939.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059939.2" } ] } }, { "isoform_ac": "A0AAA9T1F2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1F2/entry", "sequence": { "sequence": "MGLQRGRLFWPLLLLAAVCSGILVALYSSAVELHLGPRTEARNTTSSSQAFFGPKAPNSRTRKNLLCRHPLSLAVQRHPRFRNLFNLSTPVLLSGDLFTPQLWDSLSQHKAPYGWQGLSHQAITSTLSLLNGSESTRLFAVSRELLPGCIRCAVVGNGGILNGSRQGQNIDAHDYVFRLNGAVIKGFENDVGTKISFYGFTVNTMKNSLISYSNVGFTSVPQGQYLRYIFIPSDIRDYLMLRSAILGVPVPEGTDKGDSPAPTGPSTATAPAPFTSPHSTTRRTTPRAALFTSIVGPRPQTYFGLDSSASKFRLLHPDFISYLTERFLKSKLINTKFGDLYMPSTGALMLLTALHTCDQVSAYGFITSNYQKFSDHYFDRMKKPLIFYANHDLSLEATLWRDLHKAGILWLYQR", "length": 414, "header": "tr|A0AAA9T1F2-1|A0A3Q1LRX1_BOVIN Computationally mapped isoform of alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase OS=Bos taurus OX=9913 GN=ST6GALNAC2 PE=3 SV=1 CANONICAL=A0A3Q1LRX1-1" }, "locus": { "chromosome": "19", "start_pos": 55193024, "end_pos": 55174989, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109810.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109810.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089483.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089483.1" } ] } }, { "isoform_ac": "A0AAA9THL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THL8/entry", "sequence": { "sequence": "EARAALGAGATLSPPGPAAQPPRVRRRPEAGSRQRKKGGAGRGGGAGRGRTADSGSRAQRTRASPLRPGRLPTGRPRAKAAWGSSVAGSSGRCSCSRLSAPGSWSPCTPRRWSCTWGPEPKPAITSTLSLLNGSESTRLFAVSRELLPGCIRCAVVGNGGILNGSRQGQNIDAHDYVFRLNGAVIKGFENDVGTKISFYGFTVNTMKNSLISYSNVGFTSVPQGQYLRYIFIPSDIRDYLMLRSAILGVPVPEGTDKGDRPQTYFGLDSSASKFRLLHPDFISYLTERFLKSKLINTKFGDLYMPSTGALMLLTALHTCDQVSAYGFITSNYQKFSDHYFDRMKKPLIFYANHDLSLEATLWRDLHKAGILWLYQR", "length": 376, "header": "tr|A0AAA9THL8-1|A0A3Q1LRX1_BOVIN Computationally mapped isoform of alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase OS=Bos taurus OX=9913 GN=ST6GALNAC2 PE=3 SV=2 CANONICAL=A0A3Q1LRX1-1" }, "locus": { "chromosome": "19", "start_pos": 55193024, "end_pos": 55174747, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125739.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125739.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098017.2", "url": "https://www.ensembl.org/id/ENSBTAP00000098017.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 92, "start_aa": "Thr", "end_pos": 92, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr92", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-4085001", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085001", "resource": "Reactome", "description": "Sialic acid metabolism" }, { "id": "R-BTA-977068", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977068", "resource": "Reactome", "description": "Termination of O-glycan biosynthesis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRX1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRX1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein O-linked glycosylation", "id": "GO:0006493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006493", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRX1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRX1" } ], "pmid": "" }, { "name": "glycoprotein biosynthetic process", "id": "GO:0009101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009101", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRX1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRX1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "id": "GO:0001665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001665", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRX1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRX1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" }, { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11136", "name": "", "equation": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N6V7-1", "A0A3Q1LRX1-1" ], "evidence": [ { "id": "11136", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11136" } ] }, { "id": "81643", "name": "", "equation": "a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LRX1-1", "F1N6V7-1" ], "evidence": [ { "id": "81643", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/81643" } ] }, { "id": "81659", "name": "", "equation": "a 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LRX1-1", "F1N6V7-1" ], "evidence": [ { "id": "81659", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/81659" } ] }, { "id": "R-BTA-4084980", "name": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [ "R-ALL-4086301" ], "output_participant_list": [ "R-ALL-4086341" ], "enzyme_list": [ "F1N6V7-1", "G3N3B2-1", "A0A3Q1LRX1-1" ], "evidence": [ { "id": "R-BTA-4084980", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4084980" } ] }, { "id": "R-BTA-981814", "name": "ST6GALNAC2 transfers sialic acid to Core 1 mucins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LRX1-1" ], "evidence": [ { "id": "R-BTA-981814", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-981814" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-4086301", "participant_name": "GalNAc-R [Golgi lumen]", "crossref": [ { "id": "21507", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-4086341", "participant_name": "Neu5Ac-2,6-GalNAc-R [Golgi lumen]", "crossref": [ { "id": "62634", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LRX1", "gene_name": "ST6GALNAC2", "activity": [ { "ec_number": "2.4.3.3", "activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "A0A3Q1LRX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRX1" } ] }, { "ec_number": "2.4.3.3", "activity": "", "evidence": [ { "id": "A0A3Q1LRX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRX1" } ] } ] }, { "uniprot_ac": "F1N6V7", "gene_name": "ST6GALNAC1", "activity": [ { "ec_number": "2.4.3.3", "activity": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+).", "evidence": [ { "id": "F1N6V7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6V7" } ] }, { "ec_number": "2.4.3.3", "activity": "", "evidence": [ { "id": "F1N6V7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6V7" } ] } ] }, { "uniprot_ac": "G3N3B2", "gene_name": "ST6GALNAC4", "activity": [ { "ec_number": "2.4.3.7", "activity": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc derivative + CMP + H(+).", "evidence": [ { "id": "G3N3B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B2" } ] }, { "ec_number": "2.4.3.7", "activity": "", "evidence": [ { "id": "G3N3B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B2" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LRX1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 473, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LRX1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LRX1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G00030VN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00041IL", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00063MO", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G00520NI", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00743WU", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G00745CN", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00803TF", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01040ZV", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01155GN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01203BZ", "type": "O-linked", "subtype": "Core 8" }, { "glytoucan_ac": "G01287FH", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01325OU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G01376HR", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01445XB", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G01546PE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01614ZM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G01657UH", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G01665LU", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G02244ID", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G02387FV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G02473HY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G02860LZ", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G02915XR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G03172PR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G03325JN", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03542TR", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G03819IX", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G03834RX", "type": "N-linked", "subtype": "Other" }, { "glytoucan_ac": "G03998SF", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G04267XF", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G04289KQ", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G04483QG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G04513DL", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G04548YV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G04706FE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G04743RS", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04895YD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G05106AU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G05235KE", "type": "O-linked", "subtype": "Core 5" }, { "glytoucan_ac": "G05374TU", "type": "O-linked", 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"count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LRY5-1", "uniprot_ac": "A0A3Q1LRY5", "uniprot_id": "A0A3Q1LRY5_BOVIN", "mass": { "chemical_mass": 66215.0, "monoisotopic_mass": 66215.0 }, "refseq": {}, "gene_names": [ { "name": "CHKA", "type": "recommended", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ] } ], "protein_names": [ { "name": "Ethanolamine kinase", "type": "recommended", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5/entry#names_and_taxonomy" } ] }, { "name": "2.7.1.32", "type": "synonym", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5/entry#names_and_taxonomy" } ] }, { "name": "2.7.1.82", "type": "synonym", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRY5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHKA", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5", "locus": { "chromosome": "29", "start_pos": 45579788, "end_pos": 45639898, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010304", "url": "https://www.ensembl.org/id/ENSBTAG00000010304" } ] } } ], "crossref": [ { "id": "A0A3Q1LRY5", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LRY5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010304", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010304", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05156", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05156", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EAPYYKI", "url": "https://omabrowser.org/oma/group/EAPYYKI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR22603", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22603", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22603:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22603:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01633", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01633", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1483191", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483191", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1483213", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483213", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "12837", "url": "https://www.rhea-db.org/rhea/12837", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "13069", "url": "https://www.rhea-db.org/rhea/13069", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LRY5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRY5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGD1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGD1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI39", "url": "https://www.uniprot.org/uniprotkb/F1MI39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI39-1", "url": "https://www.uniprot.org/uniprotkb/F1MI39-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRGRRAAANQRRARGRAVTRPALLVRRRYRSERHGERDQPSAAAAAAAARRSLPPRRRPAPVRRAPSRPRPGPARQRGGKRPRCPASVRGASGRTLSLAFTRCGRPRLLGRLPGMKTKFCNGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDGASDREPKQLGGRQPPLALPPPPPPPLPLPPPPPPPPPADDQPELRTRRRAYLWCKEFLPGAWRGLREDQFHISVIRGGLSNMLFQCSLPDTLATVGDEPRKVLLRLYGAILKMRSCNKEGSEQAQKDSEFQGAEAMVLESVMFAILAERSLGPKLFGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMARFHGMKMPFNKEPKWLFGTMEKYLNQVLRIRFTGESKVKQLHRFLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLDGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYNYEKYPFFRANILKYPTRKQQLHFISNYLAAFQNEFENLSNEEKSVIEEEMLLEVNRSTPKPGLMPTSTRRGSSGCDHVRPSCLHPWMAWGQPSPRPLCAPTTVPTAGRLRRLAAQHRRV", "length": 587, "header": "tr|A0A3Q1LRY5-1|A0A3Q1LRY5_BOVIN Isoform 1 of Ethanolamine kinase OS=Bos taurus OX=9913 GN=CHKA PE=3 SV=1 CANONICAL=A0A3Q1LRY5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRY5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5/entry", "sequence": { "sequence": "MRRGRRAAANQRRARGRAVTRPALLVRRRYRSERHGERDQPSAAAAAAAARRSLPPRRRPAPVRRAPSRPRPGPARQRGGKRPRCPASVRGASGRTLSLAFTRCGRPRLLGRLPGMKTKFCNGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDGASDREPKQLGGRQPPLALPPPPPPPLPLPPPPPPPPPADDQPELRTRRRAYLWCKEFLPGAWRGLREDQFHISVIRGGLSNMLFQCSLPDTLATVGDEPRKVLLRLYGAILKMRSCNKEGSEQAQKDSEFQGAEAMVLESVMFAILAERSLGPKLFGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMARFHGMKMPFNKEPKWLFGTMEKYLNQVLRIRFTGESKVKQLHRFLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLDGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYNYEKYPFFRANILKYPTRKQQLHFISNYLAAFQNEFENLSNEEKSVIEEEMLLEVNRSTPKPGLMPTSTRRGSSGCDHVRPSCLHPWMAWGQPSPRPLCAPTTVPTAGRLRRLAAQHRRV", "length": 587, "header": "tr|A0A3Q1LRY5-1|A0A3Q1LRY5_BOVIN Isoform 1 of Ethanolamine kinase OS=Bos taurus OX=9913 GN=CHKA PE=3 SV=1 CANONICAL=A0A3Q1LRY5-1" }, "locus": { "chromosome": "29", "start_pos": 45639699, "end_pos": 45580705, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082323.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082323.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059955.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059955.1" } ] } }, { "isoform_ac": "A0A3Q1MGD1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGD1/entry", "sequence": { "sequence": "MRRGRRAAANQRRARGRAVTRPALLVRRRYRSERHGERDQPSAAAAAAAARRSLPPRRRPAPVRRAPSRPRPGPARQRGGKRPRCPASVRGASGRTLSLAFTRCGRPRLLGRLPGMKTKFCNGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDGASDREPKQLGGRQPPLALPPPPPPPLPLPPPPPPPPPADDQPELRTRRRAYLWCKEFLPGAWRGLREDQFHISVIRGGLSNMLFQCSLPDTLATVGDEPRKVLLRLYGAILKMGAEAMVLESVMFAILAERSLGPKLFGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMARFHGMKMPFNKEPKWLFGTMEKYLNQVLRIRFTGESKVKQLHRFLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLDGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYNYEKYPFFRANILKYPTRKQQLHFISNYLAAFQNEFENLSNEEKSVIEEEMLLEVNRFALASHFFWGLWSIVQAKISSIEFGYMEYAQARFDAYFDQKRKLGV", "length": 552, "header": "tr|A0A3Q1MGD1-1|A0A3Q1LRY5_BOVIN Computationally mapped isoform of Ethanolamine kinase OS=Bos taurus OX=9913 GN=CHKA PE=3 SV=1 CANONICAL=A0A3Q1LRY5-1" }, "locus": { "chromosome": "29", "start_pos": 45639699, "end_pos": 45580838, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071805.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071805.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073309.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073309.1" } ] } }, { "isoform_ac": "F1MI39-1", "url": "https://www.uniprot.org/uniprotkb/F1MI39/entry", "sequence": { "sequence": "MRRGRRAAANQRRARGRAVTRPALLVRRRYRSERHGERDQPSAAAAAAAARRSLPPRRRPAPVRRAPSRPRPGPARQRGGKRPRCPASVRGASGRTLSLAFTRCGRPRLLGRLPGMKTKFCNGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDGASDREPKQLGGRQPPLALPPPPPPPLPLPPPPPPPPPADDQPELRTRRRAYLWCKEFLPGAWRGLREDQFHISVIRGGLSNMLFQCSLPDTLATVGDEPRKVLLRLYGAILKMRSCNKEGSEQAQKDSEFQGAEAMVLESVMFAILAERSLGPKLFGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMARFHGMKMPFNKEPKWLFGTMEKYLNQVLRIRFTGESKVKQLHRFLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLDGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYNYEKYPFFRANILKYPTRKQQLHFISNYLAAFQNEFENLSNEEKSVIEEEMLLEVNRFALASHFFWGLWSIVQAKISSIEFGYMEYAQARFDAYFDQKRKLGV", "length": 570, "header": "tr|F1MI39-1|F1MI39_BOVIN Computationally mapped isoform of Ethanolamine kinase OS=Bos taurus OX=9913 GN=CHKA PE=3 SV=2 CANONICAL=A0A3Q1LRY5-1" }, "locus": { "chromosome": "29", "start_pos": 45639699, "end_pos": 45580838, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013607.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013607.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013607.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013607.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 20, "start_aa": "Thr", "end_pos": 20, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr20", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1483191", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483191", "resource": "Reactome", "description": "Synthesis of PC" }, { "id": "R-BTA-1483213", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483213", "resource": "Reactome", "description": "Synthesis of PE" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P2G3-1", "protein_name": "Ethanolamine kinase", "gene_name": "CHKA", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKTKFCNGEADPSPLGLLLGCDPGSGGGGVVLPAAGQPPSPLSHGGPEGKDPAAAGRGGGAVSPTSPVPPPPEEEPPLDPRTRRRAYLWCKEFLPGAWRGLREEQLLISPIRGGLSNMLFQCSLPDSIETVADEPRKVLLRLYGAILQMRSCNKGESEQSQKENDLQGAEAMVLESVMFAILAERALGPKLYGIFPQGRLEEFIPSRKLSTEELSLPDISAEIAEKMAIFHGMKMPFNKEPKWLFGTMEKYLNQVLRIKFTRESKTRKLNKLLSYNLPQEMKNLRAMLEATSSPVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYTYEKYPFFKASVLKYPSKKQQLHFISSYLSAFQDGFENLSNEEKSKLEEDMLVEVNRFALASHFFWGLWSIIQAKISSIEFGYLEYALSRFDVYFDQKKKLQV", "length": 452 }, "evidence": [ { "id": "A0A3Q1LRY5", "url": "https://omabrowser.org/oma/group/A0A3Q1LRY5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O54804-1", "protein_name": "Choline kinase alpha", "gene_name": "Chka", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTKFCTGGEAEPSPLGLLLSCGGNAAPTPGVGQQRDAAGELESKQLGGRTQPLALPPPPPPPLPLPPPPSPPLADEQPEPRTRRRAYLWCKEFLPGAWRGLREDQFHISVIRGGLSNMLFQCSLPDSIASVGDEPRKVLLRLYGAILKMRSCNKEGSEQAQNENEFQGAEAMVLESVMFAILAERSLGPKLFGIFPQGRLEQFIPSRRLDTEELRLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLNQVLRLKFSREARVQQLHKILSYNLPLELENLRSLLQYTRSPVVFCHNDCQEGNILLLEGQENSERRKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYTYEKYPFFRANIQKYPSRKQQLHFISSYLTTFQNDFESLSSEEQFATKEDMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMEYAQARFEAYFDQKRKLGV", "length": 453 }, "evidence": [ { "id": "A0A3Q1LRY5", "url": "https://omabrowser.org/oma/group/A0A3Q1LRY5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P35790-1", "protein_name": "Choline kinase alpha", "gene_name": "CHKA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV", "length": 457 }, "evidence": [ { "id": "A0A3Q1LRY5", "url": "https://omabrowser.org/oma/group/A0A3Q1LRY5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q01134-1", "protein_name": "Choline kinase alpha", "gene_name": "Chka", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKTKFCTGGEAEPSPLGLLLSCGGSAAPTPGVGQQRDAAGELESKQLGGRSQPLALPPPPPPPLPLPPPPSPPLADEQPEPRTRRRAYLWCKEFLPGAWRGLREDQFHISVIRGGLSNMLFQCSLPDSIASVGDEPRKVLLRLYGAILKMRSCNKEGSEQAQNENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELCLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLNQVLRLKFSREARVQQLHKFLSYNLPLELENLRSLLQYTRSPVVFCHNDCQEGNILLLEGQENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYTYEKYPFFRANIQKYPTRKQQLHFISSYLTTFQNDFESLSSEEQSATKEDMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMEYAQARFDAYFDQKRKLGV", "length": 453 }, "evidence": [ { "id": "A0A3Q1LRY5", "url": "https://omabrowser.org/oma/group/A0A3Q1LRY5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q1LWF1-1", "protein_name": "Ethanolamine kinase", "gene_name": "chka", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKTKFINGVSSSPSMSLGLLVNESVLEVQPDSVNDCKDIIRPDEPDQQTKHKAYLWCREFLHGAWKSIDEEDFQISIIRGGLSNKLFLCALPEMQASLGDEPRNVLLRLYGEILQMSCNKGDSRQSNTENHFQGADAMVLESVMFAILAERELGPKLYGIFPQGRLEQFVPSRKLTTDELSVPGINAEIAEKIARFHGMRMPFNKEPKWLFGTMEKYMDQVLQLTFTREPHLRNFSRILSYNLPQEMDNLKCLLESTPSPVVFCHNDLQEGNILLLNGRENTDRQRLMLIDFEYSSYNYRGFDIGNFFCEWTYDYTYDKFPFFTNNTKNYPTKAQQMHIFHSYLLESDAGFKHLSEEDQMKLKEDMLVEVNRFALASHFFWGLWSMIQAKISTIEFGYMEYAMARFDAYFELKRKLGV", "length": 418 }, "evidence": [ { "id": "A0A3Q1LRY5", "url": "https://omabrowser.org/oma/group/A0A3Q1LRY5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q869T9-1", "protein_name": "Probable ethanolamine kinase A", "gene_name": "etnkA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MMAKTKGSYEVFHYTVTKDKVNKGLCDIARYFVPEYRNSKDEDLTIQKLNGGITNVLYLVEDKNIEQKYRYLPVVIRLYGYKSEEIIDRKNELIIQTEADQNGLGAKFYGLFDNGCIYGFIKGEPLAYEDISKPTMQTCIAKEIAQWHSIEMPTRKNPSLWPTIKKWAALAPDVYPVPEKNEYYQSINVKKMIEEGKMLEQRLAQLNSPIVFCHNDLLSGNIIYDPSQNCASFIDFEYANYNFRGLELGNHFNEYAGFGPDYSLYPNKESQIHFLTDYHRSLFKTEPTQDELEKLYIESNQFSLASHLYWGFWAIVQAMNSQIDFDYLEYGKARFDRYYETRDQFLNLN", "length": 349 }, "evidence": [ { "id": "A0A3Q1LRY5", "url": "https://omabrowser.org/oma/group/A0A3Q1LRY5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "CDP-choline pathway", "id": "GO:0006657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006657", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRY5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ], "pmid": "" }, { "name": "phosphatidylethanolamine biosynthetic process", "id": "GO:0006646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006646", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRY5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRY5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRY5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ], "pmid": "" }, { "name": "choline kinase activity", "id": "GO:0004103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004103", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRY5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ], "pmid": "" }, { "name": "ethanolamine kinase activity", "id": "GO:0004305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004305", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRY5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRY5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRY5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 505, "end_pos": 507, "annotation": "n_glycosylation_sequon" }, { "start_pos": 523, "end_pos": 525, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12837", "name": "", "equation": "choline + ATP = phosphocholine + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LRY5-1", "G3X782-1" ], "evidence": [ { "id": "12837", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12837" } ] }, { "id": "13069", "name": "", "equation": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LRY5-1", "G3X782-1" ], "evidence": [ { "id": "13069", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13069" } ] }, { "id": "R-BTA-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-264618" ], "output_participant_list": [ "R-ALL-1524071" ], "enzyme_list": [ "G3X782-1", "A0A3Q1LRY5-1" ], "evidence": [ { "id": "R-BTA-1483004", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483004" } ] }, { "id": "R-BTA-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-1498751" ], "output_participant_list": [], "enzyme_list": [ "G3X782-1", "F1N378-1", "A0A3Q1LRY5-1", "F1MRD9-1" ], "evidence": [ { "id": "R-BTA-1483222", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483222" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1498751", "participant_name": "ETA [cytosol]", "crossref": [ { "id": "57603", "database": "ChEBI", "url": "" }, { "id": "ZINC000008214617", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-1524071", "participant_name": "PCho [cytosol]", "crossref": [ { "id": "36700", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-264618", "participant_name": "Cho [cytosol]", "crossref": [ { "id": "15354", "database": "ChEBI", "url": "" }, { "id": "4551", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000003079337", "database": "ZINC", "url": "" }, { "id": "HMDB0000097", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LRY5", "gene_name": "CHKA", "activity": [ { "ec_number": "2.7.1.32", "activity": "choline + ATP = phosphocholine + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ] }, { "ec_number": "2.7.1.82", "activity": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ] } ] }, { "uniprot_ac": "F1MRD9", "gene_name": "ETNK2", "activity": [ { "ec_number": "2.7.1.82", "activity": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+).", "evidence": [ { "id": "F1MRD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRD9" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "F1MRD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRD9" } ] } ] }, { "uniprot_ac": "F1N378", "gene_name": "ETNK1", "activity": [ { "ec_number": "2.7.1.82", "activity": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+).", "evidence": [ { "id": "F1N378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N378" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "F1N378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N378" } ] } ] }, { "uniprot_ac": "G3X782", "gene_name": "CHKB", "activity": [ { "ec_number": "2.7.1.32", "activity": "choline + ATP = phosphocholine + ADP + H(+).", 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"end_pos": 35447674, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006974", "url": "https://www.ensembl.org/id/ENSBTAG00000006974" } ] } } ], "crossref": [ { "id": "ENSBTAG00000006974", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006974", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13248", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13248", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "528261", "url": "https://www.ncbi.nlm.nih.gov/gene/528261", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FINDKSH", "url": "https://omabrowser.org/oma/group/FINDKSH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LRZ5", "url": "https://www.orthodb.org/?gene=A0A3Q1LRZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MIJ3", "url": "https://www.orthodb.org/?gene=A0A3Q1MIJ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MTD1", "url": "https://www.orthodb.org/?gene=A0A3Q1MTD1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NCT3", "url": "https://www.orthodb.org/?gene=A0A3Q1NCT3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MKZ7", "url": "https://www.orthodb.org/?gene=F1MKZ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12752", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12752", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12752:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12752:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25541", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25541", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059731080", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731080", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRZ5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTD1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTD1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NCT3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NCT3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5C0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5C0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGN9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T221", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T221", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T221-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T221-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TID0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TID0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TID0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TID0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NPA3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NPA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NPA3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NPA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKZ7", "url": "https://www.uniprot.org/uniprotkb/F1MKZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKZ7-1", "url": "https://www.uniprot.org/uniprotkb/F1MKZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDRPGAQPGPAQAEPARPPPAPPPPPPPPPLPAAAPRAANMAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRYTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVSGQFSPENSEFILQEEEPNPHMSKQERNQRPSSMVSETSTAGTTSTVEAKPGPKIIKSSNKVHSFGKRDQAIRRNPSVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEVVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDTEKVERQAVPQANHTESCRECGRVGPGHARDCPHRSHEDSFGFERREQEEDRYRSRDPLEGKRDRNKARSPYSQVEEDALFVDLPSGPRGQQAQPQRAERNGVLPVTSGPGEQNGTAGYQRAFPSRTNPEKHSQRKSSLAQVEQWAKAQKGDGRSLPPEQTLPRQGPSQHLSFPENYQTLPRSSRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICAGSPEFAEQGRSRSMLEVPRSISVPPSPSDLPPPGPPRAFPPRRPHTPAERVTVKPPDQRMSVDISLGGSPRKAWGPTTKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDIDVKLSVFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQRLLQEDLVHIRAELSRESTEMENAWNEYLKLERDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVIAGLSANKENFRILVESVKNPERKTVPLLPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKTKPRVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDSRVELRSYVSEPELATFSGDTAPSSLGLVGSESRYQTLPGRGLSGSMSRLQQSSTIAPYVTLRRGLDAESSKMTYPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLPSSRYLSQPLPGDLGSWKREQDFDLQLLERAVQGDRKDKEENGWLKVQAMPVTELDLEPQDYDVDISRELSKPEKVSIPERYVELDPEEPPSLEELQARYRKAEKIRNILTRSSMCNLQPTASQDRNSVADLDSQLQEQERIINISYALASEASQRSKQVAAQQLALLPPKAPLSSRTVPPYPPLSNGLHYTFV", "length": 1333, "header": "tr|A0A3Q1LRZ5-1|A0A3Q1LRZ5_BOVIN Isoform 1 of Pleckstrin homology domain-containing family A member 7 OS=Bos taurus OX=9913 GN=PLEKHA7 PE=4 SV=2 CANONICAL=A0A3Q1LRZ5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRZ5/entry", "sequence": { "sequence": "MDRPGAQPGPAQAEPARPPPAPPPPPPPPPLPAAAPRAANMAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRYTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVSGQFSPENSEFILQEEEPNPHMSKQERNQRPSSMVSETSTAGTTSTVEAKPGPKIIKSSNKVHSFGKRDQAIRRNPSVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEVVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDTEKVERQAVPQANHTESCRECGRVGPGHARDCPHRSHEDSFGFERREQEEDRYRSRDPLEGKRDRNKARSPYSQVEEDALFVDLPSGPRGQQAQPQRAERNGVLPVTSGPGEQNGTAGYQRAFPSRTNPEKHSQRKSSLAQVEQWAKAQKGDGRSLPPEQTLPRQGPSQHLSFPENYQTLPRSSRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICAGSPEFAEQGRSRSMLEVPRSISVPPSPSDLPPPGPPRAFPPRRPHTPAERVTVKPPDQRMSVDISLGGSPRKAWGPTTKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDIDVKLSVFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQRLLQEDLVHIRAELSRESTEMENAWNEYLKLERDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVIAGLSANKENFRILVESVKNPERKTVPLLPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKTKPRVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDSRVELRSYVSEPELATFSGDTAPSSLGLVGSESRYQTLPGRGLSGSMSRLQQSSTIAPYVTLRRGLDAESSKMTYPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLPSSRYLSQPLPGDLGSWKREQDFDLQLLERAVQGDRKDKEENGWLKVQAMPVTELDLEPQDYDVDISRELSKPEKVSIPERYVELDPEEPPSLEELQARYRKAEKIRNILTRSSMCNLQPTASQDRNSVADLDSQLQEQERIINISYALASEASQRSKQVAAQQLALLPPKAPLSSRTVPPYPPLSNGLHYTFV", "length": 1333, "header": "tr|A0A3Q1LRZ5-1|A0A3Q1LRZ5_BOVIN Isoform 1 of Pleckstrin homology domain-containing family A member 7 OS=Bos taurus OX=9913 GN=PLEKHA7 PE=4 SV=2 CANONICAL=A0A3Q1LRZ5-1" }, "locus": { "chromosome": "15", "start_pos": 35673861, "end_pos": 35447873, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070183.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070183.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057847.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057847.2" } ] } }, { "isoform_ac": "A0A3Q1MIJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIJ3/entry", "sequence": { "sequence": "MVCIPGCAIAASWVEGSATTSNQVFIPGLAESTRHNQQTTAFRHPVSGQFSPENSEFILQEEEPNPHMSKQERNQRPSSMVSETSTAGTTSTVEAKPGPKIIKSSNKVHSFGKRDQAIRRNPSVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEVVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDTEKVERQAVPQANHTESCRECGRVGPGHARDCPHRSHEDSFGFERREQEEDRYRSRDPLEGKRDRNKARSPYSQVEEDALFVDLPSGPRGQQAQPQRAERNGVLPVTSGPGEQNGTAGYQRAFPSRTNPEKHSQRKSSLAQVEQWAKAQKGDGRSLPPEQTLPRQGPSQHLSFPENYQTLPRSSRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICAGSPEFAEQGRSRSMLEVPRSISVPPSPSDLPPPGPPRAFPPRRPHTPAERVTVKPPDQRMSVDISLGGSPRKAWGPTTKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDIDVKLSVFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQRLLQEDLVHIRAELSRESTEMENAWNEYLKLERDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVIAGLSANKENFRILVESVKNPERKTVPLLPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKTKPRVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDSRVELRSYVSEPELATFSGDTAPSSLGLVGSESRYQTLPGRGLSGSMSRLQQSSTIAPYVTLRRGLDAESSKMTYPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLPSSRYLSQPLPGDLGSWKREQDFDLQLLERAVQGDRKDKEENGWLKVQAMPVTELDLEPQDYDVDISRELSKPEKVSIPERYVELDPEEPPSLEELQARYRKAEKIRNILTRSSMCNLQPTASQDRNSVADLDSQLQEQERIINISYALASEASQRSKQVAAQAVTDP", "length": 1227, "header": "tr|A0A3Q1MIJ3-1|A0A3Q1LRZ5_BOVIN Computationally mapped isoform of Pleckstrin homology domain-containing family A member 7 OS=Bos taurus OX=9913 GN=PLEKHA7 PE=4 SV=2 CANONICAL=A0A3Q1LRZ5-1" }, "locus": { "chromosome": "15", "start_pos": 35675228, "end_pos": 35533602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074757.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074757.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071102.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071102.2" } ] } }, { "isoform_ac": "A0A3Q1MTD1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTD1/entry", "sequence": { "sequence": "MHPSSGSKSRSHCLRMAYDPSSSCRFVTRVQTSISHNQQTTAFRHPVSGQFSPENSEFILQEEEPNPHMSKQERNQRPSSMVSETSTAGTTSTVEAKPGPKIIKSSNKVHSFGKRDQAIRRNPSVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEVVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDTEKVERQAVPQANHTESCRECGRVGPGHARDCPHRSHEDSFGFERREQEEDRYRSRDPLEGKRDRNKARSPYSQVEEDALFVDLPSGPRGQQAQPQRAERNGVLPVTSGPGEQNGTAGYQRAFPSRTNPEKHSQRKSSLAQVEQWAKAQKGDGRSLPPEQTLPRQGPSQHLSFPENYQTLPRSSRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICAGSPEFAEQGRSRSMLEVPRSISVPPSPSDLPPPGPPRAFPPRRPHTPAERVTVKPPDQRMSVDISLGGSPRKAWGPTTKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDIDVKLSVFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQRLLQEDLVHIRAELSRESTEMENAWNEYLKLERDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVIAGLSANKENFRILVESVKNPERKTVPLLPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKTKPRVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDSRVELRSYVSEPELATFSGDTAPSSLGLVGSESRYQTLPGRGLSGSMSRLQQSSTIAPYVTLRRGLDAESSKMTYPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLPSSRYLSQPLPGDLGSWKREQDFDLQLLERAVQGDRKDKEENGWLKVQAMPVTELDLEPQDYDVDISRELSKPEKVSIPERYVELDPEEPPSLEELQARYRKAEKIRNILTRSSMCNLQPTASQDRNSVADLDSQLQEQERIINISYALASEASQRSKQVAAQQLALLPPKAPLSSRTVPPYPPLSNGLHYTFV", "length": 1254, "header": "tr|A0A3Q1MTD1-1|A0A3Q1LRZ5_BOVIN Computationally mapped isoform of Pleckstrin homology domain-containing family A member 7 OS=Bos taurus OX=9913 GN=PLEKHA7 PE=4 SV=2 CANONICAL=A0A3Q1LRZ5-1" }, "locus": { "chromosome": "15", "start_pos": 35673861, "end_pos": 35580577, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075249.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075249.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073544.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073544.2" } ] } }, { "isoform_ac": "A0A3Q1NCT3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCT3/entry", "sequence": { "sequence": "MPIHLYPITEVKTFCSREKNFKKIDFSGHNQQTTAFRHPVSGQFSPENSEFILQEEEPNPHMSKQERNQRPSSMVSETSTAGTTSTVEAKPGPKIIKSSNKVHSFGKRDQAIRRNPSVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEVVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDTEKVERQAVPQANHTESCRECGRVGPGHARDCPHRSHEDSFGFERREQEEDRYRSRDPLEGKRDRNKARSPYSQVEEDALFVDLPSGPRGQQAQPQRAERNGVLPVTSGPGEQNGTAGYQRAFPSRTNPEKHSQRKSSLAQVEQWAKAQKGDGRSLPPEQTLPRQGPSQHLSFPENYQTLPRSSRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICAGSPEFAEQGRSRSMLEVPRSISVPPSPSDLPPPGPPRAFPPRRPHTPAERVTVKPPDQRMSVDISLGGSPRKAWGPTTKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDIDVKLSVFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQRLLQEDLVHIRAELSRESTEMENAWNEYLKLERDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVIAGLSANKENFRILVESVKNPERKTVPLLPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKTKPRVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDSRVELRSYVSEPELATFSGDTAPSSLGLVGSESRYQTLPGRGLSGSMSRLQQSSTIAPYVTLRRGLDAESSKMTYPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLPSSRYLSQPLPGDLGSWKREQDFDLQLLERAVQGDRKDKEENGWLKVQAMPVTELDLEPQDYDVDISRELSKPEKVSIPERYVELDPEEPPSLEELQARYRKAEKIRNILTRSSMCNLQPTASQDRNSVADLDSQLQEQERIINISYALASEASQRSKQVAAQQLALLPPKAPLSSRTVPPYPPLSNGLHYTFV", "length": 1247, "header": "tr|A0A3Q1NCT3-1|A0A3Q1LRZ5_BOVIN Computationally mapped isoform of Pleckstrin homology domain-containing family A member 7 OS=Bos taurus OX=9913 GN=PLEKHA7 PE=4 SV=3 CANONICAL=A0A3Q1LRZ5-1" }, "locus": { "chromosome": "15", "start_pos": 35673861, "end_pos": 35586641, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068968.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068968.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069232.3", "url": "https://www.ensembl.org/id/ENSBTAP00000069232.3" } ] } }, { "isoform_ac": "A0AAA9S5C0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5C0/entry", "sequence": { "sequence": "MDRPGAQPGPAQAEPARPPPAPPPPPPPPPLPAAAPRAANMAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRYTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVSGQFSPENSEFILQEEEPNPHMSKQERNQRPSSMVSETSTAGTTSTVEAKPGPKIIKSSNKVHSFGKRDQAIRRNPSVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEVVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDTEKVERQAVPQANHTESCRECGRVGPGHARDCPHRSHEDSFGFERREQEEDRYRSRDPLEGKRDRNKARSPYSQVEEDALFVDLPSGPRGQQAQPQRAERNGVLPVTSGPGEQNGTAGYQRAFPSRTNPEKHSQRKSSLAQVEQWAKAQKGDGRSLPPEQTLPRQGPSQHLSFPENYQTLPRSSRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICAGSPEFAEQGRSRSMLEVPRSISVPPSPSDLPPPGPPRAFPPRRPHTPAERVTVKPPDQRMSVDISLGGSPRKAWGPTTKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDIDVKLSVFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQRLLQEDLVHIRAELSRESTEMENAWNEYLKLERDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVIAGLSANKENFRILVESVKNPERKTVPLLPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKTKPRVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDSRVELRSYVSEPELATFSGDTAPSSLGLVGSESRYQTLPGRGLSGSMSRLQQSSTIAPYVTLRRGLDAESSKMTYPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLPSSRYLSQPLPGDLGSWKREQDFDLQLLERAVQGDRKDKEENGWLKVQAMPVTELDLEPQDYDVDISRELSKPEKVSIPERYVELDPEEPPSLEELQARYRKAEKIRNILTRSSMCNLQPTASQDRNSVADLDSQLQEQERIINISYALASEASQRSKQVAAQAVTDP", "length": 1307, "header": "tr|A0AAA9S5C0-1|A0A3Q1LRZ5_BOVIN Computationally mapped isoform of Pleckstrin homology domain-containing family A member 7 OS=Bos taurus OX=9913 GN=PLEKHA7 PE=4 SV=2 CANONICAL=A0A3Q1LRZ5-1" }, "locus": { "chromosome": "15", "start_pos": 35675228, "end_pos": 35447873, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100370.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100370.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077358.2", "url": "https://www.ensembl.org/id/ENSBTAP00000077358.2" } ] } }, { "isoform_ac": "A0AAA9SGN9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGN9/entry", "sequence": { "sequence": "MEPRRCPAGDACPAALGGWRGPPRGACSHNQQTTAFRHPVSGQFSPENSEFILQEEEPNPHMSKQERNQRPSSMVSETSTAGTTSTVEAKPGPKIIKSSNKVHSFGKRDQAIRRNPSVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEVVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDTEKVERQAVPQANHTESCRECGRVGPGHARDCPHRSHEDSFGFERREQEEDRYRSRDPLEGKRDRNKARSPYSQVEEDALFVDLPSGPRGQQAQPQRAERNGVLPVTSGPGEQNGTAGYQRAFPSRTNPEKHSQRKSSLAQVEQWAKAQKGDGRSLPPEQTLPRQGPSQHLSFPENYQTLPRSSRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICAGSPEFAEQGRSRSMLEVPRSISVPPSPSDLPPPGPPRAFPPRRPHTPAERVTVKPPDQRMSVDISLGGSPRKAWGPTTKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDIDVKLSVFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQRLLQEDLVHIRAELSRESTEMENAWNEYLKLERDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVIAGLSANKENFRILVESVKNPERKTVPLLPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKTKPRVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDSRVELRSYVSEPELATFSGDTAPSSLGLVGSESRYQTLPGRGLSGSMSRLQQSSTIAPYVTLRRGLDAESSKMTYPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLPSSRYLSQPLPGDLGSVC", "length": 1071, "header": "tr|A0AAA9SGN9-1|A0A3Q1LRZ5_BOVIN Computationally mapped isoform of Pleckstrin homology domain-containing family A member 7 OS=Bos taurus OX=9913 GN=PLEKHA7 PE=4 SV=2 CANONICAL=A0A3Q1LRZ5-1" }, "locus": { "chromosome": "15", "start_pos": 35665580, "end_pos": 35534245, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120372.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120372.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081663.2", "url": "https://www.ensembl.org/id/ENSBTAP00000081663.2" } ] } }, { "isoform_ac": "A0AAA9T221-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T221/entry", "sequence": { "sequence": "MLPWRKLEGLWLLLSQLGGRSLHRVAADNTSHNQQTTAFRHPVSGQFSPENSEFILQEEEPNPHMSKQERNQRPSSMVSETSTAGTTSTVEAKPGPKIIKSSNKVHSFGKRDQAIRRNPSVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEVVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDTEKVERQAVPQANHTESCRECGRVGPGHARDCPHRSHEDSFGFERREQEEDRYRSRDPLEGKRDRNKARSPYSQVEEDALFVDLPSGPRGQQAQPQRAERNGVLPVTSGPGEQNGTAGYQRAFPSRTNPEKHSQRKSSLAQVEQWAKAQKGDGRSLPPEQTLPRQGPSQHLSFPENYQTLPRSSRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICAGSPEFAEQGRSRSMLEVPRSISVPPSPSDLPPPGPPRAFPPRRPHTPAERVTVKPPDQRMSVDISLGGSPRKAWGPTTKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDIDVKLSVFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQRLLQEDLVHIRAELSRESTEMENAWNEYLKLERDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVIAGLSANKENFRILVESVKNPERKTVPLLPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKTKPRVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDSRVELRSYVSEPELATFSGDTAPSSLGLVGSESRYQTLPGRGLSGSMSRLQQSSTIAPYVTLRRGLDAESSKMTYPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLPSSRYLSQPLPGDLGSVC", "length": 1074, "header": "tr|A0AAA9T221-1|A0A3Q1LRZ5_BOVIN Computationally mapped isoform of Pleckstrin homology domain-containing family A member 7 OS=Bos taurus OX=9913 GN=PLEKHA7 PE=4 SV=1 CANONICAL=A0A3Q1LRZ5-1" }, "locus": { "chromosome": "15", "start_pos": 35665580, "end_pos": 35546636, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134083.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134083.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092844.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092844.1" } ] } }, { "isoform_ac": "A0AAA9TID0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TID0/entry", "sequence": { "sequence": "MEPRRCPAGDACPAALGGWRGPPRGACSHNQQTTAFRHPVSGQFSPENSEFILQEEEPNPHMSKQERNQRPSSMVSETSTAGTTSTVEAKPGPKIIKSSNKVHSFGKRDQAIRRNPSVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEVVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDTEKVERQAVPQANHTESCRECGRVGPGHARDCPHRSHEDSFGFERREQEEDRYRSRDPLEGKRDRNKARSPYSQVEEDALFVDLPSGPRGQQAQPQRAERNGVLPVTSGPGEQNGTAGYQRAFPSRTNPEKHSQRKSSLAQVEQWAKAQKGDGRSLPPEQTLPRQGPSQHLSFPENYQTLPRSSRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICAGSPEFAEQGRSRSMLEVPRSISVPPSPSDLPPPGPPRAFPPRRPHTPAERVTVKPPDQRMSVDISLGGSPRKAWGPTTKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDIDVKLSVFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQRLLQEDLVHIRAELSRESTEMENAWNEYLKLERDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVIAGLSANKENFRILVESVKNPERKTVPLLPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKTKPRVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDSRVELRSYVSEPELATFSGDTAPSSLGLVGSESRYQTLPGRGLSGSMSRLQQSSTIAPYVTLRRGLDAESSKMTYPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLPSSRYLSQPLPGDLGSWKREQDFDLQLLERAVQGDRKDKEENGWLKVQAMPVTELDLEPQDYDVDISREGHGGCCPEWDRLGFSVAQRMGEQQLEVVRGVQTL", "length": 1156, "header": "tr|A0AAA9TID0-1|A0A3Q1LRZ5_BOVIN Computationally mapped isoform of Pleckstrin homology domain-containing family A member 7 OS=Bos taurus OX=9913 GN=PLEKHA7 PE=4 SV=1 CANONICAL=A0A3Q1LRZ5-1" }, "locus": { "chromosome": "15", "start_pos": 35668795, "end_pos": 35534245, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116948.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116948.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098230.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098230.1" } ] } }, { "isoform_ac": "A0ABI0NPA3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NPA3/entry", "sequence": { "sequence": "MLGLCRGRPNPHMSKQERNQRPSSMVSETSTAGTTSTVEAKPGPKIIKSSNKVHSFGKRDQAIRRNPSVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEVVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDTEKVERQAVPQANHTESCRECGRVGPGHARDCPHRSHEDSFGFERREQEEDRYRSRDPLEGKRDRNKARSPYSQVEEDALFVDLPSGPRGQQAQPQRAERNGVLPVTSGPGEQNGTAGYQRAFPSRTNPEKHSQRKSSLAQVEQWAKAQKGDGRSLPPEQTLPRQGPSQHLSFPENYQTLPRSSRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICAGSPEFAEQGRSRSMLEVPRSISVPPSPSDLPPPGPPRAFPPRRPHTPAERVTVKPPDQRMSVDISLGGSPRKAWGPTTKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDIDVKLSVFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQRLLQEDLVHIRAELSRESTEMENAWNEYLKLERDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVIAGLSANKENFRILVESVKNPERKTVPLLPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKTKPRVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDSRVELRSYVSEPELATFSGDTAPSSLGLVGSESRYQTLPGRGLSGSMSRLQQSSTIAPYVTLRRGLDAESSKMTYPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLPSSRYLSQPLPGDLGSVC", "length": 1022, "header": "tr|A0ABI0NPA3-1|A0ABI0NPA3_BOVIN Computationally mapped isoform of Pleckstrin homology domain containing A7 OS=Bos taurus OX=9913 GN=PLEKHA7 PE=4 SV=1 CANONICAL=A0A3Q1LRZ5-1" }, "locus": { "chromosome": "15", "start_pos": 35665580, "end_pos": 35599693, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146827.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146827.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107688.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107688.1" } ] } }, { "isoform_ac": "F1MKZ7-1", "url": "https://www.uniprot.org/uniprotkb/F1MKZ7/entry", "sequence": { "sequence": "MSKQERNQRPSSMVSETSTAGTTSTVEAKPGPKIIKSSNKVHSFGKRDQAIRRNPSVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEVVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDTEKVERQAVPQANHTESCRECGRVGPGHARDCPHRSHEDSFGFERREQEEDRYRSRDPLEGKRDRNKARSPYSQVEEDALFVDLPSGPRGQQAQPQRAERNGVLPVTSGPGEQNGTAGYQRAFPSRTNPEKHSQRKSSLAQVEQWAKAQKGDGRSLPPEQTLPRQGPSQHLSFPENYQTLPRSSRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICAGSPEFAEQGRSRSMLEVPRSISVPPSPSDLPPPGPPRAFPPRRPHTPAERVTVKPPDQRMSVDISLGGSPRKAWGPTTKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDIDVKLSVFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQRLLQEDLVHIRAELSRESTEMENAWNEYLKLERDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVIAGLSANKENFRILVESVKNPERKTVPLLPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKTKPRVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDSRVELRSYVSEPELATFSGDTAPSSLGLVGSESRYQTLPGRGLSGSMSRLQQSSTIAPYVTLRRGLDAESSKMTYPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLPSSRYLSQPLPGDLGSVC", "length": 1010, "header": "tr|F1MKZ7-1|A0A3Q1LRZ5_BOVIN Computationally mapped isoform of Pleckstrin homology domain-containing family A member 7 OS=Bos taurus OX=9913 GN=PLEKHA7 PE=4 SV=5 CANONICAL=A0A3Q1LRZ5-1" }, "locus": { "chromosome": "15", "start_pos": 35665580, "end_pos": 35600530, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034300.7", "url": "https://www.ensembl.org/id/ENSBTAT00000034300.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034197.7", "url": "https://www.ensembl.org/id/ENSBTAP00000034197.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6A1V7-1", "protein_name": "Pleckstrin homology domain containing A7", "gene_name": "Plekha7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPWRCLPRDARPAALGFWGEPLAACSHNQQTTTFRHPVTGQFSSENSEYVLREEPHPHMSKQERNQRPSSMVSETSTAGTTSTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNLNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYSTTTAGSQAEHSGMRTYYFSADTLEDMNAWVRAMNQAAQVLSRSSLKRDKVERQAMPQANHTDACQECGHVGPGHSRDCPRRGYEDAIVFDRREQEEERFRSQRDTLEGRRDRSKARSPYLPAEEDALFVDLPGGPRGQQAQPQRAERNGLPPYGLGEQNGTSGYSRTAPPRANLEKHSQRKTNLAQTEHWAKAQKGDGRSLPLDQTLPRQGPSQPPSFLENYQTLPRNTRYPSGSSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPIGAGSPEFTEQGRSRSLLEVPRSISVPPSPSDIPPPGPPRPFPPRRPHTPAERVTVKPPDQRRSVDISLGGSPRKARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSLEELSLLLTRLQRHQSKLASVRNFAVGQLLHHYLTFPACQADDTYLQLKKDLEYLDLKIKNNEPLINVLYKVLKKSARGCRPGRSMTGRDLLKDRSLKPMKIAESDTDVKLSIFCEQDRILQDLEDKIRALKENKDQLESVLEVLHRQTEQYRDQPQHLEKITCQQRLLQEDLVHIRAELCRESTEMENAWNEYLKLEKDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVMAGLSVNKENYRVLVGSVKNPERKTVPLFPHPSVPSLSPTESKPALQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVVSPLQSPTKATPQAEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDLKVELRSYVSEPELASFSGDVPRPSLGLVGSESRYQTLPGRGLSGSTSRLQQSSTIAPYVTLRRGLNAENSSVTFSRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGERTGLLSARYLSQPLPGDLGSWKREQEFDLQLLERAAQGDRKDKEEGWLKVQATPVMELDLEPQDYDLDINRELSKPEKVSIPERYVEVDPEEPPSVEELQARYQKAEKIRNILARSSMCNLQPPGQDRNSLADLDTQMQEQERIINISYALASEASQRSKQVAVQPLALLPPKAPLSSRTVPPYPPLSNGLHYTFV", "length": 1311 }, "evidence": [ { "id": "A0A3Q1LRZ5", "url": "https://omabrowser.org/oma/group/A0A3Q1LRZ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3UIL6-1", "protein_name": "Pleckstrin homology domain-containing family A member 7", "gene_name": "Plekha7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASFFIDHNQQTTTFRHPVTGQFSSENSEYVLREEPHPHMSKPERNQRPSSMVSETSTAGTTSTLEAKPGPKIVKSSSKVHSFGKRDQAIRRNLNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYSTTTAGSQMEHSGMRTYYFSADTLEDMNAWVRAMNQAAQVLSRSSLRRDVDKVERQAMPQANHTDACQECGHVGPGHSRDCPRRGYEDSYGFNRREQEEERFRAQRDPLEGRRDRSKARSPYLPAEEDALFVDLPGGPRGQQAQPQRAEKNGVPPYGLGEQNGTNGYQRTAPPRANPEKHSQRKTGLAQAEHWTKAQKGDGRSLPLDQTLPRQGPSQPLSFPENYQSLPKSTRHLSGSSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPIGAGSPEFTEQGRSRSLLEVPRSISVPPSPSDIPPPGPPRPFPPRRPHTPAERVTVKPPEQRRSVDISLGGSPRKARGHAAKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPMKIAESDIDVKLSIFCEQDRILQDLEDKIRALKENKDQLESVLEVLHRQTEQYRDQPQHLEKITCQQRLLQEDLVHIRAELCRESTEMENAWNEYLKLEKDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVMAGLSANKENYRVLVGSVKNPERKTVPLFPHPSVPSLSPTESKPALQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVMSPLQSPTKAKPQAEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDREQGQCVNGDLKVELRSYVSEPELASLSGDVPQPSLSLVGSESRYQTLPGRGLSGSTSRLQQSSTIAPYVTLRRGLNAENSSATFSRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLSQGEKTGLLSARYLSQPLPGDLGSVC", "length": 1118 }, "evidence": [ { "id": "A0A3Q1LRZ5", "url": "https://omabrowser.org/oma/group/A0A3Q1LRZ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6IQ23-1", "protein_name": "Pleckstrin homology domain-containing family A member 7", "gene_name": "PLEKHA7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAATVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQFSPENSEFILQEEPNPHMSKQDRNQRPSSMVSETSTAGTASTLEAKPGPKIIKSSSKVHSFGKRDQAIRRNPNVPVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVERQAVPQANHTESCHECGRVGPGHTRDCPHRGHDDIVNFERQEQEGEQYRSQRDPLEGKRDRSKARSPYSPAEEDALFMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHWARAQKGDSRSLPLDQTLPRQGPGQSLSFPENYQTLPKSTRHPSGGSSPPPRNLPSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICLGSPEFTDQGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRRPHTPAERVTVKPPDQRRSVDISLGDSPRRARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSADDTYLQLKKDLEYLDLKMTGRDLLKDRSLKPVKIAESDTDVKLSIFCEQDRVLQDLEDKIRALKENKDQLESVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRESTEMENAWNEYLKLENDVEQLKQTLQEQHRRAFFFQEKSQIQKDLWRIEDVTAGLSANKENFRILVESVKNPERKTVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTYVPYRPHPPQLRKVTSPLQSPTKAKPKVEDEAPPRPPLPELYSPEDQPPAVPPLPREATIIRHTSVRGLKRQSDERKRDRELGQCVNGDSRVELRSYVSEPELATLSGDMAQPSLGLVGPESRYQTLPGRGLSGSTSRLQQSSTIAPYVTLRRGLNAESSKATFPRPKSALERLYSGDHQRGKMSAEEQLERMKRHQKALVRERKRTLGQGERTGLPSSRYLSRPLPGDLGSVC", 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"categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052242", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052242", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MRLGCNQ", "url": "https://omabrowser.org/oma/group/MRLGCNQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR43561", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43561", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43561:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43561:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00725", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00725", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02737", "url": 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"MAFVTRQFVRSMSSSSSASASAKKILVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILEKSRKGIEESLRKVAKKKFAENPKGTDEFVAKTLSSISTSTDAASVVHSTDLVVAIVENLQMKNELFKRLDKFAAEHTIFASNTSSLQITSLANSTTRQDRFAGLHFFNPVPLMKLVEVIKTPMTSQKTFESLLDFSRALGKHPVACKDTPGFIVNRLLVPYLMEAVRLCERGEASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMDSKNPLFQPCPSLNKLVAEKKFGKKSGEGFYKYK", "length": 313, "header": "tr|A0A3Q1LS03-1|A0A3Q1LS03_BOVIN Isoform 1 of Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0A3Q1LS03-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LS03-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03/entry", "sequence": { "sequence": "MAFVTRQFVRSMSSSSSASASAKKILVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILEKSRKGIEESLRKVAKKKFAENPKGTDEFVAKTLSSISTSTDAASVVHSTDLVVAIVENLQMKNELFKRLDKFAAEHTIFASNTSSLQITSLANSTTRQDRFAGLHFFNPVPLMKLVEVIKTPMTSQKTFESLLDFSRALGKHPVACKDTPGFIVNRLLVPYLMEAVRLCERGEASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMDSKNPLFQPCPSLNKLVAEKKFGKKSGEGFYKYK", "length": 313, "header": "tr|A0A3Q1LS03-1|A0A3Q1LS03_BOVIN Isoform 1 of Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0A3Q1LS03-1" }, "locus": { "chromosome": "26", "start_pos": 5705889, "end_pos": 5704951, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054475.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054475.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063081.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063081.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-77310", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77310", "resource": "Reactome", "description": "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" }, { "id": "R-BTA-77346", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77346", "resource": "Reactome", "description": "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA" }, { "id": "R-BTA-77348", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77348", "resource": "Reactome", "description": "Beta oxidation of octanoyl-CoA to hexanoyl-CoA" }, { "id": "R-BTA-77350", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77350", "resource": "Reactome", "description": "Beta oxidation of hexanoyl-CoA to butanoyl-CoA" }, { "id": "R-BTA-77352", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77352", "resource": "Reactome", "description": "Beta oxidation of butanoyl-CoA to acetyl-CoA" }, { "id": "R-BTA-9837999", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9837999", "resource": "Reactome", "description": "Mitochondrial protein degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q54VB8-1", "protein_name": "3-hydroxybutyryl-CoA dehydrogenase", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFLRKSIQTLSQRYYSTSNIKSVGVIGGGQMGSGIAQVLAQVAKRNVILVDLNKAVVEKSLININGFLQKSVAKGVITEEDRQSTLKRISFSDDLNSLKNVDFVIEAIVENTEIKCNLFKDLSKICKPEAILASNTSSISITQIASNTNNPQNVIGMHFMNPVPIMKLVEVIPSLQTNDETLKTTMELAAEMNKTTTLSKDMPGFIANRLLMPYINEAVQALHEGLGTREDIDTTMKLGCNMPMGPLTLADFIGLDTCYSIMNILHTQLGDKYKPSPLLKRYVEAGRLGKKVKHGFYTY", "length": 299 }, "evidence": [ { "id": "A0A3Q1LS03", "url": "https://omabrowser.org/oma/group/A0A3Q1LS03/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS03", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS03", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "fatty acid beta-oxidation", "id": "GO:0006635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006635", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS03", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS03", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS03", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "NAD+ binding", "id": "GO:0070403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070403", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS03", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ], "pmid": "" }, { "name": "(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity", "id": "GO:0003857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003857", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS03", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22432", "name": "", "equation": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N338-1", "A0AAA9SND8-1", "O02691-1", "A0A3Q1LS03-1", "A0AAA9RY48-1" ], "evidence": [ { "id": "22432", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22432" } ] }, { "id": "30799", "name": "", "equation": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O02691-1", "A0AAA9RY48-1", "A0A3Q1LS03-1", "F1N338-1" ], "evidence": [ { "id": "30799", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/30799" } ] }, { "id": "31159", "name": "", "equation": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SND8-1", "O02691-1", "A0A3Q1NDR1-1", "A0AAA9RY48-1", "A0A3Q1LS03-1", "F1N338-1" ], "evidence": [ { "id": "31159", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/31159" } ] }, { "id": "31187", "name": "", "equation": "(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SND8-1", "A0A3Q1NDR1-1", "A0A3Q1LS03-1", "F1N338-1" ], "evidence": [ { "id": "31187", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/31187" } ] }, { "id": "R-BTA-77254", "name": "(S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-77252" ], "output_participant_list": [], "enzyme_list": [ "F1N338-1", "A0A3Q1LS03-1" ], "evidence": [ { "id": "R-BTA-77254", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77254" } ] }, { "id": "R-BTA-77312", "name": "(S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-77251" ], "output_participant_list": [], "enzyme_list": [ "F1N338-1", "A0A3Q1LS03-1" ], "evidence": [ { "id": "R-BTA-77312", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77312" } ] }, { "id": "R-BTA-77323", "name": "(S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-77322" ], "output_participant_list": [], "enzyme_list": [ "F1N338-1", "A0A3Q1LS03-1" ], "evidence": [ { "id": "R-BTA-77323", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77323" } ] }, { "id": "R-BTA-77331", "name": "(S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-77330" ], "output_participant_list": [], "enzyme_list": [ "F1N338-1", "A0A3Q1LS03-1" ], "evidence": [ { "id": "R-BTA-77331", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77331" } ] }, { "id": "R-BTA-77342", "name": "(S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-77341" ], "output_participant_list": [], "enzyme_list": [ "F1N338-1", "A0A3Q1LS03-1" ], "evidence": [ { "id": "R-BTA-77342", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77342" } ] }, { "id": "R-BTA-9838035", "name": "CLPXP binds mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "P15690-1", "P20000-1", "Q02337-1", "Q32LG3-1", "P20004-1", "A6QLI6-1", "P00829-1", "A7MB35-1", "F1MTT7-1", "Q148N0-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q04467-1", "Q0NXR6-1", "Q29RZ0-1", "Q3MHX5-1", "F1MXW5-1", "F1N155-1", "F1N338-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "F1N206-1", "Q3ZCH0-1", "Q2KHU4-1" ], "evidence": [ { "id": "R-BTA-9838035", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838035" } ] }, { "id": "R-BTA-9838081", "name": "LONP1 degrades mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "Q2KIE6-1", "P15690-1", "P20000-1", "Q32LG3-1", "P20004-1", "A0AAA9S896-1", "P00829-1", "Q5EAD4-1", "Q2TBR0-1", "F1MTT7-1", "Q148N0-1", "P11181-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q0NXR6-1", "Q29RZ0-1", "F1MXW5-1", "F1N338-1", "G3MWG4-1", "A0A140T871-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "O02691-1", "A0A3Q1LR42-1", "Q3ZCH0-1" ], "evidence": [ { "id": "R-BTA-9838081", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838081" } ] }, { "id": "R-BTA-9838093", "name": "LONP1 binds mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "Q2KIE6-1", "P15690-1", "P20000-1", "Q32LG3-1", "P20004-1", "A0AAA9S896-1", "P00829-1", "Q5EAD4-1", "Q2TBR0-1", "F1MTT7-1", "Q148N0-1", "P11181-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q0NXR6-1", "Q29RZ0-1", "F1MXW5-1", "F1N338-1", "G3MWG4-1", "A0A140T871-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "O02691-1", "A0A3Q1LR42-1", "Q3ZCH0-1" ], "evidence": [ { "id": "R-BTA-9838093", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838093" } ] }, { "id": "R-BTA-9838289", "name": "CLPXP degrades mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "P15690-1", "P20000-1", "Q02337-1", "Q32LG3-1", "P20004-1", "A6QLI6-1", "P00829-1", "A7MB35-1", "F1MTT7-1", "Q148N0-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q04467-1", "Q0NXR6-1", "Q29RZ0-1", "Q3MHX5-1", "F1MXW5-1", "F1N155-1", "F1N338-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "F1N206-1", "Q3ZCH0-1", "Q2KHU4-1" ], "evidence": [ { "id": "R-BTA-9838289", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838289" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-77251", "participant_name": "3HB-CoA [mitochondrial matrix]", "crossref": [ { "id": "57316", "database": "ChEBI", "url": "" }, { "id": "ZINC000008551316", "database": "ZINC", "url": "" }, { "id": "C01144", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-77252", "participant_name": "(S)-3-Hydroxydodecanoyl-CoA [mitochondrial matrix]", "crossref": [ { "id": "62558", "database": "ChEBI", "url": "" }, { "id": "ZINC000195755502", "database": "ZINC", "url": "" }, { "id": "C05262", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-77322", "participant_name": "(S)-Hydroxyhexanoyl-CoA [mitochondrial matrix]", "crossref": [ { "id": "62075", "database": "ChEBI", "url": "" }, { "id": "ZINC000096014539", "database": "ZINC", "url": "" }, { "id": "C05268", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-77330", "participant_name": "(S)-Hydroxyoctanoyl-CoA [mitochondrial matrix]", "crossref": [ { "id": "62617", "database": "ChEBI", "url": "" }, { "id": "ZINC000096085226", "database": "ZINC", "url": "" }, { "id": "C05266", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-77341", "participant_name": "(S)-Hydroxydecanoyl-CoA [mitochondrial matrix]", "crossref": [ { "id": "62616", "database": "ChEBI", "url": "" }, { "id": "ZINC000096014970", "database": "ZINC", "url": "" }, { "id": "C05264", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T871", "gene_name": "GLUD1", "activity": [ { "ec_number": "1.4.1.3", "activity": "L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+).", "evidence": [ { "id": "A0A140T871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T871" } ] }, { "ec_number": "1.4.1.3", "activity": "", "evidence": [ { "id": "A0A140T871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T871" } ] } ] }, { "uniprot_ac": "A0A3Q1LR42", "gene_name": "NADK2", "activity": [ { "ec_number": "2.7.1.23", "activity": "NAD(+) + ATP = ADP + NADP(+) + H(+).", "evidence": [ { "id": "A0A3Q1LR42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR42" } ] }, { "ec_number": "2.7.1.23", "activity": "", "evidence": [ { "id": "A0A3Q1LR42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR42" } ] } ] }, { "uniprot_ac": "A0A3Q1LS03", "gene_name": "", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0A3Q1LS03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "A0A3Q1LS03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ] } ] }, { "uniprot_ac": "A0A3Q1LS67", "gene_name": "ECH1", "activity": [ { "ec_number": "5.3.3.21", "activity": "a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA.", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] }, { "ec_number": "5.3.3.21", "activity": "", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] } ] }, { "uniprot_ac": "A0A3Q1LYU1", "gene_name": "PDK1", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "A0A3Q1LYU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ] } ] }, { "uniprot_ac": "A0A3Q1NDR1", "gene_name": "HADHA", "activity": [ { "ec_number": "4.2.1.17", "activity": "(3S)-3-hydroxyadipyl-CoA = (E)-2,3-didehydroadipoyl-CoA + H2O.", "evidence": [ { "id": "A0A3Q1NDR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDR1" } ] }, { "ec_number": "4.2.1.17", "activity": "", "evidence": [ { "id": "A0A3Q1NDR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDR1" } ] }, { "ec_number": "1.1.1.211", "activity": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) = a long-chain 3-oxo-fatty acyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0A3Q1NDR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDR1" } ] }, { "ec_number": "1.1.1.211", "activity": "", "evidence": [ { "id": "A0A3Q1NDR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDR1" } ] } ] }, { "uniprot_ac": "A0AAA9RY48", "gene_name": "HSD17B10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + NADH + H(+).", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.239", "activity": "testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+).", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.53", "activity": "androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + NADH + H(+).", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H(+).", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.159", "activity": "", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.178", "activity": "", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "A0AAA9RY48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY48" } ] } ] }, { "uniprot_ac": "A0AAA9S896", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "A0AAA9S896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S896" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "A0AAA9S896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S896" } ] } ] }, { "uniprot_ac": "A0AAA9SND8", "gene_name": "EHHADH", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "4.2.1.17", "activity": "(3S)-3-hydroxyadipyl-CoA = (E)-2,3-didehydroadipoyl-CoA + H2O.", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "4.2.1.17", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] } ] }, { "uniprot_ac": "A6QLI6", "gene_name": "ALAS1", "activity": [ { "ec_number": "2.3.1.37", "activity": "succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA.", "evidence": [ { "id": "A6QLI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLI6" } ] }, { "ec_number": "2.3.1.37", "activity": "", "evidence": [ { "id": "A6QLI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLI6" } ] } ] }, { "uniprot_ac": "A7MB35", "gene_name": "PDHA1", "activity": [ { "ec_number": "1.2.4.1", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "A7MB35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB35" } ] }, { "ec_number": "1.2.4.1", "activity": "", "evidence": [ { "id": "A7MB35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB35" } ] } ] }, { "uniprot_ac": "F1MTT7", "gene_name": "ECI1", "activity": [ { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "F1MTT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTT7" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "F1MTT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTT7" } ] } ] }, { "uniprot_ac": "F1MXW5", "gene_name": "OXSM", "activity": [ { "ec_number": "2.3.1.41", "activity": "a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2.", "evidence": [ { "id": "F1MXW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXW5" } ] }, { "ec_number": "2.3.1.41", "activity": "", "evidence": [ { "id": "F1MXW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXW5" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N206", "gene_name": "DLD", "activity": [ { "ec_number": "1.8.1.4", "activity": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+).", "evidence": [ { "id": "F1N206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N206" } ] }, { "ec_number": "1.8.1.4", "activity": "", "evidence": [ { "id": "F1N206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N206" } ] } ] }, { "uniprot_ac": "F1N338", "gene_name": "HADH", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ] } ] }, { "uniprot_ac": "G3MWG4", "gene_name": "IARS2", "activity": [ { "ec_number": "6.1.1.5", "activity": "tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate.", "evidence": [ { "id": "G3MWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWG4" } ] }, { "ec_number": "6.1.1.5", "activity": "", "evidence": [ { "id": "G3MWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWG4" } ] } ] }, { "uniprot_ac": "G3MWN1", "gene_name": "ARG2", "activity": [ { "ec_number": "3.5.3.1", "activity": "L-arginine + H2O = urea + L-ornithine.", "evidence": [ { "id": "G3MWN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWN1" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "G3MWN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWN1" } ] } ] }, { "uniprot_ac": "G3N0R5", "gene_name": "HSPD1", "activity": [ { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "G3N0R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0R5" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "G3N0R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0R5" } ] } ] }, { "uniprot_ac": "O02691", "gene_name": "HSD17B10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.239", "activity": "testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.53", "activity": "androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] } ] }, { "uniprot_ac": "P00829", "gene_name": "ATP5F1B", "activity": [ { "ec_number": "7.1.2.2", "activity": "ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out).", "evidence": [ { "id": "P00829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00829" } ] }, { "ec_number": "7.1.2.2", "activity": "", "evidence": [ { "id": "P00829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00829" } ] } ] }, { "uniprot_ac": "P11181", "gene_name": "DBT", "activity": [ { "ec_number": "2.3.1.168", "activity": "(2S)-2-methylbutanoyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] = N(6)-{(R)-S(8)-[(2S)-2-methylbutanoyl]dihydrolipoyl}-L-lysyl-[protein] + CoA.", "evidence": [ { "id": "P11181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11181" } ] }, { "ec_number": "2.3.1.168", "activity": "", "evidence": [ { "id": "P11181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11181" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P11181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11181" } ] } ] }, { "uniprot_ac": "P11966", "gene_name": "PDHB", "activity": [ { "ec_number": "1.2.4.1", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "P11966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11966" } ] }, { "ec_number": "1.2.4.1", "activity": "", "evidence": [ { "id": "P11966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11966" } ] } ] }, { "uniprot_ac": "P15690", "gene_name": "NDUFS1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] } ] }, { "uniprot_ac": "P20000", "gene_name": "ALDH2", "activity": [ { "ec_number": "1.2.1.3", "activity": "acetaldehyde + NAD(+) + H2O = acetate + NADH + 2 H(+).", "evidence": [ { "id": "P20000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20000" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P20000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20000" } ] } ] }, { "uniprot_ac": "P20004", "gene_name": "ACO2", "activity": [ { "ec_number": "4.2.1.3", "activity": "citrate = D-threo-isocitrate.", "evidence": [ { "id": "P20004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20004" } ] }, { "ec_number": "4.2.1.3", "activity": "", "evidence": [ { "id": "P20004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20004" } ] } ] }, { "uniprot_ac": "P22600", "gene_name": "FECH", "activity": [ { "ec_number": "4.98.1.1", "activity": "heme b + 2 H(+) = protoporphyrin IX + Fe(2+).", "evidence": [ { "id": "P22600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P22600" } ] }, { "ec_number": "4.98.1.1", "activity": "", "evidence": [ { "id": "P22600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P22600" } ] } ] }, { "uniprot_ac": "Q02337", "gene_name": "BDH1", "activity": [ { "ec_number": "1.1.1.30", "activity": "(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH + H(+).", "evidence": [ { "id": "Q02337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02337" } ] }, { "ec_number": "1.1.1.30", "activity": "", "evidence": [ { "id": "Q02337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02337" } ] } ] }, { "uniprot_ac": "Q04467", "gene_name": "IDH2", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "Q04467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q04467" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "Q04467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q04467" } ] } ] }, { "uniprot_ac": "Q0NXR6", "gene_name": "ACAD8", "activity": [ { "ec_number": "1.3.8.5", "activity": "2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "Q0NXR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0NXR6" } ] }, { "ec_number": "1.3.8.5", "activity": "", "evidence": [ { "id": "Q0NXR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0NXR6" } ] } ] }, { "uniprot_ac": "Q148N0", "gene_name": "OGDH", "activity": [ { "ec_number": "1.2.4.2", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "Q148N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148N0" } ] }, { "ec_number": "1.2.4.2", "activity": "", "evidence": [ { "id": "Q148N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148N0" } ] } ] }, { "uniprot_ac": "Q29RK1", "gene_name": "CS", "activity": [ { "ec_number": "2.3.3.1", "activity": "oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+).", 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"A0A3Q1LS71-1", "uniprot_ac": "A0A3Q1LS71", "uniprot_id": "A0A3Q1LS71_BOVIN", "mass": { "chemical_mass": 79901.0, "monoisotopic_mass": 79901.0 }, "refseq": { "ac": "XP_002691492", "name": "centrosomal protein of 68 kDa isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691492" }, "gene_names": [ { "name": "CEP68", "type": "recommended", "evidence": [ { "id": "A0A3Q1LS71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS71" } ] }, { "name": "CEP68", "type": "synonym", "evidence": [ { "id": "XP_002691492", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691492" } ] } ], "protein_names": [ { "name": "Centrosomal protein of 68 kDa", "type": "recommended", "evidence": [ { "id": "A0A3Q1LS71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS71/entry#names_and_taxonomy" } ] }, { "name": "centrosomal protein of 68 kDa isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002691492", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691492" } ] } ], "function": [ { "annotation": "Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase. Contributes to CROCC/rootletin filament formation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS71", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS71#function" }, { "database": "UniProtKB", "id": "ARBA00060188", "url": "https://www.uniprot.org/uniprotkb/ARBA00060188#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS71", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEP68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS71", "locus": { "chromosome": "11", "start_pos": 63468731, "end_pos": 63443956, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016717", "url": "https://www.ensembl.org/id/ENSBTAG00000016717" } ] } } ], "crossref": [ { "id": "A0A3Q1LS71", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LS71", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016717", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016717", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540684", "url": "https://www.ncbi.nlm.nih.gov/gene/540684", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "bta:540684", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540684", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LS71", "url": "https://www.orthodb.org/?gene=A0A3Q1LS71", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MPN3", "url": "https://www.orthodb.org/?gene=A0A3Q1MPN3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BPP3", "url": "https://www.orthodb.org/?gene=E1BPP3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14514", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14514", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14514:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14514:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_002691492", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691492", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS71", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS71-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPN3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MPN3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ42", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ42-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPP3", "url": "https://www.uniprot.org/uniprotkb/E1BPP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPP3-1", "url": "https://www.uniprot.org/uniprotkb/E1BPP3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALGAEKAEGEASSDTKAPSCGSWSRGEQELIPVGPVLGEQPPRLEAEGGPASPVEGTEGLPGPACYGGVGPGPSRACQPPASGASREPAAGGSKPAFGCVPSAGLETGDLPSAGSQMEETRLPAPEALPQTHAIPRAAALCLGHDADTEDDPSPVESPQVPDLCPQSPISGFPCPSRWRSAVSPGTPAPPSSSCSMSASSPGSSLQGHQEKAEPRSGCLAKVSSSLELAVPPSAPSVVSPGPRLQWLPQPVSSAGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRRSPLWNPNKEYEDLLDYTYPLRPGPRLPKQLDSHVLAEPVLQDSGIDLDSFSVSPASTLKSPTNVSHSCPPAEAAALSFSGPREPSLKRGPSGVPQKQGGVGLASCSLFASTPRAPSGRATPWVSREPARRNLRDWPPVGRHLELGSPRLRTRDKGWSSPGLEREKGASQGLRRLTCEESGWKPQEEVESDDEYLALPTRLTQVSSVISYLGSIPTLVPLSTDAAEGQSSLDVSDSDGPASLPSDSSQSQLPSGATLRGSWSAEDQKHCLRRSFVHARRSAREGSLVSSQALGVSSGPVRTRASWSAVLDPDAEGQPPRKGGEQGKESLVQCVQTFCCQLEELIHWLYNVADTTDHLTAPRSNLTGLKSSLQLYRQFKKDIDEHQSLTESVLQKGEILLQSLLDNTPVLKDVLGRISRQPSALESHADRLYDTILASLDTLAGCTLTPDSTPAAHRSTGVKGISLASSLNEM", "length": 759, "header": "tr|A0A3Q1LS71-1|A0A3Q1LS71_BOVIN Isoform 1 of Centrosomal protein of 68 kDa OS=Bos taurus OX=9913 GN=CEP68 PE=4 SV=1 CANONICAL=A0A3Q1LS71-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LS71-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS71/entry", "sequence": { "sequence": "MALGAEKAEGEASSDTKAPSCGSWSRGEQELIPVGPVLGEQPPRLEAEGGPASPVEGTEGLPGPACYGGVGPGPSRACQPPASGASREPAAGGSKPAFGCVPSAGLETGDLPSAGSQMEETRLPAPEALPQTHAIPRAAALCLGHDADTEDDPSPVESPQVPDLCPQSPISGFPCPSRWRSAVSPGTPAPPSSSCSMSASSPGSSLQGHQEKAEPRSGCLAKVSSSLELAVPPSAPSVVSPGPRLQWLPQPVSSAGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRRSPLWNPNKEYEDLLDYTYPLRPGPRLPKQLDSHVLAEPVLQDSGIDLDSFSVSPASTLKSPTNVSHSCPPAEAAALSFSGPREPSLKRGPSGVPQKQGGVGLASCSLFASTPRAPSGRATPWVSREPARRNLRDWPPVGRHLELGSPRLRTRDKGWSSPGLEREKGASQGLRRLTCEESGWKPQEEVESDDEYLALPTRLTQVSSVISYLGSIPTLVPLSTDAAEGQSSLDVSDSDGPASLPSDSSQSQLPSGATLRGSWSAEDQKHCLRRSFVHARRSAREGSLVSSQALGVSSGPVRTRASWSAVLDPDAEGQPPRKGGEQGKESLVQCVQTFCCQLEELIHWLYNVADTTDHLTAPRSNLTGLKSSLQLYRQFKKDIDEHQSLTESVLQKGEILLQSLLDNTPVLKDVLGRISRQPSALESHADRLYDTILASLDTLAGCTLTPDSTPAAHRSTGVKGISLASSLNEM", "length": 759, "header": "tr|A0A3Q1LS71-1|A0A3Q1LS71_BOVIN Isoform 1 of Centrosomal protein of 68 kDa OS=Bos taurus OX=9913 GN=CEP68 PE=4 SV=1 CANONICAL=A0A3Q1LS71-1" }, "locus": { "chromosome": "11", "start_pos": 63467727, "end_pos": 63455197, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083630.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083630.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063183.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063183.1" } ] } }, { "isoform_ac": "A0A3Q1MPN3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPN3/entry", "sequence": { "sequence": "MALGAEKAEGEASSDTKAPSCGSWSRGEQELIPVGPVLGEQPPRLEAEGGPASPVEGTEGLPGPACYGGVGPGPSRACQPPASGASREPAAGGSKPAFGCVPSAGLETGDLPSAGSQMEETRLPAPEALPQTHAIPRAAALCLGHDADTEDDPSPVESPQVPDLCPQSPISGFPCPSRWRSAVSPGTPAPPSSSCSMSASSPGSSLQGHQEKAEPRSGCLAKVSSSLELAVPPSAPSVVSPGPRLQWLPQPVSSAGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRRSPLWNPNKEYEDLLDYTYPLRPGPRLPKQLDSHVLAEPVLQDSGIDLDSFSVSPASTLKSPTNVSHSCPPAEAAALSFSGPREPSLKRGPSGVPQKQGGVGLASCSLFASTPRAPSGRATPWVSREPARRNLRDWPPVGRHLELGSPRLRTRDKGWSSPGLEREKGASQGLRRLTCEESGWKPQEEVESDDEYLALPTRLTQVSSVISYLGSIPTLVPLSTDAAEGQSSLDVSDSDGPASLPSDSSQSQLPSGATLRGSWSAEDQKHCLRRSFVHARRSAREGSLVSSQALGVSSGPVRTRASWSAVLDPDAEGQPPRKGGEQGKESLVQCVQQFKKDIDEHQSLTESVLQKGEILLQSLLDNTPVLKDVLGRISRQPSALESHADRLYDTILASLDTLAGCTLTPDSTPAAHRSTGVKGISLASSLNEM", "length": 718, "header": "tr|A0A3Q1MPN3-1|A0A3Q1LS71_BOVIN Computationally mapped isoform of Centrosomal protein of 68 kDa OS=Bos taurus OX=9913 GN=CEP68 PE=4 SV=1 CANONICAL=A0A3Q1LS71-1" }, "locus": { "chromosome": "11", "start_pos": 63467727, "end_pos": 63455197, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066452.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066452.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071614.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071614.1" } ] } }, { "isoform_ac": "A0AAA9SQ42-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ42/entry", "sequence": { "sequence": "MALGAEKAEGEASSDTKAPSCGSWSRGEQELIPVGPVLGEQPPRLEAEGGPASPVEGTEGLPGPACYGGVGPGPSRACQPPASGASREPAAGGSKPAFGCVPSAGLETGDLPSAGSQMEETRLPAPEALPQTHAIPRAAALCLGHDADTEDDPSPVESPQVPDLCPQSPISGFPCPSRWRSAVSPGTPAPPSSSCSMSASSPGSSLQGHQEKAEPRSGCLAKVSSSLELAVPPSAPSVVSPGPRLQWLPQPVSSAGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRRSPLWNPNKEYEDLLDYTYPLRPGPRLPKQLDSHVLAEPVLQDSGIDLDSFSVSPASTLKSPTNVSHSCPPAEAAALSFSGPREPSLKRGPSGVPQKQGGVGLASCSLFASTPRAPSGRATPWVSREPARRNLRDWPPVGRHLELGSPRLRTRDKGWSSPGLEREKGASQGLRRLTCEESGWKPQEEVESDDEYLALPTRLTQVSSVISYLGSIPTLVPLSTDAAEGQSSLDVSDSDGPASLPSDSSQSQLPSGATLRGSWSAEDQKHCLRRSFVHARRSAREGSLVSSQALGVSSGPVRTRASWSAVLDPDAEGQPPRKGGEQGKESLVQCVQTFCCQLEELIHWLYNVADTTDHLTAPRSNLTGLKSSLQLYRQFKKDIDEHQSLTESVLQKGEILLQSLLDNTPGFSPTGSGCEPGVLSLKLR", "length": 713, "header": "tr|A0AAA9SQ42-1|A0A3Q1LS71_BOVIN Computationally mapped isoform of Centrosomal protein of 68 kDa OS=Bos taurus OX=9913 GN=CEP68 PE=4 SV=1 CANONICAL=A0A3Q1LS71-1" }, "locus": { "chromosome": "11", "start_pos": 63466296, "end_pos": 63455197, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122517.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122517.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085048.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085048.1" } ] } }, { "isoform_ac": "E1BPP3-1", "url": "https://www.uniprot.org/uniprotkb/E1BPP3/entry", "sequence": { "sequence": "MALGAEKAEGEASSDTKAPSCGSWSRGEQELIPVGPVLGEQPPRLEAEGGPASPVEGTEGLPGPACYGGVGPGPSRACQPPASGASREPAAGGSKPAFGCVPSAGLETGDLPSAGSQMEETRLPAPEALPQTHAIPRAAALCLGHDADTEDDPSPVESPQVPDLCPQSPISGFPCPSRWRSAVSPGTPAPPSSSCSMSASSPGSSLQGHQEKAEPRSGCLAKVSSSLELAVPPSAPSVVSPGPRLQWLPQPVSSAGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRRSPLWNPNKEYEDLLDYTYPLRPGPRLPKQLDSHVLAEPVLQDSGIDLDSFSVSPASTLKSPTNVSHSCPPAEAAALSFSGPREPSLKRGPSGVPQKQGGVGLASCSLFASTPRAPSGRATPWVSREPARRNLRDWPPVGRHLELGSPRLRTRDKGWSSPGLEREKGASQGLRRLTCEESGWKPQEEVESDDEYLALPTRLTQVSSVISYLGSIPTLVPLSTDAAEGQSSLDVSDSDGPASLPSDSSQSQLPSGATLRGSWSAEDQKHCLRRSFVHARRSAREGSLVSSQALGVSSGPVRTRASWSAVLDPDAEGQPPRKGGEQGKESLVQCVQTFCCQLEELIHWLYNVADTTDHLTAPRSNLTGLKSSLQLYRQFKKDIDEHQSLTESVLQKGEILLQSLLDNTPDQTTRTY", "length": 701, "header": "tr|E1BPP3-1|A0A3Q1LS71_BOVIN Computationally mapped isoform of Centrosomal protein of 68 kDa OS=Bos taurus OX=9913 GN=CEP68 PE=4 SV=3 CANONICAL=A0A3Q1LS71-1" }, "locus": { "chromosome": "11", "start_pos": 63465383, "end_pos": 63455197, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022223.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022223.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022223.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022223.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 187, "start_aa": "Thr", "end_pos": 187, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr187", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 738, "start_aa": "Thr", "end_pos": 738, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr738", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:540684", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540684", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS71", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS71" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS71", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS71" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS71", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS71" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LS71", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS71" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "centriole-centriole cohesion", "id": "GO:0010457", "url": 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"phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:104968447", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:104968447", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "sulfotransferase activity", "id": "GO:0008146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008146", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSA8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "heparan sulfate proteoglycan biosynthetic process", "id": "GO:0015012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015012", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 383, "end_pos": 385, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LSA8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 450, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LSA8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LSA8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LSA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSA8" }, { "id": "PF00685", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00685" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sulfotransferase", "eco_id": "ECO_0000259", "start_pos": 192, "end_pos": 427, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 175, "end_pos": 177 }, { "start_pos": 312, "end_pos": 314 }, { "start_pos": 383, "end_pos": 385 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LSC2-1", "uniprot_ac": "A0A3Q1LSC2", "uniprot_id": "A0A3Q1LSC2_BOVIN", "mass": { "chemical_mass": 28561.0, "monoisotopic_mass": 28561.0 }, "refseq": { "ac": "XP_059730517", "name": "eukaryotic translation initiation factor 4E type 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730517" }, "gene_names": [ { "name": "EIF4E2", "type": "recommended", "evidence": [ { "id": "A0A3Q1LSC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC2" } ] }, { "name": "EIF4E2", "type": "synonym", "evidence": [ { "id": "XP_059730517", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730517" } ] } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 4E type 2", "type": "recommended", "evidence": [ { "id": "A0A3Q1LSC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC2/entry#names_and_taxonomy" } ] }, { "name": "Eukaryotic translation initiation factor 4E-like 3", "type": "synonym", "evidence": [ { "id": "A0A3Q1LSC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC2/entry#names_and_taxonomy" } ] }, { "name": "eIF4E-like protein 4E-LP", "type": "synonym", "evidence": [ { "id": "A0A3Q1LSC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC2/entry#names_and_taxonomy" } ] }, { "name": "eukaryotic translation initiation factor 4E type 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059730517", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730517" } ] } ], "function": [ { "annotation": "Component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In association with GIGYF2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSC2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC2#function" }, { "database": "UniProtKB", "id": "ARBA00054780", "url": "https://www.uniprot.org/uniprotkb/ARBA00054780#function" }, { "database": "UniProtKB", "id": "F6QXT5", "url": "https://www.uniprot.org/uniprotkb/F6QXT5#function" }, { "database": "UniProtKB", "id": "A0AAA9TS51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS51#function" } ] }, { "annotation": "Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation. In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. In P-bodies, component of a complex that promotes miRNA-mediated translational repression. Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSC2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC2#function" }, { "database": "UniProtKB", "id": "ARBA00054290", "url": "https://www.uniprot.org/uniprotkb/ARBA00054290#function" }, { "database": "UniProtKB", "id": "F6QXT5", "url": "https://www.uniprot.org/uniprotkb/F6QXT5#function" }, { "database": "UniProtKB", "id": "A0AAA9TS51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS51#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSC2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EIF4E2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC2", "locus": { "chromosome": "6", "start_pos": 71005689, "end_pos": 71129015, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000054466", "url": "https://www.ensembl.org/id/ENSBTAG00000054466" } ] } } ], "crossref": [ { "id": "A0A3Q1LSC2", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LSC2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010598", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010598", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "519920", "url": "https://www.ncbi.nlm.nih.gov/gene/519920", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSC2", "url": "https://www.orthodb.org/?gene=A0A3Q1LSC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6QXT5", "url": "https://www.orthodb.org/?gene=F6QXT5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11960", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11960", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11960:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11960:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01652", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01652", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1169408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059730517", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730517", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSC2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSC2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBF9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS51", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QXT5", "url": "https://www.uniprot.org/uniprotkb/F6QXT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QXT5-1", "url": "https://www.uniprot.org/uniprotkb/F6QXT5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSLLKIQRLKDDDSGDHDQNEENSTQKDGEKEKTERDKSQSSSKRKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKMPGRLGSQRLLFQNLWKPRLNVP", "length": 247, "header": "tr|A0A3Q1LSC2-1|A0A3Q1LSC2_BOVIN Isoform 1 of Eukaryotic translation initiation factor 4E type 2 OS=Bos taurus OX=9913 GN=EIF4E2 PE=3 SV=2 CANONICAL=A0A3Q1LSC2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSC2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC2/entry", "sequence": { "sequence": "MSSLLKIQRLKDDDSGDHDQNEENSTQKDGEKEKTERDKSQSSSKRKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKMPGRLGSQRLLFQNLWKPRLNVP", "length": 247, "header": "tr|A0A3Q1LSC2-1|A0A3Q1LSC2_BOVIN Isoform 1 of Eukaryotic translation initiation factor 4E type 2 OS=Bos taurus OX=9913 GN=EIF4E2 PE=3 SV=2 CANONICAL=A0A3Q1LSC2-1" }, "locus": { "chromosome": "2", "start_pos": 120205640, "end_pos": 120195095, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084173.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084173.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059919.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059919.2" } ] } }, { "isoform_ac": "A0AAA9TBF9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBF9/entry", "sequence": { "sequence": "MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKSQSSSKRKVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKAWEEFHGLVNSSGR", "length": 191, "header": "tr|A0AAA9TBF9-1|A0A3Q1LSC2_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 4E type 2 OS=Bos taurus OX=9913 GN=EIF4E2 PE=3 SV=1 CANONICAL=A0A3Q1LSC2-1" }, "locus": { "chromosome": "2", "start_pos": 120210564, "end_pos": 120187448, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090929.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090929.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093423.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093423.1" } ] } }, { "isoform_ac": "A0AAA9TS51-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS51/entry", "sequence": { "sequence": "MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKSQSSSKRKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKDNSSFRNTKITL", "length": 234, "header": "tr|A0AAA9TS51-1|A0A3Q1LSC2_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 4E type 2 OS=Bos taurus OX=9913 GN=EIF4E2 PE=3 SV=1 CANONICAL=A0A3Q1LSC2-1" }, "locus": { "chromosome": "2", "start_pos": 120215805, "end_pos": 120187448, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116679.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116679.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101207.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101207.1" } ] } }, { "isoform_ac": "F6QXT5-1", "url": "https://www.uniprot.org/uniprotkb/F6QXT5/entry", "sequence": { "sequence": "MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKSQSSSKRKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKFFLFFVLEYK", "length": 232, "header": "tr|F6QXT5-1|A0A3Q1LSC2_BOVIN Computationally mapped isoform of Eukaryotic translation initiation factor 4E type 2 OS=Bos taurus OX=9913 GN=EIF4E2 PE=3 SV=2 CANONICAL=A0A3Q1LSC2-1" }, "locus": { "chromosome": "2", "start_pos": 120205133, "end_pos": 120187448, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055491.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055491.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049866.3", "url": "https://www.ensembl.org/id/ENSBTAP00000049866.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1169408", "name": "", "url": 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"evidence": [ { "id": "A0A3Q1LSC6", "url": "https://omabrowser.org/oma/group/A0A3Q1LSC6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSC6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "complement component C3b binding", "id": "GO:0001851", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001851", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSC6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "complement activation", "id": "GO:0006956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006956", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSC6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LSC6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 278, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LSC6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LSC6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LSC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSC6" }, { "id": "PS50923", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50923" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sushi", "eco_id": "ECO_0000259", "start_pos": 94, "end_pos": 151, "start_aa": "Arg", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 70 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 135, "end_pos": 137 }, { "start_pos": 80, "end_pos": 82 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LSD7-1", "uniprot_ac": "A0A3Q1LSD7", "uniprot_id": "A0A3Q1LSD7_BOVIN", "mass": { "chemical_mass": 43924.0, "monoisotopic_mass": 43924.0 }, "refseq": {}, "gene_names": [ { "name": "ST8SIA5", "type": "recommended", "evidence": [ { "id": "A0A3Q1LSD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7" } ] } ], "protein_names": [ { "name": "Alpha-2,8-sialyltransferase 8E", "type": "recommended", "evidence": [ { "id": "A0A3Q1LSD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7/entry#names_and_taxonomy" } ] }, { "name": "Sialyltransferase 8E", "type": "synonym", "evidence": [ { "id": "A0A3Q1LSD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7/entry#names_and_taxonomy" } ] }, { "name": "Sialyltransferase St8Sia V", "type": "synonym", "evidence": [ { "id": "A0A3Q1LSD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, GP1c and GT3 from GD1a, GT1b, GM1b and GD3 respectively.", "evidence": [ { "database": "UniProtKB", "id": "F1N2J4", "url": "https://www.uniprot.org/uniprotkb/F1N2J4#function" }, { "database": "UniProtKB", "id": "ARBA00056957", "url": "https://www.uniprot.org/uniprotkb/ARBA00056957#function" }, { "database": "UniProtKB", "id": "A0AAA9T0U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U4#function" }, { "database": "UniProtKB", "id": "A0A3Q1LSD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ST8SIA5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7", "locus": { "chromosome": "24", "start_pos": 46418523, "end_pos": 46485864, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001770", "url": "https://www.ensembl.org/id/ENSBTAG00000001770" } ] } } ], "crossref": [ { "id": "A0A3Q1LSD7", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LSD7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001770", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001770", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23990", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23990", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "497020", "url": "https://www.ncbi.nlm.nih.gov/gene/497020", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MFICAFG", "url": "https://omabrowser.org/oma/group/MFICAFG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N2J4", "url": "https://www.orthodb.org/?gene=F1N2J4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11987", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11987", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11987:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11987:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00777", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00777", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-4085001", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085001", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9840309", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840309", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "47592", "url": "https://www.rhea-db.org/rhea/47592", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LSD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSD7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0U4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2J4", "url": "https://www.uniprot.org/uniprotkb/F1N2J4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2J4-1", "url": "https://www.uniprot.org/uniprotkb/F1N2J4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRYADPSANRDLLGNRTLLFIFICAFALVTLLQQILYGRNYIKRYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQLYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC", "length": 376, "header": "tr|A0A3Q1LSD7-1|A0A3Q1LSD7_BOVIN Isoform 1 of Alpha-2,8-sialyltransferase 8E OS=Bos taurus OX=9913 GN=ST8SIA5 PE=3 SV=1 CANONICAL=A0A3Q1LSD7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSD7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7/entry", "sequence": { "sequence": "MRYADPSANRDLLGNRTLLFIFICAFALVTLLQQILYGRNYIKRYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQLYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC", "length": 376, "header": "tr|A0A3Q1LSD7-1|A0A3Q1LSD7_BOVIN Isoform 1 of Alpha-2,8-sialyltransferase 8E OS=Bos taurus OX=9913 GN=ST8SIA5 PE=3 SV=1 CANONICAL=A0A3Q1LSD7-1" }, "locus": { "chromosome": "24", "start_pos": 46485487, "end_pos": 46419284, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070064.1", "url": "https://www.ensembl.org/id/ENSBTAT00000070064.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057992.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057992.1" } ] } }, { "isoform_ac": "A0AAA9T0U4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0U4/entry", "sequence": { "sequence": "MRYADPSANRDLLGNRTLLFIFICAFALVTLLQQILYGRNYIKRVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQLYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC", "length": 345, "header": "tr|A0AAA9T0U4-1|A0A3Q1LSD7_BOVIN Computationally mapped isoform of Alpha-2,8-sialyltransferase 8E OS=Bos taurus OX=9913 GN=ST8SIA5 PE=3 SV=1 CANONICAL=A0A3Q1LSD7-1" }, "locus": { "chromosome": "24", "start_pos": 46485487, "end_pos": 46419284, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133994.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133994.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090171.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090171.1" } ] } }, { "isoform_ac": "F1N2J4-1", "url": "https://www.uniprot.org/uniprotkb/F1N2J4/entry", "sequence": { "sequence": "MRYADPSANRDLLGNRTLLFIFICAFALVTLLQQILYGRNYIKRGLQFGWQSGDQLANWTGLFNVTDDPTVQSGSDSSSRYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQLYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC", "length": 412, "header": "tr|F1N2J4-1|A0A3Q1LSD7_BOVIN Computationally mapped isoform of Alpha-2,8-sialyltransferase 8E OS=Bos taurus OX=9913 GN=ST8SIA5 PE=3 SV=3 CANONICAL=A0A3Q1LSD7-1" }, "locus": { "chromosome": "24", "start_pos": 46485487, "end_pos": 46419284, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002317.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002317.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002317.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002317.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-4085001", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085001", "resource": "Reactome", "description": "Sialic acid metabolism" }, { "id": "R-BTA-9840309", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840309", "resource": "Reactome", "description": "Glycosphingolipid biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2TZK0-1", "protein_name": "Alpha-2,8-sialyltransferase 8E", "gene_name": "ST8SIA5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGYTDPSSGRDLLGNRTLFFIFICAFAVVTLLQQILYGRNYLKRYFEFYEGPLEYNSTKCLELRQDIIAVKVLSMVKQTELFDRWKSLQMCKWEMNVTEANILKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIFHINQEIFKMFPKDMPYHRSQFKKCAVVGNGGILKNSRCGREIDSADFVFRCNLPPISEKYLTDVGVKTDVVTVNPSIITERFHKLEKWRKPFYDVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESQQAVYYFHPQYLINVSRYWLGQGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGIFITHHYYDNVKPRPGFHAMPSEIFNFLHMHSKGILRVHTGTCGCC", "length": 376 }, "evidence": [ { "id": "A0A3Q1LSD7", "url": "https://omabrowser.org/oma/group/A0A3Q1LSD7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8W4FIM2-1", "protein_name": "Alpha-2,8-sialyltransferase 8E", "gene_name": "ST8SIA5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRYADPSASRDLLGNRTLLFIFICAFALVTLLQQILYGRNYIKRGLQFGWQSGDPLANWTGLLNVTEDPAVQSGNDSSSRYFEFYEGPFEYNSTRCLELRHEILEVKVLSMSTLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILATAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC", "length": 383 }, "evidence": [ { "id": "A0A3Q1LSD7", "url": "https://omabrowser.org/oma/group/A0A3Q1LSD7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O15466-1", "protein_name": "Alpha-2,8-sialyltransferase 8E", "gene_name": "ST8SIA5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRYADPSANRDLLGSRTLLFIFICAFALVTLLQQILYGRNYIKRYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC", "length": 376 }, "evidence": [ { "id": "A0A3Q1LSD7", "url": "https://omabrowser.org/oma/group/A0A3Q1LSD7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P70126-1", "protein_name": "Alpha-2,8-sialyltransferase 8E", "gene_name": "St8sia5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRYADPSANRDLLGNRTLLFIFICAFALVTLLQQILYSKSYIKRGFQFGWQRGDQQANWTGLFNDSDSPTEQNITGSSSRYFEFYKEPLEFNSTRCLELRQEILEVKVLSMVKQSELFERWKSLQICKWAMDTAEASLFKSTLSRCCNAPSFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTLVSFRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVKPKPGFHAMPSEIFTFLRMHSRGILRVHTGTCNCC", "length": 412 }, "evidence": [ { "id": "A0A3Q1LSD7", "url": "https://omabrowser.org/oma/group/A0A3Q1LSD7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ZXC8-1", "protein_name": "Alpha-2,8-sialyltransferase 8E", "gene_name": "St8sia5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRYADPSANRDLLGNRTLLFIFICAFALVTLLQQILYSKSYIKRYFEFYKEPLEFNSTRCLELRQEILEVKVLSMVKQSELFERWKSLQICKWAMDASEASLFKSTLSRCCNAPNFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTLVSFRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVKPKPGFHAMPSEIFTFLRMHSRGILRVHTGTCNCC", "length": 376 }, "evidence": [ { "id": "A0A3Q1LSD7", "url": "https://omabrowser.org/oma/group/A0A3Q1LSD7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity", "id": "GO:0003828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003828", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7" } ], "pmid": "" }, { "name": "sialyltransferase activity", "id": "GO:0008373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008373", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7" } ], "pmid": "" }, { "name": "oligosaccharide metabolic process", "id": "GO:0009311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009311", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7" } ], "pmid": "" }, { "name": "N-glycan processing", "id": "GO:0006491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006491", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7" } ], "pmid": "" }, { "name": "glycoprotein biosynthetic process", "id": "GO:0009101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009101", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSD7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 241, "end_pos": 243, "annotation": "n_glycosylation_sequon" }, { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "47592", "name": "", "equation": "a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GP1c (d18:1(4E)) + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "47592", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47592" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LSD7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 376, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LSD7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LSD7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G01044XE", "type": "N-linked", "subtype": "Complex" }, { 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"glytoucan_ac": "G70224BV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G75311QH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85002XD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87293AR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90721SF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G93910CU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99527BL", "type": "O-linked", "subtype": "Core 1" } ], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 15, "end_pos": 17 }, { "start_pos": 241, "end_pos": 243 }, { "start_pos": 284, "end_pos": 286 }, { "start_pos": 56, "end_pos": 58 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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"table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LSG0-1", "uniprot_ac": "A0A3Q1LSG0", "uniprot_id": "A0A3Q1LSG0_BOVIN", "mass": { "chemical_mass": 50331.0, "monoisotopic_mass": 50331.0 }, "refseq": { "ac": "XP_059734520", "name": "keratin, type I cytoskeletal 42 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734520" }, "gene_names": [ { "name": "KRT42", "type": "recommended", "evidence": [ { "id": "A0A3Q1LSG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG0" } ] }, { "name": "KRT42", "type": "synonym", "evidence": [ { "id": "XP_059734520", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734520" } ] } ], "protein_names": [ { "name": "IF rod domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0A3Q1LSG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG0/entry#names_and_taxonomy" } ] }, { "name": "keratin, type I cytoskeletal 42 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059734520", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734520" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRT42", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG0", "locus": {} } ], "crossref": [ { "id": "A0A3Q1LSG0", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LSG0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047262", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047262", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "101905591", "url": "https://www.ncbi.nlm.nih.gov/gene/101905591", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TDMREQY", "url": "https://omabrowser.org/oma/group/TDMREQY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSG0", "url": "https://www.orthodb.org/?gene=A0A3Q1LSG0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239:SF184", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239:SF184", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059734520", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734520", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSG0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAATTTSIRQFSTSGSVKGLCMPSGGFSRMSSIRVGGACRAPSLLGVGGSGNMSMSSSRFSMGLGGGYGGGYTCNLGGGFGSSFGTVDNLLGGSEKETMQNLNDRLASYLDKVRALEEANADLEVKIHDWYKKQGPGPARDYSHYFKTIEELRSKILAATIDNASLVLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLRKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNTEALQSSRTEITELRRTVQNLEIELQSQLSMKASLEGSLAETEARYGAQLAQLQGLISSIEAQLSELRCDMERQNHEYQVLLDVKTRLEQEISTYRRLLEGEDAHLSTQYSSSLASQPTREGTVTTRQVRTIMEEVQDGKVVSSREQVHRSTH", "length": 453, "header": "tr|A0A3Q1LSG0-1|A0A3Q1LSG0_BOVIN Isoform 1 of IF rod domain-containing protein OS=Bos taurus OX=9913 GN=KRT42 PE=1 SV=1 CANONICAL=A0A3Q1LSG0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSG0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG0/entry", "sequence": { "sequence": "MAATTTSIRQFSTSGSVKGLCMPSGGFSRMSSIRVGGACRAPSLLGVGGSGNMSMSSSRFSMGLGGGYGGGYTCNLGGGFGSSFGTVDNLLGGSEKETMQNLNDRLASYLDKVRALEEANADLEVKIHDWYKKQGPGPARDYSHYFKTIEELRSKILAATIDNASLVLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLRKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNTEALQSSRTEITELRRTVQNLEIELQSQLSMKASLEGSLAETEARYGAQLAQLQGLISSIEAQLSELRCDMERQNHEYQVLLDVKTRLEQEISTYRRLLEGEDAHLSTQYSSSLASQPTREGTVTTRQVRTIMEEVQDGKVVSSREQVHRSTH", "length": 453, "header": "tr|A0A3Q1LSG0-1|A0A3Q1LSG0_BOVIN Isoform 1 of IF rod domain-containing protein OS=Bos taurus OX=9913 GN=KRT42 PE=1 SV=1 CANONICAL=A0A3Q1LSG0-1" }, "locus": { "chromosome": "19", "start_pos": 41849264, "end_pos": 41842171, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074959.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074959.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059957.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059957.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287AHM5-1", "protein_name": "IF rod domain-containing protein", "gene_name": "LOC100737030", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATTTSIRQFSTSGSVKGLCVPGGGFSRVSSIRVGGACRAPSLLGAGTCGNMSMASSRFSAGLGGGYSGGYTCSLGGGFGSSFGVADALLGGSEKETMQNLNDRLASYLDKVRALEEANADLEVKIHDWYKKQGPGPARDYSAYFKTIEDLRSKILAATIDNANLVLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLRKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKIAEKNRKDAEDWFFSKTEELNREVATNTEALQSSRTEITELRRSVQNLEIELQSQLSMKASLEGSLAETEARYGAQLAQLQGLISSIEQQLCELRCDMERQNHEYQVLLDVKTRLEQEIATYRRLLEGEDAHLAAQYSSSLVSQPTREATVTTRQVRTIMEEVQDGKVVSSREQVHRSTH", "length": 452 }, "evidence": [ { "id": "A0A3Q1LSG0", "url": "https://omabrowser.org/oma/group/A0A3Q1LSG0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6IFU7-1", "protein_name": "Keratin, type I cytoskeletal 42", "gene_name": "Krt42", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASTTSIRQFSTSGSVKGLCAPGMGFSRMSSVRIGGACRAPSLLGGGSCSNMSVTSSRFSAGLGGSYGGGYTCSLGGGFGSSFGVSDALLGGSEKETMQNLNDRLATYLDRVRALEEANTDLEVKIREWYKKQGPGPARDYSPYFKTIEDLRNKILAATIDNASIVLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQIETLKEELAYLKKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEELNREVATNTEALQSSRTEITELRRSVQNLEIELQSQLSMKASLENSLAETEARYGAQLAQLQGLISSMEQQLCELRCDMERQNHEYQVLLDVKTRLEQEIATYRRLLEGEDAHLATQYSSSLASQASREGTVTSRQVRTIVEEVQDGKVVSSREQVHRSTH", "length": 452 }, "evidence": [ { "id": "A0A3Q1LSG0", "url": "https://omabrowser.org/oma/group/A0A3Q1LSG0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6IFX2-1", "protein_name": "Keratin, type I cytoskeletal 42", "gene_name": "Krt42", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASTTSVRQFSTSGSVKGLCAPGMGFSRMSSVRVGGACRAPSLLGGGSCGNMSVTSSRFSAGLGGGYGGGYTCSLGGGFGSSFGVSDALLGGSEKETMQNLNDRLATYLDRVRALEEANADLEVKIREWYKKQGPGPARDYSPYFKTIEDLRNKILAATIDNASIVLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQIESLKEELAYLRKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEELNREVATNTEALQSSRTEITELRRSVQNLEIELQSQLSMKASLENSLAETEARYGAQLAQLQGLISSVEQQLCELRCDMERQNHEYQVLLDVKTRLEQEIATYRRLLEGEDAHLATQYSSSLASQPSREGMVTSRQVRTIVEEVQDGKVVSSREQVHRSTH", "length": 452 }, "evidence": [ { "id": "A0A3Q1LSG0", "url": "https://omabrowser.org/oma/group/A0A3Q1LSG0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG0" } ], "pmid": "" }, { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "epithelial cell differentiation", "id": "GO:0030855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030855", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG0" } ], "pmid": "" }, { "name": "intermediate filament organization", "id": "GO:0045109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045109", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG0" } ], "pmid": "" }, { "name": "morphogenesis of an epithelium", "id": "GO:0002009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002009", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of skin epidermis", "id": "GO:0030280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030280", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LSG0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 453, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LSG0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LSG0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LSG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG0" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 95, "end_pos": 406, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 163, "end_pos": 165 }, { "start_pos": 52, "end_pos": 54 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { 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"yes" } }, { "uniprot_canonical_ac": "A0A3Q1LSH0-1", "uniprot_ac": "A0A3Q1LSH0", "uniprot_id": "A0A3Q1LSH0_BOVIN", "mass": { "chemical_mass": 132531.0, "monoisotopic_mass": 132531.0 }, "refseq": { "ac": "XP_002688045", "name": "RNA helicase Mov10l1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688045" }, "gene_names": [ { "name": "MOV10L1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "name": "MOV10L1", "type": "synonym", "evidence": [ { "id": "XP_002688045", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688045" } ] } ], "protein_names": [ { "name": "RNA helicase Mov10l1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.13", "type": "synonym", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0/entry#names_and_taxonomy" } ] }, { "name": "RNA helicase Mov10l1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002688045", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688045" } ] } ], "function": [ { "annotation": "ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0#function" }, { "database": "UniProtKB", "id": "ARBA00054623", "url": "https://www.uniprot.org/uniprotkb/ARBA00054623#function" }, { "database": "UniProtKB", "id": "A0AAA9SEE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEE6#function" }, { "database": "UniProtKB", "id": "A0AAA9SQJ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQJ7#function" }, { "database": "UniProtKB", "id": "G3X7G5", "url": "https://www.uniprot.org/uniprotkb/G3X7G5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MOV10L1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0", "locus": { "chromosome": "5", "start_pos": 119540816, "end_pos": 119477372, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020341", "url": "https://www.ensembl.org/id/ENSBTAG00000020341" } ] } } ], "crossref": [ { "id": "A0A3Q1LSH0", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LSH0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020341", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020341", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18078", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18078", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18808", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18808", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100139822", "url": "https://www.ncbi.nlm.nih.gov/gene/100139822", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041679", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041679", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049080", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049080", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100139822", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100139822", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LSH0", "url": "https://www.orthodb.org/?gene=A0A3Q1LSH0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NKR4", "url": "https://www.orthodb.org/?gene=A0A3Q1NKR4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3X7G5", "url": "https://www.orthodb.org/?gene=G3X7G5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45418", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45418", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45418:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45418:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13086", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13086", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13087", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13087", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21634", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21634", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002688045", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688045", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LSH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSH0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKR4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKR4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEE6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQJ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1B5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1B5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1B5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1B5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2D3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2D3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2D3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2D3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X7G5", "url": "https://www.uniprot.org/uniprotkb/G3X7G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X7G5-1", "url": "https://www.uniprot.org/uniprotkb/G3X7G5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRLAAKVVSFFWRKADCPEEEAGPLGPELVEGDTRLKTVQGVVTRYCSDYGMIDDLIYFSNEVVTSKVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWDDDSKSHGGGLSDPSPRVLIGCVTSLMDRAGYISQTTYFSLESVCEGFEPCKGDWVEAEYWIRPGTWSSEAISVKPLRYKRVDRVCVSSLCGRNGVIDDCIFFTLDSLKLPEGYTPRRHDVVSVVVVESSQSCYVWRALCMTPVQTWDFSPATETAEEVCGALLLKNKGDIEVTRMTNFGTLKEGESKNMVIWVENKGDVPQNLVSCKLGGWDKAKQFRFQMLDKAQVCPEVYPICVPEKEKDFADKNINSLDSCGESRTWQTLESSSVNSKEVSSGDCACKGENGVKEKNIPQKQVTESEPDGLIPAGGETRIVITCDAKNSGRCRELLLLCFSSFIIGRYLEVNVVSEEESLIAVREPFSWKKSKSSQVLASTKTTVVVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIHAEIELKEYNMSGVTLKRNGDLLVLEVPGLAESRPSLYAGDKLILKTQEYNGHVIEYIGYVVEIHEEDVTLKLNPEFEQAYNFEPMDVEFTYNRTTSRRCHFALEQVIHLGAKVLFPEEIILQPPQVTWNWTHAQDTKRDGQSTSKNRRAVKDQTKHAPEEHQAGAQDTPVPRAATTEASRLVSGSPKAREKFFNPMLNENQKLAVRRILSGDCRPIPYVLFGPPGTGKTVTIIEAILQVFHALPDSRILVCAPSNSAADLVCLRLHESRALRPGTMVRVNATCRFEETITEAIRPYCRDGEDVWKASRFRVLITTCSSAGLFYQIGLRVGHFTHVFVDEAGQASEPECLIPLGLVSDVSGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLMSRPAYLRDEDAFGACGAYNPLLVTKLVKNYRSHSALLALPSRLFYHRELEVCADPTVVASLLGWEKLPRKGFPLIFHGVRGNEAREGRSPSWFNPAEAVQVMRYCCMLARSVSSQVSARDIGVITPYRKQVEKIKILLRNVDLMDIKVGSVEEFQGQEYLVVIISTVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYTGCDLPPELQPLQK", "length": 1184, "header": "tr|A0A3Q1LSH0-1|A0A3Q1LSH0_BOVIN Isoform 1 of RNA helicase Mov10l1 OS=Bos taurus OX=9913 GN=MOV10L1 PE=3 SV=3 CANONICAL=A0A3Q1LSH0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSH0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0/entry", "sequence": { "sequence": "MLRLAAKVVSFFWRKADCPEEEAGPLGPELVEGDTRLKTVQGVVTRYCSDYGMIDDLIYFSNEVVTSKVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWDDDSKSHGGGLSDPSPRVLIGCVTSLMDRAGYISQTTYFSLESVCEGFEPCKGDWVEAEYWIRPGTWSSEAISVKPLRYKRVDRVCVSSLCGRNGVIDDCIFFTLDSLKLPEGYTPRRHDVVSVVVVESSQSCYVWRALCMTPVQTWDFSPATETAEEVCGALLLKNKGDIEVTRMTNFGTLKEGESKNMVIWVENKGDVPQNLVSCKLGGWDKAKQFRFQMLDKAQVCPEVYPICVPEKEKDFADKNINSLDSCGESRTWQTLESSSVNSKEVSSGDCACKGENGVKEKNIPQKQVTESEPDGLIPAGGETRIVITCDAKNSGRCRELLLLCFSSFIIGRYLEVNVVSEEESLIAVREPFSWKKSKSSQVLASTKTTVVVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIHAEIELKEYNMSGVTLKRNGDLLVLEVPGLAESRPSLYAGDKLILKTQEYNGHVIEYIGYVVEIHEEDVTLKLNPEFEQAYNFEPMDVEFTYNRTTSRRCHFALEQVIHLGAKVLFPEEIILQPPQVTWNWTHAQDTKRDGQSTSKNRRAVKDQTKHAPEEHQAGAQDTPVPRAATTEASRLVSGSPKAREKFFNPMLNENQKLAVRRILSGDCRPIPYVLFGPPGTGKTVTIIEAILQVFHALPDSRILVCAPSNSAADLVCLRLHESRALRPGTMVRVNATCRFEETITEAIRPYCRDGEDVWKASRFRVLITTCSSAGLFYQIGLRVGHFTHVFVDEAGQASEPECLIPLGLVSDVSGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLMSRPAYLRDEDAFGACGAYNPLLVTKLVKNYRSHSALLALPSRLFYHRELEVCADPTVVASLLGWEKLPRKGFPLIFHGVRGNEAREGRSPSWFNPAEAVQVMRYCCMLARSVSSQVSARDIGVITPYRKQVEKIKILLRNVDLMDIKVGSVEEFQGQEYLVVIISTVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYTGCDLPPELQPLQK", "length": 1184, "header": "tr|A0A3Q1LSH0-1|A0A3Q1LSH0_BOVIN Isoform 1 of RNA helicase Mov10l1 OS=Bos taurus OX=9913 GN=MOV10L1 PE=3 SV=3 CANONICAL=A0A3Q1LSH0-1" }, "locus": { "chromosome": "5", "start_pos": 119539812, "end_pos": 119477604, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073834.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073834.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058023.3", "url": "https://www.ensembl.org/id/ENSBTAP00000058023.3" } ] } }, { "isoform_ac": "A0A3Q1NKR4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKR4/entry", "sequence": { "sequence": "MLRLAAKVVSFFWRKADCPEEEAGPLGPELVEGDTRLKTVQGVVTRYCSDYGMIDDLIYFSNEVVTSKVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWDDDSKSHGGGLSDPSPRVLIGCVTSLMDRAGYISQTTYFSLESVCEGFEPCKGDWVEAEYWIRPGTWSSEAISVKPLRYKRVDRVCVSSLCGRNGVIDDCIFFTLDSLKLPEGYTPRRHDVVSVVVVESSQSCYVWRALCMTPVQTWDFSPATETAEEVCGALLLKNKGDIEVTRMTNFGTLKEGESKNMVIWVENKGDVPQNLVSCKLGGWDKAKQFRFQMLDKAQVCPEVYPICVPEKEKDFADKNINSLDSCGESRTWQTLESSSVNSKEVSSGDCACKGENGVKEKNIPQKQVTESEPDGLIPAGGETRIVITCDAKNSGRCRELLLLCFSSFIIGRYLEVNVVSEEESLIAVREPFSWKKSKSSQVLASTKTTVVVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIHAEIELKEYNMSGVTLKRNGDLLVLEVPGLAESRPSLYAGDKLILKTQEYNGHVIEYIGYVVEIHEEDVTLKLNPEFEQAYNFEPMDVEFTYNRTTSRRCHFALEQVIHLGAKVLFPEEIILQPPQVTWNWTHAQDTKRDGQSTSKNRRAVKDQTKHAPEEHQAGAQDTPVPRAATTEASRLVSGSPKAREKFFNPMLNENQKLAVRRILSGDCRPIPYVLFGPPGTGKTVTIIEAILQVFHALPDSRILVCAPSNSAADLVCLRLHESRALRPGTMVRVNATCRFEETITEAIRPYCRDGEDVWKASRFRVLITTCSSAGLFYQIGLRVGHFTHVFVDEAGQASEPECLIPLGLVSDVSGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLMSRPAYLRDEDAFGACGAYNPLLVTKLVKNYRSHSALLALPSRLFYHRELEVCADPTVVASLLGWEKLPRKGFPLIFHGVRGNEAREGRSPSWFNPAEAVQVMRYCCMLARSVSSQVSARDIGVITPYRKQVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYTGCDLPPELQPLQK", "length": 1148, "header": "tr|A0A3Q1NKR4-1|A0A3Q1LSH0_BOVIN Computationally mapped isoform of RNA helicase Mov10l1 OS=Bos taurus OX=9913 GN=MOV10L1 PE=3 SV=2 CANONICAL=A0A3Q1LSH0-1" }, "locus": { "chromosome": "5", "start_pos": 119539812, "end_pos": 119477604, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075796.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075796.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072959.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072959.2" } ] } }, { "isoform_ac": "A0AAA9SEE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEE6/entry", "sequence": { "sequence": "MLRLAAKVVSFFWRKADCPEEEAGPLGPELVEGDTRLKTVQGVVTRYCSDYGMIDDLIYFSNEVVTSKVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWDDDSKSHGGGLSDPSPRVLIGCVTSLMDRAGYISQTTYFSLESVCEGFEPCKGDWVEAEYWIRPGTWSSEAISVKPLRYKRVDRVCVSSLCGRNGVIDDCIFFTLDSLKLPEGYTPRRHDVVSVVVVESSQSCYVWRALCMTPVQTWDFSPATETAEEVCGALLLKNKGDIEVTRMTNFGTLKEGESKNMVIWVENKGDVPQNLVSCKLGGWDKAKQFRFQMLDKAQVCPEVYPICVPEKEKDFADKNINSLDSCGESRTWQTLESSSVNSKEVSSGDCACKGENGVKEKNIPQKQVTESEPDGLIPAGGETRIVITCDAKNSGRCRELLLLCFSSFIIGRYLEVNVVSEEESLIAVREPFSWKKSKSSQVLASTKTTVVVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIHAEIELKEYNMSGVTLKRNGDLLVLEVPGLAESRPSLYAGDKLILKTQEYNGHVIEYIGYVVEIHEEDVTLKLNPEFEQAYNFEPMDVEFTYNRTTSRRCHFALEQVIHLGAKVLFPEEIILQPPQVTWNWTHAQDTKRDGQSTSKNRRAVKDQTKHAPEEHQAGAQDTPVPRAATTEASRLVSGSPKAREKFFNPMLNENQKLAVRRILSGDCRPIPYVLFGPPGTGKTVTIIEAILQVFHALPDSRILVCAPSNSAADLVCLRLHESRALRPGTMVRVNATCRFEETITEAIRPYCRDGEDVWKASRFRVLITTCSSAGLFYQIGLRVGHFTHVFVDEAGQASEPECLIPLGLVSDVSGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLMSRPAYLRDEDAFGACGAYNPLLGNEAREGRSPSWFNPAEAVQVMRYCCMLARSVSSQVSARDIGVITPYRKQVEKIKILLRNVDLMDIKVGSVEEFQGQEYLVVIISTVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYTGCDLPPELQPLQK", "length": 1126, "header": "tr|A0AAA9SEE6-1|A0A3Q1LSH0_BOVIN Computationally mapped isoform of RNA helicase Mov10l1 OS=Bos taurus OX=9913 GN=MOV10L1 PE=3 SV=1 CANONICAL=A0A3Q1LSH0-1" }, "locus": { "chromosome": "5", "start_pos": 119539812, "end_pos": 119477604, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131598.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131598.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081962.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081962.1" } ] } }, { "isoform_ac": "A0AAA9SQJ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQJ7/entry", "sequence": { "sequence": "MLRLAAKVVSFFWRKADCPEEEAGPLGPELVEGDTRLKTVQGVVTRYCSDYGMIDDLIYFSNEVVTSKVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWDDDSKSHGGGLSDPSPRVLIGCVTSLMDRAGYISQTTYFSLESVCEGFEPCKGDWVEAEYWIRPGTWSSEAISVKPLRYKRVDRVCVSSLCGRNGVIDDCIFFTLDSLKLPEGYTPRRHDVVSVVVVESSQSCYVWRALCMTPVQTWDFSPATETAEEVCGALLLKNKGDIEVTRMTNFGTLKEGESKNMVIWVENKGDVPQNLVSCKLGGWDKAKQFRFQMLDKAQVCPEVYPICVPEKEKDFADKNINSLDSCGESRTWQTLESSSVNSKEVSSGDCACKGENGVKEKNIPQKQVTESEPDGLIPAGGETRIVITCDAKNSGRCRELLLLCFSSFIIGRYLEVNVVSEEESLIAVREPFSWKKSKSSQVLASTKTTVVVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILTFQPLLAEIHEEDVTLKLNPEFEQAYNFEPMDVEFTYNRTTSRRCHFALEQVIHLGAKVLFPEEIILQPPQVTWNWTHAQDTKRDGQSTSKNRRAVKDQTKHAPEEHQAGAQDTPVPRAATTEASRLVSGSPKAREKFFNPMLNENQKLAVRRILSGDCRPIPYVLFGPPGTGKTVTIIEAILQVFHALPDSRILVCAPSNSAADLVCLRLHESRALRPGTMVRVNATCRFEETITEAIRPYCRDGEDVWKASRFRVLITTCSSAGLFYQIGLRVGHFTHVFVDEAGQASEPECLIPLGLVSDVSGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLMSRPAYLRDEDAFGACGAYNPLLVTKLVKNYRSHSALLALPSRLFYHRELEVCADPTVVASLLGWEKLPRKGFPLIFHGVRGNEAREGRSPSWFNPAEAVQVMRYCCMLARSVSSQVSARDIGVITPYRKQVEKIKILLRNVDLMDIKVGSVEEFQGQEYLVVIISTVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYTGCDLPPELQPLQK", "length": 1101, "header": "tr|A0AAA9SQJ7-1|A0A3Q1LSH0_BOVIN Computationally mapped isoform of RNA helicase Mov10l1 OS=Bos taurus OX=9913 GN=MOV10L1 PE=3 SV=1 CANONICAL=A0A3Q1LSH0-1" }, "locus": { "chromosome": "5", "start_pos": 119539812, "end_pos": 119477604, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128945.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128945.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085220.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085220.1" } ] } }, { "isoform_ac": "A0AAA9U1B5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1B5/entry", "sequence": { "sequence": "MLRLAAKVVSFFWRKADCPEEEAGPLGPELVEGDTRLKTVQGVVTRYCSDYGMIDDLIYFSNEVVTSKVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWDDDSKSHGGGLSDPSPRVLIGCVTSLMDRAGYISQTTYFSLESVCEGFEPCKGDWVEAEYWIRPGTWSSEAISVKPLRYKRVDRVCVSSLCGRNGVIDDCIFFTLDSLKLPEGYTPRRHDVVSVVVVESSQSCYVWRALCMTPVQTWDFSPATETAEEVCGALLLKNKGDIEVTRMTNFGTLKEGESKNMVIWVENKGDVPQNLVSCKLGGWDKAKQFRFQMLDKAQVCPEVYPICVPEKEKDFADKNINSLDSCGESRTWQTLESSSVNSKEVSSGDCACKGENGVKEKNIPQKQVTESEPDGLIPAGGETRIVITCDAKNSGRCRELLLLCFSSFIIGRYLEVNVVSEEESLIAVREPFSWKKSKSSQVLASTKTTVVVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIHAEIELKEYNMSGVTLKRNGDLLVLEVPGLAESRPSLYAGDKLILKTQEYNGHVIEYIGYVVEIHEEDVTLKLNPEFEQAYNFEPMDVEFTYNRTTSRRCHFALEQVIHLGAKVLFPEEIILQPPQVTWNWTHAQDTKRDGQSTSKNRRAVKDQTKHAPEEHQAGAQDTPVPRAATTEASRLVSGSPKAREKFFNPMLNENQKLAVRRILSGDCRPIPYVLFGPPGTGKTVTIIEAILQVFHALPDSRILVCAPSNSAADLVCLRLHESRALRPGTMVRVNATCRFEETITEAIRPYCRDGEDVWKASRFRVLITTCSSAGLFYQIGLRVGHFTHVFVDEAGQASEPECLIPLGLVSDVSGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLMSRPAYLRDEDAFGACGAYNPLLVTKLVKNYRSHSALLALPSRLFYHRELEVCADPTVVASLLGWEKLPRKGFPLIFHGVRVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYTGCDLPPELQPLQK", "length": 1098, "header": "tr|A0AAA9U1B5-1|A0A3Q1LSH0_BOVIN Computationally mapped isoform of RNA helicase Mov10l1 OS=Bos taurus OX=9913 GN=MOV10L1 PE=3 SV=1 CANONICAL=A0A3Q1LSH0-1" }, "locus": { "chromosome": "5", "start_pos": 119539812, "end_pos": 119477604, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103642.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103642.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103853.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103853.1" } ] } }, { "isoform_ac": "A0ABI0P2D3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2D3/entry", "sequence": { "sequence": "MLRLAAKVVSFFWRKADCPEEEAGPLGPELVEGDTRLKTVQGVVTRYCSDYGMIDDLIYFSNEVVTSKVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWDDDSKSHGGGLSDPSPRVLIGCVTSLMDRAGYISQTTYFSLESVCEGFEPCKGDWVEAEYWIRPGTWSSEAISVKPLRYKRVDRVCVSSLCGRNGVIDDCIFFTLDSLKLPEGYTPRRHDVVSVVVVESSQSCYVWRALCMTPVQTWDFSPATETAEEVCGALLLKNKGDIEVTRMTNFGTLKEGESKNMVIWVENKGDVPQNLVSCKLGGWDKAKQFRFQMLDKAQVCPEVYPICVPEKEKDFADKNINSLDSCGESRTWQTLESSSVNSKEVSSGDCACKGENGVKEKNIPQKQVTESEPDGLIPAGGETRIVITCDAKNSGRCRELLLLCFSSFIIGRYLEVNVVSEEESLIAVREPFSWKKSKSSQVLASTKTTVVVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIHAEIELKEYNMSGVTLKRNGDLLVLEVPGLAESRPSLYAGDKLILKTQEYNGHVIEYIGYVVEIHEEDVTLKLNPEFEQAYNFEPMDVEFTYNRTTSRRCHFALEQVIHLGAKVLFPEEIILQPPQVTWNWTHAQDTKRDGQSTSKNRRAVKDQTKHAPEEHQAGAQDTPVPRAATTEASRLVSGSPKAREKFFNPMLNENQKLAVRRILSGDCRPIPYVLFGPPGTGKTVTIIEAILQVFHALPDSRILVCAPSNSAADLVCLRLHESRALRPGTMVRVNATCRFEETITEAIRPYCRDGEDVWKASRFRVLITTCSSAGLFYQIGLRVGHFTHVFVDEAGQASEPECLIPLGLVSDVSGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLMSRPAYLRDEDAFGACGAYNPLLVTKLVKNYRSHSALLALPSRLFYHRELEVCADPTVVASLLGWEKLPRKGFPLIFHGVRGNEAREGRSPSWFNPAEAVQVMRYCCMLARSVSSQVSARDIGVITPYRKQVEKIKILLRNVDLMDIKVGSVEEFQGQEYLVVIISTVGACPDPHGPRVLTAGRSHLHCRRLPRPARAPRVLTAGRSHLHCRRLPGPARALEYSLQGVLISTVGACPGPHGPRVLTAGRSHLHCRRLPRPARAPRVLTAGRSHLHCRRLPRPARALEYSLQGALISTVGACPGPHGPLEYSLQGVLYRVPGRSAWGEGNGTPLQYSCLESPRDGGAWCAAVHGVARSRTRLSDFTFTFHFPALEKEMATHSSTLAWRVPGTRQPVGCRLWGHTESDTTDVT", "length": 1351, "header": "tr|A0ABI0P2D3-1|A0ABI0P2D3_BOVIN Computationally mapped isoform of RNA helicase OS=Bos taurus OX=9913 GN=MOV10L1 PE=3 SV=1 CANONICAL=A0A3Q1LSH0-1" }, "locus": { "chromosome": "5", "start_pos": 119539123, "end_pos": 119477604, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144160.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144160.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104978.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104978.1" } ] } }, { "isoform_ac": "G3X7G5-1", "url": "https://www.uniprot.org/uniprotkb/G3X7G5/entry", "sequence": { "sequence": "MLRLAAKVVSFFWRKADCPEEEAGPLGPELVEGDTRLKTVQGVVTRYCSDYGMIDDLIYFSNEVVTSKVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWDDDSKSHGGGLSDPSPRVLIGCVTSLMDRAGYISQTTYFSLESVCEGFEPCKGDWVEAEYWIRPGTWSSEAISVKPLRYKRVDRVCVSSLCGRNGVIDDCIFFTLDSLKLPEGYTPRRHDVVSVVVVESSQSCYVWRALCMTPVQTWNKGDVPQNLVSCKLGGWDKAKQFRFQMLDKAQVCPEVYPICVPEKEKDFADKNINSLDSCGESRTWQTLESSSVNSKEVSSGDCACKGENGVKEKNIPQKQVTESEPDGLIPAGGETRIVITCDAKNSGRCRELLLLCFSSFIIGRYLEVNVVSEEESLIAVREPFSWKKSKSSQVLASTKTTVVVTTQKRNSRRQLPSFLPQYPIPDRLKKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIHAEIELKEYNMSGVTLKRNGDLLVLEVPGLAESRPSLYAGDKLILKTQEYNGHVIEYIGYVVEIHEEDVTLKLNPEFEQAYNFEPMDVEFTYNRTTSRRCHFALEQVIHLGAKVLFPEEIILQPPQVTWNWTHAQDTKRDGQSTSKNRRAVKDQTKHAPEEHQAGAQDTPVPRAATTEASRLVSGSPKAREKFFNPMLNENQKLAVRRILSGDCRPIPYVLFGPPGTGKTVTIIEAILQVFHALPDSRILVCAPSNSAADLVCLRLHESRALRPGTMVRVNATCRFEETITEAIRPYCRDGEDVWKASRFRVLITTCSSAGLFYQIGLRVGHFTHVFVDEAGQASEPECLIPLGLVSDVSGQIVLAGDPMQLGPVIKSRLAMAYGLNVSMLERLMSRPAYLRDEDAFGACGAYNPLLVTKLVKNYRSHSALLALPSRLFYHRELEVCADPTVVASLLGWEKLPRKGFPLIFHGVRGNEAREGRSPSWFNPAEAVQVMRYCCMLARSVSSQVSARDIGVITPYRKQVEKIKILLRNVDLMDIKVGSVEEFQGQEYLVVIISTVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYTGCDLPPELQPLQK", "length": 1136, "header": "tr|G3X7G5-1|A0A3Q1LSH0_BOVIN Computationally mapped isoform of RNA helicase Mov10l1 OS=Bos taurus OX=9913 GN=MOV10L1 PE=3 SV=3 CANONICAL=A0A3Q1LSH0-1" }, "locus": { "chromosome": "5", "start_pos": 119539812, "end_pos": 119477604, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027109.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027109.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027109.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027109.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:100139822", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100139822", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ], "pmid": "" }, { "name": "P granule", "id": "GO:0043186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043186", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSH0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ], "pmid": "" }, { "name": "regulatory 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} ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": 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"3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", 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"ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": 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"ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", 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"glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 529, "end_pos": 531 }, { "start_pos": 556, "end_pos": 558 }, { "start_pos": 639, "end_pos": 641 }, { "start_pos": 676, "end_pos": 678 }, { "start_pos": 827, "end_pos": 829 }, { "start_pos": 933, "end_pos": 935 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LSJ3-1", "uniprot_ac": "A0A3Q1LSJ3", "uniprot_id": "A0A3Q1LSJ3_BOVIN", "mass": { "chemical_mass": 94878.0, "monoisotopic_mass": 94878.0 }, "refseq": { "ac": "XP_002696970", "name": "rab effector MyRIP", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696970" }, "gene_names": [ { "name": "MYRIP", "type": "recommended", "evidence": [ { "id": "A0A3Q1LSJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" } ] }, { "name": "MYRIP", "type": "synonym", "evidence": [ { "id": "XP_002696970", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696970" } ] } ], "protein_names": [ { "name": "Myosin VIIA and Rab interacting protein", "type": "synonym", "evidence": [ { "id": "A0A3Q1LSJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3/entry#names_and_taxonomy" } ] }, { "name": "rab effector MyRIP", "type": "synonym", "evidence": [ { "id": "XP_002696970", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696970" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYRIP", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3", "locus": { "chromosome": "22", "start_pos": 13149135, "end_pos": 12923253, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009430", "url": "https://www.ensembl.org/id/ENSBTAG00000009430" } ] } } ], "crossref": [ { "id": "A0A3Q1LSJ3", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LSJ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009430", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009430", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "522113", "url": "https://www.ncbi.nlm.nih.gov/gene/522113", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006788", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006788", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051745", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051745", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522113", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522113", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IHSGTQD", "url": "https://omabrowser.org/oma/group/IHSGTQD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSJ3", "url": "https://www.orthodb.org/?gene=A0A3Q1LSJ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14555", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14555", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14555:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14555:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02318", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02318", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04698", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04698", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9824585", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9824585", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002696970", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696970", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY31", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY31-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY31-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH74", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH74-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MET5", "url": "https://www.uniprot.org/uniprotkb/F1MET5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MET5-1", "url": "https://www.uniprot.org/uniprotkb/F1MET5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRKLDLSGLTDDETEHVLQVVQRDFNLRKREEERLSEMKQRLDAEGSKCSILSKHQKFVEHCCMRCCAPFTFLISTKRRCGDCKFNVCKGCCSYQKREKVWVCCVCQQARVLRTQSLEWFYNNVKSRFKRFGSAKVLKNLYRKHRLESGVCFDIVGGNFFEANLENEGSVSGSDSTFYRQSEGHSMMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTILQKIIRKQKSKSEQRAEDEPEWPQPQSCGAEAADAGTTAAPGGPQASTTFWRSQSAFSLSREDALRTPSLEAASREPREQHPREEEALPSWKSVDRLDQTMVAPVLQSPDGNWIALKDGALPPARLLAKPKSDAFQALEAASSVASAYDELGSDSEEDFDWREALSTLCLQPRALPGEPQTQPTQAPGSDQGPSASSGPSPNPEAMWSDSETSSVGSSREAGHRARLSWLQRKAPRNPAAEKMRLQGELDVNFNLQAAGRETSDSSEPEEAPHAADRRARRWRRARGCSEELSKELPSPSGHPPELDTHQVPGGLSETDTSSEARHPRASTDTTEEKRRNRLYELARKMSEKETSSGEDQESEPKTESENRKESLSSEDNSQSVQEELKKKYSAVSLCNISTEVLKVINATEELIAESAGPWEFPPVPPDREKGTFPLGTDQARLDEQLTSLEENVYLAAGTVYGLEGQLSELEDAARCIHSGTDETELADLEDQVATAAAQVHHAEIQISDIESRISALTNAGLNIAPCGRLTRKRNQKQRNQVQTIDTSRHQRRKLPAPPVKAEKIEASSTATIKTFNRNFILQDSSTNGTKERNSTPKDLIEPTLESAVMC", "length": 854, "header": "tr|A0A3Q1LSJ3-1|A0A3Q1LSJ3_BOVIN Isoform 1 of Myosin VIIA and Rab interacting protein OS=Bos taurus OX=9913 GN=MYRIP PE=4 SV=1 CANONICAL=A0A3Q1LSJ3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3/entry", "sequence": { "sequence": "MGRKLDLSGLTDDETEHVLQVVQRDFNLRKREEERLSEMKQRLDAEGSKCSILSKHQKFVEHCCMRCCAPFTFLISTKRRCGDCKFNVCKGCCSYQKREKVWVCCVCQQARVLRTQSLEWFYNNVKSRFKRFGSAKVLKNLYRKHRLESGVCFDIVGGNFFEANLENEGSVSGSDSTFYRQSEGHSMMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTILQKIIRKQKSKSEQRAEDEPEWPQPQSCGAEAADAGTTAAPGGPQASTTFWRSQSAFSLSREDALRTPSLEAASREPREQHPREEEALPSWKSVDRLDQTMVAPVLQSPDGNWIALKDGALPPARLLAKPKSDAFQALEAASSVASAYDELGSDSEEDFDWREALSTLCLQPRALPGEPQTQPTQAPGSDQGPSASSGPSPNPEAMWSDSETSSVGSSREAGHRARLSWLQRKAPRNPAAEKMRLQGELDVNFNLQAAGRETSDSSEPEEAPHAADRRARRWRRARGCSEELSKELPSPSGHPPELDTHQVPGGLSETDTSSEARHPRASTDTTEEKRRNRLYELARKMSEKETSSGEDQESEPKTESENRKESLSSEDNSQSVQEELKKKYSAVSLCNISTEVLKVINATEELIAESAGPWEFPPVPPDREKGTFPLGTDQARLDEQLTSLEENVYLAAGTVYGLEGQLSELEDAARCIHSGTDETELADLEDQVATAAAQVHHAEIQISDIESRISALTNAGLNIAPCGRLTRKRNQKQRNQVQTIDTSRHQRRKLPAPPVKAEKIEASSTATIKTFNRNFILQDSSTNGTKERNSTPKDLIEPTLESAVMC", "length": 854, "header": "tr|A0A3Q1LSJ3-1|A0A3Q1LSJ3_BOVIN Isoform 1 of Myosin VIIA and Rab interacting protein OS=Bos taurus OX=9913 GN=MYRIP PE=4 SV=1 CANONICAL=A0A3Q1LSJ3-1" }, "locus": { "chromosome": "22", "start_pos": 13148131, "end_pos": 12954886, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068769.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068769.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059992.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059992.1" } ] } }, { "isoform_ac": "A0AAA9RY31-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY31/entry", "sequence": { "sequence": "MGRKLDLSGLTDDETEHVLQVVQRDFNLRKREEERLRVLRTQSLEWFYNNVKSRFKRFGSAKVLKNLYRKHRLESGVCFDIVGGNFFEANLENEGSVSGSDSTFYRQSEGHSMMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTILQKIIRKQKSKSEQRAEDEPEWPQPQSCGAEAADAGTTAAPGGPQASTTFWRSQSAFSLSREDALRTPSLEAASREPREQHPREEEALPSWKSVDRLDQTMVAPVLQSPDGNWIALKDGALPPARLLAKPKSDAFQALEAASSVASAYDELGSDSEEDFDWREALSTLCLQPRALPGEPQTQPTQAPGSDQGPSASSGPSPNPEAMWSDSETSSVGSSREAGHRARLSWLQRKAPRNPAAEKMRLQGELDVNFNLQAAGRETSDSSEPEEAPHAADRRARRWRRARGCSEELSKELPSPSGHPPELDTHQVPGGLSETDTSSEARHPRASTDTTEEKRRNRLYELARKMSEKETSSGEDQESEPKTESENRKESLSSEDNSQSVQEELKKKYSAVSLCNISTEVLKVINATEELIAESAGPWEFPPVPPDREKGTFPLGTDQARLDEQLTSLEENVYLAAGTVYGLEGQLSELEDAARCIHSGTDETELADLEDQVATAAAQVHHAEIQISDIESRISALTNAGLNIAPCGRLTRKRNQKQRNQVQTIDTSRHQRRKLPAPPVKAEKIEASSTATIKTFNRNFILQDSSTNGTKERNSTPKDLIEPTLESAVMC", "length": 780, "header": "tr|A0AAA9RY31-1|A0A3Q1LSJ3_BOVIN Computationally mapped isoform of Myosin VIIA and Rab interacting protein OS=Bos taurus OX=9913 GN=MYRIP PE=4 SV=1 CANONICAL=A0A3Q1LSJ3-1" }, "locus": { "chromosome": "22", "start_pos": 13148131, "end_pos": 12954886, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119714.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119714.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078453.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078453.1" } ] } }, { "isoform_ac": "A0AAA9SH74-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH74/entry", "sequence": { "sequence": "TRKAASAASSPSTRSSWSTAACAAARLSPSSSAPSAAVGTVSSTSARAAAPTRSARRCGSAVSASRRGGNFFEANLENEGSVSGSDSTFYRQSEGHSMMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTILQKIIRKQKSKSEQRAEDEPEWPQPQSCGAEAADAGTTAAPGGPQASTTFWRSQSAFSLSREDALRTPSLEAASREPREQHPREEEALPSWKSVDRLDQTMVAPVLQSPDGNWIALKDGALPPARLLAKPKSDAFQALEAASSVASAYDELGSDSEEDFDWREALSTLCLQPRALPGEPQTQPTQAPGSDQGPSASSGPSPNPEAMWSDSETSSVGSSREAGHRARLSWLQRKAPRNPAAEKMRLQGELDVNFNLQAAGRETSDSSEPEEAPHAADRRARRWRRARGCSEELSKELPSPSGHPPELDTHQVPGGLSETDTSSEARHPRASTDTTEEKRRNRLYELARKMSEKETSSGEDQESEPKTESENRKESLSSEDNSQSVQEELKKKYSAVSLCNISTEVLKVINATEELIAESAGPWEFPPVPPDREKGTFPLGTDQARLDEQLTSLEENVYLAAGTVYGLEGQLSELEDAARCIHSGTDETELADLEDQVATAAAQVHHAEIQISDIESRISALTNAGLNIAPCGRLTRKRNQKQRNQVQTIDTSRHQRRKLPAPPVKAEKIEASSTATIKTFNRNFILQDSSTNGTKERNSTPKDLIEPTLESAVMC", "length": 765, "header": "tr|A0AAA9SH74-1|A0A3Q1LSJ3_BOVIN Computationally mapped isoform of Myosin VIIA and Rab interacting protein OS=Bos taurus OX=9913 GN=MYRIP PE=4 SV=1 CANONICAL=A0A3Q1LSJ3-1" }, "locus": { "chromosome": "22", "start_pos": 13148131, "end_pos": 13031319, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089468.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089468.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083048.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083048.1" } ] } }, { "isoform_ac": "F1MET5-1", "url": "https://www.uniprot.org/uniprotkb/F1MET5/entry", "sequence": { "sequence": "MGRKLDLSGLTDDETEHVLQVVQRDFNLRKREEERLSEMKQRLDAEGSKCSILSKHQKFVEHCCMRCCAPFTFLISTKRRCGDCKFNVCKGCCSYQKREKVWVCCVCQQARVLRTQSLEWFYNNVKSRFKRFGSAKVLKNLYRKHRLESGVCFDIVGGNFFEANLENEGSVSGSDSTFYRQSEGHSMMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTILQKIIRKQKSKSEQRAEDEPEWPQPQSCGAEAADAGTTAAPGGPQASTTFWRSQSAFSLSREDALRTPSLEAASREPREQHPREEEALPSWKSVDRLDQTMVAPVLQSPDGNWIALKDGALPPARLLAKPKSDAFQALEAASSVASAYDELGSDSEEDFDWREALSTLCLQPRALPGEPQTQPTQAPGSDQGPSASSGPSPNPEAMWSDSETSSVGSSREAGHRARLSWLQRKAPRNPAAEKMRLQGELDVNFNLQAAGRETSDSSEPEEAPHAADRRARRWRRARGCSEELSKELPSPSGHPPELDTHQVPGGLSETDTSSEARHPRASTDTTEEKRRNRLYELARKMSEKETSSGEDQESEPKTESENRKESLSSEDNSQSVQEELKKVYLAAGTVYGLEGQLSELEDAARCIHSGTDETELADLEDQVATAAAQVHHAEIQISDIESRISALTNAGLNIAPCGRLTRKRNQKQRNQVQTIDTSRHQRRKLPAPPVKAEKIEASSTATIKTFNRNFILQDSSTNGTKERNSTPKDLIEPTLESAVMC", "length": 789, "header": "tr|F1MET5-1|A0A3Q1LSJ3_BOVIN Computationally mapped isoform of Myosin VIIA and Rab interacting protein OS=Bos taurus OX=9913 GN=MYRIP PE=4 SV=4 CANONICAL=A0A3Q1LSJ3-1" }, "locus": { "chromosome": "22", "start_pos": 13148131, "end_pos": 12954886, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012409.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012409.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012409.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012409.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522113", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522113", "resource": "KEGG Pathway" }, { "id": "R-BTA-9824585", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9824585", "resource": "Reactome", "description": "Regulation of MITF-M-dependent genes involved in pigmentation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z0M6-1", "protein_name": "Myelin associated oligodendrocyte basic protein", "gene_name": "MOBP", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGRKLDLSGLTDEEAEHVLQVVQRDFSLRKKEEERLSEMKQKLDEEGNKCSILSKQQKFNEHCCIRCCSPFTFLINSKRQCQDCKYNICKSCSSYQKKEKAWICSVCQQARLLRTQSLDWYYNNVKSRFKCFGSAKVLKNLYKKHRLESGVCPDVIEGGCFEGSFENDGSICGSDSTFYRETEGHSMMDTLAVALRVAEEAVEEAISKAETYSDSLDKQNEACYLQEHKEDLIEELATTIVQKIIKKQKGKTEQAEADFEWPPSRSSGLASVAVSDQSMLTFPGSRRGSYTLWRSQSAFSLASEDAPSKGLDPASSVTEALWRQQKGQFKKQKERKLSALPSWKSVDRLNETNPPPVLQSTDGNWVALQNISLPRPRMLAKPKSQVFEALENESSVVSAYDEMGSDSEDDYDWNVALNKLRRRPRQLPDDFYCTNSQYDSQWAYGNDQYQAVTSPSSGLYTNTETLFSDSETSSVNSSQEAKGPSKLLWLQSRTQSDVPRMEKKHFHGELDVNFNPQATSLEYSDSSETEEVQYDLEKRSRRWRKNKTISEESCEGKNHTKANVKNLSQDLDDLSETDGSSEDQHHNIKPELMEEELKSRLFQLAAKMSDKETSSGEEQESEPRTDPENQKESLSSEENGKSIQEELKKEKQKAFDLHIKLQFLSTVLQQKYSAVSLCNISTEVLKVINATEELIAESGSPCDFPDDVQDKGRGTFPLGTDPIRLDEQLTTLEENVYLTASTVYGLEGQLTTLEDAARQISSVTAESELAELEDQVATAAAQVHHAELQISDIESRISALTVAGLNVAPCVRLTRKRDQKQTNQMHTIDTSRQQRRKLPAPPVKGEKMDGSPITTVRTFNRNFMLQGSLTQRTKERKSTAKDLMEPAIGSAVMY", "length": 894 }, "evidence": [ { "id": "A0A3Q1LSJ3", "url": "https://omabrowser.org/oma/group/A0A3Q1LSJ3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7K8U6-1", "protein_name": "Rab effector MyRIP isoform X2", "gene_name": "Myrip", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSEMKQRLAEENSKCSILSKHQKFVERCCMRCCSPFTFLVNARRRCGECKFSVCKSCCSYQKREKLWVCCVCQQARLLRTQSLEWFYSNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGGPFEPNLENEGSISGSDSAFYRQSEGHSMMDTLAVALRVAEEAIEEAISKAESHGDSLDKQNEASYLRDHKEELTEELATTILQRIIRKQKNKAEPPAEEEGPEWPRPQSGGVKAEDEGTMAPPGRQRAHTTLWRSQSAFSFTTDDALKTCSAEATPRRSRERGQHLLEESALPGWKSMDGLDGTILAPVLQSPDGNWMALKDDGTRPPSRLLVKPKSGTFQALEVASSVTSAYDEMGSDSEEDFDYSEALSKLCPLPQGRSKQSQSQPAQAQCSGQGPLATSPSNPEAMGSDSETSSSSREAGRRARLSWPQRKAPKTPTAEKTRHQGELDVNFNPQAASGETSDSSDPEEAPHTADRWARRWRRARVGQEEPNRGLSSPSAHPQGLHTPQVSDNVSETDISNEAQNSRTSTDSAEEKLRNRLYELAMKMSETATSSGEDQESEPKTEPETQKESLSCEETSQGVQEELKKKCSAVSLCNISTEVLKVINATEELIAESAGPWEIPPVPTDRDMSMFPLGTDQVRLDKQLTSLEENVYLAAGTVYGLEGQLSELEDAARCIHSSTGETELADLEDQVAAAAAQVHHAELQISDIESRISALTIAGLNIAPCVRLTRRRHQKQRNQVQTIDTSRQQRRKLPAPPVKAEKIEASSVTPIKAFNRNFLLQGSSENRPSEKQGDTKDVMEPVLESAVIH", "length": 854 }, "evidence": [ { "id": "A0A3Q1LSJ3", "url": "https://omabrowser.org/oma/group/A0A3Q1LSJ3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A8T6P4-1", "protein_name": "Rab effector MyRIP", "gene_name": "myrip", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGRKLDLSGLSNNEAEHVLRVVQRDMQLRKKEEERLSEMKQELEEEGSRCLLLSKQQKFNEHCCIRCCSPFTFLLNPKRQCLDCHYNICKSCCSYSQSERGYICAACQKSRHLRTQSLEWFYNNVKSRFKRFGSAKVLKTLYRKHIIERGALSELPEVSAHEGSNDNGSICDGSDSTLYKQSEGHSMADTLTVALRVAEEAIEEAIAKAENYKDSLEKQNEARYLHEHKEELIEELATTIVQKIIQRGKRPEIQEEYEFVWPQNQKSELPSPTSTQNPLATQNSHSTSQPGAVAQSDISKRSRSAYSSDDSPEKGPEVGMAPGVPKSTEVETDIQNYSSLRRESRALSLPGWKSVDRLENSSASSVLQSPDGNWIALQSSQHSRPSLLTKRKSLVFSVLEKESGVVSAYDEMGSDSDPEDQGGWGAALLQFRRRLSDETYYTDSQHDPEWTFTQHPPITSPSSGQYTNTETLNSDSETSPSPSTRARRAPVMKKGPPETHLYPYYRHPADIVALPQLKPDVLDVNFNPHLGGDSSDGEERSEQVKRSRRRRKSKRETSEHSRAHNALYSAATAENSTVLLNAMMMRRQQSQENTVPLNHQTPDSVTSPDILTFNNMSPEPEYQNTLAHNSSAASLPLLSQLGSNNPGFAPQDPLLRAFPVNETLEEELKYKLSELIGQVSERDVKSSDFEPISEVGNKQEDRVSEKDSGKLRPKERRESKRESKLREMEKQSERQTVKLMDTSDAVRQINIERQMKKERERQRDIERQVERERERQRELEKQIEKDRERRREIEMQVEKKQERQKEMEKQLKQEQERQSEIERDLEKKRKSIRMEKRN", "length": 838 }, "evidence": [ { "id": "A0A3Q1LSJ3", "url": "https://omabrowser.org/oma/group/A0A3Q1LSJ3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7TNY7-1", "protein_name": "Rab effector MyRIP", "gene_name": "Myrip", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEDRLSEMKQRLAEENSKCSILSKHQKFVERCCMRCCSPFTFLVNARRRCGECKFSVCKSCCSYQKHEKLWVCCVCQQARLLRTQSLEWFYNNVKTRFKRFGSAKVLKNLYKKHRLESGACFDILGGGLYEPNLENEGSISGSDSTFYRQSEGHSMMDTLAVALQVAEEAIEEAISKAESQRDSLDKQNEASYLRDHRQELAEELAGTILQRIIRKQKDKADLHAEEEEPECTRPQSSGVKARGEGTAAPPGRHKARAALWRSQSAFSFTTEDTLKTSSAEAAPRQPKDRAQRLLEESALPSWRSMDGLDGKNLVPLLQSPDGNWMTLKDSSRQPPTRLLAKPKSRTFQALEVASSVASAYDELGSDSEEDFDYSEALSKLRPPSQGRLKQPQPQPAQAQSSGQGPLATSPSNPEAMCSDSETSSTSSSREAGCRAKLLWLQRKAPKNPSAEKTHLQGELDVNFNPQAAGGETSDSSDPEETLHTADRRARRWRRARVGPEESNRGLPSPSAYPPALHTAQVSDNVSETDISNEAQNSRSSTDSAEEKLRNRLYELAMKMSEKETSSGEDQESESKTEPKNQKGSLSSEENNQGVQEELKKKCSAVSLCNISTEVLKVINATEELIAESAGPWEIPPVSTDRDNGMFPLGTDQRSLDKQLTSLEENVYLAAGTVYGLEGQLSELEDAARCIHSSTGETELADLEDQVAAAAAQVHHAELQISDIESRISALTIAGLNIAPCVRLTRRRDQKQRSQVQTIDTSRQQRRKLPAPPVKAEKIEASSVTPIKTFNRNFLLQGSSTNRPTASTSNTKDLMEPVLESAVMY", "length": 856 }, "evidence": [ { "id": "A0A3Q1LSJ3", "url": "https://omabrowser.org/oma/group/A0A3Q1LSJ3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8K3I4-1", "protein_name": "Rab effector MyRIP", "gene_name": "Myrip", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEDRLSEMKQRLAEENSKCSILSKHQKFVERCCMRCCSPFTFLVNARRRCGECKFSVCKSCCSYQKHEKLWVCCVCQQARLLRTQSLEWFYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGGLFEPNLENEGSISGSDSTFYRQSEGHSMMDTLAVALRVAEEAIEEAISKAESHGDSLDKQNEASYLRDHKQELTEELAGTILQRIIRKQKDKAELRAEEEEPEWPRSQSGSVKARGEGTTAPPGRHKARATFRRSQSAFSFTMEDALKSGSAEAAPRSPKDRAQRLLEEAALPSWRSMDGLDGTNLAPLLQSPDGNWMTLKDGSRQPPTRLLTKPKSGTFQALEVASSVTSAYDEIGSDSEEDFDYSEALSKLCPPSQSRLKQPQPQPTQAQSSGQGPLATSPSNPEAMCSDSETSSTSSSREAGCRAKLSWLQRKAPKNPAVEKMPLQGELDVNFNPQAAGGETSDSSDPEETLRTAERRARRWRRARVGPEESNRGLPSPGAHPRALHTAQVSDNVSETDISNETQNSRSSTDSVEEKLRNRLYELAMKMSEKETSSGEDQESESKAEPKNQKGSLSSEENNQGVQEELKKKCSAVSLCNISTEVLKVINATEELIAESAGPWEIPPVSTDRENGMFPLGTDQVRLDKQLTSLEENVYLAAGTVYGLEGQLSELEDAARCIHSSTGETELADLEDQVAAAAAQVHHAELQISDIESRISALTIAGLNIAPCVRLTRRRDQKQRSQVQTIDTSRQQRRKLPAPPVKAEKIEASSVTPIKTFNRNFLLQGSSTNRPTASTGDTKDLMEPDLESAVMY", "length": 856 }, "evidence": [ { "id": "A0A3Q1LSJ3", "url": "https://omabrowser.org/oma/group/A0A3Q1LSJ3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NFW9-1", "protein_name": "Rab effector MyRIP", "gene_name": "MYRIP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFVEHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEWFYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGSLFESNLENEGSISGSDSTFYRQSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTILQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSITGEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQKESLSSEDNSQSVQEELKKKFSAVSLCNISTEVLKVINATEELIAGSTGPWESPQVPPDRQKGMFPRGTDQVRLDEQLTSLEENVYLAAGTVYGLETQLTELEDAARCIHSGTDETHLADLEDQVATAAAQVHHAELQISDIESRISALTIAGLNIAPCVRFTRRRDQKQRTQVQTIDTSRQQRRKLPAPPVKAEKIETSSVTTIKTFNHNFILQGSSTNRTKERKGTTKDLMEPALESAVMY", "length": 859 }, "evidence": [ { "id": "A0A3Q1LSJ3", "url": "https://omabrowser.org/oma/group/A0A3Q1LSJ3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" } ], "pmid": "" }, { "name": "myosin binding", "id": "GO:0017022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017022", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" } ], "pmid": "" }, { "name": "protein kinase A binding", "id": "GO:0051018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051018", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" } ], "pmid": "" }, { "name": "melanosome", "id": "GO:0042470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042470", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" } ], "pmid": "" }, { "name": "cortical actin cytoskeleton", "id": "GO:0030864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030864", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" } ], "pmid": "" }, { "name": "photoreceptor outer segment", "id": "GO:0001750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001750", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" } ], "pmid": "" }, { "name": "exocyst", "id": "GO:0000145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000145", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 639, "end_pos": 641, "annotation": "n_glycosylation_sequon" }, { "start_pos": 649, "end_pos": 651, "annotation": "n_glycosylation_sequon" }, { "start_pos": 831, "end_pos": 833, "annotation": "n_glycosylation_sequon" }, { "start_pos": 837, "end_pos": 839, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LSJ3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 854, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LSJ3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LSJ3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LSJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSJ3" }, { "id": "PS50916", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50916" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RabBD", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 124, "start_aa": "Lys", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 639, "end_pos": 641 }, { "start_pos": 649, "end_pos": 651 }, { "start_pos": 831, "end_pos": 833 }, { "start_pos": 837, "end_pos": 839 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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taurus OX=9913 GN=KRTAP27-1 PE=3 SV=2 CANONICAL=A0A3Q1LSL9-1" }, "locus": { "chromosome": "1", "start_pos": 5633252, "end_pos": 5632723, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080742.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080742.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063375.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063375.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 200, "start_aa": "Thr", "end_pos": 200, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr200", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": 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"header": "tr|A0A3Q1LSM0-1|A0A3Q1LSM0_BOVIN Isoform 1 of CD1a molecule OS=Bos taurus OX=9913 GN=CD1A PE=4 SV=2 CANONICAL=A0A3Q1LSM0-1" }, "locus": { "chromosome": "3", "start_pos": 11862627, "end_pos": 11859726, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066846.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066846.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060255.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060255.2" } ] } }, { "isoform_ac": "A0A3Q1LTU4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTU4/entry", "sequence": { "sequence": "MLFLQLPLLLALLVGGDNEQNKNSVPEGFQEPISFEVICVLSFHNSSWVQSLGSGWLGELQTHGWKSNSGTFIYLWPWSKGNFSNEELMELQNYLHTNFVRFVQAFYSHARKWQFEYPFEVQIAEGCELHAGEVPVGFMRIAYQGSDFLSFQNKSWVSSPEGGKRAQVLRRLFNLFRGAQEIIHKLLSDTCPRFLLGLLDAGKAYLQRPDHHSSMGWIALAVIVTLVLMAGLAFWLWKHWTHRESPSSVLPLE", "length": 253, "header": "tr|A0A3Q1LTU4-1|A0A3Q1LSM0_BOVIN Computationally mapped isoform of CD1a molecule OS=Bos taurus OX=9913 GN=CD1A PE=4 SV=1 CANONICAL=A0A3Q1LSM0-1" }, "locus": { "chromosome": "3", "start_pos": 11862627, "end_pos": 11859726, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082417.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082417.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063905.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063905.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSM0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSM0" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { 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"MGLSRVWLFLDGLAFFVLLGNAAGSHSLCYNITVLSQDGSVQASSFAEGYLDRQTFLHYDHKKGRAEPWGEWAEKLAAETWETESTDLNESWKELRKLLAEILSLQKEKGGLHSLQETVGCSINEDSHPRGFRLLYFNGELLLSCYPEPHGCTLPQSSARTLAMEMELSKHYQAHVQGELCRRLRSYLESWLGFTERTELPAVNVTYSQDSEGMVHLTGKAFGFFPRSISVVWFRDEEPMSWNDQESGDVLSDGNGTYYTWETVKIPQGEEQWVKCIVEHSRNHSSHLAPLGKTLAHQSSWWIVSVSVAVVFIIGFCVYCYIKKRKTASATGRPEPIRLQDLEQFQTEPTDHNGLTHPEFQSLCHTPAPSV", "length": 371, "header": "tr|A0A3Q1LSQ1-1|A0A3Q1LSQ1_BOVIN Isoform 1 of Immunoglobulin C1-set domain-containing protein OS=Bos taurus OX=9913 GN=LOC112443864 PE=3 SV=2 CANONICAL=A0A3Q1LSQ1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSQ1/entry", "sequence": { "sequence": "MGLSRVWLFLDGLAFFVLLGNAAGSHSLCYNITVLSQDGSVQASSFAEGYLDRQTFLHYDHKKGRAEPWGEWAEKLAAETWETESTDLNESWKELRKLLAEILSLQKEKGGLHSLQETVGCSINEDSHPRGFRLLYFNGELLLSCYPEPHGCTLPQSSARTLAMEMELSKHYQAHVQGELCRRLRSYLESWLGFTERTELPAVNVTYSQDSEGMVHLTGKAFGFFPRSISVVWFRDEEPMSWNDQESGDVLSDGNGTYYTWETVKIPQGEEQWVKCIVEHSRNHSSHLAPLGKTLAHQSSWWIVSVSVAVVFIIGFCVYCYIKKRKTASATGRPEPIRLQDLEQFQTEPTDHNGLTHPEFQSLCHTPAPSV", "length": 371, "header": "tr|A0A3Q1LSQ1-1|A0A3Q1LSQ1_BOVIN Isoform 1 of Immunoglobulin C1-set domain-containing protein OS=Bos taurus OX=9913 GN=LOC112443864 PE=3 SV=2 CANONICAL=A0A3Q1LSQ1-1" }, "locus": { "chromosome": "23", "start_pos": 27961163, "end_pos": 27954336, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086060.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086060.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060296.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060296.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], 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"database": "Ensembl Peptide", "id": "ENSBTAP00000063539.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063539.2" } ] } }, { "isoform_ac": "F1MEW4-1", "url": "https://www.uniprot.org/uniprotkb/F1MEW4/entry", "sequence": { "sequence": "MPFETSPADTLCRSAGCPHLSGAHLGRGSLEKEPPEDKEAKELLWIRPDAPSRCSWQLGRPVADSPHCHAALVKSPKILPDILKKIGDTPMVRINKIGRNFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAEREGTIKPGDTIIEPTSGNTGIGLALAAAVKGYRCIIVMPEKMSTEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLRNEIPNSHILDQYRNASNPLAHYDITAEEILQQCDGRLDMLVASAGTGGTITGVARKLKEKCPGCKIVGVDPEGSILAEPEELNQTEQTAYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFAFARMLIAQEGLLCGGSSGSAMSVAVKAAQELQEGQRCVVILPDSVRNYMSKFLSDKWMLQKGFMKEEEISVKRPWWWHLQVQELSLSAPLTVLPTVTCEHTIEILREKGFDQAPVVDESGVILGMVTLGNMLSSLLAGKVQPSDQVCKVIYKQFKQIYLTDPLGKLSHILEMDHFALVVHEQIQSRDLALSGEVGGPADRCHGESSKRQMVFGVVTAIDLLNFVATRERNQRTKPESALKLGGVGAEAQL", "length": 585, "header": "tr|F1MEW4-1|F1MEW4_BOVIN Computationally mapped isoform of Cystathionine beta-synthase OS=Bos taurus OX=9913 GN=CBS PE=3 SV=2 CANONICAL=A0A3Q1LSY7-1" }, "locus": { "chromosome": "1", "start_pos": 143238915, "end_pos": 143220192, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000184.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000184.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000184.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000184.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 25, "start_aa": "Thr", "end_pos": 25, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr25", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1614603", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614603", "resource": "Reactome", "description": "Cysteine formation from homocysteine" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 12, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "cystathionine beta-synthase activity", "id": "GO:0004122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004122", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "oxygen binding", "id": "GO:0019825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019825", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "nitrite reductase (NO-forming) activity", "id": "GO:0050421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050421", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "carbon monoxide binding", "id": "GO:0070025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070025", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "nitric oxide binding", "id": "GO:0070026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070026", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "modified amino acid binding", "id": "GO:0072341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072341", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "S-adenosyl-L-methionine binding", "id": "GO:1904047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904047", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "DNA protection", "id": "GO:0042262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042262", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "homocysteine catabolic process", "id": "GO:0043418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043418", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "cysteine biosynthetic process from serine", "id": "GO:0006535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006535", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "L-serine catabolic process", "id": "GO:0006565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006565", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "cysteine biosynthetic process via cystathionine", "id": "GO:0019343", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019343", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "L-cysteine catabolic process", "id": "GO:0019448", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019448", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "hydrogen sulfide biosynthetic process", "id": "GO:0070814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070814", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" }, { "name": "homocysteine metabolic process", "id": "GO:0050667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050667", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LSY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10112", "name": "", "equation": "L-homocysteine + L-serine = L,L-cystathionine + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LSY7-1" ], "evidence": [ { "id": "10112", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10112" } ] }, { "id": "R-BTA-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-174369", "R-ALL-200736" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LSY7-1" ], "evidence": [ { "id": "R-BTA-1614524", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614524" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-174369", "participant_name": "HCYS [cytosol]", "crossref": [ { "id": "58199", "database": "ChEBI", "url": "" }, { "id": "ZINC000000895077", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-200736", "participant_name": "L-Ser [cytosol]", "crossref": [ { "id": "33384", "database": "ChEBI", "url": "" }, { "id": "ZINC000000895034", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LSY7", "gene_name": "CBS", "activity": [ { "ec_number": "4.2.1.22", "activity": "L-homocysteine + L-serine = L,L-cystathionine + H2O.", "evidence": [ { "id": "A0A3Q1LSY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ] }, { "ec_number": "4.2.1.22", "activity": "", "evidence": [ { "id": "A0A3Q1LSY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LSY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSY7" }, { "id": "PS51371", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51371" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CBS", "eco_id": "ECO_0000259", "start_pos": 445, "end_pos": 503, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.2.1.22", "ec_name": "L-homocysteine + L-serine = L,L-cystathionine + H2O.", "evidence": [ { "id": "4.2.1.22", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.22" }, { "id": "4.2.1.22", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.22" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 25 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 252, "end_pos": 254 }, { "start_pos": 321, "end_pos": 323 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": 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"evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086832.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086832.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058242.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058242.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT19", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT19" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT19", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT19" } ], "pmid": "" }, { "name": "MHC class 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"pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LT19-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 106, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LT19-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LT19" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LT19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT19" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 103, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LT21-1", "uniprot_ac": "A0A3Q1LT21", "uniprot_id": "A0A3Q1LT21_BOVIN", "mass": { "chemical_mass": 164800.0, "monoisotopic_mass": 164800.0 }, "refseq": {}, "gene_names": [ { "name": "PRTG", "type": "recommended", "evidence": [ { "id": "A0A3Q1LT21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21" } ] }, { "name": "PYGO1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LT21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21" } ] }, { "name": "PRTG", "type": "synonym", "evidence": [ { "id": "A0A3Q1LT21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21" } ] } ], "protein_names": [ { "name": "Protogenin", "type": "recommended", "evidence": [ { "id": "A0A3Q1LT21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21/entry#names_and_taxonomy" } ] }, { "name": "Protein Shen-Dan", "type": "synonym", "evidence": [ { "id": "A0A3Q1LT21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in signal transduction through the Wnt pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SXU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXU8#function" }, { "database": "UniProtKB", "id": "ARBA00037400", "url": "https://www.uniprot.org/uniprotkb/ARBA00037400#function" }, { "database": "UniProtKB", "id": "A0AAA9SRM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRM2#function" }, { "database": "UniProtKB", "id": "A0AAA9U0S5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0S5#function" }, { "database": "UniProtKB", "id": "F1MHP8", "url": "https://www.uniprot.org/uniprotkb/F1MHP8#function" }, { "database": "UniProtKB", "id": "A0A3Q1LT21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21#function" } ] }, { "annotation": "May play a role in anteroposterior axis elongation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21#function" }, { "database": "UniProtKB", "id": "ARBA00002140", "url": "https://www.uniprot.org/uniprotkb/ARBA00002140#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRTG", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21", "locus": {} } ], "crossref": [ { "id": "A0A3Q1LT21", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LT21", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005848", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005848", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000009151", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009151", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15635", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15635", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527394", "url": "https://www.ncbi.nlm.nih.gov/gene/527394", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527394", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527394", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CTHEVND", "url": "https://omabrowser.org/oma/group/CTHEVND/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LT21", "url": "https://www.orthodb.org/?gene=A0A3Q1LT21", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MHP8", "url": "https://www.orthodb.org/?gene=F1MHP8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23194", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23194", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23194:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23194:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44170", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44170", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44170:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44170:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27108", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27108", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-201722", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201722", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LT21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LT21-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRM2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRM2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRM2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0S5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0S5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0S5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0S5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHP8", "url": "https://www.uniprot.org/uniprotkb/F1MHP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHP8-1", "url": "https://www.uniprot.org/uniprotkb/F1MHP8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPSLRPLARPRPPGMLLGALLLLPLLGRVPGVWCFSELVFIKEPQDITVTRKDPVVLDCQAHGEVPIKVTWLKNGAKVSENKRIQVLSNGSLYISEVEGKRGEQYDEGFYQCLAMNRHGAILSQKAHLTLSTISAFEVQPISIEVREGGVARFACKISSNPPAAITWELNRTTLSVTMDSDRITALPTGVLQIYDVDQRDAGNYRCVAATIAHRRKSMEASLTVIPGKESKSFHTPTIVAGPQNITTSLHQTVVLECVATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDIRLQHAGVYVCRATTPGTRNFTVATATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVIQNTLEDVPLRPPEISLTSRSPTDILVSWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEHLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVKWQQDAEDTATIQGYKLYYKEEGQQEHGPIFLDTSGLLYTLSGLDPRRKYHVRLLAYNSIEDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTTAQMINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWRPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNIYIVKISASNEVGEGPFSNSVELAVLPKETPESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICGLILIYRSKARKSTVSKTGQNGTQQLPRISASRASGNEVGKNLEGAIENEESLMPMIMPNSFIDAKGGTDLIINSYGPIIKNTPKKKWLFFQDSKKIKAEQPQRRFTQAVCLYQPGTTILISDEDSPSSPGGDSGLDGLGGPGVQLGSPDKKKRKTNTQGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALTQNVNMPNQHFRQNPAENFNQIPPQNASQVSNPDLASNFVPASNSNFSSPLESNHSFIPPPNTFGQAKAPPPKQDFSQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNVVSQENSRSSSTEATNNSHANGTQSKPRQPRGATDTCTTEKSNKSALHPSRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPPAVGSDG", "length": 1500, "header": "tr|A0A3Q1LT21-1|A0A3Q1LT21_BOVIN Isoform 1 of Protogenin OS=Bos taurus OX=9913 GN=PRTG PE=3 SV=2 CANONICAL=A0A3Q1LT21-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LT21-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21/entry", "sequence": { "sequence": "MAPSLRPLARPRPPGMLLGALLLLPLLGRVPGVWCFSELVFIKEPQDITVTRKDPVVLDCQAHGEVPIKVTWLKNGAKVSENKRIQVLSNGSLYISEVEGKRGEQYDEGFYQCLAMNRHGAILSQKAHLTLSTISAFEVQPISIEVREGGVARFACKISSNPPAAITWELNRTTLSVTMDSDRITALPTGVLQIYDVDQRDAGNYRCVAATIAHRRKSMEASLTVIPGKESKSFHTPTIVAGPQNITTSLHQTVVLECVATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDIRLQHAGVYVCRATTPGTRNFTVATATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVIQNTLEDVPLRPPEISLTSRSPTDILVSWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEHLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVKWQQDAEDTATIQGYKLYYKEEGQQEHGPIFLDTSGLLYTLSGLDPRRKYHVRLLAYNSIEDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTTAQMINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWRPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNIYIVKISASNEVGEGPFSNSVELAVLPKETPESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICGLILIYRSKARKSTVSKTGQNGTQQLPRISASRASGNEVGKNLEGAIENEESLMPMIMPNSFIDAKGGTDLIINSYGPIIKNTPKKKWLFFQDSKKIKAEQPQRRFTQAVCLYQPGTTILISDEDSPSSPGGDSGLDGLGGPGVQLGSPDKKKRKTNTQGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALTQNVNMPNQHFRQNPAENFNQIPPQNASQVSNPDLASNFVPASNSNFSSPLESNHSFIPPPNTFGQAKAPPPKQDFSQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNVVSQENSRSSSTEATNNSHANGTQSKPRQPRGATDTCTTEKSNKSALHPSRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPPAVGSDG", "length": 1500, "header": "tr|A0A3Q1LT21-1|A0A3Q1LT21_BOVIN Isoform 1 of Protogenin OS=Bos taurus OX=9913 GN=PRTG PE=3 SV=2 CANONICAL=A0A3Q1LT21-1" }, "locus": { "chromosome": "10", "start_pos": 54830801, "end_pos": 54636251, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087201.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087201.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060181.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060181.2" } ] } }, { "isoform_ac": "A0AAA9SRM2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRM2/entry", "sequence": { "sequence": "MQLIFLRKGETIFIENAFLYWLVDKKQVAPNQFYTRSVGWLLPRTRVRNFPAALLRNIRGNVCQTKDTACGDSGLDGLGGPGVQLGSPDKKKRKTNTQGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALTQNVNMPNQHFRQNPAENFNQIPPQNASQVSNPDLASNFVPASNSNFSSPLESNHSFIPPPNTFGQAKAPPPKQDFSQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNVVSQENSRSSSTEATNNSHANGTQSKPRQPRGATDTCTTEKSNKSALHPSRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPPAVGSDG", "length": 472, "header": "tr|A0AAA9SRM2-1|A0A3Q1LT21_BOVIN Computationally mapped isoform of Protogenin OS=Bos taurus OX=9913 GN=PRTG PE=3 SV=1 CANONICAL=A0A3Q1LT21-1" }, "locus": { "chromosome": "10", "start_pos": 54830801, "end_pos": 54811199, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100869.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100869.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086712.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086712.1" } ] } }, { "isoform_ac": "A0AAA9SXU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXU8/entry", "sequence": { "sequence": "MSAEQEKDPISLKRVRGGDSGLDGLGGPGVQLGSPDKKKRKTNTQGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALTQNVNMPNQHFRQNPAENFNQIPPQNASQVSNPDLASNFVPASNSNFSSPLESNHSFIPPPNTFGQAKAPPPKQDFSQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNVVSQENSRSSSTEATNNSHANGTQSKPRQPRGATDTCTTEKSNKSALHPSRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPPAVGSDG", "length": 419, "header": "tr|A0AAA9SXU8-1|A0A3Q1LT21_BOVIN Computationally mapped isoform of Protogenin OS=Bos taurus OX=9913 GN=PRTG PE=3 SV=1 CANONICAL=A0A3Q1LT21-1" }, "locus": { "chromosome": "10", "start_pos": 54830801, "end_pos": 54810672, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135022.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135022.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090190.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090190.1" } ] } }, { "isoform_ac": "A0AAA9U0S5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0S5/entry", "sequence": { "sequence": "MSNGGDSGLDGLGGPGVQLGSPDKKKRKTNTQGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALTQNVNMPNQHFRQNPAENFNQIPPQNASQVSNPDLASNFVPASNSNFSSPLESNHSFIPPPNTFGQAKAPPPKQDFSQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNVVSQENSRSSSTEATNNSHANGTQSKPRQPRGATDTCTTEKSNKSALHPSRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPPAVGSDG", "length": 406, "header": "tr|A0AAA9U0S5-1|A0A3Q1LT21_BOVIN Computationally mapped isoform of Protogenin OS=Bos taurus OX=9913 GN=PRTG PE=3 SV=1 CANONICAL=A0A3Q1LT21-1" }, "locus": { "chromosome": "10", "start_pos": 54830801, "end_pos": 54811676, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108052.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108052.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103275.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103275.1" } ] } }, { "isoform_ac": "F1MHP8-1", "url": "https://www.uniprot.org/uniprotkb/F1MHP8/entry", "sequence": { "sequence": "MSAEQEKDPISLKRVRGGDSGLDGLGGPGVQLGSPDKKKRKTNTQGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALTQNVNMPNQHFRQNPAENFNQIPPQNASQVSNPDLASNFVPASNSNFSSPLESNHSFIPPPNTFGQAKAPPPKQDFSQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNVVSQENSRSSSTEATNNSHANGTQSKPRQPRGATDTCTTEKSNKSALHPSRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDT", "length": 394, "header": "tr|F1MHP8-1|F1MHP8_BOVIN Computationally mapped isoform of Pygopus family PHD finger 1 OS=Bos taurus OX=9913 GN=PYGO1 PE=4 SV=3 CANONICAL=A0A3Q1LT21-1" }, "locus": { "chromosome": "10", "start_pos": 54830727, "end_pos": 54810672, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012057.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012057.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012057.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012057.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527394", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527394", "resource": "KEGG Pathway" }, { "id": "R-BTA-201722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201722", "resource": "Reactome", "description": "Formation of the beta-catenin:TCF transactivating complex" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QDU6-1", "protein_name": "Pygopus family PHD finger 1", "gene_name": "PYGO1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "TPAKNSPAPAYKVCSDRGDSGLDGLGGPGVQLGSPDKKKRKTNTQGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNPAENFNQIPPQNASQVSNPDLASNFVPGNNSNFTSPLEPNHSFIPPPNTFGQAKPPPQKQDFSQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNVVNQENSRSNSTEATNNSHANGTQNKPRQPRGATDTCTTEKSNKSSLHPSRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGAPAVGSDT", "length": 419 }, "evidence": [ { "id": "A0A3Q1LT21", "url": "https://omabrowser.org/oma/group/A0A3Q1LT21/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6AA06-1", "protein_name": "Pygopus family PHD finger 1", "gene_name": "Pygo1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAEQDKEPIALKRVRGGDSGLDGLGGPNIQLGSPDKKKRKASTQGASFPPLSEYAPPPNPNADHLVAANPFDDSYNTISYKPLPSSNPYLSPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYALRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSNFGNPPYNNVLTQDINMPSQHFRQGSAENFSQIPPQNVGQVSNPDLASNFAPGNNSNFNSPLESNHSFIPPPNSFGQAKAPLPKQDFTQGAAKTTNQNSSTHPPHLNMEDPVNQSNVELKNVNRNNVVQENSRSGSAEPTNNHANGTQNKPRQPRGTADLCTTDKSRKFSLHPSRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTREAFGPPAVGSDA", "length": 417 }, "evidence": [ { "id": "A0A3Q1LT21", "url": "https://omabrowser.org/oma/group/A0A3Q1LT21/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1BWE1-1", "protein_name": "Pygopus family PHD finger 1", "gene_name": "PYGO1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAEQEKDPIALKRSRGGDGGLDGLGGPGVQLGSPDKKKRKANTQGSSFPPPSEYAPPPNPSSDHLVAANPFDDNYNTVSYKPLPSGNPYFSNPGYPGFGGYNTFRMPPHMLHRVSTPYGGSYSLRNQPHPLPQNPVGMGFSRPHSFSFGPHDSPGFGNQPPYSGGQINQNVNMPGQHFRPNPGENFGHSGQIPHPDVPSNFGPGNNSNFPNTQLESSHSFVPPPSTYNQTKSSAQKQDFSQAASKASSQNTAALQHHHRTEDIVSQGNNDLKNVTRNNVVNQDSSHSNSADNTNAGHSNGTQSKSRQPRSTAEGCNSEKSSKTPLHPSRHGHSSSEPVYPCGICTHEVNDDQDAILCEASCQKWFHRICTGMTESAYGLLTAEASAVWGCDTCMADKDVQLMRTRETAGPPALNTDG", "length": 418 }, "evidence": [ { "id": "A0A3Q1LT21", "url": "https://omabrowser.org/oma/group/A0A3Q1LT21/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9D0P5-1", "protein_name": "Pygopus homolog 1", "gene_name": "Pygo1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAEQDKEPIALKRVRGGDSGLDGLGGPNIQLGSPDKKKRKANTQGSSFPPLSEYAPPPNPNSDHLVAANPFDDSYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSNFGNPPYNNVLTQDINMPGQHFRQGSAENFSQIPPQNVGQVSNPDLASNFAPGNNSNFTSPLETNHSFIPPPNAFGQAKAPLPKQDFTQGATKTPNQNSSTHPPHLNMEDPVNQSNVELKNVNRNNVVQENSRSGSAEATNNHANGTQNKPRQPRGAADLCTPDKSRKFSLLPSRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTREAFGPPAVGGDA", "length": 417 }, "evidence": [ { "id": "A0A3Q1LT21", "url": "https://omabrowser.org/oma/group/A0A3Q1LT21/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y3Y4-1", "protein_name": "Pygopus homolog 1", "gene_name": "PYGO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPAENSPAPAYKVSSHGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNPAENFSQIPPQNASQVSNPDLASNFVPGNNSNFTSPLESNHSFIPPPNTFGQAKAPPPKQDFTQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNAVNQENSRSSSTEATNNNPANGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAVGSDA", "length": 419 }, "evidence": [ { "id": "A0A3Q1LT21", "url": "https://omabrowser.org/oma/group/A0A3Q1LT21/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": 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"Biological Process", "total": 5, "go_terms": [ { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21" } ], "pmid": "" }, { "name": "negative regulation of neurogenesis", "id": "GO:0050768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050768", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21" } ], "pmid": "" }, { "name": "kidney development", "id": "GO:0001822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001822", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21" } ], "pmid": "" }, { "name": "spermatid nucleus differentiation", "id": "GO:0007289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007289", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT21" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1234, "end_pos": 1236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1272, "end_pos": 1274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1292, "end_pos": 1294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1300, "end_pos": 1302, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1333, "end_pos": 1335, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1348, "end_pos": 1350, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1377, "end_pos": 1379, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1382, "end_pos": 1384, "annotation": 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"yes" } }, { "uniprot_canonical_ac": "A0A3Q1LT45-1", "uniprot_ac": "A0A3Q1LT45", "uniprot_id": "A0A3Q1LT45_BOVIN", "mass": { "chemical_mass": 14276.0, "monoisotopic_mass": 14276.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Non-histone chromosomal protein HMG-17", "type": "recommended", "evidence": [ { "id": "A0A3Q1LT45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT45/entry#names_and_taxonomy" } ] }, { "name": "High mobility group nucleosome-binding domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "A0A3Q1LT45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT45/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. 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"https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ], "protein_names": [ { "name": "RNA helicase", "type": "recommended", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.13", "type": "synonym", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80/entry#names_and_taxonomy" } ] }, { "name": "ATP-dependent RNA helicase FANCM", "type": "synonym", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. 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"https://www.uniprot.org/uniprotkb/A0A3Q1LT80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LT80-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWI8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWI8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MT39", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MT39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MT39-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MT39-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DLJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLX2", "url": "https://www.uniprot.org/uniprotkb/F1MLX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLX2-1", "url": "https://www.uniprot.org/uniprotkb/F1MLX2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGRQRTLFQTWGSKVSRSTGAPTCNSGTERPQSTGISRARFPAVAEAAGAAEVEPESDDDVLLVAVYEAERQLNLENGGFCTSAGALWIYPTNCPVRDYQLHIARTALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYRVMGIPQSHMAEMTGSTQAFTRKEIWSSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFRVLALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILPYSHERRVEKLVVPLGEELEAIQKAYIQILEAFASSLIQRNVLMRKDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRAKNELSRNADFMKLYDHLDSMFSHTRSTSTSGVSAIQKGGKDKKFCYSHPKLKKLEEVVVEHFKSWNARKTSDKKCDETRVMIFSSFRDSVQEIAEMLLPHQPIIRVMTFVGHASGKSMKGFTQKEQLEVVKQFRSGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRKRQGRIVVILAEGREERTYNQSQCNKRSIYKAISGNRQVLHFYQGSPRMVPDGVNPQLHKMFITHGVYEPEKPSRNLPRKSSIFSYRNGIKQSNSKDDWFLSEEEFKLWNRRYRLRDTDEIQQITLPQVQFLSLHNEENRPTEEPTVGIRQLSLSEWRLWQDHPLPTYQVDHSDRCHHFINIMQMIEGMRHEEGECSYESEIKSYLRMEDVSSASSALRNEYNSFADGTFTNNRKSSFANINHRKSVSMTESDEECTEIFKQIPIKSTKIPSLKKKASENLKKDQPKKENKDVVMEPLDTDDSPTTEHILQVDPRNGERVSDTGEVTATCAVSENGGNPSCGLLTDCQFTIKSTGSFTGSFFDSGYNSFSDEKSFSASLFLSFEGELDIAKTDDQFFHCHSLTKEVLANVERFLSHSPPPLSGLSDLENEISEGSALENLVFLPYSECLQNDKSTNLMACSAVNSQQNLKFITHLSEKTCIYGTTNDKISDEPSFCDSDKVHKDSKNEHLVSSNQIQINISPSKDFAEEKNHDVDNSDLPILHTAQDESLLLFEDVNTEFNDVSPPPLNSKCESLGISDRTAVSEMAPVSQFFISDELLLENDSEPQDQIVCDTNSWKSHEGLRGRHEGKLNNDENGFDCSKDLFSVTFDLGFCSTGSEDEVVDHASDTNNEILDDLPGRRLDIKQINSTNCVSNQAVMSGAHVDNSTSVTTTHPSSEDKQTPAFSCFSMNATKSKEFMSPSYSQFLLPVGDKVMSTPLSESNILNSFSEKRMEMAKKSGSNMGKVNLHSFKETLNSTFGDSGLSTGKYKSKKQINLHQACHSTEDEQLSTHESEDDEIFRRKSKKTKGNVLESPENQKNSEVDSPLQVVKKHRVPPNRLDLSSSDESDNFHKRDPQSEDFTDHKRNAKRSIKVQKRQNHLKLVARKFLDEEAELSQEDAEYVSSDENDESEGEQDSSLLDFLNDETQLSQAINDSEMRAVYMKSVRSPLMSNRYKMAHKKHNINIFSQIPEQDETYLEDSFCVDEEESCESQSSEEVCVDFNLITEDCDTNESKKYKTRRAVKLKQMKMRQNCARSKNKLSRIILLDDSSEEEKDVKDKQESRTVVNPSTVPPGSSLQSRDHSHPVDNQLLHQRQQTPPNLKVPDSDVSDFKPQSLTNTESASSLFTAVGAQEDCRKFPVQLKGASALQDSGTCVPCCSNSRPRLADTHASLRLPQEGHRTCILVDSREIVSGSEVVSSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSINKNKLIDQIQYLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLATLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNICETLQFYLSIPNISYITALNMCHQFSSVKKMTNSTPQEISMYAQVTHQKAEEIYRYIHYIFDMQMLPADLNQADLLTQGSNLSF", "length": 2042, "header": "tr|A0A3Q1LT80-1|A0A3Q1LT80_BOVIN Isoform 1 of RNA helicase OS=Bos taurus OX=9913 GN=FANCM PE=3 SV=2 CANONICAL=A0A3Q1LT80-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LT80-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80/entry", "sequence": { "sequence": "MSGRQRTLFQTWGSKVSRSTGAPTCNSGTERPQSTGISRARFPAVAEAAGAAEVEPESDDDVLLVAVYEAERQLNLENGGFCTSAGALWIYPTNCPVRDYQLHIARTALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYRVMGIPQSHMAEMTGSTQAFTRKEIWSSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFRVLALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILPYSHERRVEKLVVPLGEELEAIQKAYIQILEAFASSLIQRNVLMRKDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRAKNELSRNADFMKLYDHLDSMFSHTRSTSTSGVSAIQKGGKDKKFCYSHPKLKKLEEVVVEHFKSWNARKTSDKKCDETRVMIFSSFRDSVQEIAEMLLPHQPIIRVMTFVGHASGKSMKGFTQKEQLEVVKQFRSGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRKRQGRIVVILAEGREERTYNQSQCNKRSIYKAISGNRQVLHFYQGSPRMVPDGVNPQLHKMFITHGVYEPEKPSRNLPRKSSIFSYRNGIKQSNSKDDWFLSEEEFKLWNRRYRLRDTDEIQQITLPQVQFLSLHNEENRPTEEPTVGIRQLSLSEWRLWQDHPLPTYQVDHSDRCHHFINIMQMIEGMRHEEGECSYESEIKSYLRMEDVSSASSALRNEYNSFADGTFTNNRKSSFANINHRKSVSMTESDEECTEIFKQIPIKSTKIPSLKKKASENLKKDQPKKENKDVVMEPLDTDDSPTTEHILQVDPRNGERVSDTGEVTATCAVSENGGNPSCGLLTDCQFTIKSTGSFTGSFFDSGYNSFSDEKSFSASLFLSFEGELDIAKTDDQFFHCHSLTKEVLANVERFLSHSPPPLSGLSDLENEISEGSALENLVFLPYSECLQNDKSTNLMACSAVNSQQNLKFITHLSEKTCIYGTTNDKISDEPSFCDSDKVHKDSKNEHLVSSNQIQINISPSKDFAEEKNHDVDNSDLPILHTAQDESLLLFEDVNTEFNDVSPPPLNSKCESLGISDRTAVSEMAPVSQFFISDELLLENDSEPQDQIVCDTNSWKSHEGLRGRHEGKLNNDENGFDCSKDLFSVTFDLGFCSTGSEDEVVDHASDTNNEILDDLPGRRLDIKQINSTNCVSNQAVMSGAHVDNSTSVTTTHPSSEDKQTPAFSCFSMNATKSKEFMSPSYSQFLLPVGDKVMSTPLSESNILNSFSEKRMEMAKKSGSNMGKVNLHSFKETLNSTFGDSGLSTGKYKSKKQINLHQACHSTEDEQLSTHESEDDEIFRRKSKKTKGNVLESPENQKNSEVDSPLQVVKKHRVPPNRLDLSSSDESDNFHKRDPQSEDFTDHKRNAKRSIKVQKRQNHLKLVARKFLDEEAELSQEDAEYVSSDENDESEGEQDSSLLDFLNDETQLSQAINDSEMRAVYMKSVRSPLMSNRYKMAHKKHNINIFSQIPEQDETYLEDSFCVDEEESCESQSSEEVCVDFNLITEDCDTNESKKYKTRRAVKLKQMKMRQNCARSKNKLSRIILLDDSSEEEKDVKDKQESRTVVNPSTVPPGSSLQSRDHSHPVDNQLLHQRQQTPPNLKVPDSDVSDFKPQSLTNTESASSLFTAVGAQEDCRKFPVQLKGASALQDSGTCVPCCSNSRPRLADTHASLRLPQEGHRTCILVDSREIVSGSEVVSSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSINKNKLIDQIQYLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLATLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNICETLQFYLSIPNISYITALNMCHQFSSVKKMTNSTPQEISMYAQVTHQKAEEIYRYIHYIFDMQMLPADLNQADLLTQGSNLSF", "length": 2042, "header": "tr|A0A3Q1LT80-1|A0A3Q1LT80_BOVIN Isoform 1 of RNA helicase OS=Bos taurus OX=9913 GN=FANCM PE=3 SV=2 CANONICAL=A0A3Q1LT80-1" }, "locus": { "chromosome": "21", "start_pos": 54940016, "end_pos": 54856875, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082960.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082960.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060519.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060519.2" } ] } }, { "isoform_ac": "A0A3Q1LWI8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWI8/entry", "sequence": { "sequence": "MSGRQRTLFQTWGSKVSRSTGAPTCNSGTERPQSTGISRARFPAVAEAAGAAEVEPESDDDVLLVAVYEAERQLNLENGGFCTSAGALWIYPTNCPVRDYQLHIARTALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYRVMGIPQSHMAEMTGSTQAFTRKEIWSSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFRVLALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILPYSHERRVEKLVVPLGEELEAIQKAYIQILEAFASSLIQRNVLMRKDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRAKNELSRNADFMKLYDHLDSMFSHTRSTSTSGVSAIQKGGKDKKFCYSHPKLKKLEEVVVEHFKSWNARKTSDKKCDETRVMIFSSFRDSVQEIAEMLLPHQPIIRVMTFVGHASGKSMKGFTQKEQLEVVKQFRSGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRKRQGRIVVILAEGREERTYNQSQCNKRSIYKAISGNRQVLHFYQGSPRMVPDGVNPQLHKMFITHGVYEPEKPSRNLPRKSSIFSYRNGIKQSNSKDDWFLSEEEFKLWNRRYRLRDTDEIQQITLPQVQFLSLHNEENRPTEEPTVGIRQLSLSEWRLWQDHPLPTYQVDHSDRCHHFINIMQMIEGMRHEEGECSYESEIKSYLRMEDVSSASSALRNEYNSFADGTFTNNRKSSFANINHRKSVSMTESDEECTEIFKQIPIKSTKIPSLKKKASENLKKDQPKKENKDVVMEPLDTDDSPTTEHILQVDPRNGERVSDTGEVTATCAVSENGGNPSCGLLTDCQFTIKSTGSFTGSFFDSGYNSFSDEKSFSASLFLSFEGELDIAKTDDQFFHCHSLTKEVLANVERFLSHSPPPLSGLSDLENEISEGSALENLVFLPYSECLQNDKSTNLMACSAVNSQQNLKFITHLSEKTCIYGTTNDKISDEPSFCDSDKVHKDSKNEHLVSSNQIQINISPSKDFAEEKNHDVDNSDLPILHTAQDESLLLFEDVNTEFNDVSPPPLNSKCESLGISDRTAVSEMAPVSQFFISDELLLENDSEPQDQIVCDTNSWKSHEGLRGRHEGKLNNDENGFDCSKDLFSVTFDLGFCSTGSEDEVVDHASDTNNEILDDLPGRRLDIKQINSTNCVSNQAVMSGAHVDNSTSVTTTHPSSEDKQTPAFSCFSMNATKSKEFMSPSYSQFLLPVGDKVMSTPLSESNILNSFSEKRMEMAKKSGSNMGKVNLHSFKETLNSTFGDSGLSTGKYKSKKQINLHQACHSTEDEQLSTHESEDDEIFRRKSKKTKGNVLESPENQKNSEVDSPLQVVKKHRVPPNRLDLSSSDESDNFHKRDPQSEDFTDHKRNAKRSIKVQKRQNHLKLVARKFLDEEAELSQEDAEYVSSDENDESEGEQDSSLLDFLNDETQLSQAINDSEMRAVYMKSVRSPLMSNRYKMAHKKHNINIFSQIPEQDETYLEDSFCVDEEESCESQSSEEVCVDFNLITEDCDTNESKKYKTRRAVKLKQMKMRQNCARSKNKLSRIILLDDSSEEEKDVKDKQESRTVVNPSTVPPGSSLQSRDHSHPVDNQLLHQRQQTPPNLKVPDSDVSDFKPQSLTNTESASSLFTAVGAQEDCRKFPVQLKGASALQDSGTCVPCCSNSRPRLADTHASLRLPQEGHRTCILVDSREIVSGSEVVSSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSINKNKLIDQIQYLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLATLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNICETLQFYLSIPNISYITALNMCHQFSSVKKMTNSTPQEISMYAQVTHQKAEEIYRYIHYIFDMQMLPADLNQALKV", "length": 2034, "header": "tr|A0A3Q1LWI8-1|A0A3Q1LWI8_BOVIN Computationally mapped isoform of RNA helicase OS=Bos taurus OX=9913 GN=FANCM PE=3 SV=2 CANONICAL=A0A3Q1LT80-1" }, "locus": { "chromosome": "21", "start_pos": 54923481, "end_pos": 54856875, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087365.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087365.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059797.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059797.2" } ] } }, { "isoform_ac": "A0A3Q1MT39-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MT39/entry", "sequence": { "sequence": "MSGRQRTLFQTWGSKVSRSTGAPTCNSGTERPQSTGISRARFPAVAEAAGAAEVEPESDDDVLLVAVYEAERQLNLENGGFCTSAGALWIYPTNCPVRDYQLHIARTALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYRVMGIPQSHMAEMTGSTQAFTRKEIWSSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFRVLALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILPYSHERRVEKLVVPLGEELEAIQKAYIQILEAFASSLIQRNVLMRKDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRAKNELSRNADFMKLYDHLDSMFSHTRSTSTSGVSAIQKGGKDKKFCYSHPKLKKLEEVVVEHFKSWNARKTSDKKCDETRVMIFSSFRDSVQEIAEMLLPHQPIIRVMTFVGHASGKSMKGFTQKEQLEVVKQFRSGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRKRQGRIVVILAEGREERTYNQSQCNKRSIYKAISGNRQVLHFYQGSPRMVPDGVNPQLHKMFITHGVYEPEKPSRNLPRKSSIFSYRNGIKQSNSKDDWFLSEEEFKLWNRRYRLRDTDEIQQITLPQVQFLSLHNEENRPTEEPTVGIRQLSLSEWRLWQDHPLPTYQVDHSDRCHHFINIMQMIEGMRHEEGECSYESEIKSYLRMEDVSSASSALRNEYNSFADGTFTNNRKSSFANINHRKSVSMTESDEECTEIFKQIPIKSTKIPSLKKKASENLKKDQPKKENKDVVMEPLDTDDSPTTEHILQVDPRNGERVSDTGEVTATCAVSENGGNPSCGLLTDCQFTIKSTGSFTGSFFDSGYNSFSDEKSFSASLFLSFEGELDIAKTDDQFFHCHSLTKEVLANVERFLSHSPPPLSGLSDLENEISEGSALENLVFLPYSECLQNDKSTNLMACSAVNSQQNLKFITHLSEKTCIYGTTNDKISDEPSFCDSDKVHKDSKNEHLVSSNQIQINISPSKDFAEEKNHDVDNSDLPILHTAQDESLLLFEDVNTEFNDVSPPPLNSKCESLGISDRTAVSEMAPVSQFFISDELLLENDSEPQDQIVCDTNSWKSHEGLRGRHEGKLNNDENGFDCSKDLFSVTFDLGFCSTGSEDEVVDHASDTNNEILDDLPGRRLDIKQINSTNCVSNQAVMSGAHVDNSTSVTTTHPSSEDKQTPAFSCFSMNATKSKEFMSPSYSQFLLPVGDKVMSTPLSESNILNSFSEKRMEMAKKSGSNMGKVNLHSFKETLNSTFGDSGLSTGKYKSKKQINLHQACHSTEDEQLSTHESEDDEIFRRKSKKTKGNVLESPENQKNSEVDSPLQVVKKHRVPPNRLDLSSSDESDNFHKRDPQSEDFTDHKRNAKRSIKVQKRQNHLKLVARKFLDEEAELSQEDAEYVSSDENDESEGEQDSSLLDFLNDETQLSQAINDSEMRAVYMKSVRSPLMSNRYKMAHKKHNINIFSQIPEQDETYLEDSFCVDEEESCESQSSEEVCVDFNLITEDCDTNESKKYKTRRAVKLKQMKMRQNCARSKNKLSRIILLDDSSEEEKDVKDKQESRTVVNPSTVPPGSSLQSRDHSHPVDNQLLHQRQQTPPNLKVPDSDVSDFKPQSLTNTESASSLFTAVGAQEDCRKFPVQLKGASALQDSGTCVPCCSNSRPRLADTHASLRLPQEGHRTCILVDSREIVSGSEVVSSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSINKNKLIDQIQYLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLATLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNICETLQFYLSIPNISYITALNMCHQFSSVKKMTNSTPQEISMYAQVTHQKAEEIYRYIHYIFDMQMLPADLNQVLIQSRLSR", "length": 2039, "header": "tr|A0A3Q1MT39-1|A0A3Q1LT80_BOVIN Computationally mapped isoform of RNA helicase OS=Bos taurus OX=9913 GN=FANCM PE=3 SV=1 CANONICAL=A0A3Q1LT80-1" }, "locus": { "chromosome": "21", "start_pos": 54946995, "end_pos": 54856875, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071085.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071085.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073359.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073359.1" } ] } }, { "isoform_ac": "A0AAF6DLJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLJ6/entry", "sequence": { "sequence": "MSGRQRTLFQTWGSKVSRSTGAPTCNSGTERPQSTGISRARFPAVAEAAGAAEVEPESDDDVLLVAVYEAERQLNLENGGFCTSAGALWIYPTNCPVRDYQLHIARTALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYRVMGIPQSHMAEMTGSTQAFTRKEIWSSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFRVLALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILPYSHERRVEKLVVPLGEELEAIQKAYIQGIQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRAKNELSRNADFMKLYDHLDSMFSHTRSTSTSGVSAIQKGGKDKKFCYSHPKLKKLEEVVVEHFKSWNARKTSDKKCDETRVMIFSSFRDSVQEIAEMLLPHQPIIRVMTFVGHASGKSMKGFTQKEQLEVVKQFRSGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRKRQGRIVVILAEGREERTYNQSQCNKRSIYKAISGNRQVLHFYQGSPRMVPDGVNPQLHKMFITHGVYEPEKPSRNLPRKSSIFSYRNGIKQSNSKDDWFLSEEEFKLWNRRYRLRDTDEIQQITLPQVQFLSLHNEENRPTEEPTVGIRQLSLSEWRLWQDHPLPTYQVDHSDRCHHFINIMQMIEGMRHEEGECSYESEIKSYLRMEDVSSASSALRNEYNSFADGTFTNNRKSSFANINHRKSVSMTESDEECTEIFKQIPIKSTKIPSLKKKASENLKKDQPKKENKDVVMEPLDTDDSPTTEHILQVDPRNGERVSDTGEVTATCAVSENGGNPSCGLLTDCQFTIKSTGSFTGSFFDSGYNSFSDEKSFSASLFLSFEGELDIAKTDDQFFHCHSLTKEVLANVERFLSHSPPPLSGLSDLENEISEGSALENLVFLPYSECLQNDKSTNLMACSAVNSQQNLKFITHLSEKTCIYGTTNDKISDEPSFCDSDKVHKDSKNEHLVSSNQIQINISPSKDFAEEKNHDVDNSDLPILHTAQDESLLLFEDVNTEFNDVSPPPLNSKCESLGISDRTAVSEMAPVSQFFISDELLLENDSEPQDQIVCDTNSWKSHEGLRGRHEGKLNNDENGFDCSKDLFSVTFDLGFCSTGSEDEVVDHASDTNNEILDDLPGRRLDIKQINSTNCVSNQAVMSGAHVDNSTSVTTTHPSSEDKQTPAFSCFSMNATKSKEFMSPSYSQFLLPVGDKVMSTPLSESNILNSFSEKRMEMAKKSGSNMGKVNLHSFKETLNSTFGDSGLSTGKYKSKKQINLHQACHSTEDEQLSTHESEDDEIFRRKSKKTKGNVLESPENQKNSEVDSPLQVVKKHRVPPNRLDLSSSDESDNFHKRDPQSEDFTDHKRNAKRSIKVQKRQNHLKLVARKFLDEEAELSQEDAEYVSSDENDESEGEQDSSLLDFLNDETQLSQAINDSEMRAVYMKSVRSPLMSNRYKMAHKKHNINIFSQIPEQDETYLEDSFCVDEEESCESQSSEEVCVDFNLITEDCDTNESKKYKTRRAVKLKQMKMRQNCARSKNKLSRIILLDDSSEEEKDVKDKQESRTVVNPSTVPPGSSLQSRDHSHPVDNQLLHQRQQTPPNLKVPDSDVSDFKPQSLTNTESASSLFTAVGAQEDCRKFPVQLKGASALQDSGTCVPCCSNSRPRLADTHASLRLPQEGHRTCILVDSREIVSGSEVVSSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSINKNKLIDQIQYLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLATLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNICETLQFYLSIPNISYITALNMCHQFSSVKKMTNSTPQEISMYAQVTHQKAEEIYRYIHYIFDMQMLPADLNQGSIKSDT", "length": 1993, "header": "tr|A0AAF6DLJ6-1|A0A3Q1LT80_BOVIN Computationally mapped isoform of RNA helicase OS=Bos taurus OX=9913 GN=FANCM PE=3 SV=1 CANONICAL=A0A3Q1LT80-1" }, "locus": { "chromosome": "21", "start_pos": 54915157, "end_pos": 54856875, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043352.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043352.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040927.5", "url": "https://www.ensembl.org/id/ENSBTAP00000040927.5" } ] } }, { "isoform_ac": "F1MLX2-1", "url": "https://www.uniprot.org/uniprotkb/F1MLX2/entry", "sequence": { "sequence": "MSGRQRTLFQTWGSKVSRSTGAPTCNSGTERPQSTGISRARFPAVAEAAGAAEVEPESDDDVLLVAVYEAERQLNLENGGFCTSAGALWIYPTNCPVRDYQLHIARTALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYRVMGIPQSHMAEMTGSTQAFTRKEIWSSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFRVLALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILPYSHERRVEKLVVPLGEELEAIQKAYIQILEAFASSLIQRNVLMRKDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRAKNELSRNADFMKLYDHLDSMFSHTRSTSTSGVSAIQKARKTSDKKCDETRVMIFSSFRDSVQEIAEMLLPHQPIIRVMTFVGHASGKSMKGFTQKEQLEVVKQFRSGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRKRQGRIVVILAEGREERTYNQSQCNKRSIYKAISGNRQVLHFYQGSPRMVPDGVNPQLHKMFITHGVYEPEKPSRNLPRKSSIFSYRNGIKQSNSKDDWFLSEEEFKLWNRRYRLRDTDEIQQITLPQVQFLSLHNEENRPTEEPTVGIRQLSLSEWRLWQDHPLPTYQVDHSDRCHHFINIMQMIEGMRHEEGECSYESEIKSYLRMEDVSSASSALRNEYNSFADGTFTNNRKSSFANINHRKSVSMTESDEECTEIFKQIPIKSTKIPSLKKKASENLKKDQPKKENKDVVMEPLDTDDSPTTEHILQVDPRNGERVSDTGEVTATCAVSENGGNPSCGLLTDCQFTIKSTGSFTGSFFDSGYNSFSDEKSFSASLFLSFEGELDIAKTDDQFFHCHSLTKEVLANVERFLSHSPPPLSGLSDLENEISEGSALENLVFLPYSECLQNDKSTNLMACSAVNSQQNLKFITHLSEKTCIYGTTNDKISDEPSFCDSDKVHKDSKNEHLVSSNQIQINISPSKDFAEEKNHDVDNSDLPILHTAQDESLLLFEDVNTEFNDVSPPPLNSKCESLGISDRTAVSEMAPVSQFFISDELLLENDSEPQDQIVCDTNSWKSHEGLRGRHEGKLNNDENGFDCSKDLFSVTFDLGFCSTGSEDEVVDHASDTNNEILDDLPGRRLDIKQINSTNCVSNQAVMSGAHVDNSTSVTTTHPSSEDKQTPAFSCFSMNATKSKEFMSPSYSQFLLPVGDKVMSTPLSESNILNSFSEKRMEMAKKSGSNMGKVNLHSFKETLNSTFGDSGLSTGKYKSKKQINLHQACHSTEDEQLSTHESEDDEIFRRKSKKTKGNVLESPENQKNSEVDSPLQVVKKHRVPPNRLDLSSSDESDNFHKRDPQSEDFTDHKRNAKRSIKVQKRQNHLKLVARKFLDEEAELSQEDAEYVSSDENDESEGEQDSSLLDFLNDETQLSQAINDSEMRAVYMKSVRSPLMSNRYKMAHKKHNINIFSQIPEQDETYLEDSFCVDEEESCESQSSEEVCVDFNLITEDCDTNESKKYKTRRAVKLKQMKMRQNCARSKNKLSRIILLDDSSEEEKDVKDKQESRTVVNPSTVPPGSSLQSRDHSHPVDNQLLHQRQQTPPNLKVPDSDVSDFKPQSLTNTESASSLFTAVGAQEDCRKFPVQLKGASALQDSGTCVPCCSNSRPRLADTHASLRLPQEGHRTCILVDSREIVSGSEVVSSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSINKNKLIDQIQYLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLATLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNICETLQFYLSIPNISYITALNMCHQFSSVKKMTNSTPQEISMYAQVTHQKAEEIYRYIHYIFDMQMLPADLNQGSIKSDT", "length": 2008, "header": "tr|F1MLX2-1|F1MLX2_BOVIN Computationally mapped isoform of ATP-dependent RNA helicase FANCM OS=Bos taurus OX=9913 GN=FANCM PE=3 SV=4 CANONICAL=A0A3Q1LT80-1" }, "locus": { "chromosome": "21", "start_pos": 54915157, "end_pos": 54856875, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003379.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003379.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003379.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003379.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 253, "start_aa": "Thr", "end_pos": 253, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr253", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-6783310", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6783310", "resource": "Reactome", "description": "Fanconi Anemia Pathway" }, { "id": "R-BTA-9833482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9833482", "resource": "Reactome", "description": "PKR-mediated signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K7F0-1", "protein_name": "RNA helicase", "gene_name": "Fancm", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGRQRTLFQTWGPSLVRGAGAPGCGQPRSPAVTESLPEEDDEVLLVAAYEAEQQLDPGDGGFCAAAGALWIYPTNCPVRDYQLDISRTALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQMEACFHVMGIPQSHMAEMTGSTQAVNRKEIWSSRRVLFLTPQVMVNDLTRGAVPAAHVKCLVVDEAHKALGNYAYCQVVRELVKYTNHFRILALSATPGSDIKAVQQVITNLLIEKIELRSEDSPDILPYSHERRVEKLVVPLGEELGAIQKTYVQILETFASSLIKRNILMKRDIPNLTKYQIILARDQFRKNPSPNIVGVQQGIIEGELAICISLYHGYELLQQLGMRSLYFFLSGIMDGTKGMTRVKTELSRNEDFTKLYSHLQSVFAHVRDAAAASEASAFQKGNKEKKFVYSHPKLKKLEEVILEHFKSWNAKNTTEKKCQESRVMIFSSFRDSVEEIAEMLSQHQPGVRVMTFVGHASGKNTKGYTQKEQLRVVRQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRRRQGRIVVILAEGREERTYNQSQSNKKNIYKAISGNRQVLRLYQGSPRMVPDKINPELHKMFITHGVYESEKARSVQRKSFSSRSGIKAGNSNKDGLLSEEEFNLWNRLYRLGDSDTVKGVALPRSHFLSLQEDRVAQEPTTGIHQLSLSEWSLWQDHPLPTHQVEHSDRCHHFISIMRMIEGMRHEEDECSYELKIKPFLQMEDVYSKYNAPRNGYKNVASVTRIAPKKSSFRPSVDAGGSLSVTESEEGCADTVEQMDSEWTKITSLREKATTVGKGQTREQTDDDHDDADSSDSDRNSPADVVSRVPPSGERVADVGGIPILGAVTEDDSHTGTLLMECQVTEKSLARYSLDSGYSSFSDDKSLSSHLFLPLEEELYTERAAELFYRCQPMTEEVLANVEKFLSHSPPSLSGLSDVEYAVTQGFELDNESCLPYPEREHSPKPGSPYPEREHSPKPASLALYTAVNSQSNLELNSAKHTNPPSEKDCLPATTHNNIPDQPSFCDSDSETHNIKNQNLVSNSYGQIQVNLENNLVDENSHDDSEPPVLFTDEDESLLLFEDDLKNIEDGTEELNGVGLPPLDRISQPLCVSDKTLISEMPPVSHFLISDELLDDDSEPEDQIICDTKCWEGVEGRDEEIKTEGQPFDCSADLFSVTFDLGFCSSGSDDENPARASDRSSTLGTAEVPGRHSDKEVKDASHASGPLGGTISPIPSEKMPWSPCAQSKECAPFHSALSLPVRERAMSTPLSKAHRSSKTGAHVLKTLDSTKEKAGGQGFKVTLNPRFDNLGFSVEETKSSDQLSVYQSPRCPKVEHLTSESEDDVFLKKTRKPKGNVLKSPEDQKNNEVDSPIHVVKKSRVLRSELSSSDDESENFHRPCPKLEYFKDRNRNTRKGSKAQKKRIHMKALARGFLDEEAEVSGEDADCVSSDEGDDSENEKDSSLLDFVNDRTQLSQAINDSEMRAIYMKSVRSPLMSTKYKMVREKHNSMNIFSQIPEQDENYLEDSFCVAEEESCRSQSSEEEIFVDFNLTKDSFTDEDIRYKTRHAVKLKQMNKKQNCTRSRKKLSRIILPDSDSSEEENTANGREDPSAGGHAADKHTQQGQLWASGPSGSVQPKVLCNPAGNQSSGQRLQVLPNIMDAVPGALNVRAQSHNQTKSTSPPCASVESRKECGNRPVQLKVGDQDTSAAPCSASLLPDAEVLIAPRHPREGNRACILVDSREITTGLEVISSLRTVHGLQVEICPLNGCDYIVSNRMVVERKSQSEMLSNTAKNKFIEQIQRLQSMFQRICVIVEKDREKAGDISKMFRRTKCYDSLLTALVGAGIRILFSSGQEETAGLIKELSLVEQRKNAGIHIPAVLDTGTCEALQFYLSIPGVSYVTALNMCHQFSSVKKMVNSSPEEISTCAQVTHQKAEEIYKYIHYTFDMQMLPNDLTQERQKSETCSTL", "length": 2017 }, "evidence": [ { "id": "A0A3Q1LT80", "url": "https://omabrowser.org/oma/group/A0A3Q1LT80/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BGE5-1", "protein_name": "Fanconi anemia group M protein homolog", "gene_name": "Fancm", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGRQRTLFQTWGPSLVRGSGDSGCGQPRSPAMAEALPEEDDEVLLVAAYEAERQLDPGDGGFCAAAGALWIYPTNCPVRDYQLDISRSALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQMEACFHVMGIPQSHMAEMTGSTQAVNRKEIWSSRRVLFLTPQVMVNDLTRGAVPATHVKCLVVDEAHKALGNYAYCQVVRELVKYTTHFRILALSATPGSDIKAVQQVITNLLIGKIELRSEESPDILPYSHERRVEKLVVPLGEELGAIQKTYIQILETFASSLIHRNVLMKRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFALCISLYHGYELLQQMGMRSLYFFLSGIMDGTKGMTRARNELSRNEDFMKLYTHLQSAFAPASTSDASAFQRGNKEKKFVYSHPKLKKLEEVILEHFKSWNAKATTEKKCHESRVMIFSSFRDSVEEIAEMLLQHRPVIRVMTFVGHASGKNTKGFTQKEQLQVVRQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRKRQGRIVVILAEGREERTYNQSQSNKKNIYKAISGNRQVLRLYQGSPRMVPDKINPELHKMYITHGVYEPEKARSVQRRPFSSRGGIKASKSNKDGLLSEEEFNLWSRLYRLGDSDQVKGVALPQSHFPSLQEDRVIQDPTTRIHQLSLSEWSLWQDRPLPTHQVDHSDRCHHFISIMKMIEGMRHEEGECSYELKIRPFLQMEDVCSKYHAPRNGYNNVASVASSAHQKSSFRPSVDAGGSLTVIESEEEHADTVKQRDSKWTKITSLREKPCRAGRKGQTCEHSEGEGEDGDAGSSDADGQSPAEADSQVDPPSGERMADVGGISILGAVTEEDNHPGTLQMECQVTNKSCARYSLDSGYSSFSDEKSVSSNLFLPLEEELFTDRAAEQFYNCRPMTEDVLANVERFLSRSPPSLSGLSDLVYDVTQGCEFDNASCSPYPEHEHSPRPVSPASHSAGNSQQNLESNSAKRISHPTEKYCLPGTTHNKVSDRPSFCESDSEGHNIKYQNSGSNSCAQIQADLENNFVDKNSHDDSEPPVLFTDEDESLLLFEDDFKNIEDGPEELNGASLPPFNSISQPLRVSGKTLTSEMPPVSHFLISDELLLDDDSEPEDQIVCGAKSWKCQEGVEDGQEELRTDGQTFDCSVDLFSVTFDLGFRCSSGSDDEMLAGASDRTRTLGAADVSGRHSDKEIKDAGGASGPLGRAISPIPTETAQWSPWAQNKEYASFHVASSSPVKQRVRSTPLSKSHASSKTGAHMLKTLDSTKEKAGGQGFKMALNPRLGHLGFSVEETKSSDQVFVHQSPRRTEVEHLTSESEDDVFLRKTKKPKRNVLKSPEDQKNNEVDSPIHAVKKPRVLRSELASSDDESENFGRTCPRLEHFKGRNRNIRKGSAAQKNRSQVKTMARRFLDDEAEVSGEDVDCVSADEEDESENEQDSSLLDFVNDRTQLSQAINDSEMRAIYMKSVRSPLMSTKYRMVREKRPNMNIFSQIPEQDENYLEDSFCVDEEESCKSQSSEEEISVDFNLTKDSFTDEDIRYKTRYAVKIKQMNKKQNYTRPRKKLSRIILPDDDSSEEENIPKDREHSVAGGHAAAEHTQQGQLWASGPSGSSVPPQVLSDPSWNQSSRQRLQVQPSITDAVPRTLNVKAQSHNKIKSASPPCTGVESRKEYGNHPVQLKADSQEHSDTSAAPCSTSLLHVAEGHTAPRHLQEGNRACILVDSREITTGLEVISSLRTVHGLQVEICPLNGCDYIVSSRMVVVRRSQSEMLSNTSKNKFIEQMQRLQSMFQRICVIVEKDREKAGDTSKKFRRTKCYDSLLTALVGAGIRILFSSGQEETADLLKELSLVEQRKNAGIHIPAVLNTSKLEALPFYLSIPGISYITALNMCHQFSSVKKMANSSPEEISTCAQVNHQKAEEIYKYIHYIFDMQMLPNDLNQERQKPDTCLTLGVAMKELS", "length": 2021 }, "evidence": [ { "id": "A0A3Q1LT80", "url": "https://omabrowser.org/oma/group/A0A3Q1LT80/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IYD8-1", "protein_name": "Fanconi anemia group M protein", "gene_name": "FANCM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVAAYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEIWCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFRILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAIQKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMFARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSEVDSPLHAVKKRRFPINRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLKSDI", "length": 2048 }, "evidence": [ { "id": "A0A3Q1LT80", "url": "https://omabrowser.org/oma/group/A0A3Q1LT80/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "resolution of meiotic recombination intermediates", "id": "GO:0000712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000712", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ], "pmid": "" }, { "name": "interstrand cross-link repair", "id": "GO:0036297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036297", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ], "pmid": "" }, { "name": "replication fork processing", "id": "GO:0031297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031297", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ], "pmid": "" }, { "name": "positive regulation of protein monoubiquitination", "id": "GO:1902527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902527", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ], "pmid": "" }, { "name": "homologous recombination", "id": "GO:0035825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035825", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ], "pmid": "" }, { "name": "DNA recombination", "id": "GO:0006310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006310", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ], "pmid": "" }, { "name": "double-strand break repair via synthesis-dependent strand annealing", "id": "GO:0045003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045003", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "3'-5' DNA helicase activity", "id": "GO:0043138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043138", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LT80", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": 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"A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": 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"activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": 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{ "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", 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"MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSPGYNSHLQYGADPAAAAAAAFSSYVGSPYDHTPGMAGSLGYHPYAAPLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGGAEQKAVSGCERLQGPPTPAGKETEGSLSDSDFKEPPSEGRLDALPGPPRAGGLSPAGPAAARLAEDPAPHYPSGAPAPGPHPAAGELPPGPGGPSVIHSPPPPPPQAVLAKPKLWSLAEIATSSDKVKDGGGGNEGSPCPPCPGPVAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGHLHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQSQLDLCKDSPYELKKELGFADQCFFWCVETFQFGGGLPGGSRWWSLYHPGSQAEDNMEWRPLLTLDGYAP", "length": 533, "header": "tr|A0A3Q1LTE8-1|A0A3Q1LTE8_BOVIN Isoform 1 of Iroquois homeobox 5 OS=Bos taurus OX=9913 GN=IRX5 PE=3 SV=2 CANONICAL=A0A3Q1LTE8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTE8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTE8/entry", "sequence": { "sequence": 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"https://www.ensembl.org/id/ENSBTAP00000063735.2" } ] } }, { "isoform_ac": "E1B855-1", "url": "https://www.uniprot.org/uniprotkb/E1B855/entry", "sequence": { "sequence": "MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSPGYNSHLQYGADPAAAAAAAFSSYVGSPYDHTPGMAGSLGYHPYAAPLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGGAEQKAVSGCERLQGPPTPAGKETEGSLSDSDFKEPPSEGRLDALPGPPRAGGLSPAGPAAARLAEDPAPHYPSGAPAPGPHPAAGELPPGPGGPSVIHSPPPPPPQAVLAKPKLWSLAEIATSSDKVKDGGGGNEGSPCPPCPGPVAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGHLHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQSQLDLCKDSPYELKKGMSDI", "length": 483, "header": "tr|E1B855-1|E1B855_BOVIN Computationally mapped isoform of Iroquois homeobox 5 OS=Bos taurus OX=9913 GN=IRX5 PE=3 SV=1 CANONICAL=A0A3Q1LTE8-1" }, "locus": { "chromosome": "18", "start_pos": 23237911, "end_pos": 23235250, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006356.5", "url": "https://www.ensembl.org/id/ENSBTAT00000006356.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006356.3", "url": "https://www.ensembl.org/id/ENSBTAP00000006356.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 237, "start_aa": "Thr", "end_pos": 237, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr237", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 432, "start_aa": "Thr", "end_pos": 432, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr432", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:532896", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532896", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K2M1-1", "protein_name": "Iroquois homeobox 5", "gene_name": "Irx5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSPGYNSHLQYGADPAAAAAAAFSYVGSPYDHTPGMAGSLGYHPYAAPLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDLEGPEAGGTEQKAAAGCERLQGPLSPAGKETEGSLSDSDFKESPSEGRHDDLPRPPRAGEPSPAGPATARLAEDAGPHYPAGAPAPGPHPSAGELPPGSGGSSVIHSPPPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGSEGSPCPPCPGPIGGQTLGGSRASPAPAPARSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGHLHGHPGPGPGPTAGPGSHFNGLNQTVLNRADVLAKDPKMLRSQSQLDLCKDSPYELKKGMSDI", "length": 484 }, "evidence": [ { "id": "A0A3Q1LTE8", "url": "https://omabrowser.org/oma/group/A0A3Q1LTE8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P78411-1", "protein_name": "Iroquois-class homeodomain protein IRX-5", "gene_name": "IRX5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSPGYNSHLQYGADPAAAAAAAFSSYVGSPYDHTPGMAGSLGYHPYAAPLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGGAEQKAASGCERLQGPPTPAGKETEGSLSDSDFKEPPSEGRLDALQGPPRTGGPSPAGPAAARLAEDPAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGNEGSPCPPCPGPIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGHLHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQSQLDLCKDSPYELKKGMSDI", "length": 483 }, "evidence": [ { "id": "A0A3Q1LTE8", "url": "https://omabrowser.org/oma/group/A0A3Q1LTE8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q1LXU5-1", "protein_name": "Iroquois homeobox protein 5a", "gene_name": "irx5a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAYPQGYLYQPSASLALYSCPAYSTSVISGPRTEELGRSSSGSAFAPYAGSTAFTSASPGYNSHLPYSADAAAAATFTSYVSSPYDHTTGMAGSIGYHPYAAPLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDEEEDENIDLEKNDDDEPNKPTDKGDSTDTEADHKLINPGEIPCDRFKDETHSKDLDPPLTDSELKEAEERTDLLAEQAKPTTSSPSVLQRGSDLITQEKPSEPGHAASTGNSNVTSVIHSPPSAPKPKLWSLAEIATSSDRCKGSSEASQAAGLSQSTVIASAASPTRSSPQCPLPNNTVLSRPIYYTSPFYPGYTNYSTFGHLHSSHGTNTSSTAHFNGLSQTVLNRAEALVRESKVRSQTQVDLCKDSPYELKKGMSNI", "length": 446 }, "evidence": [ { "id": "A0A3Q1LTE8", "url": "https://omabrowser.org/oma/group/A0A3Q1LTE8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9JKQ4-1", "protein_name": "Iroquois-class homeodomain protein IRX-5", "gene_name": "Irx5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSPGYNSHLQYGADPAAAAAAAFSYVGSPYDHTPGMAGSLGYHPYAAPLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDLEGPESGGAEQKATAGCERLQGPLSPAGKETEGSLSDSDFKESSSEGRHDELPRPPRAGESSPAGPATARLAEDAGPHYPASVPAPGPHPSAGELPPGSGGSSVIHSPPPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGSEGSPCPPCPGPMGGQTLGGSRASPAPAPARSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGHLHGHPGPGPSPTAGPGSHFNGLNQTVLNRADVLAKDPKMLRSQSQLDLCKDSPYELKKGMSDI", "length": 484 }, "evidence": [ { "id": "A0A3Q1LTE8", "url": "https://omabrowser.org/oma/group/A0A3Q1LTE8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTE8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTE8" } ], "pmid": "" }, { "name": "embryonic cranial skeleton morphogenesis", "id": "GO:0048701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048701", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTE8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTE8" } ], "pmid": "" }, { "name": "gonad development", "id": "GO:0008406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008406", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTE8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTE8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTE8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTE8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTE8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTE8" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTE8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTE8" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTE8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTE8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTE8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTE8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 443, "end_pos": 445, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LTE8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 533, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LTE8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LTE8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LTE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTE8" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 117, "end_pos": 174, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 237, 432 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 183, "end_pos": 185 }, { "start_pos": 443, "end_pos": 445 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LTG6-1", "uniprot_ac": "A0A3Q1LTG6", "uniprot_id": "A0A3Q1LTG6_BOVIN", "mass": { "chemical_mass": 99477.0, "monoisotopic_mass": 99477.0 }, "refseq": { "ac": "NP_001179724", "name": "short transient receptor potential channel 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179724" }, "gene_names": [ { "name": "TRPC7", "type": "recommended", "evidence": [ { "id": "A0A3Q1LTG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTG6" } ] }, { "name": "TRPC7", "type": "synonym", "evidence": [ { "id": "NP_001179724", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179724" } ] } ], "protein_names": [ { "name": "Transient receptor potential cation channel subfamily C member 7", "type": "synonym", "evidence": [ { "id": "A0A3Q1LTG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTG6/entry#names_and_taxonomy" } ] }, { "name": "short transient receptor potential channel 7", "type": "synonym", "evidence": [ { "id": "NP_001179724", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179724" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTG6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTG6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRPC7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTG6", "locus": { "chromosome": "7", "start_pos": 47655137, "end_pos": 47806171, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014638", "url": "https://www.ensembl.org/id/ENSBTAG00000014638" } ] } } ], "crossref": [ { "id": "A0A3Q1LTG6", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LTG6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014638", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014638", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540902", "url": "https://www.ncbi.nlm.nih.gov/gene/540902", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005463", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005463", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013555", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013555", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056336", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056336", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540902", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540902", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CLECMEK", "url": "https://omabrowser.org/oma/group/CLECMEK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LTG6", "url": "https://www.orthodb.org/?gene=A0A3Q1LTG6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M8N3", "url": "https://www.orthodb.org/?gene=A0A3Q1M8N3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10117", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10117:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23317", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23317", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-114508", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114508", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-139853", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-139853", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3295583", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3295583", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179724", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LTG6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTG6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8N3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8N3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8N3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8N3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5H1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5H1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5H1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5H1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTE4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFGSSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILSHPAFAQGQRLALSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSLGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKASEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFRKTRYQAGMRNSENLTANNTYSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI", "length": 862, "header": "tr|A0A3Q1LTG6-1|A0A3Q1LTG6_BOVIN Isoform 1 of Transient receptor potential cation channel subfamily C member 7 OS=Bos taurus OX=9913 GN=TRPC7 PE=4 SV=1 CANONICAL=A0A3Q1LTG6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTG6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTG6/entry", "sequence": { "sequence": "MFGSSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILSHPAFAQGQRLALSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSLGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKASEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFRKTRYQAGMRNSENLTANNTYSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI", "length": 862, "header": "tr|A0A3Q1LTG6-1|A0A3Q1LTG6_BOVIN Isoform 1 of Transient receptor potential cation channel subfamily C member 7 OS=Bos taurus OX=9913 GN=TRPC7 PE=4 SV=1 CANONICAL=A0A3Q1LTG6-1" }, "locus": { "chromosome": "7", "start_pos": 47805948, "end_pos": 47655726, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070979.1", "url": "https://www.ensembl.org/id/ENSBTAT00000070979.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060365.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060365.1" } ] } }, { "isoform_ac": "A0A3Q1M8N3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8N3/entry", "sequence": { "sequence": "MFGSSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILSHPAFAQGQRLALSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKASEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFRKTRYQAGMRNSENLTANNTYSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI", "length": 807, "header": "tr|A0A3Q1M8N3-1|A0A3Q1LTG6_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily C member 7 OS=Bos taurus OX=9913 GN=TRPC7 PE=4 SV=2 CANONICAL=A0A3Q1LTG6-1" }, "locus": { "chromosome": "7", "start_pos": 47805948, "end_pos": 47655726, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069257.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069257.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066817.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066817.2" } ] } }, { "isoform_ac": "A0AAA9S5H1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5H1/entry", "sequence": { "sequence": "MFGSSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILSHPAFAQGQRLALSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSLGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKASEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFRKTRYQAGMRNSENLTANNTYSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI", "length": 801, "header": "tr|A0AAA9S5H1-1|A0A3Q1LTG6_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily C member 7 OS=Bos taurus OX=9913 GN=TRPC7 PE=4 SV=1 CANONICAL=A0A3Q1LTG6-1" }, "locus": { "chromosome": "7", "start_pos": 47805948, "end_pos": 47655726, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104228.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104228.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081184.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081184.1" } ] } }, { "isoform_ac": "A0AAA9TTE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTE4/entry", "sequence": { "sequence": "MFGSSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILSHPAFAQGQRLALSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKASEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFRKTRYQAGMRNSENLTANNTYSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI", "length": 746, "header": "tr|A0AAA9TTE4-1|A0A3Q1LTG6_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily C member 7 OS=Bos taurus OX=9913 GN=TRPC7 PE=4 SV=1 CANONICAL=A0A3Q1LTG6-1" }, "locus": { "chromosome": "7", "start_pos": 47805948, "end_pos": 47655726, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121316.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121316.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100620.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100620.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540902", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540902", "resource": "KEGG Pathway" }, { "id": "R-BTA-114508", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114508", "resource": "Reactome", "description": "Effects of PIP2 hydrolysis" }, { "id": "R-BTA-139853", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-139853", "resource": "Reactome", "description": "Elevation of cytosolic Ca2+ levels" }, { "id": "R-BTA-3295583", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3295583", "resource": "Reactome", "description": "TRP channels" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QQ93-1", "protein_name": "Transient receptor potential cation channel subfamily C member 7", "gene_name": "TRPC7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLGSSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSLGLPFLAVAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMEWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKASEAQLYVDQHVQDDTLQNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFRKTRYQAGMRNSENLTANNTFSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI", "length": 862 }, "evidence": [ { "id": "A0A3Q1LTG6", "url": "https://omabrowser.org/oma/group/A0A3Q1LTG6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z017-1", "protein_name": "Transient receptor potential cation channel subfamily C member 7", "gene_name": "TRPC7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLRNSNYKNMHRRHTTLREKGRRQAIRGPAYMFNEKGTSLTAEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECIEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNIHLCPEHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKNLPNETITDHPKQIFRVKTTQFSWTELLIMKWVLGMIWSECKEIWEEGPREYVVHLWNLLDFGMLSIFVASFTARFMAFLKATEAQQYVDQYVQDDDLNNVTLPPEVAYFTYARNKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFLAFMIGMFNLYSYYLGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLILRIKMCLIKLCKSKAKNCENDLEMGMLNSKQRKVRFQSSSLHTENFSVKNAYNKPTRYQVPTLPPSGFYYLGHLQHTKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELARLIQQLSDKFGKNLNKDI", "length": 871 }, "evidence": [ { "id": "A0A3Q1LTG6", "url": "https://omabrowser.org/oma/group/A0A3Q1LTG6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1LQF7-1", "protein_name": "Transient receptor potential cation channel, subfamily C, member 7", "gene_name": "Trpc7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPVSHTDASPSHSLGNFPQIRKRTGRQVGHRRRVFTHKGKQSAPPHNRNSALWSRSRLQHHGERHLLLGHPWGARSPRLRTGFRSSRGGTSLRILLSMLGSNTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILSHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNLQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSVFVASFTARFMAFLKASEAQLYVDQYVQDVTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKRCENDLEMGMLNSKFRTRYQAGMRNSENLTANSTFSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI", "length": 958 }, "evidence": [ { "id": "A0A3Q1LTG6", "url": "https://omabrowser.org/oma/group/A0A3Q1LTG6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9HCX4-1", "protein_name": "Short transient receptor potential channel 7", "gene_name": "TRPC7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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RNA-binding protein with serine-rich domain 1 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0A3Q1LTK1-1" }, "locus": { "chromosome": "7", "start_pos": 3627257, "end_pos": 3625454, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077491.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077491.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060658.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060658.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTK1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTK1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTK1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTK1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTK1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTK1" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTK1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTK1" } ], "pmid": "" }, { "name": "ASAP complex", "id": "GO:0061574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061574", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTK1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTK1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "id": "GO:0000184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000184", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTK1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTK1" } ], "pmid": "" }, { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTK1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTK1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 172, "end_pos": 174, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LTK1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 299, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LTK1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LTK1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LTK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTK1" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 162, "end_pos": 239, "start_aa": "Thr", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 172, "end_pos": 174 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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} ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TDRD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4", "locus": { "chromosome": "21", "start_pos": 68582287, "end_pos": 68471518, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020402", "url": "https://www.ensembl.org/id/ENSBTAG00000020402" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020402", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020402", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18791", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18791", "database": "CDD", "categories": [ 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035437", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035437", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047384", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047384", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LTL4", "url": "https://www.orthodb.org/?gene=A0A3Q1LTL4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M5G5", "url": "https://www.orthodb.org/?gene=A0A3Q1M5G5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MM37", "url": "https://www.orthodb.org/?gene=A0A3Q1MM37", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N558", "url": 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"categories": [ "Protein Classification", "Other" ] }, { "id": "PF21010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTL4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5G5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5G5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5G5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM37", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM37-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM37-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N558", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N558", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N558-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N558-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3I8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3I8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3I8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNA1", "url": "https://www.uniprot.org/uniprotkb/F1MNA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNA1-1", "url": "https://www.uniprot.org/uniprotkb/F1MNA1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRKLTLDQINDWFTIGKMVTNVELLGSPPAFPAEAARDEAQRRDAAPSSDPEAEGQAESPAEAPAEAPVLAEAQAEAQHQDQEQAPAQAQATLALPWRLLGEKSADTEYIDKYRQLEAQEFYLYFLDHLISGSDKTGPRPPLAKSSHVMRIPETAYKYPELPISRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYLQRSAYCNIVVTQPRKIGASSIARWISRERGWVLGGLVGYQVGLEKIATEDTKLIYMTTGVLLQKIVSAKSLVEFTHVFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATINCREFADYFAVPVQNKMSPAYIFEVEGKPFSIEEYYLNDLEHVHHSRLSPHLLEEPVITRAVYEVAISLIQMFDDLDMKESGAKTPSGSPFLSERSSVLVFLPGLGEINYMHELLTNMVHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCEQRKGRAGRVSKGYCYRLVHKDFWDNSIPNHVIPEMLRCPLGSTILKVKLLDMGEPRALLATALSPPSLSDIERTILLLKEVGALAVSGRREDDNPHDGELTFLGRVLAQLPVSQQLGKLIVLGHVFGCLDECLIIAASLSLKNFFAMPFRQHLDGYRNKVNFAGSSRSDCIALVEAFRAWQTCRQRGELRHPKDELDWGRLNYIQIKRIREVAELYEELKTRVSQFNMYVDSRRPVLDQEYKYKQRFILQVVLAGAFYPNYFTFGQPDEEIATRELAGKDPKTTIVLKHIPPYGFLYHQQLQSLFRQCGQVKSIVFDGAKAFVEFSRNPTERFKTLPAVYMAIKMSQLKVSLELSVHSAEEIEAKVQGGAVSKLRNTSSRGLVRAVASHTVNVDFQKKTVDPVQVSFNMVDQSRTITDLLLTVEVTEVVEVGHFWGYRTDEKNWEFLKSLAAEINRLTLVPLPVHPHPDQVCLAPFADSDKESYFRAQVLYVSGNSAEVFFVDYGNRARVALGVLMEMPCQFLELPFQALEFKICKMRPSARCLVCGERWSSGASQRFSSLVGGRTLLVKVFSMVHSVLHVDAYLPSGLQDTVSVRGILISQGYAEPAEEPYESKQSHEALKGLFSKSVEDLTDMSTASPVKDDEKHLIRILLESFSSNKLGNPSCKAVLHGPFNPYELKCHSLTRISKFRCVWIEKESINSVIISDSPEDTHQRLLVAASLSVNTTGSTMLLRETSLMPHIPGLPALLSMLFAPVMELRVDQDGRCYTGVLCGLGCNPTTGAPVLPEHDMELAFDVQFSVEDIVEINILRAAVNKLVCDGPNGSKCLGPERIAQLQDNSRQKLLGLFCQLKPREKVVPKWYEKPYEWNQVDPKLVMEQADRESSRGKNTFLYQLHRLIVLSS", 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"MLRKLTLDQINDWFTIGKMVTNVELLGSPPAFPAEAARDEAQRRDAAPSSDPEAEGQAESPAEAPAEAPVLAEAQAEAQHQDQEQAPAQAQATLALPWRLLGEKSADTEYIDKYRQLEAQEFYLYFLDHLISGSDKTGPRPPLAKSSHVMRIPETAYKYPELPISRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYLQRSAYCNIVVTQPRKIGASSIARWISRERGWVLGGLVGYQVGLEKIATEDTKLIYMTTGVLLQKIVSAKSLVEFTHVFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATINCREFADYFAVPVQNKMSPAYIFEVEGKPFSIEEYYLNDLEHVHHSRLSPHLLEEPVITRAVYEVAISLIQMFDDLDMKESGAKTPSGSPFLSERSSVLVFLPGLGEINYMHELLTNMVHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCEQRKGRAGRVSKGYCYRLVHKDFWDNSIPNHVIPEMLRCPLGSTILKVKLLDMGEPRALLATALSPPSLSDIERTILLLKEVGALAVSGRREDDNPHDGELTFLGRVLAQLPVSQQLGKLIVLGHVFGCLDECLIIAASLSLKNFFAMPFRQHLDGYRNKVNFAGSSRSDCIALVEAFRAWQTCRQRGELRHPKDELDWGRLNYIQIKRIREVAELYEELKTRVSQFNMYVDSRRPVLDQEYKYKQRFILQVVLAGAFYPNYFTFGQPDEEIATRELAGKDPKTTIVLKHIPPYGFLYHQQLQSLFRQCGQVKSIVFDGAKAFVEFSRNPTERFKTLPAVYMAIKMSQLKVSLELSVHSAEEIEAKVQGGAVSKLRNTSSRGLVRAVASHTVNVDFQKKTVDPVQVSFNMVDQSRTITDLLLTVEVTEVVEVGHFWGYRTDEKNWEFLKSLAAEINRLTLVPLPVHPHPDQVCLAPFADSDKESYFRAQVLYVSGNSAEVFFVDYGNRARVALGVLMEMPCQFLELPFQALEFKICKMRPSARCLVCGERWSSGASQRFSSLVGGRTLLVKVFSMVHSVLHVDAYLPSGLQDTVSVRGILISQGYAEPAEEPYESKQSHEALKGLFSKSVEDLTDMSTASPVKDDEKHLIRILLESFSSNKLGNPSCKAVLHGPFNPYELKCHSLTRISKFRCVWIEKESINSVIISDSPEDTHQRLLVAASLSVNTTGSTMLLRETSLMPHIPGLPALLSMLFAPVMELRVDQDGRCYTGVLCGLGCNPTTGAPVLPEHDMELAFDVQFSVEDIVEINILRAAVNKLVCDGPNGSKCLGPERIAQLQDNSRQKLLGLFCQLKPREKVVPKWYEKPYEWNQVDPKLVMEQADRESSRGKNTFLYQLHRLIVLSS", "length": 1424, "header": "tr|A0A3Q1LTL4-1|A0A3Q1LTL4_BOVIN Isoform 1 of ATP-dependent RNA helicase TDRD9 OS=Bos taurus OX=9913 GN=TDRD9 PE=3 SV=2 CANONICAL=A0A3Q1LTL4-1" }, "locus": { "chromosome": "21", "start_pos": 68581283, "end_pos": 68471717, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082193.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082193.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060416.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060416.2" } ] } }, { "isoform_ac": "A0A3Q1M5G5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5G5/entry", "sequence": { "sequence": "MRVIKECPRPPLAKSSHVMRIPETAYKYPELPISRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYLQRSAYCNIVVTQPRKIGASSIARWISRERGWVLGGLVGYQVGLEKIATEDTKLIYMTTGVLLQKIVSAKSLVEFTHVFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATINCREFADYFAVPVQNKMSPAYIFEVEGKPFSIEEYYLNDLEHVHHSRLSPHLLEEPVITRAVYEVAISLIQMFDDLDMKESGAKTPSGSPFLSERSSVLVFLPGLGEINYMHELLTNMVHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCEQRKGRAGRVSKGYCYRLVHKDFWDNSIPNHVIPEMLRCPLGSTILKVKLLDMGEPRALLATALSPPSLSDIERTILLLKEVGALAVSGRREDDNPHDGELTFLGRVLAQLPVSQQLGKLIVLGHVFGCLDECLIIAASLSLKNFFAMPFRQHLDGYRNKVNFAGSSRSDCIALVEAFRAWQTCRQRGELRHPKDELDWGRLNYIQIKRIREVAELYEELKTRVSQFNMYVDSRRPVLDQEYKYKQRFILQVVLAGAFYPNYFTFGQPDEEIATRELAGKDPKTTIVLKHIPPYGFLYHQQLQSLFRQCGQVKSIVFDGAKAFVEFSRNPTERFKTLPAVYMAIKMSQLKVSLELSVHSAEEIEAKVQGGAVSKLRNTRVNVDFQKKTVDPVQVSFNMVDQSRTITDLLLTVEVTEVVEVGHFWGYRTDEKNWEFLKSLAAEINRLTLVPLPVHPHPDQVCLAPFADSDKESYFRAQVLYVSGNSAEVFFVDYGNRARVALGVLMEMPCQFLELPFQALEFKICKMRPSARCLVCGERWSSGASQRFSSLVGGRTLLVKVFSMVHSVLHVDAYLPSGLQDTVSVRGILISQGYAEPAEEPYESKQSHEALKGLFSKSVEDLTDMSTASPVKDDEKHLIRILLESFSSNKLGNPSCKAVLHGPFNPYELKCHSLTRISKFRCVWIEKESINSVIISDSPEDTHQRLLVAASLSVNTTGSTMLLRETSLMPHIPGLPALLSMLFAPVMELRVDQDGRCYTGVLCGLGCNPTTGAPVLPEHDMELAFDVQFSVEDIVEINILRAAVNKLVCDGPNGSKCLGPERIAQLQDNSRQKLLGLFCQLKPREKVVPKWYEKPYEWNQVDPKLVMEQADRESSRGKNTFLYQLHRLIVLSS", "length": 1281, "header": "tr|A0A3Q1M5G5-1|A0A3Q1LTL4_BOVIN Computationally mapped isoform of ATP-dependent RNA helicase TDRD9 OS=Bos taurus OX=9913 GN=TDRD9 PE=3 SV=2 CANONICAL=A0A3Q1LTL4-1" }, "locus": { "chromosome": "21", "start_pos": 68581283, "end_pos": 68495075, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086307.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086307.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065145.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065145.2" } ] } }, { "isoform_ac": "A0A3Q1MM37-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM37/entry", "sequence": { "sequence": "MLRKLTLDQINDWFTIGKMVTNVELLGSPPAFPAEAARDEAQRRDAAPSSDPEAEGQAESPAEAPAEAPVLAEAQAEAQHQDQEQAPAQAQATLALPWRLLGEKSADTEYIDKYRQLEAQEFYLYFLDHLISGSDKTGPRPPLAKSSHVMRIPETAYKYPELPISRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYLQRSAYCNIVVTQPRKIGASSIARWISRERGWVLGGLVGYQVGLEKIATEDTKLIYMTTGVLLQKIVSAKSLVEFTHVFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATINCREFADYFAVPVQNKMSPAYIFEVEGKPFSIEEYYLNDLEHVHHSRLSPHLLEEPVITRAVYEVAISLIQMFDDLDMKESGAKTPSGSPFLSERSSVLVFLPGLGEINYMHELLTNMVHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCEQRKGRAGRVSKGYCYRLVHKDFWDNSIPNHVIPEMLRCPLGSTILKVKLLDMGEPRALLATALSPPSLSDIERTILLLKEVGALAVSGRREDDNPHDGELTFLGRVLAQLPVSQQLGKLIVLGHVFGCLDECLIIAASLSLKNFFAMPFRQHLDGYRNKVNFAGSSRSDCIALVEAFRAWQTCRQRGELRHPKDELDWGRLNYIQIKRIREVAELYEELKTRVSQFNMYVDSRRPVLDQEYKYKQRFILQVVLAGAFYPNYFTFGQPDEEIATRELAGKDPKTTIVLKHIPPYGFLYHQQLQSLFRQCGQVKSIVFDGAKAFVEFSRNPTERFKTLPAVYMAIKMSQLKVSLELSVHSAEEIEAKVQGGAVSKLRNTRVNVDFQKKTVDPVQVSFNMVDQSRTITDLLLTVEVTEVVEVGHFWGYRTDEKNWEFLKSLAAEINRLTLVPLPVHPHPDQVCLAPFADSDKESYFRAQVLYVSGNSAEVFFVDYGNRARVALGVLMEMPCQFLELPFQALEFKICKMRPSARCLVCGERWSSGASQRFSSLVGGRTLLVKVFSMVHSVLHVDAYLPSGLQDTVSVRGILISQGYAEPAEEPYESKQSHEALKGLFSKSVEDLTDMSTASPVKDDEKHLIRILLESFSSNKLGNPSCKAVLHGPFNPYELKCHSLTRISKFRCVWIEKESINSVIISDSPEDTHQRLLVAASLSVNTTGSTMLLRETSLMPHIPGLPALLSMLFAPVMELSDRKSVYVNALCLECFPQSFTDLDDGKGLH", "length": 1298, "header": "tr|A0A3Q1MM37-1|A0A3Q1LTL4_BOVIN Computationally mapped isoform of ATP-dependent RNA helicase TDRD9 OS=Bos taurus OX=9913 GN=TDRD9 PE=3 SV=2 CANONICAL=A0A3Q1LTL4-1" }, "locus": { "chromosome": "21", "start_pos": 68556154, "end_pos": 68471717, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086996.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086996.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072158.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072158.2" } ] } }, { "isoform_ac": "A0A3Q1N558-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N558/entry", "sequence": { "sequence": "MWNSSARHLPSQPRLLGTRHSAGMRPPALTLRLRARLSLQLRLQLRLRSWPRPRPRPSTKTRSRLQPRPRPRWHYHGGPRPPLAKSSHVMRIPETAYKYPELPISRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYLQRSAYCNIVVTQPRKIGASSIARWISRERGWVLGGLVGYQVGLEKIATEDTKLIYMTTGVLLQKIVSAKSLVEFTHVFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATINCREFADYFAVPVQNKMSPAYIFEVEGKPFSIEEYYLNDLEHVHHSRLSPHLLEEPVITRAVYEVAISLIQMFDDLDMKESGAKTPSGSPFLSERSSVLVFLPGLGEINYMHELLTNMVHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCEQRKGRAGRVSKGYCYRLVHKDFWDNSIPNHVIPEMLRCPLGSTILKVKLLDMGEPRALLATALSPPSLSDIERTILLLKEVGALAVSGRREDDNPHDGELTFLGRVLAQLPVSQQLGKLIVLGHVFGCLDECLIIAASLSLKNFFAMPFRQHLDGYRNKVNFAGSSRSDCIALVEAFRAWQTCRQRGELRHPKDELDWGRLNYIQIKRIREVAELYEELKTRVSQFNMYVDSRRPVLDQEYKYKQRFILQVVLAGAFYPNYFTFGQPDEEIATRELAGKDPKTTIVLKHIPPYGFLYHQQLQSLFRQCGQVKSIVFDGAKAFVEFSRNPTERFKTLPAVYMAIKMSQLKVSLELSVHSAEEIEAKVQGGAVSKLRNTRVNVDFQKKTVDPVQVSFNMVDQSRTITDLLLTVEVTEVVEVGHFWGYRTDEKNWEFLKSLAAEINRLTLVPLPVHPHPDQVCLAPFADSDKESYFRAQVLYVSGNSAEVFFVDYGNRARVALGVLMEMPCQFLELPFQALEFKICKMRPSARCLVCGERWSSGASQRFSSLVGGRTLLVKVFSMVHSVLHVDAYLPSGLQDTVSVRGILISQGYAEPAEEPYESKQSHEALKGLFSKSVEDLTDMSTASPVKDDEKHLIRILLESFSSNKLGNPSCKAVLHGPFNPYELKCHSLTRISKFRCVWIEKESINSVIISDSPEDTHQRLLVAASLSVNTTGSTMLLRETSLMPHIPGLPALLSMLFAPVMELRVDQDGRCYTGVLCGLGCNPTTGAPVLPEHDMELAFDVQFSVEDIVEINILRAAVNKLVCDGPNGSKCLGPERIAQLQDNSRQKLLGLFCQLKPREKVVPKWYEKPYEWNQVDPKLVMEQADRESSRGKNTFLYQLHRLIVLSS", "length": 1352, "header": "tr|A0A3Q1N558-1|A0A3Q1LTL4_BOVIN Computationally mapped isoform of ATP-dependent RNA helicase TDRD9 OS=Bos taurus OX=9913 GN=TDRD9 PE=3 SV=2 CANONICAL=A0A3Q1LTL4-1" }, "locus": { "chromosome": "21", "start_pos": 68581283, "end_pos": 68471781, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082157.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082157.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065190.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065190.2" } ] } }, { "isoform_ac": "A0AAA9S3I8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3I8/entry", "sequence": { "sequence": "MLRKLTLDQINDWFTIGKMVTNVELLGSPPAFPAEAARDEAQRRDAAPSSDPEAEGQAESPAEAPAEAPVLAEAQAEAQHQDQEQAPAQAQATLALPWRLLGEKSADTEYIDKYRQLEAQEFYLYFLDHLISGSDKTGPRPPLAKSSHVMRIPETAYKYPELPISRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYLQRSAYCNIVVTQPRKIGASSIARWISRERGWVLGGLVGYQVGLEKIATEDTKLIYMTTGVLLQKIVSAKSLVEFTHVFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATINCREFADYFAVPVQNKMSPAYIFEVEGKPFSIEEYYLNDLEHVHHSRLSPHLLEEPVITRAVYEVAISLIQMFDDLDMKESGAKTPSGSPFLSERSSVLVFLPGLGEINYMHELLTNMVHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCEQRKGRAGRVSKGYCYRLVHKDFWDNSIPNHVIPEMLRCPLGSTILKVKLLDMGEPRALLATALSPPSLSDIERTILLLKEVGALAVSGRREDDNPHDGELTFLGRVLAQLPVSQQLGKLIVLGHVFGCLDECLIIAASLSLKNFFAMPFRQHLDGYRNKVNFAGSSRSDCIALVEAFRAWQTCRQRGELRHPKDELDWGRLNYIQIKRIREVAELYEELKTRVSQFNMYVDSRRPVLDQEYKYKQRFILQVVLAGAFYPNYFTFGQPDEEIATRELAGKDPKTTIVLKHIPPYGFLYHQQLQSLFRQCGQVKSIVFDGAKAFVEFSRNPTERFKTLPAVYMAIKMSQLKVSLELSVHSAEEIEAKVQGGAVSKLRNTRVNVDFQKKTVDPVQVSFNMVDQSRTITDLLLTVEVTEVVEVGHFWGYRTDEKNWEFLKSLAAEINRLTLVPLPVHPHPDQVCLAPFADSDKESYFRAQVLYVSGNSAEVFFVDYGNRARVALGVLMEMPCQFLELPFQALEFKICKMRPSARCLVCGERWSSGASQRFSSLVGGRTLLVKVFSMVHSVLHVDAYLPSGLQDTVSVRGILISQGYAEPAEEPYESKQSHEALKGLFSKSVEDLTDMSTASPVKDDEKHLIRILLESFSSNKLGNPSCKAVLHGPFNPYELKCHSLTRISKFRCVWIEKESINSVIISDSPEDTHQRLLVAASLSVNTTGSTMLLRETSLMPHIPGLPALLSMLFAPVMELRVHHEKLGWMKHRLESRLPVEISITSDIQMTPPLWQTVKKN", "length": 1309, "header": "tr|A0AAA9S3I8-1|A0A3Q1LTL4_BOVIN Computationally mapped isoform of ATP-dependent RNA helicase TDRD9 OS=Bos taurus OX=9913 GN=TDRD9 PE=3 SV=1 CANONICAL=A0A3Q1LTL4-1" }, "locus": { "chromosome": "21", "start_pos": 68554513, "end_pos": 68471717, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102064.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102064.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079671.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079671.1" } ] } }, { "isoform_ac": "F1MNA1-1", "url": "https://www.uniprot.org/uniprotkb/F1MNA1/entry", "sequence": { "sequence": "MLRKLTLDQINDWFTIGKMVTNVELLGSPPAFPAEAARDEAQRRDAAPSSDPEAEGQAESPAEAPAEAPVLAEAQAEAQHQDQEQAPAQAQATLALPWRLLGEKSADTEYIDKYRQLEAQEFYLYFLDHLISGSDKTGPRPPLAKSSHVMRIPETAYKYPELPISRCKEEVISLIESNSVVIIHGATGSGKSTQLPQYVLDHYLQRSAYCNIVVTQPRKIGASSIARWISRERGWVLGGLVGYQVGLEKIATEDTKLIYMTTGVLLQKIVSAKSLVEFTHVFIDEVHERTEEMDFLLLVVRKLLRTNSRFVKVVLMSATINCREFADYFAVPVQNKMSPAYIFEVEGKPFSIEEYYLNDLEHVHHSRLSPHLLEEPVITRAVYEVAISLIQMFDDLDMKESGAKTPSGSPFLSERSSVLVFLPGLGEINYMHELLTNMVHKRLQVYPLHSSVTLEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQSLRLSWASKTSCEQRKGRAGRVSKGYCYRLVHKDFWDNSIPNHVIPEMLRCPLGSTILKVKLLDMGEPRALLATALSPPSLSDIERTILLLKEVGALAVSGRREDDNPHDGELTFLGRVLAQLPVSQQLGKLIVLGHVFGCLDECLIIAASLSLKNFFAMPFRQHLDGYRNKVNFAGSSRSDCIALVEAFRAWQTCRQRGELRHPKDELDWGRLNYIQIKRIREVAELYEELKTRVSQFNMYVDSRRPVLDQEYKYKQRFILQVVLAGAFYPNYFTFGQPDEEIATRELAGKDPKTTIVLKHIPPYGFLYHQQLQSLFRQCGQVKSIVFDGAKAFVEFSRNPTERFKTLPAVYMAIKMSQLKVSLELSVHSAEEIEAKVQGGAVSKLRNTRVNVDFQKKTVDPVQVSFNMVDQSRTITDLLLTVEVTEVVEVGHFWGYRTDEKNWEFLKSLAAEINRLTLVPLPVHPHPDQVCLAPFADSDKESYFRAQVLYVSGNSAEVFFVDYGNRARVALGVLMEMPCQFLELPFQALEFKICKMRPSARCLVCGERWSSGASQRFSSLVGGRTLLVKVFSMVHSVLHVDAYLPSGLQDTVSVRGILISQGYAEPAEEPYESKQSHEALKGLFSKSVEDLTDMSTASPVKDDEKHLIRILLESFSSNKLGNPSCKAVLHGPFNPYELKCHSLTRISKFRCVWIEKESINSVIISDSPEDTHQRLLVAASLSVNTTGSTMLLRETSLMPHIPGLPALLSMLFAPVMELRVDQDGRCYTGVLCGLGCNPTTGAPVLPEHDMELAFDVQFSVEDIVEINILRAAVNKLVCDGPNGSKCLGPERIAQLQDNSRQKLLGLFCQLKPREKVVPKWYEKPYEWNQVDSLPLSHRKPSG", "length": 1392, "header": "tr|F1MNA1-1|A0A3Q1LTL4_BOVIN Computationally mapped isoform of ATP-dependent RNA helicase TDRD9 OS=Bos taurus OX=9913 GN=TDRD9 PE=3 SV=4 CANONICAL=A0A3Q1LTL4-1" }, "locus": { "chromosome": "21", "start_pos": 68577946, "end_pos": 68471717, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027199.8", "url": "https://www.ensembl.org/id/ENSBTAT00000027199.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027199.7", "url": "https://www.ensembl.org/id/ENSBTAP00000027199.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ], "pmid": "" }, { "name": "helicase activity", "id": "GO:0004386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ], "pmid": "" }, { "name": "piP-body", "id": "GO:0071547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071547", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ], "pmid": "" }, { "name": "fertilization", "id": "GO:0009566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTL4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ], 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"UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = 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{ "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { 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ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": 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RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", 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"field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"uniprot_ac": "A0A3Q1LTM3", "uniprot_id": "A0A3Q1LTM3_BOVIN", "mass": { "chemical_mass": 292290.0, "monoisotopic_mass": 292290.0 }, "refseq": { "ac": "XP_003587838", "name": "ectopic P granules protein 5 homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587838" }, "gene_names": [ { "name": "EPG5", "type": "recommended", "evidence": [ { "id": "A0A3Q1LTM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3" } ] }, { "name": "EPG5", "type": "synonym", "evidence": [ { "id": "XP_003587838", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587838" } ] } ], "protein_names": [ { "name": "Ectopic P granules protein 5 homolog", "type": "recommended", "evidence": [ { "id": "A0A3Q1LTM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3/entry#names_and_taxonomy" } ] }, { "name": "ectopic P granules protein 5 homolog isoform X1", "type": "synonym", "evidence": [ { "id": "XP_003587838", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587838" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTM3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "EPG5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3", "locus": { "chromosome": "24", "start_pos": 45587866, "end_pos": 45716290, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012067", "url": "https://www.ensembl.org/id/ENSBTAG00000012067" } ] } } ], "crossref": [ { "id": "ENSBTAG00000012067", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012067", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "529859", "url": "https://www.ncbi.nlm.nih.gov/gene/529859", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR051436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058750", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058750", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529859", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529859", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR31139", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31139", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31139:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31139:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF26103", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26103", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26106", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26106", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26573", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26573", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27737", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27737", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27745", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27745", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003587838", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587838", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTM3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTM3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGD7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGD7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEAVRPPRRAKAKGSRTKTKEKKKYETLQREESDEISLAQTSRELGILTPACEFKGDSPKELIDSQLQNDASGQNESEMFDVPLTSLTLSNEETLTCNTESLNMGQEIRACAGDDAVELKVDPEGSVRTTVETPKNFTEMEKDTLLQCRTSESIQQSNVSYIQQEVENLQVRETQNRKEDKEALGLSSEVLQNVGLQSSCEAKDIFQPPRVKKLYPQLPTEIAGDVPALVAVKSLLRNERLYPELPSQPEVVPFTKEQLKIFEPGSWLENVESYLEEFDSMAHQDRHEFYELLLNYSRCRKQLLLAEAELLALTSDCQNAKSRLWHFKEEQLSVQGICADQVKVSGHHRYQRVEMNENALAELKKLFDAKSEHLHQTLALHSYTSVLSRLQVESYIYSLLNSSAVLRSLAIYQEGQASKQAESVPSDLCQLKECISVLFTFTRRVHEDAQFHDDVLLWLQKLVSVLQRAGCPGDHLFLLNHILRCPAGVSKWAVPFIQIKVLNNPSGVFHFMQSLALLMSPVKNRAEFLCHMKPSERNPSSSGPASGTWTLVDEGGEEDEDPETSWILLNEDDLVILLSQFPFHELFQHLLGFKAKGDYLPETTRPQEMMKIFAFANSLVELLAVGLETFNRARYRQFVKRIGYMIRMTLGYVSDHWAQYVSHNQGSGLALQPYSMEKLQVEFDELFLRAVLHVLKAKRLGIWLFMSEMPFGTLSVQMLWKLFYLMHRVESGNLDRLSTALLPAECKKHLQDPEHFVNFEKCLSSMNSSEEICLLTTFAQMAQARRTNVDEDFIKIIVLEIYEVSYVTLSTRETFSKVGRELLGAIAAVHPEIISVLLDRVQDTIDQVGMVSLYLFKELPLYLWRPSASEIAVIRDWLLNYNLTSVKNKLACVILEGLNWGFGEQVSLHLDQAVHAEIALMILEAYQKYLAQKPYAGLLSESMKQVSYLASIVRYGETPETSFNQWAWNLILRLKLHKNDYGIQQNCAAVPFSSTVPEMTESPTFHPLLKAVKAGMPIGCYLALAMTAVGHSIEKFCAEGIPLLGILVQSRHLRTVVHVLDKILPLFYPCQYYLLKNEQFLSHLLLFLHLDSGVPQGVTQQVTHKVAQHLTGASHGDNVKLLNSMIQAHISVSTQPNEVGPVAVLEFWVQALISQHLWYREQPILFLMDHLCKTAFQLRQEDCVQKLLYQQHKNALGYHCDRSLLSSLVSWILAGNITPSFVEGLATPTQVWFAWTVLNMESIFEEDSQLRRVVEGELVINSAFTPDQALKKAQAQLKLPIVPSLQRLLIYRWAQQALLTPSDHPLLPLIWQKFFLLYLHRPGPQYGLPIDGCIGRRFFQSPAHISLLKEMKRRLTEVADFHHAASKALRVPAEGSEGPPESRAGALAYLTSPELHTELVRLFNVYILWLEDENFQKGDTYIPSLPKHYDIHRLAKVMQNQQDLWMEYLNMERVHYEFQETVGLWTQAKLESHSAPCSSSVQLDFTDPLLAKERVLSNLRKHEDPRPPLVLHLMRPPVPVISSAMLLSQKDATELVRTDLNLLQQQARTAALRESQQVALDSELLDTMPKQYVNREEQTTLHLECRGSSGKKCQGAAVVTVQFEGMHKNEAISQQLHVLRKEVKQLQAEAAKPPSLNIVEAAVHAENLITALVNAYQSQPTPGVQKVGISLFFTVVDYVSDETQRHPPTRQFFTSCVEILGQVFISGTKSECRKVLETILKNRRLCSLLSPFFTPSAAPAEFIQLYEKVVKFLREDNSDMIFMLLTKFDLKQWLNSTKPPLSDRTRLLESIHLALTAWGLEPDEDILMPFNLFCKHWTYLLLYQFPDQYSDILRLLMQSSAEQLLSPECWKATLRALGCCTPGCQQGAASVESTVLQSSPDVLLSDKQVMETIQWLSNFFYKLRLSTLDFKSFGLFSKWSPYMADMKTFLGYLVKRLLDSEMACLAQDPSASSKTVLRSLHSVIIQLFKPWILVLEDNESSQRHYPWLESDAVVASSIVQVFTDCIDSLHGCFKDKLLPGDEGALRLHLMHYCEACTAPKMPEFILYAFHSAYQKLPWRDLHPDQMLMEAFFKVERGSPKSCFLFLGSVLCEVNWVSVLSDAWSPSPRPETRGMVVCLLFMMILLGKEDQLVDQTDSPLLTLLGQTSSLSWHLVDIVSYQSVLGYFSSHYQPSVILAKESSAELIVKLLKVSAGLSVPTDSQKHLDAVPKCQAFTHQMVQFLSSLEQNGKITLAVLEQEMSKLLDDIIVFNPPDLDSQTRHMALSSLFMEVLMMMNSATVPTAEFLRGSIRTWIGQKVHGLVVLPLLTAACQSLASVRHMAETTEACITAYFKEGSLKQNLGWGPILVSLQVPELTIEEFLQECLSLGSYLTLYVYLLQCLNSEQTLRNEMKVLLLLSKWLEQVYPSSMQEEAKLFLWWHQVLQLSLVQTEQNDSVLTESVIRILLMLQGRQNLLAEERLSSGILGAIGLGRKSPLSNRFRVAARSMAAFLSVQVPAEDQIRLKPSSELYLSMKAQQALNALESLTSSKQYVEYQDQISQAAQFIKHPGHCLQDGKSFLALLVNCLYPEVHYLDNIR", "length": 2578, "header": "tr|A0A3Q1LTM3-1|A0A3Q1LTM3_BOVIN Isoform 1 of Ectopic P granules protein 5 homolog OS=Bos taurus OX=9913 GN=EPG5 PE=3 SV=2 CANONICAL=A0A3Q1LTM3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTM3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3/entry", "sequence": { "sequence": 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"length": 2578, "header": "tr|A0A3Q1LTM3-1|A0A3Q1LTM3_BOVIN Isoform 1 of Ectopic P granules protein 5 homolog OS=Bos taurus OX=9913 GN=EPG5 PE=3 SV=2 CANONICAL=A0A3Q1LTM3-1" }, "locus": { "chromosome": "24", "start_pos": 45716150, "end_pos": 45588870, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082297.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082297.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060691.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060691.2" } ] } }, { "isoform_ac": "A0A3Q1MGD7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGD7/entry", "sequence": { "sequence": 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"length": 2506, "header": "tr|A0A3Q1MGD7-1|A0A3Q1LTM3_BOVIN Computationally mapped isoform of Ectopic P granules protein 5 homolog OS=Bos taurus OX=9913 GN=EPG5 PE=3 SV=2 CANONICAL=A0A3Q1LTM3-1" }, "locus": { "chromosome": "24", "start_pos": 45716150, "end_pos": 45588870, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081437.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081437.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070243.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070243.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1662, "start_aa": "Thr", "end_pos": 1662, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1662", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:529859", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529859", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "autophagosome maturation", "id": "GO:0097352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097352", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTM3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3" } ], "pmid": "" }, { "name": "endosome to lysosome transport", "id": "GO:0008333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008333", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTM3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3" } ], "pmid": "" }, { "name": "cellular response to dsDNA", "id": "GO:1990786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990786", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTM3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3" } ], "pmid": "" }, { "name": "nucleotide transport", "id": "GO:0006862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006862", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTM3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTM3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTM3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTM3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTM3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1217, "end_pos": 1219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1776, "end_pos": 1778, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1979, "end_pos": 1981, "annotation": 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[] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1662 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1217, "end_pos": 1219 }, { "start_pos": 137, "end_pos": 139 }, { "start_pos": 159, "end_pos": 161 }, { "start_pos": 1776, "end_pos": 1778 }, { "start_pos": 1979, "end_pos": 1981 }, { "start_pos": 2434, "end_pos": 2436 }, { "start_pos": 296, "end_pos": 298 }, { "start_pos": 402, "end_pos": 404 }, { "start_pos": 768, "end_pos": 770 }, { "start_pos": 76, "end_pos": 78 }, { "start_pos": 883, "end_pos": 885 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 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"total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LTM9-1", "uniprot_ac": "A0A3Q1LTM9", "uniprot_id": "A0A3Q1LTM9_BOVIN", "mass": { "chemical_mass": 116186.0, "monoisotopic_mass": 116186.0 }, "refseq": { "ac": "NP_001179124", "name": "golgin subfamily A member 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179124" }, "gene_names": [ { "name": "GOLGA2", "type": "recommended", "evidence": [ { "id": "A0A3Q1LTM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM9" } ] }, { "name": "GOLGA2", "type": "synonym", "evidence": [ { "id": "NP_001179124", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179124" } ] } ], "protein_names": [ { "name": "Golgin A2", "type": "synonym", "evidence": [ { "id": "A0A3Q1LTM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM9/entry#names_and_taxonomy" } ] }, { "name": "golgi autoantigen, golgin subfamily a, 2", "type": "synonym", "evidence": [ { "id": "NP_001179124", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179124" } ] }, { "name": "golgin subfamily A member 2", "type": "synonym", "evidence": [ { "id": "NP_001179124", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179124" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GOLGA2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM9", "locus": { "chromosome": "11", "start_pos": 98866668, "end_pos": 98883294, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011317", "url": "https://www.ensembl.org/id/ENSBTAG00000011317" } ] } } ], "crossref": [ { "id": "A0A3Q1LTM9", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LTM9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011317", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011317", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "508805", "url": "https://www.ncbi.nlm.nih.gov/gene/508805", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508805", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508805", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IQVIIAE", "url": "https://omabrowser.org/oma/group/IQVIIAE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LTM9", "url": "https://www.orthodb.org/?gene=A0A3Q1LTM9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVX0", "url": "https://www.orthodb.org/?gene=A0A3Q1LVX0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BLT0", "url": "https://www.orthodb.org/?gene=E1BLT0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10881", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10881", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10881:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10881:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15070", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15070", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-162658", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-162658", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179124", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTM9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVX0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVX0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLT0", "url": "https://www.uniprot.org/uniprotkb/E1BLT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLT0-1", "url": "https://www.uniprot.org/uniprotkb/E1BLT0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWPPLPPPRPGMSEETRQSKLAAAKKKLREYQQKNSPGVPAGAKKKRKIKNGSSPETTTSGDCPSPEDIQDILEVLVSDLNRSNGVAIPPLDKWKAPKDRAAPVTPSADDTVSPGGVPSPSASPPRVTSMASTQNHDADNGSGPIDESTSFSSTEGLRQLSQQLNGLVSESSSYINGEGLASPANIKNLESRYQELSVALDSSNLTNKQLSSKIEELKQENQETLDQLEKEKKEFEQKLAKEQGALREQLQVHIQTIGILVSEKTELQTALAHTQQAARQKAGESEDLANRLQSSRQRVGELERTLSAVSTQQKQADRYNKELTRERDALKLELYKNNKNNEDLKQHNSELEEKLRLLVIEKSAMKLGIEELQKKLEMSELLLQQFSSQPAPDSSQQLQQALEERAQLETHMEQLKDSLRQLQAERDQYATNLKEENAIWQQKMQQVLEQMSKLKEEKERSVCQAQELETSLAELRNQIAAPPPQEPPAGPSEAEQRLQAETERLQKELESLAGQLQAQVKDNESLSHLNQEQEQRLLELEREAECWGEQAEERKQILETMQSDRTTISRALSQNRELKEQLAELQNGFVRLSNENMEVTSALQSEQHIKKELAKKLGQLQEKLGELKETVEVKGQEVQDLQQQRDEYLNHLQYYVAAYQLHMAACQQLASDKEALHKQVLLQTQLMDRLQHEEVQGKVAMEAARQELQETQERLEAANQQNQQLQAQLTLMAVPGEGDGLESEEQDEEAPRPKLSVPEELESREALVEFFHSALASAEDEQARLRRQLKEQKLHCQRLCHLAATAQDGVEKEAPAPRTGGDSVPAEAHQALQVAMDKLQGRFTELMQEKVDLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKARHQEKEEYISRLAQDKEEMKVKLLELQELVLCLVGERNEWYGKFLAAQNPAGEPTTAPHTCQEPSTADSEGGLQEVSLADTVEPQQGTLPGQTTPENPTAQQIMQLLREIQNPQEHPGLGSNPCIPFFYRADDNDEVKIMVI", "length": 1032, "header": "tr|A0A3Q1LTM9-1|A0A3Q1LTM9_BOVIN Isoform 1 of Golgin A2 OS=Bos taurus OX=9913 GN=GOLGA2 PE=4 SV=1 CANONICAL=A0A3Q1LTM9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTM9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM9/entry", "sequence": { "sequence": "MWPPLPPPRPGMSEETRQSKLAAAKKKLREYQQKNSPGVPAGAKKKRKIKNGSSPETTTSGDCPSPEDIQDILEVLVSDLNRSNGVAIPPLDKWKAPKDRAAPVTPSADDTVSPGGVPSPSASPPRVTSMASTQNHDADNGSGPIDESTSFSSTEGLRQLSQQLNGLVSESSSYINGEGLASPANIKNLESRYQELSVALDSSNLTNKQLSSKIEELKQENQETLDQLEKEKKEFEQKLAKEQGALREQLQVHIQTIGILVSEKTELQTALAHTQQAARQKAGESEDLANRLQSSRQRVGELERTLSAVSTQQKQADRYNKELTRERDALKLELYKNNKNNEDLKQHNSELEEKLRLLVIEKSAMKLGIEELQKKLEMSELLLQQFSSQPAPDSSQQLQQALEERAQLETHMEQLKDSLRQLQAERDQYATNLKEENAIWQQKMQQVLEQMSKLKEEKERSVCQAQELETSLAELRNQIAAPPPQEPPAGPSEAEQRLQAETERLQKELESLAGQLQAQVKDNESLSHLNQEQEQRLLELEREAECWGEQAEERKQILETMQSDRTTISRALSQNRELKEQLAELQNGFVRLSNENMEVTSALQSEQHIKKELAKKLGQLQEKLGELKETVEVKGQEVQDLQQQRDEYLNHLQYYVAAYQLHMAACQQLASDKEALHKQVLLQTQLMDRLQHEEVQGKVAMEAARQELQETQERLEAANQQNQQLQAQLTLMAVPGEGDGLESEEQDEEAPRPKLSVPEELESREALVEFFHSALASAEDEQARLRRQLKEQKLHCQRLCHLAATAQDGVEKEAPAPRTGGDSVPAEAHQALQVAMDKLQGRFTELMQEKVDLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKARHQEKEEYISRLAQDKEEMKVKLLELQELVLCLVGERNEWYGKFLAAQNPAGEPTTAPHTCQEPSTADSEGGLQEVSLADTVEPQQGTLPGQTTPENPTAQQIMQLLREIQNPQEHPGLGSNPCIPFFYRADDNDEVKIMVI", "length": 1032, "header": "tr|A0A3Q1LTM9-1|A0A3Q1LTM9_BOVIN Isoform 1 of Golgin A2 OS=Bos taurus OX=9913 GN=GOLGA2 PE=4 SV=1 CANONICAL=A0A3Q1LTM9-1" }, "locus": { "chromosome": "11", "start_pos": 98883231, "end_pos": 98867421, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084718.1", "url": "https://www.ensembl.org/id/ENSBTAT00000084718.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063838.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063838.1" } ] } }, { "isoform_ac": "A0A3Q1LVX0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVX0/entry", "sequence": { "sequence": "MWPPLPPPRPGMSEETRQSKLAAAKKKLREYQQKNSPGVPAGAKKKRKIKNGSSPETTTSGDCPSPEDIQDILEVLVSDLNRSNGVAIPPLDKWKAPKDRAAPVTPSADDTVSPGGVPSPSASPPRVTSMASTQNHDADNGSGPIDESTSFSSTEGLRQLSQQLNGLVSESSSYINGEGLASPANIKNLESRYQELSVALDSSNLTNKQLSSKIEELEKKEFEQKLAKEQGALREQLQVHIQTIGILVSEKTELQTALAHTQQAARQKAGESEDLANRLQSSRQRVGELERTLSAVSTQQKQADRYNKELTRERDALKLELYKNNKNNEDLKQHNSELEEKLRLLVIEKSAMKLGIEELQKKLEMSELLLQQFSSQPAPDSSQQLQQALEERAQLETHMEQLKDSLRQLQAERDQYATNLKEENAIWQQKMQQVLEQMSKLKEEKERSVCQAQELETSLAELRNQIAAPPPQEPPAGPSEAEQRLQAETERLQKELESLAGQLQAQVKDNESLSHLNQEQEQRLLELEREAECWGEQAEERKQILETMQSDRTTISRALSQNRELKEQLAELQNGFVRLSNENMEVTSALQSEQHIKKELAKKLGQLQEKLGELKETVEVKGQEVQDLQQQRDEYLNHLQYYVAAYQLHMAACQQLASDKEALHKQVLLQTQLMDRLQHEEVQGKVAMEAARQELQETQERLEAANQQNQQLQAQLTLMAVPGEGDGLESEEQDEEAPRPKLSVPEELESREALVEFFHSALASAEDEQARLRRQLKEQKLHCQRLCHLAATAQDGVEKEAPAPRTGGDSVPAEAHQALQVAMDKLQGRFTELMQEKVDLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKARHQEKEEYISRLAQDKEEMKVKLLELQELVLCLVGERNEWYGKFLAAQNPAGEPTTAPHTCQEPSTADSEGGLQEVSLADTVEPQQGTLPGQTTPENPTAQQIMQLLREIQNPQEHPGLGSNPCIPFFYRADDNDEVKIMVI", "length": 1019, "header": "tr|A0A3Q1LVX0-1|A0A3Q1LTM9_BOVIN Computationally mapped isoform of Golgin A2 OS=Bos taurus OX=9913 GN=GOLGA2 PE=4 SV=1 CANONICAL=A0A3Q1LTM9-1" }, "locus": { "chromosome": "11", "start_pos": 98883231, "end_pos": 98867421, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084496.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084496.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061331.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061331.1" } ] } }, { "isoform_ac": "A0AAA9STC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC8/entry", "sequence": { "sequence": "MWPPLPPPRPGMSEETRQSKLAAAKKKLREYQQKNSPGVPAGAKKKRKIKNGSSPETTTSGDCPSPEDIQDILEVLVSDLNRSNGVAIPPLDKWKAPKDRAAPVTPSADDTVSPGGVPSPSASPPRVTSMASTQNHDADNGSGPIDESTSFSSTEGLRQLSQQLNGLVSESSSYINGEGLASPANIKNLEKQENQETLDQLEKEKKEFEQKLAKEQGALREQLQVHIQTIGILVSEKTELQTALAHTQQAARQKAGESEDLANRLQSSRQRVGELERTLSAVSTQQKQADRYNKELTRERDALKLELYKNNKNNEDLKQHNSELEEKLRLLVIEKSAMKLGIEELQKKLEMSELLLQQFSSQPAPDSSQQLQQALEERAQLETHMEQLKDSLRQLQAERDQYATNLKEENAIWQQKMQQVLEQMSKLKEEKERSVCQAQELETSLAELRNQIAAPPPQEPPAGPSEAEQRLQAETERLQKELESLAGQLQAQVKDNESLSHLNQEQEQRLLELEREAECWGEQAEERKQILETMQSDRTTISRALSQNRELKEQLAELQNGFVRLSNENMEVTSALQSEQHIKKELAKKLGQLQEKLGELKETVEVKGQEVQDLQQQRDEYLNHLQYYVAAYQLHMAACQQLASDKEALHKQVLLQTQLMDRLQHEEVQGKVAMEAARQELQETQERLEAANQQNQQLQAQLTLMAVPGEGDGLESEEQDEEAPRPKLSVPEELESREALVEFFHSALASAEDEQARLRRQLKEQKLHCQRLCHLAATAQDGVEKEAPAPRTGGDSVPAEAHQALQVAMDKLQGRFTELMQEKVDLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKARHQEKEEYISRLAQDKEEMKVKLLELQELVLCLVGERNEWYGKFLAAQNPAGEPTTAPHTCQEPSTADSEGGLQEVSLADTVEPQQGTLPGQTTPENPTAQQIMQLLREIQNPQEHPGLGSNPCIPFFYRADDNDEVKIMVI", "length": 1005, "header": "tr|A0AAA9STC8-1|A0A3Q1LTM9_BOVIN Computationally mapped isoform of Golgin A2 OS=Bos taurus OX=9913 GN=GOLGA2 PE=4 SV=1 CANONICAL=A0A3Q1LTM9-1" }, "locus": { "chromosome": "11", "start_pos": 98883231, "end_pos": 98867421, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127364.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127364.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089679.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089679.1" } ] } }, { "isoform_ac": "A0AAA9TFZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFZ7/entry", "sequence": { "sequence": "MWPPLPPPRPGMSEETRQSKLAAAKKKLREYQQKNSPGVPAGAKKKRKIKNGSSPETTTSGDCPSPEDNHDADNGSGPIDESTSFSSTEGLRQLSQQLNGLVSESSSYINGEGLASPANIKNLESRYQELSVALDSSNLTNKQLSSKIEELKQENQETLDQLEKEKKEFEQKLAKEQGALREQLQVHIQTIGILVSEKTELQTALAHTQQAARQKAGESEDLANRLQSSRQRVGELERTLSAVSTQQKQADRYNKELTRERDALKLELYKNNKNNEDLKQHNSELEEKLRLLVIEKSAMKLGIEELQKKLEMSELLLQQFSSQPAPDSSQQLQQALEERAQLETHMEQLKDSLRQLQAERDQYATNLKEENAIWQQKMQQVLEQMSKLKEEKERSVCQAQELETSLAELRNQIAAPPPQEPPAGPSEAEQRLQAETERLQKELESLAGQLQAQVKDNESLSHLNQEQEQRLLELEREAECWGEQAEERKQILETMQSDRTTISRALSQNRELKEQLAELQNGFVRLSNENMEVTSALQSEQHIKKELAKKLGQLQEKLGELKETVEVKGQEVQDLQQQRDEYLNHLQYYVAAYQLHMAACQQLASDKEALHKQVLLQTQLMDRLQHEEVQGKVAMEAARQELQETQERLEAANQQNQQLQAQLTLMAVPGEGDGLESEEQDEEAPRPKLSVPEELESREALVEFFHSALASAEDEQARLRRQLKEQKLHCQRLCHLAATAQDGVEKEAPAPRTGGDSVPAEAHQALQVAMDKLQGRFTELMQEKVDLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKARHQEKEEYISRLAQDKEEMKVKLLELQELVLCLVGERNEWYGKFLAAQNPAGEPTTAPHTCQEPSTADSEGGLQEVSLADTVEPQQGTLPGQTTPENPTAQQIMQLLREIQNPQEHPGLGSNPCIPFFYRADDNDEVKIMVI", "length": 966, "header": "tr|A0AAA9TFZ7-1|A0A3Q1LTM9_BOVIN Computationally mapped isoform of Golgin A2 OS=Bos taurus OX=9913 GN=GOLGA2 PE=4 SV=1 CANONICAL=A0A3Q1LTM9-1" }, "locus": { "chromosome": "11", "start_pos": 98883231, "end_pos": 98867421, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134334.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134334.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095104.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095104.1" } ] } }, { "isoform_ac": "E1BLT0-1", "url": "https://www.uniprot.org/uniprotkb/E1BLT0/entry", "sequence": { "sequence": "MWPPLPPPRPGMSEETRQSKLAAAKKKLREYQQKNSPGVPAGAKKKRKIKNGSSPETTTSGDCPSPEDAPKDRAAPVTPSADDTVSPGGVPSPSASPPRVTSMASTQNHDADNGSGPIDESTSFSSTEGLRQLSQQLNGLVSESSSYINGEGLASPANIKNLESRYQELSVALDSSNLTNKQLSSKIEELKQENQETLDQLEKEKKEFEQKLAKEQGALREQLQVHIQTIGILVSEKTELQTALAHTQQAARQKAGESEDLANRLQSSRQRVGELERTLSAVSTQQKQADRYNKELTRERDALKLELYKNNKNNEDLKQHNSELEEKLRLLVIEKSAMKLGIEELQKKLEMSELLLQQFSSQPAPDSSQQLQQALEERAQLETHMEQLKDSLRQLQAERDQYATNLKEENAIWQQKMQQVLEQMSKLKEEKERSVCQAQELETSLAELRNQIAAPPPQEPPAGPSEAEQRLQAETERLQKELESLAGQLQAQVKDNESLSHLNQEQEQRLLELEREAECWGEQAEERKQILETMQSDRTTISRALSQNRELKEQLAELQNGFVRLSNENMEVTSALQSEQHIKKELAKKLGQLQEKLGELKETVEVKGQEVQDLQQQRDEYLNHLQYYVAAYQLHMAACQQLASDKEALHKQVLLQTQLMDRLQHEEVQGKVAMEAARQELQETQERLEAANQQNQQLQAQLTLMAVPGEGDGLESEEQDEEAPRPKLSVPEELESREALVEFFHSALASAEDEQARLRRQLKEQKLHCQRLCHLAATAQDGVEKEAPAPRTGGDSVPAEAHQALQVAMDKLQGRFTELMQEKVDLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKARHQEKEEYISRLAQDKEEMKVKLLELQELVLCLVGERNEWYGKFLAAQNPAGEPTTAPHTCQEPSTADSEGGLQEVSLADTVEPQQGTLPGQTTPENPTAQQIMQLLREIQNPQEHPGLGSNPCIPFFYRADDNDEVKIMVI", "length": 1005, "header": "tr|E1BLT0-1|A0A3Q1LTM9_BOVIN Computationally mapped isoform of Golgin A2 OS=Bos taurus OX=9913 GN=GOLGA2 PE=4 SV=2 CANONICAL=A0A3Q1LTM9-1" }, "locus": { "chromosome": "11", "start_pos": 98883231, "end_pos": 98867421, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015044.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015044.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015044.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015044.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 105, "start_aa": "Thr", "end_pos": 105, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr105", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:508805", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508805", "resource": "KEGG Pathway" }, { "id": "R-BTA-162658", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-162658", "resource": "Reactome", "description": "Golgi Cisternae Pericentriolar Stack Reorganization" }, { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" }, { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A1IH00-1", "protein_name": "Golgin subfamily A member 2", "gene_name": "golga2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADQNRQIKLAAAKKKLKEFQQKTIPSTGSAGPKKKRKVKGDQTDAPADRRSPENERVDVSQELEEAGAEHVSNPASAINTDNSAPQNYPADANGDEHPLENNRPLSSTESLRQLSQQLNGLLSESSTHINGDSDPPAVNEKELETRNQELSAALDSSALTNTQLTSKLETLTKQSQELSDQLQKERKEFEQKFTKEQGAMREQLQVHIQTIGILVSEKSELQTALSYTQQAARQKAAEAEDLSSRLQASKQRVSELERTLSSVSTQQKQHERHNKELEKERDSLRLEIIRFNNVSEESRQQSSELSEQLKLRVNENSALKLELEDLRKRLEMADVMLQQFSSQSGPPSEHQQLQLLLEEKHQLENHATQLMESVAQLQAERDQYAVQMQEDGRVWKDKTEQLLSQVRLMSEERDSTAAQILELQERIMELENTAAVMSTEQEPQASSQLSGPSETELALQETLRSLQEERDALSLQFQAQVRDNEQLSRLVQEQEVKLQELERQAERASEDAQDRLRILEDVQSDKATISRALTQNRELKDQLAELQNGFVKLTNENMELTSALQSEQHVKKEIARKMGQLQEDLHNAKEQLLESSSELTSVQEQRDQYLAHLQQYSAGYQQLLAEREHLQKQFLQQTQLMDRLQHDEVQGKVQLEQSHMQLQEVQEKLSRLVRDNEELKTEVQELLNGSIMNTSHRDEGDGLESQTLPESFQKSQIAIPEDFESREEMKEFIHSVLSRVEAERDEMSRRLEEERRIHQDTRQQLTALSHDHHHHHHHEPHSTCAETDGSEGVPVEVHEALRVAMEKLQERFTKLMQEKADLKERLEELEHRCIQLSGETDTIGEYIALYQNQRAIMKQKHVEKEQYINMLAKDKEEMKTKLAELQDLVMRLVGERNEWYSRYMSAVGNRDLLNSNAEQIHPAERRMEISGVDAPAVLDMSTAMDVSSSPQSSTAEIQSQSSERPAADPISSPSLRPQEDGTARQIMQLLQEIQNPQSRPAPFLGENPCIPFFYRPDEHDEVKILVV", "length": 1028 }, "evidence": [ { "id": "A0A3Q1LTM9", "url": "https://omabrowser.org/oma/group/A0A3Q1LTM9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "I3LIX0-1", "protein_name": "Golgin subfamily A conserved domain-containing protein", "gene_name": "GOLGA2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWPPLPPPRPGMSEETRQSKLAAAKKKLREYQQKHSPGVPAGAKKKRKIKNGSSPETTTSGDCPTPEDIQDILKVLVSDLNRSNGVAIPPLDKWKAPKDSADLVTSSADDTVSPGGVLSPCASPLRGTSMATTQNHDAENGPVPIDENTSFSSTESLRQLSQQLNGLVSESSPYINGEGLASPANIKKLESRYHELSLALDSSNLTNKQLSSKIEELKQENQETLDQLEKEKKEFEQKLAKEQGALREQLQVHIQTIGILVSEKTELQTALAHTQQAARQKAGESENLASRLQSSRQRVGELERTLSAVSTQQKQADRYNKELTKERDTLKLELYKNNKSNEDLKQQKSELEEKLRLMATEKAAMQLGMEELQKKLEMSELLLQQFSTQPTPDSSQQLQQALEERAQLETCVGQLQDSLRQLQAERDQYVANLKEDSTVWQHKMQQMNEQLNKLRAEKEHSMSQVQELETSLAELRNQAAPPSGPSETEQRLQAEAEQLQKEVESLARQLQAQVKDNENLSLLNQEQEQRLMELERAAECWGEQAEERKQMLESMQSDRTTISRALTQNRKLKEQLAELQNGFVRLSNENMEITSALHSEQHVKKELAKKLGQLQENLGELKETVEVKSQEAQDLQQQRDQYLGHLQQYVAAYQQLAAEKELLHKQMVLQTQLVDQLQHEDMQGRMAVETARQELQEAQGRLEAANQHNQQLQAQLTLMAVPGEGTELDIEDEDKAGEAPRPKLSVPEELDSREAVVEFFNSALASAEEEQARLRRELKEQKLRCQRLAHLVAPAQDGVEKEAPAPGTEGDSVSAPGTGGDSVPVETHQALQVAMDKLQGRFTELMQEKVDLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKERHREKEEYISRLAQDKEEMKVKLLELQELVLHLVGERNEWQGKFLAAQNPAGEPTVAPPAPQELGAAENQGGLLEVSLSDNVEPTQGEALLGQTLTENPTAQQIMQLLREIQNPQERLGLGSNPCIPFFYRADDNDEVKIMVV", "length": 1032 }, "evidence": [ { "id": "A0A3Q1LTM9", "url": "https://omabrowser.org/oma/group/A0A3Q1LTM9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q08379-1", "protein_name": "Golgin subfamily A member 2", "gene_name": "GOLGA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWPQPRLPPRPAMSEETRQSKLAAAKKKLREYQQRNSPGVPTGAKKKKKIKNGSNPETTTSGGCHSPEDTPKDNAATLQPSDDTVLPGGVPSPGASLTSMAASQNHDADNVPNLMDETKTFSSTESLRQLSQQLNGLVCESATCVNGEGPASSANLKDLESRYQQLAVALDSSYVTNKQLNITIEKLKQQNQEITDQLEEEKKECHQKQGALREQLQVHIQTIGILVSEKAELQTALAHTQHAARQKEGESEDLASRLQYSRRRVGELERALSAVSTQQKKADRYNKELTKERDALRLELYKNTQSNEDLKQEKSELEEKLRVLVTEKAGMQLNLEELQKKLEMTELLLQQFSSRCEAPDANQQLQQAMEERAQLEAHLGQVMESVRQLQMERDKYAENLKGESAMWRQRMQQMSEQVHTLREEKECSMSRVQELETSLAELRNQMAEPPPPEPPAGPSEVEQQLQAEAEHLRKELEGLAGQLQAQVQDNEGLSRLNREQEERLLELERAAELWGEQAEARRQILETMQNDRTTISRALSQNRELKEQLAELQSGFVKLTNENMEITSALQSEQHVKRELGKKLGELQEKLSELKETVELKSQEAQSLQQQRDQYLGHLQQYVAAYQQLTSEKEVLHNQLLLQTQLVDQLQQQEAQGKAVAEMARQELQETQERLEAATQQNQQLRAQLSLMAHPGEGDGLDREEEEDEEEEEEEAVAVPQPMPSIPEDLESREAMVAFFNSAVASAEEEQARLRGQLKEQRVRCRRLAHLLASAQKEPEAAAPAPGTGGDSVCGETHRALQGAMEKLQSRFMELMQEKADLKERVEELEHRCIQLSGETDTIGEYIALYQSQRAVLKERHREKEEYISRLAQDKEEMKVKLLELQELVLRLVGDRNEWHGRFLAAAQNPADEPTSGAPAPQELGAANQQGDLCEVSLAGSVEPAQGEAREGSPRDNPTAQQIMQLLREMQNPRERPGLGSNPCIPFFYRADENDEVKITVI", "length": 1002 }, "evidence": [ { "id": "A0A3Q1LTM9", "url": "https://omabrowser.org/oma/group/A0A3Q1LTM9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q62839-1", "protein_name": "Golgin subfamily A member 2", "gene_name": "Golga2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWPPRFPPPRPGMSEETRQSKLAAAKKKLREYQQKNSPGVPAGAKKKKKIKNGHSPERTSASDCQSAENVPTDHTAPAPPSTAAATMFLGVVPSPDADLIQSHDAGNCSNLMEETKTFSSTESLRQLSQQLNGLVSESTSYINGEGLTSSNMKELESRYQELAVALDSSYVTNKQLSSTIEELKQQNQDTLDQLEKEKKDYQQKLAKEQGALREQLQVHIQTIGILVSEKAELQTALAHTQQAARQKAGESEDLASRLQSSRQRVGELERTLSTVSTQQKQADRYNKDLTKERDALKLELYKNGKSNEDLRQQNSELEEKLRVLVAEKAAAQLGAEELQKKLEMSELLLQQFSSQSEASGSNEQLQQAMEERAQLESHVGQLMESLKQLQVERDQYAENLKGESAMWQQRVQQMAEQVHALKEEKEQRESQVQELEASLAELRSQMEEPPPPEPPTGPSEAEERLQGEVEQLQKELEGLTGQLRAQVQDNESLSHLNREQEGRLLELEREAQHWSEQAEERKQILESMQSDRTTISRALSQNRELKEQLAELQNGFVRLTNENMEITSALQSEQHVKKELARKLGELQERLGELKETVELKSQEAQGLQEQRDQCLSHLQQYAAAYQQHLTAYEQLTSEKEALHKQLLLQTQLMDQLQHEEVQGKMAAEMARQELQEAQERLKASSQENQQLQAQLSLLVLPGEDMDQEEQDEEVPQPSLTIPEDLVSREAMVAFCNAAIARAEEEQARLRVQLREQKARCRSLAHLAAPVQSKLEKEAVVPRDMGDSVSEESNQALHVAMEKLQNRFLEVMQEKVELKERVEELEHCCIQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYISRLAQDKEEMKVKLLELQELVLRLVNERNEWQGKFLAVSQNPADVPAPVPTGSQEFGAADQQGDLREVSLADDTEPAQGEAGVPAPQENPTAQQIMQLLREIQNPQERPGLGSNPCIPFFYRADENDEVKIMVI", "length": 998 }, "evidence": [ { "id": "A0A3Q1LTM9", "url": "https://omabrowser.org/oma/group/A0A3Q1LTM9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q921M4-1", "protein_name": "Golgin subfamily A member 2", "gene_name": "Golga2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWPPRFPPPRPGMSEETRQSKLAAAKKKLREYQQKNSPGVPAGAKKKKKIKNGHSPERPTASDCQSPENVPTDHIAPAPPTAATDTMFLGVTPSPDADLTQSHDAGNCSNLMEETKTFSSTESLRQLSQQLNGLVSESTSYINGEGLTSSNMKELENRYQELAVALDSSYVTNKQLSSTIEELKQQNQDTLDQLEKEKKDYQQKLAKEQGSLREQLQVHIQTIGILVSEKAELQTALAHTQQAARQKAGESEDLASRLQSSRQRVGELERTLSTVSTQQKQADRYNKDLTKERDALKLELYKNSKSNEDLRQQNSELEEKLRVLVAEKAAAQLGVEELQKKLEMSELLLQQFSSQSSAAGGNEQLQHAMEERAQLETHVSQLMESLKQLQVERDQYAENLKGESAMWQQRVQQMAEQVHTLKEEKEHRERQVQELETSLAALRSQMEEPPPPEPPAGPSEAEEQLQGEVEQLHKELERLTGQLRAQVQDNESLSHLNREQEGRLLELEREAQRWSEQAEERKQILESMQSDRTTISRALSQNRELKEQLAELQNGFVRLTNENMEITSALQSEQHVKKELARKLGELQERLGELKETVELKSQEAQGLQEQRDQCLSHLQQYAAAYQQHLAAYEQLTSEKEAIHKQLLLQTQLMDQLQHEEVQGKMAAELARQELQEAQERLKATSQENQQLQAQLSLLVLPGEGDVDQEEEDEEVPQSSLAIPEDLDSREAMVAFFNAAIARAEEEQARLRVQLKEQKARCRSLSHLAAPVQSKLEKEAVVPRNVDDSASEESNQALHVAMEKLQSRFLEVMQEKVELKERVEELEHCCIQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYISRLAQDKEEMKVKLLELQELVLRLVNERNEWQGKFLAVSQNPGDVLTPVPTGSQEFGAADQQDDLREVSLADDIEPAQGEAGVPAPHENPTAQQIMQLLREIQNPRERPGLGSNPCIPFFYRADENDEVKIMVV", "length": 999 }, "evidence": [ { "id": "A0A3Q1LTM9", "url": "https://omabrowser.org/oma/group/A0A3Q1LTM9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W289-1", "protein_name": "Golgi matrix protein 130 kD", "gene_name": "GM130", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPDDTQDAKAQKLAAARKKLKEYQQRASNNNGQPGAEEPVAATTQSHSSTVSISSNLSERSDSEINVNGGGAGGTQPPEQSALPTAASYFAQNESEHNGGLADASSLQAIQVIIAEKAQLNAELTKVRLACRERELELEELRILKDQNQLRLEQLQQHCQDQQSTGEQQRQQYAQLQAQLLQSQAQIKDQQSHLNELEAQLKQSNQHQEELQQQLSQKSNELEMAQLKLRQLSDESSVTTDNRVESLVQTQYMYEQQIRDLQAMVGQLTQDKEQAAGQYQNYVQHQSGEIAKLNERNTELSEVLNSLRERERQLVEHVGALERDIQKNISLQAQFKEASQVQPSKEETSEQKALKDELAVLKEQIENFEFERHEFQLKIKSQDDQLQLKNSALDELEKQLERLQAEQPDQSKLLATMESDKVAASRALTQNVEMKNQLDELQQRFVQLTNDKAELVIRLDSEEFANREIRQNYNSMEQKLQANEERFKFKDEEMIRLSHENVELQRQQLMLQQQLDRLRHYEAKAYHAGEETEKENGADAPENEAEEAKEVGLLHNHSHDHSHQHSDGHCHDNDHDHSHEHNHHNAGDHGHPHDHPHDHTHDHSHSHPHDHQHDHPHDHGQNHAHRQAAETLPTAEAVERLQSRFTTLISQVADLTEEKHSLEHLVLQLQSETETIGEYIALYQTQRRMLKQREYEKAAQMRLLQAEREQLREKIEALNKLVVSLGVELPADAAQAKQPEAAAGSEHTPGEGENSQQIINKIQDIISEIKENTEQPSHNHAGDHLNCCMGKFEVV", "length": 795 }, "evidence": [ { "id": "A0A3Q1LTM9", "url": "https://omabrowser.org/oma/group/A0A3Q1LTM9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi cisterna membrane", "id": "GO:0032580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM9" } ], "pmid": "" }, { "name": "cis-Golgi network", "id": "GO:0005801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005801", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM9" } ], "pmid": "" }, { "name": "Golgi cis cisterna", "id": "GO:0000137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000137", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "Golgi organization", "id": "GO:0007030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" }, { "start_pos": 523, "end_pos": 525, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LTM9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1032, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LTM9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LTM9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LTM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTM9" }, { "id": "PF15070", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15070" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Golgin subfamily A conserved", "eco_id": "ECO_0000259", "start_pos": 414, "end_pos": 938, "start_aa": "Gln", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 105 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 }, { "start_pos": 204, "end_pos": 206 }, { "start_pos": 51, "end_pos": 53 }, { "start_pos": 523, "end_pos": 525 }, { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LTT3-1", "uniprot_ac": "A0A3Q1LTT3", "uniprot_id": "A0A3Q1LTT3_BOVIN", "mass": { "chemical_mass": 148991.0, "monoisotopic_mass": 148991.0 }, "refseq": { "ac": "XP_059741679", "name": "neurabin-1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741679" }, "gene_names": [ { "name": "PPP1R9A", "type": "recommended", "evidence": [ { "id": "A0A3Q1LTT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT3" } ] }, { "name": "PPP1R9A", "type": "synonym", "evidence": [ { "id": "XP_059741679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741679" } ] } ], "protein_names": [ { "name": "Neurabin-1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LTT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT3/entry#names_and_taxonomy" } ] }, { "name": "Neurabin-I", "type": "synonym", "evidence": [ { "id": "A0A3Q1LTT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT3/entry#names_and_taxonomy" } ] }, { "name": "Neural tissue-specific F-actin-binding protein I", "type": "synonym", "evidence": [ { "id": "A0A3Q1LTT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT3/entry#names_and_taxonomy" } ] }, { "name": "Protein phosphatase 1 regulatory subunit 9A", "type": "synonym", "evidence": [ { "id": "A0A3Q1LTT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT3/entry#names_and_taxonomy" } ] }, { "name": "neurabin-1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059741679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741679" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTT3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPP1R9A", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT3", "locus": { "chromosome": "4", "start_pos": 12535306, "end_pos": 12191289, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024426", "url": "https://www.ensembl.org/id/ENSBTAG00000024426" } ] } } ], "crossref": [ { "id": "ENSBTAG00000024426", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024426", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06790", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06790", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09512", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09512", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539311", "url": "https://www.ncbi.nlm.nih.gov/gene/539311", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043446", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043446", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539311", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539311", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LTT3", "url": "https://www.orthodb.org/?gene=A0A3Q1LTT3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NNR8", "url": "https://www.orthodb.org/?gene=A0A3Q1NNR8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BC67", "url": "https://www.orthodb.org/?gene=E1BC67", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6R8E7", "url": "https://www.orthodb.org/?gene=F6R8E7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16154", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16154", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16154:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16154:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17817", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17817", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059741679", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741679", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTT3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTT3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NNR8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NNR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NNR8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NNR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC67", "url": "https://www.uniprot.org/uniprotkb/E1BC67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC67-1", "url": "https://www.uniprot.org/uniprotkb/E1BC67-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R8E7", "url": "https://www.uniprot.org/uniprotkb/F6R8E7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R8E7-1", "url": "https://www.uniprot.org/uniprotkb/F6R8E7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQMGMEPSENAAVMARTRGRGGPSSPQRRMKPREFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPKKEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHLKDSNSWSPPSKHSDDAEDAQKRSTSPGLEVASKSTSLASVPSEEAQQSKAAEDPASNREAPGRTDRDTPEEPGAESEAVPEPEIPSPQNEPSEDAEARLVESEAAMQQRRELAGGDFTSAEVSRFTCEKEVFEEPHHFGSSHVYMHSDYNVYRVRSRYNSDWGETGTEQEEQEDSDENNYCQPDVECSEIAGLPEEEDIPANRKIKFSSAPIKVFSTYSNEDYDRRNDEVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDENTVAELQGVSGNCNNNNNYFLKTGEYATDEEEDDVGPVLPGGDMAIEVFELPENEDVFSPSDLDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIEENKERMMKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLETEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTLENLDIKQTSCQDGLSQDFNEAVPETERLDSKVLKTRAQLSLKNRRQRPSRTRLYDSVSSTDGEDSLERKPSNSFCNHMHITKSLLPKGLRASPESDSGASSLSPVAGSVPLPSDHIAEFQEGPLYSEGEPSSSVGEDTSLSSPSKSDHDMEELPCHNQATTTKILQEKDGAKGPKSLRASSSLVVRGGKIKRKFVNLGAPLRKNSNKGKKWKEKEKEANRLSPGSRIFRCRLETWKPTPSSTAQASTRSTGLPFSWFNESRKGSYSFRNLPSSASPPQPSPEALISDKKGSKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLVLSSDEILDDGQSPKHSQYPNRAVHEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTSSQDRAVVKKKLKEMKVSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKTEKMAAATEGASEQ", "length": 1334, "header": "tr|A0A3Q1LTT3-1|A0A3Q1LTT3_BOVIN Isoform 1 of Neurabin-1 OS=Bos taurus OX=9913 GN=PPP1R9A PE=4 SV=3 CANONICAL=A0A3Q1LTT3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTT3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT3/entry", "sequence": { "sequence": "MLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQMGMEPSENAAVMARTRGRGGPSSPQRRMKPREFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPKKEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHLKDSNSWSPPSKHSDDAEDAQKRSTSPGLEVASKSTSLASVPSEEAQQSKAAEDPASNREAPGRTDRDTPEEPGAESEAVPEPEIPSPQNEPSEDAEARLVESEAAMQQRRELAGGDFTSAEVSRFTCEKEVFEEPHHFGSSHVYMHSDYNVYRVRSRYNSDWGETGTEQEEQEDSDENNYCQPDVECSEIAGLPEEEDIPANRKIKFSSAPIKVFSTYSNEDYDRRNDEVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDENTVAELQGVSGNCNNNNNYFLKTGEYATDEEEDDVGPVLPGGDMAIEVFELPENEDVFSPSDLDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIEENKERMMKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLETEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTLENLDIKQTSCQDGLSQDFNEAVPETERLDSKVLKTRAQLSLKNRRQRPSRTRLYDSVSSTDGEDSLERKPSNSFCNHMHITKSLLPKGLRASPESDSGASSLSPVAGSVPLPSDHIAEFQEGPLYSEGEPSSSVGEDTSLSSPSKSDHDMEELPCHNQATTTKILQEKDGAKGPKSLRASSSLVVRGGKIKRKFVNLGAPLRKNSNKGKKWKEKEKEANRLSPGSRIFRCRLETWKPTPSSTAQASTRSTGLPFSWFNESRKGSYSFRNLPSSASPPQPSPEALISDKKGSKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLVLSSDEILDDGQSPKHSQYPNRAVHEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTSSQDRAVVKKKLKEMKVSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKTEKMAAATEGASEQ", "length": 1334, "header": "tr|A0A3Q1LTT3-1|A0A3Q1LTT3_BOVIN Isoform 1 of Neurabin-1 OS=Bos taurus OX=9913 GN=PPP1R9A PE=4 SV=3 CANONICAL=A0A3Q1LTT3-1" }, "locus": { "chromosome": "4", "start_pos": 12534302, "end_pos": 12193760, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068314.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068314.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058563.3", "url": "https://www.ensembl.org/id/ENSBTAP00000058563.3" } ] } }, { "isoform_ac": "A0A3Q1NNR8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NNR8/entry", "sequence": { "sequence": "MLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQMGMEPSENAAVMARTRGRGGPSSPQRRMKPREFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPKKEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHLKDSNSWSPPSKHSDDAEDAQKRSTSPGLEVASKSTSLASVPSEEAQQSKAAEDPASNREAPGRTDRDTPEEPGAESEAVPEPEIPSPQNEPSEDAEARLVESEAAMQQRRELAGGDFTSAEVSRFTCEKEVFEEPHHFGSSHVYMHSDYNVYRVRSRYNSDWGETGTEQEEQEDSDENNYCQPDVECSEIAGLPEEEDIPANRKIKFSSAPIKVFSTYSNEDYDRRNDEVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDDVGPVLPGGDMAIEVFELPENEDVFSPSDLDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIEENKERMMKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLETEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTLENLDIKQTSCQDGLSQDFNEAVPETERLDSKVLKTRAQLSLKNRRQRPSRTRLYDSVSSTDGEDSLERKPSNSFCNHMHITKSLLPKGLRASPESDSGASSLSPVAGSVPLPSDHIAEFQEGPLYSEGEPSSSVGEDTSLSSPSKSDHDMEELPCHNQATTTKILQEKDGAKGPKSLRASSSLVVRGGKIKRKFVNLGAPLRKNSNKGKKWKEKEKEANRLSPGSRIFRCRLETWKPTPSSTAQASTRSTGLPFSWFNESRKGSYSFRNLPSSASPPQPSPEALISDKKGSKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLVLSSDEILDDGQSPKHSQYPNRAVHEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTSSQDRAVVKKKLKEMKVSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKTEKMAAATEGASEQ", "length": 1312, "header": "tr|A0A3Q1NNR8-1|A0A3Q1LTT3_BOVIN Computationally mapped isoform of Neurabin-1 OS=Bos taurus OX=9913 GN=PPP1R9A PE=4 SV=2 CANONICAL=A0A3Q1LTT3-1" }, "locus": { "chromosome": "4", "start_pos": 12534302, "end_pos": 12193760, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086018.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086018.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074564.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074564.2" } ] } }, { "isoform_ac": "E1BC67-1", "url": "https://www.uniprot.org/uniprotkb/E1BC67/entry", "sequence": { "sequence": "MLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQMGMEPSENAAVMARTRGRGGPSSPQRRMKPREFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPKKEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHLKDSNSWSPPSKHSDDAEDAQKRSTSPGLEVASKSTSLASVPSEEAQQSKAAEDPASNREAPGRTDRDTPEEPGAESEAVPEPEIPSPQNEPSEDAEARLVESEAAMQQRRELAGGDFTSAEVSRFTCEKEVFEEPHHFGSSHVYMHSDYNVYRVRSRYNSDWGETGTEQEEQEDSDENNYCQPDVECSEIAGLPEEEDIPANRKIKFSSAPIKVFSTYSNEDYDRRNDEVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDETGEYATDEEEDDVGPVLPGGDMAIEVFELPENEDVFSPSDLDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIEENKERMMKLESYWIEAQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKAHLVEVQGLQVRIRDLETEVFRLLKQNGTQVNNNNNIFERRTSLGEVSKGDTLENLDIKQTSCQDGLSQDFNEAVPETERLDSKVLKTRAQLSLKNRRQRPSRTRLYDSVSSTDGEDSLERKNFTFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLVLSSDESLDMIDDEILDDGQSPKHSQYPNRAVHEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTSSQDRAVVKKKLKEMKVSLEKARKAQEKMEKQREKLRRKEQEQMQRKSKKTEKMAAATEGASEQ", "length": 1097, "header": "tr|E1BC67-1|A0A3Q1LTT3_BOVIN Computationally mapped isoform of Neurabin-1 OS=Bos taurus OX=9913 GN=PPP1R9A PE=4 SV=3 CANONICAL=A0A3Q1LTT3-1" }, "locus": { "chromosome": "4", "start_pos": 12534302, "end_pos": 12193760, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061346.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061346.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053750.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053750.4" } ] } }, { "isoform_ac": "F6R8E7-1", "url": "https://www.uniprot.org/uniprotkb/F6R8E7/entry", "sequence": { "sequence": 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"https://www.uniprot.org/uniprotkb/A0ABZ3NNI7/entry", "sequence": { "sequence": "MPGLARRTWRYCQKTTVCTVLTLRGMITILKTLFAGSSSREPSTCPTDHGGARAACVGCFSAPSRVRLRALKESNPWEFLPLGASCCSLLARITSPELSLHQPPLPRAGSILGKISARGEVWELFSREHGGSLLFAGSGKGDHCKLRGRCSWSCDPAAQPGVGWVWRECRESWAGRQRRAPERAPALRRASPAVGEARPAAAADRGRARARESSGSPQPHLRGRPAQDSLPGRAGYEVRGSGCGCRRGPARATSSPRGHRWKMSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES", "length": 622, "header": "tr|A0ABZ3NNI7-1|A0ABZ3NNI7_BOVIN Computationally mapped isoform of Mitogen-activated protein kinase 14 OS=Bos taurus OX=9913 GN=MAPK14 PE=3 SV=1 CANONICAL=A0A3Q1LTT9-1" }, "locus": { "chromosome": "23", "start_pos": 10042817, "end_pos": 9967905, "strand": "-", 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[ { "database": "UniProtKB", "id": "A0A3Q1LTT9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTT9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTT9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTT9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTT9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ], "pmid": "" }, { "name": "p38MAPK cascade", "id": "GO:0038066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038066", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTT9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 14, "end_pos": 16, "annotation": "n_glycosylation_sequon" }, { "start_pos": 201, "end_pos": 203, "annotation": "n_glycosylation_sequon" }, { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-1247960", "name": "Activation of p38 MAPK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5E9X2-1", "G3X793-1", "A0A3Q1LTT9-1" ], "evidence": [ { "id": "R-BTA-1247960", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1247960" } ] }, { "id": "R-BTA-168053", "name": "Phosphorylated MAPKs phosphorylate ATF-2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-450336" ], "output_participant_list": [ "R-BTA-450243" ], "enzyme_list": [ "G3X793-1", "P46196-1", "A0A3Q1LTT9-1", "A0AAA9S472-1", "E1B8P9-1", "A0A3Q1LJU7-1" ], "evidence": [ { "id": "R-BTA-168053", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-168053" } ] }, { "id": "R-BTA-187688", "name": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SYZ2-1", "G3X793-1", "A0A3Q1M614-1", "A0A3Q1LTT9-1" ], "evidence": [ { "id": "R-BTA-187688", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-187688" } ] }, { "id": "R-BTA-198669", "name": "p38MAPK phosphorylates MSK1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-198657" ], "output_participant_list": [ "R-BTA-198683" ], "enzyme_list": [ "G3X793-1", "A0AAA9T7Z7-1", "A0A3Q1LTT9-1" ], "evidence": [ { "id": "R-BTA-198669", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198669" } ] }, { "id": "R-BTA-3229102", "name": "p-MAPKAPK3 phosphorylates BMI1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SYZ2-1", "G3X793-1", "A0A3Q1LTT9-1" ], "evidence": [ { "id": "R-BTA-3229102", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3229102" } ] }, { "id": "R-BTA-3238999", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-ALL-29358" ], "output_participant_list": [], "enzyme_list": [ "Q5E9X2-1", "G3X793-1", "A0A3Q1LTT9-1", "F1MH23-1" ], "evidence": [ { "id": "R-BTA-3238999", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3238999" } ] }, { "id": "R-BTA-3239014", "name": "MAPKAPK5 phosphorylates TP53", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3X793-1", "A0A3Q1LTT9-1", "F1MH23-1" ], "evidence": [ { "id": "R-BTA-3239014", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3239014" } ] }, { "id": "R-BTA-3239019", "name": "Active p38 MAPK phosphorylates MAPKAPK5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3X793-1", "A0A3Q1LTT9-1", "F1MH23-1" ], "evidence": [ { "id": "R-BTA-3239019", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3239019" } ] }, { "id": "R-BTA-428941", "name": "P2Y purinoceptor 1 activates MAP kinase p38 alpha", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LTT9-1" ], "evidence": [ { "id": "R-BTA-428941", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-428941" } ] }, { "id": "R-BTA-428961", "name": "Phosphorylation of cPLA2 by MAPK p38 alpha", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-BTA-378502" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LTT9-1" ], "evidence": [ { "id": "R-BTA-428961", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-428961" } ] }, { "id": "R-BTA-432148", "name": "Fgr may phosphorylate p38 MAPK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-BTA-428933" ], "output_participant_list": [ "R-BTA-428935" ], "enzyme_list": [ "A0A3Q1LTT9-1" ], "evidence": [ { "id": "R-BTA-432148", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432148" } ] }, { "id": "R-BTA-448955", "name": "Phosphorylation of MEF2 proteins by p38", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3X793-1", "A0A3Q1LTT9-1" ], "evidence": [ { "id": "R-BTA-448955", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-448955" } ] }, { "id": "R-BTA-448958", "name": "Nuclear translocation of p38 MAPK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3X793-1", "Q2KJ93-1", "A0A3Q1LTT9-1", "A0A3Q1LI98-1" ], "evidence": [ { "id": "R-BTA-448958", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-448958" } ] }, { "id": "R-BTA-450222", "name": "Active p38 MAPK phosphorylates MAPKAPK2 or 3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SYZ2-1", "G3X793-1", "A0A3Q1M614-1", "A0A3Q1LTT9-1" ], "evidence": [ { "id": "R-BTA-450222", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450222" } ] }, { "id": "R-BTA-450257", "name": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SYZ2-1", "G3X793-1", "A0A3Q1M614-1", "A0A3Q1LTT9-1" ], "evidence": [ { "id": "R-BTA-450257", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450257" } ] }, { "id": "R-BTA-450333", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3SYZ2-1", "Q5E9X2-1", "G3X793-1", "A0A3Q1M614-1", "A0A3Q1LTT9-1" ], "evidence": [ { "id": "R-BTA-450333", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-450333" } ] }, { "id": "R-BTA-5218804", "name": "p38 MAPK activation by VEGFR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M0G8-1", "A0AAA9SPC9-1", "G3X793-1", "Q2KJ93-1", "A0A3Q1LTT9-1", "A0JNB0-1" ], "evidence": [ { "id": "R-BTA-5218804", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5218804" } ] }, { "id": "R-BTA-6798748", "name": "Exocytosis of secretory granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, secretory granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P19120-1", "P68401-1", "A0JNA3-1", "F1MMD5-1", "A0AAA9S4U4-1", "P80177-1", "Q0II59-1", "Q0VCM4-1", "Q3SWY3-1", "Q3SYU2-1", "F1MHT1-1", "A0AAA9RV00-1", "A0ABI0P3F2-1", "P62935-1", "P68103-1", "Q3T0Q4-1", "A0A452DJA8-1", "E1BNY9-1", "A0A3Q1LMV5-1", "A0A3Q1LTT9-1", "A1A4J1-1", "F1MQ78-1", "G3X757-1", "P00432-1", "Q76LV2-1", "A0A140T8A5-1", "A0A3Q1LR63-1", "Q56JW4-1", "Q3T0A3-1", "Q3ZBD7-1", "Q58DK5-1", "Q3SZ62-1", "Q3T0V9-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6798748", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798748" } ] }, { "id": "R-BTA-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, ficolin-1-rich granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P19120-1", "P68401-1", "P80227-1", "A0JNA3-1", "F1MMD5-1", "Q32PF2-1", "Q3SZH7-1", "A0AAA9S4U4-1", "A0AAA9S9V5-1", "P07688-1", "O46414-1", "P25326-1", "P80177-1", "Q0VCM4-1", "Q3SWY3-1", "Q3SYU2-1", "F1MHT1-1", "F1MMR6-1", "A0ABI0NJH4-1", "A0AAA9RV00-1", "A0ABI0P3F2-1", "P05689-1", "P46196-1", "P52176-1", "P62935-1", "P68103-1", "Q17QB3-1", "Q3T0Q4-1", "Q27970-1", "A0A452DJA8-1", "E1BNY9-1", "A0A3Q1LMV5-1", "A0A3Q1LTT9-1", "A0AAA9SYX5-1", "A1A4J1-1", "E1BB52-1", "F1MQ78-1", "G3X757-1", "P00432-1", "Q76LV2-1", "A0A140T8A5-1", "A0A3Q1LR63-1", "A0A3Q1NDQ7-1", "Q3T0A3-1", "Q3ZBD7-1", "Q58DK5-1", "Q3SZ62-1", "Q3T0V9-1", "Q3ZCI9-1" ], "evidence": [ { "id": "R-BTA-6800434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6800434" } ] }, { "id": "R-BTA-9626880", "name": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3X793-1", "A0A3Q1LTT9-1" ], "evidence": [ { "id": "R-BTA-9626880", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9626880" } ] }, { "id": "R-BTA-9855910", "name": "USF1 is phosphorylated by p-MAPK14", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LTT9-1" ], "evidence": [ { "id": "R-BTA-9855910", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9855910" } ] }, { "id": "R-BTA-9942578", "name": "Phosphorylation of CDC25A by p38 MAPK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-BTA-9942581" ], "enzyme_list": [ "A7MBD1-1", "G3X793-1", "A0A3Q1LTT9-1" ], "evidence": [ { "id": "R-BTA-9942578", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9942578" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29358", "participant_name": "ATP [nucleoplasm]", "crossref": [ { "id": "30616", "database": "ChEBI", "url": "" }, { "id": "ZINC000004261765", "database": "ZINC", "url": "" }, { "id": "C00002", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-BTA-198657", "participant_name": "RPS6KA5 [nucleoplasm]", "crossref": [ { "id": "E1BN61", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000010906", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000014487", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000014487", "database": "ENSEMBL", "url": "" }, { "id": "NP_001178952.1", "database": "RefSeq", "url": "" }, { "id": "34144", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-198683", "participant_name": "phospho-p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]", "crossref": [ { "id": "ENSBTAT00000014487", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000010906", "database": "ENSEMBL", "url": "" }, { "id": "34144", "database": "VGNC", "url": "" }, { "id": "E1BN61", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000014487", "database": "ENSEMBL", "url": "" }, { "id": "NP_001178952.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-378502", "participant_name": "PLA2G4A [cytosol]", "crossref": [ { "id": "A4IFJ5", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000013298", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000017685", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000017685", "database": "ENSEMBL", "url": "" }, { "id": "HMDBP12174", "database": "HMDB Protein", "url": "" }, { "id": "A4IFJ5", "database": "PRO", "url": "" }, { "id": "NP_001069332.1", "database": "RefSeq", "url": "" }, { "id": "XP_059731388.1", "database": "RefSeq", "url": "" }, { "id": "32960", "database": "VGNC", "url": "" }, { "id": "PA24A_BOVIN", "database": "ZINC - Predictions - Purchasable", "url": "" }, { "id": "PA24A_BOVIN", "database": "ZINC - Substances", "url": "" }, { "id": "A4IFJ5", "database": "ZINC target", "url": "" } ] }, { "participant_id": "R-BTA-428933", "participant_name": "MAPK14 [cytosol]", "crossref": [ { "id": "A0A3Q1LTT9", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000020783", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000058569", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000073013", "database": "ENSEMBL", "url": "" }, { "id": "31216", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-428935", "participant_name": "phospho-p-T180,Y182-MAPK14 [cytosol]", "crossref": [ { "id": "ENSBTAT00000073013", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000020783", "database": "ENSEMBL", "url": "" }, { "id": "A0A3Q1LTT9", "database": "UniProt", "url": "" }, { "id": "31216", "database": "VGNC", "url": "" }, { "id": "ENSBTAP00000058569", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-450243", "participant_name": "phospho-p-T69,T71-ATF2 [nucleoplasm]", "crossref": [ { "id": "26240", "database": "VGNC", "url": "" }, { "id": "F1N177", "database": "UniProt", "url": "" } ] }, { "participant_id": "R-BTA-450336", "participant_name": "ATF2 [nucleoplasm]", "crossref": [ { "id": "F1N177", "database": "UniProt", "url": "" }, { "id": "26240", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-9942581", "participant_name": "phospho-CDC25A [nucleoplasm]", "crossref": [ { "id": "ENSBTAT00000099007", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000009586", "database": "ENSEMBL", "url": "" }, { "id": "27062", "database": "VGNC", "url": "" }, { "id": "A7MBD1", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000098992", "database": "ENSEMBL", "url": "" }, { "id": "NP_001094570.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T8A5", "gene_name": "IDH1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] } ] }, { "uniprot_ac": "A0A3Q1LI98", "gene_name": "ABL1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI98" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1LI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI98" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LMV5", "gene_name": "LOC281806", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] } ] }, { "uniprot_ac": "A0A3Q1LR63", "gene_name": "HK3", "activity": [ { "ec_number": "2.7.1.1", "activity": "D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR63" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR63" } ] } ] }, { "uniprot_ac": "A0A3Q1LTT9", "gene_name": "MAPK14", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LTT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" } ] } ] }, { "uniprot_ac": "A0A3Q1M0G8", "gene_name": "PAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M0G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0G8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M0G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0G8" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1NDQ7", "gene_name": "GLB1", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] } ] }, { "uniprot_ac": "A0A452DJA8", "gene_name": "PNP", "activity": [ { "ec_number": "2.4.2.1", "activity": "adenosine + phosphate = alpha-D-ribose 1-phosphate + adenine.", "evidence": [ { "id": "A0A452DJA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DJA8" } ] }, { "ec_number": "2.4.2.1", "activity": "", "evidence": [ { "id": "A0A452DJA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DJA8" } ] } ] }, { "uniprot_ac": "A0AAA9RV00", "gene_name": "PPIE", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0AAA9RV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV00" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0AAA9RV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RV00" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4U4", "gene_name": "ALDOC", "activity": [ { "ec_number": "4.1.2.13", "activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.", "evidence": [ { "id": "A0AAA9S4U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4U4" } ] }, { "ec_number": "4.1.2.13", "activity": "", "evidence": [ { "id": "A0AAA9S4U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4U4" } ] } ] }, { "uniprot_ac": "A0AAA9S9V5", "gene_name": "CANT1", "activity": [ { "ec_number": "3.6.1.6", "activity": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ] }, { "ec_number": "3.6.1.6", "activity": "", "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ] } ] }, { "uniprot_ac": "A0AAA9SPC9", "gene_name": "KDR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SPC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPC9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SPC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPC9" } ] } ] }, { "uniprot_ac": "A0AAA9SYX5", "gene_name": "KCMF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9SYX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9SYX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYX5" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0ABI0NJH4", "gene_name": "GNS", "activity": [ { "ec_number": "3.1.6.14", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] }, { "ec_number": "3.1.6.14", "activity": "", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0JNA3", "gene_name": "IMPDH1", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] } ] }, { "uniprot_ac": "A0JNB0", "gene_name": "FYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0JNB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNB0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0JNB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNB0" } ] } ] }, { "uniprot_ac": "A1A4J1", "gene_name": "PFKL", "activity": [ { "ec_number": "2.7.1.11", "activity": "beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+).", "evidence": [ { "id": "A1A4J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4J1" } ] }, { "ec_number": "2.7.1.11", "activity": "", "evidence": [ { "id": "A1A4J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4J1" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MHT1", "gene_name": "AGL", "activity": [ { "ec_number": "2.4.1.25", "activity": "Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "3.2.1.33", "activity": "Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "3.2.1.33", "activity": "", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "2.4.1.25", "activity": "", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMR6", "gene_name": "CTSD", "activity": [ { "ec_number": "3.4.23.5", "activity": "Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.", "evidence": [ { "id": "F1MMR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMR6" } ] }, { "ec_number": "3.4.23.5", "activity": "", "evidence": [ { "id": "F1MMR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMR6" } ] } ] }, { "uniprot_ac": "F1MQ78", "gene_name": "ALOX5", "activity": [ { "ec_number": "1.13.11.34", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O.", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.12", "activity": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate.", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.34", "activity": "", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] }, { "ec_number": "1.13.11.12", "activity": "", "evidence": [ { "id": "F1MQ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ78" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "G3X793", "gene_name": "MAPK11", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3X793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X793" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G3X793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X793" } ] } ] }, { "uniprot_ac": "O46414", "gene_name": "FTH1", "activity": [ { "ec_number": "1.16.3.1", "activity": "4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O.", "evidence": [ { "id": "O46414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46414" } ] }, { "ec_number": "1.16.3.1", "activity": "", "evidence": [ { "id": "O46414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46414" } ] } ] }, { "uniprot_ac": "P00432", "gene_name": "CAT", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = O2 + 2 H2O.", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] } ] }, { "uniprot_ac": "P05689", "gene_name": "CTSZ", "activity": [ { "ec_number": "3.4.18.1", "activity": "Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.", "evidence": [ { "id": "P05689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05689" } ] }, { "ec_number": "3.4.18.1", "activity": "", "evidence": [ { "id": "P05689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05689" } ] } ] }, { "uniprot_ac": "P07688", "gene_name": "CTSB", "activity": [ { "ec_number": "3.4.22.1", "activity": "Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.", "evidence": [ { "id": "P07688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07688" } ] }, { "ec_number": "3.4.22.1", "activity": "", "evidence": [ { "id": "P07688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07688" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P25326", "gene_name": "CTSS", "activity": [ { "ec_number": "3.4.22.27", "activity": "Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.", "evidence": [ { "id": "P25326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25326" } ] }, { "ec_number": "3.4.22.27", "activity": "", "evidence": [ { "id": "P25326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25326" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P52176", "gene_name": "MMP9", "activity": [ { "ec_number": "3.4.24.35", "activity": "Cleavage of gelatin types I and V and collagen types IV and V.", "evidence": [ { "id": "P52176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52176" } ] }, { "ec_number": "3.4.24.35", "activity": "", "evidence": [ { "id": "P52176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52176" } ] } ] }, { "uniprot_ac": "P62935", "gene_name": "PPIA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62935" } ] } ] }, { "uniprot_ac": "P68103", "gene_name": "EEF1A1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P68103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68103" } ] } ] }, { "uniprot_ac": "P68401", "gene_name": "PAFAH1B2P68402", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P68401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68401" } ] } ] }, { "uniprot_ac": "P80177", "gene_name": "MIF", "activity": [ { "ec_number": "5.3.2.1", "activity": "3-phenylpyruvate = enol-phenylpyruvate.", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] }, { "ec_number": "5.3.3.12", "activity": "L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] }, { "ec_number": "5.3.2.1", "activity": "", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] }, { "ec_number": "5.3.3.12", "activity": "", "evidence": [ { "id": "P80177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80177" } ] } ] }, { "uniprot_ac": "P80227", "gene_name": "APEH", "activity": [ { "ec_number": "3.4.19.1", "activity": "Internal cleavage of oxidized and glycated proteins.", "evidence": [ { "id": "P80227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80227" } ] }, { "ec_number": "3.4.19.1", "activity": "", "evidence": [ { "id": "P80227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80227" } ] } ] }, { "uniprot_ac": "Q0II59", "gene_name": "PDXK", "activity": [ { "ec_number": "2.7.1.35", "activity": "pyridoxine + ATP = pyridoxine 5'-phosphate + ADP + H(+).", "evidence": [ { "id": "Q0II59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II59" } ] }, { "ec_number": "2.7.1.35", "activity": "", "evidence": [ { "id": "Q0II59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II59" } ] } ] }, { "uniprot_ac": "Q0VCM4", "gene_name": "PYGL", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "Q0VCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCM4" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "Q0VCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCM4" } ] } ] }, { "uniprot_ac": "Q17QB3", "gene_name": "ASAH1", "activity": [ { "ec_number": "3.5.1.23", "activity": "an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid.", "evidence": [ { "id": "Q17QB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB3" } ] }, { "ec_number": "3.5.1.23", "activity": "", "evidence": [ { "id": "Q17QB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB3" } ] }, { "ec_number": "3.5.1.-", "activity": "", "evidence": [ { "id": "Q17QB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QB3" } ] } ] }, { "uniprot_ac": "Q27970", "gene_name": "CAPN1", "activity": [ { "ec_number": "3.4.22.52", "activity": "Broad endopeptidase specificity.", "evidence": [ { "id": "Q27970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27970" } ] }, { "ec_number": "3.4.22.52", "activity": "", "evidence": [ { "id": "Q27970", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q27970" } ] } ] }, { "uniprot_ac": "Q2KJ93", "gene_name": "CDC42", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q2KJ93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ93" } ] } ] }, { "uniprot_ac": "Q32PF2", "gene_name": "ACLY", "activity": [ { "ec_number": "2.3.3.8", "activity": "oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA.", "evidence": [ { "id": "Q32PF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF2" } ] }, { "ec_number": "2.3.3.8", "activity": "", "evidence": [ { "id": "Q32PF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF2" } ] } ] }, { "uniprot_ac": "Q3SWY3", "gene_name": "IMPDH2", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "Q3SWY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY3" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "Q3SWY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY3" } ] } ] }, { "uniprot_ac": "Q3SYU2", "gene_name": "EEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q3SYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYU2" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZ62", "gene_name": "PGAM1", "activity": [ { "ec_number": "5.4.2.11", "activity": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ] }, { "ec_number": "5.4.2.4", "activity": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ] }, { "ec_number": "5.4.2.4", "activity": "", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ] }, { "ec_number": "5.4.2.11", "activity": "", "evidence": [ { "id": "Q3SZ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ62" } ] } ] }, { "uniprot_ac": "Q3SZH7", "gene_name": "LTA4H", "activity": [ { "ec_number": "3.3.2.6", "activity": "leukotriene A4 + H2O = leukotriene B4.", "evidence": [ { "id": "Q3SZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZH7" } ] }, { "ec_number": "3.4.11.4", "activity": "Release of the N-terminal residue from a tripeptide.", "evidence": [ { "id": "Q3SZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZH7" } ] }, { "ec_number": "3.3.2.6", "activity": "", "evidence": [ { "id": "Q3SZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZH7" } ] } ] }, { "uniprot_ac": "Q3T0A3", "gene_name": "CFD", "activity": [ { "ec_number": "3.4.21.46", "activity": "Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.", "evidence": [ { "id": "Q3T0A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0A3" } ] }, { "ec_number": "3.4.21.46", "activity": "", "evidence": [ { "id": "Q3T0A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0A3" } ] } ] }, { "uniprot_ac": "Q3T0Q4", "gene_name": "NME2", "activity": [ { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] }, { "ec_number": "2.7.13.3", "activity": "", "evidence": [ { "id": "Q3T0Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0Q4" } ] } ] }, { "uniprot_ac": "Q3T0V9", "gene_name": "DERA", "activity": [ { "ec_number": "4.1.2.4", "activity": "2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.", "evidence": [ { "id": "Q3T0V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0V9" } ] }, { "ec_number": "4.1.2.4", "activity": "", "evidence": [ { "id": "Q3T0V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0V9" } ] } ] }, { "uniprot_ac": "Q3ZBD7", "gene_name": "GPI", "activity": [ { "ec_number": "5.3.1.9", "activity": "alpha-D-fructose 6-phosphate = beta-D-fructose 6-phosphate.", "evidence": [ { "id": "Q3ZBD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD7" } ] }, { "ec_number": "5.3.1.9", "activity": "", "evidence": [ { "id": "Q3ZBD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD7" } ] }, { "ec_number": "5.1.3.-", "activity": "", "evidence": [ { "id": "Q3ZBD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBD7" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] }, { "uniprot_ac": "Q56JW4", "gene_name": "APRT", "activity": [ { "ec_number": "2.4.2.7", "activity": "AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine.", "evidence": [ { "id": "Q56JW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ] }, { "ec_number": "2.4.2.7", "activity": "", "evidence": [ { "id": "Q56JW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q56JW4" } ] } ] }, { "uniprot_ac": "Q58DK5", "gene_name": "ALAD", "activity": [ { "ec_number": "4.2.1.24", "activity": "2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+).", "evidence": [ { "id": "Q58DK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DK5" } ] }, { "ec_number": "4.2.1.24", "activity": "", "evidence": [ { "id": "Q58DK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DK5" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q76LV2", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q76LV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q76LV2" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LTT9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 360, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LTT9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LTT9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LTT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTT9" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 24, 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Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9#function" }, { "database": "UniProtKB", "id": "ARBA00043899", "url": "https://www.uniprot.org/uniprotkb/ARBA00043899#function" }, { "database": "UniProtKB", "id": "A0A3Q1LWC2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWC2#function" } ] }, { "annotation": "The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017].", "evidence": [ { "database": "RefSeq", "id": "NP_001305900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305900" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OPRL1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9", "locus": { "chromosome": "13", "start_pos": 53778580, "end_pos": 53791161, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000049473", "url": "https://www.ensembl.org/id/ENSBTAG00000049473" } ] } } ], "crossref": [ { "id": "A0A3Q1LTY9", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LTY9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000049473", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049473", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15092", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15092", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100296381", "url": "https://www.ncbi.nlm.nih.gov/gene/100296381", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001420", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001420", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100296381", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296381", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VNICIWA", "url": "https://omabrowser.org/oma/group/VNICIWA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LTY9", "url": "https://www.orthodb.org/?gene=A0A3Q1LTY9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWC2", "url": "https://www.orthodb.org/?gene=A0A3Q1LWC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24229", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24229", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24229:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24229:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-375276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001305900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305900", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTY9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWC2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWC2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWC2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESLFPAPFWEVLYQEHLQGNLSLLSANHSLLPPHLLLNASHGAFLPLGLKVTILGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDVLLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAVCIFLFSFIIPVLIISICYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSGLNPILYAFLDENFKACFRKFCCASTLRREMQVSDRVRSIAKDVALAHKTAETVPRPA", "length": 370, "header": "tr|A0A3Q1LTY9-1|A0A3Q1LTY9_BOVIN Isoform 1 of Nociceptin receptor OS=Bos taurus OX=9913 GN=OPRL1 PE=3 SV=1 CANONICAL=A0A3Q1LTY9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTY9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9/entry", "sequence": { "sequence": "MESLFPAPFWEVLYQEHLQGNLSLLSANHSLLPPHLLLNASHGAFLPLGLKVTILGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDVLLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAVCIFLFSFIIPVLIISICYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSGLNPILYAFLDENFKACFRKFCCASTLRREMQVSDRVRSIAKDVALAHKTAETVPRPA", "length": 370, "header": "tr|A0A3Q1LTY9-1|A0A3Q1LTY9_BOVIN Isoform 1 of Nociceptin receptor OS=Bos taurus OX=9913 GN=OPRL1 PE=3 SV=1 CANONICAL=A0A3Q1LTY9-1" }, "locus": { "chromosome": "13", "start_pos": 53787771, "end_pos": 53779917, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070736.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070736.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058639.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058639.1" } ] } }, { "isoform_ac": "A0A3Q1LWC2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWC2/entry", "sequence": { "sequence": "MSACNHPLCFLHLIRLPGRSVQTGTHIQPHSSLLLNPYLTLKAIRKCISRSWRPGLFVRGVGMESLFPAPFWEVLYQEHLQGNLSLLSANHSLLPPHLLLNASHGAFLPLGLKVTILGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDVLLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAVCIFLFSFIIPVLIISICYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSGLNPILYAFLDENFKACFRKFCCASTLRREMQVSDRVRSIAKDVALAHKTAETVPRPA", "length": 432, "header": "tr|A0A3Q1LWC2-1|A0A3Q1LWC2_BOVIN Computationally mapped isoform of Nociceptin receptor OS=Bos taurus OX=9913 GN=OPRL1 PE=3 SV=1 CANONICAL=A0A3Q1LTY9-1" }, "locus": { "chromosome": "13", "start_pos": 53790125, "end_pos": 53779917, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084136.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084136.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061716.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061716.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100296381", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100296381", "resource": "KEGG Pathway" }, { "id": "R-BTA-375276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "resource": "Reactome", "description": "Peptide ligand-binding receptors" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "G3IBS6-1", "protein_name": "Nociceptin receptor", "gene_name": "Oprl1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MESLFPAPFWEVLYGSHFEGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAINVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPVQVFVLVQGLGVQPGSETAVATLRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLACKTSETVPRPA", "length": 367 }, "evidence": [ { "id": "A0A3Q1LTY9", "url": "https://omabrowser.org/oma/group/A0A3Q1LTY9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P35370-1", "protein_name": "Nociceptin receptor", "gene_name": "Oprl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGLGCKTSETVPRPA", "length": 367 }, "evidence": [ { "id": "A0A3Q1LTY9", "url": "https://omabrowser.org/oma/group/A0A3Q1LTY9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P35377-1", "protein_name": "Nociceptin receptor", "gene_name": "Oprl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTSETVPRPA", "length": 367 }, "evidence": [ { "id": "A0A3Q1LTY9", "url": "https://omabrowser.org/oma/group/A0A3Q1LTY9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P41146-1", "protein_name": "Nociceptin receptor", "gene_name": "OPRL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA", "length": 370 }, "evidence": [ { "id": "A0A3Q1LTY9", "url": "https://omabrowser.org/oma/group/A0A3Q1LTY9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GF58-1", "protein_name": "Nociceptin receptor", "gene_name": "OPRL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDPLFPAHILEDPDLRKLLNDSSMLNLSFLPSNWFNNGTGDSFLPLSIKITIVVVYSIVCIVGLVGNCSVMYVIVRFTKMKTATNIYIFNLALADTLCLMTLPFQGTDTFLGFWPFGNVLCKIAISIDYYNMFTSTFTLTMMSVDRYIAICHPIKALDIRTPHKAKVVNVCIWALASVFGIPAMVMGSAENENNEIDCLIKLPSPVDYWDPVFGICVFLFSFMIPVLIITICYSLMIRRLKNVRVLSGSKEKDRNLRRITRMVLVVVAVFIICWTPIQIFVLVQCLGAKAESELELAISCFCTALGYANSSLNPVLYAFLDENFKACFKKFCFPTAFRTELQMSNRMCSIAKDVAYACKNSEGTNNPA", "length": 368 }, "evidence": [ { "id": "A0A3Q1LTY9", "url": "https://omabrowser.org/oma/group/A0A3Q1LTY9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "nociceptin receptor activity", "id": "GO:0001626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001626", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9" } ], "pmid": "" }, { "name": "neuropeptide binding", "id": "GO:0042923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042923", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9" } ], "pmid": "" }, { "name": "synaptic membrane", "id": "GO:0097060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097060", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9" } ], "pmid": "" }, { "name": "sensory perception of pain", "id": "GO:0019233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019233", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9" } ], "pmid": "" }, { "name": "adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "id": "GO:0007193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007193", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9" } ], "pmid": "" }, { "name": "phospholipase C-activating G protein-coupled receptor signaling pathway", "id": "GO:0007200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007200", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9" } ], "pmid": "" }, { "name": "neuron-neuron synaptic transmission", "id": "GO:0007270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 21, "end_pos": 23, "annotation": "n_glycosylation_sequon" }, { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LTY9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 370, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LTY9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LTY9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LTY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTY9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 68, "end_pos": 319, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 21, "end_pos": 23 }, { "start_pos": 28, "end_pos": 30 }, { "start_pos": 39, "end_pos": 41 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", 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"sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LU21-1", "uniprot_ac": "A0A3Q1LU21", "uniprot_id": "A0A3Q1LU21_BOVIN", "mass": { "chemical_mass": 117987.0, "monoisotopic_mass": 117987.0 }, "refseq": { "ac": "NP_001192584", "name": "protein transport protein Sec24C", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192584" }, "gene_names": [ { "name": "SEC24C", "type": "recommended", "evidence": [ { "id": "A0A3Q1LU21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21" } ] }, { "name": "SEC24C", "type": "synonym", "evidence": [ { "id": "NP_001192584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192584" } ] } ], "protein_names": [ { "name": "SEC24 family, member C", "type": "synonym", "evidence": [ { "id": "NP_001192584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192584" } ] }, { "name": "SEC24 homolog C, COPII coat complex component", "type": "synonym", "evidence": [ { "id": "A0A3Q1LU21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21/entry#names_and_taxonomy" } ] }, { "name": "SEC24 related gene family, member C", "type": "synonym", "evidence": [ { "id": "NP_001192584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192584" } ] }, { "name": "protein transport protein Sec24C", "type": "synonym", "evidence": [ { "id": "NP_001192584", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192584" } ] } ], "function": [], "disease": [], "snv": [], 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"https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01479", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509488", "url": "https://www.ncbi.nlm.nih.gov/gene/509488", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006895", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006895", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012990", "database": "InterPro", "categories": [ "Protein Classification" 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"categories": [ "Protein Classification" ] }, { "id": "bta:509488", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509488", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "INPFMTF", "url": "https://omabrowser.org/oma/group/INPFMTF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LU21", "url": "https://www.orthodb.org/?gene=A0A3Q1LU21", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BIU0", "url": "https://www.orthodb.org/?gene=E1BIU0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13803", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13803", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13803:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13803:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00626", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00626", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04810", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04810", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04811", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04811", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04815", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04815", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08033", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08033", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2132295", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5694530", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5694530", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983170", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983170", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192584", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LU21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LU21-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIU0", "url": "https://www.uniprot.org/uniprotkb/E1BIU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BIU0-1", "url": "https://www.uniprot.org/uniprotkb/E1BIU0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNVNQSAPPVPPFGQPQPVYPGYHQSSYGGQPGSTAAPTPYGAYNGPVPGYQQTPPPGVSRAPASSGAPPASTAQGPCGQTAYGQFGQGDVQNGPSSGVQMQRLPGSQPFASAPLAPVVSQPAVLQPYGPPPTSAQVTAQLAGMQISGAVAPAPPASGLGYGSPTSLASASGSFPNSGLYGSYPQGQAPPLGQGHPGAQPPQRSVPPQASSFTPPASGGPRMPSMTGPLLPGQSFGGPPVSQPNHVSSPPPQALPPGTQMTGPPGPPPPMHSSQQPGYQLQQNGSFGPARGPQSNYGSPYPGAATFGSQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGSEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPFMQFVEGGRRFQCCFCSCINDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPIPPAFIFMIDVSYNAVRSGLVRLLCEELKSLLDFLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVGDMFVPLLDGFLVNVSESRAVITSLLDQIPEMFADTRETETVFAPVVQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQSGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYACFQVENDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEENGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRGVLSSPVKTVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSEVLQPGAEVTTDDRAYVRQLVTSMDVAETNVFFYPRLLPLTKSPIENTTEPPAVRASEERLSNGDIYLLENGLNLFLWVGASVQQGVVQSLFGVSSFSQITSGLSVLPVLDNLLSKKVRGLIDSLRAQRSRYMKLIVVKQEDKLEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQLLS", "length": 1094, "header": "tr|A0A3Q1LU21-1|A0A3Q1LU21_BOVIN Isoform 1 of SEC24 homolog C, COPII coat complex component OS=Bos taurus OX=9913 GN=SEC24C PE=1 SV=1 CANONICAL=A0A3Q1LU21-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LU21-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21/entry", "sequence": { "sequence": "MNVNQSAPPVPPFGQPQPVYPGYHQSSYGGQPGSTAAPTPYGAYNGPVPGYQQTPPPGVSRAPASSGAPPASTAQGPCGQTAYGQFGQGDVQNGPSSGVQMQRLPGSQPFASAPLAPVVSQPAVLQPYGPPPTSAQVTAQLAGMQISGAVAPAPPASGLGYGSPTSLASASGSFPNSGLYGSYPQGQAPPLGQGHPGAQPPQRSVPPQASSFTPPASGGPRMPSMTGPLLPGQSFGGPPVSQPNHVSSPPPQALPPGTQMTGPPGPPPPMHSSQQPGYQLQQNGSFGPARGPQSNYGSPYPGAATFGSQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGSEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPFMQFVEGGRRFQCCFCSCINDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPIPPAFIFMIDVSYNAVRSGLVRLLCEELKSLLDFLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVGDMFVPLLDGFLVNVSESRAVITSLLDQIPEMFADTRETETVFAPVVQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQSGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYACFQVENDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEENGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRGVLSSPVKTVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSEVLQPGAEVTTDDRAYVRQLVTSMDVAETNVFFYPRLLPLTKSPIENTTEPPAVRASEERLSNGDIYLLENGLNLFLWVGASVQQGVVQSLFGVSSFSQITSGLSVLPVLDNLLSKKVRGLIDSLRAQRSRYMKLIVVKQEDKLEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQLLS", "length": 1094, "header": "tr|A0A3Q1LU21-1|A0A3Q1LU21_BOVIN Isoform 1 of SEC24 homolog C, COPII coat complex component OS=Bos taurus OX=9913 GN=SEC24C PE=1 SV=1 CANONICAL=A0A3Q1LU21-1" }, "locus": { "chromosome": "28", "start_pos": 29660832, "end_pos": 29641131, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079518.1", "url": "https://www.ensembl.org/id/ENSBTAT00000079518.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063998.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063998.1" } ] } }, { "isoform_ac": "E1BIU0-1", "url": "https://www.uniprot.org/uniprotkb/E1BIU0/entry", "sequence": { "sequence": "MNVNQSAPPVPPFGQPQPVYPGYHQSSYGGQPGSTAAPTPYGAYNGPVPGYQQTPPPGVSRAPASSGAPPASTAQGPCGQTAYGQFGQGDVQNGPSSGVQMQRLPGSQPFASAPLAPVVSQPAVLQPYGPPPTSAQVTAQLAGMQISGAVAPAPPASGLGYGSPTSLASASGSFPNSGLYGSYPQGQAPPLGQGHPGAQPPQRSVPPQASSFTPPASGGPRMPSMTGPLLPGQSFGGPPVSQPNHVSSPPPQALPPGTQMTGPPGPPPPMHSSQQPGYQLQQNGSFGPARGPQSNYGSPYPGAATFGSQPGPPQPLPPKRLDPDAIPSPQLNELPPQQKTRHRIDPDAIPSPIQVIEDDRNNRGSEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPFMQFVEGGRRFQCCFCSCINDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPIPPAFIFMIDVSYNAVRSGLVRLLCEELKSLLDFLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVGDMFVPLLDGFLVNVSESRAVITSLLDQIPEMFADTRETETVFAPVVQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQSGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYACFQVENDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEENGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRGVLSSPVKTVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSEVLQPGAEVTTDDRAYVRQLVTSMDVAETNVFFYPRLLPLTKSPIENTTEPPAVRASEERLSNGDIYLLENGLNLFLWVGASVQQGVVQSLFGVSSFSQITSGLSVLPVLDNLLSKKVRGLIDSLRAQRSRYMKLIVVKQEDKLEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQLLS", "length": 1117, "header": "tr|E1BIU0-1|E1BIU0_BOVIN Computationally mapped isoform of SEC24 homolog C, COPII coat complex component OS=Bos taurus OX=9913 GN=SEC24C PE=1 SV=2 CANONICAL=A0A3Q1LU21-1" }, "locus": { "chromosome": "28", "start_pos": 29660832, "end_pos": 29641131, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003616.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003616.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003616.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003616.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 133, "start_aa": "Thr", "end_pos": 133, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr133", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:509488", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509488", "resource": "KEGG Pathway" }, { "id": "R-BTA-204005", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204005", "resource": "Reactome", "description": "COPII-mediated vesicle transport" }, { "id": "R-BTA-2132295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "resource": "Reactome", "description": "MHC class II antigen presentation" }, { "id": "R-BTA-5694530", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5694530", "resource": "Reactome", "description": "Cargo concentration in the ER" }, { "id": "R-BTA-983170", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983170", "resource": "Reactome", "description": "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZQ28-1", "protein_name": "SEC24 homolog C, COPII coat complex component", "gene_name": "SEC24C", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNVNQSAPPVPPFGQPQPVYPGYHQSSYGGQQGSPAAPTPYGAYNGPVPGYQQAPPPGVSRAPPSSGAPPASTAQGPCGQNAYGQFGQGDVQNGPNSTVQMQRLPGSQPFGSAPLAPVVSQPAVLQPYGPPPTSAQVTAQLAGMQISGAVAPAPPPSGLGYGPPTSLASASGNFPNSGLYGSYPQGQAPPLGQAQGHPGAQPPQRSVPPQASSFTPPTSGGPRMPSMTGPHLPGQSFGGPPGSQPNHVSSPPPQALPSGSQMTGPPGPPPMHSSQQPGYQLQQNGSFGPSRGPQPNYGSPYPGAATFGSQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGSEPFVTGARGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPFMQFIEGGRRFQCCFCSCINDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRSGLVRLLCEELKSLLDFLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVGDMFVPLLDGFLVNVNESRAVITSLLDQIPEMFADTRETETVFAPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGAYQTLAKECVAQGCCIDLFLFPNQYVDVATLSVVPQLTGGSVYKYACFQVENDQERFLSDLRRDVQKVIGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRGVLNSPVKTVRDALITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVTTDDRTYVRQLVISMDVAETNVFFYPRLLPLTKSPIESTTEPPAVRASEERLSNGDIYLLENGLNLFLWVGASVQQGVVQSLFGVSSFSQITSGLSVLPVLDNLLSKKVRGLIDNLRAQRSRYMKLIVVKQEDKLEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQLLS", "length": 1095 }, "evidence": [ { "id": "A0A3Q1LU21", "url": "https://omabrowser.org/oma/group/A0A3Q1LU21/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "B5DEG8-1", "protein_name": "SEC24 homolog C, COPII coat complex component", "gene_name": "Sec24c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNVNQSAPPVPPFGQNQPIYPGYHQSNYGGQPGPAAPATPYGAYNGPVPGYQQAPPQGVPRAPPCSGAPPASAAQVPCGQTTYGQFGQGDIQNGPSSTAQMPRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQISGAVAQAPPPSGLGYGPPTSLASASGNFPNSGPYSTYPQSQAPPLSQAQGHPGVQPPLRSAPPLASSFTSPASGGPRMPSMPGPLPPGQGFGSLPVSQANRVSSPPAHALPPGTQMTGPPAPPPPMHSPQQPGYQLQQNGSFGPARGPQPNYESPYPGAPTFGTQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGSEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPLMTFIEGGRRFQCSFCSCINDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDYLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVADMFVPLLDGFLVNVSESRAVITSLLDQIPEMFADTRETETVFAPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGTYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYACFQVENDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRAVVSSPVKTVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVTTDDRAYVRQLVSSMDVAETNVFFYPRLLPLTKSPLDSTTEPPAVRASEERLSSGDIYLLENGLNLFVWVGASVQQGVVQSLFNVSSFSQITSGLSVLPVLDNPLSKKVRGLIDTLRAQRTRYMKLIVVKQEDKLEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQLLS", "length": 1095 }, "evidence": [ { "id": "A0A3Q1LU21", "url": "https://omabrowser.org/oma/group/A0A3Q1LU21/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3X972-1", "protein_name": "SEC24 homolog C, COPII coat complex component", "gene_name": "Sec24c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNVNQSAPPVPPYGQNQPIYPGYHQSSYGGQPGPAAPATPYGAYNGPVPGYQQAPPQGVPRAPPSSGAPPASAAQVPCGQTTYGQFGQGDIQNGPSSTAQMQRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAGMQISGAVAQAPPPSGLGYGPPTSLASASGNFPNSGPYGSYPQSQAPPLSQAQGHPGVQPPLRSAPPLASSFTSPASGGPQMPSMTGLLPPGQGFGSLPVNQANHVSSPPAPALPPGTQMTGPPVPPPPPMHSPQQPGYQLQQNGSFGPARGPQPNYESPYPGAPTFGSQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGSEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPLMTFIEGGRRFQCSFCSCVNDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDYLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVADMFVPLLDGFLVNVSESRAVITSLLDQIPEMFADTRETETVFAPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGTYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYACFQVENDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEENGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRAVLNSPVKTVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVTTDDRAYVRQLVSSMDVAETNVFFYPRLLPLTKSPLDSTAEPPAVRASEERLSSGDIYLLENGLNLFVWVGASVQQGVVQSLFNVSSFSQITSGLSVLPVLDNPLSKKVRGLIDSLRAQRMRYMKLIVVKQEDKLEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQLLS", "length": 1096 }, "evidence": [ { "id": "A0A3Q1LU21", "url": "https://omabrowser.org/oma/group/A0A3Q1LU21/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "M9PC99-1", "protein_name": "Secretory 24CD, isoform C", "gene_name": "Sec24CD", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNPNMYGPPPTQFQQQPQFGAPPPNSGGWPPQQQQLPQQQPPQQQLPPQQQQQQPQYGAPPPTSAASQPYLNGNYQQQLATSMGGLSVGGGVGGANPLKPPLPQGAPAAAAPPPTGFNQFNSNAAPPPTNNNNAAFGAPPPTQAGSYVNGALPPSSTPQSVASGINQMSLNSATLAGLPHMPPPKAATPGAAPGQPPIPAAGSTSQPPLPGQPPLPGQPPFSGQIPTSQPAPSPYGVPSSRPGQPQLPPGATPPTYTQPGLPPQQQQGIPPLQQPGIPQQQPGFPPQQPGLPPLSQPGLPPQPGAPYGAPQQGGYSGGFPGQAPGGFPGAPPPLPGQQAAAPPQFGAPQPGYPGQQPGYPPQPGQQPMPGYPPQPGQQLGGPGYPPQPGAGFPGQPGRPGFNQPPMPGAGNMYQQAPQARRLDPDQMPNPIQVMIENQRLSGGPFVTNQPGLLPPLVTTKFVVHDQGNSSPRFLRSSLYCIPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGEMGPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVHQNYYQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDQGQDKSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQEMFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAPGKLKNRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQADVDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGHFFMSNTTDVELASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGGSDMTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIHNVVPEETDLPTPVRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQSVFGVQGLQQIALERFNIVPETPLAKRIHGILEQIMKERSRYMRITWLRQNDKLESVFRHFLVEDRGTDGSASYVDFLCHMHKEIKDLLSXHAGYSGTYKPEQRWADSYSQNRARMRRLSSMRSRLGK", "length": 1231 }, "evidence": [ { "id": "A0A3Q1LU21", "url": "https://omabrowser.org/oma/group/A0A3Q1LU21/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P38810-1", "protein_name": "SED5-binding protein 3", "gene_name": "SFB3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSQQNILAASVSALSLDESTVHTGGASSKKSRRPHRAYHNFSSGTVPTLGNSPYTTPQLNQQDGFQQPQAFTPKQFGGFNNGSGSVMSTPVMVSQERFGASEASSPYGQSMLDMTAPQPTSHIVPTQRFEDQAQYLQRSFETCRDSVPPLPTTQFYCVDQGSCDPHLMSLSMYNIPESEHLRAATKLPLGLTIQPFSTLTPNDAEVPTIPLPMDGTPLRCRRCRAYANPKFQFTYDSSVICNICRVKMQVPGEHFAPMGPNGQRSDLNEKSELLHGTVDFLVPSIYNAIQEKELLPLHYVFLIDVSLLANENGSSLAMVEGVRSCIEYISDFQPNCEVAIIVYDNKLRFFNLRPDLDNAQEYIVSELDDVFLPFYNGLFVKPGNSMKIINDTLIKISGYISTDKYSHVPQVCYGSALQAAKLALDTVTGGQGGKIICSLNSLPTIGNGNLSLKRDNAHIAHVKCDNGFYKKLASDFLKSYISLDLYVTNAGFIDMATVGHPVEMTSGILKYYPHFQQETDAFTLVNDMVTNVSNIVGYQALLKVRCSTGLSVEQYYCDSSDNTDHDPIIPVLTRDTTLDVLLKYDSKIKTGTDVHFQTALLYTDIDGVRKVRSINTSGAVSNNIREIFKFINQNPVMRIMIKDVIKTLGDCDFVKIRRLIDDKMVEILTQYRGLVSSNSSTQLILPDSIKTLPAYMLAFEKSELMKPNAQSTRGNERIYDLLKYDSLNSAQLCYKLYPQIVPFHVLLEETDLTFYDANDKLLQINSSSINNLSVRASHSNFINGGCYLIFQGDTIYLWFNENTNRMLLQDLLSVDESLPVSQISLFSGTLPETGTSINQKASNVIKNWQQVVNKSSLPLVLLRPNVDQYYSNVMSQLLCEDKTVNRIESYDNYLVIMHKKIQEKLQKDDFIKVSTAATHENIHQKFVQF", "length": 929 }, "evidence": [ { "id": "A0A3Q1LU21", "url": "https://omabrowser.org/oma/group/A0A3Q1LU21/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P53992-1", "protein_name": "Protein transport protein Sec24C", "gene_name": "SEC24C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNVNQSVPPVPPFGQPQPIYPGYHQSSYGGQSGSTAPAIPYGAYNGPVPGYQQTPPQGMSRAPPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPSSTVQMQRLPGSQPFGSPLAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQASSFTPPASGGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQMTGPLGPLPPMHSPQQPGYQPQQNGSFGPARGPQSNYGGPYPAAPTFGSQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGTEPFVTGVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYVVDHGESGPLRCNRCKAYMCPFMQFIEGGRRFQCCFCSCINDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDFLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVADMFVPLLDGFLVNVNESRAVITSLLDQIPEMFADTRETETVFVPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGAYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVENDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRGVLNSPVKAVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVTTDDRAYVRQLVTSMDVTETNVFFYPRLLPLTKSPVESTTEPPAVRASEERLSNGDIYLLENGLNLFLWVGASVQQGVVQSLFSVSSFSQITSGLSVLPVLDNPLSKKVRGLIDSLRAQRSRYMKLTVVKQEDKMEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQLLS", "length": 1094 }, "evidence": [ { "id": "A0A3Q1LU21", "url": "https://omabrowser.org/oma/group/A0A3Q1LU21/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54Z72-1", "protein_name": "Uncharacterized protein", "gene_name": "sec24l", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSYPNQQQEQSGYPQQQQQGYPQQNQGGYPQQQQQQHQRGGYPQQGYPQQPQGYPQQNQGGYPQQPQTQQYNPYSQQTSPPTTTNSAPPTTNSAPLNPSVQQTSPPQSMTNNTGVYSQPPPTNQQQSPSKSQPINNNNMGGYPQQSSQSSPPPTSQQQQYQGGYPQQTGYSQQPQTNSLSSPTQPPPPITNNTSAPPQPTGYSQPPPMTNNTGYQQTTNTSQPPMNNYQQYSPNQPSGGNMYQQPQSQQSQQPQQPQQYQYNQQPPQQPYGQQQQQQQQQQQQQQQQQQQPPQQPYGQQPQQQQQWNSNPVPGLQNLSLGPNNQQPQQQYGQPQQQQYGQPPFVGQQQQQQQQPWQPQQPQQQPNQQQIEDNRINMSKVPSPTAILEQFNNYIYKTNSDVSPPPSTVQQLVIDQQNASPNFIRSTLYTIPENEDTLNLIHIPFAIHVQPLAYNGISGEVPVIRTPGGPIQCKRCHSYINPFNPFTNGGKYFTCRFCEFENQVPQEYFSATLPNGQRTDYEQRPELQRGSYDFIKTEANAAQVPGYVFVIEISQVTINSGIVENVINAIRRILNERYDSIPAKVGIITYDTEVHFWSFKPTYAYPQMKVLTADNVFVPVNDGFLVDYRESKQLMDFFFDNFKTFFKRPQPSNQPFAFGAAVQAAAMSLEKIGGRVFTFNTTLPKGSPGAIAKRVEKSIQPSPNGSQFYKTVATECVAKNVSVDLFVIPTEICDVPSYAQLATATGGHINLYNNYSAEVHSELLTSDIIHYVTMEFGFNATSKVRSSRGITVSAHYGNITEENGLIQMAGVTSDKSITSVLKYDDKLKPKSKAYIQFAMIYTNIKGETRIRIHNLRLSVDSVLTNLFKDSDLDSITTYFARVASKEVLTTTPTTVRSNTVDKGVDLLASYRKNCASDKKATQLILPEGIKLMPIYILSMMKTPCFRLSPDISQDLRYFYLNLYTSSAPSRIIPLIYPRTYPIHNLLPGDGYKHPNYDHIVLPSFIRLSADQISQNGIYIHEDGRQIMVWIQQFAATNYLRDLFGIESTFGYTNSKLSQLYHSLNGQNEYHQRIEAIIASITQLRGYKDRPVIFVVQGDPVDAHLRLQFHEDKGVDSVSYIDFLCQIHKQIQNKLS", "length": 1133 }, "evidence": [ { "id": "A0A3Q1LU21", "url": "https://omabrowser.org/oma/group/A0A3Q1LU21/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9M081-1", "protein_name": "Protein transport protein SEC24 C", "gene_name": "SEC24C", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVAPVPPGAPRPNSQQNSGPPNFYPGSQGNSNALADNMQNLSLNRPPPMMPGSGPRPPPPFGQSPQPFPQQSPSYGAPQRGPSPMSRPGPPAGMARPGGPPPVSQPAGFQSNVPLNRPTGPPSRQPSFGSRPSMPGGPVAQPAASSSGFPAFGPSGSVAAGPPPGSRPMAFGSPPPVGSGMSMPPSGMIGGPVSNGHQMVGSGGFPRGTQFPGAAVTTPQAPYVRPPSAPYARTPPQPLGSHSLSGNPPLTPFTAPSMPPPATFPGAPHGRPAVSGLPYGPPSAQVAPPLGFPGQMQPPRYGMGPLPNQSMTNIPTAMGQPGATVPGPSRIDPNQIPRPGSSSSPTVFETRQSNQANPPPPATSDYVVRDTGNCSPRYMRCTINQIPCTVDLLSTSGMQLALMVQPLALSHPSEEPIQVVDFGEGGPVRCSRCKGYINPFMKFIDQGRKFICNFCGYTDETPRDYHCNLGPDGRRRDVDERPELCRGTVEFVATKEYMVRDPMPAVYFFLIDVSMNAIQTGATAAACNAIQQVLSDLPEGPRTFVGIATFDSTIHFYNLKRALQQPLMLIVPDVQDVYTPLETDVVVQLSECRQHLELLLDSIPTMFQESKIPESAFGAAVKAAFLAMKSKGGKLMVFQSILCSVGVGALSSREAEGRANMSAGEKEAHKLLQPADKTLKTMAIEFAEYQVCVDIFITTQAYVDMASISVIPRTTGGQVYCYYPFSALSDPPKLYNDLKWNITRPQGFEAVMRVRCSQGIQVQEYSGNFCKRIPTDIDLPAHDDKLQDGAECAFQCALLYTTIYGERRIRVTTLSLSCTNMLSNLFRAADLDSQFACMLKQAANEIPSKALPLVKEQATNSCINALYAYRKFCATVTSSGQLILPEALKLFPLYTLALTKSVGLRTDGRIDDRSFWINYVSSLSTPLAIPLVYPRMISVHDLDVKDTEGSVLPPPIPLSSEHISNEGVYFLENGEDGLLFVGESVDSDILQKLFAVSSAAEIPNQFVLQQYDNQLSKKFNDAVNEIRRQRCSYLRIKLCKKGEPSGMLFLSYMVEDRTASGPSYVEFLVQVHRQIQLKMN", "length": 1080 }, "evidence": [ { "id": "A0A3Q1LU21", "url": "https://omabrowser.org/oma/group/A0A3Q1LU21/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "COPII-coated vesicle cargo loading", "id": "GO:0090110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090110", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21" } ], "pmid": "" }, { "name": "endoplasmic reticulum exit site", "id": "GO:0070971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070971", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21" } ], "pmid": "" }, { "name": "COPII vesicle coat", "id": "GO:0030127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030127", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21" } ], "pmid": "" }, { "name": "SNARE binding", "id": "GO:0000149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000149", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 368, "end_pos": 370, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" }, { "start_pos": 590, "end_pos": 592, "annotation": "n_glycosylation_sequon" }, { "start_pos": 774, "end_pos": 776, "annotation": "n_glycosylation_sequon" }, { "start_pos": 961, "end_pos": 963, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LU21-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1094, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LU21-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LU21" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LU21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21" }, { "id": "PF00626", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00626" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Gelsolin-like", "eco_id": "ECO_0000259", "start_pos": 961, "end_pos": 1034, "start_aa": "Asn", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LU21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU21" }, { "id": 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[ "Protein" ] }, { "id": "A0A3Q1LV98", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV98-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M057", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M057", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M057-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M057-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M304", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M304", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M304-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M304-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE25", "url": "https://www.uniprot.org/uniprotkb/E1BE25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BE25-1", "url": "https://www.uniprot.org/uniprotkb/E1BE25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N169", "url": "https://www.uniprot.org/uniprotkb/F1N169", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N169-1", "url": "https://www.uniprot.org/uniprotkb/F1N169-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMNNSGYSEAPGFGLGDEVDDMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVENAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGIGEVLVYIEDPEGHTEEAKVVPNNDKNRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPRGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGIQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIVSWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKVKVQGLNSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAETQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGAHLVEVLYDDVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLATEEPVVPAEPMESMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNVP", "length": 2693, "header": "tr|A0A3Q1LU35-1|A0A3Q1LU35_BOVIN Isoform 1 of Filamin C OS=Bos taurus OX=9913 GN=FLNC PE=1 SV=3 CANONICAL=A0A3Q1LU35-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LU35-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35/entry", "sequence": { "sequence": "MMNNSGYSEAPGFGLGDEVDDMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVENAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGIGEVLVYIEDPEGHTEEAKVVPNNDKNRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPRGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGIQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIVSWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKVKVQGLNSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAETQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGAHLVEVLYDDVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLATEEPVVPAEPMESMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNVP", "length": 2693, "header": "tr|A0A3Q1LU35-1|A0A3Q1LU35_BOVIN Isoform 1 of Filamin C OS=Bos taurus OX=9913 GN=FLNC PE=1 SV=3 CANONICAL=A0A3Q1LU35-1" }, "locus": { "chromosome": "4", "start_pos": 92825012, "end_pos": 92797981, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069339.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069339.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058706.3", "url": "https://www.ensembl.org/id/ENSBTAP00000058706.3" } ] } }, { "isoform_ac": "A0A3Q1LV98-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV98/entry", "sequence": { "sequence": "MMNNSGYSEAPGFGLGDEVDDMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVENAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGIGEVLVYIEDPEGHTEEAKVVPNNDKNRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPRGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGIQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIVSWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKVKVQGLNSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAETQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGAHLVEVLYDDVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLACEAMPRVEEPPDVPQLHRPSAYPTHWATEEPVVPAEPMESMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNVP", "length": 2720, "header": "tr|A0A3Q1LV98-1|A0A3Q1LV98_BOVIN Computationally mapped isoform of Filamin C OS=Bos taurus OX=9913 GN=FLNC PE=1 SV=1 CANONICAL=A0A3Q1LU35-1" }, "locus": { "chromosome": "4", "start_pos": 92825012, "end_pos": 92797981, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080811.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080811.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061306.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061306.1" } ] } }, { "isoform_ac": "A0A3Q1M057-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M057/entry", "sequence": { "sequence": "MSSSHSRAGQSAAGAVLGIGADTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVNNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGMGEVEVVIQDPAGQKGTVEPQLEARGDSTYRCSYQPSVEGVHMVHVTFAGVPIPRSPYTVTVGQACNPGACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMIPGTYTVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVAVNKSAEFTVDAKHGGKAPLKVQVQDNEGCPVEATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRTGVELSKPTHFTVNTKAAGKGKLDVQFSGPAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGDAIPKSPFSVGVSPSLDLSKIKVSGLGEKVDVGKDQEFTVKSKGAGGQGKVLSKIVGPSGAAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFSLEAVPPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDPSKVKCSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGIQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYVPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGMAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPTAQPSLRPQQLAPPYTYAQGGQQTWAPERPLVGVNGLDVSSLRPFDLVIPFTIKKGEVTGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPAIFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGIYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGITGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIAGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTATIPQHSAPGPGPTDASKVLAKGVGLSKAYMGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP", "length": 2639, "header": "tr|A0A3Q1M057-1|A0A3Q1LU35_BOVIN Computationally mapped isoform of Filamin C OS=Bos taurus OX=9913 GN=FLNC PE=1 SV=2 CANONICAL=A0A3Q1LU35-1" }, "locus": { "chromosome": "X", "start_pos": 37419544, "end_pos": 37397908, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071764.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071764.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061341.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061341.2" } ] } }, { "isoform_ac": "A0A3Q1M304-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M304/entry", "sequence": { "sequence": "MMNNSGYSEAPGFGLGDEVDDMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVENAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGIGEVLVYIEDPEGHTEEAKVVPNNDKNRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEEPLPPPPAHSVPIVHQAKKVVPPCNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPRGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGIQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIVSWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKVKVQGLNSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAETQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGAHLVEVLYDDVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLATEEPVVPAEPMESMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGDPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGRQRAERGSGGGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNVP", "length": 2726, "header": "tr|A0A3Q1M304-1|A0A3Q1M304_BOVIN Computationally mapped isoform of Filamin C OS=Bos taurus OX=9913 GN=FLNC PE=1 SV=3 CANONICAL=A0A3Q1LU35-1" }, "locus": { "chromosome": "4", "start_pos": 92825012, "end_pos": 92797981, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082393.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082393.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064221.3", "url": "https://www.ensembl.org/id/ENSBTAP00000064221.3" } ] } }, { "isoform_ac": "E1BE25-1", "url": "https://www.uniprot.org/uniprotkb/E1BE25/entry", "sequence": { "sequence": "MSSSHSRAGQSAAGAVLGIGADTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVNNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGMGEVEVVIQDPAGQKGTVEPQLEARGDSTYRCSYQPSVEGVHMVHVTFAGVPIPRSPYTVTVGQACNPGACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMIPGTYTVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVAVNKSAEFTVDAKHGGKAPLKVQVQDNEGCPVEATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRTGVELSKPTHFTVNTKAAGKGKLDVQFSGPAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGDAIPKSPFSVGVSPSLDLSKIKVSGLGEKVDVGKDQEFTVKSKGAGGQGKVLSKIVGPSGAAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGIYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGITGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIAGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTATIPQHSAPGPGPTDASKVLAKGVGLSKAYMGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP", "length": 1574, "header": "tr|E1BE25-1|A0A3Q1LU35_BOVIN Computationally mapped isoform of Filamin C OS=Bos taurus OX=9913 GN=FLNC PE=1 SV=3 CANONICAL=A0A3Q1LU35-1" }, "locus": { "chromosome": "X", "start_pos": 37419544, "end_pos": 37397908, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008207.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008207.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008207.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008207.7" } ] } }, { "isoform_ac": "F1N169-1", "url": "https://www.uniprot.org/uniprotkb/F1N169/entry", "sequence": { "sequence": "MSSSHSRAGQSAAGAVLGIGADTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVNNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGMGEVEVVIQDPAGQKGTVEPQLEARGDSTYRCSYQPSVEGVHMVHVTFAGVPIPRSPYTVTVGQACNPGACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMIPGTYTVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVAVNKSAEFTVDAKHGGKAPLKVQVQDNEGCPVEATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRTGVELSKPTHFTVNTKAAGKGKLDVQFSGPAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGINVTYGGDAIPKSPFSVGVSPSLDLSKIKVSGLGEKVDVGKDQEFTVKSKGAGGQGKVLSKIVGPSGAAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFSLEAVPPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDPSKVKCSGPGLERATAGEAGQFHVDCSSAGSAELTIEIRSEAGLPAEVHIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGIQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDCGDGTYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYVPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGMAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPTAQPSLRPQQLAPPYTYAQGGQQTWAPERPLVGVNGLDVSSLRPFDLVIPFTIKKGEVTGEVRMPSGKVAQPAITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPAIFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKSHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGIYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGITGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIAGSPFKARVTGHRLVSNHSLHETSSVFVDSLTKTATIPQHSAPGPGPTDASKVLAKGVGLSKAYMGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVLVP", "length": 2647, "header": "tr|F1N169-1|F1N169_BOVIN Computationally mapped isoform of Filamin A OS=Bos taurus OX=9913 GN=FLNA PE=1 SV=3 CANONICAL=A0A3Q1LU35-1" }, "locus": { "chromosome": "X", "start_pos": 37419544, "end_pos": 37397908, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030194.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030194.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030179.5", "url": "https://www.ensembl.org/id/ENSBTAP00000030179.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:281165", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281165", "resource": "KEGG Pathway" }, { "id": "bta:528415", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528415", "resource": "KEGG Pathway" }, { "id": "R-BTA-114608", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "resource": "Reactome", "description": "Platelet degranulation" }, { "id": "R-BTA-446353", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446353", "resource": "Reactome", "description": "Cell-extracellular matrix interactions" }, { "id": "R-BTA-5627123", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5627123", "resource": "Reactome", "description": "RHO GTPases activate PAKs" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZV49-1", "protein_name": "Filamin A", "gene_name": "Flna", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSSHSRSGQSAAGASPAGGIDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVNNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGIGEVEVVIQDPTGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPTACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPTIPGTYTVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGIVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVAINKPAEFTVDAKHAGKAPLRVQVQDNEGHSVETTVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPCGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLNRTGVELGKPTHFTVNAKTAGKGKLDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVSVTYGGDHIPKSPFSVGVSPSLDLSKIKVSGLVDKVDVGKDQEFTVKSKGAGGQGKVASKIVSPSGAAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFPVEAVAPTKPSKVKAFGPGLQGGNAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTDTYVQDCGDGTYKVEYTPYEEGVHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGSYSISVLYGEEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPTVQTPLRPQQLPSQYTYPQGSQQTWIPERPMVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPSITDNKDGTVTVRYSPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHITAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNDQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFGIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKVATVPQHATSGPGPADVSKVVAKGLGLSKAYVGQKSNFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHMGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRIMVP", "length": 2647 }, "evidence": [ { "id": "A0A3Q1LU35", "url": "https://omabrowser.org/oma/group/A0A3Q1LU35/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8M9PHR9-1", "protein_name": "Filamin-C isoform X1", "gene_name": "flncb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMSNNTYYDQQLPPQYYQGTDNGEDGDEEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCLNRKILDLQKDLTDGLKLIGLLEVLSQKKMYRKYHARPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKLTPKQRLLGWIQNKVPQLHINNFHRDWRDGKALGALVDNCAPGLCPDWETWDPSQPVENAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKTLHPKRAKAYGPGIEPRGNVVLKPAEFVVETVEAGLGEVLVYIEDPEGHTEEARVIPNNDRNRSYSVVYVPKVEGLHKVKVLFAGQDIDRSPFLVNVSKALGDPNKVQARGPGLEPVGNVANKPTYFDIYTAGAGAGDVGVIIVDSQGRRDTVEIILENKGDSVFRCTYGPILEGPHTIYVTFAGQQIPRSPFTVHISEAPPHGRQIGSPVHIIPQSLRTPPSEKAKKVPPPTPPKPRRPTSNPNACRAIGRGLQPKGVRVKEVADFKVYTKGAGSGELRVHVKGPTGGDEPVKVEDLGDGVYECDYYPIFCGKYIITVTWGGHAIPRSPFEVIISEDAGPQKVRAWGPGLETGMVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVLYWPTEPGDYAVHVICDDEDIKDSPFMAHILPAASDVFPEKVKCYGPGLEPTGCIVNKPAEFTIDARGAGRGQLQIYAQDSEGFPINIQITDNGDSTYFCVYIPIKPIKHTIIITWGEVNVPNSPFRVTIGEGSHPENVKVHGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFADQEIPISPFRIKVDPSHDANKVKAEGPGLNKTGVEVGKPTHFTIYTKGAGKATPEVHFTASGRGDAVSDFEIIDNHDYSFTVRYTALQQGNMTISVCHGGDPIPKSPFTISVAPPLDLNKVKVHGLNNKVDVGKDEEFTVNTRGAGGQGKVDVKITSPSRRPIPCKVESGASNEVHTVKYIPPEEGPYKVDISYDGNPVPGSPFTVEGVMPPDPSKVRAYGPGLKGGIVGKPAPFAIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCSVSYLPTEPGEYSINILFADAHIPGSPFKAMVQSVFDPSKVTASGPGLERGKVNEAGSFTVDCSKAGEAELTIEIISDSGAQAEVHVQNNSDGTYSITYIPPFHGMYTITIKYGGHAVPKFPARVQVDPALDTSGIKVYGPGVEPRGVLREVTTHFIVDTRVHNKMGGNHIKVRIVNPSGANTDAYVTDKADGTYRVEYTAYEDGVHLIEVLYDDVPVPKSPFRVAVAEGCDPSRVRAYGPGLEEGLVNKPNRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCSVEYIPFTPGEYDVNITFGGLPIPGSPFRVPVRELVDPSKVKCTGPGLGSGVRAHVPQTFTVDCSKAGLAPLEVLLYGPTGMTEPVNITDNGDGTHTVVYTPAKDGPYTVCVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNASGVPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNRDGTYTVSYVPDMTGRYTITIKYGGDEIPYSPYRIHALPSGDASKCLVTVSIGGHGLGSGLGPTIQIGEETVITVDAKAAGKGKVTCKVSTPDGAELDVDVVENADGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVVASDTIPIIEEPCDKLQLQQPYAPYQGYSPHWATEEPVTAVDIIEPVLRPFNLVIPFTVQKGEITGEVHMPSGKTASPHITDNKDGTVTVKYAPTEKGLHEMDIKYDGNHIPGSPLQFYVDAINSGHVNAYGPGLSHGMVNKSATFTIVTKDAGEGGLSLAVEGPSKAEISCKDNKDGTCTVSYLPTAPGDYNIIVKFDDKHIAGSPFTAKITGDDSMRTSQLNVGTATDVSLKITETDLSSLSATIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVKKNGKHVTNSPFKIMVGQSEIGDASKVKVSGKGLIEGHTFEVAEFIVDTRSAGYGGLGLSIEGPSKVDINCSDVDDGTCKVTYCPTEPGTYIINIKFADQHVPGSPFTVKVLGEGRMKESITRKRQAPSIATVGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRAGETKREVRVEESTQVGGDPFRDVFGGFMGRESLGPFNSPQGRQSEGESGTQEMTAQVTSPSGNTEDAEIIEGEDSTYSVRFVPHEMGPHTVNVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLDRGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEISFEDRKDGSCGVAYIVQEPGDYEVSIKFNDEHIPDSPFIVPIASLSDDARLLTVTSLQEMGLKVNQEASFAVQLNGARGAIDAKVHTPSGAVEECYITELDNDKHAIRFIPRENGVHSIDVRFNGSHIPGSPFKIRVGEPGQAGDPGMVTAFGPGLEGGTTGVPSDFIVNTCNAGSGALSVTIDGPSKVKMDCQECPEGYKVTYTPMAPGSYLISIKYGGPQHIVGSPFKAKVSGARLSGGHSLHETSSVLVETVTKSSSVAGSFSTLPKFSSDASKVVSRGAGLSKAFIGQKNTFTVDCSKAGTNMLMVGVHGPKTPCEEVYVKHMGNRMYNVTYTVKEKGDYILIVKWGEEMVPGSPFHVTVP", "length": 2773 }, "evidence": [ { "id": "A0A3Q1LU35", "url": "https://omabrowser.org/oma/group/A0A3Q1LU35/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZHA0-1", "protein_name": "Filamin-C", "gene_name": "Flnc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMNNSNYSDASGLGLLDEADEMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVQNAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDNTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVIPGKYVVTITWGGYAIPRSPFEVQVSPEAGAQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDRGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDRPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTVIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGHYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLSRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKVKVQGLNSKVAVGEEQAFLVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGSGAEAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIQPVFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPIPKFPTRVHVQPAVDTSGIKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYVPFTPGDYDVNITFGGQPIPGSPFRVPVKDVVDPGKVKCSGPGLGTGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLACDPLPHVEEPAEVLQLHQPYAPLRPGTCPTHWATEEPVVPVEPLESMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSGHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLKITEGDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTQNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGASYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNVP", "length": 2726 }, "evidence": [ { "id": "A0A3Q1LU35", "url": "https://omabrowser.org/oma/group/A0A3Q1LU35/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SMN5-1", "protein_name": "Filamin C", "gene_name": "FLNC", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMNNSGYSEAAGLGLGDEVDDMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVENAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVRDAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGMQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKVKVQGLNSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGADAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDDVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVAVLSPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLACDPMPHVEEPSEVLQLHRPSAYPTHWATEEPVVPVESMESMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHVGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNVP", "length": 2720 }, "evidence": [ { "id": "A0A3Q1LU35", "url": "https://omabrowser.org/oma/group/A0A3Q1LU35/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P21333-1", "protein_name": "Filamin-A", "gene_name": "FLNA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAVSPSLDLSKIKVSGLGEKVDVGKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHVPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVVVP", "length": 2647 }, "evidence": [ { "id": "A0A3Q1LU35", "url": "https://omabrowser.org/oma/group/A0A3Q1LU35/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q14315-1", "protein_name": "Filamin-C", "gene_name": "FLNC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMNNSGYSDAGLGLGDETDEMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVENAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPAMEGPHTVHVAFAGAPITRSPFPVHVSEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGVQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKIKVQGLNSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFDPSKVRASGPGLERGKVGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGQETVITVDAKAAGEGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLACDPLPHEEEPSEVPQLRQPYAPPRPGARPTHWATEEPVVPVEPMESMLRPFNLVIPFAVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVKVP", "length": 2725 }, "evidence": [ { "id": "A0A3Q1LU35", "url": "https://omabrowser.org/oma/group/A0A3Q1LU35/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BTM8-1", "protein_name": "Filamin-A", "gene_name": "Flna", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSSHSRCGQSAAVASPGGSIDSRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVNNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGMGEVEVVIQDPTGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPAACRAIGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPTIPGTYTVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGIVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHAGKAPLRVQVQDNEGCSVEATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPCGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLNRTGVELGKPTHFTVNAKTAGKGKLDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYIPVQQGPVGVNVTYGGDHIPKSPFSVGVSPSLDLSKIKVSGLGDKVDVGKDQEFTVKSKGAGGQGKVASKIVSPSGAAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGNAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVAPCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTDTYVQDCGDGTYKVEYTPYEEGVHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGSYSISVLYGEEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVPGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPTVQTPLRSQQLAPQYNYPQGSQQTWIPERPMVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPSITDNKDGTVTVRYSPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHITAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNDQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANIGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEVGVPAEFGIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGIYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKVATVPQHATSGPGPADVSKVVAKGLGLSKAYVGQKSNFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHMGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRIMVP", "length": 2647 }, "evidence": [ { "id": "A0A3Q1LU35", "url": "https://omabrowser.org/oma/group/A0A3Q1LU35/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8VHX6-1", "protein_name": "Filamin-C", "gene_name": "Flnc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMNNSNYSDASGLGLVDEADEMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVQNAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDNTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVHVAEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGAQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDRPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIVSWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPVEADIDFDIIKNDNDTFTVKYTPPGAGHYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLSRTGVEVGKPTHFTVLTKGAGKAKLDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKVKVQGLNSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIQPVFDPSKVRASGPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIQNNADGTYHITYSPAFPGTYTITIKYGGHPIPKFPTRVHVQPAVDTSGIKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGQPIPGSPFRVPVKDVVDPGKVKCSGPGLGTGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPSHDASKVRASGPGLNASGIPASLPVEFTIDARDAGQGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLACDPLPHVEEPAEMLQMRQPYAPLRPGTCPTHWATEEPVVPVEPLESMLRPFNLVIPFTVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLKITEGDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTQNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGASYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVNVP", "length": 2726 }, "evidence": [ { "id": "A0A3Q1LU35", "url": "https://omabrowser.org/oma/group/A0A3Q1LU35/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 11, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "ankyrin binding", "id": "GO:0030506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030506", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "G protein-coupled receptor binding", "id": "GO:0001664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001664", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "potassium channel regulator activity", "id": "GO:0015459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015459", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "Fc-gamma receptor I complex binding", "id": "GO:0034988", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034988", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "protein sequestering activity", "id": "GO:0140311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140311", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 20, "go_terms": [ { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "sarcomere organization", "id": "GO:0045214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045214", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "positive regulation of protein import into nucleus", "id": "GO:0042307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042307", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "semaphorin-plexin signaling pathway", "id": "GO:0071526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071526", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "establishment of protein localization", "id": "GO:0045184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045184", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "positive regulation of substrate adhesion-dependent cell spreading", "id": "GO:1900026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900026", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "adenylate cyclase-inhibiting dopamine receptor signaling pathway", "id": "GO:0007195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007195", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "actin crosslink formation", "id": "GO:0051764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051764", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "negative regulation of protein catabolic process", "id": "GO:0042177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042177", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "positive regulation of potassium ion transmembrane transport", "id": "GO:1901381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901381", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "receptor clustering", "id": "GO:0043113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043113", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "protein localization to cell surface", "id": "GO:0034394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034394", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase I", "id": "GO:0016479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016479", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "positive regulation of integrin-mediated signaling pathway", "id": "GO:2001046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001046", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "wound healing, spreading of cells", "id": "GO:0044319", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044319", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" }, { "name": "Myb complex", "id": "GO:0031523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031523", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU35" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1421, "end_pos": 1423, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1551, "end_pos": 1553, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1781, "end_pos": 1783, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2661, "end_pos": 2663, "annotation": "n_glycosylation_sequon" }, { "start_pos": 334, "end_pos": 336, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": 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"sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 1421, "end_pos": 1423 }, { "start_pos": 1551, "end_pos": 1553 }, { "start_pos": 1781, "end_pos": 1783 }, { "start_pos": 2661, "end_pos": 2663 }, { "start_pos": 334, "end_pos": 336 }, { "start_pos": 3, "end_pos": 5 }, { "start_pos": 827, "end_pos": 829 }, { "start_pos": 879, "end_pos": 881 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "exact_sites", "count": 4 }, { "field": 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], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LU43-1", "uniprot_ac": "A0A3Q1LU43", "uniprot_id": "A0A3Q1LU43_BOVIN", "mass": { "chemical_mass": 93284.0, "monoisotopic_mass": 93284.0 }, "refseq": { "ac": "XP_059741188", "name": "granulocyte colony-stimulating factor receptor isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741188" }, "gene_names": [ { "name": "CSF3R", "type": "recommended", "evidence": [ { "id": "A0A3Q1LU43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU43" } ] }, { "name": "CSF3R", "type": "synonym", "evidence": [ { "id": "XP_059741188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741188" } ] } ], "protein_names": [ { "name": "Granulocyte colony-stimulating factor receptor", "type": "recommended", "evidence": [ { "id": "A0A3Q1LU43", "database": "UniProtKB", "url": 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"crossref": [ { "id": "A0A3Q1LU43", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LU43", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013334", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013334", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "132344945", "url": "https://www.ncbi.nlm.nih.gov/gene/132344945", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003529", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003529", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052672", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052672", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SYCSIPR", "url": "https://omabrowser.org/oma/group/SYCSIPR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR48423", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48423", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48423:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48423:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06328", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06328", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-449836", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-449836", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9674555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9674555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9705462", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9705462", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059741188", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741188", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LU43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LU43-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU43-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9W2", "url": "https://www.uniprot.org/uniprotkb/E1B9W2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9W2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9W2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGLGAWSLVGAALIILLLPRSLEQCGHILLSAPIVRLGDQVTASCIINRNCSHLGTDWRVVWKLEPELHPRERRQHLPNGTLQSTITLPHLNHSRVLLSCCLHWGNSLQILDQAELQAGYPPTAPYNLSCIMNLTTNSLICQWEPGPNTHLSTSFTLKSFKSQDKCQTQKDSIPDCVPEVGQSHCSIPRKHLQLYQNMSIWVQARNALGTSASPKLCLAPMDVVKLEPPTLWALEPSPAVAPPQPGCLRLRWETWRPSLYIEQKCELRHQPRLGEAGWDLVSALPARTSQYELCGLLPSTAYTLQMRCTRWRLPGHWSEWSPSLELTTAQRAPIVRLDTWWRQRQLDPETVTVQLFWKPIALEEDSGQIQGYLVSWRPSDQAGAEPTLCDTTELNCTFQLPSEAREVVLKAYNTAGTSHPTPVVFLESRGPPLGRLHTTARDPHSLWVGWEPPSPQPQGYVIEWGLSPPSPNGSPMTWRMEHNGSIAGTLLQENIRPFQLYEITVTPLYQDTKGPSQHIYAYSQEMAPSHGPELHLRHIGKTWAQLEWVPEAPELGKSPLTHYTIFWTNTQDQSFSTVLNASTHSFVLRGLEPSSLYHVQLMAASQVWAANSTSLTLMTLTLEESELHILLGLFGLLVLLICLCGAAQFCCRPSRKYSLWPSVPDPARSSLGSWVPTITAEDILQLPSLRDPGMPPITKITVLEEEEKKPGPWESNASSGPGSLSTLVQAYVLQGDPRVPSAQPQPQPGNSDQVLYVQVLGSPTGPGPGHYLRCDSTQPLLEGLSPSPKSYENLWFQTSSPGTPEPLVPHPEDDSIFEPLLDFPLLQGLRVSGAEGLGGF", "length": 841, "header": "tr|A0A3Q1LU43-1|A0A3Q1LU43_BOVIN Isoform 1 of Granulocyte colony-stimulating factor receptor OS=Bos taurus OX=9913 GN=CSF3R PE=3 SV=2 CANONICAL=A0A3Q1LU43-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LU43-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU43/entry", "sequence": { "sequence": "MVGLGAWSLVGAALIILLLPRSLEQCGHILLSAPIVRLGDQVTASCIINRNCSHLGTDWRVVWKLEPELHPRERRQHLPNGTLQSTITLPHLNHSRVLLSCCLHWGNSLQILDQAELQAGYPPTAPYNLSCIMNLTTNSLICQWEPGPNTHLSTSFTLKSFKSQDKCQTQKDSIPDCVPEVGQSHCSIPRKHLQLYQNMSIWVQARNALGTSASPKLCLAPMDVVKLEPPTLWALEPSPAVAPPQPGCLRLRWETWRPSLYIEQKCELRHQPRLGEAGWDLVSALPARTSQYELCGLLPSTAYTLQMRCTRWRLPGHWSEWSPSLELTTAQRAPIVRLDTWWRQRQLDPETVTVQLFWKPIALEEDSGQIQGYLVSWRPSDQAGAEPTLCDTTELNCTFQLPSEAREVVLKAYNTAGTSHPTPVVFLESRGPPLGRLHTTARDPHSLWVGWEPPSPQPQGYVIEWGLSPPSPNGSPMTWRMEHNGSIAGTLLQENIRPFQLYEITVTPLYQDTKGPSQHIYAYSQEMAPSHGPELHLRHIGKTWAQLEWVPEAPELGKSPLTHYTIFWTNTQDQSFSTVLNASTHSFVLRGLEPSSLYHVQLMAASQVWAANSTSLTLMTLTLEESELHILLGLFGLLVLLICLCGAAQFCCRPSRKYSLWPSVPDPARSSLGSWVPTITAEDILQLPSLRDPGMPPITKITVLEEEEKKPGPWESNASSGPGSLSTLVQAYVLQGDPRVPSAQPQPQPGNSDQVLYVQVLGSPTGPGPGHYLRCDSTQPLLEGLSPSPKSYENLWFQTSSPGTPEPLVPHPEDDSIFEPLLDFPLLQGLRVSGAEGLGGF", "length": 841, "header": "tr|A0A3Q1LU43-1|A0A3Q1LU43_BOVIN Isoform 1 of Granulocyte colony-stimulating factor receptor OS=Bos taurus OX=9913 GN=CSF3R PE=3 SV=2 CANONICAL=A0A3Q1LU43-1" }, "locus": { "chromosome": "3", "start_pos": 109428922, "end_pos": 109418299, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079569.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079569.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058717.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058717.2" } ] } }, { "isoform_ac": "E1B9W2-1", "url": "https://www.uniprot.org/uniprotkb/E1B9W2/entry", "sequence": { "sequence": "MVGLGAWSLVGAALIILLLPRSLEQCGHILLSAPIVRLGDQVTASCIINRNCSHLGTDWRVVWKLEPELHPRERRQHLPNGTLQSTITLPHLNHSRVLLSCCLHWGNSLQILDQAELQAGYPPTAPYNLSCIMNLTTNSLICQWEPGPNTHLSTSFTLKSFKSQDKCQTQKDSIPDCVPEVGQSHCSIPRKHLQLYQNMSIWVQARNALGTSASPKLCLAPMDVVKLEPPTLWALEPSPAVAPPQPGCLRLRWETWRPSLYIEQKCELRHQPRLGEAGWDLVSALPARTSQYELCGLLPSTAYTLQMRCTRWRLPGHWSEWSPSLELTTAQRAPIVRLDTWWRQRQLDPETVTVQLFWKPIALEEDSGQIQGYLVSWRPSDQAGAEPTLCDTTELNCTFQLPSEAREVVLKAYNTAGTSHPTPVVFLESRGPPLGRLHTTARDPHSLWVGWEPPSPQPQGYVIEWGLSPPSPNGSPMTWRMEHNGSIAGTLLQAPSHGPELHLRHIGKTWAQLEWVPEAPELGKSPLTHYTIFWTNTQDQSFSTVLNASTHSFVLRGLEPSSLYHVQLMAASQVWAANSTSLTLMTLTLEESELHILLGLFGLLVLLICLCGAAQFCCRPSRKYSLWPSVPDPARSSLGSWVPTITAEDILQLPSLRDPGMPPITKITVLEEEEKKPGPWESNASSGPGSLSTLVQAYVLQGDPRVPSAQPQPQPGNSDQVLYVQVLGSPTGPGPGHYLRCDSTQPLLEGLSPSPKSYENLWFQTSSPGTPEPLVPHPEDDSIFEPLLDFPLLQGLRVSGAEGLGGF", "length": 807, "header": "tr|E1B9W2-1|E1B9W2_BOVIN Computationally mapped isoform of Granulocyte colony-stimulating factor receptor OS=Bos taurus OX=9913 GN=CSF3R PE=3 SV=5 CANONICAL=A0A3Q1LU43-1" }, "locus": { "chromosome": "3", "start_pos": 109428922, "end_pos": 109418299, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017732.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017732.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017732.7", "url": "https://www.ensembl.org/id/ENSBTAP00000017732.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-449836", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-449836", "resource": "Reactome", "description": "Other interleukin signaling" }, { "id": "R-BTA-9674555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9674555", "resource": "Reactome", "description": "Signaling by CSF3 (G-CSF)" }, { "id": "R-BTA-9705462", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9705462", "resource": "Reactome", "description": "Inactivation of CSF3 (G-CSF) signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QXL6-1", "protein_name": "Granulocyte colony-stimulating factor receptor", "gene_name": "CSF3R", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVAGLGAWSLAGAVLIILLLPRSLEECGYISLPAPIIRLGDPITVSCIINQNCTSLGPESQIRWKLDTELQPGGRQQHLPNGTLQSTITFPHFNYSRALLSCCLHWGNGLQILDQAELQAGYPPPPPYNLSCLLNLTTNSLKCQWEPGPDTHLSTHFTLKSFKSRGNFQTQEDSIPDCVPEDGQNHCSIPRKHLQLYQNMSIWVQAKNALGTSTSPKLCLVPMDMVKLEPPTLWALEPSPEVAPPQPGCLRLRWETWKPSLHIEQKCELRHQPQRGESSWDLVGALPSRSLQYELCGLLPSTAYTLQMRCTRWPLPGRWSDWSPRLELTTAQQPPIVRLDTWWRQRQLDPRTVDVQLFWKPMPLQEDSGQIQGYLVSWRPSDQAEADPILCNTTELNCTFQLPSEAREVVLVAYNAAGTSRPTPVVFLESRGPPLRRLRTTARDPHSLWVGWEPPSPRPRGYVIEWGLGTPSPGGNPMTWRMEHNGSIAGTLLQENIKPFQLYKITVTALYQDAKGPSQHIYAYSQEMAPSHGPELHLRHIGKTWAQLEWVPEAPELGKSPLTHYTIFWTNAQDQSFSTVLNASSHGFVLRGLEPASLYHVHLMAVSQAWTTNSTSLTLMTLALEESELHILLGLFGLLVLFFCLCGAAQLCCRPRKNPLWPSVPDPAHSSLGSWVPTITAEDTFQLPSLRDPGMPPITKITVLEEEEKKPGPWESKSGPWESNDSSGTCSHPTLVQAYVLQGDPRVPATQAQPQSSTSDQVLYVQVLGSPTSPGPGHYLRCDSTQPLLGGLTPSPKSYENLWFQTSPLGTPEPLVPNPEDDCIFEPLLDFPLLQGLRVSGAEGLGGF", "length": 848 }, "evidence": [ { "id": "A0A3Q1LU43", "url": "https://omabrowser.org/oma/group/A0A3Q1LU43/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6B3M3-1", "protein_name": "Colony stimulating factor 3 receptor", "gene_name": "Csf3r", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVGLGACNLTGVTLIVLLLPRSLEGCGQIRISPPIVHLGDPVLASCTISPNCSKLDRQPKILWRLQDEPNQPGDRQHHLPDGSQESIITLPHLNYTQAFLFCLVPWNNSFQVLDQAELRAGYPPASPSNLSCLMYLTTNSLVCQWEPGPETHLPTSFILKSFRSRTGCQYQGGTILDCMPKKRHSNCSIPRKHLLLYQNMVIWVQAENMLGSSESPKLCIDPMDVGRESLTTPPPAVKLEPPMLQALDIGHDIVSRQPGCLWLSWKPWKPSEFMEQECELRYQPQLEGANWTLVRPRKTSRWRWGMERGQAGFSVTPPTHQVSHLPSSTDRFELCSLHQAPVYTLQLRCIRSSLPGLWSSWSPGLQLRPTIKAPTIRLDTWWQKKHLDPETVRMQLFWKPTPLQKDSGQIQGYLLSWSCPDGQGRIMHLCNTTELSCTFHLPSEAQNVTLVAYNSAGTSSPTLVVFLEHEGPAVTSLHAMAQDLGSIWVDWEAPSLLPQGYLIEWGPDSHKYSNNSWRIEPNGNTTGILLEDNIHPFQLYRITVAPLYPGTVGPPVNVYTYSGEKALPHAPELYLKHVGRTWAQLEWVPETPWLGMIPLTNYTIFWTDARDHSFSVTLNISFHDFVLDHLKPASLYHVYLMATSRAGSTNSTGLTLMTMALDSSDVNIFLGILCFVLLSITCATAWFCCKQSRKTFFWPNVPDPAHSSLSAWVPTIMTEETFQLPSFWGSSVPSITKITELEEDKKPTHWDPSESSGTGSLPAVVQAYVLQGDPREISNQFQPPSSTNDQVLYGQVLGSPTSPEVVGYLRCDSTQPLLGGPTPSPKSYENIWFHSRPQETFIPQPPSQEDDCVFGPPFDFPLFQGLQVHGVEEQGGF", "length": 877 }, "evidence": [ { "id": "A0A3Q1LU43", "url": "https://omabrowser.org/oma/group/A0A3Q1LU43/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0YPI5-1", "protein_name": "Colony stimulating factor 3 receptor", "gene_name": "CSF3R", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARRGAGSPLLLQLSLLLLLSPSGTQQSGAELDCASVAVGAPVVPMGSAVTASCTIRRERCRGLEDGQPLISWLLDSEPMAGRQRRGVGGTEVSELRVPQLNRPQAKLWCCVEWNGTKQRVGVAEIRAGYPPGKPSNLSCLLDLGDYGLTCRWQQGADGHLPTNIMLKCATSRSPAVTGCTPQNGHSQCTVPRRLLQLYRPMELWVTATNALGTAESERLRIDPMDVAKLDPPTLQSIRSMPPQTDCVTLTWTMTPRNAHMELRCELRYRAPEDPSWGVLTGIAGHAGTVQHCKFLFGTLYHFQMRCRRDLARGYWSEWSVSRNYTTHEKAPEGKLDAWWSTRTAAGRMEVQLRWKAPRRQEANGRVLGYRVALGSRRRGREPQTVCNTNDTHCDFTVPVRTGRVYLSAYNAAGESSATEVILLERKGQPLAGLRAVPAGDRSLWVHWEAAPVPVVAYVLEWQPVSSEPRHCSACWQLERNGTTTTTLIRDSIEPFQQYNISVYPLYKDAVGTPAYIAAYSKQKAPSHAPKLHLKSIGKSQAKLSWEPVAVELQNGFITHYTVFWANSTAEVSSAVVNSSLSSFTIQGLKPSTLYKVHIMASTAGGSINGTTLTLVTTMLDDTEIQFLFLTLGLVFVLLIILLICFQKNGRVKQQFWPSVPDPANSSLGTWVPAEQEPLQAPGVKEPGLATISTVTVLDKAAGKQTPTWGKEPPAEPLAPPQPYMQQHRPGTLQANSGLAAEPVQYVQVVGGSSQGPQHVAPCLYLRSSSTQPLLSDPSPEPYENLWFRGAAPSCARGSLEEPLLDFPLLRGLRVSGAEELHDFQPC", "length": 827 }, "evidence": [ { "id": "A0A3Q1LU43", "url": "https://omabrowser.org/oma/group/A0A3Q1LU43/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P40223-1", "protein_name": "Granulocyte colony-stimulating factor receptor", "gene_name": "Csf3r", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVGLGACTLTGVTLIFLLLPRSLESCGHIEISPPVVRLGDPVLASCTISPNCSKLDQQAKILWRLQDEPIQPGDRQHHLPDGTQESLITLPHLNYTQAFLFCLVPWEDSVQLLDQAELHAGYPPASPSNLSCLMHLTTNSLVCQWEPGPETHLPTSFILKSFRSRADCQYQGDTIPDCVAKKRQNNCSIPRKNLLLYQYMAIWVQAENMLGSSESPKLCLDPMDVVKLEPPMLQALDIGPDVVSHQPGCLWLSWKPWKPSEYMEQECELRYQPQLKGANWTLVFHLPSSKDQFELCGLHQAPVYTLQMRCIRSSLPGFWSPWSPGLQLRPTMKAPTIRLDTWCQKKQLDPGTVSVQLFWKPTPLQEDSGQIQGYLLSWSSPDHQGQDIHLCNTTQLSCIFLLPSEAQNVTLVAYNKAGTSSPTTVVFLENEGPAVTGLHAMAQDLNTIWVDWEAPSLLPQGYLIEWEMSSPSYNNSYKSWMIEPNGNITGILLKDNINPFQLYRITVAPLYPGIVGPPVNVYTFAGERAPPHAPALHLKHVGTTWAQLEWVPEAPRLGMIPLTHYTIFWADAGDHSFSVTLNISLHDFVLKHLEPASLYHVYLMATSRAGSTNSTGLTLRTLDPSDLNIFLGILCLVLLSTTCVVTWLCCKRRGKTSFWSDVPDPAHSSLSSWLPTIMTEETFQLPSFWDSSVPSITKITELEEDKKPTHWDSESSGNGSLPALVQAYVLQGDPREISNQSQPPSRTGDQVLYGQVLESPTSPGVMQYIRSDSTQPLLGGPTPSPKSYENIWFHSRPQETFVPQPPNQEDDCVFGPPFDFPLFQGLQVHGVEEQGGF", "length": 837 }, "evidence": [ { "id": "A0A3Q1LU43", "url": "https://omabrowser.org/oma/group/A0A3Q1LU43/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99062-1", "protein_name": "Granulocyte colony-stimulating factor receptor", "gene_name": "CSF3R", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWPSVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGLPTLVQTYVLQGDPRAVSTQPQSQSGTSDQVLYGQLLGSPTSPGPGHYLRCDSTQPLLAGLTPSPKSYENLWFQASPLGTLVTPAPSQEDDCVFGPLLNFPLLQGIRVHGMEALGSF", "length": 836 }, "evidence": [ { "id": "A0A3Q1LU43", "url": "https://omabrowser.org/oma/group/A0A3Q1LU43/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU43" } ], "pmid": "" }, { "name": "endocytic vesicle membrane", "id": "GO:0030666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030666", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU43" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU43" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU43" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU43" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU43" } ], "pmid": "" }, { "name": "cytokine-mediated signaling pathway", "id": "GO:0019221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU43" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "cytokine receptor activity", "id": "GO:0004896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004896", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU43" } ], "pmid": "" }, { "name": "granulocyte colony-stimulating factor binding", "id": "GO:0051916", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051916", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU43" } ], "pmid": "" }, { "name": "cytokine binding", "id": "GO:0019955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019955", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU43" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 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"phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 }, { "start_pos": 134, "end_pos": 136 }, { "start_pos": 198, "end_pos": 200 }, { "start_pos": 396, "end_pos": 398 }, { "start_pos": 473, "end_pos": 475 }, { "start_pos": 484, "end_pos": 486 }, { "start_pos": 51, "end_pos": 53 }, { "start_pos": 581, "end_pos": 583 }, { "start_pos": 612, "end_pos": 614 }, { "start_pos": 717, "end_pos": 719 }, { "start_pos": 80, "end_pos": 82 }, { "start_pos": 93, "end_pos": 95 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ 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"count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LU66-1", "uniprot_ac": "A0A3Q1LU66", "uniprot_id": "A0A3Q1LU66_BOVIN", "mass": { "chemical_mass": 69040.0, "monoisotopic_mass": 69040.0 }, "refseq": {}, "gene_names": [ { "name": "LMF1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LU66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU66" } ] } ], "protein_names": [ { "name": "Lipase maturation factor", "type": "recommended", "evidence": [ { "id": "A0A3Q1LU66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU66/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in the maturation of specific proteins in the endoplasmic reticulum.", "evidence": [ { "database": "UniProtKB", "id": "A0A452DHY3", "url": "https://www.uniprot.org/uniprotkb/A0A452DHY3#function" }, { "database": "UniProtKB", "id": "RU361229", "url": "https://www.uniprot.org/uniprotkb/RU361229#function" }, { "database": "UniProtKB", "id": "A0A3Q1LU66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU66#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU66" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LMF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU66", "locus": { "chromosome": "25", "start_pos": 725402, "end_pos": 777224, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019745", "url": "https://www.ensembl.org/id/ENSBTAG00000019745" } ] } } ], "crossref": [ { "id": "A0A3Q1LU66", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LU66", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019745", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019745", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR009613", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009613", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057434", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057434", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LU66", "url": "https://www.orthodb.org/?gene=A0A3Q1LU66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A452DHY3", "url": "https://www.orthodb.org/?gene=A0A452DHY3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14463", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14463", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14463:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14463:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06762", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06762", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8963889", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8963889", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LU66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LU66-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DHY3", "url": "https://www.uniprot.org/uniprotkb/A0A452DHY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DHY3-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DHY3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRGLAERAATGQELAPGRQAWPQVWAGPRGGAGLAAPRRMRRAGPAMAAPRESLRRRKAGAGDPEPEAPPGQGRDLKGRPARLRAGTFWLTRIVLLRALAFVYFVAFLVAFHQNKQLIGDRGLLPCRAYLQSVQRHFGGRVSWDALSYAPTILWLLDWSHMDANLDALALLGLGISSFILVSGCANMVLMAALWVLYMSLVNVGQIWYSFGWESQLLETGFLGIFLCPLWTLSALPRGTPTSWVVMWGFRWLIFRIMLGAGLIKIRGDRCWRDLTCMDFHYETQPVPNPVAYFLHRSPWWFHRFETLSNHFLELVVPFFIFLGRRMCIVHGALQVLFQVVLIISGNLSFLNWLTIVPSLACFDDATLGGLFPSGPGRLKDQVLKIQEEETRGARAPRTRAGSVARGTVNLALGILVAWLSIPVVLNLLSPRQVMNSSFNPLRIVNTYGAFGSITRERTEVILQGTASANASAPDSAWEDYEFKCKPGDPRRRPCLISPYHHRLDWLMWFAAFQTYEHNEWIIHLAGKLLANDAQALSLLARNPFEGRDPPRWVRGEHYRYKFSRPGGRHAAEGKWWIRRRLGPYFPPLSRQDLRGYFTSRQWPYPEPE", "length": 609, "header": "tr|A0A3Q1LU66-1|A0A3Q1LU66_BOVIN Isoform 1 of Lipase maturation factor OS=Bos taurus OX=9913 GN=LMF1 PE=3 SV=2 CANONICAL=A0A3Q1LU66-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LU66-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU66/entry", "sequence": { "sequence": "MRRGLAERAATGQELAPGRQAWPQVWAGPRGGAGLAAPRRMRRAGPAMAAPRESLRRRKAGAGDPEPEAPPGQGRDLKGRPARLRAGTFWLTRIVLLRALAFVYFVAFLVAFHQNKQLIGDRGLLPCRAYLQSVQRHFGGRVSWDALSYAPTILWLLDWSHMDANLDALALLGLGISSFILVSGCANMVLMAALWVLYMSLVNVGQIWYSFGWESQLLETGFLGIFLCPLWTLSALPRGTPTSWVVMWGFRWLIFRIMLGAGLIKIRGDRCWRDLTCMDFHYETQPVPNPVAYFLHRSPWWFHRFETLSNHFLELVVPFFIFLGRRMCIVHGALQVLFQVVLIISGNLSFLNWLTIVPSLACFDDATLGGLFPSGPGRLKDQVLKIQEEETRGARAPRTRAGSVARGTVNLALGILVAWLSIPVVLNLLSPRQVMNSSFNPLRIVNTYGAFGSITRERTEVILQGTASANASAPDSAWEDYEFKCKPGDPRRRPCLISPYHHRLDWLMWFAAFQTYEHNEWIIHLAGKLLANDAQALSLLARNPFEGRDPPRWVRGEHYRYKFSRPGGRHAAEGKWWIRRRLGPYFPPLSRQDLRGYFTSRQWPYPEPE", "length": 609, "header": "tr|A0A3Q1LU66-1|A0A3Q1LU66_BOVIN Isoform 1 of Lipase maturation factor OS=Bos taurus OX=9913 GN=LMF1 PE=3 SV=2 CANONICAL=A0A3Q1LU66-1" }, "locus": { "chromosome": "25", "start_pos": 777179, "end_pos": 725449, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082383.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082383.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064052.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064052.2" } ] } }, { "isoform_ac": "A0A452DHY3-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DHY3/entry", "sequence": { "sequence": "MRHNRCPTLWPTSCTAPRGGSTASRPSATTSWSWWCPSSSSSDGGCASSTGPCRSCSSSGSAARVDSGRRCGTRTLGREEPELDPERSGQLVALDVTLKGQPCTRLPSSKALGASVQERAEDVSTRTSSHAQFAQLFRKVLRVLQRQPVVYMGRRTTSTSDPHALPRRDPAGPVVSFCCGPSRTSYPHVNQARGSWSTQSHIPDSRPYLPPRPAFSKLHDISHSPRNIAVGTSLQLWAQRAAPTSLSDLSTAGVVLIISGNLSFLNWLTIVPSLACFDDATLGGLFPSGPGRLKDQVLKIQEEETRGARAPRTRGSVARGTVNLALGILVAWLSIPVVLNLLSPRQVMNSSFNPLRIVNTYGAFGSITRERTEVILQGTASANASAPDSAWEDYEFKCKPGDPRRRPCLISPYHHRLDWLMWFAAFQTYEHNEWIIHLAGKLLANDAQALSLLARNPFEGRDPPRWVRGEHYRYKFSRPGGRHAAEGKWWIRRRLGPYFPPLSRQDLRGYFTSRQWPYPEPE", "length": 522, "header": "tr|A0A452DHY3-1|A0A3Q1LU66_BOVIN Computationally mapped isoform of Lipase maturation factor OS=Bos taurus OX=9913 GN=LMF1 PE=3 SV=2 CANONICAL=A0A3Q1LU66-1" }, "locus": { "chromosome": "25", "start_pos": 739748, "end_pos": 725449, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004206.7", "url": "https://www.ensembl.org/id/ENSBTAT00000004206.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004206.7", "url": "https://www.ensembl.org/id/ENSBTAP00000004206.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8963889", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8963889", "resource": "Reactome", "description": "Assembly of active LPL and LIPC lipase complexes" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "triglyceride metabolic process", "id": "GO:0006641", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006641", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU66" } ], "pmid": "" }, { "name": "protein maturation", "id": "GO:0051604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051604", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU66" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU66" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 436, "end_pos": 438, "annotation": "n_glycosylation_sequon" }, { "start_pos": 470, "end_pos": 472, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LU66-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 609, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LU66-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LU66" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LU66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU66" }, { "id": "PF25179", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25179" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Lipase maturation factor 1/2 C-terminal", "eco_id": "ECO_0000259", "start_pos": 444, "end_pos": 587, "start_aa": "Ile", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LU66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU66" }, { "id": "PF06762", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06762" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Lipase maturation factor 1/2 N-terminal", "eco_id": "ECO_0000259", "start_pos": 209, "end_pos": 368, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 347, "end_pos": 349 }, { "start_pos": 436, "end_pos": 438 }, { "start_pos": 470, "end_pos": 472 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LU72-1", "uniprot_ac": "A0A3Q1LU72", "uniprot_id": "A0A3Q1LU72_BOVIN", "mass": { "chemical_mass": 35122.0, "monoisotopic_mass": 35122.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0A3Q1LU72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU72/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU72", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU72#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LU72", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU72" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU72", "locus": {} } ], "crossref": [ { "id": "A0A3Q1LU72", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LU72", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000055261", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000055261", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15236", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15236", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IMRENLC", "url": "https://omabrowser.org/oma/group/IMRENLC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LU72", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LU72-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU72-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPENQSSVSEFLLLGLPIRPEQQGVFFALFLGVYLTTVLGNLLILLLIRLDPRLHTPMYFFLSHLALTDISFSSVTLPKMLMNMQTRCQAITYAGCISQVYCFIFFGCLDSFLLAVMAYDRYVAVCHPLHYTAIMRDELCVILVAGCWLAACAQALLHTLLVDQLTFCAGTVIPHFFCDLAVVLKSSCSDTSLNELLILTEGGLIFTLPLGGILGSYIRMAAIILKVPSFTRIFKAFSNCTSHLSVVSLFYTTAIGVYLCPPSSPSGGKDRVFSVMYTVVTPLLNPFIYSLRNRDIKGALGKILRRNMFNTLSWD", "length": 316, "header": "tr|A0A3Q1LU72-1|A0A3Q1LU72_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0A3Q1LU72-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LU72-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU72/entry", "sequence": { "sequence": "MRPENQSSVSEFLLLGLPIRPEQQGVFFALFLGVYLTTVLGNLLILLLIRLDPRLHTPMYFFLSHLALTDISFSSVTLPKMLMNMQTRCQAITYAGCISQVYCFIFFGCLDSFLLAVMAYDRYVAVCHPLHYTAIMRDELCVILVAGCWLAACAQALLHTLLVDQLTFCAGTVIPHFFCDLAVVLKSSCSDTSLNELLILTEGGLIFTLPLGGILGSYIRMAAIILKVPSFTRIFKAFSNCTSHLSVVSLFYTTAIGVYLCPPSSPSGGKDRVFSVMYTVVTPLLNPFIYSLRNRDIKGALGKILRRNMFNTLSWD", "length": 316, "header": "tr|A0A3Q1LU72-1|A0A3Q1LU72_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0A3Q1LU72-1" }, "locus": { "chromosome": "11", "start_pos": 93727437, "end_pos": 93710855, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069167.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069167.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060666.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060666.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1RV63-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110259694", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": 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"A0A3Q1LUD4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUD4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUD4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUD4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LUD4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 112, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LUD4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LUD4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], 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"database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523504", "url": "https://www.ncbi.nlm.nih.gov/gene/523504", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006553", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050648", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050648", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523504", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523504", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LUD8", "url": "https://www.orthodb.org/?gene=A0A3Q1LUD8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13382", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13382", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13382:SF72", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13382:SF72", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12937", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12937", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25372", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25372", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9708530", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9708530", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024851106", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851106", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUD8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUD8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUD8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LUG9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019237", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019237", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03005", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03005", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615027", "url": "https://www.ncbi.nlm.nih.gov/gene/615027", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005788", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005788", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": 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"database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00085", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00085", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-432720", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432720", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-432722", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193661", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUG9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUG9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NR06", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NR06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NR06-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NR06-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUQ9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPARAGRLLPPRPRALAPAMPPPLLLLLLLLLDAGGGRGGARAQEPGSAAADGPPAAGGGGGQDPHAKHLYTADMFAHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLADKYNSLEDAKVYVAKVDCTADSEVCSAQGVRGYPTLKFFKPGQEAVKYQGPRDFQALEKWMLQTLNEEPPTPEPAVEPPRTPELKQGLYELSAGNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLDSLREYVQSQLQSAGPAAPEPTQPSEAPALAAEPAADQGTVLALTERNFDDAIAEGVTFIKFYAPWCGHCKDLAPTWEDLSKKEFPGLAEVTIAEVDCTAERNLCSKYSVRGYPTLLLFRGGEKVGEHSGSRDLDSLHRFVLRQAKDEL", "length": 437, "header": "tr|A0A3Q1LUG9-1|A0A3Q1LUG9_BOVIN Isoform 1 of Thioredoxin domain-containing protein 5 OS=Bos taurus OX=9913 GN=TXNDC5 PE=1 SV=1 CANONICAL=A0A3Q1LUG9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUG9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9/entry", "sequence": { "sequence": "MPARAGRLLPPRPRALAPAMPPPLLLLLLLLLDAGGGRGGARAQEPGSAAADGPPAAGGGGGQDPHAKHLYTADMFAHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLADKYNSLEDAKVYVAKVDCTADSEVCSAQGVRGYPTLKFFKPGQEAVKYQGPRDFQALEKWMLQTLNEEPPTPEPAVEPPRTPELKQGLYELSAGNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLDSLREYVQSQLQSAGPAAPEPTQPSEAPALAAEPAADQGTVLALTERNFDDAIAEGVTFIKFYAPWCGHCKDLAPTWEDLSKKEFPGLAEVTIAEVDCTAERNLCSKYSVRGYPTLLLFRGGEKVGEHSGSRDLDSLHRFVLRQAKDEL", "length": 437, "header": "tr|A0A3Q1LUG9-1|A0A3Q1LUG9_BOVIN Isoform 1 of Thioredoxin domain-containing protein 5 OS=Bos taurus OX=9913 GN=TXNDC5 PE=1 SV=1 CANONICAL=A0A3Q1LUG9-1" }, "locus": { "chromosome": "23", "start_pos": 47500800, "end_pos": 47476544, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076880.1", "url": "https://www.ensembl.org/id/ENSBTAT00000076880.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064179.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064179.1" } ] } }, { "isoform_ac": "A0ABI0NR06-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NR06/entry", "sequence": { "sequence": "SLKFFKPGQEAVKYQGPRDFQALEKWMLQTLNEEPPTPEPAVEPPRTPELKQGLYELSAGNFELHVAQGRRAGVRACVTRGGPQPWGKALGETDWVCGLSLQVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLDSLREYVQSQLQSAGPAAPEPTQPSEAPALAAEPAADQGTVLALTERNFDDAIAEGVTFIKFYAPWCGHCKDLAPTWEDLSKKEFPGLAEVTIAEVDCTAERNLCSKYSVGPHGRSLLGTERGWGGSQGDCDGVASSEVTHAALLLSTKCSCPFERLEVFSFLI", "length": 305, "header": "tr|A0ABI0NR06-1|A0ABI0NR06_BOVIN Computationally mapped isoform of Thioredoxin domain containing 5 OS=Bos taurus OX=9913 GN=TXNDC5 PE=1 SV=1 CANONICAL=A0A3Q1LUG9-1" }, "locus": { "chromosome": "23", "start_pos": 47499788, "end_pos": 47484884, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136801.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136801.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104898.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104898.1" } ] } }, { "isoform_ac": "A0ABI0NUQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUQ9/entry", "sequence": { "sequence": "MEDAKVYVAKVDCTADSEVCSAQGVRGYPTLKFFKPGQEAVKYQGPRDFQALEKWMLQTLNEEPPTPEPAVEPPRTPELKQGLYELSAGNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLDSLREYVQSQLQSAGPAAPEPTQPSEAPALAAEPAADQGTVLALTERNFDDAIAEGVTFIKFYAPWCGHCKDLAPTWEDLSKKEFPGLAEVTIAEVDCTAERNLCSKYSVRGYPTLLLFRGGEKVGEHSGSRDLDSLHRFVLRQAKDEL", "length": 324, "header": "tr|A0ABI0NUQ9-1|A0ABI0NUQ9_BOVIN Computationally mapped isoform of protein disulfide-isomerase OS=Bos taurus OX=9913 GN=TXNDC5 PE=1 SV=1 CANONICAL=A0A3Q1LUG9-1" }, "locus": { "chromosome": "23", "start_pos": 47500800, "end_pos": 47480017, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148220.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148220.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107542.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107542.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 179, "start_aa": "Thr", "end_pos": 179, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr179", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:615027", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615027", "resource": "KEGG Pathway" }, { "id": "R-BTA-432720", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432720", "resource": "Reactome", "description": "Lysosome Vesicle Biogenesis" }, { "id": "R-BTA-432722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "resource": "Reactome", "description": "Golgi Associated Vesicle Biogenesis" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y726-1", "protein_name": "Thioredoxin domain-containing protein 5", "gene_name": "TXNDC5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASLRSGPAWCRLLAWAALGPVLCGGSMQAEPEPGEEPEADPHARHLYSAEMLRHGAAAAPHFVMFFAPWCGHCQRLQPTWNDLGDKYNNMENPQVYVVKVDCTADTPLCSEFGVRGYPTLKLLKPGQEPLKYQGPRDFQALENWMLEKLNGEPSDPESAVEPPKAPEPKQGMYELSADNFKTHIAEGNHFIKFFAPWCGHCKALAPTWEQLALAFEHSETVKIGKVDCTQHYEVCSENQVRGYPTLLWFRNGEKGDQYKGKRDFDSLKEYVDSQLQNSGKEPPASKPTEAPQPPAEPTQAEQAAVLSLSEKDFDETIARGITFIKFYAPWCGHCKNLAPTWESLAKEQFPGLTDVKIAEVDCTVERNVCNRFSVRGYPTLLLFRGGKKVSEHNGTRDLESLHSFVLRQARDEL", "length": 414 }, "evidence": [ { "id": "A0A3Q1LUG9", "url": "https://omabrowser.org/oma/group/A0A3Q1LUG9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0M279-1", "protein_name": "Thioredoxin domain-containing protein 5", "gene_name": "Txndc5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGDPRPRRELASPAAMPPRPGRLFQPLAGLPALATLLLLLGARKGARAQEVEADSGVEQDPHAKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTANSDVCSAQGVRGYPTLKFFKPGQEAVKYQGPRDFETLENWMLQTLNEEPATPEPEAEPPRAPELKQGLYELSANNFELHVSQGNHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYAVCSEHQVRGYPTLLWFRDGKKVDQYKGKRDLESLRDYVQSQLQGSEAAPETVEPSEAPVLAAEPPGDKGTVLALTEKSFEDTIAQGITFVKFYAPWCGHCKNLAPTWEELSKKEFPGLADVTIAEVDCTAERGVCSKYSVRGYPTLLLFRGGEKVGEHNGGRDLDSLHSFVLRQAKDEL", "length": 432 }, "evidence": [ { "id": "A0A3Q1LUG9", "url": "https://omabrowser.org/oma/group/A0A3Q1LUG9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1R184-1", "protein_name": "Thioredoxin domain-containing protein 5", "gene_name": "txndc5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKPFLTSFIYLALLCSRLSCDNDTEEDEHAKHTYTVEMFNDAISTAPHFVMFFAPWCGHCQRLQGTWNELADKYNSMEAPPAYVVKVDCTKDTKFCSIEHGIRGYPTLKLFKPEQEAVKYQGPRDLQALENWMLKTLQEEPEEPQSEPEPPKVPEPKQGLYELTATNFKSHIAKGSHFVKFFAPWCGHCKAMAPTWEQLASSFEHSDSIKISKVDCTQHYEVCSDNQVRGYPTLLFFTDGEKIDQYKGKRDLDSFKEFVDNHVKAAESKDEPEKEEEHTHEIPPSAEPEKQESNVLVLTESNFDETVAKGLSFIKFYAPWCGHCKNLAPTWDDLSQKEFPGLTDVKIAKVDCTVERTLCNRFSVRGYPTLLMFRAGQQGEEHNGGRDLESLHSFIMKQARDEL", "length": 403 }, "evidence": [ { "id": "A0A3Q1LUG9", "url": "https://omabrowser.org/oma/group/A0A3Q1LUG9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8NBS9-1", "protein_name": "Thioredoxin domain-containing protein 5", "gene_name": "TXNDC5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPARPGRLLPLLARPAALTALLLLLLGHGGGGRWGARAQEAAAAAADGPPAADGEDGQDPHSKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQAKDEL", "length": 432 }, "evidence": [ { "id": "A0A3Q1LUG9", "url": "https://omabrowser.org/oma/group/A0A3Q1LUG9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91W90-1", "protein_name": "Thioredoxin domain-containing protein 5", "gene_name": "Txndc5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPPRPGRLLQPLAGLPALATLLLLLGARKGARAQEVEADSGVEQDPHAKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTADSDVCSAQGVRGYPTLKFFKPGQEAVKYQGPRDFETLENWMLQTLNEEPATPEPEAEPPRAPELKQGLYELSANNFELHVSQGNHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYAVCSEHQVRGYPTLLWFRDGKKVDQYKGKRDLESLRDYVQSQLQGSEAAPETVEPSEAPVMAAEPTGDKGTVLALTEKSFEDTIAQGITFVKFYAPWCGHCKNLAPTWEELSKKEFPGLSDVTIAEVDCTAERNVCSKYSVRGYPTLLLFRGGEKVGEHNGGRDLDSLHSFVLRQAKDEL", "length": 417 }, "evidence": [ { "id": "A0A3Q1LUG9", "url": "https://omabrowser.org/oma/group/A0A3Q1LUG9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VYV3-1", "protein_name": "Thioredoxin domain-containing protein 5 homolog", "gene_name": "prtp", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLTRSILSVAVCGLLLSPLLPITRASQEEDTGKQDKQFTVELDPETFDTAIAGGNVFVKFFAPWCGHCKRIQPLWEQLAEIMNVDNPKVIIAKVDCTKHQGLCATHQVTGYPTLRLFKLGEEESVKFKGTRDLPAITDFINKELSAPAEADLGEVKREQVENLNIGKVVDLTEDTFAKHVSTGNHFVKFFAPWCSHCQRLAPTWEDLAKELIKEPTVTISKIDCTQFRSICQDFEVKGYPTLLWIEDGKKIEKYSGARDLSTLKTYVEKMVGVPLEKTAGEAGDEKVVIEEVAGEEDAAKKLTPQQLTGEDEFDQAIAEGVAFIKFYAPWCGHCQKLQPTWEQLATETHQAQSSVKIAKVDCTAPENKQVCIDQQVEGYPTLFLYKNGQRQNEYEGSRSLPELQAYLKKFLGHDEL", "length": 416 }, "evidence": [ { "id": "A0A3Q1LUG9", "url": "https://omabrowser.org/oma/group/A0A3Q1LUG9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUG9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ], "pmid": "" }, { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUG9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUG9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUG9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUG9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-disulfide reductase activity", "id": "GO:0015035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015035", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUG9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ], "pmid": "" }, { "name": "protein disulfide isomerase activity", "id": "GO:0003756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003756", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUG9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-429815", "name": "Formation Of Bloc-1 Complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LUG9-1", "Q2NKW0-1" ], "evidence": [ { "id": "R-BTA-429815", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-429815" } ] }, { "id": "R-BTA-432706", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi membrane, cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P84080-1", "A0ABI0NJH4-1", "F1MZ33-1", "P05689-1", "A0A3Q1LUG9-1", "Q2NKW0-1" ], "evidence": [ { "id": "R-BTA-432706", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432706" } ] }, { "id": "R-BTA-432707", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0ABI0NJH4-1", "F1MZ33-1", "P05689-1", "A0A3Q1LUG9-1", "Q2NKW0-1" ], "evidence": [ { "id": "R-BTA-432707", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432707" } ] }, { "id": "R-BTA-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, azurophil granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O77834-1", "Q29451-1", "P07514-1", "A0JNA3-1", "Q32PF2-1", "Q3MI05-1", "F1MUP9-1", "H7BWW2-1", "Q08DD1-1", "Q2KIM0-1", "Q3ZBH0-1", "F1MU24-1", "A0AAA9U1E9-1", "A0ABI0NJH4-1", "F1N144-1", "F1N5H2-1", "P80189-1", "P46196-1", "A7YWG4-1", "E1BPI3-1", "A0AAA9SWY4-1", "A0A3Q1LUG9-1", "F1MGY9-1", "G3X757-1", "A0A3Q1NDQ7-1", "Q2KJ64-1", "Q3ZCI9-1", "E1B725-1" ], "evidence": [ { "id": "R-BTA-6798751", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798751" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUG9", "gene_name": "TXNDC5", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "A0A3Q1LUG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "A0A3Q1LUG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ] } ] }, { "uniprot_ac": "A0A3Q1NDQ7", "gene_name": "GLB1", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] } ] }, { "uniprot_ac": "A0AAA9SWY4", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] } ] }, { "uniprot_ac": "A0AAA9U1E9", "gene_name": "GALNS", "activity": [ { "ec_number": "3.1.6.4", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.", "evidence": [ { "id": "A0AAA9U1E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1E9" } ] }, { "ec_number": "3.1.6.4", "activity": "", "evidence": [ { "id": "A0AAA9U1E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1E9" } ] } ] }, { "uniprot_ac": "A0ABI0NJH4", "gene_name": "GNS", "activity": [ { "ec_number": "3.1.6.14", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] }, { "ec_number": "3.1.6.14", "activity": "", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] } ] }, { "uniprot_ac": "A0JNA3", "gene_name": "IMPDH1", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] } ] }, { "uniprot_ac": "A7YWG4", "gene_name": "GGH", "activity": [ { "ec_number": "3.4.19.9", "activity": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate.", "evidence": [ { "id": "A7YWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWG4" } ] }, { "ec_number": "3.4.19.9", "activity": "", "evidence": [ { "id": "A7YWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWG4" } ] } ] }, { "uniprot_ac": "E1B725", "gene_name": "GLA", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "E1B725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ] } ] }, { "uniprot_ac": "E1BPI3", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] } ] }, { "uniprot_ac": "F1MGY9", "gene_name": "AGA", "activity": [ { "ec_number": "3.5.1.26", "activity": "N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+).", "evidence": [ { "id": "F1MGY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGY9" } ] }, { "ec_number": "3.5.1.26", "activity": "", "evidence": [ { "id": "F1MGY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGY9" } ] } ] }, { "uniprot_ac": "F1MU24", "gene_name": "PYGB", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "F1MU24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU24" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "F1MU24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU24" } ] } ] }, { "uniprot_ac": "F1MUP9", "gene_name": "VAT1", "activity": [ { "ec_number": "1.6.5.5", "activity": "2 1,2-naphthoquinone + NADPH + H(+) = 2 1,2-naphthosemiquinone + NADP(+).", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] }, { "ec_number": "1.6.5.5", "activity": "", "evidence": [ { "id": "F1MUP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUP9" } ] } ] }, { "uniprot_ac": "F1MZ33", "gene_name": "DNASE2", "activity": [ { "ec_number": "3.1.22.1", "activity": "Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.", "evidence": [ { "id": "F1MZ33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZ33" } ] }, { "ec_number": "3.1.22.1", "activity": "", "evidence": [ { "id": "F1MZ33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZ33" } ] } ] }, { "uniprot_ac": "F1N144", "gene_name": "ADA2", "activity": [ { "ec_number": "3.5.4.4", "activity": "2'-deoxyadenosine + H2O + H(+) = 2'-deoxyinosine + NH4(+).", "evidence": [ { "id": "F1N144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N144" } ] }, { "ec_number": "3.5.4.4", "activity": "", "evidence": [ { "id": "F1N144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N144" } ] } ] }, { "uniprot_ac": "F1N5H2", "gene_name": "FUCA2", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = L-fucose + an alcohol.", "evidence": [ { "id": "F1N5H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5H2" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "F1N5H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5H2" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "H7BWW2", "gene_name": "HEXB", "activity": [ { "ec_number": "3.2.1.52", "activity": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.", "evidence": [ { "id": "H7BWW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H7BWW2" } ] }, { "ec_number": "3.2.1.52", "activity": "", "evidence": [ { "id": "H7BWW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H7BWW2" } ] } ] }, { "uniprot_ac": "O77834", "gene_name": "PRDX6", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] }, { "ec_number": "2.3.1.23", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "O77834", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O77834" } ] } ] }, { "uniprot_ac": "P05689", "gene_name": "CTSZ", "activity": [ { "ec_number": "3.4.18.1", "activity": "Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.", "evidence": [ { "id": "P05689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05689" } ] }, { "ec_number": "3.4.18.1", "activity": "", "evidence": [ { "id": "P05689", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05689" } ] } ] }, { "uniprot_ac": "P07514", "gene_name": "CYB5R3", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+).", "evidence": [ { "id": "P07514", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07514" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "P07514", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P07514" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P80189", "gene_name": "LYS", "activity": [ { "ec_number": "3.2.1.17", "activity": "Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.", "evidence": [ { "id": "P80189", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80189" } ] }, { "ec_number": "3.2.1.17", "activity": "", "evidence": [ { "id": "P80189", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P80189" } ] } ] }, { "uniprot_ac": "P84080", "gene_name": "ARF1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P84080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84080" } ] } ] }, { "uniprot_ac": "Q08DD1", "gene_name": "ARSA", "activity": [ { "ec_number": "3.1.6.8", "activity": "an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + H2O = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + sulfate + H(+).", "evidence": [ { "id": "Q08DD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DD1" } ] }, { "ec_number": "3.1.6.8", "activity": "", "evidence": [ { "id": "Q08DD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DD1" } ] } ] }, { "uniprot_ac": "Q29451", "gene_name": "MAN2B1", "activity": [ { "ec_number": "3.2.1.24", "activity": "Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.", "evidence": [ { "id": "Q29451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29451" } ] }, { "ec_number": "3.2.1.24", "activity": "", "evidence": [ { "id": "Q29451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29451" } ] } ] }, { "uniprot_ac": "Q2KIM0", "gene_name": "FUCA1", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = L-fucose + an alcohol.", "evidence": [ { "id": "Q2KIM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIM0" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "Q2KIM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIM0" } ] } ] }, { "uniprot_ac": "Q2KJ64", "gene_name": "ARG1", "activity": [ { "ec_number": "3.5.3.1", "activity": "L-arginine + H2O = urea + L-ornithine.", "evidence": [ { "id": "Q2KJ64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ64" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "Q2KJ64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ64" } ] } ] }, { "uniprot_ac": "Q2NKW0", "gene_name": "BLOC1S1", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q2NKW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKW0" } ] } ] }, { "uniprot_ac": "Q32PF2", "gene_name": "ACLY", "activity": [ { "ec_number": "2.3.3.8", "activity": "oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA.", "evidence": [ { "id": "Q32PF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF2" } ] }, { "ec_number": "2.3.3.8", "activity": "", "evidence": [ { "id": "Q32PF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PF2" } ] } ] }, { "uniprot_ac": "Q3MI05", "gene_name": "CTSA", "activity": [ { "ec_number": "3.4.16.5", "activity": "Release of a C-terminal amino acid with broad specificity.", "evidence": [ { "id": "Q3MI05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MI05" } ] }, { "ec_number": "3.4.16.5", "activity": "", "evidence": [ { "id": "Q3MI05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MI05" } ] }, { "ec_number": "3.4.16.-", "activity": "", "evidence": [ { "id": "Q3MI05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MI05" } ] } ] }, { "uniprot_ac": "Q3ZBH0", "gene_name": "CCT2", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZBH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBH0" } ] } ] }, { "uniprot_ac": "Q3ZCI9", "gene_name": "CCT8", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3ZCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCI9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LUG9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 437, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": 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"refseq": { "ac": "NP_001377613", "name": "olfactory receptor family 8 subfamily J member 3", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377613" }, "gene_names": [ { "name": "OR8J3", "type": "recommended", "evidence": [ { "id": "A0A3Q1LUL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUL7" } ] }, { "name": "OR8J3", "type": "synonym", "evidence": [ { "id": "NP_001377613", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377613" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0A3Q1LUL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUL7/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 8J3", "type": "synonym", "evidence": [ { "id": "NP_001377613", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377613" } ] }, { "name": "olfactory receptor family 8 subfamily J member 3", "type": "synonym", "evidence": [ { "id": "NP_001377613", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377613" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377613" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUL7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUL7#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUL7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUL7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8J3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUL7", "locus": { "chromosome": "15", "start_pos": 79651561, "end_pos": 79650608, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000052893", "url": "https://www.ensembl.org/id/ENSBTAG00000052893" } ] } } ], "crossref": [ { "id": "A0A3Q1LUL7", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LUL7", "database": "AlphaFoldDB", "categories": [] }, { "id": "100300446", "url": "https://www.ncbi.nlm.nih.gov/gene/100300446", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100300446", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100300446", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VSYCIFS", "url": "https://omabrowser.org/oma/group/VSYCIFS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUL7", "url": "https://www.orthodb.org/?gene=A0A3Q1LUL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377613", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUL7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUL7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANGNFTRVIEFILTGVSEHPDLQIPLFFVFLVIYGLTVTGNLSIITLTSVDSRLQTPMYFFLRHLAIINLGNSTVIAPKMLISFLVKKHTTSYYECATQLGGFLVFIVAEVLLLAVMAYDRYVAICNPLLYMAVVSRRICLLLVSLTYLYSFSTAIVASSSVFSVTYCSCNIINHFYCDIAPLLALSCSDTSFPETFVFISAATNLAFSIIIVLISYFNIVLSILKIRSSEGRKKAFSTCASHMMAVSVFYGTMIFMYAQPQTNHSMDTDKVASVFYTLVIPMLNPMIYSLRNKDVKAALKRFLTNSCCSFKLMQF", "length": 317, "header": "tr|A0A3Q1LUL7-1|A0A3Q1LUL7_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8J3 PE=3 SV=1 CANONICAL=A0A3Q1LUL7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUL7/entry", "sequence": { "sequence": 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"MAPRNLSHITEFILVGVSDLPELQVPLFFVFLIIYLLTAAGNLGIITLTTVDSRLQTPMYFFLRHLAVINFGNSTVIAPKMLVNFLVTEKTTLYYECATQLGGFLVFIVAEIFMLAVMAYDRYVAICNPLLYMVVVSRRVCLLLMSLTYFYGFCTAIVVSSCVFSVSYCSSKKINHFYCDNVPLLALSCSDTYLPETVVFISAATNLFFSMSIVLVSYFNIVLSILRIRSSEGRKKAFSTCASHMMAVTVFYGTLLFMYLQPQTNHSLDTDKMASVFYTLVIPMLNPMIYSLRNKDVKAALKKFITNPCDSFKSL", "length": 315 }, "evidence": [ { "id": "A0A3Q1LUL7", "url": "https://omabrowser.org/oma/group/A0A3Q1LUL7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TR80-1", "protein_name": "Olfactory receptor", "gene_name": "Or8j3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPRNLSHVTEFILVGVSDLPELQVPLFFVFLVIYLLTAAGNLGIITLTSVDSRLQTPMYFFLRHLAVINFGNSTVIAPKMLVNFLVSKKTTLYYECATQLGGFLVFIVAEIFMLAVMAYDRYVAICNPLLYMVVVSRRVCLLLVSLTYFYGFCTAIVVSSCVFSVSYCSSKKINHFYCDNVPLLALSCSDTYLPETVVFISAATNLFFSMSIVLVSYFNIVLSILRIRSAEGRKKAFSTCASHVMAVTVFYGTLLFMYLQPQTNHSLDTDKMASVFYTLVIPMLNPMIYSLRNKDVKAALKRFMTSPCDSFKSL", "length": 315 }, "evidence": [ { "id": "A0A3Q1LUL7", "url": "https://omabrowser.org/oma/group/A0A3Q1LUL7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NGG0-1", "protein_name": "Olfactory receptor 8J3", "gene_name": "OR8J3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPENFTRVTEFILTGVSSCPELQIPLFLVFLVLYVLTMAGNLGIITLTSVDSRLQNPMYFFLRHLAIINLGNSTVIAPKMLMNFLVKKKTTSFYECATQLGGFLFFIVSEVMMLAVMAYDRYVAICNPLLYMVVVSRRLCLLLVSLTYLYGFSTAIVVSPCIFSVSYCSSNIINHFYCDIAPLLALSCSDTYIPETIVFISAATNLVFSMITVLVSYFNIVLSILRIRSPEGRKKAFSTCASHMIAVTVFYGTMLFMYLQPQTNHSLDTDKMASVFYTLVIPMLNPLIYSLRNNDVNVALKKFMENPCYSFKSM", "length": 315 }, "evidence": [ { "id": "A0A3Q1LUL7", "url": "https://omabrowser.org/oma/group/A0A3Q1LUL7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", 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Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation. Required for retinal integrity. Acts as a positive regulator of centriole elongation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MAE7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAE7#function" }, { "database": "UniProtKB", "id": "ARBA00059354", "url": "https://www.uniprot.org/uniprotkb/ARBA00059354#function" }, { "database": "UniProtKB", "id": "A0AAA9S0T0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0T0#function" }, { "database": "UniProtKB", "id": "A0A3Q1LUP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6#function" }, { "database": "UniProtKB", "id": "F6QTD1", "url": "https://www.uniprot.org/uniprotkb/F6QTD1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POC1B", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6", "locus": { "chromosome": "5", "start_pos": 19295432, "end_pos": 19400102, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000687", "url": "https://www.ensembl.org/id/ENSBTAG00000000687" } ] } } ], "crossref": [ { "id": "A0A3Q1LUP6", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LUP6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000687", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000687", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525136", "url": "https://www.ncbi.nlm.nih.gov/gene/525136", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050505", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050505", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUP6", "url": "https://www.orthodb.org/?gene=A0A3Q1LUP6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MAE7", "url": "https://www.orthodb.org/?gene=A0A3Q1MAE7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MJK6", "url": "https://www.orthodb.org/?gene=A0A3Q1MJK6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44019", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44019", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44019:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44019:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LUP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUP6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAE7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAE7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAE7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJK6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJK6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJK6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0T0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0T0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0T0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0T0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QTD1", "url": "https://www.uniprot.org/uniprotkb/F6QTD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QTD1-1", "url": "https://www.uniprot.org/uniprotkb/F6QTD1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "FPSQEDPVLERYFKGHKAAITSVDFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIRLWIPDKRGKSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWRTNFDELNYKDVSKRNLKRLHFDSPPHLLDIYPRTPHPHEGRIDTVEINPKLDVTDLQTSTPPVVDILSFDSTTTTETTVRTLPDKGEEICGYFLNPSLMSSECSPTILKKKTEDISDLPSESQRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFNAIQQKI", "length": 477, "header": "tr|A0A3Q1LUP6-1|A0A3Q1LUP6_BOVIN Isoform 1 of POC1 centriolar protein homolog B OS=Bos taurus OX=9913 GN=POC1B PE=3 SV=2 CANONICAL=A0A3Q1LUP6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUP6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6/entry", "sequence": { "sequence": "FPSQEDPVLERYFKGHKAAITSVDFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIRLWIPDKRGKSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWRTNFDELNYKDVSKRNLKRLHFDSPPHLLDIYPRTPHPHEGRIDTVEINPKLDVTDLQTSTPPVVDILSFDSTTTTETTVRTLPDKGEEICGYFLNPSLMSSECSPTILKKKTEDISDLPSESQRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFNAIQQKI", "length": 477, "header": "tr|A0A3Q1LUP6-1|A0A3Q1LUP6_BOVIN Isoform 1 of POC1 centriolar protein homolog B OS=Bos taurus OX=9913 GN=POC1B PE=3 SV=2 CANONICAL=A0A3Q1LUP6-1" }, "locus": { "chromosome": "5", "start_pos": 19399363, "end_pos": 19296486, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076347.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076347.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060880.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060880.2" } ] } }, { "isoform_ac": "A0A3Q1MAE7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAE7/entry", "sequence": { "sequence": "MASSPEDPVLERYFKGHKAAITSVDFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIRLWIPDKRGKSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWRTNFDELNYKDVSKRNLKRLHFDSPPHLLDIYPRTPHPHEGRIDTVETTETTVRTLPDKGEEICGYFLNPSLMSSECSPTILKKKTEDISDLPSESQRSIPLAVTDALEHIMEQLNVLTQCFVLWWVAEMEQVLELISEPTSWQEDCFNLGAATDFDRG", "length": 456, "header": "tr|A0A3Q1MAE7-1|A0A3Q1LUP6_BOVIN Computationally mapped isoform of POC1 centriolar protein homolog B OS=Bos taurus OX=9913 GN=POC1B PE=3 SV=2 CANONICAL=A0A3Q1LUP6-1" }, "locus": { "chromosome": "5", "start_pos": 19400023, "end_pos": 19296547, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079434.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079434.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067578.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067578.2" } ] } }, { "isoform_ac": "A0A3Q1MJK6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJK6/entry", "sequence": { "sequence": "MCVVIFLIRSNTNLAATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIRLWIPDKRGKSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWRTNFDELNYKDVSKRNLKRLHFDSPPHLLDIYPRTPHPHEGRIDTVEINPKLDVTDLQTSTPPVVDILSFDSTTTTETTVRTLPDKGEEICGYFLNPSLMSSECSPTILKKKTEDISDLPSESQRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFNAIQQKI", "length": 460, "header": "tr|A0A3Q1MJK6-1|A0A3Q1LUP6_BOVIN Computationally mapped isoform of POC1 centriolar protein homolog B OS=Bos taurus OX=9913 GN=POC1B PE=3 SV=2 CANONICAL=A0A3Q1LUP6-1" }, "locus": { "chromosome": "5", "start_pos": 19392510, "end_pos": 19296486, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067805.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067805.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070972.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070972.2" } ] } }, { "isoform_ac": "A0AAA9S0T0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0T0/entry", "sequence": { "sequence": "MASSPEDPVLERYFKGHKAAITSVDFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIRLWIPDKRGKSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFTSGGADAQVLLWRTNFDELNYKDVSKRNLKRLHFDSPPHLLDIYPRTPHPHEGRIDTVETTETTVRTLPDKGEEICGYFLNPSLMSSECSPTILKKKTEDISDLPSESQRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFNAIQQKI", "length": 451, "header": "tr|A0AAA9S0T0-1|A0A3Q1LUP6_BOVIN Computationally mapped isoform of POC1 centriolar protein homolog B OS=Bos taurus OX=9913 GN=POC1B PE=3 SV=1 CANONICAL=A0A3Q1LUP6-1" }, "locus": { "chromosome": "5", "start_pos": 19400023, "end_pos": 19296486, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089610.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089610.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075677.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075677.1" } ] } }, { "isoform_ac": "F6QTD1-1", "url": "https://www.uniprot.org/uniprotkb/F6QTD1/entry", "sequence": { "sequence": "MASSPEDPVLERYFKGHKAAITSVDFSPNGKQLATGSWDTFLMLWSLRPQARAFRYVGHKDVITSVQFSPLGNLLASASRDRTIRLWIPDKRGKSSEFKAHTAPVRSVDFSADGQFLASASEDKSIKVWNMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDFVGFANFVAFNPNGTCIASAGSDHTVKIWDIRVNKLLQHYQVHSGGVNCVSFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTVLLWRTNFDELNYKDVSKRNLKRLHFDSPPHLLDIYPRTPHPHEGRIDTVEINPKLDVTDLQTSTPPVVDILSFDSTTTTETTVRTLPDKGEEICGYFLNPSLMSSECSPTILKKKTEDISDLPSESQRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFNAIQQKI", "length": 455, "header": "tr|F6QTD1-1|A0A3Q1LUP6_BOVIN Computationally mapped isoform of POC1 centriolar protein homolog B OS=Bos taurus OX=9913 GN=POC1B PE=3 SV=1 CANONICAL=A0A3Q1LUP6-1" }, "locus": { "chromosome": "5", "start_pos": 19400023, "end_pos": 19296486, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000919.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000919.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000919.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000919.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "cell population proliferation", "id": "GO:0008283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6" } ], "pmid": "" }, { "name": "retina homeostasis", "id": "GO:0001895", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001895", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6" } ], "pmid": "" }, { "name": "positive regulation of centriole elongation", "id": "GO:1903724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903724", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6" } ], "pmid": "" }, { "name": "centriole replication", "id": "GO:0007099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007099", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6" } ], "pmid": "" }, { "name": "microtubule-based process", "id": "GO:0007017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007017", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6" } ], "pmid": "" }, { "name": "multicellular organismal-level homeostasis", "id": "GO:0048871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048871", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LUP6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUP6" } ], "pmid": 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[provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377753" }, "gene_names": [ { "name": "OR7A115", "type": "recommended", "evidence": [ { "id": "A0A3Q1LV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV00" } ] }, { "name": "OR7A115", "type": "synonym", "evidence": [ { "id": "NP_001377753", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377753" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0A3Q1LV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV00/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 7 subfamily A member 115", "type": "synonym", "evidence": [ { "id": "NP_001377753", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377753" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. 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"strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000066662", "url": "https://www.ensembl.org/id/ENSBTAG00000066662" } ] } } ], "crossref": [ { "id": "A0A3Q1LV00", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LV00", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000052896", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052896", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15234", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15234", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "119646106", "url": "https://www.ncbi.nlm.nih.gov/gene/119646106", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:119646106", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:119646106", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377753", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV00", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV00-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQNCRISTLLQCQFQIKLVMSFVFFVFFFFFFFVCLFPGSHLYYMELGNDTEISEFLLLGFSQEPELQALIFGLFLSMYLITVFGNLLIILAVSSDAHLHTPMYFFLTNLSFVDICFTSTTIPKMLWNVQTQSKVITYEGCITQIYFFLLSAVLDIFLLTVMAYDRFVAICHPLHYMVIMNPRLCFLLVLVSWTISILNSLLQSLILLQLSFCTVVEIPDFFCDLSQIIQLACSDTFLNNMVMYLTVVLLSSGPLAGILYSYSKIVSCICRISSVQGKYKAFSICASHLSVVSLFFCTSLGVYLSSPATHSSHSSATASVMYTVVTPMLNPFIYSLRNKDIKGALKRFFMMASLKRSVILDLEKCPRLQISKSQNK", "length": 376, "header": "tr|A0A3Q1LV00-1|A0A3Q1LV00_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR7A115 PE=3 SV=2 CANONICAL=A0A3Q1LV00-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LV00-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV00/entry", "sequence": { "sequence": "MQNCRISTLLQCQFQIKLVMSFVFFVFFFFFFFVCLFPGSHLYYMELGNDTEISEFLLLGFSQEPELQALIFGLFLSMYLITVFGNLLIILAVSSDAHLHTPMYFFLTNLSFVDICFTSTTIPKMLWNVQTQSKVITYEGCITQIYFFLLSAVLDIFLLTVMAYDRFVAICHPLHYMVIMNPRLCFLLVLVSWTISILNSLLQSLILLQLSFCTVVEIPDFFCDLSQIIQLACSDTFLNNMVMYLTVVLLSSGPLAGILYSYSKIVSCICRISSVQGKYKAFSICASHLSVVSLFFCTSLGVYLSSPATHSSHSSATASVMYTVVTPMLNPFIYSLRNKDIKGALKRFFMMASLKRSVILDLEKCPRLQISKSQNK", "length": 376, "header": "tr|A0A3Q1LV00-1|A0A3Q1LV00_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR7A115 PE=3 SV=2 CANONICAL=A0A3Q1LV00-1" }, "locus": { "chromosome": "7", "start_pos": 10417389, "end_pos": 10416262, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073716.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073716.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061192.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061192.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:119646106", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:119646106", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV00", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV00" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV00", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV00" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV00", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV00" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV00", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV00" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LV00-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 376, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LV00-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LV00" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LV00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV00" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 85, "end_pos": 334, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 49, "end_pos": 51 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LXH8-1", "uniprot_ac": "A0A3Q1LXH8", "uniprot_id": "A0A3Q1LXH8_BOVIN", "mass": { "chemical_mass": 83435.0, "monoisotopic_mass": 83435.0 }, "refseq": { "ac": "XP_024838895", "name": "urocanate hydratase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838895" }, "gene_names": [ { "name": "UROC1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LXH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8" } ] }, { "name": "UROC1", "type": "synonym", "evidence": [ { "id": "XP_024838895", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838895" } ] } ], "protein_names": [ { "name": "Urocanate hydratase", "type": "recommended", "evidence": [ { "id": "A0A3Q1LXH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8/entry#names_and_taxonomy" } ] }, { "name": "4.2.1.49", "type": "synonym", "evidence": [ { "id": "A0A3Q1LXH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8/entry#names_and_taxonomy" } ] }, { "name": "Imidazolonepropionate hydrolase", "type": "synonym", "evidence": [ { "id": "A0A3Q1LXH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8/entry#names_and_taxonomy" } ] }, { "name": "urocanate hydratase isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024838895", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838895" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXH8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UROC1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8", "locus": { "chromosome": "22", "start_pos": 60491195, "end_pos": 60462566, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008774", "url": "https://www.ensembl.org/id/ENSBTAG00000008774" } ] } } ], "crossref": [ { "id": "A0A3Q1LXH8", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LXH8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008774", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008774", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100336419", "url": "https://www.ncbi.nlm.nih.gov/gene/100336419", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR023636", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023636", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023637", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023637", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035085", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035085", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035400", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035400", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055351", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055351", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12216", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12216", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12216:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12216:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01175", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01175", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17391", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17391", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17392", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17392", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-70921", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70921", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024838895", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838895", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13101", "url": "https://www.rhea-db.org/rhea/13101", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LV31", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV31-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV31-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXH7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXH7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXH8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXH8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCSLQELCSGLPLRPLPENRGRRAGVPHAPVRTPGLSPAEEQLALKNALRYFPPDVQEVLAPEFAQELRLYGHIYMYRFCPDLEMRAYPVERYPCRTRAAAAIMLMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLTMSYLAQMTEEQTLVMYSGHPLGLFPSSPEAPRLVITNGMVIPNYSSRTEYEKLFAMGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAGRRYLGLQDLAGKVFVTSGLGGMSGAQAKAAVIVGCIGVIAEVDGAALMKRHRQGWLMEVTDSLDRCIERLREARKRKEVLSLGYHGNVVDLWERLVHELDTTGELLVDLGSDQTSCHNPFNGGYYPVQLGFAEAQSLMASDPTAFKSLVQESLRRHVSAINRLAREHFFFWDYGNAFLLEAQRAGADVGKPGANRTEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDRLATSALEEIVAAGVTPAVKLQYVDNIRWIQEAAKHQLVVGSQARILYSDQKGRVAIAVAFNQAIARGELKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDAFRGATWIALHNGGGVGWGEVINGGFGLVLDGTEDAEQKARRVLSWDVANGVSDRQHPPRLSPVQTADPPPSGKVCSPPAAAVSPPATARVALHGRQPALHPGCVLSSLCPWGLGSVPFPTLRLCASESTAAHARVCPDAVARRCWSGSPMAYEVICQTMREDSGMVVTLPHAVTDERLLQALRL", "length": 764, "header": "tr|A0A3Q1LXH8-1|A0A3Q1LXH8_BOVIN Isoform 1 of Urocanate hydratase OS=Bos taurus OX=9913 GN=UROC1 PE=1 SV=2 CANONICAL=A0A3Q1LXH8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LV31-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV31/entry", "sequence": { "sequence": "MPPRAPVPSCAPRAPPTPSLRAVCTFLLGALLSGLPPWSAGPEVAPGTRQKLDPETLRWPPDAPDPLLALKNALRYFPPDVQEVLAPEFAQELRLYGHIYMYRFCPDLEMRAYPVERYPCRTRAAAAIMLMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLTMSYLAQMTEEQTLVMYSGHPLGLFPSSPEAPRLVITNGMVIPNYSSRTEYEKLFAMGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAGRRYLGLQDLAGKVFVTSGLGGMSGAQAKAAVIVGCIGVIAEVDGAALMKRHRQGWLMEVTDSLDRCIERLREARKRKEVLSLGYHGNVVDLCLRRHVSAINRLAREHFFFWDYGNAFLLEAQRAGADVGKPGANRTEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDRLATSALEEIVAAGVTPAVKLQYVDNIRWIQEAAKHQLVVGSQARILYSDQKGRVAIAVAFNQAIARGELKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDAFRGATWIALHNGGGVGWGEVINGGFGLVLDGTEDAEQKARRVLSWDVANGVSDRQHPPRLSPVQTADPPPSGKVCSPPAAAVSPPATARVALHGRQPALHPGCVLSSLCPWGLGSVPFPTLRLCASESTAAHARVCPDAVCGAGPHPRGTTYQGPKGEA", "length": 704, "header": "tr|A0A3Q1LV31-1|A0A3Q1LXH8_BOVIN Computationally mapped isoform of Urocanate hydratase OS=Bos taurus OX=9913 GN=UROC1 PE=1 SV=1 CANONICAL=A0A3Q1LXH8-1" }, "locus": { "chromosome": "22", "start_pos": 60489671, "end_pos": 60465798, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080592.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080592.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064447.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064447.1" } ] } }, { "isoform_ac": "A0A3Q1LXH7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH7/entry", "sequence": { "sequence": "MPPRAPVPSCAPRAPPTPSLRAVCTFLLGALLSGLPPWSAGPEVAPGTRQKLDPETLRWPPDAPDPLLALKNALRYFPPDVQEVLAPEFAQELRLYGHIYMYRFCPDLEMRAYPVERYPCRTRAAAAIMLMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLTMSYLAQMTEEQTLVMYSGHPLGLFPSSPEAPRLVITNGMVIPNYSSRTEYEKLFAMGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAGRRYLGLQDLAGKVFVTSGLGGMSGAQAKAAVIVGCIGVIAEVDGAALMKRHRQGWLMEVTDSLDRCIERLREARKRKEVLSLGYHGNVVDLWERLVHELDTTGELLVDLGSDQTSCHNPFNGGYYPVQLGFAEAQSLMASDPTAFKSLVQESLRRHVSAINRLAREHFFFWDYGNAFLLEAQRAGADVGKPGANRTEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDRLATSALEEIVAAGVTPAVKLQYVDNIRWIQEAAKHQLVVGSQARILYSDQKGRVAIAVAFNQAIARGELKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDAFRGATWIALHNGGGVGWGEVINGGFGLVLDGTEDAEQKARRVLSWDVANGVARRCWSGSPMAYEVICQTMREDSGMVVTLPHAVTDERLLQALRL", "length": 700, "header": "tr|A0A3Q1LXH7-1|A0A3Q1LXH7_BOVIN Computationally mapped isoform of Urocanate hydratase OS=Bos taurus OX=9913 GN=UROC1 PE=1 SV=2 CANONICAL=A0A3Q1LXH8-1" }, "locus": { "chromosome": "22", "start_pos": 60490191, "end_pos": 60465798, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083727.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083727.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062206.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062206.2" } ] } }, { "isoform_ac": "A0A3Q1LXH8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8/entry", "sequence": { "sequence": "MCSLQELCSGLPLRPLPENRGRRAGVPHAPVRTPGLSPAEEQLALKNALRYFPPDVQEVLAPEFAQELRLYGHIYMYRFCPDLEMRAYPVERYPCRTRAAAAIMLMIMNNLDPAVAQFPQELVTYGGNGQVFSNWAQFWLTMSYLAQMTEEQTLVMYSGHPLGLFPSSPEAPRLVITNGMVIPNYSSRTEYEKLFAMGVTMYGQMTAGSYCYIGPQGIVHGTVLTVLNAGRRYLGLQDLAGKVFVTSGLGGMSGAQAKAAVIVGCIGVIAEVDGAALMKRHRQGWLMEVTDSLDRCIERLREARKRKEVLSLGYHGNVVDLWERLVHELDTTGELLVDLGSDQTSCHNPFNGGYYPVQLGFAEAQSLMASDPTAFKSLVQESLRRHVSAINRLAREHFFFWDYGNAFLLEAQRAGADVGKPGANRTEFRYPSYVQHIMGDIFSQGFGPFRWVCTSGDPQDLAVTDRLATSALEEIVAAGVTPAVKLQYVDNIRWIQEAAKHQLVVGSQARILYSDQKGRVAIAVAFNQAIARGELKAPVVLSRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNFVGDAFRGATWIALHNGGGVGWGEVINGGFGLVLDGTEDAEQKARRVLSWDVANGVSDRQHPPRLSPVQTADPPPSGKVCSPPAAAVSPPATARVALHGRQPALHPGCVLSSLCPWGLGSVPFPTLRLCASESTAAHARVCPDAVARRCWSGSPMAYEVICQTMREDSGMVVTLPHAVTDERLLQALRL", "length": 764, "header": "tr|A0A3Q1LXH8-1|A0A3Q1LXH8_BOVIN Isoform 1 of Urocanate hydratase OS=Bos taurus OX=9913 GN=UROC1 PE=1 SV=2 CANONICAL=A0A3Q1LXH8-1" }, "locus": { "chromosome": "22", "start_pos": 60490191, "end_pos": 60462765, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068260.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068260.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060230.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060230.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 481, "start_aa": "Thr", "end_pos": 481, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr481", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-70921", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70921", "resource": "Reactome", "description": "Histidine catabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "urocanate hydratase activity", "id": "GO:0016153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016153", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXH8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "L-histidine catabolic process to glutamate and formamide", "id": "GO:0019556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019556", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXH8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8" } ], "pmid": "" }, { "name": "L-histidine catabolic process to glutamate and formate", "id": "GO:0019557", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019557", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXH8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8" } ], "pmid": "" }, { "name": "L-histidine catabolic process", "id": "GO:0006548", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006548", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXH8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXH8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 424, "end_pos": 426, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13101", "name": "", "equation": "4-imidazolone-5-propanoate = trans-urocanate + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LXH8-1" ], "evidence": [ { "id": "13101", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13101" } ] }, { "id": "R-BTA-70903", "name": "urocanate + H2O => 4-imidazolone-5-propanoate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LXH8-1" ], "evidence": [ { "id": "R-BTA-70903", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70903" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LXH8", "gene_name": "UROC1", "activity": [ { "ec_number": "4.2.1.49", "activity": "4-imidazolone-5-propanoate = trans-urocanate + H2O.", "evidence": [ { "id": "A0A3Q1LXH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8" } ] }, { "ec_number": "4.2.1.49", "activity": "", "evidence": [ { "id": "A0A3Q1LXH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LXH8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 764, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LXH8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LXH8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LXH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8" }, { "id": "PF17392", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17392" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Urocanase C-terminal", "eco_id": "ECO_0000259", "start_pos": 440, "end_pos": 634, "start_aa": "Asp", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LXH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8" }, { "id": "PF17391", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17391" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Urocanase N-terminal", "eco_id": "ECO_0000259", "start_pos": 85, "end_pos": 211, "start_aa": "Met", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LXH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXH8" }, { "id": "PF01175", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01175" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Urocanase Rossmann-like", "eco_id": "ECO_0000259", "start_pos": 214, "end_pos": 437, "start_aa": "Gly", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.2.1.49", "ec_name": "4-imidazolone-5-propanoate = trans-urocanate + H2O.", "evidence": [ { "id": "4.2.1.49", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.49" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 481 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 184, "end_pos": 186 }, { "start_pos": 424, "end_pos": 426 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": 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"field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LV37-1", "uniprot_ac": "A0A3Q1LV37", "uniprot_id": "A0A3Q1LV37_BOVIN", "mass": { "chemical_mass": 34681.0, "monoisotopic_mass": 34681.0 }, "refseq": { "ac": "NP_001376826", "name": "olfactory receptor family 4 subfamily L member 18", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376826" }, "gene_names": [ { "name": "OR4L18", "type": "recommended", "evidence": [ { "id": "A0A3Q1LV37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV37" } ] }, { "name": "OR4L18", "type": "synonym", "evidence": [ { "id": "NP_001376826", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376826" } ] }, { "name": "OR4L1", "type": "synonym", "evidence": [ { "id": "NP_001376826", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376826" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0A3Q1LV37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV37/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 4 subfamily L member 18", "type": "synonym", "evidence": [ { "id": "NP_001376826", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376826" } ] }, { "name": "olfactory receptor, family 4, subfamily L, member 1", "type": "synonym", "evidence": [ { "id": "NP_001376826", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376826" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376826" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV37", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV37#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV37", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV37" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4L18", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV37", "locus": { "chromosome": "10", "start_pos": 27478666, "end_pos": 27477737, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000055647", "url": "https://www.ensembl.org/id/ENSBTAG00000055647" } ] } } ], "crossref": [ { "id": "A0A3Q1LV37", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LV37", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050433", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050433", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15226", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15226", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512103", "url": "https://www.ncbi.nlm.nih.gov/gene/512103", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512103", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512103", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CIFICAW", "url": "https://omabrowser.org/oma/group/CIFICAW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LV37", "url": "https://www.orthodb.org/?gene=A0A3Q1LV37", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376826", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV37", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV37-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV37-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLKNGSVVTEFILQGFSVAWKLQIVFFVTFSLIYGATVLGNVLIMVTVTCSSTLHSPMYFLLGNLSFLDMCLSTVTTPKMIRDLLTEHKTISIWGCMAQMFFMHLFGGAEATLLVAMAFDRYVAVCKPLHYRKIMNHRLLNWSVILSWTIGFTHTMSQMVLTVNLPFCGPHIINNIFCDLPLVIKLACVETYTLELFVIADSGLLSLICFLLLLVSYTVILATVQRRSSGGLSKALSTLCAHITVVSLFFGPCIFIYAWPFKSFASNKVLAVFYTVITPLLNPIIYTLRNQKMQVAMRKLQFQNVSST", "length": 309, "header": "tr|A0A3Q1LV37-1|A0A3Q1LV37_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4L18 PE=3 SV=1 CANONICAL=A0A3Q1LV37-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LV37-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV37/entry", "sequence": { "sequence": "MDLKNGSVVTEFILQGFSVAWKLQIVFFVTFSLIYGATVLGNVLIMVTVTCSSTLHSPMYFLLGNLSFLDMCLSTVTTPKMIRDLLTEHKTISIWGCMAQMFFMHLFGGAEATLLVAMAFDRYVAVCKPLHYRKIMNHRLLNWSVILSWTIGFTHTMSQMVLTVNLPFCGPHIINNIFCDLPLVIKLACVETYTLELFVIADSGLLSLICFLLLLVSYTVILATVQRRSSGGLSKALSTLCAHITVVSLFFGPCIFIYAWPFKSFASNKVLAVFYTVITPLLNPIIYTLRNQKMQVAMRKLQFQNVSST", "length": 309, "header": "tr|A0A3Q1LV37-1|A0A3Q1LV37_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR4L18 PE=3 SV=1 CANONICAL=A0A3Q1LV37-1" }, "locus": { "chromosome": "10", "start_pos": 27478663, "end_pos": 27477737, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070597.1", "url": "https://www.ensembl.org/id/ENSBTAT00000070597.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059126.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059126.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512103", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512103", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S7L0-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDLKNGSVVTKFILLGFSVGWELQFVFLVTFSLIYGATVLGNVIMLTVTFSSTLHSPMYFLLGNLSFLDMCLSTVTTPKMIRDLLTKHKVISMWGCMAQMFFTHCFGGAEATLLIAMAFDRYVAICKPLHYRTIMSHKLLKGFVILSWTIGFIHTMSQMVLTVNLPFCGPHIIDNIFCDLPLVIKLACMDTYTLELFVIADSGLLSFICFLLLLVSYTVILVTVQQRSSGGLSKALSTLSAHITVVTLFFGPCIFIYAWPFSSFAGNKIFSVFYTVITPLLNPIIYTLRNEKMQEAMRK", "length": 299 }, "evidence": [ { "id": "A0A3Q1LV37", "url": "https://omabrowser.org/oma/group/A0A3Q1LV37/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3ID38-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100754555", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDYENGSAVTEFILVGFSGDWQLQTFLFVTFSLIYGATVVGNILIIVTVAANSTLRSPMYFLLGNLSFLDMGLSTVTTPKMIRDLLAELKSISVWGCMAQMFFMHFFGGAEMTLLIVMAFDRYVAICKPLHYRIIMSQRLLNMFVILSWTIGFIHTMSQMVLTVNLPFCGHNIVNSIFCDLPLVIKLACIETNTLELFVIADSGLLSFICFILLLVSYTVILVTVKHKSPGRLSKALSTLSAHIIVVTLFFGPCIFIYAYPFGSFASNKTFAVFYTVITPLLNPIIYTLRNQEMQKAMRKLWIKQVNFV", "length": 309 }, "evidence": [ { "id": "A0A3Q1LV37", "url": "https://omabrowser.org/oma/group/A0A3Q1LV37/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "K7N5X7-1", "protein_name": "Olfactory receptor", "gene_name": "Or4l15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDYKNGSAVTEFILVGFSGNWQLQIFFFVTFTLIYGATVVGNILIIVTVAANSALHSPMYFLLGNLSFLDMCLSTVTTPKMISDLLAAHKSISFQGCMVQMFFSHFLGGAEMTLLIVMAFDRYVAICKPLHYRIIMSHRLLNRFIILSWTIGFIHTMSQMALTVNLPFCGHNIINNIFCDLPLVIKLACIETYTLELFVIADSGLLSFISFFLLLVSYTVILLIVKHKSPGSLSKALSTLSAHIIVVTLFFGPCIFIYAWPFGSFASNTTLAVFYTVITPLLNPIIYTLRNQEMKKAMRKLWNQQVSCR", "length": 309 }, "evidence": [ { "id": "A0A3Q1LV37", "url": "https://omabrowser.org/oma/group/A0A3Q1LV37/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV37", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV37" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV37", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV37" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV37", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV37" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV37", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV37" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LV37-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 309, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LV37-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LV37" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LV37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV37" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 287, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 }, { "start_pos": 305, "end_pos": 307 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LV41-1", "uniprot_ac": "A0A3Q1LV41", "uniprot_id": "A0A3Q1LV41_BOVIN", "mass": { "chemical_mass": 35753.0, "monoisotopic_mass": 35753.0 }, "refseq": { "ac": "NP_001376695", "name": "olfactory receptor family 52 subfamily A member 1F", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376695" }, "gene_names": [ { "name": "OR52A1F", "type": "recommended", "evidence": [ { "id": "A0A3Q1LV41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV41" } ] }, { "name": "OR52A1F", "type": "synonym", "evidence": [ { "id": "NP_001376695", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376695" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0A3Q1LV41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV41/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 52 subfamily A member 1F", "type": "synonym", "evidence": [ { "id": "NP_001376695", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376695" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV41", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV41#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376695" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV41", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV41#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV41", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV41" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR52A1F", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV41", "locus": { "chromosome": "15", "start_pos": 48581789, "end_pos": 48582739, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065073", "url": "https://www.ensembl.org/id/ENSBTAG00000065073" } ] } } ], "crossref": [ { "id": "A0A3Q1LV41", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LV41", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050576", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050576", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505646", "url": "https://www.ncbi.nlm.nih.gov/gene/505646", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505646", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505646", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CNITIFQ", "url": "https://omabrowser.org/oma/group/CNITIFQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LV41", "url": "https://www.orthodb.org/?gene=A0A3Q1LV41", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF98", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF98", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376695", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV41", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV41-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV41-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSISNVTIFMPSVLTLIGIPGLESVQCWIGILFCAMYLIAMIGNSLLLIIIISEHSLHQPMYIFLGMLGVTDIALSTSIVPKMLGIFWFHVTEIYFDSCLLQMWLIHTFQCTESGILLAMALDRYVAICYPLRHAAVFSHQLVTQIAAMVTLRAAVLVTPCLILIKFRLQFYHTTVISHSYCEHMAVVKLAAENIRVNKICGLFVAFTVAGLDIVLITLSYIQIFITVFRLPQKEARLKAFNTCVAHICVFLQFYSLGFFSFFAHRFGSHIPPYIHILFSSTYLLVPPFLNPLVYGAKTKQIRVHMIKIFCSKNLL", "length": 316, "header": "tr|A0A3Q1LV41-1|A0A3Q1LV41_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 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"database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20173", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20173", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005221175", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221175", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV49-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC10", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC10-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHN4", "url": "https://www.uniprot.org/uniprotkb/E1BHN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BHN4-1", "url": "https://www.uniprot.org/uniprotkb/E1BHN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0D1", "url": "https://www.uniprot.org/uniprotkb/G3N0D1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0D1-1", "url": "https://www.uniprot.org/uniprotkb/G3N0D1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPAPGIPLPGSMECPSCRHISKEEAPKFCSECGQRLLPAAPEGVAGPQSNLKETSVPEVEMECGQELREESSPSLALGSGDWQESPDEPCSNASWQTKRGVVSKGFVDAADGTSTSDELEADSYSAYKRRKEDAILFEVTDTCSPESEQRRRRSKRKKRNSKNASTSAELDSLSPSSLEPCSLSSLANSGLQDTASCQSPAQQGSPTHQPGLPPSVDKIPLEAMGHPLQGEAAGEAEAAIGTESLSSLAPQDQTLGGALPEGNDHQSPSPSTGEDLPTSASEGSPREKDTAQELLFPEPKADTSKPRKELQTTEQLARAPASGASAAAAEPAGSVERAKKDVKDKTEEMKEPPTSVPASRNHRQEIATKDQMADPGGKTNENEKAKPKNLKSPEGNNGNNAAPVKNEKEQRNQSTQRAKESPLSSTEGIMVYFHAIISKHFGFNPDQHKVYVRGGKELGKPAWNHDVCEMHYSKDLHENGSLIEGSTTISKQHVDKPIPYKYVICRGKNSVEYEFIYKEQPKKGEHVNRCLRVKSSLLDSGDWHQYDDIICMRPPGTLQKWINHITDGTRKELVKGKQFSAAVMLDRIFSILETWNAINLKNFFTQFQQFYNVIRVPMIYEGEEQPWIALQYEEKKVRKHLWECLTKKMAPFLKTGGDPLPEDCPVKSKLRMGMIVLLLVEKFNFFLLEKDLASLCHLLHSDATSPDAFCRDLKHILETSQSWRQSLVNLCQMCMDKKVDFWVCALPVLHHCMDLSPPAQGSVMQPEDTWAALEGISFSEFRETRPDQNQLLQLMEKNRYLLNVDKYLFRSWFSLLPLSNLTPYMEHLIDYLSQCPPRVLDCLLGTWYRLHGLQEISQRNLESIENTFKMLLYLLDIYQEKILEEPLIQSYLTVCLKLHETTCRISKAHTFYEMPALSAEIVRRIIILKPVVDSAAGLGNETGKKNSVKTVFQGTLAATKSWLRKMFTMSIFQTGSSVTFTYSKEIEVWRRLVEINFPVEYDWKESLLGDMAGRLKQEMPLSRILAFCSSHWVAAGAEDSVAKCFEMCAIEAVGSVCQSQTSILGKISYNDLQKCGNLVSAVITKSWPTSRGEFVEDMGGVLNHLLTWPDIKHLFKLYGTNKEILANITKEGKKLMATAGSVFTEVTNDLISGTILVGHLELILEHMDRFLDIWQLKSKSSLAQDKKHPMEKVLNLRKIELFTLKKERTNVDSLLKLCGRVKDVIKVDFGEIAERHSEDLSGKKLNQVVTVTLSATPVDSKWTTHYNLSPEVQEMAKNAYLLKDSHIFQIFWEEAAQELSEPEENLESEIFQPEDVYECLYCPCFKRFTKLYQDLKSGEVTFGEIDDIFKDFVNKYSDLTEDLQTMSALYPREQKDWIKERVQQIKEYHHLHQAVDSAKVILEVKENLGLTGDFSVLHTLLSFTVLDNFRHKKLDRINQQIVRAKKLLQDIDETRCQCLKELSRRKEFISWVQEALRGITELKVFVDLASISAGENDIDVDRVACFHDAVQGYAPLLYELDTSAGFDEFMQHLKDLWKALDNDHNLPTKLHDSARNLEWLKTVKESHGSVELSSLSLATAINSRGIYVIKAPTDGQKISPDTVLHLILPEGQGGHEEKRDYSLEELKELLNKLMLMSGKKEHSNAEVVEVFSEVFCNVQRLVQSFINLYSAGNMLFRAWSAEVYCTPLKGASIQLDFCLGLMRPLVEGGPVVQLLEALCRQLEDFLGRWERFVAEKRAEHFYLNYYTAEQLVYLGLELGRETPSDAALTMLSFIKGNCTPRDVSEACRGPSGRANTHQERTVVEDLPLLPFSESRLVDKLRVIMKCSMTCMRVFLPHCLDLEALGHCLAHLARMAGPPVQRELSHGLQEGQPNLIVCGHSEVLPAALAIYMQTPHQPLPTYDEVLICTPETTFEEVALLLRRCLTPGSQGLGVYSLLYADQLSYEVACRAEALFRRLCTQPHREHYRLVMVCDCEREHCYLPSAFSQHKVLVTPQAPLKDIQAYLAHHFRVPEETPSAASVFQDRMCVGIVASERAGVGRSLFVKRLHGQLRMQFNGAKVPLKVIRLIDPQVDENEVLRSLLPFLDAPYQRRPIIFHFDMTSSVRTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIIEILEGNSTLPRRPSKLNALVPQFSFLDVFPKVTCRSPKEVINMELDPQQSYKEPGMDQREFCSEIFQRPYQYLRRFHQKKNLDTFQYQKGSVEGSPGECIQHLLIYCGVINPSWSELQNFARFLNYQLRDCEASLFCDPTFVGDTLMGFKNFVVTFMIFMARDFATPTLHTSDQSPGKYTFTMDGVKEEDLAPFTLRKRWESEPHPYVFFNSDHTSMTFIGFHFQSNQNGGVDAIDHLSGKVIKKDVMTVQLYQGLLLQRVPFNIDFDQLPRHEKIEKLCLALGIQWATDPDETYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGGADAETMKLVKVHGGTTADMIYSKVREAEELARFNKAQYQLDTILFFDEANTTEAISCIKEVLCDHTVGGQPLAKNSGLHIIAACNPYRKHTQEMICRLESAGLGYRVSAEETAERLGSIPLRQLVYRVHALPPSLIPLVWDFGQLNDSAEKLYIHQIVQRLVKSIKVVQSETHVITEVLSASQGFMRERQNECSFVSLRDVERCVKVFKWFYDHSEMLLSKLDSFLSETEVIQNDFERDPVLWSLVLAIGVCYHASLEKKESYRKAICKFFPAPYNDSRVILDEITRTQDLFLNGVSLRKTIARNLALKENVFMMVICIELKIPLFLVGKPGSSKSLAKTIVADAMQGQAARSDLFRHLKEVHLVSFQCSPHSTPQGIIGTFKQCARFQQGKDLEQYVSVVVLDEVGLAEDSPKMPLKALHPLLEDGCIEDDPAPHKKVGFIGISNWALDPAKMNRGIFVSRGSPDKGELIESARGICASDRLVQARIQGYFTSFAKAYETVCRRQDKEFFGLRDYYSLIKMVFAAAKASNKEPSPQDIAQAVLRNFSGKDDIHALDIFSANLPEAKYTEEVSTMQLIHQNIYGHLQKMHGRELDDSESRYLLVLTRNYVALRILQQKFFITDQPEIIFGSSFPKDQEYTQICRNINRVKICMETGKMVVLLNLQNLYESLYDALNQYYVYLGGQKYVDLGLGTHRVKCRVHSDFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEEWQKNIVEELKVWVEKFIDVKAEQFLARPKYSPSDVFIGYHSDTCASVVLQVLEQLGHEALTDELYQKVSEQAKSVLLDCATPDAVVRLNASSLGQFTAQSLSEEYYYKQHHNSFADFLQAHLCTMDSERHAIFTEITTFSRLLTSHDCELLESEVKDWAVKLTILSLQQFDTECSFLKEVRNCLAHTASCKILVIQTDFEDGSQSAQLIASAKYSAINEINKIQGDKNYILVYFITKLSRMGSGTSYVGFHGGLWHSVHIDDLRRSTVMVSDITKLQDVAISQLFKPEDAPKVEVGRRAQEDGEEAMETEAVTSQQVADVEMETESPEKNTSPTSGPEHDMQILDTTRLLRSCIQGAVGMLRDQNEGCQRSVRRVSILLRLLDEDATFLLVAKMRLYVLLMKQEENAICNVKDWVVREASNQDALQEAGTFRQTLWKRVQGAVTPLLASVISCVDRDGNLELLVSPHSPSWARDLWMFIFRDVKLLNIPLVTIDTRSKGEMSYIVVQNYMNLPEKASNSVPFSWRIKDYLEELWVHTQYITGDAGLAEKLLELFQKTPLGSFLAQLTVDQRQELLQCYLKDFLLLTMRVSTWEQLNVLQMALWSCINQLNAGRPEEEVSLPLVHLAYHRFRSRLQNFSRILTIHPPILLSLTKGTQNHTWAGREMSLDVLAAVACAEMLTENLLKPSPQAWLQTVKNLSMPLELLCSEGYMQDCGMMTRTLIRDIRTHWNRIFSISLFVEHVLLETESQIPELRKLVTNYVSLLNKCLLENSDMKTHRPFMAVMTTLRECKDQVSESFTRFGVQPCPICLGDAQDPVCLPCDHVFCLRCIEVNLRLGHMGCPLCLTDLPDGYSPTVSQEHREVIEKHARFRQMCNSFFVDLVSTMCFKDNSPPQKEVVKDLLSLLFVEKELLREAPQRRREHTKSLSPFDDVVDKTPVIRSVVLKLLLKYSFCDVKEYIQIYLSELEKKPFLAEDKTELYMLFSNCLEDSIHEKNNALFIRDEFKYLREEGQFLRTYQPVGCSRWLAGEASVEHLQKMARIRLCLDKASEILAELQDGSEVAEEKHRYLQQVERFCARVQNDWYRVYLVRKLTSQQGMEFVQSLSKEGHPAHWVFPKEVIAQQRDHPGQMDRYLVHGNDYKVVRDAVGKAILESKPLAVEAALEACRSATSQEAVYLLLALFREVATLYRSHNVDLHPKPQQCEAMKKFIEKSNTLSPDISAFAISLVNNELPLLRTGPGVSNLEGTVIEMAVHAATVLLCGQSQVLGPLKNLAFFPHLMVNAFLPTMPEDLLAQARNWKGLEGVTWYTCPNGHVCSVGECGKPMQQSFCIDCRAPIGGINHLPKEGFRVIKDTMDRTQTGHVLGNPPPRGAPVVSDRQMSPVVFLLIRLLTHLAMLLGATQSPQDLMNIIKPLVWDPKGFLQQHIQRDLEQLMNTLGRSADETASVVHLVLCRLLREQGHRSLNFDAQLSTRIQRNSWENLVQTLILRELEHLDKTLLAVNAQISQDERISSNPVAKIVYGDPVTFLPHLPKNSMVHCSKMWSCRKRITIEYLQHIVEQKNGKESVPILWKFLQKEAELRLVKFLPEILALQRNLVKRFQNVSEAEYRSIQSFISSHDSDGLKKLTRSRITIFLSTWNKLRRSLETNGEIKLPKDYCSSDLDLDTDLEVILPRRKGRGLCSTALVSYLIKLHNEIVYAVEKFSREDNSYSVDASEIADLHVISYEVERDLIPLILSNCQYQVEQGGETLQEFDLEKIQRQIISRFLQGKPRLTLKGLPTLVYRRDWNYEHLFMDIKNKMPQSPLPNSAITALRGQLQSYSDACEALSAIEVTLGFLSTAGGDPDMHLNVYIQDMLKMGDLTSLVSKALNRCKLKHTIALWQFLSAYKSEQLLRLGKKPFGEIDSRYKADLSPENAKLLNTFLNQIGLDAFLLELHEMMILKLKNPKIAESFNPEWSLRDTLVSYMETKDSEIPPEMESQFPEEILLSNCVAVWKMAAELKRNRQMR", "length": 5229, "header": "tr|A0A3Q1LV49-1|A0A3Q1LV49_BOVIN Isoform 1 of E3 ubiquitin-protein ligase RNF213 OS=Bos taurus OX=9913 GN=LOC512869 PE=3 SV=2 CANONICAL=A0A3Q1LV49-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LV49-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49/entry", "sequence": { "sequence": "MPAPGIPLPGSMECPSCRHISKEEAPKFCSECGQRLLPAAPEGVAGPQSNLKETSVPEVEMECGQELREESSPSLALGSGDWQESPDEPCSNASWQTKRGVVSKGFVDAADGTSTSDELEADSYSAYKRRKEDAILFEVTDTCSPESEQRRRRSKRKKRNSKNASTSAELDSLSPSSLEPCSLSSLANSGLQDTASCQSPAQQGSPTHQPGLPPSVDKIPLEAMGHPLQGEAAGEAEAAIGTESLSSLAPQDQTLGGALPEGNDHQSPSPSTGEDLPTSASEGSPREKDTAQELLFPEPKADTSKPRKELQTTEQLARAPASGASAAAAEPAGSVERAKKDVKDKTEEMKEPPTSVPASRNHRQEIATKDQMADPGGKTNENEKAKPKNLKSPEGNNGNNAAPVKNEKEQRNQSTQRAKESPLSSTEGIMVYFHAIISKHFGFNPDQHKVYVRGGKELGKPAWNHDVCEMHYSKDLHENGSLIEGSTTISKQHVDKPIPYKYVICRGKNSVEYEFIYKEQPKKGEHVNRCLRVKSSLLDSGDWHQYDDIICMRPPGTLQKWINHITDGTRKELVKGKQFSAAVMLDRIFSILETWNAINLKNFFTQFQQFYNVIRVPMIYEGEEQPWIALQYEEKKVRKHLWECLTKKMAPFLKTGGDPLPEDCPVKSKLRMGMIVLLLVEKFNFFLLEKDLASLCHLLHSDATSPDAFCRDLKHILETSQSWRQSLVNLCQMCMDKKVDFWVCALPVLHHCMDLSPPAQGSVMQPEDTWAALEGISFSEFRETRPDQNQLLQLMEKNRYLLNVDKYLFRSWFSLLPLSNLTPYMEHLIDYLSQCPPRVLDCLLGTWYRLHGLQEISQRNLESIENTFKMLLYLLDIYQEKILEEPLIQSYLTVCLKLHETTCRISKAHTFYEMPALSAEIVRRIIILKPVVDSAAGLGNETGKKNSVKTVFQGTLAATKSWLRKMFTMSIFQTGSSVTFTYSKEIEVWRRLVEINFPVEYDWKESLLGDMAGRLKQEMPLSRILAFCSSHWVAAGAEDSVAKCFEMCAIEAVGSVCQSQTSILGKISYNDLQKCGNLVSAVITKSWPTSRGEFVEDMGGVLNHLLTWPDIKHLFKLYGTNKEILANITKEGKKLMATAGSVFTEVTNDLISGTILVGHLELILEHMDRFLDIWQLKSKSSLAQDKKHPMEKVLNLRKIELFTLKKERTNVDSLLKLCGRVKDVIKVDFGEIAERHSEDLSGKKLNQVVTVTLSATPVDSKWTTHYNLSPEVQEMAKNAYLLKDSHIFQIFWEEAAQELSEPEENLESEIFQPEDVYECLYCPCFKRFTKLYQDLKSGEVTFGEIDDIFKDFVNKYSDLTEDLQTMSALYPREQKDWIKERVQQIKEYHHLHQAVDSAKVILEVKENLGLTGDFSVLHTLLSFTVLDNFRHKKLDRINQQIVRAKKLLQDIDETRCQCLKELSRRKEFISWVQEALRGITELKVFVDLASISAGENDIDVDRVACFHDAVQGYAPLLYELDTSAGFDEFMQHLKDLWKALDNDHNLPTKLHDSARNLEWLKTVKESHGSVELSSLSLATAINSRGIYVIKAPTDGQKISPDTVLHLILPEGQGGHEEKRDYSLEELKELLNKLMLMSGKKEHSNAEVVEVFSEVFCNVQRLVQSFINLYSAGNMLFRAWSAEVYCTPLKGASIQLDFCLGLMRPLVEGGPVVQLLEALCRQLEDFLGRWERFVAEKRAEHFYLNYYTAEQLVYLGLELGRETPSDAALTMLSFIKGNCTPRDVSEACRGPSGRANTHQERTVVEDLPLLPFSESRLVDKLRVIMKCSMTCMRVFLPHCLDLEALGHCLAHLARMAGPPVQRELSHGLQEGQPNLIVCGHSEVLPAALAIYMQTPHQPLPTYDEVLICTPETTFEEVALLLRRCLTPGSQGLGVYSLLYADQLSYEVACRAEALFRRLCTQPHREHYRLVMVCDCEREHCYLPSAFSQHKVLVTPQAPLKDIQAYLAHHFRVPEETPSAASVFQDRMCVGIVASERAGVGRSLFVKRLHGQLRMQFNGAKVPLKVIRLIDPQVDENEVLRSLLPFLDAPYQRRPIIFHFDMTSSVRTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIIEILEGNSTLPRRPSKLNALVPQFSFLDVFPKVTCRSPKEVINMELDPQQSYKEPGMDQREFCSEIFQRPYQYLRRFHQKKNLDTFQYQKGSVEGSPGECIQHLLIYCGVINPSWSELQNFARFLNYQLRDCEASLFCDPTFVGDTLMGFKNFVVTFMIFMARDFATPTLHTSDQSPGKYTFTMDGVKEEDLAPFTLRKRWESEPHPYVFFNSDHTSMTFIGFHFQSNQNGGVDAIDHLSGKVIKKDVMTVQLYQGLLLQRVPFNIDFDQLPRHEKIEKLCLALGIQWATDPDETYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGGADAETMKLVKVHGGTTADMIYSKVREAEELARFNKAQYQLDTILFFDEANTTEAISCIKEVLCDHTVGGQPLAKNSGLHIIAACNPYRKHTQEMICRLESAGLGYRVSAEETAERLGSIPLRQLVYRVHALPPSLIPLVWDFGQLNDSAEKLYIHQIVQRLVKSIKVVQSETHVITEVLSASQGFMRERQNECSFVSLRDVERCVKVFKWFYDHSEMLLSKLDSFLSETEVIQNDFERDPVLWSLVLAIGVCYHASLEKKESYRKAICKFFPAPYNDSRVILDEITRTQDLFLNGVSLRKTIARNLALKENVFMMVICIELKIPLFLVGKPGSSKSLAKTIVADAMQGQAARSDLFRHLKEVHLVSFQCSPHSTPQGIIGTFKQCARFQQGKDLEQYVSVVVLDEVGLAEDSPKMPLKALHPLLEDGCIEDDPAPHKKVGFIGISNWALDPAKMNRGIFVSRGSPDKGELIESARGICASDRLVQARIQGYFTSFAKAYETVCRRQDKEFFGLRDYYSLIKMVFAAAKASNKEPSPQDIAQAVLRNFSGKDDIHALDIFSANLPEAKYTEEVSTMQLIHQNIYGHLQKMHGRELDDSESRYLLVLTRNYVALRILQQKFFITDQPEIIFGSSFPKDQEYTQICRNINRVKICMETGKMVVLLNLQNLYESLYDALNQYYVYLGGQKYVDLGLGTHRVKCRVHSDFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEEWQKNIVEELKVWVEKFIDVKAEQFLARPKYSPSDVFIGYHSDTCASVVLQVLEQLGHEALTDELYQKVSEQAKSVLLDCATPDAVVRLNASSLGQFTAQSLSEEYYYKQHHNSFADFLQAHLCTMDSERHAIFTEITTFSRLLTSHDCELLESEVKDWAVKLTILSLQQFDTECSFLKEVRNCLAHTASCKILVIQTDFEDGSQSAQLIASAKYSAINEINKIQGDKNYILVYFITKLSRMGSGTSYVGFHGGLWHSVHIDDLRRSTVMVSDITKLQDVAISQLFKPEDAPKVEVGRRAQEDGEEAMETEAVTSQQVADVEMETESPEKNTSPTSGPEHDMQILDTTRLLRSCIQGAVGMLRDQNEGCQRSVRRVSILLRLLDEDATFLLVAKMRLYVLLMKQEENAICNVKDWVVREASNQDALQEAGTFRQTLWKRVQGAVTPLLASVISCVDRDGNLELLVSPHSPSWARDLWMFIFRDVKLLNIPLVTIDTRSKGEMSYIVVQNYMNLPEKASNSVPFSWRIKDYLEELWVHTQYITGDAGLAEKLLELFQKTPLGSFLAQLTVDQRQELLQCYLKDFLLLTMRVSTWEQLNVLQMALWSCINQLNAGRPEEEVSLPLVHLAYHRFRSRLQNFSRILTIHPPILLSLTKGTQNHTWAGREMSLDVLAAVACAEMLTENLLKPSPQAWLQTVKNLSMPLELLCSEGYMQDCGMMTRTLIRDIRTHWNRIFSISLFVEHVLLETESQIPELRKLVTNYVSLLNKCLLENSDMKTHRPFMAVMTTLRECKDQVSESFTRFGVQPCPICLGDAQDPVCLPCDHVFCLRCIEVNLRLGHMGCPLCLTDLPDGYSPTVSQEHREVIEKHARFRQMCNSFFVDLVSTMCFKDNSPPQKEVVKDLLSLLFVEKELLREAPQRRREHTKSLSPFDDVVDKTPVIRSVVLKLLLKYSFCDVKEYIQIYLSELEKKPFLAEDKTELYMLFSNCLEDSIHEKNNALFIRDEFKYLREEGQFLRTYQPVGCSRWLAGEASVEHLQKMARIRLCLDKASEILAELQDGSEVAEEKHRYLQQVERFCARVQNDWYRVYLVRKLTSQQGMEFVQSLSKEGHPAHWVFPKEVIAQQRDHPGQMDRYLVHGNDYKVVRDAVGKAILESKPLAVEAALEACRSATSQEAVYLLLALFREVATLYRSHNVDLHPKPQQCEAMKKFIEKSNTLSPDISAFAISLVNNELPLLRTGPGVSNLEGTVIEMAVHAATVLLCGQSQVLGPLKNLAFFPHLMVNAFLPTMPEDLLAQARNWKGLEGVTWYTCPNGHVCSVGECGKPMQQSFCIDCRAPIGGINHLPKEGFRVIKDTMDRTQTGHVLGNPPPRGAPVVSDRQMSPVVFLLIRLLTHLAMLLGATQSPQDLMNIIKPLVWDPKGFLQQHIQRDLEQLMNTLGRSADETASVVHLVLCRLLREQGHRSLNFDAQLSTRIQRNSWENLVQTLILRELEHLDKTLLAVNAQISQDERISSNPVAKIVYGDPVTFLPHLPKNSMVHCSKMWSCRKRITIEYLQHIVEQKNGKESVPILWKFLQKEAELRLVKFLPEILALQRNLVKRFQNVSEAEYRSIQSFISSHDSDGLKKLTRSRITIFLSTWNKLRRSLETNGEIKLPKDYCSSDLDLDTDLEVILPRRKGRGLCSTALVSYLIKLHNEIVYAVEKFSREDNSYSVDASEIADLHVISYEVERDLIPLILSNCQYQVEQGGETLQEFDLEKIQRQIISRFLQGKPRLTLKGLPTLVYRRDWNYEHLFMDIKNKMPQSPLPNSAITALRGQLQSYSDACEALSAIEVTLGFLSTAGGDPDMHLNVYIQDMLKMGDLTSLVSKALNRCKLKHTIALWQFLSAYKSEQLLRLGKKPFGEIDSRYKADLSPENAKLLNTFLNQIGLDAFLLELHEMMILKLKNPKIAESFNPEWSLRDTLVSYMETKDSEIPPEMESQFPEEILLSNCVAVWKMAAELKRNRQMR", "length": 5229, "header": "tr|A0A3Q1LV49-1|A0A3Q1LV49_BOVIN Isoform 1 of E3 ubiquitin-protein ligase RNF213 OS=Bos taurus OX=9913 GN=LOC512869 PE=3 SV=2 CANONICAL=A0A3Q1LV49-1" }, "locus": { "chromosome": "19", "start_pos": 52239830, "end_pos": 52121873, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082004.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082004.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061068.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061068.2" } ] } }, { "isoform_ac": "A0A3Q1MC10-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC10/entry", "sequence": { "sequence": "MPAPGIPLPGSMECPSCRHISKEEAPKFCSECGQRLLPAAPEGVAGPQSNLKETSVPEVEMECGQELREESSPSLALGSGDWQESPDEPCSNASWQTKRRRRRSKRKKRNSKNASTSAELDSLSPSSLEPCSLSSLANSGLQDTASCQSPAQQGSPTHQPGLPPSVDKIPLEAMGHPLQGEAAGEAEAAIGTESLSSLAPQDQTLGGALPEGNDHQSPSPSTGEDLPTSASEGSPREKDTAQELLFPEPKADTSKPRKELQTTEQLARAPASGASAAAAEPAGSVERAKKDVKDKTEEMKEPPTSVPASRNHRQEIATKDQMADPGGKTNENEKAKPKNLKSPEGNNGNNAAPVKNEKEQRNQSTQRAKESPLSSTEGIMVYFHAIISKHFGFNPDQHKVYVRGGKELGKPAWNHDVCEMHYSKDLHENGSLIEGSTTISKQHVDKPIPYKYVICRGKNSVEYEFIYKEQPKKGEHVNRCLRVKSSLLDSGDWHQYDDIICMRPPGTLQKWINHITDGTRKELVKGKQFSAAVMLDRIFSILETWNAINLKNFFTQFQQFYNVIRVPMIYEGEEQPWIALQYEEKKVRKHLWECLTKKMAPFLKTGGDPLPEDCPVKSKLRMGMIVLLLVEKFNFFLLEKDLASLCHLLHSDATSPDAFCRDLKHILETSQSWRQSLVNLCQMCMDKKVDFWVCALPVLHHCMDLSPPAQGSVMQPEDTWAALEGISFSEFRETRPDQNQLLQLMEKNRYLLNVDKYLFRSWFSLLPLSNLTPYMEHLIDYLSQCPPRVLDCLLGTWYRLHGLQEISQRNLESIENTFKMLLYLLDIYQEKILEEPLIQSYLTVCLKLHETTCRISKAHTFYEMPALSAEIVRRIIILKPVVDSAAGLGNETGKKNSVKTVFQGTLAATKSWLRKMFTMSIFQTGSSVTFTYSKEIEVWRRLVEINFPVEYDWKESLLGDMAGRLKQEMPLSRILAFCSSHWVAAGAEDSVAKCFEMCAIEAVGSVCQSQTSILGKISYNDLQKCGNLVSAVITKSWPTSRGEFVEDMGGVLNHLLTWPDIKHLFKLYGTNKEILANITKEGKKLMATAGSVFTEVTNDLISGTILVGHLELILEHMDRFLDIWQLKSKSSLAQDKKHPMEKVLNLRKIELFTLKKERTNVDSLLKLCGRVKDVIKVDFGEIAERHSEDLSGKKLNQVVTVTLSATPVDSKWTTHYNLSPEVQEMAKNAYLLKDSHIFQIFWEEAAQELSEPEENLESEIFQPEDVYECLYCPCFKRFTKLYQDLKSGEVTFGEIDDIFKDFVNKYSDLTEDLQTMSALYPREQKDWIKERVQQIKEYHHLHQAVDSAKVILEVKENLGLTGDFSVLHTLLSFTVLDNFRHKKLDRINQQIVRAKKLLQDIDETRCQCLKELSRRKEFISWVQEALRGITELKVFVDLASISAGENDIDVDRVACFHDAVQGYAPLLYELDTSAGFDEFMQHLKDLWKALDNDHNLPTKLHDSARNLEWLKTVKESHGSVELSSLSLATAINSRGIYVIKAPTDGQKISPDTVLHLILPEGQGGHEEKRDYSLEELKELLNKLMLMSGKKEHSNAEVVEVFSEVFCNVQRLVQSFINLYSAGNMLFRAWSAEVYCTPLKGASIQLDFCLGLMRPLVEGGPVVQLLEALCRQLEDFLGRWERFVAEKRAEHFYLNYYTAEQLVYLGLELGRETPSDAALTMLSFIKGNCTPRDVSEACRGPSGRANTHQERTVVEDLPLLPFSESRLVDKLRVIMKCSMTCMRVFLPHCLDLEALGHCLAHLARMAGPPVQRELSHGLQEGQPNLIVCGHSEVLPAALAIYMQTPHQPLPTYDEVLICTPETTFEEVALLLRRCLTPGSQGLGVYSLLYADQLSYEVACRAEALFRRLCTQPHREHYRLVMVCDCEREHCYLPSAFSQHKVLVTPQAPLKDIQAYLAHHFRVPEETPSAASVFQDRMCVGIVASERAGVGRSLFVKRLHGQLRMQFNGAKVPLKVIRLIDPQVDENEVLRSLLPFLDAPYQRRPIIFHFDMTSSVRTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIIEILEGNSTLPRRPSKLNALVPQFSFLDVFPKVTCRSPKEVINMELDPQQSYKEPGMDQREFCSEIFQRPYQYLRRFHQKKNLDTFQYQKGSVEGSPGECIQHLLIYCGVINPSWSELQNFARFLNYQLRDCEASLFCDPTFVGDTLMGFKNFVVTFMIFMARDFATPTLHTSDQSPGKYTFTMDGVKEEDLAPFTLRKRWESEPHPYVFFNSDHTSMTFIGFHFQSNQNGGVDAIDHLSGKVIKKDVMTVQLYQGLLLQRVPFNIDFDQLPRHEKIEKLCLALGIQWATDPDETYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGGADAETMKLVKVHGGTTADMIYSKVREAEELARFNKAQYQLDTILFFDEANTTEAISCIKEVLCDHTVGGQPLAKNSGLHIIAACNPYRKHTQEMICRLESAGLGYRVSAEETAERLGSIPLRQLVYRVHALPPSLIPLVWDFGQLNDSAEKLYIHQIVQRLVKSIKVVQSETHVITEVLSASQGFMRERQNECSFVSLRDVERCVKVFKWFYDHSEMLLSKLDSFLSETEVIQNDFERDPVLWSLVLAIGVCYHASLEKKESYRKAICKFFPAPYNDSRVILDEITRTQDLFLNGVSLRKTIARNLALKENVFMMVICIELKIPLFLVGKPGSSKSLAKTIVADAMQGQAARSDLFRHLKEVHLVSFQCSPHSTPQGIIGTFKQCARFQQGKDLEQYVSVVVLDEVGLAEDSPKMPLKALHPLLEDGCIEDDPAPHKKVGFIGISNWALDPAKMNRGIFVSRGSPDKGELIESARGICASDRLVQARIQGYFTSFAKAYETVCRRQDKEFFGLRDYYSLIKMVFAAAKASNKEPSPQDIAQAVLRNFSGKDDIHALDIFSANLPEAKYTEEVSTMQLIHQNIYGHLQKMHGRELDDSESRYLLVLTRNYVALRILQQKFFITDQPEIIFGSSFPKDQEYTQICRNINRVKICMETGKMVVLLNLQNLYESLYDALNQYYVYLGGQKYVDLGLGTHRVKCRVHSDFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEEWQKNIVEELKVWVEKFIDVKAEQFLARPKYSPSDVFIGYHSDTCASVVLQVLEQLGHEALTDELYQKVSEQAKSVLLDCATPDAVVRLNASSLGQFTAQSLSEEYYYKQHHNSFADFLQAHLCTMDSERHAIFTEITTFSRLLTSHDCELLESEVKDWAVKLTILSLQQFDTECSFLKEVRNCLAHTASCKILVIQTDFEDGSQSAQLIASAKYSAINEINKIQGDKNYILVYFITKLSRMGSGTSYVGFHGGLWHSVHIDDLRRSTVMVSDITKLQDVAISQLFKPEDAPKVEVGRRAQEDGEEAMETEAVTSQQVADVEMETESPEKNTSPTSGPEHDMQILDTTRLLRSCIQGAVGMLRDQNEGCQRSVRRVSILLRLLDEDATFLLVAKMRLYVLLMKQEENAICNVKDWVVREASNQDALQEAGTFRQTLWKRVQGAVTPLLASVISCVDRDGNLELLVSPHSPSWARDLWMFIFRDVKLLNIPLVTIDTRSKGEMSYIVVQNYMNLPEKASNSVPFSWRIKDYLEELWVHTQYITGDAGLAEKLLELFQKTPLGSFLAQLTVDQRQELLQCYLKDFLLLTMRVSTWEQLNVLQMALWSCINQLNAGRPEEEVSLPLVHLAYHRFRSRLQNFSRILTIHPPILLSLTKGTQNHTWAGREMSLDVLAAVACAEMLTENLLKPSPQAWLQTVKNLSMPLELLCSEGYMQDCGMMTRTLIRDIRTHWNRIFSISLFVEHVLLETESQIPELRKLVTNYVSLLNKCLLENSDMKTHRPFMAVMTTLRECKDQVSESFTRFGVQPCPICLGDAQDPVCLPCDHVFCLRCIEVNLRLGHMGCPLCLTDLPDGYSPTVSQEHREVIEKHARFRQMCNSFFVDLVSTMCFKDNSPPQKEVVKDLLSLLFVEKELLREAPQRRREHTKSLSPFDDVVDKTPVIRSVVLKLLLKYSFCDVKEYIQIYLSELEKKPFLAEDKTELYMLFSNCLEDSIHEKNNALFIRDEFKYLREEGQFLRTYQPVGCSRWLAGEASVEHLQKMARIRLCLDKASEILAELQDGSEVAEEKHRYLQQVERFCARVQNDWYRVYLVRKLTSQQGMEFVQSLSKEGHPAHWVFPKEVIAQQRDHPGQMDRYLVHGNDYKVVRDAVGKAILESKPLAVEAALEACRSATSQEAVYLLLALFREVATLYRSHNVDLHPKPQQCEAMKKFIEKSNTLSPDISAFAISLVNNELPLLRTGPGVSNLEGTVIEMAVHAATVLLCGQSQVLGPLKNLAFFPHLMVNAFLPTMPEDLLAQARNWKGLEGVTWYTCPNGHVCSVGECGKPMQQSFCIDCRAPIGGINHLPKEGFRVIKDTMDRTQTGHVLGNPPPRGAPVVSDRQMSPVVFLLIRLLTHLAMLLGATQSPQDLMNIIKPLVWDPKGFLQQHIQRDLEQLMNTLGRSADETASVVHLVLCRLLREQGHRSLNFDAQLSTRIQRNSWENLVQTLILRELEHLDKTLLAVNAQISQDERISSNPVAKIVYGDPVTFLPHLPKNSMVHCSKMWSCRKRITIEYLQHIVEQKNGKESVPILWKFLQKEAELRLVKFLPEILALQRNLVKRFQNVSEAEYRSIQSFISSHDSDGLKKLTRSRITIFLSTWNKLRRSLETNGEIKLPKDYCSSDLDLDTDLEVILPRRKGRGLCSTALVSYLIKLHNEIVYAVEKFSREDNSYSVDASEIADLHVISYEVERDLIPLILSNCQYQVEQGGETLQEFDLEKIQRQIISRFLQGKPRLTLKGLPTLVYRRDWNYEHLFMDIKNKMPQSPLPNSAITALRGQLQSYSDACEALSAIEVTLGFLSTAGGDPDMHLNVYIQDMLKMGDLTSLVSKALNRCKLKHTIALWQFLSAYKSEQLLRLGKKPFGEIDSRYKADLSPENAKLLNTFLNQIGLDAFLLELHEMMILKLKNPKIAESFNPEWSLRDTLVSYMETKDSEIPPEMESQFPEEILLSNCVAVWKMAAELKRNRQMR", "length": 5179, "header": "tr|A0A3Q1MC10-1|A0A3Q1LV49_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase RNF213 OS=Bos taurus OX=9913 GN=LOC512869 PE=3 SV=2 CANONICAL=A0A3Q1LV49-1" }, "locus": { "chromosome": "19", "start_pos": 52239830, "end_pos": 52121873, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067476.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067476.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068318.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068318.2" } ] } }, { "isoform_ac": "E1BHN4-1", "url": "https://www.uniprot.org/uniprotkb/E1BHN4/entry", "sequence": { "sequence": "MPAPGIPLPGSMECPSCRHISKEEAPKFCSECGQRLLPAAPEGVAGPQSNLKETSVPEVEMECGQELREESSPSLALGSGDWQESPDEPCSNASWQTKRASAAAAEPAGSVERAKKDVKDKTEEMKEPPTSVPASRNHRQEIATKDQMADPGGKTNENEKAKPKNLKSPEGNNGNNAAPVKNEKEQRNQSTQRAKESPLSSTEGIMVYFHAIISKHFGFNPDQHKVYVRGGKELGKPAWNHDVCEMHYSKDLHENGSLIEGSTTISKQHVDKPIPYKYVICRGKNSVEYEFIYKEQPKKGEHVNRCLRVKSSLLDSGDWHQYDDIICMRPPGTLQKWINHITDGTRKELVKGKQFSAAVMLDRIFSILETWNAINLKNFFTQFQQFYNVIRVPMIYEGEEQPWIALQYEEKKVRKHLWECLTKKMAPFLKTGGDPLPEDCPVKSKLRMGMIVLLLVEKFNFFLLEKDLASLCHLLHSDATSPDAFCRDLKHILETSQSWRQSLVNLCQMCMDKKVDFWVCALPVLHHCMDLSPPAQGSVMQPEDTWAALEGISFSEFRETRPDQNQLLQLMEKNRYLLNVDKYLFRSWFSLLPLSNLTPYMEHLIDYLSQCPPRVLDCLLGTWYRLHGLQEISQRNLESIENTFKMLLYLLDIYQEKILEEPLIQSYLTVCLKLHETTCRISKAHTFYEMPALSAEIVRRIIILKPVVDSAAGLGNETGKKNSVKTVFQGTLAATKSWLRKMFTMSIFQTGSSVTFTYSKEIEVWRRLVEINFPVEYDWKESLLGDMAGRLKQEMPLSRILAFCSSHWVAAGAEDSVAKCFEMCAIEAVGSVCQSQTSILGKISYNDLQKCGNLVSAVITKSWPTSRGEFVEDMGGVLNHLLTWPDIKHLFKLYGTNKEILANITKEGKKLMATAGSVFTEVTNDLISGTILVGHLELILEHMDRFLDIWQLKSKSSLAQDKKHPMEKVLNLRKIELFTLKKERTNVDSLLKLCGRVKDVIKVDFGEIAERHSEDLSGKKLNQVVTVTLSATPVDSKWTTHYNLSPEVQEMAKNAYLLKDSHIFQIFWEEAAQELSEPEENLESEIFQPEDVYECLYCPCFKRFTKLYQDLKSGEVTFGEIDDIFKDFVNKYSDLTEDLQTMSALYPREQKDWIKERVQQIKEYHHLHQAVDSAKVILEVKENLGLTGDFSVLHTLLSFTVLDNFRHKKLDRINQQIVRAKKLLQDIDETRCQCLKELSRRKEFISWVQEALRGITELKVFVDLASISAGENDIDVDRVACFHDAVQGYAPLLYELDTSAGFDEFMQHLKDLWKALDNDHNLPTKLHDSARNLEWLKTVKESHGSVELSSLSLATAINSRGIYVIKAPTDGQKISPDTVLHLILPEGQGGHEEKRDYSLEELKELLNKLMLMSGKKEHSNAEVVEVFSEVFCNVQRLVQSFINLYSAGNMLFRAWSAEVYCTPLKGASIQLDFCLGLMRPLVEGGPVVQLLEALCRQLEDFLGRWERFVAEKRAEHFYLNYYTAEQLVYLGLELGRETPSDAALTMLSFIKGNCTPRDVSEACRGPSGRANTHQERTVVEDLPLLPFSESRLVDKLRVIMKCSMTCMRVFLPHCLDLEALGHCLAHLARMAGPPVQRELSHGLQEGQPNLIVCGHSEVLPAALAIYMQTPHQPLPTYDEVLICTPETTFEEVALLLRRCLTPGSQGLGVYSLLYADQLSYEVACRAEALFRRLCTQPHREHYRLVMVCDCEREHCYLPSAFSQHKVLVTPQAPLKDIQAYLAHHFRVPEETPSAASVFQDRMCVGIVASERAGVGRSLFVKRLHGQLRMQFNGAKVPLKVIRLIDPQVDENEVLRSLLPFLDAPYQRRPIIFHFDMTSSVRTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIIEILEGNSTLPRRPSKLNALVPQFSFLDVFPKVTCRSPKEVINMELDPQQSYKEPGMDQREFCSEIFQRPYQYLRRFHQKKNLDTFQYQKGSVEGSPGECIQHLLIYCGVINPSWSELQNFARFLNYQLRDCEASLFCDPTFVGDTLMGFKNFVVTFMIFMARDFATPTLHTSDQSPGKYTFTMDGVKEEDLAPFTLRKRWESEPHPYVFFNSDHTSMTFIGFHFQSNQNGGVDAIDHLSGKVIKKDVMTVQLYQGLLLQRVPFNIDFDQLPRHEKIEKLCLALGIQWATDPDETYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGGADAETMKLVKVHGGTTADMIYSKVREAEELARFNKAQYQLDTILFFDEANTTEAISCIKEVLCDHTVGGQPLAKNSGLHIIAACNPYRKHTQEMICRLESAGLGYRVSAEETAERLGSIPLRQLVYRVHALPPSLIPLVWDFGQLNDSAEKLYIHQIVQRLVKSIKVVQSETHVITEVLSASQGFMRERQNECSFVSLRDVERCVKVFKWFYDHSEMLLSKLDSFLSETEVIQNDFERDPVLWSLVLAIGVCYHASLEKKESYRKAICKFFPAPYNDSRVILDEITRTQDLFLNGVSLRKTIARNLALKENVFMMVICIELKIPLFLVGKPGSSKSLAKTIVADAMQGQAARSDLFRHLKEVHLVSFQCSPHSTPQGIIGTFKQCARFQQGKDLEQYVSVVVLDEVGLAEDSPKMPLKALHPLLEDGCIEDDPAPHKKVGFIGISNWALDPAKMNRGIFVSRGSPDKGELIESARGICASDRLVQARIQGYFTSFAKAYETVCRRQDKEFFGLRDYYSLIKMVFAAAKASNKEPSPQDIAQAVLRNFSGKDDIHALDIFSANLPEAKYTEEVSTMQLIHQNIYGHLQKMHGRELDDSESRYLLVLTRNYVALRILQQKFFITDQPEIIFGSSFPKDQEYTQICRNINRVKICMETGKMVVLLNLQNLYESLYDALNQYYVYLGGQKYVDLGLGTHRVKCRVHSDFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEEWQKNIVEELKVWVEKFIDVKAEQFLARPKYSPSDVFIGYHSDTCASVVLQVLEQLGHEALTDELYQKVSEQAKSVLLDCATPDAVVRLNASSLGQFTAQSLSEEYYYKQHHNSFADFLQAHLCTMDSERHAIFTEITTFSRLLTSHDCELLESEVKDWAVKLTILSLQQFDTECSFLKEVRNCLAHTASCKILVIQTDFEDGSQSAQLIASAKYSAINEINKIQGDKNYILVYFITKLSRMGSGTSYVGFHGGLWHSVHIDDLRRSTVMVSDITKLQDVAISQLFKPEDAPKVEVGRRAQEDGEEAMETEAVTSQQVADVEMETESPEKNTSPTSGPEHDMQILDTTRLLRSCIQGAVGMLRDQNEGCQRSVRRVSILLRLLDEDATFLLVAKMRLYVLLMKQEENAICNVKDWVVREASNQDALQEAGTFRQTLWKRVQGAVTPLLASVISCVDRDGNLELLVSPHSPSWARDLWMFIFRDVKLLNIPLVTIDTRSKGEMSYIVVQNYMNLPEKASNSVPFSWRIKDYLEELWVHTQYITGDAGLAEKLLELFQKTPLGSFLAQLTVDQRQELLQCYLKDFLLLTMRVSTWEQLNVLQMALWSCINQLNAGRPEEEVSLPLVHLAYHRFRSRLQNFSRILTIHPPILLSLTKGTQNHTWAGREMSLDVLAAVACAEMLTENLLKPSPQAWLQTVKNLSMPLELLCSEGYMQDCGMMTRTLIRDIRTHWNRIFSISLFVEHVLLETESQIPELRKLVTNYVSLLNKCLLENSDMKTHRPFMAVMTTLRECKDQVSESFTRFGVQPCPICLGDAQDPVCLPCDHVFCLRCIEVNLRLGHMGCPLCLTDLPDGYSPTVSQEHREVIEKHARFRQMCNSFFVDLVSTMCFKDNSPPQKEVVKDLLSLLFVEKELLREAPQRRREHTKSLSPFDDVVDKTPVIRSVVLKLLLKYSFCDVKEYIQIYLSELEKKPFLAEDKTELYMLFSNCLEDSIHEKNNALFIRDEFKYLREEGQFLRTYQPVGCSRWLAGEASVEHLQKMARIRLCLDKASEILAELQDGSEVAEEKHRYLQQVERFCARVQNDWYRVYLVRKLTSQQGMEFVQSLSKEGHPAHWVFPKEVIAQQRDHPGQMDRYLVHGNDYKVVRDAVGKAILESKPLAVEAALEACRSATSQEAVYLLLALFREVATLYRSHNVDLHPKPQQCEAMKKFIEKSNTLSPDISAFAISLVNNELPLLRTGPGVSNLEGTVIEMAVHAATVLLCGQSQVLGPLKNLAFFPHLMVNAFLPTMPEDLLAQARNWKGLEGVTWYTCPNGHVCSVGECGKPMQQSFCIDCRAPIGGINHLPKEGFRVIKDTMDRTQTGHVLGNPPPRGAPVVSDRQMSPVVFLLIRLLTHLAMLLGATQSPQDLMNIIKPLVWDPKGFLQQHIQRDLEQLMNTLGRSADETASVVHLVLCRLLREQGHRSLNFDAQLSTRIQRNSWENLVQTLILRELEHLDKTLLAVNAQISQDERISSNPVAKIVYGDPVTFLPHLPKNSMVHCSKMWSCRKRITIEYLQHIVEQKNGKESVPILWKFLQKEAELRLVKFLPEILALQRNLVKRFQNVSEAEYRSIQSFISSHDSDGLKKLTRSRITIFLSTWNKLRRSLETNGEIKLPKDYCSSDLDLDTDLEVILPRRKGRGLCSTALVSYLIKLHNEIVYAVEKFSREDNSYSVDASEIADLHVISYEVERDLIPLILSNCQYQVEQGGETLQEFDLEKIQRQIISRFLQGKPRLTLKGLPTLVYRRDWNYEHLFMDIKNKMPQSPLPNSAITALRGQLQSYSDACEALSAIEVTLGFLSTAGGDPDMHLNVYIQDMLKMGDLTSLVSKALNRCKLKHTIALWQFLSAYKSEQLLRLGKKPFGEIDSRYKADLSPENAKLLNTFLNQIGLDAFLLELHEMMILKLKNPKIAESFNPEWSLRDTLVSYMETKDSEIPPEMESQFPEEILLSNCVAVWKMAAELKRNRQMR", "length": 5005, "header": "tr|E1BHN4-1|A0A3Q1LV49_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase RNF213 OS=Bos taurus OX=9913 GN=LOC512869 PE=3 SV=4 CANONICAL=A0A3Q1LV49-1" }, "locus": { "chromosome": "19", "start_pos": 52239830, "end_pos": 52121873, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030444.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030444.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030425.6", "url": "https://www.ensembl.org/id/ENSBTAP00000030425.6" } ] } }, { "isoform_ac": "G3N0D1-1", "url": "https://www.uniprot.org/uniprotkb/G3N0D1/entry", "sequence": { "sequence": "MPDPGIPLPGGMECPSCRYIAKEEAPKLCSECGQRLLPTAPKRVPDSQSNLKEASALEGAKECGSELREESNSSLSPGSGDSQDDPDEPSLDTSWQTKQASDAAAESAVSVKGVGKDVKDKTEEMKEPPTSVPASRNHRQEIATKDQTALPGGKTGENEKAKPKDLKRPEGNNGNNAAPVKNEKEQRNQSTQRAKESLLSSMEGIMVYFHAIISKHFEFNPHQHKVFVRGGKEFGEPAWSHNVCEMHYSKDLHENGSLIEGSTTISKQHVDKPIPYKYIICKGKNSEEYEFIYTSQQKKGEYVNRCLRVKSSLLDSGDWHQYDDIICMKPPGTLKKLMNYITDGTRKDLMKGKQIAAAVMLDSIFSILETWNAINLKNFFTQFQQFYSVIHVPMTYEGEEQPWSALRYKEEVRKHLWECVTKKMAPFLETSGDPLPEDYPVKSKLGMGMIVLFLVEKFDFLLLENDLASLCHLLRLDTNSLGTFPKDLKDILETSQSWRVSLVNLCQMCMDKKVDFWVCALPVLHHCMDLSPPAQGSVTQPEDTWAALEGISFSEFRETRPDQKELLELMRKNRHLLNVDEFLFRSWFSLLPLSNLAPYMEHFIDYLSQSPPHVLDCLLGTWYRLKGLEKISNRNLQNIKNTFKMLLHLLDIYQEKILEEPLIQPYLIVCLKLHETTCRISKAHTFYEMPALSAEIVRRIIILKPLVDSAGGPGNETGKKNSVKTVFQGTLAATRSWLRKNFKKSMFQAGYFYFSPVTFAYSEEIEVWRRLVEIRFPVEHGWKESLLRDLEGRFKQEMPFFQICAFCNSNWDATGAEDSVAKCFEMCAIEAVGLVCQSQTSILEKISYNNSRKCDTIVSAVITKSWPRSGGEFVDNMGEVLNHLLIWPDIKHLFKLCGTNEKILANITKEGKKLMATADSVFTKVTSDLINGTILVGQLELIVKHMNQFFDLWHLKNKSLSAQAKEDILNLRKKELDTLEKEKTYVDSLLKLCGRVKDLIKVDFGEIAERYSEDLSGKKLNQVVTVSLSATSLDSTWATCYNLSPEVQEMARNAYLLKDSHIFPIFWAKAAQELSEPEENLERKIFQPEEVYEYLYCPCFKRFTKLYQDLKSGEVTFGEINDIFKDFVNKYSDLTEDLQIMSALDPRDQKDWIKERVQQIKEYHHLHQAVDSAKVILEVKENLGLTGDFSVLHTLLSFTDLDKICHEKLNRINQHIIHAKKLLQDVSETRCQCLKELSQRKEFIGWVREALRGITELKVFVDLASISAGENDIDVDRVACFHDAVQGYAPLLYELDTSAGFDEFVQHLKELWKALDNDHNLPTKLRDSARNLEWLKTVKESHGSVELSSLSLATAINSRGIYVIKAPTDGQKISPDTVLHLILPEGQEGHKEKRDYSLEELKELLNKLMLMSGKKEHSNAEVVEVFSEVFCNVQRLVQSFINLYSAGNMLFRAWSAEVYCTPLKGASIRLDFCLGLMGPLVEGGPVVQLLEALCRQLEDFLGRWERFVAEKRAEHFYLNYYTAEQLVYLGLELGRETPSDAALTMLSFIKGNCTPRDVSEACRGPSGRANTHQERTVVEDLPLLPFSESRLVDKLRVIMKCSMTCMRVFLPHCLDLEALGHCLAHLARMAGPPVQRELSHGLQEGQPNLIVCGHSEVLPATLAIYMQTPHQPLPTYDEVLLCTPETTFEEVALLLRRCLTPGSQGLGVYSLLYADQLSYEVACRAEALFRRLCTQPHREHYRLVMVCDCEREHCYLPSAFSQHKVLVTPQAPLKDIQAYLAHHFRVPEETPSAASVFQDHMCVGIVASERAGVGRSLFVKRLHGQLKMQFNGEIVLLKVIRLIDPQVDENEVLESLLPFLDAQYQRRPVIFHFDVTSSVRTGIWGFLFKLFILQYLMDVNGKMWLRNPRHLYIVEILEGNLALPWRPSKLSTLVPQFNFLDVFPKVTCRPPKEVINMELDPQQSYKEPGMDQRAFHSEIFQRPYQYLRRFHQKENLDTFQYQKGSVEGSPGECIQHLLIYSGVINPSWSELRNFAQFLNYQLQDCEASVFCHPSLVEDTLVGFKNFVVTFMIFMARDFATPTLHTSDQSPGKYMVTTADVEEEDLTPFSLRKRWESEPHPYIFFNSDHTSMTFIGFHFQSNQNGGVDAIDHLSGKVIKKDVMTVQLYQGLLLQRVPFNVDFDQLPRHEKIEKLCLALGIQWAIDPDETYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGAADAETMKLVKVHGGTTANMIYSKVREAEELARFNKAQYQLDTILFFDEANTTEAISCIKEVLCDHTVGGQPLAKNSGLHIIAACNPYRKHTQEMICRLESAGLGYRVSAEETAERLGSIPLRQLVYRVHALPPSLIPLVWDFGQLNDSAEKLYIHQIVQRLVKSIKVVQSETHVITEVLSASQGFMRERQNECSFVSLRDVERCVKVFKWFYDHSEMLLSKLASFLSETGVIQNDFERDPVLWSLVLAIGVCYHASLEKKESYRKAICKFFPAPYNDSRVILDEITRTQDLFLNGISLRKTIAKNFALKENVFMMVICIELKIPLFLVGKPGSSKSLAKTIVADAMQGQAAHSDLFRNLKQVHLVSFQCSPHSTPQGIIGTFKQCARFQQGKDLEQYVSVVVLDEVGLAEDSPKMPLKALHPLLEDGCIEDDPAPHKKVGFIGISNWALDPAKMNRGIFVSRGSPNKGELIESAKGICASEPLIQERIQGYFTSFAKAYKTVCKSQDKEFFGLRDYYSLIKMVFAAAKASNKKPSPQDIAHAILRNFSGKDDIHALDIFSANLPEAKYTEEVSTMQLIHQNIYGHLQKMHGRELDDSESRYLLVLTRNYVALQILQQAFFITDQPEIIFGSSFPKDQEYTQICQNINRVKICMETGKMVVLLNLQNLYESLYDALNQYYVYLGGQKYVDLGLGTHRVKCRVHPDFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKNIVEELKVWVEKFIDVKAEQFLARPKYSPSDVFIGYHSDTCASVVLQVLEQLGHEALTDELYQKVSEQAKSVLLDCATPDAVVRLKTSALGLFAESLLQEYCYRQQHNSFGDFLQAHLCTTDSERHAIFTEITTFSRLLTSHDCELLESEVKDWAVKLTILSLQQFDTKYSFLKEVRNCLVHVARYNILIIQTDFEDKIHSAQLIASAKHLTINEINKIQGNKDYILVCFITKLSRMGSGTSYVGFHGGLWHSVHIDDLRGSTVLVLDIPKLQDVAISQLFKPEDPPKVKEGCQIQEDGEEAMETEAVTSQQVADVEMETESPEKNTSPTSGPENDTQILDTTRLLRSCIQGAVGMLRDQNEYRQRSVRRVSILLSLLDKDATFLRAAKMRLYDLLKKQEENSVYDVKDWVVREAFNQDALQEAGTFRQTLWKRVQGAVTPLLASVISCVDRDGNLELLVSPHSPSWARDLWMFIFSDIKLLNIPLVTMDTRSKGKMSYTMVQNNMNISEKTSNSVPFSWRINDYLEDLWVHTQYITGNEGLAEKLLELFQKTSLGSFLAQFTVDQQQELLQCYLKDFLLLTMRVSTWEQLNVLQMALWSCVNQLNAGRPEEEVSLLSVHLAYHHFRSRLQNFSRILTIHSPILLSLTKGTQNHSWALREMSLDVLAAVACAEMLTENLLKPSPQAWLQTVKNLSMPLELLCSEGYMQDCGMMTRTLIRDIRTHWNRIFSISLFVEHVLLETESQIPELLELVTEYVSLLNKCLLEDSDTKTHRPFIAVMTTLRECKDQVTKSLSRFVVQPCPICLGDAQDPVCLPCDHIICLRCIEVHLTRGQMRCPHCLTNLPNTFSPTVSQEHREVIEKHARFRQMCNSFFVDLVSTMCFKDNSPPQKEVVKDLLSLLFVEKAPQRCCEHTKSLSPFDDVVDKTPVIRSVVLKLLLKYSFHDVKEYIQAYLSQLENKLFLAEDKTELYMFFTNCLEDSIYEKNNAFFIRDELKYLREEGQFLTTYQPVGCSQWPAGEASVEHMQKMARIRLCLDKASEILAELQDGSEVAEEKHRYLQQVERFCARVQNDWYRVYLVRKLTSQQGMEFVQSLSKEGHPAHWVFPKEVIAQQRDHPGQMDRYLVHGKDYKAVRDAVGRAILESKPLAIETALEACRSSTTQKAVYLLLALFREVTTLYRSQNADLHPKPQQCEAMKKFIEKSNTLSPDISAFAISLVNNELPLLRTGPGVSNLEGTVIEMAVHAATVLLCGQSQVLGPLKNSAFFPHLMVNAFLPTMPEDLLAQARNWKGLEEVTWYTCPNGHVCSVGECGKPMQQSFCIDCRAPIGGINHLPKEGFRVIKDTMDRTQTGHVLGNPPPRGAPVVSDRQMSPVVFLLIRLLTHLAMLLGATQSPQDLMNIIKPLVWDPKGFLQQHIQRDLEQLMNTLGRSADETASVVHLVLCRLLREQGHRSLNFDAQLSTRIQRNSWENLVQTLILRELEHLDKTLLAVNAQISQDERISSNPVAKIVYGDPVTFLPHLPKNSMVHCSKMWSCRKRITIEYLQHIVEQKNGKESVPILWKFLQKEAELRLVKFLPEILALQRNLVKRFQNVSEAEYRSIQSFISSHDSDGLKKLTRSRITIFLSTWNKLRRSLETNGEIKLPKDYCSSDLDLDTDLEVILPRRKGRGLCSTALVSYLIKLHNEIVYAVEKFSREDNSYSVDASEIADLHVISYEVERDLIPLILSNCQYQVEQGGETLQEFDLEKIQRQIISRFLQGKPRLTLKGLPTLVYRRDWNYEHLFMDIKNKMPQSPLPNSAITALRGQLQSYSDACEALSAIEVTLGFLSTAGGDPDMHLNVYIQDMLKMGDLTSLVSKALNRCKLKHTIALWQFLSAYKSEQLLRLGKKPFGEIDSRYKADLSPENAKLLNTFLNQIGLDAFLLELHEMMILKLKNPKIAESFNPEWSLRDTLVSYMETKDSEIPPEMESQFPEEILLSNCVAVWKMAAELKRNRQMR", "length": 4998, "header": "tr|G3N0D1-1|A0A3Q1LV49_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase RNF213 OS=Bos taurus OX=9913 GN=LOC512869 PE=3 SV=3 CANONICAL=A0A3Q1LV49-1" }, "locus": { "chromosome": "19", "start_pos": 52389767, "end_pos": 52121873, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066294.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066294.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055290.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055290.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:509283", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509283", "resource": "KEGG Pathway" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" }, { "name": "sprouting angiogenesis", "id": "GO:0002040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002040", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" }, { "name": "negative regulation of non-canonical Wnt signaling pathway", "id": "GO:2000051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000051", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" }, { "name": "immune system process", "id": "GO:0002376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002376", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" }, { "name": "lipid ubiquitination", "id": "GO:0120323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120323", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" }, { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1127, "end_pos": 1129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1267, "end_pos": 1269, "annotation": "n_glycosylation_sequon" }, { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1777, "end_pos": 1779, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2145, "end_pos": 2147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2531, "end_pos": 2533, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2627, "end_pos": 2629, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2757, "end_pos": 2759, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3027, "end_pos": 3029, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3311, "end_pos": 3313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3552, "end_pos": 3554, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3858, "end_pos": 3860, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3879, "end_pos": 3881, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3919, "end_pos": 3921, "annotation": "n_glycosylation_sequon" }, { "start_pos": 412, "end_pos": 414, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4824, "end_pos": 4826, "annotation": "n_glycosylation_sequon" }, { "start_pos": 820, "end_pos": 822, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" }, { "start_pos": 940, "end_pos": 942, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "R-BTA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983140" } ] }, { "id": "R-BTA-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4I9-1", "E1BJS7-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q1JQA1-1", "Q29RQ5-1", "Q32LN5-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0AAA9RXI4-1", "Q4U5R4-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983147" } ] }, { "id": "R-BTA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983156" } ] }, { "id": "R-BTA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MAR8", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MLB6", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] } ] }, { "uniprot_ac": "A0A3Q1MLH2", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1N3G7", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI4", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9RXX2", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] } ] }, { "uniprot_ac": "A0AAA9RZ14", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] } ] }, { "uniprot_ac": "A0AAA9S100", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TKS8", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9TWH7", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6DMH9", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NWC8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JN74", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A1A4I9", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "A1A4I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I9" } ] } ] }, { "uniprot_ac": "A3KN22", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5D7F8", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJC4", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A5PKG6", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] } ] }, { "uniprot_ac": "A6H795", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B782", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] } ] }, { "uniprot_ac": "E1B7D3", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] } ] }, { "uniprot_ac": "E1B7G3", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] } ] }, { "uniprot_ac": "E1B7Q7", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8R6", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BAV2", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BBN5", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] } ] }, { "uniprot_ac": "E1BBY2", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] } ] }, { "uniprot_ac": "E1BCU1", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] } ] }, { "uniprot_ac": "E1BCW1", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH71", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BID7", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BIP5", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] } ] }, { "uniprot_ac": "E1BIW0", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] } ] }, { "uniprot_ac": "E1BJS7", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BL26", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BNQ6", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MBM6", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MEX6", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MJ10", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] } ] }, { "uniprot_ac": "F1MJS5", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MLS5", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] } ] }, { "uniprot_ac": "F1MM41", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MTS8", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWS4", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1MYL0", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N1X8", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N3I3", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] } ] }, { "uniprot_ac": "F1N495", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F1N5G3", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] } ] }, { "uniprot_ac": "F1N645", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] } ] }, { "uniprot_ac": "F1N6G5", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] } ] }, { "uniprot_ac": "F1N703", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] } ] }, { "uniprot_ac": "F1N7A0", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P61085", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0II22", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0P5K3", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17QG5", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1JQA1", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RML1", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q1RMW1", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] } ] }, { "uniprot_ac": "Q1RMX2", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29RQ5", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2T9X7", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] } ] }, { "uniprot_ac": "Q2TA03", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] } ] }, { "uniprot_ac": "Q2TBP1", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2TBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBP1" } ] } ] }, { "uniprot_ac": "Q2TBU9", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2TBU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBU9" } ] } ] }, { "uniprot_ac": "Q32L27", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] } ] }, { "uniprot_ac": "Q32L40", "gene_name": "TCP1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q32L40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L40" } ] } ] }, { "uniprot_ac": "Q32LC7", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q32LC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LC7" } ] } ] }, { "uniprot_ac": "Q32LN1", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] } ] }, { "uniprot_ac": "Q32LN5", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] } ] }, { "uniprot_ac": "Q32P99", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] } ] }, { "uniprot_ac": "Q32PA5", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] } ] }, { "uniprot_ac": "Q3B7N1", "gene_name": "CHD1L", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q3B7N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7N1" } ] } ] }, { "uniprot_ac": "Q3MHL7", "gene_name": "CCT6A", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q3MHL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHL7" } ] } ] }, { "uniprot_ac": "Q3MHP1", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] } ] }, { "uniprot_ac": "Q3SZ40", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ40" } ] } ] }, { "uniprot_ac": "Q3SZ54", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3SZ54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZ54" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q3SZ54", 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"MEAEVGKLELMFQKADSDLDYIQYRLEYEIKTNYPDSAGKKNPVTLLKELSAIKSRYQTLPVRFKPIAVERKETESRICATFSKTMTLIQELQKETDLELLLLTEEEKTAAEQLRAHMSNL", "length": 121, "header": "tr|A0A3Q1LV51-1|A0A3Q1LV51_BOVIN Isoform 1 of Protein FAM33A OS=Bos taurus OX=9913 GN=LOC132343308 PE=3 SV=1 CANONICAL=A0A3Q1LV51-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LV51-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV51/entry", "sequence": { "sequence": "MEAEVGKLELMFQKADSDLDYIQYRLEYEIKTNYPDSAGKKNPVTLLKELSAIKSRYQTLPVRFKPIAVERKETESRICATFSKTMTLIQELQKETDLELLLLTEEEKTAAEQLRAHMSNL", "length": 121, "header": "tr|A0A3Q1LV51-1|A0A3Q1LV51_BOVIN Isoform 1 of Protein FAM33A OS=Bos taurus OX=9913 GN=LOC132343308 PE=3 SV=1 CANONICAL=A0A3Q1LV51-1" }, "locus": { "chromosome": "21", "start_pos": 5234186, "end_pos": 5233824, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048734.4", "url": "https://www.ensembl.org/id/ENSBTAT00000048734.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061250.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061250.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:132343308", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132343308", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV51", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV51" } ], "pmid": "" }, { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV51", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV51" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV51", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV51" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV51", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV51" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "spindle microtubule", "id": "GO:0005876", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005876", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV51", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV51" } ], "pmid": "" }, { "name": "outer kinetochore", "id": "GO:0000940", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000940", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV51", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV51" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LV51-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 121, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LV51-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LV51" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LV51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV51" }, { "id": "PF16740", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16740" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ska2 N-terminal", "eco_id": "ECO_0000259", "start_pos": 3, "end_pos": 114, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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{ "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LV66-1", "uniprot_ac": "A0A3Q1LV66", "uniprot_id": "A0A3Q1LV66_BOVIN", "mass": { "chemical_mass": 109766.0, "monoisotopic_mass": 109766.0 }, "refseq": { "ac": "XP_024849406", "name": "cytoplasmic polyadenylation element-binding protein 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849406" }, "gene_names": [ { "name": "CPEB2", "type": "recommended", "evidence": [ { "id": "A0A3Q1LV66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV66" } ] }, { "name": "CPEB2", "type": "synonym", "evidence": [ { "id": "XP_024849406", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849406" } ] } ], "protein_names": [ { "name": "Cytoplasmic polyadenylation element binding protein 2", "type": "synonym", "evidence": [ { "id": "A0A3Q1LV66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV66/entry#names_and_taxonomy" } ] }, { "name": "cytoplasmic polyadenylation element-binding protein 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024849406", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849406" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV66" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CPEB2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV66", "locus": { "chromosome": "6", "start_pos": 110216741, "end_pos": 110150735, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019847", "url": "https://www.ensembl.org/id/ENSBTAG00000019847" } ] } } ], "crossref": [ { "id": "A0A3Q1LV66", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LV66", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019847", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019847", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12724", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12724", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12726", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12726", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19757", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19757", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538880", "url": "https://www.ncbi.nlm.nih.gov/gene/538880", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032296", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032296", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034819", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034819", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038446", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038446", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538880", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538880", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LV66", "url": "https://www.orthodb.org/?gene=A0A3Q1LV66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWV1", "url": "https://www.orthodb.org/?gene=A0A3Q1LWV1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N436", "url": "https://www.orthodb.org/?gene=F1N436", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12566", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12566", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12566:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12566:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16367", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16367", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024849406", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849406", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV66-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWV1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWV1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1H4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1H4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1H4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N436", "url": "https://www.uniprot.org/uniprotkb/F1N436", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N436-1", "url": "https://www.uniprot.org/uniprotkb/F1N436-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRDFGFGVLHTAPLRSNSPGSLFSGGAYCPSAAGPAAPLPSATPFGPVSPPPLPVTGFSEAASPLSIPLGCGGADRSAAAAAAASSSSPFLAHQQTMQDELLLGLTQQPARPLSGAAATEKLPNHHPGGGTNAGVTHLLPSQDFKPSLHHPSSSSASCCCCRRTSSPQDFSKRQQQQLSSQKRKEFSPPHLPHPPDSKPPPPPLHCPGRFSPPPPPPGQLLQPAPIAQRQQPPPPPQFSLPHPQHLPPQDFAPRQRPADLPPLPQLQPSPPAASRRRHGGAGSPRKTPAAGEGSAAEPPNAGLAPSTPPVNPAPGSMESPNHPLLNSPSNLLPGGALGAGAFSSLQSPDLPHPGGGGGGGGSGGGGPPGGGGGGGSASPPPLPGFGTPWSVQTASPPPQSQPPPPPQQPPPPPPPQQPPQPQPQPPGSSAATPGGGGGGGGSLSAMPPPSPDSENGFYPGLPSSMNPAFFPSFSPVSPHGCAGLSVPASGGGGGGFGGPFSAAAVPPPPAMNLPQQQPPPPAAPQQPQSRRSPVSPQLQQQHQAAAAAFLQQRNSYNHHQPLLKQSPWSNHQSSGWGTGSMSWGAMHGRDHRRTGNMGLPGAMNQISPLKKPFSGNVIAPPKFTRSTPSLTPKSWIEDNVFRTDNNSNTLLPLQVRSSLQLPAWGSDSLQDSWCTAAGTSRIDQDRSRMYDSLNMHSLENSLIDIMRAEHDPLKGRLSYPHPGTDNLLMLNARSYGRRRGRSSLFPIDDGLLDDGHNDQVGVLNSPTCYSAHQNGERIERFSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECQGARCGGKFAPFFCANVTCLQYYCEFCWANIHSRAGREFHKPLVKEGADRPRQIHFRWN", "length": 1040, "header": "tr|A0A3Q1LV66-1|A0A3Q1LV66_BOVIN Isoform 1 of Cytoplasmic polyadenylation element binding protein 2 OS=Bos taurus OX=9913 GN=CPEB2 PE=3 SV=2 CANONICAL=A0A3Q1LV66-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LV66-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV66/entry", "sequence": { "sequence": 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"length": 1005, "header": "tr|F1N436-1|A0A3Q1LV66_BOVIN Computationally mapped isoform of Cytoplasmic polyadenylation element binding protein 2 OS=Bos taurus OX=9913 GN=CPEB2 PE=3 SV=5 CANONICAL=A0A3Q1LV66-1" }, "locus": { "chromosome": "6", "start_pos": 110215737, "end_pos": 110150934, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026443.8", "url": "https://www.ensembl.org/id/ENSBTAT00000026443.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026443.8", "url": "https://www.ensembl.org/id/ENSBTAP00000026443.8" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 432, "start_aa": "Thr", "end_pos": 432, "end_aa": "Thr", "residue": "Thr", "site_lbl": 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"name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV66" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV66" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cellular response to insulin stimulus", "id": "GO:0032869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV66" } ], "pmid": "" }, { "name": "cellular response to hypoxia", "id": "GO:0071456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV66" } ], "pmid": "" }, { "name": "negative regulation of cytoplasmic translation", "id": "GO:2000766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000766", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV66" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV66" } ], "pmid": "" }, { "name": "translation regulator activity", "id": "GO:0045182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045182", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV66", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV66" } ], "pmid": "" }, { "name": "mRNA regulatory element binding translation repressor activity", "id": "GO:0000900", "url": 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"uniprot_ac": "A0A3Q1LV78", "uniprot_id": "A0A3Q1LV78_BOVIN", "mass": { "chemical_mass": 174277.0, "monoisotopic_mass": 174277.0 }, "refseq": { "ac": "XP_059743025", "name": "ATP-binding cassette sub-family C member 9 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743025" }, "gene_names": [ { "name": "ABCC9", "type": "recommended", "evidence": [ { "id": "A0A3Q1LV78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV78" } ] }, { "name": "ABCC9", "type": "synonym", "evidence": [ { "id": "XP_059743025", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743025" } ] } ], "protein_names": [ { "name": "ATP binding cassette subfamily C member 9", "type": "synonym", "evidence": [ { "id": "A0A3Q1LV78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV78/entry#names_and_taxonomy" } ] }, { "name": "ATP-binding cassette sub-family C member 9 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059743025", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743025" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LV78", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV78" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABCC9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV78", "locus": { "chromosome": "5", "start_pos": 88442014, "end_pos": 88169116, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019294", "url": "https://www.ensembl.org/id/ENSBTAG00000019294" } ] } } ], "crossref": [ { "id": "ENSBTAG00000019294", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019294", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03288", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03288", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03290", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03290", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18591", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18591", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18602", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18602", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100336551", "url": "https://www.ncbi.nlm.nih.gov/gene/100336551", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047080", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047080", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100336551", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336551", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR24223", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24223:SF173", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF173", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00664", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00664", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1296025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5578775", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5578775", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059743025", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743025", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV78", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LV78-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJB7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJB7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3X0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3X0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH75", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SH75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH75-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8L0", "url": "https://www.uniprot.org/uniprotkb/E1B8L0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8L0-1", "url": "https://www.uniprot.org/uniprotkb/E1B8L0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLSFCGNNISSYNIYDGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQSGWGISDLRFCITGIMVILNGLLMAVEINVIRVRRYVFFVNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADDPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNETNNPTGASETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLQPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIVSVQKLNEFLLSDEIGEDSWRTGEGSLPFESCKKHTGVQPKTINRKQPGRYHLDNYEQSTRRLRPMETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNETEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQLEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSINSTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCVSAIGMISYATPVFLVALVPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADVEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSILDAGLVLVLSEGILVECDTVPNLLALKNGLFSTLVMTNK", "length": 1549, "header": "tr|A0A3Q1LV78-1|A0A3Q1LV78_BOVIN Isoform 1 of ATP binding cassette subfamily C member 9 OS=Bos taurus OX=9913 GN=ABCC9 PE=3 SV=2 CANONICAL=A0A3Q1LV78-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LV78-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV78/entry", "sequence": { "sequence": "MSLSFCGNNISSYNIYDGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQSGWGISDLRFCITGIMVILNGLLMAVEINVIRVRRYVFFVNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADDPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNETNNPTGASETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLQPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIVSVQKLNEFLLSDEIGEDSWRTGEGSLPFESCKKHTGVQPKTINRKQPGRYHLDNYEQSTRRLRPMETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNETEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQLEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSINSTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCVSAIGMISYATPVFLVALVPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADVEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSILDAGLVLVLSEGILVECDTVPNLLALKNGLFSTLVMTNK", "length": 1549, "header": "tr|A0A3Q1LV78-1|A0A3Q1LV78_BOVIN Isoform 1 of ATP binding cassette subfamily C member 9 OS=Bos taurus OX=9913 GN=ABCC9 PE=3 SV=2 CANONICAL=A0A3Q1LV78-1" }, "locus": { "chromosome": "5", "start_pos": 88408814, "end_pos": 88264171, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068051.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068051.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064511.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064511.2" } ] } }, { "isoform_ac": "A0A3Q1NJB7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJB7/entry", "sequence": { "sequence": "MSLSFCGNNISSYNIYDGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQSGWGISDLRFCITGIMVILNGLLMAVEINVIRVRRYVFFVNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADDPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNETNNPTGASETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLQPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIVSVQKLNEFLLSDEIGEDSWRTGEGSLPFESCKKHTGVQPKTINRKQPGRYHLDNYEQSTRRLRPMETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNETEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQLEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSINSTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCVSAIGMISYATPVFLVALVPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADVEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIADTRPRIGPFSSRSYRSCARRWDSKGPVRGRPASARTCGRPASGPESDGSRGKERQVADRCLGWLW", "length": 1569, "header": "tr|A0A3Q1NJB7-1|A0A3Q1NJB7_BOVIN Computationally mapped isoform of ATP binding cassette subfamily C member 9 OS=Bos taurus OX=9913 GN=ABCC9 PE=3 SV=2 CANONICAL=A0A3Q1LV78-1" }, "locus": { "chromosome": "5", "start_pos": 88435376, "end_pos": 88264171, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073196.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073196.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072221.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072221.2" } ] } }, { "isoform_ac": "A0AAA9S3X0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3X0/entry", "sequence": { "sequence": "MSLSFCGNNISSYNIYDGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLDFDYHEKKTNCYKHSC", "length": 151, "header": "tr|A0AAA9S3X0-1|A0A3Q1LV78_BOVIN Computationally mapped isoform of ATP binding cassette subfamily C member 9 OS=Bos taurus OX=9913 GN=ABCC9 PE=3 SV=1 CANONICAL=A0A3Q1LV78-1" }, "locus": { "chromosome": "5", "start_pos": 88274433, "end_pos": 88264171, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115429.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115429.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078491.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078491.1" } ] } }, { "isoform_ac": "A0AAA9SH75-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH75/entry", "sequence": { "sequence": "MSLSFCGNNISSYNIYDGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLGEYDHCCYFFPKNYLFSFSSE", "length": 156, "header": "tr|A0AAA9SH75-1|A0A3Q1LV78_BOVIN Computationally mapped isoform of ATP binding cassette subfamily C member 9 OS=Bos taurus OX=9913 GN=ABCC9 PE=3 SV=1 CANONICAL=A0A3Q1LV78-1" }, "locus": { "chromosome": "5", "start_pos": 88272155, "end_pos": 88264171, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127277.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127277.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085562.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085562.1" } ] } }, { "isoform_ac": "E1B8L0-1", "url": "https://www.uniprot.org/uniprotkb/E1B8L0/entry", "sequence": { "sequence": "MSLSFCGNNISSYNIYDGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQSGWGISDLRFCITGIMVILNGLLMAVEINVIRVRRYVFFVNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADDPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNETNNPTGASETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLQPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIVSVQKLNEFLLSDEIGEDSWRTGEGSLPFESCKKHTGVQPKTINRKQPGRYHLDNYEQSTRRLRPMETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNETEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQLEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATWTSEYSINSTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCVSAIGMISYATPVFLVALVPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADVEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAREDGVFASFVRADM", "length": 1549, "header": "tr|E1B8L0-1|E1B8L0_BOVIN Computationally mapped isoform of ATP binding cassette subfamily C member 9 OS=Bos taurus OX=9913 GN=ABCC9 PE=3 SV=4 CANONICAL=A0A3Q1LV78-1" }, "locus": { "chromosome": "5", "start_pos": 88412935, "end_pos": 88264171, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043069.6", "url": "https://www.ensembl.org/id/ENSBTAT00000043069.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040663.5", "url": "https://www.ensembl.org/id/ENSBTAP00000040663.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100336551", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336551", "resource": "KEGG Pathway" }, { "id": "R-BTA-1296025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296025", "resource": "Reactome", "description": "ATP sensitive Potassium channels" }, { "id": "R-BTA-382556", 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"MPYPELYHPSFVKPEEVDGGRRGPNLLCISSVSLSPLSPPPPRKQSGKLKLYRTRKSFSLISRAGPVVFYFFAHRPGQRFSMSQILFQQLVPLQVKCRDCEERRVSIRLSIELQSVSNPVHRKDLVIRLTDDADPFFLYNLVISEEDFQSLKFQQGLLVDFLAFPQKFIDLLQQCTQEYAKEIPRFLLQLVSTEAILDNSPALLNVVETNPFKHLTHLSLKLLPGNDVEIKKFLADCLKCSKEEKLSLTQSLDDVTRQLNFTQKTLSEKIQELDKLRNEWASHTATLSNKHSQELTNEKEKALQAQVQYQQQHEQQKKDLEILHQRNMQQLQNRLSELETANKDLTERKYKGDSTIRELKAKLSGVEEELQRAKQEVLSLRRENSTLDAECHEKEKHINQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVALEENGEKNQVQLGKLEATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEKLQKEQKELQDVGQSLRIKEQEVCKLQEQLEATVQKLEESKQLLKNNEKLITWLNKELNENQLVRKQDVLGPSTTPPVHSSSNTIRSGISPTSNVVEGRLTYPACGIGYPVSSAFAFQNTFSHPISAKNSIHTVSGPKVQFNLQFTKPNPSLGDVQSGTTISMPCSTDKENGENLGLESIYLKKREDSIPLRGLSQNLFNNPDHQKDGTLGALQTSSKLTVLPSASSAYFPGQLQNS", "length": 738, "header": "tr|A0A3Q1LVE2-1|A0A3Q1LVE2_BOVIN Isoform 1 of Spindle assembly abnormal protein 6 homolog OS=Bos taurus OX=9913 GN=SASS6 PE=4 SV=2 CANONICAL=A0A3Q1LVE2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVE2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVE2/entry", "sequence": { "sequence": "MPYPELYHPSFVKPEEVDGGRRGPNLLCISSVSLSPLSPPPPRKQSGKLKLYRTRKSFSLISRAGPVVFYFFAHRPGQRFSMSQILFQQLVPLQVKCRDCEERRVSIRLSIELQSVSNPVHRKDLVIRLTDDADPFFLYNLVISEEDFQSLKFQQGLLVDFLAFPQKFIDLLQQCTQEYAKEIPRFLLQLVSTEAILDNSPALLNVVETNPFKHLTHLSLKLLPGNDVEIKKFLADCLKCSKEEKLSLTQSLDDVTRQLNFTQKTLSEKIQELDKLRNEWASHTATLSNKHSQELTNEKEKALQAQVQYQQQHEQQKKDLEILHQRNMQQLQNRLSELETANKDLTERKYKGDSTIRELKAKLSGVEEELQRAKQEVLSLRRENSTLDAECHEKEKHINQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVALEENGEKNQVQLGKLEATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEKLQKEQKELQDVGQSLRIKEQEVCKLQEQLEATVQKLEESKQLLKNNEKLITWLNKELNENQLVRKQDVLGPSTTPPVHSSSNTIRSGISPTSNVVEGRLTYPACGIGYPVSSAFAFQNTFSHPISAKNSIHTVSGPKVQFNLQFTKPNPSLGDVQSGTTISMPCSTDKENGENLGLESIYLKKREDSIPLRGLSQNLFNNPDHQKDGTLGALQTSSKLTVLPSASSAYFPGQLQNS", "length": 738, "header": "tr|A0A3Q1LVE2-1|A0A3Q1LVE2_BOVIN Isoform 1 of Spindle assembly abnormal protein 6 homolog OS=Bos taurus OX=9913 GN=SASS6 PE=4 SV=2 CANONICAL=A0A3Q1LVE2-1" }, "locus": { "chromosome": "3", "start_pos": 43180193, "end_pos": 43140706, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075408.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075408.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064589.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064589.2" } ] } }, { "isoform_ac": "E1BAS3-1", "url": "https://www.uniprot.org/uniprotkb/E1BAS3/entry", "sequence": { "sequence": "MSQILFQQLVPLQVKCRDCEERRVSIRLSIELQSVSNPVHRKDLVIRLTDDADPFFLYNLVISEEDFQSLKFQQGLLVDFLAFPQKFIDLLQQCTQEYAKEIPRFLLQLVSTEAILDNSPALLNVVETNPFKHLTHLSLKLLPGNDVEIKKFLADCLKCSKEEKLSLTQSLDDVTRQLNFTQKAQVQYQQQHEQQKKDLEILHQRNMQQLQNRLSELETANKDLTERKYKGDSTIRELKAKLSGVEEELQRAKQEVLSLRRENSTLDAECHEKEKHINQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVALEENGEKNQVQLGKLEATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEKLQKEQKELQDVGQSLRIKEQEVCKLQEQLEATVQKLEESKQLLKNNEKLITWLNKELNENQLVRKQDVLGPSTTPPVHSSSNTIRSGISPTSNVVEGRLTYPACGIGYPVSSAFAFQNTFSHPISAKNSIHTVSGPKVQFNLQFTKPNPSLGDVQSGTTISMPCSTDKENGENLGLESIYLKKREDSIPLRGLSQNLFNNPDHQKDGTLGALQTSSKLTVLPSASSAYFPGQLQNS", "length": 617, "header": "tr|E1BAS3-1|A0A3Q1LVE2_BOVIN Computationally mapped isoform of Spindle assembly abnormal protein 6 homolog OS=Bos taurus OX=9913 GN=SASS6 PE=4 SV=2 CANONICAL=A0A3Q1LVE2-1" }, "locus": { "chromosome": "3", "start_pos": 43180193, "end_pos": 43140949, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020951.8", "url": "https://www.ensembl.org/id/ENSBTAT00000020951.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020951.6", "url": "https://www.ensembl.org/id/ENSBTAP00000020951.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of centriole replication", "id": "GO:0046601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046601", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVE2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVE2" } ], "pmid": "" }, { "name": "positive regulation of G1/S transition of mitotic cell cycle", "id": "GO:1900087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900087", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVE2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVE2" } ], "pmid": "" }, { "name": "centriole replication", "id": "GO:0007099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007099", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVE2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVE2" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVE2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVE2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVE2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVE2" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVE2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVE2" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVE2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVE2" } ], "pmid": "" }, { "name": "deuterosome", "id": "GO:0098536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098536", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVE2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVE2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 260, "end_pos": 262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LVE2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 738, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LVE2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LVE2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LVE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVE2" }, { "id": "PF18594", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18594" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAS-6 coiled-coil", "eco_id": "ECO_0000259", "start_pos": 227, "end_pos": 252, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LVE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVE2" }, { "id": "PF16531", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16531" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Spindle assembly abnormal protein 6 N-terminal", "eco_id": "ECO_0000259", "start_pos": 86, "end_pos": 222, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 260, "end_pos": 262 }, { "start_pos": 384, "end_pos": 386 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LVG5-1", "uniprot_ac": "A0A3Q1LVG5", "uniprot_id": "A0A3Q1LVG5_BOVIN", "mass": { "chemical_mass": 8645.0, "monoisotopic_mass": 8645.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Small VCP/p97-interacting protein", "type": "recommended", "evidence": [ { "id": "A0A3Q1LVG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVG5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVG5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVG5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVG5", "locus": {} } ], "crossref": [ { "id": "A0A3Q1LVG5", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LVG5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050652", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050652", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR031632", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031632", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GLKWQMN", "url": "https://omabrowser.org/oma/group/GLKWQMN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR35269", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35269", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35269:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35269:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15811", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15811", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LVG5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVG5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVG5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VGVCFPCPMETAPPSPDLREKRAKLAEAAERRQKEAASRSILNVQSVEEKRKKKEKIEKEMATSEPPPEGGLRWTVL", "length": 77, "header": "tr|A0A3Q1LVG5-1|A0A3Q1LVG5_BOVIN Isoform 1 of Small VCP/p97-interacting protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0A3Q1LVG5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVG5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVG5/entry", "sequence": { "sequence": "VGVCFPCPMETAPPSPDLREKRAKLAEAAERRQKEAASRSILNVQSVEEKRKKKEKIEKEMATSEPPPEGGLRWTVL", "length": 77, "header": "tr|A0A3Q1LVG5-1|A0A3Q1LVG5_BOVIN Isoform 1 of Small VCP/p97-interacting protein OS=Bos taurus OX=9913 GN= PE=4 SV=1 CANONICAL=A0A3Q1LVG5-1" }, "locus": { "chromosome": "5", "start_pos": 55780603, "end_pos": 55780373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076773.1", "url": "https://www.ensembl.org/id/ENSBTAT00000076773.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064623.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064623.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVG5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVG5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of autophagy", "id": "GO:0010508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVG5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVG5" } ], "pmid": "" }, { "name": "negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly", "id": "GO:1904240", "url": 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"evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009019", "url": "https://www.ensembl.org/id/ENSBTAG00000009019" } ] } } ], "crossref": [ { "id": "ENSBTAG00000009019", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009019", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06888", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06888", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12018", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12018", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12075", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12075", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12076", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12076", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12078", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12078", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518356", "url": "https://www.ncbi.nlm.nih.gov/gene/518356", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035480", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035480", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518356", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518356", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PMIPTKH", "url": "https://omabrowser.org/oma/group/PMIPTKH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVH9", "url": "https://www.orthodb.org/?gene=A0A3Q1LVH9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MW39", "url": "https://www.orthodb.org/?gene=F1MW39", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15706", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15706", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15706:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15706:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024837195", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837195", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVH9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVH9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MW39", "url": "https://www.uniprot.org/uniprotkb/F1MW39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MW39-1", "url": "https://www.uniprot.org/uniprotkb/F1MW39-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKKSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSGEPLPPKLAPGSPAHVGVLELDGVSRQQNSVGREKELLNNQRDGRLEGRPVPDGDIRQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVAQLRLGDAAAMENSSGSEASGPSRPLPDAPHSAGDSGTPWAKDWKGGKEVLRKASSDTSSCAGYEEISDPDLEEKPSLPPRKESIIKSEEELQERQRMEQFRGSSPKPPGMILPMIPAKHALPARDGRKAEPKPEKSKLFQLKNETGLECGHRVLAKEVKKPSLRPISKSKAGLPEEKPEAVPQNLFLKSKPQVRPKPAPSPRTEPPQGEDQVDICNLRSKLRPAKSQEKASVDGESSHQAGGGQDGAFSRGFPPGEGPGRAQDRTSKQEGPSPKEAPCRAPPRPAKTTDPVPKATPVPLQEASLQRPVVPPRRPPPPKKTSSSSRPLPEVRGPLPEVRGPLPEVRGPLPEVRGPQRESSEGKAAPAPGRALLVPPKAKPFLSNSSGGQDDMRGKGGLGPRMMGKTGENKEKVAAGPFPSTDGPKDLYVAVANFEGDQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKKP", "length": 928, "header": "tr|A0A3Q1LVH9-1|A0A3Q1LVH9_BOVIN Isoform 1 of SH3 and PX domain-containing protein 2B OS=Bos taurus OX=9913 GN=SH3PXD2B PE=3 SV=1 CANONICAL=A0A3Q1LVH9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVH9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH9/entry", "sequence": { "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKKSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSGEPLPPKLAPGSPAHVGVLELDGVSRQQNSVGREKELLNNQRDGRLEGRPVPDGDIRQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVAQLRLGDAAAMENSSGSEASGPSRPLPDAPHSAGDSGTPWAKDWKGGKEVLRKASSDTSSCAGYEEISDPDLEEKPSLPPRKESIIKSEEELQERQRMEQFRGSSPKPPGMILPMIPAKHALPARDGRKAEPKPEKSKLFQLKNETGLECGHRVLAKEVKKPSLRPISKSKAGLPEEKPEAVPQNLFLKSKPQVRPKPAPSPRTEPPQGEDQVDICNLRSKLRPAKSQEKASVDGESSHQAGGGQDGAFSRGFPPGEGPGRAQDRTSKQEGPSPKEAPCRAPPRPAKTTDPVPKATPVPLQEASLQRPVVPPRRPPPPKKTSSSSRPLPEVRGPLPEVRGPLPEVRGPLPEVRGPQRESSEGKAAPAPGRALLVPPKAKPFLSNSSGGQDDMRGKGGLGPRMMGKTGENKEKVAAGPFPSTDGPKDLYVAVANFEGDQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKKP", "length": 928, "header": "tr|A0A3Q1LVH9-1|A0A3Q1LVH9_BOVIN Isoform 1 of SH3 and PX domain-containing protein 2B OS=Bos taurus OX=9913 GN=SH3PXD2B PE=3 SV=1 CANONICAL=A0A3Q1LVH9-1" }, "locus": { "chromosome": "20", "start_pos": 4223384, "end_pos": 4104994, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077196.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077196.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064638.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064638.1" } ] } }, { "isoform_ac": "F1MW39-1", "url": "https://www.uniprot.org/uniprotkb/F1MW39/entry", "sequence": { "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKKSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSGEPLPPKLAPGSPAHVGVLELDGVSRQQNSVGREKELLNNQRDGRLEGRPVPDGDIRQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVAQLRLGDAAAMENSSGSEASGPSRPLPDAPHSAGDSGTPWAKDWKGGKEVLRKASSDTSSCAGYEEISDPDLEEKPSLPPRKESIIKSEEELQERQRMEQFRGSSPKPPGMILPMIPAKHALPARDGRKAEPKPEKSKLFQLKNETGLECGHRVLAKEVKKPSLRPISKSKAGLPEEKPEAVPQNLFLKSKPQVRPKPAPSPRTEPPQGEDQVDICNLRSKLRPAKSQEKASVDGESSHQAGGGQDGAFSRGFPPGEGPGRAQDRTSKQEGPSPKEAPCRAPPRPAKTTDPVPKATPVPLQEASLQRPVVPPRRPPPPKKTSSSSRPLPEVRGPLPEVRGPLPEVRGPQRESSEGKAAPAPGRALLVPPKAKPFLSNSSGGQDDMRGKGGLGPRMMGKTGENKEKVAAGPFPSTDGPKDLYVAVANFEGDQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKKP", "length": 921, "header": "tr|F1MW39-1|A0A3Q1LVH9_BOVIN Computationally mapped isoform of SH3 and PX domain-containing protein 2B OS=Bos taurus OX=9913 GN=SH3PXD2B PE=3 SV=4 CANONICAL=A0A3Q1LVH9-1" }, "locus": { "chromosome": "20", "start_pos": 4223384, "end_pos": 4104994, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011874.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011874.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011874.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011874.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518356", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518356", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YHJ6-1", "protein_name": "SH3 and PX domain-containing protein 2B", "gene_name": "SH3PXD2B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPRRSIAEVKVLDVQKRRIPNKHYVYIIKVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPDDLTPPKEEPIGKKKSGFIQRTTSFLQRGADSASVDPLVLEQYVVVANYQKQESSEISLCVGQLVDIIEKNESGWWFVSTSEEQGWVPATCLEAQDGVQDELSMQPDEVPWRYWSLPRHVGRRRTLGDLYTSGWGQEEKYTVIYPYTARDQDEMNLDKGAVVVVIQKNLEGWWKIRYQGQEGWAPASYLKKGNGEMFSQKLGSGSSAHSCALDLDGISRQQAVTSREKDGRFDNRPLPNADIRRKSPKMRQRPPPRRDLTIPRGLNLPKPPVPPQVEEEYYTIADFQTTIPDGISFQAGMKVEVIEKNLSGWWYIQIEEKEGWAPATFIDKYKKTSNASRPNFLAPLPSEMAQLRLGDAAAESSATEEATGPCRPLPEAPPNGMDCGMKRAKDWKGKEATESGDLAFTCGYEEISDRDVEEKPSLPPRKESIIKSEGELLERQRPPPKPPGMILPMIPPKQSAAPKDSKKPELKPEKGKLFQLKNEMGLECGHKVSAKEVKKPNLRPIVKPTKPKAEPVEDKTEPITQNPFLKSRPQIKPKPATAPRTDPPPADDKLDICSLRSKLRPAKCPEKPPEQDTAASESSCSTPAVAPEASGRFQERPSVESKALPKSPPGPAVAPAAREPTPQRPVVPPRRPPPPKKTTSPVAGPVPEARASPLPGRPMLVPPKARPFLSAAIQDEAKVKSSVGPKVISKAVERGEGRERTSAPFSNPDVSKEALYVAVADFEGDEETNSFREGTLFEVREKNSSGWWFCKVLTGGPCWEGWIPSNYLRKKP", "length": 904 }, "evidence": [ { "id": "A0A3Q1LVH9", "url": "https://omabrowser.org/oma/group/A0A3Q1LVH9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A1X283-1", "protein_name": "SH3 and PX domain-containing protein 2B", "gene_name": "SH3PXD2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP", "length": 911 }, "evidence": [ { "id": "A0A3Q1LVH9", "url": "https://omabrowser.org/oma/group/A0A3Q1LVH9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A2AAY5-1", "protein_name": "SH3 and PX domain-containing protein 2B", "gene_name": "Sh3pxd2b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP", "length": 908 }, "evidence": [ { "id": "A0A3Q1LVH9", "url": "https://omabrowser.org/oma/group/A0A3Q1LVH9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "M0RCP2-1", "protein_name": "SH3 and PX domain-containing protein 2B", "gene_name": "Sh3pxd2b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPVEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGSDPTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEVSWRYCSLPRSVGRRRTLGDLYAISWRQEEKYTVIYPYTARDQDEMNLERGVVVEVIQKNLEGWWKIRFQGKEGWAPASYLKKSSGEPLPPKLGPSSSAHSGALDLDGVSRQQNAVGREKELLNNQRDGRFEGRLAPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGEAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPHRGSSPKPPGVILPMIPAKHAPLARDSKKPEPKPDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELPEEKVEPNPQNLFLKSRPQVRPKPTPSPKTEPAQGEDQVDIYNLRSKLRPAKSQEKALLDGESHHAAGGHDTALGRSFLPGEGPGRGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGSQREESRAIPASGRALLVPPKAKPFLSNSSVGQDDIRGKGGLGPRIAGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCRVLSGAPSWEGWIPSNYLRKKP", "length": 935 }, "evidence": [ { "id": "A0A3Q1LVH9", "url": "https://omabrowser.org/oma/group/A0A3Q1LVH9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVH9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH9" } ], "pmid": "" }, { "name": "podosome", "id": "GO:0002102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002102", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVH9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVH9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH9" } ], "pmid": "" }, { "name": "extracellular matrix disassembly", "id": "GO:0022617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022617", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVH9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH9" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVH9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH9" } ], "pmid": "" }, { "name": "bone development", "id": "GO:0060348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060348", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVH9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH9" } ], "pmid": "" }, { "name": "protein localization to membrane", "id": "GO:0072657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072657", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVH9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH9" } ], "pmid": "" }, { "name": "eye development", "id": "GO:0001654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001654", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVH9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH9" } ], "pmid": "" }, { "name": "superoxide anion generation", "id": "GO:0042554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042554", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVH9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVH9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH9" } ], "pmid": "" }, { "name": "superoxide-generating NADPH oxidase activator activity", "id": "GO:0016176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016176", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVH9", "url": 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"evidence": [ { "id": "XP_002693995", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693995" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVL8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVL8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPATA17", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVL8", "locus": { "chromosome": "16", "start_pos": 21357135, "end_pos": 21125884, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000052073", "url": "https://www.ensembl.org/id/ENSBTAG00000052073" } ] } } ], "crossref": [ { "id": "A0A3Q1LVL8", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LVL8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000052073", "url": 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"A0A3Q1LVL8", "url": "https://www.orthodb.org/?gene=A0A3Q1LVL8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22706", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22706", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22706:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22706:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002693995", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693995", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVL8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVL8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N2X9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N2X9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2X9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATLARLQARSKSIAQQYYYRNSVVDIFRKKENDAAIKIQSWFRGCQVRAYIRYLHRVATIIQKRWRGYLGRQQYQVIVKLAYYTMKMNLYNAMAVRIQRRWRGYKIRKYCFNYYYLKEYLKAVSETNDAIREALEEFAEMKEREEKKADLEREEKERDYQARKMHYLLSTKQIPGIYNSPFRKDPDPWELRLQKAKPLTHRRPEVKRKRSICLSDWLACTSARSFPRSGILPPIDRKRCQGPFRDISEVLEQRYKPLEPTLRVAEPIDGLTEARAQLQKQEWARNVNDNMFLPFSSYHKNKKYVPTMHLSSKYGPDVYGTQHFRDENPKRWICNKDFQTVLPSFDLFSKYGKMYSKAGQIV", "length": 362, "header": "tr|A0A3Q1LVL8-1|A0A3Q1LVL8_BOVIN Isoform 1 of Spermatosis associated 17 OS=Bos taurus OX=9913 GN=SPATA17 PE=4 SV=1 CANONICAL=A0A3Q1LVL8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVL8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVL8/entry", "sequence": { "sequence": "MATLARLQARSKSIAQQYYYRNSVVDIFRKKENDAAIKIQSWFRGCQVRAYIRYLHRVATIIQKRWRGYLGRQQYQVIVKLAYYTMKMNLYNAMAVRIQRRWRGYKIRKYCFNYYYLKEYLKAVSETNDAIREALEEFAEMKEREEKKADLEREEKERDYQARKMHYLLSTKQIPGIYNSPFRKDPDPWELRLQKAKPLTHRRPEVKRKRSICLSDWLACTSARSFPRSGILPPIDRKRCQGPFRDISEVLEQRYKPLEPTLRVAEPIDGLTEARAQLQKQEWARNVNDNMFLPFSSYHKNKKYVPTMHLSSKYGPDVYGTQHFRDENPKRWICNKDFQTVLPSFDLFSKYGKMYSKAGQIV", "length": 362, "header": "tr|A0A3Q1LVL8-1|A0A3Q1LVL8_BOVIN Isoform 1 of Spermatosis associated 17 OS=Bos taurus OX=9913 GN=SPATA17 PE=4 SV=1 CANONICAL=A0A3Q1LVL8-1" }, "locus": { "chromosome": "16", "start_pos": 21357130, "end_pos": 21126069, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087028.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087028.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061221.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061221.1" } ] } }, { "isoform_ac": "A0A3Q1N2X9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2X9/entry", "sequence": { "sequence": "MATLARLQARSKSIAQQYYYRNSVVDIFRKKENDAAIKIQSWFRGCQVRAYIRYLHRVATIIQKRWRGYLGRQQYQVIVKIQRRWRGYKIRKYCFNYYYLKEYLKAVSETNDAIREALEEFAEMKEREEKKADLEREEKERDYQARKMHYLLSTKQIPGIYNSPFRKDPDPWELRLQKAKPLTHRRPEVKRKRSICLSDWLACTSARSFPRSGILPPIDRKRCQGPFRDISEVLEQRYKPLEPTLRVAEPIDGLTEARAQLQKQEWARNVNDNMFLPFSSYHKNKKYVPTMHLSSKYGPDVYGTQHFRDENPKRWICNKDFQTVLPSFDLFSKYGKMYSKAGQIV", "length": 345, "header": "tr|A0A3Q1N2X9-1|A0A3Q1LVL8_BOVIN Computationally mapped isoform of Spermatosis associated 17 OS=Bos taurus OX=9913 GN=SPATA17 PE=4 SV=2 CANONICAL=A0A3Q1LVL8-1" }, "locus": { "chromosome": "16", "start_pos": 21357130, "end_pos": 21126069, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079877.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079877.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063697.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063697.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618365", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618365", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YND7-1", "protein_name": "Spermatosis associated 17", "gene_name": "SPATA17", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAALVRLETRLSRLREEYFLKNRSVDEDRKIVYKAAVKIQSWFRGCRVRAYLRYLNKMAISIQKWWRGYQSRRYFRKMIKTAYFIMKMNFYNEMAVRIQKRWRGYYVRKYTHNYYALKKYLEAISLNNEIVRNELQEYAEMNEKKKKKKDLEKKEKEKKYKARKMHYLLSTEQIAGIYNSPFRKFPDPMELLLRQSKPLSHRQQQPKSPFTYDLYDWPTCKRPPAFPTGEPLPPIGRQKPQGPFRDAAEVLRQRYKPLEPTLRVAASISSPLEKAREEMKREEWRKCIHDNEFLPFSSYHKNEKYELSIHASEKIGKETYGIKHFREVQPNKWIAGKIYLLHHCSSSFSLLIYILFEIHLFRGTVEVEFLYFLKMNCPTR", "length": 380 }, "evidence": [ { "id": "A0A3Q1LVL8", "url": "https://omabrowser.org/oma/group/A0A3Q1LVL8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q96L03-1", "protein_name": "Spermatogenesis-associated protein 17", "gene_name": "SPATA17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATLARLQARSSTVGNQYYFRNSVVDPFRKKENDAAVKIQSWFRGCQVRAYIRHLNRIVTIIQKWWRSFLGRKQYQLTVQVAYYTMMMNLYNAMAVRIQRRWRGYRVRKYLFNYYYLKEYLKVVSETNDAIRKALEEFAEMKEREEKKANLEREEKKRDYQARKMHYLLSTKQIPGIYNSPFRKEPDPWELQLQKAKPLTHRRPKVKQKDSTSLTDWLACTSARSFPRSEILPPINRKQCQGPFRDITEVLEQRYRPLEPTLRVAEPIDELKLAREELRREEWLQNVNDNMFLPFSSYHKNEKYIPSMHLSSKYGPISYKEQFRSENPKKWICDKDFQTVLPSFELFSKYGKLYSKAGQIV", "length": 361 }, "evidence": [ { "id": "A0A3Q1LVL8", "url": "https://omabrowser.org/oma/group/A0A3Q1LVL8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D552-1", "protein_name": "Spermatogenesis-associated protein 17", "gene_name": "Spata17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METNSNNFGELQELKDMATLAKLLARAPFLESQYYFRNRAVDSFRKFENDAAVMIQSWFRGCQVRAYMRHLNRVVTIIQKWWRSYLGRKFYQLVVEAAYYTMKMNLYNEMAVRIQRRWRGFRIRKYCFNYYYLKEYLRAVSETNDAIREALEEFAEMKEREERKVLLEREEKQKDYQARKMHYLLSTKQISGIYNSPFREHPDPWELRLQKAKPLGHQKYTAEKGKTSQSPSNWLACTSVHSFPQSESLPPISRKRCQGPFRDINEVLEQRYKPLEPTLRVAEPINHLRLAREAFKQEERMRNVQDKMFLPFSSYHKKEKYIPMIHSSSAYNSDSYGQKHFRSQDSKKWISDKDFQTVLPSFQLFSKYGKLYSKAGEIV", "length": 379 }, "evidence": [ { "id": "A0A3Q1LVL8", "url": "https://omabrowser.org/oma/group/A0A3Q1LVL8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVL8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVL8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVL8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVL8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LVL8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 362, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LVL8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LVL8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LVN6-1", "uniprot_ac": "A0A3Q1LVN6", "uniprot_id": "A0A3Q1LVN6_BOVIN", "mass": { "chemical_mass": 182007.0, "monoisotopic_mass": 182007.0 }, "refseq": { "ac": "XP_015330689", "name": "PR domain zinc finger protein 2 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330689" }, "gene_names": [ { "name": "PRDM2", "type": "recommended", "evidence": [ { "id": "A0A3Q1LVN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN6" } ] }, { "name": "PRDM2", "type": "synonym", "evidence": [ { "id": "XP_015330689", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330689" } ] } ], "protein_names": [ { "name": "PR domain zinc finger protein 2", "type": "recommended", "evidence": [ { "id": "A0A3Q1LVN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN6/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.355", "type": "synonym", "evidence": [ { "id": "A0A3Q1LVN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN6/entry#names_and_taxonomy" } ] }, { "name": "PR domain zinc finger protein 2 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_015330689", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330689" } ] }, { "name": "PR domain-containing protein 2", "type": "synonym", "evidence": [ { "id": "A0A3Q1LVN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN6/entry#names_and_taxonomy" } ] }, { "name": "Retinoblastoma protein-interacting zinc finger protein", "type": "synonym", "evidence": [ { "id": "A0A3Q1LVN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN6/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein RIZ", "type": "synonym", "evidence": [ { "id": "A0A3Q1LVN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M117", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M117#function" }, { "database": "UniProtKB", "id": "ARBA00058611", "url": "https://www.uniprot.org/uniprotkb/ARBA00058611#function" }, { "database": "UniProtKB", "id": "A0A3Q1M1G6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1G6#function" }, { "database": "UniProtKB", "id": "A0A3Q1LVN6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN6#function" }, { "database": "UniProtKB", "id": "A0AAA9TUN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUN4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVN6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRDM2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN6", "locus": { "chromosome": "16", "start_pos": 53790017, "end_pos": 53921927, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020552", "url": "https://www.ensembl.org/id/ENSBTAG00000020552" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020552", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020552", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19188", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19188", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "789222", "url": "https://www.ncbi.nlm.nih.gov/gene/789222", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044414", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044414", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050331", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050331", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M9T9", "url": "https://www.orthodb.org/?gene=A0A3Q1M9T9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21549", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21549", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015330689", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330689", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "60276", "url": "https://www.rhea-db.org/rhea/60276", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LVN6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVN6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M117", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M117", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M117-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M117-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1G6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1G6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1G6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1G6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9T9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9T9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M9T9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9T9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTN2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTN2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTN2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N790", "url": "https://www.uniprot.org/uniprotkb/F1N790", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N790-1", "url": "https://www.uniprot.org/uniprotkb/F1N790-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNQNAAEPVVATETLAGVPEHVFRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGKKKSQESKNKANKTEDIQLKTSEPDPSPANMRDSAEGPKDEDENPSASTTEQPAIPQEAVSQDVPPDLALPPPAHEPQTGPDSELEAALCEANEVVEEEEEEEEEELEEEGDEAADVPNESSLRELEIRCDEKPEDLLEEPKTVSKETLADSAEAAPVVKTPRAREEANGDVFETFLFPCQHCERKFTTKQGLERHMHIHMSTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKLEDPAGGKAPSDGAPPQDDAQPPGLGQDGLTLSSEKASQDSVTPSVVEENGEAKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLLEEPQPPAEQAPPTPSVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTSSSTSNCDVIEMESNSADLYGINCLLTPVTVEITQNIKTTQVPITDDLPKEPSSSTNSESKKRRTASPPVLPKIKAETESDPATPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPPVGISAAEIPKLGPLCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPGDGKAAWTEAVLSSKKPKLESHSNSPAWSLSGRDERETGSPPGFDEYKVSKEWAASSTFSNVCNQQPLDLSSGMKQKAEGPGKAPVQWEAVLDLSVHKKPCGDSEGKEFKENHVLQPSCSAIKKRKPTTCMLQKVLLNEYNGVDLPVENTPDVSGSASPCKPLDPQPDSDRGLNSSLSAAVVESLPDVSSSSPALQPSSLSCGRLPPLLTPTTPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSGASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPSVEPVMSAASPGPPTLSSSSSSSSSSSFSSSSSSSSPSPPPLSAVSSVVSSGDNLETSLPMISFKQEELESEDLKAREEAPSTTEQEIVQETFNRNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKVKTDLSEHRFMLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLEASKEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRSPLGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKTTPESSSHVCPYCHREFTYIGSLNKHAAFSCPKKPVSPSKKKLSHSSKKGGHPSPAGSDRNNSSSHRRRTADAEIKMQSMQAPLGKTRARSSGPSQVPPPPSSFRSKQNVKFAASVKSKKPSSSLRNSSPIRMAKMTHSETKKPKAAAKNHAAPLSGKMSRSLHVRAQKSRAVLQSKSALASKKRTDRFSVKSRERSGGPITRSLQLAASADPSENRKEDGSGKQELKDLRSGLQRQK", "length": 1666, "header": "tr|A0A3Q1LVN6-1|A0A3Q1LVN6_BOVIN Isoform 1 of PR domain zinc finger protein 2 OS=Bos taurus OX=9913 GN=PRDM2 PE=4 SV=1 CANONICAL=A0A3Q1LVN6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVN6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVN6/entry", "sequence": { "sequence": "MNQNAAEPVVATETLAGVPEHVFRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGKKKSQESKNKANKTEDIQLKTSEPDPSPANMRDSAEGPKDEDENPSASTTEQPAIPQEAVSQDVPPDLALPPPAHEPQTGPDSELEAALCEANEVVEEEEEEEEEELEEEGDEAADVPNESSLRELEIRCDEKPEDLLEEPKTVSKETLADSAEAAPVVKTPRAREEANGDVFETFLFPCQHCERKFTTKQGLERHMHIHMSTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKLEDPAGGKAPSDGAPPQDDAQPPGLGQDGLTLSSEKASQDSVTPSVVEENGEAKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLLEEPQPPAEQAPPTPSVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTSSSTSNCDVIEMESNSADLYGINCLLTPVTVEITQNIKTTQVPITDDLPKEPSSSTNSESKKRRTASPPVLPKIKAETESDPATPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPPVGISAAEIPKLGPLCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPGDGKAAWTEAVLSSKKPKLESHSNSPAWSLSGRDERETGSPPGFDEYKVSKEWAASSTFSNVCNQQPLDLSSGMKQKAEGPGKAPVQWEAVLDLSVHKKPCGDSEGKEFKENHVLQPSCSAIKKRKPTTCMLQKVLLNEYNGVDLPVENTPDVSGSASPCKPLDPQPDSDRGLNSSLSAAVVESLPDVSSSSPALQPSSLSCGRLPPLLTPTTPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSGASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPSVEPVMSAASPGPPTLSSSSSSSSSSSFSSSSSSSSPSPPPLSAVSSVVSSGDNLETSLPMISFKQEELESEDLKAREEAPSTTEQEIVQETFNRNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKVKTDLSEHRFMLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLEASKEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRSPLGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKTTPESSSHVCPYCHREFTYIGSLNKHAAFSCPKKPVSPSKKKLSHSSKKGGHPSPAGSDRNNSSSHRRRTADAEIKMQSMQAPLGKTRARSSGPSQVPPPPSSFRSKQNVKFAASVKSKKPSSSLRNSSPIRMAKMTHSETKKPKAAAKNHAAPLSGKMSRSLHVRAQKSRAVLQSKSALASKKRTDRFSVKSRERSGGPITRSLQLAASADPSENRKEDGSGKQELKDLRSGLQRQK", "length": 1666, "header": "tr|A0A3Q1LVN6-1|A0A3Q1LVN6_BOVIN Isoform 1 of PR domain zinc finger protein 2 OS=Bos taurus OX=9913 GN=PRDM2 PE=4 SV=1 CANONICAL=A0A3Q1LVN6-1" }, "locus": { "chromosome": "16", "start_pos": 53904080, "end_pos": 53810733, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086222.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086222.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059386.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059386.1" } ] } }, { "isoform_ac": "A0A3Q1M117-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M117/entry", "sequence": { "sequence": "MNQNAAEPVVATETLAGVPEHVFRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGKKKSQESKNKANKTEDIQLKTSEPDPSPANMRDSAEGPKDEDENPSASTTEQPAIPQEAVSQDVPPDLALPPPAHEPQTGPDSELEAALCEANEVVEEEEEEEEEELEEEGDEAADVPNESSLRELEIRCDEKPEDLLEEPKTVSKETLADSAEAAPVVKTPRAREEANGDVFETFLFPCQHCERKFTTKQGLERHMHIHMSTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKLEDPAGGKAPSDGAPPQDDAQPPGLGQDGLTLSSEKASQDSVTPSVVEENGEAKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLLEEPQPPAEQAPPTPSVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTSSSTSNCDVIEMESNSADLYGINCLLTPVTVEITQNIKTTQVPITDDLPKEPSSSTNSESKKRRTASPPVLPKIKAETESDPATPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPPVGISAAEIPKLGPLCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPGDGKAAWTEAVLSSKKPKLESHSNSPAWSLSGRDERETGSPPGFDEYKVSKEWAASSTFSNVCNQQPLDLSSGMKQKAEGPGKAPVQWEAVLDLSVHKKPCGDSEGKEFKENHVLQPSCSAIKKRKPTTCMLQKVLLNEYNGVDLPVENTPDVSGSASPCKPLDPQPDSDRGLNSSLSAAVVESLPDVSSSSPALQPSSLSCGRLPPLLTPTTPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSGASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPSVEPVMSAASPGPPTLSSSSSSSSSSSFSSSSSSSSPSPPPLSAVSSVVSSGDNLETSLPMISFKQEELESEDLKAREEAPSTTEQEIVQETFNRNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKVKTDLSEHRFMLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLEASKEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRSPLGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKTTPESSSHVCPYCHREFTYIGSLNKHAAFSCPKKPVSPSKKKLSHSSKKGGHPSPAGSDRNNSSSHRRRTADAEIKMQSMQAPLGKTRARSSGPSQVPPPPSSFRSKQNVKFAASVKSKKPSSSLRNSSPIRMAKMTHSETKKPKAAAKNHAAPLSGKMSRSLHVRAQKSRAVLQSKSALASKKRTDRFSVKSRERSGGPITRSLQLAASADPSENRKEDGSGKQELKDLSQLRTCK", "length": 1665, "header": "tr|A0A3Q1M117-1|A0A3Q1LVN6_BOVIN Computationally mapped isoform of PR domain zinc finger protein 2 OS=Bos taurus OX=9913 GN=PRDM2 PE=4 SV=2 CANONICAL=A0A3Q1LVN6-1" }, "locus": { "chromosome": "16", "start_pos": 53904080, "end_pos": 53826218, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076043.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076043.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063385.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063385.2" } ] } }, { "isoform_ac": "A0A3Q1M1G6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1G6/entry", "sequence": { "sequence": "MNQNAAEPVVATETLAGVPEHVFRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGKKKSQESKNKANKTEDIQLKTSEPDPSPANMRDSAEGPKDEDENPSASTTEQPAIPQEAVSQDVPPDLALPPPAHEPQTGPDSELEAALCEANEVVEEEEEEEEEELEEEGDEAADVPNESSLRELEIRCDEKPEDLLEEPKTVSKETLADSAEAAPVVKTPRAREEANGDVFETFLFPCQHCERKFTTKQGLERHMHIHMSTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKLEDPAGGKAPSDGAPPQDDAQPPGLGQDGLTLSSEKASQDSVTPSVVEENGEAKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLLEEPQPPAEQAPPTPSVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTSSSTSNCDVIEMESNSADLYGINCLLTPVTVEITQNIKTTQVPITDDLPKEPSSSTNSESKKRRTASPPVLPKIKAETESDPATPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPPVGISAAEIPKLGPLCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPGDGKAAWTEAVLSSKKPKLESHSNSPAWSLSGRDERETGSPPGFDEYKVSKEWAASSTFSNVCNQQPLDLSSGMKQKAEGPGKAPVQWEAVLDLSVHKKPCGDSEGKEFKENHVLQPSCSAIKKRKPTTCMLQKVLLNEYNGVDLPVENTPDVSGSASPCKPLDPQPDSDRGLNSSLSAAVVESLPDVSSSSPALQPSSLSCGRLPPLLTPTTPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSGASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPSVEPVMSAASPGPPTLSSSSSSSSSSSFSSSSSSSSPSPPPLSAVSSVVSSGDNLETSLPMISFKQEELESEDLKAREEAPSTTEQEIVQETFNRNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKVKTDLSEHRFMLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLEASKEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRSPLGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKTTPESSSHVCPYCHREFTYIGSLNKHAAFSCPKKPVSPSKKKLSHSSKKGGHPSPAGSDRNNSSSHRRRTADAEIKMQSMQAPLGKTRARSSGPSQVPPPPSSFRSKQNVKFAASVKSKKPSSSLRNSSPIRMAKMTHSETKKPKAAAKNHAAPLSGKMSRSLHVRAQKSRAVLQSKSALASKKRTDRFSVKSRERSGGPITRSLQLAASADPSENRKEDGSGKQELKDLR", "length": 1659, "header": "tr|A0A3Q1M1G6-1|A0A3Q1LVN6_BOVIN Computationally mapped isoform of PR domain zinc finger protein 2 OS=Bos taurus OX=9913 GN=PRDM2 PE=4 SV=2 CANONICAL=A0A3Q1LVN6-1" }, "locus": { "chromosome": "16", "start_pos": 53904080, "end_pos": 53829275, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076597.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076597.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063558.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063558.2" } ] } }, { "isoform_ac": "A0A3Q1M9T9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9T9/entry", "sequence": { "sequence": "MWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGKKKSQESKNKANKTEDIQLKTSEPDPSPANMRDSAEGPKDEDENPSASTTEQPAIPQEAVSQDVPPDLALPPPAHEPQTGPDSELEAALCEANEVVEEEEEEEEEELEEEGDEAADVPNESSLRELEIRCDEKPEDLLEEPKTVSKETLADSAEAAPVVKTPRAREEANGDVFETFLFPCQHCERKFTTKQGLERHMHIHMSTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKLEDPAGGKAPSDGAPPQDDAQPPGLGQDGLTLSSEKASQDSVTPSVVEENGEAKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLLEEPQPPAEQAPPTPSVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTSSSTSNCDVIEMESNSADLYGINCLLTPVTVEITQNIKTTQVPITDDLPKEPSSSTNSESKKRRTASPPVLPKIKAETESDPATPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPPVGISAAEIPKLGPLCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPGDGKAAWTEAVLSSKKPKLESHSNSPAWSLSGRDERETGSPPGFDEYKVSKEWAASSTFSNVCNQQPLDLSSGMKQKAEGPGKAPVQWEAVLDLSVHKKPCGDSEGKEFKENHVLQPSCSAIKKRKPTTCMLQKVLLNEYNGVDLPVENTPDVSGSASPCKPLDPQPDSDRGLNSSLSAAVVESLPDVSSSSPALQPSSLSCGRLPPLLTPTTPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSGASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPSVEPVMSAASPGPPTLSSSSSSSSSSSFSSSSSSSSPSPPPLSAVSSVVSSGDNLETSLPMISFKQEELESEDLKAREEAPSTTEQEIVQETFNRNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKVKTDLSEHRFMLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLEASKEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRSPLGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKTTPESSSHVCPYCHREFTYIGSLNKHAAFSCPKKPVSPSKKKLSHSSKKGGHPSPAGSDRNNSSSHRRRTADAEIKMQSMQAPLGKTRARSSGPSQVPPPPSSFRSKQNVKFAASVKSKKPSSSLRNSSPIRMAKMTHSETKKPKAAAKNHAAPLSGKMSRSLHVRAQKSRAVLQSKSALASKKRTDRFSVKSRERSGGPITRSLQLAASADPSENRKEDGSGKQELKDLSYSLRLASRCPPPAAPYITRQCRNVKGHSCSPAPGIPLQRHLK", "length": 1627, "header": "tr|A0A3Q1M9T9-1|A0A3Q1LVN6_BOVIN Computationally mapped isoform of PR domain zinc finger protein 2 OS=Bos taurus OX=9913 GN=PRDM2 PE=4 SV=2 CANONICAL=A0A3Q1LVN6-1" }, "locus": { "chromosome": "16", "start_pos": 53884807, "end_pos": 53790903, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067363.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067363.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065254.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065254.2" } ] } }, { "isoform_ac": "A0A3Q1MTN2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTN2/entry", "sequence": { "sequence": "MRDSAEGPKDEDENPSASTTEQPAIPQEAVSQDVPPDLALPPPAHEPQTGPDSELEAALCEANEVVEEEEEEEEEELEEEGDEAADVPNESSLRELEIRCDEKPEDLLEEPKTVSKETLADSAEAAPVVKTPRAREEANGDVFETFLFPCQHCERKFTTKQGLERHMHIHMSTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKLEDPAGGKAPSDGAPPQDDAQPPGLGQDGLTLSSEKASQDSVTPSVVEENGEAKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLLEEPQPPAEQAPPTPSVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTSSSTSNCDVIEMESNSADLYGINCLLTPVTVEITQNIKTTQVPITDDLPKEPSSSTNSESKKRRTASPPVLPKIKAETESDPATPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPPVGISAAEIPKLGPLCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPGDGKAAWTEAVLSSKKPKLESHSNSPAWSLSGRDERETGSPPGFDEYKVSKEWAASSTFSNVCNQQPLDLSSGMKQKAEGPGKAPVQWEAVLDLSVHKKPCGDSEGKEFKENHVLQPSCSAIKKRKPTTCMLQKVLLNEYNGVDLPVENTPDVSGSASPCKPLDPQPDSDRGLNSSLSAAVVESLPDVSSSSPALQPSSLSCGRLPPLLTPTTPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSGASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPSVEPVMSAASPGPPTLSSSSSSSSSSSFSSSSSSSSPSPPPLSAVSSVVSSGDNLETSLPMISFKQEELESEDLKAREEAPSTTEQEIVQETFNRNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKVKTDLSEHRFMLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLEASKEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRSPLGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKTTPESSSHVCPYCHREFTYIGSLNKHAAFSCPKKPVSPSKKKLSHSSKKGGHPSPAGSDRNNSSSHRRRTADAEIKMQSMQAPLGKTRARSSGPSQVPPPPSSFRSKQNVKFAASVKSKKPSSSLRNSSPIRMAKMTHSETKKPKAAAKNHAAPLSGKMSRSLHVRAQKSRAVLQSKSALASKKRTDRFSVKSRERSGGPITRSLQLAASADPSENRKEDGSGKQELKDLRNFL", "length": 1461, "header": "tr|A0A3Q1MTN2-1|A0A3Q1LVN6_BOVIN Computationally mapped isoform of PR domain zinc finger protein 2 OS=Bos taurus OX=9913 GN=PRDM2 PE=4 SV=2 CANONICAL=A0A3Q1LVN6-1" }, "locus": { "chromosome": "16", "start_pos": 53840017, "end_pos": 53825909, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079197.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079197.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073708.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073708.2" } ] } }, { "isoform_ac": "A0AAA9SJ40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ40/entry", "sequence": { "sequence": "MNQNAAEPVVATETLAGVPEHVFRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGKKKSQESKNKANKTEDIQLKTSEPDPSPANMRDSAEGPKDEDENPSASTTEQPAIPQEAVSQDVPPDLALPPPAHEPQTGPDSELEAALCEANEVVEEEEEEEEEELEEEGDEAADVPNESSLRELEIRCDEKPEDLLEEPKTVSKETLADSAEAAPVVKTPRAREEANGDVFETFLFPCQHCERKFTTKQGLERHMHIHMSTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKLEDPAGGKAPSDGAPPQDDAQPPGLGQDGLTLSSEKASQDSVTPSVVEENGEAKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLLEEPQPPAEQAPPTPSVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTSSSTSNCDVIEMESNSADLYGINCLLTPVTVEITQNIKTTQVPITDDLPKEPSSSTNSESKKRRTASPPVLPKIKAETESDPATPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPPVGISAAEIPKLGPLCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPGDGKAAWTEAVLSSKKPKLESHSNSPAWSLSGRDERETGSPPGFDEYKVSKEWAASSTFSNVCNQQPLDLSSGMKQKAEGPGKAPVQWEAVLDLSVHKKPCGDSEGKEFKENHVLQPSCSAIKKRKPTTCMLQKVLLNEYNGVDLPVENTPDVSGSASPCKPLDPQPDSDRGLNSSLSAAVVESLPDVSSSSPALQPSSLSCGRLPPLLTPTTPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSGASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPSVEPVMSAASPGPPTLSSSSSSSSSSSFSSSSSSSSPSPPPLSAVSSVVSSGDNLETSLPMISFKQEELESEDLKAREEAPSTTEQEIVQETFNRNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKVKTDLSEHRFMLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLEASKEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRSPLGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKTTPESSSHVCPYCHREFTYIGSLNKHAAFSCPKKPVSPSKKKLSHSSKKGGHPSPAGSDRNNSSSHRRRTADAEIKMQSMQAPLGKTRARSSGPSQVPPPPSSFRSKQNVKFAASVKSKKPSSSLRNSSPIRMAKMTHSETKKPKAAAKNHAAPLSGKMSRSLHVRAQKSRAVLQSKSALASKKRTDRFSVKSRERSGGPITRSLQLAASADPSENRKEDGSGKQELKDLR", "length": 1608, "header": "tr|A0AAA9SJ40-1|A0A3Q1LVN6_BOVIN Computationally mapped isoform of PR domain zinc finger protein 2 OS=Bos taurus OX=9913 GN=PRDM2 PE=4 SV=1 CANONICAL=A0A3Q1LVN6-1" }, "locus": { "chromosome": "16", "start_pos": 53904080, "end_pos": 53829275, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099902.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099902.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085353.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085353.1" } ] } }, { "isoform_ac": "A0AAA9SZU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZU6/entry", "sequence": { "sequence": "MNQNAAEPVVATETLAGVPEHVFRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGKKKSQESKNKANKTEDIQLKTSEPDPSPANMRDSAEATVSAWHPDVLRQLPRTSPDSVGMSKPQLQPSSRDPSSKSRCFACSLTAPEVTWSQ", "length": 263, "header": "tr|A0AAA9SZU6-1|A0A3Q1LVN6_BOVIN Computationally mapped isoform of PR domain zinc finger protein 2 OS=Bos taurus OX=9913 GN=PRDM2 PE=4 SV=1 CANONICAL=A0A3Q1LVN6-1" }, "locus": { "chromosome": "16", "start_pos": 53904080, "end_pos": 53790889, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111051.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111051.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092002.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092002.1" } ] } }, { "isoform_ac": "A0AAA9TUN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUN4/entry", "sequence": { "sequence": "MNQNAAEPVVATETLAGVPEHVFRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGKKKSQESKNKANKTEDIQLKTSEPDPSPANMRDSAEGPKDEDENPSASTTEQPAIPQEAVSQDVPPDLALPPPAHEPQTGPDSELEAALCEANEVVEEEEEEEEEELEEEGDEAADVPNESSLRELEIRCDEKPEDLLEEPKTVSKETLADSAEAAPVVKTPRAREEANGDVFETFLFPCQHCERKFTTKQGLERHMHIHMSTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKLEDPAGGKAPSDGAPPQDDAQPPGLGQDGLTLSSEKASQDSVTPSVVEENGEAKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLLEEPQPPAEQAPPTPSVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTSSSTSNCDVIEMESNSADLYGINCLLTPVTVEITQNIKTTQVPITDDLPKEPSSSTNSESKKRRTASPPVLPKIKAETESDPATPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPPVGISAAEIPKLGPLCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPGDGKAAWTEAVLSSKKPKLESHSNSPAWSLSGRDERETGSPPGFDEYKVSKEWAASSTFSNVCNQQPLDLSSGMKQKAEGPGKAPVQWEAVLDLSVHKKPCGDSEGKEFKENHVLQPSCSAIKKRKPTTCMLQKVLLNEYNGVDLPVENTPDVSGSASPCKPLDPQPDSDRGLNSSLSAAVVESLPDVSSSSPALQPSSLSCGRLPPLLTPTTPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSGASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPSVEPVMSAASPGPPTLSSSSSSSSSSSFSSSSSSSSPSPPPLSAVSSVVSSGDNLETSLPMISFKQEELESEDLKAREEAPSTTEQEIVQETFNRNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKVKTDLSEHRFMLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLEASKEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRSPLGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKTTPESSSHVCPYCHREFTYIGSLNKHAAFSCPKKPVSPSKKKLSHSSKKGGHPSPAGSDRNNSSSHRRRTADAEIKMQSMQAPLGKTRARSSGPSQVPPPPSSFRSKQNVKFAASVKSKKPSSSLRNSSPIRMAKMTHSETKKPKAAAKNHAAPLSGKMSRSLHVRAQKSRAVLQSKSALASKKRTDRFSVKSRERSGGPITRSLQLAASADPSENRKEDGSGKQELKDLST", "length": 1660, "header": "tr|A0AAA9TUN4-1|A0A3Q1LVN6_BOVIN Computationally mapped isoform of PR domain zinc finger protein 2 OS=Bos taurus OX=9913 GN=PRDM2 PE=4 SV=1 CANONICAL=A0A3Q1LVN6-1" }, "locus": { "chromosome": "16", "start_pos": 53904080, "end_pos": 53790908, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093907.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093907.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101049.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101049.1" } ] } }, { "isoform_ac": "F1N790-1", "url": "https://www.uniprot.org/uniprotkb/F1N790/entry", "sequence": { "sequence": "MWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGKKKSQESKNKANKTEDIQLKTSEPDPSPANMRDSAEGPKDEDENPSASTTEQPAIPQEAVSQDVPPDLALPPPAHEPQTGPDSELEAALCEANEVVEEEEEEEEEELEEEGDEAADVPNESSLRELEIRCDEKPEDLLEEPKTVSKETLADSAEAAPVVKTPRAREEANGDVFETFLFPCQHCERKFTTKQGLERHMHIHMSTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKLEDPAGGKAPSDGAPPQDDAQPPGLGQDGLTLSSEKASQDSVTPSVVEENGEAKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLLEEPQPPAEQAPPTPSVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTSSSTSNCDVIEMESNSADLYGINCLLTPVTVEITQNIKTTQVPITDDLPKEPSSSTNSESKKRRTASPPVLPKIKAETESDPATPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPPVGISAAEIPKLGPLCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPGDGKAAWTEAVLSSKKPKLESHSNSPAWSLSGRDERETGSPPGFDEYKVSKEWAASSTFSNVCNQQPLDLSSGMKQKAEGPGKAPVQWEAVLDLSVHKKPCGDSEGKEFKENHVLQPSCSAIKKRKPTTCMLQKVLLNEYNGVDLPVENTPDVSGSASPCKPLDPQPDSDRGLNSSLSAAVVESLPDVSSSSPALQPSSLSCGRLPPLLTPTTPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSGASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPSVEPVMSAASPGPPTLSSSSSSSSSSSFSSSSSSSSPSPPPLSAVSSVVSSGDNLETSLPMISFKQEELESEDLKAREEAPSTTEQEIVQETFNRNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKVKTDLSEHRFMLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLEASKEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRSPLGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKTTPESSSHVCPYCHREFTYIGSLNKHAAFSCPKKPVSPSKKKLSHSSKKGGHPSPAGSDRNNSSSHRRRTADAEIKMQSMQAPLGKTRARSSGPSQVPPPPSSFRSKQNVKFAASVKSKKPSSSLRNSSPIRMAKMTHSETKKPKAAAKNHAAPLSGKMSRSLHVRAQKSRAVLQSKSALASKKRTDRFSVKSRERSGGPITRSLQLAASADPSENRKEDGSGKQELKDLRRWL", "length": 1588, "header": "tr|F1N790-1|A0A3Q1LVN6_BOVIN Computationally mapped isoform of PR domain zinc finger protein 2 OS=Bos taurus OX=9913 GN=PRDM2 PE=4 SV=4 CANONICAL=A0A3Q1LVN6-1" }, "locus": { "chromosome": "16", "start_pos": 53884807, "end_pos": 53798214, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027387.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027387.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027387.7", "url": "https://www.ensembl.org/id/ENSBTAP00000027387.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 451, "start_aa": "Thr", "end_pos": 451, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr451", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 517, "start_aa": "Thr", "end_pos": 517, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr517", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", 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"3.4.24.-", "type": "synonym", "evidence": [ { "id": "A0A3Q1LVP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Metalloprotease.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7#function" }, { "database": "UniProtKB", "id": "ARBA00002657", "url": "https://www.uniprot.org/uniprotkb/ARBA00002657#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LMLN", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7", "locus": { "chromosome": "1", "start_pos": 70124805, "end_pos": 70172403, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044172", "url": "https://www.ensembl.org/id/ENSBTAG00000044172" } ] } } ], "crossref": [ { "id": "A0A3Q1LVP7", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LVP7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044172", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044172", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVP7", "url": "https://www.orthodb.org/?gene=A0A3Q1LVP7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N725", "url": "https://www.orthodb.org/?gene=F1N725", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10942", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10942", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10942:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10942:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01457", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01457", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LVP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVP7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N725", "url": "https://www.uniprot.org/uniprotkb/F1N725", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N725-1", "url": "https://www.uniprot.org/uniprotkb/F1N725-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVTTLGLKMAAESGRRAVSSDSGLGPSRWHWSGPLWVRGVLLILGGLRASTTSIPVSLRSSPPCRHHVPSDSEVINKVHLKNHVVKRDVNEHLRIKIIYDKSIEELYLINSKMLAEIWGSCQIYSEQMRRWFALSMAIFMFYVIIFRLLPEKRHLVKNKLFPQAVSYLEKTFQVRRPAGTILLSRQCATNQYQYLRKENDHHRCCTEECAEHTKCGPIIVPEEHLQQCRVCCGGKWPCGAVGVPDQEGVRDADFVLYVGALATERCSHENIISYAAYCQQEAKMDRPIAGYANLCPNMISTQPQEFVGMLSTVKHEIIHALGFSAGLFAFYHDKDGNPLTSRFADGLPPFNYSLGLYQWSDKVVRKVERLWDIRDNKRVPHTVNLLVTPRVVDEARKHFNCPILEGMELENQGGMGTELNHWEKRLLENEAMTGSHTQNRVLSRITLALMEDTGWYKANYSMAEKLDWGRGMGCDFVRRSCKFWIDQQRQKRQMLNPYCNTLRSNPLQLTCRQDQRAVAVCNLQKFPKPLPQEYQYFDELTGVPAEDLPYYGGSVEIADYCPFSQEFSWHLSGEYQRSSDCRVLENQPDLFKNYGAEKYGPHSVCLIQKSAFVMEKCERKLSYPDWGSGCYQVSCSPEGLKVWVQDTSYLCSRAGQVLPVSIQMNGWIHDGNLLCPSCWDFCELCPPETDPPAVNLTRALPLDLCSCSSSLVVTLWLLLGNLFPLLAGFLLCVWH", "length": 735, "header": "tr|A0A3Q1LVP7-1|A0A3Q1LVP7_BOVIN Isoform 1 of Leishmanolysin-like peptidase OS=Bos taurus OX=9913 GN=LMLN PE=3 SV=2 CANONICAL=A0A3Q1LVP7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVP7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7/entry", "sequence": { "sequence": "MVTTLGLKMAAESGRRAVSSDSGLGPSRWHWSGPLWVRGVLLILGGLRASTTSIPVSLRSSPPCRHHVPSDSEVINKVHLKNHVVKRDVNEHLRIKIIYDKSIEELYLINSKMLAEIWGSCQIYSEQMRRWFALSMAIFMFYVIIFRLLPEKRHLVKNKLFPQAVSYLEKTFQVRRPAGTILLSRQCATNQYQYLRKENDHHRCCTEECAEHTKCGPIIVPEEHLQQCRVCCGGKWPCGAVGVPDQEGVRDADFVLYVGALATERCSHENIISYAAYCQQEAKMDRPIAGYANLCPNMISTQPQEFVGMLSTVKHEIIHALGFSAGLFAFYHDKDGNPLTSRFADGLPPFNYSLGLYQWSDKVVRKVERLWDIRDNKRVPHTVNLLVTPRVVDEARKHFNCPILEGMELENQGGMGTELNHWEKRLLENEAMTGSHTQNRVLSRITLALMEDTGWYKANYSMAEKLDWGRGMGCDFVRRSCKFWIDQQRQKRQMLNPYCNTLRSNPLQLTCRQDQRAVAVCNLQKFPKPLPQEYQYFDELTGVPAEDLPYYGGSVEIADYCPFSQEFSWHLSGEYQRSSDCRVLENQPDLFKNYGAEKYGPHSVCLIQKSAFVMEKCERKLSYPDWGSGCYQVSCSPEGLKVWVQDTSYLCSRAGQVLPVSIQMNGWIHDGNLLCPSCWDFCELCPPETDPPAVNLTRALPLDLCSCSSSLVVTLWLLLGNLFPLLAGFLLCVWH", "length": 735, "header": "tr|A0A3Q1LVP7-1|A0A3Q1LVP7_BOVIN Isoform 1 of Leishmanolysin-like peptidase OS=Bos taurus OX=9913 GN=LMLN PE=3 SV=2 CANONICAL=A0A3Q1LVP7-1" }, "locus": { "chromosome": "1", "start_pos": 70172204, "end_pos": 70125809, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082149.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082149.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064728.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064728.2" } ] } }, { "isoform_ac": "F1N725-1", "url": "https://www.uniprot.org/uniprotkb/F1N725/entry", "sequence": { "sequence": "MVTTLGLKMAAESGRRAVSSDSGLGPSRWHWSGPLWVRGVLLILGGLRASTTSIPVSLRSSPPCRHHVPSDSEVINKVHLKNHVVKRDVNEHLRIKIIYDKSIEELLPEKRHLVKNKLFPQAVSYLEKTFQVRRPAGTILLSRQCATNQYQYLRKENDHHRCCTEECAEHTKCGPIIVPEEHLQQCRVCCGGKWPCGAVGVPDQEGVRDADFVLYVGALATERCSHENIISYAAYCQQEAKMDRPIAGYANLCPNMISTQPQEFVGMLSTVKHEIIHALGFSAGLFAFYHDKDGNPLTSRFADGLPPFNYSLGLYQWSDKVVRKVERLWDIRDNKRVPHTVNLLVTPRVVNEAMTGSHTQNRVLSRITLALMEDTGWYKANYSMAEKLDWGRGMGCDFVRRSCKFWIDQQRQKRQMLNPYCNTLRSNPLQLTCRQDQRAVAVCNLQKFPKPLPQEYQYFDELTGVPAEDLPYYGGSVEIADYCPFSQEFSWHLSGEYQRSSDCRVLENQPDLFKNYGAEKYGPHSVCLIQKSAFVMEKCERKLSYPDWGSGCYQVSCSPEGLKVWVQDTSYLCSRAGQVLPVSIQMNGWIHDGNLLCPSCWDFCELCPPETDPPAVNLTRALPLDLCSCSSSLVVTLWLLLGNLFPLLAGFLLCVWH", "length": 657, "header": "tr|F1N725-1|A0A3Q1LVP7_BOVIN Computationally mapped isoform of Leishmanolysin-like peptidase OS=Bos taurus OX=9913 GN=LMLN PE=3 SV=4 CANONICAL=A0A3Q1LVP7-1" }, "locus": { "chromosome": "1", "start_pos": 70172204, "end_pos": 70125809, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061181.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061181.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053696.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053696.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7" } ], "pmid": "" }, { "name": "peptidase activity", "id": "GO:0008233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008233", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" }, { "start_pos": 459, "end_pos": 461, "annotation": "n_glycosylation_sequon" }, { "start_pos": 695, "end_pos": 697, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LVP7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 735, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LVP7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LVP7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "PIRSR601577-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601577-2" } ], "binding_site_uniprot": 273, "amino_acid": "Ser", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 273, "end_pos": 273, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR601577-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601577-2" } ], "binding_site_uniprot": 277, "amino_acid": "Tyr", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 277, "end_pos": 277, "start_aa": "Tyr", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LVP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7" }, { "id": "PIRSR601577-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601577-2" } ], "binding_site_uniprot": 315, "amino_acid": "His", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 315, "end_pos": 315, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LVP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7" }, { "id": "PIRSR601577-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601577-2" } ], "binding_site_uniprot": 319, "amino_acid": "His", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 319, "end_pos": 319, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LVP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVP7" }, { "id": "PIRSR601577-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR601577-2" } ], "binding_site_uniprot": 421, "amino_acid": "His", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 421, "end_pos": 421, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 351, "end_pos": 353 }, { "start_pos": 459, "end_pos": 461 }, { "start_pos": 695, "end_pos": 697 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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} ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LVT2-1", "uniprot_ac": "A0A3Q1LVT2", "uniprot_id": "A0A3Q1LVT2_BOVIN", "mass": { "chemical_mass": 21333.0, "monoisotopic_mass": 21333.0 }, "refseq": { "ac": "NP_001300994", "name": "phospholipase A and acyltransferase 1 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300994" }, "gene_names": [ { "name": "PLAAT1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LVT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2" } ] }, { "name": "HRASLS", "type": "synonym", "evidence": [ { "id": "NP_001300994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300994" } ] }, { "name": "PLAAT1", "type": "synonym", "evidence": [ { "id": "NP_001300994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300994" } ] } ], "protein_names": [ { "name": "HRAS like suppressor", "type": "synonym", "evidence": [ { "id": "NP_001300994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300994" } ] }, { "name": "Phospholipase A and acyltransferase 1", "type": "synonym", "evidence": [ { "id": "A0A3Q1LVT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2/entry#names_and_taxonomy" } ] }, { "name": "phospholipase A and acyltransferase 1 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001300994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300994" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLAAT1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2", "locus": { "chromosome": "1", "start_pos": 74163666, "end_pos": 74183415, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000035844", "url": "https://www.ensembl.org/id/ENSBTAG00000035844" } ] } } ], "crossref": [ { "id": "A0A3Q1LVT2", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LVT2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000035844", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000035844", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540539", "url": "https://www.ncbi.nlm.nih.gov/gene/540539", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540539", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540539", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RQRAKYY", "url": "https://omabrowser.org/oma/group/RQRAKYY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVT2", "url": "https://www.orthodb.org/?gene=A0A3Q1LVT2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13943", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13943", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13943:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13943:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04970", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04970", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1482839", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482839", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001300994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300994", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVT2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QAQ8", "url": "https://www.uniprot.org/uniprotkb/F6QAQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QAQ8-1", "url": "https://www.uniprot.org/uniprotkb/F6QAQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGYQTGHSSEPGTCVCLKHRMAFNDCFSLSYPGNPRPGDLIEVFRPCYQHWALYLGDGYVINIAPLEDGISPSFTSAKSLFSRKALVKMQLLKDVVGKDTYRINNKYDDTYPPLPVEEVIQRSEFVIGQEVEYDILVNNCEHFVTLLRYGEGVSEQASRAISTIGFVTAAAGAFSFLGLFPKRLRPKFY", "length": 190, "header": "tr|A0A3Q1LVT2-1|A0A3Q1LVT2_BOVIN Isoform 1 of Phospholipase A and acyltransferase 1 OS=Bos taurus OX=9913 GN=PLAAT1 PE=3 SV=1 CANONICAL=A0A3Q1LVT2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVT2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2/entry", "sequence": { "sequence": "MPGYQTGHSSEPGTCVCLKHRMAFNDCFSLSYPGNPRPGDLIEVFRPCYQHWALYLGDGYVINIAPLEDGISPSFTSAKSLFSRKALVKMQLLKDVVGKDTYRINNKYDDTYPPLPVEEVIQRSEFVIGQEVEYDILVNNCEHFVTLLRYGEGVSEQASRAISTIGFVTAAAGAFSFLGLFPKRLRPKFY", "length": 190, "header": "tr|A0A3Q1LVT2-1|A0A3Q1LVT2_BOVIN Isoform 1 of Phospholipase A and acyltransferase 1 OS=Bos taurus OX=9913 GN=PLAAT1 PE=3 SV=1 CANONICAL=A0A3Q1LVT2-1" }, "locus": { "chromosome": "1", "start_pos": 74175545, "end_pos": 74163817, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073394.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073394.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059453.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059453.1" } ] } }, { "isoform_ac": "A0AAA9SGQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGQ6/entry", "sequence": { "sequence": "MPGYQTGHSSEPGTCVCLKHRMAFNDCFSLSYPGNPRPGDLIEVFRPCYQHWALYLGDGYVINIAPLEDGISPSFTSAKSLFSRKALVKMQLLKDVVGKDTYRINNKYDDTYPPLPVEEVIQRSEFVIGQEVEYDILVNNCEHFVTLLRYGEGVSEQVVALGRGTTFPSLLYKFIFLW", "length": 178, "header": "tr|A0AAA9SGQ6-1|A0A3Q1LVT2_BOVIN Computationally mapped isoform of Phospholipase A and acyltransferase 1 OS=Bos taurus OX=9913 GN=PLAAT1 PE=3 SV=1 CANONICAL=A0A3Q1LVT2-1" }, "locus": { "chromosome": "1", "start_pos": 74175545, "end_pos": 74167471, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093025.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093025.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085370.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085370.1" } ] } }, { "isoform_ac": "F6QAQ8-1", "url": "https://www.uniprot.org/uniprotkb/F6QAQ8/entry", "sequence": { "sequence": "MPGYQTGHSSEPGTCVCLKHRMAFNDCFSLSYPGNPRPGDLIEVFRPCYQHWALYLGDGYVINIAPLEDGISPSFTSAKSLFSRKALVKMQLLKDVVGKDTYRINNKYDDTYPPLPVEEVIQRSEFVIGQEVEYDILVNNCEHFVTLLRYGEGVSEQVSFL", "length": 161, "header": "tr|F6QAQ8-1|A0A3Q1LVT2_BOVIN Computationally mapped isoform of Phospholipase A and acyltransferase 1 OS=Bos taurus OX=9913 GN=PLAAT1 PE=3 SV=3 CANONICAL=A0A3Q1LVT2-1" }, "locus": { "chromosome": "1", "start_pos": 74175545, "end_pos": 74168638, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050331.5", "url": "https://www.ensembl.org/id/ENSBTAT00000050331.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047043.5", "url": "https://www.ensembl.org/id/ENSBTAP00000047043.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540539", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540539", "resource": "KEGG Pathway" }, { "id": "R-BTA-1482839", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482839", "resource": "Reactome", "description": "Acyl chain remodelling of PE" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IY06-1", "protein_name": "Phospholipase A and acyltransferase 1", "gene_name": "plaat1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDNQQRRTDNMASGETDHLQCVEEPQPGDLIEIFRPAYQHWALYLGDGYIINLTPVDEGQATAVSSVKSVFSRKAVVRMQLLKEVVGADSYRINNKYDDDHTPLPVSEIIQRAQMLIGQEVSYDLLGSNCEHFVTLLRYGEGVSEQASRAIGAISLVTAAASAFSVLGLINTRSRNRPF", "length": 179 }, "evidence": [ { "id": "A0A3Q1LVT2", "url": "https://omabrowser.org/oma/group/A0A3Q1LVT2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A286ZPI9-1", "protein_name": "Phospholipase A and acyltransferase 1", "gene_name": "PLAAT1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAFNDCFSLNYPGNPRPGDLIEVFRPGYQHWALYLGDGYVINIAPLEDGISTSFTSAKSIFSTKALVKMQLLKDVVGNDTFRINNKYDDTYAPLPVEEVMQRSEFVIGQEVEYDIFVNNCEHFVTLLRYGAGISEQANRAISTIGFVTAAAGAFSFLGLFPKRLRAKYY", "length": 169 }, "evidence": [ { "id": "A0A3Q1LVT2", "url": "https://omabrowser.org/oma/group/A0A3Q1LVT2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D2KX21-1", "protein_name": "Phospholipase A and acyltransferase 1", "gene_name": "Plaat1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAVNDCFSLTYPHNPHPGDLIEVFRPCYQHWALYLGDGYVINIAPVDGIPSSFSSAKSVFSTKALVKMQLLKDVVGNDTYRINNKYDTTYPPLPVEEVIQRSEFAIGQEVTYDLLVNNCEHFVTLLRYGEGVSEQANRAIGTIGLVAAGIDIFTFLGLFPKRQGAKS", "length": 167 }, "evidence": [ { "id": "A0A3Q1LVT2", "url": "https://omabrowser.org/oma/group/A0A3Q1LVT2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1C3C1-1", "protein_name": "Phospholipase A and acyltransferase 1", "gene_name": "HRASLS", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAANESFSAAHPGDPQPGDLIEIFRPAYQHWALYLGDGYIINVTPVEEGPPATFGSAKSVFSRKAMVRMQLLKEVVGNDTYRINNKYDGTYAPLPVEEIIRRAEYLINQEVSYDLLGNNCEHFVTLLRYGEGVSEQANRAISAIGFVTAAAGAFSLLGLLRSRSRERQY", "length": 169 }, "evidence": [ { "id": "A0A3Q1LVT2", "url": "https://omabrowser.org/oma/group/A0A3Q1LVT2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3I4Z2-1", "protein_name": "Phospholipase A and acyltransferase 1", "gene_name": "Plaat1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAFNDCFSLADPHNPRPGDLIEVFRPGYQHWALYLGDGYVINLTPIDGVPSPFTSAKSMFSTKALVKMQLLKDVVGNDTYRINNKYDTTYPPLPVDEVIQRSEFAIGQEVAYDLLVNNCEHFVTLLRYGEGVSDQANRAISTIGVVAAAIDIFTFLGLFPKRQRTKY", "length": 167 }, "evidence": [ { "id": "A0A3Q1LVT2", "url": "https://omabrowser.org/oma/group/A0A3Q1LVT2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9HDD0-1", "protein_name": "Phospholipase A and acyltransferase 1", "gene_name": "PLAAT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAFNDCFSLNYPGNPCPGDLIEVFRPGYQHWALYLGDGYVINIAPVDGIPASFTSAKSVFSSKALVKMQLLKDVVGNDTYRINNKYDETYPPLPVEEIIKRSEFVIGQEVAYNLLVNNCEHFVTLLRYGEGVSEQANRAISTVEFVTAAVGVFSFLGLFPKGQRAKYY", "length": 168 }, "evidence": [ { "id": "A0A3Q1LVT2", "url": "https://omabrowser.org/oma/group/A0A3Q1LVT2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QZU4-1", "protein_name": "Phospholipase A and acyltransferase 1", "gene_name": "Plaat1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVNDCFSLTYPHNPHPGDLIEVFRPCYQHWALYLGDGYVINIAPIDGIRSSFTSAKSVFSTKALVKMQLLKDVVGNDTYRINNKYDTTYPPLPVEEVIQRSEFPIGQEVAYDLLVNNCEHFVTLLRYGEGVSEQANRAIGTIGLVAAGIDIFTFLGLFPKRQRTKY", "length": 167 }, "evidence": [ { "id": "A0A3Q1LVT2", "url": "https://omabrowser.org/oma/group/A0A3Q1LVT2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "phospholipase A2 activity", "id": "GO:0004623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004623", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2" } ], "pmid": "" }, { "name": "phospholipase A1 activity", "id": "GO:0008970", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008970", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2" } ], "pmid": "" }, { "name": "N-acyltransferase activity", "id": "GO:0016410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016410", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2" } ], "pmid": "" }, { "name": "O-acyltransferase activity", "id": "GO:0008374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008374", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2" } ], "pmid": "" }, { "name": "transferase activity", "id": "GO:0016740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "phosphatidylcholine metabolic process", "id": "GO:0046470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046470", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2" } ], "pmid": "" }, { "name": "N-acylphosphatidylethanolamine metabolic process", "id": "GO:0070292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070292", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2" } ], "pmid": "" }, { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LVT2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 190, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LVT2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LVT2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LVT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT2" }, { "id": "PS51934", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51934" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRAT", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 157, "start_aa": "Leu", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LVT3-1", "uniprot_ac": "A0A3Q1LVT3", "uniprot_id": "A0A3Q1LVT3_BOVIN", "mass": { "chemical_mass": 53835.0, "monoisotopic_mass": 53835.0 }, "refseq": { "ac": "XP_005225324", "name": "E3 ubiquitin-protein ligase TRIM4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225324" }, "gene_names": [ { "name": "TRIM4", "type": "recommended", "evidence": [ { "id": "A0A3Q1LVT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT3" } ] }, { "name": "TRIM4", "type": "synonym", "evidence": [ { "id": "XP_005225324", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225324" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase TRIM4", "type": "synonym", "evidence": [ { "id": "XP_005225324", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225324" } ] }, { "name": "Tripartite motif containing 4", "type": "synonym", "evidence": [ { "id": "A0A3Q1LVT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVT3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRIM4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT3", "locus": { "chromosome": "25", "start_pos": 36489028, "end_pos": 36470685, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050135", "url": "https://www.ensembl.org/id/ENSBTAG00000050135" } ] } } ], "crossref": [ { "id": "A0A3Q1LVT3", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LVT3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050135", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050135", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15809", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15809", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "527577", "url": "https://www.ncbi.nlm.nih.gov/gene/527577", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035829", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035829", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527577", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527577", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NAVDGEH", "url": "https://omabrowser.org/oma/group/NAVDGEH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVT3", "url": "https://www.orthodb.org/?gene=A0A3Q1LVT3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15227", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15227", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005225324", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225324", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVT3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVT3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAEDFQEELTCAICLDYFEDPVSIECGHNFCRGCLCRTWAPGGSPVRCPECRRPSAPASMRPNWALARLTERMRRRRLGPVPAGLCGRHWEPLRLFCEDDQRLVCLVCRESQEHQAHTMSPADEACRSYREKLLKTQSSLTAKMKKVIHFQDTEVKNAAEWKEKMKNQRMRVIAEFAKLHVLLNEEEQLFLQGLRQEEEETKKKQSENISRLNQMITSLKKLILEVKEKSQSSTLELLQNPAEVLTRCENQDVNYSFEDLTVKTVCRLPMMKEMLKRFQVAVNLAEDTAHSKLVFSQEGRYVKNGASASSWPLFFTAWSYATGWRNPQRTTGFVERFQHLPCVLGKNVFTSGKHYWEVENRGSLEVAAGVCREDIMGIPGGSTMCPKAGIWAVGWSSAGFWPLTGTSVSPTKREPALQRVGVFLDHGAGEVSFYNAVDGEHLHTLPCSSSLRLRPFFWLSPLASVVIPPVTGGK", "length": 475, "header": "tr|A0A3Q1LVT3-1|A0A3Q1LVT3_BOVIN Isoform 1 of Tripartite motif containing 4 OS=Bos taurus OX=9913 GN=TRIM4 PE=4 SV=1 CANONICAL=A0A3Q1LVT3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVT3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVT3/entry", "sequence": { "sequence": "MEAEDFQEELTCAICLDYFEDPVSIECGHNFCRGCLCRTWAPGGSPVRCPECRRPSAPASMRPNWALARLTERMRRRRLGPVPAGLCGRHWEPLRLFCEDDQRLVCLVCRESQEHQAHTMSPADEACRSYREKLLKTQSSLTAKMKKVIHFQDTEVKNAAEWKEKMKNQRMRVIAEFAKLHVLLNEEEQLFLQGLRQEEEETKKKQSENISRLNQMITSLKKLILEVKEKSQSSTLELLQNPAEVLTRCENQDVNYSFEDLTVKTVCRLPMMKEMLKRFQVAVNLAEDTAHSKLVFSQEGRYVKNGASASSWPLFFTAWSYATGWRNPQRTTGFVERFQHLPCVLGKNVFTSGKHYWEVENRGSLEVAAGVCREDIMGIPGGSTMCPKAGIWAVGWSSAGFWPLTGTSVSPTKREPALQRVGVFLDHGAGEVSFYNAVDGEHLHTLPCSSSLRLRPFFWLSPLASVVIPPVTGGK", "length": 475, "header": "tr|A0A3Q1LVT3-1|A0A3Q1LVT3_BOVIN Isoform 1 of Tripartite motif containing 4 OS=Bos taurus OX=9913 GN=TRIM4 PE=4 SV=1 CANONICAL=A0A3Q1LVT3-1" }, "locus": { "chromosome": "25", "start_pos": 36488024, "end_pos": 36470884, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085628.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085628.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061537.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061537.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527577", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527577", "resource": "KEGG Pathway" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RNQ5-1", "protein_name": "Tripartite motif containing 4", "gene_name": "TRIM4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALRPSAGGGGRRSEGHRLRGPACSLPAFPPTPPPDRGQRSSMEAEDLQEELSCSICLDYFEDPVSIECGHNFCRDCLRRGLAQGCNQFPCPECRRPSTPSALRPNWALARLAQKARRRREGPASRGLCDRHGEPLRLFCEDDQRLMCMVCRESQEHQAHTMAPMDEAFQSYRGKLLEAQCHLTAKLEKAIGLQDLEMKNTAEWKEKMKNQRLRLSAEFAKLRLFLTEEEQLFLQRLSQEEEETKKKQREKTLRLSQMVSALKQLISEVKEKSQSPELELLQNPKDVLTRCENQDVNYSLEVLHVKTVCQLPMVKELLKRFQVPVNPALDTAHPKLVFSQEGRYMKNGAAAAGSWPLTTAWSYLAGWRSHQKTAGFVERFRHLPCVLGQNVFTLGKYYWEVENRGDLEVAVGVCREDVMEVTEDSEMSPFVGIWAICWSSAGFRPLTRPPASPTKREPALHGVGIFLDQGAGEVSFYSAAEGEHLHTFSCPVSNLRPFFWLSPLASLFIPPVTGGK", "length": 516 }, "evidence": [ { "id": "A0A3Q1LVT3", "url": "https://omabrowser.org/oma/group/A0A3Q1LVT3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9C037-1", "protein_name": "E3 ubiquitin-protein ligase TRIM4", "gene_name": "TRIM4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193070", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "36683", "url": "https://www.rhea-db.org/rhea/36683", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LVW6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVW6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGPGLGSQCRNHSHGPYPPGFGRHGVCAHENKELAKAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQYGADPALIDGEGFCGIHLAVLFQHMPIIAYLISKGQSVNTIDVNGQTPLMLSANKVLGPEPTGFLLKFNPSLNIVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDVRNVKGETPLDMALQNKNRLIIHMLKTEAKTRANKNFRLWRWLQKCEVFLLLLLSVITMWAVGYILDFDSDSWLLKGFLLIILFFLTSLFPRFLLGYKSLIYLPTVFLLSSIFWMFMTWFILFFPDVAGTPLYFVFIISIAAFLYFFYKTWTTDPGFTKASEEEKKMSIITLAETGCLDFRTFCTSCLIRKPLRSLHCHVCNSCVARYDQHCMWTGRCIGFGNHHYYIFFLFFLSIVCDWFIYESFIYWSNHCTTTFKEDGLWTYLNQAVTCSPWVMYIFVLASFHFSWSAFLLINQLFQIAFLGLTSYERTSLLKQSKHMKQTLSLRRTPYNLGFTQNLADFFQCGCFGLVKPCAVDWTSQYTMVFHPAKEKVLRSV", "length": 622, "header": "tr|A0A3Q1LVW6-1|A0A3Q1LVW6_BOVIN Isoform 1 of Palmitoyltransferase OS=Bos taurus OX=9913 GN=ZDHHC13 PE=3 SV=1 CANONICAL=A0A3Q1LVW6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVW6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6/entry", "sequence": { "sequence": "MEGPGLGSQCRNHSHGPYPPGFGRHGVCAHENKELAKAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQYGADPALIDGEGFCGIHLAVLFQHMPIIAYLISKGQSVNTIDVNGQTPLMLSANKVLGPEPTGFLLKFNPSLNIVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDVRNVKGETPLDMALQNKNRLIIHMLKTEAKTRANKNFRLWRWLQKCEVFLLLLLSVITMWAVGYILDFDSDSWLLKGFLLIILFFLTSLFPRFLLGYKSLIYLPTVFLLSSIFWMFMTWFILFFPDVAGTPLYFVFIISIAAFLYFFYKTWTTDPGFTKASEEEKKMSIITLAETGCLDFRTFCTSCLIRKPLRSLHCHVCNSCVARYDQHCMWTGRCIGFGNHHYYIFFLFFLSIVCDWFIYESFIYWSNHCTTTFKEDGLWTYLNQAVTCSPWVMYIFVLASFHFSWSAFLLINQLFQIAFLGLTSYERTSLLKQSKHMKQTLSLRRTPYNLGFTQNLADFFQCGCFGLVKPCAVDWTSQYTMVFHPAKEKVLRSV", "length": 622, "header": "tr|A0A3Q1LVW6-1|A0A3Q1LVW6_BOVIN Isoform 1 of Palmitoyltransferase OS=Bos taurus OX=9913 GN=ZDHHC13 PE=3 SV=1 CANONICAL=A0A3Q1LVW6-1" }, "locus": { "chromosome": "29", "start_pos": 25825068, "end_pos": 25774529, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067602.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067602.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059499.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059499.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:514176", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514176", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IQZ2-1", "protein_name": "Putative palmitoyltransferase ZDHHC13", "gene_name": "zdhhc13", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDWSEGDGSHSHGHMGDSCHGHGGGHSHGHGHSHGGSGFGGFMPAGFHGQLVPGPMDPTQQPRKSSHPEDSSSWDIIKATQFGALERCKELVEAGYDVRQPDKENVTLLHWAAINNRADIVKYYISKGAVIDQLGGDLNSTPLHWAIRQGHLSMVIQLMRYGADPSLADGEGYRGLHLAVLFQNMPIAAYLMAKGQEVDLPDLNGQTPLMLAAQKIIGPEPTNFLIKCNASVNAVDKVNRNSPLHCAVLAGNVDSVHILLEAGASVDMQNDNGHTAIDLAQQVHSPLLIHMLSVVKTERIKANSACLKLLNRYKVCLQSVFSVVVVGAFGAILDMRTESWLLKGILLACIMAVINLASRQLATVAVRSLIPSTGLIASVFWMVVTWVLWFLPDEPSAAVQMLFTVNITAVLYYYIRSCRTDPGHVKATEEEKKKNIVVLAEAGCLDPRIFCTSCMMRKPMRANHCFSCNACVAKQDHHSIWINGCIGARNHPFFVLFLVALNFLCIWMFYGSITYWSRHCPLHYSEEGIWGALTALMGCSPWLLYVFCFVFFHTTWASILLVLQLYQIAFLGLTTSERANLMHRQRKLPQAVSLRQNPFNHGVVKNLVNFFQWRFCGLCKPMVLDWTQQHPMGLGRDMFSSPDAV", "length": 645 }, "evidence": [ { "id": "A0A3Q1LVW6", "url": "https://omabrowser.org/oma/group/A0A3Q1LVW6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A480HRH1-1", "protein_name": "Palmitoyltransferase", "gene_name": "ZDHHC13", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGPGLGSQCRNHSHGPYPPGFGRHGVCAHEKQLAKAREGLPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQYGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVDGHTPLMLSAHKVLGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVSAVDKLLEAGASLDIRNVKGETPFDMALQNKNRLIIHMLKTEAKMRANKNFRLWRWLQKCELFLLLMLSVITMWAVGYILDFNSDSWLLKGSLLITLFFLTSLFPRFLVGYKSLIYLPTVFLLSSIFWIFMTWFMLFFPDLAGTPFYFIFILSILAFLYFFYKTWATDPGFTKASEEEKKMNIITLAETGSLDLRTFCTSCLIRKPLRSLHCHVCNSCVARYDQHCLWTGRCVGFGNHHYYIFFLFFLSIVCEWIMYESFIYWSNHCATTFKEDGLWTYLNQIVACSPWVLYIFVLASFHFSWSMFLLLNQLFQIAFLGLTSYEKTSLLKQSRHMKQTLSLRRTPYNLGFTQNLADFFQCGCFGLAKPCAVDWTSQYTMVSHPAKEKVLRSV", "length": 621 }, "evidence": [ { "id": "A0A3Q1LVW6", "url": "https://omabrowser.org/oma/group/A0A3Q1LVW6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZFK7-1", "protein_name": "Palmitoyltransferase", "gene_name": "ZDHHC13", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MCKNHCHGPHRSHMHSCHSICRERDVPVLPGPHPVAEDPGTCDIVKATQYGMLERCKELVEAGYDVRQPDKENVTLLHWAAINNRQELVKYYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLKCGADPSLIDGEGFSSIHLAVLFQHVPIVAYLISKGQNIDTADFNGLTPLMLSAQKVVGPEPTRFLLKFNPSLNAVDNVQKNTALHWAVTSGNVSAVELLLEAGANMDIKNVKGETALDLAIQTQNRFMIYMLMEEARMRSRRNNRLLRIMEKYELSLLLASCLTLLWAIGYIMNLSSDSWLLKGCLLLFLLAGMALLVRQFVGLKNLRYLPTALMLSSVFWMSVTWLFWFMPDVTNTIFEIPVMFSIVGLLYFFYKTWRTDPGYVKSSEKDKKENIVALAEAGCLDFRTFCTSCLVRKPLRSVHCLLCDSCVARYDQHSLWIAQCIGVGNHHYYLLFLSFLTVTSVWLLYRSLLYWSNHCVTSYHADGAWTYFTQITSCSPWVSYIFMLACFHTVWASLWLTTQLYQIAFLGLTSHERMSLLMESKSSKHPVSLRRNPYNLGCFQNLADFFQCRCFGMVKPNGVDWTKQYNVHMIKKNVYSV", "length": 610 }, "evidence": [ { "id": "A0A3Q1LVW6", "url": "https://omabrowser.org/oma/group/A0A3Q1LVW6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E9PU37-1", "protein_name": "Palmitoyltransferase", "gene_name": "Zdhhc13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGPGLGSQCRNHSHGSHVPGFGQHGICAHENKELAKAKEILPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDRENVSLLHWAAINNRLELVKFYISKGAVIDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAYKVIGPEPTGFLLKFNPSLSAVDKTHQNTPLHWAVAAGNVSAVDKLLEAGSSLDLRNAKGETPLDMAVQNKNQLIVHMLRTEAKMRANKKFRLWQWLHKCELFLLLVLSMISLWAVGYILNFNSDSWLLKGCLLVALLFLTSLFPRFLVGYKNLVYLPTVFLLSSIFWIFMTWFILFFPDAAGSPFYFAFIFSIMAFLYFFYKTWATDPGFTKASEEERKVNIVTLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNSCVARFDQHCFWTGRCIGFGNHHHYIFFLLSLSMVCDWIIYGSFVYWSNHCATTFKEDGLWTYLNQIVACSPWVLYIFMLAAFHFSWSTFLLINQLFQIAFLGLTSHERISLLKQSRHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCIIDWTSQYTMVFHPAKEKVLRSV", "length": 622 }, "evidence": [ { "id": "A0A3Q1LVW6", "url": "https://omabrowser.org/oma/group/A0A3Q1LVW6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q52T38-1", "protein_name": "Protein S-acyltransferase 24", "gene_name": "PAT24", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSSEIEVVEEIQSNPKENGESSSKGIEEESLKNDVYTAAAYGDLEKLHRLVECEGSSVSEPDALGYYALQWSALNNRVAVAQYLIEHGGDVNATDHTGQTALHWSAVRGAIQVAELLLQEGARVDATDMYGYQATHVAAQYGQTAFLCHVVSKWNADPDVPDNDGRSPLHWAAYKGFADSIRLLLFLDAYRGRQDKEGCTPLHWAAIRGNLEACTVLVQAGKKEDLMITDKTGLTPAQLAAEKNHRQVSFFLGNARSLLEKRCDGSSPLGRLSKLGLAPVLWIMILLLLLVYTNSVVLASNLPKLTTGIGALAWLGFILATAGLFLFYRCSRKDPGYIRMNIHDPQTMKDDEPLLKIELNNPALLAGNWTQLCATCKIIRPLRAKHCSTCDRCVEQFDHHCPWVSNCVGKKNKWEFFLFLLLEVLAMLITGGVTLARVLSDPSAPSSFGAWMSHVASNHVGALSFLLVEFCLFFSVAVLTVIQASQISRNITTNEMANALRYSYLRGPGGRFRNPYDLGCRRNCSDFLVKGYNEDIECHEEDATQRPEGISMMQMQRNPNLQNGNGHVAIDVNPTHNSQSAHVHSANCSHSHNSKSKSDNVPLGLGLGLSRNPTRPVVSP", "length": 620 }, "evidence": [ { "id": "A0A3Q1LVW6", "url": "https://omabrowser.org/oma/group/A0A3Q1LVW6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8IUH4-1", "protein_name": "Palmitoyltransferase ZDHHC13", "gene_name": "ZDHHC13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGPGLGSQCRNHSHGPHPPGFGRYGICAHENKELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLWRWLQKCELFLLLMLSVITMWAIGYILDFNSDSWLLKGCLLVTLFFLTSLFPRFLVGYKNLVYLPTAFLLSSVFWIFMTWFILFFPDLAGAPFYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSFIYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLLNQLFQIAFLGLTSHERISLQKQSKHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCVVDWTSQYTMVFHPAREKVLRSV", "length": 622 }, "evidence": [ { "id": "A0A3Q1LVW6", "url": "https://omabrowser.org/oma/group/A0A3Q1LVW6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CWU2-1", "protein_name": "Palmitoyltransferase ZDHHC13", "gene_name": "Zdhhc13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGPGLGSQCRNHSHGSHVPGFGRHGICVHENKELAKAKEILPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDRENVSLLHWAAINNRLELVKFYISKGAVIDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAYKVIGPEPTGFLLKFNPSLSVVDKTHQNTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKNQLISHMLRTEAKMRANKQFRLWRWLHKCELFLLLILSMITLWAVGYILDFNSDSWLLKGCLLVALFFLTSLFPRFLVGYKNLVYLPTVFLLSSIFWIFMTWFILFFPDTAGSPLYFAFIFSIMAFLYFFYKTWATDPGFTKASEEERKVNIVTLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNSCVARFDQHCFWTGRCIGFGNHHHYIFFLLSLSMVCDWIIYGSFVYWSNHCATTFKEDGLWTYLNQIVACSPWVLYIFMLAAFHFSWSTFLLINQLFQIAFLGLTSHERISLLKQSRHMKQTLSLRKTPYNLGFTQNLADFFQCGCFGLVKPCIIDWTSQYTMVFHPAKEKVLRSV", "length": 622 }, "evidence": [ { "id": "A0A3Q1LVW6", "url": "https://omabrowser.org/oma/group/A0A3Q1LVW6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVW6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVW6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ], "pmid": "" }, { "name": "Golgi-associated vesicle membrane", "id": "GO:0030660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030660", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVW6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-cysteine S-palmitoyltransferase activity", "id": "GO:0019706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019706", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVW6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ], "pmid": "" }, { "name": "magnesium ion transmembrane transporter activity", "id": "GO:0015095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015095", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVW6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36683", "name": "", "equation": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3X756-1", "E1BPA5-1", "F1MVC6-1", "E1B987-1", "E1BJK1-1", "F6R785-1", "A0AAA9TDW4-1", "A0AAA9TVJ9-1", "A0AAA9TM40-1", "E1B6X9-1", "E1BKA0-1", "E1BK60-1", "Q58CU4-1", "A2VDT6-1", "A0AAF6ZH94-1", "A0AAA9RZ07-1", "Q0VC89-1", "E1BLT8-1", "G3MXF3-1", "P15103-1", "Q2HJ95-1", "Q58DA8-1", "A0A3Q1M794-1", "A0A3Q1LVW6-1", "Q58DT3-1", "A0A3Q1M403-1", "A0ABI0NXA5-1" ], "evidence": [ { "id": "36683", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36683" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LVW6", "gene_name": "ZDHHC13", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1LVW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1LVW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ] } ] }, { "uniprot_ac": "A0A3Q1M403", "gene_name": "", "activity": [ { "ec_number": "6.3.1.2", "activity": "L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "6.3.1.2", "activity": "", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] } ] }, { "uniprot_ac": "A0A3Q1M794", "gene_name": "ZDHHC3", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1M794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M794" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1M794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M794" } ] } ] }, { "uniprot_ac": "A0AAA9RZ07", "gene_name": "ZDHHC8", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9RZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ07" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9RZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ07" } ] } ] }, { "uniprot_ac": "A0AAA9TDW4", "gene_name": "ZDHHC7", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW4" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW4" } ] } ] }, { "uniprot_ac": "A0AAA9TM40", "gene_name": "ZDHHC18", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TM40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM40" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TM40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM40" } ] } ] }, { "uniprot_ac": "A0AAA9TVJ9", "gene_name": "ZDHHC23", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TVJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVJ9" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TVJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVJ9" } ] } ] }, { "uniprot_ac": "A0AAF6ZH94", "gene_name": "ZDHHC9", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAF6ZH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAF6ZH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ] } ] }, { "uniprot_ac": "A0ABI0NXA5", "gene_name": "ZDHHC15", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0ABI0NXA5", "database": "UniProtKB", "url": 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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"strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057253", "url": "https://www.ensembl.org/id/ENSBTAG00000057253" } ] } } ], "crossref": [ { "id": "A0A3Q1LVY0", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LVY0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000048465", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048465", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15405", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15405", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "788573", "url": "https://www.ncbi.nlm.nih.gov/gene/788573", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788573", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788573", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NGAMSPK", "url": "https://omabrowser.org/oma/group/NGAMSPK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVY0", "url": "https://www.orthodb.org/?gene=A0A3Q1LVY0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193697", "url": 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}, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LW75-1", "uniprot_ac": "A0A3Q1LW75", "uniprot_id": "A0A3Q1LW75_BOVIN", "mass": { "chemical_mass": 475686.0, "monoisotopic_mass": 475686.0 }, "refseq": { "ac": "XP_024855197", "name": "dynein axonemal heavy chain 6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855197" }, "gene_names": [ { "name": "DNAH6", "type": "recommended", "evidence": [ { "id": "A0A3Q1LW75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75" } ] }, { "name": "DNAH6", "type": "synonym", "evidence": [ { "id": "XP_024855197", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855197" } ] } ], "protein_names": [ { "name": "Dynein axonemal heavy chain 6", "type": "synonym", "evidence": [ { "id": "A0A3Q1LW75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75/entry#names_and_taxonomy" } ] }, { "name": "dynein axonemal heavy chain 6", "type": "synonym", "evidence": [ { "id": "XP_024855197", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855197" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LW75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DNAH6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75", "locus": { "chromosome": "11", "start_pos": 50204036, "end_pos": 50483750, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000049566", "url": "https://www.ensembl.org/id/ENSBTAG00000049566" } ] } } ], "crossref": [ { "id": "ENSBTAG00000049566", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049566", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00009", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00009", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "112448797", "url": "https://www.ncbi.nlm.nih.gov/gene/112448797", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9FQR", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=9FQR&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013602", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013602", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024743", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024743", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026983", "database": "InterPro", "categories": [ "Protein 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"database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17857", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17857", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18198", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18198", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18199", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18199", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024855197", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855197", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LW75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LW75-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASRLSENELDLKSIGELSENPMLARLNSIRAKGRLSFVTPTENQGDTQVLTFEHTTKAQERTRKRQQPKKLEPLPVLKVHQDHKMPDYIYEQNRNRLIASGVLKPPRSPEEKTSTKSLVQFLEHGEAVKKKKQTQWPSADLSPSPAKLSRTGGTGRRGLYETSSLTYPKYYFHDREEVIKANIRDPLQIVKIIRENEHIGFLYMISAVPRSSIEYDTYNLKVVNYENINKNDYYTISKKAVTHVYNNDIEFIEIDRWEQEYLYHRELTKIPIFSLFRKWKAFNVWKKNVRSKKISGCRKSLQKDLFIVNHYLRPALLKINELCYQLSFMGLCSIEKYHTYTLQEFKAAQIVRVGEVTERLEEFRNEAKDVVRKACRVALRAAGFIPDDCARESSEGHFKMPESGSFIELPTGDAEKMTYTEQASKRHHCMRLTCFIRLNDYLIENTMHVLTVNSASSLLNYLTDKLKRTPSADIIQKWITEEKPEVTDKKGAPVLEKQEEDESLVPMFLTELILTVQSLLFEPSLEDFLDGISGAINHFQNTVLSVPNLVPDSYFDAFTSPYINNKMEEKTCGFGPSLSAVFDDDKNFHTIIFQIKEAIQAAFESAQFYAATFEKFQIFFKENESLDLQDLKLQEPGVKFFSEQLEKYHRQHKDAVALRPTRNVGLLLIDTKQLKEKLIPSPLRCLEVLNYMLPRLSKKKVDAIISEAQDAEYKLEFVPTTTIEYVNSLVFLDEIQERIESLEDEGNVVVQMYKLIEQYQVPTPPEDFAVFATMKPSIVAVRNAIDKSVGDRETSIKQFCLHLGRDLEDLSNEVNEVKMLAQDPQILDINADQEKIKVMLNELLLVLDDLQKRAFQYKSYQKNFKVEVSKFDALEEVSAELKLKQLLWDSLSEWDQLQQEWLKSKFDSLDPELLNSQVSKYAKFVTQLEKGLPPNSVVPQLKSKVEKMKEKLPVIIDLRNPTLKPRHWAAIEQTVDATLVDLEVPLTLEKLAELHVFDFGQEIQDISGQASGEAALETILKKVEDSWKTTEFVVLPHRDSKDVFILGGTDDIQVLLDDSTINIATIASSRYVGPLKARVDEWQKQLALFNQTLEEWLNCQRNWLYLESIFNAPDIQRQLPAEAKMFLQVDKSWKEIMRKVNRLPNALRAATQPGLLETFQNNNALLDQIQKCLEAYLESKRVIFPRFYFLSNDELLEILAQTRNPQAVQPHLRKCFDSISKLEFALLPPTEGKIPGMDAEPEKVYTNDILAMLSPEGERVSLGKGLKARGNVEEWLGKVEEAMFTSLRRLCKAAIADYLGKQRTMWVVAGHPSQVILTVSQIMWCRDLTECLEKEEGNHLEALEDFEKVNFERLNALAAIVRGILPKLHRNIITALITIDVHARDIVTELVQAKVQVVDSFDWQRQLRYYWDVDLDNCVARMALSQYTYGYEYLGACPRLVITPLTDRCYLCLMGALQLDLGGAPAGPAGTGKTETTKDLAKALAIQCVVFNCSDGLDYKMMGRFFSGLAQSGAWCCFDEFNRIDIEVLSVIAQQLITIRNAKAAKLSRFMFEGREIKLVMTCAAFITMNPGYAGRTELPDNLKALFRPFAMMVPNYALIAEVILYSEGFESSKILARKMTQMYKLCSEQLSQQDHYDFGMRAVKSVLVMAGSLKRENPDLSEDVVLIRALRDSNLPKFLTDDAILFSGIISDLFPGVQIPEHDYGILQSTIIDVMKKKNLQPEACMVKKVIQFYETMLVRHGVMLVGPTGGGKTTVYQVLAETLGNLQKLGVDNPFYQPVKTYVLNPKSITMGELYGEVNNITLEWKDGLMALSVRAAVNDTSEDHKWIISDGPVDALWIENMNTVLDDNKMLCLANSERIKLTPQIHMLFEVQDLKVASPATVSRCGMVFVDPEELKWMPYVKTWMQSVSKKLSEETQEYILNLFQRYVDDGLNFINKKCHQAIPQVDISKVTTLCCLLESLILEKDGANLTMEQTKLNTVLCQTFVFCYLWSLGGNLTENHWDSFDTFIRTQFDDNPDARLPSSGDLWSIHMDFDTKRLDPWERIIPTFKYSRDTPFFEMLVPTADTVRFGYLMEKLLAVKHSVLFTGITGVGKSVIAKGLLNRIQESAGYVPVYLNFSAQTSSSRTQEIIESKLERKRKNILGAPGNKRVVIFVDDLNMPRLDRYGSQPPIELLRQYQDFGGFYDRNKLFWKDIQDVTIVSACAPPGGGRNPVTPRFIRHFSMLCLPMPSEHSLKQIFQAILNGFLNDFTPAVKQTASNIVEASVEIYNRMSVDLLPTPAKSHYVFNLRDLSKCVQGILQCDPGTIREEIQIFRLFCHECQRVFHDRLINNEDKHYFHAILTEMANKHFGIAIGLEYFLTRPIIFGDFIKFGADRSDRIYDDMPDMEKIANVLQDYLDDYNLINPKEVKLVFFQDAIEHVSRIARMIRQERGNALLVGVGGTGKQSLTRLAAHICGYRCLQIELSRGYNYDSFHEDLRKLYKLAGVEDRNMVFLFTDTQIVVEEFLEDINNILNSGEVPNLFEKDELEQVLAATRPRAKEVGISEGNRDEVFQYFISRVRQKLHIVLCMSPVGEAFRSRCRMFPSLVNCCTIDWFVQWPREALLSVSKTFFSNVDAVNEELREKLSLMCVNVHLSVSNMAERYYTELRRRYYTTPTSYLELINLYLSMLTEKRKQLVSARERVKNGLTKLLETNVLVDKMKLDLSALEPVLLTKSQDVEALMDKLAVDQENADQVRSVVQEDEAIAKVKAEETQAIADDAQRDLEEALPALDAANKALDSLDKADISEIRVFTKPPDMVMTVMEAISILLNAKPDWPTAKQLLGDSNFLRRLLEYDKENIKPQILAKLQKYINNPDFVPEKVEKVSKACKSMCMWVRAMDLYSRVVKEVEPKRQKLRAAQAELDITMATLKEKQALLRQVEEQIQALQDEYDKGVNEKESLAKTMALTKARLVRAGKLTAALGDEQVRWEESIQKFNEEISNIVGNVFIAAACVAYYGAFTAQYRQSLIEYWIQDCQSLEIPINPDFSLINTLGDPYEIRQWNTDGLPRDLISTENGILVTQGRRWPLMIDPQDQANRWIRNKESKNGLKIIKLTDSNFLRTLENSIRLGLPVLLEELRETLDPALEPILLKQTFVSGGRLLIRLGDSDIDYDKNFRFYMTTKLPNPHYLPEVCIKVTIINFTVTKSGLEDQLLSDVVRLEKPELEEQRIKLIVRINTDKNQLKAIEEKILKMLFTSEGNILDNEELIDTLQDSKITSGAIKIRLKEAESTERMINIAREKYRPVATQGSVMYFVIASLSEIDPMYQYSLKYFKQLFNTTIETSVRIDDLQQRMEILLEQTLLTAYVNVSRGLFEQHKLIYSFMLCVEIMRQQGRLTEAEWNFFLRGSAGLEKERPPKPEFPWLVTATWFACCDLEELFPVFKGLTQYIVLFPISIRIGSFETYINPPDQDAYSIMKESDQLITTEKVPTSYNFWHPELSSFHKLILIKCCKEEKVVFALTDFVIENLGKAFIETPPVDLPTLYQDMSYNTPLVFILSTGSDPMGAFQRFARESGYSERVQSISLGQGQGPIAERMIKDAMKSGNWVFLQNCHLAVSWMLAMEELIKTFTDSNVVIKDTFRLFLSSMPSNTFPVTVLQNSVKVTNEPPKGLRANIRRAFTEMMPSFFEENILGRKWRQIIFGICFFHAIIQERKKFGPLGWNICYEFNDSDRECALLNLNLYCQEGKIPWDALIYITGEITYGGRVTDTWDQRCLRTVLKRFFSPETLQDGYKYSESGIYFAPLADSLQEFKDYIENLPLIDDPEIFGMHENANLVYQYKETNTLINTILEVQPRSSSGGEGKSNDEIVQELVASVRTRVPEILEMENASESLFIKDPQGRLNSLTTVLGQEVDRFNNLLRLIHTSLDTLNKAIAGLVVMSEEMEKVYNSFLNNQVPSLWSNTAYPSLKPLGSWVKDLILRTAFVDLWLKRGQPKSFWISGFFFPQGFLTGTLQNHARKYNLPIDELSFKYNMVPVYRDQATVIEAAKTVQFGQELPMDTELPSPEDGVLVHGMFMDASRWDNKDMVIEDALPGQMNPMLPVVHFEPRQNYEPSPTLYHSPLYKTGARAGTLSTTGHSTNFVVTVLLPSKRSKDYWIAKGSALLCQLNE", "length": 4154, "header": "tr|A0A3Q1LW75-1|A0A3Q1LW75_BOVIN Isoform 1 of Dynein axonemal heavy chain 6 OS=Bos taurus OX=9913 GN=DNAH6 PE=1 SV=1 CANONICAL=A0A3Q1LW75-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LW75-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75/entry", "sequence": { "sequence": "MASRLSENELDLKSIGELSENPMLARLNSIRAKGRLSFVTPTENQGDTQVLTFEHTTKAQERTRKRQQPKKLEPLPVLKVHQDHKMPDYIYEQNRNRLIASGVLKPPRSPEEKTSTKSLVQFLEHGEAVKKKKQTQWPSADLSPSPAKLSRTGGTGRRGLYETSSLTYPKYYFHDREEVIKANIRDPLQIVKIIRENEHIGFLYMISAVPRSSIEYDTYNLKVVNYENINKNDYYTISKKAVTHVYNNDIEFIEIDRWEQEYLYHRELTKIPIFSLFRKWKAFNVWKKNVRSKKISGCRKSLQKDLFIVNHYLRPALLKINELCYQLSFMGLCSIEKYHTYTLQEFKAAQIVRVGEVTERLEEFRNEAKDVVRKACRVALRAAGFIPDDCARESSEGHFKMPESGSFIELPTGDAEKMTYTEQASKRHHCMRLTCFIRLNDYLIENTMHVLTVNSASSLLNYLTDKLKRTPSADIIQKWITEEKPEVTDKKGAPVLEKQEEDESLVPMFLTELILTVQSLLFEPSLEDFLDGISGAINHFQNTVLSVPNLVPDSYFDAFTSPYINNKMEEKTCGFGPSLSAVFDDDKNFHTIIFQIKEAIQAAFESAQFYAATFEKFQIFFKENESLDLQDLKLQEPGVKFFSEQLEKYHRQHKDAVALRPTRNVGLLLIDTKQLKEKLIPSPLRCLEVLNYMLPRLSKKKVDAIISEAQDAEYKLEFVPTTTIEYVNSLVFLDEIQERIESLEDEGNVVVQMYKLIEQYQVPTPPEDFAVFATMKPSIVAVRNAIDKSVGDRETSIKQFCLHLGRDLEDLSNEVNEVKMLAQDPQILDINADQEKIKVMLNELLLVLDDLQKRAFQYKSYQKNFKVEVSKFDALEEVSAELKLKQLLWDSLSEWDQLQQEWLKSKFDSLDPELLNSQVSKYAKFVTQLEKGLPPNSVVPQLKSKVEKMKEKLPVIIDLRNPTLKPRHWAAIEQTVDATLVDLEVPLTLEKLAELHVFDFGQEIQDISGQASGEAALETILKKVEDSWKTTEFVVLPHRDSKDVFILGGTDDIQVLLDDSTINIATIASSRYVGPLKARVDEWQKQLALFNQTLEEWLNCQRNWLYLESIFNAPDIQRQLPAEAKMFLQVDKSWKEIMRKVNRLPNALRAATQPGLLETFQNNNALLDQIQKCLEAYLESKRVIFPRFYFLSNDELLEILAQTRNPQAVQPHLRKCFDSISKLEFALLPPTEGKIPGMDAEPEKVYTNDILAMLSPEGERVSLGKGLKARGNVEEWLGKVEEAMFTSLRRLCKAAIADYLGKQRTMWVVAGHPSQVILTVSQIMWCRDLTECLEKEEGNHLEALEDFEKVNFERLNALAAIVRGILPKLHRNIITALITIDVHARDIVTELVQAKVQVVDSFDWQRQLRYYWDVDLDNCVARMALSQYTYGYEYLGACPRLVITPLTDRCYLCLMGALQLDLGGAPAGPAGTGKTETTKDLAKALAIQCVVFNCSDGLDYKMMGRFFSGLAQSGAWCCFDEFNRIDIEVLSVIAQQLITIRNAKAAKLSRFMFEGREIKLVMTCAAFITMNPGYAGRTELPDNLKALFRPFAMMVPNYALIAEVILYSEGFESSKILARKMTQMYKLCSEQLSQQDHYDFGMRAVKSVLVMAGSLKRENPDLSEDVVLIRALRDSNLPKFLTDDAILFSGIISDLFPGVQIPEHDYGILQSTIIDVMKKKNLQPEACMVKKVIQFYETMLVRHGVMLVGPTGGGKTTVYQVLAETLGNLQKLGVDNPFYQPVKTYVLNPKSITMGELYGEVNNITLEWKDGLMALSVRAAVNDTSEDHKWIISDGPVDALWIENMNTVLDDNKMLCLANSERIKLTPQIHMLFEVQDLKVASPATVSRCGMVFVDPEELKWMPYVKTWMQSVSKKLSEETQEYILNLFQRYVDDGLNFINKKCHQAIPQVDISKVTTLCCLLESLILEKDGANLTMEQTKLNTVLCQTFVFCYLWSLGGNLTENHWDSFDTFIRTQFDDNPDARLPSSGDLWSIHMDFDTKRLDPWERIIPTFKYSRDTPFFEMLVPTADTVRFGYLMEKLLAVKHSVLFTGITGVGKSVIAKGLLNRIQESAGYVPVYLNFSAQTSSSRTQEIIESKLERKRKNILGAPGNKRVVIFVDDLNMPRLDRYGSQPPIELLRQYQDFGGFYDRNKLFWKDIQDVTIVSACAPPGGGRNPVTPRFIRHFSMLCLPMPSEHSLKQIFQAILNGFLNDFTPAVKQTASNIVEASVEIYNRMSVDLLPTPAKSHYVFNLRDLSKCVQGILQCDPGTIREEIQIFRLFCHECQRVFHDRLINNEDKHYFHAILTEMANKHFGIAIGLEYFLTRPIIFGDFIKFGADRSDRIYDDMPDMEKIANVLQDYLDDYNLINPKEVKLVFFQDAIEHVSRIARMIRQERGNALLVGVGGTGKQSLTRLAAHICGYRCLQIELSRGYNYDSFHEDLRKLYKLAGVEDRNMVFLFTDTQIVVEEFLEDINNILNSGEVPNLFEKDELEQVLAATRPRAKEVGISEGNRDEVFQYFISRVRQKLHIVLCMSPVGEAFRSRCRMFPSLVNCCTIDWFVQWPREALLSVSKTFFSNVDAVNEELREKLSLMCVNVHLSVSNMAERYYTELRRRYYTTPTSYLELINLYLSMLTEKRKQLVSARERVKNGLTKLLETNVLVDKMKLDLSALEPVLLTKSQDVEALMDKLAVDQENADQVRSVVQEDEAIAKVKAEETQAIADDAQRDLEEALPALDAANKALDSLDKADISEIRVFTKPPDMVMTVMEAISILLNAKPDWPTAKQLLGDSNFLRRLLEYDKENIKPQILAKLQKYINNPDFVPEKVEKVSKACKSMCMWVRAMDLYSRVVKEVEPKRQKLRAAQAELDITMATLKEKQALLRQVEEQIQALQDEYDKGVNEKESLAKTMALTKARLVRAGKLTAALGDEQVRWEESIQKFNEEISNIVGNVFIAAACVAYYGAFTAQYRQSLIEYWIQDCQSLEIPINPDFSLINTLGDPYEIRQWNTDGLPRDLISTENGILVTQGRRWPLMIDPQDQANRWIRNKESKNGLKIIKLTDSNFLRTLENSIRLGLPVLLEELRETLDPALEPILLKQTFVSGGRLLIRLGDSDIDYDKNFRFYMTTKLPNPHYLPEVCIKVTIINFTVTKSGLEDQLLSDVVRLEKPELEEQRIKLIVRINTDKNQLKAIEEKILKMLFTSEGNILDNEELIDTLQDSKITSGAIKIRLKEAESTERMINIAREKYRPVATQGSVMYFVIASLSEIDPMYQYSLKYFKQLFNTTIETSVRIDDLQQRMEILLEQTLLTAYVNVSRGLFEQHKLIYSFMLCVEIMRQQGRLTEAEWNFFLRGSAGLEKERPPKPEFPWLVTATWFACCDLEELFPVFKGLTQYIVLFPISIRIGSFETYINPPDQDAYSIMKESDQLITTEKVPTSYNFWHPELSSFHKLILIKCCKEEKVVFALTDFVIENLGKAFIETPPVDLPTLYQDMSYNTPLVFILSTGSDPMGAFQRFARESGYSERVQSISLGQGQGPIAERMIKDAMKSGNWVFLQNCHLAVSWMLAMEELIKTFTDSNVVIKDTFRLFLSSMPSNTFPVTVLQNSVKVTNEPPKGLRANIRRAFTEMMPSFFEENILGRKWRQIIFGICFFHAIIQERKKFGPLGWNICYEFNDSDRECALLNLNLYCQEGKIPWDALIYITGEITYGGRVTDTWDQRCLRTVLKRFFSPETLQDGYKYSESGIYFAPLADSLQEFKDYIENLPLIDDPEIFGMHENANLVYQYKETNTLINTILEVQPRSSSGGEGKSNDEIVQELVASVRTRVPEILEMENASESLFIKDPQGRLNSLTTVLGQEVDRFNNLLRLIHTSLDTLNKAIAGLVVMSEEMEKVYNSFLNNQVPSLWSNTAYPSLKPLGSWVKDLILRTAFVDLWLKRGQPKSFWISGFFFPQGFLTGTLQNHARKYNLPIDELSFKYNMVPVYRDQATVIEAAKTVQFGQELPMDTELPSPEDGVLVHGMFMDASRWDNKDMVIEDALPGQMNPMLPVVHFEPRQNYEPSPTLYHSPLYKTGARAGTLSTTGHSTNFVVTVLLPSKRSKDYWIAKGSALLCQLNE", "length": 4154, "header": "tr|A0A3Q1LW75-1|A0A3Q1LW75_BOVIN Isoform 1 of Dynein axonemal heavy chain 6 OS=Bos taurus OX=9913 GN=DNAH6 PE=1 SV=1 CANONICAL=A0A3Q1LW75-1" }, "locus": { "chromosome": "11", "start_pos": 50483750, "end_pos": 50204214, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077540.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077540.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064948.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064948.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1751, "start_aa": "Thr", "end_pos": 1751, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1751", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2219, "start_aa": "Thr", "end_pos": 2219, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2219", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2283, "start_aa": "Thr", "end_pos": 2283, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2283", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Structural diversity of axonemes across mammalian motile cilia.", "journal": "Nature", "date": "2025", "authors": "Leung Miguel Ricardo, Sun Chen, Zeng Jianwei, Anderson Jacob R, Niu Qingwei, Huang Wei, Noteborn Willem E M, Brown Alan, Zeev-Ben-Mordehai Tzviya, Zhang Rui", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LW75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75" } ], "reference": [ { "type": "PubMed", "id": "39743588", "url": "https://glygen.org/publication/PubMed/39743588" } ] } ], "pathway": [ { "id": "bta:112448797", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112448797", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E9Q0B6-1", "protein_name": "Dynein, axonemal, heavy chain 6", "gene_name": "Dnah6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFQGTEDEIDLKSIEHQAEENPILARLNKIKAKGILNYVSLKENEPEPPTLVFRHTTKAQERTRKRQQPVKLEPLPVLKVYQDHKQPEYIYEQNRQKLMSSGILKPSPSTADRASIISLEAQEAVKRKQVHRPSADVFSPSPTKLPRTSIGRRGLFGMRSSTYPTYTFHDREEVIKANIRDPLQIIKIVHENEHLGFLYMISAVPKSSIEYDTYNLKVVSYENINKNDYYTISKDAVTHVYNDDIEYIEIERWEQEYLYHRELTKIPIFALFRKWKAFSVWRKNVRSKKITGCRKALRKNLFIVNPYLRPALLKINEMCYLLSFMGLCYIEKFHTYTLQEFKAAQIVRLQEVTERLEVFRCAAKDVVRKSCRFALRAAGFIPDDCEVETYEDYFKANIASLVDGPFDLPTYGESEKMTYTEQASKRHHCMRLTCFIRLNDYLIQNTLHVLTVNTASSLLNFFSDKLKRTPSADVIQKWITEEKPEVTEKKGAPLMEKQEEDESLVPMFLTELILTVQSLLFEPSLEDFLDGISGAINHFENTVLSVPNLVPDSYFDAFTSPFINKKVEEKTCGPGPNLSAVFEDDRNFLTIIMQIKETIHAAFDSARLYAATFEKFQLFFKENESLDLEALKQEEPDVQFFSSQLEKYHKQHKDSVALRPTRNVGLLLIDTKQLKEKLIPSPLRCLEVLNSMLPCLSKKKVDAIISEAQDAEYKLEFMPTTTIEYVNSLVFLDEIQERIETLEEEANVVVQMYKLIEQYQVPTPPEDFAVFATMKPSITAVRNAIDKSVGDRETSIKQFCLHLGRDLEDLNNEVNEVKLLAQDPQILDISADQEKIKTMLSDLQSVLDDLQKRAFQYKSYQKNFKVEVSKFDALEEVSAELRLKQLLWDSLSEWDNLQQEWLKSKFDCLDPEVLNSQVTKYAKFVTQLEKGLPPNSVVPQLKQKVEKMKEKLPVIIDLRNPTLKARHWAAIEQTVDALLVDTEIPLTLERLSELHVFNFAQEIQDISGQASGEAALEIILKKVEDSWKTTEFVILPHRDSKDVFILGGTDDIQVLLDDSTINIATIASSRYVGPLKSRVDDWQKQLSLFNQTLEEWLNCQRNWLYLESIFNAPDIQRQLPAEAKMFLQVDKSWKEIMRKVNRLPNALRAATQPGLLETFQNNNALLDQIQKCLEAYLESKRVIFPRFYFLSNDELLEILAQTRNPQAVQPHLRKCFDSISKLEFALMPPTEGKIPGMDTEPEKVFTNDILAMLSPEGERVGLGKGLKARGNVEEWLGKVEEAMFTSLRRLCKAAIADYQGKPRTEWVIAGHPSQVILTISQIMWCRDLTESLECEGDNVDALEDFEQVNFERLNALAAIVRGNLPKLHRNIITALITIDVHARDIVSELVQAKVDSADSFDWQRQLRYYWDMDLDNCVARMALSQYTYAYEYLGACPRLVITPLTDRCYLCLMGALQLDLGGAPAGPAGTGKTETTKDLAKALAIQCVVFNCSDGLDYKMMGRFFSGLAQSGAWCCFDEFNRIDIEVLSVIAQQLITIRNAKAAKLSRFMFEGREIKLVMTCAAFITMNPGYAGRTELPDNLKALFRPMAMMVPNYALIAEVILYSEGFESSKILARKMTQMYKLCSEQLSQQDHYDFGMRAVKSVLVMAGSLKRENPDLSEDVVLIRALRDSNLPKFLTDDALLFSGIISDLFPGVQIPEHDYGILQSTIVEVMINQNLQPELCMVKKVIQLYETMLVRHGVMLVGPTGGGKTTVYQVLAETLGNLEKLNTDNPFYQPVKTYVLNPKSITMGELYGEVNNVTLEWKDGLMALSVRAAVNDTSEDHKWIISDGPVDALWIENMNTVLDDNKMLCLANSERIKLTPQIHMLFEVQDLRVASPATVSRCGMVFVDPEELKWMPYVKTWMRTMSKKLNDEVQEYLLNLFNRYVDDGLHFVNKKCTQAIPQVDISKVTTLCCLLESLLLSKDGNILSMEQMKLNTVLCQTFVFCYLWSLGGNLTENYWDSFDTFIRTQFDDNPDARLPSSGDLWSIHIDFDTKRLDPWERIIPTFKYSRDVPFFEMLVPTTDTVRYGYLMEKLLAVRHSVLFTGTTGVGKSVIAKGLLNRIQESAGYVPVYLNFSAQTSSSRTQEIIESKLERKRKNILGAPGNKQVVIFVDDLNMPRLDRYGSQPPIELLRQYQDFGGFYDRNKLFWKEIQDVTIVSACAPPGGGRNPVTPRFIRHFSMLCLPMPSEHSLKQIFQAILNGFLADFPEAVKQTSSNIVEAAVEIYNRMSVDLLPTPAKSHYVFNLRDLSKCVQGILQCDPGTIREELQIFRLFCHECQRVFHDRLINNEDKHYFHLILTEMANKHFGIAIDLEYFLSKPIIFGDFIKFGAEKSDRIYDDLPDMEKIENVLQDYLDDYNLTNPKEVKLVFFQDAIEHVSRIARMIRQERGNALLVGVGGTGKQSLTRLAAHICGYKCMQIELSRGYNYDNFHEDLRKLYKMAGVEDKDMVFLFTDTQIVVEEFLEDINNILNSGEVPNLFEKDELEHVLAATRPKAKEVGISEGNRDEVFQYFISRVRQKLHIVLCMSPVGEAFRSRCRMFPSLVNCCTIDWFVQWPREALLSVSKSFFSSVDTGNDDLREKLSLMCVNVHLSVSHMAERYYNELRRRYYTTPTSYLELINLYLTMLTEKRKQLVSARDRVKNGLTKLLETNVLVDKMKLDLSALEPVLLQKSQDVEALMEKLVVDQESADQVRNVVQEDEAIAKVKAEETQAIADDAQRDLEEALPALEAANKALDSLDKADISEIRVFTKPPDLVMTVMEAISILLNAKPDWPTAKQLLGDSNFLRRLLEYDKENIKPQILLKLQKYINNPDFVPEKVEKVSKACKSMCMWVRAMDLYSRVVKEVEPKRQKLRAAQAELDATMATLKEKQALLKQVEDQIKTLQDKYEKGVNEKESLAKNMALTKARLIRAGKLTAALGDEQVRWEESIEKFQEELANIVGNVFIAAACVAYYGAFTAQYRQLLIEWWIESCLALEIPIDPSFSLINILGDPYEIRQWNTDGLPRDLISTENGILVTQGRRWPLMIDPQDQANRWIRNKESKSGLKVIKLTDTNFLRILENSIRLGLPVLLEELREVLDPALEPILLKQTFMSGGRLLIHLGDSDIDYDKSFRFYMTSKMPNPHYLPEVCIKVTIINFTVTKSGLEDQLLSDVVRLEKPELEEQRIQLIVRINSDKNQLKSIEDKILKLLFTSEGNILDNEELIDTLQDSKITSGAIKTRLKEAESTELMINIARERYRPVATQGSVMYFVIASLSEIDPMYQYSLKYFKQLFNTTIETSEKSDNLHERLKILLQQTLLTAYTNVSRGLFEQHKLIYSFMLCVDIMREHEQLTEAEWNFFLRGSAGMEKERPPKPEAPWLPIQMWFSCCDLEESFPIFEGLTKHILLRPISIKLGSFETYINPPVWEGYPKQRHEEEKDHVWGLDFSSFHKLILVKCCKEEKVVFALTDFVIENLGKQFIETPPVDLATLYQDMSNSTPLVFILSTGSDPMGAFQRFARESGYAERVQSISLGQGQGPIAEKMIKDAMKTGNWVFLQNCHLAVSWMLAMEELIKTFTDPNQTIKDTFRLFLSSMPCSTFPVTVLQNSVKVTNEPPKGLRANIRRAFTEMTPSFFEENILGMKWRKLIFGICFFHAIIQERKKFGPLGWNICYEFNDSDRECALLNLNLYCHEGKIPWDALIYITGEITYGGRVTDTWDQRCLRTVLKRFFSPETLDDDYTYSDSGIYFAPLADSLQDFKEYIEDLPLIDDPEIFGMHENANLVFQYKETNTLITTILEVQPRSSSGGQGKSNDEIVQELVASIQTRVPESLQMEGASESLFVKDPQGRLNSLTTVLGQEVDRFNNLLKLIHISLETLNKAIAGLVVMSEEMEKVYQSFLNNQVPSLWSNTAYPSLKPLGSWVKDLILRTEFVDLWLKRGQPKSFWISGFFFPQGFLTGTLQNHARKYNLPIDELSFKYNMIPVYRDQAAVIESAKDIQFGTELPMDKELPSPEDGVLVHGMFMDASRWDDKDMVIEDALPGQMNPMLPVVHFEPKQNYEPVHTLYHSPLYKTGARAGTLSTTGHSTNFVVTVLLPSKRISDYWISKGSALLCQLSE", "length": 4144 }, "evidence": [ { "id": "A0A3Q1LW75", "url": "https://omabrowser.org/oma/group/A0A3Q1LW75/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1LXT8-1", "protein_name": "Dynein, axonemal, heavy chain 6", "gene_name": "Dnah6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESLRKDGFRIRMAFQGTENEIDLKSMENQEEENPVLTRLNKIRAKGVLNYASLKENEPEPQTLVFRHTTKAQEKTRKRQQPVKLEPLPVLKLYQDHKQPEYIYEQNRQQLMSTGILKPSPSMIERSSIGSLEAQEALKRKQVLRPSADVFSLSPSKLPRTSIGRRGLFGMRSSTYPKYTFNDREEVVKANIRDPLQIIKIVHENEHLGFLYMIPAVPKSSIEYDTYNLKVVSYENINKNDYYTISKDAVTHVFNDDIEYIETERWEQEYLYHRELTKIPIFSLFRKWKAFSVWRKNVRSKKITGCRKALRKNLFIVNPYLRPALLKINDMCYQLSFMGLCYIEKFHTYTLQEFKAAQVVRVQEVTERLEYFRFEAKDVVRKSCRFALRAAGFIPDDCEVETHEDYFKINIASFIDAPSDLPTYGESEKMTYTEQASKRHHCMRLTCFIRLNDYLIQNTLHVLTVNTASSLLNYLSDKLKRTPSADVIQKWITEDKPEVIEKKGAPMMEKQEEDESLIPMFLTELILTVQSLLFEPSLEDFLDGISGIINHFENTVLSVPNLVPDSYFNAFTSPFINKKVEEKTCGPGPSLSAVFEDDRNFLTIIQQIKETIHSAFDSARLYAATFEKFQIFFKENESLDLEALKEEEPDVEFFSSQLEKYHKQHKDSVALKPTRNVGLLLIDTKQLKEKLIPSPLRCLEVLNLMLPRLSKKKVDAIISEAQDAEYKLEFVPTTTIEYVNSLVFLDEIQERIETLEEEGNTVVQMYKLIEQYQVLTPPEDFAVFATMKPSITAVRNAIDKSVGDRESSIKQFCLHLGRDLEDLNNEVNEVKLLAQDPQILDISADPEKIKTMLSDLQSVLDDLQKRAFQYKSYQKNFKVEVSKFDALEEVCAELRLKQLLWDSLSEWDKLQQEWLKSKFDCLDPEVLNGQVTKYAKFVTQLEKGLPPNSVVPQLKQKVERMKEKLPVINDLRNPTLKPRHWSAIEQTVDALLVDIEIPLTLERLSELHVFDFAQEIQDISGQASGEAALEIILKKVEDSWKTTEFVILPHRDSKDVFILGGTDDIQVLLDDSTINVATIASSRYVGPLKTRVDDWQKQLSLFNQTLEEWLNCQRNWLYLESIFNAPDIQRQLPAEAKMFLQVDKSWKEIMRKVNRLPNALRAATQPGLLETFQNNNALLDQIQKCLEAYLESKRVIFPRFYFLSNDELLEILAQTRNPQAVQPHLRKCFDSISKLEFALMPPTEGKIPGIDTEPEKVFTNDILAMLSPEGERVGLGKGLKARGNVEEWLGKVEEAMFSSLRRLCKAAIADYQGKLRTEWVIAGHPSQVILTISQIMWCRDLTESLECEDNHLEALEKFEQVNFERLNALAAIVRGSLPKLHRNIITALITIDVHARDIVSELVQSKVDSAESFDWQRQLRYYWDVDLDNCVARMALSQYTYAYEYLGACPRLVITPLTDRCYLCLMGALQLDLGGAPAGPAGTGKTETTKDLAKALAIQCVVFNCSDGLDYKMMGRFFSGLAQSGAWCCFDEFNRIDIEVLSVIAQQLITIRNAKAAKLSRFMFEGREIKLVMTCAAFITMNPGYAGRTELPDNLKALFRPMAMMVPNYALIAEVILYSEGFESSKILARKMTQMYKLCSEQLSQQDHYDFGMRAVKSVLVMAGSLKRENPDLSEDVVLIRALRDSNLPKFLTDDALLFSGIISDLFPGVQIPEHDYGILHSTIVDVMISQNLQPEICMVKKVIQLYETMLVRHGVMLVGPTGGGKTTVYQVLAETLGNLEKLNTGNPFYQPVKTFVLNPKSITMGELYGEVNNVTLEWKDGLMALSVRAAVNDTSEDHKWIISDGPVDALWIENMNTVLDDNKMLCLANSERIKLTPQVHMLFEVQDLKVASPATVSRCGMVFVDPEELKWMPYVKTWMSTLSKKLSEEIREYLLNLFNRYVDDGLRFVNKKCTQAIPQVDISKVTTLCCLLESLLLSKDGNILSLEQMKLNTVVCQTFVFCYLWSLGGNLTENHWDSFDTFIRTQFDDNPDARLPSSGDLWSIHVDFDTKRLDPWERIIPTFKYSREVPFFEMLVPTADTVRYGYLMEKLLAVRHSVLFTGTTGVGKSVIAKGLLNRIQESAGYVPVYLNFSAQTSSARTQEIIESKLERKRKNILGAPGNKQVVIFVDDLNMPRLDRYGSQPPIELLRQYQDFGGFYDRNKLFWKEIQDVTIVSACAPPGGGRNPVTPRFIRHFSMLCLPMPSEHSLKQIFQAILNGFLADFTEAVKQTSSNIVEAAVEIYNRMSVDLLPTPAKSHYVFNLRDLSKCVQGILQCDPGTIREEMQIFRLFCHECQRVFHDRLINNEDKHYFHVILTEMANKHFGIAIDLEYFLSKPIIFGDFIKFGADKADRIYDDLPDIEKIENVLQDYLDDYNLTNPKEVKLVFFQDAIEHVSRIARMIRQERGNALLVGVGGTGKQSLTRLAAHICGYKCLQIELSRGYNYDSFHEDLRKLYKMAGVEDKNMVFLFTDTQIVVEEFLEDINNILNSGEVPNLFEKDELEQVLAATRPKAKEVGISEGNRDEVFQYFISRVRQKLHIVLCMSPVGEAFRSRCRMFPSLVNCCTIDWFVQWPREALLSVSKSFFSVVDTGNEELKEKLSLMCVNVHLSVSHMADRYYSELRRRYYTTPTSYLELINLYLTMLTEKRKQLVSARDRVTNGLTKLLETNILVDKMKLDLSALEPVLFQKSQDVEALMEKLVVDQESADQVRNVVQEDEAIAKVKAEETQAIADDAQRDLEEALPALEAANKALDSLDKADISEIRVFTKPPDLVMTVMEAISILLNAKPDWPTAKQLLGDSNFLRRLLEYDKENIKPQILSKLQRYINNPDFVPEKVEKVSKACKSMCMWVRAMDLYSRVVKEVEPKRQKLRAAQAELDATITTLKEKQALLKQVEEQIRALQEEYDKGVNEKESLAKTMALTKARLVRAGKLTAALGDEQVRWEESIEKFQEEIANIVGNVFIAAACVAYYGAFTAQYRQLLIECWIDSCLALDIPIDPSFSLINTLGDPYEIRQWNADGLPRDLISTENGILVTQGRRWPLMIDPQDQANRWIRNKESKSGLKVIKLTDTNFLRILENSIRLGLPVLLEELREVLDPALEPILLKQTFMSGGRLLIRLGDSDIDYDKSFRFYMTTKMPNPHYLPEVCIKVTIINFTVTKSGLEDQLLSDVVRLEKPELEGQRVQLIVRINSDKNQLKSIEDKILKLLFTSEGNILDNEELIDTLQDSKITSGAIKTRLKEAESTELMINIARERYRPVATQGSVMYFVIASLSEIDPMYQYSLKYFKQLFNTTIETSEKSDSLQERLAILLQQTLLTAYTNVSRGLFEQHKLIYSFMLCVDIMRQQEQLTEAEWNFFLRGSAGMEKERPPKPEAPWLPIQMWFSCCDLEEWFPIFEGLTRHILLHPISISLGSFETYINPQSWEGYPKQRHEEEKEHVWGSNFSSFHKLILVKCCKEEKVVFALTDFVIENLGKQFIETPPVDLATLYQDMSSSTPLVFILSTGSDPMGAFQRFARESGYAERVQSISLGQGQGPIAEKMIKDATKSGNWVFLQNCHLAVSWMLAMEELIKTFTDPNQSIKDTFRLFLSSMPCSTFPVTVLQNSVKVTNEPPKGLRANIRRAFTEMTPSFFEENILGMKWRKLIFGICFFHAIIQERKKFGPLGWNICYEFNDSDRECALLNLNLYCHEGKIPWDALIYITGEITYGGRVTDTWDQRCLRTVLKRFFSPETLEDEYTYSESGIYFAPLADSLQEFKDYIEDLPLIDDPEIFGMHENANLVFQYKETNTLITTILEVQPRSSSGGEGKSNDEIVQELVASIRTRVPESLQMEGASETLFVKDPQGRLNSLTTVLGQEVDRFNNLLKLIHISLETLNKAIAGLVVMSEEMEKVYQSFLNNQVPSLWSNTAYPSLKPLGSWVKDLILRTAFVDLWLKRGQPKSFWISGFFFPQGFLTGTLQNHARKYNLPIDELSFKYNMIPVYRDQALVIEAAKDIQFGTELPMDKELPTPEDGVLVHGMFMDASRWDDKDMIIEDALPGQMNPMLPVVHFEPQQNYEPIQTLYHSPLYKTGARAGTLSTTGHSTNFVVTVLLPSKRPSDYWIAKGSALLCQLSE", "length": 4156 }, "evidence": [ { "id": "A0A3Q1LW75", "url": "https://omabrowser.org/oma/group/A0A3Q1LW75/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9C0G6-1", "protein_name": "Dynein axonemal heavy chain 6", "gene_name": "DNAH6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTFRATDSEFDLTNIEEYAENSALSRLNNIKAKQRVSYVTSTENESDTQILTFRHITKAQEKTRKRQQPIKLEPLPVLKVYQDHKQPEYIHEQNRFQLMTAGIIKRPVSIAKKSFATSSTQFLEHQDAVKKMQIHRPYVEVFSPSPPKLPHTGIGKRGLFGTRSSAYPKYTFHDREEVVKANIRDPLQIIKIIRENEHLGFLYMIPAVPRSSIEYDTYNLKVVSYENINKNDYYTISQRAVTHIYNEDIEFIEIDRWEQEYLYHRELTKIPIFSLFRKWKAFSVWRKNVRSKKITGCQKSLQKNLFIVNPHLRPALLKINELCYHLSFMGLCYIEKCHTYTLQEFKAAQVIRLAEVTERLGEFRNEAKYVVRRACRFALRAAGFVPDDCAFGPFEDYHKVQSSGSFINTPHELPTYGDSEKMTYTEQASKRHYCMRLTCFIRLNDYLIENTMHILTVNAVNSLLNHLTDKLKRTPSADVIQKWITEEKPEVPDKKGTLMVEKQEEDESLIPMFLTELMLTVQSLLFEPSLEDFLDGILGAVNHCQNTVLSVPNLVPDSYFDAFTSPYINNKLEGKTCGTGPSLAAVFEDDKNFHTIISQIKETIQAAFESARIYAATFEKFQIFFKENESLDLQALKLQEPDINFFSEQLEKYHKQHKDAVALRPTRNVGLLLIDTRLLREKLIPSPLRCLEVLNFMLPRQSKKKVDAIIFEAQDAEYKLEFVPTTTTEYVHSLLFLDEIQERIESLEDEGNIVTQMYKLMEQYQVPTPPEDFAVFATMKPSIVAVRNAIDKSVGDRESSIKQFCVHLGSDLEELNNEVNEVKLQAQDPQILDISADQDKIRLILNNLQSVLADLQKRAFQYKSYQKNFKVEVSKFEALEEVSAELKLKQLLWDSFSEWDKLQQEWLKSKFDCLDPEVLNGQVSKYAKFVTQLEKGLPPNSVVPQLKYKVEKMKEKLPVIIDLRNPTLKARHWAAIEQTVDATLVDAEIPLTLERLSQLHVFDFGQEIQDISGQASGEAALEAILKKVEDSWKTTEFVILPHRDSKDVFILGGTDDIQVLLDDSTINVATLASSRYLGPLKTRVDEWQKQLALFNQTLEEWLTCQRNWLYLESIFNAPDIQRQLPAEAKMFLQVDKSWKEIMRKVNRLPNALRAATQPGLLETFQNNNALLDQIQKCLEAYLESKRVIFPRFYFLSNDELLEILAQTRNPQAVQPHLRKCFDSISKLEFALMPPAEGKIPGIDGEPEKVYTNDILAMLSPEGERVSLGKGLKARGNVEEWLGKVEEAMFTSLRRLCKAAIADYQGKLRTDWVVAGHPSQVILTVSQIMWCRDLTECLETEHSNHIQALKNFEKVNFERLNALAAIVQGSLPKLHRNILTALITIDVHARDIVTELVQSKVETVESFDWQRQLRYYWDIDLDNCVARMALSQYTYGYEYLGACPRLVITPLTDRCYLCLMGALQLDLGGAPAGPAGTGKTETTKDLAKALAIQCVVFNCSDGLDYKMMGRFFSGLAQSGAWCCFDEFNRIDIEVLSVIAQQLITIRNAKAAKLSRFMFEGREIKLVMTCAAFITMNPGYAGRTELPDNLKALFRPFAMMVPNYALIAEVILYSEGFESSKILARKMTQMYKLCSEQLSQQDHYDFGMRAVKSVLVMAGSLKRENPDLNEDVVLIRALQDSNLPKFLTDDALLFSGIISDLFPGVQIPEHDYGILQSTIVDVMNRQNLQPEMCMVRKVIQFYETMLVRHGVMLVGPTGGGKTTVYRILAETLGNLQKLGIENSFYQAVKTYVLNPKSITMGELYGEVNNLTLEWKDGLMALSVRAAVNDTSEDHKWIISDGPVDALWIENMNTVLDDNKMLCLANSERIKLTPQIHMLFEVQDLRVASPATVSRCGMVFVDPEELKWMPYVKTWMKGISKKLTEETQEYILNLFQRYVDEGLHFINKKCSQAIPQVDISKVTTLCCLLESLILGKDGVNLAMEQTKLNTILCQTFVFCYLWSLGGNLTENYYDSFDTFIRTQFDDNPDARLPNSGDLWSIHMDFDTKRLDPWERIIPTFKYNRDVPFFEMLVPTTDTVRYGYLMEKLLAVKHSVLFTGITGVGKSVIAKGLLNKIQESAGYVPVYLNFSAQTSSARTQEIIESKLERKRKNILGAPGNKRIVIFVDDLNMPRLDRYGSQPPIELLRQYQDFGGFYDRNKLFWKEIQDVTIISACAPPGGGRNPVTPRFIRHFSMLCLPMPSEHSLKQIFQAILNGFLSDFPPAVKQTASSIVEASVEIYNKMSVDLLPTPAKSHYVFNLRDLSKCVQGILQCDPGTIREEIQIFRLFCHECQRVFHDRLINNEDKHYFHVILTEMANKHFGIAIDLEYFLNKPIIFGDFIKFGADKADRIYDDMPDIEKTANVLQDYLDDYNLTNPKEVKLVFFQDAIEHVSRIARMIRQERGNALLVGVGGTGKQSLTRLAAHICGYKCLQIELSRGYNYDSFHEDLRKLYKMAGVEDKNMVFLFTDTQIVVEEFLEDINNILNSGEVPNLFEKDELEQVLAATRPRAKEVGISEGNRDEVFQYFISKVRQKLHIVLCMSPVGEAFRSRCRMFPSLVNCCTIDWFVQWPREALLSVSKTFFSQVDAGNEELKEKLPLMCVNVHLSVSSMAERYYNELRRRYYTTPTSYLELINLYLSMLSEKRKQIISARDRVKNGLTKLLETNILVDKMKLDLSALEPVLLAKSEDVEALMEKLAVDQESADQVRNTVQEDEATAKVKAEETQAIADDAQRDLDEALPALDAANKALDSLDKADISEIRVFTKPPDLVMTVMEAISILLNAKPDWPSAKQLLGDSNFLKRLLEYDKENIKPQILAKLQKYINNPDFVPEKVEKVSKACKSMCMWVRAMDLYSRVVKVVEPKRQKLRAAQAELDITMATLREKQALLRQVEDQIQALQDEYDKGVNEKESLAKTMALTKARLVRAGKLTAALEDEQVRWEESIQKFEEEISNITGNVFIAAACVAYYGAFTAQYRQSLIECWIQDCQSLEIPIDPSFSLINILGDPYEIRQWNTDGLPRDLISTENGILVTQGRRWPLMIDPQDQANRWIRNKESKSGLKIIKLTDSNFLRILENSIRLGLPVLLEELKETLDPALEPILLKQIFISGGRLLIRLGDSDIDYDKNFRFYMTTKMPNPHYLPEVCIKVTIINFTVTKSGLEDQLLSDVVRLEKPRLEEQRIKLIVRINTDKNQLKTIEEKILRMLFTSEGNILDNEELIDTLQDSKITSGAIKTRLEEAESTEQMINVAREKYRPVATQGSVMYFVIASLSEIDPMYQYSLKYFKQLFNTTIETSVKTENLQQRLDVLLEQTLLTAYVNVSRGLFEQHKLIYSFMLCVEMMRQQGTLSDAEWNFFLRGSAGLEKERPPKPEAPWLPTATWFACCDLEESFPVFHGLTQNILSHPISIRLGSFETYINPQKWEGYSKMKHEDKHMRQEKEAAHQDPWSAGLSSFHKLILIKCCKEEKVVFALTDFVIENLGKQFIETPPVDLPTLYQDMSCNTPLVFILSTGSDPMGAFQRFARESGYSERVQSISLGQGQGPIAEKMVKDAMKSGNWVFLQNCHLAVSWMLAMEELIKTFTDPDSAIKDTFRLFLSSMPSNTFPVTVLQNSVKVTNEPPKGLRANIRRAFTEMTPSFFEENILGKKWRQIIFGICFFHAIIQERKKFGPLGWNICYEFNDSDRECALLNLKLYCKEGKIPWDALIYITGEITYGGRVTDSWDQRCLRTILKRFFSPETLEEDYKYSESGIYFAPMADSLQEFKDYIENLPLIDDPEIFGMHENANLVFQYKETSTLINTILEVQPRSSTGGEGKSNDEIVQELVASVQTRVPEKLEMEGASESLFVKDLQGRLNSLTTVLGQEVDRFNNLLKLIHTSLETLNKAIAGFVVMSEEMEKVYNSFLNNQVPALWSNTAYPSLKPLGSWVKDLILRTSFVDLWLKRGQPKSYWISGFFFPQGFLTGTLQNHARKYNLPIDELSFKYSVIPTYRDQAAVIEAAKTVQFGQELPMDMELPSPEDGVLVHGMFMDASRWDDKEMVIEDALPGQMNPVLPVVHFEPQQNYKPSPTLYHCPLYKTGARAGTLSTTGHSTNFVVTVLLPSKRSKDYWIAKGSALLCQLSE", "length": 4158 }, "evidence": [ { "id": "A0A3Q1LW75", "url": "https://omabrowser.org/oma/group/A0A3Q1LW75/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VWZ3-1", "protein_name": "Dynein heavy chain at 16F", "gene_name": "Dhc16F", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSGMNRHLISKGKDRSKIKIKGKEKEKERKKDEDDDGSRKARERGRSRRQSAGGGDHSVDMGFKRVTGEDRPSSMSMDRLDSDFAAFTDRASDANDGSITGPADGNGKKAQTGGKQKRASKHRLNFSTSKSAGSGTGNKSRSASTTKITTGASLIPDLNLIINRMRNMPDDSFVYMDYMLPHDSEYFTPYSLREVEYKDLNTYEPFYTVTRHGVTFWHCSENFFTPLDQWQQEFKQFLSIIQIRSFSIFRLWKGFKVWEKTIKWRKLNEARDYLQNNLFIVIPQLAKAILRMRSDIVQLQRLNFVNVSNIENWHPFYFLETHMRIYEQLHKTFTDFREFIAKTIFRACTDAIQARGFYPDDEVNYYPSLKKMREAHSFMDRARKRAFCKTLTNFLTYCDMMVYQMLYRITKKSFEDLATSFEVHDEVGPSEADINKHDRVDKRIEKQRPQDKPQSPFFLAMLRLLPDRIDIEPSEDIIRIIFQRITGLILETVLEIHPFTTDPFFTQYTQPSIMGRQEEVLYEGAPDLHYLLRADIRFQYNRKNMFVLIRKAYERARLYTQRFHQIRENFEIDNSTDPTVLNTERDLQILRAYCDRYCNNVRALDGILEYVFLGLLKLTQTNFKDTVTPVCSRLQNVLATYLPKLAEEETTRLYEEAQDFHGRICYEPHETLEIVAHIRFLDKCSTELDGIFDGIDYVHDLLLIIKDFGIPIDDDSKEDYMDTEDYLNRTRETLEEIREKRQDFINRLEDAMQDDIAALKEDIHEVAIEALQPWLLDANSNRLSVTNKLDSMLERLNKCRETADEFLGYQKEFQIDLTMYDEMASGFYDIRMRQNLYRTWSDWEESLAEWIVSDFNTLNVVDMVELNSKTIKNCMQFQKYLPENNIVPVLQKSAEAFKEKLPVIGYLRNPNLRARHWAEIEDLLNRKFFQEKDILIQTYEDVHAFDDVAIGEALMQISSQATGEVQLENMLKGIETTWKETELSIVPHHDAKDVFILAGTEELQAVLDDSNVNINTIAASKFVGPIKSKVDEWINAMDQFAKTFESWMDCQGAWIYLEAIFASADIQRQLPHEAKMFFTVDKSFKETVRQAKKVALALPTMSSVDVHKVLVENNRLLDLISRGLEAYLEVKRVVFPRFYFLSNDELLEILAQTRIPQAVQPHLRKCFDAIYRLEFGSKEGGDGKMVATNDIVAFLSPEGEKLQFGKGLKARGAVEEWLSKVEEAMFVSCKRYMRFGYQCYPAKEREDWFQDHPNQVVLTVSQVQWAADIHRIYEGKERNPLNILEKMAKFEIKCLKDLGALAALTRKNISSLLRKILCALITIDVHAKDSVRMLIEKEVCKASDFNWLKMLRFYWADETETVYSRMAAANIPYYYEYLGAGGVLVLTPLTDRCYLCLMGAFQMDLGGAPAGPAGTGKTETTKDLAKALAKQCVVFNCSDGLDYKMMGRFFSGLAQCGAWCCFDEFNRIDIEVLSVIAQQLITIRTAKAMRVKRFIFEGREIKINRSCCVFITMNPGYAGRTELPDNLKALFRPISMMVPDYALISEVILYSEGFEDPKILARKMVQMYQLCSQQLSQQNHYDFGMRAVKSVLVMAGALKRASPNQREDITLIAALRDSNIPKFLADDAVLFRGILSDLFPGVELPDSQHPHLEASLRLGLRQKNLQAVPTTIRKCLQLYETMCVRWGVMLVGPTGGGKSVVLHALEFALSHLFENEVQDPNFRPVVIQTMNPKAVTMNELYGYVDLKTLEWQDGLLGLAVRTATTVEDEIHQWIMCDGPVDAVWIENLNTVLDDNKMLCLANSERIKLTAWIHMLFEVQDLLQASPATVSRCGMVYVDPGDLGWIPLIDTWREVDMKHKLPAPLAEFCYQLFVGYFDKALKIERKRAVYTIHQVLGSKVRLCCELNSAQFEAVKWSAMSEEQGKELVTKIFAWAVLWAIASNLKDAEKVSFEEQWSKAIAQHPNMTLPNFTLWNYRIDLEKMDWGSWIDIMAKFVFDPETSYYDMQVPTVDTTKYGYVSDLLFKRGMPVMVTGDTGVGKTVLAISCMKRLSQGNVIPVILNFSAQTSSNRTQEMIEGPLEKRKKTQLGAPVGKTVIVFIDDVNMPKLDTYGASPAIELLRQFLDFKGFYDREKLYWKEILDVVLGCACAPPGGGRNPLTPRFVRHFALFSLPKPNEETLTQIFNGILRGFLQTFSSAVRALSEPMVNACVDVYMRVATVMLPTPDKSHYIFNLRDLSKCIQGILQASNLHYNQENQILRLFYHETTRVFHDRLINIEDKNIFKALMKEVCMDHFNRPVINDNEPPILFGDFMVFGKPKNERIYDEIRDHTKLESVLNDYIADYNSVAVGKQMKLILFQDAMEHTVRLARLLRSDRGNGLLVGVAGMGKQSLTRLASHVNEYNCWQIEMRRNYDLNAFHEDLRVLYRIAGIDNQPVTFLLIDSQIVEEEFLEDINNILNSGEVPNLFEGDEFEKIILDARDGCNENRKDDPCTRDDIYKFFINRVRNNLHVVMSMSPVGDAFRRRCRMFPSLVNCTTIDWFTSWPTEALYSVALGLLTKIAPKMEDRISLASTTVFMHKTVEDASVKFYKEMKRHYYTTPSSYLELLKLYQNLLKIKNMEIIAKRKRIANGLNKLLETNEVIAVMGKELEVMVPQLDEKSAMMKSLVDNLTKETKQADAVKQSVLEDEMNAKEKAAVAQAISEDAGKDLEIAMPALREAEEALKGLTKADINELKSFTTPPALVQFCMEAVCILLGVKPTWASAKAIMADINFIKRLFEYDKEHMKEDTLKKVKKYIDHKDFVPAKFEKVSKVAKSMSMWVISMDKFSKVYKVVEPKIKRKEAAEAELKEVMTVLRQKQKELAAVEAKIQGLRDSLEEKQREFQVIQDNVDLTYGRINRAGRLTSALSDEQVRWRETVKSLTGDLACVPGDVLVAAACVAYLGAFSHEYRRDMSALWVSKCREHKIPSSPEFNLLKVLGDPYEMRQWNVDGLPKDNISIENGIYATRALRWALMIDPQEQANRWIRNMERANNLQVIKMTDSTMMRVLENAVRQGYPVLLEEINETIDPSLRPILQRETYRFEGRTYLKLGDMVIDYDDNFKLYMTTKLPNPHYLPEVCINVTLVNFLVTESGLEDQLLADIVAIELPAMEIQRNDLVVKINSDKQQLLALEDKVLKLLFNSEGNILDDEELVETLNDAKETSLIIAARLIDTEETEKVITASRERYRILASRGAILYFVVAGLAEIDPMYQYSLKYFTQVFCNVLRLDHPPQSVEVRISTLMTDELRAIFDNISRGLFENHKIIFSFLLALSVERQEGRVTEEEFLFLSRGPVGNIRTKIQPAKIKMSQIEWDSCIFLEDNFSSFFSGLTDELDKPFFIQMQENKEVFDFAQTNQPPTDKWNKRLRVFHKLMFISAFRKPRFLLNVVCYLQSTVGKYFTEASGGTQLSSVYLDTSAVTPLIFVLSTGSDPMSGFLKFTTQMQFTDKYYSISLGQGQGPLAENLIEKSLRLGHWVFLQNCHLATSFMQTLETIVRNLTLGITKAHVDFRLYLSSMPIQTFPISVLQNSVKITNEPPKGIKANVFGALTDLKQDFFEQHIQNGNWRAIVFGLCMFHAVLLERRKFGPLGWNITYEFSESDRECGLKTLDFFIDREVLDEIPWEAILYINGDITWGGRVTDYWDLRCLRTILTIFSSKRIIQPDYKYCRGDSYYRDPRKKTLTEYSAYVQGFPVLEDPEIFGMNQNANIVFQTKETAFFINTLLLGQPRSAADEGQAMENEIAQQTIARIQKALATKIKREPIHDTLSVLDAKGQVPSLTIVLVQEIDRFNIALGIIHDSLVNLSKAIKGLVVMSEELENVFKALLSNQVPASWAKRSFLSIKPLPSYISDFQRRIDFIQQWAENGAPRSYWISGFFFPQSFLTGVLQTYARRRVLPIDSLKIDFDVFERELVQQDFFEMHTNNMSDQKLYGNLPECTDAIINVHGIFIEAARWDLSKGGLCDANFGELFSRMPVVRFKPCLEISPTVRYEAPLYKTQQRSGVLSTTGHSTNFILAVLLRSHNDPEFWIMRGTALVSAVLENIC", "length": 4081 }, "evidence": [ { "id": "A0A3Q1LW75", "url": "https://omabrowser.org/oma/group/A0A3Q1LW75/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cilium movement involved in cell motility", "id": "GO:0060294", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060294", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LW75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LW75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75" } ], "pmid": "" }, { "name": "minus-end-directed microtubule motor activity", "id": "GO:0008569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008569", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LW75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75" } ], "pmid": "" }, { "name": "dynein light intermediate chain binding", "id": "GO:0051959", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051959", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LW75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75" } ], "pmid": "" }, { "name": "dynein intermediate chain binding", "id": "GO:0045505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045505", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LW75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LW75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LW75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LW75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75" } ], "pmid": "" }, { "name": "dynein complex", "id": "GO:0030286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030286", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LW75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75" } ], "pmid": "" }, { "name": "9+2 motile cilium", "id": "GO:0097729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097729", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LW75", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1091, "end_pos": 1093, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1493, "end_pos": 1495, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1803, "end_pos": 1805, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1822, "end_pos": 1824, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1973, "end_pos": 1975, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2000, "end_pos": 2002, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2121, "end_pos": 2123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3186, "end_pos": 3188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3323, "end_pos": 3325, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3353, "end_pos": 3355, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3713, "end_pos": 3715, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3873, "end_pos": 3875, "annotation": "n_glycosylation_sequon" }, { "start_pos": 624, "end_pos": 626, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LW75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW75" }, { "id": "SM00382", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AAA+ ATPase", "eco_id": "ECO_0000259", "start_pos": 1460, "end_pos": 1563, "start_aa": "Leu", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1751, 2219, 2283 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1091, "end_pos": 1093 }, { "start_pos": 1493, "end_pos": 1495 }, { "start_pos": 1803, "end_pos": 1805 }, { "start_pos": 1822, "end_pos": 1824 }, { "start_pos": 1973, "end_pos": 1975 }, { "start_pos": 2000, "end_pos": 2002 }, { "start_pos": 2121, "end_pos": 2123 }, { "start_pos": 3186, "end_pos": 3188 }, { "start_pos": 3323, "end_pos": 3325 }, { "start_pos": 3353, "end_pos": 3355 }, { "start_pos": 3713, "end_pos": 3715 }, { "start_pos": 3873, "end_pos": 3875 }, { "start_pos": 624, "end_pos": 626 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 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"MGGNHRKPPRGKRPVSRRGRGGIWGSRQLLVGSRRRRVRLGTRSRRSLFNGVPDRAMEQVNELKEKGNKALSAGNIDDALQCYSEAIKLDPQNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKQTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRTKTLLADPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEVATPPPPPPPKKETKPEPMEEDLPENKKQALREKELGNEAYKKKDFDTALKHYDKAKDLDPTNMTYITNQAAVYFEKGDYGQCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSNCKEAADGYQRCVMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLIAIR", "length": 599, "header": "tr|A0A3Q1LW78-1|A0A3Q1LW78_BOVIN Isoform 1 of Stress-induced-phosphoprotein 1 OS=Bos taurus OX=9913 GN=STIP1 PE=4 SV=2 CANONICAL=A0A3Q1LW78-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LW78-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW78/entry", "sequence": { "sequence": "MGGNHRKPPRGKRPVSRRGRGGIWGSRQLLVGSRRRRVRLGTRSRRSLFNGVPDRAMEQVNELKEKGNKALSAGNIDDALQCYSEAIKLDPQNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKQTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRTKTLLADPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEVATPPPPPPPKKETKPEPMEEDLPENKKQALREKELGNEAYKKKDFDTALKHYDKAKDLDPTNMTYITNQAAVYFEKGDYGQCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSNCKEAADGYQRCVMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLIAIR", "length": 599, "header": "tr|A0A3Q1LW78-1|A0A3Q1LW78_BOVIN Isoform 1 of Stress-induced-phosphoprotein 1 OS=Bos taurus OX=9913 GN=STIP1 PE=4 SV=2 CANONICAL=A0A3Q1LW78-1" }, "locus": { "chromosome": "29", "start_pos": 42508467, "end_pos": 42496220, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076094.2", "url": 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CANONICAL=A0A3Q1LW78-1" }, "locus": { "chromosome": "29", "start_pos": 42508467, "end_pos": 42499908, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020809.5", "url": "https://www.ensembl.org/id/ENSBTAT00000020809.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020809.3", "url": "https://www.ensembl.org/id/ENSBTAP00000020809.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "dynein axonemal particle", "id": "GO:0120293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120293", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LW78", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW78" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 380, "end_pos": 382, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LW78-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 599, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LW78-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LW78" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LW78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW78" }, { "id": "SM00727", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00727" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "STI1", "eco_id": "ECO_0000259", "start_pos": 186, "end_pos": 225, "start_aa": "Met", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 314, "end_pos": 316 }, { "start_pos": 380, "end_pos": 382 }, { "start_pos": 99, "end_pos": 101 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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"count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LWA8-1", "uniprot_ac": "A0A3Q1LWA8", "uniprot_id": "A0A3Q1LWA8_BOVIN", "mass": { "chemical_mass": 293039.0, "monoisotopic_mass": 293039.0 }, "refseq": {}, "gene_names": [ { "name": "MYO9A", "type": "recommended", "evidence": [ { "id": "A0A3Q1LWA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ] } ], "protein_names": [ { 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Required for the regulation of neurite branching and motor neuron axon guidance.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8#function" }, { "database": "UniProtKB", "id": "ARBA00094197", "url": "https://www.uniprot.org/uniprotkb/ARBA00094197#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYO9A", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8", "locus": { "chromosome": "10", "start_pos": 18676350, "end_pos": 19061296, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007433", "url": "https://www.ensembl.org/id/ENSBTAG00000007433" } ] } } ], "crossref": [ { "id": "ENSBTAG00000007433", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007433", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01385", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01385", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04377", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04377", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17216", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17216", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20883", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20883", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000159", "url": 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"OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46184", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46184", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46184:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46184:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00063", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00063", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00130", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00130", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00612", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00612", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00788", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00788", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWA8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"length": 2549, "header": "tr|A0A3Q1LWA8-1|A0A3Q1LWA8_BOVIN Isoform 1 of Unconventional myosin-IXa OS=Bos taurus OX=9913 GN=MYO9A PE=3 SV=2 CANONICAL=A0A3Q1LWA8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWA8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8/entry", "sequence": { "sequence": "MNINDGGRRRFEDNEHTLRIYPGTISEETIYCPIPARKNSTAAEVIDSLINKLHLDKTKCYVLAEVKEFGGEEWILNPTDCPVQRMMLWPRMALENRLSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIAINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEEERLAFHLKQPEEYHYLNQITKKPLRQSWDDYCFDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNICYKKKTYRDDSIDICNPEVLPVVSELLEVKEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALMNSKDLEQNTKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEENSYIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAIFRWSVLRAFFRAMVAFREAGKRHIQRKTGHDDTAPCAVLKSMDSISFLQHPVHQRSLEILQRCKEEKYNITRKNPRTPLSDLQGMNTLNEKNQHETFDFAWNGRTGIRQSKLSSNTSLLDKDGIFANSASSKLLERAHGILTRNKNFKSKPGLPKHLLEVKSLKHLTSLTIQDRITKSLLHLHKKKKPPSISAQFQVSLSKLMETLGQAEPYFVKCIRSNAEKLPLRFNDALVLRQLRYTGMLETVRIRQSGYSCKYSFQDFVSHFHVLLPRNIIPSKFNIQDFFRKINLNPDNYQVGKSMVFLKEQERQHLQDLLHQEVLRRIVLLQRWFRVLLCRQHFLHLRQASIVIQQFWRNYVHQKQVRDAAVQKDALLMASAATLLQASWRAHVQRQRYLELRTATVVIQRRWREHCRRRHLAAVCIQARWKGYRESKRYQEQRNKIILLQSLCRGFRARQRFKSLKEQKVKEAKLELGLASIKPYGTLEIHGSDPSKWEDCSFDSRVKAIEECKSVIESNRISHESSMDCLNESPNKRQERARSQSGVDLQENVIVRERPKSLEDLHQKKVSRAKRESRRMRELEQAIFSLELLKVRSLGGVSPSEERRWSTELMPEGLQSLQGTPDSESSQGSLELLSCEESQKSKPEPVILDERDLPFVPPEVSHSPDFDPQDYSLSAASETNYTVHLKNGAMKEKLVCSSESITCKPQLRDPFVSNSLPTFFYIPHQDPLKMSSQLDTSVKRSKRLESEETLPSLTLDISREAGKYHLPGENQVVASLNIDSSNTVLKKLEKLNTEKEERQKQLQQQNEKEMMKQIRRQKDILEKERKAFKTIEKPRTGESFLIPSFHQSKQRIERPSSLLILKTPNKDEEPSMVGTPSVTIKDSVLAPKDSPSAHLPLKDRPVTLFFERKGGPGQSHTVKELSKTDGMSTQLNVACKHSHSRISKREHLRPAHPCSHKSDDPFRDGATKAIFFTPKENMSSSLVTTEALNSGNPQLQKQDEPTWKPVKLTGPGQGETSQRFSSVDEEAKLHKTMSQGEITKLAVRQKASDSDIRPQRAKMRFWAKGKQGEKKTSRVKPDTHSEVSALFAGSDMIPAHRFPDELSHNHPTPPLSPELPGSCRKEFKENKEPSPKARRKRSVKISSVALESVHWQNDSVQIIASASDLKSMDEFLLKKMNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSFYSSALAVDDGKSIRYKDLYALFEQILEKTMRLEQRDWSESPVRVWVNTFKVFLDEYMNEFKTLEYIPTKVPKTERKKRRKKESDLVEEHNGHIFKATQYSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVELSRLTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAENVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTIDPLQSVQDISKTTTCVELIVVEQMNKYKARLKDISSLEFAENKAKTRLSLIRRSMGKGRLRRGNYPCPSSPAVVRLPSMSDVTEETLTSEVALETDITEQQQAAMQQEERVLTEQIENLQKEKEELTFEMLVLEPRASDDETLESEASIGTADSSENLNIESEGAISEKSERSLALISMKAAGKSEPSSKLRKQLKKQQDSLDSVDSSVSSLCSSGTASSHGTRRRFQIYSKSPFYRASSAGEALGMEGPSGQTKSLEDKPQFISRGTFNPEKGKQKLKNVKNSPQKTKETPEGIVVSSRRKTVDPDCSSAQQLALFGNNEFMV", "length": 2549, "header": "tr|A0A3Q1LWA8-1|A0A3Q1LWA8_BOVIN Isoform 1 of Unconventional myosin-IXa OS=Bos taurus OX=9913 GN=MYO9A PE=3 SV=2 CANONICAL=A0A3Q1LWA8-1" }, "locus": { "chromosome": "10", "start_pos": 19002748, "end_pos": 18677354, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066617.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066617.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064983.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064983.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 477, "start_aa": "Thr", "end_pos": 477, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr477", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ], "pmid": "" }, { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ], "pmid": "" }, { "name": "microfilament motor activity", "id": "GO:0000146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000146", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ], "pmid": "" }, { "name": "growth cone", "id": "GO:0030426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ], "pmid": "" }, { "name": "myosin complex", "id": "GO:0016459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016459", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell junction assembly", "id": "GO:0034329", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034329", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ], "pmid": "" }, { "name": "establishment of epithelial cell apical/basal polarity", "id": "GO:0045198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045198", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWA8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1228, "end_pos": 1230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1381, "end_pos": 1383, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1678, "end_pos": 1680, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1854, "end_pos": 1856, "annotation": "n_glycosylation_sequon" }, { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 546, "end_pos": 548, "annotation": "n_glycosylation_sequon" }, { "start_pos": 621, "end_pos": 623, "annotation": "n_glycosylation_sequon" }, { "start_pos": 768, "end_pos": 770, "annotation": "n_glycosylation_sequon" }, { "start_pos": 814, "end_pos": 816, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LWA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWA8" }, { "id": "PS51456", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51456" } ], "ann_type": 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"https://www.ensembl.org/id/ENSBTAG00000018237" } ] } } ], "crossref": [ { "id": "A0A3Q1LWJ2", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LWJ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018237", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018237", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001609", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001609", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEIDQCLLESLPLGQRQRLVKRMRCEQVKAYYEREKAFQKQEGLLKKLKHGKNQKVHFNLADMIQDAIIHHDDKEVLRLLKEGADPHMPVSSGGSLLHLCARYDNVFIAEILIDRGANVNHQDEDFWTPMHIACACDNPDVVLLLILAGANVLLQDVNGNIPLDYATEGTDSSSILLTYLDENGVDLTSLRQMKLQRPVSMLTDVKHFLSCGGNVNERNDDGVTLLHMACASGYKEVVSLLLEHGGDLNAADNQHWTPLHLAAKYGQANLVKLLLMHQANPHLLNCHEEKASDVAASELIEEMLLKAESAWEGKPQASLCVQTLAQEDPYEEIVPDLPVLPSKLSPLVLPIAKQDSLLEKDIMFKDATKGLCKRQSQDSTVENTPMHGPAKPEQVKLMPPAPNDDLATLSELTDSSLLYEIQKRFGNNQIYTFIGDILLLVNPFKEIPIYSTVVSELYLSSTGQPNPSLPPHIFCCAERAFHQLFQERRPQCFVLSGERGSGKSEASKQIMRHLTCRSGSSRPIFDSKLKHVMSILEAFGHARTTLNDLSSCFIKYFELQFCERKKHLTGARIFTYMLEKSRLVSQPPGQSNFLIFYLLMDGLSAEEKYGLHLNNLHAHRYLRQTLREDISAAEHSLNREKFAVLKQALNVIGFSNLEVENLCVILAAVLHLGDVGFTAVSEADSALVSDLQLLEQVAGMLQVSPDELASALTTDIQYFKGEVTTRRHTVAMAEFYRDLLAKSLYSRLFSFLVNAVNCRLRSDEEPSSSQTWGIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLQEQAECVQEGVTMETAYSLGNQTGVLDFFFQKPSGFLSLLDEESQMIWSVEPSLPKKLHGLLESSNTNAVYSPVKDGNGNLALRDQGAAFTVMHYAGRVMYEAVGAIEKNKDSLSQNLLFVMKNYRYI", "length": 940, "header": "tr|A0A3Q1LWJ2-1|A0A3Q1LWJ2_BOVIN Isoform 1 of Unconventional myosin-XVI OS=Bos taurus OX=9913 GN=MYO16 PE=3 SV=2 CANONICAL=A0A3Q1LWJ2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWJ2/entry", "sequence": { "sequence": "MEIDQCLLESLPLGQRQRLVKRMRCEQVKAYYEREKAFQKQEGLLKKLKHGKNQKVHFNLADMIQDAIIHHDDKEVLRLLKEGADPHMPVSSGGSLLHLCARYDNVFIAEILIDRGANVNHQDEDFWTPMHIACACDNPDVVLLLILAGANVLLQDVNGNIPLDYATEGTDSSSILLTYLDENGVDLTSLRQMKLQRPVSMLTDVKHFLSCGGNVNERNDDGVTLLHMACASGYKEVVSLLLEHGGDLNAADNQHWTPLHLAAKYGQANLVKLLLMHQANPHLLNCHEEKASDVAASELIEEMLLKAESAWEGKPQASLCVQTLAQEDPYEEIVPDLPVLPSKLSPLVLPIAKQDSLLEKDIMFKDATKGLCKRQSQDSTVENTPMHGPAKPEQVKLMPPAPNDDLATLSELTDSSLLYEIQKRFGNNQIYTFIGDILLLVNPFKEIPIYSTVVSELYLSSTGQPNPSLPPHIFCCAERAFHQLFQERRPQCFVLSGERGSGKSEASKQIMRHLTCRSGSSRPIFDSKLKHVMSILEAFGHARTTLNDLSSCFIKYFELQFCERKKHLTGARIFTYMLEKSRLVSQPPGQSNFLIFYLLMDGLSAEEKYGLHLNNLHAHRYLRQTLREDISAAEHSLNREKFAVLKQALNVIGFSNLEVENLCVILAAVLHLGDVGFTAVSEADSALVSDLQLLEQVAGMLQVSPDELASALTTDIQYFKGEVTTRRHTVAMAEFYRDLLAKSLYSRLFSFLVNAVNCRLRSDEEPSSSQTWGIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLQEQAECVQEGVTMETAYSLGNQTGVLDFFFQKPSGFLSLLDEESQMIWSVEPSLPKKLHGLLESSNTNAVYSPVKDGNGNLALRDQGAAFTVMHYAGRVMYEAVGAIEKNKDSLSQNLLFVMKNYRYI", "length": 940, "header": "tr|A0A3Q1LWJ2-1|A0A3Q1LWJ2_BOVIN Isoform 1 of Unconventional myosin-XVI OS=Bos taurus OX=9913 GN=MYO16 PE=3 SV=2 CANONICAL=A0A3Q1LWJ2-1" }, "locus": { "chromosome": "12", "start_pos": 84156165, "end_pos": 83907803, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068307.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068307.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061607.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061607.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWJ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWJ2" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWJ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWJ2" } ], "pmid": "" }, { "name": "cytoskeletal motor activity", "id": "GO:0003774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003774", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWJ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWJ2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWJ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWJ2" } ], "pmid": "" }, { "name": "myosin complex", "id": "GO:0016459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016459", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWJ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWJ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 796, "end_pos": 798, "annotation": "n_glycosylation_sequon" }, { "start_pos": 833, "end_pos": 835, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LWJ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 940, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LWJ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LWJ2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LWJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWJ2" }, { "id": "PS51456", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51456" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Myosin motor", "eco_id": 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[ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LWP2-1", "uniprot_ac": "A0A3Q1LWP2", "uniprot_id": "A0A3Q1LWP2_BOVIN", "mass": { "chemical_mass": 84343.0, "monoisotopic_mass": 84343.0 }, "refseq": { "ac": "XP_024835151", "name": "protein phosphatase 1 regulatory subunit 12C isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835151" }, "gene_names": [ { "name": "PPP1R12C", "type": "recommended", "evidence": [ { "id": "A0A3Q1LWP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP2" } ] }, { "name": "PPP1R12C", "type": "synonym", "evidence": [ { "id": "XP_024835151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835151" } ] } ], "protein_names": [ { "name": "Protein phosphatase 1 regulatory subunit", "type": "recommended", "evidence": [ { "id": "A0A3Q1LWP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP2/entry#names_and_taxonomy" } ] }, { "name": "protein phosphatase 1 regulatory subunit 12C isoform X3", "type": "synonym", "evidence": [ { "id": "XP_024835151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835151" } ] } ], "function": [ { "annotation": "Regulates myosin phosphatase activity.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP2#function" }, { "database": "UniProtKB", "id": "ARBA00055480", "url": "https://www.uniprot.org/uniprotkb/ARBA00055480#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPP1R12C", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP2", "locus": { "chromosome": "18", "start_pos": 62310500, "end_pos": 62291235, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017847", "url": "https://www.ensembl.org/id/ENSBTAG00000017847" } ] } } ], "crossref": [ { "id": "A0A3Q1LWP2", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LWP2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017847", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017847", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21945", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21945", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512431", "url": "https://www.ncbi.nlm.nih.gov/gene/512431", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051226", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051226", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWP2", "url": "https://www.orthodb.org/?gene=A0A3Q1LWP2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24179", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24179", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24179:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24179:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15898", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15898", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024835151", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835151", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWP2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWP2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDEDGPGAGPGAAAAAARERRREQLRQWGARAGAEPGPGERRARTVRFERAAEFLAACAGGDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEALLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEAAQSRGPEPQGPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGTPIRDEDEGEEAPSEPPPAECRALNGVSSPPPCSPGSPVTPEEAPFSRRFGLQKTGSSGALGPTDWRGAEGTPGAGLQRSASSSRLEGASTQGREPRLARVPPTPSQKVPEPSCPSEISRPPPPLGNSTPPPRTPEPESPVKPNVPVASAAPPADSRDRRRTYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPEAEKSSVQSLDPSRRPRVPGVESTDGPAQRAEAPDGQGQGPQAAREPRRVGKEWRGPAEGEEAEPAPADRSPETSTPEGDPSSRRQRDLNPDPEPEPDEPDGGFRKLYAELRSENERLREALTETTLQLAQLKVELERATQKQERFAERPALLELERFERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVISKLSK", "length": 782, "header": "tr|A0A3Q1LWP2-1|A0A3Q1LWP2_BOVIN Isoform 1 of Protein phosphatase 1 regulatory subunit OS=Bos taurus OX=9913 GN=PPP1R12C PE=4 SV=2 CANONICAL=A0A3Q1LWP2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWP2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP2/entry", "sequence": { "sequence": "MSDEDGPGAGPGAAAAAARERRREQLRQWGARAGAEPGPGERRARTVRFERAAEFLAACAGGDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEALLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEAAQSRGPEPQGPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGTPIRDEDEGEEAPSEPPPAECRALNGVSSPPPCSPGSPVTPEEAPFSRRFGLQKTGSSGALGPTDWRGAEGTPGAGLQRSASSSRLEGASTQGREPRLARVPPTPSQKVPEPSCPSEISRPPPPLGNSTPPPRTPEPESPVKPNVPVASAAPPADSRDRRRTYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPEAEKSSVQSLDPSRRPRVPGVESTDGPAQRAEAPDGQGQGPQAAREPRRVGKEWRGPAEGEEAEPAPADRSPETSTPEGDPSSRRQRDLNPDPEPEPDEPDGGFRKLYAELRSENERLREALTETTLQLAQLKVELERATQKQERFAERPALLELERFERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVISKLSK", "length": 782, "header": "tr|A0A3Q1LWP2-1|A0A3Q1LWP2_BOVIN Isoform 1 of Protein phosphatase 1 regulatory subunit OS=Bos taurus OX=9913 GN=PPP1R12C PE=4 SV=2 CANONICAL=A0A3Q1LWP2-1" }, "locus": { "chromosome": "18", "start_pos": 62309933, "end_pos": 62291434, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077989.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077989.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065121.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065121.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 442, "start_aa": "Thr", "end_pos": 442, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr442", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 474, "start_aa": "Thr", "end_pos": 474, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr474", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP2" } ], "pmid": "" }, { "name": "stress fiber", "id": "GO:0001725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP2" } ], "pmid": "" }, { "name": "phosphatase regulator activity", "id": "GO:0019208", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019208", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 497, "end_pos": 499, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LWP2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 782, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LWP2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LWP2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LWP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP2" }, { "id": "PF15898", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15898" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "cGMP-dependent protein kinase interacting", "eco_id": "ECO_0000259", "start_pos": 683, "end_pos": 782, "start_aa": "Phe", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 442, 474 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 497, "end_pos": 499 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LWP8-1", "uniprot_ac": "A0A3Q1LWP8", "uniprot_id": "A0A3Q1LWP8_BOVIN", "mass": { "chemical_mass": 140302.0, "monoisotopic_mass": 140302.0 }, "refseq": {}, "gene_names": [ { "name": "WDR35", "type": "recommended", "evidence": [ { "id": "A0A3Q1LWP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8" } ] } ], "protein_names": [ { "name": "WD repeat-containing protein 35", "type": "recommended", "evidence": [ { "id": "A0A3Q1LWP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. May promote CASP3 activation and TNF-stimulated apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8#function" }, { "database": "UniProtKB", "id": "ARBA00058990", "url": "https://www.uniprot.org/uniprotkb/ARBA00058990#function" }, { "database": "UniProtKB", "id": "A0A3Q1MG68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG68#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8", "locus": { "chromosome": "11", "start_pos": 78898662, "end_pos": 78846244, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051164", "url": "https://www.ensembl.org/id/ENSBTAG00000051164" } ] } } ], "crossref": [ { "id": "A0A3Q1LWP8", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LWP8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051164", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051164", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017233", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017233", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VWAMCWA", "url": "https://omabrowser.org/oma/group/VWAMCWA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12764", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12764", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12764:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12764:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23145", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23145", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23387", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23387", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23390", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23390", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24797", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24797", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25170", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25170", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25768", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25768", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5610787", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610787", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620924", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620924", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LWP8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWP8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MG68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MG68-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG68-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGQRRKCPFGAPDATGRQRLPGRRELPRAAGTRDLQLRRFPVAGFDCWGRPLGVSRMFFYLSKKVAMSNNVKLKCISWNKDQGFIACGGDDGLLRVLKLETQTDDTKLRGLAAPSNLSMNQTLEGHSGSVQIVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGVQLCHVAWSADSKALLFGMANGEIHIYDNQGNFMVKMKMNCLVNVTGAVSIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQIMRHENDQNPVLIDTGMYVVSIQWNHTGSVLAVAGSQKVITQDKDVNTVQFYTPFGEHLGTLMVPGKQMSALSWEGGGLKIALTVDSFIYFANIRPDYKWGYCSNTVVYAYTRRDRPEYCVTFWDTKNNDKYVKYVKSLISITTCGDFCILATKADENHPQEENEMETFGAMFVLVLCNSIGTPLDPKYIDLVPLFVTMTKTHVIAASKEAFYIWQYRVAKKLTALEINQITRSRKEGRERIYHVDDTPSGSLDGVLDYSKAIQGTRDPICAITASDKTLIVSRESGTFQRYSLPNVGLIQKYSLNCQAYQLSLNCNSSRLAVIDILGVLTFFDLDARVTDSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAVMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKNPEYPNKDYIINFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLHTAEQAFVRCKDYQGIKFVKRLGNLQSEPMKQAEVAAYFGRFEEAERMYLDMDRRDLAISLRLKLGDWFRVLQLLKTGSGDADDSLLEQAHNAIGDYFADRQKRLNAIQYYVQGRNQERLAECYYMLEDYVGLENLASSLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHNMKEIGSLLARYASHLLEKNKILDAIELYRKANYFYDAAKLMFKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQIKNAQRGKVKGKSSEATSALAGLLEEEVLSTSSRFTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPAVEIYSLLALCACASRAFGTCSKAFIKLESLETLSSEQKQQYEDLALEIFTKHTPKDNRKSELDGLLEGGEGKLPTCVATGSPITEYQFWMCSVCKHCVLAQEINNYNFCPLCHSAVG", "length": 1238, "header": "tr|A0A3Q1LWP8-1|A0A3Q1LWP8_BOVIN Isoform 1 of WD repeat-containing protein 35 OS=Bos taurus OX=9913 GN=WDR35 PE=4 SV=1 CANONICAL=A0A3Q1LWP8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWP8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8/entry", "sequence": { "sequence": "MRGQRRKCPFGAPDATGRQRLPGRRELPRAAGTRDLQLRRFPVAGFDCWGRPLGVSRMFFYLSKKVAMSNNVKLKCISWNKDQGFIACGGDDGLLRVLKLETQTDDTKLRGLAAPSNLSMNQTLEGHSGSVQIVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGVQLCHVAWSADSKALLFGMANGEIHIYDNQGNFMVKMKMNCLVNVTGAVSIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQIMRHENDQNPVLIDTGMYVVSIQWNHTGSVLAVAGSQKVITQDKDVNTVQFYTPFGEHLGTLMVPGKQMSALSWEGGGLKIALTVDSFIYFANIRPDYKWGYCSNTVVYAYTRRDRPEYCVTFWDTKNNDKYVKYVKSLISITTCGDFCILATKADENHPQEENEMETFGAMFVLVLCNSIGTPLDPKYIDLVPLFVTMTKTHVIAASKEAFYIWQYRVAKKLTALEINQITRSRKEGRERIYHVDDTPSGSLDGVLDYSKAIQGTRDPICAITASDKTLIVSRESGTFQRYSLPNVGLIQKYSLNCQAYQLSLNCNSSRLAVIDILGVLTFFDLDARVTDSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAVMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKNPEYPNKDYIINFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLHTAEQAFVRCKDYQGIKFVKRLGNLQSEPMKQAEVAAYFGRFEEAERMYLDMDRRDLAISLRLKLGDWFRVLQLLKTGSGDADDSLLEQAHNAIGDYFADRQKRLNAIQYYVQGRNQERLAECYYMLEDYVGLENLASSLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHNMKEIGSLLARYASHLLEKNKILDAIELYRKANYFYDAAKLMFKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQIKNAQRGKVKGKSSEATSALAGLLEEEVLSTSSRFTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPAVEIYSLLALCACASRAFGTCSKAFIKLESLETLSSEQKQQYEDLALEIFTKHTPKDNRKSELDGLLEGGEGKLPTCVATGSPITEYQFWMCSVCKHCVLAQEINNYNFCPLCHSAVG", "length": 1238, "header": "tr|A0A3Q1LWP8-1|A0A3Q1LWP8_BOVIN Isoform 1 of WD repeat-containing protein 35 OS=Bos taurus OX=9913 GN=WDR35 PE=4 SV=1 CANONICAL=A0A3Q1LWP8-1" }, "locus": { "chromosome": "11", "start_pos": 78897658, "end_pos": 78846443, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087269.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087269.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059882.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059882.1" } ] } }, { "isoform_ac": "A0A3Q1MG68-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MG68/entry", "sequence": { "sequence": "MRGQRRKCPFGAPDATGRQRLPGRRELPRAAGTRDLQLRRFPVAGFDCWGRPLGVSRMFFYLSKKVAMSNNVKLKCISWNKDQGFIACGGDDGLLRVLKLETQTDDTKLRGLAAPSNLSMNQTLEGHSGSVQIVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGVQLCHVAWSADSKALLFGMANGEIHIYDNQGNFMVKMKMNCLVNVTGAVSIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQIMRHENDQNPVLIDTGMYVVSIQWNHTGSVLAVAGSQKVITQDKDVNTVQFYTPFGEHLGTLMVPGKQMSALSWEGGGLKIALTVDSFIYFANIRPDYKWGYCSNTVVYAYTRRDRPEYCVTFWDTKNNDKYVKYVKSLISITTCGDFCILATKADENHPQFVLVLCNSIGTPLDPKYIDLVPLFVTMTKTHVIAASKEAFYIWQYRVAKKLTALEINQITRSRKEGRERIYHVDDTPSGSLDGVLDYSKAIQGTRDPICAITASDKTLIVSRESGTFQRYSLPNVGLIQKYSLNCQAYQLSLNCNSSRLAVIDILGVLTFFDLDARVTDSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAVMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKNPEYPNKDYIINFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLHTAEQAFVRCKDYQGIKFVKRLGNLQSEPMKQAEVAAYFGRFEEAERMYLDMDRRDLAISLRLKLGDWFRVLQLLKTGSGDADDSLLEQAHNAIGDYFADRQKRLNAIQYYVQGRNQERLAECYYMLEDYVGLENLASSLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHNMKEIGSLLARYASHLLEKNKILDAIELYRKANYFYDAAKLMFKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQIKNAQRGKVKGKSSEATSALAGLLEEEVLSTSSRFTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPAVEIYSLLALCACASRAFGTCSKAFIKLESLETLSSEQKQQYEDLALEIFTKHTPKDNRKSELDGLLEGGEGKLPTCVATGSPITEYQFWMCSVCKHCVLAQEINNYNFCPLCHSAVG", "length": 1227, "header": "tr|A0A3Q1MG68-1|A0A3Q1LWP8_BOVIN Computationally mapped isoform of WD repeat-containing protein 35 OS=Bos taurus OX=9913 GN=WDR35 PE=4 SV=1 CANONICAL=A0A3Q1LWP8-1" }, "locus": { "chromosome": "11", "start_pos": 78897658, "end_pos": 78846443, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073611.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073611.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070161.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070161.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5610787", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5610787", "resource": "Reactome", "description": "Hedgehog 'off' state" }, { "id": "R-BTA-5620924", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620924", "resource": "Reactome", "description": "Intraflagellar transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A481CAF3-1", "protein_name": "WD repeat-containing protein 35", "gene_name": "WDR35", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFFYLSKKISIPNNVKLKCISWNKDQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSNLSMNQTLEGHSGSVQVVTWNEQYQKLTTSDQNGLIIVWMLCRGSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLCHVAWSADSKILLFGMANGEIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQIMRHENDQNPVLVDTGMHVVSIQWNHTGSVLAVAGSQKASTQDKDANTVQFFTPFGEHLGTLKVPGKQMSALSWEGGGLKIALAVDSFIYLANIRPDYKWGYCSNTVVYAYTRPDRPEYCVIFWDTKNNEKYVKYVKSLLSITTCGDFCILATKADETHPQFVLVLCNSIGTPLDPKYIDIVPLFVTMTKTHVIAASKEAFYTWQYRVAKKLTALEINQIMWSRKEGRERIYHVDDTPSGSVDGVLDYSKAIQGTRDPICAITASDKTLIVSRESGTIQRYSLPNVGLIQKYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVIGELLNLERKDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKNPEHPNKDYIINFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLPTAEQAFVRCKDYQGIKFVKCLGNLQSESMKQAEVAAYFGRFEEAERMYLNMDRRDLAIGLRLKLGDWFRVLQLLKTGSGAADDSLLEQAHNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYEGLENLANSLPENHKLLPEIAQMFVRVGMCEQAVMAFLKCNQPKAAVDTCVHLNQWNKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFYDAAKLMFKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQVKNAQRGKVTGKSSEATSALAGLLEEDVLSTTSRFTDNAWRGAEAYHFFILAQRQLYEGYVDMALKTALHLKDYEDIIPAVEIYSLLALCACASRAFGTCSKAFVKLESLETLSSDQKQQYEELALEIFTKYTPKDNRKSELDSLLEGGEGKLPTCVATGSPITEYQFWMCNVCKHCVLAQEISNYNFCPLCHSSVG", "length": 1170 }, "evidence": [ { "id": "A0A3Q1LWP8", "url": "https://omabrowser.org/oma/group/A0A3Q1LWP8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M9Q9T9-1", "protein_name": "WD repeat-containing protein 35", "gene_name": "wdr35", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFIYLSKKIAIPNNTVLKCVSWNKDQGFIACGGEDGLLKVLKLETYTDDAKLKGLAAPSNLSMNQTLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGLKICIVYEDGAVIVGSVDGNRIWGKELKGTQLAHVAWSPDSKILLFGMANGEIHIYDNQGNFIMKMSMSCLANVTGALSIAGIHWYPGTEGYLEPECPCLAVCFTNGHCQVMRHESDDSPVIIETGMWNVASIQWNHCGSVLAIAGSLRNSGAEKEMNVVHFYTPFGEHLRTLKVPGKQMTAVSWEGGGLRIGLAVDSYIYFANIRPDYKWGYCSNTVVYAYTRPDRLEYSVVFWDTKNNERFVKYVKSLMSITTCGDFCILATKADDTHPQEDTEAEAGSAMYVLVLCNSIGTPQDSKYIDIDPLFVTMTKTHVIAASREAFYIWQYRVAKKLTALEINQVTKTRKEGRERVYHIDDSPSGTSDGTLNFAKAFTATRDPICCITASDKMLLVGRESGILQRYSLPNISLLQKYSLTSRPYQLSLNCNSSRLAIIDITGVLTFLDVETRGSMGDAEGGSTAGDPSKFERKDVWDMKWANDNPDLFSMMEKTRMYVFRNLDPEEPIQTSGFICHFEDLEIKSVLLDEIMRDPDVPNKDYLMNFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLKMAEQAFVRCRDYQGIEFVKRLSNLQSEAMKQAEVAAYFSRFEEAERMYLDMDRRDLAISLRIKLGDWFRVLQLLKTGSGDSDDALLEQAYNAIGDYFADRQKWLNAVQYYLQGRNQERLAECYYMLEDYDGLERLANSLPENHKLLPDIGQMFVTVGMCEQAVSAFLKCNQPKAAVDACVHLNQWNKAVELAKNHSMKEIGPLLSKYASHLLEKNKTLEAVELYRKAHHFLDAAKLMYKIAEEEAKKRTRPLRVKKLYVLAALLVEDFHTQIKSSQQSKTKGKKSEATSALAGLLEEDESSSDSRILDDAWRGAEAYHFFLLAQRQLYDGKVDAAMRTALHLRDYEDIIPAVEIYSLLAICSSANGAFGTCSRAFIKLESLETLTPDQRQLYEDLALEIFTKHSPRDTRQSQRDSLTEGPEGKLPTCIVTGRVISEYQFWMCSVCKHCALEQEITQQNFCPLCHSTVG", "length": 1184 }, "evidence": [ { "id": "A0A3Q1LWP8", "url": "https://omabrowser.org/oma/group/A0A3Q1LWP8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A9J7JVQ1-1", "protein_name": "WD repeat-containing protein 35", "gene_name": "Wdr35", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLETQTDDSKLRGLAAPSNLSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLCHVTWSADSKILLFGMANGEIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQIMRHENDQNPILIDTGMYVVGIQWNHIGSVLAVAGSQKVVTQDKDVNIVQFYTPFGEHLGTLKVPGKQMCSLSWEGGGLKIALAVDSFIYFANIRPDYKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNNEKYVKYVKSLISITTCGDFCILATKADENHPQFVLVLCNSIGTPLDPKYIDLVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDVPSGSVDGVFDYSKAIQGTRDPICAITASDKTLIVGRESGIIQRYSFPNVALIQKYSLDCRACQLSLNCNSSRLAIVDIAGVLTFFDLDTRVTDNAGQQVVGELLKLERKDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKNPEHPSKDYIMNFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLYMAQQAFVRCKDYQGIKFVKRLGNLQSESMKQAEIIAYFGRFEEAERMYLDMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQAHNAIGDYFADRQKWLNAVQYYLKGRNQERLAECYYMLEDYEGLENLANSLPENHKLLPEIAQMFVRVGMCEQAVSAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHSMKEIGSLLARYASHLLEKNKTLDAIELYRKASYFFDAAKLMYKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKNSEATSALAGLLEEEVLSTTSRFTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPSVEIYSLLALCACASRAFGTCSKAFIKLESLETLSAEQKQQYEDLALEIFTKHTPKDNRKSELNSLLEGGEGKLPTCIATGSPIIEYQFWVCKVCKHYVLAQEISNYNFCPLCHSSVE", "length": 1170 }, "evidence": [ { "id": "A0A3Q1LWP8", "url": "https://omabrowser.org/oma/group/A0A3Q1LWP8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A6N6J5-1", "protein_name": "WD repeat-containing protein 35", "gene_name": "Wdr35", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLETQTDDSKLRGLAAPSNLSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLCHVTWSADSKILLFGMANGEIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHIGSVLAVAGSQKVVTQDKDVNIVQFYTPFGEHLGTLKVPGKQMCSLSWEGGGLKIALAVDSFIYFANIRPDYKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNNEKYVKYVKSLISITTCGDFCILATKADENHPQFVLVLCNSIGTPLDPKYIDLVPLFVAMTKTHVIAASKEALYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDVPSGSVDGVFDYSKAIQGTRDPICAITASDKTLIVGRESGVIQRYSFPNVALIQKYSLDCRACQLSLNCNSSRLAIIDIAGVLTFFDLDTRVTDSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKNPEHPSKDYIMNFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLYTAQQAFVRCKDYQGIKFVKRLGNLQSESMKQAEVIAYFGRFEEAERMYLDMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQAHNAIGDYFADRQKWMNAVQYYVKGRNQERLAECYYMLEDYEGLENLANSLPENHKLLPEIAQMFVRVGMCEQAVSAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHSMKEIGSLLARYASHLLEKNKTLDAIELYRKASYFFDAAKLMYKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKNSEATSALAGLLEEEVLSTTSRFTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPSVEIYSLLALCACASRAFGTCSKAFIKLESLETLSAEQKQQYEDLALEIFTKHTPKDNRKSELNSLLEGGEGKLPTCIATGSPIIEYQFWVCKVCKHYVLAQEISNYNFCPLCHSSVE", "length": 1170 }, "evidence": [ { "id": "A0A3Q1LWP8", "url": "https://omabrowser.org/oma/group/A0A3Q1LWP8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1C3E9-1", "protein_name": "WD repeat-containing protein 35", "gene_name": "WDR35", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MFIYLCKKIAIPGNVRLRCISWNKDEGFIACGGEDGLLKVLKLETQSDEAKIKGLAAPSNLSMNQTLEGHSGSVQVVTWNEQYHKLTTSDQNGLIIVWIIYKGAWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGTHLCHVAWSSDSKVLLFGMANGEIHIYDSNGNFIVKMKLSCLVNLTGTFRIAGIHWYHGTEGYVEPDCPCLAICYENGRCQIMRDENDHNPVLIDTGMNVVCIQWNHCGSVLALAGSLKGTSPDKDVNVVQFYTPFGEHLRTLKVPGKQISALSWEGGGLKIALAVDSYIYFANIRPDYKWGYCSNTVVYAYTRPDRPEYCVIFWDTKNNEKYVKYVKSLISITTYGDFCVLATKADEDQPQEEHEMESFGATYVLVLCNSIGTPLDPKYIDIGPLFVTMTRTHVIAASKEAFYIWQYRVAKKLTAMEINQVARTRKEGRERIYHIDDTPSGSGDGHLDYSKAVEGTRDPICAITASDKILLVGRESGTIHRYSLPNVGIIQKYTLNCRAHQLSLNCNSSRVAIIDLSGVLTFFDLDARVTSSTGQQVIGEQLKLERRDVWDMKWAKDNPDLFAVMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKNPERPNKDYIINFEIRSLRDSRALIEEVGIEESSQFIEDNPHPRLWRLLAEAALQKLDLQTAEQAFVRCKDYQGIKFVKRLGNLQSESMKQAEVAAYFGRFEEAERMYLDMDRRDLAIGLRMKLGDWFRVLQLLKTGSGDSDDALLEQAHNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYMLEDYQGLENLANSLPENNKLLPDIAHMFVRVGMCEQAVSAFLKCNRPKDAVDTCVHLNQWNKAVELAKNHNMKEIGSLLARYATHLLEKNKILDAIELYRKANYFFEAAKLMFKIADEEAKKRTKPLRVKKLYVLSALLMEQCHEQMQNAQRGKVKGSETASALAGLLEEDVLSSTNRFADNAWRGAEAYHFFILAQRQLYKGSVDAALKTALHLRDYEDIIPAVEIYSLLAVCACANRAFDTCSKAFVKLESLETLSQEQRQQYEDLALEIFARHCPKNNKKTDLDDVLESGDGKLPVCVATGDPILEYRFWMCSVCKHCMKAKERSNYNFCPLCHCSA", "length": 1178 }, "evidence": [ { "id": "A0A3Q1LWP8", "url": "https://omabrowser.org/oma/group/A0A3Q1LWP8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8BND3-1", "protein_name": "WD repeat-containing protein 35", "gene_name": "Wdr35", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLETQTDDSKLRGLAAPSNLSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYKGSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLCHVTWSADSKILLFGMANGEIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHIGSVLAVAGSQKVVTQDKDINIVQFYTPFGEHLGTLKVPGKQMCSLSWEGGGLKIALAVDSFIYFANIRPDYKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNSEKYVKYVKSLISITTCGDFCILATKADENHPQEENEMETFGATFVLVLCNSIGTPLDPKYIDLVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRERIYHVDDVPSGSVDGVFDYSKAIQGTRDPICAITASDKTLIVGRESGVIQRYSFPNVALIQKYSLDCRACQLSLNCNSSRLAIIDIAGVLTFFDLDTRVTDSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPSKDYIMNFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLYTAQQAFVRCKDYQGIKFVKLLGNLQSESMKQAEVIAYFGRFEDAERMYQDMDRRDLAIGLRMKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGEYFADRQKWQNAVQYYVKGRNQERLAECYYMLEDYEGLETLANSLPENHKLLPEIAQMFVRVGMCEQAVSAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHSMKEIGSLLARYASHLLEKNKTLDAIELYRKASYFFDAAKLMYKIADEEAKKRTKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKNSEATSALAGLLEEEVLSTTSRFTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPSVEIYSLLALCACASRAFGTCSKAFIKLESLETLSAEQKQQYEDLALEIFTKHTPKDNRKSELNSLLEGGEGKLPTCIATGSPIIEYQFWVCKVCKHYVLAQEISNYNFCPLCHSSVE", "length": 1181 }, "evidence": [ { "id": "A0A3Q1LWP8", "url": "https://omabrowser.org/oma/group/A0A3Q1LWP8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P2L0-1", "protein_name": "WD repeat-containing protein 35", "gene_name": "WDR35", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"length": 1181 }, "evidence": [ { "id": "A0A3Q1LWP8", "url": "https://omabrowser.org/oma/group/A0A3Q1LWP8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W097-1", "protein_name": "WD repeat-containing protein 35", "gene_name": "Oseg4", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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"length": 1205 }, "evidence": [ { "id": "A0A3Q1LWP8", "url": "https://omabrowser.org/oma/group/A0A3Q1LWP8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8" } ], "pmid": "" }, { "name": "intraciliary transport particle A", "id": "GO:0030991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030991", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8" } ], "pmid": "" }, { "name": "protein localization to non-motile cilium", "id": "GO:0097499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097499", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8" } ], "pmid": "" }, { "name": "intraciliary retrograde transport", "id": "GO:0035721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035721", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWP8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 611, "end_pos": 613, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LWP8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1238, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LWP8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LWP8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LWP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8" }, { "id": "PF23390", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23390" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IFT121 second beta-propeller", "eco_id": "ECO_0000259", "start_pos": 394, "end_pos": 724, "start_aa": "Trp", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LWP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8" }, { "id": "PF25768", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25768" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IFT121-like TPR repeats", "eco_id": "ECO_0000259", "start_pos": 1078, "end_pos": 1177, 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"url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWP8" }, { "id": "PF23387", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23387" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IFT80/172/WDR35 TPR", "eco_id": "ECO_0000259", "start_pos": 755, "end_pos": 844, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 }, { "start_pos": 121, "end_pos": 123 }, { "start_pos": 171, "end_pos": 173 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 319, "end_pos": 321 }, { "start_pos": 611, "end_pos": 613 } ] }, "class_list": [], 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"total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LWS1-1", "uniprot_ac": "A0A3Q1LWS1", "uniprot_id": "A0A3Q1LWS1_BOVIN", "mass": { "chemical_mass": 57376.0, "monoisotopic_mass": 57376.0 }, "refseq": { "ac": "XP_059745341", "name": "glucose-6-phosphate exchanger SLC37A1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745341" }, "gene_names": [ { "name": "SLC37A1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LWS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS1" } ] }, { "name": "SLC37A1", "type": "synonym", "evidence": [ { "id": "XP_059745341", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745341" } ] } ], "protein_names": [ { "name": "Solute carrier family 37 member 1", "type": "synonym", "evidence": [ { "id": "A0A3Q1LWS1", "database": "UniProtKB", "url": 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May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWS1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS1#function" }, { "database": "UniProtKB", "id": "ARBA00024304", "url": "https://www.uniprot.org/uniprotkb/ARBA00024304#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWS1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC37A1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS1", "locus": { "chromosome": "1", "start_pos": 142873904, "end_pos": 142803414, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021286", "url": "https://www.ensembl.org/id/ENSBTAG00000021286" } ] } } 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"Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044740", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044740", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWS1", "url": "https://www.orthodb.org/?gene=A0A3Q1LWS1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43184", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43184", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43184:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43184:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059745341", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745341", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "71535", "url": "https://www.rhea-db.org/rhea/71535", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LWS1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWS1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQLPPGIRFIISFSRDQWYRAFIFILTFLLYASFHLSRKPISIVKGELHSYCTASNDGKVGFSSQSQKARDALAHQLPDNGTDCGWAPFDQDNYQQLLGALDYSFLCAYAIGMYLSGIIGERLPIRCYLTFGMLASGAFTALFGVGYFYNIHSFGFYVITQIINGLVQTTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGILCFLFLIEHPKDIACSSSPASHPRGYENGAHRFWPQKPVPAEERSKPLDPEMQRLLLSDGKHSGHQNHVVVLPADGGGGMAAISFTGALKIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDVKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYAFSSISRMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKSLKGNSHALATVTAIIDGTGSVGAALGPLLAGLISPSGWNNVFYMLMFADACALLFLVRLIHKELSCPGSATGNQVPFKEH", "length": 533, "header": "tr|A0A3Q1LWS1-1|A0A3Q1LWS1_BOVIN Isoform 1 of Solute carrier family 37 member 1 OS=Bos taurus OX=9913 GN=SLC37A1 PE=3 SV=2 CANONICAL=A0A3Q1LWS1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWS1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS1/entry", "sequence": { "sequence": "MAQLPPGIRFIISFSRDQWYRAFIFILTFLLYASFHLSRKPISIVKGELHSYCTASNDGKVGFSSQSQKARDALAHQLPDNGTDCGWAPFDQDNYQQLLGALDYSFLCAYAIGMYLSGIIGERLPIRCYLTFGMLASGAFTALFGVGYFYNIHSFGFYVITQIINGLVQTTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGILCFLFLIEHPKDIACSSSPASHPRGYENGAHRFWPQKPVPAEERSKPLDPEMQRLLLSDGKHSGHQNHVVVLPADGGGGMAAISFTGALKIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDVKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYAFSSISRMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKSLKGNSHALATVTAIIDGTGSVGAALGPLLAGLISPSGWNNVFYMLMFADACALLFLVRLIHKELSCPGSATGNQVPFKEH", "length": 533, "header": "tr|A0A3Q1LWS1-1|A0A3Q1LWS1_BOVIN Isoform 1 of Solute carrier family 37 member 1 OS=Bos taurus OX=9913 GN=SLC37A1 PE=3 SV=2 CANONICAL=A0A3Q1LWS1-1" }, "locus": { "chromosome": "1", "start_pos": 142873007, "end_pos": 142803551, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078051.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078051.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061687.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061687.2" } ] } }, { "isoform_ac": "A0AAA9SUP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUP0/entry", "sequence": { "sequence": "MAQLPPGIRFIISFSRDQWYRAFIFILTFLLYASFHLSRKPISIVKGELHSYCTASNDGKVGFSSQSQKARDALAHQLPDNGTDCGWAPFDQDNYQQLLGALDYSFLCAYAIGMYLSGIIGERLPIRCYLTFGMLASGAFTALFGVGYFYNIHSFGFYVITQIINGLVQTTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVAAMGILCFLFLIEHPKDIACSSSPASHPRGYENGAHRFWPQKPVPAEERSKPLDPEMQRLLLSDGKHSGHQNHVVVLPADGGGGMAAISFTGALKIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDVKKAGELSTLFDVGGIFALRFLLHQQNGAGSHHSHAAPQRGPGQRAVRTHHDCRVCRPGDAQKPEGKLPCPGHRDRHHRRNRICRSSAGPAAGRAHLPIRMEQRVLHAHVRRRLCLTVSGSPHTQGAELPRVGDRKPGSV", "length": 501, "header": "tr|A0AAA9SUP0-1|A0A3Q1LWS1_BOVIN Computationally mapped isoform of Solute carrier family 37 member 1 OS=Bos taurus OX=9913 GN=SLC37A1 PE=3 SV=1 CANONICAL=A0A3Q1LWS1-1" }, "locus": { "chromosome": "1", "start_pos": 142872997, "end_pos": 142803551, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131566.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131566.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087685.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087685.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWS1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS1" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWS1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "glucose 6-phosphate:phosphate antiporter activity", "id": "GO:0061513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061513", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWS1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS1" } ], "pmid": "" }, { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWS1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phosphate ion transmembrane transport", "id": "GO:0035435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035435", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWS1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "71535", "name": "", "equation": "D-glucose 6-phosphate(in) + phosphate(out) = D-glucose 6-phosphate(out) + phosphate(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "71535", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/71535" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LWS1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 533, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LWS1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LWS1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LWS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS1" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 27, "end_pos": 517, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 81, "end_pos": 83 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LWS9-1", "uniprot_ac": "A0A3Q1LWS9", "uniprot_id": "A0A3Q1LWS9_BOVIN", "mass": { "chemical_mass": 33565.0, "monoisotopic_mass": 33565.0 }, "refseq": { "ac": "XP_002699982", "name": "high mobility group nucleosome-binding domain-containing protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699982" }, "gene_names": [ { "name": "HMGN5", "type": "recommended", "evidence": [ { "id": "A0A3Q1LWS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS9" } ] }, { "name": "HMGN5", "type": "synonym", "evidence": [ { "id": "XP_002699982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699982" } ] } ], "protein_names": [ { "name": "High mobility group nucleosome binding domain 5", "type": "synonym", "evidence": [ { "id": "A0A3Q1LWS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS9/entry#names_and_taxonomy" } ] }, { "name": "high mobility group nucleosome-binding domain-containing protein 5", "type": "synonym", "evidence": [ { "id": "XP_002699982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699982" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HMGN5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS9", "locus": { "chromosome": "X", "start_pos": 71433090, "end_pos": 71422763, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001877", "url": "https://www.ensembl.org/id/ENSBTAG00000001877" } ] } } ], "crossref": [ { "id": "A0A3Q1LWS9", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LWS9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001877", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001877", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "767875", "url": "https://www.ncbi.nlm.nih.gov/gene/767875", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:767875", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767875", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ELECEKD", "url": "https://omabrowser.org/oma/group/ELECEKD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LWS9", "url": "https://www.orthodb.org/?gene=A0A3Q1LWS9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BA81", "url": "https://www.orthodb.org/?gene=E1BA81", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23145", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23145", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23145:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23145:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01101", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01101", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002699982", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699982", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWS9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA81", "url": "https://www.uniprot.org/uniprotkb/E1BA81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BA81-1", "url": "https://www.uniprot.org/uniprotkb/E1BA81-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPKRKPAGQGDMKQEPKRRSARLSALPVPIIPDLKSKRTSTPRKMKTKNDMMGKNTDASAKTIAETKKEDVKDYNNETAENGGAKIIEAPVPEREIEEIKEEKIEDIKEEGEEKKEAMAKDGKEDEKEDQKGDGDQNKEEVKGKDVEEDKDGKGKEDEKKDEDGKEEEDKKETGDGKEGKDKKGKGEDGKEEEDEKEKRDKKENEDGKGKGEDGKESEDGKDKRDGKKGEAGKKDEDRKRDDGGNEKEDEKKKKGKEKENGKEDGGDVKDESKAEIGKEIIKREEVKKEDGKKESQSIA", "length": 299, "header": "tr|A0A3Q1LWS9-1|A0A3Q1LWS9_BOVIN Isoform 1 of High mobility group nucleosome binding domain 5 OS=Bos taurus OX=9913 GN=HMGN5 PE=1 SV=1 CANONICAL=A0A3Q1LWS9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWS9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWS9/entry", "sequence": { "sequence": "MPKRKPAGQGDMKQEPKRRSARLSALPVPIIPDLKSKRTSTPRKMKTKNDMMGKNTDASAKTIAETKKEDVKDYNNETAENGGAKIIEAPVPEREIEEIKEEKIEDIKEEGEEKKEAMAKDGKEDEKEDQKGDGDQNKEEVKGKDVEEDKDGKGKEDEKKDEDGKEEEDKKETGDGKEGKDKKGKGEDGKEEEDEKEKRDKKENEDGKGKGEDGKESEDGKDKRDGKKGEAGKKDEDRKRDDGGNEKEDEKKKKGKEKENGKEDGGDVKDESKAEIGKEIIKREEVKKEDGKKESQSIA", "length": 299, "header": "tr|A0A3Q1LWS9-1|A0A3Q1LWS9_BOVIN Isoform 1 of High mobility group nucleosome binding domain 5 OS=Bos taurus OX=9913 GN=HMGN5 PE=1 SV=1 CANONICAL=A0A3Q1LWS9-1" }, "locus": { "chromosome": "X", "start_pos": 71432086, "end_pos": 71422899, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082587.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082587.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061898.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061898.1" } ] } }, { "isoform_ac": "E1BA81-1", "url": "https://www.uniprot.org/uniprotkb/E1BA81/entry", "sequence": { "sequence": "PKRRSARLSALPVPIIPDLKSKRTSTPRKMKTKNDMMGKNTDASAKTIAETKKEDVKDYNNETAENGGAKIIEAPVPEREIEEIKEEKIEDIKEEGEEKKEAMAKDGKEDEKEDQKGDGDQNKEEKGKGEDGKEEEDEKEKRDKKENEDGKGKGEDGK", "length": 158, "header": "tr|E1BA81-1|E1BA81_BOVIN Computationally mapped isoform of High mobility group nucleosome binding domain 5 OS=Bos taurus OX=9913 GN=HMGN5 PE=1 SV=2 CANONICAL=A0A3Q1LWS9-1" }, "locus": { "chromosome": "X", "start_pos": 71431834, "end_pos": 71425930, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053474.3", "url": "https://www.ensembl.org/id/ENSBTAT00000053474.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051689.2", "url": "https://www.ensembl.org/id/ENSBTAP00000051689.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:767875", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:767875", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A617-1", "protein_name": "High mobility group nucleosome binding domain 5", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPKRKAAGQGDMKQEPKRRSARLSALPVPTTLELKFKRTSTPRKMKSKNDMIEKNTDTSARATVETKKEVVKEEYNDETAENGEAKIIEEPAPEKEIEEIKEETVEDTKEERGEKKEAVAAEGKEDEKDEKGDGEDQNKKEEKGEDRKEDKDEKEDEGRKEKEDGKEEKDKKETGDEKEDEDGKRKGDEKEEEDEKERGDEKENENGKGKGEDGKKTEDGKYKGEYEKKGEDRKEKGDEKKDGDGKEDESENEKEDEKEKEDGKEEENEKEDEKDGGNGKEDENKAEIGKEIADKEEVKKEDEKKEVSQGIV", "length": 312 }, "evidence": [ { "id": "A0A3Q1LWS9", "url": "https://omabrowser.org/oma/group/A0A3Q1LWS9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P82970-1", "protein_name": "High mobility group nucleosome-binding domain-containing protein 5", "gene_name": "HMGN5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_015313956", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015313956", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWU7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWU7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWU7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAEMLLEPNRGSVTFEDVAVYFSWEEWALLDEAQRCLYHDVMLENFALTSSLGCWHGAEDKGAPSEKSISVEGVSQIKTLKADSCPQKGQPFEKCGPVLRDNFHLPEHQEAHLEQKPYTCGNQFYIAANLQQYQGQHIREIPIRTSVDTALIIKSCRTHLSGESFFSEGIRKDDLASMGFFHQPVTHTNENSNNSNECEAVFHSGERHQNWGEGKKILNCTDTLVEDQRVLTREGLYECSKCGKTSTRRWNLIQHQKVHTGERPYECHECGKSFTRSNSLKTHRKVHTGEKPYEYKECGKSFSQRSNLVQHQKGHSGERLHQCGECGKSFSRSSTLIHHRRLHTGERPYECSKCGKSFKQSSSLSSHQKIHTGERPYECRECGKSFSCKSNLIIHLRVHTGERPYECQECTKSFSCKSNLINHLRVHSGERPYDCAECGQSFTQRSILIQHQRIHTGERPYECHECGKSFSRKFSLIYHRKGHTGERPHQRKERGKSFNCKSNLNEHQKIHPGERSHESGDSGKSFSQSSSLIQH", "length": 536, "header": "tr|A0A3Q1LWU7-1|A0A3Q1LWU7_BOVIN Isoform 1 of Zinc finger protein 211 OS=Bos taurus OX=9913 GN=ZNF211 PE=3 SV=3 CANONICAL=A0A3Q1LWU7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWU7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWU7/entry", "sequence": { "sequence": 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"url": "https://www.ensembl.org/id/ENSBTAP00000065185.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWU7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWU7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWU7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWU7" } ], "pmid": 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ubiquitin transferase OS=Bos taurus OX=9913 GN=ZNF598 PE=3 SV=2 CANONICAL=A0A3Q1LWW3-1" }, "locus": { "chromosome": "25", "start_pos": 1561601, "end_pos": 1551314, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083326.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083326.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065206.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065206.2" } ] } }, { "isoform_ac": "E1B928-1", "url": "https://www.uniprot.org/uniprotkb/E1B928/entry", "sequence": { "sequence": "MAAAAAAGPEGRLVSQEAAAAAPERGGGSCVLCCGDLEATALGRCDHPVCYRCSTKMRVLCEQRYCAVCREELRQVVFGKTLPAFATIPLHQLQHEKKYDIYFMDGRVFALYRQLLQHECPRCPERPPFSLFGDLEQHMRKQHELFCCKLCLRHLQIFTHERKWYSRKDLARHRMQGDPDDTSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCDADGAQDYYSDYAYLREHFREKHFLCEEGRCSTEQFTHAFRTEIDLKAHRTACHSRSRAEARQNRQIDLQFSYAPRHSRRSEGVIGGEDYEELDRYNRQGRTGRASGRGAQQSRRGSWRYKREEEDREVAAAIRASVATQQQQQQQETRRSEDWEEGGRPKKEEAGLRGPEEARGPRRPARTPGEGPGPKEASTNGPVSQEAFSITGPAAGATLPNTLPPPTSKLKDEDFPSLCASSSSSSSVAAAPGPVGLALAYPVPARGRTTFQEEDFPALVPSASKPSSAPTSLISAWNSGASKKVAHPAPGSQSTSGGSQPPRKSGKGGKGGKKGGPPPTEEAEEDGRAGLTAQELRSVPTTVAVSSLLAGATTHTFTKVGKKKKVGSEKSGAASPPPTDKEGPPGAELAPTAPPGRAEGPAAVIVNGHSEGPAPVRSTPKEPPGLPRPLGPPPCPTPQEDFPALCGPCPPRMPPPPGFNAVVLLKGTPPPPGLAPPVSKPPPGFSGLPSSPHPACVPSTTTTTKAPRPTPVPRAYLVPENFRERNLQLIQSIRDFLQSDDARFSKFKSYSGEFRQGAISAAQYYKSCRDLLGENFEKIFNELLVLLPDTAKQQELLLAHTDFRGREKPPGTKAKKNRKSAWQASTRQADSEATCSGPSAGRLSGDHREGPPRLAGTPSWGIPLEASWKLERPLPQQQAALGLRSQALEGAGEGRGRCRDLCALSGLVATVAPSRSP", "length": 949, "header": "tr|E1B928-1|E1B928_BOVIN Computationally mapped isoform of RING-type E3 ubiquitin transferase OS=Bos taurus OX=9913 GN=ZNF598 PE=3 SV=4 CANONICAL=A0A3Q1LWW3-1" }, "locus": { "chromosome": "25", "start_pos": 1561601, "end_pos": 1550967, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001356.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001356.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001356.7", "url": "https://www.ensembl.org/id/ENSBTAP00000001356.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 669, "start_aa": "Thr", "end_pos": 669, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr669", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 742, "start_aa": "Thr", "end_pos": 742, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr742", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:505086", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505086", "resource": "KEGG Pathway" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rescue of stalled ribosome", "id": "GO:0072344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072344", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW3" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW3" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW3" } ], "pmid": "" }, { "name": "ribosome binding", "id": "GO:0043022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043022", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-9948301", "name": "ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3T169-1", "Q1RMX2-1", "Q2TA10-1", "A0A3Q1LWW3-1" ], "evidence": [ { "id": "R-BTA-9948301", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9948301" } ] }, { "id": "R-BTA-9948317", "name": "ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3T169-1", "Q1RMX2-1", "Q2TA10-1", "A0A3Q1LWW3-1" ], "evidence": [ { "id": "R-BTA-9948317", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9948317" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LWW3", "gene_name": "ZNF598", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LWW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LWW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW3" } ] } ] }, { "uniprot_ac": "Q1RMX2", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": 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}, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LWW8-1", "uniprot_ac": "A0A3Q1LWW8", "uniprot_id": "A0A3Q1LWW8_BOVIN", "mass": { "chemical_mass": 113202.0, "monoisotopic_mass": 113202.0 }, "refseq": {}, "gene_names": [ { "name": "LOC112441535", "type": "recommended", "evidence": [ { "id": "A0A3Q1LWW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ] } ], "protein_names": [ { "name": "Phospholipid-transporting ATPase", "type": "recommended", "evidence": [ { "id": "A0A3Q1LWW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.1", "type": "synonym", "evidence": [ { "id": "A0A3Q1LWW8", "database": 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Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages. Required for B cell differentiation past the pro-B cell stage. Seems to mediate PS flipping in pro-B cells. May be involved in the transport of cholestatic bile acids.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8#function" }, { "database": "UniProtKB", "id": "ARBA00058591", "url": "https://www.uniprot.org/uniprotkb/ARBA00058591#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112441535", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8", "locus": {} } ], "crossref": [ { "id": "A0A3Q1LWW8", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LWW8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054134", "url": 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Classification" ] }, { "id": "IPR023298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059000", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059000", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24092", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24092:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00122", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00122", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13246", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16209", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16209", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16212", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16212", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "38567", "url": "https://www.rhea-db.org/rhea/38567", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "66132", "url": "https://www.rhea-db.org/rhea/66132", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LWW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWW8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "IVDHSINRGKEKRVGTIISSKYTLWNFLPKNLFEQFRRIANFYFLIIFLYSPITSGLPLFFVITVTAIKQGYEDWLRHRADNEVNKSTVYIIENAKRVKKESEKIKVGDIVEVQADETFPCDLILLSSCTVDGTCYVTTASLDGESNCKTHYAVRDTIELRTVESIDNLRAAIECEQPQPDLYKFVGRINIYSNSIEAVARSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQKRSAVEKSINAFLIVYLFILLTKAAICTTLKYVWQSTPHNDEPWYNQKTQKERETWKVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDNDFYDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENTMEFIECCIDGHKYKGVAQETDGLSQTDGPLPYLDRADKNREELFLRALCLCHTVEVKPNDTVDGVTESSELTYMSSSPDEIALVKGAKKYGFTFVGVQNGYMRVENQRKEIEEYELLHTLNFDAVRRRMSVIVKTQTGADSAVFPRVQNHEIDLIKVHVEHNAMEGYRTLCIAFKEIAPDDYERVNRQLIEAKMALQDREEKMEKVFDEIETDMHLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACQDRLHELLTEYRKKLLAWTEHQEYGLIIDGSTLSLILNSSQDSGSNNYKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGSPITLSIGDGANDVSMILESHVGIGKEGRQASRNSDYAVPKFKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSLPILAYSLLEQHINIDTLTSDPRLYMKISGNAMLQLGPFLYWTFLAAFEGTVFFFGTYFLFQTTSLDENGKVYGNWTFGTIIFTILVFTVTLKLALDTPFYVFFSFFWGGIIWPFLKQQRMYFVFAQMLSSVSVWLTIILLIFVSLSPRCSGLY", "length": 989, "header": "tr|A0A3Q1LWW8-1|A0A3Q1LWW8_BOVIN Isoform 1 of Phospholipid-transporting ATPase OS=Bos taurus OX=9913 GN=LOC112441535 PE=3 SV=2 CANONICAL=A0A3Q1LWW8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWW8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8/entry", "sequence": { "sequence": "IVDHSINRGKEKRVGTIISSKYTLWNFLPKNLFEQFRRIANFYFLIIFLYSPITSGLPLFFVITVTAIKQGYEDWLRHRADNEVNKSTVYIIENAKRVKKESEKIKVGDIVEVQADETFPCDLILLSSCTVDGTCYVTTASLDGESNCKTHYAVRDTIELRTVESIDNLRAAIECEQPQPDLYKFVGRINIYSNSIEAVARSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQKRSAVEKSINAFLIVYLFILLTKAAICTTLKYVWQSTPHNDEPWYNQKTQKERETWKVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDNDFYDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENTMEFIECCIDGHKYKGVAQETDGLSQTDGPLPYLDRADKNREELFLRALCLCHTVEVKPNDTVDGVTESSELTYMSSSPDEIALVKGAKKYGFTFVGVQNGYMRVENQRKEIEEYELLHTLNFDAVRRRMSVIVKTQTGADSAVFPRVQNHEIDLIKVHVEHNAMEGYRTLCIAFKEIAPDDYERVNRQLIEAKMALQDREEKMEKVFDEIETDMHLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACQDRLHELLTEYRKKLLAWTEHQEYGLIIDGSTLSLILNSSQDSGSNNYKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGSPITLSIGDGANDVSMILESHVGIGKEGRQASRNSDYAVPKFKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSLPILAYSLLEQHINIDTLTSDPRLYMKISGNAMLQLGPFLYWTFLAAFEGTVFFFGTYFLFQTTSLDENGKVYGNWTFGTIIFTILVFTVTLKLALDTPFYVFFSFFWGGIIWPFLKQQRMYFVFAQMLSSVSVWLTIILLIFVSLSPRCSGLY", "length": 989, "header": "tr|A0A3Q1LWW8-1|A0A3Q1LWW8_BOVIN Isoform 1 of Phospholipid-transporting ATPase OS=Bos taurus OX=9913 GN=LOC112441535 PE=3 SV=2 CANONICAL=A0A3Q1LWW8-1" }, "locus": { "chromosome": "NKLS02002208.1", "start_pos": 5341714, "end_pos": 5258728, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067287.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067287.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061944.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061944.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ], "pmid": "" }, { "name": "ATPase-coupled intramembrane lipid transporter activity", "id": "GO:0140326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140326", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phospholipid translocation", "id": "GO:0045332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045332", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWW8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 441, "end_pos": 443, "annotation": "n_glycosylation_sequon" }, { "start_pos": 682, "end_pos": 684, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" }, { "start_pos": 910, "end_pos": 912, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "38567", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "C7EXK4-1", "Q29449-1", "A0AAA9SM02-1", "A0A3Q1LM90-1", "A0AAA9RSX8-1", "A0A3Q1MQL3-1", "E1BPC3-1", "A0A3Q1M9T8-1", "A0A3Q1LWW8-1", "F1N0B2-1" ], "evidence": [ { "id": "38567", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38567" } ] }, { "id": "66132", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MWM0-1", "A0A3Q1LM90-1", "A0AAA9RSX8-1", "A0A3Q1M9T8-1", "A0A3Q1LWW8-1" ], "evidence": [ { "id": "66132", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66132" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LM90", "gene_name": "ATP11B", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A3Q1LM90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM90" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A3Q1LM90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM90" } ] } ] }, { "uniprot_ac": "A0A3Q1LWW8", "gene_name": "LOC112441535", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A3Q1LWW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A3Q1LWW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWW8" } ] } ] }, { "uniprot_ac": "A0A3Q1M9T8", "gene_name": "ATP11A", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A3Q1M9T8", "database": "UniProtKB", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWX7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWX7" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "id": "GO:0016705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016705", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWX7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWX7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ceramide biosynthetic process", "id": "GO:0046513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046513", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWX7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWX7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWX7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWX7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LWX7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 531, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LWX7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LWX7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, 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"url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LX20", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025211", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025211", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15584", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15584", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16860", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16860", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513047", "url": "https://www.ncbi.nlm.nih.gov/gene/513047", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028643", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028643", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028651", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028651", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MREQGNQ", "url": "https://omabrowser.org/oma/group/MREQGNQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10333:SF85", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10333:SF85", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12998", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12998", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LN25", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LN25-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LX20", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LX20-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0T5", "url": "https://www.uniprot.org/uniprotkb/F1N0T5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0T5-1", "url": "https://www.uniprot.org/uniprotkb/F1N0T5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSPANGEQIHLVNYVEDYLDSIESLPFDLQRNVSLMREIDAKYQEILKELDEYYERFKREADGAQKRRALHCIQRALIRSQELGDEKIQLVSQMVELVENRARQVDSHVELLEAQQEAADATGHSKAGQDKSKNEAIAQAEKPNNKRSRRQRNNENRENAANNHDHDDVTSGTPKEKKAKASKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLSHKPKGKWYCPKCRGESEKTMDKALEKSKRERAYNR", "length": 278, "header": "tr|A0A3Q1LX20-1|A0A3Q1LX20_BOVIN Isoform 1 of Inhibitor of growth protein OS=Bos taurus OX=9913 GN=ING1 PE=3 SV=1 CANONICAL=A0A3Q1LX20-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LN25-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN25/entry", "sequence": { "sequence": "MEGGKGPRLREKPPRDLRLKAGPTPLWVVFRSGGADIKSGIQATGEKGRPASPGARRGFTSRASLSPSRLAPASSRRHNKGGRCWTAQAREPRGPLGVVVRPPDEILKELDEYYERFKREADGAQKRRALHCIQRALIRSQELGDEKIQLVSQMVELVENRARQVDSHVELLEAQQEAADATGHSKAGQDKSKNEAIAQAEKPNNKRSRRQRNNENRENAANNHDHDDVTSGTPKEKKAKASKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLSHKPKGKWYCPKCRGESEKTMDKALEKSKRERAYNR", "length": 337, "header": "tr|A0A3Q1LN25-1|A0A3Q1LN25_BOVIN Computationally mapped isoform of Inhibitor of growth protein OS=Bos taurus OX=9913 GN=ING1 PE=3 SV=1 CANONICAL=A0A3Q1LX20-1" }, "locus": { "chromosome": "12", "start_pos": 85268945, "end_pos": 85262891, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086454.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086454.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058165.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058165.1" } ] } }, { "isoform_ac": "A0A3Q1LX20-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX20/entry", "sequence": { "sequence": "MLSPANGEQIHLVNYVEDYLDSIESLPFDLQRNVSLMREIDAKYQEILKELDEYYERFKREADGAQKRRALHCIQRALIRSQELGDEKIQLVSQMVELVENRARQVDSHVELLEAQQEAADATGHSKAGQDKSKNEAIAQAEKPNNKRSRRQRNNENRENAANNHDHDDVTSGTPKEKKAKASKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLSHKPKGKWYCPKCRGESEKTMDKALEKSKRERAYNR", "length": 278, "header": "tr|A0A3Q1LX20-1|A0A3Q1LX20_BOVIN Isoform 1 of Inhibitor of growth protein OS=Bos taurus OX=9913 GN=ING1 PE=3 SV=1 CANONICAL=A0A3Q1LX20-1" }, "locus": { "chromosome": "12", "start_pos": 85268945, "end_pos": 85264198, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084135.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084135.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060037.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060037.1" } ] } }, { "isoform_ac": "F1N0T5-1", "url": "https://www.uniprot.org/uniprotkb/F1N0T5/entry", "sequence": { "sequence": "MAAPGGQRETGVRAAGPARVQSGLPPGPWGPRERRRQILKELDEYYERFKREADGAQKRRALHCIQRALIRSQELGDEKIQLVSQMVELVENRARQVDSHVELLEAQQEAADATGHSKAGQDKSKNEAIAQAEKPNNKRSRRQRNNENRENAANNHDHDDVTSGTPKEKKAKASKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLSHKPKGKWYCPKCRGESEKTMDKALEKSKRERAYNR", "length": 269, "header": "tr|F1N0T5-1|A0A3Q1LX20_BOVIN Computationally mapped isoform of Inhibitor of growth protein OS=Bos taurus OX=9913 GN=ING1 PE=3 SV=2 CANONICAL=A0A3Q1LX20-1" }, "locus": { "chromosome": "12", "start_pos": 85268945, "end_pos": 85265814, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035341.7", "url": "https://www.ensembl.org/id/ENSBTAT00000035341.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035217.5", "url": "https://www.ensembl.org/id/ENSBTAP00000035217.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q9QXV3-1", "protein_name": "Inhibitor of growth protein 1", "gene_name": "Ing1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSPANGEQIHLVNYVEDYLDSIESLPFDLQRNVSLMREIDAKYQEILKELDDYYEKFKRETDGTQKRRVLHCIQRALIRSQELGDEKIQIVSQMVELVENRSRQVDSHVELFEAHQDISDGTGGSGKAGQDKSKSEAITQADKPNNKRSRRQRNNENRENASNNHDHDDITSGTPKEKKAKTSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGESEKTMDKALEKSKKERAYNR", "length": 279 }, "evidence": [ { "id": "A0A3Q1LX20", "url": "https://omabrowser.org/oma/group/A0A3Q1LX20/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UK53-1", "protein_name": "Inhibitor of growth protein 1", "gene_name": "ING1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSFVECPYHSPAERLVAEADEGGPSAITGMGLCFRCLLFSFSGRSGVEGGRVDLNVFGSLGLQPWIGSSRCWGGPCSSALRCGWFSSWPPPSKSAIPIGGGSRGAGRVSRWPPPHWLEAWRVSPLPLSPLSPATFGRGFIAVAVIPGLWARGRGCSSDRLPRPAGPARRQFQAASLLTRGWGRAWPWKQILKELDECYERFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIVSQMVELVENRTRQVDSHVELFEAQQELGDTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDHDDGASGTPKEKKAKTSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSKKERAYNR", "length": 422 }, "evidence": [ { "id": "A0A3Q1LX20", "url": "https://omabrowser.org/oma/group/A0A3Q1LX20/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VEF5-1", "protein_name": "Inhibitor of growth protein", "gene_name": "Dmel\\CG7379", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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Classification", "Other" ] }, { "id": "A0A3Q1LX62", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LX62-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX62-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLAKDLLHSSPEEEKRKCKKKCLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKERLTEGCSFRRKQH", "length": 84, "header": "tr|A0A3Q1LX62-1|A0A3Q1LX62_BOVIN Isoform 1 of 40S ribosomal protein S27 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0A3Q1LX62-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LX62-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX62/entry", "sequence": { "sequence": "MPLAKDLLHSSPEEEKRKCKKKCLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKERLTEGCSFRRKQH", "length": 84, "header": "tr|A0A3Q1LX62-1|A0A3Q1LX62_BOVIN Isoform 1 of 40S ribosomal protein S27 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0A3Q1LX62-1" }, "locus": { "chromosome": "X", "start_pos": 86675392, "end_pos": 86675141, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079109.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079109.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065325.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065325.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5Y7E5-1", "protein_name": "40S ribosomal protein S27-like", "gene_name": "ENSRNOG00000070133", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCAFGRPLAKDLLHPSPEEEKRKHKKKRLVQSPNAYFMDMKCPGFYKITTVFSHAQTGVLCVGCSTVLCQPTGGKTRLTEGCSFRRKQH", "length": 89 }, "evidence": [ { "id": "A0A3Q1LX62", "url": "https://omabrowser.org/oma/group/A0A3Q1LX62/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX62", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX62" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX62", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX62" } ], "pmid": "" }, { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX62", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX62" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX62", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX62" } ], "pmid": "" }, { "name": "ribosomal small subunit assembly", "id": "GO:0000028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000028", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX62", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX62" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosolic small ribosomal subunit", "id": "GO:0022627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022627", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX62", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX62" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LX62-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 84, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LX62-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LX62" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LX68-1", "uniprot_ac": "A0A3Q1LX68", "uniprot_id": "A0A3Q1LX68_BOVIN", "mass": { "chemical_mass": 51937.0, "monoisotopic_mass": 51937.0 }, "refseq": { "ac": "XP_005212203", "name": "forkhead box protein N3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212203" }, "gene_names": [ { "name": "FOXN3", "type": "recommended", "evidence": [ { "id": "A0A3Q1LX68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68" } ] }, { "name": "FOXN3", "type": "synonym", "evidence": [ { "id": "XP_005212203", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212203" } ] } ], "protein_names": [ { "name": "Forkhead box protein N3", "type": "recommended", "evidence": [ { "id": "A0A3Q1LX68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68/entry#names_and_taxonomy" } ] }, { "name": "Checkpoint suppressor 1", "type": "synonym", "evidence": [ { "id": "A0A3Q1LX68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68/entry#names_and_taxonomy" } ] }, { "name": "forkhead box protein N3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005212203", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212203" } ] } ], "function": [ { "annotation": "Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).", "evidence": [ { "database": "UniProtKB", "id": "G3MX01", "url": "https://www.uniprot.org/uniprotkb/G3MX01#function" }, { "database": "UniProtKB", "id": "ARBA00034657", "url": "https://www.uniprot.org/uniprotkb/ARBA00034657#function" }, { "database": "UniProtKB", "id": "A0A3Q1LX68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FOXN3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68", "locus": { "chromosome": "10", "start_pos": 100831725, "end_pos": 101243029, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046684", "url": "https://www.ensembl.org/id/ENSBTAG00000046684" } ] } } ], "crossref": [ { "id": "A0A3Q1LX68", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LX68", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046684", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046684", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20059", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20059", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505469", "url": "https://www.ncbi.nlm.nih.gov/gene/505469", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030456", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030456", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047119", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047119", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505469", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505469", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XSIGKGS", "url": "https://omabrowser.org/oma/group/XSIGKGS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LX68", "url": "https://www.orthodb.org/?gene=A0A3Q1LX68", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MX01", "url": "https://www.orthodb.org/?gene=G3MX01", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13962", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13962", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13962:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13962:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00250", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00250", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005212203", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212203", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LX68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LX68-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MX01", "url": "https://www.uniprot.org/uniprotkb/G3MX01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MX01-1", "url": "https://www.uniprot.org/uniprotkb/G3MX01-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPVMPPSKKPESSGISVSSGLSQCYRGSGFSKALQEDDDLDFPLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGDSVLRSVSPVQDPDDDPPPSPAHSDVPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPHSNVFNTPPASPQAYQSTSGPPLWPGSTFFKRNGALLQDPDIDAATAMMLLNTPPEIHAGFPPGVIQNGTRVLSRGLFPGVRPLPVTPIGMTAAVRNGLPGCRLRTESEPACGSPVVSGDPKEDHTYSSAKAAAARSASPASDCASSSSADEPDEVAAKGGPEGSEGSCPSRESHSEPEEDGRPRGPREAPGDGGPAHKKRPPAAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETAKN", "length": 480, "header": "tr|A0A3Q1LX68-1|A0A3Q1LX68_BOVIN Isoform 1 of Forkhead box protein N3 OS=Bos taurus OX=9913 GN=FOXN3 PE=4 SV=1 CANONICAL=A0A3Q1LX68-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LX68-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68/entry", "sequence": { "sequence": "MGPVMPPSKKPESSGISVSSGLSQCYRGSGFSKALQEDDDLDFPLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGDSVLRSVSPVQDPDDDPPPSPAHSDVPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPHSNVFNTPPASPQAYQSTSGPPLWPGSTFFKRNGALLQDPDIDAATAMMLLNTPPEIHAGFPPGVIQNGTRVLSRGLFPGVRPLPVTPIGMTAAVRNGLPGCRLRTESEPACGSPVVSGDPKEDHTYSSAKAAAARSASPASDCASSSSADEPDEVAAKGGPEGSEGSCPSRESHSEPEEDGRPRGPREAPGDGGPAHKKRPPAAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETAKN", "length": 480, "header": "tr|A0A3Q1LX68-1|A0A3Q1LX68_BOVIN Isoform 1 of Forkhead box protein N3 OS=Bos taurus OX=9913 GN=FOXN3 PE=4 SV=1 CANONICAL=A0A3Q1LX68-1" }, "locus": { "chromosome": "10", "start_pos": 101090098, "end_pos": 100837837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090351.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090351.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102764.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102764.1" } ] } }, { "isoform_ac": "G3MX01-1", "url": "https://www.uniprot.org/uniprotkb/G3MX01/entry", "sequence": { "sequence": "MGPVMPPSKKPESSGISVSSGLSQCYRGSGFSKALQEDDDLDFPLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGDSVLRSVSPVQDPDDDPPPSPAHSDVPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPHSNVFNTPPASPQAYQSTSGPPLWPGSTFFKRNGALLQVPPGVIQNGTRVLSRGLFPGVRPLPVTPIGMTAAVRNGLPGCRLRTESEPACGSPVVSGDPKEDHTYSSAKAAAARSASPASDCASSSSADEPDEVAAKGGPEGSEGSCPSRESHSEPEEDGRPRGPREAPGDGGPAHKKRPPAAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETAKN", "length": 458, "header": "tr|G3MX01-1|A0A3Q1LX68_BOVIN Computationally mapped isoform of Forkhead box protein N3 OS=Bos taurus OX=9913 GN=FOXN3 PE=4 SV=2 CANONICAL=A0A3Q1LX68-1" }, "locus": { "chromosome": "10", "start_pos": 101090098, "end_pos": 100837837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069802.1", "url": "https://www.ensembl.org/id/ENSBTAT00000069802.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061466.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061466.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505469", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505469", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JYT8-1", "protein_name": "Forkhead box protein N3", "gene_name": "Foxn3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGPVMPASKKPESSGISVSSGLSQRYRGSGFSKALQEDDDLDFPLPDIRLEEGTMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPPPTPQAYQSTSGPPIWPGSTFFKRNGALLQDPDIDAASAMMLLNSPPEIQAGFSPGVIQNGARVLSRGLFPGARPLPITPIGMTAAIRNSITSCRVRTESEPPCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADDHYEFATKGSQEGSEGSFQSHESHSEPEEDDRKPSQKEGKDALGDSGYASQHRKRQHLAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETAKN", "length": 479 }, "evidence": [ { "id": "A0A3Q1LX68", "url": "https://omabrowser.org/oma/group/A0A3Q1LX68/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8D0JTS1-1", "protein_name": "Forkhead box protein N3", "gene_name": "FOXN3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGPVMPPSKKPESSGISVSSGLSQCYRGSSFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGDSVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHSHSNVFNTPPASPQAYQSTSGPPIWPGSTFFKRNGALLQDPDIDAASAMMLLNTPPEIQAGFPPGVIQNGARVLSRGLFPGVRPLPITPIGMTAAVRNGLTSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSHARSTSPASDCVSSSSADDHYEFATKGSQEGSEGSFQSHESHSETEEDDRKCSPKEAKDALGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETTKN", "length": 485 }, "evidence": [ { "id": "A0A3Q1LX68", "url": "https://omabrowser.org/oma/group/A0A3Q1LX68/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M9PED3-1", "protein_name": "Forkhead box protein N3", "gene_name": "foxn3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGPVMPPSKKPESSGVSVASGLSQFYQASSITRALQEAEEMDLALPTIKLEKGSVEDEELTNLNWLHESKNLLNSFGDPVLRSVSPVQDLDDDTPPSPAHSDLPYDAKQNPNCKPPYSFSCLIFMAIEDAPSKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKDRSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPYSQVFTTPPTSPQAYQSMSSPPIWPGSPFYRKNKGVLLQVPQGVIQNGARMMSQGLFPGIRPLPINPIVSRTAAVRSVLGYRITSDTEPTQNSPLATSDPKEDHTYSFAKSSGSDAEEEAQCDGSELNFHTNETGSDAEDDDKSKIKKEPKEWSVDALALAQHKKRQLLTKVKQRVASDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGVRACLNNITNRTAKGQKEQK", "length": 441 }, "evidence": [ { "id": "A0A3Q1LX68", "url": "https://omabrowser.org/oma/group/A0A3Q1LX68/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A9J7G2R2-1", "protein_name": "Forkhead box protein N3", "gene_name": "Foxn3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGPVMPASKKPESSGISVSSGLSHCYPGSGFSKALQEDDDLDFPLPDIRLEEGTMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPPPTPQAYQSTSGPPIWPGSTFFKRNGALLQDPDIDAASAMMLLNSPPEIQAGFSPGVIQNGARVLSRGLFPGVRPLPITPIGMTAAIRNSISSCRMRTESEPPCGSPVVSGDPKEDHNYSSAKSSNARSTSPASDSISSSSSSSADDHYEFATKGSQEGSEGSFQSHESHSETEEDDRKPSQKEAKDALGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETTKN", "length": 480 }, "evidence": [ { "id": "A0A3Q1LX68", "url": "https://omabrowser.org/oma/group/A0A3Q1LX68/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O00409-1", "protein_name": "Forkhead box protein N3", "gene_name": "FOXN3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQDPDIDAASAMMLLNTPPEIQAGFPPGVIQNGARVLSRGLFPGVRPLPITPIGVTAAMRNGITSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADDHYEFATKGSQEGSEGSEGSFRSHESPSDTEEDDRKHSQKEPKDSLGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETTKN", "length": 490 }, "evidence": [ { "id": "A0A3Q1LX68", "url": "https://omabrowser.org/oma/group/A0A3Q1LX68/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q499D0-1", "protein_name": "Forkhead box protein N3", "gene_name": "Foxn3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGPVMPASKKAESSGISVSSGLSQRYRGSGFSKALQEDDDLDFPLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPPPTPQAYQSTSGPPIWPGSTFFKRNGALLQVSPGVIQNGARVLSRGLFPGVRPLPITPIGMTAAIRNSITSCRMRTESEPPCGSPVVSGDPKEDHNYSSAKSSTARSTSPTSDSISSSSSSADDHYEFATKGSQEGSEGSFQSHESHSEPEEEDRKPSPKEGKDALGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETAKN", "length": 457 }, "evidence": [ { "id": "A0A3Q1LX68", "url": "https://omabrowser.org/oma/group/A0A3Q1LX68/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68" } ], "pmid": "" }, { "name": "cis-regulatory region sequence-specific DNA binding", "id": "GO:0000987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000987", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68" } ], "pmid": "" }, { "name": "mitotic G2 DNA damage checkpoint signaling", "id": "GO:0007095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007095", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX68", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 462, "end_pos": 464, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LX68-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 480, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LX68-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LX68" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LX68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX68" }, { "id": "PRU00089", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00089" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "Fork-head", "eco_id": "ECO_0000256", "start_pos": 114, "end_pos": 201, "start_aa": "Lys", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 165, "end_pos": 167 }, { "start_pos": 278, "end_pos": 280 }, { "start_pos": 462, "end_pos": 464 }, { "start_pos": 465, "end_pos": 467 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LX83-1", "uniprot_ac": "A0A3Q1LX83", "uniprot_id": "A0A3Q1LX83_BOVIN", "mass": { "chemical_mass": 31579.0, "monoisotopic_mass": 31579.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Proteasome subunit alpha type", "type": "recommended", "evidence": [ { "id": "A0A3Q1LX83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX83/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX83", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX83#function" }, { "database": "UniProtKB", "id": "ARBA00003876", "url": "https://www.uniprot.org/uniprotkb/ARBA00003876#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX83", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX83" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX83", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000000242", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000242", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03750", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03750", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000426", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000426", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001353", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001353", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR11599", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11599", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00227", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00227", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10584", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10584", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LX83", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LX83-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX83-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANKHMKRCSTSLIIREMQIKTTMRYHFTPVRMAAIQKSTSSALGLRVKMAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSCGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA", "length": 283, "header": "tr|A0A3Q1LX83-1|A0A3Q1LX83_BOVIN Isoform 1 of Proteasome subunit alpha type OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0A3Q1LX83-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LX83-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX83/entry", "sequence": { "sequence": "MANKHMKRCSTSLIIREMQIKTTMRYHFTPVRMAAIQKSTSSALGLRVKMAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSCGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA", "length": 283, "header": "tr|A0A3Q1LX83-1|A0A3Q1LX83_BOVIN Isoform 1 of Proteasome subunit alpha type OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0A3Q1LX83-1" }, "locus": { "chromosome": "1", "start_pos": 57799468, "end_pos": 57798620, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000299.3", "url": "https://www.ensembl.org/id/ENSBTAT00000000299.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065351.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065351.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LX83", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX83" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": 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Also possesses antiviral activity by recognizing gammaherpesvirus transcripts in the context of lytic reactivation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0#function" }, { "database": "UniProtKB", "id": "ARBA00054358", "url": "https://www.uniprot.org/uniprotkb/ARBA00054358#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DDX49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0", "locus": { "chromosome": "7", "start_pos": 4284747, "end_pos": 4292511, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000811", "url": "https://www.ensembl.org/id/ENSBTAG00000000811" } ] } } ], "crossref": [ { "id": "A0A3Q1LXD0", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LXD0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000811", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000811", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17955", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17955", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18787", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18787", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXD0", "url": "https://www.orthodb.org/?gene=A0A3Q1LXD0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N0P2", "url": "https://www.orthodb.org/?gene=F1N0P2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47959", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47959", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47959:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47959:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXD0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0P2", "url": "https://www.uniprot.org/uniprotkb/F1N0P2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N0P2-1", "url": "https://www.uniprot.org/uniprotkb/F1N0P2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGFAELGLSSWLVEQCRQMGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFSIKKIRFLVPTPCLLRLMLQVMDEADRLLEQGCTDFTVDLEVILAAVPARRQTLLFSATLTDTLRELQGLATNQPFFWEAQAPVRTVEQLDQRYLLVPEKVKDAYLVHLIQNFQDEHEDWSIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLVHAIEEQIKKKLEEFPVEEAQVLQILTQVNVVRRECEIKLEAANFDEKKEINKRKQMILEGKDPDLEAKRKAELAKIKQKNRRFKEKVEQTLQRQKASRTDRRGRPPRARPEASLSLAPAQGPA", "length": 495, "header": "tr|A0A3Q1LXD0-1|A0A3Q1LXD0_BOVIN Isoform 1 of Probable ATP-dependent RNA helicase DDX49 OS=Bos taurus OX=9913 GN=DDX49 PE=3 SV=2 CANONICAL=A0A3Q1LXD0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXD0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0/entry", "sequence": { "sequence": "MAGFAELGLSSWLVEQCRQMGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMDMVAQALELSRKPHVVIATPGRLADHLRSSNTFSIKKIRFLVPTPCLLRLMLQVMDEADRLLEQGCTDFTVDLEVILAAVPARRQTLLFSATLTDTLRELQGLATNQPFFWEAQAPVRTVEQLDQRYLLVPEKVKDAYLVHLIQNFQDEHEDWSIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLVHAIEEQIKKKLEEFPVEEAQVLQILTQVNVVRRECEIKLEAANFDEKKEINKRKQMILEGKDPDLEAKRKAELAKIKQKNRRFKEKVEQTLQRQKASRTDRRGRPPRARPEASLSLAPAQGPA", "length": 495, "header": "tr|A0A3Q1LXD0-1|A0A3Q1LXD0_BOVIN Isoform 1 of Probable ATP-dependent RNA helicase DDX49 OS=Bos taurus OX=9913 GN=DDX49 PE=3 SV=2 CANONICAL=A0A3Q1LXD0-1" }, "locus": { "chromosome": "7", "start_pos": 4292355, "end_pos": 4285140, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074782.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074782.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060175.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060175.2" } ] } }, { "isoform_ac": "F1N0P2-1", "url": "https://www.uniprot.org/uniprotkb/F1N0P2/entry", "sequence": { "sequence": "MAGFAELGLSSWLVEQCRQMGLKQPTPVQLGCIPAILEGRDCLGCAKTGSGKTAAFVLPILQKLSEDPYGIFCLVLTPTRELAYQIAEQFRVLGKPLGLKDCIIVGGMATNQPFFWEAQAPVRTVEQLDQRYLLVPEKVKDAYLVHLIQNFQDEHEDWSIIIFTNTCKTCQILCMMLRKFNFPTVALHSMMKQKERFAALAKFKSSIYRILIATDVASRGLDIPTVQVVINHNTPGLPKIYIHRVGRTARAGRQGQAITLVTQYDIHLVHAIEEQIKKKLEEFPVEEAQVLQILTQVNVVRRECEIKLEAANFDEKKEINKRKQMILEGKDPDLEAKRKAELAKIKQKNRRFKEKVEQTLQRQKASRTDRRGRPPRARPEASLSLAPAQGPA", "length": 392, "header": "tr|F1N0P2-1|A0A3Q1LXD0_BOVIN Computationally mapped isoform of Probable ATP-dependent RNA helicase DDX49 OS=Bos taurus OX=9913 GN=DDX49 PE=3 SV=5 CANONICAL=A0A3Q1LXD0-1" }, "locus": { "chromosome": "7", "start_pos": 4292355, "end_pos": 4285140, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056136.5", "url": "https://www.ensembl.org/id/ENSBTAT00000056136.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047676.5", "url": "https://www.ensembl.org/id/ENSBTAP00000047676.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of cell growth", "id": "GO:0030307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030307", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ], "pmid": "" }, { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ], "pmid": "" }, { "name": "regulation of rRNA stability", "id": "GO:0044357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044357", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXD0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "R-BTA-6791221", "name": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MY97-1", "Q29S22-1", "A5D7C1-1", "A0A3Q1LXD0-1" ], "evidence": [ { "id": "R-BTA-6791221", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791221" } ] }, { "id": "R-BTA-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29S22-1", "A5D7C1-1", "A0A3Q1LXD0-1" ], "evidence": [ { "id": "R-BTA-6791222", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791222" } ] }, { "id": "R-BTA-6791227", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29S22-1", "F1MKX7-1", "A5D7C1-1", "A0A3Q1LXD0-1" ], "evidence": [ { "id": "R-BTA-6791227", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791227" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LG16" } ] } ] }, { "uniprot_ac": "A0A3Q1LQC3", "gene_name": "HELQ", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0A3Q1LQC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQC3" } ] } ] }, { "uniprot_ac": "A0A3Q1LQN7", "gene_name": "DDX17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LQN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQN7" } ] } ] }, { "uniprot_ac": "A0A3Q1LSH0", "gene_name": "MOV10L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor 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"id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": 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"gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by 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"uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", 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"UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MKX7", "gene_name": "XRN2", "activity": [ { "ec_number": "3.1.13.-", "activity": "", "evidence": [ { "id": "F1MKX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKX7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MY97", "gene_name": "FTSJ3", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "F1MY97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY97" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", 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"https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": 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+ phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", 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protein 3 OS=Bos taurus OX=9913 GN=TMED3 PE=3 SV=2 CANONICAL=A0A3Q1LXI8-1" }, "locus": { "chromosome": "21", "start_pos": 25535347, "end_pos": 25517919, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083758.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083758.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061921.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061921.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" }, { "id": "R-BTA-6811434", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811434", "resource": "Reactome", "description": "COPI-dependent Golgi-to-ER retrograde traffic" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXI8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXI8" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXI8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXI8" } ], "pmid": "" }, { "name": "COPII-coated ER to Golgi transport vesicle", "id": "GO:0030134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030134", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXI8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXI8" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXI8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXI8" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment membrane", "id": "GO:0033116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033116", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXI8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXI8" } ], "pmid": "" }, { "name": "endoplasmic reticulum-Golgi intermediate compartment", "id": "GO:0005793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005793", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXI8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXI8" } ], "pmid": "" }, { "name": "COPI vesicle coat", "id": "GO:0030126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030126", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXI8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXI8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXI8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXI8" } ], "pmid": "" }, { "name": "endoplasmic reticulum to Golgi vesicle-mediated transport", "id": "GO:0006888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006888", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXI8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXI8" } ], "pmid": "" }, { "name": "Golgi organization", "id": "GO:0007030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXI8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXI8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LXI8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 218, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LXI8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LXI8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXI8" }, { "id": "PS50866", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50866" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GOLD", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 121, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": 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"count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LXK3-1", "uniprot_ac": "A0A3Q1LXK3", "uniprot_id": "A0A3Q1LXK3_BOVIN", "mass": { "chemical_mass": 138084.0, "monoisotopic_mass": 138084.0 }, "refseq": {}, "gene_names": [ { "name": "TTC17", "type": "recommended", "evidence": [ { "id": "A0A3Q1LXK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXK3" } ] } ], "protein_names": [ { "name": "Tetratricopeptide repeat domain 17", "type": "synonym", "evidence": [ { "id": "A0A3Q1LXK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXK3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in primary ciliogenesis by modulating actin polymerization.", "evidence": [ { "database": "UniProtKB", "id": "E1B8P6", "url": "https://www.uniprot.org/uniprotkb/E1B8P6#function" }, { "database": "UniProtKB", "id": "ARBA00037538", "url": "https://www.uniprot.org/uniprotkb/ARBA00037538#function" }, { "database": "UniProtKB", "id": "E1BLC6", "url": "https://www.uniprot.org/uniprotkb/E1BLC6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXK3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXK3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTC17", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXK3", "locus": { "chromosome": "15", "start_pos": 73588096, "end_pos": 73460894, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031299", "url": "https://www.ensembl.org/id/ENSBTAG00000031299" } ] } } ], "crossref": [ { "id": "A0A3Q1LXK3", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LXK3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031299", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031299", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PDDHAKQ", "url": "https://omabrowser.org/oma/group/PDDHAKQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXK3", "url": "https://www.orthodb.org/?gene=A0A3Q1LXK3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B8P6", "url": "https://www.orthodb.org/?gene=E1B8P6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BLC6", "url": "https://www.orthodb.org/?gene=E1BLC6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16091", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16091", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16091:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16091:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LXK3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXK3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVQ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8P6", "url": "https://www.uniprot.org/uniprotkb/E1B8P6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8P6-1", "url": "https://www.uniprot.org/uniprotkb/E1B8P6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLC6", "url": "https://www.uniprot.org/uniprotkb/E1BLC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLC6-1", "url": "https://www.uniprot.org/uniprotkb/E1BLC6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANRRGSLPLPVRVAGPGGGKMAVAVGVRGRCELPPCSSPGWFLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQETTVNYLKELEKQLVAQKIHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDISPEDYIDTESPVPPDPEQPDCTKILELPYSIHAFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHEGLQKNSSSWVLYNMASFYWRIKNEPYQVVECAMRALHFSSRHNKDIALVNLANVLHRAHFSADAAVVVHAALDDSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLVNQQHSLHCQWDQPVRYHRGDIFENVDYVQFGEDSSTSSMMSVNFDVQANQSDISDLVKSSPVAHSVLWIWGRDSDAYRDKQHILWPKRADCAESYPRVPIGGELPTYFLPPENKGLRIHELNSDDYSSEEEAQTPDCSITDIRKSQTLSYLVKELEVRMDLKAKMPDDHARKILLSRINNYTIPEEEIGSFLFHAINKPNAPVWLILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQDVPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGNCHAKTLDNSHDKQKYFDKSQSLDAAEEEPSEAGTEEDPVLSVQDSGRDSDVLRLESTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGIARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTSGKKVESSQTEDVHRNRASLEITGPKVASPGPQGKKRDYQSLGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPVCNGNLPTSMHTLDHLQGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKRTARLCDSEPQCGLWTEAGHQLLLTSCSVTWSWHHDGKQLPHSAGRAPHQPGQHPAQRQALERRRHRGHHGGGDRAALRRQPLHAGQRIRGDGRV", "length": 1223, "header": "tr|A0A3Q1LXK3-1|A0A3Q1LXK3_BOVIN Isoform 1 of Tetratricopeptide repeat domain 17 OS=Bos taurus OX=9913 GN=TTC17 PE=4 SV=2 CANONICAL=A0A3Q1LXK3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXK3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXK3/entry", "sequence": { "sequence": 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"length": 1223, "header": "tr|A0A3Q1LXK3-1|A0A3Q1LXK3_BOVIN Isoform 1 of Tetratricopeptide repeat domain 17 OS=Bos taurus OX=9913 GN=TTC17 PE=4 SV=2 CANONICAL=A0A3Q1LXK3-1" }, "locus": { "chromosome": "15", "start_pos": 73586956, "end_pos": 73461093, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070079.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070079.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061936.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061936.2" } ] } }, { "isoform_ac": "A0AAA9SVQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVQ7/entry", "sequence": { "sequence": "MAVAVGVRGRCELPPCSSPGWFLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQETTVNYLKELEKQLVAQKIHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDISPEDYIDTESPVPPDPEQPDCTKILELPYSIHAFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHEGLQKNSSSWVLYNMASFYWRIKNEPYQVVECAMRALHFSSRHNKDIALVNLANVLHRAHFSADAAVVVHAALDDSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLVNQQHSLHCQWDQPVRYHRGDIFENVDYVQFGEDSSTSSMMSVNFDVQANQSDISDLVKSSPVAHSVLWIWGRDSDAYRDKQHILWPKRADCAESYPRVPIGGELPTYFLPPENKGLRIHELNSDDYSSEEEAQTPDCSITDIRKSQTLSYLVKELEVRMDLKAKMPDDHARKILLSRINNYTIPEEEIGSFLFHAINKPNAPVWLILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQDVPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGNCHAKTLDNSHDKQKYFDKSQSLDAAEEEPSEAGTEEDPVLSVQDSGRDSDVLRLESTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGIARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTSGKKVESSQTEDVHRNRASLEITGPKVASPGPQGKKRDYQSLGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPVCNGNLPTSMHTLDHLQGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKTRIEWLKTKLLFAQDPTT", "length": 1085, "header": "tr|A0AAA9SVQ7-1|A0A3Q1LXK3_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 17 OS=Bos taurus OX=9913 GN=TTC17 PE=4 SV=1 CANONICAL=A0A3Q1LXK3-1" }, "locus": { "chromosome": "15", "start_pos": 73560918, "end_pos": 73461156, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094594.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094594.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087263.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087263.1" } ] } }, { "isoform_ac": "E1B8P6-1", "url": "https://www.uniprot.org/uniprotkb/E1B8P6/entry", "sequence": { "sequence": "MANRRGSLPLPVRVAGPGGGKMAVAVGVRGRCELPPCSSPGWFLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQETTVNYLKELEKQLVAQKIHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDISPEDYIDTESPVPPDPEQPDCTKILELPYSIHAFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHEGLQKNSSSWVLYNMASFYWRIKNEPYQVVECAMRALHFSSRHNKDIALVNLANVLHRAHFSADAAVVVHAALDDSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLVNQQHSLHCQWDQPVRYHRGDIFENVDYVQFGEDSSTSSMMSVNFDVQANQSDISDLVKSSPVAHSVLWIWGRDSDAYRDKQHILWPKRADCAESYPRVPIGGELPTYFLPPENKGLRIHELNSDDYSSEEEAQTPDCSITDIRKSQTLSYLVKELEVRMDLKAKMPDDHARKILLSRINNYTIPEEEIGSFLFHAINKPNAPVWLILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQDVPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGIARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTSGKKVESSQTEDVHRNRASLEITGPKVASPGPQGKKRDYQSLGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPVCNGNLPTSMHTLDHLQGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRSP", "length": 1162, "header": "tr|E1B8P6-1|A0A3Q1LXK3_BOVIN Computationally mapped isoform of Tetratricopeptide repeat domain 17 OS=Bos taurus OX=9913 GN=TTC17 PE=4 SV=3 CANONICAL=A0A3Q1LXK3-1" }, "locus": { "chromosome": "15", "start_pos": 73587077, "end_pos": 73461093, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019253.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019253.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019253.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019253.6" } ] } }, { "isoform_ac": "E1BLC6-1", "url": "https://www.uniprot.org/uniprotkb/E1BLC6/entry", "sequence": { "sequence": "MANRRGSLPLPVRVAGPGGGKMAVAVGVRGRCELPPCSSPGWFLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQETTVNYLKELEKQLVAQKIHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDISPEDYIDTESPVPPDPEQPDCTKILELPYSIHAFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHEGLQKNSSSWVLYNMASFYWRIKNEPYQVVECAMRALHFSSRHNKDIALVNLANVLHRAHFSADAAVVVHAALDDSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLVNQQHSLHCQWDQPVRYHRGDIFENVDYVQFGEDSSTSSMMSVNFDVQANQSDISDLVKSSPVAHSVLWIWGRDSDAYRDKQHILWPKRADCAESYPRVPIGGELPTYFLPPENKGLRIHELNSDDYSSEEEAQTPDCSITDIRKSQTLSYLVKELEVRMDLKAKMPDDHARKILLSRINNYTIPEEEIGSFLFHAINKPNAPVWLILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQDVPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGNCHAKTLDNSHDKQKYFDKSQSLDAAEEEPSEAGTEEDPVLSVQDSGRDSDVLRLESTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGIARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTSGKKVESSQTEDVHRNRASLEITGPKVASPGPQGKKRDYQSLGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPVCNGNLPTSMHTLDHLQGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRSP", "length": 1219, "header": "tr|E1BLC6-1|E1BLC6_BOVIN Computationally mapped isoform of Tetratricopeptide repeat protein 17 OS=Bos taurus OX=9913 GN=TTC17 PE=3 SV=3 CANONICAL=A0A3Q1LXK3-1" }, "locus": { "chromosome": "15", "start_pos": 73587077, "end_pos": 73461093, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061051.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061051.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053799.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053799.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287A717-1", "protein_name": "Tetratricopeptide repeat protein 17", "gene_name": "TTC17", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAAVGVRGRCELPPCSSPGWFLSLSALLSVATRGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQETTVNYLKELEKQLVAQKIHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDISPEDYIDTESPVPPDPEQPDCTKILELPYSIHAFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHEGLQKNSSSWVLYNMASFYWRIKNEPYQVVECAMRALHFSSRHNKDIALVNLANVLHRAHFSADAAVVVHAALDDSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLVNQQHSLHCQWDQPVRYHRGDIFENVDYVQFGEDSSTSSMMSVNFDVQANQSDISDLVKSSPVAHSILWIWGRDSDAYRDKQHILWPKRADCAESYPRVPVGGELPTYFLPPENKGLRIHELNSDDYSSEEEAQTPDCSITDFRKSQTLSYLVKELEVRMDLKAKMPDDHARKILLSRINNYTIPEEEIGSFLFHAINKPNAPVWLILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQDVPLVNLANLLIHYGLHLDATKLLLQALAVNSSEPLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENNLKLIRCMQFYPFLYNITSSVCSGTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGVAKSSCYGDCRSEDDEATEWITFQVKRVKKPKGEHKKTPGKKVESNQVENVHRNQANLEITGPKVASPGPQGKKRDYQSLGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLQGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRSP", "length": 1141 }, "evidence": [ { "id": "A0A3Q1LXK3", "url": "https://omabrowser.org/oma/group/A0A3Q1LXK3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZHB1-1", "protein_name": "Tetratricopeptide repeat protein 17", "gene_name": "TTC17", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKERRAASGRALAERGTRGGGLRPRPVRSPPPKMAERVFPVPGGAGRPGLGKMAAAAASGWGGLGRAWVFSGWALGLCSLLASGTRPAAATTHWVVTEDGKIQQQVDSPMNLRNPHDLVILMRQETTVNYLKELEKQLVAQKIHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDIRPEDYIDTKSPVPPDLQQPDCTKVLDLPYSIHAFQHLRGVQERVNLSAPLLPKEDPIFTYLSRRLGRSIEEIGHRIYDGLMKNSSSWVLYNMASFYWRIKNEPYQVVECAMRALHFSSRQNKDIALVNLANILHRAHFSADAAIVVHAALDYSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQAKPGFEQAVKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQDVLDKYKLIQEEQILRNIIHETQMAKEAQLGNHQICRLSNQQHSLHCQWDQPVRYHRGDIFENVEYVQFGEDSSTSSMTSLNFDLHANQSGHSQSLQSSPVARSIVSVWSVESNRDKQHLLWPQRSECMKSFPKIPDPEELPTYFLPPENRGFRIQSILNIPREAVGHEDTQVPDCSSITDARNNESLYLLVRELDGNLDLKMKMPDDQARQILHSRINNQAITQEKMEAFLDHAMKKPQDPLWLVLNEAGLYWRAVGNSTFAITCLQKAFNLAPHEYQDIPLVNLANLLIHYGLHLDASRLLLQALAINASEPLTFLSLGNAYLALNNISGALQAFRHALDLTTKCLECESSLKMIRCLQFYPFLYNITSSVCSGHCHEKSSEGSHDKEKYFDDHHESVTGMAEGHSEGGTEDTEILTQRSVRDPSILKLENTVTAESNGSEGMESLEDDQMSEEMLALVDEFENSWPQEAFEGALEVKGRRMDLQGIRVLKKGAQDGLASSCFGDCGDDDEAEWITFQVKRLKKPKADSLDLQEPTGRNGEEGTNGENENFYQTALEISGPKIPSPGPIGKRHDYRSLGWPSPDECLKLRRVELTTVASTWLAVSAKNIDITEHIDFATQLQEPAMEPLCNPNLPASMHTLDHLQGVSSRASLHYTGESQLKEVLQNLGKDQYSPQSLEQVGTRIAKALEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHHMKDVPLISLANIFHNARLWNDAIIVATMAVEIAPHFVVNHFTLANVYVAMEEFEKAMKWYESTLKLQPEFAPAKNRIHTIQCHLLMKKERRSP", "length": 1252 }, "evidence": [ { "id": "A0A3Q1LXK3", "url": "https://omabrowser.org/oma/group/A0A3Q1LXK3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B5DEL3-1", "protein_name": "Tetratricopeptide repeat protein 17", "gene_name": "Ttc17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAIGVRGRFELLSCSGPGWLISLSALLSVVARGALATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQETTVNYLKELEKQLVAQKIHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDVRPEDFIDTESPVPPDPEQPDCTKILELPYSIHAFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHEGLQKNSSSWVLYNLASFYWRIKNEPYQVVECTMRALHFSSRHNKDIALVNLANVLHRAHFSADAAVVVHAALDDSAFFTSYYTLGNIYAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLVNQQHSLHCQWDQPVRYHRGDIFENVDYVQFGDDSSTSSMMSVNFDVPTNQSDVSESVRSSPVAHSVLWVWGRDSDAYRDKQHILWPKRADCTDSYPRVPLGGELPTYFLPPENKGLRIHELTSDDYSSEEEAQTPDCSITDFRKSHTLSYLVKELEVRMDLKAKIPDDHARKILLSRIKNYTIPEEEIGSFLFHAINKPNAPVWLILNEAGLYWRAVGNSTFAIACLQRALNLAPVQYQDIPLVNLANLLIHYGLHLDATKLLLQALAVNSSEPLTFLSLGNAYLALKNVSGALEAFRQALKLTTRCPECESSLKLIRCMQFYPFLYNITSSVCSGHCHEKTLDNSHDKQKYFAKPQSLDAAEEEPSRHGADEDPVLSVENAGRDSDALRLESTVVEESNGSDEVEKSEETKMSEEILALVDEFQQAWPLEGLGGTLEMKGRRLDLQGIRVLKKGPQDGVAKSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKPPGKKVEASQAENGQRYQANLEITGPKVASPGPQEKKRDYQSMGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLHGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWNDAVVVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRSP", "length": 1198 }, "evidence": [ { "id": "A0A3Q1LXK3", "url": "https://omabrowser.org/oma/group/A0A3Q1LXK3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7F211-1", "protein_name": "Tetratricopeptide repeat protein 17", "gene_name": "ttc17", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTRSFRVEWTDGRKMADDKSNSIGDNSTNKRLWSSSIRGSALIFICALLAEPARATTHWVVTEDGKIQQQVDSPLNLKHPHHLVLFMQQETRVNYLKKLEKQLVAQKIHIEENEDRDTGLEQRHYKEDADCVTAKVPLGDLDLYDGTFISLESKDINPEQFLDLMSALPPDLEKPDCAKLLDLPYSIHAFQHLRGVQEKVNLTSPLLSKDDPIFTSLCLKLGQSVDEVGHRIHQALLKNSSSWVLYNLASFYWRIKNEPRRAVDCVVRALHFSPRQHKDVALVNMANVLHRAHFSADAAILAHAALDLTTDLLTSHYTLGNIYAMLGEYNHSVLCYEQALQAQPGFEQALRRKHAVLCQQKLEQRLEAQHRSLQRTLNELKEYQKQHDHYLRQQEMLDKHKLIQEEQILRNIIHETQMAKEAQLGNHQMCHMGQQKFTLHCPFDLPVRYHRGELFENVHYIQFGEEVSVASSVALVSELSVNESHSPQQSYTVSLGREPAAHWDKETTTTDESRTVLWPRRSDCAQRFPTIPPAYLLPTYYLPPESRNLKALNILLESISPPPSAKMPDCSLKNVVGNRDPLESMSWALEKELRDPQAAEVLLKRSGGRSLEQTGALIAQALEKMSGPRWMMQNEAGLFWRAKGNGTQALVCLRQALHSAPPQHRDLPLVNTANLLLHYGLHSEAHELLQQALQINQSEPHTLLSLVNVHLSQGNLTGALAVFRQALSLSVHCGQCRASLPLMRCLQFYPFLYNLQHQACSSGGACEVEEDSELEDWDTGSSSSGRQEVWDSDAMPVSALEDSLLFEKVVVDSNGSGEASGQDRTREPKAEGGEEEEQDWRLREELIGAFEGALDMNGKTGDLRGIRVLKNDRVMGARGGGPCFGNCEDDEGAEWITFQVKRVKKPKSDASEGWVGEGDVRQTEPTASNSILEISGPTIPSPGPSERWKDYSSLGWPGPEECQRTRRVDLTTVASTWLAVSAKNIDITEHIDFATPLQEPAVEPVCNANLPASMHTLDHLSGVANRGGIHYTGESQLREVLQNLGKDKFPSQSFEQVGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKRAIDCLRQALNYAPHHMKDVPLISLANIFQNARLWEDALTVARMAVEIAPHFVVNHFTLANVYIAMEEFEKAMHWYESTLKLQPEFGPAKDRLRTIQCYLLSKRDRRAP", "length": 1198 }, "evidence": [ { "id": "A0A3Q1LXK3", "url": "https://omabrowser.org/oma/group/A0A3Q1LXK3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E9PVB5-1", "protein_name": "Tetratricopeptide repeat protein 17", "gene_name": "Ttc17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAIGVRGRFELLPRSGPGWLLSLSALLSVVARGALATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQETTVNYLKELEKQLVAQKIHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDIRPEDFIDTESPVPPDPEQPDCTKILELPYSIHAFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHEGLQKNASSWVLYNLASFYWRIKNEPYQVVECAMRALHFSSRHNKDIALVNLANVLHRAHFSADAAVVVHAALDDSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQAKPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLVNQQHSLHCQWDQPVRYHRGDIFENVDYVQFGDDSSTSSMMSVNFDVPTNQSDVSESVRSSPVAHSVLWVWGRDSDAYRDKQHILWPKRADCTDSYPRVPLGGELPTYFLPPENKGLRIHELTSDDYSSEEEAQPPDCSITDYRKSHTLSYLVKELEVRMDLKAKIPDDHARKILLSRIKNYTVPEEEIGSFLFHAINKPNAPVWLILNEAGLYWRAVGNSTFAIACLQRALNLAPVQYQDIPLVNLANLLIHYGLHLDATKLLLQAVAVNSSEPLTFLSLGNAYLALKNVSGALEAFRQALKLSTKCPECESSLKLIRCMQFYPFLYNATSSVCGGHCHEKPLDNSHDKQKYFAKPQSLDAAAEEPSGHGADEDPVLSVENAGRDSDALRLESTVVEESNGSDEVEKSDETKMSEEILALVDEFQQAWPLEGFGGTLEMKGRRLDLQGIRVLKKGPQDGVAKSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKPPGKKVEASQAENGQRYQANLEITGPKVASPGPQEKKRDYQSLGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLHGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRSP", "length": 1198 }, "evidence": [ { "id": "A0A3Q1LXK3", "url": "https://omabrowser.org/oma/group/A0A3Q1LXK3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96AE7-1", "protein_name": "Tetratricopeptide repeat protein 17", "gene_name": "TTC17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAVGVRGRYELPPCSGPGWLLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNLKHPHDLVILMRQEATVNYLKELEKQLVAQKIHIEENEDRDTGLEQRHNKEDPDCIKAKVPLGDLDLYDGTYITLESKDISPEDYIDTESPVPPDPEQPDCTKILELPYSIHAFQHLRGVQERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHEGLQKNTSSWVLYNMASFYWRIKNEPYQVVECAMRALHFSSRHNKDIALVNLANVLHRAHFSADAAVVVHAALDDSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLVNQQHSLHCQWDQPVRYHRGDIFENVDYVQFGEDSSTSSMMSVNFDVQSNQSDINDSVKSSPVAHSILWIWGRDSDAYRDKQHILWPKRADCTESYPRVPVGGELPTYFLPPENKGLRIHELSSDDYSTEEEAQTPDCSITDFRKSHTLSYLVKELEVRMDLKAKMPDDHARKILLSRINNYTIPEEEIGSFLFHAINKPNAPIWLILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQDVPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQFYPFLYNITSSVCSGTVVEESNGSDEMENSDETKMSEEILALVDEFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGVARSSCYGDCRSEDDEATEWITFQVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVASPGPQGKKRDYQRLGWPSPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTLDHLHGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSMAALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRSP", 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"MDGRAWWATVHGVAKSWTRLNDFTSLLHFKIVPDASVWTLLSDCLNFRPPQVESEKANDWVSPGSRFGKTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLRREGADSNPKTSKLPTRPASTGVAGASGSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPALTSPGAALPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEAEVLRERVEELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAERTIDELKEQVDAALGAEEMVETLTDRNLDLEEKVRKLKETVGDLEAINEMNDELQENARETELELREQLDMAGAQVRDAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRALTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSESCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEASDIALLLRDLETSCSDTRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGTPSSNPYECLRQSCSLLISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQTLLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGGGAPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSTLKGAQMKASLAALPPLHVAKLSLPPHEGPGSKLAAGALYRKTNQLLETLNQLSACTHVVDITRSNPAAKSPSAQLLEQVAQLKSLSDTIEKLKDEVLKETVSQRPEATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLGQRHRLVLTQEQLHQLHDRLIS", "length": 1314, "header": "tr|A0A3Q1LJA4-1|A0A3Q1LJA4_BOVIN Computationally mapped isoform of Dynactin subunit 1 OS=Bos taurus OX=9913 GN=DCTN1 PE=1 SV=2 CANONICAL=A0A3Q1LQT4-1" }, "locus": { "chromosome": "11", "start_pos": 10268097, "end_pos": 10242121, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070221.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070221.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059425.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059425.2" } ] } }, { "isoform_ac": "A0A3Q1LQT4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4/entry", "sequence": { "sequence": "MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLRREGADSNPKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASGSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPALTSPGAALPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEAEVLRERVEELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAERTIDELKEQVDAALGAEEMVETLTDRNLDLEEKVRKLKETVGDLEAINEMNDELQENARETELELREQLDMAGAQVRDAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRALTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSESCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEASDIALLLRDLETSCSDTRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGTPSSNPYECLRQSCSLLISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQTLLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGGAPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSTLKGAQMKASLAALPPLHVAKLSLPPHEGPGSKLAAGALYRKTNQLLETLNQLSACTHVVDITRSNPAAKSPSAQLLEQVAQLKSLSDTIEKLKDEVLKETVSQRPEATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLGQRHRLVLTQEQLHQLHDRLIS", "length": 1281, "header": "tr|A0A3Q1LQT4-1|A0A3Q1LQT4_BOVIN Isoform 1 of Dynactin subunit 1 OS=Bos taurus OX=9913 GN=DCTN1 PE=1 SV=3 CANONICAL=A0A3Q1LQT4-1" }, "locus": { "chromosome": "11", "start_pos": 10268097, "end_pos": 10249548, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072514.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072514.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057372.3", "url": "https://www.ensembl.org/id/ENSBTAP00000057372.3" } ] } }, { "isoform_ac": "A0A3Q1M3Y3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3Y3/entry", "sequence": { "sequence": "MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLRREGADSNPKTSKLTTTRRPKPTRPASTGVAGASGSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPALTSPGAALPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEAEVLRERVEELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAERTIDELKEQVDAALGAEEMVETLTDRNLDLEEKVRKLKETVGDLEAINEMNDELQENARETELELREQLDMAGAQVRDAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRALTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSESCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEASDIALLLRDLETSCSDTRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGTPSSNPYECLRQSCSLLISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQTLLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGGGAPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSTLKGAQMKASLAALPPLHVAKLSLPPHEGPGSKLAAGALYRKTNQLLETLNQLSACTHVVDITRSNPAAKSPSAQLLEQVAQLKSLSDTIEKLKDEVLKETVSQRPEATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLGQRHRLVLTQEQLHQLHDRLIS", "length": 1263, "header": "tr|A0A3Q1M3Y3-1|A0A3Q1M3Y3_BOVIN Computationally mapped isoform of Dynactin subunit 1 OS=Bos taurus OX=9913 GN=DCTN1 PE=1 SV=1 CANONICAL=A0A3Q1LQT4-1" }, "locus": { "chromosome": "11", "start_pos": 10268097, "end_pos": 10249548, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070160.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070160.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064894.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064894.1" } ] } }, { "isoform_ac": "A0ABI0NPS1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NPS1/entry", "sequence": { "sequence": "MDGRAWWATVHGVAKSWTRLNDFTSLLHFKIVPDASVWTLLSDCLNFRPPQVESEKANDWVSPGSRFGKTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLRREGADSNPKTSKLEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEAEVLRERVEELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAERTIDELKEQVDAALGAEEMVETLTDRNLDLEEKVRKLKETVGDLEAINEMNDELQENARETELELREQLDMAGAQVRDAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRALTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSESCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEASDIALLLRDLETSCSDTRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGTPSSNPYECLRQSCSLLISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQTLLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGGGAPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSTLKGAQMKASLAALPPLHVAKLSLPPHEGPGSKLAAGALYRKTNQLLETLNQLSACTHVVDITRSNPAAKSPSAQLLEQVAQLKSLSDTIEKLKDEVLKETVSQRPEATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLGQRHRLVLTQEQLHQLHDRLIS", "length": 1250, "header": "tr|A0ABI0NPS1-1|A0ABI0NPS1_BOVIN Computationally mapped isoform of Dynactin subunit 1 OS=Bos taurus OX=9913 GN=DCTN1 PE=1 SV=1 CANONICAL=A0A3Q1LQT4-1" }, "locus": { "chromosome": "11", "start_pos": 10268097, "end_pos": 10242121, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145792.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145792.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104005.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104005.1" } ] } }, { "isoform_ac": "A0ABI0NSG1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSG1/entry", "sequence": { "sequence": "MMRQAPTARKTTTRRPKPTRPASTGVAGASGSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPALTSPGAALPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEAEVLRERVEELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAERTIDELKEQVDAALGAEEMVETLTDRNLDLEEKVRKLKETVGDLNEMNDELQENARETELELREQLDMAGAQVRDAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRALTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSESCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEASDIALLLRDLETSCSDTRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGTPSSNPYECLRQSCSLLISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQTLLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGGAPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSTLKGAQMKASLAALPPLHVAKLSLPPHEGPGSKLAAGALYRKTNQLLETLNQLSACTHVVDITRSNPAAKSPSAQLLEQVAQLKSLSDTIEKLKDEVLKETVSQRPEATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLGQRHRLVLTQEQLHQLHDRLIS", "length": 1144, "header": "tr|A0ABI0NSG1-1|A0ABI0NSG1_BOVIN Computationally mapped isoform of Dynactin subunit 1 OS=Bos taurus OX=9913 GN=DCTN1 PE=1 SV=1 CANONICAL=A0A3Q1LQT4-1" }, "locus": { "chromosome": "11", "start_pos": 10268097, "end_pos": 10255086, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141851.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141851.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106960.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106960.1" } ] } }, { "isoform_ac": "F1MIC9-1", "url": "https://www.uniprot.org/uniprotkb/F1MIC9/entry", "sequence": { "sequence": "MSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLRREGADSNPKTSKLTTTRRPKPTRPASTGVAGASGSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPALTSPGAALPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEAEVLRERVEELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAERTIDELKEQVDAALGAEEMVETLTDRNLDLEEKVRKLKETVGDLEAINEMNDELQENARETELELREQLDMAGAQVRDAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRALTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSESCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEASDIALLLRDLETSCSDTRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGTPSSNPYECLRQSCSLLISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQTLLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGGGAPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSTLKGAQMKASLAALPPLHVAKLSLPPHEGPGSKLAAGALYRKTNQLLETLNQLSACTHVVDITRSNPAAKSPSAQLLEQVAQLKSLSDTIEKLKDEVLKETVSQRPEATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLGQRHRLVLTQEQLHQLHDRLIS", "length": 1246, "header": "tr|F1MIC9-1|F1MIC9_BOVIN Computationally mapped isoform of Dynactin subunit 1 OS=Bos taurus OX=9913 GN=DCTN1 PE=1 SV=3 CANONICAL=A0A3Q1LQT4-1" }, "locus": { "chromosome": "11", "start_pos": 10268097, "end_pos": 10251230, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006430.8", "url": "https://www.ensembl.org/id/ENSBTAT00000006430.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006430.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006430.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 185, "start_aa": "Thr", "end_pos": 185, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr185", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 198, "start_aa": "Thr", "end_pos": 198, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr198", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-2132295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "resource": "Reactome", "description": "MHC class II antigen presentation" }, { "id": "R-BTA-2565942", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "resource": "Reactome", "description": "Regulation of PLK1 Activity at G2/M Transition" }, { "id": "R-BTA-3371497", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3371497", "resource": "Reactome", "description": "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" }, { "id": "R-BTA-380259", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "resource": "Reactome", "description": "Loss of Nlp from mitotic centrosomes" }, { "id": "R-BTA-380270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "resource": "Reactome", "description": "Recruitment of mitotic centrosome proteins and complexes" }, { "id": "R-BTA-380284", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "resource": "Reactome", "description": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "id": "R-BTA-380320", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "resource": "Reactome", "description": "Recruitment of NuMA to mitotic centrosomes" }, { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" }, { "id": "R-BTA-6811436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811436", "resource": "Reactome", "description": "COPI-independent Golgi-to-ER retrograde traffic" }, { "id": "R-BTA-8854518", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "resource": "Reactome", "description": "AURKA Activation by TPX2" } ], "orthologs": [ { "uniprot_canonical_ac": "O08788-1", "protein_name": "Dynactin subunit 1", "gene_name": "Dctn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQSRRHMSSRTPSGSRMSTEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGADAAAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGPSSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRSEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDSTMQLADHIKFTQSALDCMGVEVGRLRAFLQGGQEATDIALLLRDLETSCSDTRQFCKKIRRRMPGTDAPGIPAALAFGSQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGSPSSSPYECLRQSCTILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLDETQTLLRKKEKDFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEPQRGGAPGQAPGALPGPGLVKDSPLLLQQISAMRLHISQLQHENSILRGAQMKASLAALPPLHVAKLSLPPHEGPGGNLVAGALYRKTSQLLEKLNQLSTHTHVVDITRSSPAAKSPSAQLMEQVAQLKSLSDTIEKLKDEVLKETVTQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLGQRHRLVLTQEQLHQLHSRLIS", "length": 1281 }, "evidence": [ { "id": "A0A3Q1LQT4", "url": "https://omabrowser.org/oma/group/A0A3Q1LQT4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P13496-1", "protein_name": "Dynactin subunit 1", "gene_name": "DCTN1-p150", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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"length": 1265 }, "evidence": [ { "id": "A0A3Q1LQT4", "url": "https://omabrowser.org/oma/group/A0A3Q1LQT4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P28023-1", "protein_name": "Dynactin subunit 1", "gene_name": "Dctn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQSKRHMYNRTPSGSRMSTEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKILKREGADAAAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGPSSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRDQVRDLEEKLETLRLKRSEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEAKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFDLSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEESTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGSQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLPVAALEELAFKASEQIYGSPSSSPYECLRQSCSILISTMNKLATAMQEGEYDAERPPSKPPPVEPWPAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQTLLRKKEKEFEETMDALQADIDQLEAEKTELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGGTPGQAPGALPGPGPVKDSPLLLQQISAMRLHISQLQHENSILRGAQMKASLAALPPLHVAKFSLPPHEGPGGNLLSGALYRKTSQLLEKLNQLSTYTHVVDITRSSPACKSPSAQLMEQVAQLKSLSDTIEKLKDEVLKETVTQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGLGQRHRLVLTQEQLHQLHGRLIS", "length": 1280 }, "evidence": [ { "id": "A0A3Q1LQT4", "url": "https://omabrowser.org/oma/group/A0A3Q1LQT4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14203-1", "protein_name": "Dynactin subunit 1", "gene_name": "DCTN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS", "length": 1278 }, "evidence": [ { "id": "A0A3Q1LQT4", "url": "https://omabrowser.org/oma/group/A0A3Q1LQT4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54VD6-1", "protein_name": "Dynactin 150 kDa subunit", "gene_name": "dynA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSEEGKSLPPGTRVSINGKPELGLGTVKYCGMTKFSPGRWVGIELDSAAGKNDGTVQGERYFDCKPAHGLFVKPNMAVIVEEQPQTQTQPQPQQTSNIDDGIDDSKLMPAPITTPSKIAATSGIRPPSSTGIRPPSSLGKGRPSLTGSSSTTSSSSSSSSTTTTTTTPTSSIKKPSESGIRRPSTIPSSTTTTTSTTSTSPTSTSPLTSPPPEKKSEPSPPTTTTISPPPPTVVEPTPIEQPQPTPSKISRPPSSASSRPTGIPKPSGLKEPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPIITPNPTITTTTTPIPTPSTPLPPSTSNSITLTPPSTQKKQSKIIQGEDEEEEEEINDLLNKSLATERMNQAVQENIDKMMTTINDLKEDKNRSQEEINSLKDRLKEAVASKDKQIKENEKQIKENEKQIQQLEKTIAIKEKENENLLKTQHRNEDKEKSEFEKEKQSLLEQISNLNENLELLTLDKEVTEEKLEMTELEFEQVKEELEMMRIEYDSLKIQLDEKPTRSIDESLPTDVLVLQEQNDKLKEALVKLRDITMNDKHELSKKTKELETLSKQVQSLTEKSNKLEMELSIKIEETLELKLALEDAEVSESLITDLTDKNLSLNEELEELKVSIADLESFRDLSEELSENQVALEKSLRLEVNSKDIEILNIQSQMTNLQIKNQENEKTILQFRDLVGRLQHKLEEMRRKEEEQSEHQHSWSAIQQQLLSKNIQLQNQMIKATALEIDHQLEQSKSVESQVHLAFVYEYLPEQTFQLDNDAIKMLLLLKRIILKSELAQKYLNRTYKVEEIGNKVAGGDSDQMLLTSGQVAHSLSIIHILEHLAISTTWLTETLERSSSDQWLRSGRSIKDMLNQERILDNLLQLIKLEQFGSSYSSTDLEKLCQRIDSILTNIFGNITNSTNDSGSNNTSSNNNNNNNVDQIFKPEWSILLNYILGIQYNIKQIMLNDINITTTITHNDQFIFPHKEMSKVLSVCRKVVKNLLTKPYLSQSSIVRDLLKTSEHTCKSILLELVQSLPKIQDESINSGGGGSGSGSGNLNNNLNDLLIKIQARSDLIISNSNSLNKNNDEFSNDDYQDQEESKLSSSLEKVFYRMNVQLSDVVETIIAGDLNLSEKDKQALTKQSPWAERANQLKQSLGEVGQLRDIIQSKDAELLENLKTIKAKEAELIEEKRKEESFDKRIRILQKSENEVTEKLAKEIKSREDNEKNFRQALNLLRNEKNSLEHDSKNMQNKILALQQELQKKLNTPLSPMIANQELLRSVDDINVLSLKKAIRFLRNENLKLKSQKSIKELCELNLIQNYRHQQQIKQQQQQQSNNSSTSSTSSSTPTLLEQQAKKQQIKFNEIVEYSKQVNHMMSSILESTATPKVLDLSNKSISSSSSSSSSSNDRTSANEIEKQKLLIKQQERKVKQLQSKMTNFISSSTCQFGLNNYADANQSRMLKESIPLKIANITIPNLNINNINNNNNNTNSLMLDKDIQEALNSKTLSIQLFTNPQTFKEIHQVFVK", "length": 1539 }, "evidence": [ { "id": "A0A3Q1LQT4", "url": "https://omabrowser.org/oma/group/A0A3Q1LQT4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 21, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "cell leading edge", "id": "GO:0031252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031252", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "intercellular bridge", "id": "GO:0045171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045171", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "microtubule plus-end", "id": "GO:0035371", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035371", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "dynein complex", "id": "GO:0030286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030286", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "retromer complex", "id": "GO:0030904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030904", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "centriolar subdistal appendage", "id": "GO:0120103", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120103", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "microtubule associated complex", "id": "GO:0005875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005875", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 19, "go_terms": [ { "name": "mitotic nuclear membrane disassembly", "id": "GO:0007077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007077", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "neuromuscular junction development", "id": "GO:0007528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007528", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "neuromuscular process", "id": "GO:0050905", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050905", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "neuron cellular homeostasis", "id": "GO:0070050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070050", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "neuron projection maintenance", "id": "GO:1990535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990535", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "cholesterol homeostasis", "id": "GO:0042632", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042632", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "regulation of mitotic spindle organization", "id": "GO:0060236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060236", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "non-motile cilium assembly", "id": "GO:1905515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905515", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "establishment of mitotic spindle orientation", "id": "GO:0000132", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000132", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "centriole-centriole cohesion", "id": "GO:0010457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010457", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "microtubule anchoring at centrosome", "id": "GO:0034454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034454", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQT4" } ], "pmid": "" }, { "name": "positive regulation of microtubule nucleation", "id": "GO:0090063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090063", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQT4", "url": 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Transcript", "id": "ENSBTAT00000070685.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070685.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062281.3", "url": "https://www.ensembl.org/id/ENSBTAP00000062281.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513917", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513917", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQ58", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ58" } ], "pmid": "" }, { "name": "aspartic endopeptidase activity, intramembrane cleaving", "id": "GO:0042500", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042500", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQ58", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ58" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "fusion of sperm to egg plasma membrane involved in single fertilization", "id": "GO:0007342", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007342", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQ58", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ58" } ], "pmid": "" }, { "name": "intracellular calcium ion homeostasis", "id": "GO:0006874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006874", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQ58", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ58" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQ58", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ58" } ], "pmid": "" }, { "name": "membrane protein intracellular domain proteolysis", "id": "GO:0031293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031293", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQ58", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ58" } ], "pmid": "" }, { "name": "acrosome assembly", "id": "GO:0001675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001675", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQ58", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ58" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQ58", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ58" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": 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104 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 666, "end_pos": 668 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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"length": 1792, "header": "tr|A0A3Q1M0M9-1|A0A3Q1M0M9_BOVIN Isoform 1 of Methylcytosine dioxygenase TET OS=Bos taurus OX=9913 GN=TET3 PE=3 SV=1 CANONICAL=A0A3Q1M0M9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0M9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9/entry", "sequence": { "sequence": "MSQFQVPLAVQPDLPGLYDFPQGQVMVAGYQGPGLPVAGTEPQLRGGGDGRKKRKRCGTCEPCRRLENCGACTSCTNRRTHQICKLRKCEVLKKKVGLLKEVEIKAGEGAGPWGQGAAVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSASGAPVNGAREPAGPSLLGTGSPWQADQKPDWDTAPGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGDNSRGPRPGPESCSASSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSVVVEGGEERPRLPGTLPSGDAGLPAPVTGPLLNSEVPQMPPLEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHATSQASCPLPEALSPPAPFRSPQSYLGAPSWPVVPPEEHPSFAPDGPAFPAATPRTEFPEAWGTDTPPATPQSSWPMPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEVPSSSPSPVLQREAPTPSSEPDTHQKAQTALQQHLHHKRSLFLEQAHDASRPPPSELPAPGWWAPPSSPAPRPSDRPPKEKKKKPLTPAGGPLGADRAGPGIKPGVRKPVHIKKSRPREAQPLFPPLRQIILEGLRPPASEDVQAHPPAPVPTSQGSVVPLPPEPSLALFAPSPSGDSLLAPTQEMRSPSPVAALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQPTCLPAPESPFATRSPKQIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLAGDNPKEEEVLRKSFQDLATEVAPLYKRLAPQAYQNQVTNEEIAIDCRLGLKEGRPFSGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGKIPEDEQLHVLPLYKMASTDEFGSEENQNAKVGSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKVQKEKLSTPEKIKQEALELAGITTDPGLSLKGGLSQQSLKPSLKVEPQSPFSSFKYSGNTVVESYSVLGSCRPSDPYSVNSVYSYHSHYAQPGLAAVNGFHSKYALPAFSYYGFPSSNPVFPSQFLGAGAWGHGGGSSSFEKKPDLHALHNSLSPAYGGAEFAELPGQAVPTDTHHPASHHQQPAYPGPKEYLLPKAPQIHPVSRDPSPFAQSSNCYNRSIKQEPVDPLVHTESVTREPGKMGKTPLPEASQNGGPSHLWGQYSGGPSMSPKRTNGVGGSWGVFPPVESPAVIPDKLGSFGGSCLTPSHFPDGQHQWGLFPGEGQQPAPQPAGRLRGKPWSPCKFGSNASALAGPGLTEKPWGVGAGDFSSALKGGPGFQDKLWSPLKGEEGRIPTPGASQLDKAWQSFGMPLGPSEKLFGALKSEEKLWDPFSLEEGTAEGPPNKGTVKEEKGAGGAEEEEELWSDSEHNFLDENIGGVAVAPAHGSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARARQEEAARLGLGHQEAKLYGKKRKWGGAVVPESQHKEKKGMVPTRQALAMPTDSAVTVSSYAYTKVTGPYSRWI", "length": 1792, "header": "tr|A0A3Q1M0M9-1|A0A3Q1M0M9_BOVIN Isoform 1 of Methylcytosine dioxygenase TET OS=Bos taurus OX=9913 GN=TET3 PE=3 SV=1 CANONICAL=A0A3Q1M0M9-1" }, "locus": { "chromosome": "11", "start_pos": 10665047, "end_pos": 10561672, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067050.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067050.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066775.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066775.1" } ] } }, { "isoform_ac": "A0A3Q1NK48-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NK48/entry", "sequence": { "sequence": "MVESLVFSAGQPGLESQSCCFLAVSPWVEIKAGEGAGPWGQGAAVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSASGAPVNGAREPAGPSLLGTGSPWQADQKPDWDTAPGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGDNSRGPRPGPESCSASSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSVVVEGGEERPRLPGTLPSGDAGLPAPVTGPLLNSEVPQMPPLEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHATSQASCPLPEALSPPAPFRSPQSYLGAPSWPVVPPEEHPSFAPDGPAFPAATPRTEFPEAWGTDTPPATPQSSWPMPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEVPSSSPSPVLQREAPTPSSEPDTHQKAQTALQQHLHHKRSLFLEQAHDASRPPPSELPAPGWWAPPSSPAPRPSDRPPKEKKKKPLTPAGGPLGADRAGPGIKPGVRKPVHIKKSRPREAQPLFPPLRQIILEGLRPPASEDVQAHPPAPVPTSQGSVVPLPPEPSLALFAPSPSGDSLLAPTQEMRSPSPVAALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQPTCLPAPESPFATRSPKQIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLAGDNPKEEEVLRKSFQDLATEVAPLYKRLAPQAYQNQVTNEEIAIDCRLGLKEGRPFSGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGKIPEDEQLHVLPLYKMASTDEFGSEENQNAKVGSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKVQKEKLSTPEKIKQEALELAGITTDPGLSLKGGLSQQSLKPSLKVEPQSPFSSFKYSGNTVVESYSVLGSCRPSDPYSVNSVYSYHSHYAQPGLAAVNGFHSKYALPAFSYYGFPSSNPVFPSQFLGAGAWGHGGGSSSFEKKPDLHALHNSLSPAYGGAEFAELPGQAVPTDTHHPASHHQQPAYPGPKEYLLPKAPQIHPVSRDPSPFAQSSNCYNRSIKQEPVDPLVHTESVTREPGKMGKTPLPEASQNGGPSHLWGQYSGGPSMSPKRTNGVGGSWGVFPPVESPAVIPDKLGSFGGSCLTPSHFPDGQHQWGLFPGEGQQPAPQPAGRLRGKPWSPCKFGSNASALAGPGLTEKPWGVGAGDFSSALKGGPGFQDKLWSPLKGEEGRIPTPGASQLDKAWQSFGMPLGPSEKLFGALKSEEKLWDPFSLEEGTAEGPPNKGTVKEEKGAGGAEEEEELWSDSEHNFLDENIGGVAVAPAHGSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARARQEEAARLGLGHQEAKLYGKKRKWGGAVVPESQHKEKKGMVPTRQALAMPTDSAVTVSSYAYTKVTGPYSRWI", "length": 1718, "header": "tr|A0A3Q1NK48-1|A0A3Q1M0M9_BOVIN Computationally mapped isoform of Methylcytosine dioxygenase TET OS=Bos taurus OX=9913 GN=TET3 PE=3 SV=2 CANONICAL=A0A3Q1M0M9-1" }, "locus": { "chromosome": "11", "start_pos": 10650364, "end_pos": 10561672, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080158.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080158.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072621.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072621.2" } ] } }, { "isoform_ac": "F1MJY3-1", "url": "https://www.uniprot.org/uniprotkb/F1MJY3/entry", "sequence": { "sequence": "MHQRRPAEVEIKAGEGAGPWGQGAAVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSASGAPVNGAREPAGPSLLGTGSPWQADQKPDWDTAPGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGDNSRGPRPGPESCSASSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSVVVEGGEERPRLPGTLPSGDAGLPAPVTGPLLNSEVPQMPPLEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHATSQASCPLPEALSPPAPFRSPQSYLGAPSWPVVPPEEHPSFAPDGPAFPAATPRTEFPEAWGTDTPPATPQSSWPMPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEVPSSSPSPVLQREAPTPSSEPDTHQKAQTALQQHLHHKRSLFLEQAHDASRPPPSELPAPGWWAPPSSPAPRPSDRPPKEKKKKPLTPAGGPLGADRAGPGIKPGVRKPVHIKKSRPREAQPLFPPLRQIILEGLRPPASEDVQAHPPAPVPTSQGSVVPLPPEPSLALFAPSPSGDSLLAPTQEMRSPSPVAALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQPTCLPAPESPFATRSPKQIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLAGDNPKEEEVLRKSFQDLATEVAPLYKRLAPQAYQNQVTNEEIAIDCRLGLKEGRPFSGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGKIPEDEQLHVLPLYKMASTDEFGSEENQNAKVGSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKVQKEKLSTPEKIKQEALELAGITTDPGLSLKGGLSQQSLKPSLKVEPQSPFSSFKYSGNTVVESYSVLGSCRPSDPYSVNSVYSYHSHYAQPGLAAVNGFHSKYALPAFSYYGFPSSNPVFPSQFLGAGAWGHGGGSSSFEKKPDLHALHNSLSPAYGGAEFAELPGQAVPTDTHHPASHHQQPAYPGPKEYLLPKAPQIHPVSRDPSPFAQSSNCYNRSIKQEPVDPLVHTESVTREPGKMGKTPLPEASQNGGPSHLWGQYSGGPSMSPKRTNGVGGSWGVFPPVESPAVIPDKLGSFGGSCLTPSHFPDGQHQWGLFPGEGQQPAPQPAGRLRGKPWSPCKFGSNASALAGPGLTEKPWGVGAGDFSSALKGGPGFQDKLWSPLKGEEGRIPTPGASQLDKAWQSFGMPLGPSEKLFGALKSEEKLWDPFSLEEGTAEGPPNKGTVKEEKGAGGAEEEEELWSDSEHNFLDENIGGVAVAPAHGSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARARQEEAARLGLGHQEAKLYGKKRKWGGAVVPESQHKEKKGMVPTRQALAMPTDSAVTVSSYAYTKVTGPYSRWI", "length": 1699, "header": "tr|F1MJY3-1|A0A3Q1M0M9_BOVIN Computationally mapped isoform of Methylcytosine dioxygenase TET OS=Bos taurus OX=9913 GN=TET3 PE=3 SV=3 CANONICAL=A0A3Q1M0M9-1" }, "locus": { "chromosome": "11", "start_pos": 10649688, "end_pos": 10561672, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047352.4", "url": "https://www.ensembl.org/id/ENSBTAT00000047352.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044564.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044564.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 509, "start_aa": "Thr", "end_pos": 509, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr509", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 847, "start_aa": "Thr", "end_pos": 847, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr847", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:101904937", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101904937", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A2R8Q4R6-1", "protein_name": "Methylcytosine dioxygenase TET", "gene_name": "tet3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MHKLRGGPGPPVQDIYEFSLDEEDPKVFLGARSARVVSPADDYIRSEHEQAGMFSLSQMEDQEPIEPVVAQKKKRKRCGVCGPCMRKENCGTCSNCLNRKIGHQICKLRKCDELKRKKSPWEVEYFEDKNTQPVIPNLAKETVSVVGSVDGPRGKGQMEIGSHERLEEGLLNQELSNGLSKHASNEENVCDNEDRDATKEQHQHNFHEGAGSISQTPGWVLEHTGKLSNPESQQGVWSGQNASTTVNDVDMEDAQTLVAFSVGSLPPYTNHQPSPTPTAQLYERFNQEMSNGGEEAKKKGVDGAFCPPEDLNTLQAALSKARHGHKPPNCDCDGPDCPDYLEWLEKQIKLVTNCQNKTSCNLSGTAQQPLEQHHYSQSQPQQCGGKPLCVQDTNPQPLVNKPSTPRPFGPPAPIPCSPSVLSIAKERNVSLQTAIAIEALTQLSATVPQTVVPPGESSLANHHQHLPTSYHQNMPQVVSSSPGPLLSSSATSAIPQSNHYPQQELTTWEQQRPQSKGEAPTANIFPSSSHYSSSYPSSKPPFTNMHASSPNPRPQQWNQGTASSCEKNSPRNAWMMANTDSKQHFAKPSHESSDPVSELKQLLGDTGGKHPFKFPFPHPSLQDVHKGSFTGMPHIKQEVETKEYLGSECSVMGQEGMLNGQQQFQGQQLSSTIRHSTQAALQQHLHHKRNLFSNSPTYGPLAHMACQDLRKWWPQTIPENLINIKQEHKEPKKKKGAQSSHLKQPAGGPFGPLGTPLPKPKPIVIKKHKQKASQPTFLPQIQITISKPPLISPGYAPSRAQLVPSLPGMEAGLPPTQVAESHPAPAQSQESIINCSSAPISENSHSSTNPVSVLAPSTQKVIACPGSAGSNDSIPTTSITPQTSTTQPSPSLAGLSNLDPKFEELIRQFEEEFGDTAASAAETPENGPVQPVVTESHPNSGQLRPESPSLKQPNNCPPVPTNESEPMNEGQKDIPERQKEKTPLPPEELCTVKQESEECALDVKPSGELLSEFLKQQNPFVAPFSPPNKRMKIESSNGVTVLSTTACFSADREGDDFNTPTKDIFPSSPSLKGFLESPLRYLDTPTKNLLDTPGKDVQPDFPICDCVDQVLEKDEGPYYNHLGSGRDIPSVRQLMEDRYGEKGEAVRIEKVVYTGREGKSSQGCPIAKWVLRRSSEKEKVLCVVKQRPGHHCANTVIVVVILAWEGVPRALGDKLYREVTETITKYGNPTSRRCGLNEDRTCACQGKDPETCGASFSFGCSWSMYFNGCKYARSKVPRKFRLQGEHPKEEDNLRDNFQALATHVAPLYKKLAPQAYSNQCLHEDVASDCRLGLKEGRPFSGITACMDFCAHAHKDQHNLHNGCTVVCTLTKEDNRTVGTIPEDEQLHVLPLYKLATTDEFGSEENQRLKMQTGAIQVLANFRREVRKLPEPAKSCRQRRLEAKKAASEKKNRKLQLAETPEKTVKMEIRHAESPHIQQGNKAIPKQEVKPTIKKEPVDHFQPFNGAIHGYQALGNGKTNPDPHNMNSSFSYPGNYARGRIPGNSHPPAQNPINGFHPNLQDIRYGYYNYPSSALFSPELLRYDKGAWPKNGEPSAQAFEQKPDVQCLQANLAQAYPTHHGQSQAQMADASIQGYPQPSDISQCRTPSMSLEQTHRSKPIVKQEPMDVPLYEARSDGQAQSCPTTPSTTPTPEGWHGHKPNGSLVPKGWDGNIRAASNNSPFTPDKQRLHQQHQHEHPQYPQQQQWNSYSCPNTPMASPAPSPSPSLKAGLSPAPSPHPSTPRQWGSPAPSPQPKAWGPYGPMGYGAGVIRQGNPAGAYPDNMLSQAGVNCGSAPLGLQEKAWKSGGGSAAGSTPSPAPEGRLFPDALQRSDGQACWDSGAETQSERDPEEDEVWSDSEHNFLDPNIGGVAVAPAHGCVLIECARRELHATTPLKKPDRTHPSRISLVFYQHKNLNQPCHGLALWESKMKILAERARQRQQEAALLGLSQEEIKAYGKKRKWAAGSASPSPGQTKDKREGVVTRMAPTQHSTTIVTVSPYPSTHLTGPYSRFV", "length": 2052 }, "evidence": [ { "id": "A0A3Q1M0M9", "url": "https://omabrowser.org/oma/group/A0A3Q1M0M9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8C2QLK7-1", "protein_name": "Methylcytosine dioxygenase TET", "gene_name": "Tet3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSQFQVPLAVQPDLPGLYEYPQGQVMVGGFQGPGLPMTGSETQLRGGGDGRKKRKRCGTCEPCRRLENCGSCTSCTNRRTHQICKLRKCEVLKKKVGLLKEVEIKAGEGTGPWAQGATVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSTSGAPVNGAREPAGPSLLGATGPWRVDQKPDWDAASGSAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGNSSRGARPESCSEGSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSVAMEGGQERPRLPGTLPPGEAGLPAPSNRPLLSSEVPQAPPLEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTSQASCPLPEALSPSAPFRSPQSYLRAPSWPVVPPEEHPSFAPDSPAFPPATPRTEFPEAWGTDTPPATPRNSWPAPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPSSSPAPVPSPLSQREAPLPSSEPDAHQKAQTALQQHLHHKRSLFLEQAHDASFPAPTEPQAPGWWAPPGSPAPRPPDKPSKEKKKKPPTPAGGPVGAEKTTPGIKPSVRKPIQIKKSRSRDMQPVFLPLRQIVLEGLKPQPSEEVQAPPPAQLSALPPASQGAASQSSAAPLPPEPSLALFAPSPSGDSLLPPTQEMRSPSPMAVLQPGSTSGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQSTCLPAPESPFATRSPKKIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRGTLEEKLLCLVRHRAGHHCQNAVIIILILAWEGIPRSLGDALYRELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLTGDNPKEEEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEEVAIDCRLGLKEGRPFSGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGQIPEDEQLHVLPLYKMANTDEFGSEENQNAKVSSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKLQKEKLSTPEKIKQEALELAGVTTDPGLSLKGGLSQQSLKPSLKVEPQNHFSSFKYSSNAVVESYSVLGSCRPSDPYSMSSVYSYHSRYAQPGLASVNGFHSKYTLPSFGYYGFPSSNPVFSSQFLGPSTWGHGGSGTSFEKKPDLHALHNSLNPAYGGAEFAELPGQAVSTDTHHPTPHHQQPAYPGPKEYLLPKVPQLHPASRDPSPFAQSSNCYNRSIKQEPVDPLTQAESVPRDSGKMGSRTPLPEASQNGGPSHLWGQYSGGPSMSPKRTNSIGGNWGVFPSGESPTIVPDKLNSFGASCLTPSHFPDSQWGLFTGEGQQSAPHPGGRLRGKPWSPCKFGNSTSALTGSSLSEKPWGVGTGDFNSTLKGGPGFQDKLWNPVKVEEGRIPTPGASQLDKTWQAFGMPLGSSEKLFGALKSEEKLWDPFSLEEGTAEEPPSKGVKEEKSGPGVEEEEEELWSDSEHNFLDENIGGVAVAPAHCSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARQRQEEAARLGLGQQEAKLYGKKRKWGGAMVAEPQHKEKKGAVPTRQALAMPTDSAVTVSSYAYTKVTGPYSRWI", "length": 1803 }, "evidence": [ { "id": "A0A3Q1M0M9", "url": "https://omabrowser.org/oma/group/A0A3Q1M0M9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZQT7-1", "protein_name": "Methylcytosine dioxygenase TET", "gene_name": "Tet3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQFQVPLAVQPDLSGLYDFPQGQVMVGGFQGPGLPMAGSETQLRGGGDGRKKRKRCGTCDPCRRLENCGSCTSCTNRRTHQICKLRKCEVLKKKAGLLKEVEINAREGTGPWAQGATVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSTSGAPVNGAREPAGPSLLGAAGPWRVDQKPDWDAASGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGNNGRAPRPESCSEGGEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSAAMEGGQGRPRLPGTLPPSEAGLPAPSTRPLLSSEVPQVPPLEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTSQASCPLPEALSPSAPFRSPQSYLRAPSWPVVPPEEHPSFAPDSPAFPPATPRTEFSEAWSTDTPPATPRNSWPVPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPPSSPAPAPSPISQREAPLPSSEPDTHQKAQTALQQHLHHKRNLFLEQAHDASFPTSTEPQAPGWWAPPGSPAPRPPDKPPKEKKKKPPTPAGGPVGAEKTTPGIKASVRKPIQIKKSRSRDMQPLFLPVRQIILEGLKPQASEGQAPTPAQLPVPPPASQGAASQSCATPLPPEPSLALFAPSPSGDSLLPPTQEMRSPSPMVALQSGSTGGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQSTCLPTPESPFATRSPKKIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKKAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEDRYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLTGDNPKEEEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEDVAIDCRLGLKEGRPFSGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGQIPEDEQLHVLPLYKMATTDEFGSEENQNAKVSSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKLQKEKLSTPEKIKQEALELAGVTTDPGLSLQGGLPQQTLKPSLKVEPQNHFSSFKYSGNAVVESYSVLGSCRPSDPYSMSSVYSYHSRYAQPGLASVNGFHSKYTLPSFGYYGFPSSNPVFPSQFLGPSAWGHGGGGGSFEKKPDLHALHNSLNPAYGGAEFAELPGQAVSTDNHHPAPHHQQPAYPGPKEYLLPKVPQLHPASRDPSPFAQSSGCYNRSIKQEPVDPLTQAEAVPRDSGKMSRTPLPEASQNGGPGHLWGQYSGGPSMSPKRTNSVGGNWGVFPSGESPTIVPDKLNSFGASCLTPSHFPDSQWGLFTGEGQQSAPHPGGRLRGKPWSPCKFGNGTSALSGPSLPEKPWGMGAGDFNSSLKGGPGFQDKLWNPVKVEEGRIPTPGANQLEKAWQAFGMPLSSNEKLFGALKSEEKLWDPFSLEEGTAEEPLSKGVVKEEKTGPGVEEDEEELWSDSEHNFLDENIGGVAVAPAHCSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARQRQEEAARLGLGQQEAKLYGKKRKWGGAMVAEPQHKEKKGAVPTRQALAMPTDSAVTVSSYAYTKVTGPYSRWI", "length": 1802 }, "evidence": [ { "id": "A0A3Q1M0M9", "url": "https://omabrowser.org/oma/group/A0A3Q1M0M9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O43151-1", "protein_name": "Methylcytosine dioxygenase TET3", "gene_name": "TET3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"length": 1795 }, "evidence": [ { "id": "A0A3Q1M0M9", "url": "https://omabrowser.org/oma/group/A0A3Q1M0M9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BG87-1", "protein_name": "Methylcytosine dioxygenase TET3", "gene_name": "Tet3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"length": 1803 }, "evidence": [ { "id": "A0A3Q1M0M9", "url": "https://omabrowser.org/oma/group/A0A3Q1M0M9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" }, { "name": "DNA 5-methylcytosine dioxygenase activity", "id": "GO:0070579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070579", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" }, { "name": "methyl-CpG binding", "id": "GO:0008327", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008327", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" }, { "name": "female pronucleus", "id": "GO:0001939", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001939", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" }, { "name": "male pronucleus", "id": "GO:0001940", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001940", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" }, { "name": "epigenetic regulation of gene expression", "id": "GO:0040029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0040029", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" }, { "name": "chromosomal 5-methylcytosine DNA demethylation pathway", "id": "GO:0141166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141166", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" }, { "name": "positive regulation of macromolecule biosynthetic process", "id": "GO:0010557", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010557", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" }, { "name": "protein O-linked glycosylation", "id": "GO:0006493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006493", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" }, { "name": "epigenetic programing of male pronucleus", "id": "GO:0044727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044727", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1389, "end_pos": 1391, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1519, "end_pos": 1521, "annotation": "n_glycosylation_sequon" }, { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "52636", "name": "", "equation": "a 5-methyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + succinate + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M0M9-1", "F1MGK2-1", "E1BD99-1" ], "evidence": [ { "id": "52636", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52636" } ] }, { "id": "53828", "name": "", "equation": "a 5-hydroxymethyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-formyl-2'-deoxycytidine in DNA + succinate + CO2 + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M0M9-1", "F1MGK2-1", "E1BD99-1" ], "evidence": [ { "id": "53828", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53828" } ] }, { "id": "53832", "name": "", "equation": "a 5-formyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + succinate + CO2 + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M0M9-1", "F1MGK2-1", "E1BD99-1" ], "evidence": [ { "id": "53832", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53832" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M0M9", "gene_name": "TET3", "activity": [ { "ec_number": "1.14.11.80", "activity": "a 5-hydroxymethyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-formyl-2'-deoxycytidine in DNA + succinate + CO2 + H2O.", "evidence": [ { "id": "A0A3Q1M0M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ] }, { "ec_number": "1.14.11.80", "activity": "", "evidence": [ { "id": "A0A3Q1M0M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" } ] } ] }, { "uniprot_ac": "E1BD99", "gene_name": "TET2", "activity": [ { "ec_number": "1.14.11.80", "activity": "a 5-hydroxymethyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-formyl-2'-deoxycytidine in DNA + succinate + CO2 + H2O.", "evidence": [ { "id": "E1BD99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD99" } ] }, { "ec_number": "1.14.11.80", "activity": "", "evidence": [ { "id": "E1BD99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BD99" } ] } ] }, { "uniprot_ac": "F1MGK2", "gene_name": "TET1", "activity": [ { "ec_number": "1.14.11.80", "activity": "a 5-hydroxymethyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-formyl-2'-deoxycytidine in DNA + succinate + CO2 + H2O.", "evidence": [ { "id": "F1MGK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK2" } ] }, { "ec_number": "1.14.11.80", "activity": "", "evidence": [ { "id": "F1MGK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK2" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M0M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M9" }, { "id": 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"field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LZB9-1", "uniprot_ac": "A0A3Q1LZB9", "uniprot_id": "A0A3Q1LZB9_BOVIN", "mass": { "chemical_mass": 134532.0, "monoisotopic_mass": 134532.0 }, "refseq": { "ac": "XP_005208842", "name": "calmodulin-regulated spectrin-associated protein 3 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208842" }, "gene_names": [ { "name": "CAMSAP3", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ] }, { "name": "CAMSAP3", "type": "synonym", "evidence": [ { "id": "XP_005208842", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208842" } ] } ], "protein_names": [ { "name": "Calmodulin regulated spectrin associated protein family member 3", "type": "synonym", "evidence": [ { "id": "A0A3Q1LZB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9/entry#names_and_taxonomy" } ] }, { "name": "calmodulin-regulated spectrin-associated protein 3 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_005208842", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208842" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CAMSAP3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9", "locus": { "chromosome": "7", "start_pos": 16464459, "end_pos": 16447774, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011356", "url": "https://www.ensembl.org/id/ENSBTAG00000011356" } ] } } ], "crossref": [ { "id": "A0A3Q1LZB9", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LZB9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011356", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011356", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616206", "url": "https://www.ncbi.nlm.nih.gov/gene/616206", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022613", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022613", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038209", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038209", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058042", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058042", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616206", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616206", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HQPILMX", "url": "https://omabrowser.org/oma/group/HQPILMX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZB9", "url": "https://www.orthodb.org/?gene=A0A3Q1LZB9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MTR8", "url": "https://www.orthodb.org/?gene=A0A3Q1MTR8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BPZ9", "url": "https://www.orthodb.org/?gene=E1BPZ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21595", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21595", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21595:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21595:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08683", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08683", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11971", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11971", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17095", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17095", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25532", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25532", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005208842", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208842", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZB9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTR8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTR8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPZ9", "url": "https://www.uniprot.org/uniprotkb/E1BPZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPZ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BPZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPSELWEPFYTDQYAQEHVKPPVTRLLFSAELYCRAWRQALPQLEAPPSPSALLALLARRGTVPALPERPVQEADLRHQPILMGAHLAVIDALMVAFAFEWTKTLPGPLALASLEHKLLFWVDTTIRRLQEKTEQEAAQRATPAAPADGVAPAQPSIRYRKDRAVARRAPCFPTVTSLQDLASGAALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDFCASRLPRGCPLSLEDLLYVPPPLKVNLMVLLAELFMCFEVLKPDFVQVKDLPDGHAASPQATEASTPQNSGSSSPVFNFRHPLLSPGGPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPQRPVPARTPAQPPPETGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGSSKLPLASPYPLEGSSKPLPDGPTKVPAYLPHPEGPSKPAPCPAGEVSKPPALPEGSPKVAASSPAASNSEVKMTSFAERKKQLVKAEVEAGSPVATPGAPEALSSEMSELGARLEEKRRAIEAQKRRIEAIFAKHRQRLGKNAFLQVQPREAGGEAEAELGPAPGGERPAGEGQGEPSPRPKAVTFSPELGPVPPEGLGDYNRAVSKLSAALNSLQRDMQRLTDQQQRLLAPPESSTVAPTPAAAAWVIPGPTAGPKAASPSPARRAPAARRSHGPGPSPGPSPTPRSPKHARPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEGPPPEEPAARPGLIEIPLSSLEEPAAEDEGDGSPPGAEDSLEEEVSSEGEPRTGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEAEKEQRREEASRLVQEEVTPSPPAPTAPTASAAIPAPAARAPAEEEVGPRRGEFTRLEYERRAQLKLMDDLDKVLRPRAAGSGGPGRGGRRAPRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVANEGPSNLGVKRPTSRAPSPSGLMSPSRLPGSREREWDNGSNASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSSCQFRALYTLSAETEELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLWQSKKPTTPKKGSSTPK", "length": 1249, "header": "tr|A0A3Q1LZB9-1|A0A3Q1LZB9_BOVIN Isoform 1 of Calmodulin regulated spectrin associated protein family member 3 OS=Bos taurus OX=9913 GN=CAMSAP3 PE=3 SV=1 CANONICAL=A0A3Q1LZB9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZB9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9/entry", "sequence": { "sequence": "MVEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPSELWEPFYTDQYAQEHVKPPVTRLLFSAELYCRAWRQALPQLEAPPSPSALLALLARRGTVPALPERPVQEADLRHQPILMGAHLAVIDALMVAFAFEWTKTLPGPLALASLEHKLLFWVDTTIRRLQEKTEQEAAQRATPAAPADGVAPAQPSIRYRKDRAVARRAPCFPTVTSLQDLASGAALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDFCASRLPRGCPLSLEDLLYVPPPLKVNLMVLLAELFMCFEVLKPDFVQVKDLPDGHAASPQATEASTPQNSGSSSPVFNFRHPLLSPGGPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPQRPVPARTPAQPPPETGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGSSKLPLASPYPLEGSSKPLPDGPTKVPAYLPHPEGPSKPAPCPAGEVSKPPALPEGSPKVAASSPAASNSEVKMTSFAERKKQLVKAEVEAGSPVATPGAPEALSSEMSELGARLEEKRRAIEAQKRRIEAIFAKHRQRLGKNAFLQVQPREAGGEAEAELGPAPGGERPAGEGQGEPSPRPKAVTFSPELGPVPPEGLGDYNRAVSKLSAALNSLQRDMQRLTDQQQRLLAPPESSTVAPTPAAAAWVIPGPTAGPKAASPSPARRAPAARRSHGPGPSPGPSPTPRSPKHARPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEGPPPEEPAARPGLIEIPLSSLEEPAAEDEGDGSPPGAEDSLEEEVSSEGEPRTGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEAEKEQRREEASRLVQEEVTPSPPAPTAPTASAAIPAPAARAPAEEEVGPRRGEFTRLEYERRAQLKLMDDLDKVLRPRAAGSGGPGRGGRRAPRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVANEGPSNLGVKRPTSRAPSPSGLMSPSRLPGSREREWDNGSNASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSSCQFRALYTLSAETEELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLWQSKKPTTPKKGSSTPK", "length": 1249, "header": "tr|A0A3Q1LZB9-1|A0A3Q1LZB9_BOVIN Isoform 1 of Calmodulin regulated spectrin associated protein family member 3 OS=Bos taurus OX=9913 GN=CAMSAP3 PE=3 SV=1 CANONICAL=A0A3Q1LZB9-1" }, "locus": { "chromosome": "7", "start_pos": 16464186, "end_pos": 16447973, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073186.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073186.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061046.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061046.1" } ] } }, { "isoform_ac": "A0A3Q1MTR8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTR8/entry", "sequence": { "sequence": "MVEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPSELWEPFYTDQYAQEHVKPPVTRLLFSAELYCRAWRQALPQLEAPPSPSALLALLARRGTVPALPERPVQEADLRHQPILMGAHLAVIDALMVAFAFEWTKTLPGPLALASLEHKLLFWVDTTIRRLQEKTEQEAAQRATPAAPADGVAPAQPSHAIAFCLKESGSKPPMIRYRKDRAVARRAPCFPTVTSLQDLASGAALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDFCASRLPRGCPLSLEDLLYVPPPLKVNLMVLLAELFMCFEVLKPDFVQVKDLPDGHAASPQATEASTPQNSGSSSPVFNFRHPLLSPGGPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPQRPVPARTPAQPPPETGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGSSKLPLASPYPLEGSSKPLPDGPTKVPAYLPHPEGPSKPAPCPAGEVSKPPALPEGSPKVAASSPAASNSEVKMTSFAERKKQLVKAEVEAGSPVATPGAPEALSSEMSELGARLEEKRRAIEAQKRRIEAIFAKHRQRLGKNAFLQVQPREAGGEAEAELGPAPGGERPAGEGQGEPSPRPKAVTFSPELGPVPPEGLGDYNRAVSKLSAALNSLQRDMQRLTDQQQRLLAPPESSTVAPTPAAAAWVIPGPTAGPKAASPSPARRAPAARRSHGPGPSPGPSPTPRSPKHARPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEGPPPEEPAARPGLIEIPLSSLEEPAAEDEGDGSPPGAEDSLEEEVSSEGEPRTGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEAEKEQRREEASRLVQEEVTPSPPAPTAPTASAAIPAPAARAPAEEEVGPRRGEFTRLEYERRAQLKLMDDLDKVLRPRAAGSGGPGRGGRRAPRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVANEGPSNLGVKRPTSRAPSPSGLMSPSRLPGSREREWDNGSNASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSSCQFRALYTLSAETEELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLWQSKKPTTPKKGSSTPK", "length": 1265, "header": "tr|A0A3Q1MTR8-1|A0A3Q1LZB9_BOVIN Computationally mapped isoform of Calmodulin regulated spectrin associated protein family member 3 OS=Bos taurus OX=9913 GN=CAMSAP3 PE=3 SV=1 CANONICAL=A0A3Q1LZB9-1" }, "locus": { "chromosome": "7", "start_pos": 16464186, "end_pos": 16447973, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084631.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084631.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073763.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073763.1" } ] } }, { "isoform_ac": "E1BPZ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BPZ9/entry", "sequence": { "sequence": "MVEAAPPGPGPLRRTFLVPEIKSLDQYDFSRAKAAASLAWVLRAAFGGAEHVPSELWEPFYTDQYAQEHVKPPVTRLLFSAELYCRAWRQALPQLEAPPSPSALLALLARRGTVPALPERPVQEADLRHQPILMGAHLAVIDALMVAFAFEWTKTLPGPLALASLEHKLLFWVDTTIRRLQEKTEQEAAQRATPAAPADGVAPAQPSCPTRWYWKLVPHAIAFCLKESGSKPPMIRYRKDRAVARRAPCFPTVTSLQDLASGAALAATIHCYCPQLLRLEEVCLKDPMSVADSLYNLQLVQDFCASRLPRGCPLSLEDLLYVPPPLKVNLMVLLAELFMCFEVLKPDFVQVKDLPDGHAASPQATEASTPQNSGSSSPVFNFRHPLLSPGGPQSPLRGSTGSLKSSPSMSHMEALGKAWNRQLSRPLSQAVSFSTPFGLDSDVDVVMGDPVLLRSVSSDSLGPQRPVPARTPAQPPPETGDLPTIEEALQIIHSAEPRLLPDGAADGSFYLHSPEGSSKLPLASPYPLEGSSKPLPDGPTKVPAYLPHPEGPSKPAPCPAGEVSKPPALPEGSPKVAASSPAASNSEVKMTSFAERKKQLVKAEVEAGSPVATPGAPEALSSEMSELGARLEEKRRAIEAQKRRIEAIFAKHRQRLGKNAFLQVQPREAGGEAEAELGPAPGGERPAGEGQGEPSPRPKAVTFSPELGPVPPEGLGDYNRAVSKLSAALNSLQRDMQRLTDQQQRLLAPPESSTVAPTPAAAAWVIPGPTAGPKAASPSPARRAPAARRSHGPGPSPGPSPTPRSPKHARPAELRLAPLTRVLTPPHDVDSLPHLRKFSPSQVPVQTRSSILLAEGPPPEEPAARPGLIEIPLSSLEEPAAEDEGDGSPPGAEDSLEEEVSSEGEPRTGLGFFYKDEDKPEDEMAQKRASLLERQQRRAEEARRRKQWQEAEKEQRREEASRLVQEEVTPSPPAPTAPTASAAIPAPAARAPAEEEVGPRRGEFTRLEYERRAQLKLMDDLDKVLRPRAAGSGGPGRGGRRAPRPRSGCCDDSALARSPARGLLGSRLSKIYSQSTLSLSTVANEGPSNLGVKRPTSRAPSPSGLMSPSRLPGSREREWDNGSNASSPASVPEYTGPRLYKEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSSCQFRALYTLSAETEELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQIPAKTMSMSVDAFTIQGHLWQSKKPTTPKKGSSTPK", "length": 1276, "header": "tr|E1BPZ9-1|A0A3Q1LZB9_BOVIN Computationally mapped isoform of Calmodulin regulated spectrin associated protein family member 3 OS=Bos taurus OX=9913 GN=CAMSAP3 PE=3 SV=2 CANONICAL=A0A3Q1LZB9-1" }, "locus": { "chromosome": "7", "start_pos": 16464186, "end_pos": 16447973, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015094.5", "url": "https://www.ensembl.org/id/ENSBTAT00000015094.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015094.4", "url": "https://www.ensembl.org/id/ENSBTAP00000015094.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1194, "start_aa": "Thr", "end_pos": 1194, "end_aa": "Thr", "residue": "Thr", 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"url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 775, "start_aa": "Thr", "end_pos": 775, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr775", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 949, "start_aa": "Thr", "end_pos": 949, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr949", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616206", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616206", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q80VC9-1", "protein_name": "Calmodulin-regulated spectrin-associated protein 3", "gene_name": "Camsap3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"length": 1252 }, "evidence": [ { "id": "A0A3Q1LZB9", "url": "https://omabrowser.org/oma/group/A0A3Q1LZB9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P1Y5-1", "protein_name": "Calmodulin-regulated spectrin-associated protein 3", "gene_name": "CAMSAP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"length": 1249 }, "evidence": [ { "id": "A0A3Q1LZB9", "url": "https://omabrowser.org/oma/group/A0A3Q1LZB9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 15, "go_terms": [ { "name": "regulation of focal adhesion assembly", "id": "GO:0051893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051893", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "embryo development ending in birth or egg hatching", "id": "GO:0009792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009792", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "protein transport along microtubule", "id": "GO:0098840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098840", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "neuron projection development", "id": "GO:0031175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031175", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "establishment of epithelial cell apical/basal polarity", "id": "GO:0045198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045198", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "regulation of microtubule polymerization", "id": "GO:0031113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031113", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "negative regulation of microtubule depolymerization", "id": "GO:0007026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007026", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "cilium movement", "id": "GO:0003341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003341", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "microtubule anchoring", "id": "GO:0034453", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034453", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "cytoplasmic microtubule organization", "id": "GO:0031122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031122", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "zonula adherens maintenance", "id": "GO:0045218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045218", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "epithelial cell-cell adhesion", "id": "GO:0090136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090136", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "establishment or maintenance of microtubule cytoskeleton polarity", "id": "GO:0030951", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030951", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "regulation of Golgi organization", "id": "GO:1903358", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903358", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "spectrin binding", "id": "GO:0030507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030507", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "microtubule minus-end binding", "id": "GO:0051011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051011", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "microtubule minus-end", "id": "GO:0036449", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036449", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "zonula adherens", "id": "GO:0005915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005915", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1094, "end_pos": 1096, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1097, "end_pos": 1099, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LZB9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1249, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LZB9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LZB9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LZB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" }, { "id": "PS51508", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51508" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CKK", "eco_id": "ECO_0000259", "start_pos": 1109, "end_pos": 1243, "start_aa": "Gly", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LZB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZB9" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 203, "end_pos": 312, "start_aa": "Pro", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 586, 731, 743, 775, 949, 1194 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1094, "end_pos": 1096 }, { "start_pos": 1097, "end_pos": 1099 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 6 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_o_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 6 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_o_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPE8-1", "uniprot_ac": "E1BPE8", "uniprot_id": "E1BPE8_BOVIN", "mass": { "chemical_mass": 103627.0, "monoisotopic_mass": 103627.0 }, "refseq": {}, "gene_names": [ { "name": "LPIN1", "type": "recommended", "evidence": [ { "id": "E1BPE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ] } ], "protein_names": [ { "name": "phosphatidate phosphatase", "type": "recommended", "evidence": [ { "id": "E1BPE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPE8/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.4", "type": "synonym", "evidence": [ { "id": "E1BPE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPE8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPE8", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LPIN1", "url": "https://www.uniprot.org/uniprotkb/E1BPE8", "locus": { "chromosome": "11", "start_pos": 86081383, "end_pos": 86217519, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007689", "url": "https://www.ensembl.org/id/ENSBTAG00000007689" } ] } } ], "crossref": [ { "id": "E1BPE8", "url": "https://alphafold.ebi.ac.uk/entry/E1BPE8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007689", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007689", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR007651", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007651", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013209", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013209", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031703", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031703", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12181", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12181", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12181:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12181:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04571", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04571", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08235", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08235", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16876", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16876", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1483191", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483191", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1483213", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483213", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4419969", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4419969", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75109", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75109", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "27429", "url": "https://www.rhea-db.org/rhea/27429", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LKP8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKP8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKP8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MY10", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MY10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MY10-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MY10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N3Z3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3Z3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N3Z3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3Z3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJB8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJB8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPE8", "url": "https://www.uniprot.org/uniprotkb/E1BPE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPE8-1", "url": "https://www.uniprot.org/uniprotkb/E1BPE8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVVRQPNGSLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMESQLKRNSTDRIRGLDTNTSAQVSPPSETPSSGSLVKKRRKRRRKSQLDSLKRDENMNTSEDEDMFPIEMSSDEEAEPLDSSRTIPDDIPPFQEDVPKESRCPVMTYPQSASYPNSDREWSPSASLVDCRRPPPHLAVAAEGGLSSSCPPQSSHFHASESPSVSRPSTPKSDSELVSKSADRTIQKNNLEMLWLWGELPQATKSSPHKMKESSPLNSRKICDKMHFQAIHSESSDAFSDQSPTLVRASPVQPLLEQNKPQTEIQFVNEDDVEALGAAAPPLPMIEEPKAHSANTAPVAASKTDSPSRKKDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSGLTKPTSDNGARSANQSPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDNREITKDAFLEQAVSYQQFADNPALIDDPNLVVKIGNKYYNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPRKGGRWWFSWRGRNTTIKEESKPEQCLAGKSHSTGEQPSQLGMATRIKHESSSSDEEHAAAKPSSTSHLPLLSSVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVVISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKGATLLTSPARTPSVTSPFGESHRHPLKTRMFILHQPRRFLATPS", "length": 938, "header": "tr|E1BPE8-1|E1BPE8_BOVIN Isoform 1 of phosphatidate phosphatase OS=Bos taurus OX=9913 GN=LPIN1 PE=3 SV=4 CANONICAL=E1BPE8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKP8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKP8/entry", "sequence": { "sequence": "MGGHAPWRVPRSRRRTARIPIMRDPGWIRNVWSSNINAQTMNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVVRQPNGSLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMESQLKRNSTDRIRGLDTNTSAQVSPPSETPSSGSLVKKRRKRRRKSQLDSLKRDENMNTSEDEDMFPIEMSSDEEAEPLDSSRTIPDDIPPFQEDVPKESRCPVMTYPQSASYPNSDREWSPSASPSVSRPSTPKSDSELVSKSADRTIQKNNLEMLWLWGELPQATKSSPHKMKESSPLNSRKICDKMHFQAIHSESSDAFSDQSPTLVRASPVQPLLEQNKPQTEIQFVNEDDVEALGAAAPPLPMIEEPKAHSANTAPVAASKTDSPSRKKDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSGLTKPTSDNGARSANQSPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDNREITKDAFLEQAVSYQQFADNPALIDDPNLVVKIGNKYYNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPRKGGRWWFSWRGRNTTIKEESKPEQCLAGKSHSTGEQPSQLGMATRIKHESSSSDEEHAAAKPSSTSHLPLLSSVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVVISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTFWREPPPPFENQDVHSASA", "length": 935, "header": "tr|A0A3Q1LKP8-1|E1BPE8_BOVIN Computationally mapped isoform of phosphatidate phosphatase OS=Bos taurus OX=9913 GN=LPIN1 PE=3 SV=2 CANONICAL=E1BPE8-1" }, "locus": { "chromosome": "11", "start_pos": 86217344, "end_pos": 86083910, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083005.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083005.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060208.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060208.2" } ] } }, { "isoform_ac": "A0A3Q1MY10-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MY10/entry", "sequence": { "sequence": "MAQTMNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVVRQPNGSLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMESQLKRNSTDRIRGLDTNTSAQVSPPSETPSSGSLVKKRRKRRRKSQLDSLKRDENMNTSEDEDMFPIEMSSDEEAEPLDSSRTIPDDIPPFQEDVPKESRCPVMTYPQSASYPNSDREWSPSASPSVSRPSTPKSDSELVSKSADRTIQKNNLEMLWLWGELPQATKSSPHKMKESSPLNSRKICDKMHFQAIHSESSDAFSDQSPTLVRASPVQPLLEQNKPQTEIQFVNEDDVEALGAAAPPLPMIEEPKAHSANTAPVAASKTDSPSRKKDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSGLTKPTSDNGARSANQSPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDNREITKDAFLEQAVSYQQFADNPALIDDPNLVVKIGNKYYNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPRKGGRWWFSWRGRNTTIKEESKPEQCLAGKSHSTGEQPSQLGMATRIKHESSSSDEEHAAAKPSSTSHLPLLSSVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVVISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTFWREPPPPFENQDVHSASA", "length": 899, "header": "tr|A0A3Q1MY10-1|E1BPE8_BOVIN Computationally mapped isoform of phosphatidate phosphatase OS=Bos taurus OX=9913 GN=LPIN1 PE=3 SV=1 CANONICAL=E1BPE8-1" }, "locus": { "chromosome": "11", "start_pos": 86161948, "end_pos": 86083910, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070606.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070606.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060798.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060798.2" } ] } }, { "isoform_ac": "A0A3Q1N3Z3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3Z3/entry", "sequence": { "sequence": "MEAQTMNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVVRQPNGSLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMESQLKRNSTDRIRGLDTNTSAQVSPPSETPSSGSLVKKRRKRRRKSQLDSLKRDENMNTSEDEDMFPIEMSSDEEAEPLDSSRTIPDDIPPFQEDVPKESRCPVMTYPQSASYPNSDREWSPSASPSVSRPSTPKSDSELVSKSADRTIQKNNLEMLWLWGELPQATKSSPHKMKESSPLNSRKICDKMHFQAIHSESSDAFSDQSPTLVRASPVQPLLEQNKPQTEIQFVNEDDVEALGAAAPPLPMIEEPKAHSANTAPVAASKTDSPSRKKDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSGLTKPTSDNGARSANQSPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDNREITKDAFLEQAVSYQQFADNPALIDDPNLVVKIGNKYYNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPRKGGRWWFSWRGRNTTIKEESKPEQCLAGKSHSTGEQPSQLGMATRIKHESSSSDEEHAAAKPSSTSHLPLLSSVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVVISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTFWREPPPPFENQDVHSASA", "length": 900, "header": "tr|A0A3Q1N3Z3-1|E1BPE8_BOVIN Computationally mapped isoform of phosphatidate phosphatase OS=Bos taurus OX=9913 GN=LPIN1 PE=3 SV=1 CANONICAL=E1BPE8-1" }, "locus": { "chromosome": "11", "start_pos": 86174829, "end_pos": 86083910, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066368.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066368.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064364.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064364.1" } ] } }, { "isoform_ac": "A0AAA9TJB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJB8/entry", "sequence": { "sequence": "MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVVRQPNGSLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMESQLKRNSTDRIRGLDTNTSAQVSPPSETPSSGSLVKKRRKRRRKSQLDSLKRDENMNTSEDEDMFPIEMSSDEEAEPLDSSSPSVSRPSTPKSDSELVSKSADRTIQKNNLEMLWLWGELPQATKSSPHKMKESSPLNSRKICDKMHFQAIHSESSDAFSDQSPTLVRASPVQPLLEQNKPQTEIQFVNEDDVEALGAAAPPLPMIEEPKAHSANTAPVAASKTDSPSRKKDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSGLTKPTSDNGARSANQSPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDNREITKDAFLEQAVSYQQFADNPALIDDPNLVVKIGNKYYNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPRKGGRWWFSWRGRNTTIKEESKPEQCLAGKSHSTGEQPSQLGMATRIKHESSSSDEEHAAAKPSSTSHLPLLSSVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVVISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTFWREPPPPFENQDVHSASA", "length": 853, "header": "tr|A0AAA9TJB8-1|E1BPE8_BOVIN Computationally mapped isoform of phosphatidate phosphatase OS=Bos taurus OX=9913 GN=LPIN1 PE=3 SV=1 CANONICAL=E1BPE8-1" }, "locus": { "chromosome": "11", "start_pos": 86131734, "end_pos": 86083910, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103752.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103752.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098419.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098419.1" } ] } }, { "isoform_ac": "E1BPE8-1", "url": "https://www.uniprot.org/uniprotkb/E1BPE8/entry", "sequence": { "sequence": "MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVVRQPNGSLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMESQLKRNSTDRIRGLDTNTSAQVSPPSETPSSGSLVKKRRKRRRKSQLDSLKRDENMNTSEDEDMFPIEMSSDEEAEPLDSSRTIPDDIPPFQEDVPKESRCPVMTYPQSASYPNSDREWSPSASLVDCRRPPPHLAVAAEGGLSSSCPPQSSHFHASESPSVSRPSTPKSDSELVSKSADRTIQKNNLEMLWLWGELPQATKSSPHKMKESSPLNSRKICDKMHFQAIHSESSDAFSDQSPTLVRASPVQPLLEQNKPQTEIQFVNEDDVEALGAAAPPLPMIEEPKAHSANTAPVAASKTDSPSRKKDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSGLTKPTSDNGARSANQSPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDNREITKDAFLEQAVSYQQFADNPALIDDPNLVVKIGNKYYNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPRKGGRWWFSWRGRNTTIKEESKPEQCLAGKSHSTGEQPSQLGMATRIKHESSSSDEEHAAAKPSSTSHLPLLSSVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVVISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKGATLLTSPARTPSVTSPFGESHRHPLKTRMFILHQPRRFLATPS", "length": 938, "header": "tr|E1BPE8-1|E1BPE8_BOVIN Isoform 1 of phosphatidate phosphatase OS=Bos taurus OX=9913 GN=LPIN1 PE=3 SV=4 CANONICAL=E1BPE8-1" }, "locus": { "chromosome": "11", "start_pos": 86131734, "end_pos": 86083885, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043424.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043424.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040997.5", "url": "https://www.ensembl.org/id/ENSBTAP00000040997.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 936, "start_aa": "Thr", "end_pos": 936, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr936", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1483191", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483191", "resource": "Reactome", "description": "Synthesis of PC" }, { "id": "R-BTA-1483213", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483213", "resource": "Reactome", "description": "Synthesis of PE" }, { "id": "R-BTA-4419969", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4419969", "resource": "Reactome", "description": "Depolymerization of the Nuclear Lamina" }, { "id": "R-BTA-75109", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75109", "resource": "Reactome", "description": "Triglyceride biosynthesis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphatidate phosphatase activity", "id": "GO:0008195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008195", "evidence": [ { "database": "UniProtKB", "id": "E1BPE8", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "E1BPE8", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BPE8", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "E1BPE8", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1BPE8", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BPE8", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "fatty acid catabolic process", "id": "GO:0009062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009062", "evidence": [ { "database": "UniProtKB", "id": "E1BPE8", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ], "pmid": "" }, { "name": "cellular response to insulin stimulus", "id": "GO:0032869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "evidence": [ { "database": "UniProtKB", "id": "E1BPE8", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "E1BPE8", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ], "pmid": "" }, { "name": "triglyceride biosynthetic process", "id": "GO:0019432", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019432", "evidence": [ { "database": "UniProtKB", "id": "E1BPE8", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ], "pmid": "" }, { "name": "phosphatidylethanolamine metabolic process", "id": "GO:0046337", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046337", "evidence": [ { "database": "UniProtKB", "id": "E1BPE8", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 476, "end_pos": 478, "annotation": "n_glycosylation_sequon" }, { "start_pos": 555, "end_pos": 557, "annotation": "n_glycosylation_sequon" }, { "start_pos": 601, "end_pos": 603, "annotation": "n_glycosylation_sequon" }, { "start_pos": 875, "end_pos": 877, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "27429", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BPE8-1", "A0A3Q1M9U2-1", "E1BLQ9-1", "A0AAA9STE8-1", "Q3SZE3-1", "Q2HJ61-1", "F1MH11-1", "F1MXQ6-1" ], "evidence": [ { "id": "27429", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/27429" } ] }, { "id": "R-BTA-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BPE8-1", "A0A3Q1M9U2-1", "E1BLQ9-1" ], "evidence": [ { "id": "R-BTA-1483203", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483203" } ] }, { "id": "R-BTA-4419948", "name": "CTDNEP1:CNEP1R1 dephosphorylates LPIN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nuclear envelope, nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q1RMV9-1", "E1BPE8-1", "A0A3Q1M9U2-1", "E1BLQ9-1" ], "evidence": [ { "id": "R-BTA-4419948", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4419948" } ] }, { "id": "R-BTA-5195402", "name": "CDK1 phosphorylates LPIN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P48734-1", "E1BPE8-1", "A0A3Q1M9U2-1", "E1BLQ9-1" ], "evidence": [ { "id": "R-BTA-5195402", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5195402" } ] }, { "id": "R-BTA-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nuclear envelope, nucleoplasm", "input_participant_list": [ "R-ALL-5221122" ], "output_participant_list": [ "R-ALL-5221124" ], "enzyme_list": [ "E1BPE8-1", "A0A3Q1M9U2-1", "E1BLQ9-1" ], "evidence": [ { "id": "R-BTA-5221130", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5221130" } ] }, { "id": "R-BTA-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-76108" ], "output_participant_list": [], "enzyme_list": [ "E1BPE8-1", "A0A3Q1M9U2-1", "E1BLQ9-1" ], "evidence": [ { "id": "R-BTA-75899", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75899" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5221122", "participant_name": "1,2-diacyl-glycerol 3-phosphate [nuclear envelope]", "crossref": [ { "id": "58608", "database": "ChEBI", "url": "" }, { "id": "25202796", "database": "PubChem Compound", "url": "" }, { "id": "DIACYLGLYCEROL-PYROPHOSPHATE", "database": "AraCyc", "url": "" }, { "id": "C00416", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-5221124", "participant_name": "DAG [nuclear envelope]", "crossref": [ { "id": "17815", "database": "ChEBI", "url": "" }, { "id": "C00165", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-76108", "participant_name": "1,2-daG3P [cytosol]", "crossref": [ { "id": "58608", "database": "ChEBI", "url": "" }, { "id": "25202796", "database": "PubChem Compound", "url": "" }, { "id": "DIACYLGLYCEROL-PYROPHOSPHATE", "database": "AraCyc", "url": "" }, { "id": "C00416", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M9U2", "gene_name": "LPIN2", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "A0A3Q1M9U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9U2" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "A0A3Q1M9U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9U2" } ] } ] }, { "uniprot_ac": "A0AAA9STE8", "gene_name": "PLPP1", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "A0AAA9STE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE8" } ] }, { "ec_number": "3.1.3.106", "activity": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "A0AAA9STE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE8" } ] }, { "ec_number": "3.6.1.75", "activity": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE8" } ] }, { "ec_number": "3.6.1.75", "activity": "", "evidence": [ { "id": "A0AAA9STE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE8" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "A0AAA9STE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE8" } ] }, { "ec_number": "3.1.3.106", "activity": "", "evidence": [ { "id": "A0AAA9STE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE8" } ] } ] }, { "uniprot_ac": "E1BLQ9", "gene_name": "LPIN3", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "E1BLQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ9" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "E1BLQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ9" } ] } ] }, { "uniprot_ac": "E1BPE8", "gene_name": "LPIN1", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "E1BPE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "E1BPE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ] } ] }, { "uniprot_ac": "F1MH11", "gene_name": "PLPP5", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "F1MH11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ] }, { "ec_number": "3.6.1.75", "activity": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + phosphate + H(+).", "evidence": [ { "id": "F1MH11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "F1MH11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ] }, { "ec_number": "3.6.1.75", "activity": "", "evidence": [ { "id": "F1MH11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ] } ] }, { "uniprot_ac": "F1MXQ6", "gene_name": "PLPP4", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "F1MXQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXQ6" } ] }, { "ec_number": "3.6.1.75", "activity": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + phosphate + H(+).", "evidence": [ { "id": "F1MXQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXQ6" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "F1MXQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXQ6" } ] }, { "ec_number": "3.6.1.75", "activity": "", "evidence": [ { "id": "F1MXQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXQ6" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "Q1RMV9", "gene_name": "CTDNEP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMV9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMV9" } ] } ] }, { "uniprot_ac": "Q2HJ61", "gene_name": "PLPP2", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q2HJ61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ61" } ] }, { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "Q2HJ61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ61" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "Q2HJ61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ61" } ] } ] }, { "uniprot_ac": "Q3SZE3", "gene_name": "PLPP3", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q3SZE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE3" } ] }, { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "Q3SZE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE3" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "Q3SZE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPE8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 938, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPE8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPE8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.4", "ec_name": 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"id": "A0A3Q1M2U5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2U5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N078", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N078", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N078-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N078-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6T1", "url": "https://www.uniprot.org/uniprotkb/F1N6T1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6T1-1", "url": "https://www.uniprot.org/uniprotkb/F1N6T1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPPRRKEKYKLPIPLPEGTVLDDMEGKQWVLGKLVGSGGFGLIYLAFPTNKPDKDARHVIKVEYQENGPLFSELKFYQRAAKKDCIKKWIELKKLDYLGIPLFYGSGITEFKGKSYRFMVMERLGIDLQKISDQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYRNPDRVYLADYGLSYRYCPNGNHKQYQENPKKGHNGTIEFTSLDAHKGVALSRRSDLEILGYCLLRWLCGRLPWERNLQDPVAVQAAKTNLLDELPESVLQWAPSGSSCREIAQYLVCAHNLAYDEKPDYQMLKKILNPSGIPLGPLEFYTKGDSLNTHAPDNQKVDSRKAEAKQAYQVQNMLVGKKGHSDRSAESRTPRRKVQEEEKLTGVRNSETVQESTRRRQKYCESQEFQNDVKSSPHESSCIQFPNSFYEPHQDFTNPDMFNKSSSPSWYTNTSTTGMEVTELDSSTGFWLTVSQFTFSEEMKLDIYYYSFTIIFLLILVCLALYFL", "length": 509, "header": "tr|A0A3Q1M2U5-1|A0A3Q1M2U5_BOVIN Isoform 1 of Serine/threonine-protein kinase VRK2 OS=Bos taurus OX=9913 GN=VRK2 PE=3 SV=3 CANONICAL=A0A3Q1M2U5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M2U5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5/entry", "sequence": { "sequence": "MPPRRKEKYKLPIPLPEGTVLDDMEGKQWVLGKLVGSGGFGLIYLAFPTNKPDKDARHVIKVEYQENGPLFSELKFYQRAAKKDCIKKWIELKKLDYLGIPLFYGSGITEFKGKSYRFMVMERLGIDLQKISDQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYRNPDRVYLADYGLSYRYCPNGNHKQYQENPKKGHNGTIEFTSLDAHKGVALSRRSDLEILGYCLLRWLCGRLPWERNLQDPVAVQAAKTNLLDELPESVLQWAPSGSSCREIAQYLVCAHNLAYDEKPDYQMLKKILNPSGIPLGPLEFYTKGDSLNTHAPDNQKVDSRKAEAKQAYQVQNMLVGKKGHSDRSAESRTPRRKVQEEEKLTGVRNSETVQESTRRRQKYCESQEFQNDVKSSPHESSCIQFPNSFYEPHQDFTNPDMFNKSSSPSWYTNTSTTGMEVTELDSSTGFWLTVSQFTFSEEMKLDIYYYSFTIIFLLILVCLALYFL", "length": 509, "header": "tr|A0A3Q1M2U5-1|A0A3Q1M2U5_BOVIN Isoform 1 of Serine/threonine-protein kinase VRK2 OS=Bos taurus OX=9913 GN=VRK2 PE=3 SV=3 CANONICAL=A0A3Q1M2U5-1" }, "locus": { "chromosome": "11", "start_pos": 40797556, "end_pos": 40691592, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080691.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080691.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064356.3", "url": "https://www.ensembl.org/id/ENSBTAP00000064356.3" } ] } }, { "isoform_ac": "A0A3Q1N078-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N078/entry", "sequence": { "sequence": "MPPRRKEKYKLPIPLPEGTVLDDMEGKQWVLGKLVGSGGFGLIYLVKKWIELKKLDYLGIPLFYGSGITEFKGKSYRFMVMERLGIDLQKISDQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYRNPDRVYLADYGLSYRYCPNGNHKQYQENPKKGHNGTIEFTSLDAHKGVALSRRSDLEILGYCLLRWLCGRLPWERNLQDPVAVQAAKTNLLDELPESVLQWAPSGSSCREIAQYLVCAHNLAYDEKPDYQMLKKILNPSGIPLGPLEFYTKGDSLNTHAPDNQKVRRGDPEEIPLVQGKEQRLRFAGAALKRYPTSKVDSRKAEAKQAYQVQNMLVGKKGHSDRSAESRTPRRKVQEEEKLTGVRNSETVQESTRRRQKYCESQEFQNDVKSSPHESSCIQFPNSFYEPHQDFTNPDMFNKSSSPSWYTNTSTTGMEVTELDSSTGFWLTVSQFTFSEEMKLDIYYYSFTIIFLLILVCLALYFL", "length": 502, "header": "tr|A0A3Q1N078-1|A0A3Q1M2U5_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase VRK2 OS=Bos taurus OX=9913 GN=VRK2 PE=3 SV=2 CANONICAL=A0A3Q1M2U5-1" }, "locus": { "chromosome": "11", "start_pos": 40797556, "end_pos": 40691592, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078148.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078148.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062023.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062023.2" } ] } }, { "isoform_ac": "F1N6T1-1", "url": "https://www.uniprot.org/uniprotkb/F1N6T1/entry", "sequence": { "sequence": "MPPRRKEKYKLPIPLPEGTVLDDMEGKQWVLGKLVGSGGFGLIYLAFPTNKPDKDARHVIKVEYQENGPLFSELKFYQRAAKKDCIKKWIELKKLDYLGIPLFYGSGITEFKGKSYRFMVMERLGIDLQKISDQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYRNPDRVYLADYGLSYRYCPNGNHKQYQENPKKGHNGTIEFTSLDAHKGVALSRRSDLEILGYCLLRWLCGRLPWERNLQDPVAVQAAKTNLLDELPESVLQWAPSGSSCREIAQYLVCAHNLAYDEKPDYQMLKKILNPSGIPLGPLEFYTKGDSLNTHAPDNQKVRRGDPEEIPLVQGKEQRLRFAGAALKRYPTSKVDSRKAEAKQAYQVQNMLVGKKGHSDRSAESRTPRRKVQEEEKLTGVRNSETVQESTRRRQKYCESQEFQNDVKSSPHESSCIQFPNSFYEPHQDFTNPDMFNKSSSPSWYTNTSTTGMEVTELDSSTGFWLTVSQFTFSEEMKLDIYYYSFTIIFLLILVCLALYFL", "length": 542, "header": "tr|F1N6T1-1|A0A3Q1M2U5_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase VRK2 OS=Bos taurus OX=9913 GN=VRK2 PE=3 SV=3 CANONICAL=A0A3Q1M2U5-1" }, "locus": { "chromosome": "11", "start_pos": 40797556, "end_pos": 40691592, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047969.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047969.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045115.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045115.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-2980766", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2980766", "resource": "Reactome", "description": "Nuclear Envelope Breakdown" }, { "id": "R-BTA-2995383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2995383", "resource": "Reactome", "description": "Initiation of Nuclear Envelope (NE) Reformation" }, { "id": "R-BTA-9013404", "name": "", "url": 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"https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2U5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2U5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2U5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2U5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ], "pmid": "" }, { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2U5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2U5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2U5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2U5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2U5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2U5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ], "pmid": "" }, { "name": "regulation of interleukin-1-mediated signaling pathway", "id": "GO:2000659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000659", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2U5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ], "pmid": "" }, { "name": "cellular response to oxidative stress", "id": "GO:0034599", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034599", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2U5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ], "pmid": "" }, { "name": "regulation of MAPK cascade", "id": "GO:0043408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043408", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2U5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 444, "end_pos": 446, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", 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"A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "R-BTA-2993898", "name": "VRK1/VRK2 phosphorylate BANF1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "chromosome, nuclear envelope, nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32PI1-1", "A0A3Q1M2U5-1" ], "evidence": [ { "id": "R-BTA-2993898", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2993898" } ] }, { "id": "R-BTA-2995389", "name": "ANKLE2 binds VRK1,(VRK2)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q32PI1-1", "A0A3Q1M2U5-1" ], "evidence": [ { "id": "R-BTA-2995389", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2995389" } ] }, { "id": "R-BTA-9014467", "name": "RHOG binds effectors at the ER membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M2U5-1", "Q3T000-1" ], "evidence": [ { "id": "R-BTA-9014467", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9014467" } ] }, { "id": "R-BTA-9714481", "name": "RAC2 binds effectors at the ER membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M2U5-1", "Q9TU25-1" ], "evidence": [ { "id": "R-BTA-9714481", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9714481" } ] }, { "id": "R-BTA-9714691", "name": "RAC3 binds ER effectors", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M2U5-1", "Q3T000-1" ], "evidence": [ { "id": "R-BTA-9714691", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9714691" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] 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"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + 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"ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": 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O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": 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"ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": 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"uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": 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"ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": 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"uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": 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{ "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T000", "gene_name": "YKT6", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q3T000", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T000" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": 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"Protein" ] }, { "id": "A0AAA9U0E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0E4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP45", "url": "https://www.uniprot.org/uniprotkb/E1BP45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP45-1", "url": "https://www.uniprot.org/uniprotkb/E1BP45-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCMLMVRLIFERFVAKPCAIALNIQANGPQIAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLKRFCESMWKFSYGLYIFTYGIRFLKKTPWLWNTKHCWYNYPYQPLTPDLHYYYILELSFYWSLMFSQFTDIKRKDFAVMFLHHLVAILLITFSYVNNMARVGTLILCLHDSADALLEAAKMANYAKFQKICDLLFVMFAMVFITTRLGVFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLVIQGLNCFWSYLIVKIACKAISKGKVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTGACAMDD", "length": 384, "header": "tr|E1BP45-1|E1BP45_BOVIN Isoform 1 of sphingosine N-acyltransferase OS=Bos taurus OX=9913 GN=CERS6 PE=3 SV=2 CANONICAL=E1BP45-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MJ30-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ30/entry", "sequence": { "sequence": "MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCMLMVRLIFERFVAKPCAIALNIQANGPQIAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLKRFCESMWKFSYGLYIFTYGIRFLKKTPWLWNTKHCWYNYPYQPLTPDLHYYYILELSFYWSLMFSQFTDIKRKDFAVMFLHHLVAILLITFSYVNNMARVGTLILCLHDSADALLEAAKMANYAKFQKICDLLFVMFAMVFITTRLGVFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLVIQGLNCFWSYLIVKIACKAISKGKSGKWNPLHVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTGACAMDD", "length": 392, "header": "tr|A0A3Q1MJ30-1|E1BP45_BOVIN Computationally mapped isoform of sphingosine N-acyltransferase OS=Bos taurus OX=9913 GN=CERS6 PE=3 SV=1 CANONICAL=E1BP45-1" }, "locus": { "chromosome": "2", "start_pos": 27712214, "end_pos": 27359662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080491.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080491.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071330.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071330.1" } ] } }, { "isoform_ac": "A0A3Q1N645-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N645/entry", "sequence": { "sequence": "MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCMLMVRLIFERFVAKPCAIALNIQANGPQIAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLKRFCESMWKFSYGLYIFTYGIRFLKKTPWLWNTKHCWYNYPYQPLTPDLHYYYILELSFYWSLMFSQFTDIKRKDFAVMFLHHLVAILLITFSYVNNMARVGTLILCLHDSADALLEAAKMANYAKFQKICDLLFVMFAMVFITTRLGVFPLWCPRMIEVILSLAQMRRTQNLQERTPILRPPPMGPVVPTGISSLALVPWMINSSKPQVPNKVNCLFLEVFNKLQMQFLS", "length": 360, "header": "tr|A0A3Q1N645-1|E1BP45_BOVIN Computationally mapped isoform of sphingosine N-acyltransferase OS=Bos taurus OX=9913 GN=CERS6 PE=3 SV=1 CANONICAL=E1BP45-1" }, "locus": { "chromosome": "2", "start_pos": 27712214, "end_pos": 27359577, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083511.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083511.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065875.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065875.1" } ] } }, { "isoform_ac": "A0AAA9U0E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0E4/entry", "sequence": { "sequence": "MEQAVVHGISKSWTRLCDYFHFQRFVAKPCAIALNIQANGPQIAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLKRFCESMWKFSYGLYIFTYGIRFLKKTPWLWNTKHCWYNYPYQPLTPDLHYYYILELSFYWSLMFSQFTDIKRKDFAVMFLHHLVAILLITFSYVNNMARVGTLILCLHDSADALLEAAKMANYAKFQKICDLLFVMFAMVFITTRLGVFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLVIQGLNCFWSYLIVKIACKAISKGKVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTGACAMDD", "length": 351, "header": "tr|A0AAA9U0E4-1|E1BP45_BOVIN Computationally mapped isoform of sphingosine N-acyltransferase OS=Bos taurus OX=9913 GN=CERS6 PE=3 SV=1 CANONICAL=E1BP45-1" }, "locus": { "chromosome": "2", "start_pos": 27664533, "end_pos": 27359662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119313.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119313.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103382.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103382.1" } ] } }, { "isoform_ac": "E1BP45-1", "url": "https://www.uniprot.org/uniprotkb/E1BP45/entry", "sequence": { "sequence": "MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCMLMVRLIFERFVAKPCAIALNIQANGPQIAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLKRFCESMWKFSYGLYIFTYGIRFLKKTPWLWNTKHCWYNYPYQPLTPDLHYYYILELSFYWSLMFSQFTDIKRKDFAVMFLHHLVAILLITFSYVNNMARVGTLILCLHDSADALLEAAKMANYAKFQKICDLLFVMFAMVFITTRLGVFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLVIQGLNCFWSYLIVKIACKAISKGKVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTGACAMDD", "length": 384, "header": "tr|E1BP45-1|E1BP45_BOVIN Isoform 1 of sphingosine N-acyltransferase OS=Bos taurus OX=9913 GN=CERS6 PE=3 SV=2 CANONICAL=E1BP45-1" }, "locus": { "chromosome": "2", "start_pos": 27712214, "end_pos": 27359662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061640.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061640.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053442.2", "url": "https://www.ensembl.org/id/ENSBTAP00000053442.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:616901", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616901", "resource": "KEGG Pathway" }, { "id": "R-BTA-1660661", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660661", "resource": "Reactome", "description": "Sphingolipid de novo biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N5K5-1", "protein_name": "Ceramide synthase 6 isoform X1", "gene_name": "Cers6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPVAFCIFMVRLIFERFIAKPCAIALNIQASGPQIAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFIYGVRFLKQTPWLWNTRHCWYNYPYQPLTADLHYYYILELSFYWSLMVSQFTDIKRKDFGIMFLHHLASIFLLSFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAMVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIAWKAVSKGKAGKWNPLHVSKDDRSDIESSSEDEDSEPPGKKPHTSTTTNGTSGTNGYLLTGPCSMDD", "length": 392 }, "evidence": [ { "id": "E1BP45", "url": "https://omabrowser.org/oma/group/E1BP45/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8I6A742-1", "protein_name": "Ceramide synthase 6", "gene_name": "Cers6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFIAKPCAVALNIQANGPQIAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFSYGVRFLKQTPWLWNTRHCWYNYPYQPLTADLHYYYILELSFYWSLMVSQFTDIKRKDFGIMFLHHLATIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLLQGLNCFWSYLIVKIACKTVSKGKVSKDDRSDIESSSDDEDSEPPGKKLHSSTTTNGTSGTNGYLLTGPCSMDD", "length": 384 }, "evidence": [ { "id": "E1BP45", "url": "https://omabrowser.org/oma/group/E1BP45/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V1AA78-1", "protein_name": "Ceramide synthase 6", "gene_name": "CERS6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGILAWFWNERFWLPHNVTWADLQSTEEASFPQAEDLYLAFPLAFCIFMIRLLFERFIAKPCALGLKVQANGPQKAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTKFCESMWRFTFYLYIFTYGVRFLKKTPWLWNTRQCWNGYPYQPLMPDLHYYYIAELSFYWSLMFSQFIDIKRKDFGIMFTHHIVTVTLITFSYVTNLTRVGTLTLCLHDAADVVLEAAKMANYCKCQKLSDLLFLTFAIVFIVSRLGIYPLWILNTTLFELYEALGNFPALWVFNVLLVVLQILHYFWSYLIIKAAYKAISKGKVTKDDRSDIESSSDEEETVPRSKTLHSTITTNGTGGANGTNGYLTGSTCSEEH", "length": 387 }, "evidence": [ { "id": "E1BP45", "url": "https://omabrowser.org/oma/group/E1BP45/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1QPF3-1", "protein_name": "Ceramide synthase 6", "gene_name": "cers6", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAGILAWFWNERFWLPHNVTWADLKNTDDSTFPQAEDLYLACPLAFCMFMIRLVFERFIARPCALGLKIQANGPQKAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRTIQRWFRQRRNQEKPSTLARFCESMWRFSFYLYIFTYGVRFLKKSPWLWNTRECWYNYPYQPLTVDLHYYYILELSFYLSLLFSQFTDIRRKDFVLMFVHHVSTISLLSFSYVNNMARVGTLVLCLHDAADVLLEAAKMANYVKCQRLCPLLFVMFALVFMGSRLALYPVWILNTTVFESWEIIGPYPSWWLFNGLLVLLQALHTFWSYLIVRIACRAISRGKAGKWNPLHVSKDDRSDIESSSDEDELHPPLQKHHTNGTNGAHGTNGYLSSSLCPDEH", "length": 391 }, "evidence": [ { "id": "E1BP45", "url": "https://omabrowser.org/oma/group/E1BP45/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6ZMG9-1", "protein_name": "Ceramide synthase 6", "gene_name": "CERS6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD", "length": 384 }, "evidence": [ { "id": "E1BP45", "url": "https://omabrowser.org/oma/group/E1BP45/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C172-1", "protein_name": "Ceramide synthase 6", "gene_name": "Cers6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFIAKPCAIALNIQANGPQTAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFSYGVRFLKQTPWLWNTRHCWYNYPYQPLTADLHYYYILELSFYWSLMVSQFTDIKRKDFGIMFLHHLATIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLLQGLNCFWSYLIVKIACKTVSKGKVSKDDRSDIESSSDDEDSEPPGKKPHSSTTTNGTSGTNGYLLTGPCSVDD", "length": 384 }, "evidence": [ { "id": "E1BP45", "url": "https://omabrowser.org/oma/group/E1BP45/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BP45", "url": "https://www.uniprot.org/uniprotkb/E1BP45" } ], "pmid": "" }, { "name": "sphingosine N-acyltransferase activity", "id": "GO:0050291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050291", "evidence": [ { "database": "UniProtKB", "id": "E1BP45", "url": "https://www.uniprot.org/uniprotkb/E1BP45" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BP45", "url": "https://www.uniprot.org/uniprotkb/E1BP45" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1BP45", "url": "https://www.uniprot.org/uniprotkb/E1BP45" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1BP45", "url": "https://www.uniprot.org/uniprotkb/E1BP45" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ceramide biosynthetic process", "id": "GO:0046513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046513", "evidence": [ { "database": "UniProtKB", "id": "E1BP45", "url": "https://www.uniprot.org/uniprotkb/E1BP45" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" }, { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" }, { "start_pos": 366, "end_pos": 368, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23768", "name": "", "equation": "sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBF8-1", "Q5E9R6-1", "A0AAA9TDQ3-1", "E1BP45-1", "A0A3Q1MVP2-1" ], "evidence": [ { "id": "23768", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23768" } ] }, { "id": "33351", "name": "", "equation": "hexacosanoyl-CoA + sphinganine = N-hexacosanoylsphinganine + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBF8-1", "Q5E9R6-1", "A0AAA9TDQ3-1", "E1BP45-1", "A0A3Q1MVP2-1" ], "evidence": [ { "id": "33351", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33351" } ] }, { "id": "33591", "name": "", "equation": "tetracosanoyl-CoA + sphinganine = N-tetracosanoylsphinganine + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBF8-1", "Q5E9R6-1", "A0AAA9TDQ3-1", "E1BP45-1", "A0A3Q1MVP2-1" ], "evidence": [ { "id": "33591", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33591" } ] }, { "id": "36535", "name": "", "equation": "docosanoyl-CoA + sphinganine = N-docosanoylsphinganine + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBF8-1", "Q5E9R6-1", "A0AAA9TDQ3-1", "E1BP45-1", "A0A3Q1MVP2-1" ], "evidence": [ { "id": "36535", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36535" } ] }, { "id": "36547", "name": "", "equation": "sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BP45-1", "A0A3Q1MVP2-1", "Q3ZBF8-1", "A0AAA9TDQ3-1", "Q5E9R6-1" ], "evidence": [ { "id": "36547", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36547" } ] }, { "id": "36555", "name": "", "equation": "eicosanoyl-CoA + sphinganine = N-eicosanoylsphinganine + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBF8-1", "Q5E9R6-1", "A0AAA9TDQ3-1", "E1BP45-1", "A0A3Q1MVP2-1" ], "evidence": [ { "id": "36555", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36555" } ] }, { "id": "36691", "name": "", "equation": "sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBF8-1", "Q5E9R6-1", "A0AAA9TDQ3-1", "E1BP45-1", "A0A3Q1MVP2-1" ], "evidence": [ { "id": "36691", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36691" } ] }, { "id": "R-BTA-428185", "name": "Ceramide synthases transfer acyl-CoA onto sphingoid", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-5279323" ], "output_participant_list": [], "enzyme_list": [ "Q3ZBF8-1", "Q5E9R6-1", "A0A3Q1MVP2-1", "E1BP45-1" ], "evidence": [ { "id": "R-BTA-428185", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-428185" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5279323", "participant_name": "sphingoid base [cytoplasm]", "crossref": [ { "id": "35785", "database": "ChEBI", "url": "" }, { "id": "Sphingoids", "database": "AraCyc", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MVP2", "gene_name": "CERS5", "activity": [ { "ec_number": "2.3.1.24", "activity": "a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+).", "evidence": [ { "id": "A0A3Q1MVP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVP2" } ] }, { "ec_number": 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"end_pos": 20452687, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087129.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087129.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066569.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066569.2" } ] } }, { "isoform_ac": "A0A3Q1NDA1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDA1/entry", "sequence": { "sequence": "MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKAEVKQKWASRLLAKLRKDIRPECREDFVLAITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRAGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGMRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPLNGSGQLKMSSHCLSAQMLAPPPPGLPRLALPPATKPTSEGGSSSPTSPSYSTPGTSPANRSFVGLGPRDPAGIYQAQSWYLG", "length": 497, "header": "tr|A0A3Q1NDA1-1|A0A3Q1M3P9_BOVIN Computationally mapped isoform of Nuclear factor 1 OS=Bos taurus OX=9913 GN=NFIC PE=3 SV=2 CANONICAL=A0A3Q1M3P9-1" }, "locus": { "chromosome": "7", "start_pos": 20516033, "end_pos": 20448456, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070787.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070787.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069458.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069458.2" } ] } }, { "isoform_ac": "A0AAA9TBG7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBG7/entry", "sequence": { "sequence": "MEVPGPLVSSKPGETSVKWQLCYDMTAKMWWMDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKAEVKQKWASRLLAKLRKDIRPECREDFVLAITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRAGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGMRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPLNGSGQLKMSSHCLSAQMLAPPPPGLPRLALPPATKPTSEGGSSSPTSPSYSTPGTSPANRSFVGLGPRDPAGIYQAQSWYLG", "length": 528, "header": "tr|A0AAA9TBG7-1|A0A3Q1M3P9_BOVIN Computationally mapped isoform of Nuclear factor 1 OS=Bos taurus OX=9913 GN=NFIC PE=3 SV=1 CANONICAL=A0A3Q1M3P9-1" }, "locus": { "chromosome": "7", "start_pos": 20548044, "end_pos": 20448456, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115463.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115463.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094020.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094020.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 476, "start_aa": "Thr", "end_pos": 476, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr476", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5Y8C6-1", "protein_name": "Nuclear factor 1", "gene_name": "Nfic", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHERARARGRRTRRWGCRRGHRSSGSLGLQPRTGRSAGWGGRVGGGRAGGGSAGGAGSSPRASPRASPRASPPAVASPHSAMDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKAEVKQKWASRLLAKLRKDIRPECREDFVLAVTGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAACAHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSSSPRTGVGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASAGMRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPNSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPATPILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPATQQPGPPALRPARPLQTVPLWD", "length": 511 }, "evidence": [ { "id": "A0A3Q1M3P9", "url": "https://omabrowser.org/oma/group/A0A3Q1M3P9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P08651-1", "protein_name": "Nuclear factor 1 C-type", "gene_name": "NFIC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQPGPLNGSGQLKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPDTSPANRSFVGLGPRDPAGIYQAQSWYLG", "length": 508 }, "evidence": [ { "id": "A0A3Q1M3P9", "url": "https://omabrowser.org/oma/group/A0A3Q1M3P9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P70255-1", "protein_name": "Nuclear factor 1 C-type", "gene_name": "Nfic", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKAEVKQKWASRLLAKLRKDIRPECREDFVLAVTGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAACAHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQSSSPRTGVGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASAGMRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPNSPTSSSRNWTEDIEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPTSALHFPATPILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPATQQPGPPALRPTRPLQTVPLWD", "length": 439 }, "evidence": [ { "id": "A0A3Q1M3P9", "url": "https://omabrowser.org/oma/group/A0A3Q1M3P9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3P9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3P9" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3P9" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3P9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3P9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3P9" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3P9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3P9" } ], "pmid": "" }, { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3P9" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3P9" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3P9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 312, "end_pos": 314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 425, "end_pos": 427, "annotation": "n_glycosylation_sequon" }, { "start_pos": 483, "end_pos": 485, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M3P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3P9" }, { "id": "PS51080", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51080" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CTF/NF-I", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 195, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 476 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], 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}, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BP84-1", "uniprot_ac": "E1BP84", "uniprot_id": "E1BP84_BOVIN", "mass": { "chemical_mass": 110508.0, "monoisotopic_mass": 110508.0 }, "refseq": {}, "gene_names": [ { "name": 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Associates with the nucleosome remodeling and histone deacetylase (NuRD) complex, which promotes transcriptional repression by histone deacetylation and nucleosome remodeling. Sequence-specific DNA-binding protein that recognizes repetitive and non-consecutive TTC sequences in pericentric repeat and initiate heterochromatin formation through interaction with SUV39H1/2 methyltransferases which catalyze histone H3K9 methylation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1N7E9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7E9#function" }, { "database": "UniProtKB", "id": "ARBA00094431", "url": "https://www.uniprot.org/uniprotkb/ARBA00094431#function" }, { "database": "UniProtKB", "id": "A0AAA9TXQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXQ1#function" }, { "database": "UniProtKB", "id": "E1BP84", "url": "https://www.uniprot.org/uniprotkb/E1BP84#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP84", "url": "https://www.uniprot.org/uniprotkb/E1BP84" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF512B", "url": "https://www.uniprot.org/uniprotkb/E1BP84", "locus": { "chromosome": "13", "start_pos": 53888496, "end_pos": 53879589, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011646", "url": "https://www.ensembl.org/id/ENSBTAG00000011646" } ] } } ], "crossref": [ { "id": "E1BP84", "url": "https://alphafold.ebi.ac.uk/entry/E1BP84", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011646", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011646", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048408", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048408", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052274", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052274", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR22979", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22979", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22979:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22979:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21276", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21276", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9013424", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013424", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1N7E9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7E9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7E9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7E9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP84", "url": "https://www.uniprot.org/uniprotkb/E1BP84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP84-1", "url": "https://www.uniprot.org/uniprotkb/E1BP84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N139", "url": "https://www.uniprot.org/uniprotkb/G3N139", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N139-1", "url": "https://www.uniprot.org/uniprotkb/G3N139-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQFTPVPENRRRRRHWPLCSDGPAHAGDGQAAGLGNGRTGPLPRPVSPVAEQQQEYRESSPPPPNSKTVKGGRGGSAHVRSAARSLRRPDPAPLAPRPGPARPRPAPGPGLLGAAEMTDPFCVGGGRRVPGSSRSGPGKDGSRNEVRLPVLHEPPKLGLPVVRAGQTVPSQAALCFDLESPAGDRTEGKKKGRPKAENQALRDIPLSLMNQWKDEFKAHSRVKCPNAGCWLEFPSIYGLKYHYQRCQGGAISERLTFPCPFCEAAFTSKTQLEKHRIWNHMDRPLPAPKPGPVSRPVTVSRPVGVSKPIGVSKPVTISKPIGISKPVTVSRPVPVSKPVTVSRPVPVTKPVTISRPVPVTKAVPVTRPVQVNKPIPVTKSVPIAKPVTVNKPVPVTKPVTINKSVPMTKLVTVTKPVPVAKPVTVSRPIVVSKPVTVSRPIAISRHTPPCKVVLLTKSENKAPRAAGRSSGKKRTADGLDTCPIPPKHARPENGEYGPATPEQSSAFQLSTDPSSSPLSLGSRPSGGKEVPRAPGPGSPPEEGAERVKHRRKQKTPKKFTGEQPSISGTFGLKGLAKAEDKARIHRAKKQEGPGPEDTRKKGPAPTSAVSKEVPAPMTHPAPGGPEEQWQRAIHERGEAVCPTCNVVTRKTLVGLKKHMEVCQKLQDALKCQHCRKQFKSKAGLNYHTMAEHSTKPSDAEASEGSEQEERERLRKVLKQMGRLRCPQEGCGAAFSSLMGYQYHQRRCGKPPCEVETPSFPCTHCGKPYRSKAGHDYHVRSEHTAPPPEEPSDKASEAEDPLGVERTPSGRIRRTSAQVAVFHLQEIAEDELARDWTKRRMKDDLVPETARLNYTRPGLPVLNPELLEAWKNEVKEKGHVNCPNDCCEAIYSSVSGLKAHLASCSKGDHLVGKYCCLLCPKEFSSESGVKYHILKTHAENWFRTSADPPPRHKGVDSPVPRKEKSPASGKKRGRKPKERPSEEPAPGTPPHQDDWPPAGRDKGARGSTGRKVGAGKAPEK", "length": 1020, "header": "tr|E1BP84-1|E1BP84_BOVIN Isoform 1 of Zinc finger protein 512B OS=Bos taurus OX=9913 GN=ZNF512B PE=3 SV=4 CANONICAL=E1BP84-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N7E9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7E9/entry", "sequence": { "sequence": "MAEQAPSPDPSLPSPSSSRNTARVRPLPPTVKLSKVGGAGARMCAARRAACAARTLRPSPRAPARPGPGLPPAPACWAPQASSGPRPPNSEFSTQAGGGLERPGSAEMTDPFCVGGGRRVPGSSRSGPGKDGSRNEVRLPVLHEPPKLGLPVVRAGQTVPSQAALCFDLESPAGDRTEGKKKGRPKAENQALRDIPLSLMNQWKDEFKAHSRVKCPNAGCWLEFPSIYGLKYHYQRCQGGAISERLTFPCPFCEAAFTSKTQLEKHRIWNHMDRPLPAPKPGPVSRPVTVSRPVGVSKPIGVSKPVTISKPIGISKPVTVSRPVPVSKPVTVSRPVPVTKPVTISRPVPVTKAVPVTRPVQVNKPIPVTKSVPIAKPVTVNKPVPVTKPVTINKSVPMTKLVTVTKPVPVAKPVTVSRPIVVSKPVTVSRPIAISRHTPPCKVVLLTKSENKAPRAAGRSSGKKRTADGLDTCPIPPKHARPENGEYGPATPEQSSAFQLSTDPSSSPLSLGSRPSGGKEVPRAPGPGSPPEEGAERVKHRRKQKTPKKFTGEQPSISGTFGLKGLAKAEDKARIHRAKKQEGPGPEDTRKKGPAPTSAVSKEVPAPMTHPAPGGPEEQWQRAIHERGEAVCPTCNVVTRKTLVGLKKHMEVCQKLQDALKCQHCRKQFKSKAGLNYHTMAEHSTKPSDAEASEGSEQEERERLRKVLKQMGRLRCPQEGCGAAFSSLMGYQYHQRRCGKPPCEVETPSFPCTHCGKPYRSKAGHDYHVRSEHTAPPPEEPSDKASEAEDPLGVERTPSGRIRRTSAQVAVFHLQEIAEDELARDWTKRRMKDDLVPETARLNYTRPGLPVLNPELLEAWKNEVKEKGHVNCPNDCCEAIYSSVSGLKAHLASCSKGDHLVGKYCCLLCPKEFSSESGVKYHILKTHAENWFRTSADPPPRHKGVDSPVPRKEKSPASGKKRGRKPKERPSEEPAPGTPPHQDDWPPAGRDKGARGSTGRKVGAGKAPEK", "length": 1010, "header": "tr|A0A3Q1N7E9-1|E1BP84_BOVIN Computationally mapped isoform of Zinc finger protein 512B OS=Bos taurus OX=9913 GN=ZNF512B PE=3 SV=2 CANONICAL=E1BP84-1" }, "locus": { "chromosome": "13", "start_pos": 53887492, "end_pos": 53879878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077131.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077131.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066589.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066589.2" } ] } }, { "isoform_ac": "A0AAA9TXQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXQ1/entry", "sequence": { "sequence": "MAAGTRSDFLCSMSPQSWLSLMNQWKDEFKAHSRVKCPNAGCWLEFPSIYGLKYHYQRCQGGAISERLTFPCPFCEAAFTSKTQLEKHRIWNHMDRPLPAPKPGPVSRPVTVSRPVGVSKPIGVSKPVTISKPIGISKPVTVSRPVPVSKPVTVSRPVPVTKPVTISRPVPVTKAVPVTRPVQVNKPIPVTKSVPIAKPVTVNKPVPVTKPVTINKSVPMTKLVTVTKPVPVAKPVTVSRPIVVSKPVTVSRPIAISRHTPPCKVVLLTKSENKAPRAAGRSSGKKRTADGLDTCPIPPKHARPENGEYGPATPEQSSAFQLSTDPSSSPLSLGSRPSGGKEVPRAPGPGSPPEEGAERVKHRRKQKTPKKFTGEQPSISGTFGLKGLAKAEDKARIHRAKKQEGPGPEDTRKKGPAPTSAVSKEVPAPMTHPAPGGPEEQWQRAIHERGEAVCPTCNVVTRKTLVGLKKHMEVCQKLQDALKCQHCRKQFKSKAGLNYHTMAEHSTKPSDAEASEGSEQEERERLRKVLKQMGRLRCPQEGCGAAFSSLMGYQYHQRRCGKPPCEVETPSFPCTHCGKPYRSKAGHDYHVRSEHTAPPPEEPSDKASEAEDPLGVERTPSGRIRRTSAQVAVFHLQEIAEDELARDWTKRRMKDDLVPETARLNYTRPGLPVLNPELLEAWKNEVKEKGHVNCPNDCCEAIYSSVSGLKAHLASCSKGDHLVGKYCCLLCPKEFSSESGVKYHILKTHAENWFRTSADPPPRHKGVDSPVPRKEKSPASGKKRGRKPKERPSEEPAPGTPPHQDDWPPAGRDKGARGSTGRKVGAGKAPEK", "length": 832, "header": "tr|A0AAA9TXQ1-1|E1BP84_BOVIN Computationally mapped isoform of Zinc finger protein 512B OS=Bos taurus OX=9913 GN=ZNF512B PE=3 SV=1 CANONICAL=E1BP84-1" }, "locus": { "chromosome": "13", "start_pos": 53887492, "end_pos": 53882081, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111876.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111876.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101429.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101429.1" } ] } }, { "isoform_ac": "E1BP84-1", "url": "https://www.uniprot.org/uniprotkb/E1BP84/entry", "sequence": { "sequence": "MPQFTPVPENRRRRRHWPLCSDGPAHAGDGQAAGLGNGRTGPLPRPVSPVAEQQQEYRESSPPPPNSKTVKGGRGGSAHVRSAARSLRRPDPAPLAPRPGPARPRPAPGPGLLGAAEMTDPFCVGGGRRVPGSSRSGPGKDGSRNEVRLPVLHEPPKLGLPVVRAGQTVPSQAALCFDLESPAGDRTEGKKKGRPKAENQALRDIPLSLMNQWKDEFKAHSRVKCPNAGCWLEFPSIYGLKYHYQRCQGGAISERLTFPCPFCEAAFTSKTQLEKHRIWNHMDRPLPAPKPGPVSRPVTVSRPVGVSKPIGVSKPVTISKPIGISKPVTVSRPVPVSKPVTVSRPVPVTKPVTISRPVPVTKAVPVTRPVQVNKPIPVTKSVPIAKPVTVNKPVPVTKPVTINKSVPMTKLVTVTKPVPVAKPVTVSRPIVVSKPVTVSRPIAISRHTPPCKVVLLTKSENKAPRAAGRSSGKKRTADGLDTCPIPPKHARPENGEYGPATPEQSSAFQLSTDPSSSPLSLGSRPSGGKEVPRAPGPGSPPEEGAERVKHRRKQKTPKKFTGEQPSISGTFGLKGLAKAEDKARIHRAKKQEGPGPEDTRKKGPAPTSAVSKEVPAPMTHPAPGGPEEQWQRAIHERGEAVCPTCNVVTRKTLVGLKKHMEVCQKLQDALKCQHCRKQFKSKAGLNYHTMAEHSTKPSDAEASEGSEQEERERLRKVLKQMGRLRCPQEGCGAAFSSLMGYQYHQRRCGKPPCEVETPSFPCTHCGKPYRSKAGHDYHVRSEHTAPPPEEPSDKASEAEDPLGVERTPSGRIRRTSAQVAVFHLQEIAEDELARDWTKRRMKDDLVPETARLNYTRPGLPVLNPELLEAWKNEVKEKGHVNCPNDCCEAIYSSVSGLKAHLASCSKGDHLVGKYCCLLCPKEFSSESGVKYHILKTHAENWFRTSADPPPRHKGVDSPVPRKEKSPASGKKRGRKPKERPSEEPAPGTPPHQDDWPPAGRDKGARGSTGRKVGAGKAPEK", "length": 1020, "header": "tr|E1BP84-1|E1BP84_BOVIN Isoform 1 of Zinc finger protein 512B OS=Bos taurus OX=9913 GN=ZNF512B PE=3 SV=4 CANONICAL=E1BP84-1" }, "locus": { "chromosome": "13", "start_pos": 53887492, "end_pos": 53879769, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039336.7", "url": "https://www.ensembl.org/id/ENSBTAT00000039336.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039132.6", "url": "https://www.ensembl.org/id/ENSBTAP00000039132.6" } ] } }, { "isoform_ac": "G3N139-1", "url": "https://www.uniprot.org/uniprotkb/G3N139/entry", "sequence": { "sequence": "MTDPFCVGGGRRVPGSSRSGPGKDGSRNEVRLPVLHEPPKLGLPVVRAGQTVPSQAALCFDLESPAGDRTEGKKKGRPKAENQALRDIPLSLMNQWKDEFKAHSRVKCPNAGCWLEFPSIYGLKYHYQRCQGGAISERLTFPCPFCEAAFTSKTQLEKHRIWNHMDRPLPAPKPGPVSRPVTVSRPVGVSKPIGVSKPVTISKPIGISKPVTVSRPVPVSKPVTVSRPVPVTKPVTISRPVPVTKAVPVTRPVQVNKPIPVTKSVPIAKPVTVNKPVPVTKPVTINKSVPMTKLVTVTKPVPVAKPVTVSRPIVVSKPVTVSRPIAISRHTPPCKVVLLTKSENKAPRAAGRSSGKKRTADGLDTCPIPPKHARPENGEYGPATPEQSSAFQLSTDPSSSPLSLGSRPSGGKEVPRAPGPGSPPEEGAERVKHRRKQKTPKKFTGEQPSISGTFGLKGLAKAEDKARIHRAKKQEGPGPEDTRKKGPAPTSAVSKEVPAPMTHPAPGGPEEQWQRAIHERGEAVCPTCNVVTRKTLVGLKKHMEVCQKLQDALKCQHCRKQFKSKAGLNYHTMAEHSTKPSDAEASEGSEQEERERLRKVLKQMGRLRCPQEGCGAAFSSLMGYQYHQRRCGKPPCEVETPSFPCTHCGKPYRSKAGHDYHVRSEHTAPPPEEPSDKASEAEDPLGVERTPSGRIRRTSAQVAVFHLQEIAEDELARDWTKRRMKDDLVPETARLNYTRPGLPVLNPELLEAWKNEVKEKGHVNCPNDGDHLVGKYCCLLCPKEFSSESGVKYHILKTHAENWFRTSADPPPRHKGVDSPVPRKEKSPASGKKRGRKPKERPSEEPAPGTPPHQDDWPPAGRDKGARGSTGRKVGAGKAPEK", "length": 882, "header": "tr|G3N139-1|E1BP84_BOVIN Computationally mapped isoform of Zinc finger protein 512B OS=Bos taurus OX=9913 GN=ZNF512B PE=3 SV=3 CANONICAL=E1BP84-1" }, "locus": { "chromosome": "13", "start_pos": 53887492, "end_pos": 53882011, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065675.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065675.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055562.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055562.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 607, "start_aa": "Thr", "end_pos": 607, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr607", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 988, "start_aa": "Thr", "end_pos": 988, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr988", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-9013424", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013424", "resource": "Reactome", "description": "RHOV GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BP84", "url": "https://www.uniprot.org/uniprotkb/E1BP84" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BP84", "url": "https://www.uniprot.org/uniprotkb/E1BP84" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "E1BP84", "url": "https://www.uniprot.org/uniprotkb/E1BP84" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "E1BP84", "url": "https://www.uniprot.org/uniprotkb/E1BP84" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BP84", "url": "https://www.uniprot.org/uniprotkb/E1BP84" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BP84", "url": "https://www.uniprot.org/uniprotkb/E1BP84" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BP84", "url": "https://www.uniprot.org/uniprotkb/E1BP84" } ], "pmid": "" }, { "name": "negative regulation of miRNA transcription", "id": "GO:1902894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902894", "evidence": [ { "database": "UniProtKB", "id": "E1BP84", "url": "https://www.uniprot.org/uniprotkb/E1BP84" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" }, { "start_pos": 853, "end_pos": 855, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BP84-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1020, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BP84-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BP84" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BP84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP84" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 258, "end_pos": 285, "start_aa": "Phe", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 607, 988 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 403, "end_pos": 405 }, { "start_pos": 853, "end_pos": 855 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"MHPGLWLLLVTLCLTEELAGAGEKKPYGKPCGGQDCSGGCKCSPEKGARGRPGPIGIQGPTGPQGLPGPSGLSGLKGERGSPGPLGPYGPKGDKGPMGVPGFLGINGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYSGLPGPPGLPGQKGSKGEPVLAQGSFKGMKGESGLPGLDGITGPQGAPGSPGAVGPRGPPGLQGPPGPPGFPGPDGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPQGFPGVSGPPGLPGFGIAGEKGEKGIPGLPGPRGPMGLEGVQGPPGSQGRKGSSGFPGLNGFPGIKGEKGGIGLPGPDIFIDTDGAVISGYPGDPGMPGLPGLKGDEGIQGLPGPPGAPGLPALPGGPGALGPQGALGLKGERGNTGRTTTGAAGLPGRDGLPGLPGLPGPPGAASETGTLQSTEPGSPGLRGERGPKGHPGLKGIKGDPGFCACDGGVPNMGPPGEPGLPGPPGLLGLPGLKGTKGDPGSGGAQGPSGDPGVFGPRGPTGPKGKKGDPTLSTRSGMPGEQGDPGPQGLPGETGAPGKDGIPGLPGLPGLLGDGAQGFPGEKGLPGLPGEKGHTGPTGPPGIGLPGAPGPRGLPGDKGVDGLPGQPGPRGVPGITLPCIIPGPYGPSGLPGAPGFPGPKGARGLPGAPGQPGLRGNKGDPGSPGLVHLPELPGFPGPHGEKGLPGFPGLPGKDGLPGKVGSPGLPGPKGAPGDILGAENGAPGEQGLQGLPGDRGFPGDSGLPGLKGLLGKSGLLGPKGERGSPGIPGRVGQPGPPGPSGLFGIKGKPGLRGPPGFPGISGYPGKKGPRGEIGLPASAGKRGLPGLKGLPGLPGPIGFLGNSGLPGATGLPGLPGLKGEKGSVGLTGFPGIPGLPGIPGASGLKGIPGSTGRVGPSGWAGSPGEKGDRGDPGPFGIPSHRPPMLNLRFKGDKGSQGSPGAIGFPGPRGDKGEAGHPGPPGLPGAPGFPSLIKGLSGRPGPPGSTGLRGLPGLKGYPGIAGFQGIPGESGSQGLSGVPGLPGASGLPGLKGDQGQTLGISGSPGPKGQPGESGFKGVKGKDGPVGDVGFPGNKGEDGKVGISGDVGLPGSLGLPGVAGMRGNPGLPGSPGHPGATGPLGPPGLIGTKGFPGLPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGLPGPKGEKGSPGIGIGAPGKPGIRGPKGSQGFPGLQGAAGLPGALGLSLPSVIEGQPGDPGRPGLDGERGRPGPPGPPGPPGPASDQGDPGDPGFPGIPGPQGPKGDQGIPGFSGLPGELGLKGMRGEPGFMGTPGKVGPPGDPGLPGMKGKAGPRGLSGPRGAPGHTPIAEAIQAPPGPMGLPGIDGIPGLMGDPGVQGPVGLQGSKGLPGIPGKDGASGLPGPPGALGDPGLPGLQGPPGFEGAPGKPGPFGRAGVPGQSLRVGYTLVKHSQSEQVPLCPSGMSQLWVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVGQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGEEPVSETLKAGQLHTRVSRCQVCMKSV", "length": 1688, "header": "tr|A0A3Q1M1R0-1|A0A3Q1M1R0_BOVIN Isoform 1 of Collagen type IV alpha 6 chain OS=Bos taurus OX=9913 GN=COL4A6 PE=4 SV=2 CANONICAL=A0A3Q1M1R0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1R0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1R0/entry", "sequence": { "sequence": "MHPGLWLLLVTLCLTEELAGAGEKKPYGKPCGGQDCSGGCKCSPEKGARGRPGPIGIQGPTGPQGLPGPSGLSGLKGERGSPGPLGPYGPKGDKGPMGVPGFLGINGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYSGLPGPPGLPGQKGSKGEPVLAQGSFKGMKGESGLPGLDGITGPQGAPGSPGAVGPRGPPGLQGPPGPPGFPGPDGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPQGFPGVSGPPGLPGFGIAGEKGEKGIPGLPGPRGPMGLEGVQGPPGSQGRKGSSGFPGLNGFPGIKGEKGGIGLPGPDIFIDTDGAVISGYPGDPGMPGLPGLKGDEGIQGLPGPPGAPGLPALPGGPGALGPQGALGLKGERGNTGRTTTGAAGLPGRDGLPGLPGLPGPPGAASETGTLQSTEPGSPGLRGERGPKGHPGLKGIKGDPGFCACDGGVPNMGPPGEPGLPGPPGLLGLPGLKGTKGDPGSGGAQGPSGDPGVFGPRGPTGPKGKKGDPTLSTRSGMPGEQGDPGPQGLPGETGAPGKDGIPGLPGLPGLLGDGAQGFPGEKGLPGLPGEKGHTGPTGPPGIGLPGAPGPRGLPGDKGVDGLPGQPGPRGVPGITLPCIIPGPYGPSGLPGAPGFPGPKGARGLPGAPGQPGLRGNKGDPGSPGLVHLPELPGFPGPHGEKGLPGFPGLPGKDGLPGKVGSPGLPGPKGAPGDILGAENGAPGEQGLQGLPGDRGFPGDSGLPGLKGLLGKSGLLGPKGERGSPGIPGRVGQPGPPGPSGLFGIKGKPGLRGPPGFPGISGYPGKKGPRGEIGLPASAGKRGLPGLKGLPGLPGPIGFLGNSGLPGATGLPGLPGLKGEKGSVGLTGFPGIPGLPGIPGASGLKGIPGSTGRVGPSGWAGSPGEKGDRGDPGPFGIPSHRPPMLNLRFKGDKGSQGSPGAIGFPGPRGDKGEAGHPGPPGLPGAPGFPSLIKGLSGRPGPPGSTGLRGLPGLKGYPGIAGFQGIPGESGSQGLSGVPGLPGASGLPGLKGDQGQTLGISGSPGPKGQPGESGFKGVKGKDGPVGDVGFPGNKGEDGKVGISGDVGLPGSLGLPGVAGMRGNPGLPGSPGHPGATGPLGPPGLIGTKGFPGLPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGLPGPKGEKGSPGIGIGAPGKPGIRGPKGSQGFPGLQGAAGLPGALGLSLPSVIEGQPGDPGRPGLDGERGRPGPPGPPGPPGPASDQGDPGDPGFPGIPGPQGPKGDQGIPGFSGLPGELGLKGMRGEPGFMGTPGKVGPPGDPGLPGMKGKAGPRGLSGPRGAPGHTPIAEAIQAPPGPMGLPGIDGIPGLMGDPGVQGPVGLQGSKGLPGIPGKDGASGLPGPPGALGDPGLPGLQGPPGFEGAPGKPGPFGRAGVPGQSLRVGYTLVKHSQSEQVPLCPSGMSQLWVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVGQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGEEPVSETLKAGQLHTRVSRCQVCMKSV", "length": 1688, "header": "tr|A0A3Q1M1R0-1|A0A3Q1M1R0_BOVIN Isoform 1 of Collagen type IV alpha 6 chain OS=Bos taurus OX=9913 GN=COL4A6 PE=4 SV=2 CANONICAL=A0A3Q1M1R0-1" }, "locus": { "chromosome": "X", "start_pos": 57139761, "end_pos": 56803360, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074542.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074542.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063676.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063676.2" } ] } }, { "isoform_ac": "A0A3Q1M906-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M906/entry", "sequence": { "sequence": "MHPGLWLLLVTLCLTEELAGAGEKKPYGKPCGGQDCSGGCKCSPEKGARGRPGPIGIQGPTGPQGLPGPSGLSGLKGERGSPGPLGPYGPKGDKGPMGVPGFLGINGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYSGLPGPPGLPGQKGSKGEPVLAQGSFKGMKGESGLPGLDGITGPQGAPGSPGAVGPRGPPGLQGPPGPPGFPGPDGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPQGFPGVSGPPGLPGFGIAGEKGEKGIPGLPGPRGPMGLEGVQGPPGSQGRKGSSGFPGLNGFPGIKGEKGGIGLPGPDIFIDTDGAVISGYPGDPGMPGLPGLKGDEGIQGLPGPPGAPGLPALPGGPGALGPQGALGLKGERGNTGRTTTGAAGLPGRDGLPGLPGLPGPPGAASETGTLQSTEPGSPGLRGERGPKGHPGLKGIKGDPGFCACDGGVPNMGPPGEPGLPGPPGLLGLPGLKGTKGDPGSGGAQGPSGDPGVFGPRGPTGPKGKKGDPTLSTRSGMPGEQGDPGPQGLPGETGAPGKDGIPGLPGLPGLLGDGAQGFPGEKGLPGLPGEKGHTGPTGPPGIGLPGAPGPRGLPGDKGVDGLPGQPGPRGVPGITLPCIIPGPYGPSGLPGAPGFPGPKGARGLPGAPGQPGLRGNKGDPGSPGLVHLPELPGFPGPHGEKGLPGFPGLPGKDGLPGKVGSPGLPGPKGAPGDILGAENGAPGEQGLQGLPGDRGFPGDSGLPGLKGLLGKSGLLGPKGERGSPGIPGRVGQPGPPGPSGLFGIKGKPGLRGPPGFPGISGYPGKKGPRGEIGLPASAGKRGLPGLKGLPGLPGPIGFLGNSGLPGATGLPGLPGLKGEKGSVGLTGFPGIPGLPGIPGASGLKGIPGSTGRVGPSGWAGSPGEKGDRGDPGPFGIPSHRPPMLNLRFKGDKGSQGSPGAIGFPGPRGDKGEAGHPGPPGLPGAPGFPSLIKGLSGRPGPPGSTGLRGLPGLKGYPGIAGFQGIPGESGSQGLSGVPGLPGASGLPGLKGDQGQTLGISGSPGPKGQPGESGFKGVKGKDGPVGDVGFPGNKGEDGKVGISGDVGLPGSLGLPGVAGMRGNPGLPGSPGHPGATGPLGPPGLIGTKGPSITGVPGPAGLPGPKGEKGSPGIGIGAPGKPGIRGPKGSQGFPGLQGAAGLPGALGLSLPSVIEGQPGDPGRPGLDGERGRPGPPGPPGPPGPASDQGDPGDPGFPGIPGPQGPKGDQGIPGFSGLPGELGLKGMRGEPGFMGTPGKVGPPGDPGLPGMKGKAGPRGLSGPRGAPGHTPIAEAIQAPPGPMGLPGIDGIPGLMGDPGVQGPVGLQGSKGLPGIPGKDGASGLPGPPGALGDPGLPGLQGPPGFEGAPGKPGPFGRAGVPGQSLRVGYTLVKHSQSEQVPLCPSGMSQLWVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVGQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGEEPVSETLKAGQLHTRVSRCQVCMKSV", "length": 1664, "header": "tr|A0A3Q1M906-1|A0A3Q1M1R0_BOVIN Computationally mapped isoform of Collagen type IV alpha 6 chain OS=Bos taurus OX=9913 GN=COL4A6 PE=4 SV=2 CANONICAL=A0A3Q1M1R0-1" }, "locus": { "chromosome": "X", "start_pos": 57139761, "end_pos": 56803360, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066424.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066424.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066968.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066968.2" } ] } }, { "isoform_ac": "A0A3Q1NK51-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NK51/entry", "sequence": { "sequence": "MHPGLWLLLVTLCLTEELAGAGEKKPYGKPCGGQDCSGGCKCSPEKGARGRPGPIGIQGPTGPQGLPGPSGLSGLKGERGSPGPLGPYGPKGDKGPMGVPGFLGINGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYSGLPGPPGLPGQKGSKGEPVLAQGSFKGMKGESGLPGLDGITGPQGAPGSPGAVGPRGPPGLQGPPGPPGFPGPDGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPQGFPGVSGPPGLPGFGIAGEKGEKGIPGLPGPRGPMGLEGVQGPPGSQGRKGSSGFPGLNGFPGIKGEKGGIGLPGPDIFIDTDGAVISGYPGDPGMPGLPGLKGDEGIQGLPGPPGAPGLPALPGGPGALGPQGALGLKGERGNTGRTTTGAAGLPGRDGLPGLPGLPGPPGAASETGTLQSTEPGSPGLRGERGPKGHPGLKGIKGDPGFCACDGGVPNMGPPGEPGLPGPPGLLGLPGLKGTKGDPGSGGAQGPSGDPGVFGPRGPTGPKGKKGDPTLSTRSGMPGEQGDPGPQGLPGETGAPGKDGIPGLPGLPGLLGDGAQGFPGEKGLPGLPGEKGHTGPTGPPGIGLPGAPGPRGLPGDKGVDGLPGQPGPRGVPGITLPCIIPGPYGPSGLPGAPGFPGPKGARGLPGAPGQPGLRGNKGDPGSPGLVHLPELPGFPGPHGEKGLPGFPGLPGKDGLPGKVGSPGLPGPKGAPGDILGAENGAPGEQGLQGLPGDRGFPGDSGLPGLKGLLGKSGLLGPKGERGSPGIPGRVGQPGPPGPSGLFGIKGKPGLRGPPGFPGISGYPGKKGPRGEIGLPASAGKRGLPGLKGLPGLPGPIGFLGNSGLPGATGLPGLPGLKGEKGSVGLTGFPGIPGLPGIPGASGLKGIPGSTGRVGPSGWAGSPGEKGDRGDPGPFGIPSHRPPMLNLRFKGDKGSQGSPGAIGFPGPRGDKGEAGHPGPPGLPGAPGFPSLIKGLSGRPGPPGSTGLRGLPGLKGYPGIAGFQGIPGESGSQGLSGVPGLPGASGLPGLKGDQGQTLGISGSPGPKGQPGESGFKGVKGKDGPVGDVGFPGNKGEDGKVGISGDVGLPGSLGLPGVAGMRGNPGLPGSPGHPGATGPLGPPGLIGTKGPSITGVPGPAGLPGPKGEKGSPGIGIGAPGKPGIRGPKGSQGFPGLQGAAGLPGALGLSLPSVIEGQPGDPGRPGLDGERGRPGPPGPPGPPGPASDQGDPGDPGFPGIPGPQGPKGDQGIPGFSGLPGELGLKGLSGPRGAPGHTPIAEAIQAPPGPMGLPGIDGIPGLMGDPGVQGPVGLQGSKGLPGIPGKDGASGLPGPPGALGDPGLPGLQGPPGFEGAPGKPGPFGRAGVPGQSLRVGYTLVKHSQSEQVPLCPSGMSQLWVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVGQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGEEPVSETLKAGQLHTRVSRCQVCMKSV", "length": 1631, "header": "tr|A0A3Q1NK51-1|A0A3Q1M1R0_BOVIN Computationally mapped isoform of Collagen type IV alpha 6 chain OS=Bos taurus OX=9913 GN=COL4A6 PE=4 SV=2 CANONICAL=A0A3Q1M1R0-1" }, "locus": { "chromosome": "X", "start_pos": 57139761, "end_pos": 56803360, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083333.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083333.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072627.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072627.2" } ] } }, { "isoform_ac": "A0AAA9S669-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S669/entry", "sequence": { "sequence": "MHPGLWLLLVTLCLTEELAGAGEKKPYGKPCGGQDCSGGCKCSPEKGARGRPGPIGIQGPTGPQGLPGPSGLSGLKGERGSPGPLGPYGPKGDKGPMGVPGFLGINGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYSGLPGPPGLPGQKGSKGEPVLAQGSFKGMKGESGLPGLDGITGPQGAPGSPGAVGPRGPPGLQGPPGPPGFPGPDGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPQGFPGVSGPPGLPGFGIAGEKGEKGIPGLPGPRGPMGLEGVQGPPGSQGRKGSSGFPGLNGFPGIKGEKGGIGLPGPDIFIDTDGAVISGYPGDPGMPGLPGLKGDEGIQGLPGPPGAPGLPALPGGPGALGPQGALGLKGERGNTGRTTTGAAGLPGRDGLPGLPGLPGPPGAASETGTLQSTEPGSPGLRGERGPKGHPGLKGIKGDPGFCACDGGVPNMGPPGEPGLPGPPGLLGLPGLKGTKGDPGSGGAQGPSGDPGVFGPRGPTGPKGKKGDPTLSTRSGMPGEQGDPGPQGLPGETGAPGKDGIPGLPGLPGLLGDGAQGFPGEKGLPGLPGEKGHTGPTGPPGIGLPGAPGPRGLPGDKGVDGLPGQPGPRGVPGDCCCKEEVGKTDLDTEGGITLPCIIPGPYGPSGLPGAPGFPGPKGARGLPGAPGQPGLRGNKGDPGSPGLVHLPELPGFPGPHGEKGLPGFPGLPGKDGLPGKVGSPGLPGPKGAPGDILGAENGAPGEQGLQGLPGDRGFPGDSGLPGLKGLLGKSGLLGPKGERGSPGIPGRVGQPGPPGPSGLFGIKGKPGLRGPPGFPGISGYPGKKGPRGEIGLPASAGKRGLPGLKGLPGLPGPIGFLGNSGLPGATGLPGLPGLKGEKGSVGLTGFPGIPGLPGIPGASGLKGIPGSTGRVGPSGWAGSPGEKGDRGDPGPFGIPSHRPPMLNLRFKGDKGSQGSPGAIGFPGPRGDKGEAGHPGPPGLPGAPGFPSLIKGLSGRPGPPGSTGLRGLPGLKGYPGIAGFQGIPGESGSQGLSGVPGLPGASGLPGLKGDQGQTLGISGSPGPKGQPGESGFKGVKGKDGPVGDVGFPGNKGEDGKVGISGDVGLPGSLGLPGVAGMRGNPGLPGSPGHPGATGPLGPPGLIGTKGFPGLPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGLPGPKGEKGSPGIGIGAPGKPGIRGPKGSQGLSGPRGAPGHTPIAEAIQAPPGPMGLPGIDGIPGLMGDPGVQGPVGLQGSKGLPGIPGKDGASGLPGPPGALGDPGLPGLQGPPGFEGAPGKPGPFGRAGVPGQSLRVGYTLVKHSQSEQVPLCPSGMSQLWVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVGQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGEEPVSETLKAGQLHTRVSRCQVCMKSV", "length": 1580, "header": "tr|A0AAA9S669-1|A0A3Q1M1R0_BOVIN Computationally mapped isoform of Collagen type IV alpha 6 chain OS=Bos taurus OX=9913 GN=COL4A6 PE=4 SV=1 CANONICAL=A0A3Q1M1R0-1" }, "locus": { "chromosome": "X", "start_pos": 57139761, "end_pos": 56803360, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122807.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122807.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078790.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078790.1" } ] } }, { "isoform_ac": "F1MJY9-1", "url": "https://www.uniprot.org/uniprotkb/F1MJY9/entry", "sequence": { "sequence": "MHPGLWLLLVTLCLTEELAGAGEKKPYGKPCGGQDCSGGCKCSPEKGARGRPGPIGIQGPTGPQGLPGPSGLSGLKGERGSPGPLGPYGPKGDKGPMGVPGFLGINGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYSGLPGPPGLPGQKGSKGEPVLAQGSFKGMKGESGLPGLDGITGPQGAPGSPGAVGPRGPPGLQGPPGPPGFPGPDGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPQGFPGVSGPPGLPGFGIAGEKGEKGIPGLPGPRGPMGLEGVQGPPGSQGRKGSSGFPGLNGFPGIKGEKGGIGLPGPDIFIDTDGAVISGYPGDPGMPGLPGLKGDEGIQGLPGPPGAPGLPALPGGPGALGPQGALGLKGERGNTGRTTTGAAGLPGRDGLPGLPGLPGPPGAASETGTLQSTEPGSPGLRGERGPKGHPGLKGIKGDPGFCACDGGVPNMGPPGEPGLPGPPGLLGLPGLKGTKGDPGSGGAQGPSGDPGVFGPRGPTGPKGKKGDPTLSTRSGMPGEQGDPGPQGLPGETGAPGKDGIPGLPGLPGLLGDGAQGFPGEKGLPGLPGEKGHTGPTGPPGIGLPGAPGPRGLPGDKGVDGLPGQPGPRGVPGDCCCKEEVGKTDLDTEGGITLPCIIPGPYGPSGLPGAPGFPGPKGARGLPGAPGQPGLRGNKGDPGSPGLVHLPELPGFPGPHGEKGLPGFPGLPGKDGLPGKVGSPGLPGPKGAPGDILGAENGAPGEQGLQGLPGDRGFPGDSGLPGLKGLLGKSGLLGPKGERGSPGIPGRVGQPGPPGPSGLFGIKGKPGLRGPPGFPGISGYPGKKGPRGEIGLPASAGKRGLPGLKGLPGLPGPIGFLGNSGLPGATGLPGLPGLKGEKGSVGLTGFPGIPGLPGIPGASGLKGIPGSTGRVGPSGWAGSPGEKGDRGDPGPFGIPSHRPPMLNLRFKGDKGSQGSPGAIGFPGPRGDKGEAGHPGPPGLPGAPGFPSLIKGLSGRPGPPGSTGLRGLPGLKGYPGIAGFQGIPGESGSQGLSGVPGLPGASGLPGLKGDQGQTLGISGSPGPKGQPGESGFKGVKGKDGPVGDVGFPGNKGEDGKVGISGDVGLPGSLGLPGVAGMRGNPGLPGSPGHPGATGPLGPPGLIGTKGFPGLPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGLPGPKGEKGSPGIGIGAPGKPGIRGPKGSQGFPGLQGAAGLPGALGLSLPSVIEGQPGDPGRPGLDGERGRPGPPGPPGPPGPASDQGDPGDPGFPGIPGPQGPKGDQGIPGFSGLPGELGLKGMRGEPGFMGTPGKVGPPGDPGLPGMKGKAGPRGLSGPRGAPGHTPIAEAIQAPPGPMGLPGIDGIPGLMGDPGVQGPVGLQGSKGLPGIPGKDGASGLPGPPGALGDPGLPGLQGPPGFEGAPGKPGPFGRAGVPGQSLRVGYTLVKHSQSEQVPLCPSGMSQLWVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVGQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGEEPVSETLKAGQLHTRVSRCQVCMKSV", "length": 1706, "header": "tr|F1MJY9-1|F1MJY9_BOVIN Computationally mapped isoform of Collagen type IV alpha 6 chain OS=Bos taurus OX=9913 GN=COL4A6 PE=4 SV=3 CANONICAL=A0A3Q1M1R0-1" }, "locus": { "chromosome": "X", "start_pos": 57139761, "end_pos": 56803360, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018292.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018292.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018292.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018292.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 536, "start_aa": "Thr", "end_pos": 536, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr536", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:523526", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523526", "resource": "KEGG Pathway" }, { "id": "R-BTA-1442490", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1442490", "resource": "Reactome", "description": "Collagen degradation" }, { "id": "R-BTA-1566977", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1566977", "resource": "Reactome", "description": "Fibronectin matrix formation" }, { "id": "R-BTA-1650814", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "resource": "Reactome", "description": "Collagen biosynthesis and modifying enzymes" }, { "id": "R-BTA-2022090", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022090", "resource": "Reactome", "description": "Assembly of collagen fibrils and other multimeric structures" }, { "id": "R-BTA-216083", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "resource": "Reactome", "description": "Integrin cell surface interactions" }, { "id": "R-BTA-2243919", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2243919", "resource": "Reactome", "description": "Crosslinking of collagen fibrils" }, { "id": "R-BTA-3000171", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000171", "resource": "Reactome", "description": "Non-integrin membrane-ECM interactions" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YTF5-1", "protein_name": "Collagen type IV alpha 6 chain", "gene_name": "COL4A6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQNCESFFYKFFFFFPFDKTNNCSPGCSYCIGIYVETQQGGKKSYSGPCGGRDCSAGCKCFPEKGARGRPGPIGIQGPIGAPGFTGPEGLPGAKGERGAVGPPGPAGHKGNKGSMGVPGFQGINGIPGHPGQSGPRGPPGLDGCNGTIGSPGVSGPDGFPGIPGLPGRPGPKGLKGEPVYAQGSLKGMKGENGLPGLDGISGPRGFPGPTGSAGPIGLPGLQGPVGPPGPPGPKGNMGLGFQGEKGEKGDVGLPGPPGPPPSTGILEFMGFPKGKQGEKGQPGPQGLPGDKGLPGLPGFGGVGEKGEKGVPGLPGGRGLLGLDGSNGIPGRKGHPGIPGYPGLDGVEGTKGEIGDIGPPGPPIIVDKEGVVISGAPGDPGNPGIPGPPGDEGISGLPGFPGAPGFPGLERDGMGPGGSPGIPGVKGEMGEPGRTTVGLPGTPGRIGLPGLPGAPGLPGSSRPSLLPDAILDGRTGAPGEPGQRGLPGALGPKGYKGDAGDCACDGGVTRAGIKGISGPQGPPGSRGVPGIKGVSGDPGTVGAPGLQGPLASAGQQGLPGLKGEKGDSSYATGRGAPGDRGAAAPRGPSGFPGTPGRDGLPGLPGPPGPPGDGGLGFPGEKGLPGLPGSKGRPGEIGSPGIGYPGPAGLRGPPGDPGMDGFPGQAGLPGPPGITLPCVVPGAYGPPGTPGLPGLPGPKGSKGFPGIPGQPGLHGSKGQPGSPGIIGLQGEPGFPGPRGEQGSQGLPGLDGTDGLPGKMGASGLAGTKGATGDVFGAESGAQGERGRPGLPGDKGLAGDLGFPGPKGLDGRPGLLGIKGELGNPGYSGVPGLRGPPGPGGPFGIKGKPGPLGSVGLAGAPGLPGVKGLSGDVGPQGPAGMKGFPGLDGAPGPPGERGFLGPPGPFGQDGRPGFSGPKGEKGSSGLLGFPGMPGLPGVPGVNGFKGTPGAVGERGSPGVLGLQGQKGDRGDVGPPGLPVLGAQEQALQLKGDKGDPGLAGLGGFPGPRGDKGIPGSRGQLGLPGPVGSASRERGFHGDQGFPGPSGQPGLPGQKGTRGIIGFPGMPGERGSDGVTGTLGFPGPIGLPGPKGDQGESAGVPGTAGVKGERGDPGFPGERGREGLKGEPGYPGSTGVNGLKGGPGDLGPEGPAGIPGNAGLRGISGPPGPPGQPGSVGFPGARGTAGPKGFHGFPGLNGLNGLPGTKGSPGTPGLSEVGLKGPAGLPGLKGEEGSPGLGRGAVGFPGPKGSSGDLGPPGPVGLPGLPGTPGVSLPSDIRGRPGDAGHPGLDGSSGLPGPPGQRGPPGPAFDQGDTGNPGFPGVPGLRGGKGDVGPTGPIGLPGVSGFKGVRGEPGLMGMPGKDGPPGDPGYPGQKGGMGHRGLPGQPGAPGITPQAEEITAPAGLPGLPGIDGVPGFDGDPGFQGPVGKPGAKGLPGRSGLKGRDGLPGSPGIAGDPGPVGAPGPQGFEGAAGKPGALGLPGMPGRSVGVGYTLVKHSQSDQIPPCPIGMNKLWDGYSLLYVEGQEKSHNQDLGFAGSCLPRFSTMPFIYCNINEVCYYASRNDKSYWLSTTAPIPMMPVDSNQIPQYISRCSVCEAPSQAVAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATPFIECNGARGTCHYFANKYSFWLTTVEQSQQFVGAPPSETLKAGQLRTRVSRCQVCMKNL", "length": 1710 }, "evidence": [ { "id": "A0A3Q1M1R0", "url": "https://omabrowser.org/oma/group/A0A3Q1M1R0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0M462-1", "protein_name": "Collagen type IV alpha 6 chain", "gene_name": "Col4a6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 1728 }, "evidence": [ { "id": "A0A3Q1M1R0", "url": "https://omabrowser.org/oma/group/A0A3Q1M1R0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B1AVK5-1", "protein_name": "Collagen, type IV, alpha 6", "gene_name": "Col4a6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHPGLWLFLVSLCLTKELAESGQKMSYGKPCGSRDCHGVCTCFPEKGARGHPGPIGTQGPAGPEGFTGPTGLSGLKGERGSPGPLGPYGSKGDKGPIGVPGFVGISGIPGHPGQPGPRGPPGPDGCNGTQGAVGFPGPDGYPGILGPPGLPGHKGAKGEPVPFQGSITGIRGDPGLPGLDGIPGPSGSSGSPGDAGPIGPPGLQGPPGLPGLPGPEGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPPGFPGMSGPPGVPEFGSTGEKGEKGILGLPGPRGPMGSEGIQGHPGRQGKKGTSGFPGINGFPGIKGEKGDIGVRGPDSFTDADGAVISGYPGDPGVLGLPGLRGDEGVQGQRGPSGTPGLPSLTGLPGALGPQGFPGLKGDQGNSGRTTFGEAGLPGRVGLPGLPGLPGPSGPPGRTFETGHLSNIEPGFPGLQGEQGPKGHQGLKGVKGDSGFCACEGGAPNIGPHGEPGLPGIQGPIGLQGFKGTKGDPGSRGASGPAGTPGLFGPRGQTGLKGKKGEPTVSRGSKMSGDKGDPGPQGTPGLAGTPGKDGRPGLPGLPGIQGDGGSGFPGERGLPGLPGEKGHDGPIGPPGIGLPGPPGPRGLPGDKGVDGLPGQQGLRGAQGVTLPCIIPGSYGPSGFPGAPGFPGSKGARGLPGIPGKPGTHGSKGGPGSPGLMHLPGLPGFPGVRGEKGLPGFPGLPGKDGYPGKAGSPGLPGFKGAAGDIFGAENGASGEQGLQGLPGDKGFPGDSGLPGPKGLNGKPGMLGPKGERGNPGTSGPPGQPGPSGSTDPFGIKGTSGFPGAPGLPGISGHPGKKGQRGDIGQPGSTGKRGLPGIKGLPGPQGSPGFLGSPGLSGVTGLPGIEGQKGEKGSSGPVGFPGLPGLPGLPGADGLKGFSGSFGKVGQPGQTGTSGEKGDRGDPGPVGISSPRPPMLNLWFKGEKGSRGSAGSDGFPGPRGDKGEPGIPGLPGPPGATGQTNTIKGLNGRPGSPGSMGRRGLPGLKGSLGIAGFPGMPGKSGSQGLTGTSGLLGATGIPGLKGDQGQTLGISGSPGPKGQPGELGFKGVKGKDGLVGDRGYPGNKGDGGKVGITGDPGFPGSPGLQGISGMNGDPGLPGSSGHLGSIGRPGPSGLIGPKGFPGAPGLHGLNGLPGTKGTHGTPGASITGVPGPAGLPGPKGERGVPGIVIGDPGKQGSKGQKGDQGSPGLQGPAGTPGAPGISLPSVIAGQPGDPGRPGLDGERGRPGPPGPPGPPGPSSDQGDPGDSGFPGIPGLQGFKGNQGLPGFSGLSGELGLKGMRGEPGLMGTPGKIGQPGDPGFPGMKGKAGPRGFSGPQGAPGHTPIAEAMQVPPGPLGLPGIDGIPGLIGDPGSQGSVGLQGSKGLPGIPGKDGPSGLPGPSGILGDPGLPGLQGPPGFEGAPGNQGPIGQPGMPGHGVRVGYTLVKHSQSEQVPLCPTGMSRLWVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVGQTQIPQYISRCSVCEAPSQAIAVHSQDIIVPQCPLGWHSLWIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERGQFREEPVSETLKTGQLHTRVSRCQVCMKTP", "length": 1691 }, "evidence": [ { "id": "A0A3Q1M1R0", "url": "https://omabrowser.org/oma/group/A0A3Q1M1R0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q14031-1", "protein_name": "Collagen alpha-6(IV) chain", "gene_name": "COL4A6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLINKLWLLLVTLCLTEELAAAGEKSYGKPCGGQDCSGSCQCFPEKGARGRPGPIGIQGPTGPQGFTGSTGLSGLKGERGFPGLLGPYGPKGDKGPMGVPGFLGINGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPVLAPGSFKGMKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPKGFPGISGPPGFPGLGTTGEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQGIEGQKGDIGLPGPDVFIDIDGAVISGNPGDPGVPGLPGLKGDEGIQGLRGPSGVPGLPALSGVPGALGPQGFPGLKGDQGNPGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETETLHNKESGFPGLRGEQGPKGNLGLKGIKGDSGFCACDGGVPNTGPPGEPGPPGPWGLIGLPGLKGARGDRGSGGAQGPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPGDRGDSGSQGFRGVIGEPGKDGVPGLPGLPGLPGDGGQGFPGEKGLPGLPGEKGHPGPPGLPGNGLPGLPGPRGLPGDKGKDGLPGQQGLPGSKGITLPCIIPGSYGPSGFPGTPGFPGPKGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELPGFPGPRGEKGLPGFPGLPGKDGLPGMIGSPGLPGSKGATGDIFGAENGAPGEQGLQGLTGHKGFLGDSGLPGLKGVHGKPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPGISGHPGKKGTRGKKGPPGSIVKKGLPGLKGLPGNPGLVGLKGSPGSPGVAGLPALSGPKGEKGSVGFVGFPGIPGLPGIPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNPGPVGIPSPRRPMSNLWLKGDKGSQGSAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPGFMGIRGLPGLKGSSGITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSPGPKGQPGESGFKGTKGRDGLIGNIGFPGNKGEDGKVGVSGDVGLPGAPGFPGVAGMRGEPGLPGSSGHQGAIGPLGSPGLIGPKGFPGFPGLHGLNGLPGTKGTHGTPGPSITGVPGPAGLPGPKGEKGYPGIGIGAPGKPGLRGQKGDRGFPGLQGPAGLPGAPGISLPSLIAGQPGDPGRPGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGPKGDQGIPGFSGLPGELGLKGMRGEPGFMGTPGKVGPPGDPGFPGMKGKAGPRGSSGLQGDPGQTPTAEAVQVPPGPLGLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKDGPSGLPGPPGALGDPGLPGLQGPPGFEGAPGQQGPFGMPGMPGQSMRVGYTLVKHSQSEQVPPCPIGMSQLWVGYSLLFVEGQEKAHNQDLGFAGSCLPRFSTMPFIYCNINEVCHYARRNDKSYWLSTTAPIPMMPVSQTQIPQYISRCSVCEAPSQAIAVHSQDITIPQCPLGWRSLWIGYSFLMHTAAGAEGGGQSLVSPGSCLEDFRATPFIECSGARGTCHYFANKYSFWLTTVEERQQFGELPVSETLKAGQLHTRVSRCQVCMKSL", "length": 1691 }, "evidence": [ { "id": "A0A3Q1M1R0", "url": "https://omabrowser.org/oma/group/A0A3Q1M1R0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1R0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1R0" } ], "pmid": "" }, { "name": "collagen-activated tyrosine kinase receptor signaling pathway", "id": "GO:0038063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038063", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1R0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1R0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1R0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1R0" } ], "pmid": "" }, { "name": "collagen type IV trimer", "id": "GO:0005587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005587", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1R0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1R0" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1R0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1R0" } ], "pmid": "" }, { "name": "collagen trimer", "id": "GO:0005581", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005581", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1R0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1R0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "extracellular matrix structural constituent conferring tensile strength", "id": "GO:0030020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1R0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1R0" } ], "pmid": "" }, { "name": "extracellular matrix structural constituent", "id": "GO:0005201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005201", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1R0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1R0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M1R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1R0" }, { "id": "PS51403", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51403" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Collagen IV NC1", "eco_id": "ECO_0000259", "start_pos": 1464, "end_pos": 1688, "start_aa": "Gly", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 536 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", 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"comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q9GMA3-1", "uniprot_ac": "Q9GMA3", "uniprot_id": "VSX1_BOVIN", "mass": { "chemical_mass": 38526.0, "monoisotopic_mass": 38526.0 }, "refseq": { "ac": "NP_777192", "name": "visual system homeobox 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777192" }, "gene_names": [ { "name": "VSX1", "type": "recommended", "evidence": [ { "id": "Q9GMA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3" } ] }, { "name": "RINX", "type": "synonym", "evidence": [ { "id": "NP_777192", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777192" }, { "id": "Q9GMA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3" } ] }, { "name": "VSX1", "type": "synonym", "evidence": [ { "id": "NP_777192", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777192" } ] } ], "protein_names": [ { "name": "Visual system homeobox 1", "type": "recommended", "evidence": [ { "id": "Q9GMA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3/entry#names_and_taxonomy" } ] }, { "name": "Homeodomain protein RINX", "type": "synonym", "evidence": [ { "id": "Q9GMA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3/entry#names_and_taxonomy" } ] }, { "name": "Retinal inner nuclear layer homeobox protein", "type": "synonym", "evidence": [ { "id": "Q9GMA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3/entry#names_and_taxonomy" } ] }, { "name": "Transcription factor VSX1", "type": "synonym", "evidence": [ { "id": "Q9GMA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3/entry#names_and_taxonomy" } ] }, { "name": "homeodomain protein RINX", "type": "synonym", "evidence": [ { "id": "NP_777192", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777192" } ] }, { "name": "retinal inner nuclear layer homeobox protein", "type": "synonym", "evidence": [ { "id": "NP_777192", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777192" } ] }, { "name": "transcription factor VSX1", "type": "synonym", "evidence": [ { "id": "NP_777192", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777192" } ] }, { "name": "visual system homeobox 1", "type": "synonym", "evidence": [ { "id": "NP_777192", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777192" } ] } ], "function": [ { "annotation": "Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster (By similarity). May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9GMA3", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3#function" }, { "database": "UniProtKB", "id": "Q91V10", "url": "https://www.uniprot.org/uniprotkb/Q91V10#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9GMA3", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VSX1", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3", "locus": { "chromosome": "13", "start_pos": 42691095, "end_pos": 42699941, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003335", "url": "https://www.ensembl.org/id/ENSBTAG00000003335" } ] } } ], "crossref": [ { "id": "Q9GMA3", "url": "https://alphafold.ebi.ac.uk/entry/Q9GMA3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003335", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003335", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "286802", "url": "https://www.ncbi.nlm.nih.gov/gene/286802", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023339", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023339", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:286802", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286802", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WGSDHLK", "url": "https://omabrowser.org/oma/group/WGSDHLK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q9GMA3", "url": "https://www.orthodb.org/?gene=Q9GMA3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24323", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24323", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24323:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24323:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_777192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777192", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DIK2", "url": "https://www.uniprot.org/uniprotkb/A0A452DIK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIK2-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIK2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9GMA3", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9GMA3-1", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTGRDALSDGRARSRALVPGGPSTGSRPRGFAITDLLGLEAELPAPEGPGPGSGCEGPAAAPRAGPGLGGSCPARGALPLGLGLLCGFGAQPPAAARAPCLLLADVPFLPPEGPEPLAPRFPGRPPPSAARQKRSESVSTSDEDSPSEDRSDRKASPAPSKRKKRRHRTVFTAHQLEELEKAFSEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGAMVRHCIPLPDSVLGSGEGGLLGSCAPWLLGMHKKSAGTIRKAESEEKLAGLWGSDHLKEGSSPHQAGPQRGLEEGSPVSGVEDVVIDLSSSTRQETDRAQQGVGAQGRPDSEGLEGLQPGKEGAL", "length": 365, "header": "sp|Q9GMA3-1|VSX1_BOVIN Isoform 1 of Visual system homeobox 1 OS=Bos taurus OX=9913 GN=VSX1 PE=2 SV=1 CANONICAL=Q9GMA3-1" }, "isoforms": [ { "isoform_ac": "A0A452DIK2-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIK2/entry", "sequence": { "sequence": "MTGRDALSDGRARSRALVPGGPSTGSRPRGFAITDLLGLEAELPAPEGPGPGSGCEGPAAAPRAGPGLGGSCPARGALPLGLGLLCGFGAQPPAAARAPCLLLADVPFLPPEGPEPLAPRFPGRPPPSAALQKRSESVSTSDEDSPSEDRSDRKASPAPSKRKKRRHRTVFTAHQLEELEKAFSEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGAMVRHCIPLPDSVLGSGEGGLLGSCAPWLLGMHKKSAGTIRKAESEEKLAGLWGSDHLKEGSSPHQAGPQRGLEEGSPVSGVEDVVIDLSSSTRQETDRAQQGVGAQGRPDSEGLEGLQPGKEGAL", "length": 365, "header": "tr|A0A452DIK2-1|VSX1_BOVIN Computationally mapped isoform of Visual system homeobox 1 OS=Bos taurus OX=9913 GN=VSX1 PE=2 SV=1 CANONICAL=Q9GMA3-1" }, "locus": { "chromosome": "13", "start_pos": 42699650, "end_pos": 42691900, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004329.6", "url": "https://www.ensembl.org/id/ENSBTAT00000004329.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004329.6", "url": "https://www.ensembl.org/id/ENSBTAP00000004329.6" } ] } }, { "isoform_ac": "A0AAA9RZV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZV0/entry", "sequence": { "sequence": "MTGRDALSDGRARSRALVPGGPSTGSRPRGFAITDLLGLEAELPAPEGPGPGSGCEGPAAAPRAGPGLGGSCPARGALPLGLGLLCGFGAQPPAAARAPCLLLADVPFLPPEGPEPLAPRFPGRPPPSAALQKRSESVSTSDEDSPSEDRSDRKASPAPSKRKKRRHRTVFTAHQLEELEKAFSEAHYPDVYAREMLAMKTELPEDRIQVQGPPLLKDTETTLFSHAASQPTATSKQ", "length": 237, "header": "tr|A0AAA9RZV0-1|VSX1_BOVIN Computationally mapped isoform of Visual system homeobox 1 OS=Bos taurus OX=9913 GN=VSX1 PE=2 SV=1 CANONICAL=Q9GMA3-1" }, "locus": { "chromosome": "13", "start_pos": 42699650, "end_pos": 42696024, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114840.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114840.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075341.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075341.1" } ] } }, { "isoform_ac": "Q9GMA3-1", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3/entry#Q9GMA3-1", "sequence": { "sequence": "MTGRDALSDGRARSRALVPGGPSTGSRPRGFAITDLLGLEAELPAPEGPGPGSGCEGPAAAPRAGPGLGGSCPARGALPLGLGLLCGFGAQPPAAARAPCLLLADVPFLPPEGPEPLAPRFPGRPPPSAARQKRSESVSTSDEDSPSEDRSDRKASPAPSKRKKRRHRTVFTAHQLEELEKAFSEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGAMVRHCIPLPDSVLGSGEGGLLGSCAPWLLGMHKKSAGTIRKAESEEKLAGLWGSDHLKEGSSPHQAGPQRGLEEGSPVSGVEDVVIDLSSSTRQETDRAQQGVGAQGRPDSEGLEGLQPGKEGAL", "length": 365, "header": "sp|Q9GMA3-1|VSX1_BOVIN Isoform 1 of Visual system homeobox 1 OS=Bos taurus OX=9913 GN=VSX1 PE=2 SV=1 CANONICAL=Q9GMA3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "RINX(VSX1), a novel homeobox gene expressed in the inner nuclear layer of the adult retina.", "journal": "Genomics", "date": "2000", "authors": "Hayashi T, Huang J, Deeb SS", "evidence": [ { "database": "UniProtKB", "id": "Q9GMA3", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3" } ], "reference": [ { "type": "PubMed", "id": "10903837", "url": "https://glygen.org/publication/PubMed/10903837" } ] } ], "pathway": [ { "id": "bta:286802", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286802", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z532-1", "protein_name": "Visual system homeobox 1", "gene_name": "VSX1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPGRAEPSGGRAAVPVPLPVAVAAAPSPASVRSALPERSARPGGAGLRAKGFAITDLLGLEAELQPPPGAAPGPAGGYEGGGALGLGLGLLCGLAGPGAPCLLPAPLPLLPARGPRPGPPGPPPAARRHKESASDEDSLSGDASELKMPASQIKRKKRRHRTVFTAHQLEELEKAFNEAHYPDVYAREMLAVKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESIINSAKSGLVGSCAPWLLGMHKKSMEVSRKAESQEKPADGWQAEQDGEELQGKQASSQRSSEKLGPAKDPEDTAIDLSRTAKQEKRSVLRQCINGDPSTEQKDRDH", "length": 350 }, "evidence": [ { "id": "Q9GMA3", "url": "https://omabrowser.org/oma/group/Q9GMA3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZQZ0-1", "protein_name": "Visual system homeobox 1", "gene_name": "Vsx1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTGRDGLLDGRSRSRALAPGCPPTGSRLRSFAINDLLGLEADLPTPAEPGLRSNCEAPAEATGPGPGPGLCGTCPARGALPLGLGLLCGFGAQPPSATAARARCLLLADLRLLPPAGPEPAVAQSPVHPPPALGSQQRSENISTSDGDSPSEEKNDPKMSLTLGKRKKRRHRTVFTAHQLEELEKAFGEAHYPDVYAREMLAVKTELPEDRIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGAMVRHCIPLPDSVLNSADSLQGSCAPWLLGMHKKSTEMRKPESEEKLAGLWELDHLRKGAKKDEDGPERGPGKASLNPEGSLEDVAIDLSSSSRQETKKMPSGSSTQGCTHAPGPQVLQPPQVGAS", "length": 369 }, "evidence": [ { "id": "Q9GMA3", "url": "https://omabrowser.org/oma/group/Q9GMA3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LGC8-1", "protein_name": "Visual system homeobox 1", "gene_name": "VSX1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTGRDALSDGCARSRALVPGGPPTGSRPRGFAITDLLGLEAELPAPAGPGPGSCCEGPAAAPCAGPGLGDSGLARGALPLGFGLLCSFGAQPPAAAGAPCLLLADVPFLPPEGPEPPAPHVLGRSPPTSIRQKRSESVSTSEEDSLPEDRSDLKLPPTPGKRKKRRHRTVFTAHQLEELEKAFSEAHYPDVYAREMLAVKTELPEDRIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGAMVRHCIPPPDSVLSSAEGGLLGSCAPWLLGMHKKSTGMIKKAESEEKLAGLWGSDHLKEGFSPLQAGPQRGSDEGSPESGQDVAMDLSNSTRQEAKRAPQEAGTQGCSDSEELKGLQPRKGEAL", "length": 364 }, "evidence": [ { "id": "Q9GMA3", "url": "https://omabrowser.org/oma/group/Q9GMA3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q91V10-1", "protein_name": "Visual system homeobox 1", "gene_name": "Vsx1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTGRDGLSDARSRSRALAPGCPPTGSRLRSFAINDLLGLEADLPTPAEPGLRSNSGDPAEAIGSGPGPGPGLCGSCPARGALPLGLGLLCGFGAQPPSAAAAARARCLLLADLRLLPSAGPEPAVAQGPVHPPPALGSQQRSESVSTSDGDSPSEEKNDPKMSLILGKRKKRRHRTVFTAHQLEELEKAFGEAHYPDVYAREMLAAKTELPEDRIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGAMVRHCIPLPDSVLNSADSLQGSCAPWLLGMHKKSTGMRKPESEDKLAGLWEFDHLKKGANKDEDGPERGPDETTQNPENSLEDVAIDLSSSSRQETKKMPPGSSTQLPQPPQVGAS", "length": 363 }, "evidence": [ { "id": "Q9GMA3", "url": "https://omabrowser.org/oma/group/Q9GMA3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NZR4-1", "protein_name": "Visual system homeobox 1", "gene_name": "VSX1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTGRDSLSDGRTSSRALVPGGSPRGSRPRGFAITDLLGLEAELPAPAGPGQGSGCEGPAVAPCPGPGLDGSSLARGALPLGLGLLCGFGTQPPAAARAPCLLLADVPFLPPRGPEPAAPLAPSRPPPALGRQKRSDSVSTSDEDSQSEDRNDLKASPTLGKRKKRRHRTVFTAHQLEELEKAFSEAHYPDVYAREMLAVKTELPEDRIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGAMVRHCIPLPDSVLNSAEGGLLGSCAPWLLGMHKKSMGMIRKPGSEDKLAGLWGSDHFKEGSSQSESGSQRGSDKVSPENGLEDVAIDLSSSARQETKKVHPGAGAQGGSNSTALEGPQPGKVGAT", "length": 365 }, "evidence": [ { "id": "Q9GMA3", "url": "https://omabrowser.org/oma/group/Q9GMA3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9GMA3", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q9GMA3", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "Q9GMA3", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "Q9GMA3", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "Q9GMA3", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "Q9GMA3", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q9GMA3", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q9GMA3", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9GMA3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 365, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9GMA3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9GMA3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q9GMA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3" }, { "id": "PRU00829", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00829" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CVC", "eco_id": "ECO_0000255", "start_pos": 224, "end_pos": 277, "start_aa": "Lys", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "Q9GMA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GMA3" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000255", "start_pos": 164, 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"url": "https://www.ebi.ac.uk/interpro/entry/IPR000866", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024706", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024706", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050217", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050217", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:286793", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286793", "database": "KEGG Pathway", "categories": [ 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"header": "tr|A0AAA9SS04-1|PRDX2_BOVIN Computationally mapped isoform of Peroxiredoxin-2 OS=Bos taurus OX=9913 GN=PRDX2 PE=2 SV=1 CANONICAL=Q9BGI3-1" }, "locus": { "chromosome": "7", "start_pos": 12733139, "end_pos": 12730973, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131677.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131677.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089166.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089166.1" } ] } }, { "isoform_ac": "Q9BGI3-1", "url": "https://www.uniprot.org/uniprotkb/Q9BGI3/entry#Q9BGI3-1", "sequence": { "sequence": "MACVCKAHVGKPAPEFQATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIVAFSDRAAEFHKLNCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRKLSSDYGVLKEDEGIAYRGLFVIDGKGVLRQVTINDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWTPGSDTIKPNVDDSKEYFSKHN", "length": 199, "header": "sp|Q9BGI3-1|PRDX2_BOVIN Isoform 1 of Peroxiredoxin-2 OS=Bos taurus OX=9913 GN=PRDX2 PE=2 SV=1 CANONICAL=Q9BGI3-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 178, "start_aa": "Thr", "end_pos": 178, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr178", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [ { "start_pos": 113, "end_pos": 113, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI3", "url": "https://www.uniprot.org/uniprotkb/Q9BGI3" } ], "site_lbl": "Ser113" }, { "start_pos": 183, "end_pos": 183, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", 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"MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSNRAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKTDEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN", "length": 198 }, "evidence": [ { "id": "Q9BGI3", "url": "https://omabrowser.org/oma/group/Q9BGI3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P35704-1", "protein_name": "Peroxiredoxin-2", "gene_name": "Prdx2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASGNAHIGKPAPDFTGTAVVDGAFKEIKLSDYRGKYVVLFFYPLDFTFVCPTEIIAFSDHAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTKSLSQNYGVLKNDEGIAYRGLFIIDAKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN", "length": 198 }, "evidence": [ { "id": "Q9BGI3", "url": "https://omabrowser.org/oma/group/Q9BGI3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61171-1", "protein_name": "Peroxiredoxin-2", "gene_name": "Prdx2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASGNAQIGKSAPDFTATAVVDGAFKEIKLSDYRGKYVVLFFYPLDFTFVCPTEIIAFSDHAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTKSLSQNYGVLKNDEGIAYRGLFIIDAKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN", "length": 198 }, "evidence": [ { "id": "Q9BGI3", "url": "https://omabrowser.org/oma/group/Q9BGI3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8K3U7-1", "protein_name": "Peroxiredoxin-2", "gene_name": "PRDX2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASGNAHIGKPAPDFTATAVVDGAFKEVKLSDYRGKYVVLFFYPLDFTFVCPTEIIAFSNHAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRSLSENYGVLKTDEGIAYRGLFIIDAKGILRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN", "length": 198 }, "evidence": [ { "id": "Q9BGI3", "url": "https://omabrowser.org/oma/group/Q9BGI3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI3", "url": "https://www.uniprot.org/uniprotkb/Q9BGI3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI3", "url": "https://www.uniprot.org/uniprotkb/Q9BGI3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI3", "url": "https://www.uniprot.org/uniprotkb/Q9BGI3" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI3", "url": "https://www.uniprot.org/uniprotkb/Q9BGI3" } ], "pmid": "" }, { "name": "cell redox homeostasis", "id": "GO:0045454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045454", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI3", "url": "https://www.uniprot.org/uniprotkb/Q9BGI3" } ], "pmid": "" }, { "name": "removal of superoxide radicals", "id": "GO:0019430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019430", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI3", "url": "https://www.uniprot.org/uniprotkb/Q9BGI3" } ], "pmid": "" }, { "name": "positive regulation of blood coagulation", "id": "GO:0030194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030194", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI3", "url": "https://www.uniprot.org/uniprotkb/Q9BGI3" } ], "pmid": "" }, { "name": "hydrogen peroxide catabolic process", "id": "GO:0042744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042744", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI3", "url": "https://www.uniprot.org/uniprotkb/Q9BGI3" } ], "pmid": "" }, { "name": "leukocyte activation", "id": "GO:0045321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045321", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI3", "url": "https://www.uniprot.org/uniprotkb/Q9BGI3" } ], "pmid": "" }, { "name": "defense response to tumor cell", "id": "GO:0002357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002357", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI3", "url": "https://www.uniprot.org/uniprotkb/Q9BGI3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "thioredoxin peroxidase activity", "id": "GO:0008379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008379", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI3", "url": "https://www.uniprot.org/uniprotkb/Q9BGI3" } ], "pmid": "" }, { "name": "thioredoxin-dependent peroxiredoxin activity", "id": "GO:0140824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140824", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI3", "url": "https://www.uniprot.org/uniprotkb/Q9BGI3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "62620", "name": "", "equation": "a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35705-1", "Q5E947-1", "Q9BGI1-1", "Q9BGI2-1", "Q9BGI3-1" ], "evidence": [ { "id": "62620", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/62620" } ] }, { "id": "R-BTA-3341343", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-29408", "R-BTA-66000" ], "output_participant_list": [], "enzyme_list": [ "Q5E947-1", "Q9BGI1-1", "Q9BGI3-1" ], "evidence": [ { "id": "R-BTA-3341343", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3341343" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29408", "participant_name": "H2O2 [cytosol]", "crossref": [ { "id": "16240", "database": "ChEBI", "url": "" }, { "id": "C00027", "database": "COMPOUND", "url": "" }, { "id": "11533079", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0003125", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-BTA-66000", "participant_name": "TXN [cytosol]", "crossref": [ { "id": "O97680", "database": "UniProt", "url": "" }, { "id": "NP_776393.1", "database": "RefSeq", "url": "" }, { "id": "56751", "database": "VGNC", "url": "" } ] } ], 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Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3'. Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle.", "evidence": [ { "database": "UniProtKB", "id": "Q9N181", "url": "https://www.uniprot.org/uniprotkb/Q9N181#function" }, { "database": "UniProtKB", "id": "O60551", "url": "https://www.uniprot.org/uniprotkb/O60551#function" } ] }, { "annotation": "Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSM9#function" }, { "database": "UniProtKB", "id": "RU000586", "url": "https://www.uniprot.org/uniprotkb/RU000586#function" }, { "database": "UniProtKB", "id": "A0AAA9TUK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUK5#function" }, { "database": "UniProtKB", "id": "G3N0U1", "url": "https://www.uniprot.org/uniprotkb/G3N0U1#function" }, { "database": "UniProtKB", "id": "A0AAF6ZI67", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZI67#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9N181", "url": "https://www.uniprot.org/uniprotkb/Q9N181" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NMT2", "url": "https://www.uniprot.org/uniprotkb/Q9N181", "locus": { "chromosome": "13", "start_pos": 29631097, "end_pos": 29742474, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007703", "url": "https://www.ensembl.org/id/ENSBTAG00000007703" } ] } } ], "crossref": [ { "id": "Q9N181", "url": "https://alphafold.ebi.ac.uk/entry/Q9N181", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007703", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007703", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "2.3.1.97", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.1.97&UniProtAcc=Q9N181", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "282049", "url": "https://www.ncbi.nlm.nih.gov/gene/282049", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022676", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022676", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022678", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022678", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282049", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282049", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CPAMESE", "url": "https://omabrowser.org/oma/group/CPAMESE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q9N181", "url": "https://www.orthodb.org/?gene=Q9N181", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11377", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11377", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11377:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11377:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01233", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01233", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02799", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02799", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2514859", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_776881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776881", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "15521", "url": "https://www.rhea-db.org/rhea/15521", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "70671", "url": "https://www.rhea-db.org/rhea/70671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SSM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZI67", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZI67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZI67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZI67-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0U1", "url": "https://www.uniprot.org/uniprotkb/G3N0U1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0U1-1", "url": "https://www.uniprot.org/uniprotkb/G3N0U1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9N181", "url": "https://www.uniprot.org/uniprotkb/Q9N181", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9N181-1", "url": "https://www.uniprot.org/uniprotkb/Q9N181-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGDLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQPPSKNSTIPVQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLNEVITSHGAIEADKENVRQEPYSLPQGFMWDTLDLGNAEVLRELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDATKTSGLRPMEPRDIKAVQELTNTYLKQFHLAPVMDEEEVAHWFLPQEHIIDTFVVENSSGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALIIAKLKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTESEKVGLVLQ", "length": 498, "header": "sp|Q9N181-1|NMT2_BOVIN Isoform 1 of Glycylpeptide N-tetradecanoyltransferase 2 OS=Bos taurus OX=9913 GN=NMT2 PE=2 SV=1 CANONICAL=Q9N181-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSM9/entry", "sequence": { "sequence": "MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGPGGDLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQPPSKNSTIPVQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLNEVITSHGAIEADKENVRQEPYSLPQGFMWDTLDLGNAEVLRELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDATKTSGLRPMEPRDIKAVQELTNTYLKQFHLAPVMDEEEVAHWFLPQEHIIDTFVVENSSGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALIIAKLKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTESEKVGLVLQ", "length": 497, "header": "tr|A0AAA9SSM9-1|NMT2_BOVIN Computationally mapped isoform of Glycylpeptide N-tetradecanoyltransferase 2 OS=Bos taurus OX=9913 GN=NMT2 PE=2 SV=1 CANONICAL=Q9N181-1" }, "locus": { "chromosome": "13", "start_pos": 29742318, "end_pos": 29683439, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095928.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095928.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088340.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088340.1" } ] } }, { "isoform_ac": "A0AAA9TUK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUK5/entry", "sequence": { "sequence": "MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGDLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQPPSKNSTIPVQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLNEVITSHGAIEADKENVRQEPYSLPQGFMWDTLDLGNAEVLRELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDATKTSGLRPMEPRDIKAVQELTNTYLKQFHLAPVMDEEEVAHWFLPQEHIIDTFVVENSSGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALIIAKLENSFEIFYC", "length": 455, "header": "tr|A0AAA9TUK5-1|NMT2_BOVIN Computationally mapped isoform of Glycylpeptide N-tetradecanoyltransferase 2 OS=Bos taurus OX=9913 GN=NMT2 PE=2 SV=1 CANONICAL=Q9N181-1" }, "locus": { "chromosome": "13", "start_pos": 29742318, "end_pos": 29685878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118630.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118630.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100249.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100249.1" } ] } }, { "isoform_ac": "A0AAF6ZI67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZI67/entry", "sequence": { "sequence": "MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGDLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQPPSKNSTIPVQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLNEVITSHGAIEADKENVRQEPYSLPQGFMWDTLDLGNAEVLRELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDATKTSGLRPMEPRDIKAVQELTNTYLKQFHLAPVMDEEEVAHWFLPQEHIIDTFVVELLSHLLLASVVSVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALIIAKLKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTESEKVGLVLQ", "length": 492, "header": "tr|A0AAF6ZI67-1|NMT2_BOVIN Computationally mapped isoform of Glycylpeptide N-tetradecanoyltransferase 2 OS=Bos taurus OX=9913 GN=NMT2 PE=2 SV=1 CANONICAL=Q9N181-1" }, "locus": { "chromosome": "13", "start_pos": 29742318, "end_pos": 29683439, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050460.5", "url": "https://www.ensembl.org/id/ENSBTAT00000050460.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047156.4", "url": "https://www.ensembl.org/id/ENSBTAP00000047156.4" } ] } }, { "isoform_ac": "G3N0U1-1", "url": "https://www.uniprot.org/uniprotkb/G3N0U1/entry", "sequence": { "sequence": "MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGDLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQPPSKNSTIPVQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLNEVITSHGAIEADKENVRQEPYSLPQGFMWDTLDLGNAEVLRELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDATKTSGLRPMEPRDIKAVQELTNTYLKQFHLAPVMDEEEVAHWFLPQEHIIDTFVVEVKIRTLECLSPSSVSMTHCFYTKLLLTLLEQAVLTVFIPGTRAHFYYLIMGNQDTALMLPFNTVLLLQNWLEVNCLCSRWHNSITSFNLVLICKRFSIG", "length": 489, "header": "tr|G3N0U1-1|NMT2_BOVIN Computationally mapped isoform of Glycylpeptide N-tetradecanoyltransferase 2 OS=Bos taurus OX=9913 GN=NMT2 PE=2 SV=3 CANONICAL=Q9N181-1" }, "locus": { "chromosome": "13", "start_pos": 29742318, "end_pos": 29690213, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065061.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065061.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055459.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055459.3" } ] } }, { "isoform_ac": "Q9N181-1", "url": "https://www.uniprot.org/uniprotkb/Q9N181/entry#Q9N181-1", "sequence": { "sequence": "MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGDLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQPPSKNSTIPVQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLNEVITSHGAIEADKENVRQEPYSLPQGFMWDTLDLGNAEVLRELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDATKTSGLRPMEPRDIKAVQELTNTYLKQFHLAPVMDEEEVAHWFLPQEHIIDTFVVENSSGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALIIAKLKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTESEKVGLVLQ", "length": 498, "header": "sp|Q9N181-1|NMT2_BOVIN Isoform 1 of Glycylpeptide N-tetradecanoyltransferase 2 OS=Bos taurus OX=9913 GN=NMT2 PE=2 SV=1 CANONICAL=Q9N181-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 38, "end_pos": 38, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9N181", "url": "https://www.uniprot.org/uniprotkb/Q9N181" } ], "site_lbl": "Ser38" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:282049", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282049", "resource": "KEGG Pathway" }, { "id": "R-BTA-2514859", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2514859", "resource": "Reactome", "description": "Inactivation, recovery and regulation of the phototransduction cascade" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZLL5-1", "protein_name": "Glycylpeptide N-tetradecanoyltransferase", "gene_name": "Nmt2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGDLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQSSKHNAIWQQISAGAAMGGDTMEGEWIDLRMYHKNPTIPIQKLQDIQRAMELLSACQGPARNIDEATKRRYQFWDTQPVPKLNEVITSHGAIEPDKDNIRQEPYSLPQGFMWDTLDLSNAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKRMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIRAVRELINVYLKQFHLAPVMGDEEVAHWFLPREHIIDTFVVESPSGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMNDALIIAKLKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVLQ", "length": 529 }, "evidence": [ { "id": "Q9N181", "url": "https://omabrowser.org/oma/group/Q9N181/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A7YT82-1", "protein_name": "Glycylpeptide N-tetradecanoyltransferase 2", "gene_name": "nmt2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAEDSESAASQQSLELDDQDTCGIDGDNEEENEHMQGSPGGDLGAKKKKKKQKRKKEKPSSGGTKSDSASDSQEIKNPAIPMQKLQDIQRAMELLSTCQGPAKNIDEATKHKYQFWDTQPVPKLNEVVTTHGPIEPDKENIRQEPYSLPQGFMWDTLDLSNAEVLKELYTLLNENYVEDDDNMFRFDYSPNFLKWALRPPGWLPHWHCGVRVSSNKKLVGFISAIPADIHIYDTLKRMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVSTCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDSTRTPGLRTMGDRDVKQVTALLQKHLSQFHLRPVMGEEEVKHWFLPQENIIDTFVVEGSGGMLTDFISFYTLPSTVMHHPLHKSLKAAYSFYNVHTETPLIDLMNDALILAKLKGFDVFNALDLMDNKNFLEKLKFGIGDGNLQYYLYNWKCPPMDPEKVGLVLQ", "length": 492 }, "evidence": [ { "id": "Q9N181", "url": "https://omabrowser.org/oma/group/Q9N181/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O60551-1", "protein_name": "Glycylpeptide N-tetradecanoyltransferase 2", "gene_name": "NMT2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQPSKNPSVPMQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVLQ", "length": 498 }, "evidence": [ { "id": "Q9N181", "url": "https://omabrowser.org/oma/group/Q9N181/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O70311-1", "protein_name": "Glycylpeptide N-tetradecanoyltransferase 2", "gene_name": "Nmt2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGDLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQSSKHNAIWQQISAGAAMGGDTMEGEWIDLRMYHKNPTIPIQKLQDIQRAMELLSACQGPARNIDEATKRRYQFWDTQPVPKLNEVITSHGAIEPDKDNIRQEPYSLPQGFMWDTLDLSNAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKRMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKAVRELINIYLKQFHLAPVMDDAEVAHWFLPREHIIDTFVVENPSGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMNDALIIAKLKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVLQ", "length": 529 }, "evidence": [ { "id": "Q9N181", "url": "https://omabrowser.org/oma/group/Q9N181/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "N-terminal peptidyl-glycine N-myristoylation", "id": "GO:0018008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018008", "evidence": [ { "database": "UniProtKB", "id": "Q9N181", "url": "https://www.uniprot.org/uniprotkb/Q9N181" } ], "pmid": "" }, { "name": "protein localization to membrane", "id": "GO:0072657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072657", "evidence": [ { "database": "UniProtKB", "id": "Q9N181", "url": "https://www.uniprot.org/uniprotkb/Q9N181" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9N181", "url": "https://www.uniprot.org/uniprotkb/Q9N181" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q9N181", "url": "https://www.uniprot.org/uniprotkb/Q9N181" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q9N181", "url": "https://www.uniprot.org/uniprotkb/Q9N181" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9N181", "url": "https://www.uniprot.org/uniprotkb/Q9N181" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "glycylpeptide N-tetradecanoyltransferase activity", "id": "GO:0004379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004379", "evidence": [ { "database": "UniProtKB", "id": "Q9N181", "url": "https://www.uniprot.org/uniprotkb/Q9N181" } ], "pmid": "" }, { "name": "peptidyl-lysine N6-myristoyltransferase activity", "id": "GO:0018030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018030", "evidence": [ { "database": "UniProtKB", "id": "Q9N181", "url": "https://www.uniprot.org/uniprotkb/Q9N181" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 391, "end_pos": 393, "annotation": "n_glycosylation_sequon" }, { "start_pos": 460, "end_pos": 462, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15521", "name": "", "equation": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9N181-1", "P31717-1", "F1MZK0-1" ], "evidence": [ { "id": "15521", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15521" } ] }, { "id": "70671", "name": "", "equation": "N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein] + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9N181-1" ], "evidence": [ { "id": "70671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70671" } ] }, { "id": "R-BTA-2534087", "name": "NMT1/2 transfer MYS to GNAT1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, photoreceptor disc membrane", "input_participant_list": [ "R-ALL-184174", "R-BTA-2534043" ], "output_participant_list": [ "R-BTA-2534062" ], "enzyme_list": [ "P04695-1", "F1MZK0-1", "Q9N181-1" ], "evidence": [ { "id": "R-BTA-2534087", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2534087" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-184174", "participant_name": "MYS-CoA [cytosol]", "crossref": [ { "id": "57385", "database": "ChEBI", "url": "" }, { "id": "ZINC000195445287", "database": "ZINC", "url": "" }, { "id": "C02593", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-BTA-2534043", "participant_name": "GNAT1 (Met removed) [cytosol]", "crossref": [ { "id": "P04695", "database": "UniProt", "url": "" }, { "id": "1AQG", "database": "PDB", "url": "" }, { "id": "8XGR", "database": "PDB", "url": "" }, { "id": "2X72", "database": "PDB", "url": "" }, { "id": "1FQK", "database": "PDB", "url": "" }, { "id": "6OY9", "database": "PDB", "url": "" }, { "id": "7JSN", "database": "PDB", "url": "" }, { "id": "4J4Q", "database": "PDB", "url": "" }, { "id": "3DQB", "database": "PDB", "url": "" }, { "id": "3PQR", "database": "PDB", "url": "" }, { "id": "1LVZ", "database": "PDB", "url": "" }, { "id": "3V00", "database": "PDB", "url": "" }, { "id": "6OYA", "database": "PDB", "url": "" }, { "id": "1GOT", "database": "PDB", "url": "" }, { "id": "1TND", "database": "PDB", "url": "" }, { "id": "1TAG", "database": "PDB", "url": "" }, { "id": "1FQJ", "database": "PDB", "url": "" }, { "id": "4BEY", "database": "PDB", "url": "" }, { "id": "1TAD", "database": "PDB", "url": "" }, { "id": "NP_851365.1", "database": "RefSeq", "url": "" }, { "id": "29454", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-2534062", "participant_name": "N-(C14:0)-GNAT1 [photoreceptor disc membrane]", "crossref": [ { "id": "6OY9", "database": "PDB", "url": "" }, { "id": "1GOT", "database": "PDB", "url": "" }, { "id": "4BEY", "database": "PDB", "url": "" }, { "id": "1AQG", "database": "PDB", "url": "" }, { "id": "3PQR", "database": "PDB", "url": "" }, { "id": "NP_851365.1", "database": "RefSeq", "url": "" }, { "id": "4J4Q", "database": "PDB", "url": "" }, { "id": "1TAG", "database": "PDB", "url": "" }, { "id": "2X72", "database": "PDB", "url": "" }, { "id": "3V00", "database": "PDB", "url": "" }, { "id": "29454", "database": "VGNC", "url": "" }, { "id": "7JSN", "database": "PDB", "url": "" }, { "id": "1TND", "database": "PDB", "url": "" }, { "id": "8XGR", "database": "PDB", "url": "" }, { "id": "1TAD", "database": "PDB", "url": "" }, { "id": "1LVZ", "database": "PDB", "url": "" }, { "id": "P04695", "database": "UniProt", "url": "" }, { "id": "3DQB", "database": "PDB", "url": "" }, { "id": "1FQJ", "database": "PDB", "url": "" }, { "id": "6OYA", "database": "PDB", "url": "" }, { "id": "1FQK", "database": "PDB", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F1MZK0", "gene_name": "NMT1", "activity": [ { "ec_number": "2.3.1.97", "activity": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+).", "evidence": [ { "id": "F1MZK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZK0" } ] }, { "ec_number": "2.3.1.97", "activity": "", "evidence": [ { "id": "F1MZK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MZK0" } ] } ] }, { "uniprot_ac": "P04695", "gene_name": "GNAT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P04695", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04695" } ] } ] }, { "uniprot_ac": "P31717", "gene_name": "NMT1", "activity": [ { "ec_number": "2.3.1.97", "activity": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+).", "evidence": [ { "id": "P31717", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P31717" } ] }, { "ec_number": "2.3.1.97", "activity": "", "evidence": [ { "id": "P31717", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P31717" } ] } ] }, { "uniprot_ac": "Q9N181", "gene_name": "NMT2", "activity": [ { "ec_number": "2.3.1.97", "activity": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+).", "evidence": [ { "id": "Q9N181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N181" } ] }, { "ec_number": "2.3.1.97", "activity": "", "evidence": [ { "id": "Q9N181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N181" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9N181-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 498, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9N181-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9N181" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.1.97", "ec_name": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+).", "evidence": [ { "id": "2.3.1.97", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.97" }, { "id": "2.3.1.97", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.1.97" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 38 ], "sequon_annotation_sites": [ { "start_pos": 319, "end_pos": 321 }, { "start_pos": 391, "end_pos": 393 }, { "start_pos": 460, "end_pos": 462 }, { "start_pos": 83, "end_pos": 85 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LZJ1-1", "uniprot_ac": "A0A3Q1LZJ1", "uniprot_id": "A0A3Q1LZJ1_BOVIN", "mass": { "chemical_mass": 50984.0, "monoisotopic_mass": 50984.0 }, "refseq": { "ac": "XP_005228537", "name": "glycogenin-2 isoform X8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228537" }, "gene_names": [ { "name": "GYG2", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ1" } ] }, { "name": "GYG2", "type": "synonym", "evidence": [ { "id": "XP_005228537", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228537" } ] } ], "protein_names": [ { "name": "glycogenin glucosyltransferase", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ1/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.186", "type": "synonym", "evidence": [ { "id": "A0A3Q1LZJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ1/entry#names_and_taxonomy" } ] }, { "name": "glycogenin-2 isoform X8", "type": "synonym", "evidence": [ { "id": "XP_005228537", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228537" } ] } ], "function": [ { "annotation": "Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9STA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA9#function" }, { "database": "UniProtKB", "id": "ARBA00049637", "url": "https://www.uniprot.org/uniprotkb/ARBA00049637#function" }, { "database": "UniProtKB", "id": "A0AAA9T9L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9L5#function" }, { "database": "UniProtKB", "id": "F1MSM4", "url": "https://www.uniprot.org/uniprotkb/F1MSM4#function" }, { "database": "UniProtKB", "id": "A0A3Q1LS23", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS23#function" }, { "database": "UniProtKB", "id": "A0A3Q1LZJ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZJ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GYG2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ1", "locus": { "chromosome": "X", "start_pos": 138690045, "end_pos": 138714386, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013341", "url": "https://www.ensembl.org/id/ENSBTAG00000013341" } ] } } ], "crossref": [ { "id": "A0A3Q1LZJ1", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LZJ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013341", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013341", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02537", "url": 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"A0A3Q1LZJ1", "url": "https://www.orthodb.org/?gene=A0A3Q1LZJ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MSM4", "url": "https://www.orthodb.org/?gene=F1MSM4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11183", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11183", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3322077", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3322077", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70221", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005228537", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228537", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "23360", "url": "https://www.rhea-db.org/rhea/23360", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "56560", "url": "https://www.rhea-db.org/rhea/56560", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LS23", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LS23-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS23-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZJ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9L5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9L5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSM4", "url": "https://www.uniprot.org/uniprotkb/F1MSM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSM4-1", "url": "https://www.uniprot.org/uniprotkb/F1MSM4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVSDQAFVTLATNDVYCQGALVLGQSLREHRATRRLVVLVTPQVSNPLRVILSRVFDEVIEVNLIDSADYVHLAFLKRPDLGITLTKLHCWTLTRYSKCVFLDADTLVLSNIDELFDRREFSAAPDPGWPDCFNSGVFVFQPSLETHSLLLQHATDHGSFDGADQGLLNSFFSNWSTADIQKHLPFIYNLSSNTTYTYSPAFKQFGSSAKVVHFLGSSKPWNCKYNPQTGSVLEEGSGRADQHQTSFLNQWWGIYHRSILPLCEDIRNKDHHAPPGHTAHLGGAGVPCSSAAAAAEGSCANPAEGPRQACSADASERIMGVEEDIPTRAACPSEETVGWREIETRAEVRRNVFSAPSPQFADLSEIQTSSRRAEKAGGAPPEDALEPSREPPADVSRDPSPQDALEVDLTISVSQISIEEKLKVLSPEEERRKWEEGRMDYLGKDAFARIQEKLDRFLQ", "length": 460, "header": "tr|A0A3Q1LZJ1-1|A0A3Q1LZJ1_BOVIN Isoform 1 of glycogenin glucosyltransferase OS=Bos taurus OX=9913 GN=GYG2 PE=3 SV=3 CANONICAL=A0A3Q1LZJ1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LS23-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS23/entry", "sequence": { "sequence": "RGEGPEGAGRGVRGARLQALPSRGPQPGHQARRAAGAGRAGDPRPGAELTVWRAAHLWAARRPAHPGQQLRERGEVSDQAFVTLATNDVYCQGALVLGQSLREHRATRRLVVLVTPQVSNPLRVILSRVFDEVIEVNLIDSADYVHLAFLKRPDLGITLTKLHCWTLTRYSKCVFLDADTLVLSNIDELFDRREFSAAPDPGWPDCFNSGVFVFQPSLETHSLLLQHATDHGSFDGADQGLLNSFFSNWSTADIQKHLPFIYNLSSNTTYTYSPAFKQFGSSAKVVHFLGSSKPWNCKYNPQTGSVLEEGSGRADQHQTSFLNQWWGIYHRSILPLCEDIRNKDHHAPPGHTAHLGGAGVPCSSAAAAAEGSCANPAEGPRQACSADASERIMGVEEDIPTRAACPSEETVGWREIETRAEVRRNVFSAPSPQFADLSEIQTSSRRAEKAGGAPPEDALEPSREPPADVSRDPSPQDALEVVSPVPTVHLVQLP", "length": 494, "header": "tr|A0A3Q1LS23-1|A0A3Q1LZJ1_BOVIN Computationally mapped isoform of glycogenin glucosyltransferase OS=Bos taurus OX=9913 GN=GYG2 PE=3 SV=2 CANONICAL=A0A3Q1LZJ1-1" }, "locus": { "chromosome": "Y", "start_pos": 1411645, "end_pos": 1389475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083061.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083061.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057884.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057884.2" } ] } }, { "isoform_ac": "A0A3Q1LZJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ1/entry", "sequence": { "sequence": "MPVSDQAFVTLATNDVYCQGALVLGQSLREHRATRRLVVLVTPQVSNPLRVILSRVFDEVIEVNLIDSADYVHLAFLKRPDLGITLTKLHCWTLTRYSKCVFLDADTLVLSNIDELFDRREFSAAPDPGWPDCFNSGVFVFQPSLETHSLLLQHATDHGSFDGADQGLLNSFFSNWSTADIQKHLPFIYNLSSNTTYTYSPAFKQFGSSAKVVHFLGSSKPWNCKYNPQTGSVLEEGSGRADQHQTSFLNQWWGIYHRSILPLCEDIRNKDHHAPPGHTAHLGGAGVPCSSAAAAAEGSCANPAEGPRQACSADASERIMGVEEDIPTRAACPSEETVGWREIETRAEVRRNVFSAPSPQFADLSEIQTSSRRAEKAGGAPPEDALEPSREPPADVSRDPSPQDALEVDLTISVSQISIEEKLKVLSPEEERRKWEEGRMDYLGKDAFARIQEKLDRFLQ", "length": 460, "header": "tr|A0A3Q1LZJ1-1|A0A3Q1LZJ1_BOVIN Isoform 1 of glycogenin glucosyltransferase OS=Bos taurus OX=9913 GN=GYG2 PE=3 SV=3 CANONICAL=A0A3Q1LZJ1-1" }, "locus": { "chromosome": "Y", "start_pos": 1412876, "end_pos": 1390399, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085404.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085404.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061126.3", "url": "https://www.ensembl.org/id/ENSBTAP00000061126.3" } ] } }, { "isoform_ac": "A0AAA9STA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STA9/entry", "sequence": { "sequence": "MGALNSERVGPLETQPTPPLGWAAGARERGSPPRLGALGHVVPIARCAHTMPVSDQAFVTLATNDVYCQGALVLGQSLREHRATRRLVVLVTPQVSNPLRVILSRVFDEVIEVNLIDSADYVHLAFLKRPDLGITLTKLHCWTLTRYSKCVFLDADTLVLSNIDELFDRREFSAAPDPGWPDCFNSGVFVFQPSLETHSLLLQHATDHGSFDGADQGLLNSFFSNWSTADIQKHLPFIYNLSSNTTYTYSPAFKQFGSSAKVVHFLGSSKPWNCKYNPQTGSVLEEGSGRADQHQTSFLNQWWGIYHRSILPLCEDIRNKDHHAPPGHTAHLGGAGVPCSSAAAAAEGSCANPAEGPRQACSADASERIMGVEEDIPTRAACPSEETVGWREIETRAEVRRNVFSAPSPQFADLSEIQTSSVDLTISVSQISIEEKLKVLSPEEERRKWEEGRMDYLGKDAFARIQEKLDRFLQ", "length": 474, "header": "tr|A0AAA9STA9-1|A0A3Q1LZJ1_BOVIN Computationally mapped isoform of glycogenin glucosyltransferase OS=Bos taurus OX=9913 GN=GYG2 PE=3 SV=2 CANONICAL=A0A3Q1LZJ1-1" }, "locus": { "chromosome": "Y", "start_pos": 1412876, "end_pos": 1390060, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131308.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131308.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089658.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089658.2" } ] } }, { "isoform_ac": "A0AAA9T9L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9L5/entry", "sequence": { "sequence": "HTFPPYDHVSSVASAPGRALAWGPEASANIDFGGGVLKVRGFRARTPQTPGFRGEGPEGAGRGVRGARLQALPSEGPQPGHQARRAAGAGRAGDPRPGAELTVWRAAHLWAARRPAHPGQQLRERGEVSDQAFVTLATNDVYCQGALVLGQSLREHRATRRLVVLVTPQVSNPLRVILSRVFDEVIEVNLIDSADYVHLAFLKRPDLGITLTKLHCWTLTRYSKCVFLDADTLVLSNIDELFDRREFSAAPDPGWPDCFNSGVFVFQPSLETHSLLLQHATDHGSFDGADQGLLNSFFSNWSTADIQKHLPFIYNLSSNTTYTYSPAFKQFGSSAKVVHFLGSSKPWNCKYNPQTGSVLEEGSGRADQHHTSFLNQWWGIYHRSILPLCEDIRNKDHHAPPGHTAHLGGAGVPCSSAAAAAEGSCANPAEGPRQACSADASERIMGVEEDIPTRAACPSEETVGWREIETRAEVRRNVFSAPSPQFADLSEIQTSSRRAEKAGGAPPEDALEPSREPPADVSRDPSPQDALEVVSPVPTVHLVQLP", "length": 546, "header": "tr|A0AAA9T9L5-1|A0A3Q1LZJ1_BOVIN Computationally mapped isoform of glycogenin glucosyltransferase OS=Bos taurus OX=9913 GN=GYG2 PE=3 SV=2 CANONICAL=A0A3Q1LZJ1-1" }, "locus": { "chromosome": "X", "start_pos": 138714388, "end_pos": 138692280, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106696.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106696.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094690.2", "url": "https://www.ensembl.org/id/ENSBTAP00000094690.2" } ] } }, { "isoform_ac": "F1MSM4-1", "url": "https://www.uniprot.org/uniprotkb/F1MSM4/entry", "sequence": { "sequence": "MPVSDQAFVTLATNDVYCQGALVLGQSLREHRATRRLVVLVTPQVSNPLRVILSRVFDEVIEVNLIDSADYVHLAFLKRPDLGITLTKLHCWTLTRYSKCVFLDADTLVLSNIDELFDRREFSAAPDPGWPDCFNSGVFVFQPSLETHSLLLQHATDHGSFDGADQGLLNSFFSNWSTADIQKHLPFIYNLSSNTTYTYSPAFKQFGSSAKVVHFLGSSKPWNCKYNPQTGSVLEEGSGRADQHHTSFLNQWWGIYHRSILPLCEDIRNKDHHAPPGHTAHLGGAGVPCSSAAAAAEGSCANPAEGPRQACSADASERIMGVEEDIPTRAACPSEETVGWREIETRAEVRRNVFSAPSPQFADLSEIQTSSRRAEKAGGAPPEDALEPSREPPADVSRDPSPQDALEVGLTISVSQISIEEKLKVLSPEEERRKWEEGRMDYLGKDAFARIQEKLDRFLQ", "length": 460, "header": "tr|F1MSM4-1|F1MSM4_BOVIN Computationally mapped isoform of glycogenin glucosyltransferase OS=Bos taurus OX=9913 GN=GYG2 PE=3 SV=5 CANONICAL=A0A3Q1LZJ1-1" }, "locus": { "chromosome": "X", "start_pos": 138713308, "end_pos": 138691049, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017744.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017744.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017744.8", "url": "https://www.ensembl.org/id/ENSBTAP00000017744.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-3322077", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3322077", "resource": "Reactome", "description": "Glycogen synthesis" }, { "id": "R-BTA-70221", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70221", "resource": "Reactome", "description": "Glycogen breakdown (glycogenolysis)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glycogenin glucosyltransferase activity", "id": "GO:0008466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008466", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZJ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "glycogen biosynthetic process", "id": "GO:0005978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005978", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZJ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZJ1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23360", "name": "", "equation": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LZJ1-1", "A0A3Q1M6X0-1" ], "evidence": [ { "id": "23360", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23360" } ] }, { "id": "56560", "name": "", "equation": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LZJ1-1", "A0A3Q1M6X0-1" ], "evidence": [ { "id": "56560", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/56560" } ] }, { "id": "R-BTA-3322009", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B9X7-1", "A0A3Q1LZJ1-1" ], "evidence": [ { "id": "R-BTA-3322009", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3322009" } ] }, { "id": "R-BTA-3322014", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B9X7-1", "A0A3Q1LZJ1-1" ], "evidence": [ { "id": "R-BTA-3322014", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3322014" } ] }, { "id": "R-BTA-3322016", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B9X7-1", "A0A3Q1MPG8-1", "A0A3Q1LZJ1-1" ], "evidence": [ { "id": "R-BTA-3322016", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3322016" } ] }, { "id": "R-BTA-3322019", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B9X7-1", "A0A3Q1LZJ1-1" ], "evidence": [ { "id": "R-BTA-3322019", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3322019" } ] }, { "id": "R-BTA-3780994", "name": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B9X7-1", "A0A3Q1LZJ1-1" ], "evidence": [ { "id": "R-BTA-3780994", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3780994" } ] }, { "id": "R-BTA-3780997", "name": "PPP1R3C binds to glycogen:GYG2:GYS2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B9X7-1", "A0A3Q1LZJ1-1" ], "evidence": [ { "id": "R-BTA-3780997", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3780997" } ] }, { "id": "R-BTA-3781011", "name": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1B9X7-1", "A0A3Q1LZJ1-1" ], "evidence": [ { "id": "R-BTA-3781011", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3781011" } ] }, { "id": "R-BTA-453339", "name": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VCM4-1", "A0A3Q1LZJ1-1" ], "evidence": [ { "id": "R-BTA-453339", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-453339" } ] }, { "id": "R-BTA-71552", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHT1-1", "A0A3Q1LZJ1-1" ], "evidence": [ { "id": "R-BTA-71552", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71552" } ] }, { "id": "R-BTA-71590", "name": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0VCM4-1", "A0A3Q1LZJ1-1" ], "evidence": [ { "id": "R-BTA-71590", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71590" } ] }, { "id": "R-BTA-71593", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHT1-1", "A0A3Q1LZJ1-1" ], "evidence": [ { "id": "R-BTA-71593", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71593" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LZJ1", "gene_name": "GYG2", "activity": [ { "ec_number": "2.4.1.186", "activity": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+).", "evidence": [ { "id": "A0A3Q1LZJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ1" } ] }, { "ec_number": "2.4.1.186", "activity": "", "evidence": [ { "id": "A0A3Q1LZJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZJ1" } ] } ] }, { "uniprot_ac": "A0A3Q1M6X0", "gene_name": "GYG1", "activity": [ { "ec_number": "2.4.1.186", "activity": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+).", "evidence": [ { "id": "A0A3Q1M6X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6X0" } ] }, { "ec_number": "2.4.1.186", "activity": "", "evidence": [ { "id": "A0A3Q1M6X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6X0" } ] } ] }, { "uniprot_ac": "A0A3Q1MPG8", "gene_name": "GBE1", "activity": [ { "ec_number": "2.4.1.18", "activity": "Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.", "evidence": [ { "id": "A0A3Q1MPG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPG8" } ] }, { "ec_number": "2.4.1.18", "activity": "", "evidence": [ { "id": "A0A3Q1MPG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MPG8" } ] } ] }, { "uniprot_ac": "E1B9X7", "gene_name": "GYS2", "activity": [ { "ec_number": "2.4.1.11", "activity": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + UDP + H(+).", "evidence": [ { "id": "E1B9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9X7" } ] }, { "ec_number": "2.4.1.11", "activity": "", "evidence": [ { "id": "E1B9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9X7" } ] } ] }, { "uniprot_ac": "F1MHT1", "gene_name": "AGL", "activity": [ { "ec_number": "2.4.1.25", "activity": "Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "3.2.1.33", "activity": "Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "3.2.1.33", "activity": "", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] }, { "ec_number": "2.4.1.25", "activity": "", "evidence": [ { "id": "F1MHT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT1" } ] } ] }, { "uniprot_ac": "Q0VCM4", "gene_name": "PYGL", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "Q0VCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCM4" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "Q0VCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCM4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.4.1.186", "ec_name": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+).", "evidence": [ { "id": "2.4.1.186", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186" }, { "id": "2.4.1.186", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.1.186" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 175, "end_pos": 177 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 194, "end_pos": 196 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPA5-1", "uniprot_ac": "E1BPA5", "uniprot_id": "E1BPA5_BOVIN", "mass": { "chemical_mass": 30305.0, "monoisotopic_mass": 30305.0 }, "refseq": { "ac": "NP_001192908", "name": "probable palmitoyltransferase ZDHHC24", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192908" }, "gene_names": [ { "name": "ZDHHC24", "type": "recommended", "evidence": [ { "id": "E1BPA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA5" } ] }, { "name": "ZDHHC24", "type": "synonym", "evidence": [ { "id": "NP_001192908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192908" } ] } ], "protein_names": [ { "name": "Palmitoyltransferase", "type": "recommended", "evidence": [ { "id": "E1BPA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA5/entry#names_and_taxonomy" } ] }, { "name": "2.3.1.225", "type": "synonym", "evidence": [ { "id": "E1BPA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA5/entry#names_and_taxonomy" } ] }, { "name": "probable palmitoyltransferase ZDHHC24", "type": "synonym", "evidence": [ { "id": "NP_001192908", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192908" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPA5", "url": "https://www.uniprot.org/uniprotkb/E1BPA5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZDHHC24", "url": "https://www.uniprot.org/uniprotkb/E1BPA5", "locus": { "chromosome": "29", "start_pos": 44576984, "end_pos": 44584260, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005756", "url": "https://www.ensembl.org/id/ENSBTAG00000005756" } ] } } ], "crossref": [ { "id": "E1BPA5", "url": "https://alphafold.ebi.ac.uk/entry/E1BPA5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005756", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005756", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "530442", "url": "https://www.ncbi.nlm.nih.gov/gene/530442", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530442", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530442", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RMHLTWL", "url": "https://omabrowser.org/oma/group/RMHLTWL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPA5", "url": "https://www.orthodb.org/?gene=E1BPA5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22883", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22883", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22883:SF414", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22883:SF414", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01529", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01529", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192908", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "36683", "url": "https://www.rhea-db.org/rhea/36683", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SZ21", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPA5", "url": "https://www.uniprot.org/uniprotkb/E1BPA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPA5-1", "url": "https://www.uniprot.org/uniprotkb/E1BPA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGQPWAVGTAEASPARLPLVLTALWAAAVGLELAYVLVLGPGPPPLGPLARTLQVALAAFQLLNLLGNVGLFLRSDPSIRGVMLAGRGLGQGWAYCYQCQSQVPPRSGHCSACRICILRRDHHCRLLGRCVGFRNYRPFLCLLLHGAGVLLHASVLLGPALSALLRAHTPLHTAALLLLPWLMLLTGRVSLAQFALAFVTDTCVAGALLCGAGLLFHGMLLLRGQTTWEWARGQHAYDLGPCHNLQAALGPRWVLVWLWPFLASPLPGDGITFQTAADVGLMAS", "length": 284, "header": "tr|E1BPA5-1|E1BPA5_BOVIN Isoform 1 of Palmitoyltransferase OS=Bos taurus OX=9913 GN=ZDHHC24 PE=3 SV=1 CANONICAL=E1BPA5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZ21-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ21/entry", "sequence": { "sequence": "MGQPWAVGTAEASPARLPLVLTALWAAAVGLELAYVLVLGPGPPPLGPLARTLQVALAAFQLLNLLGNVGLFLRSDPSIRGVMLAGRGLGQGWAYCYQCQSQVPPRSGHCSACRICILRRDHHCRLLGRCVGFRNYRPFLCLLLHGAGVLLHASVLLGPALSALLRAHTPLHTAALLLLPWLMLLTVTEDSPAPSLSQPWALLSASASESLGRVSLAQFALAFVTDTCVAGALLCGAGLLFHGMLLLRGQTTWEWARGQHAYDLGPCHNLQAALGPRWVLVWLWPFLASPLPGDGITFQTAADVGLMAS", "length": 309, "header": "tr|A0AAA9SZ21-1|E1BPA5_BOVIN Computationally mapped isoform of Palmitoyltransferase OS=Bos taurus OX=9913 GN=ZDHHC24 PE=3 SV=1 CANONICAL=E1BPA5-1" }, "locus": { "chromosome": "29", "start_pos": 44584061, "end_pos": 44577988, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116433.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116433.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091712.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091712.1" } ] } }, { "isoform_ac": "E1BPA5-1", "url": "https://www.uniprot.org/uniprotkb/E1BPA5/entry", "sequence": { "sequence": "MGQPWAVGTAEASPARLPLVLTALWAAAVGLELAYVLVLGPGPPPLGPLARTLQVALAAFQLLNLLGNVGLFLRSDPSIRGVMLAGRGLGQGWAYCYQCQSQVPPRSGHCSACRICILRRDHHCRLLGRCVGFRNYRPFLCLLLHGAGVLLHASVLLGPALSALLRAHTPLHTAALLLLPWLMLLTGRVSLAQFALAFVTDTCVAGALLCGAGLLFHGMLLLRGQTTWEWARGQHAYDLGPCHNLQAALGPRWVLVWLWPFLASPLPGDGITFQTAADVGLMAS", "length": 284, "header": "tr|E1BPA5-1|E1BPA5_BOVIN Isoform 1 of Palmitoyltransferase OS=Bos taurus OX=9913 GN=ZDHHC24 PE=3 SV=1 CANONICAL=E1BPA5-1" }, "locus": { "chromosome": "29", "start_pos": 44584061, "end_pos": 44577988, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000007564.3", "url": "https://www.ensembl.org/id/ENSBTAT00000007564.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000007564.1", "url": "https://www.ensembl.org/id/ENSBTAP00000007564.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:530442", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530442", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1QGD2-1", "protein_name": "Probable palmitoyltransferase ZDHHC24", "gene_name": "zdhhc24", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTSFMSRVWCKVESTGRQLPIVLNAVLVFSITAEVSYLVLVEAPFEPEQKKTDWSTIWTGLHLFAQYFMLGNITWNASLFVKTNPSIRGVFLGGDTLGQGWRYCYNCETHTPPRCSHCYDCNVCVLRRDHHCVFFGQCVGFHNYRYFLTCLLFMWAGLLYAVVMNAEVFIFILKEGVTFHSVMLLLVPWIMLVSGQVTTRAFAFAFIADTCVVGFLLVAAFLFFHVALMLRGQTTREWYSTRRPYSLGTMANIRECLGKNWYFCWLCPLIPSPLPGDGINFKVTASLEPKKQAVH", "length": 295 }, "evidence": [ { "id": "E1BPA5", "url": "https://omabrowser.org/oma/group/E1BPA5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6IR37-1", "protein_name": "Probable palmitoyltransferase ZDHHC24", "gene_name": "Zdhhc24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGESWAARGAEGAPARMPLVLTALWAAVVVLELAYVMVLGPGPPPLGPLARALQLALAAYQLLNLLGNVVLFLRSDPSIRGVMLAGRGLGQGWAYCYQCQSQVPPRSGHCSACRVCILRRDHHCRLLGCCVGFHNYRPFLCLLLHSAGVLLHISVLLGPALSALLQAHSALYTVALLLLPWLMLLTGKVSLAQFALAFVVDTCVAGALLCGAGLLFHGMLLLRGQTTWEWARGHHCYDLGTCHNLQAALGPRWALVWFWPFLASPLPGDGISFQTPGDVGLVTS", "length": 284 }, "evidence": [ { "id": "E1BPA5", "url": "https://omabrowser.org/oma/group/E1BPA5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6UX98-1", "protein_name": "Probable palmitoyltransferase ZDHHC24", "gene_name": "ZDHHC24", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQPWAAGSTDGAPAQLPLVLTALWAAAVGLELAYVLVLGPGPPPLGPLARALQLALAAFQLLNLLGNVGLFLRSDPSIRGVMLAGRGLGQGWAYCYQCQSQVPPRSGHCSACRVCILRRDHHCRLLGRCVGFGNYRPFLCLLLHAAGVLLHVSVLLGPALSALLRAHTPLHMAALLLLPWLMLLTGRVSLAQFALAFVTDTCVAGALLCGAGLLFHGMLLLRGQTTWEWARGQHSYDLGPCHNLQAALGPRWALVWLWPFLASPLPGDGITFQTTADVGHTAS", "length": 284 }, "evidence": [ { "id": "E1BPA5", "url": "https://omabrowser.org/oma/group/E1BPA5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BPA5", "url": "https://www.uniprot.org/uniprotkb/E1BPA5" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1BPA5", "url": "https://www.uniprot.org/uniprotkb/E1BPA5" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1BPA5", "url": "https://www.uniprot.org/uniprotkb/E1BPA5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-cysteine S-palmitoyltransferase activity", "id": "GO:0019706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019706", "evidence": [ { "database": "UniProtKB", "id": "E1BPA5", "url": "https://www.uniprot.org/uniprotkb/E1BPA5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein targeting to membrane", "id": "GO:0006612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006612", "evidence": [ { "database": "UniProtKB", "id": "E1BPA5", "url": "https://www.uniprot.org/uniprotkb/E1BPA5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36683", "name": "", "equation": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3X756-1", "E1BPA5-1", "F1MVC6-1", "E1B987-1", "E1BJK1-1", "F6R785-1", "A0AAA9TDW4-1", "A0AAA9TVJ9-1", "A0AAA9TM40-1", "E1B6X9-1", "E1BKA0-1", "E1BK60-1", "Q58CU4-1", "A2VDT6-1", "A0AAF6ZH94-1", "A0AAA9RZ07-1", "Q0VC89-1", "E1BLT8-1", "G3MXF3-1", "P15103-1", "Q2HJ95-1", "Q58DA8-1", "A0A3Q1M794-1", "A0A3Q1LVW6-1", "Q58DT3-1", "A0A3Q1M403-1", "A0ABI0NXA5-1" ], "evidence": [ { "id": "36683", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36683" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LVW6", "gene_name": "ZDHHC13", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1LVW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1LVW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ] } ] }, { "uniprot_ac": "A0A3Q1M403", "gene_name": "", "activity": [ { "ec_number": "6.3.1.2", "activity": "L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "6.3.1.2", "activity": "", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] } ] }, { "uniprot_ac": "A0A3Q1M794", "gene_name": "ZDHHC3", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1M794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M794" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1M794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M794" } ] } ] }, { "uniprot_ac": "A0AAA9RZ07", "gene_name": "ZDHHC8", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9RZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ07" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9RZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ07" } ] } ] }, { "uniprot_ac": "A0AAA9TDW4", "gene_name": "ZDHHC7", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW4" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW4" } ] } ] }, { "uniprot_ac": "A0AAA9TM40", "gene_name": "ZDHHC18", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TM40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM40" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TM40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM40" } ] } ] }, { "uniprot_ac": "A0AAA9TVJ9", "gene_name": "ZDHHC23", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TVJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVJ9" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TVJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVJ9" } ] } ] }, { "uniprot_ac": "A0AAF6ZH94", "gene_name": "ZDHHC9", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAF6ZH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAF6ZH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ] } ] }, { "uniprot_ac": "A0ABI0NXA5", "gene_name": "ZDHHC15", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0ABI0NXA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXA5" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0ABI0NXA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXA5" } ] } ] }, { "uniprot_ac": "A2VDT6", "gene_name": "ZDHHC21", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A2VDT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT6" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A2VDT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT6" } ] } ] }, { "uniprot_ac": "E1B6X9", "gene_name": "ZDHHC12", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1B6X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X9" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1B6X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X9" } ] } ] }, { "uniprot_ac": "E1B987", "gene_name": "ZDHHC22", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1B987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B987" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1B987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B987" } ] } ] }, { "uniprot_ac": "E1BJK1", "gene_name": "ZDHHC17", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1BJK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJK1" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1BJK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJK1" } ] } ] }, { "uniprot_ac": "E1BK60", "gene_name": "ZDHHC14", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1BK60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK60" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1BK60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK60" } ] } ] }, { "uniprot_ac": "E1BKA0", "gene_name": "ZDHHC4", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1BKA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKA0" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1BKA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKA0" } ] } ] }, { "uniprot_ac": "E1BLT8", "gene_name": "ZDHHC5", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1BLT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLT8" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1BLT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLT8" } ] } ] }, { "uniprot_ac": "E1BPA5", "gene_name": "ZDHHC24", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1BPA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA5" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1BPA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA5" } ] } ] }, { "uniprot_ac": "F1MVC6", "gene_name": "", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "F1MVC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC6" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "F1MVC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVC6" } ] } ] }, { "uniprot_ac": "F6R785", "gene_name": "ZDHHC1", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "F6R785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R785" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "F6R785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R785" } ] } ] }, { "uniprot_ac": "G3MXF3", "gene_name": "ZDHHC2", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "G3MXF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXF3" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "G3MXF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXF3" } ] } ] }, { "uniprot_ac": "G3X756", "gene_name": "", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "G3X756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X756" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "G3X756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X756" } ] } ] }, { "uniprot_ac": "P15103", "gene_name": "GLUL", "activity": [ { "ec_number": "6.3.1.2", "activity": "L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+).", "evidence": [ { "id": "P15103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15103" } ] }, { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "P15103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15103" } ] }, { "ec_number": "6.3.1.2", "activity": "", "evidence": [ { "id": "P15103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15103" } ] } ] }, { "uniprot_ac": "Q0VC89", "gene_name": "ZDHHC20", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "Q0VC89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC89" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "Q0VC89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC89" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q0VC89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC89" } ] } ] }, { "uniprot_ac": "Q2HJ95", "gene_name": "ZDHHC6", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "Q2HJ95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ95" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "Q2HJ95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ95" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q2HJ95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ95" } ] } ] }, { "uniprot_ac": "Q58CU4", "gene_name": "ZDHHC16", "activity": [ { "ec_number": "2.3.1.225", "activity": 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"PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00036", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00036", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M0Q4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ39", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ39-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ39-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVY3", "database": 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taurus OX=9913 GN=CABP2 PE=2 SV=3 CANONICAL=Q9N1Q9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Q4/entry", "sequence": { "sequence": "MVQGPMGNCAKRPRHRAPKDRELRPEEIEELQAAFQEFDRDRDGYIGYQELGACMRTLGYMPTEMELIEISQQISGGKVDFEDFVELMGPKLLAETADMIGVRELRDAFREFDTNGDGCISLGELRAALKALLGERLSQREVDEILRDIDLNGDGLVDFEETGHGPPLPPGMIQSLCLALEGSMRMRNWHTVTHVRKKHQGDFS", "length": 204, "header": "tr|A0A3Q1M0Q4-1|CABP2_BOVIN Computationally mapped isoform of Calcium-binding protein 2 OS=Bos taurus OX=9913 GN=CABP2 PE=2 SV=2 CANONICAL=Q9N1Q9-1" }, "locus": { "chromosome": "29", "start_pos": 45401675, "end_pos": 45396064, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073959.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073959.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063238.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063238.2" } ] } }, { "isoform_ac": "A0A452DJ39-1", "url": 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"MFTAGPCLGPWDSPRDSRTGMVQGPMGNCAKRPRHRAPKDRWQWPGSPPGGSRHGLGPSPSPEEPGAPGPGVQGYSVLSSVVGPACIFLRPSIAATQLDRELRPEEIEELQAAFQEFDRDRDGYIGYQELGACMRTLGYMPTEMELIEISQQISGGKVDFEDFVELMGPKLLAETADMIGVRELRDAFREFDTNGDGCISLGELRAALKALLGERLSQREVDEILRDIDLNGDGLVDFEEFVRMMSR", "length": 247, "header": "tr|A0AAA9RVY3-1|CABP2_BOVIN Computationally mapped isoform of Calcium-binding protein 2 OS=Bos taurus OX=9913 GN=CABP2 PE=2 SV=1 CANONICAL=Q9N1Q9-1" }, "locus": { "chromosome": "29", "start_pos": 45403922, "end_pos": 45397209, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129207.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129207.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076521.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076521.1" } ] } }, { "isoform_ac": "A0AAA9S9G8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9G8/entry", "sequence": { "sequence": "MRKGLTPPCLAELQAAFQEFDRDRDGYIGYQELGACMRTLGYMPTEMELIEISQQISGGKVDFEDFVELMGPKLLAETADMIGVRELRDAFREFDTNGDGCISLGELRAALKALLGERLSQREVDEILRDIDLNGDGLVDFEEFVRMMSR", "length": 150, "header": "tr|A0AAA9S9G8-1|CABP2_BOVIN Computationally mapped isoform of Calcium-binding protein 2 OS=Bos taurus OX=9913 GN=CABP2 PE=2 SV=1 CANONICAL=Q9N1Q9-1" }, "locus": { "chromosome": "29", "start_pos": 45399568, "end_pos": 45397209, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118100.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118100.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080576.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080576.1" } ] } }, { "isoform_ac": "Q9N1Q9-1", "url": "https://www.uniprot.org/uniprotkb/Q9N1Q9/entry#Q9N1Q9-1", "sequence": { "sequence": "MGNCAKRPRHRAPKDRELRPEEIEELQAAFQEFDRDRDGYIGYQELGACMRTLGYMPTEMELIEISQQISGGKVDFEDFVELMGPKLLAETADMIGVRELRDAFREFDTNGDGCISLGELRAALKALLGERLSQREVDEILRDIDLNGDGLVDFEEFVRMMSR", "length": 163, "header": "sp|Q9N1Q9-1|CABP2_BOVIN Isoform 1 of Calcium-binding protein 2 OS=Bos taurus OX=9913 GN=CABP2 PE=2 SV=3 CANONICAL=Q9N1Q9-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin.", "journal": "J. Biol. Chem.", "date": "2000", "authors": "Haeseleer F, Sokal I, Verlinde C L, Erdjument-Bromage H, Tempst P, Pronin A N, Benovic J L, Fariss R N, Palczewski K", "evidence": [ { "database": "UniProtKB", "id": "Q9N1Q9", "url": "https://www.uniprot.org/uniprotkb/Q9N1Q9" } ], "reference": [ { "type": "PubMed", "id": "10625670", "url": "https://glygen.org/publication/PubMed/10625670" } ] } ], "pathway": [ { "id": "bta:281654", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281654", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q9N1Q9", "url": "https://www.uniprot.org/uniprotkb/Q9N1Q9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": 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Can also act on D-arabinose and L-galactose, with lower catalytic efficiency. Does not use NADPH. May be the initial enzyme of the putative L-fucose degradation pathway in mammals.", "evidence": [ { "database": "UniProtKB", "id": "Q9MYP6", "url": "https://www.uniprot.org/uniprotkb/Q9MYP6#function" }, { "database": "UniProtKB", "id": "Q9BPX1", "url": "https://www.uniprot.org/uniprotkb/Q9BPX1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9MYP6", "url": "https://www.uniprot.org/uniprotkb/Q9MYP6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HSD17B14", "url": "https://www.uniprot.org/uniprotkb/Q9MYP6", "locus": { "chromosome": "18", "start_pos": 55427042, "end_pos": 55447541, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009174", "url": "https://www.ensembl.org/id/ENSBTAG00000009174" } ] } } ], "crossref": [ { "id": "Q9MYP6", "url": "https://alphafold.ebi.ac.uk/entry/Q9MYP6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009174", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009174", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08933", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08933", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282652", "url": "https://www.ncbi.nlm.nih.gov/gene/282652", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9MYP6", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9MYP6*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282652", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282652", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AAYQMSQ", "url": "https://omabrowser.org/oma/group/AAYQMSQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MES8", "url": "https://www.orthodb.org/?gene=A0A3Q1MES8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q9MYP6", "url": "https://www.orthodb.org/?gene=Q9MYP6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43658", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43658", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43658:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43658:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-193144", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193144", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_777126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777126", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "81515", "url": "https://www.rhea-db.org/rhea/81515", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "81519", "url": "https://www.rhea-db.org/rhea/81519", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "81523", "url": "https://www.rhea-db.org/rhea/81523", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MES8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MES8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MES8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MES8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTC1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YTC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9MYP6", "url": "https://www.uniprot.org/uniprotkb/Q9MYP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9MYP6-1", "url": "https://www.uniprot.org/uniprotkb/Q9MYP6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMGTRYAGKVVIVTGGGRGIGAGIVRAFVESGAQVVICDKDEARGRAVERELPGTVFLLCDVTREEDVRTLVSETIRRFGRLDCIVNNAGYHPPPQWPEETSAQGFRQLLELNLLGTYTLTKLALPHLRKSRGNVINISSLVGAIGQSQAVPYVATKGAVTAMTKALALDESQYGVRVNCISPGNIWTPLWEELAASTPDPTATIREGTLAQPLGRMGQPAEVAAAAVFLASEATFCTGTELLVTGGAELGYGRKAGQAAPAEAPTTPS", "length": 270, "header": "sp|Q9MYP6-1|DHB14_BOVIN Isoform 1 of L-fucose dehydrogenase OS=Bos taurus OX=9913 GN=HSD17B14 PE=2 SV=1 CANONICAL=Q9MYP6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MES8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MES8/entry", "sequence": { "sequence": "MAMGTRYAGKVVIVTGGGRGIGAGIVRAFGEWGLAEARGRAVERELPGTVFLLCDVTREEDVRTLVSETIRRFGRLDCIVNNAGYHPPPQWPEETSAQGFRQLLELNLLGTYTLTKLALPHLRKSRGNVINISSLVGAIGQSQAVPYVATKGAVTAMTKALALDESQYGVRVNCISPGNIWTPLWEELAASTPDPTATIREGTLAQPLGRMGQPAEVAAAAVFLASEATFCTGTELLVTGGAELGYGRKAGQAAPAEAPTTPS", "length": 263, "header": "tr|A0A3Q1MES8-1|DHB14_BOVIN Computationally mapped isoform of L-fucose dehydrogenase OS=Bos taurus OX=9913 GN=HSD17B14 PE=2 SV=1 CANONICAL=Q9MYP6-1" }, "locus": { "chromosome": "18", "start_pos": 55447426, "end_pos": 55427237, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070108.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070108.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069563.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069563.1" } ] } }, { "isoform_ac": "A0AAF6YTC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YTC1/entry", "sequence": { "sequence": "MAMGTRYAGKVVIVTGGGRGIGAGIVRAFGEWVESGAQVVICDKDEARGRAVERELPGTVFLLCDVTREEDVRTLVSETIRRFGRLDCIVNNAGYHPPPQWPEETSAQGFRQLLELNLLGTYTLTKLALPHLRKSRGNVINISSLVGAIGQSQAVPYVATKGAVTAMTKALALDESQYGVRVNCISPGNIWTPLWEELAASTPDPTATIREGTLAQPLGRMGQPAEVAAAAVFLASEATFCTGTELLVTGGAELGYGRKAGQAAPAEAPTTPS", "length": 273, "header": "tr|A0AAF6YTC1-1|DHB14_BOVIN Computationally mapped isoform of L-fucose dehydrogenase OS=Bos taurus OX=9913 GN=HSD17B14 PE=2 SV=1 CANONICAL=Q9MYP6-1" }, "locus": { "chromosome": "18", "start_pos": 55447426, "end_pos": 55427237, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012090.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012090.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012090.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012090.5" } ] } }, { "isoform_ac": "Q9MYP6-1", "url": "https://www.uniprot.org/uniprotkb/Q9MYP6/entry#Q9MYP6-1", "sequence": { "sequence": "MAMGTRYAGKVVIVTGGGRGIGAGIVRAFVESGAQVVICDKDEARGRAVERELPGTVFLLCDVTREEDVRTLVSETIRRFGRLDCIVNNAGYHPPPQWPEETSAQGFRQLLELNLLGTYTLTKLALPHLRKSRGNVINISSLVGAIGQSQAVPYVATKGAVTAMTKALALDESQYGVRVNCISPGNIWTPLWEELAASTPDPTATIREGTLAQPLGRMGQPAEVAAAAVFLASEATFCTGTELLVTGGAELGYGRKAGQAAPAEAPTTPS", "length": 270, "header": "sp|Q9MYP6-1|DHB14_BOVIN Isoform 1 of L-fucose dehydrogenase OS=Bos taurus OX=9913 GN=HSD17B14 PE=2 SV=1 CANONICAL=Q9MYP6-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 267, "start_aa": "Thr", "end_pos": 267, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr267", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:282652", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282652", "resource": "KEGG Pathway" }, { "id": "R-BTA-193144", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193144", "resource": "Reactome", "description": "Estrogen biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6GJ95-1", "protein_name": "L-fucose dehydrogenase", "gene_name": "Hsd17b14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAVGRYSGKVVVVTGGSRGIGAAIVRAFVDSGAQVVFCDKDEAGGRAVEQELLGTVFIPGDVTQEGDLQTLISETVSRFGHLDCVVNNAGYHPPAQLPEETSAQGFRQLLEENLLGAYTLIKLALPHLRKSKGNIINISSLVGAIGQSQALTYVATKGAVTAMTKALALDESRYGVRVNCISPGNIWTPLWQELAAATSDPRATILEGTLAQPLGRMGQPAEVGAAAVFLASEATFCTGLELFMTGGAELGYGRKASSSTLVEVPILPP", "length": 270 }, "evidence": [ { "id": "Q9MYP6", "url": "https://omabrowser.org/oma/group/Q9MYP6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9Q3D4-1", "protein_name": "L-fucose dehydrogenase", "gene_name": "Hsd17b14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAVTRYSGKVVVVTGGSRGIGAAIVRAFVDSGAQVVFCDKDEAGGRALEQELSGTVFIPGDVTQERDLQTLVSETLSRFGHLDCVVNNAGYHPPAQLPEETSAQGFRQLLEVNLLGTYTLIKLALPHLRKSRGNIINISSLVGAIGQSQALTYVATKGAVTAMTKALALDESRHGVRVNCISPGNIWTPLWEELAASTSDPRATILEGTLAQPLGRMGQPAEVAAAAVFLASEATFCTGLELLVTGGAELGYGRKASKSSLGEVPTLPPNVH", "length": 273 }, "evidence": [ { "id": "Q9MYP6", "url": "https://omabrowser.org/oma/group/Q9MYP6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q75JT8-1", "protein_name": "Short-chain dehydrogenase/reductase family protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "METKEGTFQKQQQDVPGVQSEMNPVPDCGEETYKGNNRLRGRRVLVTGGDSGIGRAVTIAMFREGADVCISYLPSEKKDADSLKCLLEKEIKNTSGGGSGGGTTTCGGKFEMIQGDLTCEKFCKDLVEETKNRLGGLDTLVLVAGKQCAKNCITEITTEQLMETFQVNVFSMFHIVKAALPHLSKGSTITTTTSIEAFSGSPFLLDYATSKGAIVSFTQSLSKQVAHRGIRVNSVAPGPVWTPIEISGGYPQDKLSTFGKNTPMGRAGQPSEVAPMYVFLASCDSTYCTGDIFPVTGGKHL", "length": 301 }, "evidence": [ { "id": "Q9MYP6", "url": "https://omabrowser.org/oma/group/Q9MYP6/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9BPX1-1", "protein_name": "L-fucose dehydrogenase", "gene_name": "HSD17B14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELGYGCKASRSTPVDAPDIPS", "length": 270 }, "evidence": [ { "id": "Q9MYP6", "url": "https://omabrowser.org/oma/group/Q9MYP6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9FZ42-1", "protein_name": "NADPH-dependent aldehyde reductase 1, chloroplastic", "gene_name": "ChlADR1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MASEKQKQHAQPGKEHVMESSPQFSSSDYQPSNKLRGKVALITGGDSGIGRAVGYCFASEGATVAFTYVKGQEEKDAQETLQMLKEVKTSDSKEPIAIPTDLGFDENCKRVVDEVVNAFGRIDVLINNAAEQYESSTIEEIDEPRLERVFRTNIFSYFFLTRHALKHMKEGSSIINTTSVNAYKGNASLLDYTATKGAIVAFTRGLALQLAEKGIRVNGVAPGPIWTPLIPASFNEEKIKNFGSEVPMKRAGQPIEVAPSYVFLACNHCSSYFTGQVLHPNGGAVVNA", "length": 288 }, "evidence": [ { "id": "Q9MYP6", "url": "https://omabrowser.org/oma/group/Q9MYP6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9MYP6", "url": "https://www.uniprot.org/uniprotkb/Q9MYP6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "steroid metabolic process", "id": "GO:0008202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008202", "evidence": [ { "database": "UniProtKB", "id": "Q9MYP6", "url": "https://www.uniprot.org/uniprotkb/Q9MYP6" } ], "pmid": "" }, { "name": "L-fucose catabolic process", "id": "GO:0042355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042355", "evidence": [ { "database": "UniProtKB", "id": "Q9MYP6", "url": "https://www.uniprot.org/uniprotkb/Q9MYP6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "D-threo-aldose 1-dehydrogenase activity", "id": "GO:0047834", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047834", "evidence": [ { "database": "UniProtKB", "id": "Q9MYP6", "url": "https://www.uniprot.org/uniprotkb/Q9MYP6" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q9MYP6", "url": "https://www.uniprot.org/uniprotkb/Q9MYP6" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q9MYP6", "url": "https://www.uniprot.org/uniprotkb/Q9MYP6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "81515", "name": "", "equation": "L-fucose + NAD(+) = L-fucono-1,5-lactone + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9MYP6-1" ], "evidence": [ { "id": "81515", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/81515" } ] }, { "id": "81519", "name": "", "equation": "D-arabinose + NAD(+) = D-arabinono-1,5-lactone + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9MYP6-1" ], "evidence": [ { "id": "81519", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/81519" } ] }, { "id": "81523", "name": "", "equation": "L-galactose + NAD(+) = L-galactono-1,5-lactone + NADH + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9MYP6-1" ], "evidence": [ { "id": "81523", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/81523" } ] }, { "id": "R-BTA-6810594", "name": "HSD17B14 tetramer oxidises estradiol (EST17b) to estrone (E1)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-29366" ], "output_participant_list": [], "enzyme_list": [ "Q9MYP6-1" ], "evidence": [ { "id": "R-BTA-6810594", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6810594" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29366", "participant_name": "NADP+ [cytosol]", "crossref": [ { "id": "58349", "database": "ChEBI", "url": "" }, { "id": "ZINC000008214733", "database": "ZINC", "url": "" }, { "id": "C00006", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q9MYP6", "gene_name": "HSD17B14", "activity": [ { "ec_number": "1.1.1.122", "activity": "L-fucose + NAD(+) = L-fucono-1,5-lactone + NADH + H(+).", "evidence": [ { "id": "Q9MYP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYP6" } ] }, { "ec_number": "1.1.1.122", "activity": "", "evidence": [ { "id": "Q9MYP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MYP6" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9MYP6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 270, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9MYP6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9MYP6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.1.1.122", "ec_name": "L-fucose + NAD(+) = L-fucono-1,5-lactone + NADH + H(+).", "evidence": [ { "id": "1.1.1.122", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.122" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 267 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 138, "end_pos": 140 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q9MZ13-1", "uniprot_ac": "Q9MZ13", "uniprot_id": "VDAC3_BOVIN", "mass": { "chemical_mass": 30739.0, "monoisotopic_mass": 30739.0 }, "refseq": { "ac": "NP_777154", "name": "non-selective voltage-gated ion channel VDAC3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777154" }, "gene_names": [ { "name": "VDAC3", "type": "recommended", "evidence": [ { "id": "Q9MZ13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ] }, { "name": "VDAC1P5", "type": "synonym", "evidence": [ { "id": "NP_777154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777154" } ] }, { "name": "VDAC3", "type": "synonym", "evidence": [ { "id": "NP_777154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777154" } ] }, { "name": "VDAC5P", "type": "synonym", "evidence": [ { "id": "NP_777154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777154" } ] } ], "protein_names": [ { "name": "Non-selective voltage-gated ion channel VDAC3", "type": "recommended", "evidence": [ { "id": "Q9MZ13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13/entry#names_and_taxonomy" } ] }, { "name": "Outer mitochondrial membrane protein porin 3", "type": "synonym", "evidence": [ { "id": "Q9MZ13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13/entry#names_and_taxonomy" } ] }, { "name": "VDAC-3", "type": "synonym", "evidence": [ { "id": "NP_777154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777154" }, { "id": "Q9MZ13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13/entry#names_and_taxonomy" } ] }, { "name": "non-selective voltage-gated ion channel VDAC3", "type": "synonym", "evidence": [ { "id": "NP_777154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777154" } ] }, { "name": "outer mitochondrial membrane protein porin 3", "type": "synonym", "evidence": [ { "id": "NP_777154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777154" } ] }, { "name": "voltage-dependent anion channel 1 pseudogene 5", "type": "synonym", "evidence": [ { "id": "NP_777154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777154" } ] }, { "name": "voltage-dependent anion channel 5, pseudogene", "type": "synonym", "evidence": [ { "id": "NP_777154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777154" } ] }, { "name": "voltage-dependent anion-selective channel protein 3", "type": "synonym", "evidence": [ { "id": "NP_777154", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777154" } ] } ], "function": [ { "annotation": "Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations (By similarity). Involved in male fertility and sperm mitochondrial sheath formation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ13", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13#function" }, { "database": "UniProtKB", "id": "Q60931", "url": "https://www.uniprot.org/uniprotkb/Q60931#function" }, { "database": "UniProtKB", "id": "Q9Y277", "url": "https://www.uniprot.org/uniprotkb/Q9Y277#function" }, { "database": "UniProtKB", "id": "A0A452DIJ5", "url": "https://www.uniprot.org/uniprotkb/A0A452DIJ5#function" }, { "database": "UniProtKB", "id": "ARBA00049964", "url": "https://www.uniprot.org/uniprotkb/ARBA00049964#function" } ] }, { "annotation": "VDAC2 and VDAC3 might have an alternative structural organization and different functions in outer dense fibers than in mitochondria", "evidence": [ { "database": "RefSeq", "id": "NP_777154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777154" }, { "database": "PubMed", "id": "14739283", "url": "https://glygen.org/publication/PubMed/14739283" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9MZ13", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VDAC3", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13", "locus": {} } ], "crossref": [ { "id": "Q9MZ13", "url": "https://alphafold.ebi.ac.uk/entry/Q9MZ13", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd07306", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07306", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282716", "url": "https://www.ncbi.nlm.nih.gov/gene/282716", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001925", "url": 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"categories": [ "Protein Classification" ] }, { "id": "PF01459", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01459", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_777154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777154", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29463", "url": "https://www.rhea-db.org/rhea/29463", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "29823", "url": "https://www.rhea-db.org/rhea/29823", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A452DIJ5", "url": "https://www.uniprot.org/uniprotkb/A0A452DIJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DIJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9MZ13", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9MZ13-1", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLRTKSCSGVEFSTSGHAYTDTGKASGNLETKYKICNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKRDCFSLGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYKLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFNAGGHKVGLGFELEA", "length": 283, "header": "sp|Q9MZ13-1|VDAC3_BOVIN Isoform 1 of Non-selective voltage-gated ion channel VDAC3 OS=Bos taurus OX=9913 GN=VDAC3 PE=2 SV=1 CANONICAL=Q9MZ13-1" }, "isoforms": [ { "isoform_ac": "A0A452DIJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DIJ5/entry", "sequence": { "sequence": "MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLRTKSCSGVEFSTSGHAYTDTGKASGNLETKYKICNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKRDCFSLGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYKLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFNAGGHKLGHLEVHGSRSADAWLGGF", "length": 293, "header": "tr|A0A452DIJ5-1|VDAC3_BOVIN Computationally mapped isoform of Non-selective voltage-gated ion channel VDAC3 OS=Bos taurus OX=9913 GN=VDAC3 PE=2 SV=1 CANONICAL=Q9MZ13-1" }, "locus": { "chromosome": "27", "start_pos": 37259120, "end_pos": 37237546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018691.5", "url": "https://www.ensembl.org/id/ENSBTAT00000018691.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018691.4", "url": "https://www.ensembl.org/id/ENSBTAP00000018691.4" } ] } }, { "isoform_ac": "Q9MZ13-1", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13/entry#Q9MZ13-1", "sequence": { "sequence": "MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLRTKSCSGVEFSTSGHAYTDTGKASGNLETKYKICNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKRDCFSLGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYKLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFNAGGHKVGLGFELEA", "length": 283, "header": "sp|Q9MZ13-1|VDAC3_BOVIN Isoform 1 of Non-selective voltage-gated ion channel VDAC3 OS=Bos taurus OX=9913 GN=VDAC3 PE=2 SV=1 CANONICAL=Q9MZ13-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 241, "end_pos": 241, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ13", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ], "site_lbl": "Ser241" }, { "start_pos": 4, "end_pos": 4, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ13", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ], "site_lbl": "Thr4" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Voltage-dependent anion-selective channels VDAC2 and VDAC3 are abundant proteins in bovine outer dense fibers, a cytoskeletal component of the sperm flagellum.", "journal": "The Journal of biological chemistry", "date": "2004-04-09", "authors": "Hinsch Klaus-Dieter, De Pinto Vito, Aires Viviana A, Schneider Xenia, Messina Angela, Hinsch Elvira", "evidence": [ { "database": "RefSeq", "id": "NP_777154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777154" } ], "reference": [ { "type": "PubMed", "id": "14739283", "url": "https://glygen.org/publication/PubMed/14739283" } ] } ], "pathway": [ { "id": "bta:282716", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282716", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ13", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ], "pmid": "" }, { "name": "porin activity", "id": "GO:0015288", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015288", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ13", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ], "pmid": "" }, { "name": "voltage-gated monoatomic anion channel activity", "id": "GO:0008308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008308", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ13", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ], "pmid": "" }, { "name": "nucleotide binding", "id": "GO:0000166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000166", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ13", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ13", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ13", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ], "pmid": "" }, { "name": "pore complex", "id": "GO:0046930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046930", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ13", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ13", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ], "pmid": "" }, { "name": "sperm mitochondrial sheath assembly", "id": "GO:0120317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120317", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ13", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29463", "name": "", "equation": "K(+)(in) = K(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "29463", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29463" } ] }, { "id": "29823", "name": "", "equation": "chloride(in) = chloride(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MN01-1", "Q5E9B7-1", "Q9XSA7-1", "P35071-1", "P35526-1" ], "evidence": [ { "id": "29823", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29823" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P35526", "gene_name": 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"method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9MZ13-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9MZ13" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q9MZ13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "C-terminal beta-signal", "eco_id": "ECO_0000250", "start_pos": 255, "end_pos": 265, "start_aa": "Val", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "Q9MZ13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZ13" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Mitochondrial localization signal", "eco_id": "ECO_0000250", "start_pos": 233, "end_pos": 237, "start_aa": "Leu", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": 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"Protein Classification" ] }, { "id": "A0A3Q1M4P2", "url": "https://www.orthodb.org/?gene=A0A3Q1M4P2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28572", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28572", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28572:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28572:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13877", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13877", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15867", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15867", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M4P2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4P2-1", "url": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLB4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRKLQKYIDRTKEVAQVPRDLCFSLALDRGICKPESLSPFLCRVCLISCSIIASGFGWKVSFLLKRHLRMGASLVAQMVKNLPAVWETRVGSLDGEHNTGEGNGNPLQYSCLENSMDRAAFSSAGAMKRNDVINFKALEKELQAALIADEKYKRENAAKLRAVEQKVASYEEFRGIVLASHLKPLEQKDKMGGKRPVPWNCHTSQGRPFQDESNELSLEKTLFQPETSAEFYRDWRRHLRSGPERYEALLQLGGPKLGRLFQMDVGFGLLGEMLVALADHVRPADCRAVLGILHSLASTGRFTLNLSLMSRAERESCRALFQKLQAMGTPSSEGQGLGEQPGGLQEEEGLLQELLMLYHVD", "length": 361, "header": "tr|A0A3Q1M4P2-1|A0A3Q1M4P2_BOVIN Isoform 1 of Dynein axonemal assembly factor 19 OS=Bos taurus OX=9913 GN=CCDC103 PE=3 SV=3 CANONICAL=A0A3Q1M4P2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4P2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P2/entry", "sequence": { "sequence": "MRKLQKYIDRTKEVAQVPRDLCFSLALDRGICKPESLSPFLCRVCLISCSIIASGFGWKVSFLLKRHLRMGASLVAQMVKNLPAVWETRVGSLDGEHNTGEGNGNPLQYSCLENSMDRAAFSSAGAMKRNDVINFKALEKELQAALIADEKYKRENAAKLRAVEQKVASYEEFRGIVLASHLKPLEQKDKMGGKRPVPWNCHTSQGRPFQDESNELSLEKTLFQPETSAEFYRDWRRHLRSGPERYEALLQLGGPKLGRLFQMDVGFGLLGEMLVALADHVRPADCRAVLGILHSLASTGRFTLNLSLMSRAERESCRALFQKLQAMGTPSSEGQGLGEQPGGLQEEEGLLQELLMLYHVD", "length": 361, "header": "tr|A0A3Q1M4P2-1|A0A3Q1M4P2_BOVIN Isoform 1 of Dynein axonemal assembly factor 19 OS=Bos taurus OX=9913 GN=CCDC103 PE=3 SV=3 CANONICAL=A0A3Q1M4P2-1" }, "locus": { "chromosome": "19", "start_pos": 44608038, "end_pos": 44604489, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086723.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086723.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064787.3", "url": "https://www.ensembl.org/id/ENSBTAP00000064787.3" } ] } }, { "isoform_ac": "A0AAA9S0C6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0C6/entry", "sequence": { "sequence": "MKAAQLEERSKPPLTLTSGTHLPLLSQKLPVGRWRPCFRPTPPHRLRPPFGRTPQAPRSRFFPGGQPSACGPARRNPGCGHKNLRRGTEGPQTTAGAMKRNDVINFKALEKELQAALIADEKYKRENAAKLRAVEQKVASYEEFRGIVLASHLKPLEQKDKMGGKRPVPWNCHTSQGRPFQDESNELSLEKTLFQPETSAEFYRDWRRHLRSGPERYEALLQLGGPKLGRLFQMDVGFGLLGEMLVALADHVRPADCRAVLGILHSLASTGRFTLNLSLMSRAERESCRALFQKLQAMGTPSSEGQGLGEQPGGLQEEEGLLQELLMLYHVD", "length": 332, "header": "tr|A0AAA9S0C6-1|A0A3Q1M4P2_BOVIN Computationally mapped isoform of Dynein axonemal assembly factor 19 OS=Bos taurus OX=9913 GN=CCDC103 PE=3 SV=1 CANONICAL=A0A3Q1M4P2-1" }, "locus": { "chromosome": "19", "start_pos": 44608038, "end_pos": 44603287, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133083.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133083.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076778.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076778.1" } ] } }, { "isoform_ac": "A0AAA9S5T5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5T5/entry", "sequence": { "sequence": "MTSSTSRLWRKSCRLHSLLMRSTNGRMLPSYGQWNRRGIVLASHLKPLEQKDKMGGKRPVPWNCHTSQGRPFQDESNELSLEKTLFQPETSAEFYRDWRRHLRSGPERYEALLQLGGPKLGRLFQMDVGFGLLGEMLVALADHVRPADCRAVLGILHSLASTGRFTLNLSLMSRAERESCRALFQKLQAMGTPSSEGQGLGEQPGGLQEEEGLLQELLMLYHVD", "length": 224, "header": "tr|A0AAA9S5T5-1|A0A3Q1M4P2_BOVIN Computationally mapped isoform of Dynein axonemal assembly factor 19 OS=Bos taurus OX=9913 GN=CCDC103 PE=3 SV=1 CANONICAL=A0A3Q1M4P2-1" }, "locus": { "chromosome": "19", "start_pos": 44608038, "end_pos": 44606003, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093510.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093510.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078657.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078657.1" } ] } }, { "isoform_ac": "A0AAA9T8T8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T8/entry", "sequence": { "sequence": "MSTLISRKVLVQLRISHHGLHFFLLGSSLPIPSPVPSSENEAHRDCGLASAQRPIPELKTHGFPLLSQSSWKSSALSFPSFVTQEKTLFQPETSAEFYRDWRRHLRSGPERYEALLQLGGPKLGRLFQMDVGFGLLGEMLVALADHVRPADCRAVLGILHSLASTGRFTLNLSLMSRAERESCRALFQKLQAMGTPSSEGQGLGEQPGGLQEEEGLLQELLMLYHVD", "length": 227, "header": "tr|A0AAA9T8T8-1|A0A3Q1M4P2_BOVIN Computationally mapped isoform of Dynein axonemal assembly factor 19 OS=Bos taurus OX=9913 GN=CCDC103 PE=3 SV=1 CANONICAL=A0A3Q1M4P2-1" }, "locus": { "chromosome": "19", "start_pos": 44608038, "end_pos": 44607358, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090273.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090273.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093037.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093037.1" } ] } }, { "isoform_ac": "A0AAA9TLB4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLB4/entry", "sequence": { "sequence": "MKRNDVINFKALEKELQAALIADEKYKRENAAKLRAVEQKVASYEEFRGIVLASHLKPLEQKDKMGGKRPVPWNCHTSQGRPFQDESNELSLSSWKSSA", "length": 99, "header": "tr|A0AAA9TLB4-1|A0A3Q1M4P2_BOVIN Computationally mapped isoform of Dynein axonemal assembly factor 19 OS=Bos taurus OX=9913 GN=CCDC103 PE=3 SV=1 CANONICAL=A0A3Q1M4P2-1" }, "locus": { "chromosome": "19", "start_pos": 44607582, "end_pos": 44605993, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124775.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124775.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097082.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097082.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P2" } ], "pmid": "" }, { "name": "outer dynein arm", "id": "GO:0036157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036157", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P2" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "axonemal dynein complex assembly", "id": "GO:0070286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070286", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P2" } ], "pmid": "" }, { "name": "epithelial cilium movement involved in extracellular fluid movement", "id": "GO:0003351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003351", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P2" } ], "pmid": "" }, { "name": "determination of left/right symmetry", "id": "GO:0007368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007368", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P2" } ], "pmid": "" }, { "name": "inner dynein arm assembly", "id": "GO:0036159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036159", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M4P2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P2" }, { "id": "PF15867", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15867" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Dynein attachment factor N-terminal", "eco_id": "ECO_0000259", "start_pos": 133, "end_pos": 200, "start_aa": "Ile", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1M4P2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P2" }, { "id": "PF13877", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13877" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RNA-polymerase II-associated protein 3-like C-terminal", "eco_id": "ECO_0000259", "start_pos": 224, "end_pos": 314, "start_aa": "Gln", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 305, "end_pos": 307 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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{ "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BP33-1", "uniprot_ac": "E1BP33", "uniprot_id": "E1BP33_BOVIN", "mass": { "chemical_mass": 45355.0, "monoisotopic_mass": 45355.0 }, "refseq": { "ac": "NP_001192491", "name": "Wilms tumor protein 1-interacting protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192491" }, "gene_names": [ { "name": "WTIP", "type": "recommended", "evidence": [ { "id": "E1BP33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ] }, { "name": "WTIP", "type": "synonym", "evidence": [ { "id": "NP_001192491", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192491" } ] } ], "protein_names": [ { "name": "WT1 interacting protein", "type": "synonym", "evidence": [ { "id": "E1BP33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP33/entry#names_and_taxonomy" } ] }, { "name": "Wilms tumor 1 interacting protein", "type": "synonym", "evidence": [ { "id": "NP_001192491", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192491" } ] }, { "name": "Wilms tumor protein 1-interacting protein", "type": "synonym", "evidence": [ { "id": "NP_001192491", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192491" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WTIP", "url": "https://www.uniprot.org/uniprotkb/E1BP33", "locus": { "chromosome": "18", "start_pos": 44907012, "end_pos": 44881174, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007841", "url": "https://www.ensembl.org/id/ENSBTAG00000007841" } ] } } ], "crossref": [ { "id": "E1BP33", "url": "https://alphafold.ebi.ac.uk/entry/E1BP33", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007841", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007841", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09352", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09352", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09355", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09355", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505059", "url": "https://www.ncbi.nlm.nih.gov/gene/505059", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505059", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505059", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RELEPGC", "url": "https://omabrowser.org/oma/group/RELEPGC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BP33", "url": "https://www.orthodb.org/?gene=E1BP33", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24219", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24219", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24219:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24219:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1234176", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1234176", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192491", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S9P2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9P2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9P2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9P2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP33-1", "url": "https://www.uniprot.org/uniprotkb/E1BP33-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQRSRAAADEAALLLAGLALRELEPGGDSPGRGRRGPRPGPADETAQALGRRGQGGGGPEAGVDGLSRGERGPRRAAAPELSAQPAGSPRASLAGSDGGGGSGSARSSGISLGYDQRHGSPRSGRSDPRAGPGPPSVGSARSSVSSLGSRGSAGAYPDLLLPGACPAPARSPEPAGPAPFALPSLQLPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGARQACQAMGSLYHTDCFTCNSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVENNIYCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVECYHCEDCGLQLSGEDGRRCYPLEGHLLCRRCHLRRLRPGPLPSPAVHVTEL", "length": 430, "header": "tr|E1BP33-1|E1BP33_BOVIN Isoform 1 of WT1 interacting protein OS=Bos taurus OX=9913 GN=WTIP PE=3 SV=3 CANONICAL=E1BP33-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9P2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9P2/entry", "sequence": { "sequence": "MQRSRAAADEAALLLAGLALRELEPGGDSPGRGRRGPRPGPADETAQALGRRGQGGGGPEAGVDGLSRGERGPRRAAAPELSAQPAGSPRASLAGSDGGGGSGSARSSGISLGYDQRHGSPRSGRSDPRAGPGPPSVGSARSSVSSLGSRGSAGAYPDLLLPGACPAPARSPEPAGPAPFALPSLQLPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGARQACQAMGSLYHTDCFTCNSCGRRLRGKAFYNVGEKVYCQEDFLILQALGKSYHPGCFRCSVCNECLDGVPFTVDVENNIYCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVECYHCEDCGLQLSGEDGRRCYPLEGHLLCRRCHLRRLRPGPLPSPAVHVTEL", "length": 409, "header": "tr|A0AAA9S9P2-1|E1BP33_BOVIN Computationally mapped isoform of WT1 interacting protein OS=Bos taurus OX=9913 GN=WTIP PE=3 SV=1 CANONICAL=E1BP33-1" }, "locus": { "chromosome": "18", "start_pos": 44905939, "end_pos": 44881373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132689.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132689.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078865.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078865.1" } ] } }, { "isoform_ac": "A0AAA9TI56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI56/entry", "sequence": { "sequence": "MQRSRAAADEAALLLAGLALRELEPGGDSPGRGRRGPRPGPADETAQALGRRGQGGGGPEAGVDGLSRGERGPRRAAAPELSAQPAGSPRASLAGSDGGGGSGSARSSGISLGYDQRHGSPRSGRSDPRAGPGPPSVGSARSSVSSLGSRGSAGAYPDLLLPGACPAPARSPEPAGPAPFALPSLQLPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGARQACQAMGSLYHTDCFTCNSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVENNIYCVRDYHTAARQPSVWCPWTEITTWSATTVRTAGCSSAGRMDAAAIPWKATCCVADATCGASGLGHFPHLLCMSRSSEPGLRARPWGRVCACTNLRFCVRARA", "length": 439, "header": "tr|A0AAA9TI56-1|E1BP33_BOVIN Computationally mapped isoform of WT1 interacting protein OS=Bos taurus OX=9913 GN=WTIP PE=3 SV=1 CANONICAL=E1BP33-1" }, "locus": { "chromosome": "18", "start_pos": 44906018, "end_pos": 44881373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098379.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098379.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096790.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096790.1" } ] } }, { "isoform_ac": "E1BP33-1", "url": "https://www.uniprot.org/uniprotkb/E1BP33/entry", "sequence": { "sequence": "MQRSRAAADEAALLLAGLALRELEPGGDSPGRGRRGPRPGPADETAQALGRRGQGGGGPEAGVDGLSRGERGPRRAAAPELSAQPAGSPRASLAGSDGGGGSGSARSSGISLGYDQRHGSPRSGRSDPRAGPGPPSVGSARSSVSSLGSRGSAGAYPDLLLPGACPAPARSPEPAGPAPFALPSLQLPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGARQACQAMGSLYHTDCFTCNSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVENNIYCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVECYHCEDCGLQLSGEDGRRCYPLEGHLLCRRCHLRRLRPGPLPSPAVHVTEL", "length": 430, "header": "tr|E1BP33-1|E1BP33_BOVIN Isoform 1 of WT1 interacting protein OS=Bos taurus OX=9913 GN=WTIP PE=3 SV=3 CANONICAL=E1BP33-1" }, "locus": { "chromosome": "18", "start_pos": 44905939, "end_pos": 44881373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010314.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010314.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010314.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010314.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505059", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505059", "resource": "KEGG Pathway" }, { "id": "R-BTA-1234176", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1234176", "resource": "Reactome", "description": "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AUF5-1", "protein_name": "WT1 interacting protein", "gene_name": "WTIP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQRSRAAADEAALLLAGLALRELEPGGDSLGRGRRGPRPGPGDEAAQALGRRGQGGGGGPEAGADGLSRGERGPRRAAVPELSTQPAGSPRASLAGSDGGGGGGGSGSARSSGISLGYDQRHGSPRSGRSDPRPGPGPPSVGSARSSVSSLGSRGSAGAYPDLLLPGACPAPARSPEPAGPAPFALPSLQLPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGARQACQAMGSLYHTDCFTCNSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVENNIYCVRDYHSVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVECYHCEDCGLQLSGEDGRRCYPLEGHLLCRRCHLRRLRPGPLPSPAVHVTEL", "length": 434 }, "evidence": [ { "id": "E1BP33", "url": "https://omabrowser.org/oma/group/E1BP33/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A6NIX2-1", "protein_name": "Wilms tumor protein 1-interacting protein", "gene_name": "WTIP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQRSRAGADEAALLLAGLALRELEPGCGSPGRGRRGPRPGPGDEAAPALGRRGKGSGGPEAGADGLSRGERGPRRAAVPELSAQPAGSPRASLAGSDGGGGGGSARSSGISLGYDQRHGSPRSGRSDPRPGPGPPSVGSARSSVSSLGSRGSAGAYADFLPPGACPAPARSPEPAGPAPFPLPALPLPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGAQQACQAMGSLYHTDCFTCDSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVENNIYCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVACYHCEDCGLQLSGEEGRRCYPLAGHLLCRRCHLRRLQPGPLPSPTVHVTEL", "length": 430 }, "evidence": [ { "id": "E1BP33", "url": "https://omabrowser.org/oma/group/E1BP33/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "F1LMC1-1", "protein_name": "WT1 interacting protein", "gene_name": "Wtip", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWHKAVSIRLCSFSREPGRNEEDVGLELGLGGNLECALRPRGGPEPGPPLARPRPCAVCTPLGPAVAAPPTFHRPLRSLLPHIPDGAKESLRSPPPPAPGLRAEGARPGVARAFLRRASPSLPATAPRERAAHAERPLPRPALRGPGAGCGQADDAAALPERRRRREAEVTRRGGPTAMQRSRTAADDAALLLAGLGLRESEPTAGSPGRVRRGPRAADETAPVSGRRGKGGGGPEAAPDVPSRPERGPRASLAGSDGGSARSSGISLGYDQRHGPGPGPPSGGSARSSVSSLGSRGSAGACADLLPPGVGPTPARSPEPAQFPFPLPSLPLPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGARQACQAMGSLYHTDCFICDSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVENNIYCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVECYHCEDCGMQLSGEEGRRCYPLEGHLLCRRCHLRRLGQGPLPSPAVHVTEL", "length": 575 }, "evidence": [ { "id": "E1BP33", "url": "https://omabrowser.org/oma/group/E1BP33/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TQJ8-1", "protein_name": "Wilms tumor protein 1-interacting protein", "gene_name": "Wtip", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQRSRTAADDAALLLAGLGLRESEPTAGSPGRVRRGPRAVDEAAPASGRRGKGGCGGPEAAPDVPSRPERGPRASLAGSDGGSARSSGISLGYDQRHGPGPGPPSGGSARSSVSSLGSRGSAGACADLLPPGVGPAPARSPEPAQFPFPLPSLPLPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGARQACQAMGSLYHTDCFICDSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVDNNIYCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVECYHCEDCGLQLSGEEGRRCYPLEGHLLCRRCHLRRLGQGPLPSPAVHVTEL", "length": 398 }, "evidence": [ { "id": "E1BP33", "url": "https://omabrowser.org/oma/group/E1BP33/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "regulatory ncRNA-mediated gene silencing", "id": "GO:0031047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031047", "evidence": [ { "database": "UniProtKB", "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ], "pmid": "" }, { "name": "response to hypoxia", "id": "GO:0001666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "database": "UniProtKB", "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ], "pmid": "" }, { "name": "miRNA-mediated gene silencing by inhibition of translation", "id": "GO:0035278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035278", "evidence": [ { "database": "UniProtKB", "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ], "pmid": "" }, { "name": "negative regulation of hippo signaling", "id": "GO:0035331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035331", "evidence": [ { "database": "UniProtKB", "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ], "pmid": "" }, { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "P-body", "id": "GO:0000932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000932", "evidence": [ { "database": "UniProtKB", "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "E1BP33", "url": "https://www.uniprot.org/uniprotkb/E1BP33" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BP33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP33" }, { "id": "PS50023", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50023" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding", "eco_id": "ECO_0000259", "start_pos": 223, "end_pos": 284, "start_aa": "Gly", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BP81-1", "uniprot_ac": "E1BP81", "uniprot_id": "E1BP81_BOVIN", "mass": { "chemical_mass": 114175.0, "monoisotopic_mass": 114175.0 }, "refseq": { "ac": "NP_001180138", "name": "semaphorin-6A precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180138" }, "gene_names": [ { "name": "SEMA6A", "type": "recommended", "evidence": [ { "id": "E1BP81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ] }, { "name": "SEMA6A", "type": "synonym", "evidence": [ { "id": "NP_001180138", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180138" } ] } ], "protein_names": [ { "name": "Semaphorin-6A", "type": "recommended", "evidence": [ { "id": "E1BP81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP81/entry#names_and_taxonomy" } ] }, { "name": "Semaphorin VIA", "type": "synonym", "evidence": [ { "id": "E1BP81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP81/entry#names_and_taxonomy" } ] }, { "name": "Semaphorin-6A-1", "type": "synonym", "evidence": [ { "id": "E1BP81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP81/entry#names_and_taxonomy" } ] }, { "name": "sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A", "type": "synonym", "evidence": [ { "id": "NP_001180138", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180138" } ] }, { "name": "semaphorin-6A precursor", "type": "synonym", "evidence": [ { "id": "NP_001180138", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180138" } ] } ], "function": [ { "annotation": "Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.", "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81#function" }, { "database": "UniProtKB", "id": "ARBA00053495", "url": "https://www.uniprot.org/uniprotkb/ARBA00053495#function" }, { "database": "UniProtKB", "id": "A0A3Q1LKD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKD9#function" }, { "database": "UniProtKB", "id": "A0AAA9SHQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHQ8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SEMA6A", "url": "https://www.uniprot.org/uniprotkb/E1BP81", "locus": { "chromosome": "7", "start_pos": 37446210, "end_pos": 37317468, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020489", "url": "https://www.ensembl.org/id/ENSBTAG00000020489" } ] } } ], "crossref": [ { "id": "E1BP81", "url": "https://alphafold.ebi.ac.uk/entry/E1BP81", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020489", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020489", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11266", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11266", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516019", "url": "https://www.ncbi.nlm.nih.gov/gene/516019", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516019", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516019", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HRRKDVT", "url": "https://omabrowser.org/oma/group/HRRKDVT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LKD9", "url": "https://www.orthodb.org/?gene=A0A3Q1LKD9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BP81", "url": "https://www.orthodb.org/?gene=E1BP81", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11036", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11036:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01403", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01403", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01437", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01437", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001180138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180138", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKD9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKD9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHQ8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP81-1", "url": "https://www.uniprot.org/uniprotkb/E1BP81-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSEALLLYFTLLHCAGAAFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIVIMNRTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDTLFVCGTNAFNPSCRNYKMDTLEPVGDEFSGMARCPYDAKHANIALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNSMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIHIHGRDVVLATFSTPYNSIPGSAVCAYDMHDIANVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSTSLEKYTTSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARTGNSGFLNDSLFLEEMSVYNPEKCSYDGVEDKRIMGMQLDKASSFLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWVKEAGACAHLSPSSRLTFEQDIERGNTDGLGDCHNSFVALNGHSSSLLPSTTTSDSAAQEGYESRGGMMDWKESPDSTDSLGAVSSHNHQDKKGVIRESYLKGHDQLVPVTLLAIAVILAFVMGAVFSGIIVYCVCDHRRKDVSSVQRKEKELTHSRRGSMSSVTKLSGLFGDTQSKDPKPEAILTPLMHNGKLATPSNTAKMLIKADQHHLDLAALPTPESTPTLQQKRKPSRGSREWERNQNLINACTKDMPPMGSPVIPTDLPLRASPSHIPSVVVLPTTRQGYQHEYVDQPKMSEVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPPGASLSQNGLSKRLEMRPSSSYGLDYKRSYPTNSLTRSHQAATLKRNNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQAHSSPQPSGQAVTVSRQPSLNSAYNSLTRAGLKRTPSLKPDVPPKPSFAPLSTSMKPNDACT", "length": 1029, "header": "tr|E1BP81-1|E1BP81_BOVIN Isoform 1 of Semaphorin-6A OS=Bos taurus OX=9913 GN=SEMA6A PE=3 SV=1 CANONICAL=E1BP81-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKD9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKD9/entry", "sequence": { "sequence": "MRSEALLLYFTLLHCAGAAFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIVIMNRTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDTLFVCGTNAFNPSCRNYKMDTLEPVGDEFSGMARCPYDAKHANIALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNSMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIHIHGRDVVLATFSTPYNSIPGSAVCAYDMHDIANVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSTSLEKYTTSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARTGNSGFLNDSLFLEEMSVYNPEKCSYDGVEDKRIMGMQLDKASSFLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWVKEAGACAHLSPSSRLTFEQDIERGNTDGLGDCHNSFVALNGVIRESYLKGHDQLVPVTLLAIAVILAFVMGAVFSGIIVYCVCDHRRKDVSSVQRKEKELTHSRRGSMSSVTKLSGLFGDTQSKDPKPEAILTPLMHNGKLATPSNTAKMLIKADQHHLDLAALPTPESTPTLQQKRKPSRGSREWERNQNLINACTKDMPPMGSPVIPTDLPLRASPSHIPSVVVLPTTRQGYQHEYVDQPKMSEVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPPGASLSQNGLSKRLEMRPSSSYGLDYKRSYPTNSLTRSHQAATLKRNNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQAHSSPQPSGQAVTVSRQPSLNSAYNSLTRAGLKRTPSLKPDVPPKPSFAPLSTSMKPNDACT", "length": 977, "header": "tr|A0A3Q1LKD9-1|E1BP81_BOVIN Computationally mapped isoform of Semaphorin-6A OS=Bos taurus OX=9913 GN=SEMA6A PE=3 SV=1 CANONICAL=E1BP81-1" }, "locus": { "chromosome": "7", "start_pos": 37445206, "end_pos": 37382625, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086738.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086738.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060020.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060020.1" } ] } }, { "isoform_ac": "A0AAA9SHQ8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHQ8/entry", "sequence": { "sequence": "MRSEALLLYFTLLHCAGAAFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIVIMNRTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDTLFVCGTNAFNPSCRNYKMDTLEPVGDEFSGMARCPYDAKHANIALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNSMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIHIHGRDVVLATFSTPYNSIPGSAVCAYDMHDIANVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSTSLEKYTTSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARTGNSGFLNDSLFLEEMSVYNPEKCSYDGVEDKRIMGMQLDKASSFLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWVKEAGACAHLSPSSRLTFEQDIERGNTDGLGDCHNSFVALNDISTPLPDHEMSYNTVYGHSSSLLPSTTTSDSAAQEGYESRGGMMDWKESPDSTDSLGAVSSHNHQDKKGVIRESYLKGHDQLVPVTLLAIAVILAFVMGAVFSGIIVYCVCDHRRKDVSSVQRKEKELTHSRRGSMSSVTKLSGLFGDTQSKDPKPEAILTPLMHNGKLATPSNTAKMLIKADQHHLDLAALPTPESTPTLQQKRKPSRGSREWERNQNLINACTKDMPPMGSPVIPTDLPLRASPSHIPSVVVLPTTRQGYQHEYVDQPKMSEVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPPGASLSQNGLSKRLEMRPSSSYGLDYKRSYPTNSLTRSHQAATLKRNNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQAHSSPQPSGQAVTVSRQPSLNSAYNSLTRAGLKRTPSLKPDVPPKPSFAPLSTSMKPNDACT", "length": 1046, "header": "tr|A0AAA9SHQ8-1|E1BP81_BOVIN Computationally mapped isoform of Semaphorin-6A OS=Bos taurus OX=9913 GN=SEMA6A PE=3 SV=1 CANONICAL=E1BP81-1" }, "locus": { "chromosome": "7", "start_pos": 37445206, "end_pos": 37382625, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117043.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117043.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082048.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082048.1" } ] } }, { "isoform_ac": "E1BP81-1", "url": "https://www.uniprot.org/uniprotkb/E1BP81/entry", "sequence": { "sequence": "MRSEALLLYFTLLHCAGAAFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIVIMNRTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDTLFVCGTNAFNPSCRNYKMDTLEPVGDEFSGMARCPYDAKHANIALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNSMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIHIHGRDVVLATFSTPYNSIPGSAVCAYDMHDIANVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSTSLEKYTTSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARTGNSGFLNDSLFLEEMSVYNPEKCSYDGVEDKRIMGMQLDKASSFLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWVKEAGACAHLSPSSRLTFEQDIERGNTDGLGDCHNSFVALNGHSSSLLPSTTTSDSAAQEGYESRGGMMDWKESPDSTDSLGAVSSHNHQDKKGVIRESYLKGHDQLVPVTLLAIAVILAFVMGAVFSGIIVYCVCDHRRKDVSSVQRKEKELTHSRRGSMSSVTKLSGLFGDTQSKDPKPEAILTPLMHNGKLATPSNTAKMLIKADQHHLDLAALPTPESTPTLQQKRKPSRGSREWERNQNLINACTKDMPPMGSPVIPTDLPLRASPSHIPSVVVLPTTRQGYQHEYVDQPKMSEVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPPGASLSQNGLSKRLEMRPSSSYGLDYKRSYPTNSLTRSHQAATLKRNNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQAHSSPQPSGQAVTVSRQPSLNSAYNSLTRAGLKRTPSLKPDVPPKPSFAPLSTSMKPNDACT", "length": 1029, "header": "tr|E1BP81-1|E1BP81_BOVIN Isoform 1 of Semaphorin-6A OS=Bos taurus OX=9913 GN=SEMA6A PE=3 SV=1 CANONICAL=E1BP81-1" }, "locus": { "chromosome": "7", "start_pos": 37445206, "end_pos": 37382625, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043906.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043906.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041442.2", "url": "https://www.ensembl.org/id/ENSBTAP00000041442.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 980, "start_aa": "Thr", "end_pos": 980, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr980", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:516019", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516019", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B6K3-1", "protein_name": "Semaphorin-6A", "gene_name": "SEMA6A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRSEVLLLYFTLLHFAGAGFPEDSEPISISHGNYTKQYPVFVGHKPGRNSTQRHRLDIQMIMIMNRTLYIAARDHIYTVDIDTSQTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDTLFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMARCPYDAKHANIALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLDIANVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFLEEMSVYNPEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWVKEGGTCAHLSPSSRLTFEQDIERGNTDGLGDCHNSFVALNDISTPLPDHEMSYNTVHGHSSSLLPSTTTSDSAAQEGSESRRGMLDWNDLLHSPDSTDSLGAVSSHNHQDKKGVIRESYLKGHDQLVPVTLLAIAVILAFVMGAVFSGIIVYCVCDHRRKDVSSVQRKEKELTHSRRGSMSSVTKLSGLFGDTQSKDPKPEAILTPLMHNGKLTTPGNTAKMLIKADQHHLDLAALPTPESTPTLQQKRKPSRGSREWERNQNLINACTKDMPPMGSPVIPTDLPLRASPSHIPSVVVLPITQQGYQHEYVDQPKMSEVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPPGASLSQNGLSKRLEMHHSSSYGLDYKRSYPTNSLTRSHQAATLKRNNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQVHSSQPSGQAVTVSRQPSLNAYNSLTRAGLKRTPSLKPDVPPKPSFAPLSTSMKPNDACT", "length": 1047 }, "evidence": [ { "id": "E1BP81", "url": "https://omabrowser.org/oma/group/E1BP81/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZAG0-1", "protein_name": "Semaphorin-6A", "gene_name": "Sema6a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRPAALLLCLTLLRCAGAGFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIMIMNRTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDTLFVCGTNAFNPSCRNYRVDTLETFGDEFSGMARCPYDAKHANIALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLDIANVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLTKIAVDNTAGPYENHTVVFLGSEKGIILKFLARIGSSGFLNGSLFLEEMNVYNPEKCSYDGVEDKRIMGMQLDKASGSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWVKETGSCAHLSPLSRLAFEQDIERGNTDGLGDCHNSFVALNGRASSLYPSTTTSDSASRDGHESQGGMLDWNDLLKAPGNTDPLGAVSSHNHQDKKGVIRESYLKSNDQLVPVTLLAIAVILAFVMGAVFSGIIVYCVCDHRRKDVAVVQRKEKELTHSRRGSMSSVTKLSGLFGDSQSKDPKPEAILTPLMHNGKLATPSNTAKMLIKADQHHLDLTALPTPESTPTLQQKRKPNRGSREWERNQNLINACTKDMPPMGSPVIPTDLPLRASPSHIPSVVVLPITQQGYQHEYVDQPKMSEVVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPTGASLSQTGLSKRLEMQHSSSYGLEYKRSYPTNSLTRSHQATTLKRNNTNSSNSSHLSRNQSLGRGDNPPPAPQRVDSIQVHSPQPSGQAVTVSRQPSLNAYNSLTRSGLKRTPSLKPDVPPKPSFAPLSTSMKPNDACT", "length": 1031 }, "evidence": [ { "id": "E1BP81", "url": "https://omabrowser.org/oma/group/E1BP81/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1C1C2-1", "protein_name": "Semaphorin-6A", "gene_name": "SEMA6A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRSEALLLYFTLLHFAGAGFPEDSEPISISHGNYTRQYPVFVGHKPGRNTTQRHRLDIQLVTVMNRTLYIAARDHIYTVDMDTSHTEEIYFSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKRNEDTLFICGTNAFNPSCRNYKMDTLEFLGDEFSGMARCPYDAKHANVALFAEGKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAVDYGNYIYFFFREIAVEYNSMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIHFNGRDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSTSLEKYATSSEFPDDTLNFIKTHPLMDEAVPSIVNRPWFLRTMVRYRLTKITVDSAAGPYKNYTVVFLGSEKGIILKFLARTGNSGFLNDSLFLEEMNIYNPEKCSYDGMEDKRIVAMQLDKPSSALYVAFSTCVIKVPLGRCERHGKCKKACIASRDPYCGWVKESGACTQLVLGAKLAFDQDIEHGNTDGLGDCQNSFVALNDISTASPDHEMSYNTVYGHSSSLVPSTTSSDSWARQGYDARGRMLDWKDPLGSSENTDPYVAVSSHNHQDKKGVIRESYLKGHDQLVPVTLLAIAVILAFVMGAVFSGIIVYCICDHRRRDVAVVQRKEKELTHSRRGSMSSVTKLSGLFGDAQSKEPKPEAILTPLMHNGKLATPGSTTKMLIKADQHHLDLAALPTPESTPTLQQKRKPSRGSREWERNQNLINACTKDIPPMASPVIPTDLPLRASPSHIPSVMVLPIAQQGYQHEYVDQPKMSDGAQMSVEDQNATLEYKTIKDHLSSKSPSHGVNLVENLDSMPPKVPQREASLGPPSTSLSQSGLSKRLDMHSSAYSVDYKRNYPTNSLTRSHQASTLKRNNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQVHAAQAQAMTVSRQPSLTTYNSLTRSGLKRTPSLKPDVPPKPSFAPLSTSMKPNDACT", "length": 1044 }, "evidence": [ { "id": "E1BP81", "url": "https://omabrowser.org/oma/group/E1BP81/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O35464-1", "protein_name": "Semaphorin-6A", "gene_name": "Sema6a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRPAALLLCLTLLHCAGAGFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIMIMNRTLYVAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDTLFVCGTNAFNPSCRNYRVDTLETFGDEFSGMARCPYDAKHANIALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLDIANVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLTKIAVDNAAGPYQNHTVVFLGSEKGIILKFLARIGSSGFLNGSLFLEEMNVYNPEKCSYDGVEDKRIMGMQLDRASGSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWVRESGSCAHLSPLSRLTFEQDIERGNTDGLGDCHNSFVALNGHASSLYPSTTTSDSASRDGYESRGGMLDWNDLLEAPGSTDPLGAVSSHNHQDKKGVIRESYLKSNDQLVPVTLLAIAVILAFVMGAVFSGIIVYCVCDHRRKDVAVVQRKEKELTHSRRGSMSSVTKLSGLFGDTQSKDPKPEAILTPLMHNGKLATPSNTAKMLIKADQHHLDLTALPTPESTPTLQQKRKPNRGSREWERNQNIINACTKDMPPMGSPVIPTDLPLRASPSHIPSVVVLPITQQGYQHEYVDQPKMSEVVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPPGTSLSQTGLSKRLEMQHSSSYGLEYKRSYPTNSLTRSHQTTTLKRNNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQVHSSQPSGQAVTVSRQPSLNAYNSLTRSGLKRTPSLKPDVPPKPSFAPLSTSMKPNDACT", "length": 1031 }, "evidence": [ { "id": "E1BP81", "url": "https://omabrowser.org/oma/group/E1BP81/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H2E6-1", "protein_name": "Semaphorin-6A", "gene_name": "SEMA6A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRSEALLLYFTLLHFAGAGFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIMIMNGTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMARCPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFLEEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWIKEGGACSHLSPNSRLTFEQDIERGNTDGLGDCHNSFVALNGHSSSLLPSTTTSDSTAQEGYESRGGMLDWKHLLDSPDSTDPLGAVSSHNHQDKKGVIRESYLKGHDQLVPVTLLAIAVILAFVMGAVFSGITVYCVCDHRRKDVAVVQRKEKELTHSRRGSMSSVTKLSGLFGDTQSKDPKPEAILTPLMHNGKLATPGNTAKMLIKADQHHLDLTALPTPESTPTLQQKRKPSRGSREWERNQNLINACTKDMPPMGSPVIPTDLPLRASPSHIPSVVVLPITQQGYQHEYVDQPKMSEVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPPGASLSQTGLSKRLEMHHSSSYGVDYKRSYPTNSLTRSHQATTLKRNNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQVHSSQPSGQAVTVSRQPSLNAYNSLTRSGLKRTPSLKPDVPPKPSFAPLSTSMKPNDACT", "length": 1030 }, "evidence": [ { "id": "E1BP81", "url": "https://omabrowser.org/oma/group/E1BP81/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ], "pmid": "" }, { "name": "negative regulation of ERK1 and ERK2 cascade", "id": "GO:0070373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070373", "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ], "pmid": "" }, { "name": "negative regulation of vascular endothelial growth factor signaling pathway", "id": "GO:1900747", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900747", "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ], "pmid": "" }, { "name": "cellular response to vascular endothelial growth factor stimulus", "id": "GO:0035924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035924", "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ], "pmid": "" }, { "name": "negative regulation of cell adhesion involved in sprouting angiogenesis", "id": "GO:0106089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106089", "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ], "pmid": "" }, { "name": "semaphorin-plexin signaling pathway", "id": "GO:0071526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071526", "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ], "pmid": "" }, { "name": "neural crest cell migration", "id": "GO:0001755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001755", "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ], "pmid": "" }, { "name": "positive regulation of neuron migration", "id": "GO:2001224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001224", "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "semaphorin receptor binding", "id": "GO:0030215", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030215", "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ], "pmid": "" }, { "name": "chemorepellent activity", "id": "GO:0045499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045499", "evidence": [ { "database": "UniProtKB", "id": "E1BP81", "url": "https://www.uniprot.org/uniprotkb/E1BP81" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" }, { "start_pos": 434, "end_pos": 436, "annotation": "n_glycosylation_sequon" 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"header": "tr|E1BP08-1|E1BP08_BOVIN Isoform 1 of Bactericidal permeability-increasing protein OS=Bos taurus OX=9913 GN=BPIFC PE=3 SV=2 CANONICAL=E1BP08-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TRR8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRR8/entry", "sequence": { "sequence": "MVSIFGDYIPQSASYYFINLVVSNSVRPLRQQPTRLPRPWDSPGKNTGVGCHFLLQCKKVKSESEVAQSCPTLRDPVDCSLPGSSVHGIFQDPVQGVTLHLVVVPYEFKAPVENTSTSKAEGTEGAPWLWILPLLEMCTKMAQVQVLWGCFLLWNLYISSAQAIYPGIKARATQRALDYAVQAGMEMIEQMAKERKLPDLKGSESLEFVKIDYVNYNFTNIKINAFSFPNTSLSFVPGVGIKALTNHGTTNISTDWEVKSPLFQDTGAADLFLSGVYFTGIVVLSRNDFGHPILKLQDCYAQVSHADVSFSGELSVLYNSFAEPMEKPILKKLNEMLCPIITGEVEALNANLSMLEVLRKIDNYTLLDYSLISSPEITENYFDLNLKGVFYPLKSLRYPPFPSVPFVLPERRDSMLYIGISEYFFKSASYAYFTAGAFSFTLTTKEISNHLLHNSQAHGNMLSRIAELYILSKPFMVQVMATEPPVISLLPGNFTLDIPASIMILTQPENSTAETIVSMDFVASTNVALAILGQRLICSLSLNRFRLSLPESNRGNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYKTSKQQPGFHGWEDLHLISGQWSGKPTP", "length": 644, "header": "tr|A0AAA9TRR8-1|E1BP08_BOVIN 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"MVSIFGDYIPQSASYYFINLADEFKAPVENTSTSKAEGTEGAPWLWILPLLEMCTKMAQVQVLWGCFLLWNLYISSAQAIYPGIKARATQRALDYAVQAGMEMIEQMAKERKLPDLKGSESLEFVKIDYVNYNFTNIKINAFSFPNTSLSFVPGVGIKALTNHGTTNISTDWEVKSPLFQDTGAADLFLSGVYFTGIVVLSRNDFGHPILKLQDCYAQVSHADVSFSGELSVLYNSFAEPMEKPILKKLNEMLCPIITGEVEALNANLSMLEVLRKIDNYTLLDYSLISSPEITENYFDLNLKGVFYPLKSLRYPPFPSVPFVLPERRDSMLYIGISEYFFKSASYAYFTAGAFSFTLTTKEISNHLLHNSQAHGNMLSRIAELYILSKPFMVQVMATEPPVISLLPGNFTLDIPASIMILTQPENSTAETIVSMDFVASTNVALAILGQRLICSLSLNRFRLSLPESNRGNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYKTSKQQPGFHGWEDLHLISGQWSGKPTP", "length": 560, "header": "tr|A0AAA9TWF4-1|E1BP08_BOVIN Computationally mapped isoform of Bactericidal permeability-increasing protein OS=Bos taurus OX=9913 GN=BPIFC PE=3 SV=1 CANONICAL=E1BP08-1" }, "locus": { "chromosome": "5", "start_pos": 71096348, "end_pos": 71042928, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092857.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092857.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100952.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100952.1" } ] } }, { "isoform_ac": "E1BP08-1", "url": "https://www.uniprot.org/uniprotkb/E1BP08/entry", "sequence": { "sequence": "MSQMCTKMAQVQVLWGCFLLWNLYISSAQAIYPGIKARATQRALDYAVQAGMEMIEQMAKERKLPDLKGSESLEFVKIDYVNYNFTNIKINAFSFPNTSLSFVPGVGIKALTNHGTTNISTDWEVKSPLFQDTGAADLFLSGVYFTGIVVLSRNDFGHPILKLQDCYAQVSHADVSFSGELSVLYNSFAEPMEKPILKKLNEMLCPIITGEVEALNANLSMLEVLRKIDNYTLLDYSLISSPEITENYFDLNLKGVFYPLKSLRYPPFPSVPFVLPERRDSMLYIGISEYFFKSASYAYFTAGAFSFTLTTKEISNHLLHNSQAHGNMLSRIAELYILSKPFMVQVMATEPPVISLLPGNFTLDIPASIMILTQPENSTAETIVSMDFVASTNVALAILGQRLICSLSLNRFRLSLPESNRGNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYKTSKQQPGFHGWEDLHLISGQWSGKPTP", "length": 511, "header": "tr|E1BP08-1|E1BP08_BOVIN Isoform 1 of Bactericidal permeability-increasing protein OS=Bos taurus OX=9913 GN=BPIFC PE=3 SV=2 CANONICAL=E1BP08-1" }, "locus": { "chromosome": "5", "start_pos": 71079929, "end_pos": 71042928, 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"https://www.genome.jp/dbget-bin/www_bget?bta:507480", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RERIMPA", "url": "https://omabrowser.org/oma/group/RERIMPA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BP65", "url": "https://www.orthodb.org/?gene=E1BP65", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10985", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10985", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07527", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07527", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015330684", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330684", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TTN4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP65", "url": "https://www.uniprot.org/uniprotkb/E1BP65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP65-1", "url": "https://www.uniprot.org/uniprotkb/E1BP65-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPADIPGKPRASPRAGAAAGASRTPDQPRSVAEHRKSSKPVMEKRRRARINESLAQLQSLLLDALRKESSRRSKLEKADILELTVRHLQSLRRVQVTAALRSDPAILGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLCHLAACLARLGPARRPLPLAPATEAQEPEIYAGRPPPPAFDGPCPLPRPGAALAPIFLPGLALAAPGAGAQGQGAPWRPWLR", "length": 222, "header": "tr|E1BP65-1|E1BP65_BOVIN Isoform 1 of Hes family bHLH transcription factor 4 OS=Bos taurus OX=9913 GN=HES4 PE=4 SV=1 CANONICAL=E1BP65-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TTN4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTN4/entry", "sequence": { "sequence": "AWDPREKCLGNRAPSLPSAGGGEGAHHACGHPGEAEGLAAGGSGGRRQPDPRPAPERGRAPEVLQAGHGEAAPSAHQRESGSAAEPPPGRPQERGELGVGTRLGSLESRPSWAARRPHRPRPQSSRRSKLEKADILELTVRHLQSLRRVQVTAALRSDPAILGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLCHLAACLARLGPARRPLPLAPATEAQEPEIYAGRPPPPAFDGPCPLPRPGAALAPIFLPGLALAAPGAGAQGQGAPWRPWLR", "length": 277, "header": "tr|A0AAA9TTN4-1|E1BP65_BOVIN Computationally mapped isoform of Hes family bHLH transcription factor 4 OS=Bos taurus OX=9913 GN=HES4 PE=4 SV=1 CANONICAL=E1BP65-1" }, "locus": { "chromosome": "16", "start_pos": 51475188, "end_pos": 51474166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114172.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114172.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100729.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100729.1" } ] } }, { "isoform_ac": "E1BP65-1", "url": "https://www.uniprot.org/uniprotkb/E1BP65/entry", "sequence": { "sequence": "MPADIPGKPRASPRAGAAAGASRTPDQPRSVAEHRKSSKPVMEKRRRARINESLAQLQSLLLDALRKESSRRSKLEKADILELTVRHLQSLRRVQVTAALRSDPAILGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLCHLAACLARLGPARRPLPLAPATEAQEPEIYAGRPPPPAFDGPCPLPRPGAALAPIFLPGLALAAPGAGAQGQGAPWRPWLR", "length": 222, "header": "tr|E1BP65-1|E1BP65_BOVIN Isoform 1 of Hes family bHLH transcription factor 4 OS=Bos taurus OX=9913 GN=HES4 PE=4 SV=1 CANONICAL=E1BP65-1" }, "locus": { "chromosome": "16", "start_pos": 51475188, "end_pos": 51474245, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019571.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019571.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019571.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019571.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507480", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507480", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AS85-1", "protein_name": "Hes family bHLH transcription factor 4", "gene_name": "HES4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPADTPGKPRASPLAGAPASASRTPNEPRSAAEPRKSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLQSLRRVQVTAALSADPAVLGKYRAGFNECLAEVNRFLVGCEGVPADVRSRLLGHLAACLGQLGPPLRPVPPSLVAEALAPDVYAGRPPQPDFDSPFPPPPRPGAAFALPILPGRTGAPLAAAGAGAGPQGQGVPWRPWLR", "length": 228 }, "evidence": [ { "id": "E1BP65", "url": "https://omabrowser.org/oma/group/E1BP65/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9HCC6-1", "protein_name": "Transcription factor HES-4", "gene_name": "HES4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSRRPASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGGPWRPWLR", "length": 221 }, "evidence": [ { "id": "E1BP65", "url": "https://omabrowser.org/oma/group/E1BP65/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BP65", "url": "https://www.uniprot.org/uniprotkb/E1BP65" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "E1BP65", "url": "https://www.uniprot.org/uniprotkb/E1BP65" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BP65", "url": "https://www.uniprot.org/uniprotkb/E1BP65" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BP65", "url": "https://www.uniprot.org/uniprotkb/E1BP65" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BP65", "url": "https://www.uniprot.org/uniprotkb/E1BP65" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BP65", "url": "https://www.uniprot.org/uniprotkb/E1BP65" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "E1BP65", "url": "https://www.uniprot.org/uniprotkb/E1BP65" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "E1BP65", "url": "https://www.uniprot.org/uniprotkb/E1BP65" } ], "pmid": "" }, { "name": "anterior/posterior pattern specification", "id": "GO:0009952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009952", "evidence": [ { "database": "UniProtKB", "id": "E1BP65", "url": "https://www.uniprot.org/uniprotkb/E1BP65" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BP65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP65" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 91, "start_aa": "His", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BP65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP65" }, { "id": "PS51054", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51054" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Orange", "eco_id": "ECO_0000259", "start_pos": 110, "end_pos": 143, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 51, "end_pos": 53 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LYT6-1", "uniprot_ac": "A0A3Q1LYT6", "uniprot_id": "A0A3Q1LYT6_BOVIN", "mass": { "chemical_mass": 28728.0, "monoisotopic_mass": 28728.0 }, "refseq": { "ac": "XP_002692874", "name": "carbonic anhydrase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692874" }, "gene_names": [ { "name": "LOC784254", "type": "recommended", "evidence": [ { "id": "A0A3Q1LYT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6" } ] }, { "name": "LOC784254", "type": "synonym", "evidence": [ { "id": "XP_002692874", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692874" } ] } ], "protein_names": [ { "name": "Carbonic anhydrase", "type": "recommended", "evidence": [ { "id": "A0A3Q1LYT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6/entry#names_and_taxonomy" } ] }, { "name": "4.2.1.1", "type": "synonym", "evidence": [ { "id": "A0A3Q1LYT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6/entry#names_and_taxonomy" } ] }, { "name": "carbonic anhydrase 1", "type": "synonym", "evidence": [ { "id": "XP_002692874", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692874" } ] } ], "function": [ { "annotation": "Catalyzes the reversible hydration of carbon dioxide. Can hydrate cyanamide to urea.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYT6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6#function" }, { "database": "UniProtKB", "id": "ARBA00045744", "url": "https://www.uniprot.org/uniprotkb/ARBA00045744#function" } ] }, { "annotation": "Reversible hydration of carbon dioxide.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYT6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6#function" }, { "database": "UniProtKB", "id": "RU367011", "url": "https://www.uniprot.org/uniprotkb/RU367011#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYT6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC784254", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6", "locus": {} } ], "crossref": [ { "id": "A0A3Q1LYT6", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LYT6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051812", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051812", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "784254", "url": "https://www.ncbi.nlm.nih.gov/gene/784254", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036398", "url": 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"database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10748", "url": "https://www.rhea-db.org/rhea/10748", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "23056", "url": "https://www.rhea-db.org/rhea/23056", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LYT6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYT6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASPDWGYDGENGPEHWGKLYPIANGNNQSPIDIKTSETKRDPSLKPLSVSYNPATAKEIVNVGHSFHVNFEDSDNRSVLKGGPLSESYRLRQFHFHWGITDDCGSEHLVDGAKFSAELHLVHWNSAKYPSFADAASKADGLALIGVLVKVGQANPNLQKVLDALKAVKNKNKKAPFTNFDPSVLLPPSLDYWAYSGSLTHPPLHESVTWIIFKETISASSEQLAQFRCLLANAEGDGELCIKQNHRPPQPLKGRTVKASF", "length": 261, "header": "tr|A0A3Q1LYT6-1|A0A3Q1LYT6_BOVIN Isoform 1 of Carbonic anhydrase OS=Bos taurus OX=9913 GN=LOC784254 PE=1 SV=3 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"evidence": [ { "id": "A0A3Q1M355", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355/entry#names_and_taxonomy" } ] }, { "name": "outer dense fiber protein 2 isoform X12", "type": "synonym", "evidence": [ { "id": "XP_024854760", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854760" } ] } ], "function": [ { "annotation": "Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.", "evidence": [ { "database": "UniProtKB", "id": "F1MU43", "url": "https://www.uniprot.org/uniprotkb/F1MU43#function" }, { "database": "UniProtKB", "id": "ARBA00037601", "url": "https://www.uniprot.org/uniprotkb/ARBA00037601#function" }, { "database": "UniProtKB", "id": "A0A3Q1MC61", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC61#function" }, { "database": "UniProtKB", "id": "A0A3Q1LHX7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHX7#function" }, { "database": "UniProtKB", "id": "A0A3Q1LM23", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM23#function" }, { "database": "UniProtKB", "id": "A0A3Q1M355", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355#function" }, { "database": "UniProtKB", "id": "A0ABI0NNV2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNV2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M355", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ODF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355", "locus": { "chromosome": "11", "start_pos": 99063573, "end_pos": 99034296, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030567", "url": "https://www.ensembl.org/id/ENSBTAG00000030567" } ] } } ], "crossref": [ { "id": "A0A3Q1M355", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M355", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030567", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030567", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539043", "url": "https://www.ncbi.nlm.nih.gov/gene/539043", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HVHINDT", "url": "https://omabrowser.org/oma/group/HVHINDT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LHX7", "url": "https://www.orthodb.org/?gene=A0A3Q1LHX7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LM23", "url": "https://www.orthodb.org/?gene=A0A3Q1LM23", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M355", "url": "https://www.orthodb.org/?gene=A0A3Q1M355", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MC61", "url": "https://www.orthodb.org/?gene=A0A3Q1MC61", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MU43", "url": "https://www.orthodb.org/?gene=F1MU43", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23162", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23162", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23162:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23162:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27578", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27578", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27605", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27605", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2565942", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380259", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380284", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-380320", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854518", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024854760", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854760", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LHX7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LHX7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LM23", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LM23-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM23-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M355", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M355-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC61", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MC61-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NNV2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NNV2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNV2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MU43", "url": "https://www.uniprot.org/uniprotkb/F1MU43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MU43-1", "url": "https://www.uniprot.org/uniprotkb/F1MU43-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGELPTGCRKRRRKRGGVAAGAGLHPPRRLHGTALASDFNDFIRRRFWAQPCRSWFPSCGKNGVTSLTQKKVLRTPCGAPSVTVTNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAQELAETEHENTVLRHNIERIKEEKDYTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKSEKQMTCSDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEDLLQEIQCEKAQAKTASELSKSMETMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGERDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHIEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHAASKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTSRSMQNYVQFLKSSYANVFGDGPYASYLTSSPIRSRSPPT", "length": 831, "header": "tr|A0A3Q1M355-1|A0A3Q1M355_BOVIN Isoform 1 of Outer dense fiber protein 2 OS=Bos taurus OX=9913 GN=ODF2 PE=3 SV=2 CANONICAL=A0A3Q1M355-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LHX7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHX7/entry", "sequence": { "sequence": "MSASSSGGSPRFPSCGKNGVTSLTQKKVLRTPCGAPSVTVTKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAQELAETEHENTVLRHNIERIKEEKDYTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKSEKQMTCSDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEDLLQEIQCEKAQAKTASELSKSMETMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGERDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHIEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVVR", "length": 621, "header": "tr|A0A3Q1LHX7-1|A0A3Q1M355_BOVIN Computationally mapped isoform of Outer dense fiber protein 2 OS=Bos taurus OX=9913 GN=ODF2 PE=3 SV=3 CANONICAL=A0A3Q1M355-1" }, "locus": { "chromosome": "11", "start_pos": 99059399, "end_pos": 99036576, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079857.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079857.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058469.3", "url": "https://www.ensembl.org/id/ENSBTAP00000058469.3" } ] } }, { "isoform_ac": "A0A3Q1LM23-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM23/entry", "sequence": { "sequence": "MSASSSGGSPRFPSCGKNGVTSLTQKKVLRTPCGAPSVTVTKRTMKDRSSTPPLHVHVDENTPVHVHIKKLSKTSATNSQKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCNWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAQELAETEHENTVLRHNIERIKEEKDYTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKSEKQMTCSDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEDLLQEIQCEKAQAKTASELSKSMETMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGERDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHIEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELARAGARLPR", "length": 696, "header": "tr|A0A3Q1LM23-1|A0A3Q1M355_BOVIN Computationally mapped isoform of Outer dense fiber protein 2 OS=Bos taurus OX=9913 GN=ODF2 PE=3 SV=3 CANONICAL=A0A3Q1M355-1" }, "locus": { "chromosome": "11", "start_pos": 99058255, "end_pos": 99036576, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083421.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083421.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057867.3", "url": "https://www.ensembl.org/id/ENSBTAP00000057867.3" } ] } }, { "isoform_ac": "A0A3Q1M355-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355/entry", "sequence": { "sequence": "MGELPTGCRKRRRKRGGVAAGAGLHPPRRLHGTALASDFNDFIRRRFWAQPCRSWFPSCGKNGVTSLTQKKVLRTPCGAPSVTVTNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAQELAETEHENTVLRHNIERIKEEKDYTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKSEKQMTCSDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEDLLQEIQCEKAQAKTASELSKSMETMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGERDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHIEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHAASKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTSRSMQNYVQFLKSSYANVFGDGPYASYLTSSPIRSRSPPT", "length": 831, "header": "tr|A0A3Q1M355-1|A0A3Q1M355_BOVIN Isoform 1 of Outer dense fiber protein 2 OS=Bos taurus OX=9913 GN=ODF2 PE=3 SV=2 CANONICAL=A0A3Q1M355-1" }, "locus": { "chromosome": "11", "start_pos": 99062569, "end_pos": 99035080, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068517.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068517.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067905.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067905.2" } ] } }, { "isoform_ac": "A0A3Q1MC61-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MC61/entry", "sequence": { "sequence": "MSASSSGGSPRFPSCGKNGVTSLTQKKVLRTPCGAPSVTVTKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCNWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAQELAETEHENTVLRHNIERIKEEKDYTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKSEKQMTCSDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEDLLQEIQCEKAQAKTASELSKSMETMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGERDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHIEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHAASKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTSRSMQNYVQFLKSSYANVFGDGPYASYLTSSPIRSRSPPT", "length": 829, "header": "tr|A0A3Q1MC61-1|A0A3Q1M355_BOVIN Computationally mapped isoform of Outer dense fiber protein 2 OS=Bos taurus OX=9913 GN=ODF2 PE=3 SV=3 CANONICAL=A0A3Q1M355-1" }, "locus": { "chromosome": "11", "start_pos": 99062569, "end_pos": 99036576, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078075.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078075.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071683.3", "url": "https://www.ensembl.org/id/ENSBTAP00000071683.3" } ] } }, { "isoform_ac": "A0ABI0NNV2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNV2/entry", "sequence": { "sequence": "MKDRSSTPPLHVHVDENTPVHVHIKKLSKTSATNSQKSHKRGMKGDTVNVRRSVRVKTKVKMQKGERQMAKRFLEERKEELEEVAQELAETEHENTVLRHNIERIKEEKDYTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKSEKQMTCSDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEDLLQEIQCEKAQAKTASELSKSMETMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGERDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHIEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELARAGARLPR", "length": 576, "header": "tr|A0ABI0NNV2-1|A0ABI0NNV2_BOVIN Computationally mapped isoform of Outer dense fiber protein 2 OS=Bos taurus OX=9913 GN=ODF2 PE=3 SV=1 CANONICAL=A0A3Q1M355-1" }, "locus": { "chromosome": "11", "start_pos": 99058255, "end_pos": 99038906, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136950.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136950.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104608.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104608.1" } ] } }, { "isoform_ac": "F1MU43-1", "url": "https://www.uniprot.org/uniprotkb/F1MU43/entry", "sequence": { "sequence": "MKDRSSTPPLHVHVDENTPVHVHIKKLSKTSATNSQKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCNWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAQELAETEHENTVLRHNIERIKEEKDYTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKSEKQMTCSDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEDLLQEIQCEKAQAKTASELSKSMETMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGERDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHIEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHAASKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTSRSMQNYVQFLKSSYANVFGDGPYASYLTSSPIRSRSPPT", "length": 824, "header": "tr|F1MU43-1|A0A3Q1M355_BOVIN Computationally mapped isoform of Outer dense fiber protein 2 OS=Bos taurus OX=9913 GN=ODF2 PE=3 SV=4 CANONICAL=A0A3Q1M355-1" }, "locus": { "chromosome": "11", "start_pos": 99062569, "end_pos": 99038906, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020325.8", "url": "https://www.ensembl.org/id/ENSBTAT00000020325.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020325.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020325.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2565942", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "resource": "Reactome", "description": "Regulation of PLK1 Activity at G2/M Transition" }, { "id": "R-BTA-380259", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "resource": "Reactome", "description": "Loss of Nlp from mitotic centrosomes" }, { "id": "R-BTA-380270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "resource": "Reactome", "description": "Recruitment of mitotic centrosome proteins and complexes" }, { "id": "R-BTA-380284", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "resource": "Reactome", "description": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "id": "R-BTA-380320", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "resource": "Reactome", "description": "Recruitment of NuMA to mitotic centrosomes" }, { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-BTA-8854518", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "resource": "Reactome", "description": "AURKA Activation by TPX2" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AJR2-1", "protein_name": "Outer dense fiber protein 2", "gene_name": "ODF2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLLKDSTCFDQNWPLLLSGTEGNVVISSFLIHRFPFIVFSFPVCGRRAMKNRSSSPPLHVHVDENTPVHVHIKKGQKTTPAKCQVGVCSWVFVRAAGRRQSWKHHGIFEQKHKQKMKGNTVNVRRAVQVKTKAPWMPPGKTSVLDSTYKWEGPTHRLEITPPESEKMMSVLRLSDLSTDEEDAVCCKMNEYERKIDSLMNVVGTLKNEAKLQKQEQRQQMTKRLLEEQKEELNEVTQELAESEHENTLLRRNIERMREEKDLTMLQKKYLQHEKECLLSKLSEAERDGAAAAREIHALKSTIERLSVEKHMSSSDINMLTRQKELLLQKLSTFEETNRTLRELLREQHERERDVQKILEKQGVLMKMLADSDAEKLQLQMRLQDKEKEINNLAVQIQEEKEQARTASELSKSLESVRGHLQAQLRHKEAENNRLTTQIRNLERSEAQHKAEVECIKDQLKELRQKADRDKDALKRALRAQKERAERSEECAGQLAVQLAEKDSYVAEALSTLESWRSRYNKVVKDKSDLELEMVTVNSRIADLLEQQATLEDKMREDRDALMDKLHQQTTETTSFRMENERLKASVVPMEEKLNQAHVEVQQLKSSVRNYEDLIETYKSQVLKTRMEAADVAAKLEKCDNEKKALKDEMNKELELARKQFQSQLAELEKLPEILRITETQLAECQDQLQSYEKKNMDLSVMIADLRQRIELQGDKMEMTRERYQSAQEEKKQLTLKAEELERKLETTSTQNIEFLQVIAKREESIHQCQLRLEEKTRECSSLARQLEMAIEDAKRQVEQTRERATSRERAAQSKVLDLETQLSRTKTELNQLRRNKEDAERRYESRLQDLKDRLEQSESTNRSMQNYVQFLKSSYANVFADSALLGSPGRSRSSP", "length": 895 }, "evidence": [ { "id": "A0A3Q1M355", "url": "https://omabrowser.org/oma/group/A0A3Q1M355/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A3KGV1-1", "protein_name": "Outer dense fiber protein 2", "gene_name": "Odf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"common_name": "Mouse" }, { "uniprot_canonical_ac": "E7F186-1", "protein_name": "Outer dense fiber protein 2", "gene_name": "odf2a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": 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"common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5BJF6-1", "protein_name": "Outer dense fiber protein 2", "gene_name": "ODF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSASSSGGSPRFPSCGKNGVTSLTQKKVLRAPCGAPSVTVTKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARPVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSYANVFGDGPYSTFLTSSPIRSRSPPA", "length": 829 }, "evidence": [ { "id": "A0A3Q1M355", "url": "https://omabrowser.org/oma/group/A0A3Q1M355/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6AYX5-1", "protein_name": "Outer dense fiber protein 2", "gene_name": "Odf2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKDRSSTPPLHVHVDENTPVHVHIKKLPKPSAASSQKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLELAREKHQASQKENKQLSQKVDELERKLEATSTQNVEFLQVIAKREEAIHQAQLRLEEKTRECGSLARQLESAIEDARRQVEQTKEQALSKERAAQSKILDLETQLSRTKTELGQLRRTRDDVDRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSYANVFGDGPYTSSYLTSSPIRSRSPPA", "length": 825 }, "evidence": [ { "id": "A0A3Q1M355", "url": "https://omabrowser.org/oma/group/A0A3Q1M355/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M355", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M355", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M355", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M355", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M355", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M355", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M355", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355" } ], "pmid": "" }, { "name": "ciliary transition fiber", "id": "GO:0097539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097539", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M355", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M355", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M355", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355" } ], "pmid": "" }, { "name": "regulation of cilium assembly", "id": "GO:1902017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902017", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M355", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M355" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 269, "end_pos": 271 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M2S7-1", "uniprot_ac": "A0A3Q1M2S7", "uniprot_id": "A0A3Q1M2S7_BOVIN", "mass": { "chemical_mass": 125865.0, "monoisotopic_mass": 125865.0 }, "refseq": { "ac": "XP_005211552", "name": "solute carrier family 12 member 6 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211552" }, "gene_names": [ { "name": "SLC12A6", "type": "recommended", "evidence": [ { "id": "A0A3Q1M2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ] }, { "name": "SLC12A6", "type": "synonym", "evidence": [ { "id": "XP_005211552", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211552" } ] } ], "protein_names": [ { "name": "Solute carrier family 12 member 6", "type": "synonym", "evidence": [ { "id": "A0A3Q1M2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 12 member 6 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005211552", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211552" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC12A6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7", "locus": { "chromosome": "10", "start_pos": 28385780, "end_pos": 28304552, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016236", "url": "https://www.ensembl.org/id/ENSBTAG00000016236" } ] } } ], "crossref": [ { "id": "A0A3Q1M2S7", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M2S7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016236", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016236", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "521217", "url": "https://www.ncbi.nlm.nih.gov/gene/521217", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000076", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000076", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000622", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000622", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018491", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018491", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521217", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521217", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GDICARK", "url": "https://omabrowser.org/oma/group/GDICARK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVU6", "url": "https://www.orthodb.org/?gene=A0A3Q1LVU6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2S7", "url": "https://www.orthodb.org/?gene=A0A3Q1M2S7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N2X1", "url": "https://www.orthodb.org/?gene=F1N2X1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11827", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11827:SF66", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF66", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00324", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00324", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03522", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03522", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-426117", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-426117", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005211552", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211552", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "72427", "url": "https://www.rhea-db.org/rhea/72427", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LVU6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVU6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVU6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2S7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7N6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7N6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGF4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGD9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGD9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2X1", "url": "https://www.uniprot.org/uniprotkb/F1N2X1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N2X1-1", "url": "https://www.uniprot.org/uniprotkb/F1N2X1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDQASDRTSNPQDVTEDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLSRLANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFQSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEVNNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGVITENLWSNYLPKGEIIEKPSAKSSEVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFSQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDDETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS", "length": 1135, "header": "tr|A0A3Q1M2S7-1|A0A3Q1M2S7_BOVIN Isoform 1 of Solute carrier family 12 member 6 OS=Bos taurus OX=9913 GN=SLC12A6 PE=3 SV=1 CANONICAL=A0A3Q1M2S7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVU6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVU6/entry", "sequence": { "sequence": "MPHFTVTKVEDTEEGAAAPVSQEGEPSLAEIKAPIQHSDEPGIFHDSPGGIHLNELLFDPSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLSRLANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFQSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEVNNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGVITENLWSNYLPKGEIIEKPSAKSSEVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFSQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDDETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS", "length": 1118, "header": "tr|A0A3Q1LVU6-1|A0A3Q1M2S7_BOVIN Computationally mapped isoform of Solute carrier family 12 member 6 OS=Bos taurus OX=9913 GN=SLC12A6 PE=3 SV=2 CANONICAL=A0A3Q1M2S7-1" }, "locus": { "chromosome": "10", "start_pos": 28385535, "end_pos": 28325802, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069382.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069382.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061552.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061552.2" } ] } }, { "isoform_ac": "A0A3Q1M2S7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7/entry", "sequence": { "sequence": "MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDQASDRTSNPQDVTEDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLSRLANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFQSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEVNNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGVITENLWSNYLPKGEIIEKPSAKSSEVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFSQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDDETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS", "length": 1135, "header": "tr|A0A3Q1M2S7-1|A0A3Q1M2S7_BOVIN Isoform 1 of Solute carrier family 12 member 6 OS=Bos taurus OX=9913 GN=SLC12A6 PE=3 SV=1 CANONICAL=A0A3Q1M2S7-1" }, "locus": { "chromosome": "10", "start_pos": 28385535, "end_pos": 28304751, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071407.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071407.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062421.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062421.1" } ] } }, { "isoform_ac": "A0AAA9S7N6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N6/entry", "sequence": { "sequence": "MPHFTVTKVEDTEEGAAAPVSQEGEPSLAEIKAPIQHSDEPDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLSRLANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFQSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEVNNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGVITENLWSNYLPKGEIIEKPSAKSSEVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFSQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDDETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS", "length": 1086, "header": "tr|A0AAA9S7N6-1|A0A3Q1M2S7_BOVIN Computationally mapped isoform of Solute carrier family 12 member 6 OS=Bos taurus OX=9913 GN=SLC12A6 PE=3 SV=1 CANONICAL=A0A3Q1M2S7-1" }, "locus": { "chromosome": "10", "start_pos": 28385535, "end_pos": 28325802, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133143.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133143.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079945.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079945.1" } ] } }, { "isoform_ac": "A0AAA9SGF4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGF4/entry", "sequence": { "sequence": "MDTRPKVSSLLSRLANYTNLTQGAKEHEEAENITEGKKKPTKTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFQSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEVNNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGVITENLWSNYLPKGEIIEKPSAKSSEVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFSQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDDETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS", "length": 962, "header": "tr|A0AAA9SGF4-1|A0A3Q1M2S7_BOVIN Computationally mapped isoform of Solute carrier family 12 member 6 OS=Bos taurus OX=9913 GN=SLC12A6 PE=3 SV=1 CANONICAL=A0A3Q1M2S7-1" }, "locus": { "chromosome": "10", "start_pos": 28385535, "end_pos": 28364428, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118584.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118584.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084445.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084445.1" } ] } }, { "isoform_ac": "A0AAA9TGD9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGD9/entry", "sequence": { "sequence": "MPHFTVTKVEDTEEGAAAPVSQEGEPSLAEIKAPIQHSDEPDPSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLSRLANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFQSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEVNNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGVITENLWSNYLPKGEIIEKPSAKSSEVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFSQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDDETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS", "length": 1101, "header": "tr|A0AAA9TGD9-1|A0A3Q1M2S7_BOVIN Computationally mapped isoform of Solute carrier family 12 member 6 OS=Bos taurus OX=9913 GN=SLC12A6 PE=3 SV=1 CANONICAL=A0A3Q1M2S7-1" }, "locus": { "chromosome": "10", "start_pos": 28385535, "end_pos": 28325802, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112863.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112863.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097625.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097625.1" } ] } }, { "isoform_ac": "F1N2X1-1", "url": "https://www.uniprot.org/uniprotkb/F1N2X1/entry", "sequence": { "sequence": "MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDQASDRTSNPQDVTEDPSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLSRLANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFQSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEVNNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGVITENLWSNYLPKGEIIEKPSAKSSEVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFSQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDDETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS", "length": 1150, "header": "tr|F1N2X1-1|A0A3Q1M2S7_BOVIN Computationally mapped isoform of Solute carrier family 12 member 6 OS=Bos taurus OX=9913 GN=SLC12A6 PE=3 SV=2 CANONICAL=A0A3Q1M2S7-1" }, "locus": { "chromosome": "10", "start_pos": 28385535, "end_pos": 28304751, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021604.8", "url": "https://www.ensembl.org/id/ENSBTAT00000021604.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021604.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021604.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:521217", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521217", "resource": "KEGG Pathway" }, { "id": "R-BTA-426117", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-426117", "resource": "Reactome", "description": "Cation-coupled Chloride cotransporters" } ], "orthologs": [ { "uniprot_canonical_ac": "G3HIG7-1", "protein_name": "Solute carrier family 12 member 6 isoform X1", "gene_name": "Slc12a6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MHPPEPTTKMSSVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSELSGATTSLATVALDPSSDRTSNPQDVTEDPNQNSITGEHSQLLDDGHKKARNAYLSNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKSPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFRTDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHLDVCSKTKDINNMTMPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLLKGEIIEKPSARSSDVLGSLNHEYVLADITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTVLAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLKEGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNVSFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQRVKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS", "length": 1150 }, "evidence": [ { "id": "A0A3Q1M2S7", "url": "https://omabrowser.org/oma/group/A0A3Q1M2S7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3V6N7-1", "protein_name": "Solute carrier family 12, member 6", "gene_name": "Slc12a6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHPPETTTKMSSVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSELSGATTSLATVALDPSSDRTSNPQDVTEDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKSPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFRSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHLDICSKTKEVNNMTIPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGNLNHEYVLADITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPHWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGDALAAEQTIKHLMEAEKVKGFCQLVVAAKLKEGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNVSFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKVKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS", "length": 1135 }, "evidence": [ { "id": "A0A3Q1M2S7", "url": "https://omabrowser.org/oma/group/A0A3Q1M2S7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q924N4-1", "protein_name": "Solute carrier family 12 member 6", "gene_name": "Slc12a6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHPPEATTKMSSVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSELSGATTSLATVALDPSSDRTSNPQDVTEDPSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKSPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGILQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFRSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHLDICSKTKEVDNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVISIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGNLNHEYVLADITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGDALAAEQTIKHLMEAEKVKGFCQLVVAAKLKEGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNVSFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKVKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS", "length": 1150 }, "evidence": [ { "id": "A0A3Q1M2S7", "url": "https://omabrowser.org/oma/group/A0A3Q1M2S7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UHW9-1", "protein_name": "Solute carrier family 12 member 6", "gene_name": "SLC12A6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHPPETTTKMASVRFMVTPTKIDDIPGLSDTSPDLSSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS", "length": 1150 }, "evidence": [ { "id": "A0A3Q1M2S7", "url": "https://omabrowser.org/oma/group/A0A3Q1M2S7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "potassium:chloride symporter activity", "id": "GO:0015379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015379", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "cellular response to glucose stimulus", "id": "GO:0071333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071333", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "pmid": "" }, { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "pmid": "" }, { "name": "cell volume homeostasis", "id": "GO:0006884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006884", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "pmid": "" }, { "name": "chloride transmembrane transport", "id": "GO:1902476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902476", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "pmid": "" }, { "name": "potassium ion homeostasis", "id": "GO:0055075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055075", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "pmid": "" }, { "name": "potassium ion import across plasma membrane", "id": "GO:1990573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990573", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "pmid": "" }, { "name": "chloride ion homeostasis", "id": "GO:0055064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055064", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "pmid": "" }, { "name": "cellular hypotonic salinity response", "id": "GO:0071477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071477", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2S7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1081, "end_pos": 1083, "annotation": "n_glycosylation_sequon" }, { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 364, "end_pos": 366, "annotation": "n_glycosylation_sequon" }, { "start_pos": 383, "end_pos": 385, "annotation": "n_glycosylation_sequon" }, { "start_pos": 396, "end_pos": 398, "annotation": "n_glycosylation_sequon" }, { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" }, { "start_pos": 413, "end_pos": 415, "annotation": "n_glycosylation_sequon" }, { "start_pos": 489, "end_pos": 491, "annotation": "n_glycosylation_sequon" }, { "start_pos": 880, "end_pos": 882, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "72427", "name": "", "equation": "K(+)(in) + chloride(in) = K(+)(out) + chloride(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "72427", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/72427" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" }, { "id": "PF00324", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00324" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amino acid permease/ SLC12A", "eco_id": "ECO_0000259", "start_pos": 176, "end_pos": 348, "start_aa": "Val", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1M2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2S7" }, { "id": "PF03522", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03522" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SLC12A transporter C-terminal", "eco_id": "ECO_0000259", "start_pos": 759, "end_pos": 877, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 1081, "end_pos": 1083 }, { "start_pos": 140, "end_pos": 142 }, { "start_pos": 143, "end_pos": 145 }, { "start_pos": 156, "end_pos": 158 }, { "start_pos": 364, "end_pos": 366 }, { "start_pos": 383, "end_pos": 385 }, { "start_pos": 396, "end_pos": 398 }, { "start_pos": 402, "end_pos": 404 }, { "start_pos": 413, "end_pos": 415 }, { "start_pos": 489, "end_pos": 491 }, { "start_pos": 880, "end_pos": 882 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M089-1", "uniprot_ac": "A0A3Q1M089", "uniprot_id": "A0A3Q1M089_BOVIN", "mass": { "chemical_mass": 73819.0, "monoisotopic_mass": 73819.0 }, "refseq": {}, "gene_names": [ { "name": "SLC2A12", "type": "recommended", "evidence": [ { "id": "A0A3Q1M089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M089" } ] } ], "protein_names": [ { "name": "Solute carrier family 2, facilitated glucose transporter member 12", "type": "recommended", "evidence": [ { "id": "A0A3Q1M089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M089/entry#names_and_taxonomy" } ] }, { "name": "Glucose transporter type 12", "type": "synonym", "evidence": [ { "id": "A0A3Q1M089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M089/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Insulin-independent facilitative glucose transporter.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M089", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M089#function" }, { "database": "UniProtKB", "id": "ARBA00053786", "url": "https://www.uniprot.org/uniprotkb/ARBA00053786#function" }, { "database": "UniProtKB", "id": "A0AAA9STV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV4#function" }, { "database": "UniProtKB", "id": "A0AAA9TNF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNF7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M089", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M089" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC2A12", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M089", "locus": { "chromosome": "9", "start_pos": 72148001, "end_pos": 72223688, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019002", "url": "https://www.ensembl.org/id/ENSBTAG00000019002" } ] } } ], "crossref": [ { "id": "A0A3Q1M089", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M089", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019002", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019002", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17435", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17435", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "497031", "url": "https://www.ncbi.nlm.nih.gov/gene/497031", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003663", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003663", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005829", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005829", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050820", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050820", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M089", "url": "https://www.orthodb.org/?gene=A0A3Q1M089", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MIV2", "url": "https://www.orthodb.org/?gene=F1MIV2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48023", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48023", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48023:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48023:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00083", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00083", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-189200", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-189200", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "60376", "url": "https://www.rhea-db.org/rhea/60376", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M089", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M089", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M089-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M089-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STV4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNF7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNF7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIV2", "url": "https://www.uniprot.org/uniprotkb/F1MIV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIV2-1", "url": "https://www.uniprot.org/uniprotkb/F1MIV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVPVENAEGPSLLKPKGRAAETDGSDRASGGPHPPWARGCGMYTLLSSVTAAVSGFLVGYELGIISGALLQIRTLLVLTCHEQEMVVSSLLIGALLASLIGGVLIDRYGRRAAIILSSCLLGLGSLVLIISLSYTTLIGGRIAIGVFISLSSTATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANISHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLGKLRAISDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLMLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDQVGSKTFLCIGSSVMAASLVTMGIVNLNIHMNFTSICRNHSPINQSLDESVFYGPGNLSASNDTLRESFKGMTFHSRSSLRPTRNDINGKGETTLASLPNAGLSQTEYRIVTDSADVPTFLKWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTVMSLASLVFVIVFIPETKGCSLEQISVELAKENYVKNNICFMSHHREELVPKQLQKRKPQEQFLESKKLRGELMKKDLQPPFCTVHFSRKLEHALFICSGRRESMFCRGNRLKKFIKNLQWNYMLTLKKVKTGN", "length": 673, "header": "tr|A0A3Q1M089-1|A0A3Q1M089_BOVIN Isoform 1 of Solute carrier family 2, facilitated glucose transporter member 12 OS=Bos taurus OX=9913 GN=SLC2A12 PE=3 SV=2 CANONICAL=A0A3Q1M089-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M089-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M089/entry", "sequence": { "sequence": "MVPVENAEGPSLLKPKGRAAETDGSDRASGGPHPPWARGCGMYTLLSSVTAAVSGFLVGYELGIISGALLQIRTLLVLTCHEQEMVVSSLLIGALLASLIGGVLIDRYGRRAAIILSSCLLGLGSLVLIISLSYTTLIGGRIAIGVFISLSSTATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANISHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLGKLRAISDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLMLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDQVGSKTFLCIGSSVMAASLVTMGIVNLNIHMNFTSICRNHSPINQSLDESVFYGPGNLSASNDTLRESFKGMTFHSRSSLRPTRNDINGKGETTLASLPNAGLSQTEYRIVTDSADVPTFLKWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTVMSLASLVFVIVFIPETKGCSLEQISVELAKENYVKNNICFMSHHREELVPKQLQKRKPQEQFLESKKLRGELMKKDLQPPFCTVHFSRKLEHALFICSGRRESMFCRGNRLKKFIKNLQWNYMLTLKKVKTGN", "length": 673, "header": "tr|A0A3Q1M089-1|A0A3Q1M089_BOVIN Isoform 1 of Solute carrier family 2, facilitated glucose transporter member 12 OS=Bos taurus OX=9913 GN=SLC2A12 PE=3 SV=2 CANONICAL=A0A3Q1M089-1" }, "locus": { "chromosome": "9", "start_pos": 72223315, "end_pos": 72153144, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081910.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081910.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063361.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063361.2" } ] } }, { "isoform_ac": "A0AAA9STV4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STV4/entry", "sequence": { "sequence": "MGKVTARVSWGSRGGLGPSLLKPKGRAAETDGSDRASGGPHPPWARGCGMYTLLSSVTAAVSGFLVGYELGIISGALLQIRTLLVLTCHEQEMVVSSLLIGALLASLIGGVLIDRYGRRAAIILSSCLLGLGSLVLIISLSYTTLIGGRIAIGVFISLSSTATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANISHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLGKLRAISDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLMLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDQVGSKTFLCIGSSVMAASLVTMGIVNLNIHMNFTSICRNHSPINQSLDESVFYGPGNLSASNDTLRESFKGMTFHSRSSLRPTRNDINGKGETTLASLPNAGLSQTEYRIVTDSADVPTFLKWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTVMSLASLVFVIVFIPETKGCSLEQISVELAKENYVKNNICFMSHHREELVPKQLQKRKPQEQFLESKKLRGKGQPRQLSSEV", "length": 629, "header": "tr|A0AAA9STV4-1|A0A3Q1M089_BOVIN Computationally mapped isoform of Solute carrier family 2, facilitated glucose transporter member 12 OS=Bos taurus OX=9913 GN=SLC2A12 PE=3 SV=1 CANONICAL=A0A3Q1M089-1" }, "locus": { "chromosome": "9", "start_pos": 72223397, "end_pos": 72154878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115153.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115153.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089855.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089855.1" } ] } }, { "isoform_ac": "A0AAA9TNF7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNF7/entry", "sequence": { "sequence": "MVPVENAEGPSLLKPKGRAAETDGSDRASGGPHPPWARGCGMYTLLSSVTAAVSGFLVGYELGIISGALLQIRTLLVLTCHEQEMVVSSLLIGALLASLIGGVLIDRYGRRAAIILSSCLLGLGSLVLIISLSYTTLIGGRIAIGVFISLSSTATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANISHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLGKLRAISDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLMLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDQVGSKTFLCIGSSVMAASLVTMGIVNLNIHMNFTSICRNHSPINQSLDESVFYGPGNLSASNDTLRESFKGMTFHSRSSLRPTRNDINGKGETTLASLPNAGLSQTEYRIVTDSADVPTFLKWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTVMSLASLVFVIVFIPETKGCSLEQISVELAKENYVKNNICFMSHHREELVPKQLQKRKPQEQFLESKKLRGWT", "length": 612, "header": "tr|A0AAA9TNF7-1|A0A3Q1M089_BOVIN Computationally mapped isoform of Solute carrier family 2, facilitated glucose transporter member 12 OS=Bos taurus OX=9913 GN=SLC2A12 PE=3 SV=1 CANONICAL=A0A3Q1M089-1" }, "locus": { "chromosome": "9", "start_pos": 72223315, "end_pos": 72148918, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101279.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101279.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100060.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100060.1" } ] } }, { "isoform_ac": "F1MIV2-1", "url": "https://www.uniprot.org/uniprotkb/F1MIV2/entry", "sequence": { "sequence": "MVPVENAEGPSLLKPKGRAAETDGSDRASGGPHPPWARGCGMYTLLSSVTAAVSGFLVGYELGIISGALLQIRTLLVLTCHEQEMVVSSLLIGALLASLIGGVLIDRYGRRAAIILSSCLLGLGSLVLIISLSYTTLIGGRIAIGVFISLSSTATCVYIAEIAPQHRRGLLVSLNELMIVIGILFAYISNYAFANISHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGHEEAASKVLGKLRAISDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLMLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDQVGSKTFLCIGSSVMAASLVTMGIVNLNIHMNFTSICRNHSPINQSLDESVFYGPGNLSASNDTLRESFKGMTFHSRSSLRPTRNDINGKGETTLASLPNAGLSQTEYRIVTDSADVPTFLKWLSLASLLVYVAAFSIGLGPNLIGLPWVCFIYTVMSLASLVFVIVFIPETKGCSLEQISVELAKENYVKNNICFMSHHREELVPKQLQKRKPQEQFLESKKLRGKGQPRQLSSEV", "length": 580, "header": "tr|F1MIV2-1|A0A3Q1M089_BOVIN Computationally mapped isoform of Solute carrier family 2, facilitated glucose transporter member 12 OS=Bos taurus OX=9913 GN=SLC2A12 PE=3 SV=2 CANONICAL=A0A3Q1M089-1" }, "locus": { "chromosome": "9", "start_pos": 72223315, "end_pos": 72154878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025291.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025291.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025291.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025291.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-189200", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-189200", "resource": "Reactome", "description": "Cellular hexose transport" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "circulatory system development", "id": "GO:0072359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072359", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M089", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M089" } ], "pmid": "" }, { "name": "D-glucose transmembrane transport", "id": "GO:1904659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904659", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M089", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M089" } ], "pmid": "" }, { "name": "hexose transmembrane transport", "id": "GO:0008645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008645", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M089", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M089" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M089", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M089" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M089", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M089" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", 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"database": "Ensembl Transcript", "id": "ENSBTAT00000124299.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124299.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100900.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100900.1" } ] } }, { "isoform_ac": "F6QGZ0-1", "url": "https://www.uniprot.org/uniprotkb/F6QGZ0/entry", "sequence": { "sequence": "MAHRRQALPVGQHVSTRSPRPPPPGAGGDKPGPGKGCVGEAGSAGQGATAPGLSLGQVCPWDRTVSVGAGLRGSRSGVGGGPWRVGSMTALQLKELSQSGLYRRRRDRPDSLRLPGQREEVLSNMANALANASCERCRGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDVVSALNKAWCVHCFACSTCSAKLTLKNKFVEFDMKPVCKKCYEKFPLELKKRLKKLAETLGRK", "length": 449, "header": "tr|F6QGZ0-1|A0A3Q1LXS3_BOVIN Computationally mapped isoform of LIM and senescent cell antigen-like-containing domain protein OS=Bos taurus OX=9913 GN=LIMS1 PE=4 SV=1 CANONICAL=A0A3Q1LXS3-1" }, "locus": { "chromosome": "11", "start_pos": 44746371, "end_pos": 44716351, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014566.6", "url": "https://www.ensembl.org/id/ENSBTAT00000014566.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014566.5", "url": "https://www.ensembl.org/id/ENSBTAP00000014566.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-446343", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446343", "resource": "Reactome", "description": "Localization of the PINCH-ILK-PARVIN complex to focal adhesions" }, { "id": "R-BTA-446353", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446353", "resource": "Reactome", "description": "Cell-extracellular matrix interactions" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS3" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS3" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS3" } ], "pmid": "" } ] }, { "name": 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{ "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS3" } ], "pmid": "" }, { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS3" } ], "pmid": "" }, { "name": "actin filament bundle assembly", "id": "GO:0051017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051017", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS3" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS3" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS3" } ], "pmid": "" }, { "name": "cellular response to transforming growth factor beta stimulus", "id": "GO:0071560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071560", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS3" } ], "pmid": "" }, { "name": "actin filament network formation", "id": "GO:0051639", "url": 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"common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMSB4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXR1", "locus": {} } ], "crossref": [ { "id": "A0A3Q1LXR1", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LXR1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051079", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051079", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "101906565", "url": "https://www.ncbi.nlm.nih.gov/gene/101906565", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038386", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038386", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12021", "url": 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"sequence": { "sequence": "MKLKQSVLTIILLPIHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKESLGTREVLSEENEMQPNGKVFKKLILGNYKWLNYLEVNRRVNNFGSGLTALGLKPKSTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGREAVVHGLNESEATYLITSVELLESKLKTALIDINCVKHIIYVDNKTINKAEYPEGFEIHSMQSVEELGSKPENLSVSPNRPTPSDLAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLILFKKVKALLGGNVRMMLSGGAPLSPQTQRFMNVCFCCPVGQGYGLTETCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTIHDKPNPRGEIVIGGKNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQQKLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANTMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELKNHYLKDIERMYGGK", "length": 711, "header": "tr|A0A3Q1LZ55-1|A0A3Q1LZ55_BOVIN Isoform 1 of long-chain-fatty-acid--CoA ligase OS=Bos taurus OX=9913 GN=ACSL4 PE=3 SV=1 CANONICAL=A0A3Q1LZ55-1" }, "locus": { "chromosome": "X", "start_pos": 58066702, "end_pos": 58035382, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070050.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070050.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060970.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060970.1" } ] } }, { "isoform_ac": "A0AAA9TAL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAL4/entry", "sequence": { "sequence": "MAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKESLGTREVLSEENEMQPNGKVFKKLILGNYKWLNYLEVNRRVNNFGSGLTALGLKPKSTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGREAVVHGLNESEATYLITSVELLESKLKTALIDINCVKHIIYVDNKTINKAEYPEGFEIHSMQSVEELGSKPENLSVSPNRPTPSDLAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLILFKKVKALLGGNVRMMLSGGAPLSPQTQRFMNVCFCCPVGQGYGLTETCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTIHDKPNPRGEIVIGGKNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQQKLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANTMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELKNHYLKDIERMYGGK", "length": 670, "header": "tr|A0AAA9TAL4-1|A0A3Q1LZ55_BOVIN Computationally mapped isoform of long-chain-fatty-acid--CoA ligase OS=Bos taurus OX=9913 GN=ACSL4 PE=3 SV=1 CANONICAL=A0A3Q1LZ55-1" }, "locus": { "chromosome": "X", "start_pos": 58066579, "end_pos": 58035382, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122507.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122507.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093927.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093927.1" } ] } }, { "isoform_ac": "F1MBW3-1", "url": "https://www.uniprot.org/uniprotkb/F1MBW3/entry", "sequence": { "sequence": "MRARARKGIFNMAAEVLSLLGKAGKRLAGWRLQELISIQKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKESLGTREVLSEENEMQPNGKVFKKLILGNYKWLNYLEVNRRVNNFGSGLTALGLKPKSTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGREAVVHGLNESEATYLITSVELLESKLKTALIDINCVKHIIYVDNKTINKAEYPEGFEIHSMQSVEELGSKPENLSVSPNRPTPSDLAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLILFKKVKALLGGNVRMMLSGGAPLSPQTQRFMNVCFCCPVGQGYGLTETCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTIHDKPNPRGEIVIGGKNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQQKLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANTMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELKNHYLKDIERMYGGK", "length": 713, "header": "tr|F1MBW3-1|A0A3Q1LZ55_BOVIN Computationally mapped isoform of long-chain-fatty-acid--CoA ligase OS=Bos taurus OX=9913 GN=ACSL4 PE=3 SV=3 CANONICAL=A0A3Q1LZ55-1" }, "locus": { "chromosome": "X", "start_pos": 58076456, "end_pos": 58035382, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054636.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054636.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050572.4", "url": "https://www.ensembl.org/id/ENSBTAP00000050572.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 268, "start_aa": "Thr", "end_pos": 268, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr268", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:536628", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536628", "resource": "KEGG Pathway" }, { "id": "R-BTA-434313", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-434313", "resource": "Reactome", "description": "Intracellular metabolism of fatty acids regulates insulin secretion" }, { "id": "R-BTA-75876", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75876", "resource": "Reactome", "description": "Synthesis of very long-chain fatty acyl-CoAs" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YSN7-1", "protein_name": "long-chain-fatty-acid--CoA ligase", "gene_name": "ACSL4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKLRLEVCAILLLPVYLLISVYSMLVFIPWYFLTNAKKKKAMAKRLKAKPISDKPGSPYRSVTHLDSLANINIPGADTLDKLFDHALAKFGKKDCLGTREILSEENEMQPNGKVFKKLILGTYRWLSYEEVNQKVNRLGSGLIALGLTPKSTVVIFCETRAEWMIAALACFKYNFPLVTLYATLGEEAVTYGLNECGASYLITSAELLESKLKATLPHISCLKHIIYVDNKTINKSEYPENVEIHSMQTVEELGAKPENASIQPSRPVPTDLALVMYTSGSTGRPKGVMMQHKNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCITYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQRTLFKIGYDYKLEQIKRGYDAPLCNILLFKKVKALLGGNIRMMLSGGAPLSPQTQRFMNICFCCPVGQGYGLTETCGAGTITEVADYSTGRVGAPLICCEIRLRDWQEGGYTNRDKPNPRGEIIIGGPNVSMGYFKNEEKTTEDFTIDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCSLIDNICAYAKSDQSYVISFVVPNQKKLTALAEQKGISGTWVEICNNPTMEAEILQEIKEVANKMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELKNHYLNDIERMYGGK", "length": 711 }, "evidence": [ { "id": "A0A3Q1LZ55", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ55/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O35547-1", "protein_name": "Long-chain-fatty-acid--CoA ligase 4", "gene_name": "Acsl4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKLKLNVLTIVLLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVAKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWINYLEVNCRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKAALLDINCVKHIIYVDNKTINRAEYPEGLEIHSMQSVEELGSKPENSSIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLILFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTVHDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKKLTLLAQQKGVEGSWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELKNHYLKDIERMYGGK", "length": 711 }, "evidence": [ { "id": "A0A3Q1LZ55", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ55/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O60488-1", "protein_name": "Long-chain-fatty-acid--CoA ligase 4", "gene_name": "ACSL4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEGFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTINDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKRLTLLAQQKGVEGTWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELRNHYLKDIERMYGGK", "length": 711 }, "evidence": [ { "id": "A0A3Q1LZ55", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ55/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P47912-1", "protein_name": "Long-chain-fatty-acid--CoA ligase 4", "gene_name": "FAA4", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTEQYSVAVGEAANEHETAPRRNIRVKDQPLIRPINSSASTLYEFALECFTKGGKRDGMAWRDIIDIHETKKTIVKRVDGKDKPIEKTWLYYELTPYITMTYEEMICVMHDIGRGLIKIGVKPNGENKFHIFASTSHKWMKTFLGCMSQGIPVVTAYDTLGESGLIHSMVETDSVAIFTDNQLLSKLAVPLKTAKNVKFVIHNEPIDPSDKRQNGKLYKAAKDAVDKIKEVRPDIKIYSFDEIIEIGKKAKDEVELHFPKPEDPACIMYTSGSTGTPKGVVLTHYNIVAGIGGVGHNVIGWIGPTDRIIAFLPLAHIFELTFEFEAFYWNGILGYANVKTLTPTSTRNCQGDLMEFKPTVMVGVAAVWETVRKGILAKINELPGWSQTLFWTVYALKERNIPCSGLLSGLIFKRIREATGGNLRFILNGGSAISIDAQKFLSNLLCPMLIGYGLTEGVANACVLEPEHFDYGIAGDLVGTITAKLVDVEDLGYFAKNNQGELLFKGAPICSEYYKNPEETAAAFTDDGWFRTGDIAEWTPKGQVKIIDRKKNLVKTLNGEYIALEKLESIYRSNPYVQNICVYADENKVKPVGIVVPNLGHLSKLAIELGIMVPGEDVESYIHEKKLQDAVCKDMLSTAKSQGLNGIELLCGIVFFEEEWTPENGLVTSAQKLKRRDILAAVKPDVERVYKENT", "length": 694 }, "evidence": [ { "id": "A0A3Q1LZ55", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ55/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q9CAP8-1", "protein_name": "Long chain acyl-CoA synthetase 9, chloroplastic", "gene_name": "LACS9", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MIPYAAGVIVPLALTFLVQKSKKEKKRGVVVDVGGEPGYAIRNHRFTEPVSSHWEHISTLPELFEISCNAHSDRVFLGTRKLISREIETSEDGKTFEKLHLGDYEWLTFGKTLEAVCDFASGLVQIGHKTEERVAIFADTREEWFISLQGCFRRNVTVVTIYSSLGEEALCHSLNETEVTTVICGSKELKKLMDISQQLETVKRVICMDDEFPSDVNSNWMATSFTDVQKLGRENPVDPNFPLSADVAVIMYTSGSTGLPKGVMMTHGNVLATVSAVMTIVPDLGKRDIYMAYLPLAHILELAAESVMATIGSAIGYGSPLTLTDTSNKIKKGTKGDVTALKPTIMTAVPAILDRVRDGVRKKVDAKGGLSKKLFDFAYARRLSAINGSWFGAWGLEKLLWDVLVFRKIRAVLGGQIRYLLSGGAPLSGDTQRFINICVGAPIGQGYGLTETCAGGTFSEFEDTSVGRVGAPLPCSFVKLVDWAEGGYLTSDKPMPRGEIVIGGSNITLGYFKNEEKTKEVYKVDEKGMRWFYTGDIGRFHPDGCLEIIDRKKDIVKLQHGEYVSLGKVEAALSISPYVENIMVHADSFYSYCVALVVASQHTVEGWASKQGIDFANFEELCTKEQAVKEVYASLVKAAKQSRLEKFEIPAKIKLLASPWTPESGLVTAALKLKRDVIRREFSEDLTKLYA", "length": 691 }, "evidence": [ { "id": "A0A3Q1LZ55", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ55/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9QUJ7-1", "protein_name": "Long-chain-fatty-acid--CoA ligase 4", "gene_name": "Acsl4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVAKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWINYLEVNCRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGREAVVHGLNESEASYLITSVELLESKLKAALVDINCVKHIIYVDNKTINRAEYPEGLEIHSMQSVEELGAKPENLSVPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYVQKTLFKIGYDYKLEQIKKGYDAPLCNLILFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTVHDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYCVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKKLTLLAQQKGVEGSWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELKNHYLKDIERMYGGK", "length": 711 }, "evidence": [ { "id": "A0A3Q1LZ55", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ55/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "long-chain fatty acid metabolic process", "id": "GO:0001676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001676", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ], "pmid": "" }, { "name": "long-chain fatty-acyl-CoA metabolic process", "id": "GO:0035336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035336", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ], "pmid": "" }, { "name": "fatty acid biosynthetic process", "id": "GO:0006633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006633", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ], "pmid": "" }, { "name": "positive regulation of ferroptosis", "id": "GO:0160020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ], "pmid": "" }, { "name": "mitochondria-associated endoplasmic reticulum membrane contact site", "id": "GO:0044233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044233", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "arachidonate-CoA ligase activity", "id": "GO:0047676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047676", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ], "pmid": "" }, { "name": "long-chain fatty acid-CoA ligase activity", "id": "GO:0004467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004467", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ], "pmid": "" }, { "name": "very long-chain fatty acid-CoA ligase activity", "id": "GO:0031957", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031957", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ55", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 230, "end_pos": 232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 525, "end_pos": 527, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15421", "name": "", "equation": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LZ55-1", "E1BCN4-1", "A0A3Q1LVU8-1", "A0A3Q1NEA4-1", "Q3ZKN0-1", "Q2KHW5-1", "F1MQP2-1" ], "evidence": [ { "id": "15421", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15421" } ] }, { "id": "R-BTA-434382", "name": "ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial outer membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-164991" ], "enzyme_list": [ "F1MEX9-1", "A0A3Q1LZ55-1" ], "evidence": [ { "id": "R-BTA-434382", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-434382" } ] }, { "id": "R-BTA-548843", "name": "ACSL3,4 ligate CoA to AA to form AA-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-29768" ], "output_participant_list": [], "enzyme_list": [ "F1MEX9-1", "A0A3Q1LZ55-1" ], "evidence": [ { "id": "R-BTA-548843", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-548843" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-164991", "participant_name": "LCFA-CoA [cytosol]", "crossref": [ { "id": "83139", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-29768", "participant_name": "AA [cytosol]", "crossref": [ { "id": "32395", "database": "ChEBI", "url": "" }, { "id": "ZINC000004474696", "database": "ZINC", "url": "" }, { "id": "C00219", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LVU8", "gene_name": "ACSL1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A0A3Q1LVU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVU8" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A0A3Q1LVU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVU8" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "A0A3Q1LVU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVU8" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "A0A3Q1LVU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVU8" } ] } ] }, { "uniprot_ac": "A0A3Q1LZ55", "gene_name": "ACSL4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A0A3Q1LZ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "A0A3Q1LZ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ55" } ] } ] }, { "uniprot_ac": "A0A3Q1NEA4", "gene_name": "ACSL6", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A0A3Q1NEA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEA4" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A0A3Q1NEA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEA4" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "A0A3Q1NEA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEA4" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "A0A3Q1NEA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEA4" } ] } ] }, { "uniprot_ac": "E1BCN4", "gene_name": "ACSBG2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "E1BCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN4" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "E1BCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN4" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "E1BCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN4" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "E1BCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN4" } ] } ] }, { "uniprot_ac": "F1MEX9", "gene_name": "ACSL3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MEX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX9" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "F1MEX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX9" } ] } ] }, { "uniprot_ac": "F1MQP2", "gene_name": "SLC27A2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MQP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQP2" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "F1MQP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQP2" } ] } ] }, { "uniprot_ac": "Q2KHW5", "gene_name": "ACSBG1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q2KHW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHW5" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q2KHW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHW5" } ] } ] }, { "uniprot_ac": "Q3ZKN0", "gene_name": "SLC27A1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q3ZKN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZKN0" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q3ZKN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZKN0" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2B9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2B9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2B9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2B9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4I1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4I1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD55", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD55-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP55", "url": "https://www.uniprot.org/uniprotkb/E1BP55", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP55-1", "url": "https://www.uniprot.org/uniprotkb/E1BP55-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVLGVASKLRQPAVGSKPVHTALLIPSLGTTGPQRSSSRPLELTELESSMLSCQLTFKSNCESEEKKPLQGKAKETEDSKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQIIANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLSRYKQQQHHQQQYYQSLVELQQRVTHASPQAEASQAKTQQDMQSSLAARYATQSNHSGIATSQKKPTRLPGPSRVPAAGNSSKVQGASNLNRRSQSFNSIDKNKPPNYANGNEKDSSKGPQPSSGVNGNMQPPGTAGQPPASAIPSPSTSKPWRSKSMNAKHSATSTMLTVKQGSPTTSPTPSADRLKPPASEGVKTAPSGQKSMLEKFKLVNARTALRPPQSASSGPSDGVKEDDAFSESGEMEGLNSGLNSGGSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQPKEKEEKNRDKSKVCTEKLVKDEKDQMMETAPKKTSKIASLIPKGSKTTAAKKESLIPSSSGIPKPGSKVPTAKQTVSPGNSASKESEKFRTTKGSPSQSFPKPITTEKASTSSCPAPLEGRETSHASLAGSSVGLVVQGSGQSMGNGAVQLPQQQQHSHPNTATVAPFIYRAHPENEGTSLPSADSCTSPTKMDLSYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDSTVTTEVNGRTIPNLTGRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTGRFIHTDPSRFMYTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSAEVDVGGYMSDGDILGKSLRTDDINSGYMTDGGLNLYTRSLHRAPDTTASRDVIQRGLHDVAVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNITVPSRKNTQLKTDSEKRSATDEPWESTEELKKPEEDFDSHGDGGGKWKGVSSGLPEDPEKTGQKASLAVSQTGSWRRGMSAQGGAPSRQKTGTSALKTPGKTDDAKASEKGKSPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATGSFGFKKPSGVGSSAMITSSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVGLHVSTKTSLQYRSLPRPSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASACGTQGLRQPGSKYPDIASPTFRRLFGAKAGGKPASAPNTEGVKSSSVMSSPSTTLARQGSLESPSSGTGSLGSAGGLSGSSSPLFNKPSDLTADVISLSHSLASSPASVHSFTSGGLVWAANLSSSSAGSKDTPSYQSMTSLHTSSESIDLPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQLDRNTLPKKGLRYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSATGKYHFSNLVSPTNLSQFNLPGPSMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKKNWVNSRGSELRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNGGDCGSASMKPSQSASASPLVWPPKKRQNGPVIYKHRSRICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNVGKPARPPSESASSTSSSSSRQSLGLSLNNLNIAESVTSDILLDDPGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSASLGLSSDCIASYCIGDVTRSHGPEVPELLPCGYLVGDNNVITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLAHKLAEYVTTKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGAELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEMEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRAPWEDPSKWVLDTYPWSSASLPQEGPALLQLRPEDVGYEGCISTKEATTSKHIPQADTEGDPLMNMLMKLQEAANYSGTQSCDSDSTSHHEDILDSSLESTL", "length": 2385, "header": "tr|E1BP55-1|E1BP55_BOVIN Isoform 1 of Neuron navigator 3 OS=Bos taurus OX=9913 GN=NAV3 PE=3 SV=4 CANONICAL=E1BP55-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LIL5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIL5/entry", "sequence": { "sequence": "MDLSSEMSRHGKNPVSHKLEDQKKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQIIANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLSRYKQQQHHQQQYYQSLVELQQRVTHASPQAEASQAKTQQDMQSSLAARYATQSNHSGIATSQKKPTRLPGPSRVPAAGNSSKVQGASNLNRRSQSFNSIDKNKPPNYANGNEKDSSKGPQPSSGVNGNMQPPGTAGQPPASAIPSPSTSKPWRSKSMNAKHSATSTMLTVKQGSPTTSPTPSADRLKPPASEGVKTAPSGQKSMLEKFKLVNARTALRPPQSASSGPSDGVKEDDAFSESGEMEGLNSGLNSGGSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQPKEKEEKNRDKSKVCTEKLVKDEKDQMMETAPKKTSKIASLIPKGSKTTAAKKESLIPSSSGIPKPGSKVPTAKQTVSPGNSASKESEKFRTTKGSPSQSFPKPITTEKASTSSCPAPLEGRETSHASLAGSSVGLVVQGSGQSMGNGAVQLPQQQQHSHPNTATVAPFIYRAHPENEGTSLPSADSCTSPTKMDLSYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDSTVTTEVNGRTIPNLTGRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTGRFIHTDPSRFMYTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSAEVDVGGYMSDGDILGKSLRTDDINSGYMTDGGLNLYTRSLHRAPDTTASRDVIQRGLHDVAVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNITVPSRKNTQLKTDSEKRSATDEPWESTEELKKPEEDFDSHGDGGGKWKGVSSGLPEDPEKTGQKASLAVSQTGSWRRGMSAQGGAPSRQKTGTSALKTPGKTDDAKASEKGKSPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATGSFGFKKPSGVGSSAMITSSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVGLHVSTKTSLQYRSLPRPSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASACGTQGLRQPGSKYPDIASPTFRRLFGAKAGGKPASAPNTEGVKSSSVMSSPSTTLARQGSLESPSSGTGSLGSAGGLSGSSSPLFNKPSDLTADVISLSHSLASSPASVHSFTSGGLVWAANLSSSSAGSKDTPSYQSMTSLHTSSESIDLPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSERYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSATGKYHFSNLVSPTNLSQFNLPGPSMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKKNWLRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNGGDCGSASMKPSQSASAICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNVGKPARPPSESASSTSSSSSRQSLGLSLNNLNIAESVTSDILLDDPGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSASLGLSSDCIASYCIGDVTRSHGPEVPELLPCGYLVGDNNVITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLAHKLAEYVTTKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGAELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEMEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRAPWEDPSKWVLDTYPWSSASLPQEGPALLQLRPEDVGYEGCISTKEATTSKHIPQADTEGDPLMNMLMKLQEAANYSGTQSCDSDSTSHHEDILDSSLESTL", "length": 2285, "header": "tr|A0A3Q1LIL5-1|E1BP55_BOVIN Computationally mapped isoform of Neuron navigator 3 OS=Bos taurus OX=9913 GN=NAV3 PE=3 SV=2 CANONICAL=E1BP55-1" }, "locus": { "chromosome": "5", "start_pos": 7681223, "end_pos": 7067516, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081239.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081239.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058923.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058923.2" } ] } }, { "isoform_ac": "A0A3Q1LVS5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVS5/entry", "sequence": { "sequence": "MDLSSEMSRHGKNPVSHKLEDQKKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQIIANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLSRYKQQQHHQQQYYQSLVELQQRVTHASPQAEASQAKTQQDMQSRLPGPSRVPAAGNSSKVQGASNLNRRSQSFNSIDKNKPPNYANGNEKDSSKGPQPSSGVNGNMQPPGTAGQPPASAIPSPSTSKPWRSKSMNAKHSATSTMLTVKQGSPTTSPTPSADRLKPPASEGVKTAPSGQKSMLEKFKLVNARTALRPPQSASSGPSDGVKEDDAFSESGEMEGLNSGLNSGGSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQPKEKEEKNRDKSKVCTEKLVKDEKDQMMETAPKKTSKIASLIPKGSKTTAAKKESLIPSSSGIPKPGSKVPTAKQTVSPGNSASKESEKFRTTKGSPSQSFPKPITTEKASTSSCPAPLEGRETSHASLAGSSVGLVVQGSGQSMGNGAVQLPQQQQHSHPNTATVAPFIYRAHPENEGTSLPSADSCTSPTKMDLSYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDSTVTTEVNGRTIPNLTGRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTGRFIHTDPSRFMYTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSAEVDVGGYMSDGDILGKSLRTDDINSGYMTDGGLNLYTRSLHRAPDTTASRDVIQRGLHDVAVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNITVPSRKNTQLKTDSEKRSATDEPWESTEELKKPEEDFDSHGDGGGKWKGVSSGLPEDPEKTGQKASLAVSQTGSWRRGMSAQGGAPSRQKTGTSALKTPGKTDDAKASEKGKSPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATGSFGFKKPSGVGSSAMITSSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVGLHVSTKTSLQYRSLPRPSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASACGTQGLRQPGSKYPDIASPTFRRLFGAKAGGKPASAPNTEGVKSSSVMSSPSTTLARQGSLESPSSGTGSLGSAGGLSGSSSPLFNKPSDLTADVISLSHSLASSPASVHSFTSGGLVWAANLSSSSAGSKDTPSYQSMTSLHTSSESIDLPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSERYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSATGKYHFSNLVSPTNLSQFNLPGPSMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKKNWLRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNGGDCGSASMKPSQSASAICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNVGKPARPPSESASSTSSSSSRQSLGLSLNNLNIAESVTSDILLDDPGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSASLGLSSDCIASYCIGDVTRSHGPEVPELLPCGYLVGDNNVITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLAHKLAEYVTTKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGAELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEMEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRAPWEDPSKWVLDTYPWSSASLPQEGPALLQLRPEDVGYEGCISTKEATTSKHIPQADTEGDPLMNMLMKLQEAANYSGTQSCDSDSTSHHEDILDSSLESTL", "length": 2262, "header": "tr|A0A3Q1LVS5-1|E1BP55_BOVIN Computationally mapped isoform of Neuron navigator 3 OS=Bos taurus OX=9913 GN=NAV3 PE=3 SV=2 CANONICAL=E1BP55-1" }, "locus": { "chromosome": "5", "start_pos": 7681223, "end_pos": 7067516, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076048.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076048.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061277.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061277.2" } ] } }, { "isoform_ac": "A0A3Q1LWH9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWH9/entry", "sequence": { "sequence": "MEFSFLSWCENGASADAVSWAVFTDSLEIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQIIANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLSRYKQQQHHQQQYYQSLVELQQRVTHASPQAEASQAKTQQDMQSSLAARYATQSNHSGIATSQKKPTRLPGPSRVPAAGNSSKVQGASNLNRRSQSFNSIDKNKPPNYANGNEKDSSKGPQPSSGVNGNMQPPGTAGQPPASAIPSPSTSKPWRSKSMNAKHSATSTMLTVKQGSPTTSPTPSADRLKPPASEGVKTAPSGQKSMLEKFKLVNARTALRPPQSASSGPSDGVKEDDAFSESGEMEGLNSGLNSGGSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQPKEKEEKNRDKSKVCTEKLVKDEKDQMMETAPKKTSKIASLIPKGSKTTAAKKESLIPSSSGIPKPGSKVPTAKQTVSPGNSASKESEKFRTTKGSPSQSFPKPITTEKASTSSCPAPLEGRETSHASLAGSSVGLVVQGSGQSMGNGAVQLPQQQQHSHPNTATVAPFIYRAHPENEGTSLPSADSCTSPTKMDLSYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDSTVTTEVNGRTIPNLTGRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTGRFIHTDPSRFMYTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSAEVDVGGYMSDGDILGKSLRTDDINSGYMTDGGLNLYTRSLHRAPDTTASRDVIQRGLHDVAVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNITVPSRKNTQLKTDSEKRSATDEPWESTEELKKPEEDFDSHGDGGGKWKGVSSGLPEDPEKTGQKASLAVSQTGSWRRGMSAQGGAPSRQKTGTSALKTPGKTDDAKASEKGKSPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATGSFGFKKPSGVGSSAMITSSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVGLHVSTKTSLQYRSLPRPSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASACGTQGLRQPGSKYPDIASPTFRRLFGAKAGGKPASAPNTEGVKSSSVMSSPSTTLARQGSLESPSSGTGSLGSAGGLSGSSSPLFNKPSDLTADVISLSHSLASSPASVHSFTSGGLVWAANLSSSSAGSKDTPSYQSMTSLHTSSESIDLPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQLDRNTLPKKGLRYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSATGKYHFSNLVSPTNLSQFNLPGPSMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKKNWLRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNGGDCGSASMKPSQSASAICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNVGKPARPPSESASSTSSSSSRQSLGLSLNNLNIAESVTSDILLDDPGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSASLGLSSDCIASYCIGDVTRSHGPEVPELLPCGYLVGDNNVITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLAHKLAEYVTTKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGAELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEMEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRAPWEDPSKWVLDTYPWSSASLPQEGPALLQLRPEDVGYEGCISTKEATTSKHIPQADTEGDPLMNMLMKLQEAANYSGTQSCDSDSTSHHEDILDSSLESTL", "length": 2303, "header": "tr|A0A3Q1LWH9-1|E1BP55_BOVIN Computationally mapped isoform of Neuron navigator 3 OS=Bos taurus OX=9913 GN=NAV3 PE=3 SV=2 CANONICAL=E1BP55-1" }, "locus": { "chromosome": "5", "start_pos": 7681223, "end_pos": 7207698, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087197.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087197.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059786.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059786.2" } ] } }, { "isoform_ac": "A0A3Q1M886-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M886/entry", "sequence": { "sequence": "MLSCQLTFKSNCESEEKKPLQGKAKETEDSKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQIIANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLSAEDSSKGPQPSSGVNGNMQPPGTAGQPPASAIPSPSTSKPWRSKSMNAKHSATSTMLTVKQGSPTTSPTPSADRLKPPASEGVKTAPSGQKSMLEKFKLVNARTALRPPQSASSGPSDGVKEDDAFSESGEMEGLNSGLNSGGSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQPKEKEEKNRDKSKVCTEKLVKDEKDQMMETAPKKTSKIASLIPKGSKTTAAKKESLIPSSSGIPKPGSKVPTAKQTVSPGNSASKESEKFRTTKGSPSQSFPKPITTEKASTSSCPAPLEGRETSHASLAGSSVGLVVQGSGQSMGNGAVQLPQQQQHSHPNTATVAPFIYRAHPENEGTSLPSADSCTSPTKMDLSYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDSTVTTEVNGRTIPNLTGRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTGRFIHTDPSRFMYTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSAEVDVGGYMSDGDILGKSLRTDDINSGYMTDGGLNLYTRSLHRAPDTTASRDVIQRGLHDVAVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNITVPSRKNTQLKTDSEKRSATDEPWESTEELKKPEEDFDSHGDGGGKWKGVSSGLPEDPEKTGQKASLAVSQTGSWRRGMSAQGGAPSRQKTGTSALKTPGKTDDAKASEKGKSPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATGSFGFKKPSGVGSSAMITSSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVGLHVSTKTSLQYRSLPRPSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASACGTQGLRQPGSKYPDIASPTFRRLFGAKAGGKPASAPNTEGVKSSSVMSSPSTTLARQGSLESPSSGTGSLGSAGGLSGSSSPLFNKPSDLTADVISLSHSLASSPASVHSFTSGGLVWAANLSSSSAGSKDTPSYQSMTSLHTSSESIDLPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQLDRNTLPKKGLRYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSATGKYHFSNLVSPTNLSQFNLPGPSMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKKNWLRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNGGDCGSASMKPSQSASAICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNVGKPARPPSESASSTSSSSSRQSLGLSLNNLNIAESVTSDILLDDPGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSASLGLSSDCIASYCIGDVTRSHGPEVPELLPCGYLVGDNNVITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLAHKLAEYVTTKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGAELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEMEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRAPWEDPSKWVLDTYPWSSASLPQEGPALLQLRPEDVGYEGCISTKEATTSKHIPQADTEGDPLMNMLMKLQEAANYSGTQSCDSDSTSHHEDILDSSLESTL", "length": 2175, "header": "tr|A0A3Q1M886-1|E1BP55_BOVIN Computationally mapped isoform of Neuron navigator 3 OS=Bos taurus OX=9913 GN=NAV3 PE=3 SV=2 CANONICAL=E1BP55-1" }, "locus": { "chromosome": "5", "start_pos": 7681223, "end_pos": 7301567, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069430.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069430.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064630.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064630.2" } ] } }, { "isoform_ac": "A0AAA9S2B9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2B9/entry", "sequence": { "sequence": "MIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLSRYKQQQHHQQQYYQSLVELQQRVTHASPQAEASQAKTQQDMQSSLAARYATQSNHSGIATSQKKPTRLPGPSRVPAAGNSSKVQGASNLNRRSQSFNSIDKNKPPNYANGNEKDSSKGPQPSSGVNGNMQPPGTAGQPPASAIPSPSTSKPWRSKSMNAKHSATSTMLTVKQGSPTTSPTPSADRLKPPASEGVKTAPSGQKSMLEKFKLVNARTALRPPQSASSGPSDGVKEDDAFSESGEMEGLNSGLNSGGSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQPKEKEEKNRDKSKVCTEKLVKDEKDQMMETAPKKTSKIASLIPKGSKTTAAKKESLIPSSSGIPKPGSKVPTAKQTVSPGNSASKESEKFRTTKGSPSQSFPKPITTEKASTSSCPAPLEGRETSHASLAGSSVGLVVQGSGQSMGNGAVQLPQQQQHSHPNTATVAPFIYRAHPENEGTSLPSADSCTSPTKMDLSYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDSTVTTEVNGRTIPNLTGRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTGRFIHTDPSRFMYTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSAEVDVGGYMSDGDILGKSLRTDDINSGYMTDGGLNLYTRSLHRAPDTTASRDVIQRGLHDVAVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNITVPSRKNTQLKTDSEKRSATDEPWESTEELKKPEEDFDSHGDGGGSWRRGMSAQGGAPSRQKTGTSALKTPGKTDDAKASEKGKSPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATGSFGFKKPSGVGSSAMITSSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVGLHVSTKTSLQYRSLPRPSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASACGTQGLRQPGSKYPDIASPTFRRLFGAKAGGKPASAPNTEGVKSSSVMSSPSTTLARQGSLESPSSGTGSLGSAGGLSGSSSPLFNKPSDLTADVISLSHSLASSPASVHSFTSGGLVWAANLSSSSAGSKDTPSYQSMTSLHTSSESIDLPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSERYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSATGKYHFSNLVSPTNLSQFNLPGPSMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKKNWLRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNGGDCGSASMKPSQSASAICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNVGKPARPPSESASSTSSSSSRQSLGLSLNNLNIAESVTSDILLDDPGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSASLGLSSDCIASYCIGDVTRSHGPEVPELLPCGYLVGDNNVITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLAHKLAEYVTTKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGAELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEMEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRAPWEDPSKWVLDTYPWSSASLPQEGPALLQLRPEDVGYEGCISTKEATTSKHIPQADTEGDPLMNMLMKLQEAANYSGTQSCDSDSTSHHEDILDSSLESTL", "length": 2177, "header": "tr|A0AAA9S2B9-1|E1BP55_BOVIN Computationally mapped isoform of Neuron navigator 3 OS=Bos taurus OX=9913 GN=NAV3 PE=3 SV=2 CANONICAL=E1BP55-1" }, "locus": { "chromosome": "5", "start_pos": 7681223, "end_pos": 7409987, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119477.2", "url": "https://www.ensembl.org/id/ENSBTAT00000119477.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077844.2", "url": "https://www.ensembl.org/id/ENSBTAP00000077844.2" } ] } }, { "isoform_ac": "A0AAA9T4I1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4I1/entry", "sequence": { "sequence": "MQRPAELSVFRSKEVRPKRACLQKQKSLTSLSLTSEGERRPAVRISNWFGNAAKASQRESSYAERRSLSRCSSRSVQSLYHTSLPGAWSLLPTSRSGSENLEEWTSRRGLEGESDEDSWSEDENVSSRPGSLSRSWAEEEGESCLREGTAHLDEDVILTMLGDLEEALYTDLLGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDSTVTTEVNGRTIPNLTGRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTGRFIHTDPSRFMYTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSAEVDVGGYMSDGDILGKSLRTDDINSGYMTDGGLNLYTRSLHRAPDTTASRDVIQRGLHDVAVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNITVPSRKNTQLKTDSEKRSATDEPWESTEELKKPEEDFDSHGDGGGKWKGVSSGLPEDPEKTGQKASLAVSQTGSWRRGMSAQGGAPSRQKTGTSALKTPGKTDDAKASEKGKSPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATGSFGFKKPSGVGSSAMITSSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVGLHVSTKTSLQYRSLPRPSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASACGTQGLRQPGSKYPDIASPTFRRLFGAKAGGKPASAPNTEGVKSSSVMSSPSTTLARQGSLESPSSGTGSLGSAGGLSGSSSPLFNKPSDLTADVISLSHSLASSPASVHSFTSGGLVWAANLSSSSAGSKDTPSYQSMTSLHTSSESIDLPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSERYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSATGKYHFSNLVSPTNLSQFNLPGPSMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKKNWLRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNGGDCGSASMKPSQSASAICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNVGKPARPPSESASSTSSSSSRQSLGLSLNNLNIAESVTSDILLDDPGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSASLGLSSDCIASYCIGDVTRSHGPEVPELLPCGYLVGDNNVITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLAHKLAEYVTTKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGAELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEMEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRAPWEDPSKWVLDTYPWSSASLPQEGPALLQLRPEDVGYEGCISTKEATTSKHIPQADTEGDPLMNMLMKLQEAANYSGTQSCDSDSTSHHEDILDSSLESTL", "length": 1841, "header": "tr|A0AAA9T4I1-1|E1BP55_BOVIN Computationally mapped isoform of Neuron navigator 3 OS=Bos taurus OX=9913 GN=NAV3 PE=3 SV=1 CANONICAL=E1BP55-1" }, "locus": { "chromosome": "5", "start_pos": 7681223, "end_pos": 7503985, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088259.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088259.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090641.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090641.1" } ] } }, { "isoform_ac": "A0AAA9TD55-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD55/entry", "sequence": { "sequence": "MDLSSEMSRHGKNPVSHKLEDQKKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQIIANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLSRYKQQQHHQQQYYQSLVELQQRVTHASPQAEASQAKTQQDMQSSLAARYATQSNHSGIATSQKKPTRLPGPSRVPAAGNSSKVQGASNLNRRSQSFNSIDKNKPPNYANGNEKDSSKGPQPSSGVNGNMQPPGTAGQPPASAIPSPSTSKPWRSKSMNAKHSATSTMLTVKQGSPTTSPTPSADRLKPPASEGVKTAPSGQKSMLEKFKLVNARTALRPPQSASSGPSDGVKEDDAFSESGEMEGLNSGLNSGGSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQPKEKEEKNRDKSKVCTEKLVKDEKDQMMETAPKKTSKIASLIPKGSKTTAAKKESLIPSSSGIPKPGSKVPTAKQTVSPGNSASKESEKFRTTKGSPSQSFPKPITTEKASTSSCPAPLEGRETSHASLAGSSVGLVVQGSGQSMGNGAVQLPQQQQHSHPNTATVAPFIYRAHPENEGTSLPSADSCTSPTKMDLSYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDSTVTTEVNGRTIPNLTGRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTGRFIHTDPSRFMYTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSAEVDVGGYMSDGDILGKSLRTDDINSGYMTDGGLNLYTRSLHRAPDTTASRDVIQRGLHDVAVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNITVPSRKNTQLKTDSEKRSATDEPWESTEELKKPEEDFDSHGDGGGKWKGVSSGLPEDPEKTGQKASLAVSQTGSWRRGMSAQGGAPSRQKTGTSALKTPGKTDDAKASEKGKSPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATGSFGFKKPSGVGSSAMITSSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVGLHVSTKTSLQYRSLPRPSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASACGTQGLRQPGSKYPDIASPTFRRLFGAKAGGKPASAPNTEGVKSSSVMSSPSTTLARQGSLESPSSGTGSLGSAGGLSGSSSPLFNKPSDLTADVISLSHSLASSPASVHSFTSGGLVWAANLSSSSAGSKDTPSYQSMTSLHTSSESIDLPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQLDRNTLPKKGLRYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSATGKYHFSNLVSPTNLSQFNLPGPSMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKKNWLRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNGGDCGSASMKPSQSASAICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNVGKPARPPSESASSTSSSSSRQSLGLSLNNLNIAESVTSDILLDDPGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSASLGLSSDCIASYCIGDVTRSHGPEVPELLPCGYLVGDNNVITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLAHKLAEYVTTKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGAELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEMEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRAPWEDPSKWVLDTYPWSSASLPQEGPALLQLRPEDVGYEGCISTKEATTSKHIPQADTEGDPLPGVQQPQKLDGDSSLCPLQMLMVGFIRSPPLEVNA", "length": 2295, "header": "tr|A0AAA9TD55-1|E1BP55_BOVIN Computationally mapped isoform of Neuron navigator 3 OS=Bos taurus OX=9913 GN=NAV3 PE=3 SV=1 CANONICAL=E1BP55-1" }, "locus": { "chromosome": "5", "start_pos": 7680607, "end_pos": 7067516, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104268.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104268.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094078.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094078.1" } ] } }, { "isoform_ac": "E1BP55-1", "url": "https://www.uniprot.org/uniprotkb/E1BP55/entry", "sequence": { "sequence": "MPVLGVASKLRQPAVGSKPVHTALLIPSLGTTGPQRSSSRPLELTELESSMLSCQLTFKSNCESEEKKPLQGKAKETEDSKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQIIANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLSRYKQQQHHQQQYYQSLVELQQRVTHASPQAEASQAKTQQDMQSSLAARYATQSNHSGIATSQKKPTRLPGPSRVPAAGNSSKVQGASNLNRRSQSFNSIDKNKPPNYANGNEKDSSKGPQPSSGVNGNMQPPGTAGQPPASAIPSPSTSKPWRSKSMNAKHSATSTMLTVKQGSPTTSPTPSADRLKPPASEGVKTAPSGQKSMLEKFKLVNARTALRPPQSASSGPSDGVKEDDAFSESGEMEGLNSGLNSGGSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQPKEKEEKNRDKSKVCTEKLVKDEKDQMMETAPKKTSKIASLIPKGSKTTAAKKESLIPSSSGIPKPGSKVPTAKQTVSPGNSASKESEKFRTTKGSPSQSFPKPITTEKASTSSCPAPLEGRETSHASLAGSSVGLVVQGSGQSMGNGAVQLPQQQQHSHPNTATVAPFIYRAHPENEGTSLPSADSCTSPTKMDLSYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDSTVTTEVNGRTIPNLTGRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTGRFIHTDPSRFMYTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSAEVDVGGYMSDGDILGKSLRTDDINSGYMTDGGLNLYTRSLHRAPDTTASRDVIQRGLHDVAVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNITVPSRKNTQLKTDSEKRSATDEPWESTEELKKPEEDFDSHGDGGGKWKGVSSGLPEDPEKTGQKASLAVSQTGSWRRGMSAQGGAPSRQKTGTSALKTPGKTDDAKASEKGKSPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATGSFGFKKPSGVGSSAMITSSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVGLHVSTKTSLQYRSLPRPSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTSASACGTQGLRQPGSKYPDIASPTFRRLFGAKAGGKPASAPNTEGVKSSSVMSSPSTTLARQGSLESPSSGTGSLGSAGGLSGSSSPLFNKPSDLTADVISLSHSLASSPASVHSFTSGGLVWAANLSSSSAGSKDTPSYQSMTSLHTSSESIDLPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQLDRNTLPKKGLRYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSATGKYHFSNLVSPTNLSQFNLPGPSMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYSTAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKKNWVNSRGSELRSSFKQAFGKKKSTKPPSSHSDIEELTDSSLPASPKLPHNGGDCGSASMKPSQSASASPLVWPPKKRQNGPVIYKHRSRICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNVGKPARPPSESASSTSSSSSRQSLGLSLNNLNIAESVTSDILLDDPGDATGHKDGRSVKIIVSISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSASLGLSSDCIASYCIGDVTRSHGPEVPELLPCGYLVGDNNVITVNLKGVEENSLDSFVFDTLIPKPITQRYFNLLMEHHRIILSGPSGTGKTYLAHKLAEYVTTKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQCSADNNGAELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGVSSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEMEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKRAPWEDPSKWVLDTYPWSSASLPQEGPALLQLRPEDVGYEGCISTKEATTSKHIPQADTEGDPLMNMLMKLQEAANYSGTQSCDSDSTSHHEDILDSSLESTL", "length": 2385, "header": "tr|E1BP55-1|E1BP55_BOVIN Isoform 1 of Neuron navigator 3 OS=Bos taurus OX=9913 GN=NAV3 PE=3 SV=4 CANONICAL=E1BP55-1" }, "locus": { "chromosome": "5", "start_pos": 7681223, "end_pos": 7301417, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061560.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061560.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053437.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053437.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 360, "start_aa": "Thr", "end_pos": 360, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr360", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BP55", "url": "https://www.uniprot.org/uniprotkb/E1BP55" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "E1BP55", "url": "https://www.uniprot.org/uniprotkb/E1BP55" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "E1BP55", "url": 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"url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA34/entry", "sequence": { "sequence": "MEEEKYLPELMAERDSLDPSFVHASRLLAEEIEKFQGSDGKSEDEEEKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKAKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEDSGRGRGVRGRGIRIAPTAPSRGRGGAIPPPPPPGRGILTPRGTTVTRGALPVPPIARGVPTPRARGSPTMPGYRAPPLPAHKGYEAYGYDGYGGEYDDEIYETYDNSYPIQAQRRASPGNCCALNQSSRVNTVNRLNKAQT", "length": 324, "header": "tr|A0A3Q1MA34-1|E1BP48_BOVIN Computationally mapped isoform of KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Bos taurus OX=9913 GN=KHDRBS2 PE=3 SV=2 CANONICAL=E1BP48-1" }, "locus": { "chromosome": "23", "start_pos": 961012, "end_pos": 333055, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082314.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082314.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065370.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065370.2" } ] } }, { "isoform_ac": "A0A3Q1NM39-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NM39/entry", "sequence": { "sequence": "MEEEKYLPELMAERDSLDPSFVHASRLLAEEIEKFQGSDGKSEDEEEKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKAKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEDSGRGRGVRGRGIRIAPTAPSRGRGGAIPPPPPPGRGILTPRGTTVTRGALPVPPIARGVPTPRARGSPTMPGYRAPPLPAHKGYEAYGYDGYGGEYDDEIYETYDNSYPIQAQSVPEYYDYGHGVSEDAYDSYGNHKQRAHS", "length": 325, "header": "tr|A0A3Q1NM39-1|E1BP48_BOVIN Computationally mapped isoform of KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Bos taurus OX=9913 GN=KHDRBS2 PE=3 SV=2 CANONICAL=E1BP48-1" }, "locus": { "chromosome": "23", "start_pos": 961012, "end_pos": 268765, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082740.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082740.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073597.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073597.2" } ] } }, { "isoform_ac": "A0AAA9SV08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV08/entry", "sequence": { "sequence": "MEEEKYLPELMAERDSLDPSFVHASRLLAEEIEKFQGSDGKSEDEEEKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKAKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEDSGRGRGVRGRGIRIAPTAPSRGRGGAIPPPPPPGRGILTPRGTTVTRGALPVPPIARGVPTPRARGSPTMPGYRAPPLPAHKGYEAYGYDGYGGEYDDEIYETYDNSYPIQAQSVPEYYDYGHGVSEDAYDSYAPEEWATTHSSLKAPPSSAKYHLP", "length": 340, "header": "tr|A0AAA9SV08-1|E1BP48_BOVIN Computationally mapped isoform of KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Bos taurus OX=9913 GN=KHDRBS2 PE=3 SV=1 CANONICAL=E1BP48-1" }, "locus": { "chromosome": "23", "start_pos": 961012, "end_pos": 269454, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105964.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105964.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088013.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088013.1" } ] } }, { "isoform_ac": "E1BP48-1", "url": "https://www.uniprot.org/uniprotkb/E1BP48/entry", "sequence": { "sequence": "MEEEKYLPELMAERDSLDPSFVHASRLLAEEIEKFQGSDGKSEDEEEKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKAKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEDSGRGRGVRGRGIRIAPTAPSRGRGGAIPPPPPPGRGILTPRGTTVTRGALPVPPIARGVPTPRARGSPTMPGYRAPPLPAHKGYEAYGYDGYGGEYDDEIYETYDNSYPIQAQSVPEYYDYGHGVSEDAYDSYGHYSLPYTPEEWATTHSSLKAPPSRSARGGYREHPYGRY", "length": 355, "header": "tr|E1BP48-1|E1BP48_BOVIN Isoform 1 of KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Bos taurus OX=9913 GN=KHDRBS2 PE=3 SV=3 CANONICAL=E1BP48-1" }, "locus": { "chromosome": "23", "start_pos": 961012, "end_pos": 270841, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061105.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061105.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053440.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053440.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 200, "start_aa": "Thr", "end_pos": 200, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr200", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:789972", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789972", "resource": "KEGG Pathway" }, { "id": "R-BTA-8849468", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8849468", "resource": "Reactome", "description": "PTK6 Regulates Proteins Involved in RNA Processing" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BP48", "url": "https://www.uniprot.org/uniprotkb/E1BP48" } ], "pmid": "" }, { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "E1BP48", "url": "https://www.uniprot.org/uniprotkb/E1BP48" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "E1BP48", "url": "https://www.uniprot.org/uniprotkb/E1BP48" } ], "pmid": "" }, { "name": "poly(A) binding", "id": "GO:0008143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008143", "evidence": [ { "database": "UniProtKB", "id": "E1BP48", "url": "https://www.uniprot.org/uniprotkb/E1BP48" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BP48", "url": "https://www.uniprot.org/uniprotkb/E1BP48" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BP48", "url": "https://www.uniprot.org/uniprotkb/E1BP48" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "E1BP48", "url": "https://www.uniprot.org/uniprotkb/E1BP48" } ], "pmid": "" }, { "name": "regulation of alternative mRNA splicing, via spliceosome", "id": "GO:0000381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000381", "evidence": [ { "database": "UniProtKB", "id": "E1BP48", "url": "https://www.uniprot.org/uniprotkb/E1BP48" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BP48-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 355, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BP48-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BP48" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BP48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP48" }, { "id": "SM00322", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00322" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "K Homology", "eco_id": "ECO_0000259", "start_pos": 58, "end_pos": 156, "start_aa": "Ile", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 200 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 179, "end_pos": 181 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M4Q2-1", "uniprot_ac": "A0A3Q1M4Q2", "uniprot_id": "A0A3Q1M4Q2_BOVIN", "mass": { "chemical_mass": 99755.0, "monoisotopic_mass": 99755.0 }, "refseq": { "ac": "NP_001178147", "name": "stonin-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178147" }, "gene_names": [ { "name": "STON2", "type": "recommended", "evidence": [ { "id": "A0A3Q1M4Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2" } ] }, { "name": "STON2", "type": "synonym", "evidence": [ { "id": "NP_001178147", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178147" } ] } ], "protein_names": [ { "name": "Stonin-2", "type": "recommended", "evidence": [ { "id": "A0A3Q1M4Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2/entry#names_and_taxonomy" } ] }, { "name": "stonin-2", "type": "synonym", "evidence": [ { "id": "NP_001178147", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178147" } ] } ], "function": [ { "annotation": "Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2#function" }, { "database": "UniProtKB", "id": "PIRNR037099", "url": "https://www.uniprot.org/uniprotkb/PIRNR037099#function" }, { "database": "UniProtKB", "id": "ARBA00055858", "url": "https://www.uniprot.org/uniprotkb/ARBA00055858#function" }, { "database": "UniProtKB", "id": "E1BNH3", "url": "https://www.uniprot.org/uniprotkb/E1BNH3#function" }, { "database": "UniProtKB", "id": "A0A3Q1MWJ5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWJ5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "STON2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2", "locus": { "chromosome": "10", "start_pos": 92547277, "end_pos": 92725615, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025308", "url": "https://www.ensembl.org/id/ENSBTAG00000025308" } ] } } ], "crossref": [ { "id": "A0A3Q1M4Q2", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M4Q2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025308", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025308", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09263", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09263", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "785664", "url": "https://www.ncbi.nlm.nih.gov/gene/785664", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028565", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028565", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050431", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050431", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785664", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785664", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EWVSFND", "url": "https://omabrowser.org/oma/group/EWVSFND/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10529", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10529", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00928", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00928", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12016", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12016", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001178147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178147", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWJ5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNH3", "url": "https://www.uniprot.org/uniprotkb/E1BNH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNH3-1", "url": "https://www.uniprot.org/uniprotkb/E1BNH3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTLDHVIATHQSEWVSFNEEPLFPVPSEGGPKEHLPGASSSSDQSESSSGEHHALDGGSQDLSHSEHDDSSEKLGLISEAASPPGSPEQRPPELVSAISSWVQFEDDAPWASSSPPPKEAGGTATSLAMPCWTCPSFDSLGRCPLPSESSWTTHSEDTSSPSFGPSYTDLQLVSAGEQSGLASGADSTDNSSSLQEDEEVEMEAISWQAGSPAMNGHPTTPVTSARFPSWVTFDDNEVSGPLSPITSPLKPETLPLASVTPDGPYNLTGSFKKRERPKSSLMNFSKVQKLDVSSVSHPPAVPEAPPWRATNPFLNETLQDVQPSPINPFRAFFEEQERRAQSSSVSSTLGKSQRDSLIVVYRDAISFDDSSRNQSRSDAVEKLKRLQIEDSDHLGGVTLPDDDPAAWAELDAHPAGSEQSPPRDGWPMMLRIPEKKNIMSSRHWGPIYVKLTDGGYLQLYYEQGLERPFREFKLEMYHEISEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHLAEREQVIKLGTTNYEDFLSFIRAVQDRLMELPVLSTELSTVGLNYLEEEMTVDVQDEFSGLVSKGDNQILQHRVLTRIHVLSFLSGLAECRLGLNDVLVKGNEVVSRQDIVPTTTTKWIRLHECRFHGCVDEDVFRGSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTAASIHGAEVEVQSWLRMSAGFSSNWDPLTQVPCENVMVRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSASISGSEPVMRVTLGTAKYEHAFNAIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKAAVRSISVEDKTDVRKWVNYSAHYSYKVEIEQKKSLKLDLEGDDMENPKECGVQ", "length": 897, "header": "tr|A0A3Q1M4Q2-1|A0A3Q1M4Q2_BOVIN Isoform 1 of Stonin-2 OS=Bos taurus OX=9913 GN=STON2 PE=3 SV=1 CANONICAL=A0A3Q1M4Q2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2/entry", "sequence": { "sequence": "MTTLDHVIATHQSEWVSFNEEPLFPVPSEGGPKEHLPGASSSSDQSESSSGEHHALDGGSQDLSHSEHDDSSEKLGLISEAASPPGSPEQRPPELVSAISSWVQFEDDAPWASSSPPPKEAGGTATSLAMPCWTCPSFDSLGRCPLPSESSWTTHSEDTSSPSFGPSYTDLQLVSAGEQSGLASGADSTDNSSSLQEDEEVEMEAISWQAGSPAMNGHPTTPVTSARFPSWVTFDDNEVSGPLSPITSPLKPETLPLASVTPDGPYNLTGSFKKRERPKSSLMNFSKVQKLDVSSVSHPPAVPEAPPWRATNPFLNETLQDVQPSPINPFRAFFEEQERRAQSSSVSSTLGKSQRDSLIVVYRDAISFDDSSRNQSRSDAVEKLKRLQIEDSDHLGGVTLPDDDPAAWAELDAHPAGSEQSPPRDGWPMMLRIPEKKNIMSSRHWGPIYVKLTDGGYLQLYYEQGLERPFREFKLEMYHEISEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHLAEREQVIKLGTTNYEDFLSFIRAVQDRLMELPVLSTELSTVGLNYLEEEMTVDVQDEFSGLVSKGDNQILQHRVLTRIHVLSFLSGLAECRLGLNDVLVKGNEVVSRQDIVPTTTTKWIRLHECRFHGCVDEDVFRGSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTAASIHGAEVEVQSWLRMSAGFSSNWDPLTQVPCENVMVRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSASISGSEPVMRVTLGTAKYEHAFNAIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKAAVRSISVEDKTDVRKWVNYSAHYSYKVEIEQKKSLKLDLEGDDMENPKECGVQ", "length": 897, "header": "tr|A0A3Q1M4Q2-1|A0A3Q1M4Q2_BOVIN Isoform 1 of Stonin-2 OS=Bos taurus OX=9913 GN=STON2 PE=3 SV=1 CANONICAL=A0A3Q1M4Q2-1" }, "locus": { "chromosome": "10", "start_pos": 92676985, "end_pos": 92548281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083225.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083225.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065212.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065212.1" } ] } }, { "isoform_ac": "A0A3Q1MWJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWJ5/entry", "sequence": { "sequence": "MTTLDHVIATHQSEWVSFNEEPLFPVPSEGGPKEHLPGASSSSDQSESSSGEHHALDGGSQDLSHSEHDDSSEKLGLISEAASPPGSPEQRPPELVSAISSWVQFEDDAPWASSSPPPKEAGGTDNSSSLQEDEEVEMEAISWQAGSPAMNGHPTTPVTSARFPSWVTFDDNEVSGPLSPITSPLKPETLPLASVTPDGPYNLTGSFKKRERPKSSLMNFSKVQKLDVSSVSHPPAVPEAPPWRATNPFLNETLQDVQPSPINPFRAFFEEQERRAQSSSVSSTLGKSQRDSLIVVYRDAISFDDSSRNQSRSDAVEKLKRLQIEDSDHLGGVTLPDDDPAAWAELDAHPAGSEQSPPRDGWPMMLRIPEKKNIMSSRHWGPIYVKLTDGGYLQLYYEQGLERPFREFKLEMYHEISEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHLAEREQVIKLGTTNYEDFLSFIRAVQDRLMELPVLSTELSTVGLNYLEEEMTVDVQDEFSGLVSKGDNQILQHRVLTRIHVLSFLSGLAECRLGLNDVLVKGNEVVSRQDIVPTTTTKWIRLHECRFHGCVDEDVFRGSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTAASIHGAEVEVQSWLRMSAGFSSNWDPLTQVPCENVMVRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSASISGSEPVMRVTLGTAKYEHAFNAIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKAAVRSISVEDKTDVRKWVNYSAHYSYKVEIEQKKSLKLDLEGDDMENPKECGVQ", "length": 832, "header": "tr|A0A3Q1MWJ5-1|A0A3Q1M4Q2_BOVIN Computationally mapped isoform of Stonin-2 OS=Bos taurus OX=9913 GN=STON2 PE=3 SV=2 CANONICAL=A0A3Q1M4Q2-1" }, "locus": { "chromosome": "10", "start_pos": 92676985, "end_pos": 92548281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082605.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082605.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059863.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059863.2" } ] } }, { "isoform_ac": "E1BNH3-1", "url": "https://www.uniprot.org/uniprotkb/E1BNH3/entry", "sequence": { "sequence": "MTTLDHVIATHQSEWVSFNEEPLFPVPSEGGPKEHLPGASSSSDQSESSSGEHHALDGGSQDLSHSEHDDSSEKLGLISEAASPPGSPEQRPPELVSAISSWVQFEDDAPWASSSPPPKEAGGTGRPATSLAMPCWTCPSFDSLGRCPLPSESSWTTHSEDTSSPSFGPSYTDLQLVSAGEQSGLASGADSTDGRTEWQRGSRQEAGSPVPACMRHTSSRTHLDPSPPQHPTRSLSPSKGLQGASAPHDNSSSLQEDEEVEMEAISWQAGSPAMNGHPTTPVTSARFPSWVTFDDNEVSGPLSPITSPLKPETLPLASVTPDGPYNLTGSFKKRERPKSSLMNFSKVQKLDVSSVSHPPAVPEAPPWRATNPFLNETLQDVQPSPINPFRAFFEEQERRAQSSSVSSTLGKSQRDSLIVVYRDAISFDDSSRNQSRSDAVEKLKRLQIEDSDHLGGVTLPDDDPAAWAELDAHPAGSEQSPPRDGWPMMLRIPEKKNIMSSRHWGPIYVKLTDGGYLQLYYEQGLERPFREFKLEMYHEISEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHLAEREQVIKLGTTNYEDFLSFIRAVQDRLMELPVLSTELSTVGLNYLEEEMTVDVQDEFSGLVSKGDNQILQHRVLTRIHVLSFLSGLAECRLGLNDVLVKGNEVVSRQDIVPTTTTKWIRLHECRFHGCVDEDVFRGSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTAASIHGAEVEVQSWLRMSAGFSSNWDPLTQVPCENVMVRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSASISGSEPVMRVTLGTAKYEHAFNAIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKAAVRSISVEDKTDVRKWVNYSAHYSYKVEIEQKKSLKLDLEGDDMENPKECGVQ", "length": 956, "header": "tr|E1BNH3-1|E1BNH3_BOVIN Computationally mapped isoform of Stonin-2 OS=Bos taurus OX=9913 GN=STON2 PE=3 SV=4 CANONICAL=A0A3Q1M4Q2-1" }, "locus": { "chromosome": "10", "start_pos": 92676985, "end_pos": 92548281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061260.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061260.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053529.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053529.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:785664", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785664", "resource": "KEGG Pathway" }, { "id": "R-BTA-8856825", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "resource": "Reactome", "description": "Cargo recognition for clathrin-mediated endocytosis" }, { "id": "R-BTA-8856828", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856828", "resource": "Reactome", "description": "Clathrin-mediated endocytosis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1T0V4-1", "protein_name": "Stonin-2", "gene_name": "STON2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTTLDHVIATHQSEWVSFSEEPLFPAPSEGSTEEHLPGPSSSSDQSESSSGENQVGDGGSQDLSHSEHDDSSEKTGLISEAASPPGSPEQPSPDLASAISSWVQFEDDTPWASTSPPHKEAGGTATSLTLPCWTCPSFDSLGRCPLPSENSWTTHSEDTSSPSFGPSYTDLQLVSAEEQMSGPASGADSTDNSSSLHEDEEVEMEAISWQASSPAMNGHPATPVTSARFPSWVTFDDNEVSCPLPPVTSPLKPKTPSIASVIPDVPYNSTGSFKKRERPKSTLMNFSKVQKLDISSLNHPPSVPEAPPWRATNPFLNETLQDIQPSPINPFRAFFEEQERRSQSNSVSGATGKSQRDSLIIIYQDAISFDDSSKTQSHSDAVEKLKRLQIEDPDHLGRVTLPDDDPIAWLELGDHPPGSVLSQPRDGWPMMLRIPEKKNIMSSRHWGPIYIKLTDSGYLQLYYEQGLEKPFREFKLEICHEISEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHMAEREQVIKLGTTNYDDFLSFIRAVQDHLMDLPVLSMDLSTVGLNYLEEEITVDVRDEFSGLVSKGDNQILQHCVLTRIHILSFLSGLAECRLGLNDVLVKGNEIVSRQDIMPTTTTKWIKLHECRFHGCVDEDVFNSSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTVASINGAEVEVQSWLRMSTGFSSNCDPLTQVPCENVMVRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSTSVSGSEPVMRVTLGTAKYEHAFNSIVWRITRLPDKNSASGHPHCFFCHLELGSDREVPSRFANYVNVEFSMPTTSASKAAVRSISVEDKTDVRKWVNYSAHYSYKVEIEQKKSLKPDFEGDEVENPKECGVQ", "length": 898 }, "evidence": [ { "id": "A0A3Q1M4Q2", "url": "https://omabrowser.org/oma/group/A0A3Q1M4Q2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QMI2-1", "protein_name": "Stonin-2", "gene_name": "Ston2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTTLDHVIATHQSEWVSFSEEPLFPAPSEGVTEEHFPGSSSSSDPSESSSGENPAVDGGCQDLSHSEQDDSSEKMGLISEATTPPGSPMQATPDLASAISNWVQFEDDTPWSNTSPPHKETALTLTMPCWTCPSFDSLRRCPLTSESSWTTHSEDTSSPSVAPSYTDLQLINTEEQASGRASRTDSTTDNSSSLQEDEEVEMEAISWRAGSPAMNGHPTVPPVTTARFPSWVTFDDSEVSCPLPPPVTSPMKPSTPPVATAIPDVPYNSTGSFKRDRPKSTLMNFSKVQKLDISPLNRPPSVIEAPPWRATNPFLNETLQDVQPSPINPFSAFFEEQERRSQNSSVSSTTGKSQRDSLIVIYQDAISFEDSGKSQPQPDAAIEKLKQLQIDDPDRVGSTSLPDDDPIAWVELDAHSPASALSQPRDGWPMMLRIPEKKNIMSSRHWGPIYIKLTDSGYLQLYYEQGLEKPFREFKLEICHEVSEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHTAEREQVIKLGTTNYDDFLSFIHAVQDCLMDLPVLSMDLSTVGLNYLEEEITVDVRDEFSGTVSKGDNRILQHCVLTRIHILSFLSGLAECRLGLNDILIKGNEIVSRQDIMPTTTTKWVKLHECRFHGCVDEDVFNSSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTAASINGAEVEVQSWLRMSPGFSSNRDPLTQVPCENVMVRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSAGISGSEPVMRVTLGTAKYEHAFNAIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANYVNVEFSMPTTSASKAAVRSISVEDKPGVRKWVNYSAHYSYKVEIEQKKSLKPDFEGEELDNPKECGVQ", "length": 898 }, "evidence": [ { "id": "A0A3Q1M4Q2", "url": "https://omabrowser.org/oma/group/A0A3Q1M4Q2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4AB66-1", "protein_name": "Stonin-2", "gene_name": "Ston2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTTLDHVIATHQSEWVSFSEEPLFPTPLEGGTEEHFPGLSSSSDRSESSSGENHAVDEGSQDLSHSEQDDSSEKMGLISEAASPPGSPVQPTPDLASAISNWVQFEDDTPWSNTSAPHKETALTLTVPCWTCPSLDSLRRCPLASESSWTTHSEDTSSPSVAPSYTDLQLINAEEQASGRASGTDSTDNSSSLQEDEEVEMETISWWAGSPAMNGHPAVPQVTTARFPSWVTFEDNEVGCPSPTVPSPKKPNAPSAATAGPDVPFNSTGSFKRDRPKSTLMNLSKVQKLDISSLNRPPSVTEAPPWRATNPFLNESLQDIQPSPINPFSAFFEEQERRSQNSSISGTSGKSQRDSLIVIYQDAISFDDSGKSQSHPDAIEKLKQLQIDDPDPVGNAALPDDDPTASVEPDAPSPTSALSQPRDGWPMMLRIPEKKNIMSSRHWGPIYIKLTDSGYLQLYYEQGLEKPFREFKLEICHEVSEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHAAEREQVIKLGTTNYDDFLSFIHAVQDRLMDLPVQSMDLSTVGLNYLEEEITVDIRDEFSGTVSKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILIKGNEIVSRQDIMPTTTTKWIKLHECRFHGCVDEDVFNSSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTAASINGAEVEVQSWLRMSPGFSSNRDPLTQVPCENVMVRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSAGASGSEPVMRVTLGTAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKAAVRSISVEDKPDVRKWVNYSAHYSYKVEIEQKKSLKPDFEGEDLENPKECGVQ", "length": 895 }, "evidence": [ { "id": "A0A3Q1M4Q2", "url": "https://omabrowser.org/oma/group/A0A3Q1M4Q2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BZ60-1", "protein_name": "Stonin-2", "gene_name": "Ston2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTTLDHVIATHQSEWVSFSEEPLFPTPLEGGTEEHFPGLSSSSERSESSSGENHVVDEGSQDLSHSEQDDSSEKMGLISEAASPPGSPVQPTPDLASAISNWVQFEDDTPWSSTSPPHKETALTLTMPCWTCPSFDSLRRCPLTSESSWTTHSEDTSSPSVAPSYTDLQLINTEEQASGRASGTDSTDNSSSLQEDEEVEMEAISWWAGSPAMNGHPAAPPVTTARFPSWVTFEDNEVGCPSPPVPSPKKPNTPSAATAAPDVPFNSTGSFKRDRPKSTLMNLPKVQKLDISSLNRPPSVIEAPPWRATNPFLNETLQDVQPSPINPFSAFFEEQERRSQNSSVSSTTGKSQRDSLIVVYQDAISFDDSGKSQPHPDAIEKLKQLQIDDPDPVGNTALPDDDPTASVELDAPSPASALSQPRDGWPMMLRIPEKKNIMSSRHWGPIYIKLTASGYLQLYYEQGLEKPFREFKLEICHEVSEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHAAEREQVIKLGTTNYDDFRSFIHAVQDRLMDLPVLSMDLSTVGLNYLEEEITVDVRDEFSGTVGKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILIKGNEIVSRQDIMPTTTTKWIKLHECRFHGCVDEDVFNSSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTAASINGAEVEVQSWLRMSPGFSSNRDPLTQVPCENVMVRYPVPSEWVKNFRRDSVLGEKSLKAKVNRGASFGSAGASGSEPVMRVTLGTAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANYVNVEFSMPTTSASKAAVRSVSVEDKPDVRKWVNYSAHYSYKVEIEQKKSLKPDFEGEDLENPKECGVQ", "length": 895 }, "evidence": [ { "id": "A0A3Q1M4Q2", "url": "https://omabrowser.org/oma/group/A0A3Q1M4Q2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WXE9-1", "protein_name": "Stonin-2", "gene_name": "STON2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTTLDHVIATHQSEWVSFNEEPPFPAHSQGGTEEHLPGLSSSPDQSESSSGENHVVDGGSQDHSHSEQDDSSEKMGLISEAASPPGSPEQPPPDLASAISNWVQFEDDTPWASTSPPHQETAETALPLTMPCWTCPSFDSLGRCPLTSESSWTTHSEDTSSPSFGCSYTDLQLINAEEQTSGQASGADSTDNSSSLQEDEEVEMEAISWQASSPAMNGHPAPPVTSARFPSWVTFDDNEVSCPLPPVTSPLKPNTPPSASVIPDVPYNSMGSFKKRDRPKSTLMNFSKVQKLDISSLNRTPSVTEASPWRATNPFLNETLQDVQPSPINPFSAFFEEQERRSQNSSISSTTGKSQRDSLIVIYQDAISFDDSSKTQSHSDAVEKLKQLQIDDPDHFGSATLPDDDPVAWIELDAHPPGSARSQPRDGWPMMLRIPEKKNIMSSRHWGPIFVKLTDTGYLQLYYEQGLEKPFREFKLEICHEISEPRLQNYDENGRIHSLRIDRVTYKEKKKYQPKPAVAHTAEREQVIKLGTTNYDDFLSFIHAVQDRLMDLPVLSMDLSTVGLNYLEEEITVDVRDEFSGIVSKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILVKGNEIVLRQDIMPTTTTKWIKLHECRFHGCVDEDVFHNSRVILFNPLDACRFELMRFRTVFAEKTLPFTLRTATSVNGAEVEVQSWLRMSTGFSANRDPLTQVPCENVMIRYPVPSEWVKNFRRESVLGEKSLKAKVNRGASFGSTSVSGSEPVMRVTLGTAKYEHAFNSIVWRINRLPDKNSASGHPHCFFCHLELGSDREVPSRFANHVNVEFSMPTTSASKASVRSISVEDKTDVRKWVNYSAHYSYQVALGSIWLMLPTPFVHPTTLPLLFLLAMLTMFAW", "length": 905 }, "evidence": [ { "id": "A0A3Q1M4Q2", "url": "https://omabrowser.org/oma/group/A0A3Q1M4Q2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2" } ], "pmid": "" }, { "name": "AP-2 adaptor complex", "id": "GO:0030122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030122", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2" } ], "pmid": "" }, { "name": "AP-1 adaptor complex", "id": "GO:0030121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030121", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2" } ], "pmid": "" }, { "name": "clathrin-coated vesicle", "id": "GO:0030136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030136", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of endocytosis", "id": "GO:0030100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030100", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2" } ], "pmid": "" }, { "name": "clathrin-dependent endocytosis", "id": "GO:0072583", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072583", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q2" } ], "pmid": "" }, { "name": "synaptic vesicle endocytosis", "id": "GO:0048488", 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"MKLRGVSLAAGLSLLALSLWGQPAEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHPGLPGFPGPEGPPGPRGQKGDDGIPGPPGPKGIRGPPGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYPGPPGIQGPAGPPGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPGPPGIRGPPGPPGGVKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRDGEKGQKGDTGLPGPPGLVIPRPGTGVTVGEKGNIGLPGLPGDKGDRGFPGIQGPPGLPGPPGPAVIGPPGPPGFPGERGQKGDEGPPGISIPGSPGLDGQPGAPGPPGPPGPPGPHIPPSDKICEAGPPGPPGSPGDRGLQGEQGMKGDKGDTCFNCIGTGVSGPPGQPGLPGLPGPPGSLGFPGQKGEKGHAGATGPKGLSGIPGAPGAPGFPGPKGEPGDILTFPGMKGDKGDLGSPGAPGLPGLPGTPGQDGLPGLPGPKGEPGGMAFKGERGPPGNPGLPGLPGNRGPMGPVGFGPPGPVGEKGVQGGAGNPGQPGIPGPKGDPGQTITQPGKPGLPGHPGRDGEVGLPGEPGLPGQPGLPGIPGSKGEPGIPGIGLPGPPGPKGFPGIPGPPGAPGSPGRIGLEGPSGPPGFPGPKGEPGFGLPGPPGPPGLPGFKGILGPKGDRGFPGPQGPPGQAGLDGLPGPKGDIGPNGQPGPIGPPGLPGTGFQGPPGPPGIPGPIGQPGLHGLPGEKGDPGPPGFDVSGPPGERGSPGIPGAPGPMGPPGSPGLPGKAGASGFPGAKGEIGMMGPPGPPGPLGIPGRSGVPGLKGDDGLQGQPGLPGPAGEKGSKGEPGLPGLPGPMDPDLLGSKGEKGDPGLPGIPGVAGPKGYQGLPGDPGQPGLSGQPGLPGLAGPKGNPGLPGMPGLTGPPGLKGNMGDMGFPGPQGPKGSFGPPGVPGQPGSPGLPGQKGEKGDPGISGIGLPGLPGAKGEPGLPGYPGNPGTKGSMGETGLPGLPGTPGAKGQPGLPGFPGTPGLPGPKGISGPPGNPGLPGEPGPVGGGGRPGPPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGIPGPRGLPGLSGQKGDEGLPGIPGNPGLPGPKGEPGFHGFPGLQGPPGPPGSPGPALEGPKGSPGPQGPPGRPGFQGPPGPEGPRGLPGSGAIKGERGNPGQPGQPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDPGLPGVPGFPGMKGPSGVPGSTGPEGDPGLIGPPGPPGLPGPSGQSIVIKGDAGPPGIPGQPGLKGLQGLPGPQGLPGPIGPPGDPGRNGLPGFDGAGGRKGDPGLPGQPGTRGLDGPPGPDGLQGPPGPPGTSSIAHGFLITRHSQTTDAPQCPQGTIQVYEGFSLLYVQGNKRAHGQDLGTAGSCLRRFSTMPFMFCNINNVCNFASRNDYSYWLSTPEPMPMSMEPLKGQSIQPFISRCAVCEAPAVVIAVHSQTIQIPRCPQGWDSLWIGYSFMMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANSYSFWLATVDVSDMFSKPQSETLKAGDLRTRISRCQVCMKRT", "length": 1688, "header": "tr|A0AAA9S9L8-1|A0A3Q1M0M2_BOVIN Computationally mapped isoform of Collagen type IV alpha 5 chain OS=Bos taurus OX=9913 GN=COL4A5 PE=4 SV=2 CANONICAL=A0A3Q1M0M2-1" }, "locus": { "chromosome": "X", "start_pos": 57391329, "end_pos": 57141683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118748.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118748.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082777.2", "url": "https://www.ensembl.org/id/ENSBTAP00000082777.2" } ] } }, { "isoform_ac": "A0AAA9TX19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TX19/entry", "sequence": { "sequence": "MKLRGVSLAAGLSLLALSLWGQPAEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHPGLPGFPGPEGPPGPRGQKGDDGIPGPPGPKGIRGPPGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYPGPPGIQGPAGPPGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRDGEKGQKGDTGLPGPPGLVIPRPGTGVTVGEKGNIGLPGLPGDKGDRGFPGIQGPPGLPGPPGPAVIGPPGPPGFPGERGQKGDEGPPGISIPGSPGLDGQPGAPGPPGPPGPPGPHIPPSDKICEAGPPGPPGSPGDRGLQGEQGMKGDKGDTCFNCIGTGVSGPPGQPGLPGLPGPPGSLGFPGQKGEKGHAGATGPKGLSGIPGAPGAPGFPGPKGEPGDILTFPGMKGDKGDLGSPGAPGLPGLPGTPGQDGLPGLPGPKGEPGGMAFKGERGPPGNPGLPGLPGNRGPMGPVGFGPPGPVGEKGVQGGAGNPGQPGIPGPKGDPGQTITQPGKPGLPGHPGRDGEVGLPGEPGLPGQPGLPGIPGSKGEPGIPGIGLPGPPGPKGFPGIPGPPGAPGSPGRIGLEGPSGPPGFPGPKGEPGFGLPGPPGPPGLPGFKGILGPKGDRGFPGPQGPPGQAGLDGLPGPKGDIGPNGQPGPIGPPGLPGTGFQGPPGPPGIPGPIGQPGLHGLPGEKGDPGPPGFDVSGPPGERGSPGIPGAPGPMGPPGSPGLPGKAGASGFPGAKGEIGMMGPPGPPGPLGIPGRSGVPGLKGDDGLQGQPGLPGPAGEKGSKGEPGLPGLPGPMDPDLLGSKGEKGDPGLPGIPGVAGPKGYQGLPGDPGQPGLSGQPGLPGLAGPKGNPGLPGMPGLTGPPGLKGNMGDMGFPGPQGPKGSFGPPGVPGQPGSPGLPGQKGEKGDPGISGIGLPGLPGAKGEPGLPGYPGNPGTKGSMGETGLPGLPGTPGAKGQPGLPGFPGTPGLPGPKGISGPPGNPGLPGEPGPVGGGGRPGPPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGIPGPRGLPGLSGQKGDEGLPGIPGNPGLPGPKGEPGFHGFPGLQGPPGPPGSPGPALEGPKGSPGPQGPPGRPGPPGPEGPRGLPGSGAIKGERGNPGQPGQPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDPGLPGVPGFPGMKGPSGVPGSTGPEGDPGLIGPPGPPGLPGPSGQSIVIKGDAGPPGIPGQPGLKGLQGLPGPQGLPGPIGPPGDPGRNGLPGFDGAGGRKGDPGLPGQPGTRGLDGPPGPDGLQGPPGPPGTSSIAHGFLITRHSQTTDAPQCPQGTIQVYEGFSLLYVQGNKRAHGQDLGTAGSCLRRFSTMPFMFCNINNVCNFASRNDYSYWLSTPEPMPMSMEPLKGQSIQPFISRCAVCEAPAVVIAVHSQTIQIPRCPQGWDSLWIGYSFMMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANSYSFWLATVDVSDMFSKPQSETLKAGDLRTRISRCQVCMKRT", "length": 1626, "header": "tr|A0AAA9TX19-1|A0A3Q1M0M2_BOVIN Computationally mapped isoform of Collagen type IV alpha 5 chain OS=Bos taurus OX=9913 GN=COL4A5 PE=4 SV=1 CANONICAL=A0A3Q1M0M2-1" }, "locus": { "chromosome": "X", "start_pos": 57391329, "end_pos": 57141683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122424.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122424.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102011.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102011.1" } ] } }, { "isoform_ac": "F1N474-1", "url": "https://www.uniprot.org/uniprotkb/F1N474/entry", "sequence": { "sequence": "MKLRGVSLAAGLSLLALSLWGQPAEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHPGLPGFPGPEGPPGPRGQKGDDGIPGPPGPKGIRGPPGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYPGPPGIQGPAGPPGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPGPPGIRGPPGPPGGVKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRDGEKGQKGDTGLPGPPGLVIPRPGTGVTVGEKGNIGLPGLPGDKGDRGFPGIQGPPGLPGPPGPAVIGPPGPPGFPGERGQKGDEGPPGISIPGSPGLDGQPGAPGPPGPPGPPGPHIPPSDKICEAGPPGPPGSPGDRGLQGEQGMKGDKGDTCFNCIGTGVSGPPGQPGLPGLPGPPGSLGFPGQKGEKGHAGATGPKGLSGIPGAPGAPGFPGPKGEPGDILTFPGMKGDKGDLGSPGAPGLPGLPGTPGQDGLPGLPGPKGEPGGMAFKGERGPPGNPGLPGLPGNRGPMGPVGFGPPGPVGEKGVQGGAGNPGQPGIPGPKGDPGQTITQPGKPGLPGHPGRDGEVGLPGEPGLPGQPGLPGIPGSKGEPGIPGIGLPGPPGPKGFPGIPGPPGAPGSPGRIGLEGPSGPPGFPGPKGEPGFGLPGPPGPPGLPGFKGILGPKGDRGFPGPQGPPGQAGLDGLPGPKGDIGPNGQPGPIGPPGLPGTGFQGPPGPPGIPGPIGQPGLHGLPGEKGDPGPPGFDVSGPPGERGSPGIPGAPGPMGPPGSPGLPGKAGASGFPGAKGEIGMMGPPGPPGPLGIPGRSGVPGLKGDDGLQGQPGLPGPAGEKGSKGEPGLPGLPGPMDPDLLGSKGEKGDPGLPGIPGVAGPKGYQGLPGDPGQPGLSGQPGLPGLAGPKGNPGLPGMPGLTGPPGLKGNMGDMGFPGPQGPKGSFGPPGVPGQPGSPGLPGQKGEKGDPGISGIGLPGLPGAKGEPGLPGYPGNPGTKGSMGETGLPGLPGTPGAKGQPGLPGFPGTPGLPGPKGISGPPGNPGLPGEPGPVGGGGRPGPPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGIPGPRGLPGLSGQKGDEGLPGIPGNPGLPGPKGEPGFHGFPGLQGPPGPPGSPGPALEGPKGSPGPQGPPGRPGPTGPPGPEGPRGLPGSGAIKGERGNPGQPGQPGLPGLKGDQGPPGLQGNPGRPGLNGMKGDPGLPGVPGFPGMKGPSGVPGSTGPEGDPGLIGPPGPPGLPGPSGQSIVIKGDAGPPGIPGQPGLKGLQGLPGPQGLPGPIGPPGDPGRNGLPGFDGAGGRKGDPGLPGQPGTRGLDGPPGPDGLQGPPGPPGTSSIAHGFLITRHSQTTDAPQCPQGTIQVYEGFSLLYVQGNKRAHGQDLGTAGSCLRRFSTMPFMFCNINNVCNFASRNDYSYWLSTPEPMPMSMEPLKGQSIQPFISRCAVCEAPAVVIAVHSQTIQIPRCPQGWDSLWIGYSFMMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANSYSFWLATVDVSDMFSKPQSETLKAGDLRTRISRCQVCMKRT", "length": 1688, "header": "tr|F1N474-1|A0A3Q1M0M2_BOVIN Computationally mapped isoform of Collagen type IV alpha 5 chain OS=Bos taurus OX=9913 GN=COL4A5 PE=4 SV=5 CANONICAL=A0A3Q1M0M2-1" }, "locus": { "chromosome": "X", "start_pos": 57391329, "end_pos": 57141683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019400.8", "url": "https://www.ensembl.org/id/ENSBTAT00000019400.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019400.8", "url": "https://www.ensembl.org/id/ENSBTAP00000019400.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511602", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511602", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M2" } ], "pmid": "" }, { "name": "collagen trimer", "id": "GO:0005581", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005581", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M2" } ], "pmid": "" }, { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M2" } ], "pmid": "" }, { "name": "collagen type IV trimer", "id": "GO:0005587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005587", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "extracellular matrix structural constituent", "id": "GO:0005201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005201", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0M2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M0M2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0M2" }, { "id": "PS51403", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51403" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Collagen IV NC1", "eco_id": "ECO_0000259", "start_pos": 1467, "end_pos": 1691, "start_aa": "Gly", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 125, "end_pos": 127 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q9TTK8-1", "uniprot_ac": "Q9TTK8", "uniprot_id": "KCRU_BOVIN", "mass": { "chemical_mass": 46897.0, "monoisotopic_mass": 46897.0 }, "refseq": { "ac": "NP_776700", "name": "creatine kinase U-type, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776700" }, "gene_names": [ { "name": "CKMT1A", "type": "recommended", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ] }, { "name": "CKMT1", "type": "recommended", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ] }, { "name": "CKMT1A", "type": "synonym", "evidence": [ { "id": "NP_776700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776700" } ] }, { "name": "CKMT1B", "type": "synonym", "evidence": [ { "id": "NP_776700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776700" } ] }, { "name": "CKMT1", "type": "synonym", "evidence": [ { "id": "NP_776700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776700" } ] } ], "protein_names": [ { "name": "Creatine kinase U-type, mitochondrial", "type": "recommended", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8/entry#names_and_taxonomy" } ] }, { "name": "2.7.3.2", "type": "synonym", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8/entry#names_and_taxonomy" } ] }, { "name": "Acidic-type mitochondrial creatine kinase", "type": "synonym", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8/entry#names_and_taxonomy" } ] }, { "name": "Mia-CK", "type": "synonym", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8/entry#names_and_taxonomy" } ] }, { "name": "U-MtCK", "type": "synonym", "evidence": [ { "id": "NP_776700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776700" }, { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8/entry#names_and_taxonomy" } ] }, { "name": "Ubiquitous mitochondrial creatine kinase", "type": "synonym", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8/entry#names_and_taxonomy" } ] }, { "name": "acidic-type mitochondrial creatine kinase", "type": "synonym", "evidence": [ { "id": "NP_776700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776700" } ] }, { "name": "creatine kinase U-type, mitochondrial precursor", "type": "synonym", "evidence": [ { "id": "NP_776700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776700" } ] }, { "name": "creatine kinase U-type, mitochondrial", "type": "synonym", "evidence": [ { "id": "NP_776700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776700" } ] }, { "name": "creatine kinase, mitochondrial 1 (ubiquitous)", "type": "synonym", "evidence": [ { "id": "NP_776700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776700" } ] }, { "name": "creatine kinase, mitochondrial 1B", "type": "synonym", "evidence": [ { "id": "NP_776700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776700" } ] }, { "name": "mia-CK", "type": "synonym", "evidence": [ { "id": "NP_776700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776700" } ] }, { "name": "ubiquitous mitochondrial creatine kinase", "type": "synonym", "evidence": [ { "id": "NP_776700", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776700" } ] } ], "function": [ { "annotation": "Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6YR36", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR36#function" }, { "database": "UniProtKB", "id": "ARBA00037274", "url": "https://www.uniprot.org/uniprotkb/ARBA00037274#function" }, { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CKMT1", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8", "locus": {} } ], "crossref": [ { "id": "Q9TTK8", "url": "https://alphafold.ebi.ac.uk/entry/Q9TTK8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007502", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007502", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00716", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00716", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281692", "url": "https://www.ncbi.nlm.nih.gov/gene/281692", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "7U5I", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=7U5I&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "IPR000749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014746", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014746", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022414", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022414", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036802", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036802", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281692", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281692", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NCMASAM", "url": "https://omabrowser.org/oma/group/NCMASAM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q9TTK8", "url": "https://www.orthodb.org/?gene=Q9TTK8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11547", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11547", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11547:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11547:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00007u5i", "url": "https://www.rcsb.org/structure/pdb_00007u5i", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7U5I", "url": "https://www.rcsb.org/structure/7U5I", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00217", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00217", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02807", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02807", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-71288", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71288", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_776700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776700", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17157", "url": "https://www.rhea-db.org/rhea/17157", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6YR36", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6YR36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9TTK8-1", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGPFSRLLSARPGLRLLALAGAGSLAAGFLLRSEPVRAASERRRLYPPSAEYPDLRKHNNCMASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFAELFDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMKKVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGSVFDISNLDRLGKSEVELVQLVIDGVNFLIDCERRLERGQDIRIPPPLPNKH", "length": 416, "header": "sp|Q9TTK8-1|KCRU_BOVIN Isoform 1 of Creatine kinase U-type, mitochondrial OS=Bos taurus OX=9913 GN=CKMT1 PE=1 SV=1 CANONICAL=Q9TTK8-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YR36-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YR36/entry", "sequence": { "sequence": "MAGPFSRLLSARPGLRLLALAGAGSLAAGFLLRSEPVRAASERRRLYPPRYPLPSAEYPDLRKHNNCMASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFAELFDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMKKVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGSVFDISNLDRLGKSEVELVQLVIDGVNFLIDCERRLERGQDIRIPPPLPNKH", "length": 421, "header": "tr|A0AAF6YR36-1|KCRU_BOVIN Computationally mapped isoform of Creatine kinase U-type, mitochondrial OS=Bos taurus OX=9913 GN=CKMT1 PE=1 SV=1 CANONICAL=Q9TTK8-1" }, "locus": { "chromosome": "21", "start_pos": 55328263, "end_pos": 55323498, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009871.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009871.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009871.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009871.5" } ] } }, { "isoform_ac": "Q9TTK8-1", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8/entry#Q9TTK8-1", "sequence": { "sequence": "MAGPFSRLLSARPGLRLLALAGAGSLAAGFLLRSEPVRAASERRRLYPPSAEYPDLRKHNNCMASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFAELFDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMKKVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGSVFDISNLDRLGKSEVELVQLVIDGVNFLIDCERRLERGQDIRIPPPLPNKH", "length": 416, "header": "sp|Q9TTK8-1|KCRU_BOVIN Isoform 1 of Creatine kinase U-type, mitochondrial OS=Bos taurus OX=9913 GN=CKMT1 PE=1 SV=1 CANONICAL=Q9TTK8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 151, "end_pos": 151, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ], "site_lbl": "Ser151" }, { "start_pos": 196, "end_pos": 196, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ], "site_lbl": "Ser196" }, { "start_pos": 213, "end_pos": 213, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ], "site_lbl": "Thr213" }, { "start_pos": 232, "end_pos": 232, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ], "site_lbl": "Ser232" }, { "start_pos": 355, "end_pos": 355, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ], "site_lbl": "Thr355" }, { "start_pos": 365, "end_pos": 365, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ], "site_lbl": "Ser365" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Initiating ocular proteomics for cataloging bovine retinal proteins: microanalytical techniques permit the identification of proteins derived from a novel photoreceptor preparation.", "journal": "Exp. Eye Res.", "date": "1999", "authors": "Nishizawa Y, Komori N, Usukura J, Jackson K W, Tobin S L, Matsumoto H", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ], "reference": [ { "type": "PubMed", "id": "10433856", "url": "https://glygen.org/publication/PubMed/10433856" } ] } ], "pathway": [ { "id": "bta:281692", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281692", "resource": "KEGG Pathway" }, { "id": "R-BTA-71288", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71288", "resource": "Reactome", "description": "Creatine metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NXR0-1", "protein_name": "Creatine kinase U-type, mitochondrial", "gene_name": "CKMT1B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASTFARALSARRSAGLLAMVGAGSLAAGFLLARDTVSAGERQRRRYPPSAEYPDLRKHNNCMASNLTPAIYARLCDKATPNGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFAELFDPVIQERHNGYNPRTMKHVTDLDASKIKFGHFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVEKVTVEALNGLTGDLSGRYYRLSEMTEKEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGNVFDISNLDRLGKSEVELVQLVIDGVNYLIDCERRLEKGQDIRIPSPVPQFRH", "length": 417 }, "evidence": [ { "id": "Q9TTK8", "url": "https://omabrowser.org/oma/group/Q9TTK8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SI77-1", "protein_name": "Creatine kinase U-type, mitochondrial", "gene_name": "CKMT1A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGPFSRLLSARPGLRLLALAGAGSLAAGFLLRPEPIRAASERRRLYPPSAEYPDLRKHNNCMASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFAELFDPVIQERHNGYDPRTMKHTTDLDASKIRSGFFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMKKVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGSIFDISNLDRLGKSEVELVQLVIDGVNYLIDCERRLERGQDIRIPPPLPNKH", "length": 416 }, "evidence": [ { "id": "Q9TTK8", "url": "https://omabrowser.org/oma/group/Q9TTK8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H0U9-1", "protein_name": "Creatine kinase U-type, mitochondrial", "gene_name": "Ckmt1b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGPFSRLLSARPGLRLLALAGAGSLAAGILLRPDSVRAASERRRLYPPSAEYPDLRKHNNCMASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEIFAELFDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMKRVFERFCRGLKEVEKLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGSVFDISNLDRLGKSEVELVQLVIDGVNYLIECERRLERGQDIRIPAPLVHGKH", "length": 417 }, "evidence": [ { "id": "Q9TTK8", "url": "https://omabrowser.org/oma/group/Q9TTK8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P12532-1", "protein_name": "Creatine kinase U-type, mitochondrial", "gene_name": "CKMT1A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGPFSRLLSARPGLRLLALAGAGSLAAGFLLRPEPVRAASERRRLYPPSAEYPDLRKHNNCMASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFADLFDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGGVFDISNLDRLGKSEVELVQLVIDGVNYLIDCERRLERGQDIRIPTPVIHTKH", "length": 417 }, "evidence": [ { "id": "Q9TTK8", "url": "https://omabrowser.org/oma/group/Q9TTK8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P30275-1", "protein_name": "Creatine kinase U-type, mitochondrial", "gene_name": "Ckmt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGPFSRLLSARPGLRLLALAGAGSLTAGILLRPESVGAAAAERRRLYPPSAEYPDLRKHNNCMASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFAELFDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMKRVFERFCRGLKEVEKLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDNRFPKILENLRLQKRGTGGVDTAATGSVFDISNLDRLGKSEVELVQLVIDGVNYLIDCERRLERGQDIRIPPPLVHSKH", "length": 418 }, "evidence": [ { "id": "Q9TTK8", "url": "https://omabrowser.org/oma/group/Q9TTK8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "phosphocreatine biosynthetic process", "id": "GO:0046314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046314", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ], "pmid": "" }, { "name": "negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "id": "GO:1901029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901029", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "creatine kinase activity", "id": "GO:0004111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004111", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK8", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17157", "name": "", "equation": "creatine + ATP = N-phosphocreatine + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZIA4-1", "Q5EA61-1", "Q9TTK8-1", "Q9XSC6-1", "Q3ZBP1-1" ], "evidence": [ { "id": "17157", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17157" } ] }, { "id": "R-BTA-200326", "name": "creatine + ATP => phosphocreatine + ADP [CK octamer]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial inner membrane", "input_participant_list": [ "R-ALL-29916" ], "output_participant_list": [ "R-ALL-200351" ], "enzyme_list": [ "Q9TTK8-1", "F1MJT6-1" ], "evidence": [ { "id": "R-BTA-200326", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-200326" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-200351", "participant_name": "Pcr [cytosol]", "crossref": [ { "id": "58092", "database": "ChEBI", "url": "" }, { "id": "ZINC000003869774", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-29916", "participant_name": "CRET [cytosol]", "crossref": [ { "id": "ZINC000003861770", "database": "ZINC", "url": "" }, { "id": "57947", "database": "ChEBI", "url": "" }, { "id": "C00300", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6ZIA4", "gene_name": "CKB", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ] } ] }, { "uniprot_ac": "F1MJT6", "gene_name": "CKMT2", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "F1MJT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJT6" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "F1MJT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJT6" } ] } ] }, { "uniprot_ac": "Q3ZBP1", "gene_name": "CKMT2", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q3ZBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q3ZBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ] } ] }, { "uniprot_ac": "Q5EA61", "gene_name": "CKB", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q5EA61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA61" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q5EA61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA61" } ] } ] }, { "uniprot_ac": "Q9TTK8", "gene_name": "CKMT1", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ] } ] }, { "uniprot_ac": "Q9XSC6", "gene_name": "CKM", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q9XSC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q9XSC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9TTK8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 416, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9TTK8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9TTK8" }, { "pdb_id": "7u5i", "pdb_chain": "a/b/c/d/e/f/g/h", "start_pos": 1, "end_pos": 416, "overlap": "1.0", "method": "Electron_Microscopy", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/7u5i.pdb", "url_external": "https://www.rcsb.org/structure/7u5i" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" }, { "id": "PRU00843", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00843" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosphagen kinase C-terminal", "eco_id": "ECO_0000255", "start_pos": 158, "end_pos": 400, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" }, { "id": "PRU00842", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosphagen kinase N-terminal", "eco_id": "ECO_0000255", "start_pos": 45, "end_pos": 131, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.3.2", "ec_name": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "2.7.3.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2" }, { "id": "2.7.3.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.3.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 151, 196, 213, 232, 355, 365 ], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M028-1", "uniprot_ac": "A0A3Q1M028", "uniprot_id": "A0A3Q1M028_BOVIN", "mass": { "chemical_mass": 29832.0, "monoisotopic_mass": 29832.0 }, "refseq": {}, "gene_names": [ { "name": "TSPO", "type": "recommended", "evidence": [ { "id": "A0A3Q1M028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M028" } ] } ], "protein_names": [ { "name": "Translocator protein", "type": "recommended", "evidence": [ { "id": "A0A3Q1M028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M028/entry#names_and_taxonomy" } ] }, { "name": "Peripheral-type benzodiazepine receptor", "type": "synonym", "evidence": [ { "id": "A0A3Q1M028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M028/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides.", "evidence": [ { "database": "UniProtKB", "id": "A0A140T899", "url": "https://www.uniprot.org/uniprotkb/A0A140T899#function" }, { "database": "UniProtKB", "id": "ARBA00058548", "url": "https://www.uniprot.org/uniprotkb/ARBA00058548#function" }, { "database": "UniProtKB", "id": "A0A3Q1M028", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M028#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M028", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M028" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSPO", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M028", "locus": { "chromosome": "5", "start_pos": 113940486, "end_pos": 113922421, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018073", "url": "https://www.ensembl.org/id/ENSBTAG00000018073" } ] } } ], "crossref": [ { "id": "A0A3Q1M028", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M028", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018073", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018073", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15904", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15904", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004307", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004307", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A140T899", "url": "https://www.orthodb.org/?gene=A0A140T899", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M028", "url": "https://www.orthodb.org/?gene=A0A3Q1M028", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10057", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10057", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10057:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10057:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03073", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03073", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A140T899", "url": "https://www.uniprot.org/uniprotkb/A0A140T899", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T899-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T899-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M028", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M028", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M028-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M028-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLKRRRDLPAAPAESARRGAVRWPSGEGAAAGRPARARARGRQRPEAGAPGPAGLWAARPGLPAKPGGAGRAGQGGPREGLPPPAAQCPSWSRVLVVAELSGTAAAAAMAPPWVPAVGFTLLPSLGGFLGAQYTRGEGFRWYASLQKPPWHPPRWILAPIWGTLYSAMGYGSYMIWKELGGFSKEAVVPLGLYAGQLALNWAWPPLFFGTRQMGWALVDLLLTGGMAAATAMAWHQVSPPAACLLYPYLAWLAFAATLNYRMWQDNQVRRSGRRLSE", "length": 278, "header": "tr|A0A3Q1M028-1|A0A3Q1M028_BOVIN Isoform 1 of Translocator protein OS=Bos taurus OX=9913 GN=TSPO PE=3 SV=2 CANONICAL=A0A3Q1M028-1" }, "isoforms": [ { "isoform_ac": "A0A140T899-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T899/entry", "sequence": { "sequence": "MPGLLRSDQGGLSVSSTSGERKDACGLQLSGTAAAAAMAPPWVPAVGFTLLPSLGGFLGAQYTRGEGFRWYASLQKPPWHPPRWILAPIWGTLYSAMGYGSYMIWKELGGFSKEAVVPLGLYAGQLALNWAWPPLFFGTRQMGWALVDLLLTGGMAAATAMAWHQVSPPAACLLYPYLAWLAFAATLNYRMWQDNQVRRSGRRLSE", "length": 206, "header": "tr|A0A140T899-1|A0A3Q1M028_BOVIN Computationally mapped isoform of Translocator protein OS=Bos taurus OX=9913 GN=TSPO PE=3 SV=2 CANONICAL=A0A3Q1M028-1" }, "locus": { "chromosome": "5", "start_pos": 113940236, "end_pos": 113922463, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024060.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024060.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024060.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024060.5" } ] } }, { "isoform_ac": "A0A3Q1M028-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M028/entry", "sequence": { "sequence": "MRLKRRRDLPAAPAESARRGAVRWPSGEGAAAGRPARARARGRQRPEAGAPGPAGLWAARPGLPAKPGGAGRAGQGGPREGLPPPAAQCPSWSRVLVVAELSGTAAAAAMAPPWVPAVGFTLLPSLGGFLGAQYTRGEGFRWYASLQKPPWHPPRWILAPIWGTLYSAMGYGSYMIWKELGGFSKEAVVPLGLYAGQLALNWAWPPLFFGTRQMGWALVDLLLTGGMAAATAMAWHQVSPPAACLLYPYLAWLAFAATLNYRMWQDNQVRRSGRRLSE", "length": 278, "header": "tr|A0A3Q1M028-1|A0A3Q1M028_BOVIN Isoform 1 of Translocator protein OS=Bos taurus OX=9913 GN=TSPO PE=3 SV=2 CANONICAL=A0A3Q1M028-1" }, "locus": { "chromosome": "5", "start_pos": 113940236, "end_pos": 113927587, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073517.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073517.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066530.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066530.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M028", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M028" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M028", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M028" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M028", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M028" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M028-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 278, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M028-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M028" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BP19-1", "uniprot_ac": "E1BP19", "uniprot_id": "E1BP19_BOVIN", "mass": { "chemical_mass": 24859.0, "monoisotopic_mass": 24859.0 }, "refseq": { "ac": "XP_003585802", "name": "insulin-induced gene 2 protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585802" }, "gene_names": [ { "name": "INSIG2", "type": "recommended", "evidence": [ { "id": "E1BP19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP19" } ] }, { "name": "INSIG2", "type": "synonym", "evidence": [ { "id": "XP_003585802", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585802" } ] } ], "protein_names": [ { "name": "Insulin-induced gene protein", "type": "recommended", "evidence": [ { "id": "E1BP19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP19/entry#names_and_taxonomy" } ] }, { "name": "insulin-induced gene 2 protein", "type": "synonym", "evidence": [ { "id": "XP_003585802", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585802" } ] } ], "function": [ { "annotation": "Mediates feedback control of cholesterol synthesis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T4H5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4H5#function" }, { "database": "UniProtKB", "id": "RU241113", "url": "https://www.uniprot.org/uniprotkb/RU241113#function" }, { "database": "UniProtKB", "id": "A0A3Q1LFF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFF2#function" }, { "database": "UniProtKB", "id": "G3MWS1", "url": "https://www.uniprot.org/uniprotkb/G3MWS1#function" }, { "database": "UniProtKB", "id": "E1BP19", "url": "https://www.uniprot.org/uniprotkb/E1BP19#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP19", "url": "https://www.uniprot.org/uniprotkb/E1BP19" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INSIG2", "url": "https://www.uniprot.org/uniprotkb/E1BP19", "locus": { "chromosome": "2", "start_pos": 69800152, "end_pos": 69756859, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002112", "url": "https://www.ensembl.org/id/ENSBTAG00000002112" } ] } } ], "crossref": [ { "id": "E1BP19", "url": "https://alphafold.ebi.ac.uk/entry/E1BP19", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002112", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002112", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534440", "url": "https://www.ncbi.nlm.nih.gov/gene/534440", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025929", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025929", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534440", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534440", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SKKCGPY", "url": "https://omabrowser.org/oma/group/SKKCGPY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LFF2", "url": "https://www.orthodb.org/?gene=A0A3Q1LFF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BP19", "url": "https://www.orthodb.org/?gene=E1BP19", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MWS1", "url": "https://www.orthodb.org/?gene=G3MWS1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15301", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15301", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15301:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15301:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07281", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07281", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003585802", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585802", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LFF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LFF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4H5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4H5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T4H5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4H5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP19", "url": "https://www.uniprot.org/uniprotkb/E1BP19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP19-1", "url": "https://www.uniprot.org/uniprotkb/E1BP19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MWS1", "url": "https://www.uniprot.org/uniprotkb/G3MWS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MWS1-1", "url": "https://www.uniprot.org/uniprotkb/G3MWS1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEGETESPGPKKRGPYISSVTSRSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE", "length": 225, "header": "tr|E1BP19-1|E1BP19_BOVIN Isoform 1 of Insulin-induced gene protein OS=Bos taurus OX=9913 GN=INSIG2 PE=3 SV=1 CANONICAL=E1BP19-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LFF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFF2/entry", "sequence": { "sequence": "MAEGETESPGPKKRGPYISSVTSRSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMSTGSAPACGHPLYIRKTPFMFPLKWKEAGCRNP", "length": 245, "header": "tr|A0A3Q1LFF2-1|E1BP19_BOVIN Computationally mapped isoform of Insulin-induced gene protein OS=Bos taurus OX=9913 GN=INSIG2 PE=3 SV=1 CANONICAL=E1BP19-1" }, "locus": { "chromosome": "2", "start_pos": 69786895, "end_pos": 69764752, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082556.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082556.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056880.1", "url": "https://www.ensembl.org/id/ENSBTAP00000056880.1" } ] } }, { "isoform_ac": "A0AAA9T4H5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T4H5/entry", "sequence": { "sequence": "MAEGETESPGPKKRGPYISSVTSRSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMILKMQLTKFRICLHSHKESLEGQVLLQIGVRCRRIPQEGPVIQPERSGHVSLPT", "length": 266, "header": "tr|A0AAA9T4H5-1|E1BP19_BOVIN Computationally mapped isoform of Insulin-induced gene protein OS=Bos taurus OX=9913 GN=INSIG2 PE=3 SV=1 CANONICAL=E1BP19-1" }, "locus": { "chromosome": "2", "start_pos": 69799148, "end_pos": 69764752, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134058.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134058.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091411.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091411.1" } ] } }, { "isoform_ac": "E1BP19-1", "url": "https://www.uniprot.org/uniprotkb/E1BP19/entry", "sequence": { "sequence": "MAEGETESPGPKKRGPYISSVTSRSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE", "length": 225, "header": "tr|E1BP19-1|E1BP19_BOVIN Isoform 1 of Insulin-induced gene protein OS=Bos taurus OX=9913 GN=INSIG2 PE=3 SV=1 CANONICAL=E1BP19-1" }, "locus": { "chromosome": "2", "start_pos": 69777201, "end_pos": 69764752, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002725.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002725.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002725.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002725.4" } ] } }, { "isoform_ac": "G3MWS1-1", "url": "https://www.uniprot.org/uniprotkb/G3MWS1/entry", "sequence": { "sequence": "MAEGETESPGPKKRGPYISSVTSRSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMVLLQIGVRCRRIPQEGPVIQPERSGHVSLPT", "length": 243, "header": "tr|G3MWS1-1|E1BP19_BOVIN Computationally mapped isoform of Insulin-induced gene protein OS=Bos taurus OX=9913 GN=INSIG2 PE=3 SV=3 CANONICAL=E1BP19-1" }, "locus": { "chromosome": "2", "start_pos": 69799148, "end_pos": 69764752, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064251.4", "url": "https://www.ensembl.org/id/ENSBTAT00000064251.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053974.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053974.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534440", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534440", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6PQZ3-1", "protein_name": "Insulin-induced gene 2 protein", "gene_name": "INSIG2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEGETKSPGPKKCGPYISSVTSQSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATLVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE", "length": 225 }, "evidence": [ { "id": "E1BP19", "url": "https://omabrowser.org/oma/group/E1BP19/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q80UA9-1", "protein_name": "Insulin-induced gene 2 protein", "gene_name": "Insig2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEGETESPRPKKRGPYISSVTSQSVNVVIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVITSIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNFQFSLTLAALSVGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE", "length": 225 }, "evidence": [ { "id": "E1BP19", "url": "https://omabrowser.org/oma/group/E1BP19/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91WG1-1", "protein_name": "Insulin-induced gene 2 protein", "gene_name": "Insig2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEGETESPRPKKCGPYISSVTSQSVNVVIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVITSIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNFQFSLTLAALSVGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE", "length": 225 }, "evidence": [ { "id": "E1BP19", "url": "https://omabrowser.org/oma/group/E1BP19/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y5U4-1", "protein_name": "Insulin-induced gene 2 protein", "gene_name": "INSIG2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEGETESPGPKKCGPYISSVTSQSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE", "length": 225 }, "evidence": [ { "id": "E1BP19", "url": "https://omabrowser.org/oma/group/E1BP19/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "cholesterol metabolic process", "id": "GO:0008203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008203", "evidence": [ { "database": "UniProtKB", "id": "E1BP19", "url": "https://www.uniprot.org/uniprotkb/E1BP19" } ], "pmid": "" }, { "name": "cholesterol biosynthetic process", "id": "GO:0006695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006695", "evidence": [ { "database": "UniProtKB", "id": "E1BP19", "url": "https://www.uniprot.org/uniprotkb/E1BP19" } ], "pmid": "" }, { "name": "SREBP signaling pathway", "id": "GO:0032933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032933", "evidence": [ { "database": "UniProtKB", "id": "E1BP19", "url": "https://www.uniprot.org/uniprotkb/E1BP19" } ], "pmid": "" }, { "name": "SREBP-SCAP complex retention in endoplasmic reticulum", "id": "GO:0036316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036316", "evidence": [ { "database": "UniProtKB", "id": "E1BP19", "url": "https://www.uniprot.org/uniprotkb/E1BP19" } ], "pmid": "" }, { "name": "cellular response to insulin stimulus", "id": "GO:0032869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "evidence": [ { "database": "UniProtKB", "id": "E1BP19", "url": "https://www.uniprot.org/uniprotkb/E1BP19" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1BP19", "url": "https://www.uniprot.org/uniprotkb/E1BP19" } ], "pmid": "" }, { "name": "SREBP-SCAP-Insig complex", "id": "GO:0032937", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032937", "evidence": [ { "database": "UniProtKB", "id": "E1BP19", "url": "https://www.uniprot.org/uniprotkb/E1BP19" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1BP19", "url": "https://www.uniprot.org/uniprotkb/E1BP19" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "E1BP19", "url": "https://www.uniprot.org/uniprotkb/E1BP19" } ], "pmid": "" }, { "name": "oxysterol binding", "id": "GO:0008142", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008142", "evidence": [ { "database": "UniProtKB", "id": "E1BP19", "url": "https://www.uniprot.org/uniprotkb/E1BP19" } ], "pmid": "" }, { "name": "protein sequestering activity", "id": "GO:0140311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140311", "evidence": [ { "database": "UniProtKB", "id": "E1BP19", "url": "https://www.uniprot.org/uniprotkb/E1BP19" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 54, "end_pos": 56, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BP19-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 225, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BP19-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BP19" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 54, "end_pos": 56 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M2W6-1", "uniprot_ac": "A0A3Q1M2W6", "uniprot_id": "A0A3Q1M2W6_BOVIN", "mass": { "chemical_mass": 33924.0, "monoisotopic_mass": 33924.0 }, "refseq": {}, "gene_names": [ { "name": "PDCD1LG2", "type": "recommended", "evidence": [ { "id": "A0A3Q1M2W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2W6" } ] } ], "protein_names": [ { "name": "Programmed cell death 1 ligand 2", "type": "recommended", "evidence": [ { "id": "A0A3Q1M2W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2W6/entry#names_and_taxonomy" } ] }, { "name": "Butyrophilin B7-DC", "type": "synonym", "evidence": [ { "id": "A0A3Q1M2W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2W6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a critical role in induction and maintenance of immune tolerance to self. Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progression and cytokine production.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2W6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2W6#function" }, { "database": "UniProtKB", "id": "ARBA00094310", "url": "https://www.uniprot.org/uniprotkb/ARBA00094310#function" }, { "database": "UniProtKB", "id": "A0A3Q1NAJ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAJ6#function" }, { "database": "UniProtKB", "id": "A0AAA9TSL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSL8#function" }, { "database": "UniProtKB", "id": "A0A3Q1LGD6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGD6#function" }, { "database": "UniProtKB", "id": "G3MYP3", "url": "https://www.uniprot.org/uniprotkb/G3MYP3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2W6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2W6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDCD1LG2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2W6", "locus": { "chromosome": "8", "start_pos": 39091778, "end_pos": 39211029, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033316", "url": "https://www.ensembl.org/id/ENSBTAG00000033316" } ] } } ], "crossref": [ { "id": "A0A3Q1M2W6", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M2W6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033316", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033316", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20983", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20983", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051713", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051713", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ELYIVEH", "url": "https://omabrowser.org/oma/group/ELYIVEH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LGD6", "url": "https://www.orthodb.org/?gene=A0A3Q1LGD6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2W6", "url": "https://www.orthodb.org/?gene=A0A3Q1M2W6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NAJ6", "url": "https://www.orthodb.org/?gene=A0A3Q1NAJ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MYP3", "url": "https://www.orthodb.org/?gene=G3MYP3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR25466", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25466", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR25466:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR25466:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF22705", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22705", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-389948", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389948", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9931295", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931295", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LGD6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LGD6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGD6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2W6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2W6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2W6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2W6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NAJ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NAJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYP3", "url": "https://www.uniprot.org/uniprotkb/G3MYP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MYP3-1", "url": "https://www.uniprot.org/uniprotkb/G3MYP3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMRLPQSDPVQSMFLLLILSLGLQLQQTVALFTVTIPKEMYMVDYGSNVTLECDFDTGGPVELGILKASLQKVENDTVLLSERATLLEEQLPLGKALFLIPRIQLKDAGQYRCLIIYGIAWDYKYLTLKVKASYKKINTRHLKVPGTDEVELTCQAEGYPLAEVSWPNISIPTNTSHTKTSEGLYQVTSVLRLKPHPGRNFSCVFWNANVKELTSATIVQGPLEDPKIPSSSLLHVFILSLIVAPIFIATVVALRKRLCQKLYSGEDSTKRSATMVRREVDRATAMLFVGKKTPGRRHSLATRG", "length": 304, "header": "tr|A0A3Q1M2W6-1|A0A3Q1M2W6_BOVIN Isoform 1 of Programmed cell death 1 ligand 2 OS=Bos taurus OX=9913 GN=PDCD1LG2 PE=3 SV=2 CANONICAL=A0A3Q1M2W6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LGD6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGD6/entry", "sequence": { "sequence": "MTYIGKMHDPVQSMFLLLILSLGLQLQQTVALFTVTIPKEMYMVDYGSNVTLECDFDTGGPVELGILKASLQKVENDTVLLSERATLLEEQLPLGKALFLIPRIQLKDAGQYRCLIIYGIAWDYKYLTLKVKASYKKINTRHLKVPGTDEVELTCQAEGYPLAEVSWPNISIPTNTSHTKTSEGLYQVTSVLRLKPHPGRNFSCVFWNANVKELTSATIVQGPLEDPKIPSSSLLHVFILSLIVAPIFIATVVALRKRLCQKLYSGEDSTKRSATMVRREVDRAI", "length": 285, "header": "tr|A0A3Q1LGD6-1|A0A3Q1M2W6_BOVIN Computationally mapped isoform of Programmed cell death 1 ligand 2 OS=Bos taurus OX=9913 GN=PDCD1LG2 PE=3 SV=2 CANONICAL=A0A3Q1M2W6-1" }, "locus": { "chromosome": "8", "start_pos": 39209663, "end_pos": 39149181, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087073.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087073.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057476.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057476.2" } ] } }, { "isoform_ac": "A0A3Q1M2W6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2W6/entry", "sequence": { "sequence": "MMRLPQSDPVQSMFLLLILSLGLQLQQTVALFTVTIPKEMYMVDYGSNVTLECDFDTGGPVELGILKASLQKVENDTVLLSERATLLEEQLPLGKALFLIPRIQLKDAGQYRCLIIYGIAWDYKYLTLKVKASYKKINTRHLKVPGTDEVELTCQAEGYPLAEVSWPNISIPTNTSHTKTSEGLYQVTSVLRLKPHPGRNFSCVFWNANVKELTSATIVQGPLEDPKIPSSSLLHVFILSLIVAPIFIATVVALRKRLCQKLYSGEDSTKRSATMVRREVDRATAMLFVGKKTPGRRHSLATRG", "length": 304, "header": "tr|A0A3Q1M2W6-1|A0A3Q1M2W6_BOVIN Isoform 1 of Programmed cell death 1 ligand 2 OS=Bos taurus OX=9913 GN=PDCD1LG2 PE=3 SV=2 CANONICAL=A0A3Q1M2W6-1" }, "locus": { "chromosome": "8", "start_pos": 39210701, "end_pos": 39092739, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083184.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083184.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064381.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064381.2" } ] } }, { "isoform_ac": "A0A3Q1NAJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAJ6/entry", "sequence": { "sequence": "MMRLPQSDPVQSMFLLLILSLGLQLQQTVALFTVTIPKEMYMVDYGSNVTLECDFDTGGPVELGILKASLQKVENDTVLLSERATLLEEQLPLGKALFLIPRIQLKDAGQYRCLIIYGIAWDYKYLTLKVKASYKKINTRHLKVPGTDEVELTCQAEGYPLAEVSWPNISIPTNTSHTKTSEGLYQVTSVLRLKPHPGRNFSCVFWNANVKELTSATIVQGPLEDPKIPSSSLLHVFILSLIVAPIFIATVVALRKRLCQKLYSGEDSTKRSATMVRREVDRAERF", "length": 286, "header": "tr|A0A3Q1NAJ6-1|A0A3Q1M2W6_BOVIN Computationally mapped isoform of Programmed cell death 1 ligand 2 OS=Bos taurus OX=9913 GN=PDCD1LG2 PE=3 SV=1 CANONICAL=A0A3Q1M2W6-1" }, "locus": { "chromosome": "8", "start_pos": 39210701, "end_pos": 39116753, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084340.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084340.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068296.1", "url": 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"isoform_ac": "G3MYP3-1", "url": "https://www.uniprot.org/uniprotkb/G3MYP3/entry", "sequence": { "sequence": "MMRLPQSDPVQSMFLLLILSLGLQLQQTVALFTVTIPKEMYMVDYGSNVTLECDFDTGGPVELGILKASLQKVENDTVLLSERATLLEEQLPLGKALFLIPRIQLKDAGQYRCLIIYGIAWDYKYLTLKVKASYKKINTRHLKVPGTDEVELTCQAEGYPLAEVSWPNISIPTNTSHTKTSEGLYQVTSVLRLKPHPGRNFSCVFWNANVKELTSATIVQGPLEDPKIPSSSLLHVFILSLIVAPIFIATVVALRKRLCQKLYSGEDSTKRSATMVRREVDRAICF", "length": 286, "header": "tr|G3MYP3-1|A0A3Q1M2W6_BOVIN Computationally mapped isoform of Programmed cell death 1 ligand 2 OS=Bos taurus OX=9913 GN=PDCD1LG2 PE=3 SV=3 CANONICAL=A0A3Q1M2W6-1" }, "locus": { "chromosome": "8", "start_pos": 39210701, "end_pos": 39113170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065523.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065523.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054680.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054680.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-389948", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389948", "resource": "Reactome", "description": "Co-inhibition by PD-1" }, { "id": "R-BTA-9931295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931295", "resource": "Reactome", "description": "PD-L1(CD274) glycosylation and translocation to plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480KNE1-1", "protein_name": "Programmed cell death 1 ligand 2", "gene_name": "PDCD1LG2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFLLLILSLGMKLHHTAALFTVTVPKETYMVDHGSNVTLECDFDTGGHVELRDLKANLQKVENNTILLSEKVTLLEEQLPLGKALFHIPQVHVRDAGQYRCFIIYGTAWDYKYLTLKVKASYKKIKTRNLKVPGTDEIELTCQGEGYPLAEVSWPNISVPANTSYTKTSEGLYQVTSVLRLKPHPGRNFSCVFWNANMKEFTLAIIVPGDMETHKTPASSLLRVFIPSFIIALMFIATMILLRKQLCQKFYPGKDTAKRSVITVRREVNRAI", "length": 272 }, "evidence": [ { "id": "A0A3Q1M2W6", "url": 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"MIFLLLMLSLELQLHQIAALFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPTWLLHIFIPFCIIAFIFIATVIALRKQLCQKLYSSKDTTKRPVTTTKREVNSAI", "length": 273 }, "evidence": [ { "id": "A0A3Q1M2W6", "url": "https://omabrowser.org/oma/group/A0A3Q1M2W6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9WUL5-1", "protein_name": "Programmed cell death 1 ligand 2", "gene_name": "Pdcd1lg2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLLLPILNLSLQLHPVAALFTVTAPKEVYTVDVGSSVSLECDFDRRECTELEGIRASLQKVENDTSLQSERATLLEEQLPLGKALFHIPSVQVRDSGQYRCLVICGAAWDYKYLTVKVKASYMRIDTRILEVPGTGEVQLTCQARGYPLAEVSWQNVSVPANTSHIRTPEGLYQVTSVLRLKPQPSRNFSCMFWNAHMKELTSAIIDPLSRMEPKVPRTWPLHVFIPACTIALIFLAIVIIQRKRI", "length": 247 }, "evidence": [ { "id": "A0A3Q1M2W6", "url": 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"A0A3Q1M2W6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2W6" } ], "pmid": "" }, { "name": "T cell costimulation", "id": "GO:0031295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031295", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2W6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2W6" } ], "pmid": "" }, { "name": "negative regulation of type II interferon production", "id": "GO:0032689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032689", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2W6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2W6" } ], "pmid": "" }, { "name": "cellular response to lipopolysaccharide", "id": "GO:0071222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2W6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2W6" } ], "pmid": "" }, { "name": "positive regulation of T cell proliferation", "id": "GO:0042102", "url": 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"protein_names": [ { "name": "Mitochondrial ribonuclease P catalytic subunit", "type": "recommended", "evidence": [ { "id": "A0A3Q1M1T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9/entry#names_and_taxonomy" } ] }, { "name": "3.1.26.5", "type": "synonym", "evidence": [ { "id": "A0A3Q1M1T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9/entry#names_and_taxonomy" } ] }, { "name": "Mitochondrial ribonuclease P protein 3", "type": "synonym", "evidence": [ { "id": "A0A3Q1M1T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial ribonuclease P catalytic subunit", "type": "synonym", "evidence": [ { "id": "NP_001422054", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422054" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRORP", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9", "locus": { "chromosome": "21", "start_pos": 45528538, "end_pos": 45395476, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009682", "url": "https://www.ensembl.org/id/ENSBTAG00000009682" } ] } } ], "crossref": [ { "id": "A0A3Q1M1T9", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M1T9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009682", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009682", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18718", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18718", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532995", "url": "https://www.ncbi.nlm.nih.gov/gene/532995", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VKEPIRY", "url": "https://omabrowser.org/oma/group/VKEPIRY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR13547", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13547", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13547:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13547:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16953", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16953", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001422054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422054", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LGH4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LGH4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1T9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1T9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFB5", "url": "https://www.uniprot.org/uniprotkb/E1BFB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFB5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PZG3", "url": "https://www.uniprot.org/uniprotkb/F6PZG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PZG3-1", "url": "https://www.uniprot.org/uniprotkb/F6PZG3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTFYFTGIRSFPKLWKSNSYFGLSSSHSYLSLFLKDCYGIRNQEKCFSVKTMSAQNTKAMNLLIAKARCVRKLDESSNKQVSADSSHMFAAGAAKKRSQMNPSSKDPVLPPVENIIQLPTKPLNSEEWDKLKEEFKEKANFENWIILQMVKCHSSVDVAKSVLAWVAAKNSGIVGYDLLVKYLYLCVFHKQTSEIIDVYEIMKARYKRLESGAYTLLMRGLIYTDRWREALLLLEDLKKVMIPSKKNYDDCIQGALFHQDVNVAWNLYQELLSHDIVPMLETLKAFFDFGKDMKDDQYSNKLHNILLYLRNNQLYPGESFAHSIKTWFESIPGEQWKGQFTTIQQSGQCLGCGKTVESIHLSSEEYEFLKAKIMRDVIDGGDQYKKTTPQELKRFQNFVKYHPPFDVVIDGLNVAKMFPKARESQVLLNVVSHLAKQNLQVLVLGRKHMLTQNSRWRRVEMEKMQKQASFFFADNISEDDPFLLYATLHSGNHCKFITKDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVSKHPGAKITFQHILSYDTVVQTTGDSWHIPYDDDLVERYSYEVPTKWLCLHRKT", "length": 584, "header": "tr|A0A3Q1M1T9-1|A0A3Q1M1T9_BOVIN Isoform 1 of Mitochondrial ribonuclease P catalytic subunit OS=Bos taurus OX=9913 GN=PRORP PE=3 SV=1 CANONICAL=A0A3Q1M1T9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LGH4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGH4/entry", "sequence": { "sequence": "MTFYFTGIRSFPKLWKSNSYFGLSSSHSYLSLFLKDCYGIRNQEKCFSVKTMSAQNTKAMNLLIAKARCVRKLDESSNKQVSADSSHMFAAGAAKKRSQMNPSSKDPVLPPVENIIQLPTKPLNSEEWDKLKEEFKEKANFENWIILQMVKCHSSVDVAKSVLAWVAAKNSGIVGYDLLVKYLYLCVFHKQTSEIIDVYEIMKARYKRLESGAYTLLMRGLIYTDRWREALLLLEDLKKVMIPSKKNYDDCIQGALFHQDVNVAWNLYQELLSHDIVPMLETLKAFFDFGKDMKDDQYSNKLHNILLYLRNNQLYPGESFAHSIKTWFESIPGEQWKGQFTTIQQSGQCLGCGKTVESIHLSSEEYEFLKAKIMRDVIDGGDQYKKTTPQELKRFQNFVKYHPPFDVVIDGLNVAKMFPKARESQVGLPVCLLSFFARTLFLEQLLNVVSHLAKQNLQVLVLGRKHMLTQNSRWRRVEMEKMQKQASFFFADNISEDDPFLLYATLHSGNHCKFITKDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVSKHPGAKITFQHILSYDTVVQTTGDSWHIPYDDDLVERYSYEVPTKWLCLHRKT", "length": 602, "header": "tr|A0A3Q1LGH4-1|A0A3Q1M1T9_BOVIN Computationally mapped isoform of Mitochondrial ribonuclease P catalytic subunit OS=Bos taurus OX=9913 GN=PRORP PE=3 SV=3 CANONICAL=A0A3Q1M1T9-1" }, "locus": { "chromosome": "21", "start_pos": 45527534, "end_pos": 45396572, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075835.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075835.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057544.3", "url": "https://www.ensembl.org/id/ENSBTAP00000057544.3" } ] } }, { "isoform_ac": "A0A3Q1M1T9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9/entry", "sequence": { "sequence": "MTFYFTGIRSFPKLWKSNSYFGLSSSHSYLSLFLKDCYGIRNQEKCFSVKTMSAQNTKAMNLLIAKARCVRKLDESSNKQVSADSSHMFAAGAAKKRSQMNPSSKDPVLPPVENIIQLPTKPLNSEEWDKLKEEFKEKANFENWIILQMVKCHSSVDVAKSVLAWVAAKNSGIVGYDLLVKYLYLCVFHKQTSEIIDVYEIMKARYKRLESGAYTLLMRGLIYTDRWREALLLLEDLKKVMIPSKKNYDDCIQGALFHQDVNVAWNLYQELLSHDIVPMLETLKAFFDFGKDMKDDQYSNKLHNILLYLRNNQLYPGESFAHSIKTWFESIPGEQWKGQFTTIQQSGQCLGCGKTVESIHLSSEEYEFLKAKIMRDVIDGGDQYKKTTPQELKRFQNFVKYHPPFDVVIDGLNVAKMFPKARESQVLLNVVSHLAKQNLQVLVLGRKHMLTQNSRWRRVEMEKMQKQASFFFADNISEDDPFLLYATLHSGNHCKFITKDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVSKHPGAKITFQHILSYDTVVQTTGDSWHIPYDDDLVERYSYEVPTKWLCLHRKT", "length": 584, "header": "tr|A0A3Q1M1T9-1|A0A3Q1M1T9_BOVIN Isoform 1 of Mitochondrial ribonuclease P catalytic subunit OS=Bos taurus OX=9913 GN=PRORP PE=3 SV=1 CANONICAL=A0A3Q1M1T9-1" }, "locus": { "chromosome": "21", "start_pos": 45527534, "end_pos": 45396572, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081942.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081942.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063712.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063712.1" } ] } }, { "isoform_ac": "A0AAA9SPN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPN3/entry", "sequence": { "sequence": "MTFYFTGIRSFPKLWKSNSYFGLSSSHSYLSLFLKDCYGIRNQEKCFSVKTMSAQNTKAMNLLIAKARCVRKLDESSNKQVSADSSHMFAAGAAKKRSQMNPSSKDPVLPPVENIIQLPTKPLNSEEWDKLKEEFKEKANFENWIILQMVKCHSSVDVAKSVLAWVAAKNSGIVGYDLLVKYLYLCVFHKQTSEIIDVYEIMKARYKRLESGAYTLLMRGLIYTDRWREALLLLEDLKKVMIPSKKNYDDCIQGALFHQDVNVAWNLYQELLSHDIVPMLETLKAFFDFGKDMKDDQYSNKLHNILLYLRNNQLYPGESFAHSIKTWFESGQCLGCGKTVESIHLSSEEYEFLKAKIMRDVIDGGDQYKKTTPQELKRFQNFVKYHPPFDVVIDGLNVAKMFPKARESQVLLNVVSHLAKQNLQVLVLGRKHMLTQNSRWRRVEMEKMQKQASFFFADNISEDDPFLLYATLHSGNHCKFITKDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVSKHPGAKITFQHILSYDTVVQTTGDSWHIPYDDDLVERYSYEVPTKWLCLHRKT", "length": 568, "header": "tr|A0AAA9SPN3-1|A0A3Q1M1T9_BOVIN Computationally mapped isoform of Mitochondrial ribonuclease P catalytic subunit OS=Bos taurus OX=9913 GN=PRORP PE=3 SV=1 CANONICAL=A0A3Q1M1T9-1" }, "locus": { "chromosome": "21", "start_pos": 45527534, "end_pos": 45396572, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108955.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108955.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085957.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085957.1" } ] } }, { "isoform_ac": "E1BFB5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFB5/entry", "sequence": { "sequence": "MTFYFTGIRSFPKLWKSNSYFGLSSSHSYLSLFLKDCYGIRNQEKCFSVKTMSAQNTKAMNLLIAKARCVRKLDESSNKQVSADSSHMFAAGAAKKRSQMNPSSKDPVLPPVENIIQLPTKPLNSEEWDKLKEEFKEKANFENWIILQMVKCHSSVDVAKSVLAWVAAKNSGIVGYDLLVKYLYLCVFHKQTSEIIDVYEIMKARYKRLESGAYTLLMRGLIYTDRWREALLLLEDLKKVMIPSKKNYDDCIQGALFHQDVNVAWNLYQELLSHDIVPMLETLKAFFDFGKDMKDDQYSNKLHNILLYLRNNQLYPGESFAHSIKTWFESIPGEQWKGQFTTIQQSGQCLGCGKTVESIHLSSEEYEFLKAKIMRDVIDGGDQYKKTTPQELKRFQNFVKYHPPFDVVIDGLNVAKMFPKARESQVLLNVVSHLAKQNLQVLVLGRKHMLTQNSRWRRVEMEKMQKQASFFFADNISEDDPFLLYATLHSGNHCKFITKDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVSKHPGAKITFQHILSYDTVVQTTGDSWHIPYDDDLVERYSYEVPTKWLCLHRKTGRVTSWPGRIVWGLHLPET", "length": 603, "header": "tr|E1BFB5-1|E1BFB5_BOVIN Computationally mapped isoform of Mitochondrial ribonuclease P catalytic subunit OS=Bos taurus OX=9913 GN=PRORP PE=3 SV=4 CANONICAL=A0A3Q1M1T9-1" }, "locus": { "chromosome": "21", "start_pos": 45533952, "end_pos": 45396572, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012771.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012771.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012771.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012771.7" } ] } }, { "isoform_ac": "F6PZG3-1", "url": "https://www.uniprot.org/uniprotkb/F6PZG3/entry", "sequence": { "sequence": "MTFYFTGIRSFPKLWKSNSYFGLSSSHSYLSLFLKDCYGIRNQEKCFSVKTMSAQNTKAMNLLIAKARCVRKLDESSNKQVSADSSHMFAAGAAKKRSQMNPSSKDPVLPPVENIIQLPTKPLNSEEWDKLKEEFKEKANFENWIILQMVKCHSSVDVAKSVLAWVAAKNSGIVGYDLLVKYLYLCVFHKQTSEIIDVYEIMKARYKRLESGAYTLLMRGLIYTDRWREALLLLEDLKKVMIPSKKNYDDCIQGALFHQDVNVAWNLYQELLSHDIVPMLETLKAFFDFGKDMKDDQYSNKLHNILLYLRNNQLYPGESFAHSIKTWFESIPGEQWKGQFTTIQQSGQCLGCGKTVESIHLSSEEYEFLKAKIMRDVIDGGDQYKKTTPQLLNVVSHLAKQNLQVLVLGRKHMLTQNSRWRRVEMEKMQKQASFFFADNISEDDPFLLYATLHSGNHCKFITKDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVSKHPGAKITFQHILSYDTVVQTTGDSWHIPYDDDLVERYSYEVPTKWLCLHRKT", "length": 548, "header": "tr|F6PZG3-1|A0A3Q1M1T9_BOVIN Computationally mapped isoform of Mitochondrial ribonuclease P catalytic subunit OS=Bos taurus OX=9913 GN=PRORP PE=3 SV=2 CANONICAL=A0A3Q1M1T9-1" }, "locus": { "chromosome": "21", "start_pos": 45527534, "end_pos": 45396572, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052489.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052489.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051057.3", "url": "https://www.ensembl.org/id/ENSBTAP00000051057.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A480Y4Z5-1", "protein_name": "Mitochondrial ribonuclease P catalytic subunit", "gene_name": "PRORP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTFYFTGIRSFPKLWKSNPYLGLGPGHAYLSLLLKDCYGIRNYKWFSLKPMSPQNTKAMNLLIAKARYVRKRDEGSNKQVSADSPHLFAAGAAKKRSEMNPQSKDYFRPPVRNIVQLPTKPLNSEEWNKLKEDFKGKTNFENWILSQMVKYHSSIDVAKSVLAWVAANNNGVIGYDLLVKYLYLCVFHKETAEIIDVYEIMKARYKRLESGGYTLLIRGLIHTDRWREALLLLEDLKKVIIPSKMNYNDCIQGALLHQDVNVAWKLHQELLGHDIVPMLETLKAFFDFGKGIKDDEYSNKLQDILLYLRNNQLYPGESFAHSIKTWFESIPGEQWKGQFTTIQQSGQCLGCGKTVESIHLSSEEYEFLKERIMRDVIDGGDQYRKTTPQELKRFQNFVKYCPPFDIVIDGLNVAKMFPKARESQVLLDVVSQLAKQNLKVLVLGRKHMLMQNSRWRKDDMEKVQKQASYFFADNISEDDPFLLYATLHSGNHCKFITKDLMRDHKACLPDAKTQRLFFKWQQGHQLAIISRHPGSRITFQHILSYDTVVQTTGDSWHIPYDEDLVERYSYEVPTKWLCLHRKT", "length": 583 }, "evidence": [ { "id": "A0A3Q1M1T9", "url": "https://omabrowser.org/oma/group/A0A3Q1M1T9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "B5DF07-1", "protein_name": "Mitochondrial ribonuclease P catalytic subunit", "gene_name": "Prorp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTFYLSGFRSFLKLWKSNPYFELGPATSSASFFLGVHCVIGNQQRWFSVKPTTPPNSKILNLLVTKARTLKKGNDSNKQASSGPHYFAAGEAKKRSHLSGNPQNQGHTLPVKSTVQLPTKPLNSEEWDKLKEDFKGKASFEDFVISQMTRSCSSVDVAKSLLAWVAAKNNGIVGYNLLVKYLYLCVFHKQTSEVIDVYEIMKAKYKSLESGGYTLLIRGLIHSDRWREALLLLEDIKKVMVPSKKNYGDCIQGALLHQDVNVAWSLYQELVGHNLIPLLETLKAFFDHGKDMNDDQYSNQLLDILLYLRNNQLYPGESFAHSIKTWFESIPGRQWKGQFTTIQKSGQCSSCGRAIESIHLSPEEYEFLKETIMRDVIDGGDQYKKTTPQELKRFERFVKSCPPFDIVIDGLNVAKMFPKGRESQNLLGIVSQLAQQNLQLLVLGRKHMLRPSSQWRKDEMEQVRKQAHCFFADNISEDDPFLLYATLNSGSHCKFITKDLLRDHKACLPDARAQRLFFKWQQGHQLAITKGFLKSKLTFQHILSYDTVVQTTGDTWHIPYDEDLVPRSSCEVPTKWLCLQRKTPAPC", "length": 587 }, "evidence": [ { "id": "A0A3Q1M1T9", "url": "https://omabrowser.org/oma/group/A0A3Q1M1T9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O15091-1", "protein_name": "Mitochondrial ribonuclease P catalytic subunit", "gene_name": "PRORP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAAKERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQLSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLLLNVVSQLAKRNLRLLVLGRKHMLRRSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQLAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDEDLVERCSCEVPTKWLCLHQKT", "length": 583 }, "evidence": [ { "id": "A0A3Q1M1T9", "url": "https://omabrowser.org/oma/group/A0A3Q1M1T9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8JZY4-1", "protein_name": "Mitochondrial ribonuclease P catalytic subunit", "gene_name": "Prorp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTFYLSGFRSIPKLWKSNPYFELGPATSSTPFFLCAIGNQQRWFSVKPTTPPNSKALNLLDTKARTHRKGNDNNGQVSSDPHYFAAGAAKKRSHIGANPQNQGHALPVRSSVQLPTKPLNSAEWDKLKEDFKGKASFEDFIISQMARNCCSVDVAKSLLAWVAAKNNGIVGYNLLVKYLYLCVFHKQTSEVIDVYEIMKAKYKSLESGGYTLLIRGLIHSDRWRESLLLLEDIKKVMVPSKKNYGDCIQGALLHQDVNTAWNLYQELIGHNLIPPLETLKAFFDYGKDINDDHYSDKLLDILLYLRNNQLYPGESFAHSIKTWFESIPGRQWKGQFTTIQKSGQCSGCGRTIEPIHLSPEEYEFLKEKIMRDVIDGGDQYKKTTPQELKRFESFVNSCPPFDIVIDGLNVAKMFPKGRESQNLLGVVSQLAQQNLQLLVLGRKHMLRPSSQWRKEEMEQVRKQAHCFFADNISEDDPFLLYATLNSGNHCKFITKDLLRDHKACLPDARTQRLFFKWQQGHQLAIMKGFQKSKLTFQHILSYDTVVQRTGDSWHIPYDEDLVQRSSCEVPTKWLCLQRKTPDPC", "length": 584 }, "evidence": [ { "id": "A0A3Q1M1T9", "url": "https://omabrowser.org/oma/group/A0A3Q1M1T9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W413-1", "protein_name": "Mitochondrial ribonuclease P catalytic subunit", "gene_name": "mldr", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MYNLRLLRNLLPIAGHAHPRWLASQHKRRPQPGSLPADRLDQLRSDLFERRHELSGAEWTEVRRSLVDGYKHINGHNVDAVILGVCSAPNQLSLAKSYVEFLRSRGSKPNAATLGRLLRVYNAAYHERPLSEAEQSEILQICRSLQAEHETLDASSCENVIHGLVATSGDDWQRGLPLLEMMKVTSTPSVAAYSALAEKAFSVATPEQELAWRLLEEMATARKPPKCEVYLALLNRLANETAQLPAQLSLLLQFLERHEILVSQRVAIRLQELSSQVPQLLHTRTTHLGGLGKCQSCQQHLQPVAISDEEFRQLSECFLERVLIRRDVFQRSTPEEVARFKKFVEKTAPYDCVIDGLNVAYSTGTKKTPQQLAKLVATVVRHFREQDKRVLVLGREHMRNWSKQAMHYVHCNASLFLTSNLSHDDPFLLYATLRSGQETDFFSRDLMRSHAFHLGTELKPIFRRWQQEHQFSLVTQTQTGQIIVKEPVRHRLCAHQVADTWHVPYCAQYTPHPTDSFEVPANWLCIQMKEQTIPATKTKTKTTR", "length": 544 }, "evidence": [ { "id": "A0A3Q1M1T9", "url": "https://omabrowser.org/oma/group/A0A3Q1M1T9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "X1WBZ5-1", "protein_name": "Mitochondrial ribonuclease P catalytic subunit", "gene_name": "prorp", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGFVAMSKSRTCMKHLCTWVVNPLYFRPDSPPHNITNAVRLIINPHTRYYTTKRDKQAQSPNEKGFTPRTRPAFPHSVFSAGAARKRAEFLKHKSGLDTENDDTPVRVRDSPNMVLPDRPLTPSEWTNLKKDFSRPELFEKVMMENLVRANVDVNIAKSLLSYVVQDKGTLSYEILLRYLTICVRAGHHSEVFDAYDIMRSCFKSLDLGASALFIKGFSQTDRWKEAISMLQDMKKALLPSPRNYGDVIAGAVLHGDSETSWKLYDELLELGLVPGQDTWQCLFQSGITQRGHEDKLFDVLSYMRDNQIYPEKPLMETIKAWFESLPDQKWRGKFSSVTPSGDCRNCKALLESIQLTEVEYAQLKHNVMEKVIEGGDVFNKSNPEELKSFKSFVKQRPPFDIVIDGLNVAKMLPHAAQSETLLAVVSELEQQSLNILVLGRKHMLRHSRNWDRQNMSLIKQKAHCFFTEDISEDDPYLLYAALNSGVHCKFLSRDLMRDHKACLPDSATRCLFFKWQRGHQLVISHYTPGKRVRFERILSYDTIIQTNGSSWHIPYDQKAEDRASYEVPQKWLCLTRD", "length": 578 }, "evidence": [ { "id": "A0A3Q1M1T9", "url": "https://omabrowser.org/oma/group/A0A3Q1M1T9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9" } ], "pmid": "" }, { "name": "mitochondrial nucleoid", "id": "GO:0042645", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042645", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9" } ], "pmid": "" }, { "name": "mitochondrial ribonuclease P complex", "id": "GO:0030678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030678", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "tRNA processing", "id": "GO:0008033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008033", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9" } ], "pmid": "" }, { "name": "tRNA 5'-leader removal", "id": "GO:0001682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001682", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9" } ], "pmid": "" }, { "name": "mitochondrial tRNA 5'-end processing", "id": "GO:0097745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097745", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9" } ], "pmid": "" }, { "name": "ribonuclease P activity", "id": "GO:0004526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004526", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 475, "end_pos": 477, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M1T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T9" }, { "id": "PF16953", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16953" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PRORP", "eco_id": "ECO_0000259", "start_pos": 343, "end_pos": 579, "start_aa": "Ile", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.26.5", "ec_name": "Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.", "evidence": [ { "id": "3.1.26.5", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.26.5" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 475, "end_pos": 477 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { 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"total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M0U3-1", "uniprot_ac": "A0A3Q1M0U3", "uniprot_id": "A0A3Q1M0U3_BOVIN", "mass": { "chemical_mass": 95877.0, "monoisotopic_mass": 95877.0 }, "refseq": {}, "gene_names": [ { "name": "SORBS3", "type": 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Classification" ] }, { "id": "IPR035609", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035609", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050384", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050384", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TVCNGYL", "url": "https://omabrowser.org/oma/group/TVCNGYL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LIZ0", "url": "https://www.orthodb.org/?gene=A0A3Q1LIZ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0U3", "url": "https://www.orthodb.org/?gene=A0A3Q1M0U3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14167:SF54", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14167:SF54", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02208", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02208", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-445355", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-445355", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LIZ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": 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"MLLCPLGRPQSPPPALLGRGHAEEQLSSPDPSMQAPPYSLPAGLSLDDFIPGHLLAHVGSSTRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGYFQPRRDASRHPDPAWYQTWPGPGSRPPGNQKTPASQHSQKWSATWTKDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDSPRDWYRRMFKQIHRKMPDLQLDWTFEEAPKVDSSCATSADSRHPGPQQRPPARPNQMSPLSGRSWDVSEESLRSTFSCSPGAPSSLHQTSKQVLRRQEKADNVWTEESWNQFLQELETGQKPKKPLVDDPVEKPSQPIEVLLERELAKLSAELDKDLRAIETGQPSPKSSQAPRRSREPRPPARPASAWSSSSPNALYPSSSLSPHRMADGGSPFLGRRDFVYPSSARDPSASDPGGSPARKEEKKRKAARLKFDFQAQSPKELTLKKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYNFKGDLEVELSFRKGERICLIRKVNEHWYEGRISGTGRQGIFPASYVQVTREPRVRLCDDGPQLPASPRLPTARLVCRPSSPLTPRSPADPTDWGVQTSPRRTGFSLPPQESRPQTQSLSTPRSALSHPGGSSHPPDLGTSSSTTSEIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPVDRLPALPPWGSSNKNQLPNLIETKGRLCLEGFLPCHCSLLAILSASLPPAGPGSVVGDGHDSSLVFAAWQEVLPEGSLFPKAAKPCAWAVLIIPAALVPRKSGASKDWPVPDVFQGNGYVLSSCQPSSPQVPPGSRECKINLGTRDLAFLSFFFGLW", "length": 866, "header": "tr|A0A3Q1M0U3-1|A0A3Q1M0U3_BOVIN Isoform 1 of Vinexin OS=Bos taurus OX=9913 GN=SORBS3 PE=1 SV=1 CANONICAL=A0A3Q1M0U3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LIZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LIZ0/entry", "sequence": { "sequence": "MARIPGVGRSSASPSLENKEEHERDVALNHQDPDRGHAEEQLSSPDPSMQAPPYSLPAGLSLDDFIPGHLLAHVGSSTRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGYFQPRRDASRHPDPAWYQTWPGPGSRPPGNQKTPASQHSQKWSATWTKDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDSPRDWYRRMFKQIHRKMPDLQLDWTFEEAPKVDSSCATSADSRHPGPQQRPPARPNQMSPLSGRSWDVSEESLRSTFSCSPGAPSSLHQTSKQVLRRQEKADNVWTEESWNQFLQELETGQKPKKPLVDDPVEKPSQPIEVLLERELAKLSAELDKDLRAIETGQPSPKSSQAPRRSREPRPPARPASAWSSSSPNALYPSSSLSPHRMADGGSPFLGRRDFVYPSSARDPSASDPGGSPARKEEKKRKAARLKFDFQAQSPKELTLKKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYNFKGDLEVELSFRKGERICLIRKVNEHWYEGRISGTGRQGIFPASYVQVTREPRVRLCDDGPQLPASPRLPTARLVCRPSSPLTPRSPADPTDWGVQTSPRRTGFSLPPQESRPQTQSLSTPRSALSHPGGSSHPPDLGTSSSTTSEIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV", "length": 725, "header": "tr|A0A3Q1LIZ0-1|A0A3Q1M0U3_BOVIN Computationally mapped isoform of Vinexin OS=Bos taurus OX=9913 GN=SORBS3 PE=1 SV=3 CANONICAL=A0A3Q1M0U3-1" }, "locus": { "chromosome": "8", "start_pos": 69877818, "end_pos": 69849565, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078426.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078426.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059212.3", "url": "https://www.ensembl.org/id/ENSBTAP00000059212.3" } ] } }, { "isoform_ac": "A0A3Q1M0U3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3/entry", "sequence": { "sequence": "MLLCPLGRPQSPPPALLGRGHAEEQLSSPDPSMQAPPYSLPAGLSLDDFIPGHLLAHVGSSTRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGYFQPRRDASRHPDPAWYQTWPGPGSRPPGNQKTPASQHSQKWSATWTKDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDSPRDWYRRMFKQIHRKMPDLQLDWTFEEAPKVDSSCATSADSRHPGPQQRPPARPNQMSPLSGRSWDVSEESLRSTFSCSPGAPSSLHQTSKQVLRRQEKADNVWTEESWNQFLQELETGQKPKKPLVDDPVEKPSQPIEVLLERELAKLSAELDKDLRAIETGQPSPKSSQAPRRSREPRPPARPASAWSSSSPNALYPSSSLSPHRMADGGSPFLGRRDFVYPSSARDPSASDPGGSPARKEEKKRKAARLKFDFQAQSPKELTLKKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYNFKGDLEVELSFRKGERICLIRKVNEHWYEGRISGTGRQGIFPASYVQVTREPRVRLCDDGPQLPASPRLPTARLVCRPSSPLTPRSPADPTDWGVQTSPRRTGFSLPPQESRPQTQSLSTPRSALSHPGGSSHPPDLGTSSSTTSEIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPVDRLPALPPWGSSNKNQLPNLIETKGRLCLEGFLPCHCSLLAILSASLPPAGPGSVVGDGHDSSLVFAAWQEVLPEGSLFPKAAKPCAWAVLIIPAALVPRKSGASKDWPVPDVFQGNGYVLSSCQPSSPQVPPGSRECKINLGTRDLAFLSFFFGLW", "length": 866, "header": "tr|A0A3Q1M0U3-1|A0A3Q1M0U3_BOVIN Isoform 1 of Vinexin OS=Bos taurus OX=9913 GN=SORBS3 PE=1 SV=1 CANONICAL=A0A3Q1M0U3-1" }, "locus": { "chromosome": "8", "start_pos": 69878632, "end_pos": 69852039, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073421.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073421.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066857.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066857.1" } ] } }, { "isoform_ac": "A0AAA9S254-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S254/entry", "sequence": { "sequence": "MLLCPLGRPQSPPPALLGRGHAEEQLSSPDPSMQAPPYSLPAGLSLDDFIPGHLLAHVGSSTRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGYFQPRRDASRHPDPAWYQTWPGPGSRPPGNQKTPASQHSQKWSATWTKDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDSPRDWYRRMFKQIHRKMPDLQLDWTFEEAPKVDSSCATSADSRHPGPQQRPPARPNQMSPLSGRSWDVSEESLRSTFSCSPGAPSSLHQTSKQVLRRQEKADNVWTEESWNQFLQELETGQKPKKPLVDDPVEKPSQPIEVLLERELAKLSAELDKDLRAIETGQPSPKSSQAPRRSREPRPPARPASAWSSSSPNALYPSSSLSPHRMADGGSPFLGRRDFVYPSSARDPSASDPGGSPARKEEKKRKAARLKFDFQAQSPKELTLKKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYNFKGDLEVELSFRKGERICLIRKVNEHWYEGRISGTGRQGIFPASYVQVTREPRVRLCDDGPQLPASPRLPTARLVCRPSSPLTPRSPADPTDWGVQTSPRRTGFSLPPQESRPQTQSLSTPRSALSHPGGSSHPPDLGTSSSTTSEIHWTPCLQEDPEIWDIPWKLCSPGVSGLRGNSEPTQDGVGNRALMGGREDPPYTYPSPRT", "length": 709, "header": "tr|A0AAA9S254-1|A0A3Q1M0U3_BOVIN Computationally mapped isoform of Vinexin OS=Bos taurus OX=9913 GN=SORBS3 PE=1 SV=2 CANONICAL=A0A3Q1M0U3-1" }, "locus": { "chromosome": "8", "start_pos": 69877925, "end_pos": 69852039, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109130.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109130.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077387.2", "url": "https://www.ensembl.org/id/ENSBTAP00000077387.2" } ] } }, { "isoform_ac": "A0AAA9SIG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIG2/entry", "sequence": { "sequence": "MARIPGVGRSSASPSLENKEEHERDVALNHQDPDRGHAEEQLSSPDPSMQAPPYSLPAGLSLDDFIPGHLLAHVGSSTRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGYFQPRRDASRHPDPAWYQTWPGPGSRPPGNQKTPASQHSQKWSATWTKDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDSPRDWYRRMFKQIHRKMPVDSSCATSADSRHPGPQQRPPARPNQMSPLSGRSWDVSEESLRSTFSCSPGAPSSLHQTSKQVLRRQEKADNVWTEESWNQFLQELETGQKPKKPLVDDPVEKPSQPIEVLLERELAKLSAELDKDLRAIETGQPSPKSSQAPRRSREPRPPARPASAWSSSSPNALYPSSSLSPHRMADGGSPFLGRRDFVYPSSARDPSASDPGGSPARKEEKKVRDFRLLNVLALAFRELTLKKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYNFKGDLEVELSFRKGERICLIRKVNEHWYEGRISGTGRQGIFPASYVQVTREPRVRLCDDGPQLPASPRLPTARLVCRPSSPLTPRSPADPTDWGVQTSPRRTGFSLPPQESRPQTQSLSTPRSALSHPGGSSHPPDLGTSSSTTSEIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV", "length": 711, "header": "tr|A0AAA9SIG2-1|A0A3Q1M0U3_BOVIN Computationally mapped isoform of Vinexin OS=Bos taurus OX=9913 GN=SORBS3 PE=1 SV=1 CANONICAL=A0A3Q1M0U3-1" }, "locus": { "chromosome": "8", "start_pos": 69877818, "end_pos": 69849565, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089999.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089999.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082338.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082338.1" } ] } }, { "isoform_ac": "F6Q0V8-1", "url": "https://www.uniprot.org/uniprotkb/F6Q0V8/entry", "sequence": { "sequence": "MLLCPLGRPQSPPPALLGRGHAEEQLSSPDPSMQAPPYSLPAGLSLDDFIPGHLLAHVGSSTRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGYFQPRRDASRHPDPAWYQTWPGPGSRPPGNQKTPASQHSQKWSATWTKDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDSPRDWYRRMFKQIHRKMPDLQLDWTFEEAPKVDSSCATSADSRHPGPQQRPPARPNQMSPLSGRSWDVSEESLRSTFSCSPGAPSSLHQTSKQVLRRQEKADNVWTEESWNQFLQELETGQKPKKPLVDDPVEKPSQPIEVLLERELAKLSAELDKDLRAIETGQPSPKSSQAPRRSREPRPPARPASAWSSSSPNALYPSSSLSPHRMADGGSPFLGRRDFVYPSSARDPSASDPGGSPARKEEKKRKAARLKFDFQAQSPKELTLKKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYNFKGDLEVELSFRKGERICLIRKVNEHWYEGRISGTGRQGIFPASYVQVTREPRVRLCDDGPQLPASPRLPTARLVCRPSSPLTPRSPADPTDWGVQTSPRRTGFSLPPQESRPQTQSLSTPRSALSHPGGSSHPPDLGTSSSTTSEIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV", "length": 709, "header": "tr|F6Q0V8-1|A0A3Q1M0U3_BOVIN Computationally mapped isoform of Vinexin OS=Bos taurus OX=9913 GN=SORBS3 PE=1 SV=2 CANONICAL=A0A3Q1M0U3-1" }, "locus": { "chromosome": "8", "start_pos": 69877818, "end_pos": 69852039, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045370.4", "url": "https://www.ensembl.org/id/ENSBTAT00000045370.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042765.3", "url": "https://www.ensembl.org/id/ENSBTAP00000042765.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-445355", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-445355", "resource": "Reactome", "description": "Smooth Muscle Contraction" } ], "orthologs": [ { "uniprot_canonical_ac": "O60504-1", "protein_name": "Vinexin", "gene_name": "SORBS3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQGPPRSLRAGLSLDDFIPGHLQSHIGSSSRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGGYTPRRDASQHPDPAWYQTWPGPGSKPSASTKIPASQHTQNWSATWTKDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFEEPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV", "length": 671 }, "evidence": [ { "id": "A0A3Q1M0U3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0U3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9R1Z8-1", "protein_name": "Vinexin", "gene_name": "Sorbs3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARILGVGRSSASSLNNKEDNESDVALLSPKDPNRVHTKEQLAHPASSNLDPSMQGLPAGLSLDDFIPGHLRTHIGSSSRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGCPPPRRDGSLNPDPAWYQTWPGPGSRPSMSPKPPASQHAQNWSATWTKDSKRQDKRWVKYEGIGPVDESGMPIAPRSSVDSPRDWYRRMFQQIHRKMPDLQLDWTLEDPPKVVSARASSAEPRHLGTLQRPASRPGTTETSSGRNWNHSEETSRNTFNYNFRPSSSGLHPPNQVPRHREKVENVWTEDSWNQFLHELETGHKPKKPLVDDPVEKPAQPIEVLLERELAKLSAELDKDLRAIETRLPSPKNSQAPRRPLEQPGLEQQPSARLSSAWRPNSPHAPYFSSSRPLSPHRMADGGGSPFLGRRDFVYPSSAREPSASERGSSPSRKEEKKRKAARLKFDFQAQSPKELSLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGDAVAQYTFKGDLEVELSFRKGERICLIRKVNEHWYEGRITGTGRQGIFPASYVQINREPRLRLCDDGPQLPASPNPTTTAHLSSHSHPSSIPVDPTDWGGRTSPRRSAFPFPITLQEPRSQTQSLNTPGPTLSHPRATSRPINLGPSSPNTEIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV", "length": 733 }, "evidence": [ { "id": "A0A3Q1M0U3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0U3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "anchoring junction", "id": "GO:0070161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070161", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3" } ], "pmid": "" }, { "name": "cell-substrate junction", "id": "GO:0030055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030055", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3" } ], "pmid": "" }, { "name": "vinculin binding", "id": "GO:0017166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017166", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3" } ], "pmid": "" }, { "name": "positive regulation of stress fiber assembly", "id": "GO:0051496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051496", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3" } ], "pmid": "" }, { "name": "cell-substrate adhesion", "id": "GO:0031589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031589", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M0U3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 866, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M0U3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0U3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M0U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 419, "end_pos": 478, "start_aa": "Lys", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1M0U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U3" }, { "id": "PS50831", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50831" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SoHo", "eco_id": "ECO_0000259", "start_pos": 147, "end_pos": 215, "start_aa": "Asp", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BP52-1", "uniprot_ac": "E1BP52", "uniprot_id": "E1BP52_BOVIN", "mass": { "chemical_mass": 82743.0, "monoisotopic_mass": 82743.0 }, "refseq": { "ac": "XP_024857351", "name": "protein MTSS 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857351" }, "gene_names": [ { "name": "MTSS1", "type": "recommended", "evidence": [ { "id": "E1BP52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ] }, { "name": "MTSS1", "type": "synonym", "evidence": [ { "id": "XP_024857351", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857351" } ] } ], "protein_names": [ { "name": "MTSS I-BAR domain containing 1", "type": "synonym", "evidence": [ { "id": "E1BP52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP52/entry#names_and_taxonomy" } ] }, { "name": "protein MTSS 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024857351", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857351" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTSS1", "url": "https://www.uniprot.org/uniprotkb/E1BP52", "locus": { "chromosome": "14", "start_pos": 15553664, "end_pos": 15391608, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020407", "url": "https://www.ensembl.org/id/ENSBTAG00000020407" } ] } } ], "crossref": [ { "id": "E1BP52", "url": "https://alphafold.ebi.ac.uk/entry/E1BP52", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020407", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020407", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07643", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07643", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22060", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22060", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523498", "url": "https://www.ncbi.nlm.nih.gov/gene/523498", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013606", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013606", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QKKAKKX", "url": "https://omabrowser.org/oma/group/QKKAKKX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LL14", "url": "https://www.orthodb.org/?gene=A0A3Q1LL14", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LLN6", "url": "https://www.orthodb.org/?gene=A0A3Q1LLN6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MNC6", "url": "https://www.orthodb.org/?gene=A0A3Q1MNC6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BP52", "url": "https://www.orthodb.org/?gene=E1BP52", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15708", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15708", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15708:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15708:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08397", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08397", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024857351", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857351", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LL14", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LL14-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLN6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLN6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNC6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNC6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNC6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP52-1", "url": "https://www.uniprot.org/uniprotkb/E1BP52-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKVDALGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHGSHSHSPSSHYRYRGSSLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESHVGPVGASLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPSGGGPAAAGGAPAATEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVAESPQGVTSVPTSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQERDPPSATASPGQVPESDPADVSPRDVPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 762, "header": "tr|E1BP52-1|E1BP52_BOVIN Isoform 1 of MTSS I-BAR domain containing 1 OS=Bos taurus OX=9913 GN=MTSS1 PE=3 SV=3 CANONICAL=E1BP52-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LL14-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL14/entry", "sequence": { "sequence": "MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHGSHSHSPSSHYRYRGSSLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQDWAKPGPYDQPLVNTLQRRKEKREPDPSGGGPAAAGGAPAATEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVAESPQGVTSVPTSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQERDPPSATASPGQVPESDPADVSPRDVPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 693, "header": "tr|A0A3Q1LL14-1|E1BP52_BOVIN Computationally mapped isoform of MTSS I-BAR domain containing 1 OS=Bos taurus OX=9913 GN=MTSS1 PE=3 SV=1 CANONICAL=E1BP52-1" }, "locus": { "chromosome": "14", "start_pos": 15550746, "end_pos": 15392588, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068659.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068659.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057452.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057452.1" } ] } }, { "isoform_ac": "A0A3Q1LLN6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLN6/entry", "sequence": { "sequence": "MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHGSHSHSPSSHYRYRGSSLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQNSSSSASSEASETCQSVSECSSPTSVSSGSTMGAWASTEKLSNGFSHYSLSSESHVGPVGASLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPSGGGPAAAGGAPAATEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVAESPQGVTSVPTSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQERDPPSATASPGQVPESDPADVSPRDVPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 798, "header": "tr|A0A3Q1LLN6-1|E1BP52_BOVIN Computationally mapped isoform of MTSS I-BAR domain containing 1 OS=Bos taurus OX=9913 GN=MTSS1 PE=3 SV=2 CANONICAL=E1BP52-1" }, "locus": { "chromosome": "14", "start_pos": 15550746, "end_pos": 15392588, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070757.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070757.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057694.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057694.2" } ] } }, { "isoform_ac": "A0A3Q1MNC6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNC6/entry", "sequence": { "sequence": "MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKVDALGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHGSHSHSPSSHYRYRGSSLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQDWAKPGPYDQPLVNTLQRRKEKREPDPSGGGPAAAGGAPAATEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVAESPQGVTSVPTSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQERDPPSATASPGQVPESDPADVSPRDVPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 697, "header": "tr|A0A3Q1MNC6-1|E1BP52_BOVIN Computationally mapped isoform of MTSS I-BAR domain containing 1 OS=Bos taurus OX=9913 GN=MTSS1 PE=3 SV=2 CANONICAL=E1BP52-1" }, "locus": { "chromosome": "14", "start_pos": 15550746, "end_pos": 15392588, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074791.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074791.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071022.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071022.2" } ] } }, { "isoform_ac": "E1BP52-1", "url": "https://www.uniprot.org/uniprotkb/E1BP52/entry", "sequence": { "sequence": "MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKVDALGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHGSHSHSPSSHYRYRGSSLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESHVGPVGASLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPSGGGPAAAGGAPAATEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVAESPQGVTSVPTSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQERDPPSATASPGQVPESDPADVSPRDVPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 762, "header": "tr|E1BP52-1|E1BP52_BOVIN Isoform 1 of MTSS I-BAR domain containing 1 OS=Bos taurus OX=9913 GN=MTSS1 PE=3 SV=3 CANONICAL=E1BP52-1" }, "locus": { "chromosome": "14", "start_pos": 15550746, "end_pos": 15392588, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027195.8", "url": "https://www.ensembl.org/id/ENSBTAT00000027195.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027195.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027195.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 590, "start_aa": "Thr", "end_pos": 590, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr590", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287BF57-1", "protein_name": "MTSS I-BAR domain containing 1", "gene_name": "MTSS1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKVDALGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHGSHSHSPSSHYRYRGSSLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLPSESQVGPVGASLSPHCLPASRLLPRVTSVHLPDYAHYHTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDSSGGGPTAAGGAPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSAGEGPQGVTGMPSSTWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQERDPPSATASPGQTAESDPADLSPREAPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 762 }, "evidence": [ { "id": "E1BP52", "url": "https://omabrowser.org/oma/group/E1BP52/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0ABK0LKU5-1", "protein_name": "MTSS I-BAR domain containing 1", "gene_name": "Mtss1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGFAVSVMGTPRPRAQCSRPESVSCPRRAGKMEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAANQNSSSSASSEASETCQSVSECSSPTSVSSGSTMGAWVSTDKLSNGFSHYSLSSESHAGPVGAGPFPHCLPASRLLPRVTSIHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREADSSGGGPTATAGPPAAAEEAQRPRSMTVSAAPRPGEDMEACDELALALSRGLQLDAQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEAEQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPSPPDGPEERGEHSPESPSVGEGPQGVSNIPSSLWSGHAPINPPLPGPKPSIPEEHRQAIPESEAEDQERDPSSTSVSPGPIPESDPADLSPRESPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 826 }, "evidence": [ { "id": "E1BP52", "url": "https://omabrowser.org/oma/group/E1BP52/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O43312-1", "protein_name": "Protein MTSS 1", "gene_name": "MTSS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSMPSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADLSPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 755 }, "evidence": [ { "id": "E1BP52", "url": "https://omabrowser.org/oma/group/E1BP52/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R1S4-1", "protein_name": "Protein MTSS 1", "gene_name": "Mtss1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKNKSSDTLKLQKKAKKVDAQGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAANQLSNGFSHCSLSSESHAGPVGAGPFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDSNGGGPTTTGGPPAGAEEAQRPRSMTVSAATRPGEEMAACEELTLALSRGLQLDVQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEAEQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPSPPDGPEERGEHSPESPSAGEGPQGVSNIPSSLWSGQAPVNPPLPGPKPSIPEEHRQAIPESEAEDQERDPPSATVSPGPIPESDPADLSPRESPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 759 }, "evidence": [ { "id": "E1BP52", "url": "https://omabrowser.org/oma/group/E1BP52/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "positive regulation of actin filament bundle assembly", "id": "GO:0032233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032233", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" }, { "name": "plasma membrane organization", "id": "GO:0007009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007009", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" }, { "name": "adherens junction maintenance", "id": "GO:0034334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034334", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" }, { "name": "negative regulation of epithelial cell proliferation", "id": "GO:0050680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050680", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" }, { "name": "glomerulus morphogenesis", "id": "GO:0072102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072102", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" }, { "name": "cellular response to fluid shear stress", "id": "GO:0071498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071498", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" }, { "name": "renal tubule morphogenesis", "id": "GO:0061333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061333", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" }, { "name": "epithelial cell proliferation involved in renal tubule morphogenesis", "id": "GO:2001013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001013", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" }, { "name": "nephron tubule epithelial cell differentiation", "id": "GO:0072160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072160", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" }, { "name": "actin monomer binding", "id": "GO:0003785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003785", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" }, { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" }, { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "E1BP52", "url": "https://www.uniprot.org/uniprotkb/E1BP52" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BP52-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 762, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BP52-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BP52" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BP52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP52" }, { "id": "PS51338", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51338" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IMD", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 254, "start_aa": "Met", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BP52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP52" }, { "id": "PS51082", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51082" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WH2", "eco_id": "ECO_0000259", "start_pos": 734, "end_pos": 751, "start_aa": "Gln", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 590 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 285, "end_pos": 287 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q9TTR8-1", "uniprot_ac": "Q9TTR8", "uniprot_id": "COT1_BOVIN", "mass": { "chemical_mass": 46284.0, "monoisotopic_mass": 46284.0 }, "refseq": { "ac": "NP_786998", "name": "COUP transcription factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786998" }, "gene_names": [ { "name": "NR2F1", "type": "recommended", "evidence": [ { "id": "Q9TTR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" } ] }, { "name": "COUP-TFI", "type": "synonym", "evidence": [ { "id": "NP_786998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786998" } ] }, { "name": "COUP-TF", "type": "synonym", "evidence": [ { "id": "NP_786998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786998" } ] }, { "name": "NR2F1", "type": "synonym", "evidence": [ { "id": "NP_786998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786998" } ] }, { "name": "TFCOUP1", "type": "synonym", "evidence": [ { "id": "Q9TTR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" } ] } ], "protein_names": [ { "name": "COUP transcription factor 1", "type": "recommended", "evidence": [ { "id": "Q9TTR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8/entry#names_and_taxonomy" } ] }, { "name": "COUP transcription factor 1", "type": "synonym", "evidence": [ { "id": "NP_786998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786998" } ] }, { "name": "COUP transcription factor I", "type": "synonym", "evidence": [ { "id": "NP_786998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786998" }, { "id": "Q9TTR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8/entry#names_and_taxonomy" } ] }, { "name": "COUP-TF I", "type": "synonym", "evidence": [ { "id": "NP_786998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786998" }, { "id": "Q9TTR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8/entry#names_and_taxonomy" } ] }, { "name": "COUP-TF1", "type": "synonym", "evidence": [ { "id": "NP_786998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786998" }, { "id": "Q9TTR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8/entry#names_and_taxonomy" } ] }, { "name": "Nuclear receptor subfamily 2 group F member 1", "type": "synonym", "evidence": [ { "id": "Q9TTR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8/entry#names_and_taxonomy" } ] }, { "name": "chicken ovalbumin upstream promoter-transcription factor", "type": "synonym", "evidence": [ { "id": "NP_786998", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786998" } ] } ], "function": [ { "annotation": "Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9TTR8", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8#function" } ] }, { "annotation": "Results suggest that COUP-TF exerts a tonic inhibition on steroidogenesis by repressing StAR protein expression and that activators of aldosterone biosynthesis lift this inhibition in part by repressing COUP-TF levels.", "evidence": [ { "database": "RefSeq", "id": "NP_786998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786998" }, { "database": "PubMed", "id": "15375188", "url": "https://glygen.org/publication/PubMed/15375188" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9TTR8", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NR2F1", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8", "locus": { "chromosome": "7", "start_pos": 93062127, "end_pos": 93052305, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017599", "url": "https://www.ensembl.org/id/ENSBTAG00000017599" } ] } } ], "crossref": [ { "id": "Q9TTR8", "url": "https://alphafold.ebi.ac.uk/entry/Q9TTR8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017599", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017599", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06948", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06948", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06958", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06958", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "327684", "url": "https://www.ncbi.nlm.nih.gov/gene/327684", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050274", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050274", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:327684", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:327684", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QWKEEHR", "url": "https://omabrowser.org/oma/group/QWKEEHR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LM85", "url": "https://www.orthodb.org/?gene=A0A3Q1LM85", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q9TTR8", "url": "https://www.orthodb.org/?gene=Q9TTR8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24083", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24083", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00104", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00104", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00105", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00105", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-383280", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_786998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786998", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LM85", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LM85-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM85-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9TTR8", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9TTR8-1", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS", "length": 424, "header": "sp|Q9TTR8-1|COT1_BOVIN Isoform 1 of COUP transcription factor 1 OS=Bos taurus OX=9913 GN=NR2F1 PE=2 SV=1 CANONICAL=Q9TTR8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LM85-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM85/entry", "sequence": { "sequence": "MAMVVSSWRDPQDDVQQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS", "length": 400, "header": "tr|A0A3Q1LM85-1|COT1_BOVIN Computationally mapped isoform of COUP transcription factor 1 OS=Bos taurus OX=9913 GN=NR2F1 PE=2 SV=1 CANONICAL=Q9TTR8-1" }, "locus": { "chromosome": "7", "start_pos": 93061324, "end_pos": 93052400, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068662.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068662.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057961.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057961.1" } ] } }, { "isoform_ac": "Q9TTR8-1", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8/entry#Q9TTR8-1", "sequence": { "sequence": "MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS", "length": 424, "header": "sp|Q9TTR8-1|COT1_BOVIN Isoform 1 of COUP transcription factor 1 OS=Bos taurus OX=9913 GN=NR2F1 PE=2 SV=1 CANONICAL=Q9TTR8-1" }, "locus": { "chromosome": "7", "start_pos": 93061324, "end_pos": 93052400, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000023401.6", "url": "https://www.ensembl.org/id/ENSBTAT00000023401.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000023401.6", "url": "https://www.ensembl.org/id/ENSBTAP00000023401.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 64, "start_aa": "Thr", "end_pos": 64, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr64", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Chicken ovalbumin upstream promoter-transcription factor is a negative regulator of steroidogenesis in bovine adrenal glomerulosa cells.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2005-01", "authors": "Buholzer Carine F, Arrighi Jean-Fran\u00e7ois, Abraham Shahnaz, Piguet Vincent, Capponi Alessandro M, Casal And\u00e9rs J", "evidence": [ { "database": "RefSeq", "id": "NP_786998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786998" } ], "reference": [ { "type": "PubMed", "id": "15375188", "url": "https://glygen.org/publication/PubMed/15375188" } ] } ], "pathway": [ { "id": "bta:327684", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:327684", "resource": "KEGG Pathway" }, { "id": "R-BTA-383280", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "resource": "Reactome", "description": "Nuclear Receptor transcription pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RNX7-1", "protein_name": "Nuclear receptor subfamily 2 group F member 1", "gene_name": "NR2F1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS", "length": 422 }, "evidence": [ { "id": "Q9TTR8", "url": "https://omabrowser.org/oma/group/Q9TTR8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O09018-1", "protein_name": "COUP transcription factor 2", "gene_name": "Nr2f2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGSQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ", "length": 414 }, "evidence": [ { "id": "Q9TTR8", "url": "https://omabrowser.org/oma/group/Q9TTR8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P10589-1", "protein_name": "COUP transcription factor 1", "gene_name": "NR2F1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS", "length": 423 }, "evidence": [ { "id": "Q9TTR8", "url": "https://omabrowser.org/oma/group/Q9TTR8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P16376-1", "protein_name": "Steroid receptor seven-up, isoform A", "gene_name": "svp", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MCASPSTAPGFFNPRPQSGAELSAFDIGLSRSMGLGVPPHSAWHEPPASLGGHLHAASAGPGTTTGSVATGGGGTTPSSVASQQSAVIKQDLSCPSLNQAGSGHHPGIKEDLSSSLPSANGGSAGGHHSGSGSGSGSGVNPGHGSDMLPLIKGHGQDMLTSIKGQPTGCGSTTPSSQANSSHSQSSNSGSQIDSKQNIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYSCRGSRNCPIDQHHRNQCQYCRLKKCLKMGMRREAVQRGRVPPTQPGLAGMHGQYQIANGDPMGIAGFNGHSYLSSYISLLLRAEPYPTSRYGQCMQPNNIMGIDNICELAARLLFSAVEWAKNIPFFPELQVTDQVALLRLVWSELFVLNASQCSMPLHVAPLLAAAGLHASPMAADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTTGKLLDILYKDVPALLTKVSALLGKGSTASNDDVLAVVRDHLDELNRQEQESQAQQQAPLHLAAFMNCVAGVEAAVQQAEQAQVPTSSASASVSAPLVPSAGSAFSSCQAKSAGSEMDLLASLYAQAQATPPSSGGGDASGHNNSSGLGASLPTQSQSGSSSRNLTASPLSTSLATAPAPASASAPAPVPTSSVAQVPVPAPVPVTSSASSSSLGGGAYQTPSAAAAAAAMFHYQTPPRAAFGSAFDMFHHSTPFGVGVGHAHALAHSSGSGSASFGSPSYRYSPYSLAGSRWQL", "length": 746 }, "evidence": [ { "id": "Q9TTR8", "url": "https://omabrowser.org/oma/group/Q9TTR8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q06725-1", "protein_name": "Nuclear receptor subfamily 2 group F member 1-A", "gene_name": "nr2f1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAMVVSVWRDPQEDVAGGPPSGPNPAAQPAREQQQAASAAPHTPQTPSQPGPPSTPGTAGDKGSQNSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCIKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQ", "length": 411 }, "evidence": [ { "id": "Q9TTR8", "url": "https://omabrowser.org/oma/group/Q9TTR8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q9TTR8", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q9TTR8", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "Q9TTR8", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q9TTR8", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9TTR8", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q9TTR8", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "Q9TTR8", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q9TTR8", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" } ], "pmid": "" }, { "name": "nuclear receptor activity", "id": "GO:0004879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004879", "evidence": [ { "database": "UniProtKB", "id": "Q9TTR8", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "Q9TTR8", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "Q9TTR8", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9TTR8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 424, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9TTR8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9TTR8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q9TTR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" }, { "id": "PRU01189", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU01189" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NR LBD", "eco_id": "ECO_0000255", "start_pos": 185, "end_pos": 411, "start_aa": "Tyr", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "Q9TTR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTR8" }, { "id": "PRU00407", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00407" } ], "ann_type": "Nucleotide_Binding_Annotation", "uniprotkb_annotation": "Nuclear receptor", "eco_id": "ECO_0000255", "start_pos": 84, "end_pos": 159, "start_aa": "His", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 64 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 118, "end_pos": 120 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M3L3-1", "uniprot_ac": "A0A3Q1M3L3", "uniprot_id": "A0A3Q1M3L3_BOVIN", "mass": { "chemical_mass": 312994.0, "monoisotopic_mass": 312994.0 }, "refseq": { "ac": "XP_005225342", "name": "trinucleotide repeat-containing gene 18 protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225342" }, "gene_names": [ { "name": "TNRC18", "type": "recommended", "evidence": [ { "id": "A0A3Q1M3L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3" } ] }, { "name": "TNRC18", "type": "synonym", "evidence": [ { "id": "XP_005225342", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225342" } ] } ], "protein_names": [ { "name": "Trinucleotide repeat containing 18", "type": "synonym", "evidence": [ { "id": "A0A3Q1M3L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3/entry#names_and_taxonomy" } ] }, { "name": "trinucleotide repeat-containing gene 18 protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005225342", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225342" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3L3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TNRC18", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3", "locus": { "chromosome": "25", "start_pos": 38968564, "end_pos": 38879079, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037400", "url": "https://www.ensembl.org/id/ENSBTAG00000037400" } ] } } ], "crossref": [ { "id": "ENSBTAG00000037400", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037400", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04714", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04714", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20469", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20469", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526616", "url": "https://www.ncbi.nlm.nih.gov/gene/526616", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001025", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001025", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048924", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048924", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052429", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052429", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526616", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526616", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LHDGKHC", "url": "https://omabrowser.org/oma/group/LHDGKHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LN24", "url": "https://www.orthodb.org/?gene=A0A3Q1LN24", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LQX0", "url": "https://www.orthodb.org/?gene=A0A3Q1LQX0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVI3", "url": "https://www.orthodb.org/?gene=A0A3Q1LVI3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3L3", "url": "https://www.orthodb.org/?gene=A0A3Q1M3L3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MMX6", "url": "https://www.orthodb.org/?gene=A0A3Q1MMX6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BLK1", "url": "https://www.orthodb.org/?gene=E1BLK1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12505", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12505", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12505:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12505:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01426", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01426", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21744", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21744", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005225342", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225342", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LN24", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LN24-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQX0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQX0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVI3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVI3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3L3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3L3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMX6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMX6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLK1", "url": "https://www.uniprot.org/uniprotkb/E1BLK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLK1-1", "url": "https://www.uniprot.org/uniprotkb/E1BLK1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGRDFGPPRSVHGPPPPLLSGLAMDSHRVGAATAGRLPASGLPGPLPPGKYMAGLNLHPHPGEAFLGSFVAGGMGPAASSHGSPVPLPSDLSFRSPTPSNLPMVQLWAAHAHEGFSHLPSGLYPPYLHLSHLEPPSSGSPLLSQLGQPSIFDTQKDGFYLPAPGAPGAPGTLHSHAASSRTPGGHSSGTSTKGASREGPAKERTGRSGEPPPLFGKKDPRAREEAAGPRGVVDLTQEARAEGRQDRGPPRLLERLSPFLAEPGPLRAPGSATAESKGKNPPPPLSLSLCNGTGTGDVGLPALIAEGSRGTKDIARQDESARLRRAEALLPGPCPCPSPLPPPPPPPSKGPPAPSAASGAFAAPQPAPTGVYTIFPAAASREPGREHRVVAPTFVPSVEAFDERPGPIQIASQARDSRAREREVGRPGVLQGPPGSPRPPPDRPESLREKSSVIRSLKRPPPADAPPARAARASPDPRAYLPAKELLKPEAEPRPCERALRGPAATAASQQAAKLFGLEPGRPPPPAGPEHKWKPFELGNFATTQMAVLAAQHHHASRAEEEAAAAASKKAYLDPGGALPRAVATCARPGADIHAAAHGPGEASAMQSLIKYSGSFAREAVTVRPGGCGKKSPFGGLGTMKPEPAPTAAPRAQTRLPHPGGPAASSGRQLKRDPERPESAKAFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGGSGRLAPGLADQERSLSLSNVKGHGRADEDCGDDRARHREERLLGARLDRDQEKLLRESKELADLARLHPTSCAANGLNPNLMVTGGPALAGSGRWSADPAAHLATHPWLPRSGSTSMWLAGHPYGLGPPSLHQGMTPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSDHLPHFAELMERAAVPPLWPALYPPGRSSLHHAQQLQLFSQQHFLRQQEFLYLQQQAAQALELQRSAQLVQERLKAQEQRAEMEEKVSKRSLEAAGKAGLGAAGPGLLPRKPPGLSTGPTGTYGKAMSPPPSPRASPVAALKAKVIQKLEDVSKPPAYAYPATPSSHPSSPPPASPPPTPGIARKEEAPENVVEKKDLELEKEAPSPFQALFSDIPARYPFQALPPHYGRPYPFLLQPTAAADADGLAPDVPLPADGPERLALSPEDKPLRLSPSKVPEPLREVPDEEPLVEREVKAEVEDMDEEPAQLPSLESPLTLPPEDALAAPSPAGGLLEAQALSASGQGPEEPPGCPDFAEGAEARVDSPGLTESCAAAPDLGPRLTPEPLVEAKEEPVEVPVDMPVAVPAPLAEVVPGEEDLAQTAPSEPRPSLELPDCDVPAGEGECPRLEAPEAGPVPGGTCFLEEAGSEEFLPSLEDPLAGMNALAAAAELPQARPLPSPGTGAPALETLEAAQSLVLEQSFLHGITLLSEIAELELEKRSQEAAGAERGPPVRPSLESLLAASSHVLKEVLDGPFVDPLKNLRLPRELNPNKKYSWMQKKDERMYAMKSSLESMDAMELDFRMRLAEVQRQYKEKQRELVKLQRRRDSEDRREEPHRSLARRGPGRPRKRTHALSALSPPRKRGKSRIHSGKLSGKPLLTSDDYELGAGMRKRHKGPEEDHDALGGAGKARGRNQPWDEHETSSDLMSQLKIKKKKMASDQEQLASKLDKALSLTKQDKLKSPFKFSDGSGGKSKASGGCGRYLTPYDSLLGKDRKALAKGLSLSLKASREGKHKRAAKARKMEVGFKARGQPKSTHSPFASEVSSYSYNTDSEEEEEFLKDEWAAQGPSSSKLTPSLLCGMVAKNSKPAGGPKLTRRGLAGARTLKPKPAAGRKQPFCLLLQEVEPRSSFSDSSEDSFDQDESSEEEDEDDEPEEDEAAGGYRLGARERALSPGLEESGLGLLARFAASALPSPTVGPSLSVVQLEAKQKARKKEERQSLMGTEFEYTDSESEVKVRKRSPAGLLRPKKGLGEPGPALAAPGARTPGPSSPDKAKLAAEKGRKARKSRGPKEPGPEAGPEASDDDLWTRRRSERIFLHDASAPPAPSSAAPTAAKPGRCAKAGLPSPRKDAGRARDRKDPRKKKKGKEAGSGASLPPPRVPALPTEARAPHTSSPASAKRSKAKAKAKEVKKENRGKGGAVSKLMESMAAEEDFEPNQDSSFSEDEHLPRGGAAERPLTPAPRSCIIDKDELKDGLRVLIPMDDKLLYAGHVQTLHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRYLPQGTRIAAYWSQQYRCLYPGTVVRGLLGLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDAGESKDGAAAAPEEPGAKARGRGRKPSTKAKSDRAAVLEEGGSTDDVPSTPLVLEPVSTPGSKKSPPEPVDKRAKTPKARPAPPQPSPAPSTFASCPAPEPFGELPTPAAALAPAPLVTVPITMPATRPKPKKARAAEESASKGARRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREEPKGLLGLGSYAPAAGSPEPKAARPKAADGDLAQEPAVGLAFEDSGTPKSPDKGQAEQDGAEESESGSSSGGSSSDSSSSSSETEGEEDGQGGGGRTCSASSSRASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDDSSCSSDDEAAPAPTAGPSAPPALPSKAPKQAGKARSPGKKAPAPAAQAPPPQPTPPLPPKAQAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRPNLPYIGRIQSMWESWGSNMVVRVKWFYHPEETSPGKRLHEGQPWDQKSGRSLPASLRASSQRKDFMERALYQSSHVDENDVQTVSHKCLVVGLEQYEQMLQTKKHQDSEGLYYLAGTYEPTTGMIFSTDGVPVLC", "length": 2960, "header": "tr|A0A3Q1M3L3-1|A0A3Q1M3L3_BOVIN Isoform 1 of Trinucleotide repeat containing 18 OS=Bos taurus OX=9913 GN=TNRC18 PE=4 SV=1 CANONICAL=A0A3Q1M3L3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LN24-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN24/entry", "sequence": { "sequence": "MDGRDFGPPRSVHGPPPPLLSGLAMDSHRVGAATAGRLPASGLPGPLPPGKYMAGLNLHPHPGEAFLGSFVAGGMGPAASSHGSPVPLPSDLSFRSPTPSNLPMVQLWAAHAHEGFSHLPSGLYPPYLHLSHLEPPSSGSPLLSQLGQPSIFDTQKDGFYLPAPGAPGAPGTLHSHAASSRTPGGHSSGTSTKGASREGPAKERTGRSGEPPPLFGKKDPRAREEAAGPRGVVDLTQEARAEGRQDRGPPRLLERLSPFLAEPGPLRAPGSATAESKGKNPPPPLSLSLCNGTGTGDVGLPALIAEGSRGTKDIARQDESARLRRAEALLPGPCPCPSPLPPPPPPPSKGPPAPSAASGAFAAPQPAPTGVYTIFPAAASREPGREHRVVAPTFVPSVEAFDERPGPIQIASQARDSRAREREVGRPGVLQGPPGSPRPPPDRPESLREKSSVIRSLKRPPPADAPPARAARASPDPRAYLPAKELLKPEAEPRPCERALRGPAATAASQQAAKLFGLEPGRPPPPAGPEHKWKPFELGNFATTQMAVLAAQHHHASRAEEEAAAAASKKAYLDPGGALPRAVATCARPGADIHAAAHGPGEASAMQSLIKYSGSFAREAVTVRPGGCGKKSPFGGLGTMKPEPAPTAAPRAQTRLPHPGGPAASSGRQLKRDPERPESAKAFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGGSGRLAPGLADQERSLSLSNVKGHGRADEDCGDDRARHREERLLGARLDRDQEKLLRESKELADLARLHPTSCAANGLNPNLMVTGGPALAGSGRWSADPAAHLATHPWLPRSGSTSMWLAGHPYGLGPPSLHQGMTPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSDHLPHFAELMERAAVPPLWPALYPPGRSSLHHAQQLQLFSQQHFLRQQEFLYLQQQAAQALELQRSAQLVQERLKAQEQRAEMEEKVSKRSLEAAGKAGLGAAGPGLLPRKPPGLSTGPTGTYGKAMSPPPSPRASPVAALKAKVIQKLEDVSKPPAYAYPATPSSHPSSPPPASPPPTPGIARKEEAPENVVEKKDLELEKEAPSPFQALFSDIPARYPFQALPPHYGRPYPFLLQPTAAADADGLAPDVPLPADGPERLALSPEDKPLRLSPSKVPEPLREVPDEEPLVEREVKAEVEDMDEEPAQLPSLESPLTLPPEDALAAPSPAGGLLEAQALSASGQGPEEPPGCPDFAEGAEARVDSPGLTESCAAAPDLGPRLTPEPLVEAKEEPVEVPVDMPVAVPAPLAEVVPGEEDLAQTAPSEPRPSLELPDCDVPAGEGECPRLEAPEAGPVPGGTCFLEEAGSEEFLPSLEDPLAGMNALAAAAELPQARPLPSPGTGAPALETLEAAQSLVLEQSFLHGITLLSEIAELELEKRSQEAAGAERGPPVRPSLESLLAASSHVLKEVLDGPFVDPLKNLRLPRELNPNKKYSWMQKKDERMYAMKSSLESMDAMELDFRMRLAEVQRQYKEKQRELVKLQRRRDSELSGKPLLTSDDYELGAGMRKRHKGPEEDHDALGGAGKARGRNQPWDEHETSSDLMSQLKIKKKKMASDQEQLASKLDKALSLTKQDKLKSPFKFSDGSGGKSKASGGCGRYLTPYDSLLGKDRKALAKGLSLSLKASREGKHKRAAKARKMEVGFKARGQPKSTHSPFASEVSSYSYNTDSEEEEEFLKDEWAAQGPSSSKLTPSLLCGMVAKNSKPAGGPKLTRRGLAGARTLKPKPAAGRKQPFCLLLQEVEPRSSFSDSSEDSFDQDESSEEEDEDDEPEEDEAAGGYRLGARERALSPGLEESGLGLLARFAASALPSPTVGPSLSVVQLEAKQKARKKEERQSLMGTEFEYTDSESEVKVRKRSPAGLLRPKKGLGEPGPALAAPGARTPGPSSPDKAKLAAEKGRKARKSRGPKEPGPEAGPEASDDDLWTRRRSERIFLHDASAPPAPSSAAPTAAKPGRCAKAGLPSPRKDAGRARDRKDPRKKKKGKEAGSGASLPPPRVPALPTEARAPHTSSPASAKRSKAKAKAKEVKKENRGKGGAVSKLMESMAAEEDFEPNQDSSFSEDEHLPRGGAAERPLTPAPRSCIIDKDELKDGLRVLIPMDDKLLYAGHVQTLHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRYLPQGTRIAAYWSQQYRCLYPGTVVRGLLGLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDAGESKDGAAAAPEEPGAKARGRGRKPSTKAKSDRAAVLEEGGSTDDVPSTPLVLEPVSTPGSKKSPPEPVDKRAKTPKARPAPPQPSPAPSTFASCPAPEPFGELPTPAAALAPAPLVTVPITMPATRPKPKKARAAEESASKGARRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREEPKGLLGLGSYAPAAGSPEPKAARPKAADGDLAQEPAVGLAFEDSGTPKSPDKGQAEQDGAEESESGSSSGGSSSDSSSSSSETEGEEDGQGGGGRTCSASSSRASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDDSSCSSDDEAAPAPTAGPSAPPALPSKAPKQAGKARSPGKKAPAPAAQAPPPQPTPPLPPKAQAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRPNLPYIGRIQSMWESWGSNMVVRVKWFYHPEETSPGKRLHEGQPWDQKSGRSLPASLRASSQRKDFMERALYQSSHVDENDVQTVSHKCLVVGLEQYEQMLQTKKHQDSEGLYYLAGTYEPTTGMIFSTDGVPVLC", "length": 2917, "header": "tr|A0A3Q1LN24-1|A0A3Q1M3L3_BOVIN Computationally mapped isoform of Trinucleotide repeat containing 18 OS=Bos taurus OX=9913 GN=TNRC18 PE=4 SV=1 CANONICAL=A0A3Q1M3L3-1" }, "locus": { "chromosome": "25", "start_pos": 38967560, "end_pos": 38887202, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087372.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087372.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058335.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058335.1" } ] } }, { "isoform_ac": "A0A3Q1LQX0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQX0/entry", "sequence": { "sequence": "MALGPEGLALESGEAFLGSFVAGGMGPAASSHGSPVPLPSDLSFRSPTPSNLPMVQLWAAHAHEGFSHLPSGLYPPYLHLSHLEPPSSGSPLLSQLGQPSIFDTQKDGFYLPAPGAPGAPGTLHSHAASSRTPGGHSSGTSTKGASREGPAKERTGRSGEPPPLFGKKDPRAREEAAGPRGVVDLTQEARAEGRQDRGPPRLLERLSPFLAEPGPLRAPGSATAESKGKNPPPPLSLSLCNGTGTGDVGLPALIAEGSRGTKDIARQDESARLRRAEALLPGPCPCPSPLPPPPPPPSKGPPAPSAASGAFAAPQPAPTGVYTIFPAAASREPGREHRVVAPTFVPSVEAFDERPGPIQIASQARDSRAREREVGRPGVLQGPPGSPRPPPDRPESLREKSSVIRSLKRPPPADAPPARAARASPDPRAYLPAKELLKPEAEPRPCERALRGPAATAASQQAAKLFGLEPGRPPPPAGPEHKWKPFELGNFATTQMAVLAAQHHHASRAEEEAAAAASKKAYLDPGGALPRAVATCARPGADIHAAAHGPGEASAMQSLIKYSGSFAREAVTVRPGGCGKKSPFGGLGTMKPEPAPTAAPRAQTRLPHPGGPAASSGRQLKRDPERPESAKAFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGGSGRLAPGLADQERSLSLSNVKGHGRADEDCGDDRARHREERLLGARLDRDQEKLLRESKELADLARLHPTSCAANGLNPNLMVTGGPALAGSGRWSADPAAHLATHPWLPRSGSTSMWLAGHPYGLGPPSLHQGMTPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSDHLPHFAELMERAAVPPLWPALYPPGRSSLHHAQQLQLFSQQHFLRQQEFLYLQQQAAQALELQRSAQLVERLKAQEQRAEMEEKVSKRSLEAAGKAGLGAAGPGLLPRKPPGLSTGPTGTYGKAMSPPPSPRASPVAALKAKVIQKLEDVSKPPAYAYPATPSSHPSSPPPASPPPTPGIARKEEAPENVVEKKDLELEKEAPSPFQALFSDIPARYPFQALPPHYGRPYPFLLQPTAAADADGLAPDVPLPADGPERLALSPEDKPLRLSPSKVPEPLREVPDEEPLVEREVKAEVEDMDEEPAQLPSLESPLTLPPEDALAAPSPAGGLLEAQALSASGQGPEEPPGCPDFAEGAEARVDSPGLTESCAAAPDLGPRLTPEPLVEAKEEPVEVPVDMPVAVPAPLAEVVPGEEDLAQTAPSEPRPSLELPDCDVPAGEGECPRLEAPEAGPVPGGTCFLEEAGSEEFLPSLEDPLAGMNALAAAAELPQARPLPSPGTGAPALETLEAAQSLVLEQSFLHGITLLSEIAELELEKRSQEAAGAERGPPVRPSLESLLAASSHVLKEVLDGPFVDPLKNLRLPRELNPNKKYSWMQKKDERMYAMKSSLESMDAMELDFRMRLAEVQRQYKEKQRELVKLQRRRDSELSGKPLLTSDDYELGAGMRKRHKGPEEDHDALGGAGKARGRNQPWDEHETSSDLMSQLKIKKKKMASDQEQLASKLDKALSLTKQDKLKSPFKFSDGSGGKSKASGGCGRYLTPYDSLLGKDRKALAKGLSLSLKASREGKHKRAAKARKMEVGFKARGQPKSTHSPFASEVSSYSYNTDSEEEEEFLKDEWAAQGPSSSKLTPSLLCGMVAKNSKPAGGPKLTRRGLAGARTLKPKPAAGRKQPFCLLLQEVEPRSSFSDSSEDSFDQDESSEEEDEDDEPEEDEAAGGYRLGARERALSPGLEESGLGLLARFAASALPSPTVGPSLSVVQLEAKQKARKKEERQSLMGTEFEYTDSESEVKVRKRSPAGLLRPKKGLGEPGPALAAPGARTPGPSSPDKAKLAAEKGRKARKSRGPKEPGPEAGPEASDDDLWTRRRSERIFLHDASAPPAPSSAAPTAAKPGRCAKAGLPSPRKDAGRARDRKDPRKKKKGKEAGSGASLPPPRVPALPTEARAPHTSSPASAKRSKAKAKAKEVKKENRGKGGAVSKLMESMAAEEDFEPNQDSSFSEDEHLPRGGAAERPLTPAPRSCIIDKDELKDGLRVLIPMDDKLLYAGHVQTLHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRYLPQGTRIAAYWSQQYRCLYPGTVVRGLLGLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDAGESKDGAAAAPEEPGAKARGRGRKPSTKAKSDRAAVLEEGGSTDDVPSTPLVLEPVSTPGSKKSPPEPVDKRAKTPKARPAPPQPSPAPSTFASCPAPEPFGELPTPAAALAPAPLVTVPITMPATRPKPKKARAAEESASKGARRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREEPKGLLGLGSYAPAAGSPEPKAARPKAADGDLAQEPAVGLAFEDSGTPKSPDKGQAEQDGAEESESGSSSGGSSSDSSSSSSETEGEEDGQGGGGRTCSASSSRASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDDSSCSSDDEAAPAPTAGPSAPPALPSKAPKQAGKARSPGKKAPAPAAQAPPPQPTPPLPPKAQAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRPNLPYIGRIQSMWESWGSNMVVRVKWFYHPEETSPGKRLHEGQPWDQKSGRSLPASLRASSQRKDFMERALYQSSHVDENDVQTVSHKCLVVGLEQYEQMLQTKKHQDSEGLYYLAGTYEPTTGMIFSTDGVPVLC", "length": 2866, "header": "tr|A0A3Q1LQX0-1|A0A3Q1M3L3_BOVIN Computationally mapped isoform of Trinucleotide repeat containing 18 OS=Bos taurus OX=9913 GN=TNRC18 PE=4 SV=2 CANONICAL=A0A3Q1M3L3-1" }, "locus": { "chromosome": "25", "start_pos": 38967560, "end_pos": 38905148, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067509.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067509.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059372.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059372.2" } ] } }, { "isoform_ac": "A0A3Q1LVI3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVI3/entry", "sequence": { "sequence": "MDGRDFGPPRSVHGPPPPLLSGLAMDSHRVGAATAGRLPASGLPGPLPPGKYMAGLNLHPHPGEAFLGSFVAGGMGPAASSHGSPVPLPSDLSFRSPTPSNLPMVQLWAAHAHEDGFYLPAPGAPGAPGTLHSHAASSRTPGGHSSGTSTKGASREGPAKERTGRSGEPPPLFGKKDPRAREEAAGPRGVVDLTQEARAEGRQDRGPPRLLERLSPFLAEPGPLRAPGSATAESKGKNPPPPLSLSLCNGTGTGDVGLPALIAEGSRGTKDIARQDESARLRRAEALLPGPCPCPSPLPPPPPPPSKGPPAPSAASGAFAAPQPAPTGVYTIFPAAASREPGREHRVVAPTFVPSVEAFDERPGPIQIASQARDSRAREREVGRPGVLQGPPGSPRPPPDRPESLREKSSVIRSLKRPPPADAPPARAARASPDPRAYLPAKELLKPEAEPRPCERALRGPAATAASQQAAKLFGLEPGRPPPPAGPEHKWKPFELGNFATTQMAVLAAQHHHASRAEEEAAAAASKKAYLDPGGALPRAVATCARPGADIHAAAHGPGEASAMQSLIKYSGSFAREAVTVRPGGCGKKSPFGGLGTMKPEPAPTAAPRAQTRLPHPGGPAASSGRQLKRDPERPESAKAFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGGSGRLAPGLADQERSLSLSNVKGHGRADEDCGDDRARHREERLLGARLDRDQEKLLRESKELADLARLHPTSCAANGLNPNLMVTGGPALAGSGRWSADPAAHLATHPWLPRSGSTSMWLAGHPYGLGPPSLHQGMTPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSDHLPHFAELMERAAVPPLWPALYPPGRSSLHHAQQLQLFSQQHFLRQQEFLYLQQQAAQALELQRSAQLVQERLKAQEQRAEMEEKVSKRSLEAAGKAGLGAAGPGLLPRKPPGLSTGPTGTYGKAMSPPPSPRASPVAALKAKVIQKLEDVSKPPAYAYPATPSSHPSSPPPASPPPTPGIARKEEAPENVVEKKDLELEKEAPSPFQALFSDIPARYPFQALPPHYGRPYPFLLQPTAAADADGLAPDVPLPADGPERLALSPEDKPLRLSPSKVPEPLREVPDEEPLVEREVKAEVEDMDEEPAQLPSLESPLTLPPEDALAAPSPAGGLLEAQALSASGQGPEEPPGCPDFAEGAEARVDSPGLTESCAAAPDLGPRLTPEPLVEAKEEPVEVPVDMPVAVPAPLAEVVPGEEDLAQTAPSEPRPSLELPDCDVPAGEGECPRLEAPEAGPVPGGTCFLEEAGSEEFLPSLEDPLAGMNALAAAAELPQARPLPSPGTGAPALETLEAAQSLVLEQSFLHGITLLSEIAELELEKRSQEAAGAERGPPVRPSLESLLAASSHVLKEVLDGPFVDPLKNLRLPRELNPNKKYSWMQKKDERMYAMKSSLESMDAMELDFRMRLAEVQRQYKEKQRELVKLQRRRDSELSGKPLLTSDDYELGAGMRKRHKGPEEDHDALGGAGKARGRNQPWDEHETSSDLMSQLKIKKKKMASDQEQLASKLDKALSLTKQDKLKSPFKFSDGSGGKSKASGGCGRYLTPYDSLLGKDRKALAKGLSLSLKASREGKHKRAAKARKMEVGFKARGQPKSTHSPFASEVSSYSYNTDSEEEEEFLKDEWAAQGPSSSKLTPSLLCGMVAKNSKPAGGPKLTRRGLAGARTLKPKPAAGRKQPFCLLLQEVEPRSSFSDSSEDSFDQDESSEEEDEDDEPEEDEAAGGYRLGARERALSPGLEESGLGLLARFAASALPSPTVGPSLSVVQLEAKQKARKKEERQSLMGTEFEYTDSESEVKVRKRSPAGLLRPKKGLGEPGPALAAPGARTPGPSSPDKAKLAAEKGRKARKSRGPKEPGPEAGPEASDDDLWTRRRSERIFLHDASAPPAPSSAAPTAAKPGRCAKAGLPSPRKDAGRARDRKDPRKKKKGKEAGSGASLPPPRVPALPTEARAPHTSSPASAKRSKAKAKAKEVKKENRGKGGAVSKLMESMAAEEDFEPNQDSSFSEDEHLPRGGAAERPLTPAPRSCIIDKDELKDGLRVLIPMDDKLLYAGHVQTLHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRYLPQGTRIAAYWSQQYRCLYPGTVVRGLLGLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDAGESKDGAAAAPEEPGAKARGRGRKPSTKAKSDRAAVLEEGGSTDDVPSTPLVLEPVSTPGSKKSPPEPVDKRAKTPKARPAPPQPSPAPSTFASCPAPEPFGELPTPAAALAPAPLVTVPITMPATRPKPKKARAAEESASKGARRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREEPKGLLGLGSYAPAAGSPEPKAARPKAADGDLAQEPAVGLAFEDSGTPKSPDKGQAEQDGAEESESGSSSGGSSSDSSSSSSETEGEEDGQGGGGRTCSASSSRASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDDSSCSSDDEAAPAPTAGPSAPPALPSKAPKQAGKARSPGKKAPAPAAQAPPPQPTPPLPPKAQAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRPNLPYIGRIQSMWESWGSNMVVRVKWFYHPEETSPGKRLHEGQPWDQKSGRSLPASLRASSQRKDFMERALYQSSHVDENDVQTVSHKCLVVGLEQYEQMLQTKKHQDSEGLYYLAGTYEPTTGMIFSTDGVPVLC", "length": 2875, "header": "tr|A0A3Q1LVI3-1|A0A3Q1M3L3_BOVIN Computationally mapped isoform of Trinucleotide repeat containing 18 OS=Bos taurus OX=9913 GN=TNRC18 PE=4 SV=2 CANONICAL=A0A3Q1M3L3-1" }, "locus": { "chromosome": "25", "start_pos": 38967560, "end_pos": 38887202, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081586.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081586.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061194.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061194.2" } ] } }, { "isoform_ac": "A0A3Q1M3L3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3/entry", "sequence": { "sequence": "MDGRDFGPPRSVHGPPPPLLSGLAMDSHRVGAATAGRLPASGLPGPLPPGKYMAGLNLHPHPGEAFLGSFVAGGMGPAASSHGSPVPLPSDLSFRSPTPSNLPMVQLWAAHAHEGFSHLPSGLYPPYLHLSHLEPPSSGSPLLSQLGQPSIFDTQKDGFYLPAPGAPGAPGTLHSHAASSRTPGGHSSGTSTKGASREGPAKERTGRSGEPPPLFGKKDPRAREEAAGPRGVVDLTQEARAEGRQDRGPPRLLERLSPFLAEPGPLRAPGSATAESKGKNPPPPLSLSLCNGTGTGDVGLPALIAEGSRGTKDIARQDESARLRRAEALLPGPCPCPSPLPPPPPPPSKGPPAPSAASGAFAAPQPAPTGVYTIFPAAASREPGREHRVVAPTFVPSVEAFDERPGPIQIASQARDSRAREREVGRPGVLQGPPGSPRPPPDRPESLREKSSVIRSLKRPPPADAPPARAARASPDPRAYLPAKELLKPEAEPRPCERALRGPAATAASQQAAKLFGLEPGRPPPPAGPEHKWKPFELGNFATTQMAVLAAQHHHASRAEEEAAAAASKKAYLDPGGALPRAVATCARPGADIHAAAHGPGEASAMQSLIKYSGSFAREAVTVRPGGCGKKSPFGGLGTMKPEPAPTAAPRAQTRLPHPGGPAASSGRQLKRDPERPESAKAFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGGSGRLAPGLADQERSLSLSNVKGHGRADEDCGDDRARHREERLLGARLDRDQEKLLRESKELADLARLHPTSCAANGLNPNLMVTGGPALAGSGRWSADPAAHLATHPWLPRSGSTSMWLAGHPYGLGPPSLHQGMTPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSDHLPHFAELMERAAVPPLWPALYPPGRSSLHHAQQLQLFSQQHFLRQQEFLYLQQQAAQALELQRSAQLVQERLKAQEQRAEMEEKVSKRSLEAAGKAGLGAAGPGLLPRKPPGLSTGPTGTYGKAMSPPPSPRASPVAALKAKVIQKLEDVSKPPAYAYPATPSSHPSSPPPASPPPTPGIARKEEAPENVVEKKDLELEKEAPSPFQALFSDIPARYPFQALPPHYGRPYPFLLQPTAAADADGLAPDVPLPADGPERLALSPEDKPLRLSPSKVPEPLREVPDEEPLVEREVKAEVEDMDEEPAQLPSLESPLTLPPEDALAAPSPAGGLLEAQALSASGQGPEEPPGCPDFAEGAEARVDSPGLTESCAAAPDLGPRLTPEPLVEAKEEPVEVPVDMPVAVPAPLAEVVPGEEDLAQTAPSEPRPSLELPDCDVPAGEGECPRLEAPEAGPVPGGTCFLEEAGSEEFLPSLEDPLAGMNALAAAAELPQARPLPSPGTGAPALETLEAAQSLVLEQSFLHGITLLSEIAELELEKRSQEAAGAERGPPVRPSLESLLAASSHVLKEVLDGPFVDPLKNLRLPRELNPNKKYSWMQKKDERMYAMKSSLESMDAMELDFRMRLAEVQRQYKEKQRELVKLQRRRDSEDRREEPHRSLARRGPGRPRKRTHALSALSPPRKRGKSRIHSGKLSGKPLLTSDDYELGAGMRKRHKGPEEDHDALGGAGKARGRNQPWDEHETSSDLMSQLKIKKKKMASDQEQLASKLDKALSLTKQDKLKSPFKFSDGSGGKSKASGGCGRYLTPYDSLLGKDRKALAKGLSLSLKASREGKHKRAAKARKMEVGFKARGQPKSTHSPFASEVSSYSYNTDSEEEEEFLKDEWAAQGPSSSKLTPSLLCGMVAKNSKPAGGPKLTRRGLAGARTLKPKPAAGRKQPFCLLLQEVEPRSSFSDSSEDSFDQDESSEEEDEDDEPEEDEAAGGYRLGARERALSPGLEESGLGLLARFAASALPSPTVGPSLSVVQLEAKQKARKKEERQSLMGTEFEYTDSESEVKVRKRSPAGLLRPKKGLGEPGPALAAPGARTPGPSSPDKAKLAAEKGRKARKSRGPKEPGPEAGPEASDDDLWTRRRSERIFLHDASAPPAPSSAAPTAAKPGRCAKAGLPSPRKDAGRARDRKDPRKKKKGKEAGSGASLPPPRVPALPTEARAPHTSSPASAKRSKAKAKAKEVKKENRGKGGAVSKLMESMAAEEDFEPNQDSSFSEDEHLPRGGAAERPLTPAPRSCIIDKDELKDGLRVLIPMDDKLLYAGHVQTLHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRYLPQGTRIAAYWSQQYRCLYPGTVVRGLLGLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDAGESKDGAAAAPEEPGAKARGRGRKPSTKAKSDRAAVLEEGGSTDDVPSTPLVLEPVSTPGSKKSPPEPVDKRAKTPKARPAPPQPSPAPSTFASCPAPEPFGELPTPAAALAPAPLVTVPITMPATRPKPKKARAAEESASKGARRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREEPKGLLGLGSYAPAAGSPEPKAARPKAADGDLAQEPAVGLAFEDSGTPKSPDKGQAEQDGAEESESGSSSGGSSSDSSSSSSETEGEEDGQGGGGRTCSASSSRASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDDSSCSSDDEAAPAPTAGPSAPPALPSKAPKQAGKARSPGKKAPAPAAQAPPPQPTPPLPPKAQAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRPNLPYIGRIQSMWESWGSNMVVRVKWFYHPEETSPGKRLHEGQPWDQKSGRSLPASLRASSQRKDFMERALYQSSHVDENDVQTVSHKCLVVGLEQYEQMLQTKKHQDSEGLYYLAGTYEPTTGMIFSTDGVPVLC", "length": 2960, "header": "tr|A0A3Q1M3L3-1|A0A3Q1M3L3_BOVIN Isoform 1 of Trinucleotide repeat containing 18 OS=Bos taurus OX=9913 GN=TNRC18 PE=4 SV=1 CANONICAL=A0A3Q1M3L3-1" }, "locus": { "chromosome": "25", "start_pos": 38967560, "end_pos": 38887202, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082733.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082733.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062782.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062782.1" } ] } }, { "isoform_ac": "A0A3Q1MMX6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMX6/entry", "sequence": { "sequence": "MRLSRLSTPRLRSHRQGERSNSSGLGPEASFPSLVLLEILGRSRSSLGEAFLGSFVAGGMGPAASSHGSPVPLPSDLSFRSPTPSNLPMVQLWAAHAHEGFSHLPSGLYPPYLHLSHLEPPSSGSPLLSQLGQPSIFDTQKDGFYLPAPGAPGAPGTLHSHAASSRTPGGHSSGTSTKGASREGPAKERTGRSGEPPPLFGKKDPRAREEAAGPRGVVDLTQEARAEGRQDRGPPRLLERLSPFLAEPGPLRAPGSATAESKGKNPPPPLSLSLCNGTGTGDVGLPALIAEGSRGTKDIARQDESARLRRAEALLPGPCPCPSPLPPPPPPPSKGPPAPSAASGAFAAPQPAPTGVYTIFPAAASREPGREHRVVAPTFVPSVEAFDERPGPIQIASQARDSRAREREVGRPGVLQGPPGSPRPPPDRPESLREKSSVIRSLKRPPPADAPPARAARASPDPRAYLPAKELLKPEAEPRPCERALRGPAATAASQQAAKLFGLEPGRPPPPAGPEHKWKPFELGNFATTQMAVLAAQHHHASRAEEEAAAAASKKAYLDPGGALPRAVATCARPGADIHAAAHGPGEASAMQSLIKYSGSFAREAVTVRPGGCGKKSPFGGLGTMKPEPAPTAAPRAQTRLPHPGGPAASSGRQLKRDPERPESAKAFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGGSGRLAPGLADQERSLSLSNVKGHGRADEDCGDDRARHREERLLGARLDRDQEKLLRESKELADLARLHPTSCAANGLNPNLMVTGGPALAGSGRWSADPAAHLATHPWLPRSGSTSMWLAGHPYGLGPPSLHQGMTPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSDHLPHFAELMERAAVPPLWPALYPPGRSSLHHAQQLQLFSQQHFLRQQEFLYLQQQAAQALELQRSAQLVQERLKAQEQRAEMEEKVSKRSLEAAGKAGLGAAGPGLLPRKPPGLSTGPTGTYGKAMSPPPSPRASPVAALKAKVIQKLEDVSKPPAYAYPATPSSHPSSPPPASPPPTPGIARKEEAPENVVEKKDLELEKEAPSPFQALFSDIPARYPFQALPPHYGRPYPFLLQPTAAADADGLAPDVPLPADGPERLALSPEDKPLRLSPSKVPEPLREVPDEEPLVEREVKAEVEDMDEEPAQLPSLESPLTLPPEDALAAPSPAGGLLEAQALSASGQGPEEPPGCPDFAEGAEARVDSPGLTESCAAAPDLGPRLTPEPLVEAKEEPVEVPVDMPVAVPAPLAEVVPGEEDLAQTAPSEPRPSLELPDCDVPAGEGECPRLEAPEAGPVPGGTCFLEEAGSEEFLPSLEDPLAGMNALAAAAELPQARPLPSPGTGAPALETLEAAQSLVLEQSFLHGITLLSEIAELELEKRSQEAAGAERGPPVRPSLESLLAASSHVLKEVLDGPFVDPLKNLRLPRELNPNKKYSWMQKKDERMYAMKSSLESMDAMELDFRMRLAEVQRQYKEKQRELVKLQRRRDSELSGKPLLTSDDYELGAGMRKRHKGPEEDHDALGGAGKARGRNQPWDEHETSSDLMSQLKIKKKKMASDQEQLASKLDKALSLTKQDKLKSPFKFSDGSGGKSKASGGCGRYLTPYDSLLGKDRKALAKGLSLSLKASREGKHKRAAKARKMEVGFKARGQPKSTHSPFASEVSSYSYNTDSEEEEEFLKDEWAAQGPSSSKLTPSLLCGMVAKNSKPAGGPKLTRRGLAGARTLKPKPAAGRKQPFCLLLQEVEPRSSFSDSSEDSFDQDESSEEEDEDDEPEEDEAAGGYRLGARERALSPGLEESGLGLLARFAASALPSPTVGPSLSVVQLEAKQKARKKEERQSLMGTEFEYTDSESEVKVRKRSPAGLLRPKKGLGEPGPALAAPGARTPGPSSPDKAKLAAEKGRKARKSRGPKEPGPEAGPEASDDDLWTRRRSERIFLHDASAPPAPSSAAPTAAKPGRCAKAGLPSPRKDAGRARDRKDPRKKKKGKEAGSGASLPPPRVPALPTEARAPHTSSPASAKRSKAKAKAKEVKKENRGKGGAVSKLMESMAAEEDFEPNQDSSFSEDEHLPRGGAAERPLTPAPRSCIIDKDELKDGLRVLIPMDDKLLYAGHVQTLHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRYLPQGTRIAAYWSQQYRCLYPGTVVRGLLGLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDAGESKDGAAAAPEEPGAKARGRGRKPSTKAKSDRAAVLEEGGSTDDVPSTPLVLEPVSTPGSKKSPPEPVDKRAKTPKARPAPPQPSPAPSTFASCPAPEPFGELPTPAAALAPAPLVTVPITMPATRPKPKKARAAEESASKGARRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREEPKGLLGLGSYAPAAGSPEPKAARPKAADGDLAQEPAVGLAFEDSGTPKSPDKGQAEQDGAEESESGSSSGGSSSDSSSSSSETEGEEDGQGGGGRTCSASSSRASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDDSSCSSDDEAAPAPTAGPSAPPALPSKAPKQAGKARSPGKKAPAPAAQAPPPQPTPPLPPKAQAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRPNLPYIGRIQSMWESWGSNMVVRVKWFYHPEETSPGKRLHEGQPWDQKSGRSLPASLRASSQRKDFMERALYQSSHVDENDVQTVSHKCLVVGLEQYEQMLQTKKHQDSEGLYYLAGTYEPTTGMIFSTDGVPVLC", "length": 2902, "header": "tr|A0A3Q1MMX6-1|A0A3Q1M3L3_BOVIN Computationally mapped isoform of Trinucleotide repeat containing 18 OS=Bos taurus OX=9913 GN=TNRC18 PE=4 SV=2 CANONICAL=A0A3Q1M3L3-1" }, "locus": { "chromosome": "25", "start_pos": 38967560, "end_pos": 38879127, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082441.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082441.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073204.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073204.2" } ] } }, { "isoform_ac": "E1BLK1-1", "url": "https://www.uniprot.org/uniprotkb/E1BLK1/entry", "sequence": { "sequence": "MDGRDFGPPRSVHGPPPPLLSGLAMDSHRVGAATAGRLPASGLPGPLPPGKYMAGLNLHPHPGFSHLPSGLYPPYLHLSHLEPPSSGSPLLSQLGQPSIFDTQKDGFYLPAPGAPGAPGTLHSHAASSRTPGGHSSGTSTKGASREGPAKERTGRSGEPPPLFGKKDPRAREEAAGPRGVVDLTQEARAEGRQDRGPPRLLERLSPFLAEPGPLRAPGSATAESKGKNPPPPLSLSLCNGTGTGDVGLPALIAEGSRGTKDIARQDESARLRRAEALLPGPCPCPSPLPPPPPPPSKGPPAPSAASGAFAAPQPAPTGVYTIFPAAASREPGREHRVVAPTFVPSVEAFDERPGPIQIASQARDSRAREREVGRPGVLQGPPGSPRPPPDRPESLREKSSVIRSLKRPPPADAPPARAARASPDPRAYLPAKELLKPEAEPRPCERALRGPAATAASQQAAKLFGLEPGRPPPPAGPEHKWKPFELGNFATTQMAVLAAQHHHASRAEEEAAAAASKKAYLDPGGALPRAVATCARPGADIHAAAHGPGEASAMQSLIKYSGSFAREAVTVRPGGCGKKSPFGGLGTMKPEPAPTAAPRAQTRLPHPGGPAASSGRQLKRDPERPESAKAFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGGSGRLAPGLADQERSLSLSNVKGHGRADEDCGDDRARHREERLLGARLDRDQEKLLRESKELADLARLHPTSCAANGLNPNLMVTGGPALAGSGRWSADPAAHLATHPWLPRSGSTSMWLAGHPYGLGPPSLHQGMTPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSDHLPHFAELMERAAVPPLWPALYPPGRSSLHHAQQLQLFSQQHFLRQQEFLYLQQQAAQALELQRSAQLVQERLKAQEQRAEMEEKVSKRSLEAAGKAGLGAAGPGLLPRKPPGLSTGPTGTYGKAMSPPPSPRASPVAALKAKVIQKLEDVSKPPAYAYPATPSSHPSSPPPASPPPTPGIARKEEAPENVVEKKDLELEKEAPSPFQALFSDIPARYPFQALPPHYGRPYPFLLQPTAAADADGLAPDVPLPADGPERLALSPEDKPLRLSPSKVPEPLREVPDEEPLVEREVKAEVEDMDEEPAQLPSLESPLTLPPEDALAAPSPAGGLLEAQALSASGQGPEEPPGCPDFAEGAEARVDSPGLTESCAAAPDLGPRLTPEPLVEAKEEPVEVPVDMPVAVPAPLAEVVPGEEDLAQTAPSEPRPSLELPDCDVPAGEGECPRLEAPEAGPVPGGTCFLEEAGSEEFLPSLEDPLAGMNALAAAAELPQARPLPSPGTGAPALETLEAAQSLVLEQSFLHGITLLSEIAELELEKRSQEAAGAERGPPVRPSLESLLAASSHVLKEVLDGPFVDPLKNLRLPRELNPNKKYSWMQKKDERMYAMKSSLESMDAMELDFRMRLAEVQRQYKEKQRELVKLQRRRDSEDRREEPHRSLARRGPGRPRKRTHALSALSPPRKRGKSRIHSGKLSGKPLLTSDDYELGAGMRKRHKGPEEDHDALGGAGKARGRNQPWDEHETSSDLMSQLKIKKKKMASDQEQLASKLDKALSLTKQDKLKSPFKFSDGSGGKSKASGGCGRYLTPYDSLLGKDRKALAKGLSLSLKASREGKHKRAAKARKMEVGFKARGQPKSTHSPFASEVSSYSYNTDSEEEEEFLKDEWAAQGPSSSKLTPSLLCGMVAKNSKPAGGPKLTRRGLAGARTLKPKPAAGRKQPFCLLLQEVEPRSSFSDSSEDSFDQDESSEEEDEDDEPEEDEAAGGYRLGARERALSPGLEESGLGLLARFAASALPSPTVGPSLSVVQLEAKQKARKKEERQSLMGTEFEYTDSESEVKVRKRSPAGLLRPKKGLGEPGPALAAPGARTPGPSSPDKAKLAAEKGRKARKSRGPKEPGPEAGPEASDDDLWTRRRSERIFLHDASAPPAPSSAAPTAAKPGRCAKAGLPSPRKDAGRARDRKDPRKKKKGKEAGSGASLPPPRVPALPTEARAPHTSSPASAKRSKAKAKAKEVKKENRGKGGAVSKLMESMAAEEDFEPNQDSSFSEDEHLPRGGAAERPLTPAPRSCIIDKDELKDGLRVLIPMDDKLLYAGHVQTLHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRYLPQGTRIAAYWSQQYRCLYPGTVVRGLLGLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDAGESKDGAAAAPEEPGAKARGRGRKPSTKAKSDRAAVLEEGGSTDDVPSTPLVLEPVSTPGSKKSPPEPVDKRAKTPKARPAPPQPSPAPSTFASCPAPEPFGELPTPAAALAPAPLVTVPITMPATRPKPKKARAAEESASKGARRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREEPKGLLGLGSYAPAAGSPEPKAARPKAADGDLAQEPAVGLAFEDSGTPKSPDKGQAEQDGAEESESGSSSGGSSSDSSSSSSETEGEEDGQGGGGRTCSASSSRASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDDSSCSSDDEAAPAPTAGPSAPPALPSKAPKQAGKARSPGKKAPAPAAQAPPPQPTPPLPPKAQAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRPNLPYIGRIQSMWESWGSNMVVRVKWFYHPEETSPGKRLHEGQPWDQKSGRSLPASLRASSQRKDFMERALYQSSHVDENDVQTVSHKCLVVGLEQYEQMLQTKKHQDSEGLYYLAGTYEPTTGMIFSTDGVPVLC", "length": 2908, "header": "tr|E1BLK1-1|A0A3Q1M3L3_BOVIN Computationally mapped isoform of Trinucleotide repeat containing 18 OS=Bos taurus OX=9913 GN=TNRC18 PE=4 SV=3 CANONICAL=A0A3Q1M3L3-1" }, "locus": { "chromosome": "25", "start_pos": 38967560, "end_pos": 38887202, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028865.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028865.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028865.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028865.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1045, "start_aa": "Thr", "end_pos": 1045, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1045", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1061, "start_aa": "Thr", "end_pos": 1061, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1061", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1899, "start_aa": "Thr", "end_pos": 1899, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1899", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2036, "start_aa": "Thr", "end_pos": 2036, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2036", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2434, "start_aa": "Thr", "end_pos": 2434, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2434", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2686, "start_aa": "Thr", "end_pos": 2686, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2686", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2726, "start_aa": "Thr", "end_pos": 2726, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2726", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 647, "start_aa": "Thr", "end_pos": 647, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr647", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:526616", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526616", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AKW0-1", "protein_name": "Trinucleotide repeat-containing gene 18 protein", "gene_name": "Tnrc18", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDGRDFGPQRSVHGPPPPLLSGLAMDSHRVGAATAGRLPSSGLPGPPPPGKYMAGLNLHPHPGEAFLGSFVASGMGPSASSQGSPVSLPSDLSFRSPTPSNLPMVHLWAAHAHEGFSHLPSGLYPSYLHLNHLEPPSSGSPLLSQLGQPSIFDTQKDGFYLPAPGTLHAHTPSSRTPSGHSSGGTAKGSSREGTGKDRSSRGGDPPPLFGKKDPRAREEVSGPRGVVDLTQEVRAEGRQDRGSSRLAERLSPFLAEAKAKGALQPSALSLCNGVVDAGLVAELSRGGAKEVARQEENARLLRRAEALLPAARPCGSPLPPPPPPLPPKGPPAPPSSTPAGVYTVFREPGREHRVVAPTFVPSVEAFDERVGPIQIASQARDVRAREREPGRPGVLQGPPGSPRLERPEVLREKSSVIRSLKRPPPSDGPPAARSSRSSPDARAYLPPKELLKPEADPRPCERAPRGPSSSAAQQAAKLFGLEPSRPPGPEHKWKPFELGNFATTQMAVLAAQHHHASRAEEEAAVATASKKAYLDPGGAMPRASATCGRPGADLHSAAAHGPGEASAMQSLIKYSGSFAREAVAVRPGGCGKKSPFGGLGTMKPEPIPTSAGPPRAQARLTHPGVPTAGGGRQLKRDPERPESAKTFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGSSSRLGPGLIDQERSLSLNNVKGHGRTEDDCDRARHREDRLLGTRLDRDQEKLLRESKELADLARLHPTSCAPNGLNPNLMVTGGPTLAGSGRWSADPAAHLATHPWLPRSGSTSMWLAGHPYGLGPPSLHQGMAPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSDHLPHFAELMERATVPPLWPALYPPGRSPLHHAQQLQLFSQQHFLRQQELLYLQQQAAQALELQRSAQLVQERLKAQEHRTEMEEKITKRGLETTGKAGLSATGPGLLPQKSAGLATGPTGTHGKAMSPPPSPRASPVTSLKAKVIQKVEDVSKPPAYTYPATPSSHPSSPPPASPPPTPGLTRKEEAPENVVEKKDLELEKEAPSPFQALFTDIPPRYPFQALPPHYGRPYPFLLQPTAAADADGLAPDVPLPADGPERLALSPEDKPICLSPSKIPEPPRDSQEEERLADREVKAEIEDIEEGPTELPRLESPLALPVPETMVAVSPAGGCGGSPLEAQALSTAGPGCREPSEVSDFAQVAEPQIELPSRTEPHMAALELGTQLTPEPLVEAKEEPVEVPLDVPMEEPVAETGPEDSLPQPPLTEPPPSLELSDCDLPVPEGQCLNLEAQEAAPAPASTYLEETHPESLLPGLDDPLAGMNALAAAAELPQARPLPSLGTGVPGGEKLDTAPSLVLEHSFLQGITLLSEIAELELDRRGQEVPGPEPNLVVRPSLESLLAASSHMLKEVLESPLSDSLKNLRLPRELNSNKKYSWMQKKEERMFAMKSSLEDMDALELDFRMRLAEVQRRYKEKQRELVKLQRRRDSGDRHEDAHRSLTRRGPGRPRKRTHTPSALSPPCKRGKSHSGSGKLSSKSLLTSDDYDLGAGIRKRHKGPEEEQEALVSMGKARSRNQSWDDHESSSDFMSQLKIKKKKMSSDQEQLASKLDRALSLTKQDKLKSPFKFSDSPGGKWKTSGGCGRFLTQCDSLLGKDRKALAKGLGLSLKPSREGKHKRASKARKMEGGFKARGQPKSVHSPFASEVSSHSYNTDSDEDEDLLKNSWSAQGPSSSKLTSSLLGMVAKNSKPATGPKLTKRGPSGPRTLKPKEATSRKQSFCLLLREAEAHSSFSDSSAEDSFDQDDSSEEEEEELEEEEEDEEEEGIGSYRLGAGEQALSPSLEESGLGLLARFAASALPSPVVGPPLSVVQLEAEQKARKKEERQSLMGTEFEYTDSESEVKVPKQSPAGLLRPKKGAGEPGQSLAAPVPGTRASGPTSPDKAKLASEKGRKARKIRGSKEPGFEAGPEASDDDLWTRRRSERIFLHDASAAVQAPSNAAPATKPSRCGRGGAPSPRKDTGRAKDRKDPRKKKRGKEAGSAATLPSPRVSTLPDSRAPHPGALATAKRSKAKARGKEAKKENRGKGGAVSKLMECMAAEEDFEPNQDSSFSEDEHLPRGGATERPLTPAPRSCIIDKEELKDGLRVLIPMDDKLLYAGHVQTVHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRFLPQGTRIAAYWSQQYRCLYPGTVVRGLLDLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDTGEGKEGAATGPQEATGGKARGRGRKPSTKAKADRAVVLEEGAATNELPSAPLALEPVSTPNSKKSTPEPVDKRARAPKARSVSVQPSPGPPTFSSCPAPEPFGELPTPATAPLVTMPVTMPATRPKPKKARATEGSGAKGPRRPGEDDELLVKLDHEGVMSPKSKKAKEALLLREDPGPGAWPESTGLLSLGSYSPTVGSSEPKATWPKGLDGDLTQEPGPGLPLEDPGNSKSPDKAQAEQDGAEESETTSSSSSSSSSSSSSSSSSSSSSSSSSGSETEGEEDAEKNREDGRGAGGRTCSAASSRASSPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPAAGPSTQPALPTKVSKPPSKARASAHSPGKKAPPTTQPPPQPPPQPQQTLQPKTQTGAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRPNLPYIGRIQSMWESWGNNMVVRVKWFYHPEETSPGKQFHEGQHWDQKSGHNLPAALRASSQRKDFMERALYQSSHVDENDVQTVSHKCLVVGLEQYEQMLKTKKYQDSEGLYYLAGTYEPTTGMIFSTDGVPVLC", "length": 2952 }, "evidence": [ { "id": "A0A3Q1M3L3", "url": "https://omabrowser.org/oma/group/A0A3Q1M3L3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O15417-1", "protein_name": "Trinucleotide repeat-containing gene 18 protein", "gene_name": "TNRC18", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDGRDFGPQRSVHGPPPPLLSGLAMDSHRVGAATAGRLPASGLPGPLPPGKYMAGLNLHPHPGEAFLGSFVASGMGPSASSHGSPVPLPSDLSFRSPTPSNLPMVQLWAAHAHEGFSHLPSGLYPSYLHLNHLEPPSSGSPLLSQLGQPSIFDTQKGQGPGGDGFYLPTAGAPGSLHSHAPSARTPGGGHSSGAPAKGSSSRDGPAKERAGRGGEPPPLFGKKDPRARGEEASGPRGVVDLTQEARAEGRQDRGPPRLAERLSPFLAESKTKNAALQPSVLTMCNGGAGDVGLPALVAEAGRGGAKEAARQDEGARLLRRTETLLPGPRPCPSPLPPPPAPPKGPPAPPAATPAGVYTVFREQGREHRVVAPTFVPSVEAFDERPGPIQIASQARDARAREREAGRPGVLQAPPGSPRPLDRPEGLREKNSVIRSLKRPPPADAPTVRATRASPDPRAYVPAKELLKPEADPRPCERAPRGPAGPAAQQAAKLFGLEPGRPPPTGPEHKWKPFELGNFAATQMAVLAAQHHHSRAEEEAAVVAASSSKKAYLDPGAVLPRSAATCGRPVADMHSAAHGSGEASAMQSLIKYSGSFARDAVAVRPGGCGKKSPFGGLGTMKPEPAPTSAGASRAQARLPHSGGPAAGGGRQLKRDPERPESAKAFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGGSGRLGPGLVDQERSLSLSNVKGHGRADEDCVDDRARHREERLLGARLDRDQEKLLRESKELADLARLHPTSCAPNGLNPNLMVTGGPALAGSGRWSADPAAHLATHPWLPRSGNASMWLAGHPYGLGPPSLHQGMAPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSDHLPHFAELMERATVPPLWPALYPPGRSPLHHAQQLQLFSQQHFLRQQEFLYLQQQAAQALELQRSAQLVQERLKAQEHRAEMEEKGSKRGLEAAGKAGLATAGPGLLPRKPPGLAAGPAGTYGKAVSPPPSPRASPVAALKAKVIQKLEDVSKPPAYAYPATPSSHPTSPPPASPPPTPGITRKEEAPENVVEKKDLELEKEAPSPFQALFSDIPPRYPFQALPPHYGRPYPFLLQPTAAADADGLAPDVPLPADGPERLALSPEDKPIRLSPSKITEPLREGPEEEPLAEREVKAEVEDMDEGPTELPPLESPLPLPAAEAMATPSPAGGCGGGLLEAQALSATGQSCAEPSECPDFVEGPEPRVDSPGRTEPCTAALDLGVQLTPETLVEAKEEPVEVPVAVPVVEAVPEEGLAQVAPSESQPTLEMSDCDVPAGEGQCPSLEPQEAVPVLGSTCFLEEASSDQFLPSLEDPLAGMNALAAAAELPQARPLPSPGAAGAQALEKLEAAESLVLEQSFLHGITLLSEIAELELERRSQEMGGAERALVARPSLESLLAAGSHMLREVLDGPVVDPLKNLRLPRELKPNKKYSWMRKKEERMYAMKSSLEDMDALELDFRMRLAEVQRQYKEKQRELVKLQRRRDSEDRREEPHRSLARRGPGRPRKRTHAPSALSPPRKRGKSGHSSGKLSSKSLLTSDDYELGAGIRKRHKGSEEEHDALIGMGKARGRNQTWDEHEASSDFISQLKIKKKKMASDQEQLASKLDKALSLTKQDKLKSPFKFSDSAGGKSKTSGGCGRYLTPYDSLLGKNRKALAKGLGLSLKSSREGKHKRAAKTRKMEVGFKARGQPKSAHSPFASEVSSYSYNTDSEEDEEFLKDEWPAQGPSSSKLTPSLLCSMVAKNSKAAGGPKLTKRGLAAPRTLKPKPATSRKQPFCLLLREAEARSSFSDSSEESFDQDESSEEEDEEEELEEEDEASGGGYRLGARERALSPGLEESGLGLLARFAASALPSPTVGPSLSVVQLEAKQKARKKEERQSLLGTEFEYTDSESEVKVRKRSPAGLLRPKKGLGEPGPSLAAPTPGARGPDPSSPDKAKLAVEKGRKARKLRGPKEPGFEAGPEASDDDLWTRRRSERIFLHDASAAAPAPVSTAPATKTSRCAKGGPLSPRKDAGRAKDRKDPRKKKKGKEAGPGAGLPPPRAPALPSEARAPHASSLTAAKRSKAKAKGKEVKKENRGKGGAVSKLMESMAAEEDFEPNQDSSFSEDEHLPRGGAVERPLTPAPRSCIIDKDELKDGLRVLIPMDDKLLYAGHVQTVHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRFLPQGTRIAAYWSQQYRCLYPGTVVRGLLDLEDDGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDTGEGKDGGTAGSEEPGAKARGRGRKPSAKAKGDRAATLEEGNPTDEVPSTPLALEPSSTPGSKKSPPEPVDKRAKAPKARPAPPQPSPAPPAFTSCPAPEPFAELPAPATSLAPAPLITMPATRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPLQPKAQAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRPNLPYIGRIQSMWESWGNNMVVRVKWFYHPEETSPGKQFHQGQHWDQKSSRSLPAALRVSSQRKDFMERALYQSSHVDENDVQTVSHKCLVVGLEQYEQMLKTKKYQDSEGLYYLAGTYEPTTGMIFSTDGVPVLC", "length": 2968 }, "evidence": [ { "id": "A0A3Q1M3L3", "url": "https://omabrowser.org/oma/group/A0A3Q1M3L3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "X1WHA2-1", "protein_name": "Trinucleotide repeat-containing gene 18 protein isoform X1", "gene_name": "tnrc18", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMDGRDFGPPRSVHVPPPILSGLPMESHRLGAAAAAGRIPPSPGHLGAGHPAALHTGKYLSSAMNLHSHHSDAFPGASSPFLGGYVGASSAHGSSDPAFRAPNQASLQMAQLWASHSHEGFSHLPSSLYPSPYIPLGHLEHPQLSQHALFDSQKEGFYLPGSVHSQSAMARSPVAHMPGSFSRERESLPPHKSSKESSRDVGKEKPCKSDLAHSLPRKEREKPKEESRPHSVVDLTLDLKAEDERRVGNLERPAKTTEHARPFFHQHSPALSNTDTKPKQTNHSLLGNSGTSSGTPTRHQSTEQDRRDRDDETIRPGGHLSNDKQKRCDSVATSAGTLHVSYASPSSLQPSPSHLPPRLVSSGTYPPPHHMPPSMYPLYSTTKEPGKEHRVIAPTYVPSVEVYDERKGPIQIASQARDNKNDKSRERESHRSALQLGNERTLMDHGRSSVRSESPPHGDVKRDILREEGSIIRSNGLAMKKPLHLEMCTNKSGNSPDARDLTNTTSKHMIRTGLETESRSQERDRVQRSTHSFSGMDPSSLHTEQHPLKTLGSAEPKWKPFEMGNYATSHMAALAAQHNHGARGEEEGKQMYLDTTSLHRPVGSSGSPDGHGEVSAMQSLIKYSGNFSSESGSRHGSDSRSPFGGLGSLKLEAGYPGVSRVQHLPPQQPGKQLKKEPERPESAKSFGRDGSSSQGEAEVRHPPVGIAVAVARQRDNSSKSSSASDRDRPLLGGPIKGPIHTEEEQGDERPRHRDERLLSGRVEREQEKVLRENKELADYTQLHPPMVSASGLNPNLMVTGGPTLAGAGRWPADPASHLASHPWLSRPGAPSMWLSGSPYGLGPPSLHQALPPGYPPALTGSIPPPYQFARDPQTGQVVVIPTEHLPHYAEMLERGPPLWSAMYPPAGSSLQHAHQLQLLSHQQLLRQHELYMIQHQTAQVMELQRNAQLVERLNASQPRTDLDEKLDKRAAEVHKSSLSCIPTTTLHSRKPPPCSPTPSTSYSKALTPLPVPPLPSPVTALKSEERPKVEKSLPQQPYSHPSSPAPHSISPASASPSPTSSIRTKEESVEVSEKEPLSLQKQPSTTFPSIYREIPPGYPYQSITAPFGSHYPYLLQPAAAADADGLAPDVPLPAETSEHLAIAADVKPQHLCSPVLVEPLQTSREPEPMEEEGSTVFKKEPNLEDLKDDSIRLAPIITQDSSTPTDPEAHPRTIATPSPEEDPEQEHGEDIKIKRTSLYETSRLDVERSASTETTDASTGLVDYKSSSSYSDTHLVVCDVQPTKQPLDLSDSLNPADLRDAVPDSSTHLESKLDNLFLPNSGPPHLPPSSAAVAILPEDPMAGMFALVTASELPQAGAMSILTDACSSRSELCTDVSPLESTALEGMALLSQMAELEMQRQPRDDTQAVIFCGLESLLEAGRQVLLEAIECEPQVIIRLPRELNPNKKYSWRQKKDEPMFSKSSLEGMDAAEVDYRVRLAELQQRYKEKQRELVKLQRRRDKEEKRQQQQQHIQQQERNRSLARRGPGRPRKRKHGLCALSPPSSKLDSRCAKLSRSVLYSEDSESGEVLRKRFRASNRDEEEEEEDGSSALKLKKKKKSWGEQEACSSFSHEVPKMAVKKSRVSEQEQLASKLDKALSLTKLNKFSKPSCKFIDGSSGKSRPSSGSRVPMLTDLDVRVKMGKSSLSKDLGIFQKTSKGGKSKTAAKTKPSEACLKGKGQRKAPYSPVRSEISSYSNNTDSEEEDSLKDGWPSSSMLGRTGSHPQLPGLCSTPSKKKRSSSKRASSSSSSSLKSKQAAKERKHKHFALLLQEAGVSSSEDSFDQEYSTERDDSEDDDEDEDGYDYELDESDGLCSSSVEESGLGLLARFAASAIPSPIITNPLSLVQLEAKQKAKKKEERQSLLGTEFEFTDSESDVKTRKKFPSLLHGKRSAPELPLLPPASVMRDDSSPTKRGRKPKKPKSPREFSFDLTADGSEDEQWTRRRSERIFLHDAAQSTPISPSSKTPLPLTPKPARGPKTSPQSPKELVKAKEVKDPSKKKRIKETPLCLPPPQLSSTPSETSGALPVSPGRKNKVQKPKAREELGQNVLEFPQQARGKGGAVSKLMESMAADEDFEPNQDSSFSEDENPSVSAQPERPCTPAPRNCVINKDELQDGLRVLIPMDDKLLYAGHVSTVHSPDIYSVVVEGERGNRPHIYCLEQLLQEAIIDVKPPSVRYLPQGTRIAAYWSQQYRCLYPGTVVRGSPDMEDVDDLITVEFDDGDTGRIPLSHIRLLPADYKIQCAEPSPALLVASTKRRGRKCSKDVPDGKETPPKITEESAPKSKGRGRKPKPKPEPEAAPKEHEKPDTPTPTQVPERPLSSQKSSPRPGRKIKQVGTASVSIPASNENQKKTTGIKPPAKVRSQPQSVYSQPLYGKVLSVDLYNEPSTSLASFISNNETSSPTGKGKTVKRLRKPEEEASGFGVKTQRKQPQTEILIKLDHEGVMSPKTKKTKALMMMEGQNLSKRENKSVMGVSYTTISTTEKTIKAKSKPVEAEPPTAESVSTYSVRKLGSSSEGLMKVSNSGKKEKKDLECSSSSSSSSSESDGEEEQGATQEKKPKQDSASSISSRASSPTSSSSSTSSSSSGSHSSSSSSSSSTTSDEESSCSSDEEPVADSQPSPAAEHVASPEEEDVKAKSGSAPNIHKLQKQSSTTQQRHQQKTPQRQQKVKQGVGRPKRREGIHLPTTKELAKRQRLPSVENRPKISAFLPARQLWKWFGKPTQRRGMKGKAKKLFYKAIMRGKEMIRIGDCAVFLSAGRPNLPFIGHIQSMWESWGNNMVVRVKWFYHPEETNPGKKLHDKKNWDQMSGQSLPAVLQASNQRKDFMERALYQSSHIDENDVQTISHKCLVVSLEQYEQMIKTKKYQDSEDLYYLAGTYEPTTGMIFNTDGVPVIC", "length": 2936 }, "evidence": [ { "id": "A0A3Q1M3L3", "url": "https://omabrowser.org/oma/group/A0A3Q1M3L3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3L3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3" } ], "pmid": "" }, { "name": "histone H3K9me2/3 reader activity", "id": "GO:0062072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062072", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3L3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3L3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3L3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3L3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3L3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3L3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein localization to chromatin", "id": "GO:0071168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071168", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3L3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3" } ], "pmid": "" }, { "name": "transposable element silencing by heterochromatin formation", "id": "GO:0141005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141005", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3L3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M3L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L3" }, { "id": "PS51038", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51038" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BAH", "eco_id": "ECO_0000259", "start_pos": 2809, "end_pos": 2954, "start_aa": "Glu", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 647, 1045, 1061, 1899, 2036, 2434, 2686, 2726 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 291, "end_pos": 293 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 8 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 8 }, { "field": "exact_o_linked_sites", "count": 8 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 8 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 8 }, { "field": "exact_o_linked_sites", "count": 8 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M2Z8-1", "uniprot_ac": "A0A3Q1M2Z8", "uniprot_id": "A0A3Q1M2Z8_BOVIN", "mass": { "chemical_mass": 139128.0, "monoisotopic_mass": 139128.0 }, "refseq": { "ac": "XP_059734822", "name": "ras-associated and pleckstrin homology domains-containing protein 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734822" }, "gene_names": [ { "name": "RAPH1", "type": "recommended", "evidence": [ { "id": "A0A3Q1M2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Z8" } ] }, { "name": "RAPH1", "type": "synonym", "evidence": [ { "id": "XP_059734822", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734822" } ] } ], "protein_names": [ { "name": "Ras association (RalGDS/AF-6) and pleckstrin homology domains 1", "type": "synonym", "evidence": [ { "id": "A0A3Q1M2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Z8/entry#names_and_taxonomy" } ] }, { "name": "ras-associated and pleckstrin homology domains-containing protein 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059734822", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734822" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2Z8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Z8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAPH1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Z8", "locus": { "chromosome": "2", "start_pos": 91615615, "end_pos": 91708237, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027201", "url": "https://www.ensembl.org/id/ENSBTAG00000027201" } ] } } ], "crossref": [ { "id": "ENSBTAG00000027201", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027201", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01259", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01259", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16136", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16136", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523153", "url": "https://www.ncbi.nlm.nih.gov/gene/523153", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039664", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039664", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039665", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039665", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523153", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523153", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BPM7", "url": "https://www.orthodb.org/?gene=E1BPM7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11243", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11243", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11243:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11243:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21989", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21989", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059734822", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734822", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LND5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LND5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LND5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LND5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2Z8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Z8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2Z8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Z8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0R3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0R3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0R3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPM7", "url": "https://www.uniprot.org/uniprotkb/E1BPM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPM7-1", "url": "https://www.uniprot.org/uniprotkb/E1BPM7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPTEPIKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGAGNTKRQITETKATQKLPTSRHTSKHGTLKGLSSSSNRITKPSHANYSLDDITAQLEQASLSMDEAAQQSVLEDTKPLVTNQHRRTASAGTVSDAEVRSISNSSRSSITSATSSMDSLDIDKVARPQELDLTHQGQPITEHAISLRCPSKQAKRHIDFTEEQAELTPEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETISELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDMRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSMVSSIFSEAWKRGTQLEESSKARMESVNRPYTSLIPPLSPQPKLVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAATMFVKYSTITRLQNASQHSGALFKPPPASGMQPSTSLSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCTPSLPQFSPPPPPLKIHHIQHGTQTAPPAPPPPPPVPAPLPPQAPPKPLVTLPPAASTKTVPPAVTQSLPPTPTPPVPPVKKQPVLPVSHVPPSPPVPPGPVPPPTLPKQQSFSVKPPPSPLSPAPSVVKQIASQFPPPPAPPPAEGPPLKPASVSLTPQSPPAVKAKPKWQPSSVPVPSPDFPPPPPESSLVFPPPPPPPPAPAPQPPPPPPPPATPAAAPAPDKSSSPGRKTSKTCSPGAKKPPPTPQRNSSIKSSSCAEHPEPKKPSVDSLISKFASPAEPSGSPSKETPPPPAAPPKPGKLHLSGVNLPGVLQQGCLPVKAAALSGRGKDSAVEFPSPPSDSDFPPPPPETELPLPPIDIPAVFSGSTSPKVAVVNPQPQPWSKTSVKKAPPPTRPKRNDSTRLTQAEISEQPATAAVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSSRVSRAEPTATMDDMALPPPPPELLSEQQKAAYGGSHISGYATLRRGPPPAPPKRDQNTKLSRDW", "length": 1289, "header": "tr|A0A3Q1M2Z8-1|A0A3Q1M2Z8_BOVIN Isoform 1 of Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 OS=Bos taurus OX=9913 GN=RAPH1 PE=3 SV=1 CANONICAL=A0A3Q1M2Z8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LND5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LND5/entry", "sequence": { "sequence": "MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPTEPIKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGAGNTKRQITETKATQKLPTSRHTSKHGTLKGLSSSSNRITKPSHANYSLDDITAQLEQASLSMDEAAQQSVLEDTKPLVTNQHRRTASAGTVSDAEVRSISNSSRSSITSATSSMDSLDIDKVARPQELDLTHQGQPITEEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETISELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDMRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSMVSSIFSEAWKRGTQLEESSKVNY", "length": 595, "header": "tr|A0A3Q1LND5-1|A0A3Q1M2Z8_BOVIN Computationally mapped isoform of Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 OS=Bos taurus OX=9913 GN=RAPH1 PE=3 SV=2 CANONICAL=A0A3Q1M2Z8-1" }, "locus": { "chromosome": "2", "start_pos": 91708184, "end_pos": 91615615, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086599.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086599.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061495.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061495.2" } ] } }, { "isoform_ac": "A0A3Q1M2Z8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Z8/entry", "sequence": { "sequence": "MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPTEPIKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGAGNTKRQITETKATQKLPTSRHTSKHGTLKGLSSSSNRITKPSHANYSLDDITAQLEQASLSMDEAAQQSVLEDTKPLVTNQHRRTASAGTVSDAEVRSISNSSRSSITSATSSMDSLDIDKVARPQELDLTHQGQPITEHAISLRCPSKQAKRHIDFTEEQAELTPEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETISELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDMRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSMVSSIFSEAWKRGTQLEESSKARMESVNRPYTSLIPPLSPQPKLVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAATMFVKYSTITRLQNASQHSGALFKPPPASGMQPSTSLSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCTPSLPQFSPPPPPLKIHHIQHGTQTAPPAPPPPPPVPAPLPPQAPPKPLVTLPPAASTKTVPPAVTQSLPPTPTPPVPPVKKQPVLPVSHVPPSPPVPPGPVPPPTLPKQQSFSVKPPPSPLSPAPSVVKQIASQFPPPPAPPPAEGPPLKPASVSLTPQSPPAVKAKPKWQPSSVPVPSPDFPPPPPESSLVFPPPPPPPPAPAPQPPPPPPPPATPAAAPAPDKSSSPGRKTSKTCSPGAKKPPPTPQRNSSIKSSSCAEHPEPKKPSVDSLISKFASPAEPSGSPSKETPPPPAAPPKPGKLHLSGVNLPGVLQQGCLPVKAAALSGRGKDSAVEFPSPPSDSDFPPPPPETELPLPPIDIPAVFSGSTSPKVAVVNPQPQPWSKTSVKKAPPPTRPKRNDSTRLTQAEISEQPATAAVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSSRVSRAEPTATMDDMALPPPPPELLSEQQKAAYGGSHISGYATLRRGPPPAPPKRDQNTKLSRDW", "length": 1289, "header": "tr|A0A3Q1M2Z8-1|A0A3Q1M2Z8_BOVIN Isoform 1 of Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 OS=Bos taurus OX=9913 GN=RAPH1 PE=3 SV=1 CANONICAL=A0A3Q1M2Z8-1" }, "locus": { "chromosome": "2", "start_pos": 91708184, "end_pos": 91652751, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077642.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077642.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062502.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062502.1" } ] } }, { "isoform_ac": "A0AAA9T0R3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0R3/entry", "sequence": { "sequence": "MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPTEPIKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGAGNTKRQITETKATQKLPTSRHTSKHGTLKGLSSSSNRITKPSHANYSLDDITAQLEQASLSMDEAAQQSVLEDTKPLVTNQHRRTASAGTVSDAEVRSISNSSRSSITSATSSMDSLDIDKVARPQELDLTHQGQPITEHSYLDRETSLLLRNIAGKPSHLLTKEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETISELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDMRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSMVSSIFSEAWKRGTQLEESSK", "length": 617, "header": "tr|A0AAA9T0R3-1|A0A3Q1M2Z8_BOVIN Computationally mapped isoform of Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 OS=Bos taurus OX=9913 GN=RAPH1 PE=3 SV=1 CANONICAL=A0A3Q1M2Z8-1" }, "locus": { "chromosome": "2", "start_pos": 91708184, "end_pos": 91657352, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100207.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100207.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089973.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089973.1" } ] } }, { "isoform_ac": "E1BPM7-1", "url": "https://www.uniprot.org/uniprotkb/E1BPM7/entry", "sequence": { "sequence": "MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPTEPIKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGAGNTKRQITETKATQKLPTSRHTSKHGTLKGLSSSSNRITKPSHANYSLDDITAQLEQASLSMDEAAQQSVLEDTKPLVTNQHRRTASAGTVSDAEVRSISNSSRSSITSATSSMDSLDIDKVARPQELDLTHQGQPITEEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETISELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDMRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSMVSSIFSEAWKRGTQLEESSKARMESVNRPYTSLIPPLSPQPKLVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAATMFVKYSTITRLQNASQHSGALFKPPPASGMQPSTSLSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCTPSLPQFSPPPPPLKIHHIQHGTQTAPPAPPPPPPVPAPLPPQAPPKPLVTLPPAASTKTVPPAVTQSLPPTPTPPVPPVKKQPVLPVSHVPPSPPVPPGPVPPPTLPKQQSFSVKPPPSPLSPAPSVVKQIASQFPPPPAPPPAEGPPLKPASVSLTPQSPPAVKAKPKWQPSSVPVPSPDFPPPPPESSLVFPPPPPPPPAPAPQPPPPPPPPATPAAAPAPDKSSSPGRKTSKTCSPGAKKPPPTPQRNSSIKSSSCAEHPEPKKPSVDSLISKFASPAEPSGSPSKETPPPPAAPPKPGKLHLSGVNLPGVLQQGCLPVKAAALSGRGKDSAVEFPSPPSDSDFPPPPPETELPLPPIDIPAVFSGSTSPKVAVVNPQPQPWSKTSVKKAPPPTRPKRNDSTRLTQAEISEQPATAAVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSSRVSRAEPTATMDDMALPPPPPELLSEQQKAAYGGSHISGYATLRRGPPPAPPKRDQNTKLSRDW", 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"https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026966", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026966", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LP71", "url": "https://www.orthodb.org/?gene=A0A3Q1LP71", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3L7", "url": "https://www.orthodb.org/?gene=A0A3Q1M3L7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBI4", "url": "https://www.orthodb.org/?gene=A0A3Q1MBI4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N110", "url": "https://www.orthodb.org/?gene=A0A3Q1N110", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BLM2", "url": "https://www.orthodb.org/?gene=E1BLM2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12231", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12231", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12231:SF257", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12231:SF257", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13882", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13882", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LP71", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LP71-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP71-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3L7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3L7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBI4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBI4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N110", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N110", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N110-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N110-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N5A4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5A4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N5A4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5A4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLM2", "url": "https://www.uniprot.org/uniprotkb/E1BLM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BLM2-1", "url": "https://www.uniprot.org/uniprotkb/E1BLM2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQLKIMPKKKRLSAGRAPLMLFLCQMISALEVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPSPSFSWTRNGTHFDIDKDPLVTMKPGSGTLTINIMSEGKAETYEGVYQCTARNERGAAISNNIVIRPSRSPLWTKEKLEPIILRNGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSHRPRPPTFLTPDGNTSRKEELRGNVLSLECIAEGLPTPIIYWIKEDGTLPINRTFYRNFKKTLQIVQVTEADSGNYQCIAKNALGAIHHTISVTVKAAPYWIIAPQNLVLSPEEDGTLICRANGNPKPRISWLSNGVPIEIAPDDPSRKIDGDTIIFSKVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTSANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALREDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNDVHLEIKDPTRIIKQPEYAVVQRGSTVSFECKVKHDHTLIPTVMWLKDHGELPNDGRFTVDKDRLVVADVNDDDGGTYTCVANTTLDNVSASAVLSVVDVPNPPFDLELTDQLDRSVQLSWTPGDDNNSPITKFIIEYEDAMHEPGLWHHQTEVPGTQTTAQLKLSPYVNYSFRVMAENNLGRSLPSEASEQYLTKAAEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDAGFAPEPAAVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKAQSSLTRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDKVFNTPEGVPSAPSSLKIVNPTLDSLTLEWEPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWILKNLNFSTRYKFYFYAQTAAGSGIQITEEAITTVDEAGILPPDVGAGKAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV", "length": 1195, "header": "tr|A0A3Q1M3L7-1|A0A3Q1M3L7_BOVIN Isoform 1 of Neuronal cell adhesion molecule OS=Bos taurus OX=9913 GN=NRCAM PE=3 SV=2 CANONICAL=A0A3Q1M3L7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LP71-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP71/entry", "sequence": { "sequence": "MQLKIMPKKKRLSAGRAPLMLFLCQMISALEVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPSPSFSWTRNGTHFDIDKDPLVTMKPGSGTLTINIMSEGKAETYEGVYQCTARNERGAAISNNIVIRPSRSPLWTKEKLEPIILRNGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSHRPRPPTFLTPDGNTSRKEELRGNVLSLECIAEGLPTPIIYWIKEDGTLPINRTFYRNFKKTLQIVQVTEADSGNYQCIAKNALGAIHHTISVTVKAAPYWIIAPQNLVLSPEEDGTLICRANGNPKPRISWLSNGVPIEIAPDDPSRKIDGDTIIFSKVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTSANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALREDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNDVHLEIKDPTRIIKQPEYAVVQRGSTVSFECKVKHDHTLIPTVMWLKDHGELPNDGRFTVDKDRLVVADVNDDDGGTYTCVANTTLDNVSASAVLSVVDVPNPPFDLELTDQLDRSVQLSWTPGDDNNSPITKFIIEYEDAMHEPGLWHHQTEVPGTQTTAQLKLSPYVNYSFRVMAENNLGRSLPSEASEQYLTKAAEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDAGFAPEPAAVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKAQSSLTRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDKVFNTPEGVPSAPSSLKIVNPTLDSLTLEWEPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWILKNLNFSTRYKFYFYAQTAAGSGIQITEEAITTVDEGKLAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV", "length": 1186, "header": "tr|A0A3Q1LP71-1|A0A3Q1M3L7_BOVIN Computationally mapped isoform of Neuronal cell adhesion molecule OS=Bos taurus OX=9913 GN=NRCAM PE=3 SV=2 CANONICAL=A0A3Q1M3L7-1" }, "locus": { "chromosome": "4", "start_pos": 49338452, "end_pos": 49248705, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073623.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073623.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058702.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058702.2" } ] } }, { "isoform_ac": "A0A3Q1M3L7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L7/entry", "sequence": { "sequence": "MQLKIMPKKKRLSAGRAPLMLFLCQMISALEVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPSPSFSWTRNGTHFDIDKDPLVTMKPGSGTLTINIMSEGKAETYEGVYQCTARNERGAAISNNIVIRPSRSPLWTKEKLEPIILRNGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSHRPRPPTFLTPDGNTSRKEELRGNVLSLECIAEGLPTPIIYWIKEDGTLPINRTFYRNFKKTLQIVQVTEADSGNYQCIAKNALGAIHHTISVTVKAAPYWIIAPQNLVLSPEEDGTLICRANGNPKPRISWLSNGVPIEIAPDDPSRKIDGDTIIFSKVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTSANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALREDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNDVHLEIKDPTRIIKQPEYAVVQRGSTVSFECKVKHDHTLIPTVMWLKDHGELPNDGRFTVDKDRLVVADVNDDDGGTYTCVANTTLDNVSASAVLSVVDVPNPPFDLELTDQLDRSVQLSWTPGDDNNSPITKFIIEYEDAMHEPGLWHHQTEVPGTQTTAQLKLSPYVNYSFRVMAENNLGRSLPSEASEQYLTKAAEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDAGFAPEPAAVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKAQSSLTRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDKVFNTPEGVPSAPSSLKIVNPTLDSLTLEWEPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWILKNLNFSTRYKFYFYAQTAAGSGIQITEEAITTVDEAGILPPDVGAGKAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV", "length": 1195, "header": "tr|A0A3Q1M3L7-1|A0A3Q1M3L7_BOVIN Isoform 1 of Neuronal cell adhesion molecule OS=Bos taurus OX=9913 GN=NRCAM PE=3 SV=2 CANONICAL=A0A3Q1M3L7-1" }, "locus": { "chromosome": "4", "start_pos": 49338452, "end_pos": 49248705, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080861.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080861.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068113.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068113.2" } ] } }, { "isoform_ac": "A0A3Q1MBI4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBI4/entry", "sequence": { "sequence": "MQLKIMPKKKRLSAGRAPLMLFLCQMISALEVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPSPSFSWTRNGTHFDIDKDPLVTMKPGSGTLTINIMSEGKAETYEGVYQCTARNERGAAISNNIVIRPSRSPLWTKEKLEPIILRNGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISAKSHRPRPPTFLTPDGNTSRKEELRGNVLSLECIAEGLPTPIIYWIKEDGTLPINRTFYRNFKKTLQIVQVTEADSGNYQCIAKNALGAIHHTISVTVKAAPYWIIAPQNLVLSPEEDGTLICRANGNPKPRISWLSNGVPIEIAPDDPSRKIDGDTIIFSKVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTSANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALREDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNDVHLEIKDPTRIIKQPEYAVVQRGSTVSFECKVKHDHTLIPTVMWLKDHGELPNDGRFTVDKDRLVVADVNDDDGGTYTCVANTTLDNVSASAVLSVVDVPNPPFDLELTDQLDRSVQLSWTPGDDNNSPITKFIIEYEDAMHEPGLWHHQTEVPGTQTTAQLKLSPYVNYSFRVMAENNLGRSLPSEASEQYLTKAAEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDAGFAPEPAAVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKAQSSLTRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDKVFNTPEGVPSAPSSLKIVNPTLDSLTLEWEPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWILKNLNFSTRYKFYFYAQTAAGSGIQITEEAITTVDEAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV", "length": 1164, "header": "tr|A0A3Q1MBI4-1|A0A3Q1M3L7_BOVIN Computationally mapped isoform of Neuronal cell adhesion molecule OS=Bos taurus OX=9913 GN=NRCAM PE=3 SV=2 CANONICAL=A0A3Q1M3L7-1" }, "locus": { "chromosome": "4", "start_pos": 49338452, "end_pos": 49248705, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066362.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066362.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068074.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068074.2" } ] } }, { "isoform_ac": "A0A3Q1N110-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N110/entry", "sequence": { "sequence": "MQLKIMPKKKRLSAGRAPLMLFLCQMISALEVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPSPSFSWTRNGTHFDIDKDPLVTMKPGSGTLTINIMSEGKAETYEGVYQCTARNERGAAISNNIVIRPSRSPLWTKEKLEPIILRNGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISAKSHRPRPPTFLTPDGNTSRKEELRGNVLSLECIAEGLPTPIIYWIKEDGTLPINRTFYRNFKKTLQIVQVTEADSGNYQCIAKNALGAIHHTISVTVKAAPYWIIAPQNLVLSPEEDGTLICRANGNPKPRISWLSNGVPIEIAPDDPSRKIDGDTIIFSKVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTSANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALREDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNDVHLEIKDPTRIIKQPEYAVVQRGSTVSFECKVKHDHTLIPTVMWLKDHGELPNDGRFTVDKDRLVVADVNDDDGGTYTCVANTTLDNVSASAVLSVVAPTPTPAPIYDVPNPPFDLELTDQLDRSVQLSWTPGDDNNSPITKFIIEYEDAMHEPGLWHHQTEVPGTQTTAQLKLSPYVNYSFRVMAENNLGRSLPSEASEQYLTKAAEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDAGFAPEPAAVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKAQSSLTRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDKVFNTPEGVPSAPSSLKIVNPTLDSLTLEWEPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWILKNLNFSTRYKFYFYAQTAAGSGIQITEEAITTVDEAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV", "length": 1174, "header": "tr|A0A3Q1N110-1|A0A3Q1M3L7_BOVIN Computationally mapped isoform of Neuronal cell adhesion molecule OS=Bos taurus OX=9913 GN=NRCAM PE=3 SV=2 CANONICAL=A0A3Q1M3L7-1" }, "locus": { "chromosome": "4", "start_pos": 49338452, "end_pos": 49248705, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068765.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068765.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062561.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062561.2" } ] } }, { "isoform_ac": "A0A3Q1N5A4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5A4/entry", "sequence": { "sequence": "MQLKIMPKKKRLSAGRAPLMLFLCQMISALEVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPSPSFSWTRNGTHFDIDKDPLVTMKPGSGTLTINIMSEGKAETYEGVYQCTARNERGAAISNNIVIRPSRSPLWTKEKLEPIILRNGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSHRPRPPTFLTPDGNTSRKEELRGNVLSLECIAEGLPTPIIYWIKEDGTLPINRTFYRNFKKTLQIVQVTEADSGNYQCIAKNALGAIHHTISVTVKAAPYWIIAPQNLVLSPEEDGTLICRANGNPKPRISWLSNGVPIEIAPDDPSRKIDGDTIIFSKVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTSANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALREDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNDVHLEIKDPTRIIKQPEYAVVQRGSTVSFECKVKHDHTLIPTVMWLKDHGELPNDGRFTVDKDRLVVADVNDDDGGTYTCVANTTLDNVSASAVLSVVDVPNPPFDLELTDQLDRSVQLSWTPGDDNNSPITKFIIEYEDAMHEPGLWHHQTEVPGTQTTAQLKLSPYVNYSFRVMAENNLGRSLPSEASEQYLTKAAEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDAGFAPEPAAVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKAQSSLTRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDKVFNTPEGVPSAPSSLKIVNPTLDSLTLEWEPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWILKNLNFSTRYKFYFYAQTAAGSGIQITEEAITTVDEGKLAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYRSLESDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV", "length": 1190, "header": "tr|A0A3Q1N5A4-1|A0A3Q1M3L7_BOVIN Computationally mapped isoform of Neuronal cell adhesion molecule OS=Bos taurus OX=9913 GN=NRCAM PE=3 SV=1 CANONICAL=A0A3Q1M3L7-1" }, "locus": { "chromosome": "4", "start_pos": 49338452, "end_pos": 49248705, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077914.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077914.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065309.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065309.2" } ] } }, { "isoform_ac": "E1BLM2-1", "url": "https://www.uniprot.org/uniprotkb/E1BLM2/entry", "sequence": { "sequence": "MQLKIMPKKKRLSAGRAPLMLFLCQMISALEVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPSPSFSWTRNGTHFDIDKDPLVTMKPGSGTLTINIMSEGKAETYEGVYQCTARNERGAAISNNIVIRPSRSPLWTKEKLEPIILRNGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSHRPRPPTFLTPDGNTSRKEELRGNVLSLECIAEGLPTPIIYWIKEDGTLPINRTFYRNFKKTLQIVQVTEADSGNYQCIAKNALGAIHHTISVTVKAAPYWIIAPQNLVLSPEEDGTLICRANGNPKPRISWLSNGVPIEIAPDDPSRKIDGDTIIFSKVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTSANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALREDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNDVHLEIKDPTRIIKQPEYAVVQRGSTVSFECKVKHDHTLIPTVMWLKDHGELPNDGRFTVDKDRLVVADVNDDDGGTYTCVANTTLDNVSASAVLSVVDVPNPPFDLELTDQLDRSVQLSWTPGDDNNSPITKFIIEYEDAMHEPGLWHHQTEVPGTQTTAQLKLSPYVNYSFRVMAENNLGRSLPSEASEQYLTKAAEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDAGFAPEPAAVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKAQSSLTRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDKVFNTPEGVPSAPSSLKIVNPTLDSLTLEWEPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWILKNLNFSTRYKFYFYAQTAAGSGIQITEEAITTVDEAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV", 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} }, { "isoform_ac": "A0A3Q1M4E1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4E1/entry", "sequence": { "sequence": "MGGSSPPLVPHPDGQARALARTHAQLWRTRAGPRREKMAAPSFPTPLHGHVGRGDFSDVYEPAEDTFLLLDALEAAAAELTGVEICLEVGSGSGVVSAFLASVIGPQALYMCTDVNPEAAACTLETARCNKVHIQPIITDLVKGLLPRLKESVDLLVFNPPYVVTPPEEVGSRGIQAAWAGGRNGREVIDRFLPLAPDLLSPRGLFYLVTIKENNPEEILKIMKTKGLQGTTVLSRQAGQEMLSVLKFTKKCNLYIPVRA", "length": 260, "header": "tr|A0A3Q1M4E1-1|A0A3Q1M4E1_BOVIN Isoform 1 of Methyltransferase HEMK2 OS=Bos taurus OX=9913 GN=N6AMT1 PE=3 SV=2 CANONICAL=A0A3Q1M4E1-1" }, "locus": { "chromosome": "1", "start_pos": 7280943, "end_pos": 7260248, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074692.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074692.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064672.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064672.2" } ] } }, { "isoform_ac": "F6R0T8-1", "url": "https://www.uniprot.org/uniprotkb/F6R0T8/entry", "sequence": { "sequence": "MGGSSPPLVPHPDGQARALARTHAQLWRTRAGPRREKMAAPSFPTPLHGHVGRGDFSDVYEPAEDTFLLLDALEAAAAELTGVEICLEVGSGSGVVSAFLASVIGPQALYMCTDVNPEAAACTLETARCNKVHIQPIITDLVKGLLPRLKESVDLLVFNPPYVVTPPEEVGSRGIQAAWAGGRNGREVIDRFLPLAPDLLSPRGLFYLVTIKENNPEEILKIMKTKGLQGTTVLSRQAGQEMLSVLKFTKS", "length": 251, "header": "tr|F6R0T8-1|A0A3Q1M4E1_BOVIN Computationally mapped isoform of Methyltransferase HEMK2 OS=Bos taurus OX=9913 GN=N6AMT1 PE=3 SV=2 CANONICAL=A0A3Q1M4E1-1" }, "locus": { "chromosome": "1", "start_pos": 7280943, "end_pos": 7267906, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001851.6", "url": "https://www.ensembl.org/id/ENSBTAT00000001851.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001851.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001851.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 165, "start_aa": "Thr", "end_pos": 165, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr165", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-156581", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156581", "resource": "Reactome", "description": "Methylation" }, { "id": "R-BTA-72764", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72764", "resource": "Reactome", "description": "Eukaryotic Translation Termination" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4E1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4E1" } ], "pmid": "" }, { "name": "eRF1 methyltransferase complex", "id": "GO:0035657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035657", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4E1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4E1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4E1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4E1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein-glutamine N-methyltransferase activity", "id": "GO:0036009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036009", "evidence": [ { "database": 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"id": "10024", "name": "", "equation": "L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "10024", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10024" } ] }, { "id": "11684", "name": "", "equation": "methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "11684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11684" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M4E1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 260, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, 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{ "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"annotation": "Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LTB5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTB5#function" }, { "database": "UniProtKB", "id": "RU060637", "url": "https://www.uniprot.org/uniprotkb/RU060637#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3R3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3", "locus": {} } ], "crossref": [ { "id": "A0A3Q1M3R3", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M3R3", "database": "AlphaFoldDB", "categories": [] }, { "id": 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Classification" ] }, { "id": "A0A3Q1M3R3", "url": "https://www.orthodb.org/?gene=A0A3Q1M3R3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00822", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00822", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LTB5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTB5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3R3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3R3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASLGLQLVGYVLGLLGLLGTVIAMLLPSWRTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTMLGLPADIQAAQAMMVTSSAMSSLACIVSVVGMRCTVFFQESRAKDRVAVVGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAGIFLCFSCSPQGNRSNYYDAYQAQPLATRSSPRPGQAPKGKSEFNSYSLTGFLTQDPFVLTARRRGNSVLSCHKEAKYIIIL", "length": 259, "header": "tr|A0A3Q1M3R3-1|A0A3Q1M3R3_BOVIN Isoform 1 of Claudin 2 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0A3Q1M3R3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTB5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTB5/entry", "sequence": { "sequence": "MASLGLQLVGYVLGLLGLLGTVIAMLLPSWRTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTMLGLPADIQAAQAMMVTSSAMSSLACIVSVVGMRCTVFFQESRAKDRVAVVGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAGIFLCFSCSPQGNRSNYYDAYQAQPLATRSSPRPGQAPKGKSEFNSYSLTGPKLLKILPQSLN", "length": 240, "header": "tr|A0A3Q1LTB5-1|A0A3Q1M3R3_BOVIN Computationally mapped isoform of Claudin 2 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0A3Q1M3R3-1" }, "locus": { "chromosome": "X", "start_pos": 55483885, "end_pos": 55475490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076290.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076290.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058360.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058360.2" } ] } }, { "isoform_ac": "A0A3Q1M3R3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3/entry", "sequence": { "sequence": "MASLGLQLVGYVLGLLGLLGTVIAMLLPSWRTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTMLGLPADIQAAQAMMVTSSAMSSLACIVSVVGMRCTVFFQESRAKDRVAVVGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAGIFLCFSCSPQGNRSNYYDAYQAQPLATRSSPRPGQAPKGKSEFNSYSLTGFLTQDPFVLTARRRGNSVLSCHKEAKYIIIL", "length": 259, "header": "tr|A0A3Q1M3R3-1|A0A3Q1M3R3_BOVIN Isoform 1 of Claudin 2 OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0A3Q1M3R3-1" }, "locus": { "chromosome": "X", "start_pos": 55493033, "end_pos": 55475490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076420.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076420.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064816.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064816.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LD71-1", "protein_name": "Claudin", "gene_name": "Cldn2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASLGVQLVGYILGLLGLLGTSIAMLLPNWRTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAMSSLACIISVVGMRCTVFCQESRAKDRVAVVGGVFFILGGILGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISALFSLVAGVILCFSCSPQGNRTNYYDGYQAQPLATRSSPRSAQQPKAKSEFNSYSLTGNGSTATGRQ", "length": 237 }, "evidence": [ { "id": "A0A3Q1M3R3", "url": "https://omabrowser.org/oma/group/A0A3Q1M3R3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1C8Q0-1", "protein_name": "Claudin", "gene_name": "CLDN2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVSMGLQLVGYIVAFLGYIGTLTTTLLPNWKISSYIGSSIVTAVSFTKGLWMECATYSTGITQCDIYSSLLNLPPDIQAAQALMVSSCAVSSLACLIAVVGMRCTVFNQGSPAKDRVAVAGGVVFILGGLLCFIPLVWNIHVVLRDFHNPLLPDSTKFEMGEALYLGIISSLLTLIGGFILCASCPPRDPSGPYSPRLLASRSPQPSIKQMQKPKSEFSSYNLTGYV", "length": 227 }, "evidence": [ { "id": "A0A3Q1M3R3", "url": "https://omabrowser.org/oma/group/A0A3Q1M3R3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3I169-1", "protein_name": "Claudin", "gene_name": "Cldn2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASLGVQLVGYILGLLGLLGTSIAMLLPNWRTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAMSSLACIISVVGMRCTVFCQESRAKDRVAVVGGVFFILGGILGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLVAGVILCFSCSPRGNRTNYYDGYQAQPLATRSSPRPGQQLKAKSEFNSYSLTGYV", "length": 230 }, "evidence": [ { "id": "A0A3Q1M3R3", "url": "https://omabrowser.org/oma/group/A0A3Q1M3R3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O88552-1", "protein_name": "Claudin-2", "gene_name": "Cldn2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASLGVQLVGYILGLLGLLGTSIAMLLPNWRTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAMSSLACIISVVGMRCTVFCQDSRAKDRVAVVGGVFFILGGILGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISALFSLVAGVILCFSCSPQGNRTNYYDGYQAQPLATRSSPRSAQQPKAKSEFNSYSLTGYV", "length": 230 }, "evidence": [ { "id": "A0A3Q1M3R3", "url": "https://omabrowser.org/oma/group/A0A3Q1M3R3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P57739-1", "protein_name": "Claudin-2", "gene_name": "CLDN2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASLGLQLVGYILGLLGLLGTLVAMLLPSWKTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIISVVGMRCTVFCQESRAKDRVAVAGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAGIILCFSCSSQRNRSNYYDAYQAQPLATRSSPRPGQPPKVKSEFNSYSLTGYV", "length": 230 }, "evidence": [ { "id": "A0A3Q1M3R3", "url": "https://omabrowser.org/oma/group/A0A3Q1M3R3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3R3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3R3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3R3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3" } ], "pmid": "" }, { "name": "paracellular tight junction channel activity", "id": "GO:0160187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160187", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3R3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3R3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules", "id": "GO:0016338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016338", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3R3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3" } ], "pmid": "" }, { "name": "paracellular transport", "id": "GO:0160184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160184", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3R3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3" } ], "pmid": "" }, { "name": "regulation of intestinal lipid absorption", "id": "GO:1904729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904729", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3R3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3" } ], "pmid": "" }, { "name": "innate immune response in mucosa", "id": "GO:0002227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002227", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3R3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3" } ], "pmid": "" }, { "name": "regulation of bile acid secretion", "id": "GO:0120188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120188", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3R3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3" } ], "pmid": "" }, { "name": "regulation of intestinal D-glucose absorption", "id": "GO:1903985", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903985", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3R3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3R3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M3R3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 259, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": 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"InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050274", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050274", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505531", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505531", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IHWARSI", "url": "https://omabrowser.org/oma/group/IHWARSI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LTR5", "url": "https://www.orthodb.org/?gene=A0A3Q1LTR5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZU3", "url": "https://www.orthodb.org/?gene=A0A3Q1LZU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B9Y6", "url": "https://www.orthodb.org/?gene=E1B9Y6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24083", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24083", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00104", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00104", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00105", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00105", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-383280", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9940951", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9940951", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010816274", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010816274", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTR5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTR5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTR5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZU3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZU3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZU3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Y6", "url": "https://www.uniprot.org/uniprotkb/E1B9Y6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9Y6-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Y6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVAEKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDCKAETSQGALGTLANVVTSLANLSGPLNNGDTAETQPEDQSASEITRAFDTLAKALNTTDSASPPSLADGIDGSGGGGIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMARLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSSITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL", "length": 596, "header": "tr|A0A3Q1LZU3-1|A0A3Q1LZU3_BOVIN Isoform 1 of Nuclear receptor subfamily 2 group C member 2 OS=Bos taurus OX=9913 GN=NR2C2 PE=3 SV=2 CANONICAL=A0A3Q1LZU3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTR5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTR5/entry", "sequence": { "sequence": "MKVKSESEVAQSCPTLATPWTAVYQAPPSMGFSRQEYWSGVPLPSPNGTLVNSVPRTQTSRPESPGMTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVAEKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDCKAETSQGALGTLANVVTSLANLSGPLNNGDTAETQPEDQSASEITRAFDTLAKALNTTDSASPPSLADGIDGSGGGGIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMARLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSSITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL", "length": 662, "header": "tr|A0A3Q1LTR5-1|A0A3Q1LZU3_BOVIN Computationally mapped isoform of Nuclear receptor subfamily 2 group C member 2 OS=Bos taurus OX=9913 GN=NR2C2 PE=3 SV=2 CANONICAL=A0A3Q1LZU3-1" }, "locus": { "chromosome": "22", "start_pos": 57366686, "end_pos": 57260572, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069938.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069938.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058536.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058536.2" } ] } }, { "isoform_ac": "A0A3Q1LZU3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZU3/entry", "sequence": { "sequence": "MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVAEKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDCKAETSQGALGTLANVVTSLANLSGPLNNGDTAETQPEDQSASEITRAFDTLAKALNTTDSASPPSLADGIDGSGGGGIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMARLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSSITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL", "length": 596, "header": "tr|A0A3Q1LZU3-1|A0A3Q1LZU3_BOVIN Isoform 1 of Nuclear receptor subfamily 2 group C member 2 OS=Bos taurus OX=9913 GN=NR2C2 PE=3 SV=2 CANONICAL=A0A3Q1LZU3-1" }, "locus": { "chromosome": "22", "start_pos": 57295388, "end_pos": 57260572, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077868.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077868.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066416.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066416.2" } ] } }, { "isoform_ac": "A0AAA9TQJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQJ6/entry", "sequence": { "sequence": "MATSAEGLVQHRVGARQVAEVPRTQTSRPESPGMTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVAEKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDCKAETSQGALGTLANVVTSLANLSGPLNNGDTAETQPEDQSASEITRAFDTLAKALNTTDSASPPSLADGIDGSGGGGIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMARLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSSITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL", "length": 629, "header": "tr|A0AAA9TQJ6-1|A0A3Q1LZU3_BOVIN Computationally mapped isoform of Nuclear receptor subfamily 2 group C member 2 OS=Bos taurus OX=9913 GN=NR2C2 PE=3 SV=1 CANONICAL=A0A3Q1LZU3-1" }, "locus": { "chromosome": "22", "start_pos": 57354228, "end_pos": 57260572, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094354.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094354.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100643.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100643.1" } ] } }, { "isoform_ac": "E1B9Y6-1", "url": "https://www.uniprot.org/uniprotkb/E1B9Y6/entry", "sequence": { "sequence": "MTSPSPRIQIISTDSAVASPQRIQGSEPASGSLKKEKICIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVAEKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDCKAETSQGALGTLANVVTSLANLSGPLNNGDTAETQPEDQSASEITRAFDTLAKALNTTDSASPPSLADGIDGSGGGGIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMARLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSSITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL", "length": 611, "header": "tr|E1B9Y6-1|A0A3Q1LZU3_BOVIN Computationally mapped isoform of Nuclear receptor subfamily 2 group C member 2 OS=Bos taurus OX=9913 GN=NR2C2 PE=3 SV=2 CANONICAL=A0A3Q1LZU3-1" }, "locus": { "chromosome": "22", "start_pos": 57295388, "end_pos": 57260572, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018228.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018228.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018228.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018228.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505531", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505531", "resource": "KEGG Pathway" }, { "id": "R-BTA-383280", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "resource": "Reactome", "description": "Nuclear Receptor transcription pathway" }, { "id": "R-BTA-9940951", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9940951", "resource": "Reactome", "description": "Interaction of NuRD complexes with transcription factors" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UBA4-1", "protein_name": "Nuclear receptor subfamily 2 group C member 2", "gene_name": "NR2C2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKADVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEMQPEDQSASEITRAFDTLAKALNTTDSSSPPSLADGIDGSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL", "length": 596 }, "evidence": [ { "id": "A0A3Q1LZU3", "url": "https://omabrowser.org/oma/group/A0A3Q1LZU3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QF65-1", "protein_name": "Nuclear receptor subfamily 2 group C member 2 isoform X1", "gene_name": "Nr2c2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATNMEGLVQHRVGTQQVAEVPRTQTSRPESPGMTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSSKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKADVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLNESLNNGDTSEMQPEDQSASEITRAFDTLAKALNTTDSASPPSLADGIDASGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTGTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL", "length": 629 }, "evidence": [ { "id": "A0A3Q1LZU3", "url": "https://omabrowser.org/oma/group/A0A3Q1LZU3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0AB32TYQ7-1", "protein_name": "Nuclear receptor subfamily 2 group C member 2 isoform X2", "gene_name": "nr2c2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSGSPQRIQIISTEPSVTSPQRIQIVTEQQTGQKIQIVTALDSSVPKQQFLLASPDGSPAGKVLLASPESSSAKQLIFATADSLVPGRIQFVTDAVSVERLLGKGTDLSRVQPIEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKSLTYSCRSNQDCVINKHHRNRCQFCRLRKCLEMGMKMESVQSERKPIDLPREKPANCAASTEKIYIRKDLRSPLIATPTFISEKDSSRSKLLDSGMLVNIQQPLIQADGTLLLATDKTESGQGDLGTLANVVTSLANLNDSLSNGEATDGQLEESPSEITRAFDTLAKALNPGELTESQSLSEVDGVGGATIQVISRDQISPLIEVEGPLLTDTHVSFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFLALGQECNTALVRACWNELFILGLAQCAQIMSLSTILTAIVNHLQSSIQDVDKLSSERIKLVMEHIWKLQEFCNSMAKLQTDAYEYAYLKAIVLFSPDHPGLSSCSQIEKFQEKAQMELQDYVQKTYPDETYRLARILLRLPALRLMSSSITEELFFTGLIGNVPIDSIIPYILKMETADYNSQITAPSV", "length": 593 }, "evidence": [ { "id": "A0A3Q1LZU3", "url": "https://omabrowser.org/oma/group/A0A3Q1LZU3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1P0B9-1", "protein_name": "Nuclear receptor subfamily 2 group C member 2", "gene_name": "NR2C2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTSPSQRIQIISTDSSVGSPQRIQIVTDQQTGQKIQIVTAVDSSVSPKQQFILASPDGTGAGKVILAAPETSNAKQLIFTTADNVVPGRIQIVTDSASVERLLGKADVQRAQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPTNCAASTEKIYIRKDLRSPLIATPTFVADKDGARSAGLLDPGMLVNIQQPLIRDDGTILLAADSKAETSQGALGTLANVVTSLANLSDSLNNGDTSEIQQEEQSASEISRAFDTLAKALSTTDGTAVPNLADGMDPTGGGNIHVISRDQSTPIIEVEGPLLTDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQECNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKIDIDGYEYAYLKAIVLFSPDHPGLNSSTQIEKFQEKAQMELQDYVQKTYPEDTYRLARILVRLPALRLMSSSITEELFFTGLIGNVPIDSIIPYILKMETAEYNGQITGTSA", "length": 596 }, "evidence": [ { "id": "A0A3Q1LZU3", "url": "https://omabrowser.org/oma/group/A0A3Q1LZU3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P49116-1", "protein_name": "Nuclear receptor subfamily 2 group C member 2", "gene_name": "NR2C2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL", "length": 596 }, "evidence": [ { "id": "A0A3Q1LZU3", "url": "https://omabrowser.org/oma/group/A0A3Q1LZU3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P49117-1", "protein_name": "Nuclear receptor subfamily 2 group C member 2", "gene_name": "Nr2c2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSSKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKADVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLAADSKAETSQGALGTLANVVTSLANLSESLNNGDASEMQPEDQSASEITRAFDTLAKALNTTDSASPPSLADGIDASGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTGTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL", "length": 596 }, "evidence": [ { "id": "A0A3Q1LZU3", "url": "https://omabrowser.org/oma/group/A0A3Q1LZU3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P55094-1", "protein_name": "Nuclear receptor subfamily 2 group C member 2", "gene_name": "Nr2c2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTSPSPRIQIISTDSAVRSPQRIQIVTDQQTGQKLQIVTAVDASGSSKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKADVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGSRQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDASEMQPEDQSASEITRAFDTLAKALNTTDSASPPSLADGIDASGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGHEYAYLKAIVLFSPDHPGLTGTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL", "length": 596 }, "evidence": [ { "id": "A0A3Q1LZU3", "url": "https://omabrowser.org/oma/group/A0A3Q1LZU3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF18140", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-196780", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196780", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-71032", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71032", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "23720", "url": "https://www.rhea-db.org/rhea/23720", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "59520", "url": "https://www.rhea-db.org/rhea/59520", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LTS4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTS4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUQ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYL5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM69", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MM69-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM69-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N969", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N969", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N969-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N969-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S842", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S842", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S842-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S842-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXI2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABZ3NNI2", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABZ3NNI2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNI2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGFWTGAAALATAGRRGRRWPKLLMRSVALWTVKHVPHYSRRYLVVSRTLCSAGYDSNEKTFDKILIANRGEIACRVIKTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMNAIMDAVRSTRAQAVHPGYGFLSENKEFAKRLAAEDVIFIGPDTHAIQAMGDKIESKLLAKKAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDSETRRAMGEQAVALAKAVNYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIPINGWAVECRVYAEDPYKSFGLPSVGRLSQYEEPIHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMEDALDSYVIRGVTHNIALLREVIINSRFIEGDINTKFLSDVYPDGFKGHPLTETERNQFLAVASSLFVASQLRAQHFQDHESSRVPIVKPQVASWELSVKLHDEIHTVVVSSSGPTFSVEVDGSKLNVTSTWNLASPLLSVNVDGTQRTIQCLSREAGGNMSIQFLGTVDFSVVIKLLSILTLQEEIRKYKVRILTKLAAELNKFMLEKAAEDTSSILRSPMPGVVVAISVKPGDLVAEGQEICVIEAMKMQNSMTAGKTGKVKSVHCKAGDTVGEGDLLVELE", "length": 750, "header": "tr|A0A3Q1LYL5-1|A0A3Q1LYL5_BOVIN Isoform 1 of Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Bos taurus OX=9913 GN=PCCA PE=1 SV=2 CANONICAL=A0A3Q1LYL5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTS4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTS4/entry", "sequence": { "sequence": "MAGFWTGAAALATAGRRGRRWPKLLMRSVALWTVKHVPHYSRRYLVVSRTLCSAGYDSNEKTFDKILIANRGEIACRVIKTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMNAIMDAVRSTRAQAVHPGYGFLSENKEFAKRLAAEDVIFIGPDTHAIQAMGDKIESKLLAKKAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDSETRRAMGEQAVALAKAVNYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIPINGWAVECRVYAEDPYKSFGLPSVGRLSQYEEPIHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMEDALDSYVIRGVTHNIALLREVIINSRFIEGDINTKFLSDVYPDGFKGHPLTETERNQFLAVASSLFVASQLRAQHFQDHESSRVPIVKPQVASWELSVKLHDEIHTVVVSSSGPTFSHEPQKLLHSYMVEVDGSKLNVTSTWNLASPLLSVNVDGTQRTIQCLSREAGGNMSIQFLGTVVAEGQEICVIEAMKMQNSMTAGKTGKVRPQGPHLDGKQSLHLGVLDVGPGRVCATPGAGGGGLKNSCSSP", "length": 716, "header": "tr|A0A3Q1LTS4-1|A0A3Q1LYL5_BOVIN Computationally mapped isoform of Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Bos taurus OX=9913 GN=PCCA PE=1 SV=3 CANONICAL=A0A3Q1LYL5-1" }, "locus": { "chromosome": "12", "start_pos": 77171647, "end_pos": 76812962, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073154.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073154.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060748.3", "url": "https://www.ensembl.org/id/ENSBTAP00000060748.3" } ] } }, { "isoform_ac": "A0A3Q1LUQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUQ7/entry", "sequence": { "sequence": "MAGFWTGAAALATAGRRGRRWPKLLMRSVALWTVKHVPHYSRRYLVVSRTLCSAGYDSNEKTFDKILIANRGEIACRVIKTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMNAIMDAVRSTRAQAVHPGYGFLSENKEFAKRLAAEDVIFIGPDTHAIQAMGDKIESKLLAKKAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDSETRRAMGEQAVALAKAVNYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIPINGWAVECRVYAEDPYKSFGLPSVGRLSQYEEPIHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMEDALDSYVIRGVTHNIALLREVIINSRFIEGDINTKFLSDVYPDGFKGHPLTETERNQFLAVASSLFVASQLRAQHFQDHESSRVPIVKPQVASWELSVKLHDEIHTVVVSSSGPTFSHEPQKLLHSYMVEVDGSKLNVTSTWNLASPLLSVNVDGTQRTIQYKVRILTKLAAELNKFMLEKAAEDTSSILRSPMPGVVVAISVKPGDLVAEGQEICVIEAMKMQNSMTAGKTGKVKSVHCKAGDTVGEGDLLVELE", "length": 723, "header": "tr|A0A3Q1LUQ7-1|A0A3Q1LYL5_BOVIN Computationally mapped isoform of Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Bos taurus OX=9913 GN=PCCA PE=1 SV=2 CANONICAL=A0A3Q1LYL5-1" }, "locus": { "chromosome": "12", "start_pos": 77174694, "end_pos": 76812962, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080928.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080928.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064289.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064289.2" } ] } }, { "isoform_ac": "A0A3Q1LYL5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5/entry", "sequence": { "sequence": "MAGFWTGAAALATAGRRGRRWPKLLMRSVALWTVKHVPHYSRRYLVVSRTLCSAGYDSNEKTFDKILIANRGEIACRVIKTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMNAIMDAVRSTRAQAVHPGYGFLSENKEFAKRLAAEDVIFIGPDTHAIQAMGDKIESKLLAKKAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDSETRRAMGEQAVALAKAVNYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIPINGWAVECRVYAEDPYKSFGLPSVGRLSQYEEPIHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMEDALDSYVIRGVTHNIALLREVIINSRFIEGDINTKFLSDVYPDGFKGHPLTETERNQFLAVASSLFVASQLRAQHFQDHESSRVPIVKPQVASWELSVKLHDEIHTVVVSSSGPTFSVEVDGSKLNVTSTWNLASPLLSVNVDGTQRTIQCLSREAGGNMSIQFLGTVDFSVVIKLLSILTLQEEIRKYKVRILTKLAAELNKFMLEKAAEDTSSILRSPMPGVVVAISVKPGDLVAEGQEICVIEAMKMQNSMTAGKTGKVKSVHCKAGDTVGEGDLLVELE", "length": 750, "header": "tr|A0A3Q1LYL5-1|A0A3Q1LYL5_BOVIN Isoform 1 of Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Bos taurus OX=9913 GN=PCCA PE=1 SV=2 CANONICAL=A0A3Q1LYL5-1" }, "locus": { "chromosome": "12", "start_pos": 77174694, "end_pos": 76812962, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081754.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081754.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062360.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062360.2" } ] } }, { "isoform_ac": "A0A3Q1MM69-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MM69/entry", "sequence": { "sequence": "MAGFWTGAAALATAGRRGRRWPKLLMRSVALWTVKVRRLSALPSLLIHTLVSSGNTITDTTFDKILIANRGEIACRVIKTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMNAIMDAVRSTRAQAVHPGYGFLSENKEFAKRLAAEDVIFIGPDTHAIQAMGDKIESKLLAKKAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDSETRRAMGEQAVALAKAVNYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIPINGWAVECRVYAEDPYKSFGLPSVGRLSQYEEPIHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMEDALDSYVIRGVTHNIALLREVIINSRFIEGDINTKFLSDVYPDGFKGHPLTETERNQFLAVASSLFVASQLRAQHFQDHESSRVPIVKPQVASWELSVKLHDEIHTVVVSSSGPTFSHEPQKLLHSYMVEVDGSKLNVTSTWNLASPLLSVNVDGTQRTIQCLSREAGGNMSIQFLGTVYKVRILTKLAAELNKFMLEKAAEDTSSILRSPMPGVVVAISVKPGDLVAEGQEICVIEAMKMQNSMTAGKTGKVKSVHCKAGDTVGEGDLLVELE", "length": 740, "header": "tr|A0A3Q1MM69-1|A0A3Q1LYL5_BOVIN Computationally mapped isoform of Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Bos taurus OX=9913 GN=PCCA PE=1 SV=1 CANONICAL=A0A3Q1LYL5-1" }, "locus": { "chromosome": "12", "start_pos": 77174694, "end_pos": 76812962, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086788.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086788.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070478.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070478.1" } ] } }, { "isoform_ac": "A0A3Q1N969-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N969/entry", "sequence": { "sequence": "MAGFWTGAAALATAGRRGRRWPKLLMRSVALWTVKTFDKILIANRGEIACRVIKTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMNAIMDAVRSTRAQAVHPGYGFLSENKEFAKRLAAEDVIFIGPDTHAIQAMGDKIESKLLAKKAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDSETRRAMGEQAVALAKAVNYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIPINGWAVECRVYAEDPYKSFGLPSVGRLSQYEEPIHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMEDALDSYVIRGVTHNIALLREVIINSRFIEGDINTKFLSDVYPDGFKGHPLTETERNQFLAVASSLFVASQLRAQHFQDHESSRVPIVKPQVASWELSVKLHDEIHTVVVSSSGPTFSVEVDGSKLNVTSTWNLASPLLSVNVDGTQRTIQCLSREAGGNMSIQFLGTVYKVRILTKLAAELNKFMLEKAAEDTSSILRSPMPGVVVAISVKPGDLVAEGQEICVIEAMKMQNSMTAGKTGKVKSVHCKAGDTVGEGDLLVELE", "length": 704, "header": "tr|A0A3Q1N969-1|A0A3Q1LYL5_BOVIN Computationally mapped isoform of Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Bos taurus OX=9913 GN=PCCA PE=1 SV=2 CANONICAL=A0A3Q1LYL5-1" }, "locus": { "chromosome": "12", "start_pos": 77174694, "end_pos": 76812962, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086761.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086761.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067670.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067670.2" } ] } }, { "isoform_ac": "A0AAA9RXJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXJ3/entry", "sequence": { "sequence": "MLSCSSVEDSLLLSLRRLTQSSLRGRHRPGEQFVHVKMADEAVCVGPAPTSKSYLNMNAIMDAVRSTRAQAVHPGYGFLSENKEFAKRLAAEDVIFIGPDTHAIQAMGDKIESKLLAKKAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDSETRRAMGEQAVALAKAVNYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIPINGWAVECRVYAEDPYKSFGLPSVGRLSQYEEPIHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMEDALDSYVIRGVTHNIALLREVIINSRFIEGDINTKFLSDVYPDGFKGHPLTETERNQFLAVASSLFVASQLRAQHFQDHESSRVPIVKPQVASWELSVKLHDEIHTVVVSSSGPTFSHEPQKLLHSYMVEVDGSKLNVTSTWNLASPLLSVNVDGTQRTIQCLSREAGGNMSIQFLGTVYKVRILTKLAAELNKFMLEKAAEDTSSILRSPMPGVVVAISVKPGDLVAEGQEICVIEAMKMQNSMTAGKTGKVKSVHCKAGDTVGEGDLLVELE", "length": 674, "header": "tr|A0AAA9RXJ3-1|A0A3Q1LYL5_BOVIN Computationally mapped isoform of Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Bos taurus OX=9913 GN=PCCA PE=1 SV=1 CANONICAL=A0A3Q1LYL5-1" }, "locus": { "chromosome": "12", "start_pos": 77174694, "end_pos": 76833500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111267.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111267.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075871.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075871.1" } ] } }, { "isoform_ac": "A0AAA9S842-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S842/entry", "sequence": { "sequence": "MAGFWTGAAALATAGRRGRRWPKLLMRSVALWTVKHVPHYSRRYLVVSRTLCSAGYDSNEKVHVKMADEAVCVGPAPTSKSYLNMNAIMDAVRSTRAQAVHPGYGFLSENKEFAKRLAAEDVIFIGPDTHAIQAMGDKIESKLLAKKAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDSETRRAMGEQAVALAKAVNYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIPINGWAVECRVYAEDPYKSFGLPSVGRLSQYEEPIHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMEDALDSYVIRGVTHNIALLREVIINSRFIEGDINTKFLSDVYPDGFKGHPLTETERNQFLAVASSLFVASQLRAQHFQDHESSRVPIVKPQVASWELSVKLHDEIHTVVVSSSGPTFSVEVDGSKLNVTSTWNLASPLLSVNVDGTQRTIQCLSREAGGNMSIQFLGTVYKVRILTKLAAELNKFMLEKAAEDTSSILRSPMPGVVVAISVKPGDLVAEGQEICVIEAMKMQNSMTAGKTGKVKSVHCKAGDTVGEGDLLVELE", "length": 691, "header": "tr|A0AAA9S842-1|A0A3Q1LYL5_BOVIN Computationally mapped isoform of Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Bos taurus OX=9913 GN=PCCA PE=1 SV=1 CANONICAL=A0A3Q1LYL5-1" }, "locus": { "chromosome": "12", "start_pos": 77174694, "end_pos": 76812962, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097157.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097157.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078323.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078323.1" } ] } }, { "isoform_ac": "A0AAA9SXI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXI2/entry", "sequence": { "sequence": "MAGFWTGAAALATAGRRGRRWPKLLMRSVALWTVKHVPHYSRRYLVVSRTLCSAGYDSNEKTFDKILIANRGEIACRVIKTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMNAIMDAVRSTRAQAVHPGYGFLSENKEFAKRLAAEDVIFIGPDTHAIQAMGDKIESKLLAKKAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDSETRRAMGEQAVALAKAVNYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIPINGWAVECRVYAEDPYKSFGLPSVGRLSQYEEPIHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMEDALDSYVIRGVTHNIALLREVIINSRFIEGDINTKFLSDVYPDGFKGHPLTETERNQFLAVASSLFVASQLRAQHFQDHESSRVPIVKPQVASWELSVKLHDEIHTVVVSSSGPTFSVEVDGSKLNVTSTWNLASPLLSVNVDGTQRTIQVAEGQEICVIEAMKMQNSMTAGKTGKVKSVHCKAGDTVGEGDLLVELE", "length": 665, "header": "tr|A0AAA9SXI2-1|A0A3Q1LYL5_BOVIN Computationally mapped isoform of Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Bos taurus OX=9913 GN=PCCA PE=1 SV=1 CANONICAL=A0A3Q1LYL5-1" }, "locus": { "chromosome": "12", "start_pos": 77174694, "end_pos": 76812962, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094365.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094365.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088015.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088015.1" } ] } }, { "isoform_ac": "A0ABZ3NNI2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNI2/entry", "sequence": { "sequence": "MAGFWTGAAALATAGRRGRRWPKLLMRSVALWTVKHVPHYSRRYLVVSRTLCSAGYDSNEKTFDKILIANRGEIACRVIKTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMNAIMDAVRSTRAQAVHPGYGFLSENKEFAKRLAAEDVIFIGPDTHAIQAMGDKIESKLLAKKAKVNTIPGFDGVVKDADEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRFSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDSETRRAMGEQAVALAKAVNYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIPINGWAVECRVYAEDPYKSFGLPSVGRLSQYEEPIHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMEDALDSYVIRGVTHNIALLREVIINSRFIEGDINTKFLSDVYPDGFKGHPLTETERNQFLAVASSLFVASQLRAQHFQDHESSRVPIVKPQVASWELSVKLHDEIHTVVVSSSGPTFSVEVDGSKLNVTSTWNLASPLLSVNVDGTQRTIQCLSREAGGNMSIQFLGTVVAEGQEICVIEAMKMQNSMTAGKTGKVRPQGPHLDGKQSLHLGVLDVGPGRVCATPGAGGGGLKNSCSSP", "length": 705, "header": "tr|A0ABZ3NNI2-1|A0ABZ3NNI2_BOVIN Computationally mapped isoform of Propionyl-CoA carboxylase subunit alpha OS=Bos taurus OX=9913 GN=PCCA PE=1 SV=1 CANONICAL=A0A3Q1LYL5-1" }, "locus": { "chromosome": "12", "start_pos": 77171647, "end_pos": 76812962, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014120.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014120.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014120.7", "url": "https://www.ensembl.org/id/ENSBTAP00000014120.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:614302", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614302", "resource": "KEGG Pathway" }, { "id": "R-BTA-196780", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196780", "resource": "Reactome", "description": "Biotin transport and metabolism" }, { "id": "R-BTA-71032", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71032", "resource": "Reactome", "description": "Propionyl-CoA catabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5" } ], "pmid": "" }, { "name": "ligase activity", "id": "GO:0016874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016874", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5" } ], "pmid": "" }, { "name": "propionyl-CoA carboxylase activity", "id": "GO:0004658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004658", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5" } ], "pmid": "" }, { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5" } ], "pmid": "" }, { "name": "succinyl-CoA biosynthetic process", "id": "GO:1901290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901290", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 328, "end_pos": 330, "annotation": "n_glycosylation_sequon" }, { "start_pos": 593, "end_pos": 595, "annotation": "n_glycosylation_sequon" }, { "start_pos": 626, "end_pos": 628, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23720", "name": "", "equation": "propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2TBR0-1", "A0A3Q1LYL5-1" ], "evidence": [ { "id": "23720", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23720" } ] }, { "id": "59520", "name": "", "equation": "butanoyl-CoA + hydrogencarbonate + ATP = (2S)-ethylmalonyl-CoA + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2TBR0-1", "A0A3Q1LYL5-1" ], "evidence": [ { "id": "59520", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/59520" } ] }, { "id": "R-BTA-2993447", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-199207" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LYL5-1", "Q2TBR0-1" ], "evidence": [ { "id": "R-BTA-2993447", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2993447" } ] }, { "id": "R-BTA-3323111", "name": "Cytosolic carboxylases translocate to mitochondrial matrix", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LYL5-1", "Q2TBR0-1", "A0A3Q1LRD6-1", "Q29RK2-1", "E1BPP6-1" ], "evidence": [ { "id": "R-BTA-3323111", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3323111" } ] }, { "id": "R-BTA-71031", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-70843" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LYL5-1", "Q2TBR0-1" ], "evidence": [ { "id": "R-BTA-71031", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71031" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-199207", "participant_name": "Btn [cytosol]", "crossref": [ { "id": "15956", "database": "ChEBI", "url": "" }, { "id": "8143739", "database": "PubChem Substance", "url": "" }, { "id": "C00120", "database": "COMPOUND", "url": "" }, { "id": "4787", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000035024346", "database": "ZINC", "url": "" }, { "id": "HMDB0000030", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-70843", "participant_name": "PROP-CoA [mitochondrial matrix]", "crossref": [ { "id": "57392", "database": "ChEBI", "url": "" }, { "id": "ZINC000008551120", "database": "ZINC", "url": "" }, { "id": "C00100", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LRD6", "gene_name": "MCCC1", "activity": [ { "ec_number": "6.4.1.4", "activity": "3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LRD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRD6" } ] }, { "ec_number": "6.4.1.4", "activity": "", "evidence": [ { "id": "A0A3Q1LRD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRD6" } ] } ] }, { "uniprot_ac": "A0A3Q1LYL5", "gene_name": "PCCA", "activity": [ { "ec_number": "6.4.1.3", "activity": "propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5" } ] }, { "ec_number": "6.4.1.3", "activity": "", "evidence": [ { "id": "A0A3Q1LYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5" } ] } ] }, { "uniprot_ac": "E1BPP6", "gene_name": "MCCC2", "activity": [ { "ec_number": "6.4.1.4", "activity": "3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP6" } ] }, { "ec_number": "6.4.1.4", "activity": "", "evidence": [ { "id": "E1BPP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP6" } ] } ] }, { "uniprot_ac": "Q29RK2", "gene_name": "PC", "activity": [ { "ec_number": "6.4.1.1", "activity": "hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+).", "evidence": [ { "id": "Q29RK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RK2" } ] }, { "ec_number": "6.4.1.1", "activity": "", "evidence": [ { "id": "Q29RK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RK2" } ] } ] }, { "uniprot_ac": "Q2TBR0", "gene_name": "PCCB", "activity": [ { "ec_number": "6.4.1.3", "activity": "propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBR0" } ] }, { "ec_number": "6.4.1.3", "activity": "", "evidence": [ { "id": "Q2TBR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBR0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LYL5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 750, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LYL5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LYL5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LYL5", 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], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Lipoyl-binding", "eco_id": "ECO_0000259", "start_pos": 675, "end_pos": 750, "start_aa": "Lys", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.4.1.3", "ec_name": "propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+).", "evidence": [ { "id": "6.4.1.3", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3" }, { "id": "6.4.1.3", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.4.1.3" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 328, "end_pos": 330 }, { "start_pos": 593, "end_pos": 595 }, { "start_pos": 626, "end_pos": 628 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"https://www.uniprot.org/uniprotkb/A0A3Q1M1E4/entry#names_and_taxonomy" } ] }, { "name": "adhesion G protein-coupled receptor E1 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_024850696", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850696" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1E4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1E4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC508459", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1E4", "locus": {} } ], "crossref": [ { "id": "A0A3Q1M1E4", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M1E4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007901", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007901", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15439", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15439", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508459", "url": "https://www.ncbi.nlm.nih.gov/gene/508459", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001740", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001740", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052235", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052235", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057244", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057244", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12011", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12011", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12011:SF449", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12011:SF449", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24039", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24039", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24039:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24039:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24050", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24050", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24050:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24050:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-373080", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373080", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024850696", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850696", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTX3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTX3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTX3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXX4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXX4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXX4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1E4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1E4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1E4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7G8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7G8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7G8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7G8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M865", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M865", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M865-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M865-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVG7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVG7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWI3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWI3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NV22", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NV22-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV22-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P134", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P134", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P134-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P134-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNX3", "url": "https://www.uniprot.org/uniprotkb/E1BNX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNX3-1", "url": "https://www.uniprot.org/uniprotkb/E1BNX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWSFSFLLFWGCCGIYTWGMLTLPTLGSMTRHEQPRWSSSSLDGNGCTDTTMCPAYATCTNTSRSYYCSCKRGFLSSNGLKTFKGPGVECKDIDECSQSPTPCGPNSICRNLPGRYRCSCMTGFSSPTGNNWISGKQGHFTCRDVDECANPRSCPEHSTCHNSPGSYSCVCNPGFQSRSGRKSFQGLKEMCEDVDECASPRSCPEHSTCHNSLGSYSCACNPGYNSRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSGSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKSFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKSFQGPGEMCQDIDECSQTPPTCGPNSSCRNLPGRYECSCLTGFSSPTGNNWIPGKSGHFTCTDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKNFQGPGETCEDVDECSRNSTLCGPSSVCTNIPGKYSCSCLPGFFSPGVWSPEKPEAFKCADIDECLQDPSRCGPDSVCTNTLGSYSCGCVVGFHPNPEGSWKHGNFSCQRIPFKCKDDVIPSNMQVQLCHAGAAVEPKYVSFCALMNATLSVLDNVCENKTTVVSLKSTAKRLDSVIEKTSKWSNFTKEETSTLATVLLESVESTTLAAFLKPSANVSQTIQTKHLDIESKVIDKECTKENETFKLKAKGDEMKIWCSTIKESESTGINGVAFVSFSGMESILDERFLKDLQIPWASSKKKLKMNSRVVGGIITGGKKDGFSKPVIYTLENIKPKQDFESAICVSWKPDVEGGRWTPSGCVLLEASKTHTVCGCNQMVNLAVIMASGEVTMEFTLYLISHVGTIISLVCLAMAIITFLLCRTLRNQNTYIHLHLCICLFLAKMLFLTGVDKTDNQMGCALIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLYLCAFGYGLPGLVVAVSAGLQPQGYGMYNRCWLNTETGFIWSFLGPVCTIIVVNSILLTWTLCILRQKLSSVNAEVSTLKDTRLLTFKAFAQIFILGCSWVLGIFQIGPMANIMAYLFTIINSLQGAFIFLIHCVLSRQVREEYRRCTTRKTKPSSETQTSGILLSSVPSTSKTG", "length": 1538, "header": "tr|A0A3Q1M1E4-1|A0A3Q1M1E4_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC508459 PE=3 SV=2 CANONICAL=A0A3Q1M1E4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTX3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTX3/entry", "sequence": { "sequence": "MWSFSFLLFWGCCGIYTWGMLTLPTLGSMTRHEQPRWSSSSLDGNGCTDTTMCPAYATCTNTSRSYYCSCKRGFLSSNGLKTFKGPGVECKDIDECSQSPTPCGPNSICRNLPGRYRCSCMTGFSSPTGNNWISGKQGHFTCRDVDECANPRSCPEHSTCHNSPGSYSCVCNPGFQSRSGRKSFQGLKEMCEDVDECASPRSCPEHSTCHNSLGSYSCACNPGYNSRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSGSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKSFQGPGEMCQDIDECSQTPPTCGPNSSCRNLPGRYECSCLTGFSSPTGNNWIPGKSGHFTCTDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKNFQGPGETCEDVDECSRNSTLCGPSSVCTNIPGKYSCSCLPGFFSPGVWSPEKPEAFKCADIDECLQDPSRCGPDSVCTNTLGSYSCGCVVGFHPNPEGSWKHGNFSCQRIPFKCKDDVIPSNMQVQLCHAGAAVEPKYVSFCALMNATLSVLDNVCENKTTVVSLKSTAKRLDSVIEKTSKWSNFTKEETSTLATVLLESVESTTLAAFLKPSANVSQTIQTKHLDIESKVIDKECTKENETFKLKAKGDEMKIWCSTIKESESTGINGVAFVSFSGMESILDERFLKDLQIPWASSKKKLKMNSRVVGGIITGGKKDGFSKPVIYTLENIKPKQDFESAICVSWKPDVEGGRWTPSGCVLLEASKTHTVCGCNQMVNLAVIMASGEVTMEFTLYLISHVGTIISLVCLAMAIITFLLCRTLRNQNTYIHLHLCICLFLAKMLFLTGVDKTDNQMGCALIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLYLCAFGYGLPGLVVAVSAGLQPQGYGMYNRCWLNTETGFIWSFLGPVCTIIVVNSILLTWTLCILRQKLSSVNAEVSTLKDTRLLTFKAFAQIFILGCSWVLGIFQIGPMANIMAYLFTIINSLQGAFIFLIHCVLSRQVREEYRRCTTRKTKPSSETQTSGILLSSVPSTSKTG", "length": 1397, "header": "tr|A0A3Q1LTX3-1|A0A3Q1M1E4_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC508459 PE=3 SV=2 CANONICAL=A0A3Q1M1E4-1" }, "locus": { "chromosome": "7", "start_pos": 17633111, "end_pos": 17558233, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070022.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070022.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060551.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060551.2" } ] } }, { "isoform_ac": "A0A3Q1LXX4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXX4/entry", "sequence": { "sequence": "MWSFSFLLFWGCCGIYTWGMLTLPTLGSMTRHEQPRWSSSSLDGNGCTDTTMCPAYATCTNTSRSYYCSCKRGFLSSNGLKTFKGPGVECKDIDECSQSPTPCGPNSICRNLPGRYRCSCMTGFSSPTGNNWISGKQGHFTCRDVDECANPRSCPEHSTCHNSPGSYSCVCNPGFQSRSGRKSFQGLKEMCEDVDECASPRSCPEHSTCHNSLGSYSCACNPGYNSRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSGSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKSFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKSFQGPGEMCQDIDECSQTPPTCGPNSSCRNLPGRYECSCLTGFSSPTGNNWIPGKSGHFTCTDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKNFQGPGETCEDVDECSRNSTLCGPSSVCTNIPGKYSCSCLPGFFSPGVWSPEKPEAFKCADIDECLQDPSRCGPDSVCTNTLGSYSCGCVVGFHPNPEGSWKHGNFSCQRIPFKCKDDVIPSNMQVQLCHAGAAVEPKYVSFCALMNATLSVLDNVCENKTTVVSLKSTAKRLDSVIEKTSKWSNFTKEETSTLATVLLESVESTTLAAFLKPSANVSQTIQTKHLDIESKVIDKECTKENETFKLKAKGDEMKIWCSTIKESESTGINGVAFVSFSGMESILDERFLKDLQIPWASSKKKLKMNSRVVGGIITGGKKDGFSKPVIYTLENIKPKQDFESAICVSWKPDVEGGRWTPSGCVLLEASKTHTVCGCNQMVNLAVIMASGEVTMEFTLYLISHVGTIISLVCLAMAIITFLLCRTLRNQNTYIHLHLCICLFLAKMLFLTGVDKTDNQMGCALIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLYLCAFGYGLPGLVVAVSAGLQPQGYGMYNRCWLNTETGFIWSFLGPVCTIIVVNSILLTWTLCILRQKLSSVNAEVSTLKDTRLLTFKAFAQIFILGCSWVLGIFQIGPMANIMAYLFTIINSLQGAFIFLIHCVLSRQVREEYRRCTTRKTKPSSETQTSGILLSSVPSTSKTG", "length": 1440, "header": "tr|A0A3Q1LXX4-1|A0A3Q1LXX4_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor E1 OS=Bos taurus OX=9913 GN=LOC508459 PE=3 SV=3 CANONICAL=A0A3Q1M1E4-1" }, "locus": { "chromosome": "7", "start_pos": 17633111, "end_pos": 17558233, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068991.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068991.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062100.3", "url": "https://www.ensembl.org/id/ENSBTAP00000062100.3" } ] } }, { "isoform_ac": "A0A3Q1M1E4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1E4/entry", "sequence": { "sequence": "MWSFSFLLFWGCCGIYTWGMLTLPTLGSMTRHEQPRWSSSSLDGNGCTDTTMCPAYATCTNTSRSYYCSCKRGFLSSNGLKTFKGPGVECKDIDECSQSPTPCGPNSICRNLPGRYRCSCMTGFSSPTGNNWISGKQGHFTCRDVDECANPRSCPEHSTCHNSPGSYSCVCNPGFQSRSGRKSFQGLKEMCEDVDECASPRSCPEHSTCHNSLGSYSCACNPGYNSRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSGSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKSFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKSFQGPGEMCQDIDECSQTPPTCGPNSSCRNLPGRYECSCLTGFSSPTGNNWIPGKSGHFTCTDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKNFQGPGETCEDVDECSRNSTLCGPSSVCTNIPGKYSCSCLPGFFSPGVWSPEKPEAFKCADIDECLQDPSRCGPDSVCTNTLGSYSCGCVVGFHPNPEGSWKHGNFSCQRIPFKCKDDVIPSNMQVQLCHAGAAVEPKYVSFCALMNATLSVLDNVCENKTTVVSLKSTAKRLDSVIEKTSKWSNFTKEETSTLATVLLESVESTTLAAFLKPSANVSQTIQTKHLDIESKVIDKECTKENETFKLKAKGDEMKIWCSTIKESESTGINGVAFVSFSGMESILDERFLKDLQIPWASSKKKLKMNSRVVGGIITGGKKDGFSKPVIYTLENIKPKQDFESAICVSWKPDVEGGRWTPSGCVLLEASKTHTVCGCNQMVNLAVIMASGEVTMEFTLYLISHVGTIISLVCLAMAIITFLLCRTLRNQNTYIHLHLCICLFLAKMLFLTGVDKTDNQMGCALIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLYLCAFGYGLPGLVVAVSAGLQPQGYGMYNRCWLNTETGFIWSFLGPVCTIIVVNSILLTWTLCILRQKLSSVNAEVSTLKDTRLLTFKAFAQIFILGCSWVLGIFQIGPMANIMAYLFTIINSLQGAFIFLIHCVLSRQVREEYRRCTTRKTKPSSETQTSGILLSSVPSTSKTG", "length": 1538, "header": "tr|A0A3Q1M1E4-1|A0A3Q1M1E4_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC508459 PE=3 SV=2 CANONICAL=A0A3Q1M1E4-1" }, "locus": { "chromosome": "7", "start_pos": 17633111, "end_pos": 17558233, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070271.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070271.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067135.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067135.2" } ] } }, { "isoform_ac": "A0A3Q1M7G8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7G8/entry", "sequence": { "sequence": "MWSFSFLLFWGCCGIYTWGMLTLPTLGSMTRHEQPRWSSSSLDGNGCTDTTMCPAYATCTNTSRSYYCSCKRGFLSSNGLKTFKGPGVECKDIDECSQSPTPCGPNSICRNLPGRYRCSCMTGFSSPTGNNWISGKQGHFTCRDVDECANPRSCPEHSTCHNSPGSYSCVCNPGFQSRSGRKSFQGLKEMCEDVDECASPRSCPEHSTCHNSLGSYSCACNPGYNSRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKSFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKSFQGPGEMCQDIDECSQTPPTCGPNSSCRNLPGRYECSCLTGFSSPTGNNWIPGKSGHFTCTDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKNFQGPGETCEDVDECSRNSTLCGPSSVCTNIPGKYSCSCLPGFFSPGVWSPEKPEAFKCADIDECLQDPSRCGPDSVCTNTLGSYSCGCVVGFHPNPEGSWKHGNFSCQRIPFKCKDDVIPSNMQVQLCHAGAAVEPKYVSFCALMNATLSVLDNVCENKTTVVSLKSTAKRLDSVIEKTSKWSNFTKEETSTLATVLLESVESTTLAAFLKPSANVSQTIQTKHLDIESKVIDKECTKENETFKLKAKGDEMKIWCSTIKESESTGINGVAFVSFSGMESILDERFLKDLQIPWASSKKKLKMNSRVVGGIITGGKKDGFSKPVIYTLENIKPKQDFESAICVSWKPDVEGGRWTPSGCVLLEASKTHTVCGCNQMVNLAVIMASGEVTMEFTLYLISHVGTIISLVCLAMAIITFLLCRTLRNQNTYIHLHLCICLFLAKMLFLTGVDKTDNQMGCALIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLYLCAFGYGLPGLVVAVSAGLQPQGYGMYNRCWLNTETGFIWSFLGPVCTIIVVNSILLTWTLCILRQKLSSVNAEVSTLKDTRLLTFKAFAQIFILGCSWVLGIFQIGPMANIMAYLFTIINSLQGAFIFLIHCVLSRQVREEYRRCTTRKTKPSSETQTSGILLSSVPSTSKTG", "length": 1250, "header": "tr|A0A3Q1M7G8-1|A0A3Q1M1E4_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC508459 PE=3 SV=3 CANONICAL=A0A3Q1M1E4-1" }, "locus": { "chromosome": "7", "start_pos": 17633111, "end_pos": 17558233, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082801.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082801.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066320.3", "url": "https://www.ensembl.org/id/ENSBTAP00000066320.3" } ] } }, { "isoform_ac": "A0A3Q1M865-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M865/entry", "sequence": { "sequence": "MWSFSFLLFWGCCGIYTWGMLTLPTLGSMTRHEQPRWSSSSLDGNGCTDTTMCPAYATCTNTSRSYYCSCKRGFLSSNGLKTFKGPGVECKDIDECSQSPTPCGPNSICRNLPGRYRCSCMTGFSSPTGNNWISGKQGHFTCRDVDECANPRSCPEHSTCHNSPGSYSCVCNPGFQSRSGRKSFQGLKEMCEDVDECASPRSCPEHSTCHNSLGSYSCACNPGYNSRSGKKTFQGPGETCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSGSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKSFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKSFQGPGEMCQDIDECSQTPPTCGPNSSCRNLPGRYECSCLTGFSSPTGNNWIPGKSGHFTCTDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKNFQGPGETCEDVDECSRNSTLCGPSSVCTNIPGKYSCSCLPGFFSPGVWSPEKPEAFKCADIDECLQDPSRCGPDSVCTNTLGSYSCGCVVGFHPNPEGSWKHGNFSCQRIPFKCKDDVIPSNMQVQLCHAGAAVEPKYVSFCALMNATLSVLDNVCENKTTVVSLKSTAKRLDSVIEKTSKWSNFTKEETSTLATVLLESVESTTLAAFLKPSANVSQTIQTKHLDIESKVIDKECTKENETFKLKAKGDEMKIWCSTIKESESTGINGVAFVSFSGMESILDERFLKDLQIPWASSKKKLKMNSRVVGGIITGGKKDGFSKPVIYTLENIKPKQDFESAICVSWKPDVEGGRWTPSGCVLLEASKTHTVCGCNQMVNLAVIMASGEVTMEFTLYLISHVGTIISLVCLAMAIITFLLCRTLRNQNTYIHLHLCICLFLAKMLFLTGVDKTDNQMGCALIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLYLCAFGYGLPGLVVAVSAGLQPQGYGMYNRCWLNTETGFIWSFLGPVCTIIVVNSILLTWTLCILRQKLSSVNAEVSTLKDTRLLTFKAFAQIFILGCSWVLGIFQIGPMANIMAYLFTIINSLQGAFIFLIHCVLSRQVREEYRRCTTRKTKPSSETQTSGILLSSVPSTSKTG", "length": 1489, "header": "tr|A0A3Q1M865-1|A0A3Q1M1E4_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC508459 PE=3 SV=1 CANONICAL=A0A3Q1M1E4-1" }, "locus": { "chromosome": "7", "start_pos": 17633111, "end_pos": 17558233, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068545.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068545.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064603.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064603.2" } ] } }, { "isoform_ac": "A0A3Q1MVG7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVG7/entry", "sequence": { "sequence": "MWSFSFLLFWGCCGIYTWGMLTLPTLGSMTRHEQPRWSSSSLDGNGCTDTTMCPAYATCTNTSRSYYCSCKRGFLSSNGLKTFKGPGVECKDIDECSQSPTPCGPNSICRNLPGRYRCSCMTGFSSPTGNNWISGKQGHFTCRDVDECANPRSCPEHSTCHNSPGSYSCVCNPGFQSRSGRKSFQGLKEMCEDVDECASPRSCPEHSTCHNSLGSYSCACNPGYNSRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSGSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKSFQGPGEMCQDIDECSQTPPTCGPNSSCRNLPGRYECSCLTGFSSPTGNNWIPGKSGHFTCTDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKNFQGPGETCEDVDECSRNSTLCGPSSVCTNIPGKYSCSCLPGFFSPGVWSPEKPEAFKCADIDECLQDPSRCGPDSVCTNTLGSYSCGCVVGFHPNPEGSWKHGNFSCQRIPFKCKDDVIPSNMQVQLCHAGAAVEPKYVSFCALMNATLSVLDNVCENKTTVVSLKSTAKRLDSVIEKTSKWSNFTKEETSTLATVLLESVESTTLAAFLKPSANVSQTIQTKHLDIESKVIDKECTKENETFKLKAKGDEMKIWCSTIKESESTGINGVAFVSFSGMESILDERFLKDLQIPWASSKKKLKMNSRVVGGIITGGKKDGFSKPVIYTLENIKPKQDFESAICVSWKPDVEGGRWTPSGCVLLEASKTHTVCGCNQMVNLAVIMASGEVTMEFTLYLISHVGTIISLVCLAMAIITFLLCRTLRNQNTYIHLHLCICLFLAKMLFLTGVDKTDNQMGCALIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLYLCAFGYGLPGLVVAVSAGLQPQGYGMYNRCWLNTETGFIWSFLGPVCTIIVVNSILLTWTLCILRQKLSSVNAEVSTLKDTRLLTFKAFAQIFILGCSWVLGIFQIGPMANIMAYLFTIINSLQGAFIFLIHCVLSRQVREEYRRCTTRKTKPSSETQTSGILLSSVPSTSKTG", "length": 1348, "header": "tr|A0A3Q1MVG7-1|A0A3Q1M1E4_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC508459 PE=3 SV=1 CANONICAL=A0A3Q1M1E4-1" }, "locus": { "chromosome": "7", "start_pos": 17633111, "end_pos": 17558233, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076241.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076241.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059020.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059020.2" } ] } }, { "isoform_ac": "A0A3Q1MWI3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWI3/entry", "sequence": { "sequence": "MWSFSFLLFWGCCGIYTWGMLTLPTLGSMTRHEQPRWSSSSLDGNGCTDTTMCPAYATCTNTSRSYYCSCKRGFLSSNGLKTFKGPGVECKDIDECSQSPTPCGPNSICRNLPGRYRCSCMTGFSSPTGNNWISGKQGHFTCRDVDECANPRSCPEHSTCHNSPGSYSCVCNPGFQSRSGRKSFQGLKEMCEDVDECASPRSCPEHSTCHNSLGSYSCACNPGYNSRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSGSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKSFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKSFQGPGEMCQDIDECSQTPPTCGPNSSCRNLPGRYECSCLTGFSSPTGNNWIPGKSGHFTCTDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKNFQGPGETCEDVDECSRNSTLCGPSSVCTNIPGKYSCSCLPGFFSPGVWSPEKPEAFKCADIDECLQDPSRCGPDSVCTNTLGSYSCGCVVGFHPNPEGSWKHGNFSCQRIPFKCKDDVIPSNMQVQLCHAGAAVEPKYVSFCALMNATLSVLDNVCENKTTVVSLKSTAKRLDSVIEKTSKWSNFTKEETSTLATVLLESVESTTLAAFLKPSANVSQTIQTKHLDIESKVIDKECTKENETFKLKAKGDEMKIWCSTIKESESTGINGVAFVSFSGMESILDERFLKDLQIPWASSKKKLKMNSRVVGGIITGGKKDGFSKPVIYTLENIKPKQDFESAICVSWKPDVEGGRWTPSGCVLLEASKTHTVCGCNQMVNLAVIMASGEVTMEFTLYLISHVGTIISLVCLAMAIITFLLCRTLRNQNTYIHLHLCICLFLAKMLFLTGVDKTDNQMGCALIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLYLCAFGYGLPGLVVAVSAGLQPQGYGMYNRCWLNTETGFIWSFLGPVCTIIVVNSILLTWTLCILRQKLSSVNAEVSTLKDTRLLTFKAFAQIFILGCSWVLGIFQIGPMANIMAYLFTIINSLQGAFIFLIHCVLSRQVREEYRRCTTRKTKPSSETQTSGILLSSVPSTSKTG", "length": 1489, "header": "tr|A0A3Q1MWI3-1|A0A3Q1M1E4_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC508459 PE=3 SV=2 CANONICAL=A0A3Q1M1E4-1" }, "locus": { "chromosome": "7", "start_pos": 17633111, "end_pos": 17558233, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085632.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085632.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059832.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059832.2" } ] } }, { "isoform_ac": "A0ABI0NV22-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV22/entry", "sequence": { "sequence": "MWSFSFLLFWGCCGIYTWGMLTLPTLGSMTRHEQPRWSSSSLDGNGCTDTTMCPAYATCTNTSRSYYCSCKRGFLSSNGLKTFKGPGVECKDIDECSQSPTPCGPNSICRNLPGRYRCSCMTGFSSPTGNNWISGKQGHFTCRDVDECANPRSCPEHSTCHNSPGSYSCVCNPGFQSRSGRKSFQGLKEMCEDVDECASPRSCPEHSTCHNSLGSYSCACNPGYNSRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSGSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKSFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKSFQGPGEMCQDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKNFQGPGETCEDVDECSRNSTLCGPSSVCTNIPGKYSCSCLPGFFSPGVWSPEKPEAFKCADIDECLQDPSRCGPDSVCTNTLGSYSCGCVVGFHPNPEGSWKHGNFSCQRIPFKCKDDVIPSNMQVQLCHAGAAVEPKYVSFCALMNATLSVLDNVCENKTTVVSLKSTAKRLDSVIEKTSKWSNFTKEETSTLATVLLESVESTTLAAFLKPSANVSQTIQTKHLDIESKVIDKECTKENETFKLKAKGDEMKIWCSTIKESESTGINGVAFVSFSGMESILDERFLKDLQIPWASSKKKLKMNSRVVGGIITGGKKDGFSKPVIYTLENIKPKQDFESAICVSWKPDVEGGRWTPSGCVLLEASKTHTVCGCNQMVNLAVIMASGEVTMEFTLYLISHVGTIISLVCLAMAIITFLLCRTLRNQNTYIHLHLCICLFLAKMLFLTGVDKTDNQMGCALIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLYLCAFGYGLPGLVVAVSAGLQPQGYGMYNRCWLNTETGFIWSFLGPVCTIIVVNSILLTWTLCILRQKLSSVNAEVSTLKDTRLLTFKAFAQIFILGCSWVLGIFQIGPMANIMAYLFTIINSLQGAFIFLIHCVLSRQVREEYRRCTTRKTKPSSETQTSGILLSSVPSTSKTG", "length": 1486, "header": "tr|A0ABI0NV22-1|A0ABI0NV22_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor E1 OS=Bos taurus OX=9913 GN=LOC508459 PE=3 SV=1 CANONICAL=A0A3Q1M1E4-1" }, "locus": { "chromosome": "7", "start_pos": 17633111, "end_pos": 17558233, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146438.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146438.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105205.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105205.1" } ] } }, { "isoform_ac": "A0ABI0P134-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P134/entry", "sequence": { "sequence": "MWSFSFLLFWGCCGIYTWGMLTLPTLGSMTRHEQPRWSSSSLDGNGCTDTTMCPAYATCTNTSRSYYCSCKRGFLSSNGLKTFKGPGVECKDIDECSQSPTPCGPNSICRNLPGRYRCSCMTGFSSPTGNNWISGKQGHFTCRDVDECANPRSCPEHSTCHNSPGSYSCVCNPGFQSRSGRKSFQGLKEMCEDVDECASPRSCPEHSTCHNSLGSYSCACNPGYNSRSGKKTFQGPGETCQDVDECANPRSCPDHSTCHNSLGNYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKTFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGRKSFQGPGEMCQDVDECANPRSCPEHSTCHNSVGSYSCACNSGYISRSGKKSFQGPGETCQDIDECSQKPPPCGPNSRCRNLPGRYECSCLTGFSSPTGNNWISGKPGHFTCTDINECLSHGVCPEHSECTNSLGSYRCSCKVGFTSGNSTCEDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKSFQGPGEMCQDIDECSQTPPTCGPNSSCRNLPGRYECSCLTGFSSPTGNNWIPGKSGHFTCTDVDECANPRSCPEHSTCHNSLGSYSCVCNPGFQSRSGKKNFQGPGETCEDVDECSRNSTLCGPSSVCTNIPGKYSCSCLPGFFSPGVWSPEKPEAFKCADIDECLQDPSRCGPDSVCTNTLGSYSCGCVVGFHPNPEGSWKHGNFSCQRIPFKCKDDVIPSNMQVQLCHAGAAVEPKYVSFCALMNATLSVLDNVCENKTTVVSLKSTAKRLDSVIEKTSKWSNFTKEETSTLATVLLESVESTTLAAFLKPSANVSQTIQTKHLDIESKVIDKECTKENETFKLKAKGDEMKIWCSTIKESESTGINGVAFVSFSGMESILDERFLKDLQIPWASSKKKLKMNSRVVGGIITGGKKDGFSKPVIYTLENIKPKQDFESAICVSWKPDVEGGRWTPSGCVLLEASKTHTVCGCNQMVNLAVIMASGEVTMEFTLYLISHVGTIISLVCLAMAIITFLLCRTLRNQNTYIHLHLCICLFLAKMLFLTGVDKTDNQMGCALIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLYLCAFGYGLPGLVVAVSAGLQPQGYGMYNRCWLNTETGFIWSFLGPVCTIIVVNSILLTWTLCILRQKLSSVNAEVSTLKDTRLLTFKAFAQIFILGCSWVLGIFQIGPMANIMAYLFTIINSLQGAFIFLIHCVLSRQVREEYRRCTTRKTKPSSETQTSGILLSSVPSTSKTG", "length": 1440, "header": "tr|A0ABI0P134-1|A0ABI0P134_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor E1 OS=Bos taurus OX=9913 GN=LOC508459 PE=3 SV=1 CANONICAL=A0A3Q1M1E4-1" }, "locus": { "chromosome": "7", "start_pos": 17633111, "end_pos": 17558233, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154002.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154002.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104291.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104291.1" } ] } }, { "isoform_ac": "E1BNX3-1", "url": "https://www.uniprot.org/uniprotkb/E1BNX3/entry", "sequence": { "sequence": 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"ENSBTAP00000060699.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060699.2" } ] } }, { "isoform_ac": "A0A3Q1M3L9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L9/entry", "sequence": { "sequence": "MSAEGPPPPAARRGRPGRLQVSARTKTGIALLHDEVSGHAYDVRLKLTKEVLTIQKQDVICVSGSGPSANHRTVTLRRQPVGGLGLSIKGGVEHGVPVVISKIFRDLAADQTGMLFVGDALLQVNGINVESATHKEVVHLLKNAGDEVTVTVEYLREAPSFLKLPLGSPGPASQPGSGASSPLFDSGLHLNGASSNTAPSSPSSPVANKPKYEKRWLDALSLPLSMARVSRCRAGADTFRSSAIQVQALHGVSSGPLQFHTAQERADWLRMVSANISDLMLRNMKMANKCCSPCDQVIHMGWVSERLGGAGSSQTFRPRFLALRGSSLYVFISPPVSTLDWVRAEKTYHLCEVLFKVHKLWLPDDCWAQASLSLGLQDPDGGDHGPFCFSVLVGHSGSHVFSVELGSELAAWELSFQRATFRAVQRTRSKTYICSGQGDTLCFTVDFALGFTCFDSKTKSVLWRFKFSQLKGSSDDGKARVKLLFQSLDTKQIEMKELEFQDLTAVLHCIHSFMAARVASLDPAFMDTQSIARRYMYSS", "length": 539, "header": "tr|A0A3Q1M3L9-1|A0A3Q1M3L9_BOVIN Isoform 1 of Syntrophin gamma 2 OS=Bos taurus OX=9913 GN=SNTG2 PE=3 SV=2 CANONICAL=A0A3Q1M3L9-1" }, "locus": { "chromosome": "8", "start_pos": 112346315, "end_pos": 112226823, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077721.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077721.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064754.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064754.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9913351", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9913351", "resource": "Reactome", "description": "Formation of the dystrophin-glycoprotein complex (DGC)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "dystrophin-associated glycoprotein complex", "id": "GO:0016010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016010", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3L9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L9" } ], "pmid": "" }, { "name": "cytoplasm", "id": 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"name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3L9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L9" } ], "pmid": "" }, { "name": "PDZ domain binding", "id": "GO:0030165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030165", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3L9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L9" } ], "pmid": "" }, { "name": "neuroligin family protein binding", "id": "GO:0097109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097109", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3L9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M3L9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 539, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M3L9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M3L9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M3L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3L9" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 73, "end_pos": 156, "start_aa": "Thr", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 275, "end_pos": 277 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q9MZL5-1", "uniprot_ac": "Q9MZL5", "uniprot_id": "CACB2_BOVIN", "mass": { "chemical_mass": 67842.0, "monoisotopic_mass": 67842.0 }, "refseq": { "ac": "NP_786983", "name": "voltage-dependent L-type calcium channel subunit beta-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786983" }, "gene_names": [ { "name": "CACNB2", "type": "recommended", "evidence": [ { "id": "Q9MZL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZL5" } ] }, { "name": "CACNB2", "type": "synonym", "evidence": [ { "id": "NP_786983", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786983" } ] } ], "protein_names": [ { "name": "Voltage-dependent L-type calcium channel 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Plays a role in shifting voltage dependencies of activation and inactivation of the channel. May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (By similarity). 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"Protein Classification" ] }, { "id": "Q9MZL5", "url": "https://www.orthodb.org/?gene=Q9MZL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11824", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11824", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00625", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12052", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12052", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-112308", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112308", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-422356", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-422356", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5576892", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5576892", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5576893", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5576893", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_786983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786983", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVX8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVX8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA95", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA95", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA95-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA95-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBH6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBH6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MK14", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MK14-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZP0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZP0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2S9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2S9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2S9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2S9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5M7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5M7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9MZL5", "url": "https://www.uniprot.org/uniprotkb/Q9MZL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9MZL5-1", "url": "https://www.uniprot.org/uniprotkb/Q9MZL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQCCGLVHRRRARVSYGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEDNDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSTLPVSPTLASNSQGSQGDQRTDRGAPGRSASQAEEEHCPEPVKKAQHRSSTQHHNHRSGTSRGLSRQETLDSETQESRDSAYAEPKEEYSHEHADHYAPHRDHNHREEPHGGGEHRHREPRHRSRDPDREQDHNESNKQRSRHKSKDRYCDKDGEGLSRRRNEAADWNRDVYIRQ", "length": 603, "header": "sp|Q9MZL5-1|CACB2_BOVIN Isoform 1 of Voltage-dependent L-type calcium channel subunit beta-2 OS=Bos taurus OX=9913 GN=CACNB2 PE=2 SV=1 CANONICAL=Q9MZL5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVX8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVX8/entry", "sequence": { "sequence": "MKATWIRLLKRAKGGRLKNSDICGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEDNDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSTLPVSPTLASNSQGSQGDQRTDRGAPGRSASQAEEEHCPEPVKKAQHRSSTQHHNHRSGTSRGLSRQETLDSETQESRDSAYAEPKEEYSHEHADHYAPHRDHNHREEPHGGGEHRHREPRHRSRDPDREQDHNESNKQRSRHKSKDRYCDKDGEGLSRRRNEAADWNRDVYIRQ", "length": 610, "header": "tr|A0A3Q1LVX8-1|CACB2_BOVIN Computationally mapped isoform of Voltage-dependent L-type calcium channel subunit beta-2 OS=Bos taurus OX=9913 GN=CACNB2 PE=2 SV=1 CANONICAL=Q9MZL5-1" }, "locus": { "chromosome": "13", "start_pos": 32993618, "end_pos": 32864769, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082900.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082900.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061585.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061585.1" } ] } }, { "isoform_ac": "A0A3Q1MA95-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA95/entry", "sequence": { "sequence": "LLFCDSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEDNDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSTLPVSPTLASNSQGSQGDQRTDRGAPGRSASQAEEEHCPEPVKKAQHRSSTQHHNHRSGTSRGLSRQETLDSETQESRDSAYAEPKEEYSHEHADHYAPHRDHNHREEPHGGGEHRHREPRHRSRDPDREQDHNESNKQRSRHKSKDRYCDKDGEGLSRRRNEAADWNRDVYIRQ", "length": 588, "header": "tr|A0A3Q1MA95-1|CACB2_BOVIN Computationally mapped isoform of Voltage-dependent L-type calcium channel subunit beta-2 OS=Bos taurus OX=9913 GN=CACNB2 PE=2 SV=2 CANONICAL=Q9MZL5-1" }, "locus": { "chromosome": "13", "start_pos": 32993618, "end_pos": 32865370, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070047.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070047.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067519.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067519.2" } ] } }, { "isoform_ac": "A0A3Q1MBH6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBH6/entry", "sequence": { "sequence": "MYHNGSEHSHVGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEDNDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSTLPVSPTLASNSQGSQGDQRTDRGAPGRSASQAEEEHCPEPVKKAQHRSSTQHHNHRSGTSRGLSRQETLDSETQESRDSAYAEPKEEYSHEHADHYAPHRDHNHREEPHGGGEHRHREPRHRSRDPDREQDHNESNKQRSRHKSKDRYCDKDGEGLSRRRNEAADWNRDVYIRQ", "length": 598, "header": "tr|A0A3Q1MBH6-1|CACB2_BOVIN Computationally mapped isoform of Voltage-dependent L-type calcium channel subunit beta-2 OS=Bos taurus OX=9913 GN=CACNB2 PE=2 SV=2 CANONICAL=Q9MZL5-1" }, "locus": { "chromosome": "13", "start_pos": 32993618, "end_pos": 32823667, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072344.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072344.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066013.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066013.2" } ] } }, { "isoform_ac": "A0A3Q1MK14-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK14/entry", "sequence": { "sequence": "MLVKLLLATSALHVAMLKTPKGKNVSWGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEDNDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSTLPVSPTLASNSQGSQGDQRTDRGAPGRSASQAEEEHCPEPVKKAQHRSSTQHHNHRSGTSRGLSRQETLDSETQESRDSAYAEPKEEYSHEHADHYAPHRDHNHREEPHGGGEHRHREPRHRSRDPDREQDHNESNKQRSRHKSKDRYCDKDGEGLSRRRNEAADWNRDVYIRQ", "length": 614, "header": "tr|A0A3Q1MK14-1|CACB2_BOVIN Computationally mapped isoform of Voltage-dependent L-type calcium channel subunit beta-2 OS=Bos taurus OX=9913 GN=CACNB2 PE=2 SV=1 CANONICAL=Q9MZL5-1" }, "locus": { "chromosome": "13", "start_pos": 32993618, "end_pos": 32748148, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071974.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071974.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069538.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069538.1" } ] } }, { "isoform_ac": "A0AAA9RZP0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZP0/entry", "sequence": { "sequence": "MFDRRLMSPQTKCLLPGGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEDNDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSTLPVSPTLASNSQGSQGDQRTDRGAPGRSASQAEEEHCPEPVKKAQHRSSTQHHNHRSGTSRGLSRQETLDSETQESRDSAYAEPKEEYSHEHADHYAPHRDHNHREEPHGGGEHRHREPRHRSRDPDREQDHNESNKQRSRHKSKDRYCDKDGEGLSRRRNEAADWNRDVYIRQ", "length": 604, "header": "tr|A0AAA9RZP0-1|CACB2_BOVIN Computationally mapped isoform of Voltage-dependent L-type calcium channel subunit beta-2 OS=Bos taurus OX=9913 GN=CACNB2 PE=2 SV=1 CANONICAL=Q9MZL5-1" }, "locus": { "chromosome": "13", "start_pos": 32993618, "end_pos": 32794918, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122827.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122827.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078121.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078121.1" } ] } }, { "isoform_ac": "A0AAA9T2S9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2S9/entry", "sequence": { "sequence": "MKATWIRLLKRAKGGRLKNSDICGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAKQKQKSTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSTLPVSPTLASNSQGSQGDQRTDRGAPGRSASQAEEEHCPEPVKKAQHRSSTQHHNHRSGTSRGLSRQETLDSETQESRDSAYAEPKEEYSHEHADHYAPHRDHNHREEPHGGGEHRHREPRHRSRDPDREQDHNESNKQRSRHKSKDRYCDKDGEGLSRRRNEAADWNRDVYIRQ", "length": 572, "header": "tr|A0AAA9T2S9-1|CACB2_BOVIN Computationally mapped isoform of Voltage-dependent L-type calcium channel subunit beta-2 OS=Bos taurus OX=9913 GN=CACNB2 PE=2 SV=1 CANONICAL=Q9MZL5-1" }, "locus": { "chromosome": "13", "start_pos": 32993618, "end_pos": 32864769, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122055.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122055.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090944.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090944.1" } ] } }, { "isoform_ac": "A0AAA9T5M7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5M7/entry", "sequence": { "sequence": "MNQAGGLDLLKISYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEDNDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSTLPVSPTLASNSQGSQGDQRTDRGAPGRSASQAEEEHCPEPVKKAQHRSSTQHHNHRSGTSRGLSRQETLDSETQESRDSAYAEPKEEYSHEHADHYAPHRDHNHREEPHGGGEHRHREPRHRSRDPDREQDHNESNKQRSRHKSKDRYCDKDGEGLSRRRNEAADWNRDVYIRQ", "length": 630, "header": "tr|A0AAA9T5M7-1|CACB2_BOVIN Computationally mapped isoform of Voltage-dependent L-type calcium channel subunit beta-2 OS=Bos taurus OX=9913 GN=CACNB2 PE=2 SV=1 CANONICAL=Q9MZL5-1" }, "locus": { "chromosome": "13", "start_pos": 32993618, "end_pos": 32569290, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115334.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115334.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091867.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091867.1" } ] } }, { "isoform_ac": "A0AAA9TW09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW09/entry", "sequence": { "sequence": "MVQNDMSKSPPTAAAAVAQEIQMELLENAAPAGALGAAAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEDNDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSTLPVSPTLASNSQGSQGDQRTDRGAPGRSASQAEEEHCPEPVKKAQHRSSTQHHNHRSGTSRGLSRQETLDSETQESRDSAYAEPKEEYSHEHADHYAPHRDHNHREEPHGGGEHRHREPRHRSRDPDREQDHNESNKQRSRHKSKDRYCDKDGEGLSRRRNEAADWNRDVYIRQ", "length": 658, "header": "tr|A0AAA9TW09-1|CACB2_BOVIN Computationally mapped isoform of Voltage-dependent L-type calcium channel subunit beta-2 OS=Bos taurus OX=9913 GN=CACNB2 PE=2 SV=1 CANONICAL=Q9MZL5-1" }, "locus": { "chromosome": "13", "start_pos": 32993618, "end_pos": 32568798, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110321.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110321.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101362.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101362.1" } ] } }, { "isoform_ac": "Q9MZL5-1", "url": "https://www.uniprot.org/uniprotkb/Q9MZL5/entry#Q9MZL5-1", "sequence": { "sequence": "MQCCGLVHRRRARVSYGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEDNDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPLLSRTLATSTLPVSPTLASNSQGSQGDQRTDRGAPGRSASQAEEEHCPEPVKKAQHRSSTQHHNHRSGTSRGLSRQETLDSETQESRDSAYAEPKEEYSHEHADHYAPHRDHNHREEPHGGGEHRHREPRHRSRDPDREQDHNESNKQRSRHKSKDRYCDKDGEGLSRRRNEAADWNRDVYIRQ", "length": 603, "header": "sp|Q9MZL5-1|CACB2_BOVIN Isoform 1 of Voltage-dependent L-type calcium channel subunit beta-2 OS=Bos taurus OX=9913 GN=CACNB2 PE=2 SV=1 CANONICAL=Q9MZL5-1" }, "locus": { "chromosome": "13", "start_pos": 32993618, "end_pos": 32712265, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029344.4", "url": "https://www.ensembl.org/id/ENSBTAT00000029344.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029344.3", "url": "https://www.ensembl.org/id/ENSBTAP00000029344.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 149, "end_pos": 149, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9MZL5", "url": "https://www.uniprot.org/uniprotkb/Q9MZL5" } ], "site_lbl": "Ser149" }, { "start_pos": 152, "end_pos": 152, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9MZL5", "url": "https://www.uniprot.org/uniprotkb/Q9MZL5" } ], "site_lbl": "Ser152" }, { "start_pos": 163, "end_pos": 163, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9MZL5", "url": 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027289", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027289", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LX88", "url": "https://www.orthodb.org/?gene=A0A3Q1LX88", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZI4", "url": "https://www.orthodb.org/?gene=A0A3Q1LZI4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BC39", "url": "https://www.orthodb.org/?gene=E1BC39", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48092", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48092", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00104", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00104", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00105", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00105", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-383280", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LX88", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LX88-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXJ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZI4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZI4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP87-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNU3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNU3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXN8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXN8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC39", "url": "https://www.uniprot.org/uniprotkb/E1BC39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BC39-1", "url": "https://www.uniprot.org/uniprotkb/E1BC39-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPLLWSDPADNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV", "length": 465, "header": "tr|A0A3Q1LZI4-1|A0A3Q1LZI4_BOVIN Isoform 1 of Estrogen related receptor gamma OS=Bos taurus OX=9913 GN=ESRRG PE=3 SV=2 CANONICAL=A0A3Q1LZI4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LX88-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX88/entry", "sequence": { "sequence": "MGLLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV", "length": 441, "header": "tr|A0A3Q1LX88-1|A0A3Q1LZI4_BOVIN Computationally mapped isoform of Estrogen related receptor gamma OS=Bos taurus OX=9913 GN=ESRRG PE=3 SV=1 CANONICAL=A0A3Q1LZI4-1" }, "locus": { "chromosome": "16", "start_pos": 20139745, "end_pos": 19907217, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079548.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079548.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062093.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062093.1" } ] } }, { "isoform_ac": "A0A3Q1LXJ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXJ2/entry", "sequence": { "sequence": "MSGLLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV", "length": 442, "header": "tr|A0A3Q1LXJ2-1|A0A3Q1LZI4_BOVIN Computationally mapped isoform of Estrogen related receptor gamma OS=Bos taurus OX=9913 GN=ESRRG PE=3 SV=1 CANONICAL=A0A3Q1LZI4-1" }, "locus": { "chromosome": "16", "start_pos": 20102402, "end_pos": 19907217, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081580.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081580.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060246.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060246.2" } ] } }, { "isoform_ac": "A0A3Q1LZI4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZI4/entry", "sequence": { "sequence": "MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPLLWSDPADNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV", "length": 465, "header": "tr|A0A3Q1LZI4-1|A0A3Q1LZI4_BOVIN Isoform 1 of Estrogen related receptor gamma OS=Bos taurus OX=9913 GN=ESRRG PE=3 SV=2 CANONICAL=A0A3Q1LZI4-1" }, "locus": { "chromosome": "16", "start_pos": 20148492, "end_pos": 19907217, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074991.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074991.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063061.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063061.2" } ] } }, { "isoform_ac": "A0AAA9SP87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP87/entry", "sequence": { "sequence": "MRKYSTQLLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV", "length": 446, "header": "tr|A0AAA9SP87-1|A0A3Q1LZI4_BOVIN Computationally mapped isoform of Estrogen related receptor gamma OS=Bos taurus OX=9913 GN=ESRRG PE=3 SV=1 CANONICAL=A0A3Q1LZI4-1" }, "locus": { "chromosome": "16", "start_pos": 20149169, "end_pos": 19907217, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105319.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105319.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084706.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084706.1" } ] } }, { "isoform_ac": "A0AAA9TBV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBV0/entry", "sequence": { "sequence": "MSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV", "length": 396, "header": "tr|A0AAA9TBV0-1|A0A3Q1LZI4_BOVIN Computationally mapped isoform of Estrogen related receptor gamma OS=Bos taurus OX=9913 GN=ESRRG PE=3 SV=1 CANONICAL=A0A3Q1LZI4-1" }, "locus": { "chromosome": "16", "start_pos": 20100702, "end_pos": 19907217, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135196.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135196.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094332.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094332.1" } ] } }, { "isoform_ac": "A0AAA9TNU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNU3/entry", "sequence": { "sequence": "MLLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV", "length": 440, "header": "tr|A0AAA9TNU3-1|A0A3Q1LZI4_BOVIN Computationally mapped isoform of Estrogen related receptor gamma OS=Bos taurus OX=9913 GN=ESRRG PE=3 SV=1 CANONICAL=A0A3Q1LZI4-1" }, "locus": { "chromosome": "16", "start_pos": 20599311, "end_pos": 19907217, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135431.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135431.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098016.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098016.1" } ] } }, { "isoform_ac": "A0AAA9TXN8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXN8/entry", "sequence": { "sequence": "MPVIISLFCGLEEVILKYWLLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV", "length": 458, "header": "tr|A0AAA9TXN8-1|A0A3Q1LZI4_BOVIN Computationally mapped isoform of Estrogen related receptor gamma OS=Bos taurus OX=9913 GN=ESRRG PE=3 SV=1 CANONICAL=A0A3Q1LZI4-1" }, "locus": { "chromosome": "16", "start_pos": 20101482, "end_pos": 19907217, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135839.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135839.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101971.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101971.1" } ] } }, { "isoform_ac": "E1BC39-1", "url": "https://www.uniprot.org/uniprotkb/E1BC39/entry", "sequence": { "sequence": "MGPTKLLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV", "length": 444, "header": "tr|E1BC39-1|E1BC39_BOVIN Computationally mapped isoform of Estrogen related receptor gamma OS=Bos taurus OX=9913 GN=ESRRG PE=3 SV=4 CANONICAL=A0A3Q1LZI4-1" }, "locus": { "chromosome": "16", "start_pos": 20101807, "end_pos": 19907217, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061126.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061126.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053785.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053785.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 263, "start_aa": "Thr", "end_pos": 263, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr263", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-383280", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "resource": "Reactome", "description": "Nuclear Receptor transcription pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, 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Structure" ] }, { "id": "1G0W", "url": "https://www.rcsb.org/structure/1G0W", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00217", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00217", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02807", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02807", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-71288", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71288", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_777198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777198", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17157", "url": "https://www.rhea-db.org/rhea/17157", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LX97", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LX97-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX97-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9XSC6-1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPFGNTHNKHKLNFKAEEEYPDLSKHNNHMAKALTLEIYKKLRDKETPSGFTLDDVIQTGVDNPGHPFIMTVGCVAGDEESYTVFKDLFDPIIQDRHGGFKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYALPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK", "length": 381, "header": "sp|Q9XSC6-1|KCRM_BOVIN Isoform 1 of Creatine kinase M-type OS=Bos taurus OX=9913 GN=CKM PE=1 SV=2 CANONICAL=Q9XSC6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LX97-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX97/entry", "sequence": { "sequence": "MPSHAHLRAFAPAVPLPDTHMAGSLWSLHGCHLPREAPRTTATMPFGNTHNKHKLNFKAEEEYPDLSKHNNHMAKALTLEIYKKLRDKETPSGFTLDDVIQTGVDNPGHPFIMTVGCVAGDEESYTVFKDLFDPIIQDRHGGFKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYALPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK", "length": 424, "header": "tr|A0A3Q1LX97-1|KCRM_BOVIN Computationally mapped isoform of Creatine kinase M-type OS=Bos taurus OX=9913 GN=CKM PE=1 SV=2 CANONICAL=Q9XSC6-1" }, "locus": { "chromosome": "18", "start_pos": 52967663, "end_pos": 52956837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081515.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081515.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060135.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060135.2" } ] } }, { "isoform_ac": "Q9XSC6-1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6/entry#Q9XSC6-1", "sequence": { "sequence": "MPFGNTHNKHKLNFKAEEEYPDLSKHNNHMAKALTLEIYKKLRDKETPSGFTLDDVIQTGVDNPGHPFIMTVGCVAGDEESYTVFKDLFDPIIQDRHGGFKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYALPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK", "length": 381, "header": "sp|Q9XSC6-1|KCRM_BOVIN Isoform 1 of Creatine kinase M-type OS=Bos taurus OX=9913 GN=CKM PE=1 SV=2 CANONICAL=Q9XSC6-1" }, "locus": { "chromosome": "18", "start_pos": 52963534, "end_pos": 52956837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018492.4", "url": "https://www.ensembl.org/id/ENSBTAT00000018492.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018492.2", "url": "https://www.ensembl.org/id/ENSBTAP00000018492.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 164, "end_pos": 164, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "site_lbl": "Ser164" }, { "start_pos": 166, "end_pos": 166, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "site_lbl": "Thr166" }, { "start_pos": 178, "end_pos": 178, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "site_lbl": "Ser178" }, { "start_pos": 180, "end_pos": 180, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "site_lbl": "Thr180" }, { "start_pos": 199, "end_pos": 199, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "site_lbl": "Ser199" }, { "start_pos": 313, "end_pos": 313, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "site_lbl": "Thr313" }, { "start_pos": 322, "end_pos": 322, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "site_lbl": "Thr322" }, { "start_pos": 372, "end_pos": 372, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "site_lbl": "Ser372" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The three-dimensional structure of cytosolic bovine retinal creatine kinase.", "journal": "Acta Crystallogr. D", "date": "2001", "authors": "Tisi D, Bax B, Loew A", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "reference": [ { "type": "PubMed", "id": "11173463", "url": "https://glygen.org/publication/PubMed/11173463" } ] }, { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:286822", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286822", "resource": "KEGG Pathway" }, { "id": "R-BTA-71288", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71288", "resource": "Reactome", "description": "Creatine metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QZN6-1", "protein_name": "Creatine kinase M-type", "gene_name": "CKM", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPFGNTHNKYKLNFKAEEEYPDLSKHNNHMAKALTLEIYKKLRDKETPSGFTLDDVIQTGVDPGHPFIMTVGCVAGDEESYVVFKDLFDPIIQDRHGGYKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK", "length": 380 }, "evidence": [ { "id": "Q9XSC6", "url": "https://omabrowser.org/oma/group/Q9XSC6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A2BHA3-1", "protein_name": "creatine kinase", "gene_name": "ckma", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPFGNTHNNFKLNYSVDEEYPDLSKHNNHMAKVLTKEMYGKLRDKQTSTGFTVDDVIQTGVDNPGHPFIMTVGCVAGDEESYEVFKDLFDPVISDRHGGYKATDKHKTDLNFENLKGGDDLDPNYVLSSRVRTGRSIKGYALPPHNSRGERRAVEKLSVEALSSLDGEFKGKYYPLKSMTDAEQEQLIADHFLFDKPVSPLLLAAGMARDWPDARGIWHNENKTFLVWVNEEDHLRVISMQKGGNMKEVFKRFCVGLQRIEEIFKKHNHGFMWNEHLGFVLTCPSNLGTGLRGGVHVKLPKLSTHAKFEEILTRLRLQKRGTGGVDTASVGGVFDISNADRIGSSEVEQVQCVVDGVKLMVEMEKKLEKGESIDSMIPAQK", "length": 381 }, "evidence": [ { "id": "Q9XSC6", "url": "https://omabrowser.org/oma/group/Q9XSC6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P06732-1", "protein_name": "Creatine kinase M-type", "gene_name": "CKM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPFGNTHNKFKLNYKPEEEYPDLSKHNNHMAKVLTLELYKKLRDKETPSGFTVDDVIQTGVDNPGHPFIMTVGCVAGDEESYEVFKELFDPIISDRHGGYKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEKEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNQHLGYVLTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK", "length": 381 }, "evidence": [ { "id": "Q9XSC6", "url": "https://omabrowser.org/oma/group/Q9XSC6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "phosphocreatine biosynthetic process", "id": "GO:0046314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046314", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "pmid": "" }, { "name": "response to heat", "id": "GO:0009408", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009408", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "creatine kinase activity", "id": "GO:0004111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004111", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC6", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17157", "name": "", "equation": "creatine + ATP = N-phosphocreatine + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6ZIA4-1", "Q5EA61-1", "Q9TTK8-1", "Q9XSC6-1", "Q3ZBP1-1" ], "evidence": [ { "id": "17157", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17157" } ] }, { "id": "R-BTA-200318", "name": "creatine + ATP => phosphocreatine + ADP [CKB,CKM]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9XSC6-1", "Q5EA61-1" ], "evidence": [ { "id": "R-BTA-200318", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-200318" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6ZIA4", "gene_name": "CKB", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "A0AAF6ZIA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZIA4" } ] } ] }, { "uniprot_ac": "Q3ZBP1", "gene_name": "CKMT2", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q3ZBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q3ZBP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBP1" } ] } ] }, { "uniprot_ac": "Q5EA61", "gene_name": "CKB", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q5EA61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA61" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q5EA61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA61" } ] } ] }, { "uniprot_ac": "Q9TTK8", "gene_name": "CKMT1", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ] } ] }, { "uniprot_ac": "Q9XSC6", "gene_name": "CKM", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q9XSC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q9XSC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9XSC6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 381, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9XSC6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9XSC6" }, { "pdb_id": "1g0w", "pdb_chain": "a", "start_pos": 7, "end_pos": 359, "overlap": "1.0", "method": "X-Ray_Crystallography", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/1g0w.pdb", "url_external": "https://www.rcsb.org/structure/1g0w" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q9XSC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" }, { "id": "PRU00843", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00843" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosphagen kinase C-terminal", "eco_id": "ECO_0000255", "start_pos": 125, "end_pos": 367, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "Q9XSC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSC6" }, { "id": "PRU00842", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosphagen kinase N-terminal", "eco_id": "ECO_0000255", "start_pos": 11, 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"sequence": "MKRGNCSSLTEFILWGITDKPEVKMILFIMFVIVYLINLLANLGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLVDLLAKKRSISFCGCALQFLVFSNFIDCECLLLAVMAYDRYKAISSPLLYVVSMSSRLCSLLMAGVYLLGIIDTLIHTILAFRLCFCGSNVINHFFCDLPPLLSLSCSDTRVNELALFIFFGCVELTSISGVLVSYCYIILAVLKIHSAEGRFRAFSTCTSHLTAVAIFQGTVFFMYFRPSSSYSLDEDKMSSLFYTLVIPMLNPLIYSLRNKDVKQALQKLKL", "length": 306, "header": "tr|A0A3Q1LXL3-1|A0A3Q1LXL3_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5W26 PE=3 SV=1 CANONICAL=A0A3Q1LXL3-1" }, "locus": { "chromosome": "15", "start_pos": 78515560, "end_pos": 78514643, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066812.1", "url": "https://www.ensembl.org/id/ENSBTAT00000066812.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062242.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062242.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520162", "name": "", "url": 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"evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXL3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL3" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXL3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL3" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXL3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXL3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXL3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL3" } ], "pmid": "" }, { "name": "sensory perception of smell", "id": "GO:0007608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007608", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXL3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LXL3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 306, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": 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"section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", 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"total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LXL8-1", "uniprot_ac": "A0A3Q1LXL8", "uniprot_id": "A0A3Q1LXL8_BOVIN", "mass": { "chemical_mass": 51206.0, "monoisotopic_mass": 51206.0 }, "refseq": {}, "gene_names": [ { "name": "MTX1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LXL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8" } ] } ], "protein_names": [ { "name": "Metaxin-1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LXL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8/entry#names_and_taxonomy" } ] }, { "name": "Mitochondrial outer membrane import complex protein 1", "type": "synonym", "evidence": [ { "id": "A0A3Q1LXL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in transport of proteins into the mitochondrion. Essential for embryonic development.", "evidence": [ { "database": "UniProtKB", "id": "F1N1D6", "url": "https://www.uniprot.org/uniprotkb/F1N1D6#function" }, { "database": "UniProtKB", "id": "ARBA00037753", "url": "https://www.uniprot.org/uniprotkb/ARBA00037753#function" }, { "database": "UniProtKB", "id": "A0A3Q1LXL8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXL8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTX1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8", "locus": { "chromosome": "3", "start_pos": 15409500, "end_pos": 15414667, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014840", "url": "https://www.ensembl.org/id/ENSBTAG00000014840" } ] } } ], "crossref": [ { "id": "A0A3Q1LXL8", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LXL8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014840", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014840", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03078", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03078", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03212", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03212", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR019564", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019564", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033468", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033468", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050931", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050931", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PIPFNFY", "url": "https://omabrowser.org/oma/group/PIPFNFY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXL8", "url": "https://www.orthodb.org/?gene=A0A3Q1LXL8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N1D6", "url": "https://www.orthodb.org/?gene=F1N1D6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12289", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12289", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12289:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12289:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10568", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10568", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17171", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17171", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9013404", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LXL8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXL8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1D6", "url": "https://www.uniprot.org/uniprotkb/F1N1D6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1D6-1", "url": "https://www.uniprot.org/uniprotkb/F1N1D6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLGGPPRSPRSGPSPEGPQSSPDVLQICEGPQNPSWSTKSPSLAPTASSGVQGSPPSGLPDSPRRAGLRIHPPFGRHLWIRRRPPCPEALGSAPRRFQAASRAWTSRALLTASPGSRARSAEREGGGSTQRRAEAQGEVLPGQRAGKMAAPMELFCWSGGWGLPSVDLDSLAVLTYARFTGAPLKVHKITNPWRSPSGTLPALRTSHGEVISVPHRIITHLRKEKYNADYDLSARQGADTLAFMSLLEEKLLPVLIHTFWIDAKNYVEVTRKWYAEAMPFPLNFFLPGRMQRQYMERLQLLCGEHRPEDEEELEKELYQEAQECLTLLSQRLGSQKFFFGDAPASLDAFVFSYLALLQQAKLPSGKLQAHLRGLHNLCAYCAHILSLYFPWEGAKAPPPRQTPANPETEEEPYRRRNQILTVLAGLAAMAGYALLSGIVSIQRAPSARAPGTQALGMAEEDEEE", "length": 465, "header": "tr|A0A3Q1LXL8-1|A0A3Q1LXL8_BOVIN Isoform 1 of Metaxin-1 OS=Bos taurus OX=9913 GN=MTX1 PE=3 SV=1 CANONICAL=A0A3Q1LXL8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXL8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8/entry", "sequence": { "sequence": "MRLGGPPRSPRSGPSPEGPQSSPDVLQICEGPQNPSWSTKSPSLAPTASSGVQGSPPSGLPDSPRRAGLRIHPPFGRHLWIRRRPPCPEALGSAPRRFQAASRAWTSRALLTASPGSRARSAEREGGGSTQRRAEAQGEVLPGQRAGKMAAPMELFCWSGGWGLPSVDLDSLAVLTYARFTGAPLKVHKITNPWRSPSGTLPALRTSHGEVISVPHRIITHLRKEKYNADYDLSARQGADTLAFMSLLEEKLLPVLIHTFWIDAKNYVEVTRKWYAEAMPFPLNFFLPGRMQRQYMERLQLLCGEHRPEDEEELEKELYQEAQECLTLLSQRLGSQKFFFGDAPASLDAFVFSYLALLQQAKLPSGKLQAHLRGLHNLCAYCAHILSLYFPWEGAKAPPPRQTPANPETEEEPYRRRNQILTVLAGLAAMAGYALLSGIVSIQRAPSARAPGTQALGMAEEDEEE", "length": 465, "header": "tr|A0A3Q1LXL8-1|A0A3Q1LXL8_BOVIN Isoform 1 of Metaxin-1 OS=Bos taurus OX=9913 GN=MTX1 PE=3 SV=1 CANONICAL=A0A3Q1LXL8-1" }, "locus": { "chromosome": "3", "start_pos": 15414468, "end_pos": 15409629, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067601.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067601.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061957.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061957.1" } ] } }, { "isoform_ac": "F1N1D6-1", "url": "https://www.uniprot.org/uniprotkb/F1N1D6/entry", "sequence": { "sequence": "MPDLLVPHSRCTRSPTPGGVLQELCLPFGPVMERSSQYHTGSSPTFEKRWRNWGINGGLRGMERRDPEVQCGLRPVSPPRSRHLGLHVLAGGEAAPSADAKNYVEVTRKWYAEAMPFPLNFFLPGRMQRQYMERLQLLCGEHRPEDEEELEKELYQEAQECLTLLSQRLGSQKFFFGDAPASLDAFVFSYLALLQQAKLPSGKLQAHLRGLHNLCAYCAHILSLYFPWEGAKAPPPRQTPANPETEEEPYRRRNQILTVLAGLAAMAGYALLSGIVSIQRAPSARAPGTQALGMAEEDEEE", "length": 301, "header": "tr|F1N1D6-1|A0A3Q1LXL8_BOVIN Computationally mapped isoform of Metaxin-1 OS=Bos taurus OX=9913 GN=MTX1 PE=3 SV=4 CANONICAL=A0A3Q1LXL8-1" }, "locus": { "chromosome": "3", "start_pos": 15412965, "end_pos": 15409629, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019763.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019763.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019763.7", "url": "https://www.ensembl.org/id/ENSBTAP00000019763.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9013404", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "resource": "Reactome", "description": "RAC2 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JU49-1", "protein_name": "Metaxin-1", "gene_name": "Mtx1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRLGGPPRNVRSGQRFERSRCSRGHVQFGKSPQRPLSRTRCPSSKPCLSPAVRGYARQRHRESPKRAWTAALLPYGGRLRTSPRRSSEGQCSTSSSAAASPAARSHASLDLKLRVATQAETRGCSSWREKADAYERVLPGQRMCKMAAPMELFCWSGGWGLPSVDLDSLAVLTYTRFTCAPLKVHKISNPWQSPSDLFNIFSILGTLPALRTSSGKVITEPHKIITHLRKEKYNADYDLSARQGADTLAFISLLEEKLLPMLIHTFWIDAKNYVEVTRKWYAEAMPFPLNFFLPGRMQRRHMERLQLLCGEHRLESEEELEKELYQEARECLTLLSHRLGSRKFFFGDAPASLDAFVFSHLVLLLQAKLPSGKLQAHLRGLQNLCVYCTHILNLYFPRDATDVPPPPCQTPAGPETEEEPYRRRTQILSVLAGLAAMVGYALLSGIVSIQRASPARAPCTQALDLAEEDEED", "length": 472 }, "evidence": [ { "id": "A0A3Q1LXL8", "url": "https://omabrowser.org/oma/group/A0A3Q1LXL8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P47802-1", "protein_name": "Metaxin-1", "gene_name": "Mtx1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAPMELFCWSGGWGLPSVDLDSLAVLTYTRFTGAPLKIHKTSNPWQSPSGTLPALRTSDGKVITVPDKIITHLRKEKYNADYDLSARQGADTLAFMSLLEEKLLPVLIHTFWIDAKNYVEVTRKWYAEAMPFPLNFFLPGRMQRQYMERLQLLCGEHKSENEEELEKELYQEARECLTLLSQRLGSQKFFFGDAPASLDAFVFSHLALLLQAKLPSGKLQAHLRGLHNLCAYCTHILNLYFPRDGDEVPLPRQTPAAPETEEEPYRRRTQILSVLAGLAAMVGYALLSGIVSIQRTSPARAPGTRALGLAEEDEED", "length": 317 }, "evidence": [ { "id": "A0A3Q1LXL8", "url": "https://omabrowser.org/oma/group/A0A3Q1LXL8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q13505-1", "protein_name": "Metaxin-1", "gene_name": "MTX1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLGGPPRSPRSGTSPKGPWSSTGHVQFGKSPQTWPRRTRPRSPEPAAPSGVRGSTWTRRRDSPRRAGPTALSRYVGHLWMGRRPPSPEARGPVPRSSAASRARRSLASPGISPGPLTATIGGAVAGGGPRQGRAEAHKEVFPGQRVGKMAAPMELFCWSGGWGLPSVDLDSLAVLTYARFTGAPLKVHKISNPWQSPSGTLPALRTSHGEVISVPHKIITHLRKEKYNADYDLSARQGADTLAFMSLLEEKLLPVLVHTFWIDTKNYVEVTRKWYAEAMPFPLNFFLPGRMQRQYMERLQLLTGEHRPEDEEELEKELYREARECLTLLSQRLGSQKFFFGDAPASLDAFVFSYLALLLQAKLPSGKLQVHLRGLHNLCAYCTHILSLYFPWDGAEVPPQRQTPAGPETEEEPYRRRNQILSVLAGLAAMVGYALLSGIVSIQRATPARAPGTRTLGMAEEDEEE", "length": 466 }, "evidence": [ { "id": "A0A3Q1LXL8", "url": "https://omabrowser.org/oma/group/A0A3Q1LXL8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q27HK4-1", "protein_name": "Metaxin-1", "gene_name": "MTX1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAPMELFCWSGGWGLPSVDLDSLAVLTYARFTGAPLKVHKITNPWRSPSGTLPALRTSQGEVISVPHKIITHLRKEKYNADYDLSARQGADTLAFMSLLEEKLLPVLIHTFWVDAKNYVEVTRKWYAEAMPFPLNFFLPGRMQRQYMERLQLLCGEHRPEEEEELEKELYQEARECLTLLSQRLGAQKFFFGDAPASLDAFVFSYLALLQQAKLPSGKLQAHLRGLHNLCAYCTHILSLYFPWEGAEVPRPRQTPASSETEEEPYRRRNQILSVLAGLAAMAGYALLSGIVSIQRAPPARAPSTRALGMAEEDEEE", "length": 317 }, "evidence": [ { "id": "A0A3Q1LXL8", "url": "https://omabrowser.org/oma/group/A0A3Q1LXL8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "SAM complex", "id": "GO:0001401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001401", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXL8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein insertion into mitochondrial outer membrane", "id": "GO:0045040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045040", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXL8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXL8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8" } ], "pmid": "" }, { "name": "mitochondrial outer membrane translocase complex assembly", "id": "GO:0070096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070096", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXL8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LXL8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 465, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LXL8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LXL8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LXL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8" }, { "id": "PF17171", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17171" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Metaxin glutathione S-transferase", "eco_id": "ECO_0000259", "start_pos": 322, "end_pos": 385, "start_aa": "Ala", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LXL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXL8" }, { "id": "PF10568", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10568" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal", "eco_id": "ECO_0000259", "start_pos": 171, "end_pos": 292, "start_aa": "Ser", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LXS9-1", "uniprot_ac": "A0A3Q1LXS9", "uniprot_id": "A0A3Q1LXS9_BOVIN", "mass": { "chemical_mass": 75971.0, "monoisotopic_mass": 75971.0 }, "refseq": {}, "gene_names": [ { "name": "WDR70", "type": "recommended", "evidence": [ { "id": "A0A3Q1LXS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS9" } ] } ], "protein_names": [ { "name": "WD repeat-containing protein 70", "type": "recommended", "evidence": [ { "id": "A0A3Q1LXS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS9", "locus": { "chromosome": "20", "start_pos": 36690359, "end_pos": 36974107, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033095", "url": "https://www.ensembl.org/id/ENSBTAG00000033095" } ] } } ], "crossref": [ { "id": "A0A3Q1LXS9", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LXS9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033095", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033095", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KGDQYIT", "url": "https://omabrowser.org/oma/group/KGDQYIT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXS9", "url": "https://www.orthodb.org/?gene=A0A3Q1LXS9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCF1", "url": "https://www.orthodb.org/?gene=A0A3Q1MCF1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MXI9", "url": "https://www.orthodb.org/?gene=F1MXI9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16017", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16017", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16017:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16017:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LXS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXS9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCF1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MXI9", "url": "https://www.uniprot.org/uniprotkb/F1MXI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MXI9-1", "url": "https://www.uniprot.org/uniprotkb/F1MXI9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRETRVRSLGREDPAEKEMATPSSTLAWRIPRMEETGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREREEEMNREKELRRQNEDLEPTSSGSNVARACSKSSSRDTSSSESDESSDSSDDELIGPPLPLKMVEEPVNPMEEGVLGPLPPPLAEDVEEEDDDDGDSEEEENPVRKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVIPTTCTYSRDGSLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDPGTDTSCVTFSYDGTVLASRGGDDTLKLWDIRQFNKPLFSASGLPTMFPMTDCCFSPDDKLIVTGTSVQRGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDNPYWVSPAYSKTQPKTMFAQVESDDEETKNEPEWKKRKI", "length": 680, "header": "tr|A0A3Q1LXS9-1|A0A3Q1LXS9_BOVIN Isoform 1 of WD repeat-containing protein 70 OS=Bos taurus OX=9913 GN=WDR70 PE=3 SV=2 CANONICAL=A0A3Q1LXS9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXS9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS9/entry", "sequence": { "sequence": "MRETRVRSLGREDPAEKEMATPSSTLAWRIPRMEETGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREREEEMNREKELRRQNEDLEPTSSGSNVARACSKSSSRDTSSSESDESSDSSDDELIGPPLPLKMVEEPVNPMEEGVLGPLPPPLAEDVEEEDDDDGDSEEEENPVRKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVIPTTCTYSRDGSLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDPGTDTSCVTFSYDGTVLASRGGDDTLKLWDIRQFNKPLFSASGLPTMFPMTDCCFSPDDKLIVTGTSVQRGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDNPYWVSPAYSKTQPKTMFAQVESDDEETKNEPEWKKRKI", "length": 680, "header": "tr|A0A3Q1LXS9-1|A0A3Q1LXS9_BOVIN Isoform 1 of WD repeat-containing protein 70 OS=Bos taurus OX=9913 GN=WDR70 PE=3 SV=2 CANONICAL=A0A3Q1LXS9-1" }, "locus": { "chromosome": "20", "start_pos": 36969311, "end_pos": 36690448, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070504.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070504.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062321.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062321.2" } ] } }, { "isoform_ac": "A0A3Q1MCF1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCF1/entry", "sequence": { "sequence": "MSRIRHLMKALTSRLSRLMPEAREREEEMNREKELRRQNEDLEPTSSGSNVARACSKSSSRDTSSSESDESSDSSDDELIGPPLPLKMVEEPVNPMEEGVLGPLPPPLAEDVEEEDDDDGDSEEEENPVRKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVIPTTCTYSRDGSLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDPGTDTSCVTFSYDGTVLASRGGDDTLKLWDIRQFNKPLFSASGLPTMFPMTDCCFSPDDKLIVTGTSVQRGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDNPYWVSPAYSKTQPKTMFAQVESDDEETKNEPEWKKRKI", "length": 616, "header": "tr|A0A3Q1MCF1-1|A0A3Q1LXS9_BOVIN Computationally mapped isoform of WD repeat-containing protein 70 OS=Bos taurus OX=9913 GN=WDR70 PE=3 SV=2 CANONICAL=A0A3Q1LXS9-1" }, "locus": { "chromosome": "20", "start_pos": 36963241, "end_pos": 36690448, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074472.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074472.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068018.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068018.2" } ] } }, { "isoform_ac": "F1MXI9-1", "url": "https://www.uniprot.org/uniprotkb/F1MXI9/entry", "sequence": { "sequence": "MERPGPSDGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREREEEMNREKELRRQNEDLEPTSSGSNVARACSKSSSRDTSSSESDESSDSSDDELIGPPLPLKMVEEPVNPMEEGVLGPLPPPLAEDVEEEDDDDGDSEEEENPVRKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVIPTTCTYSRDGSLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDPGTDTSCVTFSYDGTVLASRGGDDTLKLWDIRQFNKPLFSASGLPTMFPMTDCCFSPDDKLIVTGTSVQRGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDNPYWVSPAYSKTQPKTMFAQVESDDEETKNEPEWKKRKI", "length": 652, "header": "tr|F1MXI9-1|A0A3Q1LXS9_BOVIN Computationally mapped isoform of WD repeat-containing protein 70 OS=Bos taurus OX=9913 GN=WDR70 PE=3 SV=3 CANONICAL=A0A3Q1LXS9-1" }, "locus": { "chromosome": "20", "start_pos": 36968839, "end_pos": 36690448, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046986.3", "url": "https://www.ensembl.org/id/ENSBTAT00000046986.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044228.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044228.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q3TWF6-1", "protein_name": "WD repeat-containing protein 70", "gene_name": "Wdr70", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEHSGTSEVTGADTAGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREKEEEMNREKELRKQIEDMEPAPSSSSAARERSQSSCRDTSSSDSESDDSSDSSDDELIGPPLPPKMVGESVTTVDEGTLGPLPPPLCEEGEDDDDDELDDEGEEDNPVQRIPDSHEITLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTDSWHPKIKGEFMTCSNDATVRLWEVENPKKQKSVFKPRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWDRNLTVHPKFHYKQAHDPGTDTSCVAFSYDGNVLASRGGDDTLKLWDVRQFNKPLFSASDLPTLFPMTDCCFSPDDKLIVTGTSVQRGCGSGKLVFLERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDNPYWVSPAYSKTQPKTMFAQVESDDEESKNEPEWKKRKI", "length": 657 }, "evidence": [ { "id": "A0A3Q1LXS9", "url": "https://omabrowser.org/oma/group/A0A3Q1LXS9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54R56-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNSTNNSQKREREDNEDINNIDSKLKKTETEADKEFKPPSLFSKNEDNDNIAFKSNFKPPSKPSAKPSFGGISFNITTKVLPPQQQQQQPTIINNNNDNESHEEKESINNSNNVNNDNNNNNNSSSSKTATTGPIKPTTTTNTVGPQKPTNTVGPTRPTKMDDDDSSDSSDSSDDENDDKNKIQQVSTTTKNNIGPQKPTTTTTNVGPQKPTTTTNVGPQKPTTNNVGPQKPSTTNVGPQKPTTNTIGPQRPTIKDDDDSDSDSDSDSDDDNSNKIKNEQQGIVGPTRPIMKKDDSSDSDDDDDSDDDSDDDEKEEIERWRQLAISLPISHEVTIKGHARTVSSISIDPSGSRMLSGSYDCKVKFWDFNGMDSSFRSFREIEPSEGTQVRSIQFSNLGDIFSALPYTTQIRIYDRDGHFKNESVSGDRFIQDLYHTKGHVSTLTAQCWHPTERDELISSSIDGTIRVWDVNQLSKNKSVIKSKNQKGSRVGVSNCCFDQRGDLVTGGMSDGTIAQWDKRSTLLKPKFTFQDAHEFGTQVTSIQYNRDCYSMISRGMDSTLRVWDLRNPLKPLVVWDDLLCDYIETNTIFGSYDRVIVTGTSAPKGGFGSIVIYDLSSLTKMRQIRVDNDVSVVNCHWSTKLNQIFFGCSDSSIRGFYDPTQSVNGLKLCASKAPRVKNVADFEPDRPIITPNTLPLFRQTNSKKEKKSQKINPSKEQLKSTTYTSNSTMKHLVSKIGIINNTSWKEDARESFLRVANKKEQQQQEQQKEEKK", "length": 772 }, "evidence": [ { "id": "A0A3Q1LXS9", "url": "https://omabrowser.org/oma/group/A0A3Q1LXS9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5EB92-1", "protein_name": "WD repeat-containing protein 70", "gene_name": "Wdr70", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEHSGPSEVTGADTAGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREKEEEMNREKELRKQLEDIEPTPSSSSAVRERSKSSSRDTSSSDSDHSSGSSDDELIGPPLPPEMVGGPVNTVDEDILGPLPPPLCEEGEDDDDDDLEDEGEEDNPIHRIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRLWEVENPKKQKSVFKPRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWDRNLTVHPKFHYKQAHAPGTDTSCVAFSYDGNVLASRGGDDTLKLWDVRQFNKPLFSASDLPTLFPMTDCCFSPDDKLIVTGTSVQRGCGSGKLVFFERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDNPYWVSPAYSKTQPKTMFAQVESDDEESKNEPEWKKRKI", "length": 655 }, "evidence": [ { "id": "A0A3Q1LXS9", "url": "https://omabrowser.org/oma/group/A0A3Q1LXS9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NW82-1", "protein_name": "WD repeat-containing protein 70", "gene_name": "WDR70", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERSGPSEVTGSDASGPDPQLAVTMGFTGFGKKARTFDLEAMFEQTRRTAVERSRKTLEAREKEEEMNREKELRRQNEDIEPTSSRSNVVRDCSKSSSRDTSSSESEQSSDSSDDELIGPPLPPKMVGKPVNFMEEDILGPLPPPLNEEEEEAEEEEEEEEEEENPVHKIPDSHEITLKHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMDASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKPRTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDSGTDTSCVTFSYDGNVLASRGGDDSLKLWDIRQFNKPLFSASGLPTMFPMTDCCFSPDDKLIVTGTSIQRGCGSGKLVFFERRTFQRVYEIDITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQRGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHKPEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDSPYWVSPAYSKTQPKTMFAQVESDDEEAKNEPEWKKRKI", "length": 654 }, "evidence": [ { "id": "A0A3Q1LXS9", "url": "https://omabrowser.org/oma/group/A0A3Q1LXS9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9SK69-1", "protein_name": "Transducin/WD40 repeat-like superfamily protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEDELEGLRAHFPVSFGKTSKVSASTEAIHSATRRTDVANDAGVSSDITTKKPDSDKSGFPSLSSSSQTWLRSVRGPNRNPNSSGDVAMGPPPPPSSKRTQEEEEEDEEVMMGPPPPPKGLGNINDSDDEGDMIGPPPPPPAARDSDEDSDDDDDNDNEENRYQIPLSNEIQLKGHTKIVSSLAVDSAGARVLSGSYDYTVRMYDFQGMNSRLQSFRQIEPSEGHQVRSVSWSPTSGQFLCVTGSAQAKIFDRDGLTLGEFMKGDMYIRDLKNTKGHICGLTCGEWHPRTKETVLTSSEDGSLRIWDVNNFLSQTQVIKPKLARPGRVPVTTCAWDRDGKRIAGGVGDGSIQIWSLKPGWGSRPDIYVGKAHTDDITSVKFSSDGRILLSRSFDGSLKVWDLRQMKEALKVFEGLPNYYPQTNVAFSPDEQIILTGTSVEKDSTTGGLLCFYDRTKLEIVQKVGISPTSSVVQCAWHPRLNQIFATSGDKSQGGTHILYDPSQSERGACVCVARAPRKKSVDDYQPEPVIHNPHALPLFRDAPSRKREREKALKDPMKSHKPEIPMTGPGHGGRVGTTGSGLLTQYLLKQGGMIKETWMEEDPREAILKYAEVAVKDPKFIAPAYSQTQPKTIFAKSDDEEEEGDTKK", "length": 648 }, "evidence": [ { "id": "A0A3Q1LXS9", "url": "https://omabrowser.org/oma/group/A0A3Q1LXS9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9W1J3-1", "protein_name": "Gastrulation defective protein 1 homolog", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQRGKISFGKIKLNVNVPPAEPRSNETEAEDAKESTEASGNGGGFKKMDKEQMIRQIEDVAEDLESQHLKEVMGISGFGRKAAKVFDINEQIEKARVTRPGMDKKREESKPKEDDQKDEEEEDVIGPLPPAVTTDKEKATKESSKDEDSDDDDYSSDEDSDDEQSLAKRIPYTHEVQMQHGSRAVLALAGDPSGARLVSGSIDYDMCFWDFAGMDSSMRSFRQLQPCENHPIRSLQYSVTGDMILVISGNAQAKVLDRDGFEKLECCKGDQYISDMSRTKGHVAQLTSGCWHPFNREQFLTAALDGTLRIWQGLKSKEQLQVIKTRAQGGLRTNAASCNFNRDATLIAAGCVDGSIQTWDTRKMFVNTTHCVRDAHQKGSEITSIVFSYMGQQLATRSNDETMKLWDLRQFKQPLHTWTNLFSRYDTTDCCFSPDDRLLVTGESLPKGQAEANLYFYSTKSYEEVQRIPVSNAHVVKTLWHPKLNQLFVSCGNGTIKCYYDEHRSIRGAKLCVVKTHRKRQPMEMVGVSQIITPHALPLFRQEKSRTSRKRMEKARMDPVKSQRPDLPITSGQGGRVASSGGTLSSYVIRNLGLSKRVDDDQDPREAILKYAKDAAENPYWIAPAYKQTQPKAIFSEKLPADEPATKKPKTEADK", "length": 655 }, "evidence": [ { "id": "A0A3Q1LXS9", "url": "https://omabrowser.org/oma/group/A0A3Q1LXS9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS9" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXS9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 379, "end_pos": 381, "annotation": "n_glycosylation_sequon" }, { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 528, "end_pos": 530, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LXS9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 680, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LXS9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LXS9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 379, "end_pos": 381 }, { "start_pos": 388, "end_pos": 390 }, { "start_pos": 528, "end_pos": 530 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LXZ2-1", "uniprot_ac": "A0A3Q1LXZ2", "uniprot_id": "A0A3Q1LXZ2_BOVIN", "mass": { "chemical_mass": 145879.0, "monoisotopic_mass": 145879.0 }, "refseq": { "ac": "XP_024844831", "name": "ATP-binding cassette sub-family C member 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844831" }, "gene_names": [ { "name": "LOC521568", "type": "recommended", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "name": "LOC521568", "type": "synonym", "evidence": [ { "id": "XP_024844831", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844831" } ] } ], "protein_names": [ { "name": "Multidrug resistance-associated protein 4", "type": "recommended", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.2", "type": "synonym", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.3", "type": "synonym", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2/entry#names_and_taxonomy" } ] }, { "name": "ATP-binding cassette sub-family C member 4", "type": "synonym", "evidence": [ { "id": "XP_024844831", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844831" } ] } ], "function": [ { "annotation": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotic molecules. Confers resistance to anticancer agents such as methotrexate.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2#function" }, { "database": "UniProtKB", "id": "ARBA00094206", "url": "https://www.uniprot.org/uniprotkb/ARBA00094206#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC521568", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2", "locus": {} } ], "crossref": [ { "id": "A0A3Q1LXZ2", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LXZ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054008", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054008", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03244", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03244", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03250", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03250", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18593", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18601", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18601", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521568", "url": "https://www.ncbi.nlm.nih.gov/gene/521568", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030240", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030240", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521568", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521568", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LXZ2", "url": "https://www.orthodb.org/?gene=A0A3Q1LXZ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24223", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24223:SF357", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24223:SF357", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00664", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00664", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024844831", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024844831", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "66424", "url": "https://www.rhea-db.org/rhea/66424", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LXZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLAVSPEVKTNPLQKANFCSRLFVWWLNPLFKIGHKRKLEPDDMYSVLPEDRSQHLGKELQRHWDQEVKRAQKDAQEPSLMKAVIKCYWKSYLIWGMFTFLEEGTRVVQPIFLGKMISYVENSNSVTLHEAYCYSAGLSACVLMWAVLHHLYFYHMQRVGMRLRVALCHMIYRKALRLSSPAMGKTTTGQIVNLLSNDVNRFDQVTMFLHYLWVGPLQAVTVTALLWMEIGISCLAGMAVLIILLLFQSCFGKLFSSLRSETSALTDKRIRTMNEIITGIRTIKMNAWEKSFIDLITRLRSKEISKILKSSYLRGLNLASFFTVSKIMIFVTFITNELLDNWIIASQVFVVVMLFEALRFLSTLYFPMAVEKVSEAVISLRRIKNFLSLDEIPQLNTQLPSDGEMMVDMQDFTAFWDEELDSPTLKGISFTVRLGELLTVVGPVGAGKSSLLRALLGELPPSQGKVSVHGRIAYVSQQPWVFPGTVRSNILFGKKYEEERYEEVIKVCALEEDLQNLKEKDLTVIGDGGTPLSEGQKARVSLARAVYQDADIYLLDDPLSAVDPRVSRHLFEQCIRQALKEKITILVTHQLQYLKDASQILILKDDKTVERGTYSEFLKSGVDIFSPFEKGNKQPASSPVLGTPTLMSESLVQSLPSPRPSLKDAAPEDQDIENIQVTLPLEDYLEGKVGFKTYKSYFTAGAGWPVITFLILVNIAAQVAYILQDWWLAFWANVQSDLYSGALIKEDVDTMIILNWCLRVYSGLTVSTIVFGITRSLLIIYILVNSSQTWHNKILESILRASVLFFNSNPIGRILNRFSKDIGHMDDLLPLIFLDFIQAFLLVIGVVGVMVAVIPWIAIPVIPLGIAFFFLQRYFSETSRDIKRLECATRSPVFSHLASSLRGLWTIRAYKAEQSFQELFDAHQDLHSEAWFLLLTTSRWLAVYLDVICAIFVTVVAFGALILAHALTPGQVGLVLSLALTLTGMFQWCIRQRTEVENLMISVERVMGYLDLEKEAPWEYKDHPPPPWSNEGRMHFYTVNFRHTSDGPLVLKNLSAVIESTKKVGIVGRTGAGKSSIFSAVFRLSEFEGLLSVDSCWIQATGLHNLRKKMSIILQEPVLFMETMRKNLDPFNEHTDKELWNALKEVQLKETIEGLPGKMDTALAETGANLSVGQRQLVCLARVILKKNQILIIDKATSNVDPRTDELIKKAIHEKFAQCTVITITHRLSTIIDSDMIMVLDSGTVKEYSPPHVLLQNSKSLFYKMVQQLGEAEATALTERAKQAHTKKK", "length": 1289, "header": "tr|A0A3Q1LXZ2-1|A0A3Q1LXZ2_BOVIN Isoform 1 of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC521568 PE=3 SV=2 CANONICAL=A0A3Q1LXZ2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2/entry", "sequence": { "sequence": "MLAVSPEVKTNPLQKANFCSRLFVWWLNPLFKIGHKRKLEPDDMYSVLPEDRSQHLGKELQRHWDQEVKRAQKDAQEPSLMKAVIKCYWKSYLIWGMFTFLEEGTRVVQPIFLGKMISYVENSNSVTLHEAYCYSAGLSACVLMWAVLHHLYFYHMQRVGMRLRVALCHMIYRKALRLSSPAMGKTTTGQIVNLLSNDVNRFDQVTMFLHYLWVGPLQAVTVTALLWMEIGISCLAGMAVLIILLLFQSCFGKLFSSLRSETSALTDKRIRTMNEIITGIRTIKMNAWEKSFIDLITRLRSKEISKILKSSYLRGLNLASFFTVSKIMIFVTFITNELLDNWIIASQVFVVVMLFEALRFLSTLYFPMAVEKVSEAVISLRRIKNFLSLDEIPQLNTQLPSDGEMMVDMQDFTAFWDEELDSPTLKGISFTVRLGELLTVVGPVGAGKSSLLRALLGELPPSQGKVSVHGRIAYVSQQPWVFPGTVRSNILFGKKYEEERYEEVIKVCALEEDLQNLKEKDLTVIGDGGTPLSEGQKARVSLARAVYQDADIYLLDDPLSAVDPRVSRHLFEQCIRQALKEKITILVTHQLQYLKDASQILILKDDKTVERGTYSEFLKSGVDIFSPFEKGNKQPASSPVLGTPTLMSESLVQSLPSPRPSLKDAAPEDQDIENIQVTLPLEDYLEGKVGFKTYKSYFTAGAGWPVITFLILVNIAAQVAYILQDWWLAFWANVQSDLYSGALIKEDVDTMIILNWCLRVYSGLTVSTIVFGITRSLLIIYILVNSSQTWHNKILESILRASVLFFNSNPIGRILNRFSKDIGHMDDLLPLIFLDFIQAFLLVIGVVGVMVAVIPWIAIPVIPLGIAFFFLQRYFSETSRDIKRLECATRSPVFSHLASSLRGLWTIRAYKAEQSFQELFDAHQDLHSEAWFLLLTTSRWLAVYLDVICAIFVTVVAFGALILAHALTPGQVGLVLSLALTLTGMFQWCIRQRTEVENLMISVERVMGYLDLEKEAPWEYKDHPPPPWSNEGRMHFYTVNFRHTSDGPLVLKNLSAVIESTKKVGIVGRTGAGKSSIFSAVFRLSEFEGLLSVDSCWIQATGLHNLRKKMSIILQEPVLFMETMRKNLDPFNEHTDKELWNALKEVQLKETIEGLPGKMDTALAETGANLSVGQRQLVCLARVILKKNQILIIDKATSNVDPRTDELIKKAIHEKFAQCTVITITHRLSTIIDSDMIMVLDSGTVKEYSPPHVLLQNSKSLFYKMVQQLGEAEATALTERAKQAHTKKK", "length": 1289, "header": "tr|A0A3Q1LXZ2-1|A0A3Q1LXZ2_BOVIN Isoform 1 of Multidrug resistance-associated protein 4 OS=Bos taurus OX=9913 GN=LOC521568 PE=3 SV=2 CANONICAL=A0A3Q1LXZ2-1" }, "locus": { "chromosome": "NKLS02000910.1", "start_pos": 1290803, "end_pos": 1101426, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066542.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066542.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062369.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062369.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:521568", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521568", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ], "pmid": "" }, { "name": "ABC-type xenobiotic transporter activity", "id": "GO:0008559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008559", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ], "pmid": "" }, { "name": "ABC-type glutathione S-conjugate transporter activity", "id": "GO:0015431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015431", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LXZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1053, "end_pos": 1055, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1169, "end_pos": 1171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 785, "end_pos": 787, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "66424", "name": "", "equation": "leukotriene B4(in) + ATP + H2O = leukotriene B4(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9RZT1-1", "A0AAA9T569-1", "A0AAA9SJG6-1", "A0AAA9TUR1-1", "A0AAA9S3M4-1", "G3MW08-1", "A0AAA9TZ11-1", "A0A3Q1LXZ2-1", "A0AAA9T4S3-1", "A0A3Q1LPI1-1", "A0AAA9TR50-1", "A0A3Q1ML89-1", "A0AAA9SMB4-1" ], "evidence": [ { "id": "66424", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/66424" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LPI1", "gene_name": "LOC107131247", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1LPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPI1" } ] } ] }, { "uniprot_ac": "A0A3Q1LXZ2", "gene_name": "LOC521568", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1LXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXZ2" } ] } ] }, { "uniprot_ac": "A0A3Q1ML89", "gene_name": "LOC100299180", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1ML89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML89" } ] } ] }, { "uniprot_ac": "A0AAA9RZT1", "gene_name": "LOC100337390", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9RZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZT1" } ] } ] }, { "uniprot_ac": "A0AAA9S3M4", "gene_name": "LOC100848700", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9S3M4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3M4" } ] } ] }, { "uniprot_ac": "A0AAA9SJG6", "gene_name": "LOC101906567", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9SJG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJG6" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0AAA9SJG6", "database": 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"ENSBTAG00000008467", "url": "https://www.ensembl.org/id/ENSBTAG00000008467" } ] } } ], "crossref": [ { "id": "A0A3Q1LY49", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LY49", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008467", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008467", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515853", "url": "https://www.ncbi.nlm.nih.gov/gene/515853", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MZT5", "url": "https://www.orthodb.org/?gene=F1MZT5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21404", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21404", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21404:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21404:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28339", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28339", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005204292", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204292", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "37887", "url": "https://www.rhea-db.org/rhea/37887", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LY49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LY49-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY49-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZT5", "url": "https://www.uniprot.org/uniprotkb/F1MZT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZT5-1", "url": "https://www.uniprot.org/uniprotkb/F1MZT5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALGNEPQTLLKDTNPMSWSQEPRGKELNPELGSGHLGRRSRESPGQCSRPKCGRSRCGGGRVKSRGETARAPVSRAGPGDKCGRRFEASALLRYVRWLAARGGASYRKGLKETAALLFQRNLKTVVEDNMECNSVVDGNVEEVPSKKVIKFNPPLYKQRYQFVKNLVEQHQPKKVADLGCGDVCLLAILKYQKCVEELVGVDINEGRLKWNGSRLSPCVGDHLDPRELDLAITLYHGSVLEKDCRLLGFDLAACIELIEHFDSEDLAKFPEVVFGYMCPAMIVISTPNSEFNSLFPCAVFRDSDHKFEWSRMQFQTWALDVASRYNYSVEFTGVGEPPTGAEDVGYCTQIGVFRRKAEAAELAVLEHHGEHVYEVVYTTSYPSLQQINYRRRVVIYLVYREVSRLKQKYQVSLRQHELEPEFIAPGNQTGKFTSDLPVPVLTEDDKAMEIAPQPFCIEDKFYVPLQRIIAYPRLGHLCGNVEKLREFLGDVIELNCDGSAVKVDLNDCSDF", "length": 512, "header": "tr|A0A3Q1LY49-1|A0A3Q1LY49_BOVIN Isoform 1 of Small RNA 2'-O-methyltransferase OS=Bos taurus OX=9913 GN=HENMT1 PE=3 SV=1 CANONICAL=A0A3Q1LY49-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LY49-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY49/entry", "sequence": { "sequence": "MALGNEPQTLLKDTNPMSWSQEPRGKELNPELGSGHLGRRSRESPGQCSRPKCGRSRCGGGRVKSRGETARAPVSRAGPGDKCGRRFEASALLRYVRWLAARGGASYRKGLKETAALLFQRNLKTVVEDNMECNSVVDGNVEEVPSKKVIKFNPPLYKQRYQFVKNLVEQHQPKKVADLGCGDVCLLAILKYQKCVEELVGVDINEGRLKWNGSRLSPCVGDHLDPRELDLAITLYHGSVLEKDCRLLGFDLAACIELIEHFDSEDLAKFPEVVFGYMCPAMIVISTPNSEFNSLFPCAVFRDSDHKFEWSRMQFQTWALDVASRYNYSVEFTGVGEPPTGAEDVGYCTQIGVFRRKAEAAELAVLEHHGEHVYEVVYTTSYPSLQQINYRRRVVIYLVYREVSRLKQKYQVSLRQHELEPEFIAPGNQTGKFTSDLPVPVLTEDDKAMEIAPQPFCIEDKFYVPLQRIIAYPRLGHLCGNVEKLREFLGDVIELNCDGSAVKVDLNDCSDF", "length": 512, "header": "tr|A0A3Q1LY49-1|A0A3Q1LY49_BOVIN Isoform 1 of Small RNA 2'-O-methyltransferase OS=Bos taurus OX=9913 GN=HENMT1 PE=3 SV=1 CANONICAL=A0A3Q1LY49-1" }, "locus": { "chromosome": "3", "start_pos": 34713452, "end_pos": 34701919, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086275.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086275.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062452.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062452.2" } ] } }, { "isoform_ac": "F1MZT5-1", "url": "https://www.uniprot.org/uniprotkb/F1MZT5/entry", "sequence": { "sequence": "MRETLVQSLGWEDPLEKRKATHSSILARRIPWTVVHRGLKETAALLFQRNLKTVVEDNMECNSVVDGNVEEVPSKKVIKFNPPLYKQRYQFVKNLVEQHQPKKVADLGCGDVCLLAILKYQKCVEELVGVDINEGRLKWNGSRLSPCVGDHLDPRELDLAITLYHGSVLEKDCRLLGFDLAACIELIEHFDSEDLAKFPEVVFGYMCPAMIVISTPNSEFNSLFPCAVFRDSDHKFEWSRMQFQTWALDVASRYNYSVEFTGVGEPPTGAEDVGYCTQIGVFRRKAEAAELAVLEHHGEHVYEVVYTTSYPSLQQINYRRRVVIYLVYREVSRLKQKYQVSLRQHELEPEFIAPGNQTGKFTSDLPVPVLTEDDKAMEIAPQPFCIEDKFYVPLQRIIAYPRLGHLCGNVEKLREFLGDVIELNCDGSAVKVDLNDCSDF", "length": 440, "header": "tr|F1MZT5-1|F1MZT5_BOVIN Computationally mapped isoform of Small RNA 2'-O-methyltransferase OS=Bos taurus OX=9913 GN=HENMT1 PE=3 SV=3 CANONICAL=A0A3Q1LY49-1" }, "locus": { "chromosome": "3", "start_pos": 34713452, "end_pos": 34702468, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011142.8", "url": "https://www.ensembl.org/id/ENSBTAT00000011142.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011142.7", "url": "https://www.ensembl.org/id/ENSBTAP00000011142.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 340, "start_aa": "Thr", "end_pos": 340, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr340", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "small RNA 2'-O-methyltransferase activity", "id": "GO:0090486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090486", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY49" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY49" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY49" } ], "pmid": "" }, { "name": "O-methyltransferase activity", "id": "GO:0008171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008171", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY49" } ], "pmid": "" }, { "name": "RNA methyltransferase activity", "id": "GO:0008173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008173", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY49" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulatory ncRNA-mediated gene silencing", "id": "GO:0031047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031047", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY49" } ], "pmid": "" }, { "name": "RNA methylation", "id": "GO:0001510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001510", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY49" } ], "pmid": "" }, { "name": "siRNA processing", "id": "GO:0030422", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030422", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY49" } ], "pmid": "" }, { "name": "piRNA processing", "id": "GO:0034587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034587", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY49" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY49" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY49", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" }, { "start_pos": 327, "end_pos": 329, "annotation": "n_glycosylation_sequon" }, { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "37887", "name": "", "equation": "small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LY49-1" ], "evidence": [ { "id": "37887", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/37887" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LY49", "gene_name": "HENMT1", "activity": [ { "ec_number": "2.1.1.386", 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"enzyme_annotation": [ { "ec_number": "2.1.1.386", "ec_name": "small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "2.1.1.386", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.386" }, { "id": "2.1.1.386", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.386" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 340 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 212, "end_pos": 214 }, { "start_pos": 327, "end_pos": 329 }, { "start_pos": 428, "end_pos": 430 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 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"sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": 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The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY65", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY65#function" }, { "database": "UniProtKB", "id": "ARBA00057180", "url": "https://www.uniprot.org/uniprotkb/ARBA00057180#function" }, { "database": "UniProtKB", "id": "A0A3Q1M2Y2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Y2#function" }, { "database": "UniProtKB", "id": "A0AAA9SVH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVH4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2D8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2D8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR59", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2D8", "locus": { "chromosome": "18", "start_pos": 2259188, "end_pos": 2339511, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016878", "url": "https://www.ensembl.org/id/ENSBTAG00000016878" } ] } } ], "crossref": [ { "id": "A0A3Q1M2D8", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M2D8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016878", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016878", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16692", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16692", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526642", "url": "https://www.ncbi.nlm.nih.gov/gene/526642", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039456", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039456", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049566", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049566", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049567", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049567", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HRRETCL", "url": "https://omabrowser.org/oma/group/HRRETCL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LY65", "url": "https://www.orthodb.org/?gene=A0A3Q1LY65", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2D8", "url": "https://www.orthodb.org/?gene=A0A3Q1M2D8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2Y2", "url": "https://www.orthodb.org/?gene=A0A3Q1M2Y2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46170", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46170", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46170:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46170:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17120", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17120", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LY65", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LY65-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2D8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2D8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2D8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2D8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2Y2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Y2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2Y2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Y2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVH4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RUB5", "url": "https://www.uniprot.org/uniprotkb/F6RUB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RUB5-1", "url": "https://www.uniprot.org/uniprotkb/F6RUB5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARWSSENVVVEFRDSQATAMSVDCVGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASLRFLLAHSPGVFLLNLKEVHVSRTLSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVDSQMQRLCANDILDGVDEFIESIALLPEPEKILHTQDTDHQHNSSHGEEEVLKEDPPSSLLEEKKSEQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSVHCSSHRVKMLVKFPAQYPNHAAPSFQFINPTTITSTMKAKLLKILKDTSLQKVKRNQSCLEPCLRQLVSCLESFVNQEDSASSNPFALPNSVTPPLPTFARVTTAYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERKSRRWKSKREGSDSGNRPIKAAGKVIIQDIACLLPVHKSLGELYILNVNDIQETCQKNAASALLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWARHPFGRQLLESLLAHYCRLRDVQTLAMLCSVFEAQSRPQGIPNPFGPFPSRSANLVVSHSRYPSFTSSGSCSSLSDPGFNTGGWNIVGRETEHISSPWGESSPEEIRFGSLTYSDPRERERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGVYCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLACGHGGHTSHMMEWFRTQEVCPTGCGCHCLLESTF", "length": 999, "header": "tr|A0A3Q1M2D8-1|A0A3Q1M2D8_BOVIN Isoform 1 of WD repeat domain 59 OS=Bos taurus OX=9913 GN=WDR59 PE=3 SV=2 CANONICAL=A0A3Q1M2D8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LY65-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY65/entry", "sequence": { "sequence": "MAARWSSENVVVEFRDSQATAMSVDCVGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVDSQMQRLCANDILDGVDEFIESIALLPEPEKILHTQDTDHQHNSSHGEEEVLKEDPPSSLLEEKKSEQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSVHCSSHRVKMLVKFPAQYPNHAAPSFQFINPTTITSTMKAKLLKILKDTSLQKVKRNQSCLEPCLRQLVSCLESFVNQEDSASSNPFALPNSVTPPLPTFARVTTAYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERMSPRSARRRWSIQAINDFPKSRRWKSKREGSDSGNRPIKAAGKVIIQDIACLLPVHKSLGELYILNVNDIQETCQKNAASALLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWARHPFGRQLLESLLAHYCRLRDVQTLAMLCSVFEAQSRPQGIPNPFGPFPSRSANLVVSHSRYPSFTSSGSCSSLSDPGFNTGGWNIVGRETEHISSPWGESSPEEIRFGSLTYSDPRERERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGVYCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLACGHGGHTSHMMEWFRTQEVCPTGCGCHCLLESTF", "length": 993, "header": "tr|A0A3Q1LY65-1|A0A3Q1M2D8_BOVIN Computationally mapped isoform of WD repeat domain 59 OS=Bos taurus OX=9913 GN=WDR59 PE=3 SV=1 CANONICAL=A0A3Q1M2D8-1" }, "locus": { "chromosome": "18", "start_pos": 2339464, "end_pos": 2259740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074610.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074610.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060566.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060566.1" } ] } }, { "isoform_ac": "A0A3Q1M2D8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2D8/entry", "sequence": { "sequence": "MAARWSSENVVVEFRDSQATAMSVDCVGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASLRFLLAHSPGVFLLNLKEVHVSRTLSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVDSQMQRLCANDILDGVDEFIESIALLPEPEKILHTQDTDHQHNSSHGEEEVLKEDPPSSLLEEKKSEQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSVHCSSHRVKMLVKFPAQYPNHAAPSFQFINPTTITSTMKAKLLKILKDTSLQKVKRNQSCLEPCLRQLVSCLESFVNQEDSASSNPFALPNSVTPPLPTFARVTTAYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERKSRRWKSKREGSDSGNRPIKAAGKVIIQDIACLLPVHKSLGELYILNVNDIQETCQKNAASALLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWARHPFGRQLLESLLAHYCRLRDVQTLAMLCSVFEAQSRPQGIPNPFGPFPSRSANLVVSHSRYPSFTSSGSCSSLSDPGFNTGGWNIVGRETEHISSPWGESSPEEIRFGSLTYSDPRERERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGVYCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLACGHGGHTSHMMEWFRTQEVCPTGCGCHCLLESTF", "length": 999, "header": "tr|A0A3Q1M2D8-1|A0A3Q1M2D8_BOVIN Isoform 1 of WD repeat domain 59 OS=Bos taurus OX=9913 GN=WDR59 PE=3 SV=2 CANONICAL=A0A3Q1M2D8-1" }, "locus": { "chromosome": "18", "start_pos": 2339464, "end_pos": 2259740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071782.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071782.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067577.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067577.2" } ] } }, { "isoform_ac": "A0A3Q1M2Y2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2Y2/entry", "sequence": { "sequence": "MAARWSSENVVVEFRDSQATAMSVDCVGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVDSQMQRLCANDILDGVDEFIESIALLPEPEKILHTQDTDHQHNSSHGEEEVLKEDPPSSLLEEKKSEQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSVHCSSHRVKMLVKFPAQYPNHAAPSFQFINPTTITSTMKAKLLKILKDTSLQKVKRNQSCLEPCLRQLVSCLESFVNQEDSASSNPFALPNSVTPPLPTFARVTTAYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERKSRRWKSKREGSDSGNRPIKAAGKVIIQDIACLLPVHKSLGELYILNVNDIQETCQKNAASALLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWARHPFGRQLLESLLAHYCRLRDVQTLAMLCSVFEAQSRPQGIPNPFGPFPSRSANLVVSHSRYPSFTSSGSCSSLSDPGFNTGGWNIVGRETEHISSPWGESSPEEIRFGSLTYSDPRERERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGVYCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLACGHGGHTSHMMEWFRTQEMLTSNHRQHPF", "length": 969, "header": "tr|A0A3Q1M2Y2-1|A0A3Q1M2D8_BOVIN Computationally mapped isoform of WD repeat domain 59 OS=Bos taurus OX=9913 GN=WDR59 PE=3 SV=2 CANONICAL=A0A3Q1M2D8-1" }, "locus": { "chromosome": "18", "start_pos": 2339464, "end_pos": 2259447, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082953.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082953.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064401.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064401.2" } ] } }, { "isoform_ac": "A0AAA9SVH4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVH4/entry", "sequence": { "sequence": "MAARWSSENVVVEFRDSQATAMSVDCVGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVDSQMQRLCANDILDGVDEFIESIALLPEPEKILHTQDTDHQHNSSHGEEEVLKEDPPSSLLEEKKSEQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSVHCSSHRVKMLVKFPAQYPNHAAPSFQFINPTTITSTMKAKLLKILKDTSLQKVKRNQSCLEPCLRQLVSCLESFVNQEDSASSNPFALPNSVTPPLPTFARVTTAYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERVWSLATVATDLCLGPKSDPDLETPWARHPFGRQLLESLLAHYCRLRDVQTLAMLCSVFEAQSRPQGIPNPFGPFPSRSANLVVSHSRYPSFTSSGSCSSLSDPGFNTGGWNIVGRETEHISSPWGESSPEEIRFGSLTYSDPRERERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGVYCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLACGHGGHTSHMMEWFRTQEVCPTGCGCHCLLESTF", "length": 902, "header": "tr|A0AAA9SVH4-1|A0A3Q1M2D8_BOVIN Computationally mapped isoform of WD repeat domain 59 OS=Bos taurus OX=9913 GN=WDR59 PE=3 SV=1 CANONICAL=A0A3Q1M2D8-1" }, "locus": { "chromosome": "18", "start_pos": 2339464, "end_pos": 2259740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106649.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106649.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087190.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087190.1" } ] } }, { "isoform_ac": "F6RUB5-1", "url": "https://www.uniprot.org/uniprotkb/F6RUB5/entry", "sequence": { "sequence": "MPPSKVTGRSHARASGTLALCSGILMTASRTILQPRATKGSTFISGKMAVGRLARPYKATHASSVTWTGQCLSLISWSPALWTPTSTFGISTGASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVDSQMQRLCANDILDGVDEFIESIALLPEPEKILHTQDTDHQHNSSHGEEEVLKEDPPSSLLEEKKSEQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSVHCSSHRVKMLVKFPAQYPNHAAPSFQFINPTTITSTMKAKLLKILKDTSLQKVKRNQSCLEPCLRQLVSCLESFVNQEDSASSNPFALPNSVTPPLPTFARVTTAYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERKSRRWKSKREGSDSGNRPIKAAGKVIIQDIACLLPVHKSLGELYILNVNDIQETCQKNAASALLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWARHPFGRQLLESLLAHYCRLRDVQTLAMLCSVFEAQSRPQGIPNPFGPFPSRSANLVVSHSRYPSFTSSGSCSSLSDPGFNTGGWNIVGRETEHISSPWGESSPEEIRFGSLTYSDPRERERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGVYCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLACGHGGHTSHMMEWFRTQEVCPTGCGCHCLLESTF", "length": 917, "header": "tr|F6RUB5-1|A0A3Q1M2D8_BOVIN Computationally mapped isoform of WD repeat domain 59 OS=Bos taurus OX=9913 GN=WDR59 PE=3 SV=1 CANONICAL=A0A3Q1M2D8-1" }, "locus": { "chromosome": "18", "start_pos": 2321645, "end_pos": 2259740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022452.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022452.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022452.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022452.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 591, "start_aa": "Thr", "end_pos": 591, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr591", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 594, "start_aa": "Thr", "end_pos": 594, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr594", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A286YB35-1", "protein_name": "GATOR2 complex protein WDR59 isoform X1", "gene_name": "wdr59", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAARWSSENVVVEFRDAQANAMSVDCLGQHAVLSGRRFLYVVNLETPSEAPRKISRQSKWDVGTVQWNPHKSDAHIFAASSNQRVDLYTWRDGSGKSHTSLQGHTRVISDLDWSWFEPEFLVTSSVDTYIYIWDTSDTRRPTVTLSAVAGASQVKWNRRNHYCLASSHDGDVRIWDKRKSNTAVEYVAAHLSKINGLDWHPDNEYILATSSQDNSVRFWDYRQPRKYLDILSCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWSTLELNSPVHAFVGHDDVVYEFQWRPQKEGSKDCQLVTLSRDQTLRIWRVDPQLQKLCCANEIVDELTTETEKTLRSQDSEPPLSPGFTADNSLDQFDGPQSGLSSSAKNDIPQTLQQEFSLVNLQIRNVNVEMDAVNRSCFVSADCGANRVRLVVKFPAQYPNNAAPSFQFVPPTNISSSMKIKIQKILTDTSLQKVKRNQNCLEPCVRQLVSCLESDGVMEDGSNPYVLTNPVTPALPAFPRVTNTYGSYQDANIPFPRTSGARFCGTGSLVYFTRPMTMHRATPPTEPTPRSLSALSAYHSGVMTPMKMRTESQTTLRLYSGSPTRTDKDQVSISSFYYKERKPLSAARRWSVQTIHECPKSRRWKGKREGGDYSNRPIKLAGKVIIQEISCLLSVHKALGETYVLNVNDIQDTCQKNGAAALAVARRDLAKVWALASASTNLNLSPDPDPDAGTPWAKHPFGRHLLETLLEHYSQLSDVQSLAMLCSVFRGHGSPQEYFTLYGHQQPRPAVFTPHHSRYPSFTSSSVTSGSCSSTSDSANTPWNTGGRESEHPPSWGESTPDDYRYANQTYTDPREREKEQHDMNKRLLDPSNSWQFDDFKKCYGEILHRWGMKDKRAEVLKFVSCPPEPHKGIEFGVYCCHCRSQARGTQCAVCKRFTFQCSICHVAVRGSSNFCLSCGHGGHTSHMMDWFRSQDVCPTGCGCHCLQQSTF", "length": 982 }, "evidence": [ { "id": "A0A3Q1M2D8", "url": "https://omabrowser.org/oma/group/A0A3Q1M2D8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8I6G9F8-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "Wdr59", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAARWSSENVVVEFRDSQATAMSVDCVGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPAVALSAVAGASQVKWNKKNANYLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHIFATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRRQKEGSKDYQLVTWSRDQTLRMWRVDYQMQRLCANDILDGVDEFIESISLLPEPEKTLHPQDTDHQPSLSHGEEDGNVTDVLAIKEDPPSSLLEERRSDQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSVHCSNHRVKMLVTFPAQYPNNAAPSFQFINPTTITSAVKAKLLKILKDTSLQKVKRNQSCLEPCLRQLVSCLESFVNQEDSASSNPFALPNSVTPPLPTFARVTTAYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERMSPRSARRRWSIQAINDFPKSRRWKSKREGSDSGNRPIKAAGKVIIQDVSCLLPVHKSLGELYILNVNDTQETCQKNATSAMLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWARHPFGRQLLESLLAHYCRLRDVQTLAMLCSVFEAQSRPQGLPNPFGPFPNRSSNFVVSHSRYPSFTSSGSCSSMSDPGFNTGGWSIVSLAGRETEHISSPWGESSPEELRFGSLTYSDPRERERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGVYCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVCPTGCGCHCLLESTF", "length": 1003 }, "evidence": [ { "id": "A0A3Q1M2D8", "url": "https://omabrowser.org/oma/group/A0A3Q1M2D8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q03897-1", "protein_name": "Maintenance of telomere capping protein 5", "gene_name": "MTC5", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MCSSINEGPYNSPTFGKSLSLKVDGGFNAVSINPSGRDIVLASRQGLYIIDLDDPFTPPRWLHHITPWQVADVQWSPHPAKPYWIVSTSNQKAIIWNLAKSSSNAIEFVLHGHSRAITDINFNPQHPDVLATCSVDTYVHAWDMRSPHRPFYSTSSWRSAASQVKWNYKDPNVLASSHGNDIFVWDLRKGSTPLCSLKGHVSSVNSIDFNRFKYSEIMSSSNDGTVKFWDYSKSTTESKRTVTTNFPIWRGRYLPFGEGYCIMPMVGGNNAVYLINLCDDDDSEQNKKTKLQPIYAFKGHSDRVIDFLWRSRHTCDGDYDDREFQLVTWSKDCDLKLWPISDSIYGKVNFDRGKRLEEKLPDYDYCSYNKEPENRENVQKNEFRRLRENFVTTSGLKKNKTNHITWLSGIRMNSATSQEDLFNETKIQNLGEEVSAIGHKFPKVVFEKISVSTRELCLTLNGPWSEENPDDYIFLRISINFPLNYPNKGDPPKFTIEENSNLTMSKRQEILSNLATIGQKYTDSNLYCLEPCIRFVLGEKVSLEDIEEGQEPLLNFDIADHIDFEELSSLDSSYSDSQNPENLSSQSDIESYKEALVFPDTSNQGLDFGRNLALDTTPVPNGCGSCWTATGELFCFFANEKKPEKKQNAIIKLSQKEAGVEKHPFKIEPQVLYDKEVDSSVITAADELKARPKRYVDTLGLGGGTNGDSRTYFDDETSSDDSFDSVADDWDDILRNDIIVRTKIPILRGNFKAFSSVHSESGKTVESTKKNKNLVISKNFSSLLSDRKELALEYLFMDATPEGFARNNALVAEKFDLDEISHCWQILSDMLIDQSDYDPYTTIWNNHPMGIKWFIKEAIVYFERQQNLQMLAMLCCVILSARRKKIPARYYGQELENMEGTIVFNDNESQNTSFWKGSDAFSTRSRSSTVTPNFYGNHLRGKNIHGGDNSSIRSDDHHARLRTHNTLNGSSKFTEPAQKQGSRAISSSPFHSRMPDIKVELLHDDIIEAYEQEDLLHLEVSDIPKFQTYIYQYSKLLFRWGLPLERVKILKVSTDFRSSYSSQGIPPNNNKKSPYNGVLTHWIENNEFGEEKFLARNCNYCDLRVTRSSFICGNCQHVLHSSCARIWWEIGDECPSGCGCNCPEMFDA", "length": 1148 }, "evidence": [ { "id": "A0A3Q1M2D8", "url": "https://omabrowser.org/oma/group/A0A3Q1M2D8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q6PJI9-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "WDR59", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAARWSSENVVVEFRDSQATAMSVDCLGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVDSQMQRLCANDILDGVDEFIESISLLPEPEKTLHTEDTDHQHTASHGEEEALKEDPPRNLLEERKSDQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSVHCSNHRVKMLVKFPAQYPNNAAPSFQFINPTTITSTMKAKLLKILKDTALQKVKRGQSCLEPCLRQLVSCLESFVNQEDSASSNPFALPNSVTPPLPTFARVTTAYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERKSRRWKSKREGSDSGNRQIKAAGKVIIQDIACLLPVHKSLGELYILNVNDIQETCQKNAASALLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWARHPFGRQLLESLLAHYCRLRDVQTLAMLCSVFEAQSRPQGLPNPFGPFPNRSSNLVVSHSRYPSFTSSGSCSSMSDPGLNTGGWNIAGREAEHLSSPWGESSPEELRFGSLTYSDPRERERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGVYCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVCPTGCGCHCLLESTF", "length": 974 }, "evidence": [ { "id": "A0A3Q1M2D8", "url": "https://omabrowser.org/oma/group/A0A3Q1M2D8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C0M0-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "Wdr59", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAARWSSENVVVEFRDSQATAMSVDCLGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANYLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHIFATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNASDLNAPVHTFVGHDDVVLEFQWRRQKEGSKDYQLVTWSRDQTLRMWRVDYQMQRLCANDILDGVDEFIESISLLPEPEKTPHPQDIDHQPSLSHGEEDAIKEDPPSSLLEEKRSDQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSVHCSNHRVKMLVTFPAQYPNNAAPSFQFINPTTITSAVKAKLLKILKDTSLQKVKRNQSCLEPCLRQLVSCLESFVNQEDSASSNPFALQNSVTPPLPTFARVTTAYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPTEPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERKSRRWKSKREGSDSGNRPIKAAGKVIIQDVSCLLPVHKSLGELYILNVNDTQETCQKNATSAMLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWARHPFGRQLLESLWGDRESTRVCGPPLSGARLAHYCQLRDVQTLAMLCSVFEAQSRPQGLPNPFGPFPNRSSNLVVSHSRYPSFTSSGSCSSMSDPGFNTGGWNIAGRETEHISSPWGESSPEELRFGSLTYSDPRERERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKGIEFGVYCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVCPTGCGCHCLLESTF", "length": 992 }, "evidence": [ { "id": "A0A3Q1M2D8", "url": "https://omabrowser.org/oma/group/A0A3Q1M2D8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VKK2-1", "protein_name": "GATOR2 complex protein Wdr59", "gene_name": "Wdr59", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPPTETLRPGERGTAGGPGAGAPEQTYIVRQSNKYYEHRDSQATAMSVDYSGQWVLLAGRGHLALQRLGQDDGSLRRHERQSKYEVSVAEFAICPSRKEYCAIATSQHIDIVRWGTAEPHYEMSLRGHTRTVTDIDWHGKDPNLLVSCSIDTFSHIWDLREPRKPALSLNAVCMSGATQVGFNRVSGNLLAAAHDGDLRIWDIRKGSCPTHYITAHLNRVHGINWSHKRETCLATASQDGTVKYFDVCNPRRAEKIITTMSPVWRARYTPIGNGLVSIVVPHLGRGENSLLLWSNSKQTDPICSFVGHTDVILDFAWRPNRESSNEIELVTWSRDRTLRVWKIDDNMLKLCEPSAEEIESRFEPDLSELRVPTPPEFLHPRSILVAASLPISTGDGACNTLPMARSPSFGGGYYRREEPHIARSLTDQPTCSLHHEFSLLNTNMPHVEVDTLDAIKRYACFKICAGGHTVILQVTFTTSYPSPSAPPDFQLCQGTTLSSEVSGVLLKVLRCNALQRVKKSRTCLEQCLRALVAAMKKKVAAVGGADRSQLLLQSPRLEGALSSTLHDACIPYPRTSGVHFNAIGMLTTFAQPVNNKRLTLRQHTALTPRTFSSINGSGLLGNVMATAQREANASFYLQERMISGKPGKQRAIRQMNGSPVVHVYDTSSLLHISRRMAREFSLDKCNIAETCRKNGEICRQHGRLDLVPVWLLAELIATPQIPHETLNDLLFYKDPFKKSLLESLIMHYAISGDIQTAVLLACLFDKCPTGGGAIMEKTVRLPPQLNSQISPYHTVLPLDVKSSSSSNTWQQLKQLRSNSWSDSLDLEIKQIQSDAYACSLIRRTKMPLFDQFKRAYAEILFGWQLLSKRALILKHTQNTPPPVQGVEFVTECRKCAKPKRTPKCEPCKRPVLFCVLCRLPVKGAANACLACGHGGHIDHMMQWFEKHNVCATCGCKCLERTSELLALLS", "length": 969 }, "evidence": [ { "id": "A0A3Q1M2D8", "url": "https://omabrowser.org/oma/group/A0A3Q1M2D8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2D8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2D8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2D8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2D8" } ], "pmid": "" }, { "name": "Seh1-associated complex", "id": "GO:0035859", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035859", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2D8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2D8" } ], "pmid": "" }, { "name": "GATOR2 complex", "id": "GO:0061700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061700", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2D8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2D8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of TORC1 signaling", "id": "GO:1904263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904263", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2D8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2D8" } ], "pmid": "" }, { "name": "cellular response to amino acid starvation", "id": "GO:0034198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2D8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2D8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 501, "end_pos": 503, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M2D8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 999, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M2D8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M2D8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M2D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2D8" }, { "id": "PS50908", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50908" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RWD", "eco_id": "ECO_0000259", "start_pos": 418, "end_pos": 519, "start_aa": "Gln", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 591, 594 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 384, "end_pos": 386 }, { "start_pos": 501, "end_pos": 503 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LY70-1", "uniprot_ac": "A0A3Q1LY70", "uniprot_id": "A0A3Q1LY70_BOVIN", "mass": { "chemical_mass": 140729.0, "monoisotopic_mass": 140729.0 }, "refseq": { "ac": "NP_001193920", "name": "nardilysin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193920" }, "gene_names": [ { "name": "NRDC", "type": "recommended", "evidence": [ { "id": "A0A3Q1LY70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70" } ] }, { "name": "NRD1", "type": "synonym", "evidence": [ { "id": "NP_001193920", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193920" } ] }, { "name": "NRDC", "type": "synonym", "evidence": [ { "id": "NP_001193920", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193920" } ] } ], "protein_names": [ { "name": "Nardilysin", "type": "recommended", "evidence": [ { "id": "A0A3Q1LY70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70/entry#names_and_taxonomy" } ] }, { "name": "3.4.24.61", "type": "synonym", "evidence": [ { "id": "A0A3Q1LY70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70/entry#names_and_taxonomy" } ] }, { "name": "N-arginine dibasic convertase", "type": "synonym", "evidence": [ { "id": "A0A3Q1LY70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70/entry#names_and_taxonomy" } ] }, { "name": "Nardilysin convertase", "type": "synonym", "evidence": [ { "id": "A0A3Q1LY70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70/entry#names_and_taxonomy" } ] }, { "name": "nardilysin (N-arginine dibasic convertase)", "type": "synonym", "evidence": [ { "id": "NP_001193920", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193920" } ] }, { "name": "nardilysin", "type": "synonym", "evidence": [ { "id": "NP_001193920", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193920" } ] } ], "function": [ { "annotation": "Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH).", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70#function" }, { "database": "UniProtKB", "id": "ARBA00055893", "url": "https://www.uniprot.org/uniprotkb/ARBA00055893#function" }, { "database": "UniProtKB", "id": "A0A3Q1ME26", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME26#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NRDC", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70", "locus": { "chromosome": "3", "start_pos": 94540296, "end_pos": 94437449, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021174", "url": "https://www.ensembl.org/id/ENSBTAG00000021174" } ] } } ], "crossref": [ { "id": "A0A3Q1LY70", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LY70", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021174", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021174", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511254", "url": "https://www.ncbi.nlm.nih.gov/gene/511254", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001431", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001431", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032632", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032632", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511254", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511254", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "INQVMEH", "url": "https://omabrowser.org/oma/group/INQVMEH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LY70", "url": "https://www.orthodb.org/?gene=A0A3Q1LY70", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1ME26", "url": "https://www.orthodb.org/?gene=A0A3Q1ME26", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43690", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43690", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43690:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43690:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00675", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00675", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16187", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16187", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193920", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LY70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LY70-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ME26", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ME26-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME26-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NP78", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NP78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NP78-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NP78-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRRVAVAAVCATGRKLCEAGRELAALSRIEARGRCEDSAAARHFPTLTMPGRNKAKSTCSCPDLQPNGQDLGESGRVARLGADESEEEGRRGPVNNAGDPEIIKSPSDPKQYRYIKLRNGLQALLISDLSNMEGKMGDATDDEEEEEEEEEDDDDDDDDDDDDDDEDSGAEIEDDDEEGFDDEDEFEDDDDEHDDDLDAEDNELEELEERAEARKKTTEKQQLQSLFLLWSKLTDKLWFKSTYTKMSSTQLFKTRNLNGVVGAESRSAPVQHFAGWQEEEQQGETDTVLSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPKRNNTDTHARLREFWLRYYSAHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPKPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSYLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAHTVFQYLKMLQKLGPEKRIFEEIQKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYSMEDIENSWAELWKSDFELNPDLHLPAENKYIATDFMLKAFDCPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFSSTPAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYSRWSMIDKYRALMDGLSLESLLSFVREFKAQLFVEGLVQGNVTSTESTDFLKYVVDKLNFMPLEQEMPVQFQVVELPSGHHLCKVRALNRGDANSEVTVYYQSGARSLKEYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEDAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTRQYLFDRLAHEIEALKSFSKSDLVNWFKAHRGPGSKMLSVHVVGFGKYELEEDGTPSGEDSNSSCDVMQLTYLPASPLLVDCTVPIVDIRGFTSRLNLLPYHKIVK", "length": 1231, "header": "tr|A0A3Q1LY70-1|A0A3Q1LY70_BOVIN Isoform 1 of Nardilysin OS=Bos taurus OX=9913 GN=NRDC PE=3 SV=1 CANONICAL=A0A3Q1LY70-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LY70-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70/entry", "sequence": { "sequence": "MLRRVAVAAVCATGRKLCEAGRELAALSRIEARGRCEDSAAARHFPTLTMPGRNKAKSTCSCPDLQPNGQDLGESGRVARLGADESEEEGRRGPVNNAGDPEIIKSPSDPKQYRYIKLRNGLQALLISDLSNMEGKMGDATDDEEEEEEEEEDDDDDDDDDDDDDDEDSGAEIEDDDEEGFDDEDEFEDDDDEHDDDLDAEDNELEELEERAEARKKTTEKQQLQSLFLLWSKLTDKLWFKSTYTKMSSTQLFKTRNLNGVVGAESRSAPVQHFAGWQEEEQQGETDTVLSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPKRNNTDTHARLREFWLRYYSAHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPKPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSYLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAHTVFQYLKMLQKLGPEKRIFEEIQKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYSMEDIENSWAELWKSDFELNPDLHLPAENKYIATDFMLKAFDCPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFSSTPAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYSRWSMIDKYRALMDGLSLESLLSFVREFKAQLFVEGLVQGNVTSTESTDFLKYVVDKLNFMPLEQEMPVQFQVVELPSGHHLCKVRALNRGDANSEVTVYYQSGARSLKEYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEDAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTRQYLFDRLAHEIEALKSFSKSDLVNWFKAHRGPGSKMLSVHVVGFGKYELEEDGTPSGEDSNSSCDVMQLTYLPASPLLVDCTVPIVDIRGFTSRLNLLPYHKIVK", "length": 1231, "header": "tr|A0A3Q1LY70-1|A0A3Q1LY70_BOVIN Isoform 1 of Nardilysin OS=Bos taurus OX=9913 GN=NRDC PE=3 SV=1 CANONICAL=A0A3Q1LY70-1" }, "locus": { "chromosome": "3", "start_pos": 94539775, "end_pos": 94437614, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075740.1", "url": "https://www.ensembl.org/id/ENSBTAT00000075740.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060576.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060576.1" } ] } }, { "isoform_ac": "A0A3Q1ME26-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME26/entry", "sequence": { "sequence": "MLRRVAVAAVCATGRKLCEAGRELAALSRIEARGRCEDSAAARHFPTLTMPGRNKAKSTCSCPDLQPNGQDLGESGRVARLGADESEEEGRRGPVNNAGDPEIIKSPSDPKQYRYIKLRNGLQALLISDLSNMEGKMGDATDDEEEEEEEEEDDDDDDDDDDDDDDEDSGAEIEDDDEEGFDDEDEFEDDDDEHDDDLDAEDNELEELEERAEARKKTTEKQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPKRNNTDTHARLREFWLRYYSAHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPKPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSYLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAHTVFQYLKMLQKLGPEKRIFEEIQKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYSMEDIENSWAELWKSDFELNPDLHLPAENKYIATDFMLKAFDCPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFSSTPAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYSRWSMIDKYRALMDGLSLESLLSFVREFKAQLFVEGLVQGNVTSTESTDFLKYVVDKLNFMPLEQEMPVQFQVVELPSGHHLCKVRALNRGDANSEVTVYYQSGARSLKEYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEDAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTRQYLFDRLAHEIEALKSFSKSDLVNWFKAHRGPGSKMLSVHVVGFGKYELEEDGTPSGEDSNSSCDVMQLTYLPASPLLVDCTVPIVDIRGFTSRLNLLPYHKIVK", "length": 1163, "header": "tr|A0A3Q1ME26-1|A0A3Q1LY70_BOVIN Computationally mapped isoform of Nardilysin OS=Bos taurus OX=9913 GN=NRDC PE=3 SV=1 CANONICAL=A0A3Q1LY70-1" }, "locus": { "chromosome": "3", "start_pos": 94539775, "end_pos": 94437614, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076084.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076084.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072406.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072406.1" } ] } }, { "isoform_ac": "A0ABI0NP78-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NP78/entry", "sequence": { "sequence": "MLRRVAVAAVCATGRKLCEAGRELAALSRIEARGRCEDSAAARHFPTLTMPGRNKAKSTCSCPDLQPNGQDLGESGRVARLGADESEEEGRRGPVNNAGDPEIIKSPSDPKQYRYIKLRNGLQALLISDLSNMEGKMGDATDDEEEEEEEEEDDDDDDDDDDDDDDEDSGAEIEDDDEEGFDDEDEFEDDDDEHDDDLDAEDNELEELEERAEARKKTTEKQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPKRNNTDTHARLREFWLRYYSAHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPKPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSYLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAHTVFQYLKMLQKLGPEKRIFEEIQKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYSMEDIENSWAELWKSDFELNPDLHLPAENKYIATDFMLKAFDCPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFSSTPAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYSRWSMIDKYRALMDGLSLESLLSFVREFKAQLFVEGLVQGNVTSTESTDFLKYVVDKLNFMPLEQEMPVQFQVVELPSGHHLCKVRALNRGDANSEVTVYYQSGARSLKEYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEDAFNTQIEALKSFSKSDLVNWFKAHRGPGSKMLSVHVVGFGKYELEEDGTPSGEDSNSSCDVMQLTYLPASPLLVDCTVPIVDIRGFTSRLNLLPYHKIVK", "length": 1124, "header": "tr|A0ABI0NP78-1|A0ABI0NP78_BOVIN Computationally mapped isoform of Nardilysin convertase OS=Bos taurus OX=9913 GN=NRDC PE=3 SV=1 CANONICAL=A0A3Q1LY70-1" }, "locus": { "chromosome": "3", "start_pos": 94539775, "end_pos": 94437614, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154748.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154748.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107659.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107659.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:511254", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511254", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B0S6B9-1", "protein_name": "Nardilysin", "gene_name": "nrd1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPQTNKFKCAAASSPAQSAGPDRGEPVRDPNAPPGDSGGDENQGDPQIIKSPSDPKQYRYIELSNGLRALLISDLSGLDGKAEDEDDEDSEEEEAEEEAEGEEEEGDSGEGTDEESEEEGDSQDSDFEELDEESDQKKKKGSEKQSAAALCIGVGSFSDPNDLPGLAHFLEHMVFMGSEKYPSENGFDAFLKKHGGSDNASTDCERTIFQFDVQRKRFKEALDRWAQFFICPLMIEDAIDREVEAVDSEYQLAKPSDSHRKEMLFGSLAKPDHPMSKFCWGNAQTLKTEPKEKNINVYKRLREFWKRHYSAHYMTLAVQSKESLDTLEEWVREIFSQVPNNGQLKPDFSDKLNPFETPAFNKLYRVVPVRKVHALTITWALPPQEKHYRVKPLHYIAWLIGHEGTGSILSMLRRKCWALALFGGNSETGFDQNTTYSIFSISITLTDEGFQNFYEVAHLVFQYLKMLQTLGPQQRIYEEIQKIEANEFHYQEQTDPIEYVEDICENMQLFPKEDFLTGDQLMFEFKPEVISAALNLLTPEKANLLLLSPEHEGQCPLREKWFGTQYSTEDIEQHWREIWAKDFDLNPSLHLPAENKFIATDFALKTSDCPDTEYPVRIMNNDRGCLWYKKDNKFKIPKAYVRFHLISPVVQKSPKNLVLFDLFVNILVHNLAEPAYEADVAQLEYKLVAGEHGLVIKVKGFNHKLPLLFNLIVDYLADFSAAPDVFSMFAEQLKKTYFNILIKPEKLGKDVRLLILEHSRWSTIQKYQAVLDGLSVDELMEFVSGFKSELYAEGLLQGNVTSTESMGFLQYVTEKLQFKKLSVEVPVLFRVVELPQKHHLCKVKSLNKGDANSEVTVYYQSGPKNLREHTLMELLVMHMEEPCFDFLRTKETLGYHVYPTCRNTSGVLGFSVTVETQATKFNTELVETKIEEFLVSFGEKMNSLSDDAFRTQVTALVKLKGCEDTHLGEEVDRNWTEVVTQQYVFDRLSREIDALKLMTKAELVNWFMEHRGEGNRKLSVHVVGYGVEENDPPNDPHPGEEEEASKMSLYGEVSKLTFLQASNLLASVSTITDIRAFTQTLNLFPYHKILK", "length": 1091 }, "evidence": [ { "id": "A0A3Q1LY70", "url": "https://omabrowser.org/oma/group/A0A3Q1LY70/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F4HNU6-1", "protein_name": "Nardilysin-like", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSSMKSVSALDNVVVKSPNDRRLYRVIELENGLCALLIHDPDIYPEGSVPDQIDEDDEDGEEEDSDGSSEDDDDDEDDEEDGEGDEEDEDEDEDEVKGKGDHQTKKAAAAMCVSMGSFLDPPEAQGLAHFLEHMLFMGSTEFPDENEYDSYLSKHGGSSNAYTEMEHTCYHFEVKREFLQGALKRFSQFFVAPLMKTEAMEREVLAVDSEFNQALQNDACRLQQLQCYTSAKGHPFNRFAWGNKKSLSGAMENGVDLRECIVKLYKEYYHGGLMKLVVIGGESLDMLESWVVELFGDVKNGSKIRPTLEAEGPIWKGGKLYRLEAVKDVHILDLTWTLPPLRSAYVKKPEDYLAHLLGHEGRGSLHSFLKAKGWATSLSAGVGDDGINRSSLAYVFGMSIHLTDSGLEKIYDIIGYIYQYLKLLRDVSPQEWIFKELQDIGNMDFRFAEEQPADDYAAELSENMLAYPVEHVIYGDYVYQTWDPKLIEDLMGFFTPQNMRIDVVSKSIKSEEFQQEPWFGSSYIEEDVPLSLMESWSNPSEVDNSLHLPSKNQFIPCDFSIRAINSDVDPKSQSPPRCIIDEPFMKFWYKLDETFKVPRANTYFRINLKGAYASVKNCLLTELYINLLKDELNEIIYQASIAKLETSLSMYGDKLELKVYGFNEKIPALLSKILAIAKSFMPNLERFKVIKENMERGFRNTNMKPLNHSTYLRLQLLCKRIYDSDEKLSVLNDLSLDDLNSFIPELRSQIFIEALCHGNLSEDEAVNISNIFKDSLTVEPLPSKCRHGEQITCFPMGAKLVRDVNVKNKSETNSVVELYYQIEPEEAQSTRTKAVLDLFHEIIEEPLFNQLRTKEQLGYVVECGPRLTYRVHGFCFCVQSSKYGPVHLLGRVDNFIKDIEGLLEQLDDESYEDYRSGMIARLLEKDPSLLSETNDLWSQIVDKRYMFDFSHKEAEELRSIQKKDVISWYKTYFRESSPKCRRLAVRVWGCDTNMKETQTDQKAVQVIADAVAFKSTSKFYPSLC", "length": 1024 }, "evidence": [ { "id": "A0A3Q1LY70", "url": "https://omabrowser.org/oma/group/A0A3Q1LY70/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O43847-1", "protein_name": "Nardilysin", "gene_name": "NRDC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRRVTVAAVCATRRKLCEAGRELAALWGIETRGRCEDSAAARPFPILAMPGRNKAKSTCSCPDLQPNGQDLGENSRVARLGADESEEEGRRGSLSNAGDPEIVKSPSDPKQYRYIKLQNGLQALLISDLSNMEGKTGNTTDDEEEEEVEEEEEDDDEDSGAEIEDDDEEGFDDEDEFDDEHDDDLDTEDNELEELEERAEARKKTTEKQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPRKNNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYSIEDIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFDCPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYARWSMIDKYQALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFKPLEQEMPVQFQVVELPSGHHLCKVKALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEEAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVNWFKAHRGPGSKMLSVHVVGYGKYELEEDGTPSSEDSNSSCEVMQLTYLPTSPLLADCIIPITDIRAFTTTLNLLPYHKIVK", "length": 1151 }, "evidence": [ { "id": "A0A3Q1LY70", "url": "https://omabrowser.org/oma/group/A0A3Q1LY70/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P47245-1", "protein_name": "Nardilysin", "gene_name": "Nrdc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRRVAVAAVFATGRKLRCEAGRDVTAVGRIEARGLCEESAKPFPTLTMPGRNKAKSTCSCPDLQPNGQDLGESGRVARLGADESEEEGRSLSNVGDPEIIKSPSDPKQYRYIKLQNGLQALLISDLSNVEGKTGNATDEEEEEEEEEEEGEEEEEEEEDDDDDDDEDSGAEIQDDDEEGFDDEEEFDDDEHDDDDLDNEENELEELEERVEARKKTTEKQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPKKNNIDTHARLREFWMRYYSAHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPKPNFSHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSYLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAHTVFQYLKMLQKLGPEKRVFEEIQKIEDNEFHYQEQTDPVEYVENMCENMQLYPRQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGRCDLKEKWFGTQYSIEDIENSWTELWKSNFDLNSDLHLPAENKYIATDFTLKAFDCPETEYPAKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLTEFSSTPAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYSRWSMIDKYRALMDGLSLESLLNFVKDFKSQLFVEGLVQGNVTSTESMDFLRYVVDKLNFVPLEREMPVQFQVVELPSGHHLCKVRALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSETVDKKIEEFLSSFEEKIENLTEDAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVSWFKAHRGPGSKMLSVHVVGYGKYELEEDGAPVCEDPNSREGMQLIYLPPSPLLAESTTPITDIRAFTATLSLFPYHKIVK", "length": 1161 }, "evidence": [ { "id": "A0A3Q1LY70", "url": "https://omabrowser.org/oma/group/A0A3Q1LY70/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BHG1-1", "protein_name": "Nardilysin", "gene_name": "Nrdc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRRVAVAAVCVTGRKLRCEAGRELTALGRIEARGLCEESSKPFPTLTMPGRNKAKSTCSCPDLQPNGQDLGESGRLARLGADESEEEGRSFSNVGDPEIIKSPSDPKQYRYIKLQNGLQALLISDLSNVEGKTGNATDEEEEEEEEEEEEDDDDDDDDDDDDEDSGAEIQDDDEEGFDDEEEFDDDDDDEHDDDDLENEENELEELEERVEARKKTTEKQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPKKNNIDTHARLREFWMRYYSAHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPKPNFSHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSYLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAHTVFQYLKMLQKLGPEKRVFEEIQKIEDNEFHYQEQTDPVEYVENMCENMQLYPRQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGRCDLKEKWFGTQYSIEDIENSWTELWKSNFDLNPDLHLPAENKYIATDFTLKAFDCPETEYPAKIVNTAQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLTEFSSTPAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYSRWSMIDKYQALMDGLSLDSLLNFVKDFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFAPLEREMPVQFQVVELPSGHHLCKVRALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSETVDKKIEEFLSSFEEKIENLTEDAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVSWFKAHRGPGSKMLSVHVVGYGKYELEEDGAPFGEDSNSREGMQLTYLPPSPVLAESTTPITDIRAFTATLSLFPYHKIVK", "length": 1161 }, "evidence": [ { "id": "A0A3Q1LY70", "url": "https://omabrowser.org/oma/group/A0A3Q1LY70/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VYT3-1", "protein_name": "3.4.24.-", "gene_name": "Nrd1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLWQRYSAHLFRRFEFHVRTKRRSPITQLAGVRAITYSSLCKMTDQVKYLDIPDKSETDKKLYKTLLLGNGLHALIVSDPSPMPHDGFTTSESSSSKSTVSTSSSIISRSESTSSTSTDSESSEESSSEEGDEKLAACALLIDYGSFAEPTKYQGLAHFLEHMIFMGSEKYPKENIFDAHIKKCGGFANANTDCEDTLFYFEVAEKHLDSSLDYFTALMKAPLMKQEAMQRERSAVDSEFQQILQDDETRRDQLLASLATKGFPHGTFAWGNMKSLKENVDDAELHKILHEIRKEHYGANRMYVCLQARLPIDELESLVVRHFSGIPHNEVKAPDLSSFNYKDAFKAEFHEQVFFVKPVENETKLELTWVLPNVRQYYRSKPDQFLSYLLGYEGRGSLCAYLRRRLWALQLIAGIDENGFDMNSMYSLFNICIYLTDEGFKNLDEVLAATFAYVKLFANCGSMKDVYEEQQRNEETGFRFHAQRPAFDNVQELVLNLKYFPPKDILTGKELYYEYNEEHLKELISHLNEMKFNLMVTSRRKYDDISAYDKTEEWFGTEYATIPMPEKWRKLWEDSVPLPELFLPESNKYVTDDFTLHWHSMGRPEVPDSPKLLIKTDTCELWFRQDDKFDLPEAHMAFYFISPMQRQNAKNDAMCSLYEEMVRFHVCEELYPAISAGLSYSLSTIEKGLLLKVCGYNEKLHLIVEAIAEGMLNVAETLDENMLSAFVKNQRKAFFNALIKPKALNRDIRLCVLERIRWLMINKYKCLSSVILEDMREFAHQFPKELYIQSLIQGNYTEESAHNVMNSLLSRLNCKQIRERGRFLEDITVKLPVGTSIIRCHALNVQDTNTVITNFYQIGPNTVRVESILDLLMMFVDEPLFDQLRTKEQLGYHVGATVRLNYGIAGYSIMVNSQETKTTADYVEGRIEVFRAKMLQILRHLPQDEYEHTRDSLIKLKLVADLALSTEMSRNWDEIINESYLFDRRRRQIEVLRTLQKDEIINFVISIDGDNMRKLSVQVIGHRPAGMPEPLCGEDTAKCASKSDDESESENDDDDDEDEEEEESSEEEEEEEKEKEGLKGEDEDDLFYSLENKLNIVFLPAKFNNAFIITDIEKFKDDQYVYPQQKTQPKEEDELISAHIADAIRQV", "length": 1147 }, "evidence": [ { "id": "A0A3Q1LY70", "url": "https://omabrowser.org/oma/group/A0A3Q1LY70/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70" } ], "pmid": "" }, { "name": "endopeptidase activator activity", "id": "GO:0061133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061133", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70" } ], "pmid": "" }, { "name": "positive regulation of membrane protein ectodomain proteolysis", "id": "GO:0051044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051044", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LY70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1048, "end_pos": 1050, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1088, "end_pos": 1090, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1187, "end_pos": 1189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 344, "end_pos": 346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 438, "end_pos": 440, "annotation": "n_glycosylation_sequon" }, { "start_pos": 578, "end_pos": 580, "annotation": "n_glycosylation_sequon" }, { "start_pos": 944, "end_pos": 946, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LY70-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1231, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LY70-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LY70" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LY70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70" }, { "id": "PF05193", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05193" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M16 C-terminal", "eco_id": "ECO_0000259", "start_pos": 442, "end_pos": 627, "start_aa": "Thr", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LY70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70" }, { "id": "PF00675", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00675" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M16 N-terminal", "eco_id": "ECO_0000259", "start_pos": 288, "end_pos": 416, "start_aa": "Thr", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LY70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LY70" }, { "id": "PF16187", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16187" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M16 middle/third", "eco_id": "ECO_0000259", "start_pos": 633, "end_pos": 914, "start_aa": "Phe", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.24.61", "ec_name": "Hydrolysis of polypeptides, preferably at -Xaa-|-Arg-Lys-, and less commonly at -Arg-|-Arg-Xaa-, in which Xaa is not Arg or Lys.", "evidence": [ { "id": "3.4.24.61", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.24.61" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1048, "end_pos": 1050 }, { "start_pos": 1088, "end_pos": 1090 }, { "start_pos": 1187, "end_pos": 1189 }, { "start_pos": 344, "end_pos": 346 }, { "start_pos": 438, "end_pos": 440 }, { "start_pos": 578, "end_pos": 580 }, { "start_pos": 944, "end_pos": 946 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", 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Isoform 1 of Urotensin-2 OS=Bos taurus OX=9913 GN=UTS2 PE=3 SV=1 CANONICAL=A0A3Q1LYG0-1" }, "locus": { "chromosome": "16", "start_pos": 45530356, "end_pos": 45524414, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077845.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077845.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062617.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062617.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100295833", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100295833", "resource": "KEGG Pathway" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B834-1", "protein_name": "Urotensin-2", "gene_name": "UTS2", "tax_id": 9823, 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"MDRVPFCCLLFIGLLNPLLSLPVTDTGERTLQLPVLEEDALRALEELERMALLQTLRQTMGTEAGESPGEAGPSTETPTPRGSMRKAFAGQNSNTVLSRLLARTRKQHKQHGAAPECFWKYCI", "length": 123 }, "evidence": [ { "id": "A0A3Q1LYG0", "url": "https://omabrowser.org/oma/group/A0A3Q1LYG0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9QZQ4-1", "protein_name": "Urotensin-2", "gene_name": "Uts2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDRVPFCCLLFVGLLNPLLSFPVTDTGEMSLQLPVLEENALRALEELERTALLQTLRQTVGTEAEGSLGQADPSAETPTPRGSLRKALTGQDSNTVLSRLLARTRKQRKQHGTAPECFWKYCI", "length": 123 }, "evidence": [ { "id": "A0A3Q1LYG0", "url": "https://omabrowser.org/oma/group/A0A3Q1LYG0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYG0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of blood pressure", "id": "GO:0008217", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008217", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYG0" } ], "pmid": "" }, { "name": "blood vessel diameter maintenance", "id": "GO:0097746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097746", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYG0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYG0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYG0" } ], "pmid": "" } ] } ] }, 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"length": 1119, "header": "tr|E1BAU4-1|E1BAU4_BOVIN Computationally mapped isoform of Protocadherin 17 OS=Bos taurus OX=9913 GN=PCDH17 PE=4 SV=3 CANONICAL=A0A3Q1LYJ3-1" }, "locus": { "chromosome": "12", "start_pos": 5221533, "end_pos": 5107210, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013751.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013751.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013751.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013751.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510554", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510554", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": 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"id": "A0A3Q1LYJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYJ3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYJ3" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYJ3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYJ3" } ], "pmid": "" }, { "name": "synaptic membrane adhesion", "id": "GO:0099560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099560", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYJ3" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYJ3" } ], "pmid": "" }, { "name": "presynaptic active zone assembly", "id": "GO:1904071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904071", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYJ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 268, "end_pos": 270, "annotation": "n_glycosylation_sequon" }, { "start_pos": 441, "end_pos": 443, "annotation": 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}, { "start_pos": 568, "end_pos": 570 }, { "start_pos": 592, "end_pos": 594 }, { "start_pos": 824, "end_pos": 826 }, { "start_pos": 844, "end_pos": 846 }, { "start_pos": 941, "end_pos": 943 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 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sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYS1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LYS1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 281, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LYS1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LYS1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LYS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS1" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } 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"categories": [] }, { "id": "ENSBTAG00000016836", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016836", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16929", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16929", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "528655", "url": "https://www.ncbi.nlm.nih.gov/gene/528655", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018955", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018955", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036784", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036784", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528655", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528655", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NEMPSIC", "url": "https://omabrowser.org/oma/group/NEMPSIC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LYU1", "url": "https://www.orthodb.org/?gene=A0A3Q1LYU1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11947", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11947", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11947:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11947:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02518", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02518", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10436", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10436", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-204174", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-204174", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5362517", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5362517", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9837999", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9837999", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192886", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYU1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SE41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE41-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLARLLRVATSAGPGPELRAAGPSVSRSLTSDSGSGPAPERGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLEFKDKSAEDAKTIYDFTDTVIRIRNRHNDVIPTMAEGVVEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSLSHRKHVGSINPNCSVVEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHADKGVYPPIQVHVTLGKEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA", "length": 438, "header": "tr|A0A3Q1LYU1-1|A0A3Q1LYU1_BOVIN Isoform 1 of Protein-serine/threonine kinase OS=Bos taurus OX=9913 GN=PDK1 PE=3 SV=1 CANONICAL=A0A3Q1LYU1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LYU1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1/entry", "sequence": { "sequence": 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"https://www.ensembl.org/id/ENSBTAP00000078177.1" } ] } }, { "isoform_ac": "A0AAA9SE41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SE41/entry", "sequence": { "sequence": "MRLARLLRVATSAGPGPELRAAGPSVSRSLTSDSGSGPAPERGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLEFKDKSAEDAKTIYDFTDTVIRIRNRHNDVIPTMAEGVVEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSLSHRKHVGSINPNCSVVEVIKAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHADKGVYPPIQVHVTLGKEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA", "length": 412, "header": "tr|A0AAA9SE41-1|A0A3Q1LYU1_BOVIN Computationally mapped isoform of Protein-serine/threonine kinase OS=Bos taurus OX=9913 GN=PDK1 PE=3 SV=1 CANONICAL=A0A3Q1LYU1-1" }, "locus": { "chromosome": "2", "start_pos": 24068840, "end_pos": 24029195, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087935.1", "url": 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"uniprot_canonical_ac": "E7F3U3-1", "protein_name": "Protein-serine/threonine kinase", "gene_name": "pdk1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRIFRTLLNAASKQIDFYSRFSPSPLSMKQFIDFGSENACEKTSFTFLRQELPVRLANIMKEIDLLPDNLLRTPSVRLVQSWYMQSFQDILEFKDKDADDETVNHDFTDAVIKIRNRHNDVVPTMAQGVVEYKETYGTDPITSQNMQYFLDRFYMSRISIRMLLNQHTLLFGGKVRDNPAHPKQIGSIDPSCRVTDVVKDAYENARNLCDRYYMNSPELVLEEFNVKGPDKPVTVVYVPSHLYHMVFELFKNAMRATMELYEDAMEYPPVHVQIVLGHEDLTVKVSDRGGGVPLRKIDRLFTYTYSTAPRPQMDTSRATPLAGYGYGLPISRLYARYFQGDLKLYSMEGFGTDAVIYIRALSTDSIERLPVYNKSAWKHYKTIHEADDWCVPSKEPKDMTTFRSF", "length": 405 }, "evidence": [ { "id": "A0A3Q1LYU1", "url": "https://omabrowser.org/oma/group/A0A3Q1LYU1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1NLP2-1", "protein_name": "Protein-serine/threonine kinase", "gene_name": "PDK1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRLLRALLRCASPGSIPQQVDFYSRFSPSPLSMKQFLDFGSENACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYVQSLQEILDFKDKSSEDSGAIHSFTDTVIKIRNRHNDVIPTMAQGVIEYKESFGIDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKINPAHPKHIGSIDPSCNVVGVIRDGYESAKSLCDLYYMSSPELVLEELNIKSPGQPMQVVYVPSHLYHMVFELFKNAMRATMEHNADRCIYPPIHVHVTLGNEDLTVKMSDRGGGVPMRKIDRLFNYMYSTAPRPRVETSRATPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESIERLPVYNKAAWKHYKANHEADDWCVPSSEPKDMTTFRST", "length": 408 }, "evidence": [ { "id": "A0A3Q1LYU1", "url": "https://omabrowser.org/oma/group/A0A3Q1LYU1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S069-1", "protein_name": "Protein-serine/threonine kinase", "gene_name": "PDK1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRLARLLRGAASAGPGPGLRAACPSASRSLTSDSGSGPAPELGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKTIYDFTDTVIRIRNRHNDVIPTMAQGVVEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSLSHQKHIGSINPNCNVVEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHADKGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA", "length": 438 }, "evidence": [ { "id": "A0A3Q1LYU1", "url": "https://omabrowser.org/oma/group/A0A3Q1LYU1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8BFP9-1", "protein_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial", "gene_name": "Pdk1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLARLLRGGTSVRPLCAVPCASRSLASASASGSGPASELGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKTIYEFTDTVIRIRNRHNDVIPTMAQGVTEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGSPSHRKHIGSINPNCDVVEVIKDGYENARRLCDLYYVNSPELELEELNAKSPGQTIQVVYVPSHLYHMVFELFKNAMRATMEHHADKGVYPPIQVHVTLGEEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESVERLPVYNKAAWKHYKANHEADDWCVPSREPKDMTTFRSS", "length": 434 }, "evidence": [ { "id": "A0A3Q1LYU1", "url": "https://omabrowser.org/oma/group/A0A3Q1LYU1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9SBJ1-1", "protein_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial", "gene_name": "PDK", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAVKKACEMFPKSLIEDVHKWGCMKQTGVSLRYMMEFGSKPTERNLLISAQFLHKELPIRVARRAIELQTLPYGLSDKPAVLKVRDWYLESFRDMRAFPEIKDSGDEKDFTQMIKAVKVRHNNVVPMMALGVNQLKKGMNSGNLDEIHQFLDRFYLSRIGIRMLIGQHVELHNPNPPLHTVGYIHTKMSPMEVARNASEDARSICFREYGSAPEINIYGDPSFTFPYVPTHLHLMMYELVKNSLRAVQERFVDSDRVAPPIRIIVADGIEDVTIKVSDEGGGIARSGLPRIFTYLYSTARNPLEEDVDLGIADVPVTMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLGDSQEPLP", "length": 366 }, "evidence": [ { "id": "A0A3Q1LYU1", "url": "https://omabrowser.org/oma/group/A0A3Q1LYU1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "pyruvate dehydrogenase (acetyl-transferring) kinase activity", "id": "GO:0004740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004740", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ], "pmid": "" }, { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ], "pmid": "" }, { "name": "pyruvate dehydrogenase complex", "id": "GO:0045254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045254", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "cell population proliferation", "id": "GO:0008283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ], "pmid": "" }, { "name": "regulation of glucose metabolic process", "id": "GO:0010906", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010906", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ], "pmid": "" }, { "name": "phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0043491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043491", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ], "pmid": "" }, { "name": "regulation of pyruvate decarboxylation to acetyl-CoA", "id": "GO:0010510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010510", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway in response to oxidative stress", "id": "GO:0008631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008631", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ], "pmid": "" }, { "name": "hypoxia-inducible factor-1alpha signaling pathway", "id": "GO:0097411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097411", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-203946", "name": "PDK isozymes phosphorylate PDHC subunit E1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A7MB35-1", "P11966-1", "A0A3Q1MR85-1", "A0A3Q1LYU1-1", "F1N206-1" ], "evidence": [ { "id": "R-BTA-203946", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-203946" } ] }, { "id": "R-BTA-9838035", "name": "CLPXP binds mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "P15690-1", "P20000-1", "Q02337-1", "Q32LG3-1", "P20004-1", "A6QLI6-1", "P00829-1", "A7MB35-1", "F1MTT7-1", "Q148N0-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q04467-1", "Q0NXR6-1", "Q29RZ0-1", "Q3MHX5-1", "F1MXW5-1", "F1N155-1", "F1N338-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "F1N206-1", "Q3ZCH0-1", "Q2KHU4-1" ], "evidence": [ { "id": "R-BTA-9838035", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838035" } ] }, { "id": "R-BTA-9838081", "name": "LONP1 degrades mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "Q2KIE6-1", "P15690-1", "P20000-1", "Q32LG3-1", "P20004-1", "A0AAA9S896-1", "P00829-1", "Q5EAD4-1", "Q2TBR0-1", "F1MTT7-1", "Q148N0-1", "P11181-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q0NXR6-1", "Q29RZ0-1", "F1MXW5-1", "F1N338-1", "G3MWG4-1", "A0A140T871-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "O02691-1", "A0A3Q1LR42-1", "Q3ZCH0-1" ], "evidence": [ { "id": "R-BTA-9838081", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838081" } ] }, { "id": "R-BTA-9838093", "name": "LONP1 binds mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "Q2KIE6-1", "P15690-1", "P20000-1", "Q32LG3-1", "P20004-1", "A0AAA9S896-1", "P00829-1", "Q5EAD4-1", "Q2TBR0-1", "F1MTT7-1", "Q148N0-1", "P11181-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q0NXR6-1", "Q29RZ0-1", "F1MXW5-1", "F1N338-1", "G3MWG4-1", "A0A140T871-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "O02691-1", "A0A3Q1LR42-1", "Q3ZCH0-1" ], "evidence": [ { "id": "R-BTA-9838093", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838093" } ] }, { "id": "R-BTA-9838289", "name": "CLPXP degrades mitochondrial matrix proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29RK1-1", "P15690-1", "P20000-1", "Q02337-1", "Q32LG3-1", "P20004-1", "A6QLI6-1", "P00829-1", "A7MB35-1", "F1MTT7-1", "Q148N0-1", "A0A3Q1LS67-1", "G3N0R5-1", "G3MWN1-1", "P11966-1", "P22600-1", "Q04467-1", "Q0NXR6-1", "Q29RZ0-1", "Q3MHX5-1", "F1MXW5-1", "F1N155-1", "F1N338-1", "A0A3Q1LS03-1", "A0A3Q1LYU1-1", "F1N206-1", "Q3ZCH0-1", "Q2KHU4-1" ], "evidence": [ { "id": "R-BTA-9838289", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9838289" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T871", "gene_name": "GLUD1", "activity": [ { "ec_number": "1.4.1.3", "activity": "L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+).", "evidence": [ { "id": "A0A140T871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T871" } ] }, { "ec_number": "1.4.1.3", "activity": "", "evidence": [ { "id": "A0A140T871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T871" } ] } ] }, { "uniprot_ac": "A0A3Q1LR42", "gene_name": "NADK2", "activity": [ { "ec_number": "2.7.1.23", "activity": "NAD(+) + ATP = ADP + NADP(+) + H(+).", "evidence": [ { "id": "A0A3Q1LR42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR42" } ] }, { "ec_number": "2.7.1.23", "activity": "", "evidence": [ { "id": "A0A3Q1LR42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR42" } ] } ] }, { "uniprot_ac": "A0A3Q1LS03", "gene_name": "", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0A3Q1LS03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "A0A3Q1LS03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS03" } ] } ] }, { "uniprot_ac": "A0A3Q1LS67", "gene_name": "ECH1", "activity": [ { "ec_number": "5.3.3.21", "activity": "a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA.", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] }, { "ec_number": "5.3.3.21", "activity": "", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] } ] }, { "uniprot_ac": "A0A3Q1LYU1", "gene_name": "PDK1", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "A0A3Q1LYU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU1" } ] } ] }, { "uniprot_ac": "A0A3Q1MR85", "gene_name": "PDK2", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "A0A3Q1MR85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR85" } ] } ] }, { "uniprot_ac": "A0AAA9S896", "gene_name": "LONP1", "activity": [ { "ec_number": "3.4.21.53", "activity": "Hydrolysis of proteins in presence of ATP.", "evidence": [ { "id": "A0AAA9S896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S896" } ] }, { "ec_number": "3.4.21.53", "activity": "", "evidence": [ { "id": "A0AAA9S896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S896" } ] } ] }, { "uniprot_ac": "A6QLI6", "gene_name": "ALAS1", "activity": [ { "ec_number": "2.3.1.37", "activity": "succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA.", "evidence": [ { "id": "A6QLI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLI6" } ] }, { "ec_number": "2.3.1.37", "activity": "", "evidence": [ { "id": "A6QLI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLI6" } ] } ] }, { "uniprot_ac": "A7MB35", "gene_name": "PDHA1", "activity": [ { "ec_number": "1.2.4.1", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "A7MB35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB35" } ] }, { "ec_number": "1.2.4.1", "activity": "", "evidence": [ { "id": "A7MB35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB35" } ] } ] }, { "uniprot_ac": "F1MTT7", "gene_name": "ECI1", "activity": [ { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "F1MTT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTT7" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "F1MTT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTT7" } ] } ] }, { "uniprot_ac": "F1MXW5", "gene_name": "OXSM", "activity": [ { "ec_number": "2.3.1.41", "activity": "a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2.", "evidence": [ { "id": "F1MXW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXW5" } ] }, { "ec_number": "2.3.1.41", "activity": "", "evidence": [ { "id": "F1MXW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXW5" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N206", "gene_name": "DLD", "activity": [ { "ec_number": "1.8.1.4", "activity": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+).", "evidence": [ { "id": "F1N206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N206" } ] }, { "ec_number": "1.8.1.4", "activity": "", "evidence": [ { "id": "F1N206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N206" } ] } ] }, { "uniprot_ac": "F1N338", "gene_name": "HADH", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "F1N338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N338" } ] } ] }, { "uniprot_ac": "G3MWG4", "gene_name": "IARS2", "activity": [ { "ec_number": "6.1.1.5", "activity": "tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate.", "evidence": [ { "id": "G3MWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWG4" } ] }, { "ec_number": "6.1.1.5", "activity": "", "evidence": [ { "id": "G3MWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWG4" } ] } ] }, { "uniprot_ac": "G3MWN1", "gene_name": "ARG2", "activity": [ { "ec_number": "3.5.3.1", "activity": "L-arginine + H2O = urea + L-ornithine.", "evidence": [ { "id": "G3MWN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWN1" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "G3MWN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MWN1" } ] } ] }, { "uniprot_ac": "G3N0R5", "gene_name": "HSPD1", "activity": [ { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "G3N0R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0R5" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "G3N0R5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N0R5" } ] } ] }, { "uniprot_ac": "O02691", "gene_name": "HSD17B10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.239", "activity": "testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.53", "activity": "androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H(+).", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "O02691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O02691" } ] } ] }, { "uniprot_ac": "P00829", "gene_name": "ATP5F1B", "activity": [ { "ec_number": "7.1.2.2", "activity": "ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out).", "evidence": [ { "id": "P00829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00829" } ] }, { "ec_number": "7.1.2.2", "activity": 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"ec_number": "1.3.8.5", "activity": "2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "Q0NXR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0NXR6" } ] }, { "ec_number": "1.3.8.5", "activity": "", "evidence": [ { "id": "Q0NXR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0NXR6" } ] } ] }, { "uniprot_ac": "Q148N0", "gene_name": "OGDH", "activity": [ { "ec_number": "1.2.4.2", "activity": "N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2.", "evidence": [ { "id": "Q148N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148N0" } ] }, { "ec_number": "1.2.4.2", "activity": "", "evidence": [ { "id": "Q148N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q148N0" } ] } ] }, { "uniprot_ac": "Q29RK1", "gene_name": "CS", "activity": [ { "ec_number": "2.3.3.1", "activity": "oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+).", "evidence": [ { "id": "Q29RK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RK1" } ] }, { "ec_number": "2.3.3.1", "activity": "", "evidence": [ { "id": "Q29RK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RK1" } ] } ] }, { "uniprot_ac": "Q29RZ0", "gene_name": "ACAT1", "activity": [ { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "Q29RZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ0" } ] }, { "ec_number": "2.3.1.9", "activity": "", "evidence": [ { "id": "Q29RZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RZ0" } ] } ] }, { "uniprot_ac": "Q2KHU4", "gene_name": "CLPP", "activity": [ { "ec_number": "3.4.21.92", "activity": "Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).", "evidence": [ { "id": "Q2KHU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU4" } ] }, { "ec_number": "3.4.21.92", "activity": "", "evidence": [ { "id": "Q2KHU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHU4" } ] } ] }, { "uniprot_ac": "Q2KIE6", "gene_name": "HMGCS2", "activity": [ { "ec_number": "2.3.3.10", "activity": "acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).", "evidence": [ { "id": "Q2KIE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIE6" } ] }, { "ec_number": "2.3.3.10", "activity": "", "evidence": [ { "id": "Q2KIE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIE6" } ] } ] }, { "uniprot_ac": "Q2TBR0", "gene_name": "PCCB", "activity": [ { "ec_number": "6.4.1.3", "activity": "propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBR0" } ] }, { "ec_number": "6.4.1.3", "activity": "", "evidence": [ { "id": "Q2TBR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBR0" } ] } ] }, { "uniprot_ac": "Q32LG3", "gene_name": "MDH2", "activity": [ { "ec_number": "1.1.1.37", "activity": "(S)-malate + NAD(+) = oxaloacetate + NADH + H(+).", "evidence": [ { "id": "Q32LG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LG3" } ] }, { "ec_number": "1.1.1.37", "activity": "", "evidence": [ { "id": "Q32LG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LG3" } ] } ] }, { "uniprot_ac": "Q3MHX5", "gene_name": "SUCLG2", "activity": [ { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q3MHX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHX5" } ] }, { "ec_number": "6.2.1.4", "activity": "itaconate + GTP + CoA = itaconyl-CoA + GDP + phosphate.", "evidence": [ { "id": "Q3MHX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHX5" } ] }, { "ec_number": "6.2.1.4", "activity": "", "evidence": [ { "id": "Q3MHX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHX5" } ] } ] }, { "uniprot_ac": "Q3ZCH0", "gene_name": "HSPA9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q3ZCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZCH0" } ] } ] }, { "uniprot_ac": "Q5EAD4", "gene_name": "ACADSB", "activity": [ { "ec_number": "1.3.8.1", "activity": "a short-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "Q5EAD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD4" } ] }, { "ec_number": "1.3.8.5", "activity": "2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "Q5EAD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD4" } ] }, { "ec_number": "1.3.8.1", "activity": "", "evidence": [ { "id": "Q5EAD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD4" } ] }, { "ec_number": "1.3.8.5", "activity": "", "evidence": [ { "id": "Q5EAD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAD4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LYU1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 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[], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 224, "end_pos": 226 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 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{ "database": "Ensembl Transcript", "id": "ENSBTAT00000106501.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106501.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096448.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096448.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:100138908", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138908", "resource": "KEGG Pathway" }, { "id": "R-BTA-9753281", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9753281", "resource": "Reactome", "description": "Paracetamol ADME" }, { "id": "R-BTA-9757110", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9757110", "resource": "Reactome", "description": "Prednisone ADME" } ], "orthologs": [ { "uniprot_canonical_ac": "O75310-1", "protein_name": "UDP-glucuronosyltransferase 2B11", "gene_name": "UGT2B11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTLKWTSVLLLIHLSCYFSSGSCGKVLVWAAEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWSDIRKDSFWLYFSQEQEILWELYDIFRNFCKDVVSNKKVMKKLQESRFDIVFADAVFPCGELLAALLNIRFVYSLRFTPGYTIERHSGGLIFPPSYIPIVMSKLSDQMTFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNVDFVGGFHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTMSSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAAHDLTWFQYHSLDVIGFLLACVATVIFIITKFCLFCFWKFARKGKKGKRD", "length": 529 }, "evidence": [ { "id": "A0A3Q1LYU5", "url": "https://omabrowser.org/oma/group/A0A3Q1LYU5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q62789-1", "protein_name": "UDP-glucuronosyltransferase 2B7", "gene_name": "Ugt2b7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPQKWISALLLLQISFCFRSGNCGKVLVWPLEYSHWMNLKIILDELVQRGHEVTVLRPSSSVSLDPKKASGLVYETSPTTSNNDEVEKSFYPVGDMWTYDVPKYTCLRYYPSLNKMFGQFSDLWLQLCREVVSNKELIAKLKESQFDVVLSDAVGPCGELIAEILQLPFVYSLRFATAPGIEKYSAGQPFPPSYVPIILSGFSGQMTFMERVENMLCLLYFDSWFESFPAKDWDPFFSEILGRPTTMVDTMKKAEIWLIRSYWDLEFPRPSLPNIEFVGGLHCQPAKPLPKEMEDFAQSSGEHGVWVFSLGSMIRNITQERANTIASALAQIPQKVFWRFEGKKPDTLGPNTRVFKWIPQNDLLGHPKTKAFVTHGGANGIYESIHYGIPPMVGIPLFAEQRDNVAHMVAKGAAVSIDFHTMSSSDLLNALKAVINNPSYKKKVMWLSAIHHDQPLKPLDRAVFWIEFVMRHKGAKHLRPLAHNLALVSVHSLDVIGFLLACVLAIVLLAVKCCLFLYRFFVKVAKNKRD", "length": 530 }, "evidence": [ { "id": "A0A3Q1LYU5", "url": "https://omabrowser.org/oma/group/A0A3Q1LYU5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glucuronosyltransferase activity", "id": "GO:0015020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYU5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYU5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21032", "name": "", "equation": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T3U6-1", "G3N150-1", "F1MFF6-1", "F1MRL5-1", "E1BBB3-1", "E1BJU8-1", "A0AAA9S6P8-1", "A0A3Q1M7T0-1", "A0A3Q1MKS1-1", "A0A3Q1LYU5-1", "A0AAA9TS57-1" ], "evidence": [ { "id": "21032", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21032" } ] }, { "id": "R-BTA-158546", "name": "UGTs glucuronate APAP to APAP-GlcA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-158601" ], "output_participant_list": [ "R-ALL-158604" ], "enzyme_list": [ "E1BJU8-1", "A0A3Q1LYU5-1", "F1MFF6-1", "E1BBB3-1" ], "evidence": [ { "id": "R-BTA-158546", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-158546" } ] }, { "id": "R-BTA-9758661", "name": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. 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"n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LYY4-1", "uniprot_ac": "A0A3Q1LYY4", "uniprot_id": "A0A3Q1LYY4_BOVIN", "mass": { "chemical_mass": 71129.0, "monoisotopic_mass": 71129.0 }, "refseq": { "ac": "XP_024854292", "name": "carnitine O-acetyltransferase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854292" }, "gene_names": [ { "name": "CRAT", "type": "recommended", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] }, { "name": "CRAT", "type": "synonym", "evidence": [ { "id": "XP_024854292", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854292" } ] } ], "protein_names": [ { "name": "Carnitine O-acetyltransferase", "type": "recommended", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4/entry#names_and_taxonomy" } ] }, { "name": "2.3.1.137", "type": "synonym", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4/entry#names_and_taxonomy" } ] }, { "name": "2.3.1.7", "type": "synonym", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4/entry#names_and_taxonomy" } ] }, { "name": "Carnitine acetyltransferase", "type": "synonym", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4/entry#names_and_taxonomy" } ] }, { "name": "carnitine O-acetyltransferase isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024854292", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854292" } ] } ], "function": [ { "annotation": "Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M201", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M201#function" }, { "database": "UniProtKB", "id": "ARBA00058613", "url": "https://www.uniprot.org/uniprotkb/ARBA00058613#function" }, { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4#function" }, { "database": "UniProtKB", "id": "F6QH77", "url": "https://www.uniprot.org/uniprotkb/F6QH77#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRAT", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4", "locus": { "chromosome": "11", "start_pos": 99559600, "end_pos": 99572595, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001932", "url": "https://www.ensembl.org/id/ENSBTAG00000001932" } ] } } ], "crossref": [ { "id": "A0A3Q1LYY4", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LYY4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001932", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001932", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512902", "url": "https://www.ncbi.nlm.nih.gov/gene/512902", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000542", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000542", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039551", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039551", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042572", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042572", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LYY4", "url": "https://www.orthodb.org/?gene=A0A3Q1LYY4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M201", "url": "https://www.orthodb.org/?gene=A0A3Q1M201", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22589", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22589", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22589:SF50", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22589:SF50", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00755", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00755", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-389887", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389887", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-70895", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70895", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024854292", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854292", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17177", "url": "https://www.rhea-db.org/rhea/17177", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "21136", "url": "https://www.rhea-db.org/rhea/21136", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "44828", "url": "https://www.rhea-db.org/rhea/44828", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "44860", "url": "https://www.rhea-db.org/rhea/44860", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "44972", "url": "https://www.rhea-db.org/rhea/44972", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "44976", "url": "https://www.rhea-db.org/rhea/44976", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "44980", "url": "https://www.rhea-db.org/rhea/44980", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "44984", "url": "https://www.rhea-db.org/rhea/44984", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "44988", "url": "https://www.rhea-db.org/rhea/44988", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "44992", "url": "https://www.rhea-db.org/rhea/44992", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "44996", "url": "https://www.rhea-db.org/rhea/44996", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45000", "url": "https://www.rhea-db.org/rhea/45000", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "45004", "url": "https://www.rhea-db.org/rhea/45004", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYY4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M201", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M201", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M201-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M201-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S709", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S709", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S709-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S709-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QH77", "url": "https://www.uniprot.org/uniprotkb/F6QH77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QH77-1", "url": "https://www.uniprot.org/uniprotkb/F6QH77-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENGQQKEKVKPLGLLKPSSLMKVSSRFKAHQDSLPRLPVPPLQQTLDHYLKALQPIVSEEEWAQTKQLVEEFQTAGGVGERLQKGLERRARKMENWLSDWWLKTAYLQYRQPLVIYSSPGVMLPKQDFVDRQGQLRFAAKLIEGVLDFKAMIDNETLPVEYLGGKPLCMNQYYQILSSCRVPGPKQDLVTKFSRTKKPPMHITVVHNYQFFELDVYHSDGTPLTSDQIFMQLEKVWNSSLQTNKEPVGILTSNHRNSWAKAYSTLIKDKVNRESVHSIQRSIFTVCLDAPMPRVSEDTYRSQVAGQMLHGGGSKLNSGNRWFDKTLQFIVAEDGACGLIYEHAAAEGPPIVSLLDHVIEFTKRPELVRSPMVPLPMPKKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKDFPKSEKLSPDAFIQMALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFVKAMDDPNVTEHEKVELLRKAVQAHRAYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFNLSTSQVPAKTDCVMFFGPVVPDGYGVCYNPMETHINFSVSAYNSCAETNAVHLAHYLEKALLDMRALLQSHPRAKL", "length": 626, "header": "tr|A0A3Q1LYY4-1|A0A3Q1LYY4_BOVIN Isoform 1 of Carnitine O-acetyltransferase OS=Bos taurus OX=9913 GN=CRAT PE=1 SV=1 CANONICAL=A0A3Q1LYY4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LYY4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4/entry", "sequence": { "sequence": "MENGQQKEKVKPLGLLKPSSLMKVSSRFKAHQDSLPRLPVPPLQQTLDHYLKALQPIVSEEEWAQTKQLVEEFQTAGGVGERLQKGLERRARKMENWLSDWWLKTAYLQYRQPLVIYSSPGVMLPKQDFVDRQGQLRFAAKLIEGVLDFKAMIDNETLPVEYLGGKPLCMNQYYQILSSCRVPGPKQDLVTKFSRTKKPPMHITVVHNYQFFELDVYHSDGTPLTSDQIFMQLEKVWNSSLQTNKEPVGILTSNHRNSWAKAYSTLIKDKVNRESVHSIQRSIFTVCLDAPMPRVSEDTYRSQVAGQMLHGGGSKLNSGNRWFDKTLQFIVAEDGACGLIYEHAAAEGPPIVSLLDHVIEFTKRPELVRSPMVPLPMPKKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKDFPKSEKLSPDAFIQMALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFVKAMDDPNVTEHEKVELLRKAVQAHRAYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFNLSTSQVPAKTDCVMFFGPVVPDGYGVCYNPMETHINFSVSAYNSCAETNAVHLAHYLEKALLDMRALLQSHPRAKL", "length": 626, "header": "tr|A0A3Q1LYY4-1|A0A3Q1LYY4_BOVIN Isoform 1 of Carnitine O-acetyltransferase OS=Bos taurus OX=9913 GN=CRAT PE=1 SV=1 CANONICAL=A0A3Q1LYY4-1" }, "locus": { "chromosome": "11", "start_pos": 99570547, "end_pos": 99560232, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079641.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079641.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060872.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060872.1" } ] } }, { "isoform_ac": "A0A3Q1M201-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M201/entry", "sequence": { "sequence": "MLAFAARTVVSSRFKAHQDSLPRLPVPPLQQTLDHYLKALQPIVSEEEWAQTKQLVEEFQTAGGVGERLQKGLERRARKMENWLSDWWLKTAYLQYRQPLVIYSSPGVMLPKQDFVDRQGQLRFAAKLIEGVLDFKAMIDNETLPVEYLGGKPLCMNQYYQILSSCRVPGPKQDLVTKFSRTKKPPMHITVVHNYQFFELDVYHSDGTPLTSDQIFMQLEKVWNSSLQTNKEPVGILTSNHRNSWAKAYSTLIKDKVNRESVHSIQRSIFTVCLDAPMPRVSEDTYRSQVAGQMLHGGGSKLNSGNRWFDKTLQFIVAEDGACGLIYEHAAAEGPPIVSLLDHVIEFTKRPELVRSPMVPLPMPKKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKDFPKSEKLSPDAFIQMALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFVKAMDDPNVTEHEKVELLRKAVQAHRAYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFNLSTSQVPAKTDCVMFFGPVVPDGYGVCYNPMETHINFSVSAYNSCAETNAVHLAHYLEKALLDMRALLQSHPRAKL", "length": 612, "header": "tr|A0A3Q1M201-1|A0A3Q1LYY4_BOVIN Computationally mapped isoform of Carnitine O-acetyltransferase OS=Bos taurus OX=9913 GN=CRAT PE=1 SV=2 CANONICAL=A0A3Q1LYY4-1" }, "locus": { "chromosome": "11", "start_pos": 99572396, "end_pos": 99560232, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072616.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072616.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063784.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063784.2" } ] } }, { "isoform_ac": "A0AAA9S709-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S709/entry", "sequence": { "sequence": "MLAFAARTVVKPLGLLKPSSLMKVSSRFKAHQDSLPRLPVPPLQQTLDHYLKALQPIVSEEEWAQTKQLVEEFQTAGGVGERLQKGLERRARKMENWLSDWWLKTAYLQYRQPLVIYSSPGVMLPKQDFVDRQGQLRFAAKLIEGVLDFKAMIDNETLPVEYLGGKPLCMNQYYQILSSCRVPGPKQDLVTKFSRTKKPPMHITVVHNYQFFELDVYHSDGTPLTSDQIFMQLEKVWNSSLQTNKEPVGILTSNHRNSWAKAYSTLIKDKVNRESVHSIQRSIFTVCLDAPMPRVSEDTYRSQVAGQMLHGGGSKLNSGNRWFDKTLQFIVAEDGACGLIYEHAAAEGPPIVSLLDHVIEFTKRPELVRSPMVPLPMPKKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKDFPKSEKLSPDAFIQMALQLAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFNLSTSQVPAKTDCVMFFGPVVPDGYGVCYNPMETHINFSVSAYNSCAETNAVHLAHYLEKALLDMRALLQSHPRAKL", "length": 551, "header": "tr|A0AAA9S709-1|A0A3Q1LYY4_BOVIN Computationally mapped isoform of Carnitine O-acetyltransferase OS=Bos taurus OX=9913 GN=CRAT PE=1 SV=1 CANONICAL=A0A3Q1LYY4-1" }, "locus": { "chromosome": "11", "start_pos": 99572396, "end_pos": 99560232, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122505.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122505.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081784.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081784.1" } ] } }, { "isoform_ac": "F6QH77-1", "url": "https://www.uniprot.org/uniprotkb/F6QH77/entry", "sequence": { "sequence": "MLAFAARTVVKPLGLLKPSSLMKVSSRFKAHQDSLPRLPVPPLQQTLDHYLKALQPIVSEEEWAQTKQLVEEFQTAGGVGERLQKGLERRARKMENWLSDWWLKTAYLQYRQPLVIYSSPGVMLPKQDFVDRQGQLRETLPVEYLGGKPLCMNQYYQILSSCRVPGPKQDLVTKFSRTKKPPMHITVVHNYQFFELDVYHSDGTPLTSDQIFMQLEKVWNSSLQTNKEPVGILTSNHRNSWAKAYSTLIKDKVNRESVHSIQRSIFTVCLDAPMPRVSEDTYRSQVAGQMLHGGGSKLNSGNRWFDKTLQFIVAEDGACGLIYEHAAAEGPPIVSLLDHVIEFTKRPELVRSPMVPLPMPKKLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKDFPKSEKLSPDAFIQMALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFVKAMDDPNVTEHEKVELLRKAVQAHRAYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFNLSTSQVPAKTDCVMFFGPVVPDGYGVCYNPMETHINFSVSAYNSCAETNAVHLAHYLEKALLDMRALLQSHPRAKL", "length": 608, "header": "tr|F6QH77-1|A0A3Q1LYY4_BOVIN Computationally mapped isoform of Carnitine O-acetyltransferase OS=Bos taurus OX=9913 GN=CRAT PE=1 SV=1 CANONICAL=A0A3Q1LYY4-1" }, "locus": { "chromosome": "11", "start_pos": 99572396, "end_pos": 99560232, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002513.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002513.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002513.6", "url": "https://www.ensembl.org/id/ENSBTAP00000002513.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-389887", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389887", "resource": "Reactome", "description": "Beta-oxidation of pristanoyl-CoA" }, { "id": "R-BTA-70895", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70895", "resource": "Reactome", "description": "Branched-chain amino acid catabolism" }, { "id": "R-BTA-9033241", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033241", "resource": "Reactome", "description": "Peroxisomal protein import" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ], "pmid": "" }, { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "fatty acid beta-oxidation using acyl-CoA oxidase", "id": "GO:0033540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033540", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ], "pmid": "" }, { "name": "short-chain fatty acid metabolic process", "id": "GO:0046459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046459", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ], "pmid": "" }, { "name": "medium-chain fatty acid metabolic process", "id": "GO:0051791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051791", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ], "pmid": "" }, { "name": "carnitine metabolic process, CoA-linked", "id": "GO:0019254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019254", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ], "pmid": "" }, { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "acyl-CoA oxidase activity", "id": "GO:0003997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003997", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ], "pmid": "" }, { "name": "carnitine O-octanoyltransferase activity", "id": "GO:0008458", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008458", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ], "pmid": "" }, { "name": "carnitine O-acetyltransferase activity", "id": "GO:0004092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004092", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ], "pmid": "" }, { "name": "O-acetyltransferase activity", "id": "GO:0016413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016413", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ], "pmid": "" }, { "name": "carnitine O-acyltransferase activity", "id": "GO:0016406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016406", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYY4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 238, "end_pos": 240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 399, "end_pos": 401, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 550, "end_pos": 552, "annotation": "n_glycosylation_sequon" }, { "start_pos": 586, "end_pos": 588, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17177", "name": "", "equation": "octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KJB7-1", "F1N1M7-1", "O19094-1", "A0A3Q1LYY4-1" ], "evidence": [ { "id": "17177", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17177" } ] }, { "id": "21136", "name": "", "equation": "(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LYY4-1" ], "evidence": [ { "id": "21136", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21136" } ] }, { "id": "44828", "name": "", "equation": "decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KJB7-1", "F1N1M7-1", "A0A3Q1LYY4-1" ], "evidence": [ { "id": "44828", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44828" } ] }, { "id": "44860", "name": "", "equation": "4,8-dimethylnonanoyl-CoA + (R)-carnitine = O-4,8-dimethylnonanoyl-(R)-carnitine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O19094-1", "A0A3Q1LYY4-1", "Q2KJB7-1", "F1N1M7-1" ], "evidence": [ { "id": "44860", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44860" } ] }, { "id": "44972", "name": "", "equation": "hexanoyl-CoA + (R)-carnitine = O-hexanoyl-(R)-carnitine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LYY4-1" ], "evidence": [ { "id": "44972", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44972" } ] }, { "id": "44976", "name": "", "equation": "propanoyl-CoA + (R)-carnitine = O-propanoyl-(R)-carnitine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LYY4-1" ], "evidence": [ { "id": "44976", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44976" } ] }, { "id": "44980", "name": "", "equation": "butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LYY4-1" ], "evidence": [ { "id": "44980", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44980" } ] }, { "id": "44984", "name": "", "equation": "3-methylbutanoyl-CoA + (R)-carnitine = O-3-methylbutanoyl-(R)-carnitine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LYY4-1" ], "evidence": [ { "id": "44984", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44984" } ] }, { "id": "44988", "name": "", "equation": "2-methylpropanoyl-CoA + (R)-carnitine = O-isobutanoyl-(R)-carnitine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LYY4-1" ], "evidence": [ { "id": "44988", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44988" } ] }, { "id": "44992", "name": "", "equation": "2-methylbutanoyl-CoA + (R)-carnitine = O-2-methylbutanoyl-(R)-carnitine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LYY4-1" ], "evidence": [ { "id": "44992", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44992" } ] }, { "id": "44996", "name": "", "equation": "acetoacetyl-CoA + (R)-carnitine = O-3-oxobutanoyl-(R)-carnitine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LYY4-1" ], "evidence": [ { "id": "44996", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44996" } ] }, { "id": "45000", "name": "", "equation": "3-hydroxybutanoyl-CoA + (R)-carnitine = O-3-hydroxybutanoyl-(R)-carnitine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LYY4-1" ], "evidence": [ { "id": "45000", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45000" } ] }, { "id": "45004", "name": "", "equation": "2,6-dimethylheptanoyl-CoA + (R)-carnitine = O-2,6-dimethylheptanoyl-(R)-carnitine + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LYY4-1" ], "evidence": [ { "id": "45004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45004" } ] }, { "id": "R-BTA-390284", "name": "propionyl-CoA + carnitine => propionylcarnitine + CoASH", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal matrix", "input_participant_list": [ "R-ALL-192314" ], "output_participant_list": [ "R-ALL-390274" ], "enzyme_list": [ "A0A3Q1LYY4-1" ], "evidence": [ { "id": "R-BTA-390284", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390284" } ] }, { "id": "R-BTA-390291", "name": "acetyl-CoA + carnitine => acetylcarnitine + CoASH", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal matrix", "input_participant_list": [], "output_participant_list": [ "R-ALL-390287" ], "enzyme_list": [ "A0A3Q1LYY4-1" ], "evidence": [ { "id": "R-BTA-390291", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-390291" } ] }, { "id": "R-BTA-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LQH8-1", "Q3SZP5-1", "A0AAA9TBR3-1", "A0AAA9TZC7-1", "A0A3Q1LS67-1", "A0AAA9SXG3-1", "F1MYR5-1", "O19094-1", "Q29448-1", "Q3SX23-1", "F1MQP2-1", "F1MVP8-1", "A0AAA9TYP4-1", "Q24K02-1", "F6RWU6-1", "A0A3Q1LTU2-1", "A0A3Q1LYY4-1", "A0AAA9TW47-1", "A0AAA9SND8-1", "F1MV74-1", "P00432-1", "A0A140T8A5-1", "Q29RU9-1", "Q3ZBW2-1", "A0AAA9SC38-1", "A0AAA9SAI8-1" ], "evidence": [ { "id": "R-BTA-9033235", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033235" } ] }, { "id": "R-BTA-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LQH8-1", "Q3SZP5-1", "A0AAA9TBR3-1", "A0AAA9TZC7-1", "A0A3Q1LS67-1", "A0AAA9SXG3-1", "F1MYR5-1", "O19094-1", "Q29448-1", "Q3SX23-1", "F1MQP2-1", "F1MVP8-1", "A0AAA9TYP4-1", "Q24K02-1", "F6RWU6-1", "A0A3Q1LTU2-1", "A0A3Q1LYY4-1", "A0AAA9TW47-1", "A0AAA9SND8-1", "F1MV74-1", "P00432-1", "A0A140T8A5-1", "Q29RU9-1", "Q3ZBW2-1", "A0AAA9SC38-1", "A0AAA9SAI8-1" ], "evidence": [ { "id": "R-BTA-9033236", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9033236" } ] }, { "id": "R-BTA-9971123", "name": "CRAT transfers ISB to CAR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-201023" ], "output_participant_list": [ "R-ALL-9971124" ], "enzyme_list": [ "A0A3Q1LYY4-1" ], "evidence": [ { "id": "R-BTA-9971123", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9971123" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-192314", "participant_name": "propionyl CoA [peroxisomal matrix]", "crossref": [ { "id": "57392", "database": "ChEBI", "url": "" }, { "id": "ZINC000008551120", "database": "ZINC", "url": "" }, { "id": "C00100", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-201023", "participant_name": "CAR [mitochondrial matrix]", "crossref": [ { "id": "16347", "database": "ChEBI", "url": "" }, { "id": "C00318", "database": "COMPOUND", "url": "" }, { "id": "4780", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000003079340", "database": "ZINC", "url": "" }, { "id": "HMDB0000062", "database": "HMDB Metabolite", "url": "" }, { "id": "C00487", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-390274", "participant_name": "Propionylcarnitine [peroxisomal matrix]", "crossref": [ { "id": "HMDB0000824", "database": "HMDB Metabolite", "url": "" }, { "id": "53210", "database": "ChEBI", "url": "" }, { "id": "ZINC000001529576", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-390287", "participant_name": "ACAR [peroxisomal matrix]", "crossref": [ { "id": "57589", "database": "ChEBI", "url": "" }, { "id": "ZINC000003644165", "database": "ZINC", "url": "" }, { "id": "HMDB0000201", "database": "HMDB Metabolite", "url": "" }, { "id": "4520", "database": "Guide to Pharmacology - Ligands", "url": "" } ] }, { "participant_id": "R-ALL-9971124", "participant_name": "ISB-CAR [mitochondrial matrix]", "crossref": [ { "id": "84838", "database": "ChEBI", "url": "" }, { "id": "HMDB0000736", "database": "HMDB Metabolite", "url": "" }, { "id": "ZINC000005359087", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T8A5", "gene_name": "IDH1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] } ] }, { "uniprot_ac": "A0A3Q1LQH8", "gene_name": "GNPAT", "activity": [ { "ec_number": "2.3.1.42", "activity": "dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA.", "evidence": [ { "id": "A0A3Q1LQH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQH8" } ] }, { "ec_number": "2.3.1.42", "activity": "", "evidence": [ { "id": "A0A3Q1LQH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LS67", "gene_name": "ECH1", "activity": [ { "ec_number": "5.3.3.21", "activity": "a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA.", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] }, { "ec_number": "5.3.3.21", "activity": "", "evidence": [ { "id": "A0A3Q1LS67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LS67" } ] } ] }, { "uniprot_ac": "A0A3Q1LTU2", "gene_name": "PEX10", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LTU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTU2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LTU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LYY4", "gene_name": "CRAT", "activity": [ { "ec_number": "2.3.1.137", "activity": "octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA.", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] }, { "ec_number": "2.3.1.7", "activity": "(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA.", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] }, { "ec_number": "2.3.1.137", "activity": "", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] }, { "ec_number": "2.3.1.7", "activity": "", "evidence": [ { "id": "A0A3Q1LYY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYY4" } ] } ] }, { "uniprot_ac": "A0AAA9SAI8", "gene_name": "TYSND1", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "A0AAA9SAI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAI8" } ] } ] }, { "uniprot_ac": "A0AAA9SC38", "gene_name": "HAO1", "activity": [ { "ec_number": "1.1.3.15", "activity": "glycolate + O2 = glyoxylate + H2O2.", "evidence": [ { "id": "A0AAA9SC38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38" } ] }, { "ec_number": "1.1.3.15", "activity": "", "evidence": [ { "id": "A0AAA9SC38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC38" } ] } ] }, { "uniprot_ac": "A0AAA9SND8", "gene_name": "EHHADH", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+).", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "4.2.1.17", "activity": "(3S)-3-hydroxyadipyl-CoA = (E)-2,3-didehydroadipoyl-CoA + H2O.", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "4.2.1.17", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "A0AAA9SND8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SND8" } ] } ] }, { "uniprot_ac": "A0AAA9SXG3", "gene_name": "DAO", "activity": [ { "ec_number": "1.4.3.3", "activity": "D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + H2O2 + NH4(+).", "evidence": [ { "id": "A0AAA9SXG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG3" } ] }, { "ec_number": "1.4.3.3", "activity": "", "evidence": [ { "id": "A0AAA9SXG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG3" } ] } ] }, { "uniprot_ac": "A0AAA9TBR3", "gene_name": "PAOX", "activity": [ { "ec_number": "1.5.3.13", "activity": "N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2.", "evidence": [ { "id": "A0AAA9TBR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ] }, { "ec_number": "1.5.3.13", "activity": "", "evidence": [ { "id": "A0AAA9TBR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR3" } ] } ] }, { "uniprot_ac": "A0AAA9TW47", "gene_name": "GSTK1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] } ] }, { "uniprot_ac": "A0AAA9TYP4", "gene_name": "PECR", "activity": [ { "ec_number": "1.3.1.38", "activity": "a (2E)-enoyl-CoA + NADPH + H(+) = a 2,3-saturated acyl-CoA + NADP(+).", "evidence": [ { "id": "A0AAA9TYP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYP4" } ] }, { "ec_number": "1.3.1.38", "activity": "", "evidence": [ { "id": "A0AAA9TYP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYP4" } ] } ] }, { "uniprot_ac": "A0AAA9TZC7", "gene_name": "ECI2", "activity": [ { "ec_number": "5.3.3.8", "activity": "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA.", "evidence": [ { "id": "A0AAA9TZC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZC7" } ] }, { "ec_number": "5.3.3.8", "activity": "", "evidence": [ { "id": "A0AAA9TZC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZC7" } ] } ] }, { "uniprot_ac": "F1MQP2", "gene_name": "SLC27A2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MQP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQP2" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "F1MQP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQP2" } ] } ] }, { "uniprot_ac": "F1MV74", "gene_name": "SCP2", "activity": [ { "ec_number": "2.3.1.176", "activity": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA.", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.16", "activity": "an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.155", "activity": "tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA.", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.155", "activity": "", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] }, { "ec_number": "2.3.1.176", "activity": "", "evidence": [ { "id": "F1MV74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV74" } ] } ] }, { "uniprot_ac": "F1MVP8", "gene_name": "HACL1", "activity": [ { "ec_number": "4.1.2.63", "activity": "2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA.", "evidence": [ { "id": "F1MVP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVP8" } ] }, { "ec_number": "4.1.2.63", "activity": "", "evidence": [ { "id": "F1MVP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVP8" } ] } ] }, { "uniprot_ac": "F1MYR5", "gene_name": "NOS2", "activity": [ { "ec_number": "1.14.13.39", "activity": "2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O.", "evidence": [ { "id": "F1MYR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYR5" } ] }, { "ec_number": "1.14.13.39", "activity": "", "evidence": [ { "id": "F1MYR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYR5" } ] } ] }, { "uniprot_ac": "F1N1M7", "gene_name": "CPT2", "activity": [ { "ec_number": "2.3.1.21", "activity": "(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA.", "evidence": [ { "id": "F1N1M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1M7" } ] }, { "ec_number": "2.3.1.21", "activity": "", "evidence": [ { "id": "F1N1M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1M7" } ] } ] }, { "uniprot_ac": "F6RWU6", "gene_name": "ACOT8", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.3", "activity": "succinyl-CoA + H2O = succinate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.27", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "F6RWU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RWU6" } ] } ] }, { "uniprot_ac": "O19094", "gene_name": "CROT", "activity": [ { "ec_number": "2.3.1.137", "activity": "octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA.", "evidence": [ { "id": "O19094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O19094" } ] }, { "ec_number": "2.3.1.137", "activity": "", "evidence": [ { "id": "O19094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O19094" } ] } ] }, { "uniprot_ac": "P00432", "gene_name": "CAT", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = O2 + 2 H2O.", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P00432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00432" } ] } ] }, { "uniprot_ac": "Q24K02", "gene_name": "IDE", "activity": [ { "ec_number": "3.4.24.56", "activity": "Degradation of insulin, glucagon and other polypeptides. No action on proteins.", "evidence": [ { "id": "Q24K02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K02" } ] }, { "ec_number": "3.4.24.56", "activity": "", "evidence": [ { "id": "Q24K02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K02" } ] } ] }, { "uniprot_ac": "Q29448", "gene_name": "HMGCL", "activity": [ { "ec_number": "4.1.3.4", "activity": "(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.", "evidence": [ { "id": "Q29448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29448" } ] }, { "ec_number": "4.1.3.4", "activity": "", "evidence": [ { "id": "Q29448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29448" } ] } ] }, { "uniprot_ac": "Q29RU9", "gene_name": "PIPOX", "activity": [ { "ec_number": "1.5.3.1", "activity": "sarcosine + O2 + H2O = formaldehyde + glycine + H2O2.", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] }, { "ec_number": "1.5.3.7", "activity": "L-pipecolate + O2 = L-1-piperideine-6-carboxylate + H2O2 + H(+).", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] }, { "ec_number": "1.5.3.1", "activity": "", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] }, { "ec_number": "1.5.3.7", "activity": "", "evidence": [ { "id": "Q29RU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RU9" } ] } ] }, { "uniprot_ac": "Q2KJB7", "gene_name": "CPT2", "activity": [ { "ec_number": "2.3.1.21", "activity": "(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA.", "evidence": [ { "id": "Q2KJB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJB7" } ] }, { "ec_number": "2.3.1.21", "activity": "", "evidence": [ { "id": "Q2KJB7", "database": "UniProtKB", "url": 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LZ45-1", "uniprot_ac": "A0A3Q1LZ45", "uniprot_id": "A0A3Q1LZ45_BOVIN", "mass": { "chemical_mass": 92965.0, "monoisotopic_mass": 92965.0 }, "refseq": {}, "gene_names": [ { "name": "LOC112445824", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZ45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ45" } ] } ], "protein_names": [ { "name": "LRRCT domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZ45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ45/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ45", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ45" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC112445824", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ45", "locus": {} } ], "crossref": [ { "id": "A0A3Q1LZ45", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LZ45", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054414", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054414", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EPSMFIH", "url": "https://omabrowser.org/oma/group/EPSMFIH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45773", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45773", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45773:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45773:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LZ45", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ45-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ45-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSGTQRQKTLISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLQLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKAPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPSNAKKLHVNGNSIKDVDISDFTEFEGLDLLHLGSNQITAIKGDVFRNLTNLRRLYLNGNQIERLYPEMFSGLHNLQYLYLEYNLIKEILAGTFDSMPNLQLLYLNNNLLKSLLNLRNNKFMYLPVSGVLDQLQALTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVMKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPECGSMQLQLRKHDHKTNKKDGLGTEAFIPQTIEQMSKSHTCSLKDSETGFMFSDPPGQKVMMRNVTDKEKDVLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQDKKTKKSLIGGNHSKIVVEQRKSSEYFELKAKLQSSPDYLQVLEEQTALNKI", "length": 824, "header": "tr|A0A3Q1LZ45-1|A0A3Q1LZ45_BOVIN Isoform 1 of LRRCT domain-containing protein OS=Bos taurus OX=9913 GN=LOC112445824 PE=3 SV=2 CANONICAL=A0A3Q1LZ45-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZ45-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ45/entry", "sequence": { "sequence": "MLSGTQRQKTLISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLQLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKAPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPSNAKKLHVNGNSIKDVDISDFTEFEGLDLLHLGSNQITAIKGDVFRNLTNLRRLYLNGNQIERLYPEMFSGLHNLQYLYLEYNLIKEILAGTFDSMPNLQLLYLNNNLLKSLLNLRNNKFMYLPVSGVLDQLQALTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVMKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPECGSMQLQLRKHDHKTNKKDGLGTEAFIPQTIEQMSKSHTCSLKDSETGFMFSDPPGQKVMMRNVTDKEKDVLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQDKKTKKSLIGGNHSKIVVEQRKSSEYFELKAKLQSSPDYLQVLEEQTALNKI", "length": 824, "header": "tr|A0A3Q1LZ45-1|A0A3Q1LZ45_BOVIN Isoform 1 of LRRCT domain-containing protein OS=Bos taurus OX=9913 GN=LOC112445824 PE=3 SV=2 CANONICAL=A0A3Q1LZ45-1" }, "locus": { "chromosome": "NKLS02002208.1", "start_pos": 1756314, "end_pos": 1752928, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073929.1", "url": "https://www.ensembl.org/id/ENSBTAT00000073929.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062891.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062891.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IYE6-1", "protein_name": "SLIT and NTRK-like protein 4 isoform X1", "gene_name": "slitrk4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLLLVLLAFSISGSFCDLDSDLRAETCSACSCMSIENVLYVNCEKITVYRPTQLHPPASSLYHLNFQNNLLYILYPNSFVNFTHAVSLQLGNNKLQNIEGGAFVGLSALKQLHLNNNELKELRADTFRGIENLEYLQADYNLIKFIEKGAFNKLHKLKVLILNDNLIQSLPENIFRFASLTHLDIRGNRIQKLPYLGVLEHIGRIVELQLDDNPWNCTCDLLPLKAWLENMPYNIFIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRMPPSQPEGGLTMSNVAPSTIAPLVTKAPKTTNPSKIYGNGIVAGNPAGKNGQIVSYQTRIPPLSCPQPCTCKAHPSDFGISVSCQERNIQSLADLIPKPPNAKKLHLSGNYIRDISPTDFQGFEGLDLLHLGSNQISTVQKGVFANLTNLRRLYLNGNQLEQLHPEMFLGLSNLQYLYLEYNAIKEVLAGTFDSMPNLQLLYLNNNVLRSLPAYIFAGVSLARLNLKNNHFMTLPVSGVLDQLKSLTQIDLDGNPWECSCDLVALKLWLEKLNEGVAAKGVKCASPVQFSNIELRELKNEIMCPKLIARPPFILTSATPVLTSLSPAGVGKAPPSGPVPLSIMILSILVVLILTVFVAFCLLVFVLRRNKKPAGRQEGLGNQECGSMPLQIRRHNHKSNKDDLGGETFIPQTIEHMSKAHTCGIRDSDSGYKFIDSERQKMMLRNSADQDKDSLSLDPRKRLSTIDELDEFLPGRDTMFLHNFMESKKDFSSIGVSGFEIRYPEKPHDKKMKKSLIGGNHSKIVIEQRKSDYYELKAKMGTPDYLQVLEEQTALSKF", "length": 830 }, "evidence": [ { "id": "A0A3Q1LZ45", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ45/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8I6AET5-1", "protein_name": "SLIT and NTRK-like family, member 4", "gene_name": "Slitrk4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFLWLFLIVSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFVNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGFTTPNGHTTQTTLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELTPKPLNAKKLHVNGNNIKDVDISDFTEFEGLDLLHLGSNQITAIKGEVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEILAGTFDSLPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITLTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPECGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVMMRSAADKDKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQDKKNKKSLIGGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI", "length": 836 }, "evidence": [ { "id": "A0A3Q1LZ45", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ45/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RQ64-1", "protein_name": "SLIT and NTRK like family member 4", "gene_name": "SLITRK4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFLWLFLILSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLQLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENSYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKGLSTRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPFNAKKLHVNGNSIKDVDISDFAEFEGLDLLHLGSNQIAAIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEILAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELRCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPIPAVTFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLANPECGSMQLQLRKHEHKSNKKDGLATEAFIPQTIEQMSKSHTCGLKESETGFMFADPPGQKVMMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQQDKKTKKSLIGGNHSKIVVEQRKSSEYFELKAKLQSSPDYLQVLEEQTALNKI", "length": 838 }, "evidence": [ { "id": "A0A3Q1LZ45", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ45/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q810B8-1", "protein_name": "SLIT and NTRK-like protein 4", "gene_name": "Slitrk4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFLWLFLIVSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFVNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQQENGFTTPNGHTTQTTLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPVPCFCKTHPSDLGLSVNCQEKNIQSMSELTPKPLNAKKLHVNGNNIKDVDISDFTEFEGLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEILAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSATFTSPAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNSECGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVMMRNAADKDKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQQDKKNKKSLIGGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI", "length": 837 }, "evidence": [ { "id": "A0A3Q1LZ45", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ45/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IW52-1", "protein_name": "SLIT and NTRK-like protein 4", "gene_name": "SLITRK4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFLWLFLILSALISSTNADSDISVEICNVCSCVSVENVLYVNCEKVSVYRPNQLKPPWSNFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPKLLNKPSAPFTSPAPAITFTTPLGPIRSPPGGPVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKKDGLSTEAFIPQTIEQMSKSHTCGLKESETGFMFSDPPGQKVVMRNVADKEKDLLHVDTRKRLSTIDELDELFPSRDSNVFIQNFLESKKEYNSIGVSGFEIRYPEKQPDKKSKKSLIGGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNKI", "length": 837 }, "evidence": [ { "id": "A0A3Q1LZ45", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ45/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ45", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ45" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ45", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ45" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "axonogenesis", "id": "GO:0007409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007409", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ45", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ45" } ], "pmid": "" }, { "name": "positive regulation of synapse assembly", "id": "GO:0051965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051965", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ45", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ45" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 710, "end_pos": 712, "annotation": "n_glycosylation_sequon" }, { "start_pos": 784, "end_pos": 786, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LZ45-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 824, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LZ45-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LZ45" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LZ45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ45" }, { "id": "SM00082", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00082" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRRCT", "eco_id": "ECO_0000259", "start_pos": 212, "end_pos": 262, "start_aa": "Asn", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 215, "end_pos": 217 }, { "start_pos": 324, "end_pos": 326 }, { "start_pos": 422, "end_pos": 424 }, { "start_pos": 710, "end_pos": 712 }, { "start_pos": 784, "end_pos": 786 }, { "start_pos": 80, "end_pos": 82 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LZ87-1", "uniprot_ac": "A0A3Q1LZ87", "uniprot_id": "A0A3Q1LZ87_BOVIN", "mass": { "chemical_mass": 84818.0, "monoisotopic_mass": 84818.0 }, "refseq": { "ac": "XP_005217920", "name": "ABC-type oligopeptide transporter ABCB9 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217920" }, "gene_names": [ { "name": "ABCB9", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZ87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87" } ] }, { "name": "ABCB9", "type": "synonym", "evidence": [ { "id": "XP_005217920", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217920" } ] } ], "protein_names": [ { "name": "ABC-type oligopeptide transporter ABCB9", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZ87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87/entry#names_and_taxonomy" } ] }, { "name": "7.4.2.6", "type": "synonym", "evidence": [ { "id": "A0A3Q1LZ87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87/entry#names_and_taxonomy" } ] }, { "name": "ABC-type oligopeptide transporter ABCB9 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005217920", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217920" } ] }, { "name": "ATP-binding cassette sub-family B member 9", "type": "synonym", "evidence": [ { "id": "A0A3Q1LZ87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87/entry#names_and_taxonomy" } ] }, { "name": "ATP-binding cassette transporter 9", "type": "synonym", "evidence": [ { "id": "A0A3Q1LZ87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87/entry#names_and_taxonomy" } ] }, { "name": "TAP-like protein", "type": "synonym", "evidence": [ { "id": "A0A3Q1LZ87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with the same affinity. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.", "evidence": [ { "database": "UniProtKB", "id": "E1BKR0", "url": "https://www.uniprot.org/uniprotkb/E1BKR0#function" }, { "database": "UniProtKB", "id": "ARBA00055204", "url": "https://www.uniprot.org/uniprotkb/ARBA00055204#function" }, { "database": "UniProtKB", "id": "A0A3Q1M884", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M884#function" }, { "database": "UniProtKB", "id": "A0A3Q1LZ87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87#function" }, { "database": "UniProtKB", "id": "A0AAA9SZM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZM9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABCB9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87", "locus": { "chromosome": "17", "start_pos": 52603871, "end_pos": 52561978, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008464", "url": "https://www.ensembl.org/id/ENSBTAG00000008464" } ] } } ], "crossref": [ { "id": "A0A3Q1LZ87", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LZ87", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008464", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008464", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03248", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03248", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18784", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18784", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529923", "url": "https://www.ncbi.nlm.nih.gov/gene/529923", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529923", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529923", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CRLYEPQ", "url": "https://omabrowser.org/oma/group/CRLYEPQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZ87", "url": "https://www.orthodb.org/?gene=A0A3Q1LZ87", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BKR0", "url": "https://www.orthodb.org/?gene=E1BKR0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43394:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43394:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00664", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00664", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005217920", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217920", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "14429", "url": "https://www.rhea-db.org/rhea/14429", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LZ87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ87-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M884", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M884", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M884-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M884-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKR0", "url": "https://www.uniprot.org/uniprotkb/E1BKR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BKR0-1", "url": "https://www.uniprot.org/uniprotkb/E1BKR0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLCKAVVVTLAFMSLDIGMTTAIYILSHLDRSLLEDIRHFNIFDSVLDLWAACVYRSCLLLGATIGVAKNSTLGPRRLRASWTVIALVCLFGGIYTMVKLLLFSEVRKPVRDPWFWALFVWTYISLTASFLLWWLLSTVRPDTKALGRGAGAEGEGEGEGFPGEDRPAPEQASGATLQKLLSYTKPDIAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMEQFSAAVIVMCVLAIGSSFAAGIRGGIFTLIFARLNIRLRNRLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSDIYGKYYKRLSKEVQSALARASSTAEETISAMKTVRSFANEEEEAEVYSRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLISFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGQVLLDGKPIGAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFETVVEAAQKANAHGFIMELQDGYNTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYARLVQRQMLGLEPTGDFTAGHREPPGNGSHKA", "length": 770, "header": "tr|A0A3Q1LZ87-1|A0A3Q1LZ87_BOVIN Isoform 1 of ABC-type oligopeptide transporter ABCB9 OS=Bos taurus OX=9913 GN=ABCB9 PE=3 SV=1 CANONICAL=A0A3Q1LZ87-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZ87-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87/entry", "sequence": { "sequence": "MRLCKAVVVTLAFMSLDIGMTTAIYILSHLDRSLLEDIRHFNIFDSVLDLWAACVYRSCLLLGATIGVAKNSTLGPRRLRASWTVIALVCLFGGIYTMVKLLLFSEVRKPVRDPWFWALFVWTYISLTASFLLWWLLSTVRPDTKALGRGAGAEGEGEGEGFPGEDRPAPEQASGATLQKLLSYTKPDIAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMEQFSAAVIVMCVLAIGSSFAAGIRGGIFTLIFARLNIRLRNRLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSDIYGKYYKRLSKEVQSALARASSTAEETISAMKTVRSFANEEEEAEVYSRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLISFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGQVLLDGKPIGAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFETVVEAAQKANAHGFIMELQDGYNTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYARLVQRQMLGLEPTGDFTAGHREPPGNGSHKA", "length": 770, "header": "tr|A0A3Q1LZ87-1|A0A3Q1LZ87_BOVIN Isoform 1 of ABC-type oligopeptide transporter ABCB9 OS=Bos taurus OX=9913 GN=ABCB9 PE=3 SV=1 CANONICAL=A0A3Q1LZ87-1" }, "locus": { "chromosome": "17", "start_pos": 52602886, "end_pos": 52579294, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070992.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070992.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061010.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061010.1" } ] } }, { "isoform_ac": "A0A3Q1M884-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M884/entry", "sequence": { "sequence": "MRLCKAVVVTLAFMSLDIGMTTAIYILSHLDRSLLEDIRHFNIFDSVLDLWAACVYRSCLLLGATIGVAKNSTLGPRRLRASWTVIALVCLFGGIYTMVKLLLFSEVRKPVRDPWFWALFVWTYISLTASFLLWWLLSTVRPDTKALGRGAGAEGEGEGEGFPGEDRPAPEQASGATLQKLLSYTKPDIAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMEQFSAAVIVMCVLAIGSSFAAGIRGGIFTLIFARLNIRLRNRLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSDIYGKYYKRLSKEVQSALARASSTAEETISAMKTVRSFANEEEEAEVYSRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLISFIIYEFVLGDCMENVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGQVLLDGKPIGAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFETVVEAAQKANAHGFIMELQDGYNTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYARLVQRQMLGLEPTGDFTAGHREPPGNGSHKA", "length": 707, "header": "tr|A0A3Q1M884-1|A0A3Q1LZ87_BOVIN Computationally mapped isoform of ABC-type oligopeptide transporter ABCB9 OS=Bos taurus OX=9913 GN=ABCB9 PE=3 SV=2 CANONICAL=A0A3Q1LZ87-1" }, "locus": { "chromosome": "17", "start_pos": 52602886, "end_pos": 52579294, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070831.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070831.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066645.3", "url": "https://www.ensembl.org/id/ENSBTAP00000066645.3" } ] } }, { "isoform_ac": "A0AAA9SZM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZM9/entry", "sequence": { "sequence": "MRLCKAVVVTLAFMSLDIGMTTAIYILSHLDRSLLEDIRHFNIFDSVLDLWAACVYRSCLLLGATIGVAKNSTLGPRRLRASWTVIALVCLFGGIYTMVKLLLFSEASGATLQKLLSYTKPDIAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMEQFSAAVIVMCVLAIGSSFAAGIRGGIFTLIFARLNIRLRNRLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSDIYGKYYKRLSKEVQSALARASSTAEETISAMKTVRSFANEEEEAEVYSRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLISFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGQVLLDGKPIGAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFETVVEAAQKANAHGFIMELQDGYNTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYARLVQRQMLGLEPTGDFTAGHREPPGNGSHKA", "length": 704, "header": "tr|A0AAA9SZM9-1|A0A3Q1LZ87_BOVIN Computationally mapped isoform of ABC-type oligopeptide transporter ABCB9 OS=Bos taurus OX=9913 GN=ABCB9 PE=3 SV=1 CANONICAL=A0A3Q1LZ87-1" }, "locus": { "chromosome": "17", "start_pos": 52602886, "end_pos": 52579294, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128136.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128136.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089750.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089750.1" } ] } }, { "isoform_ac": "E1BKR0-1", "url": "https://www.uniprot.org/uniprotkb/E1BKR0/entry", "sequence": { "sequence": "MRLCKAVVVTLAFMSLDIGMTTAIYILSHLDRSLLEDIRHFNIFDSVLDLWAACVYRSCLLLGATIGVAKNSTLGPRRLRASWTVIALVCLFGGIYTMVKLLLFSEVRKPVRDPWFWALFVWTYISLTASFLLWWLLSTVRPDTKALGRGAGAEGEGEGEGFPGEDRPAPEQASGATLQKLLSYTKPDIAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMEQFSAAVIVMCVLAIGSSFAAGIRGGIFTLIFARLNIRLRNRLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSDIYGKYYKRLSKEVQSALARASSTAEETISAMKTVRSFANEEEEAEVYSRKLQQVYKLNRKEAAAYMYYVWGSGSVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGQVLLDGKPIGAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFETVVEAAQKANAHGFIMELQDGYNTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYARLVQRQMLGLEPTGDFTAGHREPPGNGSHKA", "length": 727, "header": "tr|E1BKR0-1|A0A3Q1LZ87_BOVIN Computationally mapped isoform of ABC-type oligopeptide transporter ABCB9 OS=Bos taurus OX=9913 GN=ABCB9 PE=3 SV=2 CANONICAL=A0A3Q1LZ87-1" }, "locus": { "chromosome": "17", "start_pos": 52602886, "end_pos": 52579294, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011137.7", "url": "https://www.ensembl.org/id/ENSBTAT00000011137.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011137.4", "url": "https://www.ensembl.org/id/ENSBTAP00000011137.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:529923", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529923", "resource": "KEGG Pathway" }, { "id": "R-BTA-382556", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "resource": "Reactome", "description": "ABC-family protein mediated transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A3B2-1", "protein_name": "ABC-type oligopeptide transporter ABCB9", "gene_name": "ABCB9", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRAWKAVASTLALSGADVVVTTLLYAHGRRGQDILQDLRHFNIFNSLLDIWGGCLYRSCVLLGATIGVATNTAYGPRRLRASRTFIAVVCLLMGIYMMVKLLLYSEVRRTIRDPWFWGLFAWTYVALVATFGLWQLLACVTSSREALGHGSESRTEAEESCDAPRDKREEAAGPTIHKLLSYTKPDAVFLGIASFFLLVAALGETFLPYYTGLAIDGIVVQKSMDRFSTAVLVMSLLAIGSSFAAGVRGGVFTLIFARLNIRLRNCLFRSLMSQEMSFFDENRTGDVISRLTSDTTIVSDLVSQNINIFLRNVVKATGVIFFMFSLSWKLSLVTFMGFPIIMLVSDIYGKYYKKLSKDVQNALAKANNTAEETISAMKTVRSFANEEAEANVYWQKLQQVYRLNKREALAYTYYVWSSGLTLLVVQVSILYYGGHLVISGQMTSGNLISFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRKPTMVNDGSLAPDHVDGKVEFRNVTFSYRTRSATQVLQNVSFTLHPGKVTALVGPSGSGKSSCVNILENFYPLQDGQVLLDGHPINMYDHKYLHSVISLVSQEPVLFARSIADNISYGLASASFESVVQAAQKANAHAFITELQDGYHTEAGEKGAQLSGGQKQRVAIARALIRTPPILILDEATSALDAESEHAIQQAIYGDLQNHTVLVIAHRLSTVEKAHNIIVLDKGRVVQQGSHKELMEEGGLYSKLVQRQILGLEAGSTDSHQPTARGDSAKAPGGLEGEFRIDHSLPAAAQDDCNNAAHK", "length": 794 }, "evidence": [ { "id": "A0A3Q1LZ87", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ87/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A3KGZ4-1", "protein_name": "ABC-type oligopeptide transporter ABCB9", "gene_name": "abcb9", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRVAVIVSCNLVFTLVDIVLTTVLYIHGSNIDIFSDETEDFDIHRSTVDLWGTVLIRVSLLFGASIGVFFNRRDGPRRVSNLGTLVALICLTNMTYALAKLLMLSEEGNLMYDPWFLSLFSWTCVAAIGVMIFWKILSQTPNAVSDREDSEDTERLVDETEDESEKSMKSGKEHTHSGATIGRLLSYCKKDSSLLSIAFFFLLLSAVCEAFIPYYTGQAIDGIVIQKSMDHFAKPMITLSVLALVSSIAIGFRGGVFSVTFARLNIRLRNLLFRSLMHQEIGFFDANHTGDITSRLTSDTTQVSDLISQNVNLFLRSFVKAVGIFIFMFGMSWKLSVVTIMGFPYIAVVSKLYGEYYKKLTKEVQTALAQANKVAEETISAMRTVRSFANEDQEGDMYYSRLQEMFVLNKKQAIAYACFMWSSYISELALQVAILFYGGHLVVTNQMSGGTLISFVIYELELGEALESISSVYTGLMQGVGAAEKVFEYIDRKPKHALNGQEAPETLEGQVEFNNVTFAYPSRPEMDVLKNVSFSLRPGQVTALVGPSGGGKSSCVCLLENFYAPQQGQVLVDGRPVNTYQHKYYHSKVALVAQEPVLFARTVQMNISYGVPEAPMEAVIRAAINANAHDFITGLSKGYDSGVGEKGTQLSGGQKQRVAIARALIRSPRILILDEATSALDSESEYIVQQALNNLMREHTVLVIAHRLSTVERADNILVIDKGSVVEQGPHAELMARGGLYCKLVQRQILGTEIDVDDKNPSPAPTWELKTEDKENAEDCSDTEYETRY", "length": 789 }, "evidence": [ { "id": "A0A3Q1LZ87", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ87/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1RFJ4-1", "protein_name": "ABC-type oligopeptide transporter ABCB9", "gene_name": "ABCB9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQLWKAVAVTLAFMSMDVGLTTAIYVLSHRDRSLLEDIRHFNIFDSVLDLWAACLYRSCLLLGATIGVAKNSALGPRRLRASWTVIALVCLFGGIYTMVKLLLFSEVRKPVRDPWFWALFVWTYLSLAASFLLWWLLSTVLPNAKALERGAGTEPEAEGFPREDQPPAEQASGATLQKLLSYTKPDIAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMEQFSTAVIVMCALAIGSSFAAGIRGGIFTLIFARLNIRLRNRLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSDIYGKYYKRLSKEVQNALARASSTAEETISAMKTVRSFANEEEEAEVYSRKLQQVYKLNRKEAAAYTYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLISFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGNLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRAISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYNTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLEPASDYTAGHQETPGNGNHKA", "length": 768 }, "evidence": [ { "id": "A0A3Q1LZ87", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ87/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3I4Y8-1", "protein_name": "ABC-type oligopeptide transporter ABCB9", "gene_name": "Abcb9", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRLWKAVVVTLAFVSMDVGVTTAIYAFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCLLLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALFVWTYISLAASFLLWGLLATVRSDAEALEPGTEGFHGEGGAPAEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDSIVIQKSMDQFSTAVVVVCLLAIGSSLAAGIRGGIFTLVFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQSALARASTTAEETISAMKTVRSFANEEEEAEVFLHKLQQVYKLNRKEAAAYMSYVWGSGLTLLVVQVSILYYGGHLVISGQMSSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLQGGRVLLDGKPIGAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQRHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLEHHSDYTASHNEPPSNTEHKA", "length": 762 }, "evidence": [ { "id": "A0A3Q1LZ87", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ87/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8RY46-1", "protein_name": "ABC transporter B family member 26, chloroplastic", "gene_name": "ABCB26", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAQQVLGCTSRPIRVSLHRCSVITTSDTIRRKNLRFVRNPRLSFSLQSSTRNYRLPSINCSTVNGAVAETAEYYEGEGDNVSLAEKIRQCIDFLRTILPGGSWWSFSDEVDGRFIAKPVTVWRALSRMWELVAEDRWVIFAAFSTLIVAALSEITIPHFLTASIFSAQSGDIAVFHRNVKLLVTLCVTSGICSGIRGCFFGIANMILVKRMRETLYSTLLFQDISFFDSQTVGDLTSRLGSDCQQVSRVIGNDLNMIFRNVLQGTGALIYLLILSWPLGLCTLVICCILAAVMFVYGMYQKKTAKLIQEITASANEVAQETYSLMRTVRVYGTEKQEFKRYNHWLQRLADISLRQSAAYGIWNWSFNTLYHATQIIAVLVGGLSILAGQITAEQLTKFLLYSEWLIYATWWVGDNLSSLMQSVGASEKVFQMMDLKPSDQFISKGTRLQRLTGHIEFVDVSFSYPSRDEVAVVQNVNISVHPGEVVAIVGLSGSGKSTLVNLLLQLYEPTSGQILLDGVPLKELDVKWLRQRIGYVGQEPKLFRTDISSNIKYGCDRNISQEDIISAAKQAYAHDFITALPNGYNTIVDDDLLSGGQKQRIAIARAILRDPRILILDEATSALDAESEHNVKGVLRSIGNDSATKRSVIVIAHRLSTIQAADRIVAMDSGRVVEMGSHKELLSKDGLYARLTKRQNDAVL", "length": 700 }, "evidence": [ { "id": "A0A3Q1LZ87", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ87/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9JJ59-1", "protein_name": "ABC-type oligopeptide transporter ABCB9", "gene_name": "Abcb9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLWKAVVVTLAFVSTDVGVTTAIYAFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCLLLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMAKLLLFSEVRRPIRDPWFWALFVWTYISLAASFLLWGLLATVRPDAEALEPGNEGFHGEGGAPAEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDSIVIQKSMDQFTTAVVVVCLLAIGSSLAAGIRGGIFTLVFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQSALARASTTAEETISAMKTVRSFANEEEEAEVFLRKLQQVYKLNRKEAAAYMSYVWGSGLTLLVVQVSILYYGGHLVISGQMSSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLQGGRVLLDGKPIGAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQRHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLEHPLDYTASHKEPPSNTEHKA", "length": 762 }, "evidence": [ { "id": "A0A3Q1LZ87", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ87/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NP78-1", "protein_name": "ABC-type oligopeptide transporter ABCB9", "gene_name": "ABCB9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCLLLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALFVWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA", "length": 766 }, "evidence": [ { "id": "A0A3Q1LZ87", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ87/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QYJ4-1", "protein_name": "ABC-type oligopeptide transporter ABCB9", "gene_name": "Abcb9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRLWKAVVVTLAFVSMDVGVTTAIYAFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCLLLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMAKLLLFSEVRRPIRDPWFWALFVWTYISLAASFLLWGLLATVRPDAEALEPGNEGFHGEGGAPAEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDSIVIQKSMDQFTTAVVVVCLLAIGSSLAAGIRGGIFTLVFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQSALARASTTAEETISAMKTVRSFANEEEEAEVFLRKLQQVYKLNRKEAAAYMSYVWGSGLTLLVVQVSILYYGGHLVISGQMSSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGRLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLQGGRVLLDGEPIGAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQRHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLEHPLDYTAGHKEPPSNTEHKA", "length": 762 }, "evidence": [ { "id": "A0A3Q1LZ87", "url": "https://omabrowser.org/oma/group/A0A3Q1LZ87/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87" } ], "pmid": "" }, { "name": "ABC-type oligopeptide transporter activity", "id": "GO:0015421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015421", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87" } ], "pmid": "" }, { "name": "ABC-type peptide transporter activity", "id": "GO:0015440", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015440", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87" } ], "pmid": "" }, { "name": "peptide metabolic process", "id": "GO:0006518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006518", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ87", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ87" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": 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The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. 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"MATPPVFLPGESQGWGAWWAAVYGVAQSRTRLKRLSSSSSSDPNSAPVTFLPENRQGRRSPAFCPRAPQGGPGRAGTGIRVSGPRGWGALSAPIRRRPLPEPDGARVGGAPPPRTSGGGGPTRPQQAVVVPRAPGPAHWGFVQPPTATHGLGGCGPRDRAGRRSLWRPRRLQHFPPWPGGAAAAAAAGQSWAELRTPGPPIPARLQAPGPGRQGSCYPCVQRVASWGAPGTPCLGSWGMVLPGLYLGNFIDAKDTDQLGRNKITHIISIHESPQPLLQDITYLRISVADAPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLSWRDVLEAIKATRPIANPNPGFRQQLEEFGWGSSRKLRRQLEERFGESPFRDEEEVRALLPLCKRCRQGSATAAASPAPNSTASEGTLQRLVPRSPREAHRPLPLLARVKQTFSCLPRCLSRKGSK", "length": 467, "header": "tr|A0A3Q1LZA9-1|A0A3Q1LZA9_BOVIN Isoform 1 of Dual specificity protein phosphatase 15 OS=Bos taurus OX=9913 GN=DUSP15 PE=3 SV=2 CANONICAL=A0A3Q1LZA9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZA9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9/entry", "sequence": { "sequence": "MATPPVFLPGESQGWGAWWAAVYGVAQSRTRLKRLSSSSSSDPNSAPVTFLPENRQGRRSPAFCPRAPQGGPGRAGTGIRVSGPRGWGALSAPIRRRPLPEPDGARVGGAPPPRTSGGGGPTRPQQAVVVPRAPGPAHWGFVQPPTATHGLGGCGPRDRAGRRSLWRPRRLQHFPPWPGGAAAAAAAGQSWAELRTPGPPIPARLQAPGPGRQGSCYPCVQRVASWGAPGTPCLGSWGMVLPGLYLGNFIDAKDTDQLGRNKITHIISIHESPQPLLQDITYLRISVADAPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLSWRDVLEAIKATRPIANPNPGFRQQLEEFGWGSSRKLRRQLEERFGESPFRDEEEVRALLPLCKRCRQGSATAAASPAPNSTASEGTLQRLVPRSPREAHRPLPLLARVKQTFSCLPRCLSRKGSK", "length": 467, "header": "tr|A0A3Q1LZA9-1|A0A3Q1LZA9_BOVIN Isoform 1 of Dual specificity protein phosphatase 15 OS=Bos taurus OX=9913 GN=DUSP15 PE=3 SV=2 CANONICAL=A0A3Q1LZA9-1" }, "locus": { "chromosome": "13", "start_pos": 61405161, "end_pos": 61396191, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072892.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072892.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066166.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066166.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 122, "start_aa": "Thr", "end_pos": 122, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr122", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZA9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZA9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZA9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZA9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein serine/threonine phosphatase activity", "id": "GO:0004722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZA9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZA9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1ME76-1", "F1MRH9-1", "A0AAF6DLF7-1", "A0AAA9S9Q3-1", "E1BFE2-1", "E1BL76-1", "G3MXS7-1", "A0A3Q1LUB1-1", "A0AAA9THG9-1", "F1N339-1", "F6RY99-1", "A0AAF6YUC8-1", "A0AAA9RTM1-1", "A0AAA9SMJ6-1", "A0A3Q1LZA9-1", "A7MBD1-1", "A5D7P0-1", "Q58DB6-1", "A0AAA9SEK4-1", "E1BDH9-1", "F1MGK4-1", "E1BIH4-1", "A0A3Q1M6K1-1", "E1BIU8-1", "A7MBJ4-1", "A6H730-1", "A0A3Q1MFX2-1", "A0AAA9U0H6-1", "A2VDT1-1", "E1BPU9-1", "P0C591-1", "P11064-1", "Q0IID7-1", "Q2KJ36-1", "Q2T9S4-1", "E1BPA0-1", "A0AAA9TAZ9-1", "Q5BIP9-1", "A0A3Q1M5K4-1", "F1MM08-1", "E1BJR7-1", "Q17QJ3-1", "Q17QM8-1", "F1MD22-1", "F1MI99-1", "F1MP34-1", "F1MGK5-1", "F1MEZ2-1", "F1MQM7-1", "E1BEZ8-1", "A0A3Q1M0B4-1", "A0AAA9S7W5-1", "A0A3Q1N8V6-1", "A0AAA9TFV5-1", "A0A3Q1MBB1-1", "F1MTZ3-1", "A0AAF6Z8C2-1", "F1MDF1-1", "A0AAA9T5N9-1", "E1BKT4-1", "A0A3Q1MH98-1", "F1N6L3-1", "F1MW70-1", "F1MXF2-1", "A0AAA9TWD1-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] }, { "id": "20629", "name": "", "equation": 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"A0A3Q1N5B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5B2" } ] } ] }, { "uniprot_ac": "A0A3Q1N8V6", "gene_name": "LOC101903026", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", 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"ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] } ] }, { "uniprot_ac": "A0AAA9SWY4", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] } ] }, { "uniprot_ac": "A0AAA9T455", "gene_name": "CDKN3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": 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"https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] } ] }, { "uniprot_ac": "A0AAA9TAZ9", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] } ] }, { "uniprot_ac": "A0AAA9TD32", "gene_name": "CTDP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O 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"A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] } ] }, { "uniprot_ac": "A0AAA9TT76", "gene_name": "PPP3CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] } ] }, { "uniprot_ac": "A0AAA9TV14", "gene_name": "CTDSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] } ] }, { "uniprot_ac": "A0AAA9TWD1", "gene_name": "PTPN20", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YJP2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] } ] }, { "uniprot_ac": "A0AAF6YUC8", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] } ] }, { "uniprot_ac": "A0AAF6Z8C2", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ] }, { "uniprot_ac": "A0ABI0P1A3", "gene_name": "SSH2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] } ] }, { "uniprot_ac": "A2VDT1", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] } ] }, { "uniprot_ac": "A5D7P0", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] } ] }, { "uniprot_ac": "A5PJZ2", "gene_name": "PPM1L", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A6H772", "gene_name": "PPP4C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "A7MBJ4", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] } ] }, { "uniprot_ac": "E1B9Y5", "gene_name": "PPEF2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] } ] }, { "uniprot_ac": "E1BAB2", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] } ] }, { "uniprot_ac": "E1BBD9", "gene_name": "LOC112445820", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] } ] }, { "uniprot_ac": "E1BDH9", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] } ] }, { "uniprot_ac": "E1BEW5", "gene_name": "PPTC7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] } ] }, { "uniprot_ac": "E1BEZ8", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] } ] }, { "uniprot_ac": "E1BF95", "gene_name": "PPM1F", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] } ] }, { "uniprot_ac": "E1BFE2", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] } ] }, { "uniprot_ac": "E1BIE7", "gene_name": "PGAM5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] } ] }, { "uniprot_ac": "E1BIH4", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] } ] }, { "uniprot_ac": "E1BIU8", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] } ] }, { "uniprot_ac": "E1BIZ2", "gene_name": "SSH1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] } ] }, { "uniprot_ac": "E1BJR7", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] } ] }, { "uniprot_ac": "E1BKT4", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] } ] }, { "uniprot_ac": "E1BL76", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] } ] }, { "uniprot_ac": "E1BMD4", "gene_name": "PHLPP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] } ] }, { "uniprot_ac": "E1BPA0", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] } ] }, { "uniprot_ac": "E1BPU9", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] } ] }, { "uniprot_ac": "F1MBQ1", "gene_name": "PPEF1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] } ] }, { "uniprot_ac": "F1MD22", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] } ] }, { "uniprot_ac": "F1MDF1", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MGK4", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] } ] }, { "uniprot_ac": "F1MGK5", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] } ] }, { "uniprot_ac": "F1MI92", "gene_name": "SSH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MRH9", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] } ] }, { "uniprot_ac": "F1MTZ3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] } ] }, { "uniprot_ac": "F1MW60", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1MXF2", "gene_name": "MDP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] } ] }, { "uniprot_ac": "F1N339", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] } ] }, { "uniprot_ac": "F1N580", "gene_name": "PPM1E", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] } ] }, { "uniprot_ac": "F1N6L3", "gene_name": "PTPN22", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] } ] }, { "uniprot_ac": "F1N719", "gene_name": "PPP5C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] } ] }, { "uniprot_ac": "F6RRD7", "gene_name": "RPAP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] } ] }, { "uniprot_ac": "F6RY99", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] } ] }, { "uniprot_ac": "G3MXS7", "gene_name": "PTPRG", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] } ] }, { "uniprot_ac": "G3N3B3", "gene_name": "PPM1N", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] } ] }, { "uniprot_ac": "O62829", "gene_name": "PPM1A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] } ] }, { "uniprot_ac": "O62830", "gene_name": "PPM1B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P11064", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] } ] }, { "uniprot_ac": "P48452", "gene_name": "PPP3CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] } ] }, { "uniprot_ac": "P61287", "gene_name": "PPP1CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] } ] }, { "uniprot_ac": "P67774", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] } ] }, { "uniprot_ac": "P79126", "gene_name": "PPM1G", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q0IIF0", "gene_name": "ILKAP", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] } ] }, { "uniprot_ac": "Q0P594", "gene_name": "PPP2CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] } ] }, { "uniprot_ac": "Q17QI2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q1RMV9", "gene_name": "CTDNEP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMV9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMV9" } ] } ] }, { "uniprot_ac": "Q2KJ36", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] } ] }, { "uniprot_ac": "Q2KJD7", "gene_name": "UBLCP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJD7" } ] } ] }, { "uniprot_ac": "Q2PC20", "gene_name": "PPM1K", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.52", "activity": "O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + H2O = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate.", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.52", "activity": "", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] } ] }, { "uniprot_ac": "Q2T9S4", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "2-phosphoglycolate + H2O = glycolate + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] } ] }, { "uniprot_ac": "Q3SWW9", "gene_name": "PPP1CB", "activity": [ { "ec_number": "3.1.3.53", "activity": "O-phospho-L-threonyl-[myosin light chain] + H2O = L-threonyl-[myosin light chain] + phosphate.", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] }, { "ec_number": "3.1.3.53", "activity": "", "evidence": [ { "id": "Q3SWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWW9" } ] } ] }, { "uniprot_ac": "Q3T0E7", "gene_name": "PPP1CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3T0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3T0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E7" } ] } ] }, { "uniprot_ac": "Q3ZBF9", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": 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"https://bgee.org/?page=gene&gene_id=ENSBTAG00000008124", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07792", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07792", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505987", "url": "https://www.ncbi.nlm.nih.gov/gene/505987", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018484", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018484", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042018", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042018", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FMLMNIG", "url": "https://omabrowser.org/oma/group/FMLMNIG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZC0", "url": "https://www.orthodb.org/?gene=A0A3Q1LZC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MDG3", "url": "https://www.orthodb.org/?gene=A0A3Q1MDG3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NGW6", "url": "https://www.orthodb.org/?gene=A0A3Q1NGW6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NJC9", "url": "https://www.orthodb.org/?gene=A0A3Q1NJC9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10196", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10196", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10196:SF56", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10196:SF56", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00370", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00370", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02782", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02782", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005228369", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228369", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZC0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZC0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDG3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDG3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NGW6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NGW6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJC9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJC9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZAY1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZAY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKLTGEPLYNAVAAPVSPGPSDPAAVVPSGSSVPAAGASSVWLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEDRALFGTIDSWLIWSLTGGASGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFEIPMKILPNVRSSSEIYGLMKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGRKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTNNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSSESGDPSIFCSLPLGFFIVSSVVMLIGARYLSGMP", "length": 581, "header": "tr|A0A3Q1LZC0-1|A0A3Q1LZC0_BOVIN Isoform 1 of glycerol kinase OS=Bos taurus OX=9913 GN=GK PE=3 SV=1 CANONICAL=A0A3Q1LZC0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZC0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZC0/entry", "sequence": { "sequence": "MASAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKLTGEPLYNAVAAPVSPGPSDPAAVVPSGSSVPAAGASSVWLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEDRALFGTIDSWLIWSLTGGASGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFEIPMKILPNVRSSSEIYGLMKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGRKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTNNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSSESGDPSIFCSLPLGFFIVSSVVMLIGARYLSGMP", "length": 581, "header": "tr|A0A3Q1LZC0-1|A0A3Q1LZC0_BOVIN Isoform 1 of glycerol kinase OS=Bos taurus OX=9913 GN=GK PE=3 SV=1 CANONICAL=A0A3Q1LZC0-1" }, "locus": { "chromosome": "X", "start_pos": 112935375, "end_pos": 112861409, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070380.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070380.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062665.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062665.1" } ] } }, { "isoform_ac": "A0A3Q1MDG3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDG3/entry", "sequence": { "sequence": "MASAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKLTGEPLYNAVAAPVSPGPSDPAAVVPSGSSVPAAGASSVWLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEDRALFGTIDSWLIWSLTGGASGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFEIPMKILPNVRSSSEIYGLMKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGRKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTNNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSSESGMP", "length": 552, "header": "tr|A0A3Q1MDG3-1|A0A3Q1LZC0_BOVIN Computationally mapped isoform of glycerol kinase OS=Bos taurus OX=9913 GN=GK PE=3 SV=1 CANONICAL=A0A3Q1LZC0-1" }, "locus": { "chromosome": "X", "start_pos": 112935375, "end_pos": 112861409, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070414.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070414.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066869.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066869.1" } ] } }, { "isoform_ac": "A0A3Q1NGW6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NGW6/entry", "sequence": { "sequence": "MASAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKLTGEPLYNAVVWLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEDRALFGTIDSWLIWSLTGGASGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFEIPMKILPNVRSSSEIYGLMKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGRKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTNNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEVIFFSEGTRKD", "length": 505, "header": "tr|A0A3Q1NGW6-1|A0A3Q1LZC0_BOVIN Computationally mapped isoform of glycerol kinase OS=Bos taurus OX=9913 GN=GK PE=3 SV=2 CANONICAL=A0A3Q1LZC0-1" }, "locus": { "chromosome": "X", "start_pos": 112935375, "end_pos": 112868635, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086560.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086560.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071105.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071105.2" } ] } }, { "isoform_ac": "A0A3Q1NJC9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJC9/entry", "sequence": { "sequence": "MASAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKLTGEPLYNAVVWLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEDRALFGTIDSWLIWSLTGGASGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFEIPMKILPNVRSSSEIYGLMKISHSPKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGRKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTNNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSSESGMP", "length": 530, "header": "tr|A0A3Q1NJC9-1|A0A3Q1LZC0_BOVIN Computationally mapped isoform of glycerol kinase OS=Bos taurus OX=9913 GN=GK PE=3 SV=2 CANONICAL=A0A3Q1LZC0-1" }, "locus": { "chromosome": "X", "start_pos": 112935375, "end_pos": 112861409, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080626.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080626.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072246.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072246.2" } ] } }, { "isoform_ac": "A0AAF6ZAY1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZAY1/entry", "sequence": { "sequence": "MASAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKLTGEPLYNAVVWLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEDRALFGTIDSWLIWSLTGGASGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFEIPMKILPNVRSSSEIYGLMCLGDQSAALVGQMCFQDGQCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTNNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSSESGDPSIFCSLPLGFFIVSSVVMLIGARYLSGQFLFKLDNYMS", "length": 532, "header": "tr|A0AAF6ZAY1-1|A0A3Q1LZC0_BOVIN Computationally mapped isoform of glycerol kinase OS=Bos taurus OX=9913 GN=GK PE=3 SV=1 CANONICAL=A0A3Q1LZC0-1" }, "locus": { "chromosome": "X", "start_pos": 112935375, "end_pos": 112863184, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030932.6", "url": "https://www.ensembl.org/id/ENSBTAT00000030932.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030898.5", "url": "https://www.ensembl.org/id/ENSBTAP00000030898.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5NV46-1", "protein_name": "glycerol kinase", "gene_name": "GK2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAASDRMVLGPLVGSIDQGTSSSRFLVFNAKTAELLSHHQVEIQQKFPKEGWVEQDPKEILRSVHECVERTCEKLQQLNIDITNIKAIGVSNQRETTVVWDKTTGEPLYNAIVWLDLRTQSTVERLLKRIPGNNKSFFKFRTGLPLSTYFSAVKLRWLLDNVEEIRQAVDDGRAMFGTIDSWLIWCLTGGKNGGVHCTDVTNASRTMLFNIHSLDWDPELCQFFDIPMEILPKVRSSSEIYGLMKICPSLKSGALTGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGQKSVFSDHGLLTTIAYKLGRDKPVCYALEGSVAIAGAVVRWLRDNLGIVKTSQEVEKLAAEAGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKNHIAFAALEAVCFQTREILDAMNKDCGIPLSQLQVDGGMTNNKVLMQLQSDILCIPVVKPSMPETTALGAAMAAGAAEGVGIWSLNPGDLTAVTCERFEPQINPEESEYRYARWKKAVMKSMGWETSEAPSNGDTSIFCSLPLGFFIMSSMIMLIGAKYVSGTDK", "length": 561 }, "evidence": [ { "id": "A0A3Q1LZC0", "url": "https://omabrowser.org/oma/group/A0A3Q1LZC0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8C2LYY8-1", "protein_name": "glycerol kinase", "gene_name": "Gk", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKLTGEPLYNAVVWLDLRTQSTVENLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVKKVQKAVEENRALFGTIDSWLIWSLTGGIHGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFEIPMEILPNVRSSSEIYGLMKISHSLKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGHKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSIGWVTTQSPESGDPSIFCSLPLGFFIVSSMVMLIGARYISGIP", "length": 559 }, "evidence": [ { "id": "A0A3Q1LZC0", "url": "https://omabrowser.org/oma/group/A0A3Q1LZC0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P32189-3", "protein_name": "Glycerol kinase", "gene_name": "GK", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILHSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVVWLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPNVRSSSEIYGLMKISHSVKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPESGDPSIFCSLPLGFFIVSSMVMLIGARYISGIP", "length": 559 }, "evidence": [ { "id": "A0A3Q1LZC0", "url": "https://omabrowser.org/oma/group/A0A3Q1LZC0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P32190-1", "protein_name": "Glycerol kinase", "gene_name": "GUT1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MFPSLFRLVVFSKRYIFRSSQRLYTSLKQEQSRMSKIMEDLRSDYVPLIASIDVGTTSSRCILFNRWGQDVSKHQIEYSTSASKGKIGVSGLRRPSTAPARETPNAGDIKTSGKPIFSAEGYAIQETKFLKIEELDLDFHNEPTLKFPKPGWVECHPQKLLVNVVQCLASSLLSLQTINSERVANGLPPYKVICMGIANMRETTILWSRRTGKPIVNYGIVWNDTRTIKIVRDKWQNTSVDRQLQLRQKTGLPLLSTYFSCSKLRWFLDNEPLCTKAYEENDLMFGTVDTWLIYQLTKQKAFVSDVTNASRTGFMNLSTLKYDNELLEFWGIDKNLIHMPEIVSSSQYYGDFGIPDWIMEKLHDSPKTVLRDLVKRNLPIQGCLGDQSASMVGQLAYKPGAAKCTYGTGCFLLYNTGTKKLISQHGALTTLAFWFPHLQEYGGQKPELSKPHFALEGSVAVAGAVVQWLRDNLRLIDKSEDVGPIASTVPDSGGVVFVPAFSGLFAPYWDPDARATIMGMSQFTTASHIARAAVEGVCFQARAILKAMSSDAFGEGSKDRDFLEEISDVTYEKSPLSVLAVDGGMSRSNEVMQIQADILGPCVKVRRSPTAECTALGAAIAANMAFKDVNERPLWKDLHDVKKWVFYNGMEKNEQISPEAHPNLKIFRSESDDAERRKHWKYWEVAVERSKGWLKDIEGEHEQVLENFQ", "length": 709 }, "evidence": [ { "id": "A0A3Q1LZC0", "url": "https://omabrowser.org/oma/group/A0A3Q1LZC0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54VT8-1", "protein_name": "Probable glycerol kinase", "gene_name": "gk", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKPYIGAIDQGTSSTRFILFDKNGDIVLSHQILLTQHHPHPGWVEHDGNEILESVNKCIQVVMKQYYENNFGTKEDIKAIGITNQRETTIVWDKKTSKPLNNAIVWCDTRTKDLVNYFNNKAKKLIDDNNIIDNNSKSTTVVDGAQGECKLESKNYLREKCGLPLSSYFSGLKLKWLFDNCESVREAYGRGDCLMGTIDSWLVWNLTGGKCHITDVTNASRTMLMNLKTLSWDKELCDFLEVPIEILPNIHSSSEIYGHVTMGDDEQQQQQHPLHGIPIAGVLGDQQAAMVGQMCFEKGQAKNTYGTGCFLLYNTGNDIVHSRNGLLTTVCYQFGKDSPPIYALEGGVAVAGSGVRWLIDNMGIAESSQEIEDLAKSVQDTGGMYFVPAFSGLFAPYWRDDARGVMVGLTHHTNRCHIARSVLESTCLQTFEVLDAMQKDSGNKLVELRVDGGMAKNNLLLQIQSDLLGLPVVKPISLETTCFGAAFAAGIATGVWKETMQFKIGGKFTPQLDENHKTQKLKEWKKAISKSLDWIDTKN", "length": 539 }, "evidence": [ { "id": "A0A3Q1LZC0", "url": "https://omabrowser.org/oma/group/A0A3Q1LZC0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q63060-1", "protein_name": "Glycerol kinase", "gene_name": "Gk", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKLTGEPLYNAVVWLDLRTQSTVEKLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVKKVQEAVEENRALFGTIDSWLIWSLTGGINGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFGIPMEILPNVRSSSEIYGLMKISHSLKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGHKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSIGWVTTQSPESGDPSIFCSLPLGFFIVSSMVMLIGARYISGIP", "length": 559 }, "evidence": [ { "id": "A0A3Q1LZC0", "url": "https://omabrowser.org/oma/group/A0A3Q1LZC0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q64516-3", "protein_name": "Glycerol kinase", "gene_name": "Gk", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKVTGEPLYNAVVWLDLRTQSTVENLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVKKVQEAVEENRALFGTIDSWLIWSLTGGIHGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFGIPMEILPNVRSSSEIYGLMKISHSLKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGHKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSIGWVTTQSPESGDPSIFCSLPLGFFIVSSMVMLIGARYISGIP", "length": 559 }, "evidence": [ { "id": "A0A3Q1LZC0", "url": "https://omabrowser.org/oma/group/A0A3Q1LZC0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9M8L4-1", "protein_name": "Glycerol kinase", "gene_name": "GLPK", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAKENGFIGSIDQGTTSTRFIIYDHDARPVASHQVEFTQFYPEAGWVEHDPMEILESVKVCIAKALDKATADGHNVDGGLKAIGLTDQRETTVVWSKSTGLPLHKAIVWMDARTSSICRRLEKELSGGRSHFVESCGLPISTYFSAMKLLWLMENVDDVKDAIKKGDAIFGTIDTWLIWNMTGGINGGLHVTDVTNASRTMLMNLKTLSWDQDTLKTLGIPAEILPKIVSNSEVIGEICKGWPIPGIKIAGCLGDQHAAMLGQACRKGEAKSTYGTGAFILLNTGEVPIKSGHGLLTTLAYKLGPQAQTNYALEGSIAIAGAAVQWLRDSLGIIKSASEIEDLAAMVDSTGGVYFVPAFNGLFAPWWREDARGVCIGITRFTNKSHIARAVLESMCFQVKDVLDSMNKDAGEKGSLNNGKGEFLLRVDGGATANNLLMQIQADLMGSPVVRPVDIETTALGAAYAAGLAVGFWKEADIFESGEKAKNSKVFRPAMEEGIRKKKVASWCKAVERTFDLADLSI", "length": 522 }, "evidence": [ { "id": "A0A3Q1LZC0", "url": "https://omabrowser.org/oma/group/A0A3Q1LZC0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9W0U0-1", "protein_name": "glycerol kinase", "gene_name": "Gk1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDSPTTETTPPPPTLSGPFVGAIDEGTTSARFIIFRAGTDEIVCFHQIEVESIFQKEGWCEQDPMAIVNTVNECITGACKKLVAVGGKVEEIITIGITNQRESTVVWDRNSGQPLVNAIIWLDNRTTSTVEELLETIPNNARNINYLRPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTAMFGTIDTWLMYNLTGGKDCGVHKTDVTNASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSEFYGSIAQGVLQGIGITSVLGDQQAALVGQQCLAKGQAKATYGTGCFLLYNTGPSIVHSTHGLLTTVGYQLGRKAVPFYALEGSVSIAGAAFNWLRDNMNLIQNSGQIETMASTVDNSLDVYFVPAFNGLYAPYWNQDARGVICGLSEETTSEHIVRATLEAVCFQVRDILDSMHKDCKIPLAKLMVDGGMTVNNLFLQLQSDLVGIQVLRAKIAETTALGAAMAAYKAVENRYQMEAPLSKSGPREAIKPSISATDRNLRYQKWKMAIDRSLNWETSTLPQGEREAFDGA", "length": 538 }, "evidence": [ { "id": "A0A3Q1LZC0", "url": "https://omabrowser.org/oma/group/A0A3Q1LZC0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "glycerol kinase activity", "id": "GO:0004370", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004370", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZC0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZC0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZC0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZC0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "glycerol catabolic process", "id": "GO:0019563", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019563", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZC0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZC0" } ], "pmid": "" }, { "name": "triglyceride biosynthetic process", "id": "GO:0019432", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019432", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZC0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZC0" } ], "pmid": "" }, { "name": "glycerol-3-phosphate metabolic process", "id": "GO:0006072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006072", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZC0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZC0" } ], "pmid": "" }, { "name": "glycerol metabolic process", "id": "GO:0006071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006071", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZC0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZC0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZC0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZC0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZC0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZC0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LZC0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 581, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LZC0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LZC0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LZC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZC0" }, { "id": "PF02782", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02782" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Carbohydrate kinase FGGY C-terminal", "eco_id": "ECO_0000259", "start_pos": 304, "end_pos": 494, "start_aa": "Lys", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LZC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZC0" }, { "id": "PF00370", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00370" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Carbohydrate kinase FGGY N-terminal", "eco_id": "ECO_0000259", "start_pos": 13, "end_pos": 112, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.30", "ec_name": "glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+).", "evidence": [ { "id": "2.7.1.30", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.30" }, { "id": "2.7.1.30", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.30" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 229, "end_pos": 231 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LZD9-1", "uniprot_ac": "A0A3Q1LZD9", "uniprot_id": "A0A3Q1LZD9_BOVIN", "mass": { "chemical_mass": 36005.0, "monoisotopic_mass": 36005.0 }, "refseq": { "ac": "XP_005209235", "name": "heterogeneous nuclear ribonucleoprotein A/B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209235" }, "gene_names": [ { "name": "HNRNPAB", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9" } ] }, { "name": "HNRNPAB", "type": "synonym", "evidence": [ { "id": "XP_005209235", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209235" } ] }, { "name": "HNRPAB", "type": "synonym", "evidence": [ { "id": "XP_005209235", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209235" } ] } ], "protein_names": [ { "name": "Heterogeneous nuclear ribonucleoprotein A/B", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9/entry#names_and_taxonomy" } ] }, { "name": "heterogeneous nuclear ribonucleoprotein A/B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005209235", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209235" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HNRNPAB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9", "locus": { "chromosome": "7", "start_pos": 39287181, "end_pos": 39280575, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013627", "url": "https://www.ensembl.org/id/ENSBTAG00000013627" } ] } } ], "crossref": [ { "id": "A0A3Q1LZD9", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LZD9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013627", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013627", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12584", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12584", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12757", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12757", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513410", "url": "https://www.ncbi.nlm.nih.gov/gene/513410", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012956", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012956", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NQGYNYW", "url": "https://omabrowser.org/oma/group/NQGYNYW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZD9", "url": "https://www.orthodb.org/?gene=A0A3Q1LZD9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48033", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48033", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48033:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48033:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08143", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08143", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005209235", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209235", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZD9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEAGEEQPMETTGATENGHEAAPEGESPAGTGTGVAAGAGGGSAAPQAGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGFILFKDATSVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLNPEATEEKIREYFGEFGEIEAIELPMDPKSNKRRGFVFITFKEEEPVKKVLEKKFHTISGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGGGSGGQSQSWNQGYGSYWNQGYGYQQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQRRGGHQNNYKPY", "length": 332, "header": "tr|A0A3Q1LZD9-1|A0A3Q1LZD9_BOVIN Isoform 1 of Heterogeneous nuclear ribonucleoprotein A/B OS=Bos taurus OX=9913 GN=HNRNPAB PE=1 SV=1 CANONICAL=A0A3Q1LZD9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZD9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9/entry", "sequence": { "sequence": "MSEAGEEQPMETTGATENGHEAAPEGESPAGTGTGVAAGAGGGSAAPQAGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGFILFKDATSVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLNPEATEEKIREYFGEFGEIEAIELPMDPKSNKRRGFVFITFKEEEPVKKVLEKKFHTISGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGGGSGGQSQSWNQGYGSYWNQGYGYQQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQRRGGHQNNYKPY", "length": 332, "header": "tr|A0A3Q1LZD9-1|A0A3Q1LZD9_BOVIN Isoform 1 of Heterogeneous nuclear ribonucleoprotein A/B OS=Bos taurus OX=9913 GN=HNRNPAB PE=1 SV=1 CANONICAL=A0A3Q1LZD9-1" }, "locus": { "chromosome": "7", "start_pos": 39286177, "end_pos": 39280895, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082673.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082673.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062686.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062686.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QWN8-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein A/B", "gene_name": "HNRNPAB", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSEAGEEQPMETTGATENGHEAAPEGESPAGTGTGAAAGSGGGTAAPPAGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGFILFKDAASVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLNPEATEEKIREYFGEFGEIEAIELPMDPKSNKRRGFVFITFKEEEPVKKVLEKKFHTISGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGQSQSWNQGYGSYWNQGYGYQQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQRRGGHQNNYKPY", "length": 327 }, "evidence": [ { "id": "A0A3Q1LZD9", "url": "https://omabrowser.org/oma/group/A0A3Q1LZD9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YRG0-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein A/B", "gene_name": "HNRNPAB", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSEAEQQLAAAAGATQNGHEAAESSGEQQQADTGGAPAASAGAATAAAATAGTAAAAGAGPAAGTAGVAASQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVTDCTIKMDPNTGRSRGFGFILFKEPGSVEKVLEQKEHRLDGRLIDPKKAMAMKKDPVKKIFVGGLNPEATEEKIREYFGEFGEIEAIELPMDPKTNKRRGFVFITFKEEDPVKKVLEKKFHNVSGSKCEIKVAQPKEVYQQQQFSSGGGRGSYGGRGRGGRGGAQSQNWNQGYGNYWNQGYGNQGYGYQQGYGGYGGYDYSGYGYYGYGPGYDYSQGSANYGKTPRRGGHQNNYKPY", "length": 353 }, "evidence": [ { "id": "A0A3Q1LZD9", "url": "https://omabrowser.org/oma/group/A0A3Q1LZD9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q99729-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein A/B", "gene_name": "HNRNPAB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEAGEEQPMETTGATENGHEAVPEASRGRGWTGAAAGAGGATAAPPSGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGFILFKDAASVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLNPESPTEEKIREYFGEFGEIEAIELPMDPKLNKRRGFVFITFKEEEPVKKVLEKKFHTVSGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGGGGGGQSQSWNQGYGNYWNQGYGYQQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQRRGGHQNNYKPY", "length": 332 }, "evidence": [ { "id": "A0A3Q1LZD9", "url": "https://omabrowser.org/oma/group/A0A3Q1LZD9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mRNA modification", "id": "GO:0016556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016556", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9" } ], "pmid": "" }, { "name": "negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "id": "GO:2000623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000623", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZD9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LZD9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 332, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LZD9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LZD9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LZD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZD9" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 70, "end_pos": 155, "start_aa": "Gly", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 61, "end_pos": 63 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LZF1-1", "uniprot_ac": "A0A3Q1LZF1", "uniprot_id": "A0A3Q1LZF1_BOVIN", "mass": { "chemical_mass": 66538.0, "monoisotopic_mass": 66538.0 }, "refseq": {}, "gene_names": [ { "name": "AIFM3", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1" } ] } ], "protein_names": [ { "name": "Apoptosis-inducing factor 3", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1/entry#names_and_taxonomy" } ] }, { "name": "Apoptosis-inducing factor-like protein", "type": "synonym", "evidence": [ { "id": "A0A3Q1LZF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1#function" }, { "database": "UniProtKB", "id": "ARBA00058975", "url": "https://www.uniprot.org/uniprotkb/ARBA00058975#function" }, { "database": "UniProtKB", "id": "A0A3Q1M0Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Q2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AIFM3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1", "locus": { "chromosome": "17", "start_pos": 72326197, "end_pos": 72314486, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038132", "url": "https://www.ensembl.org/id/ENSBTAG00000038132" } ] } } ], "crossref": [ { "id": "A0A3Q1LZF1", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LZF1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038132", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038132", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03478", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03478", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526295", "url": "https://www.ncbi.nlm.nih.gov/gene/526295", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR016156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017941", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017941", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036188", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036188", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036922", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036922", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050446", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050446", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526295", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526295", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PRCTHYG", "url": "https://omabrowser.org/oma/group/PRCTHYG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZF1", "url": "https://www.orthodb.org/?gene=A0A3Q1LZF1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0Q2", "url": "https://www.orthodb.org/?gene=A0A3Q1M0Q2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43557", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43557", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43557:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43557:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00355", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00355", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07992", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07992", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14759", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14759", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LZF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZF1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0Q2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Q2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Q2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGCFSKPKPVELKIEVVLPEKDRGKEELSTGSRGSPRAYQGNGAARHFHADERLPTAHPYPGAQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGELHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNVSTGDLEDFPGLDSLHKFQVKIEKEKVYIRASKQALQLQRRTKVMATCISPSAGYSGSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSKSLDAQPEQLALRPKEFFRAHGIEVLTEAQVVTVDVRNKKAVFKDGFKLEYSKLLLAPGSSPKTLSCKGKDVENVFTIRTPEDANRVVRLARGRNAVVVGAGFLGMEVAAYLTEKAHSVSVVEVEETPFRRFLGERVGHTLMKMFENNRVKFYMQTEVSELRAQEGKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGISLDSRGFIPVNKMMQTNIPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEISTVPFLWTAMFGKSLRYAGYGEGFDDVIIQGDLDELKFVAFYTKGDEVISVASMNYDPIVSKVAEVLASGRTIRKREVELFVLHSKTGDMSWLTGKGS", "length": 605, "header": "tr|A0A3Q1LZF1-1|A0A3Q1LZF1_BOVIN Isoform 1 of Apoptosis-inducing factor 3 OS=Bos taurus OX=9913 GN=AIFM3 PE=3 SV=2 CANONICAL=A0A3Q1LZF1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZF1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1/entry", "sequence": { "sequence": "MGGCFSKPKPVELKIEVVLPEKDRGKEELSTGSRGSPRAYQGNGAARHFHADERLPTAHPYPGAQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGELHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNVSTGDLEDFPGLDSLHKFQVKIEKEKVYIRASKQALQLQRRTKVMATCISPSAGYSGSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSKSLDAQPEQLALRPKEFFRAHGIEVLTEAQVVTVDVRNKKAVFKDGFKLEYSKLLLAPGSSPKTLSCKGKDVENVFTIRTPEDANRVVRLARGRNAVVVGAGFLGMEVAAYLTEKAHSVSVVEVEETPFRRFLGERVGHTLMKMFENNRVKFYMQTEVSELRAQEGKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGISLDSRGFIPVNKMMQTNIPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEISTVPFLWTAMFGKSLRYAGYGEGFDDVIIQGDLDELKFVAFYTKGDEVISVASMNYDPIVSKVAEVLASGRTIRKREVELFVLHSKTGDMSWLTGKGS", "length": 605, "header": "tr|A0A3Q1LZF1-1|A0A3Q1LZF1_BOVIN Isoform 1 of Apoptosis-inducing factor 3 OS=Bos taurus OX=9913 GN=AIFM3 PE=3 SV=2 CANONICAL=A0A3Q1LZF1-1" }, "locus": { "chromosome": "17", "start_pos": 72325843, "end_pos": 72315390, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087247.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087247.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062702.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062702.2" } ] } }, { "isoform_ac": "A0A3Q1M0Q2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Q2/entry", "sequence": { "sequence": "MGGCFSKPKPVELKIEVVLPEKDRGKEELSTGSRGSPRAYQGNGAARHFHADERLPTAHPYPGAQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGELHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNVSTGDLEDFPGLDSLHKFQVKIEKEKVYIRASKQALQLQRRTKVMATCISPSAGYSGSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSKSLDAQPEQLALRPKEFFRAHGIEVLTEAQVVTVDVRNKKAVFKDGFKLEYSKLLLAPGSSPKTLSCKGKDVENVFTIRTPEDANRVVRLARGRNAVVVGAGFLGMEVAAYLTEKAHSVSVVEVEETPFRRFLGERVGHTLMKMFENNRVKFYMQTEVSELRAQEGKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGISLDSRGFIPVNKMMQTNIPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEISTVPFLWTAMFGKSLRYAGYGEGFDDVIIQGDLDELKFVAFYTKGDEVISVASMNYDPIVSKVAEVLASGRTIRKREVETGDMSWLTGKGS", "length": 598, "header": "tr|A0A3Q1M0Q2-1|A0A3Q1LZF1_BOVIN Computationally mapped isoform of Apoptosis-inducing factor 3 OS=Bos taurus OX=9913 GN=AIFM3 PE=3 SV=2 CANONICAL=A0A3Q1LZF1-1" }, "locus": { "chromosome": "17", "start_pos": 72325843, "end_pos": 72315390, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073095.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073095.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061580.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061580.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526295", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526295", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UXM0-1", "protein_name": "Apoptosis-inducing factor 3", "gene_name": "AIFM3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGGCFSKPKPVELKIEVVLPEKDRKEELSASGKGSPRAYQGNGTARHFHAEERLPAPHPYPGAQDFMEAAVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYVRASKQALQLQRRTKVMATCISPSAGHSGSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSKSLDTQPEQLALRPKEFFRAHGIEVLTEAQVVTVDVRNKKAVFKDGFKLEYSKLLLAPGSSPKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNAVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRLLGERVGRALMKMFENNRVKFYMQTEVLELRAQEGKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEISTVPYLWTAMFGKSLRYAGYGEGFDDVVIQGDLHELKFVAFYTKGDEVISVASMNYDPIVSKVAEVLASGRSIRKREVELFLLHSKTGDMSWLTGKGS", "length": 604 }, "evidence": [ { "id": "A0A3Q1LZF1", "url": "https://omabrowser.org/oma/group/A0A3Q1LZF1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2N0N1-1", "protein_name": "Apoptosis-inducing factor 3", "gene_name": "Aifm3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHAEERLPTPQPYPSPQDCVEATVCHVKDLENGQMREVELGWGKVLLLKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVTVRASKQALQLQRRTKVMAKCISPSAGHSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRAKLSKSLDAQPEQLALRPKEFFRAYGIEMLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAPGSSPKTLNCKGKDVENVFTIRTPEDANHVLRLARGRNAVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVLELRAQEGKLQEVVLKSSKVLRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNIPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEINTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRTIRKREVETGDMSWLTGRGS", "length": 598 }, "evidence": [ { "id": "A0A3Q1LZF1", "url": "https://omabrowser.org/oma/group/A0A3Q1LZF1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8M2BC75-1", "protein_name": "Apoptosis-inducing factor 3 isoform X1", "gene_name": "aifm3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGGCLSKPKPVEVKVELTLLDKEKEVDLMSPNGKASPFSECRPNGSLGHCSDEDSMTLRPQRKNRDYIEASVCHIKDLENGQMREVDLGAGRALLIKEHGEFFAMGHKCPHYGAPLVKGVLSKGHVRCPWHGACFNIATGDIEDFPGLDSLPTFQVRVEKEKVIIRANKQALQTQRRSKVMSKCSAVINSSTGFSHVLIIGSGPAGLVCAETLRQEGFTDRIVICTTDKHLPYDRPKLSKSLESTAEQLQLRSSDFFQMHDIEVLLEKEVVSVDVKTHTVTFRDGFKMEYRKLFIATGSRPKPLSYKGKDVGNVFHLRTPEDANSIVTLASSKNAVIIGTSFIGMEVAAALTDKAHSVSVIGIEAVPFRKALGEKVGKALMKLFEANRVKFYMLNEVWEMRGHNGQLKEVVLKSGKVLRADVCVIGIGSSPATAFLKQSGVHIDSKGFIPVNKTMQTNIDGVFAGGDVVTFPLALRSNKKVNIPHWQMAHVHGRLAALGIMGKASDIKTVPYFWTAMFGKSIRYAGYGDGFDDVVIQGDLDELKFVAFYTKSEEVVAVASMNYDPIVSRVAEVFGSGKTIRKRDVETGDMSWLIVKGSQ", "length": 599 }, "evidence": [ { "id": "A0A3Q1LZF1", "url": "https://omabrowser.org/oma/group/A0A3Q1LZF1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZF03-1", "protein_name": "Apoptosis-inducing factor 3", "gene_name": "Aifm3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRGYQGNGTARHFHAEERLPTPQPYPSPQDCVEATVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNIGTGDLEDFPGLDSLHKFQVKIEKEKVTVRASKQALQLQRRTKVMAKCISPSAGHSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRAKLSKSLDAQPEQLALRPKEFFRAYGIEMLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAPGSSPKTLTCKGKDIENVFTIRTPEDANRVLRLARGRNAVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRAQEGKLQEVVLKSSKVLRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNIPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEINTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFMLHSKTGDMSWLTGKGS", "length": 604 }, "evidence": [ { "id": "A0A3Q1LZF1", "url": "https://omabrowser.org/oma/group/A0A3Q1LZF1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3TY86-1", "protein_name": "Apoptosis-inducing factor 3", "gene_name": "Aifm3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRGYQGNGTARHFHAEERLPTPQPYPSPQDCVEATVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVTIRASKQALQLQRRTKVMAKCISPSAGHSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRAKLSKSLDAQPEQLALRPKEFFRAYGIEMLTEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAPGSSPKTLTCKGKDVENVFTIRTPEDANRVLRLARGRNAVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRAQEGKLQEVVLKSSKVLRADVCVLGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEINTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKSDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFMLHSKTGDMSWLTGKGS", "length": 605 }, "evidence": [ { "id": "A0A3Q1LZF1", "url": "https://omabrowser.org/oma/group/A0A3Q1LZF1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96NN9-1", "protein_name": "Apoptosis-inducing factor 3", "gene_name": "AIFM3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEERLSTPHPYPSPQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYVRASKQALQLQRRTKVMAKCISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSKSLDTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSSPKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFVLHSKTGDMSWLTGKGS", "length": 605 }, "evidence": [ { "id": "A0A3Q1LZF1", "url": "https://omabrowser.org/oma/group/A0A3Q1LZF1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9LFA3-1", "protein_name": "Monodehydroascorbate reductase 1, peroxisomal", "gene_name": "MDAR1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAEKSFKYIILGGGVSAGYAAKEFANQGVQPGELAVISKEAVAPYERPALSKGYLFPEGAARLPGFHCCVGSGGEKLLPESYKQKGIELILSTEIVKADLSAKSLVSATGDVFKYQTLIIATGSTVLRLTDFGVKGADSKNILYLREIDDADKLVEAIKAKKGGKAVVVGGGYIGLELSAVLRINNLDVTMVFPEPWCMPRLFTADIAAFYETYYTNKGVKIIKGTVASGFTAQPNGEVKEVQLKDGRTLEADIVIVGVGAKPLTSLFKGQVEEDKGGIKTDAFFKTSVPDVYAVGDVATFPLKMYGDVRRVEHVDHSRKSAEQAVKAIKAAEGGAAVEEYDYLPFFYSRSFDLSWQFYGDNVGDSVLFGDSNPSNPKPRFGAYWVQGGKVVGAFMEGGSGDENKALAKVAKARPSAESLDELVKQGISFAAKI", "length": 434 }, "evidence": [ { "id": "A0A3Q1LZF1", "url": "https://omabrowser.org/oma/group/A0A3Q1LZF1/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1" } ], "pmid": "" }, { "name": "2 iron, 2 sulfur cluster binding", "id": "GO:0051537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051537", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on NAD(P)H", "id": "GO:0016651", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016651", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "execution phase of apoptosis", "id": "GO:0097194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097194", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LZF1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 605, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LZF1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LZF1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LZF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF1" }, { "id": "PS51296", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51296" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rieske", "eco_id": "ECO_0000259", "start_pos": 70, "end_pos": 165, "start_aa": "Ala", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 136, "end_pos": 138 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LZM4-1", "uniprot_ac": "A0A3Q1LZM4", "uniprot_id": "A0A3Q1LZM4_BOVIN", "mass": { "chemical_mass": 21536.0, "monoisotopic_mass": 21536.0 }, "refseq": { "ac": "NP_001422206", "name": "NF-kappa-B inhibitor-interacting Ras-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422206" }, "gene_names": [ { "name": "NKIRAS1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZM4", "database": "UniProtKB", "url": 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"MSQHCRSWVPILRKQNHAFEKTHTTVSTAALFTTAETQKQPKCSSTAISEEKMGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGLGDCETLEDVYMASVETDRGVKEQLHLYDTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGNKIDLSEQRQVDAEVAQQWARSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLPGRKNKGNSSSEN", "length": 244, "header": "tr|A0A3Q1M2R8-1|A0A3Q1LZM4_BOVIN Computationally mapped isoform of NFKB inhibitor interacting Ras like 1 OS=Bos taurus OX=9913 GN=NKIRAS1 PE=3 SV=1 CANONICAL=A0A3Q1LZM4-1" }, "locus": { "chromosome": "27", "start_pos": 42075080, "end_pos": 42061621, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078457.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078457.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062411.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062411.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1810476", "name": "", "url": 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"http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11987:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00777", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00777", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-4085001", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085001", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975577", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975577", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005224168", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224168", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZS9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZS9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRNCKMARVASVLGLIMLSVALLILSLISYVSLKKESIFTTPKYANPGAPRMYMLHAGFRSQFALKLLDSSLVPFPHSVTHELQARPKWTFNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIVNKRYNICAVVGNSGILTGSRCGPQIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKLQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAVCEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTLSHCA", "length": 379, "header": "tr|A0A3Q1LZS9-1|A0A3Q1LZS9_BOVIN Isoform 1 of ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 OS=Bos taurus OX=9913 GN=ST8SIA3 PE=3 SV=1 CANONICAL=A0A3Q1LZS9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZS9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZS9/entry", "sequence": { "sequence": "MRNCKMARVASVLGLIMLSVALLILSLISYVSLKKESIFTTPKYANPGAPRMYMLHAGFRSQFALKLLDSSLVPFPHSVTHELQARPKWTFNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIVNKRYNICAVVGNSGILTGSRCGPQIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKLQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAVCEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTLSHCA", "length": 379, "header": "tr|A0A3Q1LZS9-1|A0A3Q1LZS9_BOVIN Isoform 1 of ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 OS=Bos taurus OX=9913 GN=ST8SIA3 PE=3 SV=1 CANONICAL=A0A3Q1LZS9-1" }, "locus": { "chromosome": "24", "start_pos": 56622813, "end_pos": 56614891, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068182.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068182.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061230.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061230.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-4085001", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085001", "resource": "Reactome", "description": "Sialic acid metabolism" }, { "id": "R-BTA-975577", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975577", "resource": "Reactome", "description": "N-Glycan antennae elongation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y122-1", "protein_name": "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3", "gene_name": "ST8SIA3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRSCKMVRVASVLGLVMLSIALLILSLISYVSLKKDNIFGAPRAAGPGGPRMYMFHAGFRSQFALKFLDPSFVPITNSLGQELQEKPSKWVFNRTAFAQQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPILNKHYNVCAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQKDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLAKLTLSRCA", "length": 380 }, "evidence": [ { "id": "A0A3Q1LZS9", "url": "https://omabrowser.org/oma/group/A0A3Q1LZS9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3V8D0-1", "protein_name": "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3", "gene_name": "St8sia3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRNCKMARVASILGLVMLSVALLILSLISYVSLKKENIFTTPKYASPGAPRMYMFHAGFRSQFALKFLDPSFVPITNSLTHELQEKPSKWTFNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLIHYDYSSHKYVFSISNNFRSLLPDVSPILNKRYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFHKDVGKKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTLSHCA", "length": 380 }, "evidence": [ { "id": "A0A3Q1LZS9", "url": "https://omabrowser.org/oma/group/A0A3Q1LZS9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O43173-1", "protein_name": "Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3", "gene_name": "ST8SIA3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRNCKMARVASVLGLVMLSVALLILSLISYVSLKKENIFTTPKYASPGAPRMYMFHAGFRSQFALKFLDPSFVPITNSLTQELQEKPSKWKFNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTLSHCA", "length": 380 }, "evidence": [ { "id": "A0A3Q1LZS9", "url": "https://omabrowser.org/oma/group/A0A3Q1LZS9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q64689-1", "protein_name": "Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3", "gene_name": "St8sia3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRNCKMARVASVLGLVMLSVALLILSLISYVSLKKENIFTTPKYASPGAPRMYMFHAGFRSQFALKFLDQSFVPITNSLTHELQEKPSKWTFNRTAFLHQRQEILQHVDVIKNFSLTKSSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKRYNVCAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFHKDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTLSHCA", "length": 380 }, "evidence": [ { "id": "A0A3Q1LZS9", "url": "https://omabrowser.org/oma/group/A0A3Q1LZS9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity", "id": "GO:0003828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003828", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZS9" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZS9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZS9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "oligosaccharide metabolic process", "id": "GO:0009311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009311", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZS9" } ], "pmid": "" }, { "name": "N-glycan processing", "id": "GO:0006491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006491", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZS9" } ], "pmid": "" }, { "name": "sialylation", "id": "GO:0097503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097503", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZS9" } ], "pmid": "" }, { "name": "ganglioside biosynthetic process", "id": "GO:0001574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001574", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZS9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZS9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1LZS9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 379, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1LZS9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LZS9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G01044XE", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G03325PY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G04483QG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G09480OP", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G09859LE", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G14533ZS", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G25019NQ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G26740EB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G27817KG", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G29326OK", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G40463TJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G54413TX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G62680DG", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G65867LM", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G70224BV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G75311QH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G85002XD", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G87293AR", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G90721SF", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G93910CU", "type": "O-linked", "subtype": "Core 1" }, { "glytoucan_ac": "G99527BL", "type": "O-linked", "subtype": "Core 1" } ], 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LZT3-1", "uniprot_ac": "A0A3Q1LZT3", "uniprot_id": "A0A3Q1LZT3_BOVIN", "mass": { "chemical_mass": 127342.0, "monoisotopic_mass": 127342.0 }, "refseq": {}, "gene_names": [ { "name": "LOC101904063", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT3" } ] } ], "protein_names": [ { "name": "VWFA domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZT3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC101904063", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT3", "locus": {} } ], "crossref": [ { "id": "A0A3Q1LZT3", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LZT3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054461", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054461", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01469", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01469", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013517", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013517", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013649", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013649", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018184", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032695", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032695", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048285", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048285", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048633", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048633", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EITGDRW", "url": "https://omabrowser.org/oma/group/EITGDRW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23220", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23220", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23220:SF118", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23220:SF118", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00357", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00357", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01839", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01839", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08441", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08441", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20805", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20805", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202733", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000178", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LZT3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZT3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P146", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P146", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P146-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P146-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTRTRVFLFLLMAPVSSLCFNLDTEQPTTFRVDSPGFGHSVVQYAQWLVVGAPREVKAANQTGGLYSCDYGTGKCEAIPLQVPPEAVNMSLGLSMAATTNPFQLLACGPTVHHACRENMHLTGTCFLLASPFRQVKRIPAALQECPRQDQDIAFLIDGSGSIFSSDFNKMLNFVKAVMSQFQRPNSQFSLVQFSSTFKVHFAFKDFATSSDPLSLLNSVQQLQGWTFTASAIRFVTDLLSAANGARKDASKILIVITDGEKTENLGYKDVIPRAEAAGIIRYAIGVGSAFRYKKSLKELIDIASTPSEEHVFQVENFDALRDIQKQLKEKIFAIEGTQTISSSSFELEMSQEGFSAVFMPDGPVLGAVGSFSWSGGAFLYPPNKNPTFINMSQEHVDMRDSYLGYSTELALWRGAQSLILGAPRHQHTGKVVLFTQVSRQWRPQAEVTGTQIGSYFGASLCSVDVNGDSSSDLILIGAPHFYEQTQGGQVSVCPFPRGRAKWQCDAVLRGEPGHPWGRFGAALTALGDVNGDRLADVAIGAPGEQENQGAVYLFHGTSELGISPSHSQRVTGAQLSPSLQYFGQSLSGGQDLTQDGLADVAVGAQGHALLLRTRPVLRMWANIHITPAEIARSVYECQQLVTFPHDLGKAIVCLQVSQSSKNQLVNLQSIVTFDLTLDPGRLSSRAIFQETGTRNLTRVRELGLKQHCEAVRLLLPDCVEDSVTPIILRLNFSLVGKPISSLRNLQPMLAVDAQRYFTTSLPFEKNCGADHVCQDDLSISFGVSDLKTLIVGSNLELNLKVRVWNDGEDSYGTAVTFFYPPGLSYRRVTGGQSHLQSRSLRLTCDSAPAGTQGTRSTRCSVNHLIFREGAQVTFTVTFHVSPTATLGDKLLLAANVSSENNSPKTSKTAFQLELPVKYAVYTVISSHEQSTKYLNFSASQEEGSREAQHRYQARVNNLGQRELPVSIDISVPMELNQVPVWKDIEVLNPQNPSIQCSSERTAPTESDFLTHFKKKPVLDCSIAVCLRFRCDIPSFGIQEELDFILKGNLSFRWVSQTQQKKVLVVSVAEITFNRLVYSQLPGQETFLRAQTELVLEKYEVYNPIPLIVGSSLGGLLLLALITALLYKVGFFKRQYKEMMEGANQQTVPENETGNPQAAQ", "length": 1159, "header": "tr|A0A3Q1LZT3-1|A0A3Q1LZT3_BOVIN Isoform 1 of VWFA domain-containing protein OS=Bos taurus OX=9913 GN=LOC101904063 PE=3 SV=2 CANONICAL=A0A3Q1LZT3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZT3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT3/entry", "sequence": { "sequence": "MTRTRVFLFLLMAPVSSLCFNLDTEQPTTFRVDSPGFGHSVVQYAQWLVVGAPREVKAANQTGGLYSCDYGTGKCEAIPLQVPPEAVNMSLGLSMAATTNPFQLLACGPTVHHACRENMHLTGTCFLLASPFRQVKRIPAALQECPRQDQDIAFLIDGSGSIFSSDFNKMLNFVKAVMSQFQRPNSQFSLVQFSSTFKVHFAFKDFATSSDPLSLLNSVQQLQGWTFTASAIRFVTDLLSAANGARKDASKILIVITDGEKTENLGYKDVIPRAEAAGIIRYAIGVGSAFRYKKSLKELIDIASTPSEEHVFQVENFDALRDIQKQLKEKIFAIEGTQTISSSSFELEMSQEGFSAVFMPDGPVLGAVGSFSWSGGAFLYPPNKNPTFINMSQEHVDMRDSYLGYSTELALWRGAQSLILGAPRHQHTGKVVLFTQVSRQWRPQAEVTGTQIGSYFGASLCSVDVNGDSSSDLILIGAPHFYEQTQGGQVSVCPFPRGRAKWQCDAVLRGEPGHPWGRFGAALTALGDVNGDRLADVAIGAPGEQENQGAVYLFHGTSELGISPSHSQRVTGAQLSPSLQYFGQSLSGGQDLTQDGLADVAVGAQGHALLLRTRPVLRMWANIHITPAEIARSVYECQQLVTFPHDLGKAIVCLQVSQSSKNQLVNLQSIVTFDLTLDPGRLSSRAIFQETGTRNLTRVRELGLKQHCEAVRLLLPDCVEDSVTPIILRLNFSLVGKPISSLRNLQPMLAVDAQRYFTTSLPFEKNCGADHVCQDDLSISFGVSDLKTLIVGSNLELNLKVRVWNDGEDSYGTAVTFFYPPGLSYRRVTGGQSHLQSRSLRLTCDSAPAGTQGTRSTRCSVNHLIFREGAQVTFTVTFHVSPTATLGDKLLLAANVSSENNSPKTSKTAFQLELPVKYAVYTVISSHEQSTKYLNFSASQEEGSREAQHRYQARVNNLGQRELPVSIDISVPMELNQVPVWKDIEVLNPQNPSIQCSSERTAPTESDFLTHFKKKPVLDCSIAVCLRFRCDIPSFGIQEELDFILKGNLSFRWVSQTQQKKVLVVSVAEITFNRLVYSQLPGQETFLRAQTELVLEKYEVYNPIPLIVGSSLGGLLLLALITALLYKVGFFKRQYKEMMEGANQQTVPENETGNPQAAQ", "length": 1159, "header": "tr|A0A3Q1LZT3-1|A0A3Q1LZT3_BOVIN Isoform 1 of VWFA domain-containing protein OS=Bos taurus OX=9913 GN=LOC101904063 PE=3 SV=2 CANONICAL=A0A3Q1LZT3-1" }, "locus": { "chromosome": "25", "start_pos": 27417796, "end_pos": 27398592, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069265.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069265.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061235.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061235.2" } ] } }, { "isoform_ac": "A0ABI0P146-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P146/entry", "sequence": { "sequence": "MTRTRVFLFLLMAPVSSLCFNLDTEQPTTFRVDSPGFGHSVVQYAQWLVVGAPREVKAANQTGGLYSCDYGTGKCEAIPLQVPPEAVNMSLGLSMAATTNPFQLLACGPTVHHACRENMHLTGTCFLLASPFRQVKRIPAALQECPRQDQDIAFLIDGSGSIFSSDFNKMLNFVKAVMSQFQRPNSQFSLVQFSSTFKVHFAFKDFATSSDPLSLLNSVQQLQGWTFTASAIRFVTDLLLSAANGARKDASKILIVITDGEKTENLGYKDVIPRAEAAGIIRYAIGVGSAFRYKKSLKELIDIASTPSEEHVFQVENFDALRDIQKQLKEKIFAIEGTQTISSSSFELEMSQEGFSAVFMPDGPVLGAVGSFSWSGGAFLYPPNKNPTFINMSQEHVDMRDSYLGYSTELALWRGAQSLILGAPRHQHTGKVVLFTQVSRQWRPQAEVTGTQIGSYFGASLCSVDVNGDSSSDLILIGAPHFYEQTQGGQVSVCPFPRGRAKWQCDAVLRGEPGHPWGRFGAALTALGDVNGDRLADVAIGAPGEQENQGAVYLFHGTSELGISPSHSQRVTGAQLSPSLQYFGQSLSGGQDLTQDGLADVAVGAQGHALLLRTRPVLRMWANIHITPAEIARSVYECQQLVTFPHDLGKAIVCLQVSQSSKNQLVNLQSIVTFDLTLDPGRLSSRAIFQETGTRNLTRVRELGLKQHCEAVRLLLPDCVEDSVTPIILRLNFSLVGKPISSLRNLQPMLAVDAQRYFTTSLPFEKNCGADHVCQDDLSISFGVSDLKTLIVGSNLELNLKVRVWNDGEDSYGTAVTFFYPPGLSYRRVTGGQSHLQSRSLRLTCDSAPAGTQGTRSTRCSVNHLIFREGAQVTFTVTFHVSPTATLGDKLLLAANVSSENNSPKTSKTAFQLELPVKYAVYTVISSHEQSTKYLNFSASQEEGSREAQHRYQVNNLGQRELPVSIDISVPMELNQVPVWKDIEVLNPQNPSIQCSSERTAPTESDFLTHFKKKPVLDCSIAVCLRFRCDIPSFGIQEELDFILKGNLSFRWVSQTQQKKVLVVSVAEITFNRLVYSQLPGQETFLRAQTELVLEKYEVYNPIPLIVGSSLGGLLLLALITALLYKVGFFKRQYKEMMEGANQQTVPENETETPKLPIPPYLQYNF", "length": 1166, "header": "tr|A0ABI0P146-1|A0ABI0P146_BOVIN Computationally mapped isoform of VWFA domain-containing protein OS=Bos taurus OX=9913 GN=LOC101904063 PE=3 SV=1 CANONICAL=A0A3Q1LZT3-1" }, "locus": { "chromosome": "25", "start_pos": 27418273, "end_pos": 27398592, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145349.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145349.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104180.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104180.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-202733", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-202733", "resource": "Reactome", "description": "Cell surface interactions at the vascular wall" }, { "id": "R-BTA-216083", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "resource": "Reactome", "description": "Integrin cell surface interactions" }, { "id": "R-BTA-3000178", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000178", "resource": "Reactome", "description": "ECM proteoglycans" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZWP3-1", "protein_name": "Integrin subunit alpha X", "gene_name": "Itgax", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSCTWTAFLLLKVFASCLGFNLDAEKPTRFHMDGAEFGHSVVQYGGSWVVVGAPKEIQATNQIGGLYKCGYHTGMCESISLQVPPEAVNMSLGLSLTATNPSWLLACGPTVHHICRENTYLTGLCFLLDSSFRQNQNFPAAQQGCPRQDQDIVFLIDGSGSITYTDFEKMLAFVKAVMSQLQQSSTRFSLMQFSHTFRTHFTFNDFISTSSPLRLLDFVNQLRGSTRTASAIKHVITELFTTQKGARKDATKILIVITDGRKEGDRLDYGDVIPMAEAAGIIRYAIGVGQAFYQAQSRQELKDIASSPSREYVFSVENFDALKDIQNQLKEKIFAIEGTETPSSSSFELEMSQEGFSAVFTPDGPVLGAVGSFGWSGGAFLYPPNTRPTFINMSQENVDMRDSYLGYSTAVAFWKGVHSLILGAPRHQHTGKVVIFTQEARHWRPKSEVRGTQIGSYFGASLCSVDMDRDDSTDLVLIGAPHYYEQTRGGQVSVCPVPGVGSRWQCEATLHGEQGHPWGRFGAALTVLGDVNGDDLADVAIGAPGEEESRGAVYIFHGASRLEISPSPSQRISASRIFPRLQYFGQSLSGGQDLTGDGLVDLAVGSKGHLLLLRTRPILRMSSTIQFTPTEISRSVFECQGQVTREQTLGTATVCLRTYESSKTQRGDLQSIVTFDLALDPGRLSPRAIFKETKTQALTKVRTLGLSSHCEPVTLLLPACVEDSVTPITLRLNFSLVGVPIPSLQNLQPMLAVDEQTYFTASLPFEKNCGADHICQDDLGIIFGFPDLKTLVVGSNLELSVAVTVTNDGEDSYGTTITLFYPVGLSFRRVAEAQVFLRTEDTQQWQQQGRHSLHLMCDSTPDRSQGIWSTSCSSRHVIFRGGSQMTFLVTFDVSPKAELGDRLLLRARVSSENGVPETRKTTFQLELPVKYAVYTVISSHDQFTKYLNFSASEKSRVSVVEHRFQVNNLGQRDLPVSINFRVPTELKGETVWTVMVSHPQNPSTQCYQNRLKPTQFDLLTHMQKSPVLDCSIADCLHFRCDIPSLGIQDELDFILKGNLSFGWISQTLQKKVLLVSEAEISFDTSVYSQLPGQEAFLRAQAKTTLEMYEVHNPVPLIVGSSVGGLLLLALITAVLYKAGFFKRQYKEMLAEANGQFASGNGNPNPQVTQQELPSPSSLNLPS", "length": 1182 }, "evidence": [ { "id": "A0A3Q1LZT3", "url": "https://omabrowser.org/oma/group/A0A3Q1LZT3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P20702-1", "protein_name": "Integrin alpha-X", "gene_name": "ITGAX", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTRTRAALLLFTALATSLGFNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQEQDIVFLIDGSGSISSRNFATMMNFVRAVISQFQRPSTQFSLMQFSNKFQTHFTFEEFRRSSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLDYKDVIPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIFAIEGTETTSSSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEKYKVHNPTPLIVGSSIGGLLLLALITAVLYKVGFFKRQYKEMMEEANGQIAPENGTQTPSPPSEK", 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"pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZT3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT3" } ], "pmid": "" }, { "name": "integrin alphaX-beta2 complex", "id": "GO:0034689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034689", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZT3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT3" } ], "pmid": "" }, { "name": "integrin complex", "id": "GO:0008305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008305", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZT3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZT3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { 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"sequence": "MPPKKGGDGIKPPPIIGRFGTSLKIGIVGLPNVGKSTFFNVLTNSQASAENFPFCTIDPNESRVPVPDERFDFLCQYHKPASKIPAFLNVVDIAGLVKGAHNGQGLGNAFLSHISACDGIFHLTRAFEDDDITHVEGSVDPVRDIEIIHEELQLKDEEMVGPIIDKLEKVAVRGGDKKLKPEYDIMCKVKSWVIDQKKPVRFYHDWNDKEIEVLNKHLFLTSKPMVYLVNLSEKDYIRKKNKCGALELRLQELSAEERQKYLEANMTQSALPKIIKAGFAALQLEYFFTAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDIIFFKFNTPQQPKKK", "length": 375, "header": "tr|A0A3Q1LZU5-1|A0A3Q1LZU5_BOVIN Isoform 1 of Obg-like ATPase 1 OS=Bos taurus OX=9913 GN=OLA1 PE=3 SV=2 CANONICAL=A0A3Q1LZU5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZU5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZU5/entry", "sequence": { "sequence": 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF25772", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M070", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M070", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M070-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M070-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8L3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8L3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNA1", "url": "https://www.uniprot.org/uniprotkb/E1BNA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BNA1-1", "url": "https://www.uniprot.org/uniprotkb/E1BNA1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METDANKEVTSEEEEVERLRTHVGPACILVPRTQSFNLSPCLLGMGRSGKLPSGVSAKLKRWKKGHSSDSNPVICRHRQAARSRFFSRPSGKSDLTVDAVKLHNELQSGSLRLGKSEAPETAMEEEEEVTPAFTEKSSGTFLSGLSDCTNVTFSKVQRFWESNSAAHKEICAVLAAVTEVIRSQGGKETETEYFAALMTTMEAVESTESLAAVAYLLNLVLKRVPSPVLIKKFSDTSKAFVDIMSAQAIGGSTSALRWVLSCLATLLRKQDLEAWSFPVTLQVYHGLLSFTVHTKPKIRRAAQHGVCSILKGSEFMFGEKAPAHHPAAISTAKFCIQEIEKSGGSKEATTMLHMLTLLKDLLPCFPEGLVKSCSETLLRVMTLNHVLVTACAMQAFHSLFHAKPRASTLPAELNAQIITALYDYVPSENDLQPLLAWLKVMEKAHINLVRLHRDLGLGHLPRFFGTATTCLLSPHLPVVTAATQCLQEILKECVAPHMADIGSVTSSASGPSQCIAKMFRAVEEGLTYRFHAAWSSVLQLLCVFFEACGRQAHPVMKKCLQSLCDLRLSPHFPHTAALDRAVGAAVASMGPEVVLEAVPLEIDGSEETLDFPRSWLLPVIRDHVRETRLGFFTAYFLPLATTLKRKAMDLAQAGSTVESKIYDTLQWQIWTLLPGFCTRPTDVATAFKGLARTLGTAISERPDLRVTVCQALRSLVTKGCEAEADRAEVSRFAKNFLPILFNLYGQPTAAGDTPAPRRAVLETIKTYLTITEPQLVNSFLEKASEKVLDASSSDFTRLSVLDLVVALAPHADEAAISKLYSTIRPYLESKTHGIQKKAYRVLEEVCASPQGPGARFVQSHLDDLKKTLLDSLRSTSSPAKRPRLKCLIHVVKKLSAEHEEFISALVPEVILCTKEVSVGARKNAFALLVEMGHAFLRFGPNQEEALQRYLILIYPGLVGAVTMVSCSILALTHLLFEFKGLMGTSTVEQLLENVCLLLASRTRDVVKSALGFIKVAVVVMDVAHMAKHVQLVMEAIGKLSDDMRRHFRMKLRNLFTKFIRKFGFELVKKLLPEEYHKVLVNIRKAESRAKKHRALNQAAVEEEEEEEEEPVQGKGDSIEEILADSEDEEDEEEERSRGKEQRRLARQRSRAWLKEGGGDEPLNFLDPKVAQRVLATQPGPGRGKKKDHGFKVSADGRLIIREEEDANTKMEEEEGAKGEDEEMGDLMEDVGVKSKKHQKLKQKEADDEELEMPPQYQAGGSGIHRPVAKKTIPGAEYKAKKAKGDVKKKGRLDPYAYIPLNRTKLNRRKKMKLQGQFKGLVRAAQRGSHVGHKLRRKDRRP", "length": 1341, "header": "tr|A0A3Q1M070-1|A0A3Q1M070_BOVIN Isoform 1 of Ribosomal RNA processing 12 homolog OS=Bos taurus OX=9913 GN=RRP12 PE=3 SV=2 CANONICAL=A0A3Q1M070-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M070-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M070/entry", "sequence": { "sequence": "METDANKEVTSEEEEVERLRTHVGPACILVPRTQSFNLSPCLLGMGRSGKLPSGVSAKLKRWKKGHSSDSNPVICRHRQAARSRFFSRPSGKSDLTVDAVKLHNELQSGSLRLGKSEAPETAMEEEEEVTPAFTEKSSGTFLSGLSDCTNVTFSKVQRFWESNSAAHKEICAVLAAVTEVIRSQGGKETETEYFAALMTTMEAVESTESLAAVAYLLNLVLKRVPSPVLIKKFSDTSKAFVDIMSAQAIGGSTSALRWVLSCLATLLRKQDLEAWSFPVTLQVYHGLLSFTVHTKPKIRRAAQHGVCSILKGSEFMFGEKAPAHHPAAISTAKFCIQEIEKSGGSKEATTMLHMLTLLKDLLPCFPEGLVKSCSETLLRVMTLNHVLVTACAMQAFHSLFHAKPRASTLPAELNAQIITALYDYVPSENDLQPLLAWLKVMEKAHINLVRLHRDLGLGHLPRFFGTATTCLLSPHLPVVTAATQCLQEILKECVAPHMADIGSVTSSASGPSQCIAKMFRAVEEGLTYRFHAAWSSVLQLLCVFFEACGRQAHPVMKKCLQSLCDLRLSPHFPHTAALDRAVGAAVASMGPEVVLEAVPLEIDGSEETLDFPRSWLLPVIRDHVRETRLGFFTAYFLPLATTLKRKAMDLAQAGSTVESKIYDTLQWQIWTLLPGFCTRPTDVATAFKGLARTLGTAISERPDLRVTVCQALRSLVTKGCEAEADRAEVSRFAKNFLPILFNLYGQPTAAGDTPAPRRAVLETIKTYLTITEPQLVNSFLEKASEKVLDASSSDFTRLSVLDLVVALAPHADEAAISKLYSTIRPYLESKTHGIQKKAYRVLEEVCASPQGPGARFVQSHLDDLKKTLLDSLRSTSSPAKRPRLKCLIHVVKKLSAEHEEFISALVPEVILCTKEVSVGARKNAFALLVEMGHAFLRFGPNQEEALQRYLILIYPGLVGAVTMVSCSILALTHLLFEFKGLMGTSTVEQLLENVCLLLASRTRDVVKSALGFIKVAVVVMDVAHMAKHVQLVMEAIGKLSDDMRRHFRMKLRNLFTKFIRKFGFELVKKLLPEEYHKVLVNIRKAESRAKKHRALNQAAVEEEEEEEEEPVQGKGDSIEEILADSEDEEDEEEERSRGKEQRRLARQRSRAWLKEGGGDEPLNFLDPKVAQRVLATQPGPGRGKKKDHGFKVSADGRLIIREEEDANTKMEEEEGAKGEDEEMGDLMEDVGVKSKKHQKLKQKEADDEELEMPPQYQAGGSGIHRPVAKKTIPGAEYKAKKAKGDVKKKGRLDPYAYIPLNRTKLNRRKKMKLQGQFKGLVRAAQRGSHVGHKLRRKDRRP", "length": 1341, "header": "tr|A0A3Q1M070-1|A0A3Q1M070_BOVIN Isoform 1 of Ribosomal RNA processing 12 homolog OS=Bos taurus OX=9913 GN=RRP12 PE=3 SV=2 CANONICAL=A0A3Q1M070-1" }, "locus": { "chromosome": "26", "start_pos": 18632763, "end_pos": 18604274, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083851.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083851.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061352.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061352.2" } ] } }, { "isoform_ac": "A0AAA9S8L3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8L3/entry", "sequence": { "sequence": "MGRSGKLPSGVSAKLKRWKKGHSSDSNPVICRHRQAARSRFFSRPSGKSDLTVDAVKLHNELQSGSLRLGKSEAPETAMEEEEEVTPAFTEKSSGTFLSGLSDCTNVTFSKVQRFWESNSAAHKEICAVLAAVTEVIRSQGGKETETEYFAALIRRAAQHGVCSILKGSEFMFGEKAPAHHPAAISTAKFCIQEIEKSGGSKEATTMLHMLTLLKDLLPCFPEGLVKSCSETLLRVMTLNHVLVTACAMQAFHSLFHAKPRASTLPAELNAQIITALYDYVPSENDLQPLLAWLKVMEKAHINLVRLHRDLGLGHLPRFFGTATTCLLSPHLPVVTAATQCLQEILKECVAPHMADIGSVTSSASGPSQCIAKMFRAVEEGLTYRFHAAWSSVLQLLCVFFEACGRQAHPVMKKCLQSLCDLRLSPHFPHTAALDRAVGAAVASMGPEVVLEAVPLEIDGSEETLDFPRSWLLPVIRDHVRETRLGFFTAYFLPLATTLKRKAMDLAQAGSTVESKIYDTLQWQIWTLLPGFCTRPTDVATAFKGLARTLGTAISERPDLRVTVCQALRSLVTKGCEAEADRAEVSRFAKNFLPILFNLYGQPTAAGDTPAPRRAVLETIKTYLTITEPQLVNSFLEKASEKVLDASSSDFTRLSVLDLVVALAPHADEAAISKLYSTIRPYLESKTHGIQKKAYRVLEEVCASPQGPGARFVQSHLDDLKKTLLDSLRSTSSPAKRPRLKCLIHVVKKLSAEHEEFISALVPEVILCTKEVSVGARKNAFALLVEMGHAFLRFGPNQEEALQRYLILIYPGLVGAVTMVSCSILALTHLLFEFKGLMGTSTVEQLLENVCLLLASRTRDVVKSALGFIKVAVVVMDVAHMAKHVQLVMEAIGKLSDDMRRHFRMKLRNLFTKFIRKFGFELVKKLLPEEYHKVLVNIRKAESRAKKHRALNQAAVEEEEEEEEEPVQGKGDSIEEILADSEDEEDEEEERSRGKEQRRLARQRSRAWLKEGGGDEPLNFLDPKVAQRVLATQPGPGRGKKKDHGFKVSADGRLIIREEEDANTKMEEEEGAKGEDEEMGDLMEDVGVKSKKHQKLKQKEADDEELEMPPQYQAGGSGIHRPVAKKTIPGAEYKAKKAKGDVKKKGRLDPYAYIPLNRTKLNRRKKMKLQGQFKGLVRAAQRGSHVGHKLRRKDRRP", "length": 1197, "header": "tr|A0AAA9S8L3-1|A0A3Q1M070_BOVIN Computationally mapped isoform of Ribosomal RNA processing 12 homolog OS=Bos taurus OX=9913 GN=RRP12 PE=3 SV=1 CANONICAL=A0A3Q1M070-1" }, "locus": { "chromosome": "26", "start_pos": 18632631, "end_pos": 18604274, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103650.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103650.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082386.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082386.1" } ] } }, { "isoform_ac": "E1BNA1-1", "url": "https://www.uniprot.org/uniprotkb/E1BNA1/entry", "sequence": { "sequence": "MGRSGKLPSGVSAKLKRWKKGHSSDSNPVICRHRQAARSRFFSRPSGKSDLTVDAVKLHNELQSGSLRLGKSEAPETAMEEEEEVTPAFTEKSSGTFLSGLSDCTNVTFSKVQRFWESNSAAHKEICAVLAAVTEVIRSQGGKETETEYFAALVLSCLATLLRKQDLEAWSFPVTLQVYHGLLSFTVHTKPKIRRAAQHGVCSILKGSEFMFGEKAPAHHPAAISTAKFCIQEIEKSGGSKEATTMLHMLTLLKDLLPCFPEGLVKSCSETLLRVMTLNHVLVTACAMQAFHSLFHAKPRASTLPAELNAQIITALYDYVPSENDLQPLLAWLKVMEKAHINLVRLHRDLGLGHLPRFFGTATTCLLSPHLPVVTAATQCLQEILKECVAPHMADIGSVTSSASGPSQCIAKMFRAVEEGLTYRFHAAWSSVLQLLCVFFEACGRQAHPVMKKCLQSLCDLRLSPHFPHTAALDRAVGAAVASMGPEVVLEAVPLEIDGSEETLDFPRSWLLPVIRDHVRETRLGFFTAYFLPLATTLKRKAMDLAQAGSTVESKIYDTLQWQIWTLLPGFCTRPTDVATAFKGLARTLGTAISERPDLRVTVCQALRSLVTKGCEAEADRAEVSRFAKNFLPILFNLYGQPTAAGDTPAPRRAVLETIKTYLTITEPQLVNSFLEKASEKVLDASSSDFTRLSVLDLVVALAPHADEAAISKLYSTIRPYLESKTHGIQKKAYRVLEEVCASPQGPGARFVQSHLDDLKKTLLDSLRSTSSPAKRPRLKCLIHVVKKLSAEHEEFISALVPEVILCTKEVSVGARKNAFALLVEMGHAFLRFGPNQEEALQRYLILIYPGLVGAVTMVSCSILALTHLLFEFKGLMGTSTVEQLLENVCLLLASRTRDVVKSALGFIKVAVVVMDVAHMAKHVQLVMEAIGKLSDDMRRHFRMKLRNLFTKFIRKFGFELVKKLLPEEYHKVLVNIRKAESRAKKHRALNQAAVEEEEEEEEEPVQGKGDSIEEILADSEDEEDEEEERSRGKEQRRLARQRSRAWLKEGGGDEPLNFLDPKVAQRVLATQPGPGRGKKKDHGFKVSADGRLIIREEEDANTKMEEEEGAKGEDEEMGDLMEDVGVKSKKHQKLKQKEADDEELEMPPQYQAGGSGIHRPVAKKTIPGAEYKAKKAKGDVKKKGRLDPYAYIPLNRTKLNRRKKMKLQGQFKGLVRAAQRGSHVGHKLRRKDRRP", "length": 1236, "header": "tr|E1BNA1-1|A0A3Q1M070_BOVIN Computationally mapped isoform of Ribosomal RNA processing 12 homolog OS=Bos taurus OX=9913 GN=RRP12 PE=3 SV=2 CANONICAL=A0A3Q1M070-1" }, "locus": { "chromosome": "26", "start_pos": 18632631, "end_pos": 18604274, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002844.7", "url": "https://www.ensembl.org/id/ENSBTAT00000002844.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002844.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002844.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 753, "start_aa": "Thr", "end_pos": 753, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr753", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:528990", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528990", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M070", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M070" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M070", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M070" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M070", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M070" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M070", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M070" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1301, "end_pos": 1303, "annotation": "n_glycosylation_sequon" }, { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M070", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M070" }, { "id": "PF08161", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08161" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRP12 HEAT", "eco_id": "ECO_0000259", "start_pos": 473, "end_pos": 746, "start_aa": "Ser", "end_aa": "Gln", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1M070", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M070" }, { "id": "PF25772", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25772" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRP12 N-terminal HEAT", "eco_id": "ECO_0000259", "start_pos": 156, "end_pos": 402, "start_aa": "Val", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 753 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1301, "end_pos": 1303 }, { "start_pos": 150, "end_pos": 152 }, { "start_pos": 37, "end_pos": 39 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } 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"PTHR11639", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11639:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11639:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024840002", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840002", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0A1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0A1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2E8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2E8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQLLRNINGIIEAFRRYARMEGDCAVLERGELKRLLEKEFADVIVKPHDPATVDEVLRLLDEDDTGTVEFKEFLVLVFKVAQACFETLSEGPEGVCGSQESGRGAPAATQEPGAGQRSSTAVGRPGNRQGPAGSSDSQSEQASRGPGGPGPQTQGQDISCAQVSHQDRQSESQRQEGVSQSTQARGHVEQAQRMREDKSSQTRERGTERQLQASNQDRAHQTSETITGTITQTRTSATQAVEQDRSHQTGSASTQPRESTRGTETHSQTAETRPQTQIHTHTTEQDRSHQTGSTSTQPRESTRGTETHSQTSQVVTGGHVQAETRPQTQIHTHTTEQDRSHQTGSTSTQPRESTRGTETHSQDGNQTSQVVTGGHVQAETRPQTQIHTHTTEQDRSHQTGSTSTQPQESTRGTETHSQDGRQTSQVVTGGHIQAETRSQTQTHTHTTEQDRSHQTGSASTQPRESTRGTEAHSQDGRQTSQVVTGGHIQAETRSQTQIHTHTLEQDRSHQTGSTSTQPQESTRGTEAHSQSGRQTSQVVTGHIQTQTRSQTQTVEQNRSQQTGSTSTQPRESTRGTETHSQDRNQTSQVVTGGHVQAETRPQTQTHIRTTEQDRSHQTGSASTQPRESTRGTETHSQTAETRPQTQIHTHTTEQDRSHQTGSVSTQPQESTRGTETHSQDRYQTRQVVTGGHIQTQGGAPQAMEQDRGQITRHTGAGEQGQPQRQSGSSQRQTQVSNCEAGETVLGGQAQTGASTVTGRQDRSSTHPPSSATGGQGERDPTVVHQEWVDDHTRETVIRRQDQGSLHASVPSAQGREAAPPDGKRGLTARGLYSYFKSSKP", "length": 841, "header": "tr|A0A3Q1M0A1-1|A0A3Q1M0A1_BOVIN Isoform 1 of Cornulin OS=Bos taurus OX=9913 GN=CRNN PE=3 SV=1 CANONICAL=A0A3Q1M0A1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0A1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A1/entry", "sequence": { "sequence": "MPQLLRNINGIIEAFRRYARMEGDCAVLERGELKRLLEKEFADVIVKPHDPATVDEVLRLLDEDDTGTVEFKEFLVLVFKVAQACFETLSEGPEGVCGSQESGRGAPAATQEPGAGQRSSTAVGRPGNRQGPAGSSDSQSEQASRGPGGPGPQTQGQDISCAQVSHQDRQSESQRQEGVSQSTQARGHVEQAQRMREDKSSQTRERGTERQLQASNQDRAHQTSETITGTITQTRTSATQAVEQDRSHQTGSASTQPRESTRGTETHSQTAETRPQTQIHTHTTEQDRSHQTGSTSTQPRESTRGTETHSQTSQVVTGGHVQAETRPQTQIHTHTTEQDRSHQTGSTSTQPRESTRGTETHSQDGNQTSQVVTGGHVQAETRPQTQIHTHTTEQDRSHQTGSTSTQPQESTRGTETHSQDGRQTSQVVTGGHIQAETRSQTQTHTHTTEQDRSHQTGSASTQPRESTRGTEAHSQDGRQTSQVVTGGHIQAETRSQTQIHTHTLEQDRSHQTGSTSTQPQESTRGTEAHSQSGRQTSQVVTGHIQTQTRSQTQTVEQNRSQQTGSTSTQPRESTRGTETHSQDRNQTSQVVTGGHVQAETRPQTQTHIRTTEQDRSHQTGSASTQPRESTRGTETHSQTAETRPQTQIHTHTTEQDRSHQTGSVSTQPQESTRGTETHSQDRYQTRQVVTGGHIQTQGGAPQAMEQDRGQITRHTGAGEQGQPQRQSGSSQRQTQVSNCEAGETVLGGQAQTGASTVTGRQDRSSTHPPSSATGGQGERDPTVVHQEWVDDHTRETVIRRQDQGSLHASVPSAQGREAAPPDGKRGLTARGLYSYFKSSKP", "length": 841, "header": "tr|A0A3Q1M0A1-1|A0A3Q1M0A1_BOVIN Isoform 1 of Cornulin OS=Bos taurus OX=9913 GN=CRNN PE=3 SV=1 CANONICAL=A0A3Q1M0A1-1" }, "locus": { "chromosome": "3", "start_pos": 18286306, "end_pos": 18282677, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085981.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085981.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063053.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063053.1" } ] } }, { "isoform_ac": "A0AAA9T2E8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E8/entry", "sequence": { "sequence": "MPQLLRNINGIIEAFRRYARMEGDCAVLERGELKRLLEKEFADVIVKPHDPATVDEVLRLLDEDDTGTVEFKEFLVLVFKVAQACFETLSEGPEGVCGSQESGRGAPAATQEPGAGQRSSTAVGRPGNRQGPAGSSDSQSEQASRGPGGPGPQTQGQDISCAQVSHQDRQSESQRQEGVSQSTQARGHVEQAQRMREDKSSQTRERGTERQLQASNQDRAHQTSETITGTITQTRTSATQAVEQDRSHQTGSASTQPRESTRGTETHSQTAETRPQTQIHTHTTEQDRSHQTGSTSTQPRESTRGTETHSQTSQVVTGGHVQAETRPQTQIHTHTTEQDRSHQTGSTSTQPRESTRGTETHSQDGNQTSQVVTGGHVQAETRPQTQIHTHTTEQDRSHQTGSTSTQPQESTRGTETHSQDGRQTSQVVTGGHIQAETRSQTQIHTHTLEQDRSHQTGSTSTQPQESTRGTEAHSQSGRQTSQVVTGHIQTQTRSQTQTVEQNRSQQTGSTSTQPRESTRGTETHSQDRNQTSQVVTGGHVQAETRPQTQTHIRTTEQDRSHQTGSASTQPRESTRGTETHSQTAETRPQTQIHTHTTEQDRSHQTGSVSTQPQESTRGTETHSQDRYQTRQVVTGGHIQTQGGAPQAMEQDRGQITRHTGAGEQGQPQRQSGSSQRQTQVSNCEAGETVLGGQAQTGASTVTGRQDRSSTHPPSSATGGQGERDPTVVHQEWVDDHTRETVIRRQDQGSLHASVPSAQGREAAPPDGKRGLTARGLYSYFKSSKP", "length": 785, "header": "tr|A0AAA9T2E8-1|A0A3Q1M0A1_BOVIN Computationally mapped isoform of Cornulin OS=Bos taurus OX=9913 GN=CRNN PE=3 SV=1 CANONICAL=A0A3Q1M0A1-1" }, "locus": { "chromosome": "3", "start_pos": 18286306, "end_pos": 18282677, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103891.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103891.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090807.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090807.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287AM19-1", "protein_name": "Cornulin", "gene_name": "CRNN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPQLLRNINGIIEAFRRYARTEGDCAVLTRGELKRLLEQELADVIVKPHDPATVDEVLRLLDEDDTGTVEFKEFLVLVFKVAQACFRTLSESPEGACGSQESGSRVSAASQDLGGGQRSSTSVGRVGRGQDHAGSGSAQSEQASRGQGGPGPQTQGQDISAAQVSHQDNQSESQRQEGTSQLTQARGHVEQPQRVCKDRSPQTRERDEEGQPQTREQDRAPQTSGTVTGTRTQTQTHTQTEEQDRSHQTGSTSVQPQESTYGQTRETEIHGQDGSQTSQVGTGGHIQTQAGSQTQTVEQDRSHQTGSASIQPQEPTYGQTRGTEIHSQDRGQTSQVVTGGHVQTQAGSQTQTHTQIAEQDSSLQTGSASIQPQEPTYGQTRGTETHSQYRSQTSQVVTGGHVQTQRSVTQIVEQNRSHQTGHATIQAQEFASGQTRGTVTNGQDRSQTNQVVIGGHFQTQEGGTQTVEQGSSHQTGSASIQPQEPTCGQTRGTETHSQDRSQTSQVVTGGYVQTQGITGTVEQESSQTAGHTGARDQGQTERQSDSGQRQTQESSNAAGETVLGGQAQTGASTPTGRQDGCSTHPTCRVTGGQGESEPTTEVKQEWVDDLAGETVIPRQDQGSLHTRVPSAQGGEAAQPEGNRGLTARGLYSYFRSGKL", "length": 659 }, "evidence": [ { "id": "A0A3Q1M0A1", "url": "https://omabrowser.org/oma/group/A0A3Q1M0A1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3YUU6-1", "protein_name": "Cornulin", "gene_name": "Crnn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPQLLQNIHGIIEAFGCYARSEGGCKVLTRQELKRLLEHEFADVIVKPHDPATVDEVLRLLDEDNTGTVEFKEFLVLVFKVARACFKTLNESPKGACISDKSEGCYSGSSKELEQRQRGGAEVAKDGAAQHCEDSSCGQRDQASRGQDRVGTHTQNQDSYPTQVSSHDRQTESQTQEMISQQTQVTGQVEQTPRTEDKSWTRQKRSERQPQSSQQTDEITTGSTAQTQAGNFYTQGSTCDYNRGTNSHHQDRSHADRASTQHYQTQAGSHTQIHTQMVEQAWGQQTGSDSIQTQGSIYDQSTETVIHGQDRNQASQSVKEHHQAQGESYIQTHTQTMEQGRSQQAENSSTQTHGSMYGQNRETEIHGLESSQAEQVGTRHYQTQAGSYTQTLEHDGSQSAHKFVAQEKERTQTKPCMGQSWTPVSNYETEESVIGGQVQTETDTIIENHPSPTARQVERVPTVVREEWVNDHTREIVIRSQDPGSLHSGTPSAQGQDIPQMEKKGITAKGLYTYLKTEQP", "length": 520 }, "evidence": [ { "id": "A0A3Q1M0A1", "url": "https://omabrowser.org/oma/group/A0A3Q1M0A1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZSW4-1", "protein_name": "Cornulin", "gene_name": "Crnn", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPQLLRNIHGIIEAFGCYARSEGGCKVLTKQELKRLLEYEFADVIVKPHDPATVDEVLHLLDEDNTGTVEFKEFLVLVFKVARACFKTLNESPKGACMSDKSESCHVGSSKELEQGQRGGAEVAKDGAAQHCENSSCGQRDQASRGQDRVGTHTQHQDSYPTWVSSHDRQAESQTQEMISQQTQVTGPVEQTPKIEDKSCIGQKRSERQPQISQQTDEITTESTTQTQAGTFYTQGSTCDQNRGTNSLTQDRSQTDQASTQHYQTRAGSHTQIHNQTVEQGWGQQTGKNNIQIQGSIYDQSRETEIRGQDRNQASQTAKEHHQAQAESYTRAHTQTMEQGRSQQEENGSIQTHASICGQNRGTKIHEQESNQVEQVGTGHCQTQAGSDAQTLEHNGSHSARQVVAQEKGQMQTQSCMGQSWTPVSNYETGEPVLGQVQTEIDTVKERQPWNSNHPSLAGRQGERSPTVVREEWVNDHTREIVIRSQDPGSLHSGAPSAQGQDTAQMEKKGITAKGLYSYLKTEQP", "length": 525 }, "evidence": [ { "id": "A0A3Q1M0A1", "url": "https://omabrowser.org/oma/group/A0A3Q1M0A1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UBG3-1", "protein_name": "Cornulin", "gene_name": "CRNN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPQLLQNINGIIEAFRRYARTEGNCTALTRGELKRLLEQEFADVIVKPHDPATVDEVLRLLDEDHTGTVEFKEFLVLVFKVAQACFKTLSESAEGACGSQESGSLHSGASQELGEGQRSGTEVGRAGKGQHYEGSSHRQSQQGSRGQNRPGVQTQGQATGSAWVSSYDRQAESQSQERISPQIQLSGQTEQTQKAGEGKRNQTTEMRPERQPQTREQDRAHQTGETVTGSGTQTQAGATQTVEQDSSHQTGRTSKQTQEATNDQNRGTETHGQGRSQTSQAVTGGHAQIQAGTHTQTPTQTVEQDSSHQTGSTSTQTQESTNGQNRGTEIHGQGRSQTSQAVTGGHTQIQAGSHTETVEQDRSQTVSHGGAREQGQTQTQPGSGQRWMQVSNPEAGETVPGGQAQTGASTESGRQEWSSTHPRRCVTEGQGDRQPTVVGEEWVDDHSRETVILRLDQGNLHTSVSSAQGQDAAQSEEKRGITARELYSYLRSTKP", "length": 495 }, "evidence": [ { "id": "A0A3Q1M0A1", "url": "https://omabrowser.org/oma/group/A0A3Q1M0A1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051896", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0A1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "transition metal ion binding", "id": "GO:0046914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046914", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0A1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A1" } ], "pmid": "" }, { "name": "calcium-dependent protein binding", "id": "GO:0048306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048306", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0A1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A1" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0A1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 366, "end_pos": 368, "annotation": "n_glycosylation_sequon" }, { "start_pos": 558, "end_pos": 560, "annotation": "n_glycosylation_sequon" }, { "start_pos": 585, "end_pos": 587, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M0A1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 841, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M0A1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0A1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M0A1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A1" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 84, "start_aa": "His", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 366, "end_pos": 368 }, { "start_pos": 558, "end_pos": 560 }, { "start_pos": 585, "end_pos": 587 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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"MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLFGEDPITFAPFKISCEAEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGTQKITDGVNEVNTENMISSTDHDKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQPSTDLNRNYSKSMELTGKNESTIDQIDKKLERNLSFEIKKVPLQEGPRSFDGNTLLNRGHAIKIKSASASPCTVDKISKSQELSSRDLKVDDISQNSCVDCNATQSNKDPIILPEASQKNSDTPPRPDHLPLDGKGHLTWSFHGPENTLPMPDSSEGKSSDIHCQTMKTVSSTPSPTIQVETHDLADHHDSSPLFRAPLSFTNPLHSDDSDSDERNSDGSVTKNKTSISTASATVSAATSSISTRKVLPMSIARHDIAGTIHSGAEKDVDVSEDSPPPLPERTPESFVLANEHNTSVRAEWSELQNQEQSEQKNPEGLITSGSETCDHPAQGIHTETCTECPPTVSNKKDQLSEGPTEATEIGFGNRCGKPKGPRDPPSEWT", "length": 782, "header": "tr|A0A3Q1M0B4-1|A0A3Q1M0B4_BOVIN Isoform 1 of protein-tyrosine-phosphatase OS=Bos taurus OX=9913 GN=PTPN12 PE=3 SV=1 CANONICAL=A0A3Q1M0B4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0B4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4/entry", "sequence": { "sequence": "MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLFGEDPITFAPFKISCEAEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGTQKITDGVNEVNTENMISSTDHDKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQPSTDLNRNYSKSMELTGKNESTIDQIDKKLERNLSFEIKKVPLQEGPRSFDGNTLLNRGHAIKIKSASASPCTVDKISKSQELSSRDLKVDDISQNSCVDCNATQSNKDPIILPEASQKNSDTPPRPDHLPLDGKGHLTWSFHGPENTLPMPDSSEGKSSDIHCQTMKTVSSTPSPTIQVETHDLADHHDSSPLFRAPLSFTNPLHSDDSDSDERNSDGSVTKNKTSISTASATVSAATSSISTRKVLPMSIARHDIAGTIHSGAEKDVDVSEDSPPPLPERTPESFVLANEHNTSVRAEWSELQNQEQSEQKNPEGLITSGSETCDHPAQGIHTETCTECPPTVSNKKDQLSEGPTEATEIGFGNRCGKPKGPRDPPSEWT", "length": 782, "header": "tr|A0A3Q1M0B4-1|A0A3Q1M0B4_BOVIN Isoform 1 of protein-tyrosine-phosphatase OS=Bos taurus OX=9913 GN=PTPN12 PE=3 SV=1 CANONICAL=A0A3Q1M0B4-1" }, "locus": { "chromosome": "4", "start_pos": 43690559, "end_pos": 43600117, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068950.1", "url": "https://www.ensembl.org/id/ENSBTAT00000068950.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063394.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063394.1" } ] } }, { "isoform_ac": "A0A3Q1MEV4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEV4/entry", "sequence": { "sequence": "MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLFGEDPITFAPFKISCEAEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKNEVNTENMISSTDHDKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQPSTDLNRNYSKSMELTGKNESTIDQIDKKLERNLSFEIKKVPLQEGPRSFDGNTLLNRGHAIKIKSASASPCTVDKISKSQELSSRDLKVDDISQNSCVDCNATQSNKDPIILPEASQKNSDTPPRPDHLPLDGKGHLTWSFHGPENTLPMPDSSEGKSSDIHCQTMKTVSSTPSPTIQVETHDLADHHDSSPLFRAPLSFTNPLHSDDSDSDERNSDGSVTKNKTSISTASATVSAATSSISTRKVLPMSIARHDIAGTIHSGAEKDVDVSEDSPPPLPERTPESFVLANEHNTSVRAEWSELQNQEQSEQKNPEGLITSGSETCDHPAQGIHTETCTECPPTVSNKKDQLSEGPTEATEIGFGNRCGKPKGPRDPPSEWT", "length": 749, "header": "tr|A0A3Q1MEV4-1|A0A3Q1M0B4_BOVIN Computationally mapped isoform of protein-tyrosine-phosphatase OS=Bos taurus OX=9913 GN=PTPN12 PE=3 SV=2 CANONICAL=A0A3Q1M0B4-1" }, "locus": { "chromosome": "4", "start_pos": 43690559, "end_pos": 43600117, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069268.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069268.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072696.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072696.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 757, "start_aa": "Thr", "end_pos": 757, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr757", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:531877", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531877", "resource": "KEGG Pathway" }, { "id": "R-BTA-1250196", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1250196", "resource": "Reactome", "description": "SHC1 events in ERBB2 signaling" }, { "id": "R-BTA-186797", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-186797", "resource": "Reactome", "description": "Signaling by PDGF" }, { "id": "R-BTA-8863795", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8863795", "resource": "Reactome", "description": "Downregulation of ERBB2 signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "P35831-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 12", "gene_name": "Ptpn12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEQVEILRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCENEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGNEITTGTMVSSIDSEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDSDRYHPKPVLHMASPEQHPADLNRSYDKSADPMGKSESAIEHIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASSSVVDRTSKPQELSAGALKVDDVSQNSCADCSAAHSHRAAESSEESQSNSHTPPRPDCLPLDKKGHVTWSLHGPENATPVPDSPDGKSPDNHSQTLKTVSSTPNSTAEEEAHDLTEHHNSSPLLKAPLSFTNPLHSDDSDSDGGSSDGAVTRNKTSISTASATVSPASSAESACTRRVLPMSIARQEVAGTPHSGAEKDADVSEESPPPLPERTPESFVLADMPVRPEWHELPNQEWSEQRESEGLTTSGNEKHDAGGIHTEASADSPPAFSDKKDQITKSPAEVTDIGFGNRCGKPKGPREPPSEWT", "length": 775 }, "evidence": [ { "id": "A0A3Q1M0B4", "url": "https://omabrowser.org/oma/group/A0A3Q1M0B4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q05209-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 12", "gene_name": "PTPN12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEWT", "length": 780 }, "evidence": [ { "id": "A0A3Q1M0B4", "url": "https://omabrowser.org/oma/group/A0A3Q1M0B4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ], "pmid": "" }, { "name": "podosome", "id": "GO:0002102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002102", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "SH3 domain binding", "id": "GO:0017124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ], "pmid": "" }, { "name": "non-membrane spanning protein tyrosine phosphatase activity", "id": "GO:0004726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004726", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cellular response to epidermal growth factor stimulus", "id": "GO:0071364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071364", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ], "pmid": "" }, { "name": "regulation of epidermal growth factor receptor signaling pathway", "id": "GO:0042058", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042058", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 408, "end_pos": 410, "annotation": "n_glycosylation_sequon" }, { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 433, "end_pos": 435, "annotation": "n_glycosylation_sequon" }, { "start_pos": 502, "end_pos": 504, "annotation": "n_glycosylation_sequon" }, { "start_pos": 624, "end_pos": 626, "annotation": "n_glycosylation_sequon" }, { "start_pos": 694, "end_pos": 696, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1ME76-1", "F1MRH9-1", "A0AAF6DLF7-1", "A0AAA9S9Q3-1", "E1BFE2-1", "E1BL76-1", "G3MXS7-1", "A0A3Q1LUB1-1", "A0AAA9THG9-1", "F1N339-1", "F6RY99-1", "A0AAF6YUC8-1", "A0AAA9RTM1-1", "A0AAA9SMJ6-1", "A0A3Q1LZA9-1", "A7MBD1-1", "A5D7P0-1", "Q58DB6-1", "A0AAA9SEK4-1", "E1BDH9-1", "F1MGK4-1", "E1BIH4-1", "A0A3Q1M6K1-1", "E1BIU8-1", "A7MBJ4-1", "A6H730-1", "A0A3Q1MFX2-1", "A0AAA9U0H6-1", "A2VDT1-1", "E1BPU9-1", "P0C591-1", "P11064-1", "Q0IID7-1", "Q2KJ36-1", "Q2T9S4-1", "E1BPA0-1", "A0AAA9TAZ9-1", "Q5BIP9-1", "A0A3Q1M5K4-1", "F1MM08-1", "E1BJR7-1", "Q17QJ3-1", "Q17QM8-1", "F1MD22-1", "F1MI99-1", "F1MP34-1", "F1MGK5-1", "F1MEZ2-1", "F1MQM7-1", "E1BEZ8-1", "A0A3Q1M0B4-1", "A0AAA9S7W5-1", "A0A3Q1N8V6-1", "A0AAA9TFV5-1", "A0A3Q1MBB1-1", "F1MTZ3-1", "A0AAF6Z8C2-1", "F1MDF1-1", "A0AAA9T5N9-1", "E1BKT4-1", "A0A3Q1MH98-1", "F1N6L3-1", "F1MW70-1", "F1MXF2-1", "A0AAA9TWD1-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] }, { "id": "R-BTA-8863804", "name": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N758-1", "A0AAA9SBR4-1", "A0A3Q1M0B4-1" ], "evidence": [ { "id": "R-BTA-8863804", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8863804" } ] }, { "id": "R-BTA-8864036", "name": "PTPN12 dephosphorylates PDGFRB at Y1021", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MX49-1", "A0A3Q1M0B4-1", "F1N759-1" ], "evidence": [ { "id": "R-BTA-8864036", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8864036" } ] }, { "id": "R-BTA-8934465", "name": "SHC1 binds PTPN12", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M0B4-1" ], "evidence": [ { "id": "R-BTA-8934465", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8934465" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUB1", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] } ] }, { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B4", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": 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"A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1N8V6", "gene_name": "LOC101903026", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = 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"ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SBR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBR4" } ] } ] }, { "uniprot_ac": "A0AAA9SEK4", "gene_name": "PTPRE", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] } ] }, { "uniprot_ac": "A0AAA9SMJ6", "gene_name": "PTPRH", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] } ] }, { "uniprot_ac": "A0AAA9T5N9", "gene_name": "", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] } ] }, { "uniprot_ac": "A0AAA9TAZ9", "gene_name": 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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", 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"evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YUC8", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] } ] }, { "uniprot_ac": "A0AAF6Z8C2", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ] }, { "uniprot_ac": "A2VDT1", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] } ] }, { "uniprot_ac": "A5D7P0", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "A7MBJ4", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] } ] }, { "uniprot_ac": "E1BDH9", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] } ] }, { "uniprot_ac": "E1BEZ8", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] } ] }, { "uniprot_ac": "E1BFE2", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] } ] }, { "uniprot_ac": "E1BIH4", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] } ] }, { "uniprot_ac": "E1BIU8", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] } ] }, { "uniprot_ac": "E1BJR7", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] } ] }, { "uniprot_ac": "E1BKT4", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] } ] }, { "uniprot_ac": "E1BL76", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] } ] }, { "uniprot_ac": "E1BPA0", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] } ] }, { "uniprot_ac": "E1BPU9", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] } ] }, { "uniprot_ac": "F1MD22", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] } ] }, { "uniprot_ac": "F1MDF1", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MGK4", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] } ] }, { "uniprot_ac": "F1MGK5", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MRH9", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] } ] }, { "uniprot_ac": "F1MTZ3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1MX49", "gene_name": "PDGFRA", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MX49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX49" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MX49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX49" } ] } ] }, { "uniprot_ac": "F1MXF2", "gene_name": "MDP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] } ] }, { "uniprot_ac": "F1N339", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] } ] }, { "uniprot_ac": "F1N6L3", "gene_name": "PTPN22", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] } ] }, { "uniprot_ac": "F1N758", "gene_name": "ERBB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N758" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N758" } ] } ] }, { "uniprot_ac": "F1N759", "gene_name": "PDGFRB", "activity": [ { "ec_number": "2.7.10.1", 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"Other" ] }, { "id": "A0A3Q1M0B8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0B8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALGLPSAALLFLASALICSEHYSLFSERSRRGSSWEQAGGLGWPEAVSRRPRGQKAREAHAKDCGIAPLMHMFKGSRIVGGTEAQTGAWPWLVSLQIHSGRFGAHVCAGSLVKNRWVLTAAHCTKDARNPVIWRAVIGTNNIKGSEPYSKKIKVNAIIIHPDFNVESYDNDIALFHLKKAVRYNNYIQPICLPFGVFQRLNKNTTCFISGWGRTKEEGNVTKELHEAEVHYISRSFCNSERSYGGIVPNTSICAGDEDGIFDSCRGDSGGPLMCYLPERKRYFVMGITSYGYGCGRKNFPGVYSAPSFNQKWLTEQLYQSSNKGILNINILLGQVLIALGSVVLLATP", "length": 349, "header": "tr|A0A3Q1M0B8-1|A0A3Q1M0B8_BOVIN Isoform 1 of Transmembrane serine protease 12 OS=Bos taurus OX=9913 GN=TMPRSS12 PE=4 SV=2 CANONICAL=A0A3Q1M0B8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0B8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B8/entry", "sequence": { "sequence": "MALGLPSAALLFLASALICSEHYSLFSERSRRGSSWEQAGGLGWPEAVSRRPRGQKAREAHAKDCGIAPLMHMFKGSRIVGGTEAQTGAWPWLVSLQIHSGRFGAHVCAGSLVKNRWVLTAAHCTKDARNPVIWRAVIGTNNIKGSEPYSKKIKVNAIIIHPDFNVESYDNDIALFHLKKAVRYNNYIQPICLPFGVFQRLNKNTTCFISGWGRTKEEGNVTKELHEAEVHYISRSFCNSERSYGGIVPNTSICAGDEDGIFDSCRGDSGGPLMCYLPERKRYFVMGITSYGYGCGRKNFPGVYSAPSFNQKWLTEQLYQSSNKGILNINILLGQVLIALGSVVLLATP", "length": 349, "header": "tr|A0A3Q1M0B8-1|A0A3Q1M0B8_BOVIN Isoform 1 of Transmembrane serine protease 12 OS=Bos taurus OX=9913 GN=TMPRSS12 PE=4 SV=2 CANONICAL=A0A3Q1M0B8-1" }, "locus": { "chromosome": "5", "start_pos": 29084835, "end_pos": 29049129, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074826.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074826.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063399.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063399.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], 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"annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M0B8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 349, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M0B8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0B8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M0B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B8" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 79, "end_pos": 319, "start_aa": "Ile", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 204, "end_pos": 206 }, { "start_pos": 220, "end_pos": 222 }, { "start_pos": 250, "end_pos": 252 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M0B9-1", "uniprot_ac": "A0A3Q1M0B9", "uniprot_id": "A0A3Q1M0B9_BOVIN", "mass": { "chemical_mass": 82746.0, "monoisotopic_mass": 82746.0 }, "refseq": {}, "gene_names": [ { "name": "RASEF", "type": "recommended", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ], "protein_names": [ { "name": "Ras and EF-hand domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9/entry#names_and_taxonomy" } ] }, { "name": "3.6.5.2", "type": "synonym", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9/entry#names_and_taxonomy" } ] }, { "name": "Ras-related protein Rab-45", "type": "synonym", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Rab GTPase that acts as a dynein adapter protein, thereby activating dynein-mediated transport and dynein-dynactin motility on microtubules. RASEF-mediated dynein motility is Ca(2+)-independent. Also regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9#function" }, { "database": "UniProtKB", "id": "ARBA00094439", "url": "https://www.uniprot.org/uniprotkb/ARBA00094439#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RASEF", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9", "locus": { "chromosome": "8", "start_pos": 76173243, "end_pos": 76268340, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021751", "url": "https://www.ensembl.org/id/ENSBTAG00000021751" } ] } } ], "crossref": [ { "id": "A0A3Q1M0B9", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0B9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021751", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021751", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00154", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00154", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513223", "url": "https://www.ncbi.nlm.nih.gov/gene/513223", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FIGHSPQ", "url": "https://omabrowser.org/oma/group/FIGHSPQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0B9", "url": "https://www.orthodb.org/?gene=A0A3Q1M0B9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6QVB9", "url": "https://www.orthodb.org/?gene=F6QVB9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47977", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47977", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M0B9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0B9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QVB9", "url": "https://www.uniprot.org/uniprotkb/F6QVB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QVB9-1", "url": "https://www.uniprot.org/uniprotkb/F6QVB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEADGDLKELARLRSVFAACDANRSGRLEREEFRALCAELRVRPADAEAVFQRLDADRDGAITFQEFARGFRGARRVGPRRGWGPREPAPAAAQVGSDSGSGEEDEGDEDAAAALAAPWDPASSGQAWQDFQARLGDEVKFIPRKEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIKLQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLKKLEEQSKHISQKQDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDSLKSDYADQSLNSERDLEIIREYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSCSKLSRALRINNISPGNTVSRSSPKFNLHSPQPLGYDRSSRSSYMDEDCDSLALCDPMQRMNCDVDSLPESCFDSGLSTLRDSNEYDSEVEYKHQRGFQRSHGMQESFGGDASDTDVPDIRDEETYGSEGVASILDWKPPGSASEGSIISSSRKPISALSPQTDMVDESHKSSSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRGNTSATLGVDFQMKMLIVDGERTVLQLWDTAGQERFRSIAKSYFRRADGVLLLYDVTCEKSFLNVREWVDMIEDAAHESIPIMLVGNKADLRDTAEAEGQKCVPGYFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDEDDSKSITNLSGTSSKKSTQMKNCCNG", "length": 740, "header": "tr|A0A3Q1M0B9-1|A0A3Q1M0B9_BOVIN Isoform 1 of Ras and EF-hand domain-containing protein OS=Bos taurus OX=9913 GN=RASEF PE=3 SV=1 CANONICAL=A0A3Q1M0B9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0B9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9/entry", "sequence": { "sequence": "MEADGDLKELARLRSVFAACDANRSGRLEREEFRALCAELRVRPADAEAVFQRLDADRDGAITFQEFARGFRGARRVGPRRGWGPREPAPAAAQVGSDSGSGEEDEGDEDAAAALAAPWDPASSGQAWQDFQARLGDEVKFIPRKEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIKLQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLKKLEEQSKHISQKQDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDSLKSDYADQSLNSERDLEIIREYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSCSKLSRALRINNISPGNTVSRSSPKFNLHSPQPLGYDRSSRSSYMDEDCDSLALCDPMQRMNCDVDSLPESCFDSGLSTLRDSNEYDSEVEYKHQRGFQRSHGMQESFGGDASDTDVPDIRDEETYGSEGVASILDWKPPGSASEGSIISSSRKPISALSPQTDMVDESHKSSSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRGNTSATLGVDFQMKMLIVDGERTVLQLWDTAGQERFRSIAKSYFRRADGVLLLYDVTCEKSFLNVREWVDMIEDAAHESIPIMLVGNKADLRDTAEAEGQKCVPGYFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDEDDSKSITNLSGTSSKKSTQMKNCCNG", "length": 740, "header": "tr|A0A3Q1M0B9-1|A0A3Q1M0B9_BOVIN Isoform 1 of Ras and EF-hand domain-containing protein OS=Bos taurus OX=9913 GN=RASEF PE=3 SV=1 CANONICAL=A0A3Q1M0B9-1" }, "locus": { "chromosome": "8", "start_pos": 76268071, "end_pos": 76176739, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086244.1", "url": "https://www.ensembl.org/id/ENSBTAT00000086244.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061407.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061407.1" } ] } }, { "isoform_ac": "F6QVB9-1", "url": "https://www.uniprot.org/uniprotkb/F6QVB9/entry", "sequence": { "sequence": "MEADGDLKELARLRSVFAACDANRSGRLEREEFRALCAELRVRPADAEAVFQRLDADRDGAITFQEFARGFRGARRVGPRRGWGPREPAPAAAQVGSDSGSGEEDEGDEDAAAALAAPWDPASSGQAWQDFQARLGDEVKFIPRKEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIKLQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLKKLEEQSKHISQKQDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDSLKSDYADQSLNSERTANRKLHDSNDGLRSALENSCSKLSRALRINNISPGNTVSRSSPKFNLHSPQPLGYDRSSRSSYMDEDCDSLALCDPMQRMNCDVDSLPESCFDSGLSTLRDSNEYDSEVEYKHQRGFQRSHGMQESFGGDASDTDVPDIRDEETYGSEGVASILDWKPPGSASEGSIISSSRKPISALSPQTDMVDESHKSSSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRGNTSATLGVDFQMKMLIVDGERTVLQLWDTAGQERFRSIAKSYFRRADGVLLLYDVTCEKSFLNVREWVDMIEDAAHESIPIMLVGNKADLRDTAEAEGQKCVPGYFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDEDDSKSITNLSGTSSKKSTQMKNCCNG", "length": 717, "header": "tr|F6QVB9-1|A0A3Q1M0B9_BOVIN Computationally mapped isoform of Ras and EF-hand domain-containing protein OS=Bos taurus OX=9913 GN=RASEF PE=3 SV=1 CANONICAL=A0A3Q1M0B9-1" }, "locus": { "chromosome": "8", "start_pos": 76268071, "end_pos": 76176739, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028993.7", "url": "https://www.ensembl.org/id/ENSBTAT00000028993.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028993.6", "url": "https://www.ensembl.org/id/ENSBTAP00000028993.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "B8JLE6-1", "protein_name": "Ras and EF-hand domain-containing protein", "gene_name": "rasef", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGSEAQMQRLRELFHACDVDHSGRIEKWEFEKICSELHVQSSEIDSLFSRLDTDEDGTINLEEFMEGFQESHLLKEPEMSGEPAGETSSAAWEDFKSRLGDQFKFIPRIDQVATLYQNIRLTEPRMVPQYERVLVSFIKEIRILNTEMEHLALAVKRAQDQMSMQLSEMEEEMDHRIHTAERNTRLQESKKAEATLSSMKHQYDSQICELQQKIQTLQMMENQNRSVSLKEETSALKRQNNELMLQNQKLKQELLESHTNVAFLQSELDSLKSDLTDQSINCERDEALMKCFSEERDNLERQIEMLQVANRKLHDSNDSLRTALESSQSKSKTQRVSGLSPGVYVNTRKNVCHSYFDRCCNTCVDEEDYDQFRLMAGMRRQSCDSLALALCDPMRRRSCEEDSLPDSGMSTLRSNIGYDYEHERTSSPVEAEDSNTTVSGDTSDTEVVEMREEAASGSDSESVQSWMPSKPVQTDDVSASGKKCLSAIFTEREQDELAVSQSPSEKAYRIVLAGDAAVGKSSFLLRLCKNEFKGNTSATLGVDFQMKTLVVDGVPTVLQLWDTAGQERFRSIAKSYFRRADGVLLLYDVTCEKSFLNVREWVDIIEDVSQDDIPIMLVGNKTDLRKEALQDGVTCIPTSYGEKLAMTYSALFCETSAKDGSNIIEAVLHLAREVTKHADDYKEPVSVAKLSGNHTKKMSSPNCCMG", "length": 706 }, "evidence": [ { "id": "A0A3Q1M0B9", "url": "https://omabrowser.org/oma/group/A0A3Q1M0B9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1LVA5-1", "protein_name": "Ras and EF-hand domain-containing protein", "gene_name": "Rasef", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQLLGISEINMIINMKLENKVFRWRNRPDLLHGPSLGARSPAVASGAMEADADPEELARLRSVFTTYDTNCSGRLERAEFRTLCAELHVAEAEAEAVFLGLDTDRDGAITFPEFARGFRGALGQDSGEAQGLWDAVEPESPGPAWRDFHTRLGEEAQLIPRKEQVSTLYQNINLVEPRLIQPYEHVIRNFLREIRLQSTEMENLAIAVKRAQDKAAIQLSELEEEMDQRIQAVENETRKDEKRKAEEALTDLRRQYETEVGDLQVTIKRLKKLEEQSRKISQKQDVTSLKKQIYDLTTENQKLKKDLLETQTNLAFLQSELDALKSDYADQTMNSERDLELIREFNEDRSNLERQIEVLQTANRKLHDSNDGLRSALENTYSKLTKSLRMNNISPGNTISSSSPKFNHHSSQPLGYDRSSHSSYADEDCDCLALCDPLQKMNYEVDSLPESCFDSGLSTLRDSNECDSEVDYKPQEGFQSLHRTEESLEGDTSDTDVPDMRDEETFDCESVASVLHGHPQGSAGEGSTVSSSRKTISALSPETDMVNNTLKSTSQKAYKIVLAGDAAVGKSSFLMRLCKNEFQGNTSATLGVDFQMKTLMVDGEPTVLQLWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNVREWVAMVEDGTHRSVPIMLVGNKADLRDAATAENQKCISSHLGEKLAMTYGALFCETSAKDGSNVVEAVLHLAREVKKRAENDDSKSITSLATSTSRKSLQMKNCCNG", "length": 756 }, "evidence": [ { "id": "A0A3Q1M0B9", "url": "https://omabrowser.org/oma/group/A0A3Q1M0B9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IZ41-1", "protein_name": "Ras and EF-hand domain-containing protein", "gene_name": "RASEF", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEADGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCGPASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDPLQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDVPDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNCCNG", "length": 740 }, "evidence": [ { "id": "A0A3Q1M0B9", "url": "https://omabrowser.org/oma/group/A0A3Q1M0B9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ], "pmid": "" }, { "name": "GDP binding", "id": "GO:0019003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019003", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0B9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" }, { "start_pos": 375, "end_pos": 377, "annotation": "n_glycosylation_sequon" }, { "start_pos": 569, "end_pos": 571, "annotation": "n_glycosylation_sequon" }, { "start_pos": 722, "end_pos": 724, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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"uniprot_canonical_ac": "A0A3Q1M0D6-1", "uniprot_ac": "A0A3Q1M0D6", "uniprot_id": "A0A3Q1M0D6_BOVIN", "mass": { "chemical_mass": 297686.0, "monoisotopic_mass": 297686.0 }, "refseq": { "ac": "XP_002697976", "name": "serine/arginine repetitive matrix protein 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697976" }, "gene_names": [ { "name": "SRRM2", "type": "recommended", "evidence": [ { "id": "A0A3Q1M0D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0D6" } ] }, { "name": "SRRM2", "type": "synonym", "evidence": [ { "id": "XP_002697976", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697976" } ] } ], "protein_names": [ { "name": "Serine/arginine repetitive matrix 2", "type": "synonym", "evidence": [ { "id": "A0A3Q1M0D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0D6/entry#names_and_taxonomy" } ] }, { "name": "serine/arginine repetitive matrix protein 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002697976", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697976" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0D6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0D6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRRM2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0D6", "locus": { "chromosome": "25", "start_pos": 2284791, "end_pos": 2303506, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012683", "url": "https://www.ensembl.org/id/ENSBTAG00000012683" } ] } } ], "crossref": [ { "id": "ENSBTAG00000012683", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012683", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21375", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21375", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539515", "url": "https://www.ncbi.nlm.nih.gov/gene/539515", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024945", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024945", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539515", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539515", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M0D6", "url": "https://www.orthodb.org/?gene=A0A3Q1M0D6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MP73", "url": "https://www.orthodb.org/?gene=A0A3Q1MP73", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MI03", "url": "https://www.orthodb.org/?gene=F1MI03", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR34755", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34755", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34755:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34755:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36562", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36562", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR36562:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36562:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08312", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08312", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9770562", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002697976", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697976", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0D6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0D6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0D6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0D6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP73", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP73-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP73-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKX2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKX2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH17", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI03", "url": "https://www.uniprot.org/uniprotkb/F1MI03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI03-1", "url": "https://www.uniprot.org/uniprotkb/F1MI03-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEENPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALTGRSPSPALGRRGEGDVPPREPGTTNIGQPSSPEPSTKQPSSPCEDKDKKEKSAVRPSPSPERSNTGPEPPAPTLLLAEQHGGSPQPLATTPLSQEPVNPPSEASPAQGHSPPKSPEKPPQSSSESCPPSPQPTKVSRHASSSPESPKPAPAPGSRRESSSPASKSRSHGRAKRAKSHSHTPSRRVGRSRSPTTNKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNAQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPARRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRSGRSRSRTPNRRGRSQSRTPARRGRSHSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRLSSRRSRSLSSPRSKAKSRLSVRRSLSESSPCPKQKSQTPPRRSRSGSSQRKAKSRTPLRRSRSGSSPPGNQKSKTPSRQSHSSSSPQPKMKSGTPPRQGSVTSPQINEESATPQRGSRSESSPDPEVKSRTPSRHSCSGSSPSRVKSGTPPRRSRSGSSSPQPKVKAVTSPVQSHSGFSSPSPSRMTSKTPPRQSRSVSPCSKTESRLLQRHSHSRSSSPDTKVKPGTPPRQSHSGSTSPCPKAKPQTPPGHNLGSKSPCSQEKSKDSLAQSCSESFSLCPGVKSSTPPSFLQQKGQSPTSPDSRSGTSSPEMRPSHSESPYLQSKSQTPPKGSCSRSSSPVAELAPRSPTRGELSASPRLKSEISPEQSRSQSDSFSYPAIDSKSLLGQSRLEPSESKEKTGLLLQEDVSASPPRLRDKLSPPPVQNRPESSPILRDTPRTPSRERGGGVRLSPDTKDQSSALAKPSQDEELMEVVEKSEESSNQVLPHLSPERKETAGSNVESSPEIERPAVPLTLDQSQLQASSEEVPAMASAWSGPHFSPEHKELSNSPPRENSFGSPLEFRNSGGPVAEMNTGFSPEGKDLNGPFPNQLETDPSLDVKEQSTRSSRHSSSELSPDVVEKAGMSSNQSVSSPVLDAIPRTPSRERSSSASSPELKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVEQKTVARTPLGQRRRSGSSQELDGKPSASPQERSESDSSPDSKAKIRMPLRQRSHSGSSPEVDSKSRPSPRRSRSGSSPEVKEKPRAAPRAQSGSDSSPEPKAPAPRVLPRRSRSGSSSKGRGPSPEGSSSSESSPEHPPKSRTARRSSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRRRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRATRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLVSRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPIARRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTTRGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMGCFSRPSMSPTPLDRCRSPGVLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHPRASVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAASLASRIPAASAAAMNLASARTPALPSAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTAPTAANYPSSSRAPQAPAPANLVGPRSAHATAPVNIASSRTPPALAPANLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPGGPGSRTPPSAPSQSRVTSERALSPASRMVQAPSQSALPPAQDRPRSPVPSAFSDQSRSLLAQTTPVAGSQSLSSGTVAKTTSSAGDHNGMLSGPVPGVSHPEGGEPPACAGAQQPSTLAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPAQPEVALKRVPSPAPAPKEAVREGRPQEPAPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPAERRRPSPQPSPRDQQSSSERGSRRSQRGDSRSPGHKRRKETPSPRPVRHRSSRSP", "length": 2741, "header": "tr|A0A3Q1M0D6-1|A0A3Q1M0D6_BOVIN Isoform 1 of Serine/arginine repetitive matrix 2 OS=Bos taurus OX=9913 GN=SRRM2 PE=4 SV=1 CANONICAL=A0A3Q1M0D6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0D6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0D6/entry", "sequence": { "sequence": "MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEENPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALTGRSPSPALGRRGEGDVPPREPGTTNIGQPSSPEPSTKQPSSPCEDKDKKEKSAVRPSPSPERSNTGPEPPAPTLLLAEQHGGSPQPLATTPLSQEPVNPPSEASPAQGHSPPKSPEKPPQSSSESCPPSPQPTKVSRHASSSPESPKPAPAPGSRRESSSPASKSRSHGRAKRAKSHSHTPSRRVGRSRSPTTNKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNAQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPARRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRSGRSRSRTPNRRGRSQSRTPARRGRSHSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRLSSRRSRSLSSPRSKAKSRLSVRRSLSESSPCPKQKSQTPPRRSRSGSSQRKAKSRTPLRRSRSGSSPPGNQKSKTPSRQSHSSSSPQPKMKSGTPPRQGSVTSPQINEESATPQRGSRSESSPDPEVKSRTPSRHSCSGSSPSRVKSGTPPRRSRSGSSSPQPKVKAVTSPVQSHSGFSSPSPSRMTSKTPPRQSRSVSPCSKTESRLLQRHSHSRSSSPDTKVKPGTPPRQSHSGSTSPCPKAKPQTPPGHNLGSKSPCSQEKSKDSLAQSCSESFSLCPGVKSSTPPSFLQQKGQSPTSPDSRSGTSSPEMRPSHSESPYLQSKSQTPPKGSCSRSSSPVAELAPRSPTRGELSASPRLKSEISPEQSRSQSDSFSYPAIDSKSLLGQSRLEPSESKEKTGLLLQEDVSASPPRLRDKLSPPPVQNRPESSPILRDTPRTPSRERGGGVRLSPDTKDQSSALAKPSQDEELMEVVEKSEESSNQVLPHLSPERKETAGSNVESSPEIERPAVPLTLDQSQLQASSEEVPAMASAWSGPHFSPEHKELSNSPPRENSFGSPLEFRNSGGPVAEMNTGFSPEGKDLNGPFPNQLETDPSLDVKEQSTRSSRHSSSELSPDVVEKAGMSSNQSVSSPVLDAIPRTPSRERSSSASSPELKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVEQKTVARTPLGQRRRSGSSQELDGKPSASPQERSESDSSPDSKAKIRMPLRQRSHSGSSPEVDSKSRPSPRRSRSGSSPEVKEKPRAAPRAQSGSDSSPEPKAPAPRVLPRRSRSGSSSKGRGPSPEGSSSSESSPEHPPKSRTARRSSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRRRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRATRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLVSRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPIARRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTTRGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMGCFSRPSMSPTPLDRCRSPGVLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHPRASVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAASLASRIPAASAAAMNLASARTPALPSAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTAPTAANYPSSSRAPQAPAPANLVGPRSAHATAPVNIASSRTPPALAPANLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPGGPGSRTPPSAPSQSRVTSERALSPASRMVQAPSQSALPPAQDRPRSPVPSAFSDQSRSLLAQTTPVAGSQSLSSGTVAKTTSSAGDHNGMLSGPVPGVSHPEGGEPPACAGAQQPSTLAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPAQPEVALKRVPSPAPAPKEAVREGRPQEPAPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPAERRRPSPQPSPRDQQSSSERGSRRSQRGDSRSPGHKRRKETPSPRPVRHRSSRSP", "length": 2741, "header": "tr|A0A3Q1M0D6-1|A0A3Q1M0D6_BOVIN Isoform 1 of Serine/arginine repetitive matrix 2 OS=Bos taurus OX=9913 GN=SRRM2 PE=4 SV=1 CANONICAL=A0A3Q1M0D6-1" }, "locus": { "chromosome": "25", "start_pos": 2300163, "end_pos": 2285795, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071602.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071602.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066669.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066669.1" } ] } }, { "isoform_ac": "A0A3Q1MP73-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP73/entry", "sequence": { "sequence": "MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEENPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALTGRSPSPALGRRGEGDVPPREPGTTNIGQPSSPEPSTKQPSSPCEDKDKKEKSAVRPSPSPERSNTGPEPPAPTLLLAEQHGGSPQPLATTPLSQEPVNPPSEASPAQGHSPPKSPEKPPQSSSESCPPSPQPTKVSRHASSSPESPKPAPAPGSRRESSSPASKSRSHGRAKRAKSHSHTPSRRVGRSRSPTTNKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNAQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPARRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRSGRSRSRTPNRRGRSQSRTPARRGRSHSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRLSSRRSRSLSSPRSKAKSRLSVRRSLSESSPCPKQKSQTPPRRSRSGSSQRKAKSRTPLRRSRSGSSPPGNQKSKTPSRQSHSSSSPQPKMKSGTPPRQGSVTSPQINEESATPQRGSRSESSPDPEVKSRTPSRHSCSGSSPSRVKSGTPPRRSRSGSSSPQPKVKAVTSPVQSHSGFSSPSPSRMTSKTPPRQSRSVSPCSKTESRLLQRHSHSRSSSPDTKVKPGTPPRQSHSGSTSPCPKAKPQTPPGHNLGSKSPCSQEKSKDSLAQSCSESFSLCPGVKSSTPPSFLQQKGQSPTSPDSRSGTSSPEMRPSHSESPYLQSKSQTPPKGSCSRSSSPVAELAPRSPTRGELSASPRLKSEISPEQSRSQSDSFSYPAIDSKSLLGQSRLEPSESKEKTGLLLQEDVSASPPRLRDKLSPPPVQNRPESSPILRDTPRTPSRERGGGVRLSPDTKDQSSALAKPSQDEELMEVVEKSEESSNQVLPHLSPERKETAGSNVESSPEIERPAVPLTLDQSQLQASSEEVPAMASAWSGPHFSPEHKELSNSPPRENSFGSPLEFRNSGGPVAEMNTGFSPEGKDLNGPFPNQLETDPSLDVKEQSTRSSRHSSSELSPDVVEKAGMSSNQSVSSPVLDAIPRTPSRERSSSASSPELKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVEQKTVARTPLGQRRRSGSSQELDGKPSASPQERSESDSSPDSKAKIRMPLRQRSHSGSSPEVDSKSRPSPRRSRSGSSPEVKEKPRAAPRAQSGSDSSPEPKAPAPRVLPRRSRSGSSSKGRGPSPEGSSSSESSPEHPPKSRTARRSSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRRRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRATRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLVSRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPIARRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTTRGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMGCFSRPSMSPTPLDRCRSPGVLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHPRASVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAASLASRIPAASAAAMNLASARTPALPSAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTAPTAANYPSSSRAPQAPAPANLVGPRSAHATAPVNIASSRTPPALAPANLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPGGPGSRTPPSAPSQSRVTSERALSPASRMVQAPSQSALPPAQDRPRSPVPSAFSDQSRSLLAQTTPVAGSQSLSSGTVAKTTSSAGDHNGMLSGPVPGVSHPEGGEPPACAGAQQPSTLAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPAQPEVALKRVPSPAPAPKEAVREGRPQEPAPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSSSPSPAKPGPQALPKPASPKKPPPGERSLFPVSLPPRHSLPHVARGIFLKPHIWLLPSLHKSFRDALWPAG", "length": 2706, "header": "tr|A0A3Q1MP73-1|A0A3Q1M0D6_BOVIN Computationally mapped isoform of Serine/arginine repetitive matrix 2 OS=Bos taurus OX=9913 GN=SRRM2 PE=4 SV=2 CANONICAL=A0A3Q1M0D6-1" }, "locus": { "chromosome": "25", "start_pos": 2300163, "end_pos": 2286887, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075509.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075509.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071437.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071437.2" } ] } }, { "isoform_ac": "A0AAA9SKX2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKX2/entry", "sequence": { "sequence": "MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEENPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALTGRSPSPALGRRGEGDVPPREPGTTNIGQPSSPEPSTKQPSSPCEDKDKKEKSAVRPSPSPERSNTGPEPPAPTLLLAEQHGGSPQPLATTPLSQEPVNPPSEASPAQGHSPPKSPEKPPQSSSESCPPSPQPTKVSRHASSSPESPKPAPAPGSRRESSSPASKSRSHGRAKRAKSHSHTPSRRVGRSRSPTTNKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNAQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPARRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRSGRSRSRTPNRRGRSQSRTPARRGRSHSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRLSSRRSRSLSSPRSKAKSRLSVRRSLSESSPCPKQKSQTPPRRSRSGSSQRKAKSRTPLRRSRSGSSPPGNQKSKTPSRQSHSSSSPQPKMKSGTPPRQGSVTSPQINEESATPQRGSRSESSPDPEVKSRTPSRHSCSGSSPSRVKSGTPPRRSRSGSSSPQPKVKAVTSPVQSHSGFSSPSPSRMTSKTPPRQSRSVSPCSKTESRLLQRHSHSRSSSPDTKVKPGTPPRQSHSGSTSPCPKAKPQTPPGHNLGSKSPCSQEKSKDSLAQSCSESFSLCPGVKSSTPPSFLQQKGQSPTSPDSRSGTSSPEMRPSHSESPYLQSKSQTPPKGSCSRSSSPVAELAPRSPTRGELSASPRLKSEISPEQSRSQSDSFSYPAIDSKSLLGQSRLEPSESKEKTGLLLQEDVSASPPRLRDKLSPPPVQNRPESSPILRDTPRTPSRERGGGVRLSPDTKDQSSALAKPSQDEELMEVVEKSEESSNQVLPHLSPERKETAGSNVESSPEIERPAVPLTLDQSQLQASSEEVPAMASAWSGPHFSPEHKELSNSPPRENSFGSPLEFRNSGGPVAEMNTGFSPEGKDLNGPFPNQLETDPSLDVKEQSTRSSRHSSSELSPDVVEKAGMSSNQSVSSPVLDAIPRTPSRERSSSASSPELKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVEQKTVARTPLGQRRRSGSSQELDGKPSASPQERSESDSSPDSKAKIRMPLRQRSHSGSSPEVDSKSRPSPRRSRSGSSPEVKEKPRAAPRAQSGSDSSPEPKAPAPRVLPRRSRSGSSSKGRGPSPEGSSSSESSPEHPPKSRTARRSSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRRRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRATRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLVSRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPIARRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTTRGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMGCFSRPSMSPTPLDRCRSPGVLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHPRASVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAASLASRIPAASAAAMNLASARTPALPSAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTAPTAANYPSSSRAPQAPAPANLVGPRSAHATAPVNIASSRTPPALAPANLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPGGPGSRTPPSAPSQSRVTSERALSPASRMVQAPSQSALPPAQDRPRSPVPSAFSDQSRSLLAQTTPVAGSQSLSSGTVAKTTSSAGDHNGMLSGPVPGVSHPEGGEPPACAGAQQPSTLAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPAQPEVALKRGQN", "length": 2571, "header": "tr|A0AAA9SKX2-1|A0A3Q1M0D6_BOVIN Computationally mapped isoform of Serine/arginine repetitive matrix 2 OS=Bos taurus OX=9913 GN=SRRM2 PE=4 SV=1 CANONICAL=A0A3Q1M0D6-1" }, "locus": { "chromosome": "25", "start_pos": 2300163, "end_pos": 2288098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097308.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097308.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084557.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084557.1" } ] } }, { "isoform_ac": "A0AAA9TH17-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH17/entry", "sequence": { "sequence": "MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEENPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALTGRSPSPALGRRGEGDVPPREPGTTNIGQPSSPEPSTKQPSSPCEDKDKKEKSAVRPSPSPERSNTGPEPPAPTLLLAEQHGGSPQPLATTPLSQEPVNPPSEASPAQGHSPPKSPEKPPQSSSESCPPSPQPTKVSRHASSSPESPKPAPAPGSRRESSSPASKSRSHGRAKRAKSHSHTPSRRVGRSRSPTTNKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNAQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPARRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRSGRSRSRTPNRRGRSQSRTPARRGRSHSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRLSSRRSRSLSSPRSKAKSRLSVRRSLSESSPCPKQKSQTPPRRSRSGSSQRKAKSRTPLRRSRSGSSPPGNQKSKTPSRQSHSSSSPQPKMKSGTPPRQGSVTSPQINEESATPQRGSRSESSPDPEVKSRTPSRHSCSGSSPSRVKSGTPPRRSRSGSSSPQPKVKAVTSPVQSHSGFSSPSPSRMTSKTPPRQSRSVSPCSKTESRLLQRHSHSRSSSPDTKVKPGTPPRQSHSGSTSPCPKAKPQTPPGHNLGSKSPCSQEKSKDSLAQSCSESFSLCPGVKSSTPPSFLQQKGQSPTSPDSRSGTSSPEMRPSHSESPYLQSKSQTPPKGSCSRSSSPVAELAPRSPTRGELSASPRLKSEISPEQSRSQSDSFSYPAIDSKSLLGQSRLEPSESKEKTGLLLQEDVSASPPRLRDKLSPPPVQNRPESSPILRDTPRTPSRERGGGVRLSPDTKDQSSALAKPSQDEELMEVVEKSEESSNQVLPHLSPERKETAGSNVESSPEIERPAVPLTLDQSQLQASSEEVPAMASAWSGPHFSPEHKELSNSPPRENSFGSPLEFRNSGGPVAEMNTGFSPEGKDLNGPFPNQLETDPSLDVKEQSTRSSRHSSSELSPDVVEKAGMSSNQSVSSPVLDAIPRTPSRERSSSASSPELKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVEQKTVARTPLGQRRRSGSSQELDGKPSASPQERSESDSSPDSKAKIRMPLRQRSHSGSSPEVDSKSRPSPRRSRSGSSPEVKEKPRAAPRAQSGSDSSPEPKAPAPRVLPRRSRSGSSSKGRGPSPEGSSSSESSPEHPPKSRTARRSSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRRRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRATRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLVSRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPIARRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTTRGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMGCFSRPSMSPTPLDRCRSPGVLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHPRASVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAASLASRIPAASAAAMNLASARTPALPSAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTAPTAANYPSSSRAPQAPAPANLVGPRSAHATAPVNIASSRTPPALAPANLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPGGPGSRTPPSAPSQSRVTSERALSPASRMVQAPSQSALPPAQDRPRSPVPSAFSDQSRSLLAQTTPVAGSQSLSSGTVAKTTSSAGDHNGMLSGPVPGVSHPEGGEPPACAGAQQPSTLAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPAQPEVALKRVPSPAPAPKEAVREGRPQEPAPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSSSPSPAKPGPQALPKPASPKKPPPGERSHTQQRLAV", "length": 2672, "header": "tr|A0AAA9TH17-1|A0A3Q1M0D6_BOVIN Computationally mapped isoform of Serine/arginine repetitive matrix 2 OS=Bos taurus OX=9913 GN=SRRM2 PE=4 SV=1 CANONICAL=A0A3Q1M0D6-1" }, "locus": { "chromosome": "25", "start_pos": 2300163, "end_pos": 2286755, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119583.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119583.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096342.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096342.1" } ] } }, { "isoform_ac": "F1MI03-1", "url": "https://www.uniprot.org/uniprotkb/F1MI03/entry", "sequence": { "sequence": "MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEENPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALTGRSPSPALGRRGEGDVPPREPGTTNIGQPSSPEPSTKQPSSPCEDKDKKEKSAVRPSPSPERSNTGPEPPAPTLLLAEQHGGSPQPLATTPLSQEPVNPPSEASPAQGHSPPKSPEKPPQSSSESCPPSPQPTKVSRHASSSPESPKPAPAPGSRRESSSPASKSRSHGRAKRAKSHSHTPSRRVGRSRSPTTNKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNAQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPARRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRSGRSRSRTPNRRGRSQSRTPARRGRSHSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRLSSRRSRSLSSPRSKAKSRLSVRRSLSESSPCPKQKSQTPPRRSRSGSSQRKAKSRTPLRRSRSGSSPPGNQKSKTPSRQSHSSSSPQPKMKSGTPPRQGSVTSPQINEESATPQRGSRSESSPDPEVKSRTPSRHSCSGSSPSRVKSGTPPRRSRSGSSSPQPKVKAVTSPVQSHSGFSSPSPSRMTSKTPPRQSRSVSPCSKTESRLLQRHSHSRSSSPDTKVKPGTPPRQSHSGSTSPCPKAKPQTPPGHNLGSKSPCSQEKSKDSLAQSCSESFSLCPGVKSSTPPSFLQQKGQSPTSPDSRSGTSSPEMRPSHSESPYLQSKSQTPPKGSCSRSSSPVAELAPRSPTRGELSASPRLKSEISPEQSRSQSDSFSYPAIDSKSLLGQSRLEPSESKEKTGLLLQEDVSASPPRLRDKLSPPPVQNRPESSPILRDTPRTPSRERGGGVRLSPDTKDQSSALAKPSQDEELMEVVEKSEESSNQVLPHLSPERKETAGSNVESSPEIERPAVPLTLDQSQLQASSEEVPAMASAWSGPHFSPEHKELSNSPPRENSFGSPLEFRNSGGPVAEMNTGFSPEGKDLNGPFPNQLETDPSLDVKEQSTRSSRHSSSELSPDVVEKAGMSSNQSVSSPVLDAIPRTPSRERSSSASSPELKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVEQKTVARTPLGQRRRSGSSQELDGKPSASPQERSESDSSPDSKAKIRMPLRQRSHSGSSPEVDSKSRPSPRRSRSGSSPEVKEKPRAAPRAQSGSDSSPEPKAPAPRVLPRRSRSGSSSKGRGPSPEGSSSSESSPEHPPKSRTARRSSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRRRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRATRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLVSRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPIARRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTTRGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMGCFSRPSMSPTPLDRCRSPGVLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHPRASVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAASLASRIPAASAAAMNLASARTPALPSAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTAPTAANYPSSSRAPQAPAPANLVGPRSAHATAPVNIASSRTPPALAPANLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPGGPGSRTPPSAPSQSRVTSERALSPASRMVQAPSQSALPPAQDRPRSPVPSAFSDQSRSLLAQTTPVAGSQSLSSGTVAKTTSSAGDHNGMLSGPVPGVSHPEGGEPPACAGAQQPSTLAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPAQPEVALKRVPSPAPAPKEAVREGRPQEPAPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSSSPSPAKPGPQALPKPASPKKPPPGERSSERGSRRSQRGDSRSPGHKRRKETPSPRPVRHRSSRSP", "length": 2702, "header": "tr|F1MI03-1|A0A3Q1M0D6_BOVIN Computationally mapped isoform of Serine/arginine repetitive matrix 2 OS=Bos taurus OX=9913 GN=SRRM2 PE=4 SV=3 CANONICAL=A0A3Q1M0D6-1" }, "locus": { "chromosome": "25", "start_pos": 2300163, "end_pos": 2285795, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037527.6", "url": "https://www.ensembl.org/id/ENSBTAT00000037527.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037356.6", "url": "https://www.ensembl.org/id/ENSBTAP00000037356.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2301, "start_aa": "Thr", "end_pos": 2301, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2301", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539515", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539515", "resource": "KEGG Pathway" }, { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" }, { "id": "R-BTA-9770562", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "resource": "Reactome", "description": "mRNA Polyadenylation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0D6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0D6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0D6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0D6" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0D6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0D6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0D6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0D6" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": 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"categories": [ "Protein" ] }, { "id": "E1BGW4-1", "url": "https://www.uniprot.org/uniprotkb/E1BGW4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPIVDKLKEALKPGRRDSADDGDLGKLLAASAKKVLLQKLEFEPASKSFSYQLESLKSKYVLLNPRTEGARCHRSGDEPPARRQGSEHAYESCSDGVPAPQKVLFPVERLSLRWGRVYRVGAGLHNLGNTCFLNSTVQCLTYTPPLANYLLSKEHTRGCHQGSFCMLCVMQNHIIQAFANSGNAIKPVSFIRDLRKIARHFRFGNQEDAHEFLRYTIDAMQKACLSGCAKLDRQTQATTLVHQIFGGYLRSRVKCSMCKSVSDTYDPYLDVALEIRQAANIVRALELFVKPDVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQSSGEPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHASNIKVVLNQQAYVLFYLRIPGSKKSPEGSISRTASLSSRPGVVPDHVRKNVSNGTAASPMTGKRPDPVTMKKPQTPEELGVPIARNGSVLGLKSPNGYAPAKPPLASPSPKVCRTPTHAPAILDEPGKKVKKPASLQHFSPPPSASAPGGSRSEGRRPGSWDGRAAVSTSLRAPAAGTPNGLGPQAGDEGPTPERGGSSPEHPTSRPPQAPQSGVTPLGDSQGTHSVTAGPTKVLPARQDAEPEKAKCPVPSSTSPEPANTMSPPPAKKLALSAKKASTLRRATGNDLRPPALSPSSDLTYPRKPTHPIVAAPWPVRAIRAVSPAPRPSSHLKPPFGPCPPSLSSSPHPLGTSDPQSCSPTSAPLPQVNGAFRAPLHQLPEASEPLRSLGKKRKKTRVKVGGRVSETCTAVAAQPGKRRKRKRKHMGDVDATPLQDERTPGPPWSPERRKEGRAEPPADRSEEEGRQQPGSGQRLENSWPVGCMTNGPHVSSRKRRRKGLESCDEEDCLPGDPPWHGSCVPSDVVQPETVATSPRKKKKKKKKQEPRQEVEEKEPEGQRGPAVPGCSPLPAVNGQAPRGPTGLGPAPLASWDRERESDVVQELLKYSSDKAYGRKVLTWDGAVSAVSQDAIQDSRLARTATVIDDWDEEFDRGKPPEARHPSPRTVCLDRRAACRGLAGLLVGERPQRPWASAQVNTTCTVTDRVVTHGAGAAQRRGRGVGPAPCDAGRQRPAWSRRG", "length": 1142, "header": "tr|A0A3Q1M0E6-1|A0A3Q1M0E6_BOVIN Isoform 1 of ubiquitinyl hydrolase 1 OS=Bos taurus OX=9913 GN=USP36 PE=3 SV=2 CANONICAL=A0A3Q1M0E6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0E6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6/entry", "sequence": { "sequence": "MPIVDKLKEALKPGRRDSADDGDLGKLLAASAKKVLLQKLEFEPASKSFSYQLESLKSKYVLLNPRTEGARCHRSGDEPPARRQGSEHAYESCSDGVPAPQKVLFPVERLSLRWGRVYRVGAGLHNLGNTCFLNSTVQCLTYTPPLANYLLSKEHTRGCHQGSFCMLCVMQNHIIQAFANSGNAIKPVSFIRDLRKIARHFRFGNQEDAHEFLRYTIDAMQKACLSGCAKLDRQTQATTLVHQIFGGYLRSRVKCSMCKSVSDTYDPYLDVALEIRQAANIVRALELFVKPDVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQSSGEPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHASNIKVVLNQQAYVLFYLRIPGSKKSPEGSISRTASLSSRPGVVPDHVRKNVSNGTAASPMTGKRPDPVTMKKPQTPEELGVPIARNGSVLGLKSPNGYAPAKPPLASPSPKVCRTPTHAPAILDEPGKKVKKPASLQHFSPPPSASAPGGSRSEGRRPGSWDGRAAVSTSLRAPAAGTPNGLGPQAGDEGPTPERGGSSPEHPTSRPPQAPQSGVTPLGDSQGTHSVTAGPTKVLPARQDAEPEKAKCPVPSSTSPEPANTMSPPPAKKLALSAKKASTLRRATGNDLRPPALSPSSDLTYPRKPTHPIVAAPWPVRAIRAVSPAPRPSSHLKPPFGPCPPSLSSSPHPLGTSDPQSCSPTSAPLPQVNGAFRAPLHQLPEASEPLRSLGKKRKKTRVKVGGRVSETCTAVAAQPGKRRKRKRKHMGDVDATPLQDERTPGPPWSPERRKEGRAEPPADRSEEEGRQQPGSGQRLENSWPVGCMTNGPHVSSRKRRRKGLESCDEEDCLPGDPPWHGSCVPSDVVQPETVATSPRKKKKKKKKQEPRQEVEEKEPEGQRGPAVPGCSPLPAVNGQAPRGPTGLGPAPLASWDRERESDVVQELLKYSSDKAYGRKVLTWDGAVSAVSQDAIQDSRLARTATVIDDWDEEFDRGKPPEARHPSPRTVCLDRRAACRGLAGLLVGERPQRPWASAQVNTTCTVTDRVVTHGAGAAQRRGRGVGPAPCDAGRQRPAWSRRG", "length": 1142, "header": "tr|A0A3Q1M0E6-1|A0A3Q1M0E6_BOVIN Isoform 1 of ubiquitinyl hydrolase 1 OS=Bos taurus OX=9913 GN=USP36 PE=3 SV=2 CANONICAL=A0A3Q1M0E6-1" }, "locus": { "chromosome": "19", "start_pos": 53553308, "end_pos": 53528773, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087341.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087341.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066681.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066681.2" } ] } }, { "isoform_ac": "E1BGW4-1", "url": "https://www.uniprot.org/uniprotkb/E1BGW4/entry", "sequence": { "sequence": "MPIVDKLKEALKPGRRDSADDGDLGKLLAASAKKVLLQKLEFEPASKSFSYQLESLKSKYVLLNPRTEGARCHRSGDEPPARRQGSEHAYESCSDGVPAPQKVLFPVERLSLRWGRVYRVGAGLHNLGNTCFLNSTVQCLTYTPPLANYLLSKEHTRGCHQGSFCMLCVMQNHIIQAFANSGNAIKPVSFIRDLRKIARHFRFGNQEDAHEFLRYTIDAMQKACLSGCAKLDRQTQATTLVHQIFGGYLRSRVKCSMCKSVSDTYDPYLDVALEIRQAANIVRALELFVKPDVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQSSGEPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHASNIKVVLNQQAYVLFYLRIPGSKKSPEGSISRTASLSSRPGVVPDHVRKNVSNGTAASPMTGKRPDPVTMKKPQTPEELGVPIARNGSVLGLKSPNGYAPAKPPLASPSPKVCRTPTHAPAILDEPGKKVKKPASLQHFSPPPSASAPGGSRSEGRRPGSWDGRAAVSTSLRAPAAGTPNGLGPQAGDEGPTPERGGSSPEHPTSRPPQAPQSGVTPLGDSQGTHSVTAGPTKVLPARQDAEPEKAKCPVPSSTSPEPANTMSPPPAKKLALSAKKASTLRRATGNDLRPPALSPSSDLTYPRKPTHPIVAAPWPVRAIRAVSPAPRPSSHLKPPFGPCPPSLSSSPHPLGTSDPQSCSPTSAPLPQVNGAFRAPLHQLPEASEPLRSLGKKRKKTRVKVGGRVSETCTAVAAQPGKRRKRKRKHMGDVDATPLQDERTPGPPWSPERRKEGRAEPPADRSEEEGRQQPGSGQRLENSWPVGCMTNGPHVSSRKRRRKGLESCDEEDCLPGDPPWHGSCVPSDVVQPETVATSPRKKKKKKKKQEPRQEVEEKEPEGQRGPAVPGCSPLPAVNGQAPRGPTGLGPAPLASWDRERESDVVQELLKYSSDKAYGRKVLTWDGAVSAVSQDAIQDSRLARTATVIDDWDEEFDRGKEKKLKKFKREKKRNFNAFQKLQSRRNFWSVTHPAKASSLSYRR", "length": 1101, "header": "tr|E1BGW4-1|A0A3Q1M0E6_BOVIN Computationally mapped isoform of ubiquitinyl hydrolase 1 OS=Bos taurus OX=9913 GN=USP36 PE=3 SV=2 CANONICAL=A0A3Q1M0E6-1" }, "locus": { "chromosome": "19", "start_pos": 53552827, "end_pos": 53528773, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028663.8", "url": "https://www.ensembl.org/id/ENSBTAT00000028663.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028663.5", "url": "https://www.ensembl.org/id/ENSBTAP00000028663.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 596, "start_aa": "Thr", "end_pos": 596, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr596", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:504581", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504581", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K033-1", "protein_name": "ubiquitinyl hydrolase 1", "gene_name": "Usp36", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPIVDKLKEALKPGRKDSAEDGDLGKLLAASAKKVLLQRIEFEPASKSFSYQLESLKSKYVLLNPKAEGAGRHRSGDEPQARKPGTERMSGSGGDGVPAPQKVLFPVERLSLRWERVFRVGAGLHNLGNTCFLNSTIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHMVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGYAKLDRQTQATTLVHQIFGGYLRSRVKCSVCRSVSDTYDPYLDIALEIRQAANIVRALELFVKSDVLSGENAYMCAKCKKKVPASKRFSIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQSSGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLSQQAYVLFYLRIPGSKKSPEGPVSRVGATLPSRPKVIPEHPKKSPGNGVVSSPLMAKRQDSLMMRKLQSPEEVGMPVSRNGSISGLKLQNGCAPAKSPAGSPSPRLAPTPTHMPTILDEPGEKVKKSAPPQSRTTSPTASQGFPGTGESRSQRPGSWASRDSIFSTSPKLAKAITNGHRLKGEGNGVDLEKGDSSSSSPEHSASSDAAKAPQTSEGRAAHVCDSQGTNCPATGHSKVLSNGVDAKMGKLKSPALSSTTTEPTSLMSPPPAKKLALSAKKASTLRRATGNDIGSPSPSAFCDLTSPMKATHPVVASPGPVSKTRAAAAPAPQPSPHPHSASLSSSSAKPLGTSEPQSCCSSAWTPLPQVNGHFTSHLHQLPEANEALHSPSRKRKKTPSGDPQRLGRDTHLPQCLEGAPATARRKKRKKKKDLEGVGDTATQQESQSQDQPWSPRGRKEEGTQLQVNGHQVSHILDSYHASSRKRRKRKRSEGLSQEATVCQDLLQHGCSPADHCEPEARTELQKKKKRRKRKPEPQQEEESEHPGYQRSPRPSVTPVPELCVNDHLPSDRLGLGRAPLVTWNRDQEPDVVQELLQDSSDTAYGKKVLTWDGEPSAISQDAMKDSRLARTQTVVDDWDEEFDRGKEKKIKKFKREKKRNFNAFQKLQSRRNFWSVTHPAKVASLSYRR", "length": 1098 }, "evidence": [ { "id": "A0A3Q1M0E6", "url": "https://omabrowser.org/oma/group/A0A3Q1M0E6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B1AQJ2-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 36", "gene_name": "Usp36", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPIVDKLKEALKPGRKDSAEDGDLGRLLAASAKKVLLQRIEFEPASKSFSYQLESLKSKYVLLSARAEGASRHRSGDELQARKPGTERVSGSGGDGVPAPQKVLFPVERLSLRWERVFRVGAGLHNLGNTCFLNSTIQCLTYTPPLANYLLSKEHARSCHQGGFCMLCLMQNHMVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGYAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDIALEIRQAANIVRALELFVKSDVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQSSGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGPVSRVGATLPSRPKVVPEHSKKSPGNGVVPSPLMAKRQDSVMMRKLPAPEEVGVPVSRNGSLPGLKLQNGCAPAKTPAGSPSPRLTPTPTHMPTILDEPGKKVKKSAPLQSLTTSPTTSQGSPGTGESRSQRPGSWASRDTIFSTSPKLLARAITNGHRLKGEGSGVDLEKGDSSSSSPEHSASSDPAKAPQTAESRAAHACDSQGTNCPTAGHPKALLNGVDAKMVKLKSPALSSTTTEPTSLMSPPPAKKLALSAKKASTLRRATGNDIGSPSPSAFCDLTSPMKATHPVVASTGPVSKTRTAAPAPRPSTHPHSASLSSSSAKPLGTSEPQSCRPSAWTPLPQVNGHFTSHLHQLPEASEALHSPSKKRKKTPNGDPQRLGIDTLLPQCLRGAPAAARRKRKKRCSEGEGATAPKQEGQFQDQSWSSGSQKEEGTQPQVNGHQVSHILDSYHVSSRKRRKRKRSEGLSQEATPSQDLIQHSCSPVDHSEPEARTELQKKKKKKRRKRKPEPQQDEESKHPGDQRSPRPSVTPVPALSVNGHLPSDCLGLGQAPLVTWNRDQEPDVVQALLQDSSDKAYGKKVLTWDGEPSAISQDAIKDSRLARTQTVVDDWDEEFDRGKEKKIKKFKREKKRNFNAFQKLQSRRNFWSVTHPAKVASLSYRR", "length": 1098 }, "evidence": [ { "id": "A0A3Q1M0E6", "url": "https://omabrowser.org/oma/group/A0A3Q1M0E6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P275-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 36", "gene_name": "USP36", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPIVDKLKEALKPGRKDSADDGELGKLLASSAKKVLLQKIEFEPASKSFSYQLEALKSKYVLLNPKTEGASRHKSGDDPPARRQGSEHTYESCGDGVPAPQKVLFPTERLSLRWERVFRVGAGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIPDHSKKNIGNGIISSPLTGKRQDSGTMKKPHTTEEIGVPISRNGSTLGLKSQNGCIPPKLPSGSPSPKLSQTPTHMPTILDDPGKKVKKPAPPQHFSPRTAQGLPGTSNSNSSRSGSQRQGSWDSRDVVLSTSPKLLATATANGHGLKGNDESAGLDRRGSSSSSPEHSASSDSTKAPQTPRSGAAHLCDSQETNCSTAGHSKTPPSGADSKTVKLKSPVLSNTTTEPASTMSPPPAKKLALSAKKASTLWRATGNDLRPPPPSPSSDLTHPMKTSHPVVASTWPVHRARAVSPAPQSSSRLQPPFSPHPTLLSSTPKPPGTSEPRSCSSISTALPQVNEDLVSLPHQLPEASEPPQSPSEKRKKTFVGEPQRLGSETRLPQHIREATAAPHGKRKRKKKKRPEDTAASALQEGQTQRQPGSPMYRREGQAQLPAVRRQEDGTQPQVNGQQVGCVTDGHHASSRKRRRKGAEGLGEEGGLHQDPLRHSCSPMGDGDPEAMEESPRKKKKKKRKQETQRAVEEDGHLKCPRSAKPQDAVVPESSSCAPSANGWCPGDRMGLSQAPPVSWNGERESDVVQELLKYSSDKAYGRKVLTWDGKMSAVSQDAIEDSRQARTETVVDDWDEEFDRGKEKKIKKFKREKRRNFNAFQKLQTRRNFWSVTHPAKAASLSYRR", "length": 1123 }, "evidence": [ { "id": "A0A3Q1M0E6", "url": "https://omabrowser.org/oma/group/A0A3Q1M0E6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "nucleolus organization", "id": "GO:0007000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007000", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" }, { "name": "regulation of rRNA processing", "id": "GO:2000232", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000232", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" }, { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" }, { "name": "protein deubiquitination", "id": "GO:0016579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016579", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" }, { "name": "negative regulation of macroautophagy", "id": "GO:0016242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016242", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" }, { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" }, { "name": "K48-linked deubiquitinase activity", "id": "GO:1990380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990380", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" }, { "name": "histone H2B deubiquitinase activity", "id": "GO:0140936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140936", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0E6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1100, "end_pos": 1102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 333, "end_pos": 335, "annotation": "n_glycosylation_sequon" }, { "start_pos": 398, "end_pos": 400, "annotation": "n_glycosylation_sequon" }, { "start_pos": 454, "end_pos": 456, "annotation": "n_glycosylation_sequon" }, { "start_pos": 457, "end_pos": 459, "annotation": "n_glycosylation_sequon" }, { "start_pos": 490, "end_pos": 492, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M0E6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1142, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M0E6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0E6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M0E6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0E6" }, { "id": "PS50235", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50235" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "USP", "eco_id": "ECO_0000259", "start_pos": 122, "end_pos": 423, "start_aa": "Ala", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.19.12", "ec_name": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "3.4.19.12", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.19.12" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 596 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1100, "end_pos": 1102 }, { "start_pos": 134, "end_pos": 136 }, { "start_pos": 333, "end_pos": 335 }, { "start_pos": 398, "end_pos": 400 }, { "start_pos": 454, "end_pos": 456 }, { "start_pos": 457, "end_pos": 459 }, { "start_pos": 490, "end_pos": 492 } ] }, "class_list": [], "section_stats": [ { "table_id": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"length": 1019, "header": "tr|F1MTV2-1|A0A3Q1M0F8_BOVIN Computationally mapped isoform of Zinc finger protein 654 OS=Bos taurus OX=9913 GN=ZNF654 PE=3 SV=4 CANONICAL=A0A3Q1M0F8-1" }, "locus": { "chromosome": "1", "start_pos": 36147143, "end_pos": 36091709, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032410.7", "url": "https://www.ensembl.org/id/ENSBTAT00000032410.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032342.6", "url": "https://www.ensembl.org/id/ENSBTAP00000032342.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100335242", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100335242", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", 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"https://www.ebi.ac.uk/QuickGO/term/GO:0042056", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0J5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0J5" } ], "pmid": "" }, { "name": "CCR6 chemokine receptor binding", "id": "GO:0031731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031731", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0J5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0J5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell chemotaxis", "id": "GO:0060326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060326", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0J5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0J5" } ], "pmid": "" }, { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0J5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0J5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 21, "end_pos": 23, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M0J5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 67, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M0J5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0J5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M0J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0J5" }, { "id": "PF00711", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00711" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Beta-defensin-like", "eco_id": "ECO_0000259", "start_pos": 29, "end_pos": 64, "start_aa": "Gln", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 21, "end_pos": 23 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M0L5-1", "uniprot_ac": "A0A3Q1M0L5", "uniprot_id": "A0A3Q1M0L5_BOVIN", "mass": { "chemical_mass": 157474.0, "monoisotopic_mass": 157474.0 }, "refseq": { "ac": "XP_024855422", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 13", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855422" }, "gene_names": [ { "name": "ADAMTS13", "type": "recommended", "evidence": [ { "id": "A0A3Q1M0L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5" } ] }, { "name": "ADAMTS13", "type": "synonym", "evidence": [ { "id": "XP_024855422", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855422" } ] } ], "protein_names": [ { "name": "A disintegrin and metalloproteinase with thrombospondin motifs 13", "type": "recommended", "evidence": [ { "id": "A0A3Q1M0L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5/entry#names_and_taxonomy" } ] }, { "name": "3.4.24.87", "type": "synonym", "evidence": [ { "id": "A0A3Q1M0L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5/entry#names_and_taxonomy" } ] }, { "name": "A disintegrin and metalloproteinase with thrombospondin motifs 13", "type": "synonym", "evidence": [ { "id": "XP_024855422", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855422" } ] }, { "name": "von Willebrand factor-cleaving protease", "type": "synonym", "evidence": [ { "id": "A0A3Q1M0L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.", "evidence": [ { "database": "UniProtKB", "id": "A0ABI0NJS8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJS8#function" }, { "database": "UniProtKB", "id": "ARBA00058288", "url": "https://www.uniprot.org/uniprotkb/ARBA00058288#function" }, { "database": "UniProtKB", "id": "A0A3Q1M0L5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0L5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADAMTS13", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5", "locus": { "chromosome": "11", "start_pos": 104351750, "end_pos": 104317447, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015093", "url": "https://www.ensembl.org/id/ENSBTAG00000015093" } ] } } ], "crossref": [ { "id": "A0A3Q1M0L5", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0L5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015093", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015093", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000051781", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051781", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04273", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04273", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532272", "url": "https://www.ncbi.nlm.nih.gov/gene/532272", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006586", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006586", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010294", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532272", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532272", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MVP0", "url": "https://www.orthodb.org/?gene=F1MVP0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13723", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13723", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13723:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13723:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00090", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00090", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01421", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01421", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05986", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05986", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17771", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17771", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19030", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19030", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19236", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19236", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5173214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9769739", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769739", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024855422", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855422", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0L5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0L5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NJS8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NJS8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJS8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVP0", "url": "https://www.uniprot.org/uniprotkb/F1MVP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MVP0-1", "url": "https://www.uniprot.org/uniprotkb/F1MVP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPSAQGRGVRGTLTSALFFLSCWALPDPRQQFLQVLEPADVTSYFGPDAAFEGPRLSALPAPSPGRPLAPRLRRRAAGHVLHLELLVAVGPDVHRTHGEETERYVLTNLNMGSELLRDPSLGAQFRVHLVKMVILTQPEDAPEITANITASLLSVCEWSRTVNPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSSSWSCLITEDTGFDLGLTIAHEIGHSFGLEHDGVPGSGCGPSGHVMASDGAAPALALGGPAWSPCSRRQLLSLLSAGRARCLWDPPGPLSGPAGQPPEVQPGLYYGADEQCRVAFGPTAVACTFRGEHLDMCQALSCHTDPLDPSSCSRLLIPLLDGTECGVGKWCSKGHCRSLAELAPVGVVHGHWSGWGPASPCSRSCGGGVITRRRRCNNPRPAFGGRTCVGSDLQAEMCNTQACEKTQLEFMSEQCAQTDSEPLRLSPGGSTAFYRWGTAEQYSEGNALCRHVCRAVGESFMVRRGDRFLDGTRCVPGDPQEDGALRLCVSGSCRTFGCDGRMDSGQVRDVCQVCGGDNSTCQPQSGSFTAGRAREYVTFLTVTPNLTSIYIINRRPLFTHLAVRVRGRYVVAGNGSASASTSYPSLLEDNRVEYRVTLSEDRLPRREEIRIRGPTRDDMEIQVYRRYSEEYGSPARPDITFIYFQPEQRRAWAWVPVQGPCSVSCGAGLRQVTYRCRDQSRSEWVEAAHCAGSQPPVAWSETCTPGPCPPHWEAGDFGPCSASCGGGLREREVRCVEARGGLLRTVPRSRCRALAPQPAAVDTCNSQPCPQRETDACSSACGADPAVQNTTCVPGSDGTGLLVTAGPCSADEKPPAPEPCVEATCPPGWDQLDVRPPGREAASPAGGPGLEALAAHVWTPLAGPCSVSCGQGLVELRFVCMDTALRTPVREELCDLASKPGSRREACQAAPCPARWETRALAPCPVTCGGGQVPLAVRCVRMDQGRLVSLPHSKCWPMPRPRTLEDCSLEPCPARWRYKLAACSLSCGGGVAQRILYCARAHGEDTDEEILPDTQCQGLPRPEQQEACSPEPCPPRWKVTSLGPCSASCGLGTATRSLACVRLDHGQDTEVDGAACAGLVQPQASIPCIVADCAYRWHVSAWTQCSVSCGEGIQHRHDACLGPGAQVPVPADFCQHLPKPVTVRGCQAGPCVGQGMASPAPREEATAPGQTTAATAASLEWPQPHTRLLSPAQGRLPGPQESPVETSVCGRQHLGPTGIIDMRGTARPDCAVAIGRPLGEVVTLRFLEGSLNCSAGEMLLLWGRLVWRKMCGKPAGMVFSSQANTLLVRQRLVRPGGGVLLRYSSQPALGAFHRGCDMQLFGPRGEISSPSMSPDGRNVGGCRIFIDVAPWARIAIHALTVDSGTRAEGTDASYILIRDIHSLRTTAFRGQKTLYWESEGSQAEMEFSQGFLEAHASLRGQYWTLHTRAG", "length": 1470, "header": "tr|A0A3Q1M0L5-1|A0A3Q1M0L5_BOVIN Isoform 1 of A disintegrin and metalloproteinase with thrombospondin motifs 13 OS=Bos taurus OX=9913 GN=ADAMTS13 PE=4 SV=2 CANONICAL=A0A3Q1M0L5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0L5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5/entry", "sequence": { "sequence": "MAPSAQGRGVRGTLTSALFFLSCWALPDPRQQFLQVLEPADVTSYFGPDAAFEGPRLSALPAPSPGRPLAPRLRRRAAGHVLHLELLVAVGPDVHRTHGEETERYVLTNLNMGSELLRDPSLGAQFRVHLVKMVILTQPEDAPEITANITASLLSVCEWSRTVNPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSSSWSCLITEDTGFDLGLTIAHEIGHSFGLEHDGVPGSGCGPSGHVMASDGAAPALALGGPAWSPCSRRQLLSLLSAGRARCLWDPPGPLSGPAGQPPEVQPGLYYGADEQCRVAFGPTAVACTFRGEHLDMCQALSCHTDPLDPSSCSRLLIPLLDGTECGVGKWCSKGHCRSLAELAPVGVVHGHWSGWGPASPCSRSCGGGVITRRRRCNNPRPAFGGRTCVGSDLQAEMCNTQACEKTQLEFMSEQCAQTDSEPLRLSPGGSTAFYRWGTAEQYSEGNALCRHVCRAVGESFMVRRGDRFLDGTRCVPGDPQEDGALRLCVSGSCRTFGCDGRMDSGQVRDVCQVCGGDNSTCQPQSGSFTAGRAREYVTFLTVTPNLTSIYIINRRPLFTHLAVRVRGRYVVAGNGSASASTSYPSLLEDNRVEYRVTLSEDRLPRREEIRIRGPTRDDMEIQVYRRYSEEYGSPARPDITFIYFQPEQRRAWAWVPVQGPCSVSCGAGLRQVTYRCRDQSRSEWVEAAHCAGSQPPVAWSETCTPGPCPPHWEAGDFGPCSASCGGGLREREVRCVEARGGLLRTVPRSRCRALAPQPAAVDTCNSQPCPQRETDACSSACGADPAVQNTTCVPGSDGTGLLVTAGPCSADEKPPAPEPCVEATCPPGWDQLDVRPPGREAASPAGGPGLEALAAHVWTPLAGPCSVSCGQGLVELRFVCMDTALRTPVREELCDLASKPGSRREACQAAPCPARWETRALAPCPVTCGGGQVPLAVRCVRMDQGRLVSLPHSKCWPMPRPRTLEDCSLEPCPARWRYKLAACSLSCGGGVAQRILYCARAHGEDTDEEILPDTQCQGLPRPEQQEACSPEPCPPRWKVTSLGPCSASCGLGTATRSLACVRLDHGQDTEVDGAACAGLVQPQASIPCIVADCAYRWHVSAWTQCSVSCGEGIQHRHDACLGPGAQVPVPADFCQHLPKPVTVRGCQAGPCVGQGMASPAPREEATAPGQTTAATAASLEWPQPHTRLLSPAQGRLPGPQESPVETSVCGRQHLGPTGIIDMRGTARPDCAVAIGRPLGEVVTLRFLEGSLNCSAGEMLLLWGRLVWRKMCGKPAGMVFSSQANTLLVRQRLVRPGGGVLLRYSSQPALGAFHRGCDMQLFGPRGEISSPSMSPDGRNVGGCRIFIDVAPWARIAIHALTVDSGTRAEGTDASYILIRDIHSLRTTAFRGQKTLYWESEGSQAEMEFSQGFLEAHASLRGQYWTLHTRAG", "length": 1470, "header": "tr|A0A3Q1M0L5-1|A0A3Q1M0L5_BOVIN Isoform 1 of A disintegrin and metalloproteinase with thrombospondin motifs 13 OS=Bos taurus OX=9913 GN=ADAMTS13 PE=4 SV=2 CANONICAL=A0A3Q1M0L5-1" }, "locus": { "chromosome": "11", "start_pos": 104351325, "end_pos": 104318053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073324.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073324.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066754.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066754.2" } ] } }, { "isoform_ac": "A0ABI0NJS8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJS8/entry", "sequence": { "sequence": "MPAASLRKDSWAQPGWESALSPAGLLMPSPGCVCCKHGPRLSALPAPSPGRPLAPRLRRRAAGHVLHLELLVAVGPDVHRTHGEETERYVLTNLNMGSELLRDPSLGAQFRVHLVKMVILTQPEDAPEITANITASLLSVCEWSRTVNPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSSSWSCLITEDTGFDLGLTIAHEIGHSFGLEHDGVPGSGCGPSGHVMASDGAAPALALGGPAWSPCSRRQLLSLLSAGRARCLWDPPGPLSGPAGQPPEVQPGLYYGADEQCRVAFGPTAVACTFRGEHLDMCQALSCHTDPLDPSSCSRLLIPLLDGTECGVGKWCSKGHCRSLAELAPVGVVHGHWSGWGPASPCSRSCGGGVITRRRRCNNPRPAFGGRTCVGSDLQAEMCNTQACEKTQLEFMSEQCAQTDSEPLRLSPGGSTAFYRWGTAEQYSEGNALCRHVCRAVGESFMVRRGDRFLDGTRCVPGDPQEDGALRLCVSGSCRTFGCDGRMDSGQVRDVCQVCGGDNSTCQPQSGSFTAGRAREYVTFLTVTPNLTSIYIINRRPLFTHLAVRVRGRYVVAGNGSASASTSYPSLLEDNRVEYRVTLSEDRLPRREEIRIRGPTRDDMEIQVYRRYSEEYGSPARPDITFIYFQPEQRRAWAWVPVQGPCSVSCGAGLRQVTYRCRDQSRSEWVEAAHCAGSQPPVAWSETCTPGPCPPHWEAGDFGPCSASCGGGLREREVRCVEARGGLLRTVPRSRCRALAPQPAAVDTCNSQPCPQRETDACSSACGADPAVQNTTCVPGSDGTGLLVTAGPCSADEKPPAPEPCVEATCPPGWDQLDVRPPGREAASPAGGPGLEALAAHVWTPLAGPCSVSCGQGLVELRFVCMDTALRTPVREELCDLASKPGSRREACQAAPCPARWETRALAPCPVTCGGGQVPLAVRCVRMDQGRLVSLPHSKCWPMPRPRTLEDCSLEPCPARWRYKLAACSLSCGGGVAQRILYCARAHGEDTDEEILPDTQCQGLPRPEQQEACSPEPCPPRWKVTSLGPCSASCGLGTATRSLACVRLDHGQDTEVDGAACAGLVQPQASIPCIVADCAYRWHVSAWTQCSVSCGEGIQHRHDACLGPGAQVPVPADFCQHLPKPVTVRGCQAGPCVGQGMASPAPREEATAPGQTTAATAASLEWPQPHTRLLSPAQGRLPGPQESPVETSVCGRQHLGPTGIIDMRGTARPDCAVAIGRPLGEVVTLRFLEGSLNCSAGEMLLLWGRLVWRKMCGKPAGMVFSSQANTLLVRQRLVRPGGGVLLRYSSQPALGAFHRGCDMQLFGPRGEISSPSMSPDGRNVGGCRIFIDVAPWARIAIHALTVDSGTRAEGTDASYILIRDIHSLRTTAFRGQKTLYWESEGSQAEMEFSQGFLEAHASLRGQYWTLHTRAG", "length": 1454, "header": "tr|A0ABI0NJS8-1|A0ABI0NJS8_BOVIN Computationally mapped isoform of A disintegrin and metalloproteinase with thrombospondin motifs 13 OS=Bos taurus OX=9913 GN=ADAMTS13 PE=4 SV=1 CANONICAL=A0A3Q1M0L5-1" }, "locus": { "chromosome": "11", "start_pos": 104351325, "end_pos": 104320815, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144734.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144734.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104751.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104751.1" } ] } }, { "isoform_ac": "F1MVP0-1", "url": "https://www.uniprot.org/uniprotkb/F1MVP0/entry", "sequence": { "sequence": "MAPSAQGRGVRGTLTSALFFLSCWALPDPRQVLEPADVTSYFGPDAAFEGPRLSALPAPSPGRPLAPRLRRRAAGHVLHLELLVAVGPDVHRTHGEETERYVLTNLNMGSELLRDPSLGAQFRVHLVKMVILTQPEDAPEITANITASLLSVCEWSRTVNPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSSSWSCLITEDTGFDLGLTIAHEIGHSFGLEHDGVPGSGCGPSGHVMASDGAAPALALGGPAWSPCSRRQLLSLLSAGRARCLWDPPGPLSGPAGQPPEVQPGLYYGADEQCRVAFGPTAVACTFRGEHLDMCQALSCHTDPLDPSSCSRLLIPLLDGTECGVGKWCSKGHCRSLAELAPVGVVHGHWSGWGPASPCSRSCGGGVITRRRRCNNPRPAFGGRTCVGSDLQAEMCNTQACEKTQLEFMSEQCAQTDSEPLRLSPGGSTAFYRWGTAEQYSEGNALCRHVCRAVGESFMVRRGDRFLDGTRCVPGDPQEDGALRLCVSGSCRTFGCDGRMDSGQVRDVCQVCGGDNSTCQPQSGSFTAGRAREYVTFLTVTPNLTSIYIINRRPLFTHLAVRVRGRYVVAGNGSASASTSYPSLLEDNRVEYRVTLSEDRLPRREEIRIRGPTRDDMEIQGNRRVLVGLWRRPGRAEHDVCAGVRWHGAVGDC", "length": 691, "header": "tr|F1MVP0-1|F1MVP0_BOVIN Computationally mapped isoform of ADAM metallopeptidase with thrombospondin type 1 motif 13 OS=Bos taurus OX=9913 GN=ADAMTS13 PE=4 SV=5 CANONICAL=A0A3Q1M0L5-1" }, "locus": { "chromosome": "11", "start_pos": 104340876, "end_pos": 104318053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020085.8", "url": "https://www.ensembl.org/id/ENSBTAT00000020085.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020085.8", "url": "https://www.ensembl.org/id/ENSBTAP00000020085.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:532272", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532272", "resource": "KEGG Pathway" }, { "id": "R-BTA-5173214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "resource": "Reactome", "description": "O-glycosylation of TSR domain-containing proteins" }, { "id": "R-BTA-9769739", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769739", "resource": "Reactome", "description": "Regulation of clotting cascade" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0L5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0L5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0L5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0L5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0L5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0L5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5" } ], "pmid": "" }, { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0L5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5" } ], "pmid": "" }, { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0L5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5" } ], "pmid": "" }, { "name": "peptide catabolic process", "id": "GO:0043171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043171", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0L5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1292, "end_pos": 1294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 558, "end_pos": 560, "annotation": "n_glycosylation_sequon" }, { "start_pos": 585, "end_pos": 587, "annotation": "n_glycosylation_sequon" }, { "start_pos": 614, "end_pos": 616, "annotation": "n_glycosylation_sequon" }, { "start_pos": 829, "end_pos": 831, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], 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"Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 210, "end_pos": 210, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "PRU00276", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00276" }, { "id": "PIRSR613273-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR613273-2" } ], "binding_site_uniprot": 214, "amino_acid": "Glu", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 214, "end_pos": 214, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "PRU00276", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00276" }, { "id": "PIRSR613273-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR613273-2" } ], "binding_site_uniprot": 220, "amino_acid": "Leu", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 220, "end_pos": 220, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "PRU00276", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00276" }, { "id": "PIRSR613273-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR613273-2" } ], "binding_site_uniprot": 222, "amino_acid": "Leu", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 222, "end_pos": 222, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1M0L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0L5" }, { "id": "PRU00276", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00276" }, { 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"url": "https://www.ensembl.org/id/ENSBTAP00000063561.1" } ] } }, { "isoform_ac": "E1BN05-1", "url": "https://www.uniprot.org/uniprotkb/E1BN05/entry", "sequence": { "sequence": "MAGGAERGRGGAGWGLRGALAAVALLSALNAAGTVFALCQWRGLSAALRALEEQRGREQREDSALRAFLAELSRAPRRAPAPPLDPASAARNKRSHGGEPAQHIRAESHDMLMMMTYSMVPIRVMVDLCNSTRGICLTGPPGASGLPGHNGSDGQPGPQGPKGEKGANGKRGKMGPPGATGTPGEKGDPGELGLPGSEGQAGQKGDKGDKGDVPNDVLPAGAKGDQGPPGPPGPPGPPGPPGPPGPPGSRRSKGPRQPNMFNGQCPGETCAVPNDDTLVGKTDEKVSEHHSPQAESMITSIGSPIQVLKVKETFGTWIRESANKSDERIWVTEHFSGIRVKEFEDQPSLLNGSYTLIHLPYYFHGCGHTVHNNSLYYHKGGSNTIVRFEFGKETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLEERTFSVVQHINTTYPKSKAGNAFIARGILYVTDTKDTRITFAFDLLGGKQINANFALRTSQSVLAMLSYNMRDQHLYSWEDGHLMLYPVQFLSAALHQ", "length": 545, "header": "tr|E1BN05-1|A0A3Q1M0P7_BOVIN Computationally mapped isoform of Gliomedin OS=Bos taurus OX=9913 GN=GLDN PE=4 SV=3 CANONICAL=A0A3Q1M0P7-1" }, "locus": { "chromosome": "10", "start_pos": 59006086, "end_pos": 58951444, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003336.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003336.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003336.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003336.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 188, "start_aa": "Thr", "end_pos": 188, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr188", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:781681", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781681", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZR06-1", "protein_name": "Gliomedin", "gene_name": "GLDN", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEADGRALRCVLAAVGLLSALSAAGTLFLLVQWRELSAALRELEAARIPAANGSVRDPLGSAGPGHPPPARSRRSRRGHVRAESEEMLMMLTYSMVPVRVMVDLCNSTKGICLTGPPGPPGPPGLDGLPGYNGSDGAPGVPGQKGEPGLNGKRGKMGVPGPKGDQGEKGEPGEIGLPGKDGMPGVKGARGAKGEKGDANNDVILEGAKGEPGPPGPPGPPGPPGPPGKRRGKAQLQENVYSNKCTGETCAVPNDDTLAGKAEDRPSDHSKKAECVITSVGSPVHFVSVQQTFGTWMREPANVSDERIWLTMHFSGNSIKEYENSNALLNDTYRIINITGFFYGCGHAVQNNHLYYQKGGTNVILKLGLDKASLGTLLIENALYHGRNYLFSNSKTYFNVAVDEKGLWIIYASSTDETIIVAHIDEETFSIIRHINTTYPKSKAGNAFIACGIMYVTDTKDMTVSFAFDLLKEKQIDARFELRSSQSVLAMLSYSLRDKNLYTWENGSLMVYPVHFGG", "length": 517 }, "evidence": [ { "id": "A0A3Q1M0P7", "url": "https://omabrowser.org/oma/group/A0A3Q1M0P7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RYN3-1", "protein_name": "Gliomedin", "gene_name": "GLDN", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGGAEQGRRGAEWGLRGALAAVALLSALNAAGTVFALCQWRELSAALRALEVQRGRELREDSALRAFLTELSHAPRQAPAPPPDPAIAARNKRSHGGEPAQHIRTESHDMLMMMTYSMVPIRVMVDLCNSTRGICLTGPPGPAGPPGIGGLPGHNGSDGQPGPQGPKGEKGANGKRGKMGPPGATGTPGEKGDPGELGLTGNEGPVGQKGDKGDKGDVSNDVLPAGAKGDQGPPGPPGPAGPPGPPGPPGPPGSRRSKGPRQPNMFNGQCPGETCAIPNDDTLIGKADEKVSEHHSPQAESLITSIGNPTQVLKVKETFGTWIRESANKSDERIWVTEHFSGIRVKEFEDQPSLLNGSYTLIHLPYYFHGCGHTVYNNSLYYHKGGSNTIVRFEFGKETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSMDGSSILVAQLDERTFSVVQHINTTYPKSKAGNAFIAQGILYVTDTKDMRVTFAFDLLAGKQINANFDLRTSQSVLAMLSYNMRDQHLYSWEDGHLMLYPVQFLSAVLNQ", "length": 551 }, "evidence": [ { "id": "A0A3Q1M0P7", "url": "https://omabrowser.org/oma/group/A0A3Q1M0P7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6ZMI3-1", "protein_name": "Gliomedin", "gene_name": "GLDN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARGAEGGRGDAGWGLRGALAAVALLSALNAAGTVFALCQWRGLSSALRALEAQRGREQREDSALRSFLAELSRAPRGASAPPQDPASSARNKRSHSGEPAPHIRAESHDMLMMMTYSMVPIRVMVDLCNSTKGICLTGPSGPPGPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIPGAAGNPGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPGETCAIPNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFIHLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLDERTFSVVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQFLSTTLNQ", "length": 551 }, "evidence": [ { "id": "A0A3Q1M0P7", "url": "https://omabrowser.org/oma/group/A0A3Q1M0P7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BMF8-1", "protein_name": "Gliomedin", "gene_name": "Gldn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTRAAERGQGATGWGLRGALVAIALLSALNAAGTVFVLCQWRGLSAALRALEAQRGREQREDSALRAFLAELSRAPGRVPEPSQDPMSAARNKRSHNGEPASHIRAESQDMMMMMTYSMVPIRVMIDLCNSTQGICLTGPPGPPGPPGAGGLPGHNGSDGQPGLQGPKGEKGAIGKRGKMGLPGATGNPGEKGEKGDAGELGLPGNEGPPGQKGDKGDKGDVSNDVLLTGAKGDQGPPGPPGPPGPPGPPGSRRSKGPRPPNVFNSQCPGETCVIPNDDTLVGRADEKANERHSPQTESMITSIGNPAQVLKVRETFGTWMRESANKSDDRIWVTEHFSGIMVKEFKDLPALLNSSFTLLHLPHYFHGCGHAVYNNSLYYHKGGSNTIVRFEFGKETPQTLKLENALYFDRKYLFANSKTYFNIAVDEKGIWIIYASSVDGSSILVAQLDERTFSVTQHINTTYPKSKAGNAFIARGILYVTDTKDTRVTFAFDLLGGKQINANFDFRMSQSVLAMLSYNMRDQHLYSWEDGHLMLYPVQFLSAASSQR", "length": 549 }, "evidence": [ { "id": "A0A3Q1M0P7", "url": "https://omabrowser.org/oma/group/A0A3Q1M0P7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0P7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0P7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0P7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0P7" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0P7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0P7" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0P7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0P7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0P7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0P7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein binding involved in heterotypic cell-cell adhesion", "id": "GO:0086080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0086080", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0P7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0P7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 329, "end_pos": 331, "annotation": "n_glycosylation_sequon" }, { "start_pos": 357, "end_pos": 359, "annotation": "n_glycosylation_sequon" }, { "start_pos": 378, "end_pos": 380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M0P7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 551, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M0P7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0P7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M0P7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0P7" }, { "id": "PS51132", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51132" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Olfactomedin-like", "eco_id": "ECO_0000259", "start_pos": 299, "end_pos": 546, "start_aa": "Gln", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 188 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 }, { "start_pos": 156, "end_pos": 158 }, { "start_pos": 329, "end_pos": 331 }, { "start_pos": 357, "end_pos": 359 }, { "start_pos": 378, "end_pos": 380 }, { "start_pos": 464, "end_pos": 466 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M0S5-1", "uniprot_ac": "A0A3Q1M0S5", "uniprot_id": "A0A3Q1M0S5_BOVIN", "mass": { "chemical_mass": 34686.0, "monoisotopic_mass": 34686.0 }, "refseq": { "ac": "NP_001377237", "name": "olfactory receptor family 8 subfamily AR member 1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377237" }, "gene_names": [ { "name": "OR8AR1", "type": "recommended", "evidence": [ { "id": "A0A3Q1M0S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0S5" } ] }, { "name": "OR8AR1", "type": "synonym", "evidence": [ { "id": "NP_001377237", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377237" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0A3Q1M0S5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0S5/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 143", "type": "synonym", "evidence": [ { "id": "NP_001377237", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377237" } ] }, { "name": "olfactory receptor family 8 subfamily AR member 1", "type": "synonym", "evidence": [ { "id": "NP_001377237", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377237" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377237" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0S5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0S5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0S5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0S5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8AR1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0S5", "locus": { "chromosome": "9", "start_pos": 104334201, "end_pos": 104335133, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050546", "url": "https://www.ensembl.org/id/ENSBTAG00000050546" } ] } } ], "crossref": [ { "id": "A0A3Q1M0S5", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0S5", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15405", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15405", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "782191", "url": "https://www.ncbi.nlm.nih.gov/gene/782191", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782191", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782191", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377237", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0S5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0S5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0S5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0S5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTMENTSSVSEFILMGLTDQPKLQLPLFSLFLLNYLVTVVGNLFLMILICLNSHLHTPMYFYLFNLSFIDLCYSSVFTPKMLISFISNRNVISFTGCMSQLFFFCFFVNSECYVLTAMAYDRYVAICKPLLYTVAMSPQVCSQLMSGSYVMGFAGAIVHTGSMMRLIFCDSNIINHYLCDIFPLLQLSCSSTYANEIVVSAVVGTVVILSSLIIFISYALILFNILHIPSSKGWSKALSTCGSHITTVSLFYGFGLLTHVKLPSSGFVDQGKFFTVFSTNVVPMLNPLIYSLRNKDVKIAVKKILKRITN", "length": 310, "header": "tr|A0A3Q1M0S5-1|A0A3Q1M0S5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8AR1 PE=3 SV=2 CANONICAL=A0A3Q1M0S5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0S5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0S5/entry", "sequence": { "sequence": "MTMENTSSVSEFILMGLTDQPKLQLPLFSLFLLNYLVTVVGNLFLMILICLNSHLHTPMYFYLFNLSFIDLCYSSVFTPKMLISFISNRNVISFTGCMSQLFFFCFFVNSECYVLTAMAYDRYVAICKPLLYTVAMSPQVCSQLMSGSYVMGFAGAIVHTGSMMRLIFCDSNIINHYLCDIFPLLQLSCSSTYANEIVVSAVVGTVVILSSLIIFISYALILFNILHIPSSKGWSKALSTCGSHITTVSLFYGFGLLTHVKLPSSGFVDQGKFFTVFSTNVVPMLNPLIYSLRNKDVKIAVKKILKRITN", "length": 310, "header": "tr|A0A3Q1M0S5-1|A0A3Q1M0S5_BOVIN Isoform 1 of 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"categories": [ "Protein" ] }, { "id": "E1BFR1-1", "url": "https://www.uniprot.org/uniprotkb/E1BFR1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAYSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPTSSAAPSVMDLSSRASAPIHPGIPPPNCVQSPMRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL", "length": 295, "header": "tr|A0A3Q1M0U0-1|A0A3Q1M0U0_BOVIN Isoform 1 of HLF transcription factor, PAR bZIP family member OS=Bos taurus OX=9913 GN=HLF PE=3 SV=1 CANONICAL=A0A3Q1M0U0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0U0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U0/entry", "sequence": { "sequence": 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"id": "bta:516069", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516069", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RSF5-1", "protein_name": "HLF transcription factor, PAR bZIP family member", "gene_name": "HLF", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSAAPSVMDLSSRASAPIHPGIPSPTCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL", "length": 295 }, "evidence": [ { "id": "A0A3Q1M0U0", "url": "https://omabrowser.org/oma/group/A0A3Q1M0U0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H1C2-1", "protein_name": "Hepatic leukemia factor", "gene_name": "Hlf", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEKMSRQLPLNPTFIPPPYGVLRSLLENPLKLPLHPEDAFSKDKDKGKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSTAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDAIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL", "length": 295 }, "evidence": [ { "id": "A0A3Q1M0U0", "url": "https://omabrowser.org/oma/group/A0A3Q1M0U0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q16534-1", "protein_name": "Hepatic leukemia factor", "gene_name": "HLF", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL", "length": 295 }, "evidence": [ { "id": "A0A3Q1M0U0", "url": "https://omabrowser.org/oma/group/A0A3Q1M0U0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BW74-1", "protein_name": "Hepatic leukemia factor", "gene_name": "Hlf", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKMSRQLPLNPTFIPPPYGVLRSLLENPLKLPLHPEDAFSKEKDKGKKLDDESSSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSTAPSVMDLSSRATAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL", "length": 295 }, "evidence": [ { "id": "A0A3Q1M0U0", "url": "https://omabrowser.org/oma/group/A0A3Q1M0U0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U0" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U0" } ], "pmid": "" }, { "name": "rhythmic process", "id": "GO:0048511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048511", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U0" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U0" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0U0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M0U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0U0" }, { "id": "PS50217", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50217" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BZIP", "eco_id": "ECO_0000259", "start_pos": 225, "end_pos": 288, "start_aa": "Asp", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M0V4-1", "uniprot_ac": "A0A3Q1M0V4", "uniprot_id": "A0A3Q1M0V4_BOVIN", "mass": { "chemical_mass": 97724.0, "monoisotopic_mass": 97724.0 }, "refseq": {}, "gene_names": [ { "name": "PACS2", "type": "recommended", "evidence": [ { "id": "A0A3Q1M0V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0V4" } ] } ], "protein_names": [ { "name": "Phosphofurin acidic cluster sorting protein 2", "type": "synonym", "evidence": [ { "id": "A0A3Q1M0V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0V4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0V4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0V4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PACS2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0V4", "locus": { "chromosome": "21", "start_pos": 69683586, "end_pos": 69621608, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046346", "url": "https://www.ensembl.org/id/ENSBTAG00000046346" } ] } } ], "crossref": [ { "id": "A0A3Q1M0V4", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0V4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000046346", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046346", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR019381", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019381", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057541", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057541", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0V4", "url": "https://www.orthodb.org/?gene=A0A3Q1M0V4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13280", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13280", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13280:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13280:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10254", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10254", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25332", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25332", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M0V4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0V4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0V4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0V4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MXC5", "url": "https://www.uniprot.org/uniprotkb/G3MXC5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MXC5-1", "url": "https://www.uniprot.org/uniprotkb/G3MXC5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAERGRLGLAGAPAALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVETDLALTFSLQYPHFLKREGNKLQIMLQRRKRYKNRTILGYKTLAAGSINMAEVLQQPAEGGQVLSLCSNIKEAAVKVAEIWIFSLSSQPIDHEDSAMQAGPKAKSTENYSEEEYESFSSEQEASDDAVQGQDLDEDDFDVGKPKKQRRSIVRTPSMTRQNFKQKVVALLRRFKVSDEVLDSEQDPAEHVPEVEEDLDLLYDTLDMENPSDSGPDMEDDDSVLSTPKPKLRPYFEGLSHSSSQTEIGSVHSARSQREPPSPADVPEKTRVLGGKQPSDSVSDSVAHSTPAPGEPPAPPEESPEVETSALDLFAEKLPPSGRITKTESLVIPSTRSEGKQAGRRGRSTSLKERQPARPQNERANSLDNERCPDTRSQLQIPRKTVYDQLNHILISDDQLPENIILVNTSDWQGQFLSEVLQRHTLPVVCTCSAADVQAAFSTIVSRIQRYCNCNSQPPTPVKIAVAGAQHYLSAVLRLFVEQLSHKTPDWLGYMRFLVIPLGSHPVARYLGSVDYRYNNFFQDLAWRDLFNKLEAQSAVQDTPDIVSRITQYISGANCAHQLPIAEAMLTYKQKSPDEESSQKFIPFVGVVKVGIVEPSSAASGDSDDAAPSGSSVLSSTPPSTSPAAKEASPTPPSSPSVSGGLSSPSQGVGAELMGLQVDYWTAAQPADRKRDAEKKDSPTTKNTLKCTFRSLQVSRLPSSGEAVATPTMSMTVVTKEKNKKVMFLPKKTKDKDVESKSQCIEGISRLICTAKHQQNMLRVLIDGVEWNDVKFFQLAAQWSSHVKHFPICIFGHSKSTF", "length": 888, "header": "tr|A0A3Q1M0V4-1|A0A3Q1M0V4_BOVIN Isoform 1 of Phosphofurin acidic cluster sorting protein 2 OS=Bos taurus OX=9913 GN=PACS2 PE=3 SV=3 CANONICAL=A0A3Q1M0V4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0V4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0V4/entry", "sequence": { "sequence": "MAERGRLGLAGAPAALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVETDLALTFSLQYPHFLKREGNKLQIMLQRRKRYKNRTILGYKTLAAGSINMAEVLQQPAEGGQVLSLCSNIKEAAVKVAEIWIFSLSSQPIDHEDSAMQAGPKAKSTENYSEEEYESFSSEQEASDDAVQGQDLDEDDFDVGKPKKQRRSIVRTPSMTRQNFKQKVVALLRRFKVSDEVLDSEQDPAEHVPEVEEDLDLLYDTLDMENPSDSGPDMEDDDSVLSTPKPKLRPYFEGLSHSSSQTEIGSVHSARSQREPPSPADVPEKTRVLGGKQPSDSVSDSVAHSTPAPGEPPAPPEESPEVETSALDLFAEKLPPSGRITKTESLVIPSTRSEGKQAGRRGRSTSLKERQPARPQNERANSLDNERCPDTRSQLQIPRKTVYDQLNHILISDDQLPENIILVNTSDWQGQFLSEVLQRHTLPVVCTCSAADVQAAFSTIVSRIQRYCNCNSQPPTPVKIAVAGAQHYLSAVLRLFVEQLSHKTPDWLGYMRFLVIPLGSHPVARYLGSVDYRYNNFFQDLAWRDLFNKLEAQSAVQDTPDIVSRITQYISGANCAHQLPIAEAMLTYKQKSPDEESSQKFIPFVGVVKVGIVEPSSAASGDSDDAAPSGSSVLSSTPPSTSPAAKEASPTPPSSPSVSGGLSSPSQGVGAELMGLQVDYWTAAQPADRKRDAEKKDSPTTKNTLKCTFRSLQVSRLPSSGEAVATPTMSMTVVTKEKNKKVMFLPKKTKDKDVESKSQCIEGISRLICTAKHQQNMLRVLIDGVEWNDVKFFQLAAQWSSHVKHFPICIFGHSKSTF", "length": 888, "header": "tr|A0A3Q1M0V4-1|A0A3Q1M0V4_BOVIN Isoform 1 of Phosphofurin acidic cluster sorting protein 2 OS=Bos taurus OX=9913 GN=PACS2 PE=3 SV=3 CANONICAL=A0A3Q1M0V4-1" }, "locus": { "chromosome": "21", "start_pos": 69682582, "end_pos": 69621809, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081554.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081554.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063623.3", "url": "https://www.ensembl.org/id/ENSBTAP00000063623.3" } ] } }, { "isoform_ac": "G3MXC5-1", "url": "https://www.uniprot.org/uniprotkb/G3MXC5/entry", "sequence": { "sequence": "MAERGRLGLAGAPAALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLVVFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVETDLALTFSLQYPHFLKREGNKLQIMLQRRKRYKNRTILGYKTLAAGSINMAEVLQQPAEGGQVLSLCSNIKEAAVKVAEIWIFSLSSQPIDHEDSAMQAGPKAKSTENYSEEEYESFSSEQEASDDAVQGQDLDEDDFDVGKPKKQRRSIQQNFKQKVVALLRRFKVSDEVLDSEQDPAEHVPEVEEDLDLLYDTLDMENPSDSGPDMEDDDSVLSTPKPKLRPYFEGLSHSSSQTEIGSVHSARSQREPPSPADVPEKTRVLGGKQPSDSVSDSVAHSTPAPGEPPAPPEESPEVETSALDLFAEKLPPSGRITKTESLVIPSTRSEGKQAGRRGRSTSLKERQPARPQNERANSLDNERCPDTRSQLQIPRKTVYDQLNHILISDDQLPENIILVNTSDWQGQFLSEVLQRHTLPVVCTCSAADVQAAFSTIVSRIQRYCNCNSQPPTPVKIAVAGAQHYLSAVLRLFVEQLSHKTPDWLGYMRFLVIPLGSHPVARYLGSVDYRYNNFFQDLAWRDLFNKLEAQSAGHAGHRVKNHPVHFGGQLRPPAAHRGGHADLQAEEVVKVGIVEPSSAASGDSDDAAPSGSSVLSSTPPSTSPAAKEASPTPPSSPSVSGGLSSPSQGVGAELMGLQVDYWTAAQPADRKRDAEKKDSPTTKNTLKCTFRSLQVSRLPSSGEAVATPTMSMTVVTKEKNKKVMFLPKKTKDKDVESKSQCIEGISRLICTAKHQQNMLRVLIDGVEWNDVKFFQLAAQWSSHVKHFPICIFGHSKSTF", "length": 865, "header": "tr|G3MXC5-1|A0A3Q1M0V4_BOVIN Computationally mapped isoform of Phosphofurin acidic cluster sorting protein 2 OS=Bos taurus OX=9913 GN=PACS2 PE=3 SV=4 CANONICAL=A0A3Q1M0V4-1" }, "locus": { "chromosome": "21", "start_pos": 69682582, "end_pos": 69621809, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000062993.4", "url": "https://www.ensembl.org/id/ENSBTAT00000062993.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054190.4", "url": "https://www.ensembl.org/id/ENSBTAP00000054190.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 721, "start_aa": "Thr", "end_pos": 721, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr721", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M0W3-1", "uniprot_ac": "A0A3Q1M0W3", "uniprot_id": "A0A3Q1M0W3_BOVIN", "mass": { "chemical_mass": 53146.0, "monoisotopic_mass": 53146.0 }, "refseq": { "ac": "XP_024848197", "name": "keratin, type II cuticular Hb1-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848197" }, "gene_names": [ { "name": "LOC787600", "type": "recommended", "evidence": [ { "id": "A0A3Q1M0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W3" } ] }, { "name": "LOC112446672", "type": "synonym", "evidence": [ { "id": "A0A3Q1M0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W3" } ] }, { "name": "LOC112446673", "type": "synonym", "evidence": [ { "id": "XP_024848197", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848197" }, { "id": "A0A3Q1M0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W3" } ] } ], "protein_names": [ { "name": "IF rod domain-containing protein", "type": "recommended", "evidence": [ { "id": "A0A3Q1M0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W3/entry#names_and_taxonomy" } ] }, { "name": "keratin, type II cuticular Hb1-like", "type": "synonym", "evidence": [ { "id": "XP_024848197", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848197" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC787600", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W3", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000052798", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000052798", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "112446673", "url": "https://www.ncbi.nlm.nih.gov/gene/112446673", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032444", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032444", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:112446673", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112446673", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SHFRYSS", "url": "https://omabrowser.org/oma/group/SHFRYSS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0W3", "url": "https://www.orthodb.org/?gene=A0A3Q1M0W3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45616", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45616", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45616:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45616:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16208", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16208", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024848197", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848197", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0W3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTCGSACFSSRSGVRSSSSCVTTQRYAPGRTFSCVSACGPRPSRCCITAAPYRGVSCYRGLTGGFSSRSVCGGSRAGSSSRSFGYRSGGPSPPCITSVSVNQSLLKPLNLEIDPNAQRIKHQEKEQIKSLNSKFAAFIDKVCFLEQQNKLLETKWKFYQNQRCCESNLEPLFNGYIETLRREAERVEADTGRLASELNSLQEVLQGYKKKYEEEVALKTTAENEFVKIKQEVNRAYVLKGDLEANAHSLVEEVGFLKTLYEEELRVMQAHISDTSVVVKMDNSRYLNMDSIVAEIKAHYDEIASRSRAEAESWYRSKYEEIKATVIRHGETLRRTKEEINELNRLIQRLTAEIENAKSQNSKLEAAVTQAEQQGEAALNDARGKLAGLEKTLQKAKQDMACLLKEYQEVMSAKLGLDIEIATYRRLLEGEEQRLCEGISAVNVRVSSSRGGVVCGDLSATRTCGIGSYGVGACGSSCKKC", "length": 480, "header": "tr|A0A3Q1M0W3-1|A0A3Q1M0W3_BOVIN Isoform 1 of IF rod domain-containing protein OS=Bos taurus OX=9913 GN=LOC787600 PE=3 SV=1 CANONICAL=A0A3Q1M0W3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0W3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W3/entry", "sequence": { "sequence": "MTCGSACFSSRSGVRSSSSCVTTQRYAPGRTFSCVSACGPRPSRCCITAAPYRGVSCYRGLTGGFSSRSVCGGSRAGSSSRSFGYRSGGPSPPCITSVSVNQSLLKPLNLEIDPNAQRIKHQEKEQIKSLNSKFAAFIDKVCFLEQQNKLLETKWKFYQNQRCCESNLEPLFNGYIETLRREAERVEADTGRLASELNSLQEVLQGYKKKYEEEVALKTTAENEFVKIKQEVNRAYVLKGDLEANAHSLVEEVGFLKTLYEEELRVMQAHISDTSVVVKMDNSRYLNMDSIVAEIKAHYDEIASRSRAEAESWYRSKYEEIKATVIRHGETLRRTKEEINELNRLIQRLTAEIENAKSQNSKLEAAVTQAEQQGEAALNDARGKLAGLEKTLQKAKQDMACLLKEYQEVMSAKLGLDIEIATYRRLLEGEEQRLCEGISAVNVRVSSSRGGVVCGDLSATRTCGIGSYGVGACGSSCKKC", "length": 480, "header": "tr|A0A3Q1M0W3-1|A0A3Q1M0W3_BOVIN Isoform 1 of IF rod domain-containing protein OS=Bos taurus OX=9913 GN=LOC787600 PE=3 SV=1 CANONICAL=A0A3Q1M0W3-1" }, "locus": { "chromosome": "5", "start_pos": 27644675, "end_pos": 27639403, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154447.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154447.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106105.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106105.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:112446673", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:112446673", "resource": "KEGG Pathway" }, { "id": "R-BTA-6805567", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "resource": "Reactome", "description": "Keratinization" }, { "id": "R-BTA-6809371", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A075B5S0-1", "protein_name": "Immunoglobulin heavy variable 16-1", "gene_name": "Ighv16-1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "EVQLVESGGSLGQPGGSTKLSCEEASGFTFSDHWMDWFRQAPGMRLEWLANTNHDESGKGYAESVKDRFSISRDNSENLLYLQMNSLRNEDTALYYCAR", "length": 99 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A075B603-1", "protein_name": "T cell receptor alpha variable 6D-6", "gene_name": "Trav6-6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDSSPGFVAVILLILGRTHGDSVTQTEGPVTVSESESLIINCTYSATSIAYPNLFWYVRYPGEGLQLLLKVITAGQKGSSRGFEATYNKETTSFHLQKASVQESDSAVYYCALG", "length": 114 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A075B625-1", "protein_name": "T cell receptor alpha variable 4N-3", "gene_name": "Trav4n-3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERNLGAVLGILWVQICWVSGDKVKQSPSALSLQEGTNSALRCNFSIAATTVQWFLQNPRGSLMNLFYLVPGTKENGRLKSAFDSKESYSTLHIRDAQLEDSGTYFCAAE", "length": 110 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A075B695-1", "protein_name": "T cell receptor alpha variable 9D-3", "gene_name": "Trav9d-3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLALLPVLGIHFLLRDAQAQSVTQPDARVTVSEGASLQLRCKYSYFGTPYLFWYVQYPRQGLQLLLKYYPGDPVVQGVNGFEAEFSKSNSSFHLRKASVHWSDWAVYFCAVS", "length": 113 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A075B6B4-1", "protein_name": "T cell receptor alpha variable 6-4", "gene_name": "Trav6-4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNTSPVLVTVMLLFMLGMRKTHGDSVTQKQGQVTLSEDDFLFINCTYSTTTYPTLLWYVQYLGQGPQLLLKVTTANNKGISRGFEATYDKGTTSFHLQKASVQESDSAVYFCALV", "length": 115 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A075B6D8-1", "protein_name": "T cell receptor alpha variable 3-3", "gene_name": "Trav3-3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "GEQVEQRPPHLSVREGDSAVITCTYTDPNSYYFFWYKQEPGASLQLLMKVFSSTEINEGQGFTVLLNKKDKRLSLNLTAAHPGDSAAYFCAV", "length": 92 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A075B759-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase A-like 4E", "gene_name": "PPIAL4E", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVNSVVFFEITRDGKPLGRISIKLFADKIPKTAENFRALSTGEKGFRYKGSCFHRIIPGFMCQGGDFTRPNGTGDKSIYGEKFDDENLIRKHTGSGILSMANAGPNTNGSQFFICAAKTEWLDGKHVAFGKVKERVNIVEAMEHFGYRNSKTSKKITIADCGQF", "length": 164 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A075B767-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase A-like 4H", "gene_name": "PPIAL4H", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVNSVVFFDITVDGKPLGRISIKLFADKIPKTAENFRALSTGEKGFRYKGSCFHRIIPGFMCQGGDFTRPNGTDDKSIYGEKFDDENLIRKHTGSGILSMVNAGPNTNGSQLFICTAKTEWLDGKHVAFGKVKERVNIVEAMEHFGYRNSKTSKKITIADCGQF", "length": 164 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A087WP50-1", "protein_name": "Secretoglobin, family 1B, member 15", "gene_name": "Scgb1b17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMLAGAVVIFGVALLLLSSWGDCGICPAMKEDVHLFLNGTSEEYVEYVKQYKDDPEILENTEKIKQCVDSTLMEEDKAHANGFIEKIEASPLC", "length": 93 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WPA9-1", "protein_name": "Secretoglobin, family 2B, member 18", "gene_name": "Scgb2b18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGTLLLLGLLVTGELSFQTSEACVSFFEGYASVLSGSRVWLYQELQAFDATAEEKVALEKIQSCYSEERIRNILLEPKIMEAMVASPECRSYHSFNNFRSILDFISNLLGE", "length": 112 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WPG5-1", "protein_name": "Predicted gene 13283", "gene_name": "Gm13283", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPVHLFLVGGVMLSCSPASSLDSGKSGSLHLERSETARFLADLRSVPGHQCLRDRTDFPCPWKEGTNITQMTLGETTSCYSQSLRQVLHRFDTEASRAAWHERALDQLLSSLWRELQVLKRPREQGQSCPLPFALAIRTYFRGFFRYLKAKAHSACSWEIVRVQLQVDLPAFPLSARRGPR", "length": 182 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WPY7-1", "protein_name": "RNA binding motif protein Y-linked family member 4", "gene_name": "Rbmyf4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAETNQPGKIFIGGLNIKTRQKTLQEIFGRFGPVARVILMRDRETKKSRGFAFLTFRRLADAKNAVKEMNGVILDGKRIKVKQARRPSSLESGSKKRPPSFSRTRGASRILKCGRGGRSRARSGPSCEGNLGGDRYTPNFNVSSSGRHFAVKRNPSSKRDDPPSKR", "length": 166 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WQA9-1", "protein_name": "Secretoglobin, family 2B, member 21", "gene_name": "Scgb2b21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGTLLLLGLLVTGELSFQTTEACVPFFEGYASVVSGSRVWMYQEFQAFDATAEEKVALEKIQGCYREESLRNILLEPKIMEAMVASPECLSYYSSNNIRCILDLLSKLLGQ", "length": 112 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WQJ0-1", "protein_name": "Secretoglobin, family 1B, member 11", "gene_name": "Scgb1b11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKLVAAVVILGAALLLLTSGGDCGICPAIKEDVRLFLNGTSEEYVEYVKQYKDDPVILENTAKINQCVDSTLTEKDMTHTTTFLKKIEDSLLC", "length": 93 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WQP8-1", "protein_name": "Predicted gene, 21698", "gene_name": "Gm21698", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRVNVDGRETREGRKDADLPSERNEGRRRWTWRMCMAHGQTTSPVPVKSKKQFEKEEKELIKKIQLTTEETNELRDRLIYVTKGSMNKRPYHRQTRHYKELKLKEKEIMTFLHDLEMKNMEARENNQELKKEKNFYRNLHTRILLGENLIKKKLAILQQESKEIHADWAIIQQRLVELNLSGKDEQEKTSNLEAQENQVSEAARELGLATAEEDSILQNELPCQEAPAEHHPQHPSSSSDESSSDESSYSTCPEWE", "length": 267 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WR36-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r90", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSQNEAMKTTEEVALQIVLLCQFGIGTMANILLFIHNFSPLLTGCQLRPKQVICTNMAVSSILILFMTVFPNNVFVVQRNLMNDLQCKLEYFLRMVARSINLCSTCVLSTYQFVTLLPGNFGEMMVRGRRSKVISYSCCSCWLFGVLYNVYIPMKVSGPQNTHNKTDIKSKWFCVTSGFSVGIMFLWFAHDAIFISIMIWTSVSMVLLLYRHYQRLQYIFPPHQGTRGYAEIRAAHSIAMLVVTFVSFYLLHCICFILHIVFVDSRLWLRHVGEVLTSSFPTISPLLLIFRDPSYPCSLIFNYRKPVI", "length": 309 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WR44-1", "protein_name": "BTB domain containing 35, family member 15", "gene_name": "Btbd35f15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIHALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYVLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WR49-1", "protein_name": "Secretoglobin, family 2B, member 11", "gene_name": "Scgb2b11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGTLLLLGLLVTGELSFQTSEACVSFFEGYASVLSGSRVWLYQELQAFDATAEEKVALEKIQGCYSEERIRNILLEPKIMEAMVASPECRSYHSLNNFRSILEFISNLLGE", "length": 112 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WSM5-1", "protein_name": "Predicted gene 29049", "gene_name": "Gm29049", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSLKKKSRRKPSSQALGNIVGCRISYGWKEGNEPVTHWKAIILGQLPTNPSLYLVKYDGIDSVYGQELHSDERILNLKVLPHKVVFLQVRDVHLASALVCREVQHKFEGKDGSEDNWSGMVLAQVPFLQDYFYISYKKDPVLYVYQLLDDYKEGNLHIIPETPLAEARSGDDNDFLIGSWVQYTRDDGSKKFGKVVYKVLANSTVYCIKFLGDLHIYVYTLVSNIT", "length": 227 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WSN2-1", "protein_name": "BTB domain containing 35, family member 16", "gene_name": "Btbd35f16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLLFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLNFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A087WUL8-1", "protein_name": "NBPF family member NBPF19", "gene_name": "NBPF19", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVVSAGPWSSEKAEMNILEINETLRPQLAEKKQQFRNLKEKCFLTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLFHSQERELTQLREKLREGRDASRSLNEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITYSNSHGPYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGLAIDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSIPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELVEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSIPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELVEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAIDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSIPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELVEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSIPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELVEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSIPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELVEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSIPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDPLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDPLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYILEQQCVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLAEKEPEVLQDPLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNSVLMEVEEPEVLQDSLDGCYSTPSMYFELPDSFQHYRSVFYSFEEEHISFALYLDNRFFTLTVTSLHLVFQMLVIFPQ", "length": 3843 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A087WXS9-1", "protein_name": "TBC1 domain family member 3I", "gene_name": "TBC1D3I", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKMKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF", "length": 549 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A087X179-1", "protein_name": "TBC1 domain family member 3E", "gene_name": "TBC1D3E", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDQAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKKSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKKGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF", "length": 549 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A0A0MQP3-1", "protein_name": "BTB domain containing 35, family member 12", "gene_name": "Btbd35f12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDSDLSITPLEVPQGLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYVLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A0A6YW58-1", "protein_name": "Immunoglobulin heavy variable V8-2", "gene_name": "Ighv8-2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRLTFSFLLLLPVPAYVLSQVTLKVSGPGILQPSQTLSLACTFSGISLSTSGMGLSWLRKPSGKALEWLASIWNNDNYYNPSLKSRLTISKETSNYQVFLKLTSVDTADSATYYGAWR", "length": 119 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A0A6YXW2-1", "protein_name": "Predicted gene, 20773", "gene_name": "Gm20773", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLMKKRRRKSSSNTLRNIVGCRISHSWKEGNEPVTQWKAIVLDQLPTNPSLYLVKYDGIDSIYGLELYSDDRILNLKVLPPIVVFPQVRDAHLARALVGRAVQHKFEGKDGSEVNWRGVVLAQVPIMKDLFYITYKKDPALYAYQLLDDYKEGNLHMIPDTPPAEERSGDDSDVLIGNWVEYTRKDGSKKFGKVVYQVLANPSVYFIKFHGDIHIYVYTMVPKIFKVEKS", "length": 232 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A0A6YXX7-1", "protein_name": "Predicted gene, 20807", "gene_name": "Gm20807", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLMKKRRRKSSSNTLRNIVGCRISHSWKEGNEPVTQWKAIVLDQLPTNPSLYLVKYDGIDSIYGLELYSDDRILNLKVLPPIVVFPQVRDAHLARALVGRAVQHTFEGKDGSEVNWRGVVLAQVPIMKDLFYITYKKDPALYAYQLLDDYKEGNLHMIPDTPPAEERSGDDSDVLIGNWVEYTRKDGSKKFGKVVYQVLANPSVYFIKFHGDIHIYVYTMVPKVLEVEKS", "length": 232 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A0B4J1J8-1", "protein_name": "T cell receptor gamma, variable 4", "gene_name": "Trgv4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKNPGSQALLPLYLPWEANLADENPLLKVVIFLCLLTFGHGKLEQPEISISRPRDETAQISCKVFIESFRSVTIHWYRQKPNQGLEFLLYVLATPTHIFLDKEYKKMEASKNPSASTSILTIYSLEEEDEAIYYCSYG", "length": 138 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A0G2JE01-1", "protein_name": "Predicted gene, 21663", "gene_name": "Gm21663", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRVNVDGRETREGRKDADPPSERNEGRRRWTWRMCMAHRQTTSPVPVKSKKQFEKEEKELIKKIQLTTEETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTFLHDLEMKNMEARENNQELKKEKNFYRNLHTRILLGENLIKKKLAILQQESKEIHADWAIIQQRLVELNLSGKDEQEKTSNLEAQENQVSEAARELGLATAEEDSILQNELPCQEAPAEHHPQHPSSSSDESSSDESSYSTCPEWE", "length": 267 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A0G2JGR8-1", "protein_name": "Predicted gene, 21680", "gene_name": "Gm21680", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRANVDGRETREGRKDADLPSESNEGRRRWTWRMWMAHRQTTSPVPVTSKKQFEKEEKELIKKIQLTTKEINELRDRLIYVTKGSMNKRPYHRQTRHYKELKLKEKEIMTYLHELEMKNMEARENKQELKKEKNFYRNLHTRILLEENLIKKKLVILQQESKEVHADWATIHQSLVELNLSGKDEQEKTSNLETQEHQVSEAARELVLATAEEDSILQNELPCQEAPAEHHPQHPPSSSDESSSDESSYSTCPEWE", "length": 267 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A0G2JMD5-1", "protein_name": "PRAME family member 33", "gene_name": "PRAMEF33", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLQAPSRLLELAGQSLLRNQFLTIFTLDELPREVFPLMFMEAFSMRRFEALKLMVQAWPFLRLPLGSLMKTPHLETLQAVLRGLDTLVAQKVRPRRWKLQVLDLQDVDENFWTIWSGARVLSCSPEAMSKRQTVEDCPRMGEHQPLKVFIDLCLKESTLDECLSYLFGWIHYRRGLVHLCCSKVQNYSMPTSSFRNLLERIYPDSIQELEVWKKCSLNKTGKFAPYLSQMSNLRELFLAFGYERELYVSVQWPCIPDLDSPFLCLYYPQMLYIKKISNIKEHLEHLLRYLKNPLGAFIFSDAYLADRDMECLSQYPSLSQLKELRLIHILMWTTNLQPLGALLEKVAATLKTLVLKDCRIQDPQLRVLLPALSHCSQLTTFNFHGNETSMNALKDLLRHTRGLSKLGLELYPAPLESLDYKGHVNWEILTPIRAELMRTLREVRQPKRIFFGPVPCPTCGSWPSEKVDFHLCS", "length": 474 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A0G2JNH3-1", "protein_name": "Olfactory receptor", "gene_name": "LOC124905359", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKIANNTVVTEFILLGLTQSQDIQLLVFVLILIFYLIILPGNFLIIFTIRSDPGLTAPLYFFLGNLAFLDASYSFIVAPRMLVDFFSEKKVISYRGCITQLFFLHFLGGGEGLLLVVMAFDRYIAICRPLHCSTVMNPRACYAMMLALWLGGFVHSIIQVVLILRLPFCGPNQLDNFFCDVRQVIKLACTDMFVVELLMVFNSGLMTLLCFLGLLASYAVILCHVRRAASEGKNKAMSMCTTRVIIILLMFGPAIFIYMCPFRALPADKMVSLFHTVIFPLMNPMIYTLRNQEVKTSMKRLLSRHVVCQVDFIIRN", "length": 316 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A0G2JTV6-1", "protein_name": "RIKEN cDNA 4931429L15 gene like", "gene_name": "4931429L15Rikl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQFNPFSQDTWRHGHRRAYSNISERLSCLTLQEPSVSHLYQIFSPGDRRSYLLDDSLSNSIQRESLAVPMGLEDSGSRGQQKQQQPGAVLEDLEEQEIAPTDVKYRLQLLDEAPLRSKSSSVQSQGHKPGWIPSSKTHREWFKPWKMDMTYPENERSHSGHTQGRRMTPRAQWRHVEYDSQDQDTQSPVWSQALFPGLDKSSQGVIQCTQHVSREREMVSGWSMTHAPQEMGQAKQGPAFLKTKGTAKFNVATTARMSCLPPLKLLEKKVKSRCPPNTPGIFQDWRAQPQGLYGSDERLLAPFEDQVNTRVTYMPLFTEKVKFVSPKTAVSNPKQTHSQLSRTNQPAFPGQFRNWTSGREHLEKGLPE", "length": 368 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2JVP7-1", "protein_name": "40S ribosomal protein S26", "gene_name": "Rps26-ps4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTKKRRNNGRTKKGRGHVQPIGCANCSWCVPKDKAIKKFVIWNIVETAAVRDISEARIFDAYVLPKLYVKLHYCVSLAIHSKVIRNQSHEARKDRTSPPRFRPAGAAPRPPPKPM", "length": 115 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2JW93-1", "protein_name": "High mobility group protein B4", "gene_name": "Hmgb4l4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGKDSKVRPKVNVSPYVHFMMDFRNQTREQQPNTYYDFTEFSRKCSEKWKTISKKEKKKYEALAKRDKDRYQREMRNYSGPRRERRRRDPDAPRKPPSSFLLFSQDHFDEIKEQHPNWTVAQVAKAAGRMWARCSEADKIPYEERAAVLRAKYLEEREAYYHQCQRGE", "length": 168 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2JW96-1", "protein_name": "Zinc finger protein 94 like 1", "gene_name": "Zfp94l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLPRGSCDVMLESLRNVASLGHRIGTPDGLLRLKREDMFWLLTVARWSSGSMGDKNLEDMEFLEEVGLRHLPHEELFCSQIWQRITRELTKVRDCRVRVGENGSPMKRDNREDEYSKHSSQNSVFQVHHRECHEEEANERDFGCSHHLRTSTGEKSYKCEKCHNASHWFSSLQSHQGVCDRPRWNKSVSQFKIFRQWPLFHYQQSMPNGENAQEYEACGNAGKNSSGQTALFVHTAEEPYSCEECGARFSQSSYLQVHQRVHTGEKPYKCEECGKGFGWLSQLHAHHQSHTGEKPYTCDACGKGFSYSSHLNIHCRIHTGEKPYQCEECGKGFSQASNLLAHQRGHTGEKPYQCDACGKGFSRISDFNIHIRVHTGEKPYKCEECGKGFSQASNLLAHQRGHTGEKPYKCNTCGKSFRRSSDLNVHCRIHTGEKPYRCEKCDKVFSQFSSLQVHQRVHTGEKPYQCSECGKGFSVGSQLQAHQRCHTGERPYQCEECGKGFCRASNFLAHHGVHTGEKPYRCDMCGKHFRQRSYLQAHHRVHTGEKQFRCEECGKGFSWSSYLQAHQRVHMGEKPYKCEECGKGFSWSSSLLTHQRVHAEDEGQKDLSSSGGSYRK", "length": 616 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2JYP5-1", "protein_name": "Olfactory receptor", "gene_name": "Or8g52b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPEGNHSRVTEFILTGLTDKPELQLPLFLLFLGIYLLTVLGNLGMIILILLSSHLQTPMYFFLSGLSFIDLGYSTVIIPKMLVNFVTEKNVISYPGCMTQLYCFIAFVLCECYMLSAMAFDRYVAICNPLRYNVTMSYQVCFWMIGGVYSIGFIEATIHTVCMLQVFFCKANVVNHFFCDLLPLFQLACSSTFVNETVLLCLSTLNFCVPTLTILSSYSFIIARIIRIKSTESRFKAFSTCSSHFSSVAVFFGSLGFVYFQPSSVSSKDQGKVSSVFYTIIVPMLNPLIYSLRNKDVKLALNKLFQKKIFHM", "length": 312 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2K381-1", "protein_name": "Killer cell lectin-like receptor, subfamily A, member 4", "gene_name": "Klra4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEQEVTYSTLRFHNSSGLQNQVKTNETQGPRETGHRGCSVSWHLIMIPLGILCSILLVTVAVLVTHIFQYSQEKHELQEALNKLHHNYSTMQNESYLNEEMLGNKSSECDAYKSVLDSLNRQQNTCLRLTNIVLDCLQHKGRQVNVHLFCCGIKCYYFIMDKKQWKECEQACQGCKLSLLTIDDEDELKFLQLQVTPDSYWIGLSYDNKKHDSAWIDNNPSKL", "length": 224 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2K3S0-1", "protein_name": "Olfactory receptor", "gene_name": "Or4c109", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYNQSFVNEFILLGLSQNPQIKKISFVIFLLVYIATLVGNMMIVVTIAYSPALLGSPMYFFLAVLSFLDACVSSVVTPKMIVDMVYERKSISFECCMTQVFAVHFLTAVEVIVLAAMAYDRYVAICKPLHYSSIMNRRLCGTLVGVAWAGGFLHSIIQIAFTLPLPFCGPNVIDHFICDLFPLLKLACTDTHIFIILVFANSGSICIIIFSFLLISYGVILFALRAHSSEGRRKALSTCGSHITVVVFFFVPCILIYARPTSAFSFEKNVFVFTDVLTPLLNPMVYTFRNKEMINAIRKMWKRLIVVSDKY", "length": 311 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2K622-1", "protein_name": "Histone RNA hairpin-binding protein", "gene_name": "Slbpl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLSSRMEMVSVGVTTEPCHARWEVETDEVVLRRRQKQIDYGKCTPGYQSFLQQVPRAQRQPGFHPQTPNKNRRYSRRSWDAQIRQWRRALHTWDPPSQPLHDRQAEGKAAGNFLRPVDTAPLDDLLDNWPQDPESSENWDRGEKEAQFAYLKVPASCPPQLKDELLHH", "length": 169 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2K698-1", "protein_name": "Lamin tail domain containing 1", "gene_name": "Lmntd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSHLASSHRVQKSSLARPERRAKSPSYTDISFWVPVMHRVGSQYQFESVCEQSSGYPGMPAQQVTPVPSQRGGILRKEEKTGTITPSKQHSSVHFFPKVMDSSSTLHLLSGSFSHEASANFHQIPSAQDSLSPGGLLTSKSNVPSCSRKDSIPGKQSTHQAASPGTSLMTLKKQPKPSSDLDTYVLGDGEDYFLSLFGDSKKLTSHTSQAEDVSKHLSVILEEVGQFVSSSLGDIKIAEVNVKGFFVRLVNSSNEKEVEIGNYILQQNVNGQAVSLYRFPHNITMQASGTVTVWAAASEAKPQQPTDFVWEEQSRFRSSPDCTTILCKPSGEAIAWYTPIHWKQAWEKLETDIEFERCSVVIPSLKSHIFGRTTSSVSSINKEKQEPTQKTPPQVCSVLLREKEILLTVLPNKSPWCRSPDTPPHPYSSLIEWHDSDFPGSSLGTQPKPQSTKPKPDPGTKEKKSTR", "length": 467 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2K6E6-1", "protein_name": "Rho GTPase-activating protein 20-like", "gene_name": "LOC120093152", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGEIHRTLLCQGPVELTSGRKRNKRYLSLFDDVLVVSTNLTKKKFKIKCIIPLNYLWVVDDEELVRANKTCTCKTIFFYWATGNALATFRSEEQKVQWYTFLTSRSISEAKKGIKKTFPLHIFPEDIQTCDSSLCVTATNMDTVNDIMEKLLPMIRVHKIEDYQLWFSPGHKEAPRALQGHEYPYDIIMNNVQNNLSKSNSKIFTAFPPLPGLFMENQSWDTGGQFILKPRDSAGSQQQDAKERRRKSCMTSCFHGGCVPHHDQECSDPRDDKRGKLFGQDLSSICQDGKLPTIILDMLSRIKDKGPTTDDIFLITPNGSLCKTIKEKLDNGENVDIYQQPVHVVAWILKEFLQSIKGSLLTSKLYDQWLIVPEKVNDKEKLAAVKSLLEKLPKPNADLLRQLFRILHQIKTKSSVNNMSSFRLSLETAPCILWLPSYRNNILTNDIAKKISLVTFMIDNSPELFGEDIVAVWYETSLYHPPGLKYPCSQNTPSSNGIMEETEHGLSSCPGERTCTPDFDELPRSGAVASIPYEGILASEKGEGNESTTQPEPVQNSPTPQTKKELGNCSPNILKDVNVPAVILDMLSVIAEKGQCSDDIFRMQAEKSHWSLKEKVNTGKHVNLKEESVLTVASVVKDFIKNIEGSLLSCDLYENWLSIPDEGPLLGKIASIQNILLKMPKPNYVLLKQLICVLQKIKAASTNQLDTFDLSVRIAPHVLWNPTCKMFYGRDLSKKLSIIQFMIDNCQELFGENDNIFCEDNQKSYDINLSSDTLNTSGKATLMIETIDDHDVKTSKANTKELEMSSAVPHEGGPTAGHNGTTSKYNVPQEIILHD", "length": 835 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2K6V9-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "Smokwl2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDITSIKKTLGSQYRVVFFLGQGSYGRVRLAWHRRTQALVAIKTVEISKDTIRGILSEMTTLESLNHPNIISLYEVLITGTGVHFILQYAPGGNLGKLISEEGPLPEEKAKKMFGQVVSAIRYCHSLDIVHRDIKPQNILIDGEGNIKLIDFGQAIKCKPGTLLSRHCGTRDFNAPELVLREPYDGKSSDVWSLGVVLYFFTTGYLPFRGKTINDVEERITTGTYTIPTHLSGQLENLIHQILRVSPDMRPSVEEIENHPWIKKCEFKILPKTDPDYKIIEMLCAMGYKAKDILESLQKKRYDEPMGAYLSLKDHVSKGFDVGYITPAKPGDPCPPPPPSPAHPSVFGLPLRRRASEPIFGLHHRPPSREQNPLDLILSGLKMSRCVSMPPIAVYYPKKERSTSTRALHSTPVACPCVSNNMSEVEIILPPKQDIEMNTSSPPQRMGWFKRLRKGIRDCFSRLCCLPRAPKKKTQHRSSKRVAPLKKAASSTI", "length": 493 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2K894-1", "protein_name": "Olfactory receptor", "gene_name": "Or4x6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAHLLNVTEFIFLGLSPNKEGQRVCFVLFLLLYMAIVLGNLLMVVTVAASRNLGSPMYFFLSFLSFVEICYSSTTAPKLIFDLLAEKKSISVWGCMTQLFFMHFFGGTEIFLLTMMAYDRYVAICKPLHYTSIMNQQVCAVLVGSAWIGGFVHSFSQILLILPLSFCGPNVIDHYFCDLLPVLKLACSDTFLIGLLIVVNGGTLSVISFVVLLASYLVILFHLRTQSAEGRRKALSTCGSHVTVVILFFGPCVFIYSRPSDTLPVDKMIAVFYTVITPLLNPLIYSLRNAEVKKAMKNLWFRIMKADEK", "length": 309 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2KB39-1", "protein_name": "Myb/SANT DNA binding domain containing 5 like 1", "gene_name": "Msantd5l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQREANQGESLENTEESNVGKSVKEEEQRPSGRSRSSWTDSEIRVFLQEWEVVEQEMGQPGRKLHKKTKSLCQRLYQQGLKKSWKSCFHLLLSLQDLHRTLCNERPGIEPLFSPYSEALYRILGSTPHESWFPGPLYDEADDSMLPVYPQPPMYQPSDYGITVPSAQLQGNPVPMMCQEDSPFPTWEPWNPSYPLSVPHLLPGFAPGDPSLQQPWSMCDLHQDPQ", "length": 225 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2KBC9-1", "protein_name": "Leukocyte immunoglobulin-like receptor subfamily B member 3-like", "gene_name": "Lilrb3l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTFTFTALLCLGLTLRLWIPVLTGSLPKPILRVQPDSVVSMGTKVTFVCEETIGVKESHLYRNGNLQRTVLKNHQKPTNKTEFSFSNVDQQMQQYQCSYRTQTKSSDYSEPLELVVTGAYSKPSLSAQTNPVVTSGGYVTLKCEPSQDNHTLILTVEGSQKHSWRKDPECNRYTEKCHALFYVGPLTSNQRWIFRCYSYEKHTPQVWSAPSEPVELLVSGKLQKTTIKAEPGSVIRSGRAMTIWCQGDLDAEIYFLHKEGSHNTQSTQTLQQPGNKAKFLIPSVTQRHAGQYRCYCYSSAGWSEPSDTLELVVTGIYYYGVKLSGLPSPVVPEGGNVTLHCTSHSNYDKFILTKEDQKFTSSLDAEYIPSTGQHQALFVMGPMTPNYSGTFRCYGYYKHTPQLWSVPSELLKIFISGPSRKPSLLSHQGHILEPGMSLTLQCYSDTKYDKFALYKEGGTDIIESFSQWTKAGLSMTNFTLSVMPNSTVHSGENVTLMCWSTYSVDTFILSKEGSGQPPLRLKSKIQDQQYQSEFSMSGVTSKLSGTYRCYGSHDSSLYLKALIGVSVAFLLFLFILIFILLRRRHQEKFRKDDEDAQKGKELQLSTGAAEPVTRDRGHQKRSNPAAATQEESLYASVEDMETKDGVELDTWKPPEGDPQGETYAQVEPSRLRRAGAISPVVSREQLNTKYEQAEEGQEVDSQATESEEPQDVTYAQLCSRTLRQGTAAPPLSQAGEAPEEPSVYAALATARPGAVPKNKKQ", "length": 761 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A0G2KIH5-1", "protein_name": "Major histocompatibility complex class I LLA precursor", "gene_name": "mhc1lla", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTGKVLFVLFLLSAPTTVLTDSHSLWLLGTYIKGETQFPKLSFTVMLDDLRVGFYNSETKEFIPRDNTTNEDEAVSDVLTVIQNTLEPFMMSTLTFKNGTESPQLFQITWHCELLDNDKPGQIIFKIAFSGSTTDEVSFYNDNFTCQCQNNMATVPLESFQMHYETVCYPNCIATIRDYLKKRQTQVNGKVQPKVRLIKKVHPKSGGFRLSCLATEFYPHSINLTLLRDGQPVSDHEVTGGNLLPNGDGTYQMRKSLEIRADEREKHKYTCSVSHLSLDKILDIDFEFDPSFLIKIVIPVVVLLSLMLVLTAVLIHKCKNKRAESKETITTASTPEPTEMSETLRK", "length": 346 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A0R4IEQ0-1", "protein_name": "Guanine nucleotide-binding protein subunit alpha", "gene_name": "gna11a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTLESMMACCMSEEAKESKRINAEIDKQLRRDKRDARRELKLLLLGESGKSTFIKQMRIIHGTGYTDEDKRGYTKLVYQNIFTSMQAMIRATEHLKIPFRFEDNKKNALLVREVDVEKVCSFEQPYVAAINKLWMDPGIQEAYDRRREYQLSDSTKYYLNDLERISSRGYMPTQQDVLRVRVPTTGIIEYPFDLENIIFSYLSDLERISDPSYLPTQQDVLRVRIPTTGIIEYPFDLQSIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKILCSHLVDYFPEFDGPQNDAQSAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQHNLKEYNLV", "length": 400 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A0R4ILG2-1", "protein_name": "FXYD domain-containing ion transport regulator", "gene_name": "fxyd2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGVESPEHSDADFTYDYELIRRGGLIFAAVLFCLGMVIIFSKKLRCGKSSATHEDNGDL", "length": 59 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A0R4IU63-1", "protein_name": "Metabotropic glutamate receptor 5", "gene_name": "grm1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRMLILRMNFFIVFLLFCTRLHLSTERSAVSRAASRSVARMDGDIIIGALFSVHHQPSAEKVAERKCGEIREQYGIQRVEAMFYTLDRINSDPYLLPNITLGCEIRDSCWHSSVALEQSIEFIRDSLISIRDEREGPKWCVEGNPSAQPPATKKPIAGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARALLDIVKRYNWTYVSAVHTEGNYGESGMEAFKELASQEGLCIAHSDKIYSNAGEKHFDRLLRKLRERLPKARVVVCFCEGMTVRGLLMAMRRLGVAGEFLLIGSDGWADRDEVVEGYEEEAVGGITVKLQTEEVTSFNDYFLKLRLATNNRNPWFAEFWQHRFQCRLAGHPQENTNYRKNCSGYESLEDNYVQDSKMGFVINAIYAMAHGLHDMHEHLCPGHVGLCEEMDPIDGSKLLDFLLKTSFAGVSGEDVWFDENGDSPGRYDIMNLQYVEPGVFDYINVGSWHEGILSIDDYMIQMNRSEMVRSVCSEPCSKGEIKVIRKGEVSCCWICTPCKDNEYVQDEFTCKACELGWWPDEELQVCEPLPLRYLEWSHPESIAAVVFSCLGILVTSFVTLVFILYRDTPVVKSSSRELCYIILAGIFLGYICPFTLIARPSIASCYLQRLLVGLSASMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVVIAFILISMQLTLEVTLIILEPPEPIKSYPSIREVFLICNTSNMGMVAPLGYNGLLILSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTSFSVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKIACRSNSLLNMFKRKKNASGNANSNGKSVSWSEPGSRHPPKGEHMWHRLSVHVKKQEAGSNQTAIIKPLTNTYNNPGMEFSDLSTKTLYNVAEEDEIDPIRYNPSNSPHLMAPVSKPMKEVGANLTFYTPEQHVPQQNSVLPQHAMIEHFQDDVVKYNSNMADLDEIISLPEPTDGIILALQPQVLHPHPILPMNVYQDEPSSPLEEVENEQFGLLHGYMYDNAQIHDEEELVQIKMAMEDSMALMPPSPFRDSLGSGSPVRNSPVSESVLCTPPSVTYASVILRDYKQSSSTL", "length": 1158 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A0R4IUN8-1", "protein_name": "Trypsin inhibitor ClTI-1-like precursor", "gene_name": "spink2.9", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLAQIVLLLCLSVMATAADKCPSVPNCSRYHPHACTMEYWPVCGSDGNTYGNECELCATIFEEKLNIILISKKGEC", "length": 76 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A0R4J2B9-1", "protein_name": "BTB domain containing 35, family member 23", "gene_name": "Btbd35f23", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEGIAGASYIPVSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFTNILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQKCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICNLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYNQEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A140T8Q5-1", "protein_name": "BTB domain containing 35, family member 21", "gene_name": "Btbd35f21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDMKLMYLLALSSDLLVMQKEIDVYTTLKIWMILYLNPCWNGTMKQLLQHANNWLSTHMAYIDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYNEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1B0GQX3-1", "protein_name": "Cortexin domain containing 2", "gene_name": "Ctxnd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCVLMEDSSMSNGIDVDKGFAIAFVVLVFVFLIVMVFRCVKLVKNPYEVSSTTADLPLN", "length": 59 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1B0GRH6-1", "protein_name": "Zinc finger and SCAN domain containing 4, pseudogene 3", "gene_name": "Zscan4-ps3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASQQAPAKDLQTNNLEFTPTDSSGVQWAEDISNSPSAQLNFSPSNNGCWATQELQSLWKMFNSWLQPEKQTKEQMISQLVLEQFLLTGHCKDKYALTEKWKASGSDMRRFMESLTDECLKPPVMVHVSMQGQEALFSENMPLKEVIKLLKQQQYATRPTPDNEQMPVDTTQDRLLATGQENSENECNNSCNATEANVGESCSGNEMDSLLIIQKEQHPEHEEGNVVRQFPHGARRASQGTPSHHVDIQSPPTTADVTMEEQPKDLSRENISEDKNNCYNTSRNAATQVYSGDNIPRNKSDSLFINKRIYHPEPEVGDIPYGFPQDSTRASQGTSTCLQESLGECFSEKDPREVPGLQSRQEQLISDPVLLGKNHEANLPCKSHQKRFCRDAKLYKCEECSRMFKHARSLSSHQKTHLNKKSELLCVTCQKMFKRVSDRRTHEIIHMPEKPFKCSTCEKSFSHKTNLKSHEMIHTGEMPYVCSLCSRRFRQSSTYHRHLRNYHRSD", "length": 506 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1B0GS00-1", "protein_name": "Predicted gene, 36210", "gene_name": "Gm36210", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHPGSPAAPGVSEPGPRELCAFVSGASAHMLRALQPRRIRPSKRRPNHRRFLHNQICREFAKIEAATQHLALTILSQKAPAQRPPFRRPPPPPPSPFLGVACAEAPMEAPHGSPSLSPVALDTSTLDLFDDILLTPTPRPLVTPDSFCQTLPAGNPQVASDVISHALGPGDQGQPTPIQAPRFSNLLLPPQKAQGGSLEPAALGCGWVDSWEAPYACDPQGVLDSWGAL", "length": 229 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1B0GSB3-1", "protein_name": "Family with sequence similarity 236, member D", "gene_name": "Fam236d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIVMHLVGHPQLTGTEGVATEGVATAHTMLTSRGPRDTREPAPPTRSWRSRFQRALARVSKFFRRGRRTARG", "length": 72 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1B0GSI2-1", "protein_name": "Family with sequence similarity 236, member C", "gene_name": "Fam236c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIVMHLVGHPQLTGTEGVATAHTKENSSRGPRETREPAPCTRSWRSRFQRAVARVSKFFRRRRRST", "length": 66 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1C7CYU6-1", "protein_name": "Zinc finger and SCAN domain containing 4, pseudogene 2", "gene_name": "Zscan4-ps2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASQQAPAKDLQTNNLEFTPTDSSGVQWAEDISNSPSAQLNFSPSNNGCWATQELQSLWKMFNSWLQPEKQTKEQMISQLVLEQFLLTGHCKDKYALTEKWKASGSDMRRFMESLTDECLKPPVMVHVSMQGQEALFSENMPLKEVIKLLKQQQYATRPTPDNEQMPVDTTQDRLLATGQENSENECNNSCNATEGNVGESCSGNEMDSLLIIQKEQHPEHEEGNVVCQFPHGARRASQGTPSHHVDFPSVPTTADVPMEEQPKDLSRENISEDKNNCYNTSRNAATQVYSGDNIPRNKSDSLFINKRIYHPEPEVGDIPYGVPQDSTRASQGTSTCLQESLGECFSEKDPREVPGLQSRQEQLISDPVLLGKNHEANLPCESHQKRFCRDAKLYKCEECSRMFKHARSLSSHQRTHLNKKSELLCVTCQKMFKRVSDRRTHEIIHMPEKPFKCSTCEKSFSHKTNLKSHEMIHTGEMPYVCSLCSRRFRQSSTYHRHLRNYHRSD", "length": 506 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1C7CYV3-1", "protein_name": "Zinc finger and SCAN domain containing 4, pseudogene 1", "gene_name": "Zscan4-ps1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASQQAPAKDLQTNNLEFTPTDSSGVQWAEDISNSPSAQLNFSPSNNGCWAIQELQSLWKMFNSWLQPEKQTKEQMISQLVLEQFLLTGHCKDKYTLTEKWKASGSDMRRFMESLTDECLKPPVMVHVSMQGQEALFSENMPLKEVIKLLKQQQSATRPTPDNEQMPVDTTQDRLLATGQENSENECNTSCNATEGNVGERCGGNEMDSLLIIQKEQHPEHEEGNVVCRFPHGARRASQGNSSHHVDFRSALTPADVPMEEQPKDLSRENISEDKNNCYNTSRNAATQVYSSDNIPRKKTDSLSINKRIYHPEPEVGDIPYGVPHDSTRASQGTSTCLQESLGECFSEKDPREVPGLESRQEEPISDPVLLGKNHEANLPCESHHKRFRRDAKLYKCEECSRMFKHARSLSSHQRTHLNKKSELLCFTCQKMFKRVSDRRTHEIIHMPEKPFKCSTCEKSFSHKTNLKSHEMIHTGEMPYVCSLCSRRFRQSSTYHRHLRNYHRSD", "length": 506 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1D5P3Y4-1", "protein_name": "Large ribosomal subunit protein uL24m", "gene_name": "MRPL24", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRLSALLRLAAPPKLPKGYRHGTWRPGTAAERLRNPPGQRRKKIFVEPISREDWKVFRGDTVQVLTGKDAGKQGMVTQVVRARNWVVVEGLNTHYRYVNRDAKYSSTYIASEAPLLLNQISLVDPEDRKPTEVDWRYTEEGERVRVSLRTGRIIPLPLWQRRDGIVPEQWIDGPKDTSVDDALDKTYTPSLKTFEEEIMDAMGIVETRRAKKSYWY", "length": 216 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A1D5PNZ8-1", "protein_name": "ODF3A protein", "gene_name": "LOC124417034", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPASMDGAWVGTWRPHRPRGLISAQFPSPGPQYSIPGTTGYVGHSPTKARAPAYTFRGTKPPAAGSCGPGPCYFVEPAITRNGKYVAPGAQLRGRPATKTTVTPGPSDYRTEAANRHVFKCPPVQSMAFRREPLRTDHPPGPGTYTLPRLMGPNTVYTSASPCYSVRGRSQRGRFDEDLAKTPGPAALPKVPVDAYKTRAPAYTMAARPKAGEGKAAKPGPADYSVGRVTLIKPQAPASTFGIRHSLYTTPLIVE", "length": 255 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A1D5RLF0-1", "protein_name": "F-box and WD-40 domain protein 27", "gene_name": "Fbxw27", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METHLPSLPLMKIFSYLDAYSLLQVAQVNKNWNALASSDVLWRKLCQKRWLFCDMVTLQLQDKETWKQFFVYRTWQEHSKTRANPRDFTYKEIPLQYGPCGYACYISGCGITRKGQDKSVVCMVNSKNTISTWDVHKSVITWVSPEQPASIKLLTTLPEMHIAVTVDIQSTIKLWDCHNREALATNILESPCKSLKAVITKDDPIVLVSDILGNLYIFRIPDLHLISTVNVLPCDIDEIYCSPQKKWVLLSKKQPYILPKVFYMSSLLRTSEFSAPVSTLLEISLCQEAFWTPRREDRLTLMSRSGCSKITKFETYDMKLEEFGNKIIVKGNSIAGFLLPYYTESLNWFGVSDKDTIVCSTEFSLLLFTNNGHRLQTFQYFSETIVRLSVDPVHVIVTCNDGSLDVYAWEERSLLLRKCYRLKNRRHLSPRGFINKTLCDDVSIIQLMIDGHDTWFLMAYALNICS", "length": 466 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1P8ASP4-1", "protein_name": "Serine/threonine-protein kinase PRP4 homolog", "gene_name": "PRP4KB", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVSDKHVESNHRKHRRSFSPSDEVFKSPKRHKSRHHHRRHGHRHHRDEEVQYNDDENVNGGDLDMEEGEILGKEGIGETLKKKLESVDEFGDIKSGQFRENNLAFNGDDGFPLICKSWIRVYNYLSYKCHGRNQRRERECEKRKEIEPDRERRKERGSVDRDSRGDREKDYLRDRDNDRGRSRDKARYSSRERGRENERERRSEKDRDKGREFQSDREKHKSLDDGYGEVRHKHSGHSRHDAEDDLELRSPTSVNGHDPNSGDVKETRGNVERTRIDNDDKGDVVVWEVEQEDEELNLIEESRRRTQAIMEKYKKKLEQQNGFSSHDLELANIPKQSSTVADVLGSGTLGPVTSAVNQAKAGLDIDAVDGEVAKLSSAVGESPAQLVISDSDRTLASTGLGEGSPKDKISDDMFTDDIFGESPADSQKMVCTLTQIIDLVFIEFSNSGFICFVFPVHHLTRYSRNGLPFVHYIFVGYLRGKGNGIPIVRSGLDDNWDDAEGYYSYQLGELLDDRYEIMATHGKGVFSTVVRAKDTKAELGEPEEVAIKIIRNNETMHKAGQTEIQILKKLAGSDPENKRHCVRFLSTFKYRNHLCLVFESLHLNLREIVKKYGRNIGIQLSGVRVYATQLFISLKHLKNCGVLHCDIKPDNMLVNEGRNTLKLCDFGSAMFAGTNEVTPYLVSRFYRAPEIILGLPYDHPLDIWSVGCCLYELFSGKIMFPGSTNNEMLRLHMELKGAFPKKMLRKGAFIDQHFDKDLCFYATEEDSVTRKTTKRMMVNIKPKEFGSVIKQRYKDEDSKLLVHFRDLLDRIFILDPQKRITVSQALAHPFITGK", "length": 834 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "A0A1P8BFV1-1", "protein_name": "Bax inhibitor-1 family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDGLKDFSRISPAIQSHLMRVYFSLFCILAASAFGAYLHMRLNIGGTITKLGWVLSLLEHVVSCPPYKHKIRFSLLLLFGVLHGASVGPCIKSTIDIDSSILITAFLGTAVIFFCFSAVAMLARRREYIYLGGLLSSGFSLLTWLKNSDQFASATVEIQMYLGLLLFVGCIVVNTQEIIEKAHCGDMDYAVHSLILYIGFVRVFLQILSIMWNTSADRIRRNNEET", "length": 226 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "A0A1W2P6Q8-1", "protein_name": "Cell division cycle 5-like protein", "gene_name": "Cdc5lrt6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDRTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKTDKQRLKRKKESDLPSAILQTSGVSELTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAPQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPLRTPSNGAEGLTPRSGTTPKPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGFLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEVKRMHKAVQKDLPRPSEVNETILRPFNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGLATNDSEHITYLEHSPYEKFSKEDLKKAQGALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLSLIAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKREDSAIPRRLECLKEDVQLQQEREKELQQRYADLLMEKETLQAKF", "length": 802 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1W2P7S8-1", "protein_name": "Cell division cycle 5-like protein", "gene_name": "Cdc5lrt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKMRQQDLDGELRSEKEGRDRKTDKQRLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAPQDRILQEAQNLMALTNVDTPLIGGLNTPLHESDFSGVTPQQQVVQTPNTVLSTPLRTPSNGAEGLTPRSGTTPKPVTNATPGRTPLRDKLHINPEDGMADHSDPSYVKQMERESREHLRLGFLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQATRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPFDVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGFATNDSEHITYLEHSPYEKFSKEDLKKAQDALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPAQSCYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLEEDVQRQQEREKELQQRYADLLMEKETLQAKF", "length": 802 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1W2P7Z8-1", "protein_name": "Cell division cycle 5-like protein", "gene_name": "Cdc5lrt7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDRTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKTDKQRLKRKKESDLPSAILQTSGVSELTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAPQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGFLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEVKRMHKAVQKDLPRPSEVNETILRPFNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGLATNDSEHITYLEHSPYEKFSKEDLKKAQGALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLSLIAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKREDSAIPRRLECLKEDVQLQQEREKELQQRYADLLMEKETLQAKF", "length": 802 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1W2P855-1", "protein_name": "Cell division cycle 5-like protein", "gene_name": "Cdc5lrt8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRIMIKGGVWRNTEDEILKAAIMKYRKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDRTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKTDKQRLKRKKESDLPSAILQTSGVSELTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPAPQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPLRTPSNGAEGLTPRSGTTPKPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGFLGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEVKRMHKAVQKDLPRPSEVNETILRPFNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGLATNDSEHITYLEHSPYEKFSKEDLKKAQGALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLSLIAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKREDSAIPRRLECLKEDVQLQQEREKELQQRYADLLMEKETLQAKF", "length": 802 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1W2PP81-1", "protein_name": "TATA-box-binding protein-associated factor 11-like protein 5", "gene_name": "TAF11L5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METGRQTGVSAEMLAMPRGLKGSKKDGIPEDLDGNLEAPRDQEGELRSEDVMDLTEGDSEASASAPPAAKRRKTHTKGKKESKPTVDAEEAQRMTTLLSAMSEEQLSRYEVCRRSAFPRARVAGLMRAITGSSVSENAAIAMAGIAKLFVGEVVEEALDVCEMWGETPPLQPKHLREAVRRLKPKGLFPNSNCKRIMF", "length": 198 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A1Y7VLT7-1", "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKNKGKGGKNRRRGKNENESEKRELVFKEYGQEYAQVTKMLGCGWLEAMCFDGVRRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNQDEARSLKAYGELPEHAKINEMDTFGPGDDDEIVFDDIGEDDEDIDDI", "length": 144 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A1Y7VNG9-1", "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKNKGKGGKNRHRGKNENESEKRELVFKEYGQEYAQVTKMLGCLWLEAMCFDGVKRLCHIRGKLRKKVWISTSDIILIGLRDYQDNKADVILKYNPDEARSLKAYGELPEHAKINETDTFGPGDDDEIVFDDIGDDDEDIDDI", "length": 144 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A286YCH8-1", "protein_name": "Predicted gene, 47985", "gene_name": "Gm47985", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALGAELSETLVEKPEHMNLEMSILAPSKRKQLLDKKAEDKQPPESRGNNGRSSKSSPMGKDNTWPSPEAKVPSQKRSGQSWAVSSCGPHKRSSKLEDKRRNRPSRFRERGRDKPGSTHKRDSSHTKLHVKDRRSQPRSPVRTLKRSRSGDRQGAPHNSAKRHRQTSPPEASSLPTFSLLMSRVFTNVDALQVSLDDLQAPGGAFLRVPSSSTEPIVLQRAWLTWQLSHAGAALHWALHTVKSILTSQASLPRYTWPQGYSFTADPRPVPTSKIQASQLAQRPGDLASPNPSVDTRSILG", "length": 300 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A286YD13-1", "protein_name": "Predicted gene 8947", "gene_name": "Gm8947", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALGAELSETLVEKPEHMNLEMSILAPSKREQLLDKKAEDKQPPESRCNNGRSSKSSPMGKENTWPSREAKVPSQKRSGQSWAVSSCGPHKRSSKLEDKRRNRPSRFRERGRDKPGSTHKRDSSHTKLHVKDQRSQPRSPVRTLKRSRSGDRQGAPHNYAKRRRQTFPPEASCSLPTFSLLMSRVFTNVDALQVSLDDLQAPGGAFLRVPSSSTEPSVSQRAWLTWQLSHAGAALHWALHTVNSILTAQASLPRYIWPQGYSFTADPRPVPTSKIQASQLAQRPGDLASPNPSVDTRSILG", "length": 301 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A286YE43-1", "protein_name": "Predicted gene, 47996", "gene_name": "Gm47996", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALGAELSETLVEKPEHMNLEMSILAPSKRKQLLDKKAEDKQPPESRGNNGRSSKSSPMGKDNTWPSPEAKVPSQKRSGQSWAVSSCGPHKRSSKLEDKRRNRPSRFRERGRDKPGSTHKRDSSHTKLHVKDRRSQPRSPVRTLKRSRSGDRQGVPHNSAKRCRQTSPPEASSLPTFSLLMSRVFTNVDALQVSLDDLQAPGGAFLRVPSSSTEPSVSQRAWLTWQLSHAGAALHWALHTVNSILTAQASLPRYTWPQGYSFTADPRPVPTSKIQASQLAQRPGDLASPNPSVDTRSILG", "length": 300 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A286ZIN6-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "LOC110258935", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MANLTSMSGFLLMGFSDDHKLQILHALLFLVIYLLALTGHLLIITITTLDHHLHSPMYYFLKHLSLLDLCFISVTVPQSIANSLMNNGYISLGQCILQVFFFIALASSEVAILTVMSYDRYVATCQPLQYETIMDPWACRQAVIAVWVTGGLSGLTHTAINLSVPLCGDRVIHQFFCDVPQMLKLACSYEFINEIAVAAFTTSTAFFCLISILLSYTRIFSAVLRIPSAQGRTKVFSTCLPHLLVVTFFLSAAGFEFLRPPSDSQSAMDFMFSIFYTVVPLTLNPVIYSLRNKAMKAALRKVLSKEEFAQRKKYFKALFQL", "length": 321 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZIP8-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110259124", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "QEYKANGGDNTTTIIHFVLLGFSDFPHIRPALFVVFLVIYILTLTWNLCLIVLIRLDSHLHTPMYFFLSNLSFIDICYVSSTAPKMLYDFFQAKPTITVVGCAIQYFVCSTMGLSECCLMTVMAYDRYAAICNPLLYSSIMSPSLCGRMVLGSYMAGLSATLSQVCAVLQLHFCGPNVIHHFFCDMPLMLGLSCSDTFFVQVLTAIFTVFFGIINALVIMMSYVYIVISVMKITSAKGRSKAFNTCASHLTAVTLFYTSGIFVYLSSSSGGSSGLDRFAAVFYTVVIPMLNPLIYSLRNKDIKDALKRLKKRKECC", "length": 316 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZLI4-1", "protein_name": "C-C motif chemokine ligand 24", "gene_name": "CCL24", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFSPSSLIKASGQLQCPAGNRLLAPTLSSCIAALSPELPLLLSRHGRPVTVAASLLFLGLCAYSFAPADSVTMPSSCCIYFISKKIPESRVASYQLSNSSVCPQAGVIFTTRKGQKFCGDPKQLWVQKYMKKLDAKRKKASTRIRAMGTGAPVRRGPANSTSI", "length": 163 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZSE3-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258059", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRNRTITTFILLGLTDDPKLQVLIFIFLFVAYMLSLTGNLTIITLTFVDSHLKTPMYFFLKNFSFLEISFISSCIPRYLYSIATGDKVITYNACVIQVCFTDLCGVTEFFLLAAMSYDRYVAICKPLHYVTIMSSRVCGILISSCWMAGLCVLIPPLSLGLNLKFCDSNRLDHFGCDAFPLVKISCSDTWPMEQTVIICAVLTLNMTLTCVVLSYAYIIKTIFRFPSVQQRKKAFSTCSSHMIVVSITYGTCIFIYMNPTAKGEVTIKKVVSLLIFSVSPTLNPFIYTLRNNQVKRAFKDSIKRIALLSTR", "length": 311 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZU87-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "LOC100152920", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGENQTVLFEFIILGFSNLKELQFLLFTIFLVTYICTLGGNSFIILETMTNLHLHTPMYFFLENLAFLDICYTTTNVPQMMAHLLSEKKSISYLGCMAQLFAFIFFVGSESLLLAAMAYDHYIAICKPLRYSVIMNKVLYSQLAASCWSGGFLNSTVHTVLTFRLPFCGNNQINYFFCDIPPLLVLSCGDTSVNELALLSIGVVIGWTPFLCIVLSYLYIISTILRIRSSKGRQKAFSTCASHLTIVLLYYGSAIFTYGRPISTYSLEKDRLISVLYSIVTPMLNPIIYSWRNKDIQEAMQVMGRKWKASSSLSFDV", "length": 318 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZVC9-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258401", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGQRNSTSLHDFILLGFSDHPKLEMALSGVVATFYLITLVGNTAIILASLLDSHLHTPMYFFLRNLSFLDLCFTTSIVPQMLVNLWGPHKTISYGGCVIQLYVYMWLGSIECLLLAVMSYDRFTAICKPLHYLVIMNPHLCLKMIIMVWSISLANSVVLCTLTLNLPRCGNNLLDHFLCELPAMLKIACIDTTAVELSVFALGIAIVLTPLILILISYGYIAKAVLRMKSRAGQRKAINTCGSHLTVVSIFYGAIIYMYLQPGNNASRGQVIFLTLFYTIITPSLNPLIYTLRNKDMKEALKKLMRVDHKSTKSKRTWKS", "length": 320 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZWC4-1", "protein_name": "Zinc finger protein 16", "gene_name": "ZNF16", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLPLSQVPAMPSLRTRPGKAEMEPSVPGPSLRTPGTQVSVSDAPAVTHPGSALHGPLSCGDTEPGATPPHHQLADWDLRTEGSQLLQKEDASEDLESQAGTSEDYVGAGSQAPERGELCADVLGSDWGVPQGERLSLCQEGGFMPAYLLPGSPLEEPEIDTEPLERNFGLIITPVASPGEPEEETPQPFDACDQSVHCGVDLAGHEGLHAAESSFICGECGESVGLHSDLLRHRLSHRGEKPHVCAECGEAFSQSASLESHQRSHEPAKPFQCSTCGKAFGRSSSLIKHHKVHTRERPHACGECGRPFSRFSNLVKHRRVHTGEKPYRCSECGKAFSQSSSLLQHRRVHTGEKPHVCPVCGKAFSYSSVLRKHQIIHTGVKPYSCSACGKAFSHSSALIQHQGVHSGDKPYECRECGKTFGRSSNLILHQRVHTGEKPYECAECGKTFSQSSTLIQHQRIHNGLKPHECDQCGKAFNRSSNLIHHQKVHTGEKPYTCVECGKGFSQSSHLIQHQIIHTGERPYKCGECGKAFSQRSVLTQHQRVHTGEKPYDCEACGKAFSQRSKLVKHQLIHARE", "length": 576 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZX75-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100156955", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "IFIMEWENQTASSDFILMGIFSHTPTHIFLFSLVLGIFTVALLANTVMVLLICLDRRLHTPMYFLLSQLSLMDLMLICTTVPKMARNYLSGRKSISVAGCETQIFFSVSLFGAECFLLAVMAYDRYAAICYPLQYPQLMNWNVCGLLAASSWILGVFDGIVDIAATLSFSYCGSREIPQFFCDITALLRLSCTDTSTFETLVFICCVVMLLFPLSLIIISYTRVIITVIRMSSGEGRHKAFTTCSSHLVVVGMYYGAAMFIYMRPTSNRSPAQDKMVSAFYTILTPMLNPLIYSLRNKDVAKAFSRCWGREI", "length": 312 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZY56-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258501", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "METDNDTQILEFLLLGFSKQPESQPIIFGLFCSMYLITVFGNLLIILAVISDYHLHIPMYFFLSKLSFVDICFTSTTIPKMLWNIQTQSKAITYEGCITQIYFLILFAVLDILLLTVMAYDRFVAICHPLHYTVIMNPRLCGLLVLVPWIMSVLNSLLQTLMMMQLSFCTNFEIPHFFCELNQMIQLACSDTFLNTIVMYFAAALLCGGPFFGILCSYSKIVSSIYRISSAQGKYKAFSTCASHLSVVSLFYCTMLGVYLSSAAAHSSHSSATASVMYTVITPMLNPFIYSLRNKDMKRALKALFVKGPM", "length": 310 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A286ZZP6-1", "protein_name": "HSF-type DNA-binding domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MANAPSEIQGVSPKDESTGSESSITSPWCDNSITGDLDLRSQIEEKAFQALSEGSLMKEPCHTLCASEPDGDNDFPPLPFPRKLWEIVESDRFKSIWWDENGTSIVINEERFKKEVLERKAPFRIFETESMKSLVRQLNLYGFTKLRRNFQRPASLANILAEDNEVSAWNKLQFYHNPNFKRGCPHLLVRMKRRVRVKNASPVSASVLQGCSKKRSRTGGDVDNHNSDVAAETRGEDAFSASTNLNVPLIRWPSMSQRISNTTTPTRSGLSSPSSPSFRPPGQIAMAQHAIFSQLTTFHMHSQSSYSPASGHIVNFITTTTSISQYRCISYFPSGYFGLRVEPSPLPTRYQNISPTEGPVSNPQPAAHPWFPMPMATDTSAASLSRPNPQSSSVSEHLPNYH", "length": 402 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287A7E2-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258743", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGQRNSTSLHDFILLGFSDHPKLEMALSGVVATFYLITLVGNTAIILASLLDSHLHTPMYFFLRNLSFPDLCFTTSIVPQMLVNLWGPHKTISYGGCVIQLYVYMWLGSIECLLLAVMSYDRFTAICKPLHYLVIMNPHLCLKMIIMVWSISLANSVVLCTLTLNLPRCGNNLLDHFLCELPAMLKVACIDTTAVELSVFALGIAIVLTPLILILISYGYIAKAVLRMKSRAGQRKAINTCGSHLTVVSIFYGAIIYMYLQPGNNASRGQVIFLTLFYTIITPSLNPLIYTLRNKDMKEALKKLMRVDHKSTKSKRTWKS", "length": 320 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287A7J9-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258750", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEQNNGTEVKEFILLGFAGQHKSWLVLFIVFLGIYVVTLVGNIGMILLIKIEASLHTPMYFFLQNLAFVDLCYATAITPKVLQNLMSTEKSISFIGCMVQLFVYGTFVTSDGYILAAMAVDRYVAICNPLRYPTVMSQRVCIQLLIGSCFMGFLNACVNGSLTFQLNFCKSNKINHFFCDAPPILALSCSSIYFNIMLLAAFVGFNLMFTVSIIIFSYIFILAAILKISSAAGRKKAFSTCGSHLTAVTIFHGTLSYMYLHHRTLESQEQEKLASVFYGIVIPMLNPLIYSLRNQDVREALKEIGKKML", "length": 309 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287A951-1", "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "LOC100514137", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVHMNVLTDALESINNSEKRGKRQVLTRLCFKVIVRFLTVMMKHGTPIGKFEIMDDPRARKIVVNLTGRLNKCGVISPRFDGQLKDLEKWQNKLLPSCQFGFIVLTTSAGIMHHEEAR", "length": 118 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287ACV2-1", "protein_name": "HSF-type DNA-binding domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAHAPSEIQGVSPKDAPTGSESSITSPWCDNSITGDLDLRSQIEEKAFQALSEGSLIKEPCHTLCASEPDGDNDFPPLPFPRKLWEIVESDRFKSIWWDENGTSIVINEERFKKEVLERKAPFRIFETESMKSLVRQLNLYGFTKLRRNFQRPASLANILAEDNEDSAWNKLQFYHNPNFKRGCPNLLVRMKRRVRVKNASPVSASLLQGCSKKRSRTGGDVDNHNSDVAAETRGEDAFSTSTNLNVPLIRWPSMSQRISNTTTPTRSGLSSPSSPSVRPPGQIVMAQHAIFSQLTTFHMHSQSSYSPASGHIVNFITTTTSISQYHRISNFPSGYFGLRVEPSPLPTRYQNISPTEGPVSNPQPAAHPWFPMPMATDTSVASLSRPNPQSSSISEHHPNYY", "length": 402 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AEV7-1", "protein_name": "Uncharacterized protein", "gene_name": "WFDC10AL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKWWGLQWLMLSCLAILPASGNWQERISASLEALTQSKLIPGMKPCKTIPTKEQCTYFCDLPRACPTGLLCCSASCGNVCMPPKGHGNRRSSHKISNFLFTAEPIKQQ", "length": 108 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AF12-1", "protein_name": "Large ribosomal subunit protein eL21", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTNTKGKRRGTRSMSSSPFRKHGVVPLATYMRIYKKGDIVDIKGMGTAQKGMPHKCYHGKTGRVYNVTQHAVGTVVNKQVKGTILAKRINVHIVHIKHSKRGDNFLKRVKENDQKKKEAKEKVTWVQLKHQTAPAREAHFVRTNGKEPELLEPNP", "length": 155 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AGK9-1", "protein_name": "DM domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDPDEMPTVPCCPLDSTTGLETGAPWGIEFGPRRAIRRCARCHNHGITDQIKDQEHLCLFQACECHKCVLFSEHCSILPAESALKTMQELHLKRQLTQGLIKSGTTSPKAHSHVKKSSIQTGVLSKLPRCSADRSGIGIFVSVLDSSTLEEATNNFTFQEVTQAPCPAQQAPKTSDQDSDSASLEWQRKLEAAEALLTLRESSQAPSGPTPLLQPSAAPAPAGERGLQPPSRSLRPRPASSISLPIGHVGCISLLS", "length": 256 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AKK8-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "LOC100155397", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDVRNHSIVSEFVFLGFTNSWEIQLLLFVFSFLFYSSSMMGNLVIVFTVTLDSHLHSPMYFLLANLPAIDMVFCSITAPKMIGNIFKKHKAISFCGCITQIFFTHAAGGTEMVLLIAMAFDRYVAKCRPHHYLTIINPRICLCFLVTSWIIGLIHSMAQLFFVVDLPFCDLNVLDSFYCDLPRLLRLACTDTQELQFMVTVNSGLLSMGSFVLLIISYIFILFTIWKHASGGSSKALSTLSAHITMVVLYFGPLIFFYTWPSPTSHLDKYLAIFDAFITPFLNPVIYTLRNKEMKVAMRRLFSHLVHYRNIS", "length": 312 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AP00-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258730", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "SRHDLHCSLWQDNSMSVKRFAFARFSEVTEQCFLLFTLILLMFLASLTGNALIATAIWTNPVLHTPMYFFLANLSLLEIGYTCSVIPKMLQSLVSEARGISREGCATQMFFFAFFGISECCLLAAMAFDRYMAICSPLHYATRMSRGVCDHLAMVSWGVGCMAALGQTNYIFSLDFCGPCEIDHFFCDLPPILALACGDTSHNEAAVFVAATLCISSPFLLIIASYGRILAAVLSMPSPEGRRKALSTCSSHLLVVTLFYGSASVTYLRPKASHSPGIDKLLALSYTVVTSMLNPIIYSLRNKDVKAALRRTLGKKKVLAHR", "length": 322 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287ARD5-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258934", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDGKNQTALSEFIILGFSNLNQLQFLLFTIFFLTYICTLGGNTFIILVTVVDPRLHTPMYHFLGNLAFLDICYTTTNVPQMMAHLLSEKKSISYGGCMAQLFAFIFFVGSECLLLAAMAYDRYIAICKPLRYSVIMNKVLYSQLAASCWSGGFLNSAVHTVLTFRLPFCGNNQINYFFCDIPPLLVLSCGDTSVNELALLSIGVVIGWTPFLCIVLSYLYIISTILRIRSSKGRQKAFSTCASHLTIVLFYYGSAIFTYVRPISSYSLEKDRLISVLYSVVTPMLNPIIYTLRNKDIKEAMKAVGRKWQLPLLSFDV", "length": 317 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AT12-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLSFNRTGVSHTVFYLLGIPGLEDQHLWISIPFFISYVTALLGNSLLIFLILTRRSLHEPMFLFLCMLAGADLVLSTCTVPQALAIFWFRAGEISLDRCITQFFIIHCIFMSESGILLVMAFDRYVAICYPLRYTTILTHTLIGKIGVTIFLRSYCTVFPIIFLLKRLTFCRNNVLPHTGCEHIGLAKYACNDIRVNIWYGLFVIVSTLFLDILLIFVSYMLILRAVFHMPSQDARHKALSTCGSHVCIIILFYGPGILTTLAQRFGRHIPAHIHILLANVCVLAPPMLNPIIYGIKTKQIQEQVAHLFLKQK", "length": 313 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AUC4-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MERINKSHPEEFILLGFADRPWLELPLFIILPMYFFLTNLSFLDMCYTTSIVPQMLFHLGGSEKTISYLGCAVQLYFFHTMGGTECLLLALMSFDHYVAICKPLHYTLIMNRCTCILLVATVWLSGMTYAVSEATVTLHLPLCGHNTLDHLICEIPVLIKAPCGEKGTNELTLSVVCIFMLAVPLCFILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVFFFYGPDISMYLQPPSSISRDLPKFMALFHGVVTPTLNPFIYTLRNKDVKGAWGNLVRSVFTSK", "length": 286 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AXC2-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEQNNGTEVNEFILLGFAGQHKSWLVLFIVFLGIYVVTLVGNIGMILLIKIEMLQNFVGTEQSISFIGCMVQLLIYGAFVTSDCYILAAMAVDRYVAICNPLRYPTVMSQRVCIQLLIGSYLIGFLNASVHVSFILPLNFCKSNKINHFFCDAPPILALSCSSIYFNVMLLAAFVGFNLTCTVLVVIFSYIFILAAILKISSAAGRKKAFSTCASHLTAVTLFYGTLSYMYLHHRTLESQEQEKLASVFYGIVIPMFNPLIYSLRNQDVREALKGVGKQCF", "length": 281 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287AY25-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100155405", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAHTNESVVLEFVLLGLTNSWELQLFLFAIFSIVYVTSVLGNTMIIVIIASDSRLNSPMYFLLSNLSFIDICQSNFATPKMLVDFLVEHKTISFEGCMAQIFLLHSFVGSEMMLLVAMAYDRFIAICKPLHYSTIMSRRLCIIFVFISWAVGILHSVSHLAFTVDLPFCGPNEVDRFFCNLPLVIELACMDTYKVEILTLTNSGLISLGCFLALIISYTVILITVHRWSSSGSSKALSTLTAHITVVILFFGPCIYFYIWPFSRLSVDKFLSVFYTVCTPLLNPIIYSLRNEDVQSAMHKWRNHHVNSWKY", "length": 311 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287B1Z6-1", "protein_name": "Short stature homeobox", "gene_name": "SHOX", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEELTAFVSKSFDQKSKESSGGGGGGGGKKDSITYREVLESGLARSRELGGSDSNLQDITEGSGHCPVHLFKDHVDNDKDKLKEFGTGRAAEGIYDCKDKREDVKSEDEDGQTKLKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQMHKGVILGTASHLDACRVAPYVNMGALRMPFQQVQAQLQLEGVAHAHPHLHPHLAAHAPYLMFPPPPFGLPIASLAESASAAAVVAAAAKSNSKNSSIADLRLKARKHAEALGL", "length": 292 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287B9C9-1", "protein_name": "HSF-type DNA-binding domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAHAPSEIQGVSPKDESTGSESSITSPWCDNSITGDLDLRSQIEEKAFQALSEGSLMKEPCHTLCASEPDGDNDFPPLPFPRKLWEIVESDRFKSIWWDENGTSIVINEERFKKEVLERKAPFRIFETESMKSLVRQLNLYGFTKLRRNFQRPASLANILAEDNEVSAWNKLQFYHNPNFKRGCPHLLVRMKRRVRVKNASPVSASVLQGCSKKRSRTGGDVDNHNSDVAAETRGEDAFSASTNLNVPLIRWRSMSQRISNTTTPTRSGLSSPSSPSFRPPGQIAMAQHAIFSQLTTFHMHSQSSYSPASGHIVNFITTTTSISQYRCISYFPSGYFGLRVEPSPLPTRYQNISPTECPVSNPQPAAHPWFPMPMATDTSAASLSRPNPQSSSVSEHHPNYH", "length": 402 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BB76-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100157512", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAHTNESVVLEFVLLGLTNSWELQLFLFAIFSIVYVTSVLGNTMIIVIIASDSRLNSPMYFLLGNLSFIDICQSNFATPKMLVDFLVEHKTISFEGCMAQIFLLHSFVGSEMMLLVAMAYDRFIAICKPLHYSTIMSHRLCIIFVFISWAVGILHSVSHLAFTVDLPFCGPNEVDSFFCDLPLVIELACMDTYKIEILTLTNSGLISLGCFLALIISYTVILITVHRWSSSGSSKALSTLTAHITVVILFFGPCIYFYIWPFSRHSVDKFLSVFYTVCTPLLNPIIYSLRNEDVQSAMHKWRNRHVNSWKY", "length": 311 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BC21-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100152520", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDGKNQTALSEFIILGFSNLNQLQFLLFTIFFLTYICTLGGNTFIILVTVVDPRLHTPMYHFLGNLAFLDICYTTTNVPQMMAHLLSEKKSISYGGCMAQLFAFIFFVGSECLLLAAMAYDRYVAICKPLRYSVIMNKVLYSQLAASCWSGGFLNSAVHTVLAFRLPFCGNNQINYFFCDIPPLLVLSCGDTSVNELALLSIGVVIGWTPFLCIVLSYLYIISTILRIRSSKGRQKAFSTCASHLTIVLLYYGSAIFTYVRPISSYSLEKDRLISVLYSVVTPMLNPIIYTLRNKDIKEAMKAVGRKWQLPLLSFDV", "length": 317 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BF45-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100513333", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRNRTITTFILLGLTDDPELQVLIFIFLFLAYMLSLTGNLTIITLTFVDSHLKTPMYFFLKNFSFLEVSFISSCIPRYLYSIATGDKIITYNACFIQVCFTDLCGITEFFLLAAMSYDRYVAICKPLHYVTIMSSRVCGILISSCWMAGLCVLIPPLSLGLNLKFCDSNRLDHFGCDAFPLVKISCSDTWPMEQTVIICAVLTLNMTLTCVVLSYAYIIKTIFRFPSDQQRKKAFSTCSSHMIVVSITYGTCIFIYMNPTAKGEVTIKKVVSLLIFSVSPTLNPFIYTLRNNQVKRAFKDSIKRIALLSTR", "length": 311 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BGE2-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MENNQSWIAEFILVGFQLSEEMELFFFIIFFLLYIFNLLANGMILGLICLDPRLHSPMYYFLTHLAVTDISYASSNLPNMLENLVKHKKTIPFVSCTLQMLFYLAFASVECLILVVMSYDRYVAICHPLQYTVIMNWKLCTVLAIISWACGFFLALVQVSLFLRLPFCGPQKVNHFFCEIRSVLKVTCGETWINKIFLFADGVFILVTPISLMLVSYVRILWAILKIQSKEGRKKAFSTCSSHLCVVGFYFGIAMMVYLVPDDSHQQEEQQKILFLFYTFFNPLLNPLVYSLRNAQVKAAFHRIFQKNRTM", "length": 311 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BIM6-1", "protein_name": "Histone H2A", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPGKRSRRKSPGRQGRTCARTTRAGLSASVSHMERLLREGPYAQCLSSSARVFLAATIEYLTARVLELAGDEAQIVGRRCITPELVAMAVHNNALLSAFFGTLAISQVAPTQE", "length": 113 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BK27-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVTEFIFLGLSNSQELQTFLFVFFLVFYVGIVFGNLLIVLTVMIADFFRKCKVISFKGCLAQIFLLHFFGGSELVILIAMAFDRYVAICKPLRYTTIMSSNVCVGIVAAAWGTGFLHSVSQLAFAVNLTFCGPNEVDSFYCDLPRVIKLSCTDTYRLDIMVIANSGVLTVCSFVLLIISYTVILVTIQHLPSQKSSKALSTLTAHITVVLLFFGPCIFIYAWPFPIKSLDKFLAVFYSVVTPLLNPIIYTLRNKDMKTAMKRLRKWNMNSRIKP", "length": 274 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BKA6-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110259008", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTFNCSLWQDNSMSVKRFAFARFSEVTEQCFLLFTLILLMFLASLMGNALIATAIWTNPVLHTPMYFFLANLSLLEIGYTCSVIPKMLQSLVSEARGISREGCATQMFFFAFFGISECCLLAAMAFDRYMAICSPLHYATRMSRGVCVHLAMVSWGVGCMVGLGQTNYIFSLDFCGPCEIDHFFCDLPPILALACGDTSHNEAAVFVAATLCISSPFLLIIASYGRILAAVLSIPSPEGRRKALSTCSSHLLVVTLFYGSASVTYLRPKASHSPGIDKLLALSYTMVTSMLNPIIYSLRNKEVKVALRRTVGKKKVLAHR", "length": 320 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BKW4-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258932", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGENQTVLFEFIILGFSNLKELQFLLFTIFLVTYICTLGGNSFIILVTMTNLHLHTPMYFFLENLAFLDICYTTTNVPQMMAHLLSEKKSISYLGCMAQLFAFIFFVGSESLLLAAMAYDRYIAICKPLRYSVIMNKVLYSQLAASCWSGGFLNSAVHTVLAFRLPFCGNNQINYFFCDIPPLLVLSCGDTSVNELALLSIGVVIGWTPFLCIVLSYLYIISTILRIRSSKGRQKAFSTCASHLTIVLLYYGSTIFTYGRPISTYSLEKDRLISVLYSIVTPMLNPIIYSLRNKDIQEAMQVMGRKWKASSSLSFDV", "length": 318 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BLZ6-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "LOC110258167", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGGKNSTTITKFILLGFSEFPKLTAVLFSVFLRISLMTVSWNMGLIMLIRMDSHLHTPMYFFLSNLSLLDICYVSTIAPRMLSDFFKKYKFISFMGCTMQYFFSSLALTECCLLAAMAYDHYAAICNPLLYTAIMSPTLCVQMVAGSCVTGFFGSFIQLCALFQLHFCGQNVTNHFFCDLPQLLILSCSDTFFFQVMTSVLTVIFGLTSVLVIIISYGYIIATILKITSSEGRSKAFNTRASHLTAVTLFFGSGIFIYMYPNSGDSLSQNKLVSVLYTVIISMLDPLIYSLRNKEIQDSLSRWRKTIFSWCY", "length": 313 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BNL4-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "TVLNARNVSTPKVFILLGFSDHPWLEMPLFIIVLAAYIRTLVGNISIIVVSRVDPNLDSPMYFFLSNLSFLDLCFTTTTIPQLLLNLWGPDKSISYGGCVTQFYMFHFWGATECIFLAVMSMDLQAICKPLRYPVIMHQQLCIFLVVMAWLSGLVNSLLQSSLTIQLPLCGNNKVDDFLCEVPVMIKMSCTDTTFNVAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIQSSEGKKKAFNTCSSHTIAVSLFYGPVISMYVQPSAANSQDKNKLMSLFYSLVTPMLNPFIYTLRNKDMKGAMMRLLVSLYHQRRG", "length": 315 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A287BSD4-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100525471", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MENENSTVVAEFIFVGLTQSRNIQLLVFVLILIFYLIILPGNFLIILTIRSDPGLTAPLYFFLGNLAFLDASYSFIVAPRMLVDFLSEKKVISYRGCITQLFFLHFLGGGEMLLLVVMALDRYIAICRPLHYSTVMNLRACYALLVALWLGGFVHSIIQVALILHLPFCGPNRLDNFFCDVPQVIKLACTDTFVVELLMVFNSGLMTLLCFLGLLASYAVILCRVRGSSSEGKTKAMSTCTTHIIVIFLMFGPAIFIYTRPFRAFPADKVVSLFHTVIFPLLNPVIYTLRNQEVKTSLKRLLNQQLA", "length": 307 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A2R8VHJ9-1", "protein_name": "Predicted gene, 36245", "gene_name": "Gm36245", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTKNEEQNEDQSEGVVIPHIQDHHCLAILAFCFFFPLGYLAYRSSCKTRTYIEQKEYEKAKATSRCTFAFVLSSIAGGSIIFFCLFSRLFFM", "length": 93 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A3L7ICH5-1", "protein_name": "Cytochrome c oxidase subunit 7A2-like, mitochondrial", "gene_name": "LOC100756118", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MYYKFSGFTHKLAGAWALESYSPQGLKPVASTEAPPIVFATPTKLTSSVTAYVYAGKNKVPELQKFFQNFFHLKRGLPDQMLYRTPMALTVGGTIYCLSALYMASQTPNK", "length": 110 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A3Q1LL21-1", "protein_name": "BTB domain-containing protein", "gene_name": "LOC112445444", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MGPLNSRNLQCRESGTGELQQPEAQAGPSYVSGSRKRKQSTGPSLGPESEMSHNQEEDLQQVVCTRQGKKVKIKSEYAYQTLFLNGETSDIKIRALGKVWCLHKRFLCQSDYFATMFRDSGKECHKDIIDLEINDQNINVESLQFVLGSLYRNEYVLIKPLQVPRVLATACLLQVEDLIQQCDKTMKETINVKTVCSFYVAAETYGLHSVKTGCFEWLLHNLMTHPSVELYKKLSTDLMNLVISSSNLFVMQKEIDIYTTLKQWMFLRLNPGWKGTMKQLLVNANNWFSRHKEHDGSISFLETKQGIVFQPVFKNLRFQHIICDLASTKVIEQDALIPSEWLSCVYKRQWYTLLRAQQYREIGPRDITETELEEYSMRCGKRIVRDGTYAWKWSGYNFGVHLYVVFTSHFIIFKRHAFSQPYDGSICLQPQRNIAFRLTLVYFGSSGKLSFRKTTGYKILTFEKDEEQMVMKLDSVALSFPLYIFCNFLFISLENPGN", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1LLV6-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MNLFIYVLLLSIWTSSCLDRNESNGSATAVTTHAEFKQTKLQELRRRLLIIIIGTLITGYMVTCTCFLHYSCDSEEAHKATKDKKEDITIKASRSSKISFTDSKSPTAGLGDPERQSVVSRIDKSSGPSSPRKVPSSAEKLVRPSSQKKPSKPSAPKKVLGSPPQEKLHRTRSPKKAHRQAHAHKLVSQVSPSYPEKAIKPTWPPSLQCRVKPTKTPLPYPKNQSFPEHSSADKLTKRQRYLKLKCPASAGRAEILSRPQPVKFCRCYKEKCLVCRAVSEPFITHVSEANKKHVPVPLFSRELKHFYKSYKKKQPKYNTLYGNMSDSDITTYNSDGESDREVIIMCNIKCKEDIYKNSPNN", "length": 361 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1LUU6-1", "protein_name": "Guanylyl cyclase domain containing 1", "gene_name": "GUCD1", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MTGPRCRRKQRPSGRPGPRGTRAPQHPTPDAGWTARRAAGAAGAEARGRDLPPQRKPAKPTAPGKGRPERGECPRRADRGGGDPEERAGGRPAWGPGAGRGGAWGRSRLPPLLPPGRWCWRPGKPARAGRALSSPVDARAAAGAGPGPWEPRAARVMRTEVDAEAAGPPLEPDEPTQSLSIQDQETAFLLEDSCQLKPGQPLPGRPWPSGDFVQLPVPIIQQLYHWDCGLACSRMVLRYLGQLDDAEFEQALQELRLTRSIWTIDLAYLMRRFGVRHRFCTQTLGVDKGYRSQSFYRKHFDTEETRVNQLFAQAKTCKVLVEKCRVSVQDIQAHLAQGHVAIVLVNSGVLRCDLCSSPPKYCCFTPSGPRCFCRSPDYQGHFIVLRGYSRAAGCVFYNNPAYADRMCSASISNFEEARTSYGTDEDILFVYADS", "length": 434 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1MFB0-1", "protein_name": "Uncharacterized protein", "gene_name": "LOC112441459", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MNLFIYVLLLSIWTSSCLDRNESNGSATAVTTRAEFKQTKLQELWRRLLIIVIGTLITGYMVTCTCLLHYSCDSEEAHKAAKDKKEDITIKASRSSKISFTDSKSPTAGLGDPERQSVVSRIDKSSGPSSPRKVPSSAEKLVRPSSQKKPSKPSAPKKVLGSPPQEKLHRTRSPKKAHRQAHAHKLVSQVSPSYPEKAIKSTWPPSLQCRVKPTKTPLPYPKNQSFPEQSSVDKLTKRQRYLKLKCPASAGRAEILSRPHPVKFCRCYKEKCLVCRAVSEPFITHVSDANKKHVPVTLFSRELKHFYKSYKKKQPIYNTLYGNMSDSDITTYNSDGESDREVIIMCNIKCKEDMFKNSQNN", "length": 361 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1MI36-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MGSSSGSKAEFIVGGKYKLVRKIRSGSFGDMYLAINITNGEEVAVKLESQKARHPQLLYESKLCKILQGEVGIPHIRWYGQQKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMMGRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASISAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRHLFHILFRTLNHQYDYTSDWTMLKQKAAQQAASSSGQGQQAQTPTGF", "length": 325 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1MQ28-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "KEQVLQPTTVVSLEGAVAEISCNHSVSDVYDFFWYLHFPGFAPRLLIKGLGPSQQGRYNMTYERFSSSLLILQVQTADAGVYYCALRYTEAGHP", "length": 94 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1MT47-1", "protein_name": "Uncharacterized protein", "gene_name": "LOC112444909", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MLGCEGGKRPLKPPKKQAKETDEEGKAFKHKQKEEQKTLEGLKGQIMGKVPLATGGIKESGKQ", "length": 63 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q1MUP8-1", "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "LOC100336539", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MSRLTERALPTGTSNGAPSSRRAPVLTGTTVSNNDLASLFECPVCFEYVLPPITQCKSGHLVCGNCRPKLTRCPTCRVPLTSIRNLAMEKVANLVLFPCKYTSSGCGKTMPPTEKADHEEHCEFRPCRCPCPGTSCGWQGSMDAVVPHLMQHYNESIITLRGEVVVFLAVNINLAGTLEWVMLQSCFGFHFLLVLEKLEIYDGHQKFFAVVQLIGTREQAENFTYQLELNGNRRRLSWEATPLSIHEGIATALINSDCLIFDSEVAELFAENGNLSIDVTISMC", "length": 284 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q2TUK0-1", "protein_name": "Uncharacterized protein", "gene_name": "LOC121109925", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEQQGHGERGNWQTKVWKTVALVLVTVAVASFGVYCVGGLVEGIKTTAGVTARLVRRDGEIVSLDEELAKVQRQLHVLQWRARDITERALHEALRRTELPGFTGEAVQKIIHQVLEKLEESPFQMTNYASKTSGAAIVRSKTSPSWIGSGRVFWQSLPLVAYMRPPEVILEPDNHPGNCWPFPGSQGHVFIKLPVAVFPTAVTINHGVPAAAYHADSISSAPKDFAVYGLQEEDDEKGTLLGEFIFMPGQAPGQTFQLKNEHSAFIKYVRLQVLSNWGHPEYTCVYQFRLHGDPAPDGDARGKLSA", "length": 306 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A3Q2UEY0-1", "protein_name": "Mab-21-like HhH/H2TH-like domain-containing protein", "gene_name": "LOC124418381", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALVLVLALLVRALIVSGSDHAVMLERVQQHEKEQRNGEQSWVDMPALLFTLLHYWKIWLCTGLFVFLFWNMWRSLKRKQHEEGGQQEQQEREEQVEEVEPEEQQEQVEQEEQLERVEELERVDQVEHVEQEEREDQGEQVQQEEQVEEVEREDEEDEYFYHSALTRYIARRAWEKMQGRATKCVLVEELMRDLLQTFTFVCPNSFYPVLQPAIGVGSAFEGWSPCEEDIVYHLLVPIKAPHGHVFHPELGEEGDMLARNSRIRVELVCMCTREQQLGDVLCFLHHSQEELSQNQQPSLLQTLCTGSYLDVQKTAAWFNKQVPRIWRLTHRAHRYGLKVLPSSRSCKLQVTDTSSGEKVHVELLFGVQQGNLDIFLSSQNAEAVFTPSTTWPQSCAVAERKYFEYVARTAGPNSCHLVCLRLFAHILVGMGFSSYTIKTLLLHLLAIIPLEDWRRRHFLSRLENLLQYLQYCLNDKLLNHFLLGNATMPDEVVLPQAFQTASPLNLFQHLEQDPDAHSRALRDFKELKDRLFRLLLFGR", "length": 539 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A494C0N9-1", "protein_name": "Protein FAM246B", "gene_name": "FAM246B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATPGRPWAQARSAYRASEVLRRVTGRRRDPGPQSNGPGREDARAPGRLARLLRQLRAEAASRSEVPRLLKLVERAGAGAAGAGERTGAHSRGSVCSVCGEPRGRATYPAGVLEVSERRLQEGLAAVREELGAEIEALRAELRAELDALRALLPPPPPSPPARREPRAVPRAAPRGPTLLRTLGTVSALVAASRPADDAPDGPAECGAHRAPARKNHKKMPVPPGAPQGGGD", "length": 232 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A494C0Z2-1", "protein_name": "Speedy protein E13", "gene_name": "SPDYE13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQILGKIMMSHQPQPQEERSPQRSTSGYPLQEVVDDEVLGPSAPGVDPSPPRRSLGWKRKRECLDESDDEPEKELAPEPEETWVAETLCGLKMKAKRRRVSLVLPEYYEAFNRLLEDPVIKRLLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEAPKQNIFYFLYEETRSHIPLLSELWFQLCRYMNPRARKNCSQIALFRKYRFHFFCSMRCRAWVSLEELEEIQAYDPEHWVWARDRAHLS", "length": 265 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A0A4X1TRA8-1", "protein_name": "Small ribosomal subunit protein eS19", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPGVTVKDVNQQEVVRALAAFLRKSGKLKVPEWVDTVKLVKHKELAPYDENWFYTRAASTPRHLYLWGIAGVGSMTKTYRGHQRDRVMPSHFSRGSKSVAHRLLQAREGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAAKKKH", "length": 145 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A4X1TY10-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100627324", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MENYNQTSIYFILLGLFPSSRIGMFLFIIIVLIFLIALFGNFSMILLIFLDNNLHTPMYFLLSQLSLMDLTYISTIVPKMAYNFLFNDKSISFIGCGIQSFFFLTLAGAEGLLLAAMAYDRFVAICFPLHYHIRVSKRICVLMIIGSWIMGSINSFAHTAYALNIPYCQSRAINHFFCDVPAMLTLACIDTWVYESTVFVSTTIFLLVPFTCIAFSYGRILLVVHHMNSTEGKKKAYSTCSTHLTVITLYSAPFAYTYLRPKFLRTPTEDKVLAMLYTIFTPMLNPIIYSLRNKEVMGALRRVIQRICSVKM", "length": 312 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A4X1U699-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100524234", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRRENQSSVSMSKFVLVGLHIWPEQQGMVFALFLGMYLTTVLGNLLIILLIRLDPRLHTPMYFFLSHLAFSDVSFSSVTVPKMLMNMQTQDQSIPYAGCVTQTYFFIFFSCIDNLLLAVMAYDRYVAICHPLRYAIIMKEELCLCLLAGSWLLSCAYALTHTLLLAQLSFCADNIIPHFFCDLASLIKLSCSDTSLNELVIFSLGPAVFIFPLSGILVSYGCIVVSILSVHSPKGIFKALSTCGSHLSVVSLFYGTSMAVYLSSSSGQSHDKDTIASIMYTVVTPLLNPFIYSLRNRDMTLALQILFRNSNLLAK", "length": 315 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A4X1VK25-1", "protein_name": "Elongin-C", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "RSYGGCEGPDASYGKLIASDKFIVKREHVLTSGAIKAMFSSPGQFAEKETDVVNFRETPSGIPSAALWKVCMYLPHKVCYTSNTSEIPEFPINSEFPIAPDIALEPLMAANLLDC", "length": 115 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A571BD55-1", "protein_name": "BTB domain containing 35, family member 26", "gene_name": "Btbd35f26", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSVYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A571BF50-1", "protein_name": "WD repeat domain 88", "gene_name": "Wdr88", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTKDNEEILNSPDQVRKGSPDVKKKKKIKKKRVKPKGDLDSKKLDFVEDSWWKGSLKNKNLDFAEYNWVLVDNRRVSVDSRKSSADSKRGSADSKRGSADSKRGSADSKRGSADSKRGSVDSKRGSVDSKRGSVDSKRGSVDSKRGSVDSKNRFSPKKMDFSEDREISQPTFLRAQQSKVPWALMRALGLFKLSLPDIRRYYNLTSHDPLALDKDRQPREKSHMATVKKFWGNQQPLSKIPYKILIGHDHIVSSCHFCMNDTRFLSSSYDCSVKLWDAEDGTVIWDFEPRPKAPVLECSITADNRRIVASSYDKTVRAWDVETGQLLWKVRHDTFVVCCKFSPNGKFVLSALDVDRGIYLMDPENITTVIHMKDHHQRSITSCCFDPDSQKVASVSMDRCIKIWDITSRTTLFTIPKAHYNAISDCCFTSTGHFLCTSSWDKNIKIWNVHTGEFRNRGACVTLMKGHEGCVSSCCIARDSSFLISGGFDKTVAIWDVGGGYRKLALKGHEDWVTDVAISNNKKWILSASKDSSMRLWNIEEIDKIPLVSENKKAMGLKVRQVGIR", "length": 565 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A571BG45-1", "protein_name": "BTB domain containing 35, family member 25", "gene_name": "Btbd35f25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGLQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A571BG86-1", "protein_name": "BTB domain containing 35, family member 8", "gene_name": "Btbd35f8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLSCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESRHGVINLIIKNEDIDTRSLHFVFGALYRDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A5G2QG78-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100523228", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTRGENTTNITDFVLLGFSDFPQIRAALFVVFLVIYILTLTWNLCLIVLIRMDSHLHTPMYFFLRNLSFIDICYVSSTAPKMLYDFFQAKPTITVVGCAIQYFVCSTMGLSECGLMTVMAYDRYAAICNPLLYSSTMSPSLCGRMVLGSYMAGLSASLSQVCAMLQLHFCGPNVIHHFFCDMPQLLVLSCSDTFFLQLLTLVLTVIFGILNALVIMMSYVYIVISVMKITSTKGWSKAFNTCASHLTAVTLFYTSIIFVYLSSSSGGSSGLDRFAAVFYTVVIPMLNPLIYSLRNKDIKDAWKRLKKRKECC", "length": 312 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A5G2QIN7-1", "protein_name": "ADAM metallopeptidase domain 7", "gene_name": "ADAM7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSNSHYLSALFSREFLASNYSETYYSTKGEEVTTHPQIMDHCFYQGSIIHEFDSAASISTCSGLRGFFRVNDQRYLIEPVKYSDEGEHLVFRYNPKVQHAANYSCTELNFTRTAVLKDNTKSMEDSKMESIEKEKHIELFIVADNNVYHRNPNSKVRNRVWGMVNFVNMIYKTLDIHVTLVGLETWTNGDKIEIDSNIETTLKRFSAWQEIILKKKKNFDHVVLLSGKWLYTSAQGTSYPGGMCLPYYSSSVVKDLLPDLNTIASRMAHQLGHSLGMKHDDYPCTCTLGKCVMDSGGSIPALKFSKCSRTQYQQYLKDFKPTCMFDIPFSDKLSDYPYCGNKKLDDGEECDCGPVQECTNPCCDARKCMLKPEFTCAEGECCESCQVKKAGSLCRPAKDECDFPETCTGHSPACPKDQFQVNGFPCKDAKGYCFMGNCPTRDDQCSELFDNEAKDSSDICYKMNKNGNKFGYCKNEEQTLIPCEEKDVKCGKIFCTGGKHASILGEEKVYHLKKPLTQNVTECKTFFLYHKSKDFGLVAPGTKCGEGKVCSNSECVTIEKAYNSTDCPSPCNENAVEDGDLGCQCEGVQASVDWEETLNVTNISILVVVLILVIIGVLSAVLLIRYQKCIKLKQVQRPPSEALGVENKGYTGDEQQTRTEPILPDIHPLHRRTAESLARLPTSFSSPHYITLKPASKEPRGTADPNPSAKVSLKLDIQNGCASLS", "length": 725 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A5G2QM02-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100623139", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTGGENTTNITAFVLLGFSDFPHIRAALFVVFLVIYILTLTWNLCLIVLIRMDSHLHIPMYFFLSNLSFIDICYVSSTAPKMLYDFFQAKPTITVVGCAIQYVVFSTMGLSECGLMTVMAYDRYAAICNPLLYSSIMSPSLCGRMVLGSYMAGLSATLSQVCAVLQLHFCGPNVIHHFFCDMPLMLGLSCSDTFFVRVLTAVFTVIFGIINALVIMMSYVYIVISIMKITSAKGWSKAFNTCASHLTAVTLFYTSGIFVNLNSSSGGSSGLDRFAAVFYTLVIPMLNPLIYSLRNKDIKDALKRLKKRKECC", "length": 312 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A5G2QUE5-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100524011", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRRENQSNVSKFLLLGLPIQQEQQGMFFALFLGVYLTTVLGNLLIILLIRLDPRLHTPMYFFLSHLALTDISFASVTVPKMLMNMQAQDHSISYAGCVTQTYFFMFFACIDNLLLTVMAYDRYVAICHPLRYTIIMREELCICLLAGCWLLSCAYALTHTLLLAQLSFCVDNIIPNFFCDLAALLQLSCSDTSLNELVIYTSGAAVFIFPPSGILVSYGRIGISILRVPSTKGICKALSTCGSHLSVVSLFYGTIMALYFSPSFGQSHYKGIIASVMYTVVTPMLNPFIYSLRNRDMTLALEILIRNKNLFTT", "length": 313 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A5G2QWK6-1", "protein_name": "Calmodulin 3", "gene_name": "CALM3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "VSAEREEEGVALKFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEVTASPVLGPAREGPRASAPSWGGKQPLAIACNQPRRSSGFSWDLPSFENLLSSTLWSPASGDGRGVEHSGRPS", "length": 214 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A5G2R7Y6-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100524140", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGQRNQTSSLADFILEGLFDDSPAHAFLFSLTMVVFLVAVSGNTLTILLICADPRLHTPMYVLLSQLSLMDLMHVSTTIPKMAINHLSGTKSISFVGCATQYFLFLSLGGAECLLLTFMSYDRYVAICHPLRYAVLMNRKVGQMMAVMSWLGASVNSLIHTVILMHFPFCGHRNIHHFYCEFPAVVQLVCGDITVYEIAVYIGDIVLLLLPIVLISASYVFILHSVIHMHSAGGKRNAFATCSSHLTVVSLWFGACIFSYMRPRSQRTPLQDKVGSVFYTIITPTLNPLIYTLRNKDIAKALKRVLGREMITQNPKVRLP", "length": 320 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A5G2RGH3-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100524855", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGRRNQTSSLADFILEGLFDDSPAHAFLFSLTMVVFLIAVSGNTLTILLICADPRLHTPMYVLLSQLSLMDLMHVSTTIPKMAINYLSGTKSISFVGCATQYFLFLSLGCAECILLTFMSYDRYVAICHPLRYTVLMNRKVGQMMAVTSWLGASVNSLIHTVILMHFPFCGHRNIHHFYCEFPAVVQLVCGDITVYETAVYISDIVLLLLPIILISASYIFILHSVIRMHSAGSKRNAFATCSSHLTVVSLWFGACIFSYMRPRSQRTPLQDKVGSVFYTIITPTLNPLIYTLRNKDIAKALRRVLGREMITQNPKVRLP", "length": 320 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A668KLA6-1", "protein_name": "Predicted gene, 52955", "gene_name": "Gm52955", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSSSEHCNVSDWLRLEATVKASVYVVAFSITTSLTIVIIAIVSQSLQLRKEVRLVLLCHHLLCISSYCGLGVVFQGMGALLANSPLLLCWLVFGAQLSVGEGILLTLTLMALNTYLAICYPLNSPSFVDSAKYRILAGTWTTVILKNVGLFLIEGTSPTPASVFQSAPLCPVILNGMPARVIGMFSLAFLLSVILVSYCLIYREGKRAGHFNKSNIKARRTVLVHLLQISLHVIPTLIIIGLGKQCGVFFFALNLALFGIFAFAQCFNPLVYGLHNRDLQSKLYPSLCCQKKLLP", "length": 296 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A668KLA7-1", "protein_name": "Predicted gene 7582", "gene_name": "Gm7582", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSSSEHCNVSDWLRLEATVKASVYVVAFSITTSLTIVIIAIVSQSLQLRKEVRLVLLCHHLLCISSYCGLGVVFQGMWALLANSPLLLCWLVFGAQLSVGEGILLTLTFMALNTYLAICYPLNSPSFVDSAKYRILAGTWTTVILKNVGLFLIEGTSPTPASVFQSAPLCPVILNGMPARVIGMFSLAFLLSVILVSYCLIYREGKRAGHFNKSNIKARRTVLVHLLQISLHVIPTLIIIGLGKRCGVFFFALNLALFGIFAFAQCFNPLFYGLHNRDVQSKLYPFLCCRKKLLP", "length": 296 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A668KM50-1", "protein_name": "RIKEN cDNA A930007A09 gene", "gene_name": "A930007A09Rik", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSLSELPQKNTDLAEMQSGPLGRCSHFFWLGVAFDAVGVAVLFTGVFANLLFYDMLLYLGSIIIFVSLLWWISWYTGNIEALPEDPLRGTSPRESGVHRSGSRRFSLTLRSVSDTFQRIRRRRRRRLHPRVVQRISSISSTDPGQLERNCDARTSGGRALFRSAKPEAVLNQFSRVQTSKSLPLGIVHTGLSICTSRSQPVFSVTSQTYPLASDSNSQMAMSSDSHVYLDSHSQEHSKISVASQIYPLEREESQSHLLVIPDSLSMVPVTSQSQILPSVSSESCVPLGPHSQGRSKISVATQIYPLEREESQSHFLVIPDSLSMVPVTSQSQILPSVSSESCVPLGPHSQGRSKISVASKIYPLEREESQSHLLVIPDSLSMVPVTSQSQILPSVSSESCVPLGPHSQGRSKISVATQIYPLEREESQSHFLVIPDSLSMVPVTSQSQILPSVSSESCVPLGPHSQGRSKISVASKIYPLEREESQSHLLVIPDSLSMVPVTSQSQILPSVSSESCVPLGPHSQGRSKISVASQIYPLEQEESQSHFLVPMPSDSFPVVPMTSQSQIQGSLAQQSHLQNLPLASQTPETDKASKSHTLAKGVPGVPPGSAQTQHPQASLAQTSQISSPVRKVPKN", "length": 636 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A8C2LDI6-1", "protein_name": "Large ribosomal subunit protein eL33", "gene_name": "LOC100774916", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGRLWCKAIFAGYKRGLCKQRGHTALLKIEGVYARAETEFYLGKRYAYVYKEKNNTVTLRCKPNKARVIWGKVTKAHGNSGMVHAKFRSNLPAKVIGHRIRVVLYPSRI", "length": 110 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8C2LMV8-1", "protein_name": "Large ribosomal subunit protein eL21", "gene_name": "LOC100755948", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTNTEGKRRGTRYMFSRPFRKSEVVPLAMYMRIYKKGDIVDIKGMDTVQKGMPHKCYHGKTGRVYNVTKHAVGIIVNKQVKGKILAKRINVQMKHIKHSKSRDSFLKQVKENDQKKKEAKEKGTWVQLKRQPVPPREAHFVRTNGKEPQLLEPISYEFMA", "length": 160 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8C2LSR6-1", "protein_name": "Large ribosomal subunit protein uL5", "gene_name": "LOC100751955", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSQDEGEKENPMWELHICKLCLSICVEESRDRLTRAAKVLEQLKGETPVFSKARYTMRSFGIRSNEKIAVQCTVHGTKTEEILEKGLKVQEYELWRNNFTDTGNFGFEIQEHIDLAIKYDPSIRIHGLDFYVVLGRPGFTIADKHRTGCIGAKHRISKEEAMRWFQHKYDGIILPGK", "length": 177 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8C2LUM6-1", "protein_name": "Tubulin alpha-1C chain-like", "gene_name": "LOC100757824", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MCECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETDTGKHIPRVVFVDLEPTAIDEVRTGTYRQLFHPEQLITGNEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSRFTSLLMEWLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYPTPLPE", "length": 288 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8C2LZU4-1", "protein_name": "Glia maturation factor", "gene_name": "Gmfg", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSDSLAVCEVDPELKEKLRKFRFRKETDNAAIIMKVDKARQMVVLEEEIQNVSPEELRLELPERQPRFVIYSYKYLHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVFEIRATDDLTEAWLQEKLAFFG", "length": 142 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8C2M625-1", "protein_name": "U3 small nucleolar RNA-associated protein 15 homolog", "gene_name": "LOC100755487", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGYKPVAIQTYPVLGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIQTFREHSDYVRCGCASKLNPDLFVTGSYDHTVKMFDARTNKNVLCVEHGQPVESVLLFPSGGLLVSSGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALSHEDETIVVGMTNGILSVKHRKSEAKKESLSRRRRPAYRTFVKGKIYMKQRDDIMINRPAKKHLEWYDKDLKSFRISKALDRVLEPNCVIKTPEVTVSIIKELNRRGVLANALAGRDEKEITRVLNFLIRNLSQPRFAPVLINAAEIVIDIYLPVIGQSPVVDKKFIVLQGLVEKEIDYQRELLETLGMMDMLFATMSRNDSVSLSENVPAELPEKTESPCQPGDTDKNS", "length": 527 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8C2MXE3-1", "protein_name": "Glycerol-3-phosphate acyltransferase 1, mitochondrial", "gene_name": "Gpam", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDESSVTLGTIDVSYLPNSSEYSLGRCKHATEDWGDCGFKTTFFRSATLKWKESLMSRKRPFVGRCCYSCTPQSWERFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYILFVQERDVHKGMFATSVTENVLNSSRVQEAIAEVAAEMNPDGSAQQQSKAIQKVKKKARKILQEMVATVSPGMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGRKDVLYRALLHGHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSSNTIPDILVIPVGISYDRIIEGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGYVRVDFAQPFSLKEYLESQSQKPTSAPLSLEQALLPAILPARPNDAAESEDTSSNEPRNTADEAFRRRLIANLGEHILFTASKSCAIMSTHIVACLLLYRHRQGIHLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLLGNCVTITHTSRKDEFFITPSTTVPSVFELNFYSNGVLHVFIMEAIIACSLYAVLNKRGSGASAGGPGSFISQEQLVRKAASLCYLLSNEGTISLPCQTFHQVCHETVGKFIQYGVLTVAEQDDQEDVSPGLAEQHWDKKLPEPLNWRSDEEDEDSDFGEEQRDCYLKVSQSKEHQQFITFLQRLLGPLLEAYSSAAIFVHNFSGPVPETEYLQKLHRYLITRTERNVAVYAESATYCLVKNAVKMFKDIGVFKETKRKRVSVLELSGTFLPQCNRQKLLEYILSFVVL", "length": 827 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8D1BQI2-1", "protein_name": "Uncharacterized protein", "gene_name": "LCE5A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSCQQNQQQCQPPPKSLPKYSTPKFPGPCPPLVSSCCGSRSGHGRCYSSGGGGCCLSHHRRRRYHPCQPQSSNCCDSGGGQQSGGSGCSHSSGGSGCCSGGCC", "length": 103 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8D1VKI8-1", "protein_name": "Uncharacterized protein", "gene_name": "NCR3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARMLLLILIRVHSGSCALWVSQPPEICTQEGTPAFLPVPSTPARGDWPLALSHGTGTNWPQGRRVVVLGQGVRTGNGTPLVVERGPAQLATPTIFLLRAGFYAFGFLSVAIGSTIYYQGKCHRHMGTHCRSADGL", "length": 136 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I5XVN6-1", "protein_name": "SPATA31 domain-containing protein", "gene_name": "LOC689526", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESFLLLMNSAIESWMNTSTMDIATDLSIAILCGVGLFFLLIPFLKDCPLSPASGNKTDIPKDVKRGRSNTRRKTDVEKGCRDGGKTVEETKTPSQPMKILTRQLLQDSTPQIFWNSSQKLDHLLLSQLFSSLTSLEDLILQKFNRRFWGTSSIFSESVVAMAHVLRNPSFPQQKSVRFSDPCVTDQAPSQAQGLRQQHRYHPRLHRQRKTSLVGMTWVPEKKILPISTPKQIHPCLKRRAYGVSCPTTEKGIQTSLPPECLSHKHGLYSKAVKGYVKRNHQKAIGKPPGNWLRDTLKTKAIRPASILSEHLRMFLHHKEPQTKDKATNVEKQQGTCIRSPPSKKLKQFQGRFPPNTDHYCKRRPQLSQPGQPSILNSKSYKLRKIIQSVLAGMTLMKDRADFSMQSQFSQAPQSSVCNAKRYKYSKRMGSVPRRVPLKKDTARYDMGKPIKKCLGAGTKNVPHSACSILGKRLRARNLALKKGQASVMNPTGNYCLHDSKAEMKLASNNTALPVQCRRTPYLQILEALNPIPPGVLASKLPRIVFPSSPICDFKEEYYSKAATVLKNLHHQDPGGTRVKSTSAASLESALSMCSAAKIQKTQRAPPPAASRGLSKAHTDLLKRHLSIQHSALYFEQGRIIQGTGKGSLQQNTNPQKAKHAPLKSFHEGDSRHHSWNGTMVGPGKRVPPAAAKQTKAVEVKKETPYAWSLGSNESHTGKDINISPRVFGSLGAKRSPGHLQTCTPQHSQDSTLRTQGHRNIILCSNKQPQPRPGRHDPECPSTVHPAKVNLSSEHSMSSFQNTCQKPKTAQGSCERADTKENRVLKDKIRINHLKDLCPHKERQGSIRPTAISQGGRLGRSRPCSLSSTQLKDTAKTRTSDKRQATSKSSWKSDIREVLKYGYVGSKDIIGQEDTSKKDQPPAVTERTEEDWTGEKAMCNMIAHLQYLTNFLFEIMEDTEWDPSKLQGCEVESLTFQLGSSSDSSEGDDDINQGTSTSTMSFGQTSPEMHNCSFTKTGIGDKTQSEIKAKTACDQHLNQVNRGMFSDQLPMPKEYDLSCRYRGIQHQQELGLPDQTFYQYKLRMTHCPHGGTKGHNYSFGYRKLGDQQQPDFTHKALDPHQSAKEDMGCVSCLSPKGSRPVKHRRTDCFSP", "length": 1151 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5XWP3-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "ENSRNOG00000063695", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQRDMCHMTPYRLLCVLVALALSGCNVAQEVTQVQSTASRQEGEEVTLDCSYETSYVAYYLSWYKQHLSGDIIFLIHQISSSTAEERSGRYSLVFQKSLKSISLVISASQPEDSGKYFCALSDLTQC", "length": 127 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5Y4M0-1", "protein_name": "Large ribosomal subunit protein uL14", "gene_name": "LOC108350588", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEQRRGGSSGAKFRISLGLQVGAVINRADSTGTKNVYIISVKEIKGRLDRLPAAGVGHMVMATVQKSRPQLRKKVHPAMVIRQQKSCGRKDGVSLYFEEDAEVIVNNKGKMKGSAITGPIAKEHADSWPRIASNAGSTA", "length": 140 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5Y5C9-1", "protein_name": "Ribosomal protein L32 like 2", "gene_name": "Rpl32l2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAALRPLMKPKIIQKRTKKFIRHQSDRYVKIKRNWRKPRGINNRVRRRFKGQILVPNIGYGNNKKTKHMLPSCFRKFLVHNVKELEVLLMCSKSYCAEIAHNVSSKNRKAILERAAQLAIRVTNPNDRLCSKENE", "length": 135 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5Y6V7-1", "protein_name": "UPAR/Ly6 domain-containing protein", "gene_name": "Pate4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRNTEPLFDIVINCPIAPQFILKILLFPYPANTNLICNTCNRSENSECKNGTGQCTAPEGGSCSTISIYHGQRHVLSKQMCLGHCEEKPHYNGDFMIYVMCCSKNLCNSF", "length": 110 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5Y7P1-1", "protein_name": "Heterogeneous nuclear ribonucleoproteins A2/B1", "gene_name": "ENSRNOG00000069815", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEREKEQFCKLFLGGLSFETTGESLRNYYERWGKLTDCVVMRDPASKRSRGFGFVTFSSMARPHSIDGRVVEPKRAVAREESGDPGAHVTVKKLFVVGIKEDTEVHHFRDYFEEYGKIDTTEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSGQEMQKAQSSRSGRGGNFGFGNSRDGGGNFGPGQGSNFRRGSGGWESSDGYGSGRGFGDGYNGYGGGTGGGNFGGSPGYGEGRGGYGGGGPGYGNQDGSYRGGYDNYGGGNYGKGNYNDFGNHNQQPSNCGPMKSGNFGGSRNMGGPRDEHRSFPSWKGYNGVFGKQSPLTWIKTHSL", "length": 347 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZKP8-1", "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)]", "gene_name": "Gpd1l2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGATTLRVCIVGFWSWGSAIAKIIGTNVKNQQKFASTVKMWVSEEAVNGRKLTDIINHYHENVKYLPGHKLPENVVAVANLSEAVQDADLLVFTTPHQFIHKICNEITGRVPKKALGIIHMESIDEGPRGLMLISDIIREKIGMDVSVLMGANTAREVAAGEFCETTIGSKVIQNGILFKELLQTSNFCITVVDDADAVELCGALKHIVAMGTNFCNGLHCGNNSKAAVLRLGLVEMITFTRIFCKSQVSTTTFLESCGFANPITICYRGSDCKEAKTFPRIGKTMGNLQKEVLNGQTLQGLKTSALVYQFLKQKGLLAKFPLFVTVYRICYEGRPSTEILTCLQNHPAHM", "length": 351 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZL63-1", "protein_name": "Ankyrin repeat domain 13a", "gene_name": "Ankrd13a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVSDQSRKAAAEGGSSPMVWSRPARAPPGGRADGRGPIVERTTGEGRAGDESRRARTVGFVRGDLGLPKGPAVPQNGGGRVSRRGGLVGRHGAGLGPFRKSGPPPRSVMERLAYFPVRGGSAGSSRFASCQRGRERAGRGVGAAERVPEPVPSPARDPGPPAPPAPDSEALVVRCARHLAARRSPPLALRPVGRAPETPSGGSRLVAGGRSGLGGDLLAMSSARDTSSRFPLHLLVWNNDYRQLEKELRDQNAEALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLHKILEAPDFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSLIFKGGDNWAELMEVNHDDRVVTTEHFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNVAFERTKSGFWGWRTDKAEVVNGYEAKVYSVNNVSVITKIRTEHLTEEEKKRYKEDRNPLESLLGTVEHQFGAQGQDLTTECATVNNPTAITPDEYFDEDFDLKDRDIGRPKELTIRTQKFKATLWMCEEFPLSLVEQVIPIIDLMARTSAHFARLRDFIKLDFPPGFPVKIEIPLFHVLNARITFGNVNGCSTAEERQSVEGTQAECAASDATNFEVDQSVFEIPESYHVQDNGRNVHLQDEDYEIMQFAIQQSLLESSRSQDLSGPASNGGVSHAHSYEAQYERAIQESLLTNMEGRCPGGLSDSSRFDSDLRLAMELSAKELAEQELRLQEEEAELQQVLQLSLTEK", "length": 809 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZP24-1", "protein_name": "Large ribosomal subunit protein uL30", "gene_name": "ENSRNOG00000064315", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEAVPEKEKKVAAVPGTLKKKKVPAVPETLKKKRRNFSELKVRRLRKKFALKTLRKARRKLICEKAKHYHKECRQMYLTEIRMARMARKAGNVYVSAEPTLAFVIRIRGISGVSPKVREVLQLLRLRQILNGTFVKLSKASVKMLRIVEPYIAWGYPNLKSVNELIYKRGYGKIRKKRIALTDNSLMARSLGKFGIICMEDLIHEIYTVGKHFKEANNFLWPLKLSSPRGGMKKKTTHFVEGGDAGNRETR", "length": 251 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZPV0-1", "protein_name": "ATP synthase peripheral stalk subunit F6, mitochondrial", "gene_name": "ENSRNOG00000066253", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIVQRIFRLSSVLPSAVSVHLRSNPGVTAVAFNKEPDPVQKLFVDKIREYKTKRQVSGGPVDTGPEYHQDLDREPFKLKQLYGKGEMDKFPTFKFEDPKFVVIDKPQS", "length": 108 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZRI3-1", "protein_name": "Natural killer cell cytotoxicity receptor 3 ligand 1", "gene_name": "Ncr3lg1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASQSCQRGPENAHMHPKGPCCSALCFLCSLGSSPHGSSLGPLRKCGRRSKPVQSSPEGSRVAEWPDGLLSLLLLLWSLLPSAGGLELEMAGTTQIVFLHEDVTIPCKILGSLHLDLSIVGVIWSLKKDGDESEVFKFYGDQLEAVRPGANVSLLGLEHGDASLYLPRFELWEAGEYQCKVVVTPEKKEGTTRLEVVAHPNMSLSEKPATARGGKEKLIICQLDGFYPEALDIKWMGSALKDSHFQEITEGVVTGPTVKNDDGTFSVTSSLALKPALEDHMYQCVVWHRSWLMPQSLNVTVFENTRDSTHGTVPPTAEVGPPVSEPRSVMIYVTIIGLCILLFSVIVCGLWKWKRLTTSNTGLCLRLDVRC", "length": 371 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZS91-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC134482834", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPTETEEELPTPTPKPSISEEGNFHSQYQVLGTSGQGGNGKVLLAHNRLTGTPVAVKVLRKDKQWFQPAMMEANIMRKINHPNIVSLIQVIEKETRIYLIMELVEGQELYQYIRESGHIEEDEARQIFEQILSAVSYCHGKGIVHRDLKLDNIMIDKNKKVKVIDFGLSTQFPPGKMLNHHCGTHSFGSSELLLGHRYDRPKNDMWIIGVVLYCMVVGKLTFDSVIIQDLQRQVVAGVYPAPCGVSKELEDLLSKLLRVNPNFRPTARKAMKHPWFKEHWNGLIVPYEELLPLTPDPAILDAMKSIGLQASVVKHTLKQRKYNEEMATYFFLQKQALQGDGCTAQAQQVSPVAAPFPSLDPAAAFRLEPKRSGSLPVLGTLRVSSSHGHVSHYGQNAHPKGGKRYTVAGRLRPLPMTPTQDHYHKCAVSVPCIQTTSIFSEKSSNKKIKEDNPLSHRAPLEDKPIPSRVRHRGFKGWTRNIANALIKLCCCMPRRKKPRLGQNRISPQK", "length": 509 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZT61-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC134479845", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDITSIKKTLGSQYRVAFFLGQGSYGSVKLAWHRRTQALVAIKTVEISKNTIRAILSEMTTLELLHHPNIISLFQILVTANQIHFILQYAPGGNLVQLISEEGPLPEEKAKKMFGQIVSAIRHCHSLDIVHRDIKPQNILIDGEGNVKLIDFGLAVKCRPGTLLSRHCGTRGFNAPELVLRQPYDGKSSDVWSLGVLLYFITTGYFPFRGNTIDEIEQKITTGTYTVPHHLSGQLENLIHQIFTVSPEMRPSIEEIENHPWIKKCELKIPPMSDPDYKIIEMLCGMGYNAKDILESLQKKRYDEPMGAYLSLKNHVSEGYDLASITPTKPGDPCPPPPPSPAHPSVFGLPLRRRASEPNFGLLHRQPSREQNPLDLILSGLNMGRCVSMPPIAVYYPKKQRSTSTRALHSRPVASPCVYNNMLGVEIILPHKQDIEMNTSSPPQTMGWFKRLRKGIGDCFSRLCCFPRAPKKKTQHRSSKRVAPLKKAASSTI", "length": 493 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZXB5-1", "protein_name": "Uncharacterized protein", "gene_name": "Pilrb2l2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "TALLSSLPGRNLAMARLLLLLLSAACLHTGNSAGYQEKNDFGVDQPDVLSGVQGGSIEIPFSFYFPWKLAKDPQMSIAWRWKHYHGEFIYTSTRPFIHEHFKGRLIMNWTPGQTSGVLRILNLKENDQATYFSSVFLQTPEGMKLWQSIPGTKLIIHALDTTMRSPSIIPSVVPTDDLEYTQGQRNPSLLNLGAMVGMVMAKVVVIIPLYGWMIFLWWKQR", "length": 221 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZY57-1", "protein_name": "40S ribosomal protein S26", "gene_name": "LOC134478821", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSPGPRRPRQEAGSKPRELQQRVLASVKRRCLFSSLGSNTTKKKRNNGRAKKGHGHVQPIRCTNCARCVPKDKAIKMFVIRNILEAAAVRGISEANVFDAYVPPKLYLKLHYCVSCAIHSKVVGNRSCEARKDQTPPPRFRPSGAAPQPPPKPM", "length": 154 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZYE5-1", "protein_name": "Oligosaccharyltransferase complex subunit", "gene_name": "Ostcl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METKHSALLRTFPFLVLECPNLKLKKPPWVHMLLAMTMYALVVVSYFFITGGIIYDVSIEPPSVDSMTDEHGHQRPVAFLARRVNGQYIMEGLASSFLFTMGGLGFIILDRSNTPNIPKLSGFLLLFDFVCVLLSFFIARVFMRMKLPDCLMG", "length": 153 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZYN2-1", "protein_name": "Non-selective voltage-gated ion channel VDAC2", "gene_name": "AABR07051831.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAECCVLVCPRPMCIPPPYADLGKAARDIFNKGFGLGLVKLDVKTMSCSGGEFSISGSSNTDTGKVSGTLETKYKWCGYALTFTEKWNTNNTLGTEIAIENQICQGLKLTFDTMFSPNTGKKSGKIKSAYKRECINLGYDVDFDFDFGWLAGYQMTFDSAKSKLTRNNFAVCYRTGDFQLHTNVNNGTEFGGSIYQKVLCEDFDTSVNLAWTSGTNCTRFDIIAKYQLDPTASISAKVNNSSLIGVGYAQTLRPGVKLTPSALVYGKSFNAGGHKLGLDLELEV", "length": 284 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZYX3-1", "protein_name": "Methyl-CpG binding domain protein 3 like 3", "gene_name": "Mbd3l3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "LGELGNAGRLTGSMIPSRLQKRRKIQVAKSKRKAKHKSGTTLRNPLRLTSCIFPQPVTVITSYPENKTRYRRDEAKLKKPQQLCALERLKNFQFGGDSKENLSCPLELANAVERIARGMQDEASNQSGDKDQLTSGQVTSDQPPYLETNEHVALQLSPSFSSQGVTLPVPLHLSPSYFLRKVTTGDIQRQAWKVKKARKRLAEALEADRLARQTENMRE", "length": 219 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZZU9-1", "protein_name": "Keratin-associated protein", "gene_name": "ENSRNOG00000070302", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "SPSTCELSSSLHSDCQETCIEPSICQRSCVASSPCQMPCYYPRSSTACSPCQGTYDGSMGVGSNSLKSFGGFTGSLGYGNSGFGSFGFGSCGIRSQGFGCNFHRPGYFSSKSVQSSYYQPGYTSGFC", "length": 127 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZZY5-1", "protein_name": "Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein", "gene_name": "ENSRNOG00000064452", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTKIKAVTEESEAQGEGCSQQHRYQELLVYLNPIAQHPGFPPPDLRKIEKGKKKKKRRPTKQKQIRHGVKEVQKFVNKGKKGIMVLTGDTLRGTAIFQLCARTRICPTSIFPLTDLGAAMGSKHPTCVIMVKLHEEYHEAYDKCLEEVQTLATPL", "length": 155 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A2Z7-1", "protein_name": "Developmental pluripotency associated 1, pseudogene 1", "gene_name": "Dppa1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMPPQVLISGLLLLLPAAWTTTVTSSDQLWNNHTEVVPTQSPLKISTKDLYIGTSVSAALLILLAGVLAVLKYRHRRKKILESAVVFHGFQNGVFQSTEQSQAVDVYVIEDSKVPVAH", "length": 118 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A3D9-1", "protein_name": "Small nuclear ribonucleoprotein Sm D3", "gene_name": "Snrpd3l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSIGRPIEVLQEAQGYMVTRETITGEVYPGKLIEAEDNMNCQMSNITVTYRDGPVAQPEQVYICDTKIRFPILPNMLKNAPVLENLKNKNQGSRAGQGKAAILKAQVAARGRGHEMGPWKLPEAKTVFSIKENFPSCLLLGF", "length": 142 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A3N0-1", "protein_name": "Uncharacterized protein", "gene_name": "Pramef20-ps2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTVQTPPTLEKLAIQSLIRNEDVAMSSLGELPAVLFPALFKEAFTGKHINLVKEVVAAWPFPCLLVGALMKTPNLETLQAVLDGVDMQLTRKFHTRRTKLQVLDLRNMHHYFWNIQAGEEDSSCSAENSKEKKVVKVFHRYALRKRVKVIVELYIHSCLKEEQTCLLKWAQQRKGSLHFCCTKMKVWNLSLCGIGEILKVFDPQHITELELHTEWTLLELAHFAPYFGQMRNLQKAFLAPLHRIMFSNSNGKRDREAKCIKKFISQFSKFNCLQHLHMFCVHFLRDHMNQVLGCLMTPLTLSITYYLISQKDLDSLSRSQSLFQLKHLDLRGVVLCDLDIMPLRGLLEKVADTLETLDLQWCKMTDSQLYALLPALRHCCQLTMVNFYSNNFSVPILKDLMQHIANWSRIRVQQYPAPLECYDDLAQVSVKRFAKLSSELMYTLGVIRQTKNISFATDICHTCGQRCVYHNGSRLCCCWH", "length": 480 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A3R7-1", "protein_name": "Ubiquinol-cytochrome-c reductase complex assembly factor 3", "gene_name": "LOC120093241", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEAARKALTVVAVLGSGAGVGSILFALVTPGELQKQLMLQEMPERDSRRRDAAVRTKELVMATLKDAAATKENVAWRRNWTVRGDGRSA", "length": 89 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A3T5-1", "protein_name": "Large ribosomal subunit protein mL62", "gene_name": "Mrpl58", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "EHGGRLGPTLEPEPSWNLVAPAARALCSPDSAQTGERHRVQEHLQPGQAVPRIQGRGYRLEGPGEPRKAGRKGRFLLLLDRLSISYCRSSGPGGQNVNKVNSKAEVRFHLASADWIAEPVRQKIALTHKNKINKAGELVLTSESSRYQFRNLAECLQKIRDMIAKASQVPKEPSKEDAQLQRLRIEKMNRERLRQKRINSTIKTSRRMTMD", "length": 211 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A478-1", "protein_name": "T-cell activation Rho GTPase-activating protein", "gene_name": "LOC134485907", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGEIHRTLLCQGPVELTSGRKRNKRYLSLFDDVLVVSTNLTKKKFKIKCIIPLNYLWVVDDVELVRANQTCTCKTIFFYWATGNALATFRSKEQKVQWYTFLTRSINEAKKGIKKTFPLHIFPEDIQTCDSSLCVTATNMDTVNDIMEKLLPMIRVHNIEDYQLWFSPGHKETPRALQGHEYPYDIIMNNVQNNLSKSNSKIFTAFPPLPGLFMENQSWDTGGQFILKPRDSAGSQQQDAKERPRKSCMTSCFHGGSVPHHDQECSDPRDDKRGKLFGQDLSSICQDGKLPTIILDMLSRIKDKGPTTDDIFLITPNGSLCKTIKEKLDNGENVDIYQQPVHVVAWILKEFLQSIKGSLLTSKLYDQWLIVPEKVNDKEKLAAVKSLLEKLPKPNADLLRQLFRILHQIKTNSSVNNMSSFRLSLETAPCILWLPSYRNNILTNDIAKKISLVTFMIDNSPELFGEDIVAVWYETSLYHPPGLKYPCSQNTPSSNGIMEETEHGLSSCPGERTCTPDFDELPRSGAAASIPYEGILASEKGEGNESTTQPEPVQNSPTPQTKKELGNCSPNILKDVNVPAVILDMLSVIAEKGQCSDDIFRMQSEKSHWSLKEKVNTGKHVNLKEESVLTVASVVKDFIKNIEGSLLSCDLYENWLSIPDEGPLLGKIASIQNILLKMPKPNYVLLKQLICVLQKIKAASTNQLDTFDLSVRIAPHVLWNPTCKTLFGRDLSKKLSIIKFMIDNCQELFGENDNIFCEDNQKSYDINLSSDTLNTSGKATLMIETIDDHDVKTSKSNTKKLEMSSAVPHEGGPTAGHNGTTSKYNVPQEKILHD", "length": 834 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A4C1-1", "protein_name": "RRM domain-containing protein", "gene_name": "ENSRNOG00000063783", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "LTCCAINSDPHPDSGLKMEGHDPKEPEQLRKLFIGGLSFEATDDSLREHFEKWGTLTDCVVMRDPQTKRSRSFSFVTYSCVKEVDAAMCAQPHNVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIKTMEVMEDRLIDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGGSGNFMGRGGNFGRGGNFDGRGGYGGGGGGSRGSYVGGDGGYNGFGGDSGNYGGGPGYSSRGGYGGGGPGYGNQGGGYGGGGGGYDSYNEGGNFGGGNYGGGGNYNDFGNYSGQQQSNYGRMKRGRFGGRSSGSPYGGGYGSGGGSGGYGSRKF", "length": 350 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A5E5-1", "protein_name": "Paired immunoglobulin-like type 2 receptor alpha", "gene_name": "Pilrb1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQILLLLLSATCLHTGNSGGYTRKNYFGVNQPAVLSGVQGGSIEIPFSFYFPWKLAKDPQMSIAWRWKEVHGEFIYQSTLSFIHEHFKDRLILNWTQGQTFGVLRILNLKENDQATYFSQVCLQTTEGMKCWQSIPGTKLIVTHGVICSLLISPQLSYDHEDPLHHHLCRPHSWPGEHKGPKESFTAEPGGHHWDGRGQSCSHHPPLRMDDLSVVEAKASRVTPKPQPE", "length": 230 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A5T5-1", "protein_name": "Large ribosomal subunit protein eL21", "gene_name": "Rpl21l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTNTKGKRRGTRYMFSRPFRNHGVIPLATYIRIYKKGDIVDIKGMGTAQKGMPHKCYHGKTGRAYNVTQHAVGIIVNKQVKGKIPAKRINVRIEHTKHSKSRDGFLKRVKENDQKKKEAKEKGTWVQLKRQPVPPREAHFVRTNGKEPELLERSPYEFMA", "length": 160 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A8T3-1", "protein_name": "Olfactory receptor", "gene_name": "Or1o11b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "RMNCSQAPGFILLGLSRDPEKWQLFFSVFLVLYLLGLSGNLLLLLAIGADVHLHTPMYFFLSQLSLVDLCFITTTAPKILQTLWTGDGSISFSGCLTQLYFFAVFADMDNLLLAVMAIDRYAAICHPLLYPLLMTPCRCGVLVSGSWGVAHCVSLTHTLLLSQLYFHTNQMIPHFFCDFGPLLLLSCSDAHLNEGLMMALAGVFGISALLCIVSSYSCIFYAVARVPSAQGKRKALATCSSHLSVVLLFYSTVFTTYLKPPSSSYSSGEVVAAVMYTLVTPTLNPFIYSLRNKDVKSSLRRILNMVKSPD", "length": 310 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A969-1", "protein_name": "Uncharacterized protein", "gene_name": "ENSRNOG00000067430", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFFLFWTFPGLELDKLALLSFESSSSIHPRACASTPAFQRSHNPGDAAQQEAKQREAEMRNSILTRVLDQSAWVRLSDLALVKPDKTKAVEHRVQMARYGQLSGTVSEQGFIETPEKVSQQTEEKATVKFNRREVTDSDEDDDY", "length": 144 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A9H4-1", "protein_name": "NAD(P)(+)--arginine ADP-ribosyltransferase", "gene_name": "Art3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGQATARGVIKRKAFPGRQLSLSTTSCPGGKITPAESGNRFESGHHLNVLQRHKRQKRKMKMGHFELVTTLLAAMVLMDVFQVQAEVLDMAENVFDDEYLKCNSRMEMKYIPRMHGEELANDELLQSVWDKAGIQWEAQKAQLSLPKNFKDAYGIALTAYVTEAQDQSPFYHTFNRAVKIAGLSRRRYIYNFPFKAFHFYLVRALQLLRRPCEESYKNVVYSTSPNISFAFGEQNQARLGNFTLAYSAKPQTANEQRLLTIQTCFGVAVGKLLNKESEGIVLIPLSEVFQVSRKGTDDDLILHSINSTCSYYECSFLGGLKAGSCTTNPENPDPGYLNNPDLDSQKLEDSGRKSLDSVKMPEIKVLQGEENPLLPDEKPEDRNRGKANVPTPGLVPVPGPKSHPSSSSGHRLLPSDTASTILLIAAAVDFIAL", "length": 433 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AA84-1", "protein_name": "Ankyrin repeat domain 10", "gene_name": "Ankrd10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAGAGAGVEAGFSSEELLSLRFPLHRACRDGDLVALCSLLPHTPRAHLAAEDSFYGWTPVHWAAHFGKVGAGTLRRHFPRGVLLGSERTPPCLESAATARSAPPAPPEGSRAHVQQSGLGVKGWGRGGAEAALAPPGVQGACAAARSPGPRGARGVMGGGAEMGSVWPAPRRTQGACAHLWLFRAGRADRMQLRRFARRPSGFGEWCGRLLLEARREPGASRSCLMETGRRAPLRHKGMDAALAAGGVRSAPAVVDGGLAARPTGPLSQLGPPCLECLIQLVRAGASLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVGNGAQTDLRNASGLTAADIAQTQGFQECTQFLLSLQNHQMSRFCPNGTLSGGHENILPNHINLGTNRKRCLEDSESLGVKKARTRVPSLDHTMPLANGDAEDDADRMHVDREFAAVSDMKNSSSVLNTLTNGSVINGHLDFPCVAQLNGMESRSDPCLTGSNGISNGQPFPSGQGPVCANGTEEPEKTMGVNPEMCGSLHLNGSPSSCVASRPSWVGDIGESLHYGHYHGFGDTAESIPELSSVLEHSSCVRVEQRYDSAVLGAMQLHHGS", "length": 621 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6ABF4-1", "protein_name": "Nuclear transport factor 2", "gene_name": "AABR07018058.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGDKPIWEQIGSSFIQNYYPLFDNDRTQLGAIYIGASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSIMAQQYQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMFRLALHNSS", "length": 127 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AC04-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vom1r38", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSMLSQNKTLKSIEEVALHVILLCQVGVGTVANFLLFIHNFSVILTNCQLTPIQVIVTNLAVASAFNLLLLAFPNNVTLFVPRKAPSDLSCKLWYFICLVARSTNLSSTCVLSTYQFVMLLPGNWSRVILKGRAPKIVNYSCYGCWIFSVLNNAYIPVKVSGPQKTQNDTDFKDKWVCSTSGFSVGMSFLRFAHDALFISIMIWTNVSMVILLNRHHHRLQHIHSSNQDHRAYADTRAAHTILMLVVTFLSFYLLDCICTFFHISFVDSRLLLRRIKEVLTASFPTISPFLLIFRGPKNPCSLLSRS", "length": 307 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AC51-1", "protein_name": "Non-histone chromosomal protein HMG-17", "gene_name": "Hmgn2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKRKAEGDAKGDKAKVKDEPQRRSARLSAKPAPPKPEPKPKKAPAKKGEKVPKGKKGKADAGKDANNPAENGDAKTDQAQKADGAGDAK", "length": 90 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AC66-1", "protein_name": "Eukaryotic translation initiation factor 6", "gene_name": "Eif6-ps1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVVRASFENNCEVSCFARLTNTYSLVAIGGSENFYSVFEGELSDTIPVVHASIASCRIIGRGTSVWGTGMGYWYPTTTTDQELQHIHDSLLDSVQIRRVEEGLSALDNVTTCNDYVALVHPDLDRETEEILAGVLKVEVLTVADQVLVGSYCVFSNQGGLVYPKTSIEDQDELSSPLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVVESVFKLNEAKPSTIATSMRDSLIDRLT", "length": 245 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6ACC5-1", "protein_name": "Uncharacterized protein", "gene_name": "ENSRNOG00000069094", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "LPLLAFEKYVVCDGELQRLQVSCEVLGDVDPPQRLSASVVQMKQSVVEFLGTLVEQDAQGAAEDMDNALVGDNEEAEGENNSTRTNSDGPFTERPNQRLNNR", "length": 102 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AEL7-1", "protein_name": "Protein phosphatase 4 regulatory subunit 3C like 1", "gene_name": "Ppp4r3cl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEDKLYRVKVYVMMEDKQWKDIGAGQISSKYIDRLQGVCLLVHSESDGSPILECKIQPNVPYQKHQGKVIIWSEAKNHGTAIHFQEPNDCQETWEVICQVQGKDPNVEITQLLTDDLESFKDMLLSWNKVEMSSCELHTLENIADLLSFVNEAPSHKKILTLVLEKEGYIKKLLQLFKTCEKHQNIDGLHYLNNIIRGILFLDNIHLFNIMFSDEFIMDVVGCLEYGPGLDEPKQHRQFLTQNVKFKNVMQITHSQLRKKIQQTYRMQYIYDIVLPTPSIFEVNLLHDLSTMIFFNKIEIITMLQEDEHFLLEVLAQLKDNTVSNERRHELLLFFKEFCAFAKTLHFQKKNTLLKTLIKLGIISALKVVVHMHDYQIQVAALELFAHLVEYSPRLIRAYAMKEAQYSEDNDGLLINIMIKQMTCDSDPEFSRSIILTTVLHAILDPENMRVTTKGHERRKFLNYFYRHCMNKLIEPILSITVENNSDDNRVNICPDNYQNAQLLGAILEILTFCVQYHSKYVKNYIISKNLLSRILILMSSKHTFLILCAVRFMRKMIGLKDKMYNLYIVEKNLFEPVVNAFMHNGHRYNMLNSAIIELFEFIRQENIKSLIANIVEKFFMFFESIQYVQTFKGLKTKYEEEKKKKRERQLRKSLHNIIYQRIYCRHIKAMEVKVKADIFCRQITDKEEEREKGGGGGEGGGGRGGEGEGGREGGGREGEGGGGGKGGRGEGGAVLSMGSDIPSHYDMFVKINEMNERENVIECRKRKSSATSEYSTSCGDTSDNGISTVYCSSLVPLVDYAYDTDGEDDDGSYGNNENEEEEEEEEEEEPPKKKPYFHP", "length": 840 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AFG0-1", "protein_name": "Cytochrome b5", "gene_name": "ENSRNOG00000064959", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFAKEKGKFEDMAKDVKCYTLGEIQKHQDIKNSWAMLHHRVYDLTKFLEEHLGEEEVLRERAGGHASENFEDVGCSTNVQGLSKVHIIGLFHPALITTIKLNSNWWDQLCSPTSQVVVAHTFNPSTREVGAVGFP", "length": 135 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AGM4-1", "protein_name": "Proline rich 18", "gene_name": "Prr18", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRLLGRVMSFSPMPPPPPPPPPPARTQGGPAARQLSRRPCGPPAASPPAPAAAAAGEKKRRPPEMLLSSSWPSATLKRPPARRGPGLGPGTPQPPTSARVPPQPSPGRGGTSATCSAPRRIACSHIPAGSTASGTSAGAGAGPEDATRFSLSLTPEAILVIQRRHLEKQLLARPRRPFPAPSADPRRPLVPCPRTRSSTLRRGGPTSVPDAPLAVAVSSRPPRASLLPGGLQATMPSPRPSSLRPVLKVSLLNEKHKYDDEEYEEEVEVVDEGLVRKCTEWLRGVESAAAARGRTGHLDSLPHLSTL", "length": 308 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AGS9-1", "protein_name": "Olfactory receptor", "gene_name": "Or5aq7b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVWNSTGVKEFILIGLTENPNWQVPLFLLFCIIYFIILVGNCGMIFLIWLNVQLHTPMYFFLSNLSFCDICYSTIIAPKMIINFLSEHKSTRLFACILQSFFFAVYATTEVVLLSMMAYDRYVAIANPLMYTVIMTQSICTQMILASYLTGLINSLIHTIGLLKLNFCGPNIVNHFFCDVPPLLKLACSDSHINEILLLVFSGIIAISTLIIVIVSYIHIIIAILRIRSAMGRGKAFSTCASHLTAVALFYGSLTFSYIQPSSQYSMEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKEAAQKLMLGKRNAC", "length": 312 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AIA3-1", "protein_name": "Uncharacterized protein", "gene_name": "ENSRNOG00000065493", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIFVPFFPHPGSIRKDGVVYAHTMENSSNSPRETREPAPLRRTWRGCFQRALPRVSKFFRRGRGSTGGWDNGSPRQGPMHSDQDLRHLRSLLSKESCPVMSK", "length": 102 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AK52-1", "protein_name": "Olfactory receptor", "gene_name": "Or9s14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAIEVHRNGSLSAMSLQGFVLLGFRGGAETQALLFTVFLVLYVVTVLGNLTMIMVITLDARLHSPMYFFLKNLSFVDLCLSTVVVPNALASIFFSSKTISFAGCATQFFFFSLLAATEAVLLAVMAYDRFMAICSPLRYPVTMCPMTCVRLVLGTFCVACLNSIVQTSLTFRLPFCSSNRIDHFYCDVPPLLQLACASTALNELVMFGICGFIIVCAVFVVIISYVYITVTILRMHSGSGRHKLFSTCGSHMTAVSLFYGTGFAVYGQPGGVASMEQGKVVSIIYILIIPMLNPLIYSLRNKDVKDALRRLGQRHSLAKESG", "length": 322 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AMC4-1", "protein_name": "Retinoic acid early-inducible protein 1 domain-containing protein", "gene_name": "ENSRNOG00000068014", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCVFKNAWGHRNMCSMALCSQFGTHLHVSLTDAHSLSCNLIIRSPTKAEPLRYEGHCSMDEIVFLSFNNVNKTMPLGNQEKMANATKVQKCLTQWIDLLGQDLRDKVSEIKVHTTKTSGHPTLRVTMLSKHRHGEIIGASWEFNISENYSFILDLKTMKWKPQDIMKEWKDDETLMKHLNLSIVECSQKFNEFLNQHEERTSRYYLDSALPPAPPPLFKGFTILLWHSYTPAISPTSSDTHSSFINFRDGLIDINFPL", "length": 258 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AMN7-1", "protein_name": "60S ribosomal protein L7a", "gene_name": "ENSRNOG00000070681", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPGYITLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLACAEKKAAGKGDVSTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVLYCIIKGKARLGRLVHRKTCTTVVFTQVNSEDKGALAKLVGAIRTNYNDRYNEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG", "length": 266 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AMX9-1", "protein_name": "Ribosomal biogenesis factor", "gene_name": "Rbis", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKNKLKGQKSRNVFHIASHKPLKAKNKAKPVTTNLKKINIMNHEKVNRMNRAFVNIQKELANFSKSLSLKSVQKELHHEKEPANVDEATRLMAQL", "length": 96 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6ARJ3-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "Or8b101l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTLGNVSSVKEFILLGLTQQPELQLPLFFLFLGIYVVSVVGNLGLIVLIVLNPHLHTPMYYFLFNLSFTDLCYSTVITPRMLVGFVKQNIISHAECMTQLFSFCFFVIDECYILTAMAYDRYAAICKPLLYQVTMSHQICLLMTVGVYMMGFVGAMAHTGSMLSLTFCEGNIINHYMCDIPPLQKLSCTSTSINELVVFTVVGVNVIIPTLTLFVSYTLILSNILSIHSAEGRSKAFSTCGSYIIAVSIFFGAVLFMYFKPSSASVDGDKVSTIFYTILGPMLNPFIYSIRNKDVHVALRRTLKKRIFT", "length": 309 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6ATM0-1", "protein_name": "ELAV-like protein", "gene_name": "Elavl3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKDAGAGSCRYKGLGAAAVRPRARSAQRGPVGGREGGREERTHYPAPDRPDRGPAAEGRAAEISVGKSDFCGPRGAALRAPSTARPLPPSTCRQGSGRRSAHPQARVSSRPSRAPPPPSSPLRRPQSQTPGRDPGVSTRRPPRSARPPEPPSIRTAPAGHTRMVTQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILLDQATGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKRFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQHKA", "length": 522 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AUS4-1", "protein_name": "Ubiquinol-cytochrome-c reductase complex assembly factor 3", "gene_name": "ENSRNOG00000062467", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQTAAGKTLAVVAVLGAGAGVGSILFALVTPGELQKQSMLQEMPERDSRRRNEAVRTKELVIATLKDAAATKGNVAWRRTGQLEGQGRMCGTKGTNKCSLPIKWISQLDI", "length": 110 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AWY6-1", "protein_name": "Uncharacterized protein", "gene_name": "ENSRNOG00000065059", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKATKKSKNTTSDVEPSTSSAKSKKAKTCYQYQTRAGEKKSRWSGSDCSVNVQKTTKKAKRTLPRIAENNTSEKTVPPTKKTKRAKDEQLFGHYHRLMDEISTSTERGPEQSSTDSSSASTSDEESQ", "length": 128 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6B5G4-1", "protein_name": "protein-tyrosine-phosphatase", "gene_name": "Ptp4a1l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARMNCPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCKATHDTTLVEKESIHVLEWHFDDGAPPSNQIVDDWLSLVKIKFPEEPGCRIAVRCVAGLGRAPGLVALALIEGGMNYEDAVQFIRQKRRGAFNGQQRLPLEKYHPKMWLRFKDSNSHRNNCCIQ", "length": 173 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6B646-1", "protein_name": "Ankyrin repeat domain 66", "gene_name": "Ankrd66", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRSREARLHHQTPGDQEAGAACLLSWGGGGASFHGVNTLTLRPAMMACSTELLKDTDSVMELSKLSDMTKLHQAVAAGDYNSVKKILKKGLCDPNYKDVDWNDRTPLHWAAIRGQMEVIHLLIQYGARPCLVTDVGWTAAHFAAESGHLNVLKTLHALHAAIDAADFFGDTPKRIAQIYGQKDCVDFLDTAEPECRDHRQRGLLFDERDPDWDLKKRELELSLPVPDQNTNKKKKRIRGSTRVNHSKAWRI", "length": 251 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6G1V0-1", "protein_name": "Ankyrin repeat domain 62 like", "gene_name": "Ankrd62l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRVAGLSSKKSRWLLQSLLDQQRHSLGTGFESANILLSPKYHLKDKDLRKIHKAARDGDAARVQQLLLGKHCVNDKDKKKRTALHIACAYGHPKVVMALVEGKCEVNATDSEECTSLVKAVQCQEEECATILLENNADPNIVDAQGNSALHYAVYYKNTSLAAKLLDHEVNIEATNKDGFTPFLLAVSENKLKIAKFLLMKNASIHAADNQKRTALMHAVSHDSTNLVRFVLEQGVDLFVKDAFGLTAIDYAADFKYNSNMEILLEYKAKRYEESERANLVEKSSEEDSSRRKDQQSQELENMEKEELTEPGNGTEEQEPDGGVTSVEEPRRLDDRGDDQPQEAVTAPRTREKEQELPFTDMCTVVTGKEDEDESSWDSESVSENLPLIRIGVDGLLLVNGQAVENPEKYLHWLHNRKGEESVPNETKGVGDLQAFTPAEPGLELTSEEKHEELSRNEDCQPQVEEERTQEWSGWGAPEALCAAALDHGDIGSPLTRENGHPRARQSPSVDSEEQDGGSGLNIKEEKTRDHEEWSGDFLMDRTSKESEPAAGDLLQVKDSWSLNDTDPNKGSPAKRKSKEKHKVRGEMNAMEDADDFTPLSESCSDNKAELCCNTHQAETETESCELLTRQTGNMEGGVAGEVLKTEPARSREALKETEETGEGARVKMQLPGKDELYSEDAERQQYDMALSALHLKTKQTVRQLQETQDRQREVVRSSQRMQDHLQKLQAGCSEAEAMVQEQGKKTAELQKLHAGMIHELKEKWETIASKYLPLNIQLKYLEQELLSIKIAQKQYEKLHEDQRTLQRDAVDLQHQVQENMAKLDDEKQAMALRDSNNDSLMSQVELRIKNLESNLQKLQAEKESNERNVEKYLQRYIRERELSKTLSHTLHRTNSKLSRVRTDILLVTERNRTVQNTLTTRPVPKSPGVTEHSAYVNRNPNFIASRNLEAAMSSPQPSPELMRRRLLKKQKNMVKNITEEVDKAAAELESWSLEAYPSGSK", "length": 1003 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6G430-1", "protein_name": "Large ribosomal subunit protein eL24", "gene_name": "LOC689816", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLETCRNLSAIGYIWEDNSTEEYCKSSRRHGRPTSVTMKVNLCSFSGYKIYSGHERLYARTDGKFSSFLMPNVSPHSFPKGTLGKLTGLSSTEENTRKDSRKKFKRKEPTLQKFQRAITGASLADIMAKRNQKPEVRKAQQEQAIRDAKEAKKAKQASKKTAMAAAKAPTKAAPKQKIVKPVKVSAPRVGGKR", "length": 193 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6G808-1", "protein_name": "Paired immunoglobulin-like type 2 receptor beta", "gene_name": "Pilrb2l7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARILLLLLSAACLHTGNSAGYPKKYDYGVDQPAVLSGVQSGSIEIPFSFYFPWELAKDPQMRIAWRWKVFHGEFIYNSTQPFIHEHFKGRLIMNWTQGQTSGVLRILNLKENDQATYFSRVFLRTTEGMKSWQSIPGTQLIIHALITTPGSPSIIPSAVPTTGLEDTRGQRTPSLLNLGAMVGMVVSKVVVIIPLYGWVIFLWWKQRTQFRRDLVSEHPWKNFVPILPAESSSFL", "length": 236 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GB91-1", "protein_name": "Olfactory receptor", "gene_name": "Or4c117b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "TNRYYFNIFMIIMQNQSFVTEFILLGLSQNPNVENILCVVFLFIYLATIGGNMIIVVTIIYSPALLGSPMYFFLIFLSLLDACTSSTVTPKMIVDFFYERKTISFECCMTQLFAIHFFTGIEVIILSAMAYDRYVAICKPLHYSSIMTQRLCGILVIVSWAGGFLHSIIQIIFTLQLPFCGPNVIDHYLCDLFPLLKLACTEPHIFVILVFSNSGSISIIIFSILLVSYGIILFSLRAHSSEGRRKALSTCGSHITVVLLFFVPCFLIYARPTSAFSSEKNAFVFATIITPLLNPMVYTFRNKEMKNAIRKMWKRLIMVSCNY", "length": 323 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GF85-1", "protein_name": "Ceramide-1-phosphate transfer protein", "gene_name": "ENSRNOG00000064148", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "HFFLEYLNNLKIMLIFLSPPTGGWASDHHSPTTGTHLRFLNSLGAAFSFISKEVVSKLQIMEHPRSSPQSEHCSSLQSMAAYEVSNKLLDLARRSGPLHSNSGCRTVLCLHRALHWLQLFLEGLRTSSEDARTSTLCTEAYSAMLCAYHSWIRQAVTVAFCALPSGKVFLEMLGEALPFMEQMCDISQFYVEHFLLDLP", "length": 199 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GFV7-1", "protein_name": "Olfactory receptor", "gene_name": "Or1f21c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSTNQSSVTEFLLLGLSRQPQQQQLLFLLFLTMYLATVLGNLLIILAISTDARLHTPMYFFIMILSFTDVCFSSTTVPKVLANYMLRSQTISFSGCLTHLYFLCVFADMDNFLLAVMAYDRFVAICHPLHYTTKMTNKFCVLLIVGSWVLTNLNALLHTLLMAQLSFCGDNIIPHFFCDATPLLKLSCSDTHLNDLMILTEGTMIVVTPFFCILISYIHITCAVLRVSSPRGGWKAFSTCVSHLAVVCLFYGTIISLYFNPSSSHFAGKDMAGAIMYTVVTPMLNPFIYSLRNRNMKGVLRKVLILRFPSKQ", "length": 313 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GGC1-1", "protein_name": "Histocompatibility 60b like 1", "gene_name": "H60bl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKGATSKCNHSLTLSLLVLLNSLGTMQVDGTDSLSCNFTVQYKVSLGQCSVNGMTVLCFDDVRQNSPVCKTEKKGNATKLCNDLNQCLSYSFYEMMKLESGLFESKGNHTLRVTVQSQYNQGEFMDGCWAFMIDRQYPFYFYPKNMTWRENQPNAIKTMSQWENNRELFQSLKFLSTGDFSLCLKKLLTDSRELTRSTIKAPDTTQPTSTTQSPSTGNSTPAMSSNQSPSTGNSTQPTSTTDYLIVFEFTAIFLALIVVSMEKKKVLPAAPLPLQYELQSPSPAVLEES", "length": 290 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GIM2-1", "protein_name": "Olfactory receptor", "gene_name": "Or4x11c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADLFNVTEFIFLGLSPNKEVQRVCFVLFLLLYMAIVLGNLLMVVTVAVSRNLGSPMYFFLSSLSFVEICYSSTTAPKLILDLLAEMKSISVWGCMTQLFFLHYFGGIEIFLLTVMAYDRYVAICKPLHYTSIMNRKVCIVLVGTAWTGGFVHSFAQIVLIFPLPFCGPNTIDHYFCDVLPLLKLACSDTFLIGLLIVANAGTLSVIIFVVLLASYVVILFHLRTLSAEGRRKALSTCGSHVTVVILFFGPCVFIYSRRSDTLPVDKMIAVFYTVITPLLNPLIYSLRSAEVKKAMKNLWFRTMKADEK", "length": 309 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GJN1-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein A1", "gene_name": "Hnrnpa1-ps20", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "LSQSPPRNRTEQLWKLFIDGLSFETTDESLRSHFERWGTLTDCVVMRDPNTKRPRGFGFVTYTTVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGSIKEDTEEHHLREYFEQYGKIEVIEIMTDRGSGQKRGFVFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRNGSGNFGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGSRSSGSYGGGGQYFANPRNQGGYGGSSSSSSYGSGRRF", "length": 319 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GJR0-1", "protein_name": "Aspartate aminotransferase", "gene_name": "Got2-ps6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALLHSRMATTFHPGLAAAASARASSWWTHVEMGPPDPILGVAEAFKRDTNSKKMNLGVCAYRDDNGKPYMIPSIRRQRPRLLEKIWTKNAYPSGDWLVFVRLLQRSEPVFCKDILSLAKMSFYPNHPGETTRPSSGMPACSYKVIDTMTHKTCGFDFSGALEDISRIPEQSVLLLHACAHNPMGVDPRPEKWKEMVSVVKKKSLFAFFDMAYQGFASGDGDKDAWAVQHFIEQGINVCLCQSYAKNMGLYGERVGSFTVVCKDEEEAKRVESQLKILIRPLYSSPPLNGARIAATILTSPDLRKQWLQEVKGMADRIISKRTQLISNLKKEGLFHNWQHITDQIGMFFYMIKDGRISVAGVTSGNVCYLTHAIHQVTK", "length": 379 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GL73-1", "protein_name": "Uncharacterized protein", "gene_name": "LOC134481331", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "TALLVSLPEQNLAMARILLLFLSAACLHTGNSSGYRRVNDFGVNQPAVLSGVQSGSIEIPFSFYFPWELANDRSMSIAWIWKYFHGEVIYNSTQPFLHEHFKGRLIMNWTQGQTSGVLRILNLKENDQARYFSRVFLRTTEGMKSWQSIPGTQLIIHALNTTMGSPSIIPSAVPTAGLEDKRGQRNPSLLNLGVMVGMVLAKVVVIIPLYGWMIFLWWKQR", "length": 221 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GLF3-1", "protein_name": "Heat shock protein 90 alpha family class B member 1, pseudogene 13", "gene_name": "Hsp90ab1-ps13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLWELISNASDALDKIRYESQTDPSKLDSGKELKIDIIPNPQERMLTLVDTGIGMTKADLINNLGTIAKSEDQTEYLEERRVKEVVEKHLQFIGYPITLYLEKEREKEISADEAEEEKREKEEEDKEDEEKPKIEDVGSDEEDESSKDKKKKTKTIKEKSIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNAWEDHLAMTSLSGYVSRMKETQKPIYYISGESKEQVANSAFVERVWKRGFEVVNMTEPIDDYCVQQLKEFNGKSLVSVTKEGLELPEDEEEKKKMEESQTKFENLCKLMKEILDKKVEKVTIPSRLVSSPCCIVTSTCGWTANMERIMKARALRDNSTMEYVMAKKHLDINPDHPMVETLRQKAEADTNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNCIYCMIKLGLGIDEDEVTAEELSAAVREEIPPWRVMRMPLAWKKWIKGSWEAPALCIVSLGLPQQP", "length": 518 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GM54-1", "protein_name": "MAGE domain-containing protein", "gene_name": "Mageb11l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPHDQKSKLHSRENSYQAGGGAQAYGDAEEIAEAAAEAAEESSAKSQSQPGAEYSRNHRAPPKAKPSAKLILSSSSSESDESSHEESEPSVQKDRPFLHQDLIERRVAILLQYLLHNYNLKQLTTKEEMLKVITKKYEKDFPEILRKASEKLEDAFAVEVREVSSSQPSYDLISKLKLPNNGRIRAGKGLPKTGFLMSILGIIFIQGNSASEEDIWKILKKKRIYPGKKHRVFGEPRKLMTQYLVKLKYLEYRQVAHSDPPRYEFLWGPQAHAETSKMKVLEYLAKINKTTPHAISALYQEALKDEKERAEVRDEDNTDTTDQSTEGSPEKSPTASTTPVDT", "length": 342 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8J8YII4-1", "protein_name": "Coiled-coil domain containing 188", "gene_name": "Ccdc188", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGPEPLGPCGHSHTQHPPAPVSNNHGGCLNQPCQGFVRWPCLVPLQSTQSLESSRPFPAPGTGSGGPRMRGEAPGMFLSSEGEIPRQRAREPAGARQEEVEVEWDWPLHPGHEQGPPRQTAPPTSGPRPCPCPTLPPRGRATASSRQAPTQLQGGTLESAQQSFLQLEQENHSLKRQNQDLREQLGALLGPGQQFLPLCSEHSSCTALAWVSGNTRSRTHAAAPPAVHSLGPDPGALPQSPESARTRLLEDRAPVQLLRQQELCPGKESFVRQSQSELQQIRLSFERKKMAITEVWDGVAEVHMALNNQATGLLNLKKDIRGVLEQMEDIQLEILGERAQCRTQARKQQQMMEAAGLEAAAGCSAGLHSGLRVRGGPHTLRGAGATPAEPSQRLEAQGLTGSLLTPGGGRLPAFLEQKPSGPSKEARWLVLPQGLRGLTGPCLQHCGTWPLPEAAEKGGGRASPEGWACSWIYSHDTLCM", "length": 481 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8M9PVG7-1", "protein_name": "5-hydroxytryptamine receptor 7", "gene_name": "htr7a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVLGDTNRTIIAKSHGETMKSLMAEERARETGASVETFNGIMISEVLVPRLFKIAHESGEVAVAAGSGSMDMKPSSSPILLEMMEVANGTRCAEQILSYGEVEKVLIGGVLTMLTLITICGNMLVVISVCFVKKLRQPSNYLIVSLALADLSVALAVMPFVSITDLIGGRWIFGKFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGWCMAKMVLSVWLLSASITLPPLFGWAQNVNDDRVCLISQDFGYTIYSTAVAFYIPMTVMLVMYYRIFRAAKLSAAKHTITGFPRVEQEEVEEDEVEEDGGDGAEEPTGVDCVTVAIKLQREVEECARLPRILRGVGRRCSDRRSISIFKREQKAAATLGIVVGAFTICWLPFFLLSTARPFICGTECSCIPLWVERTLLWLGYANSLINPFIYAFFNRDLRTTYRSLLSCRYRNINRRLSAAGMHEALRLVERPEVVVSG", "length": 479 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8M9QGZ8-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "pimr118", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLFTVLGVIALFLRERDTNNTEEEVQNDVPPVRNSDGQEIDDWCKEPSLLEPVSVHSEEPSLEEPVSAHSEEPSLEEPVSVHSEEPSLEEPVSVHSEEPSLVEPVSVHSEEPSLEEPVSVHSEEPSLEEPVSVHSEEPSLKEPVSVHSEEPSLVEPVSVHSEEPSLEEPVSVHSEEPSLEEPVSVHSEEPSLEEPVSVHSEEPSLEEPSLDLSFFSAESSWSEDLSSSFLTVESSWSDDLSSGFLTAESGCGDDEPLFVDSAEPEKLKEDKETQIIEINSHCYAIEAQLGEGGCGAVFSATRLEDGLQVAVKLSDFEEEKRFISVDGFEDPLPLEIALHFLANKGPKVKEIIELLDWKVEADRYFMVLEQPIPCMSLHEFLLDCEGIIPENKLRTIMYQTTVAAQTCCQRGVLHRDIKLENLLINPDTLEVKLIDFGCGDLLTEDSFQYFRGTREYFPPEFSSTGRYHGEPATVWSLGVVLFLLVFYRFPEQSDLPRMNNRRLRIKGLSRDCCDFFHGCLQLDPKDRLELQNLSSHKWIRTRTRRNDENCPNLTDGSSHSNHPITSN", "length": 567 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0WZU8-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "CHIR6B2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAPMVVNLILGWWLVAVSRAQKLPRPSLSLHPSQGASLGDNVTLRCHLPQPAAWVRLYRYQNPTYIEQKDNVQDMAEFSLTSIKQEDAVIYQCQYQGLAPAGTSQKSDPMELLVTDHRYPPPGISLSPKEHVEMGSNITIQCWNKDYGASFLLHKGGHSAPIQHQEPDYWGTATFTLFGVTPADSGTYRCSYRIGGCCLLFSPLGDNVTLEVIPRPAPPGVNGGPSRNLVAAVAGGCAAAIVIITVSFLLVALRRQMQRAERPGATPRSPEAVQFQVSPGDSEGLTYAQLQAVTPSTHPPTSSTTPEPPIIYAEVGTRGPR", "length": 321 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XEA0-1", "protein_name": "C-type lectin like 8, MHCY region", "gene_name": "YLEC8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQSVQIPILKHKVSTPAEGERLNHFSEHKAAPEPTAHQRRRIPTSSDPQLPEEDVQILLLESNTSTPAMGEGDQQETFSEHQAAPEPLGQSGGHQWGSWCHGMGRRRSCVQLIAVHAALGALILMLVVLVISTVCRRAPIPPFSAFGHACPNAWVGFQGKCYYFSKEENDWNSSREHCSAHGASLATIGSAEEMDFMMRFQGPANCWIGLHREEEDAQWTWSDGTAFTNWFELRGGGRCAYLNGDRISSSLCHLHKHWVCSRADHYVLWKQKVHPQ", "length": 276 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XED4-1", "protein_name": "C-type lectin like 18, MHCY region", "gene_name": "YLEC50", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQSVQIPILKHKVSTPAEGERLNHFSEHKAAPEPTAHQRRRIPTSSDPQLPEEDVQILLLESNTSTPAMGEGDQQETFSEHQAAPEPLGQSGGHQWGSWCHGMGRRRSCVQLIAVHAALGALILMLVVLVISTVCRRAPIPPFSAFGHACPNAWVGFQGKCYYLSKEENDWNSSREHCSAHGASLATIGSAEEMDFMMRFQGPANCWIGLHREEEDAQWTWSDGTAFTNWFELRGGGRCAYLNGDRISSSLCHLHKHWVCSRADHYVLWKQKAHPQ", "length": 276 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XEJ6-1", "protein_name": "Sulfotransferase", "gene_name": "LOC769841", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVCRAAAPNSHPSTMPVHYVTYKGIKFPPAYNSVHSLSFAHNEFLVRDDDVFNITYPKSGTVWMTEILSLIRSHGHPSWNQTVLNSDRMPWFSTRLGLEAALSYPSPRLLTCHLPRHIFPKSFSHSTAKVIYTLRDPRDVVVSYFYFCKMCNSYEDPVSFEQFLRDFLSGELPHGSWFEHVRGWMQMKDRENFFFITYEELKQDLQGSVRRLCHFLGQNLDDDAISSVVQNASFMAMRQNPMCSSILLPADIMDQTKGQFLRKGICGDWKNHFTVAQTETFNRIYLEKMRGLNVAFPWDRDQDPDLTEQ", "length": 309 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XGU1-1", "protein_name": "C-type lectin domain-containing protein", "gene_name": "YLEC62", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQSVQIPILKHKVSTPAEGERLNHFSEHKAAPEPTAHQRRRIPTGSDPQLPEEDVHISVLESNTSTPAMGEGDQQETFLEHKAVTEPLGQSGEKPQWGSRCHGTGRRRSRVQLIAVHAAVGALILMLVVLVISTVCRRASIPPFSAFGHACPNAWVGFQGKCYYFSKEENDWNSSREHCNAHGASLATIGSAEEMDFMMRFQGPANCWIGLHREEEDAQWTWSDGTAFTNWFELRGGGRCAYLNGDRISSSLCHLHKHWVCSRADHYVLWKQKVHPQ", "length": 277 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XGW1-1", "protein_name": "NHL repeat-containing protein 3", "gene_name": "NHLRC3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAPAVLWRLQRLSAAERLEARLSGAVRKEPGRGEARQSEKKPHSPHCPLRCSYACPGRTPMTSESGRKALSHLGRQQQCLNKMAELRARLEAFPAPECLFKTLNPFMGFLRLFFAPQPLGGEQALFRAAQCAEASPRIPAPQAWAGRSRGCHGNAARPASMGRKQAVGPRLVMAGALLTLLGLLWGSQMLKAFDYFSSWKGDGEQQMYKLDISWPKIPEYFSGQTFCVAVDSLHGLVYVGQRGDDIPKVLVFSVEGYFLYSWNDTVEMPHGIFVLNTATDSSVWITDVGSGKYGHTVKQYSPSGKLLQVLGTPGNAGSSLNPLQFDQPAEIFVEESGEMYIVDGDGGMNNRLLKLSQDYKEIWLSGENGTGIGQFKIPHSVTVDPFGRVWVADRDNRRIQVFDKVTGEWLGAWSSCFLEDGPYSVRFTGNYKYLIVAHLNINRLAILAAPPVGEIGDCAIVSTIQLADETKPHLVDVDVKSGAIYIAEIGAQQVQRFVPLS", "length": 502 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XPN1-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "CHIR2A13", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAPMAVALILGWWLVAASRAQQLPRPSLSLHPSQGVSLGDNVTLRCHLPRPAAWVWLYLEGRWSYAKYIDKKQDTTEFSFLSASHDQAGTYLCQYQVSESEDVSVTSDPVKLVLTDRSFPPPHISLHPEERVGTGTNVTICCWNKDYGATFLLHKDGRSDPIQRLVPDDVGAVSFTLFGVTPADSGTYRCSYHPKNYPFLSSPLGDSVTLEVTPTPAPPGAELVSRGNLVVAVVRGCAAALIFGLGVFFVIDARSLWIRRDESLGGEGI", "length": 269 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XPP6-1", "protein_name": "SUN domain-containing protein", "gene_name": "LOC776146", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEQQGHGERGNWQTKVWKTVALVLVTVAVASFGVYCVGGLVEGIKTTAGVTARLVRRDGEIVSLDEELAKVQRQLHVLQWRARDITERALHEALRRTELPGFTGEAVQKIIHQVLEKLEESPFQMTNYASKTSGAAIVRSKTSPSWIGSGRVFWQSLPLVAYMRPPEVILEPDNHPGNCWPFPGSQGHVFIKLPVAVFPTAVTINHGVPAAAYHADSISSAPKDFAVYGLQEEDDETGTLLGEFIFMPGQAPGQTFQLKNEHSAFIKYVRLQVLSNWGHPEYTCVYQFRLHGDPAPDGDARGKLSA", "length": 306 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XQE0-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "CHIR6A8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEPMAVNLILGWWLVAGSRAQQLPRPSLSLHPSRGVSLGNLVTLRCHLPRLAAWVWLYRGGGWSYKKGKKKEQDAAEFSFASTLREHAGRYRCQYRVYESAEVSVESDPVELVLTDVRYPPSSISLQPEQHVGTGTSVTIHCWNKDYGATFFLHKDGSSDPLQRQDSSGGGTATFTLFGVTPADSGTYRCSYRHWRYAFMSSPLGDSVMLEVTPTPAPPGAELVSRGNLVVAVVRGCAAVLIFALGVFFVIDARSLWIGRDESLGGKGI", "length": 269 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0XTD2-1", "protein_name": "Coiled-coil domain containing 97", "gene_name": "CCDC97", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKEDPKEAEGPTASKWIPIASNGNPTASKWIPIASNGDPTAPKWVPISSNGDPNWVPISSNRDPMASKWIPVSSDRDPTVTKENPPSSNETPAAEWDPKVPPEGRPVEEGDPKASPTEDPPAEPDPKASNCAPLSSHWAPEAAVWDPTSPHRDPTAEPQCSASPEQHRAAQRDPASPMEEDRYPATHGVRPATRADPAPYGDHPEAEEDPLPAAVEAMLAAVAASPVRVRSQQQGDPELTAAERRRDLRALFLRKPLVFLERFHGALQAEHLPCFAHLPPRYEVAFYCRQVRARRQQNPQTGLSRWPRRPGARTRLRNRRYAALRQLIAGGEYFSEEEMRAREPLLYEHYIGQYRDAETPPGTPPCPPHPGTPPGTTWAAALLRSVEEAAVQQRLQRQRLREGDSGEEDEDEDEAEEPHIPDAGELEVLREEFRSRMYQRFLDGEDRDFDYSQVDENPDMDNLDIESRDAEERYFDEEEPSAAPQLE", "length": 487 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0Y889-1", "protein_name": "Transmembrane protein 65", "gene_name": "TMEM65", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAWLGRAVLLLGRPGGPAAPSSSSRLCSLRGPPRCCCRRRLSSLRGGADGLLPARGAPPGRALGTHPKKEPMEALNTAQGARDFIYSLHSTERSCLLRELHRFESIAIAQDPIAARASCQQYGETWAHQEPSGACSSVHSQAYHQKEAVPSSNCPSTKYDRTHYLWPPLMAEAAGKPGRCPHCCAEGWSSEKLEVAPPSPGQLRHVFFHNALPFVGFGFLDNAIMIAAGTQIELSIGVVLGISTMAAAALGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQADMWQTRLSAHLGKAIGVTVGCILGMFPLLFFGDEEEKLEEKN", "length": 328 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0YA34-1", "protein_name": "SWIM-type domain-containing protein", "gene_name": "LOC100859602", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAERGQLPPYAKRLCCRPGYGSGCRLGQQAGDTGPGSGTFCAGPSSAAAAAAAAAAATAASLVLLPLGKTQSPESLLDIAARKVAEKWPFQRVEEQFERIPEPVQRRIVYWSFPRSEREICMYSSFDTGAEGFTAPGSAAGNTASGGAVDAVADENRLPFRRGMALLDGGCVDNVLQVGFHLSGTVTEPAMQSEPETVFNVAISFDRCKITSVTCSCGNKDIFYCAHVVALSLYRIRKPDQVKLHLPISETLFQMNRDQLQKFVQYLITVHHTEVLPTAQKLADEILSQNSEISQVHGAPDPTAGASIDDENCWHLDEEQVQEQVKLFLSQGGYHGSGKQLNLLFAKVREMLKMRDSNGARMLTLITDQFMADPRLLLWRQQGTAMTDKYRQLWDELGALWMCIVLNPHCKLEQKTSWLKQLKKWNCVDVCPWEDGNHGNELPNLTNALPQGANANQDSSNRPHRTVFTRAIEACDLHWQDSHLLHIISSDLYTNYCYHDDTESSLFDSHGWPLWHEHVPTACARVDALRSHGYSREALRLAIAIVNTLRRQQQKQLEMFQARKKELLYRGITSITNLEGWVGHPLDPIGTLFSSLMEACRVDDDNFHGFSDFMENTSQHKSLEYQHLPAHKFLEEGESYLMLAVEVALIGLGQQRIMPDGLYAQEKVCRNEEQLISKLQEIELDDTLVKIFRKQAVFLLEAGPYSGLGEVIHRESVPMHTFAKYLFTSLLPHDAELAYKITLRAMRLLVLESTAPSGDMSHPHHIASIVPNRYPRWFNLSHIESQQCELASTMLSAAKGDVQRLETVLQSIQKNIHSSSHIFKLAQDAFKIATLTDSLPDITLLKVSLELGLQVMRMTLSTLNWRRREMVRWLVTCATELGVHALDSIMQNWFTLFTPTEATSIVATTVMSNSTIVRLHLDCLQQEKLAGSARTLALQCAMKDPQNCALSALTLCEKDHIAFETAYQIVLDAATTGMSYSQLFTIARYMEHRGYPMRAYKLATLAMTHLNLSYNQDTHPAINDVLWACALSHSLGKNELAAIIPLVVKSVKCATVLSDILRRCTLTTPGMVGLQGRRNSVKLMSLDKAPLRQLLDATIGAYINTTHSRLTHISPRHYGEFIEFLSKARETFLMSHDGQIQFTQFINNLKQIYKGKKKLMMLVRERFG", "length": 1168 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0YDY5-1", "protein_name": "SKA complex subunit 1", "gene_name": "SKA1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEAEGLEALSRHLAAKIGLIKRLLQLRGLGRREMLAEVGMEVAVLHGLLGRMEEEVNQRRQLAAALQEMRKRAEKEKWEAERLQLVKKAAKEAPLVNDAPLISDEEFESVPGYMRGRLTLAQTNAALRALHAAAASKYRLLRHPPKSLPSSSRALCHRFREEETKETQGLTFVVEADLKEFTQLKVDRTFHRIVGVLRHCRRLREVRGARLVRYVLP", "length": 217 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0Z0M2-1", "protein_name": "Tumor necrosis factor ligand superfamily member 10", "gene_name": "TNFSF10", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLPAGGPSPAHTCGAVLVAAVLLQSVCVAVTYIYFTNELKQFANADLVHSCERGHPLSPPPPPDVPQTAVTRPTKAEGGAAPVGASCSIGQSRRAQSDLRQRAANAASPQHGPPCAARSRARCSCPRCTAGPRVCRRTQQKLWDTYSRSGTACLTGEELGDLIQNLDVVESKDRVADPCWQVKWHLGKLIKKMMSRILQENMSAINGDRTQALPRRDEPPQGPTLRIAAHLTGSSKRSSASPHIDYLSYRGIGHKIHSWESSRRGHSFLYNVELWNGELVVPQTGFYYIYSQTYFRFRENEDEDSGLLERIKNPKQLVQYIYKLTNYPDPILLMKSARTSCWSKKAEYGLYSIYQGGVFQLKREDRIFVSVSNSDIVDMDKEASFFGAFMIS", "length": 392 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0ZCD9-1", "protein_name": "Mab-21-like HhH/H2TH-like domain-containing protein", "gene_name": "LOC124418390", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALVLVLALLVRALIVSGSDHAVMLERVQQHEKEQRNGEQSWVDMSALLFTLLHYWKIWFCTGLFVFLFWNMWRSLKRKQHEEGGQQEQQEREEQVEEVEREEQQEQVEEEEQLERVEELEQEDQVEHVEQEEQEEREDQGEQVQQEEQVEEVEQEDEEEEYFHHSALTRYIARRAWEKMQGKATKCVLVEELMSDLLQTYTFVCSNSFYPVLQPAIGVGSAFEGWSPCEEDIVYRLLVPIKAPHGHVFHPELGEEGEVLARNSRIRVELVCMCTREQQLGDVLCFLHHSEEELSQNQQPSLLQTLCTGSYLDVQKTAAWFNKQVPRTWRLTHRAHRYGLKVLPSSRSCKLQVTDTSSGEKVHVELLFGVQQGNLDIFLSSQNAEAVFTPSTTWPQSCAVAERKYFEYVARTAGPNSCHLVCLRLFAHILVGMGFSTYAIKTLLLHLLAIIPLEDWRRRHFLSRLENLLQYLQYCLNDKVLNHFLLGNATMPDEVVLPQAFQTASPLNLFQHLEQDPDAHSRVLRDFKELKDRLFRLLLFGR", "length": 542 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0ZD85-1", "protein_name": "Mab-21-like HhH/H2TH-like domain-containing protein", "gene_name": "LOC124418382", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALVLVLALLVRALIVSGSDHAVMLERVQQHEKEQRNGEQSWVDMPALLFTLLHYWKIWLCTGLFVFLFWNMWRSLKRKQHEEGGQQEQQEREEQVEEVEPEEQQEQVEQEEQLERVEELERVDQVEHVEQEEREDQGEQVQQEEQVEEVEREDEEDEYFYHSALTRYIARRAWEKMQGRATKCVLVEELMRDLLQTFTFVCPNSFYPVLQPAIGVGSAFEGWSPCEEDIVYHLLVPIKAPHGHVFHPELGEEGDMLARNSRIRVELVCMCTREQQLGDVLCFLHHSQEELSQNQQPSLLQTLCTGSYLDVQKTAAWFNKQVPRIWRLTHRAHRYGLKVLPSSRSCKLQVTDTSSGEKVHVELLFGVQQGNLDIFLSSQNAEAIFTPSTTWPQSCAVAERKYFEYVARTAGPNSCHLVCLRLFAHILVGMGFSTYAIKTLLLHLLAIIPLEDWRRRHFLSRLENLLQYLQYCLNDKLLNHFLLGNATMPDEVVLPQAFQTASPLNLFQHLEQDPDAHSRALRDFKELKDRLFRLLLFGR", "length": 539 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0ZE07-1", "protein_name": "LIM domain only 1", "gene_name": "LIMO1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVLDKEDGVPMLSVQPKGKQKGCAGCNRKIKDRYLLKALDKYWHEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLFGTTGNCAACSKLIPAFEMVMRARDNVYHLDCFACQLCNQRDSNPMGWYGSHPVTAAWEAEARTTSLGQPGVRAAELP", "length": 158 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0ZGC1-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "LOC124416945", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVAGSPALLLLLSLGLCFTGAQGQGNTMAVSFLNRSMKHPKEGQRLGLECHTYKTSWGVSWIRLDKDGNLHFIVYISKFSSTTFPGNKGASSQFEVSKQGSSYRLTVKNFRAQDQGIYFCIANINQVLHFSSGQRAFFPVTTTTAAPTTLRAVTLTATTQSSQVTMKDISQHSPDPGRSKENMPNFCCKLVMWVNLACACLLLLTAITITTTHCQRPSSP", "length": 220 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V0ZPB4-1", "protein_name": "trypsin", "gene_name": "LOC107049069", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKFLVLVAFVGVAVAFPIRDEDDDKIVGGYSCARSAAPYQVSLNSGCHFCGGSLISSQWVLSAAHCYKSSIQVKLGEYNLAAQDGSEQTISSSKVIRHSGYNANTLNNDTMLIKLSKAATLNSYVNTVPLPTSCVTAGTTCLISGWGNTLSSGSLYPDVLQCLNAPVLSSSQCSSAYPGRITSNMICIGYLNGGKDSCQGDSGGPVVCNGQLQGIVSWGFGCAQKGYPGVYTKVCNYVSWIKTTMSSN", "length": 248 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V1A1Z3-1", "protein_name": "Bridging integrator 2", "gene_name": "BIN2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPSLYHPNAIPVPFPSHPCTTLMSSLTHHIIPVPSSCLPNVIPIPYHPHVISTLSLLHPHFIPMAFLNLPHAIPVPPLIHSCAVPMSYHPFPISFSFPSPSHPSIAPMQSPSYPYPTPVPPPFHLLPIPIPTPVPPPCHSCSIPIQPRCRLHAILVPFPPHCHPHPVPAPSPPHPSAIPMPSHFHPHPIPVPPHTISIPSPPQCHLHAIPVPSPTHPHPIPSHPRFPHPLWAQGHPHPRGSNLSPPIPPPPPNTFALQNEGNKLYKDLKAFVGAVKVMHESSRKVAETLQEIYSTEWDGHVELKAIADSNDLLWDDYEAKLGDQALRLMENYLAQFGDIKERIAKRGRKLVDYDSARHHLEALQNAKKKDEAKIAKAEEEFNRAQAVFEELNRELREELPVLYGSRIACYVTIFQNISNLRDIFYKEMSKLNRDLYEVMGKLDKQHSSKVFIIKGVPSKRRSLLISAPVSPPAAYPCPGKAPNWDPSSGAEQTPTSPRVGSDATEDVPNGLAAPGPAEPGAPMPGPPPASPTSVRSASESESECSEESREIDLSPKEMEVSVGSGCPEYPKTEGAAKGEVEGIAASMASMIVSEAIAAATGAAPGDSDGVGGGDSTDSEISPAEGAWGGPSPGGSEERVEGTDVSPEVGSDAGPCEHGTPEPPQQDVSCDPPQDPSESLTPL", "length": 682 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V1A7J1-1", "protein_name": "Mitochondrial transcription termination factor 4", "gene_name": "MTERF4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGRLLGLLRARAPRAVLPAPGPASRHRCGTAGPEEGEAAELLAMGFSQAQARRLRLLRPGLEPQRRAEAAAQLLLLGLSAEAALGLLERSPGLLRMETARLKERAEYLRRLGLEGERGGPLPRGVHAAPAEDGGGGAAAAGAVSVHGRAADRAAAELPRGAAGGAGPRAAPLPGAGRRAGRSGGVAGAARPALSSARLHAQYAYFRMGVRQKEMVKARLFRTPFAELRNRHVFLERRGLYRTPHKGQSQSGNPALRDVLRPTEGDFVAGVARASPDEYEVFKRLLAREEEEMEEEEEEDEEEEEEEEGSAALHAEGGDRDWHSSEPSPIAPCPPAPQ", "length": 338 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V1AKD9-1", "protein_name": "Borealin", "gene_name": "LOC121107214", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAPARRKAAAGARGRKLSAFLKDFDREVRSRVEQLRTNGERLVKEMENLYDVELLRLPAALREMNWLEFFAKGGSQKVVEEAVTADLGITEINKLTAELIQTPLKIVTKEKSKQGIEATEEAAEVPLLPPAKKAKHDSQLLLEQAAASTNPRNGKVRTSTKKAPVSRSRRAPSARVKRVSKRSSKSSFITPATGRNLDLCARGGASIVTPRFDSRVFKTPGLRTPAVNERVYTISANGSPLADGNDVFITVPVGGGESIRLTASDLTKKNLLHLNPEARGIMKKLSVRLAQACSSAKTHR", "length": 300 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8V1AMC7-1", "protein_name": "ODF3A protein", "gene_name": "LOC121107218", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPASMDGAWVGTWRPHRPRGLISAQFPSPGPQYSIPGTTGYVGHSPTKARAPAYTFRGTKPPAAGSCGPGPCYFVEPAITRNGKYVAPGAQLRGRPVTKTTVTPGPSDYRTEAANRHVFKCPPVQSMAFRREPLRTDHPPGPGTYTLPRLMGPNTVYTSASPCYSVRGRSQRGRFDEDLAKTPGPAALPKVPVDAYKTRAPAYTMAARPKAGEGKAAKPGPADYSVGRVTLIKPQAPASTFGIRHSLYTTPLIVE", "length": 255 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8W4F7J1-1", "protein_name": "40S ribosomal protein S26", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQPIHCTNCARCMPKDKAIEKFIIRNIVEAAAVGVISEVSVFAAYVLPKLYAKRHYCESCAIHSKVIRNRSREAQKVRTPPPRFRPTGAALRPPPKCM", "length": 98 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4F8K9-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258234", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRNHTVTTFILLGLTDEPQLKTLVFIFLFLTYMLSVTGNIISLTSTDSHLKTAMYFFLQNFSFLEIAFTSACIPKYLYNIATGDKTITYNSCATQLFFTDLFAVTEFFLLATMSYDRYVAICKPLHYVTIVNHTVCRRLIFGSWLAGLLIIIPPLSLGLKLEFCDSNVIDHFVCDAAPLLKISCSETWLIEQMVIVCAVLTFIMTLMCVVLSYVHILKTILQFPSAQQRKKAFSTCSSHMIMVSISYGSCIFIYVKPSPKDSLAVNKGVTILTTSIAPMLNPFIYTLRNKQVKQAFNDAIKRIALFSKN", "length": 309 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4F9E2-1", "protein_name": "UPAR/Ly6 domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "RLEFSSLSPAEVPLVAAAGGRGAFDMRCHECDTKNTFACDHIVTCPRGIRRCLTLSIRLSSREIYVYKGCTRNCTFIYADEQPPPGERKPPRSNSLYFVQCCNAITCNRGGPINLEKDITPPLILEEELGGTVRLGEATLFLSVASVLVSHALT", "length": 154 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FBC5-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLTHSFSFFSSSSSSSTYSSSYPLLPLLLQPQNQFRIWALKDYGQRNSTSLHDFILLGVVATFYLITLVGNTAIILASLLDSHLHTPMYFFLRNLSFLDLCFTTSIVPQMLLYVYMWLGSIECLLLAVMSYDRFTAICKPLHYLVIMNPHLCLKMIIMVWSISLANSVVLCTLTLNLPRCGNNLLDHFLCELPAMLKIACIDTTAVELSVFALGIAIVLTPLILILISYGYIAKAVLRMKSTAGQRKAINTCGSHLTVVSIFYGAIIYLYLQPGNSASKDQGKFLTLFYTIITPSLNPLIYTLRNKDMKEALKKLMRVDHKSTKSKRTWKS", "length": 331 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FBS2-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258626", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRNHTAITTFILLGLTEDPQLQLLLFLFLFLTYILSVAGNLTIITLTLLDPHLKTPMYFFLQNFSLLEISFTTACIPRFLYSISTGDRTITYNTCFTQLFLTDLFVITEFFLLATMAYDRYVAICKPLHYMTIMSNKLCKTMVVCCWLAALLIILPPFSLCFHLEFCDSNLIDHFACDASPLLKISCSDTWLIEQMVIACAVLTFIITLVGVVLSYIYIIRTILKFPSAQQRKKAFSTCSSHMIVVSITYGSCIFIYINPSAKEEVNLNKSVSLLISPISPVLNPFIYTLRNKQVKQALHDSLKKTAFLLRK", "length": 312 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FCJ2-1", "protein_name": "Histone H2A", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSRKRNLPQCNPPKKQALSRSSRAELQFPVSRVDRYLREGRYAQRLSSHTPVFLAGVLEYLTANILELAAGEAHSSRKMRIAPEHVQRARSHNETLSSLFQASSVSRGAEEEAEEPLPEAGR", "length": 122 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FD42-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTALNHTGVSHTVFYLLGIPGLEDQHLWISIPFFISYVTALLGNSLLIFIILTRRSLHEPMFLFLCMLAGADLVLSTCTVPQALAIFWFRAGEISLNCCITQLFFIHSIFVFESGLLLVMAFDRYVAICYPLRYTTILTHPLIGKIGVTIVLRSYCAIFPIIFLLKRLTFCRSNVLPHTGCEHIGLAKYACNDIRVNIWYGLFVIVSTLLLDILLIFVSYMLILHAVFHMPSQDARHKALNTCGSHVCIIILFYGPGIFTALTQRFGRHIPAHIHILLANVCILVPPMLNPIIYGIKTKAIQEQVALILFPKYR", "length": 314 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FH98-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "VCHYGNYYSGLSCSCGYGCGYSRCGCNCDYDKCGYRCGYGGYVYGCCHLSCCGRYRPYGFY", "length": 61 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FHY5-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "DTGSCGAIVLTQTPLSLSVSPGEPASISCRSSQSLEEYGKNWLSWYQQKPGQSPRLLIYQATNRASWVPERFSGSGSGTDFTLKISRVEAEDAGVYYCQQYKEFPPTVIQPLTQTPLLGAQLHTWLCVVWGAEGQKL", "length": 137 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FIZ4-1", "protein_name": "Envelope glycoprotein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRPTLSRRHLPTRGGEPKRLRIPLSFASITWFLTLTITPQASSKRLVDSLTSPKPLSLTWLLTDSSTGITINSTQREAPLGTWWPELHVCLRLVIPGLNTMSTPPDILRAYGFYVCPGPPNNEEYCGNPRDFFCKKWSCVTSNDGYWKWPTSRQDRVTFSFVNSYTSYNQFNYGHGRWKDWQRQTQNRQISCSPSDLDYLKISFTEKGKRENIQKWINGMSWGVVYYRGSWGGEGSILTIRLRIETQMEPPVAVGPNKVLTEQGPPIQGQRPSPNPSDFNTTSG", "length": 284 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FJ61-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSTKNKHLMKGSKKGPKKKVADPFSKKDWYDGKAPAMLTKKRNIRKTLVTGTQRTKITSDGLKGHVFSSEPCQSAE", "length": 77 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FJT7-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKNPEVRKIHSAVFLITYLSTILGNLLIVVTMVTSQSLRSPMYFFLTSLSLMYVTYSSVIAPKMIVDSFSETTAISLEGCMAQLFAEHFFGGVGIILIIVMAYDHYVVCCLLLGGAWVGGSIHATIQLLFICQTPFCGPNVIDCFMCDLFTLLKLACMDTHLLGILVILNSGVMCMAIILILITSYVVILCSLKSYSFEGQHKALSTCGSHLIVVVLFFVPCIFLYVMPVATYPIDKAMAVSFTIVAPMLNPLTCTLRNAEVNNAMRKLWMKQNTLCYH", "length": 279 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FKQ6-1", "protein_name": "Large ribosomal subunit protein uL5", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVQDQDEKKNPMWELGIHKLCLNICEGESGNRLTRAAEVLKQLTGQSPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEIFERHLRVREYKVQEHISLGTKYDPSIGIYSLDFYVVLGRPGFSFADKKHRTGCIGAKHGISKEDAMSWFQQKYDEIILPGK", "length": 163 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FKY3-1", "protein_name": "Large ribosomal subunit protein eL27", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGKFVKPGKVVLVLAGRYSGRKAVIVKNTDDGTSDQPYSHALVAGIDRYPRKVTAAMGKKKIAKSSKIQSFVKYSVDIPLHKTVVNKDVFRDPALKRKARREAKVKFEERYKTGKNKCFFQKLRF", "length": 125 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FLM5-1", "protein_name": "Small ribosomal subunit protein uS14", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGHQQLYWSHLRKFGQGSRSCCVCSNWHGLIRKYSLDMCHQRFCQHMKDPGFIRLD", "length": 56 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FNC8-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGQRNQTSSLADFILEGLFDDSPAHAFLFSLTMVVFLIAVSGNTLTILLICADPRLHTPMYVLLTNYLSGTKSISFVGCATQYFLFLSLGCAECILLTFMSYDRYVAICHPLRYAVLMNRKVGQMMAVMSWLGASVNSLIHTVILMHFPFCGHRNIHHFYCEFPAVVQLVCGDITVYEIAVYIGDIVLLLLPIALISASYVFILHSVIRMHSAGGKRNAFATCSSHLTVVSLWFGACIFSYMRPRSQRTPLQDKVGSVFYTIITPTLNPLIYTLRNKDIAKALKRVLGREMITQNPKVRLP", "length": 301 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FP10-1", "protein_name": "Ribosomal protein L19", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSVLRLQKRLASSVLRCGKKKVWLDPDETREIANAKSRQQIWKLIKDGLSIQKPGTVHSRARCQKNTLRKGTASAGMPKKSVPERDGNVFKNKRILMEHTHQLKADKARKKLLADQPEARRSKTKEARKRRQERLQAKKEERNRTEVETKFCRLI", "length": 155 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FP36-1", "protein_name": "Small ribosomal subunit protein eS24", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQDTASIRTRKFRTNQLLPGKQRVIRVLHPGKATVPKTEIWGKLAKMNKRTPDVIFVFGFRTHFGGGKTTGFGMSHDSLDDYTKTNEPKHKRARHGLYEKSKTSRKQRKERKNRMKKVGGTAKANAGAGQKGGV", "length": 134 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8W4FQE1-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTALNHTGVSHTVFYLLGIPGLEDQHLWISIPFFISYVTALLGNSLLIFLILTRRSLHEPMFLFLCMLAGADLVLSTCTVPQALAIFWFRAGEISLDRCITQLFFIHSIFIFESGLLLVMAFDRYVAICYPLRYTTILTHTLIGKIGVTIVLRSYCAIFPIIFLLKRLTFCRSNVLPHTGCEHIGLAKYACNDIRVNIWYGLFVIVSTLFLDVLLIFVSYMLILHAVFHMPSQDARHKALNTCGSHVSVIILFYGPGFFTTLTQRFGRHIPAHIHILLANVCVLVPPMLNPIIYGIKTKAIREQVAHLLFPKQK", "length": 314 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7F7T0-1", "protein_name": "Protein transport protein Sec61 subunit gamma", "gene_name": "LOC100757015", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDYVMQFVEPSGQFVKDSIWLVKRCTKLDRKEFQKVAMSTAMVFAIMGFTGFVKLIHIPVNNIIVGG", "length": 67 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A9J7GY23-1", "protein_name": "Tetratricopeptide repeat protein 16 isoform X2", "gene_name": "Ttc16", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTDSSTEESVNVQTQKIPKLQVPETRETTLQRIFGTSQVFYSVSGVVKPRLTESTVPFRVREYYHQGHHCLEQEDWEMAVLYFSRALHLNPDQVEFYIFRAEAFIQLCDFSSALQNLRRAYSYEPENSKYLERLAFVLYLQGQCLYELCDFQEALYVFLQASDLQPQNPSFSYRCMACLLALNRHQDCLSLVTREVKQGRATADVYILRARIYNFFQKPKLCYQDLRSALLFNPKHPQAKGLLQVMVDQAKKSLQDASILAVQGKLHRALKRISCAIENNPLDPNLFLFRGTLHRRLQQFDPAVEDFLKAMDMVTDSQDNLVQKTQRQLLLTYNDFAVHCYTQGAYQEGVLLLNKAIRDEQNEKGLYINRGDCFFQLGNLAFAEADYKQALELCPKDEGANLRMGVLQEKMGLCEQTRRQFQKAEDHFSAAIKYNPVNAQYYLHRAKNRQLLQNIVGACQDIATVLLLNPKYPKMAPLMAKLFPGMSVEEVLNSHVAQLAKLQLRRMIESGPKASHPQSIVAKRLIERQKAQALMESWNWEQLFTRNPEEEVAPSESLQGKTLREKIEFKREVVEEKKVKILRKVTSLSDSYVDQTSSGSEFSILSPSTLETEVSTMEYKSTSNTAASSAERLLPQYLVTTKYKESLGLSMAPNVTQVSEDLHKSLTENIPDDGPRHHSSKAEATQRPKPRKTEPSQSLGKQRPSQRPSITEATKGPKPRKNRPALSPRQRLRRAKAVQAQNWKPRTNSNSQKTSSLLSNIAVIISSSNEAQDQSPVPSKADDISSYNDSTATSSTNTDSLRLSIHLSKPKYSKDQSPSHNKEEVSPTSNNYAAP", "length": 835 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A9J7GZF8-1", "protein_name": "Protein EURL homolog isoform X2", "gene_name": "C4H21orf91", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MIIKRKATVIHHKGTMNEEEQFVNIDLNDDNICSVCKLGTDKETLSFCHICFELNLEGVPKSNLLHTRSLRGHKDCFEKYHLIANQDCSRSKLSKSTYEGVKTLLTKKINWIVQYAQNKDMDLDSECSKNTRHHLFNFRHKPDKKLLPQFDSQVPKYSVKGIAGSTGGLSSYTQRILEQRENTDFGLAILQDSDALWPHKHNQAQKKEETSSGPENVQTQNPRYSREELNSMTLDEVEQLNTKLQQQIQEVFEELTHQVQEKDSLASELHVRHVAIEQLLKNYSKLPCLQVGRAGPRSHLPINN", "length": 304 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A9J7JMJ4-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100771730", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDFVNISLVTEFFLVGLTDQPELQMPLFFLFLAVYLITALGNLCLIILTVLNSNLHTPMYFFLFNLSFIDICYCSVFTPQMLMNFILRENIISYMECMAQVFFFCFFVVSECYVLTSMAYDRYMAIYNPLLYNVVMSPNLCLNLMFGSYFIGFSNAVAHTVCMLRLTFCDTNIINHYFCDIPPLLQLSCTSTYVNKLVIFVFASINIIVPTSTILVSYGFILSSIFHISSSEGRSKAFSTCSSHIIAVSLFFGSGALVYFKPSSAVYMNEGKISSVFYTNVVPMLNPLIYSLRNKDIKVALMKSLNSRNL", "length": 310 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0AA74KSW7-1", "protein_name": "Predicted gene 3002", "gene_name": "Gm3002", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLNSSKLGVWAAGVPPSSPTLLFRRWVMKVESLISQPMTSGKNELQDHLIFISEKALHKRLFQKENGDEGVTRPTEKEEGILSHEKGRRKWLWRRHRSARNTSTQNSKMTKKRSKINELEELKLDMRKISNDMEEMCGILNLYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLHENVRILLNENRRLLVEQAGHKCPVGKKRGSLRRPARTSVSQVPRNTSPAESRTWHRPGHDLPQREVLEEEH", "length": 280 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0AAA9RU54-1", "protein_name": "Small integral membrane protein 17", "gene_name": "SMIM17", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MQSLRPEQVRGLLEPERAKTLLPRENKAWEKRAAFAKDWVAVEVGASGCGSDEKDLPSPKTLVPQEWSSVEEDDESEDSQPHWAAALPTSPSCPSQDTGTGSGADLCLQCSSPRTPPWLPWAFSHTIESALPTPPRAWLWSLL", "length": 143 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0AAA9RY85-1", "protein_name": "Core Histone H2A/H2B/H3 domain-containing protein", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MNMPEPAKSAPAPKKGSKKAVTKAQKKDSKKRKRSRKESYSVYVYKVLKQVHPDTGISSKALGIMNSFLNDIFERITGKTSRLVHYNKRSTITSREIQTTVRLLLPGELAKHAESEGTKAVTSIPALSKYNMPSRC", "length": 136 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0ABK0KVZ2-1", "protein_name": "Eukaryotic translation initiation factor 1", "gene_name": "Eif1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "EFGFRSVASAGWGAACPLGLRHVISCGGRAGLEQKARALSSSSTGLFPEGQQRAPPDFSDDICTDKKKNQERGINKWPTTTRNKNYFFVDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLIEIGLAKDDQLKVHGF", "length": 192 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0ABK0L002-1", "protein_name": "Oocyte specific homeobox 2 like 1", "gene_name": "Obox2l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "ILQSVQNTDMIEGPSFLPKFQMSSYTPMDTSSQLPQEPSWNLAFQMGQSPLVTSRTPMQSSPSVPEQNLNWQESQGSSRESSIQMQPGPVMDPGFPTLRSPSGHPSHQRPSRPSSRSGFHVPIEPMALSDKHGGKQTGPVAPRKCRKERTQYSAKQKSVLQEHFAECQYPDKKLCLELATLFGVTENEIKVWFKNNRAKCKQKNVPEALPETNGGPEAVSWSTDFPGSIAVVGCDQGEPMATAILDVDSTPKLNCSQESSLDGNWTYDGAMCCLPEDVLDGNDPVTAGDSGESAPVEAQSDLAAAGAPVAMAVDTQNPEECEDLPLLDEGVWQWMLEDFHQLEDWFTKNYIESPSSASHPLD", "length": 362 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0ABK0LHI6-1", "protein_name": "CD27 antigen", "gene_name": "Cd27", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAWPPLYWLCMLGTLVGLLATPAPNNCPDRHYWIGAGLCCQMCGPGTFLVKHCDQDRAAAQCDPCIPGTSFSPDYHTRPHCESCRHCNSGFLIRNCTVTANAECTCSKGWQCRDQECTECDPPLNPALTSQPSEAPSPQLPPPTHLPYATEKPSWPPQRQLPDSTVYSRLPSQRPLCSSDCIRIFVTFSSMLLVFVLGGILFFHQRRNHGPNEDSQAVPEELCPYSCPREEEGSVIPIQEDYRKPEPASYP", "length": 251 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0ABK0LYA6-1", "protein_name": "Prostate and testis expressed 2", "gene_name": "Pate2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSCLTSELQGSACLCLPSTGSYKHILQHLDLGTMCYKCKKYHLGLCYGLMRSCTLKHRQSCAAENFYILTNRGQSMYHYSRLSCMTNCEDINFLSFERRTELICCKHSSYCNLPMGL", "length": 118 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0ABK0M6C3-1", "protein_name": "Prohibitin", "gene_name": "AABR07037878.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYNKNIKNSISISVCVGGVGGVRARAHAHAHTSPHACTRVIHAFVMLEVGPRDFVHIKKAFRGIDVKKPVIFDCRSQPRNVPVVTGSKDLQNVNITLRILFRPVTSQLPRIYTSIGLDYAERVLPSITSEILKSVVARFNAEELITQRELVSKQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAETARFVVEKAEHQKAAAIISAEGDAKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSSSQNITYLPVGPSSVGPSVRQSMFLRLPQ", "length": 286 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0AC58FXL6-1", "protein_name": "Cytochrome P450 2X10.2 isoform X2", "gene_name": "cyp2x10.2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSDLRGIYSYMLSTVNSLVRDSSLTNFKKEFCVHAYLLSVCIQYQSSVWSSSRSVTMLTALVLLCLGAFLLYLQLRIRRPKNFPPGPAPVPIFGNLLQLNRISPLKDFDKFAQHYGSIYGIYIGSQPAVVLTGQKMIKEALITQAAEFSGRSNNMMFSHVTGGKGVIMADYGESWREHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLLEESAGKSIDPQHLYHQAASNIIASVIFGSRFNYKDAYFQTLITSVEDLTKITIGPWAMLYEIAPVLRIFPLPFQKAFQYFEQITKHVLKVVEEHKTSRVAGEPRDLIDCYLEEMENKSDHRTSFDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQEQCQREIDEVLGARDHVTYEDRNAMHFVQAVIHEGQRVADIAPLSMFHSAKTDTQLRGYSIPKGTIIIPYLSSSLREEGQWKFPHEFNPQNFLNEKGEFVKNDAFMPFSAGPRVCLGENLARMELFLILVTVLRRFRLVWPKDAGEPDFTYIYGGTQSVKPYRVIVEPRMHGEACKFVD", "length": 552 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0AC58J797-1", "protein_name": "Uncharacterized protein isoform X1", "gene_name": "si:dkey-233e3.2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MANAKQLLKNSLDELVEAELKEFQWYLINDHRDISKAEMEKADRLKTVDKMVSCFGPKGAVKTTVDILRKINQNELAEELENKHKQGNCMSARAEGAVLETCKSPPFDYTNTSRELKKKLKEDYEKILVGNSQTGHKKYLEDIYTDLYVVENETGGRERQHEVIQMESKHNQQDRPLKCNDMFKVQPDTGRKHRRILTLGIAGVGKTVSVNKFILDWAEGKDNQEIVFIFPLPFRRLNLIKEEKYSLIGLLNKYFFSISGGLSSLPEKQGKVMFIFDGLDEYRFKLNFKKDDGFTDVNKEMTVSEIITNLLKRHLVPSSLMWITSRPAASSLIPRDLIDQVTEVRGFIDEQKEHYFIKNSSPEVARNIIGHIKKSRSLYIMCHIPVFCLISLTVLQPLLGQESNEKTPTTLTGMYINFLLSQKQQMKEKYRNDTESEANACSFDEIVLKLGKLAFKQLQKGQLIFYKTDLEKCGLDVRQGSVFSGLCTRMFQEENHYSGEQVYSFVHLSVQEFIAALYVFFTYKNKKANLFLDSWKKELKWKLSEKPLFKLHTAAVKKTLQSKNGHLDLFLRFLMGLSLESNQSDMKELLPWLKLKTGMIKDTTDYIKKKIEEENSAERTINLFHCLNELNDDFVEELQKSLCSGNLTAQDLSSAQWSGLVFVLLMSEETQEKFELQKYRRSDEALMRLIPVVKNTTRALLQCCNLTAQSCESLSSALQSSNCVLRELDLSNNDLQDSGVNLLSNGLKSPKCKLEILRLSGCMVTEEGCGFLSSALTSNPSHLRELDLSYNHPGDSGLKLLSQKLEDPNYTLNKLNLDHGGEKWFTAGLHKYACFLTLAPNTAHIELRLSEENRRVTRVGERQQYPDHPDRFDHHAHVLCRESVCGRCYWEIEMNAGDRVDIAVSYKSIKRKGRGYECVLGQNAQSWALICYVNRVAFRHNMIETRLPVKLMSRRIGVFVDHSAGTLIFHNIYRDSMSLIHSVQTTFTEPLYPGFWVEYGSSVKLC", "length": 1006 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0AC58JHM1-1", "protein_name": "Phoenix isoform X1", "gene_name": "pho", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDLRSKGDTSVGEVMEADPRAELIFETPPPDVVSSINACFEEIDSALKIRRDPSVHSPPSDSDSESLFITQSVTKVVHTKRRLRSSKKPDSISDDSGYVRERRLSENQQTECEEESRSLRSSRRKRSKWEMYASARKATFPFLMKSLKTQHLPIRKHQILENSEVGGFFKCIKKIKTGSVKMGKVISSHLFQSPISDSSEEEDQNSEHDVISVDKALFVPGYKRGINFKWLPDFIRERRTLENYLSNGVDKEKKTEQIIEYRQRNQHPQRTSAKALSKSSQVSKKPKKQDTHEVLASCSDHEDLEIAECAENSHEGHKVVIEETQRQTVEEASAHLEHEDDLNCKVVEYRKRKRHPKRTSAKALSKSSQVSKKPKKQDTHEVLASCSDHEDIESVECAENSHEDHNVVIEETQRQTVEEASAHLEHEDDLNCKNQPDVDQPNESNFIGPPQEGDISTQSDTQQTDSDIGSVDLFSPLNSPKRDDQIPNTTSITANVEENDQDSDVTQIESEGQHVSTFTQETQKCFANEEYDSDETHIDTESLSRFKPRTPNKQFTSTKHPEIPQFRVQSPKPPSRQAETVNVQLSPKHLPLSNVPLSEVPISPCESAIVGRQKTMVETETDSPMFKITGPSFLKRKRKRTKDKNAAADFKQHDTNGDVGQMVSCPGDDITGLKAVPIENIEACGVEHEMAIGEQTEELGLKSKELLEESVLSTVNSVSTKSKREKMKKYKVKECEAVENQLVETSKKAKKKKKDKERIATSYPEENNLTNIQSNEGFDSAELRVKEVNQSSQSLNTDQPTCVQTSEEITGETELKKKTTRHETDDPLYESVGLDVTLASQFDVGLRIDEQQEGLVTEEAERDERLQGKAMKVAKGKKKIQDTSFQVDHDIGLDKQRSDSGAKPANLDLDGLESLTIKKKKKKKKKHKLKEKTDPKLDFDFDHNVQFFQTDRLQTTDSVLLDSTHTNKQKKKKLKCQNDTDQSSDLKQLHVVGSKLQTIDLPKTDKHMERTGVSSSDALLEHMDDRTLGMRENNTIQTDQIEHLQTSEEVTRCSSPRLSSDKKREKTSVHPNLDASSVFQFDGFKANEDQAITQNTTKEKQISSEQLENNLVGPPSQVENIANVNSSVLLDHTHMNTLREGQLKEQTYKELALAFGLKQLCIVVNKLKTTDLPKTNKNMEGTGVGSSDELLKHTDDRTLETRENNTIQTNQIEHLQTSEKVERHSSPRVTRLSFAKKWMKTSVDSNLDASSGSQFDGLNSMAKEDWTFSQNMDLPLKRTKNKQKDKERTGVSSDALLKRMDDRPPEMRKKNTIQTNQIEYLQTSEKVTRRSSPRLTRLSLAKKMEKTSVDPNLDASSGSQFDGLKEASKEDRTAPRNSIEEKQSDAISSEGLENNPAHLVSTNKSDNTSPSSQVDNIVGLQSDANSVLLDHTHTDKQKKKKIKHKLIEQTEKELTSEVEDNVQPFQFIELRAMDLPSKRITNKKLKDRKRTGVSSSDAVLKHIDDGPSDMRENNSIQTDKIEHLQTSEEMTRCPSPRLSSDKKRKKKYVDTNLDASSGFQFNWSNGMAKEYSKNSTNISSLDNMHTSKQKKKKKQKLKEQKNVESVGDNVYSLEPDQFSGLQITEIKTKKKDKKRTKQANVEENDLKGILSNKAFKASQTYQLEHIQTSEEIKGRSPNAASKSAKKKKKKKNETKNPQYESVNLDLSLAKEDRTTTQNHTEETQGDGNAVEHLEMNPAGLIKVSKKKKKRENAGIVQLDNIIGLQSGSSTDVKSSVLSDSTDTNKHKKKKRKTLKEQENVEAEGDDVQSVEPDPFSGLQITEMTTKKKRKHKRCEEQRCLRGVSSHEAFKAPPTNLLQHIQTSEEISQCQSPNVAALENGGSPYQLENITEMQPGNSIDINSSEILYSTCTHKQKWKKLKQQENVEADANDVHSAELNLFSELKISEPTTKKKKHKKCVEKCALKDISSNEGIKAPQTSQLEHVQTSKEITQCQSPNAATLKSEKKKKQKRDETEVPQYLDASSVSQFDDVTRLKKQAKVDRTTTQNSSEETQNDDISSKQLEMNPAHLIKVSKRKKKREKAGSPYKVDKIVGLQSGNFTDVNFSQLSDSKRTDKQKKKKKIKLKEQENAEADVDDVHSVELDQFSGLQITKPTTKKKRKHKRCVEESGLRDISSNEAYKAPQTNQLEHIQTSEEITPFQAPNVAALKSAKKKKKKRDKTVEPQCLDASSVSQFDDVKTRAKEDQTLTPNSSKETQGDDSAVECLETNPAGLMKVSKKKKKRENAASPYKVDNIVGLESGNSADVSSSVPSDSTDTNKHKKKKRKKLKKQEIVEADLQTSEEIIQCQSPNVATLKSVKKKKDETKEHQRLDVSSVSQFDDVSRLKKRAKEDRTTIQNSSEETQSADISSEQLEINPAHLIKVSKRKKKRENGRSPSQVGNIVGLQSGNFTDISSSVLSDSTRTDKQKSKQKKKLKEQENVEADANDFHSAEPDQFSGLQITEMTTKKKKKHKRCVEESGLRDISSNYAFKAPQTNQLEHVQTSEEITQCQSPNVAALKSEKKKKNKRDKTDKPQYLDESSVSQFDDVKKRAKADRTTTHNSSEETQKDNISSECLELNPAHLMKISKRKRENKSLGLLSENTADLNSSSLLDGTDTDKHKKKKRKKLEGQENVEADVDDVHSAEPDQFSELQIPEMTTKKKKKHKRCVEESGLKDISSNEALKALQTNQLEHIETSEEMTIKTVKKEKKKRDATEEPHYKSVDLDVSPTESTTEAKLNPTKHKKKRKQSFSGSHDAHEAPERKRKKDRN", "length": 2809 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0MGZ5-1", "protein_name": "Heparan-sulfate 6-O-sulfotransferase 1-B", "gene_name": "hs6st1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNDTERNMVERTSKFLLIVVGSVFFMLILYQYVAPGVINFGSPHGYLLGEEDMTIFPTPDPHYVKKYYFPIKDLERKIDFEIKGEDVIVFLHIQKTGGTTFGRHLVQNVRLELPCDCRPGQKKCTCYRPNRKETWLFSRFSTGWSCGLHADWTELTNCVPGVLNKRESKSKKMRKFYYITLLRDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQQFMDCPYNLANNRQVRMLADLSLVGCYNLSTVPEKRRSQLLLESAKKNLRDMAFYGLTEFQRKTQYLFERTFHLKFIRPFMQYNSTRAAGVDLDNDTIQRIEELNDLDMKLYDYAKDLFQQRYQYKHMLDRREQRLLRGHASFHSPFREDGAGGEGTARLPTEDYMNHIINGW", "length": 407 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A1EC97-1", "protein_name": "Dual specificity phosphatase 14", "gene_name": "Dusp14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRASVASNRHLLQARGITCVVNATIEIPNFNWPQFEYVKVPLADIPHAPIRLYFDTVADKIHSVSKKHGATLVHCAAGVSRSATLCIAYLMKFHNLCLLEAYNWVKARRPVIRPNLGFWRQLIDYESQLFGKSSVKMVQTPYGIIPDVYEKESRHLMPYWGI", "length": 198 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A1XQX2-1", "protein_name": "Neurexin-1b", "gene_name": "nrxn1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMILHLGAHLLFIGLIVCKANAGSSLRFTGSDEQWVAFPMWNACCESEMSFSVKTTHLNGLLVYFDDEGFCDFLELHVHVGKLRLCFSIFCAESTCVLSDVAINDNRWHSVSIMRNFRNTTLIVDDEVKWEEVKSKRRDMTVFSHLFLGGIPSELRSVSLQLTSKTVKDHTSFTGWIMDVKVNDSEPAIISSAGVHEDLCGSENTCLNGGVCSVVEDKPTCDCSQTGYQGKDCSEGLAHLMMLDRGMEEYVATFRGSEYFCYDLSLNPIQSSSDEITLSFRTLQRNGLMLHTGKIADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNEWHDVKVLRNLRQHSGVGYAMVTISVDGILTTTGYTQEEYTMLGSDDFLYVGGSPSTADLPGSPVSNNFMGCLREVVYKNNDAELELSRLAYQGDPKLQIHGVVAFKCESVATLDAITFETPESFLTLPKWNAKKSGSISFDFRTTEPNGLLLFSCGRAKQHNKEAKSPVTLKVDFFAIEMLDGLLYLLLDMGSGTTKTLALNKKVNDGEWYHVDFQRDGKSGTISINSVRTPYLCPGDSELLDLDDPLYLGGVPESSSGTVFPTGAWSALLNYGYVGCVRDLFIDGRSVDVRRAAELQRAAGVKPSCGKEPSGKCVSEPCLNRGVCREGWSRYICDCTGTGFLGHSCERDATILSFDGSKFLKVQFSAAMHTEAEDVSLRFRSLRAYGVLMASTSTHTTDTLRLELEAGRVRLTVNLDCNRINCTTSKGPESLFAGQNLNDDEWHTVRVIRRGKSLKLSVDDLPTVDGEIPGDHTQLEFHNIETGIITGKRQLPTMPSNFIGHLQSLMFNGKPYIDLCKNGDIDYCQTNAPIGFKSIIADPVTFKSCSSYVTLPSLQAYYYMYLFFQFKTTSADGLILYNSGDGNDFIAVELVKGYLHYISDLGNGAHLIKGNSIKPLNDNHWHNVMISRDPNNLHTVRIDTKTTSQTTLGAKNLDLKGDLFVGGVPEQMYKDLPKLVHAKEGFQGCLASVDLNGRLPDLMTEALVCIGQIERGCEGPSSSCEEDSCANQGVCLQQWENFTCDCSMTTYAGPLCADPGSTYVFGRQGGVITYSWPPHDRPSTRVDRLALGFITLMEDATLVRVDSSAGLGDYLKLHIVKGNVVAVFNVGTYDINIEENGKLVNDGNYHIVRLTRSGGNATLQVDDLPVIERFPPGHIDSHRLGTGRLPYRRLVEESLPKNGRQLTIFNSQMTIRIGGWQKQQVSGFQGQMSGFYYNGLKVFSMAADGDPNVRMEGSVRLVGELQSSSTPHGGATVYQSSVTEISSTTSNTITITYSTPADEQQTTDELLVASAECPSDDEDIDPCEPSSGTLCCFVPPAGPTGPAISSFPGPAEVFRESNGTTGMVVGIVAGAALCILILLYAMYKYRNRDEGSYHVDESRNYICNSNGAALKEKNTADDDSGSKSKKNKNKEYYV", "length": 1470 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A2A7I1-1", "protein_name": "Zinc finger protein 978", "gene_name": "Zfp978", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFAPHQESGRRTTKRMSASLENTAQCLLTFKDVFLDFSSEEWECLNFAQRTLYMDVMLENYNNLLFVENHCICGNYEKEKVVEQDTQHIFNEHGHIQEKSFKCNESSNIIHESSESTPHKTNHRDATLQSSNLKRHKTGTTKQVCTYKDCVNCLKGSSIISLNQGTHVEKKEHNRNKNLDEVLVSKHKPIVRQNNSEMNTYTCGEFDKCFTQSDNLQSQQRIYPGKKSYKYSESDKCFTQPSHLSIHHTIHSGEKPYKCSECDKCFTDKCTLRKHQRIHTGEKPYKCNECDKCFTDKGSLRVHQRIHTGEKPYKCSECDKCFTQTSHLSIHRRIH", "length": 335 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2A8N2-1", "protein_name": "PRAME like 25", "gene_name": "Pramel25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVICGHCPDQDESLEEVTEECYSPPTLQNLAIQSLLRDEALAISALTDLPQSLFPVIFEEAFTDGHIGILKAMIPEWPFPYLSLGKQINNCNLETLKAILEGLDILLAQKVQTSRCKLRVINWRDHDLNLWAGSHEGEGLSEFTTEKQPIENSPGCEVKKELKVMTEVLRMKGRLDESTTYLLQWAQQRTDSINLFCRKLVIEGLTKASVIEIFKTVHADCIQELILRRICIEELAFLNPYLKLMKRLFTLTLDHIIGTFSFGDSEKLDEEIIFSLISQLPTLHCLQKLYVNDVPFIKGNLKEYLRCLKKPLETLCISNCDLSQSDLDYLPYCLNICELKHLHLSDICLRDLLLEPLGFLLERVGDTLKILELESCCIVDFQFSALLPALSQCSHLREVTFYDNNFSLPFLKQLLHHTALLSQLISECYPAPLECYDDSGVILTHRLESFCPELLDILKAKRQLQSVSFETTQCSKCGGCYIYDQETQCCHFVELLLA", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2A9Q9-1", "protein_name": "MAGE family member B5B", "gene_name": "Mageb5b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRGQKNKHHRNRLKNKKHNQEKVHPQKDESQEKGHHKRDDFQDHKEARDNAAVEEKSSCSSPSVPGETLEKPPASKTSSDAGWLSCVSSPATVCGDELEFDDGTYFHCGGNSLYSEYRTCQENPCKHCLDMYVNLVEQYVLYKFKMKKLIDRNKLIDLIEPKYRYNFSDIFKRAFENIEIVFAASVIEIDSTNHVYDLVSKLKLPNKGRVCPGRGLPKTGLLMTILAMIFMNGTSASEEDIWKFLNYMQVYPGRKHFIYREPRKLITQDFVKLKYLEYKQISLSDPPCYRFQWGPKAYTETTKMKVLEFMAKGSGVEPSTFSVQYTEALREENQKTKIRKWYPILAQKHCPGHSHQHVQKVMKPQ", "length": 366 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2ADW8-1", "protein_name": "Predicted gene 15128", "gene_name": "Gm15128", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANREDEIRQLRYLEAANSEEEYNEENDIQSESSRGQAFFPGHPRGRGHRRDSRGRNGHFFRQRFSANHPLLHLTRQVNLESLTRRNGNQSEERQLQQERIQLFFRSLHGLSQSHDHHIGRSHGHDSRRSRNRFRRAPVQSERSHVYSGRTNNYTDRPQHDLSNRPHNQLSVRPHPDLSGRPLHDYSGRPHQNHAVRLQHGHSDRYHLTHTERVLPNNSGIAHPGHTERDNQVQRGRAHDNQSGLAHHNHDGRSHHDHSGRAYHGHARRAHNNQSWRSDNNQSWRDLNQSWRGQNNQSQRGHDNQSQRGHDNQSRRGHDNQSQRGHDNQSQRGHNDQSWRAHNIRSRRDRYHTSLRSSSIQSWMLHERERYHGPRGRNGPRDASPPGSEPEIDRSSAIRERTDYLWVQEHRRNETVELNVGLEDGYSSAEESDESFDRLTCRSMLDTLY", "length": 449 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2AGW6-1", "protein_name": "PRAME like 22", "gene_name": "Pramel22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHRLLREEALAISSLKDLPNMLFPVLFEEAFIFGYTKILKAMIPEWPFPYLSIAVLIDNCNLESLKAVLEGLDILLAQKVHSSRCKLKEISWRDTNHGLDGIRPGSHEVEGLSEFMEQKHPNCVEKKELKVTTELSVMNGRLNESDTYLLEWTQQRKDSIHLFCRKLVIQSLTKATVIEIFKIVNADCIPELELCSLCLEDLAFLNPYLRQMDNLLELTLDHITDSLSIGDSEMLEERMITLVSQLPTFPCLQKLCINDVYFIYGNLKEFLGCLKKPLVSFCISNCELSQSDLDYLPYCLNIFELKCLYIINIHLQYLCLEPLGFLLESVRHTLGCLALKSCNMGEPHFKSLLPALSQCFHLTDVNFQENELSLLSLKQLLQHTSKLTQLSYEMYPAPHECYDDRGVILSHRIEQFCPEVLDMLRAKRQPKDINFVTTQCSKCGIYYVYDLETQRCRFLK", "length": 460 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2AGW7-1", "protein_name": "PRAME like 23", "gene_name": "Pramel23", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNVNSPPTLMKLASQRLLREEALAISALKDLPNMLFPVMFEEAFINGHTKILKAMIPLWPFPYFSLGMMIKNLTLDTLKAVLQEIDILISKVVHSSRCKLKEIKWKNTDYGLQGIWPGSHEFDGLSEFMEQKQPDCGVKKELKVITHLKLMEGSLDECATYLLQWAQQRKDSIHLCCRKLKIQGSINATVIEIFKIVHADCIQELELCCLCLEDLDFLNPYLKQINNLIRLKLDEIKGTVSMGESRNIDEEKVITLISQLPTLQHLEKLCINDVSFIEGNLKECLRCLKKTLEILCITNCYLLQSDLDYLPYCLNILELKCLDFSNIPLSHLFLEHLRFLFERVRHTLECPILKSCEMGESQFNSLLPAISQCCQLTEVNFYDNELSLIFLKKFLHHTAKLSQLTYELYPAPLECYDNRDIILSHRLENFCPELLNILRAKKTAQGGHLCYNPML", "length": 455 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2AHC7-1", "protein_name": "SSX member B14", "gene_name": "Ssxb14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METVISCEKIPMEVLHKPKNICKAFQDISTYFSGEEWGKLTEWQKSAYMYMKRNYTRMTGVTVNQPVFMSGKEQAKQSLVKGIEVHDSEDECFEESFGVTPRKRMKLTSVTISIHNVEGSLASGENDSNLAETDGIQVNVWSHRLRERKYRVIYSEISDPEEEEDDDY", "length": 168 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2AK42-1", "protein_name": "Pre-mRNA-splicing factor CWC22 homolog", "gene_name": "Cwc22rt5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKSSVAHMKQSSGHNRRETHSSYCRSSSPEDRYTEQERFPRDRDYSDYSRSDYERSRRGYSYDDSMESRSRDREKRRERERDADHRKRPWKSPSPDRSPARGIRQSSPQEEPTWKKKKDELDPLLTRTGGAYIPPAKLRMMQEQITDKSSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLKECGLKLAQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFKDHPVILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKYKAIKKEILDEGDSDSNTDQGAGSSEDEEEEEEEEEEEEEEGEDEEGGQKVTIHDKTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFAESQTKELCNMILDCCAQQRTYENFFGLLAGRFCMLEKEYMESFESIFKEQYDTIHRLETNKLRNVAKVFAHLLYTDSLPWSVLECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLNARLKDETLQPFFEGLLPRDNPRNTRFAINFFTSIGLGGLTDELREHLKNTPKVIVAQKPEAEQKKTALTSSSSESSSASDSSDSDSDSSESSSESSSEASDSSSSSSTQSSTSAKGTRKKRQGKARGEEVDKLARGHQALERRQGGREDQRHQEGRTERARSERHRAQNSRDADWRDSLAKHIDDRSHENSHSRVGNGREQGSHREPEDRHGEPKKKQREKRFFL", "length": 830 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2ANE0-1", "protein_name": "Reproductive homeobox 2F", "gene_name": "Rhox2f", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERQSINYLLDVGPEEDEENANGVKTLMVLLAGDGRNEGESGRGLPGSGASAAEGYRAGEISAGGPAAQVADLMDDSNQEDLGATACDQEKEKQPEEPVPDSMGDLENVKRVSGPWSTVNPVRVLVPKFRHLWRHSFNVLQLQELESIFQCNHYISTKEANRLARSMGVSEATVQEWFLKRREKYRSYKRL", "length": 191 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2ANE1-1", "protein_name": "Reproductive homeobox 3F", "gene_name": "Rhox3f", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSMKPERSMSNWIHSNVEPAGRNLFQVNGHRSALLPELPQDYHRASRSVNGCETKMDNTQGTKVLPAEEARNEEDGGQVESALGATAARGRGKEALNGESPAAAGTAGLVEEDRNKEDGGTKGGEKNEQEVREQIPEHVEGESDQAEALRQVPRRRLHHRFTQWQLDELERIFRMNYFLSLEARKQLARWMGVNEAIVKRWFQKRREKYRWYKRL", "length": 215 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2ASJ1-1", "protein_name": "PRAME like 14", "gene_name": "Pramel14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDLEAPPTLLQLAAQCTVRKEVLTISVLQNLPMKLFPPLFKEADILRKAKMIKLLVEYWPYPSLLVGLLIDKTNLETFQAILEGVGTWLKRKYRPRMGKLQVVDLRNGHHDFWDMLAGREGGDQLVETMPEKQEVEGHSRRQRLRVFSDLSFKSSRHEDKQQTHLLQWAKDREGFLHLCCEKLEIGALGVSKVKKVLKLLQPEFIKELELNTVGNLSKLTKLVPCISKMRNLQKLMLVRIFGRHTYTPLEERNVTKILSLFPKLSYLQHLTIDDVYFLRDHMNELFRYLEAPLLSLTITLCQISQSDLESFSQHWNYGQLKHLCLKGVSLSTLNVTPLKFFLESVADTLQTLELEDCRMKDSHLRILLPALTKCTRLTSINFYDNNISRDVLQDLLHRTANMSQLTMELYPAPVEVYNEWSYVQVERFSQLCAELMNTLITVRRPKSVCFGTYSCYDCDTHCIYGNQTTFCECLE", "length": 475 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2ATW2-1", "protein_name": "Olfactory receptor", "gene_name": "Or4x15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADIHNVTEFFFLGLSSNQEVQRVCFVIFLFLYMAIVLGNLLMVVIVAVSRNLGSPMYFFLSSLSFVEICYSSTTAPKLIVDLLAEKKSISVWGCMAQLFFMHFFGGIEMFLLMMMAYDRYVAICKPLHYTSIMNRQVCTVLVGMAWMGGFVHSLAQVLLIFRLPFCGPNIIDHYFCDVLPVLKLVCSDTFLIGLLIVVNGGTLTVISFVVLLSSYAVILFHLRTQSAEGRRKALSTCGSHVTVVVIFFAPCVFIYLRPTATLPIDKMVTVFYTVITPLLNPIIYSLRNAEVKKVIKILCTRATKVDKK", "length": 309 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2AWL9-1", "protein_name": "Reproductive homeobox 2C", "gene_name": "Rhox2c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERQSVNYKLDVGPEEDEENANGIKTLMVLLAGEGRNEGESGRGLPGSGASAAEGYRAGELSAGGLAAPVADLMDNSNQEDLGATGCDQEKEKQPEEPVPDSMGDLENVKRVSGPWSTVNPVRVLVPKFRHGWQQSFNVLQLQELESIFQCNHYISTKEANRLARSMGVSEATVQEWFLKRREKYRSYKRL", "length": 191 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2AWM0-1", "protein_name": "Reproductive homeobox 3C", "gene_name": "Rhox3c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSMKPERSISNWIHSNVERAGRNLFQVNGHRSALLPELPQDYHRASRSVYGCETKMDSTQGTKVLPAEEARNEEDGGQVESALGATAARGRGKEALNGESPAAAGTAGLVEEDRNKEDGGTKGGEKNEQEVREQIPEHVEGESDQAEAPRQVPRRRLHHRFTQWQLDELERIFRMNYFLSLEARKQLARWMGVNEAIVKRWFQKRREQYRWYKRL", "length": 215 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BED8-1", "protein_name": "Predicted gene, 58953", "gene_name": "Samt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDQLIVDTRSVIYRFINEKDCIYKLSGLLSSLAAFMLEVLIASILSWRLWEFDSNVVQFVSFGLFEAYYPQQFNISGTLTKMLVYTPIDSTWNISTEFMYAQNLVVWAILMKPVVLVFCVMAIKISCTKNPLVEMQIYCYKISALILSVSSMFTFVSVIWNHMVDFYGHTTLDFPSDFPVKKEALTSKHLTVVLPVGLLIATMSLFGVIMFLSEISDLKLKRPVKANDASKMGLLDA", "length": 237 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BEE3-1", "protein_name": "Spermatogenesis associated multipass transmembrane protein 1d", "gene_name": "Samt1d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDQLIVDTRSVIYRFINEKDCIYKLSGLLSSLAAFMLEVLIASILSWRLWEFDSNVVQLVSFGLFEAYYPQQFNISGTLTKMLVYTPIDSTWNISTEFMYAQNLVVWAILMKPVVLVFCVMAIKISCTKNPLVEMQIYCYKISALILSVSSMFTFVSVIWNHMVDFYGHTTLDFPSDFPVKKEALTSKHLTVVLPVGLLIATMSLFGVIMFLSEISDLKLKRPVKANDASKMGLLDA", "length": 237 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BEI6-1", "protein_name": "Myb/SANT DNA binding domain containing 5 family member 10", "gene_name": "Msantd5f7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQREDNRVQSVRSDKEANRRRRLRQEGQSSSGPCDSPWTEDEIWILLQEWAMVEYELGDPGNKMHAKAKSLSRRLSNRGLRKSKNSCLDVMVKMKDLHTRLCNERPRAYRLYSTYEWILYEILGHPRSQGGYVPGLWFDGHSKPPASYAPSLCIGGAISPGPSFSPWTDPEIKIFLQEWQVVEREIGHPGQKIKQKSSLVCQRLYHRGLFKDIQSCLDLMWTLKDLHSTLSRERSRTVPLFSPYRDYLERIFDPKCQRGHVPGALYNWSGYHRPSSSPQTPMVMPSPVYQPWDYGMSASSGQLHGNPSLIMSSQDSLVPRWDAWNATYPLPVQHVLLASLSGDNNFQLAWSPRDESSSPQ", "length": 360 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BEI8-1", "protein_name": "Myb/SANT DNA binding domain containing 5 family member 8", "gene_name": "Msantd5f8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQREDNRVQSVRSDKEANRRRRLRQEGQSSSGPCDSPWTEDEIWILLQEWAMVEYELGDPGNKMHAKAKSLSRRLSNRGLRKSKNSCLDVMVKMKDLHTRLCNERPRAYRLYSTYEWILYEILGHPRSQGGYVPGLWFDGHSKPPASYAPSLCIGGAISPGPSFSPWTDPEIKIFLQEWQVVEREIGHPGQKIKQKSSLVCQRLYHRGLFKDIQSCLDLMWTLKDLHSTLSRERSRTVPLFSPYRDYLERIFDPKCQRGHVPGALYNWSGYHRPSSSPQTPMVMPSPVYQPWDYGMSASSGQLHGNPSLIMSSQDSLVPRWDAWNATYPLPVQHVLLASLSGDNNFQLVWSPRDESSSPQ", "length": 360 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BFR3-1", "protein_name": "Histone H2A", "gene_name": "H2al1j", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKKMQRRRRQKRTHSQRGEFPLSLVDRFLPEGNHSGRLSSSAPVILDSVLEYLSSNILELAGEVAYTTGRKRIAPEDVGLVVQNNEQLCQLFKPGATSVFDPPEPDDN", "length": 109 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BFZ7-1", "protein_name": "BTB domain containing 35, family member 9", "gene_name": "Btbd35f11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BH64-1", "protein_name": "Secretoglobin, family 1B, member 30", "gene_name": "Scgb1b30", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKLTGALLLLGAALLLTSEGDCGLCPVLQKKVHKFFDGTTEEYVEYLKQYNNDPLVLENAANIKKCSDRMLAEEDKTQATNFINKVTGSRSC", "length": 92 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BHG6-1", "protein_name": "BTB domain containing 35, family member 7", "gene_name": "Btbd35f7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLSCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYRDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSFGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BI40-1", "protein_name": "X-linked lymphocyte-regulated 4A", "gene_name": "Xlr4a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASKIKGRPPKQPKVTPALPSDDSQQLHENNPGNNLALETCGESSSSHGTGGPKPGPSKKTLNERKRKYGVSVNKTVQNIEWNVDHFLKVQHERRQELYKDYSHQFLTLVMMWNIDVDQIKKQAGKLSDILDEQQKLFQQFQSIHMQKIEEFKELCDRHLKNLQAIKCCRRKAIIEEARKLMDYLEKTVTEETVHVNKQEAKDGVQSSLLSLLIS", "length": 215 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BI45-1", "protein_name": "X-linked lymphocyte-regulated 5A", "gene_name": "Xlr5a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSNKEQKAMKKSGKHQRVHKTLPSDDFKNSDEVNPADKPAVGTSGMGSHSSGSDMQEAREPVQKKMQDFKGDDGTGLLMEKKKQFEEDVNASFRSLNENLQSILKAQQNSRQELKSLYCERFGSVYHNWLVEMDRTRDQEEYFSFITQQQMKILQTAIEDHETKLKNAKDMCDTFLKKANDLSKRQKTFIGGQHTIVEKEISKVQNRVIMETQDQDISMVETYLQSLIHESSEETI", "length": 236 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BI50-1", "protein_name": "X-linked lymphocyte-regulated 5B", "gene_name": "Xlr5b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSNKEQKAMKKSGKHQRVHKTLPSDDFKNSDEVNPADKPAVGTSGMGSHSSGSDMQEAREPVQKKMQDFKGDDGTGLLMEKRKQFEEDVNASFRSLNENLQSILKAQQNSRQELKSLYCERFGSVYHNWLVEMDRTRDQEEYFSFITQQQMKILQTAIEDHETKLKNAKDMCDTFLKKANDLSKRQKTFIGGQQTIVEKEISKVQNRVIMETQDQDIAMVETYLQSLIHESSEETI", "length": 236 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BI74-1", "protein_name": "SSX member B6", "gene_name": "Ssxb6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METVSSCEKIPMEVLYEPKNICKAFQDISTYFSDEEWVKLTQWQKSAYVYMKRNYIRMTDLGVTVNQPVFMRGKEQAKQSLVEGIEIHDSDDECFEGSFGVTPIKRMKLTSVTISIHNVEGSHDSGENDSNLAETGGIQVNVWSHRLRERKYRVIYSEISDPEEEEDDDY", "length": 170 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2BIM8-1", "protein_name": "Major urinary protein 18", "gene_name": "Mup18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMLLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNANRCLQARE", "length": 181 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2CEK7-1", "protein_name": "Major urinary protein 14", "gene_name": "Mup14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIRVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNANRCLQARE", "length": 180 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2CG71-1", "protein_name": "BTB domain containing 35, family member 19", "gene_name": "Btbd35f20", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLQPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSVYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKMRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTLKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2CG92-1", "protein_name": "BTB domain containing 35, family member 10", "gene_name": "Btbd35f10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIHALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2CGC2-1", "protein_name": "BTB domain containing 35, family member 3", "gene_name": "Btbd35f4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQRMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 496 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A3KG49-1", "protein_name": "PWWP domain containing 4C", "gene_name": "Pwwp4c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDSSEYVLCGWKSQLCPARVLSRPRTPAHSKRRGVPFLEVQILPVGEKRRVRSSKVRPLAKSEIISINSLAGKESRGRGSPGQTRASRRALKVALDGLGEGSSFFQGGRAGSRRTSTLAPKVPKEQASSSSSSLGQRLRLRLRQLLPLSLCQRLHLHLRLRLHLHMHLCLQGRNQKGQGLSQRSPGKRVRPDPGPVMMGSQNVPAVPVGEAQAHTAAGLPRSEVEGDVLRGTRVWPSYSKKTPLGKAGGNPGKRKPGTGKRKLRSLSAPASRKGTRSKTEQQAASGPPRHISISPKALKQRVRCAGLEIRAAGAQRKTALAENKDHPGLGTPKPDSKRASAACMPPVLRLRRSLRIASRKKKTHVLCALCGLPEWEPQVHSKVTNTRFKRRGARVQKDAKATNVVSAQEPSTIEQGTLVWFKFQDLPFWPAVVKSVSKIDKMARVLLIEGNMQFERRGIRVPLRKLKHLDCGEKVSLVRRASRLYAQGINWCFSVIDHYREGLSRGSLLGSFMDYYTTQASYPLRRAVQEGDLHIDFPKVSYAELEDWEEETALGGKGPYKKLLPDRMRAAWDRANQKLVDFIVKRKGADQHLLDIVKGRKPSRWLDDLWKSKREVFCIETYLEDDDQLHLVARHLQEVAKEADEALLSLARGDKVRFTMEVLFPEAIIYSIAALDELSYKEAEEKYLRGPPVHYREKELFDKTILKAARKRSAARIRAARDPPVPTP", "length": 728 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A5WVZ0-1", "protein_name": "2.7.1.138", "gene_name": "cerk", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEKQSTLLCSELSVQRRLYEVTLNCAILAWKDVQNAKKHTGRAIYGAVKAGSHCVPVCEIIAVQEKEDDSPCKDTGKWQKVPQSPTDSCQHAFTVYYVERTRQHCWRCSNVTFQYSEHSLCLLWIQTIKEQLALLSAQSTEELAGVHQPLRRKTTRQADLRPQSGPHLFPGFHFHRRDWPHSFSAHPSELRFYIIADGKEPVMKCTGDCFSPRVQLHHLMQLIDGLHQASRKMQFNCQMNIMMFLPPLYHQPGNNGFSLFVSIVTEHANHARDHLKAEADLKKYDGVVCVGGDGMFSEIMHGLVSRTQQDAGVDENSTEETLIPCGLRIGIIPAGSTDCICYATVGSNDPVTSALHMVVGDSQPMDVCSVHSDDRFLRYSVSLLGYGFYGDVLKDSERKRWMGPARYNISGVKTFLSHRYYEGTVSFLPAEENLGTPRDKVQCRSGCSICRRSSSDKLLSKEDEASVSDVDCRDTWTVIRGKFLAINAANMSCACPRSPKGLSPSAHLADGTTDLILVRKCSRVDFLRHLLRHTNKKDQFDHSFVEVYRVKQFRFTPRFQECGSEMDLRESRAGGKHFFCQICRENRACGCMSSQSNWNCDGEILPHTAIQVRVHCQLIKLFARGIEEQPVFEDLYAHCQLNNPPNHEP", "length": 649 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A5WWD5-1", "protein_name": "alpha-1,2-Mannosidase", "gene_name": "man1b1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLPSTRKDFVSLTLSESGSYSNSKQWRRQSCWRKWKQLSRLQRSLILLTLMLLLVCGIATSPTLIGHWRGMNGDDVKNSFVVDLKNEYRSILPEPPSERKDFDRRGAFGLEKLLQGKVNVSGVLGDQNHGLDLKNADKGSEGQKPIISWRGAVIEEEQASDTDTKDTENQGDPASLALAESRLEAVREAFRHAWKGYKDFAWGHDELKPISKSYGEWFGLGLTLIDALDTMWILGLQEEFAEAREWVAKELSFDKNVDVNLFESTIRILGGLLSTYHLTGDNLFLDKAKEIGFRLMPAFSTPSKIPYSDVNIGKGTAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDPKYKLAVMEVMKQVHKLDGKQDGLVPMFINTNNGLFTHQGIYTLGARADSYYEYLLKQWIQGGRIEQELLEDYLQAVEGVKKNLLKKSTPLGLTFVGELSHGHFSPKMDHLVCFLPGTLALGVHYGLPADHMELAKQLIETCYQMYAQMETGLSPEIAHFNMHDGSTQDVDVKIADRHNLLRPETVESLFYLYRLTRDKKYQQWGWEILQNFNKYTRVPTGGYTSINNVRDPSYTSPRDKMESFFLGETLKYFYLLFSEDPTLISLDKYVFNTEAHPLPVWPQAE", "length": 632 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A6NCW0-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein 3", "gene_name": "USP17L3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSSETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTLPLANYMLSREHSQTCQRPKCCMLCTMQAHITWALHSPGHVIQPSQALASGFHRGKQEDVHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVKQALEQLVKPEELNGENAYHCGLCLQRAPASNTLTLHTSAKVLILVLKRFSDVAGNKLAKNVQYPECLDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHDGHYFSYVKAQEGQWYKMDDAEVTVCSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRAKQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVGKVEGTLPPNALVIHQSKYKCGMKNHHPEQQSSLLNLSSTTRTDQESMNTGTLASLQGRTRRAKGKNKHSKRALLVCQ", "length": 530 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A6NCW7-1", "protein_name": "Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4", "gene_name": "USP17L4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSSETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTLPLANYMLSREHSQTCQRPKCCMLCTMQAHITWALHSPGHVIQPSQALAAGFHRGKQEDVHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVKQALEQLVKPEELNGENAYHCGLCLQRAPASNTLTLHTSAKVLILVLKRFSDVAGNKLAKNVQYPECLDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHDGYYFSYVKAQEGQWYKMDDAEVTVCSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRPATQGELKRDHPCLQVPELDEHLVERATEESTLDHWKFPQEQNKMKPEFNVRKVEGTLPPNVLVIHQSKYKCGMKNHHPEQQSSLLNLSSMNSTDQESMNTGTLASLQGRTRRSKGKNKHSKRSLLVCQ", "length": 530 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A6NDS4-1", "protein_name": "TBC1 domain family member 3B", "gene_name": "TBC1D3B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSASRPVPASRGRKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF", "length": 549 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A6NJZ7-1", "protein_name": "RIMS-binding protein 3C", "gene_name": "RIMBP3C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPDSYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGMVDRGLCQMVRVGSKTEVATEILDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTMSSTVTFDTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVADATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTSKSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLKEEQEALCLDLRGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPRGGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLIIPQGSSLVLQGNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHLLDHMSLHGH", "length": 1639 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "A7TZG3-1", "protein_name": "Selection and upkeep of intraepithelial T-cells protein 9", "gene_name": "Skint9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESSASCLPGFFMSFLLLQNTVLTQAMRSDIKINIQVPDTEGLLLECTSGSLIPPAEMTWRDSNGNIIPHSTAFNSQDRDGLLYLKSSILLKNRAKGPITCSIYNVTTNQEKKRSIVLPDALFKSENMSLMSNKFSCPSIYLITIIFLNFLRGILVFCCLRRKPVCFRNLMSTVMEALYSKMGVCCLLIWECLLLVLYIAFLPIYVSFRSRAFLLDDTYPLYTNWLWNICIILTVIMVLFPGLILCLLWTLNCYGQVSSLPPTSMELSTKDSEQNSSKSDDSQENYDVNCKILETCESKIFSQHQESCEDDTASTLFIS", "length": 319 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A7XV14-1", "protein_name": "Selection and upkeep of intraepithelial T-cells protein 11", "gene_name": "Skint11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPSASCLPGFFMVCILLKITVLTQVMSLDIQINTQIPDTEEGVLVECTAESLFPPAEMTWRDSKGNIIPPSSTFDSQDRAGLLCLKSTILLKNRTEGPITCSIYNKTTNQEKRRSIILSDVLFRPQYMSLMSNNLLYLGIYLIFILFLNFLKGILFCLTKRLVHFRKRMIKIKKVWSNKTRACCPLIWEFLEIVLFIAFLPLYLMFRIRVFTLDEAHILYNNWLWKVCKTLIAMMILFTVLILFLLWTLNRYGKMPCLSSMNIDVSTHDAEQNSSKSAKFQENYDVAGQMILETYEETIFCQHQESCEEYNYDPLLLSSLDALGTCEDEKFSQHQESFEEDEDLQSFSDFKIELYSKLGNLTH", "length": 364 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B0BMZ6-1", "protein_name": "Cilia- and flagella-associated protein 119", "gene_name": "Cfap119", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MITPRSSQSLEMKVQTELEHSPKLQEEPDRSPSLVDSSVIRIGTDEQNESPAEATSSPVEVAEDPGANLFPPPLPQPRICMWKYLDIHSMHRLEKAATVEEMREVLAELLELGGPEQSLRDAIILDLFSHALIFCRQQGFSLEQTSAACALLQDLHKACVATPLGNVEECYRYFTSVLFCHGVRRPPFSIDLFKEEQLLALADYVVNTYFRHFKLYKYVFTPQVRLDLSLSYMGLQSLHLWPEEKEDEEATVEQAATPQEEEPEAVTEAEQQPSEVCILQTYIKCQLNKELRQLQQLVEERLKESEERLSNRLAALERPYQTPPSKGKSKAK", "length": 332 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B0G0Z9-1", "protein_name": "Probable polyketide synthase 6", "gene_name": "pks6", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNNLKNIDLIEKGVAIVGIGFRIPSGNNENSICSPDDLFNNLKNGFDGVSSTSERWSDNYHKLGEISSPNAGLLPLNEWKSFDPLFFGINPSEASLIDPQQRLLLKCTWEALEDASIDPISIRGTNTSVFIGASNIDYQHTNKHQDSVLKNAIAQSTCAISNRISYCFDFNGPSLSIDTACSSSLNAVSQGYHSILNGTSDISIVGGVNLILDVEMTKAYSYLSMLSKTHGKCKAFDESGDGFTRGECVGVVVLKNLQDAIKDGNRIYCVINGSSSNVDGNGNMDKVNFYSPSKQSQFNNINSAFKSTNDKLSINDIQYIEAHGTGTKTGDPIETEAISMAFKNRDKSAPILIGSIKSNIGHCEAGSGVASLIKCCLMFKYQCFLPNIHFKNPNPLIKFNEWNLKVVTSPIPFNKRNNEKPVSMMINNFGVTGSNCCLLISEFKNNNNFKENINLESQSVNDRVLIPFSANSSNSLNQYQSKFKNIINNQFNFIDFTAIQIYSKSNYLYQRSVVIASNSNELFENISNKKQIQTKNSIISNMSFKGKNPITIFVFSGQGSQYPKMALELYNNEVIFKKSIDLIDSKLSKYYGFSVWEKVKTIKDDDLTSIHDPIFAQPALCMISVSLFELYYHWGVNPSFILGHSLGEISASYCSGMIDLDTFCYTVYQRSIAQSKTNGCGRMLSINISDEEFKSMYSQKYPQIEIACYNSPQSIVVAGNESILNEISKELKEKEIFTAMLGSLSSFHTSSQQSTKDSILQLNIESNQPKVPIFSTVTTNLFNESNRFNSQYVYDNIIKPVKFTQTISNIYKHIESNQLDNDIVFIEIAPHPTLSFYIKQMVPSSLNESVSVYSALHKKKNDVEEFQQTISNLYCQNGYNINFKCQFNNKKSNLNIELPLYQWSDELYFAQNQVLEQHRKGGPPIDHLGLSNSYYSPFKNSYKTLIDINYKPFQYLKGHMVKGKYYFPGCGYIDNIIQLYKNQDIFISFIEFKTPLILIEGINQYLQTNIQQTGKSEYRAQFHFKDHKSNEWIQSSNSNFQLLDHGNDIPSNYNIKEIIKNKCNLSKLTKNELYKNIKSKTGLNYTGVFQGVTECYIGDNCTLSVVSLESQTNSFLNIPILDTCLHGMLILINDQCQIVFDKAIGFKYYSSNIPADFKENKDSFYVYSNLRPRVGGDSYHGTIIVMLSDGSVLYEIEEVVCKSLIPIKDSLKIEYPNDELYKVHLQSKDSPIPTPSSFKSIIYENDFFQSSLNIPEDLFKYISTLFYKDIIKRCPEININKINSHSVNEIISSFSKISKHERLFRFVFETIKENGILNSFEEKDDTYFEFNKVIIKSSRIISKLLFPLENDNDNEDLPQSLFQNGLMDKIYKCSYLRKKNQVISHVIKHSIKEIINNNIIIRILEFGGGTASLSVEVIEEIVTLLQENPNYQVEIEYTWSDISPAFIADAKNKINKIINDAAITNGLNVIYHPLTIGESLIETQSIKPSYYDFVIMSNVLHVVKDIKQAVEQMYQLLTTNGQLVFLEPPYKSVLNDSIVGSFEQWWSFTDTDIRKDRCGMPQQSWYQLLNSCNFKDIVMSKECIFFGSVIQAQKPPISLLNSQPKYDNIIIYGGSINSSFVENIKLDSNSKSLFQIETIQEFNKLISKSTITNDSIVYFIKTLETLSLDNFKQITLEYIEINQKLLQINSLCKHVLIVSDSRKTNYLASSAIGAARYFDEFPLLKLHTLDFDYDSTQNYINSKNNKMVQFINILTDSKTNVHKEMIIINNKVYYEIVQKEKNLKLKYNSESFENQNNLMCSLSPNLEYQLQSKQIKLRDNQVEVKTIATGINYKDYLNFSGSNSNGDDNTGLPQFGYEFSGIITRVGNNVKDYKVGDNVFGLSNSCTSSHIVTNFKKIQIKPSKISHIEASSIPIDYLTSFMSLFNVGSLNIEDNESILIHLGRDGFGLSTFEILKWKGFKSNLFVTVNSDKTKQYLLKKYGDLITGIYSNTDKSYVAEIKNKLIKLGSKKKGVDLILNTLPSDFMDSNFKLLTKYGRIIDLNSNHLNQSEFLKNINFKYNHGYHNFELSLFQKNKILKCLNEISNAIENGELKTIPIKEFTNLNIKDAIKYITNGNIEKITVSHDHEIYSDIIYRYLDEKEFSILKSNYQINSNNLGKNILITGQSGIILEILKWIIKYSNINTIENVIILSRSSLKWELELLINQTKLSNNNIKFHFKSVDVGDSEQVDNAINDILNENQQIRNIDSIFHFAFQQIACKVQEINMKHLNISHGAKSMGAINLHNQSIKRNWKLINFVMASSALSFIDSTDQCTYACANTLLDSFSKYRVSLGLPSTCINLGLIESTGFVSKNESISVFLDGNGIIPTPINRVLGLLDLQIQNASKFTNSMISNFKPSKFKNNQQISLFLKFDYLMNLKNNSEQTKKENTGNKNIDELFIEKVSELFSMDESKINKNLRLIDYGADSLIIVQLKNWIDKEIGINLITIQQLQNNTINISIKMILNSLMKNNQNKYLPSNRIDYWKNEMKFEESIKPIPNEIRSRNNNSGKIILLTGTTGFLGGFLLFNMLRLDSCKLIYCLIRNKSKSSYPLDEIINNLKYHQLYEKLNKSQISKIIPIIGDLSMNKLGLSNDDYETISKNVNLIINPGADINQKSSYQDCKLVNVNGVKEIIKLSLSSLKQRIPIVNFSSFSVFFNQSLDKNFDESVLPSIDNIDNLPTEYMKSKVVGEYILLEASKNYNIPSILIRPPSIFLNPETGIGHSSDLTLLMIQSCYELGYCPNQILNGFILINTITWLSNNITNIIMNDNCWTNSKMNIYNVHGKQIQSSLIIKPLEKHFNCKQINNNDWIDMVNNSNKKSCIKLKSFHSLENIFKSENKGYKSNESQSISLSTKSLLESMGSYNTDLKITDKMIISHIKHIFK", "length": 2924 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "B0G100-1", "protein_name": "Probable polyketide synthase 7", "gene_name": "pks7", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNNFKNINLIEKGVAIVGIGFRIPSGNNENSISSPDDLFNNLKNGFDGVSSTSERWSDNFHKLGEISSPNAGLLPFNECKSFDPLFFGINPSEAPLIDPQQRLLLKCTWEALEDASIDPISIRGTNTSVFIGSSNIDYLHTNKHQDSVLKNVIAQSTCAISNRISYCFDFNGPSLSIDTACSSSLNAISQGYHSILNGTSDISIVGGVNLILDVETTKAYSYLSMLSKTHGKCKAFDESGDGFTRGECAGVVVLKNLQDAVKDGNRIYCVINGSSSNVDGNGNMDKVNFYSPSKQSQFNNINSAFKSTNEKLSVNEIQYIEAHGTGTKTGDPIETEAISMAFKNRDKSTPILIGSIKSNIGHCEAGSGVASLIKCCLMFKYQCFLPNIHFKNPNPLIKFNEWNLKVVTSPIPFNRKNEKPVSMMINNFGVTGSNCCLLISEFKKQDYEPYENNYKSNNKNILIPFSANSSNSLNQYQSKFKNIINNQFNFIDFTANQIYSKSNYLCQRSVIAASNSNELFEKILNKKQIQTKNSIISNMSFKGKNPITIFVFSGQGSQYPKMALELYNNEVIFKKSIDLINSKLSKYYGYSVLEKLRSIGDDDTTSIHDPNISQPAVCMISVSLFELYCHWGVNPSFILGHSLGEISASYCSGMIDLDTFCYTVYHRSIAQTKTHGNGRMLSINISDEEFKSMYSQKYPQIEIACYNSPQSIVVAGNESILNEISKELKEKEIFTAMLGSLSSFHTSSQQCTKDSVLKLNIQSNQPKVPIFSTVTTNLFNESNRFNSQYVYDNIINPVRFTQTISNIYKHIESNQLNNDIVFIEIAPHPTLSFYIKQMVPSSLNESVSVYSALHKKKNDVEEFQQTISNLYCQNGYNINFKCQFNNKKSNKKIDLPLYQWSDETYFAQTQTLEQHREEGPPIDHLGISNSFISPFNNSYKTLIDINNKPFQYLKGHMVKGKYYFPGCGYIDNIIQLYKNQDIFISFIEFKTPLILIEGINQCLQTNIQQTGKSEYRAQFHFKDQKSNQWTQSSNSNFQLLDHGNDIPSNYNIEEIIKNKCNLSKLTKNELYTHIKSKTGLNYTGVFKGVTECYIGDNCSLSVVSLESQTNSFLNIPILDTCLHGMLVLINDQCQIVFDKTIGFKYYSSNIPAYFKENKDCFYVYSHLKSKSADSYHGSIIVMLSDGSVLYEIQEVVCKSLIPIKDSLKIEYPNDELYKVHLQSKDSQIPTPSYFKSIIYENDSFHSIVNIPEDLFKYISTLFYKDIIKRCPEININKINSHSVNEIISSFSKISKHERLFRFVFETIKENGILNSLEENDDAYFEFNELVIKSSRIISKLLFPLENDNDNEDLPQSLFQNGLMDKFYKCNNFKKKNQIISHVIKHSIKEIINNNIIIRILEFGGGTASLSVEVIGEIVTLLQENPNYQVEIEYTWSDISPAFIADAKNKINKIINDAAITNGLNVIYLPLTIGESLIETQSIKPSYYDFVIMSNVLHVVKDIKQVVEQMYQLLTPNGQLVFVEPPYKSILIDSIVGSFDQWWSFTDTDIRKDRCGMSQQSWYQLLKTCNFKDIVMSKECIFGSVIQAQKPPISLLNSQPKHDNIIIYGGGNNSRFFENIKLYSNSKSLIQIETIQEFNQFINKSTITNDSIIYFIKTLETLSLDNFAQITLEYIEINKKLLQINSLCKHVLIVSDSRKTNYLASSVVGAARYFDEFQQLKLHTLDFDYDSTQNYINSKNNKMVQFINILTDSKTNVHKEMIIINNKVYYEIVQKEKNLKLKYNSESFENQNNLMCSLSPNLEYQLQSKQIKLRDNQVEVKTIATGINYKDYLNFSGSNSNGDDNTGLPQFGYEFSGIITRVGNNVKDYKVGDNVFGLSNSCTSSHIVTNFKNIQLKPSKISHIEASSIPIDYLASFISLFNVGSLNIEDNESILIHLGSDGFGLSTFEILKWKGFKSNLFVTVNSDETKQYLLDRYGDFISGIYSNTDKSYVTEIKNELIKLGSKKKGVDLILNTLPSDFMDSNFELLTKNARIIDLTSNHLNQSEFLKNINFKYNHSYHNFQLSLFQKNKIQKCLNEISNAIENGELKTIPIKEFTNLNIKDAIKYITNGNIEKITVSHDHEIYSDIIYRYLDEKEFSILKSNYQINSNNLGKNILITGQSGIILEILKWIIKYSNINTIENVIILSRSSLKWELELLINQTKLSNNNIKFHFKSIDVGDSEQVDNAINEILNENQQITNIDSIYHFAFQQITCKVQEINMKHLDISHGAKSMGAINLHNQSIKRNWKLINFVMASSAISLIGSTDLCTYACANTLLDSFSKYRVSLGLPSACINFGSIESTGFVSKNESVSVFLDGGGFHPTPINQVLGLLDLQIQNSGKFTNSMLSNFKPSKFKNNQQISLFLKFDYLMNLKNNSEQTKKENIGNKNIDELFIEKVSELFSTDESKINKNLRLIDYGADSLIIVQLKNWIDKEIGINLITIQQLQNNTINISIKMILNSLMKNNQCGREI", "length": 2513 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "B0G101-1", "protein_name": "Probable polyketide synthase 8/35", "gene_name": "pks8", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNNLEIINLIDKGVAIVGVGFRIPSGNNENSICSPDDLFNNLKNGFDGVSSTSERWSDNFHKLGEISSPNAGLLPFNECKSFDPLFFGINPSDAHQIDPQQRLLLKCTWEALEDASIDPISIRGTNTSVFIGSSNIDYQHINKHQDSVLKNVIAQSAYAVSNRISYCFDFNGPSLSIDTACSSSLNAVSQGYHSILNGTSNMSIVGGVNLILDVGMIKAYSYLSMLSKTHGKCKAFDESGDGFTRGECATIVVLKNLQDAVKDGNRIYCVINGSSSNVDGGGHMDKVNLYSPSKQSQFNNINSAFKSTNGKLSINDIQYIEAHGTGTKTGDPIETEAISMAFKNRDKSTPILIGSIKSNIGHCEAGSGVASLIKCCLMFKYQCFLPNIHFKNPNPLIKFNEWNLKVVTSPIPFNKRINEKPVSMMINNFGVTGSNCCLLISEFKKQDYESYENNNNNKSNHKNILIPFSANSSNSLNQYQSKFKNIINNQFNFIDFTANQIYSKSNYLYQRSVVIASNSNELFEKILNKKQIQTKNSIISNMSFKGKNPITIFVFSGQGSQYPKMALELYNNDEIFKKSIDLIDSKLSKYYGYSVWGKLTTIKDDDLTSIHDPIFAQPALCMLSVSLFEIYCHWGVNPSFILGHSLGEISAAYCSGMIDLDTFCYTVYYRSIAQSKTNGCGRMLSINISDEEFKSMYSQKYPQIEIACYNSPQSIVVAGNESILNEISKELKEKEIFTAMLGSLSSFHTSSQQCTKDSILQLNIESNQPKVPIFSTVTTNLFNESNRFNSQYVYDNIIKPVKFTQTISNIYKHIESNQLNNDIVFIEIAPHPTISFYIKQMVPSSLNESVSVYSALHKKKNDVEEFQQTISNLYCQNGYSINFKCQLENKKSNQSINLPLYQWDDELYFAQTQTLEQYTKEGPPIDHLGLSNSYYSPFKNSYRTFIDINNKPFQYLKGHMVKGKYYFPGCGYIDIIIQLYKNQDIFISFIEFKTPLILIEGINQYLQTNIQQTGKSEYRAQFHFKDQKSNEWIQSSNANFQLLDHGNDIPSNYNIEEIIKNKCNLSKLTKNELYTQIKSKTGLNYTGVFQGATECYLGNDCSLSVLSLKSQTNSFLNIPILDTCLHGMLVLINDQSQIVFDKAIGFKYYSSNIPSDLKEYKDSIYVYSNLKPKNADSYHGSIIVMLSDGSVLYEIQEVIFKSLIPIKHSLKIEYPNDELYKVHLQSKDSQIPTPSSFKSIIYENDFFHSALNIPEDLFKYISTLFYKDIIKRCPEININKINSHSVNEIISSFSKISKNQRLFRFVFETIKENGILNSLEENDDAYFEFNELVIKSSKIISKLLFPLESDNDNEDLPQSLFQNGLMDKIYKCSYLRKKYQMISHVIIHSIKEIINNNIIIRILEFGGGTASLSVEVIGEIVALLQENPNYQVEIEYTWSDISPAFIADAKNKINKIINDAAITNGLNVIYRSLTIDESLLENQAIKPSYYDFVIMSNVLHVVKNIKQAVEQMYQLLTPNGQLLFIEPPYKSVLIDSIIGSFEQWWSFTDTDIRKDRCGMSQQSWYQLLKTCNFKDILMSKECIFVGSVIHAQKPPISLLNSQPKHDNIIIYGGGGNLSFVENIKLDSNSKSLIQIETIQEFNQLLSQSTITNDSIIYFIKTLETLSLDNYKQITLEYIEINQRLLQINSLCKHVLIVSDSRKTNYLASSVVGAARYFDEFQQLKLHTLDFDYDSTQNYINSKNNKMVQFINILVDSKTNVHKEMIIINNKVYYEIVQKEKNLKLKYNSESFENQNNLMCSLSPNLEYQLQSKQIKLRDNQVEVKTIATGINYKDYLNFSGSNNNNGDDNTGLPQFGYEFSGIITRVGNNVKDYKVGDNVFGLSNSCTSSHIVTNFKNIQLKPSNISHNEASSIPIDYLTSFMSLFNVGSLNIEDNESILIHLGSDSFGLSTFEILKWKGFKSNLFVTVDLDETKQYLLDRYGDFITGIYSNTDKSYVTEIKNELIKLGSKKKGVDLILNTLPSDFMDSNFELLTKSGRIIDLTSNHLNQSEFLKNINFKYNHGYHNFQLSLIQKNKIQKCLYEISHAIENGELKTIPIKEFTNLNIKDAIKYITNGNIEKITVSHDHEIYSDIIYRSLDEKEFSILKSNYQINSNNLGKNILITGQSGIILEILKWIIKYSNINTIENVIILSRSSLKWELELLINQTKLSNNNIKFHFKSVDVGDSEQVDNAINEILNENQQITNIDSIYHFAFQQITCKVQEINMKHLDISHGAKSMGAVNLHNQSIKRNWKLINFVMASSALSLIGSTDQCTYACANLLLDSFSKYRESLGLPSACINLGSIESTGFVSKNESISEFTDGIGYVPTPINLVLGLLDLQIQNAGKFTNSMLSNLISSKFKNIQQTSLFLKFDYLMNLNDNSEQTKKENIGNKNIDELFIEKVSELFSTDQSRINKNLRLIDYGADSLIIVQLKNWIDKEIGINLITIKQLQNNTINISIKMILNSLMKNNQI", "length": 2514 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "B0G110-1", "protein_name": "Acyl-coenzyme A oxidase", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MYKNRIEIIKKHLEVNNSQTTNNKDEVLEKELFNSIDTNINVGELKLLIDSVEESKYKDETREFIRNHPKFKENFIGLDMATYRQLVLEQCAAIANRGLIHFTDIKNNLHRYIGALEMFALYNNNILTKLSVQYTLFGGPIIFLGTSRHEKYIEDANTLKTMGCFAMTEIGHGSNVRGIETTAHYDKQTKEFIIHSPTPTSEKFWIGCAYLHATYAVVFANLIIDGTNYGIHAFIVPLRCPKSGAIMKGITIKDCGHKLGLNGIDNGQIRFDQVRIPRENLLNKYSDVSEDGVYKSQFNTPIKNFAATMSPFIVGRMAITKGCSGAAKTSLSIAIEFSHIRKQFGPSSNKELPLITLSSQQRRLMAPLARTILFDLYIQRLTNELCQEKLPASIHAHCSGIKAVYSWFCVAALQTCREACGGQGYRSANRIAEFKNDCDIICTYEGDNTVLMQQLAKYLLGVKQKQTNTTTNRIYLDGEDAKSLFFNFSNINQLFETREEMRLAELKQIIDNSKESAYFAFNNAIPWAVKLGFAHMTKIVFQNSINTLKLKNVKPLTHLIMLDALVSIEEDLGWFVSNHLISPNVAQSIPFLIQDLCFEVTKVSKQIIASFDIPENCKPSSKDLISDLF", "length": 629 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "B0G138-1", "protein_name": "Probable polyketide synthase 21", "gene_name": "pks21", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLENKEIAIVGIGFRIPQGKESINNGSVSHLWNNLKNGFSGIVETSERWSDNINLLGEVNNKFGGLLPLKEWSDFDPVHFAINPSEVPLMDPQTRLLLKCTWEALEDAFIDPIDIRGSNTSCFIGCSTLDYSTTNRDFNETSENYFASNVLHTISNRLSFSYDIRGPSMTIDTACSSSLNSIAMGFQSIQNGTSNLSIVGGVSLLLDPYISKSFSFLNMLSKKGKCKPFDSEADGYIRAESCGIVILKPLSDAIRDGNNIYCVINSFSSNVDGGGLNDKSNFYSPSKQSQSDNIKLALKSANMKASDISFVECHGTGTPTGDPIEVEGVSMALNSSKTSTPSKPLLIGSLKSNIGHSEAASGVASLIKCCLMFKNKHYAPNVNFDQPNPKINFKDWNIKVVTEAIPFTNNNEKPVSMVINNFGVTGSNCCLILSQFIEQSINQNGNGHSYPAESQQQQQQRFLIPFSANSVKSLKNYEDLIINDIKISTNSFKEFVKNQIYSKSKKLYQRSVLISSNWDQLKTKNKYFKTNNDKSSNITIKRNQPLVVIVFGGQGSQWNKMAQQLYECEPIFRSSMDKFNKELSKYYGYSVLDKLRSIKDDDIISIHQPIIAQPSILMLQISLFELYKHWGINVSFIVGHSLGEIATSYCSGMVDFQTVCKLIYHRSISQNNTNGCGKMLSVNISHSEFIELYSNKYPTIEVACYNSPTSIVIAGNENILKEISLNLKENNIFCAFLGSLSSFHTSSQHSTKNEILPLDIPSKQSRIPTFSTVTTNLFNHETTPFNSSYVYENIIQPVRFSQTISNLYQHIENNKLGNELIFIEVSPHPSLSFYLKQMIPKSSSYFNSVSVLTSTNKKNSNDLDEIHSTISQIYCLGYDVNFKCQFNHNDDDVSSIRNSKVNISLPNYQFDEQHYWKVDINFEQYRLNGPNVFNSLGKSMINYSSNNKSYESIIDINRNPFKYLKDHIVKGKYYFPGIGYADNIMKLYPNQDIIINNLEFLAPFVLKENVKHTLQTNVYQLGNTDYRVTFNIKDNKTNQWVQTCTGNFQLISLKDNNNDHSSKYDINQLLSECNFTTLSKQEVYKHSRSITGITHLGAFQGIEELYFGNDCIISKIQVNTENFDIDGKPVYQTYDKSFFNTALLDSCSQTIVGFITNSSQFVFERLEGLKVYSENIPTDKLKYKNIYCQAKFISLESDSYKSSVLVLLEDGTKLLEMDCISLHSTLPLLNSLLINNPTTELFTNNLQCKDSLVNILSIDNNQTFSSISSSNTVTEIIKQTIKPIINEKIVFRILQSFSDLELSKQIIETLNQIFDDNSLQEIDIEFTIIDNSNDKLPTLHDSSLIFKNDITQLKPSYYDIIINNNNDGDDETIIKSIFNILSSNGLLLIIGDDIGDKYNIDSLINLGFNENKIQKSNKVIQSQKSTILSNELTVVPNNKNDNIIIYCEKESKYTNEFMKLISNNHISCKQTIISNINEFNQLLPSITNDSIIYFIKSMEQLEMNNFKQITMEYIEINQQLLKHSLTCKHVLITIDSQIKNYLSSSIIGTARYFNEFPSLNLYSIDFDNQLSISSLLNKIINQLIENSNNHIQREYIIRNNSIYYEILKNEKNIKSNFNSNSFEDNDFMTLLDSTNLEYKLASKPKKLKKNQIEVKVLATGINYKDYLIYRGLVVIDENVSISKNPLGLEFSGIITRISNENQNCEFKVGDNVFGIACDTTASHVIADVLYVSHKPENISHVEAASLPVIFSTCLHGMFNIGNFNIDDDEVILIHSATGGIGLATLEILKWKGHKSPIFVTVGSKDKEQYLIDNYGSFITGIYSSRNKNYVNEIKSKLNQLYGTTGKFNGVDLIINTLPNEFTHSNFLCLKERGKIIDLSITHLNNNEFLNFNNFKFNKSYHNIELMHINKKVVSRLLKSISNALNENKLKPIPITTFQIEDVKEAIEYINQRKHIGKIVLDHSCSNGSIGSDGLLNQLIESDNNEKNHTILKYDFKIDTKNIIGKNIIITGQSGIILEILKWLIKYSPTESFENIIILSKSSLKWELELLINKTISRKDNNTKFHFKSVDVGDPIEMRKSINQILLENPNIDNIDSIFHYAFAQITKEVEEIDIESLDISHNAKTMGAINLHEISIEKSWKLKQFVMASSIASLFGSFNQCSYVSANLVLDSLSRYRKSIGLPSTCTNWGAIKSAGFVSRNELVSKMLDDQGFIPIPTNIILGSLDLQLQNSNKNSNLIVSKFNYDSIKKLSSETSTFQRLDFILNSIKEKDNDSNGGENSVSESIQTKILNKISELLSIEQSKINTDIRLSDYGADSLTSVQLKNFIDKDIKSNVITLQQLQNNTIDMNIQTILEQIKKLDSNETKGKSKNIIKKDSAPTLDYWRNEMKLDESIQAIKMNPIDFRNDSKVFLTGATGFLGVHLLSNLIKSPNCSVVYCLIRNKKSEPNPINAIINNLKHHKLYHFHNEFELSKIKVIVGNLASPLLGLSKLDFDYISNQINLIINSGADINLASNYEESKVVNIGGFIELIKLSTTGDYQKPIVGFSSVSVFFNASNCKEFDEETVIPTIENINNLPGGYMKSKVVVENLLREVAKRGIPSMLIRPPIIFSHEETGIGHDSDFFQLIIQSCYAVKKYPKIDKNILTSPIGWISLNTIKMIGNEKCWNKSSSNQLNIYSLNSEVSAMNPSFSFLEKQYGCEMVEYEQWKNIINQSKILSCVKLKTFHSLDDLYNIYNLGNGFGVSKKTKELLQSMNSYEGGMVNEKMIQNHINYIFKN", "length": 2779 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "B0G149-1", "protein_name": "Transmembrane protein 184F", "gene_name": "tmem184F", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLSHINIIYIIWILLFFFTCLISFFLVNRHLVNYSSPNVQKNVVRIVMFLPLNSGLSILSSIFPGIAIFNSLVRNCYMAFTAHCFFSMMTNSIGEKNMLDLFESQGKMKFLCCKVMKLNRKLFNTLRFGSIQFFIVKIFCSIATITCISISEEVHSILNVQSFAPYEFLISLVASIFCTISLSIFLAISKEKLSQYWPMTKYRIMIFIFFIEQFEYLFFALIFLRGPFFLGFKNSFDQTIFILHFTVVVTMFLFSIVYLFIYSYKNYRNKASNEPLVGRNFKDSFGLLNYLDVLNPKDLFIDFASIFKTNNNKFKELVEENGDKKPKKNIEDQNQENSNDQPLSIQMA", "length": 348 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "B0G188-1", "protein_name": "GATA zinc finger domain-containing protein 16", "gene_name": "gtaP", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNSYQIQNQPYQQIQNTHPSFQQVQPMQVPHLQQQQQHQTMIAQQQHTPPQQHTPPQMNMIQQHTQPMLSQPQISLQMQPPSPILASQQQQQHMQSSPILASSNLTNSNNASQTTLPIITSKLLLKKEPIDQEVVNSTHKTTTTNNKPPKQSKRKEKERLEEEKQTVAQQQQYQPPFIPLASNESNSDNPFKGSHAYGVSTTPYGNSQFNNNNNNNNNNNNNNNNSNNNSNNNNGNNNINNNNNNSNNNNNNNSNNNNNNSNNNNGNNNNNNNNNNNNNNNNHNTNNNNSNSNNNNNNGYQQDKKDDYSMMIWSEVGRKINILIRTTSKATKGTPISTQEIAEAIGASNGVTADLVELIKSINDPTYVRKLPPSSISNTPTMGSQSGGMVYNSSPMLSPSTMSPILQHGNYQMGGDMYFGGNNQFSGDKQSALNNVKNSKGGNTNNSGGGSSSGGTNDTQAKKPARRRKMRYGGTELSCHTCGVTNTPEWRRGPNGAKTLCNACGLAWAKSVKSEKQKELLANSTGVNITEPKKAQKRKKESSDNNNNNNNSSDSNKVLKSDDGSNNTNLTNDDDNGYPSSPNSSNSTSPSSHNINNNNNNNNNNNNNNNNNNNNNNNNNNNNIGNNNNNNINNNNTTNSITTPTTTPFPTTIPAMQIVSQLPVMVPQTQQQPHMSGNIISFQALHQNSGYQHYK", "length": 695 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "B0R191-1", "protein_name": "C-X-C motif chemokine 11-6", "gene_name": "cxcl11.6", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKTLAAFLLLSCLIAGEVNGQDRSSRARCFCVDKGLNMVLLKNLDKVEIFPPSPSCNKHEIVVTLKNGAGQKCLNPDSKFTKNVVLKAIGKRMQQSVPHSTTTGTVKSSMTSSTSAPTAFK", "length": 121 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "B1AV09-1", "protein_name": "Leucine zipper protein 4", "gene_name": "Luzp4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANHEDEIRQLRYLEAANSEEEYNEENDIQSESSRGQAFFPGHPRGRGHRRDSRGRNGHFFRQRFSANHPLLHLTRQVNLESLTRRNGNQSEERQLQQERIQLFFRSLHGLSQSHDHHIGRSHGHYSRRSRNRFRRAPVHSERSHVYSGRTNNYTDRPHHDLSDRPHNQLSVRPHPDLSGRPLHDYSGRPHQNHAVRLQHGHSDRYHLTHTERVLPNNSGIDHPGHTERDNQVQRGRAHDNQSGLAHHNHDGRSHHDHSGRAYHGHARRAHNNQSWRSDNNQSWRDLNQSWRGQNNQSQRGHDNQSQRGHDNQSRRGHDNQSQRGHDNQSQRGHNDQSWRAHNIRSRRDRYHTSLRSSSIQSWMLHERERYHGPRGRNGPRDASPPGSEPEIDRSSAIRERTDYLWVQEHRRNETVELNVGLEDGYSSAEESDESLDRLTCRSMLDTLY", "length": 449 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B1AY40-1", "protein_name": "SSX member B8", "gene_name": "Ssxb8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "METVSFCEKVPMEVLYEPKNICKAFQDISTYFSDEEWGKLTQWQKSAYVYMKRNYIRMTDLGVTVNQPVFMSGKEQDKQSLVEGIEVHDSEDECFEGSFGVTPIKQMKLTPVTISIHNVEGSLASGENNSNLAETSGIQVNVWSHRLRERKYRVIYEEISDPEEEEDDDY", "length": 170 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B1AYI3-1", "protein_name": "Predicted gene 13272", "gene_name": "Gm13287", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPVHLFLVGGVMLSCSPASSLDSGKSGSLHLERSETARFLAELRSVPGHQCLRDRTDFPCPWKEGTNITPMTLGETTSCYSQTLRQVLHLFDTEASRAAWHERALDQLLSSLWRELQVLKRPREQGQSCPLPFALAIRTYFRGFFRYLKAKAHSACSWEIVRVQLQVDLPAFPLSARRGPR", "length": 182 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B1AZM5-1", "protein_name": "Predicted gene 12886", "gene_name": "Gm12886", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLPCSLWLLSVCLLSWCCDAKLPVALDPESESVPKPPVLKTATEIAAIVVFMKTSNETPKSGTYGQSLQDGKNKIKDVEKEVLDACSQLCQSLAQDPNLHHGYILRAYFKEHQFLCCF", "length": 119 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B1B0R2-1", "protein_name": "Spindlin family, member 2D", "gene_name": "Spin2d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESSKLTKKRAGRKRQRSRSPALPKRNIVGCRISHKWKEGDEHITQWNGTVLDQVPVNPSLYLVKYDGIDSVHALELYKDKRVLSLKVISKRVVSSGVTDSSFADAIVGKEVNHLFEGEHGSKEEWRGMVLSQAPILDNSFYITYERDPILYTYQLLDDFKEGDLQIMEGFSDPPSLDIDLELVDGLIGKHVEYTNDDGSKRDGLIIYQIETKPRVYLVKYEDDVHIHVTHLEKEL", "length": 236 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B4F7F0-1", "protein_name": "Claudin", "gene_name": "Cldn6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASTGLQILGIVLTLLGWVNALVSCALPMWKVTAFIGNSIVVAQMVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVITLLIVLLGLLLYLAGAKCTTCVEDKNSKSRLVLISGVIFVISGVLTLIPICWTAHAIIQDFYNPLVADAQKRELGASLYLGWAASGLLLIGGGLLCCACSSGGTQGPSHYVARYSSPVPHSRGPSEYPSKNYV", "length": 219 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B7ZW38-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein C-like 3", "gene_name": "HNRNPCL3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASNVTNKMDPHSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIAGCSVHKGFAFVQYDKEKNARAAVAGEDGRMIASQVVDINLAAEPKVNRGNAGVKRSAAEMYGSSFDLDYNLQRDYYGGMYSFPARVPPPPPIALAVVPSKRQRISGNTSRRGKSGFNSKSGKRGSSKSGKLKGDDLQAIKQELTQIKQKVDSLLENLEKIEKEHCKQGVEVKNAKSEEEQTSSSSKKDKTHVKMESEGGADDSVEEGDLLCDDDNEDQGDNQLELIKDDEKGAEEGEDDRDRANGQDDS", "length": 293 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "B8JKF6-1", "protein_name": "BTB domain containing 35, family member 13", "gene_name": "Btbd35f13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRFLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGAINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYVLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "C0HKD1-1", "protein_name": "Spermatogenesis-associated protein 31F1B", "gene_name": "Spata31f1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSTMCFLWDTECPLYVYFCFFIIVLIVWQVRQNYQGLKCENRRSCCRRHQKVRQRAKDAASRARRLSREEDEKPCELLSIMKSQSWVPKQGNVRQLLCLDPSCQICEATTLEIRQLLQSKKSQISPALLGLPQRAACLEMPISSESFEWNQDFYSRYSTNSPVVPGNQTLTQLTEELTESTNADGVLLCWTDPLQIGQEFHLADMPMASETLVSPGLEEPVVLMNEEDTVHSNLNYIQQLQDHEALNSQIPFQTLTPQLTVTHPMAVSIVTDAPQPFLSPEVLRLLEIHVKKLMHFQRWGLPRRVEESLKQFMPNPPVYLPPEHNQPVSFILNTSSQDCVHRFEGISPETWYSYMDGQPIQTFWVSEWSSGDQGQRLSCKPIPSPVEKPLLTPDYELLHDLCLSPEGQVDGSQSNLQKKFTQLFCGLPSMHSESLGSTFLCTQGVSKNTLKPPYKEPHFLKVSPPIPLPEAAPPPSSTSPNESLDEPQRAQIGGVPFLTLSECKTLEWHLLQRQLQLQWGLPAVIARPPRVQSHTQYKHKPWNKAKPRETLKFFGPGKPFSALTRELFFIPQHARRLLEFHLQKRLIHLRWGLPQRIQRSINMLLSSTDLQSLPCGGSRLPNVSISQPGKPEAYGSGDTFLPTAGKGTTPMPHLFAKAQEMLKSHDTKCEQIREGKVPACVQSAWKGRIPGDLAAGTLFPNIPQGQPLELQAENNPDLHQEAVSWKPMDLDQEAQAFSGVFIEHCRRPQALSEETIKKLETTLRHKYLAFLSGLQALYCMAPTKATSPTVDQSVITTMPWSVKSPQKPLSQKSPLEALCLSGLEPCTQDDKETSANIAEEFQHGAQGHGRTEKVPPERQPLLNRPYSLDTEIMERVSFYLKRKALDIKLGISLKESVFQEPTATDLESESVQEPLGSPRESTLLQGPPTLCHVPVAPDPDKVCLKQPATAVQVVFQEQNQPSSRAVPHRSARQGSQVHRNMMEAQVHYVQMGTGGEMLNLGEPFSTESQSPGKSKSGYVPTVAGKRKIPGKPKVVGDLGEGDAGLGFSLVSLKTRQDGEQEKRLLHRQLQGSSLQAQTFHLEGACPHSPQESPELQFADPPPEVFMETDSEQDMEDSQSKESIVPEPARTAKAPQPMLSRASQGLPFPRSPTQRKPSQGQPGPGHVPPGHATPASPYTRPSRLPEAGLKNKMKLFFHSIKLKMKSKAHTEPSTVSTPGKVAKTSKENIDRGLPQAKSPTKKTKPEDFRGPKAQFSVVGPCLTPSYILDSKFWPRPRRVGSVSVLGHSYHCPRHCPRLAYANQQRNPP", "length": 1308 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "C0HKD2-1", "protein_name": "Spermatogenesis-associated protein 31F1C", "gene_name": "Spata31f1c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSTMCFLWDTECPLYVYFCFFIIVLIVWQVRQNYQGLKCENRRSCCRRHQKVRQRAKDAASRARRLSREEDEKPCELLSIMKSQSWVPKQGNVRQLLCLDPSCQICEATTLEIRQLLQSKKSQISPALLGLPQRAACLEMPISSESFEWNQDFYSRYSTNSPVVPGNQTLTQLTEELTESTNADGVLLCWTDPLQIGQEFHLADMPMASETLVSPGLEEPVVLMNEEDTVHSNLNYIQQLQDHEALNSQIPFQTLTPQLTVTHPMAVSIVTDAPQPFLSPEVLRLLEIHVKKLMHFQRWGLPRRVEESLKQFMPNPPVYLPPEHNQPVSFILNTSSQDCVHRFEGISPETWYSYMDGQPIQTFWVSEWSSGDQGQRLSCKPIPSPVEKPLLTPDYELLHDLCLSPEGQVDGSQSNLQKKFTQLFCGLPSMHSESLGSTFLCTQGVSKNTLKPPYKEPHFLKVSPPIPLPEAAPPPSSTSPNESLDEPQRAQIGGVPFLTLSECKTLEWHLLQRQLQLQWGLPAVIARPPRVQSHTQYKHKPWNKAKPRETLKFFGPGKPFSALTRELFFIPQHARRLLEFHLQKRLIHLRWGLPQRIQRSINMLLSSTDLQSLPCGGSRLPNVSISQPGKPEAYGSGDTFLPTAGKGTTPMPHLFAKAQEMLKSHDTKCEQIREGKVPACVQSAWKGRIPGDLAAGTLFPNIPQGQPLELQAENNPDLHQEAVSWKPMDLDQEAQAFSGVFIEHCRRPQALSEETIKKLETTLRHKYLAFLSGLQALYCMAPTKATSPTVDQSVITTMPWSVKSPQKPLSQKSPLEALCLSGLEPCTQDDKETSANIAEEFQHGAQGHGRTEKVPPERQPLLNRPYSLDTEIMERVSFYLKRKALDIKLGISLKESVFQEPTATDLESESVQEPLGSPRESTLLQGPPTLCHVPVAPDPDKVCLKQPATAVQVVFQEQNQPSSRAVPHRSARQGSQVHRNMMEAQVHYVQMGTGGEMLNLGEPFSTESQSPGKSKSGYVPTVAGKRKIPGKPKVVGDLGEGDAGLGFSLVSLKTRQDGEQEKRLLHRQLQGSSLQAQTFHLEGACPHSPQESPELQFADPPPEVFMETDSEQDMEDSQSKESIVPEPARTAKAPQPMLSRASQGLPFPRSPTQRKPSQGQPGPGHVPPGHATPASPYTRPSRLPEAGLKNKMKLFFHSIKLKMKSKAHTEPSTVSTPGKVAKTSKENIDRGLPQAKSPTKKTKPEDFRGPKAQFSVVGPCLTPSYILDSKFWPRPRRVGSVSVLGHSYHCPRHCPRLAYANQQRNPP", "length": 1308 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "C0HKD3-1", "protein_name": "Spermatogenesis-associated protein 31F1D", "gene_name": "Spata31f1d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSTMCFLWDTECPLYVYFCFFIIVLIVWQVRQNYQGLKCENRRSCCRRHQKVRQRAKDAASRARRLSREEDEKPCELLSIMKSQSWVPKQGNVRQLLCLDPSCQICEATTLEIRQLLQSKKSQISPALLGLPQRAACLEMPISSESFEWNQDFYSRYSTNSPVVPGNQTLTQLTEELTESTNADGVLLCWTDPLQIGQEFHLADMPMASETLVSPGLEEPVVLMNEEDTVHSNLNYIQQLQDHEALNSQIPFQTLTPQLTVTHPMAVSIVTDAPQPFLSPEVLRLLEIHVKKLMHFQRWGLPRRVEESLKQFMPNPPVYLPPEHNQPVSFILNTSSQDCVHRFEGISPETWYSYMDGQPIQTFWVSEWSSGDQGQRLSCKPIPSPVEKPLLTPDYELLHDLCLSPEGQVDGSQSNLQKKFTQLFCGLPSMHSESLGSTFLCTQGVSKNTLKPPYKEPHFLKVSPPIPLPEAAPPPSSTSPNESLDEPQRAQIGGVPFLTLSECKTLEWHLLQRQLQLQWGLPAVIARPPRVQSHTQYKHKPWNKAKPRETLKFFGPGKPFSALTRELFFIPQHARRLLEFHLQKRLIHLRWGLPQRIQRSINMLLSSTDLQSLPCGGSRLPNVSISQPGKPEAYGSGDTFLPTAGKGTTPMPHLFAKAQEMLKSHDTKCEQIREGKVPACVQSAWKGRIPGDLAAGTLFPNIPQGQPLELQAENNPDLHQEAVSWKPMDLDQEAQAFSGVFIEHCRRPQALSEETIKKLETTLRHKYLAFLSGLQALYCMAPTKATSPTVDQSVITTMPWSVKSPQKPLSQKSPLEALCLSGLEPCTQDDKETSANIAEEFQHGAQGHGRTEKVPPERQPLLNRPYSLDTEIMERVSFYLKRKALDIKLGISLKESVFQEPTATDLESESVQEPLGSPRESTLLQGPPTLCHVPVAPDPDKVCLKQPATAVQVVFQEQNQPSSRAVPHRSARQGSQVHRNMMEAQVHYVQMGTGGEMLNLGEPFSTESQSPGKSKSGYVPTVAGKRKIPGKPKVVGDLGEGDAGLGFSLVSLKTRQDGEQEKRLLHRQLQGSSLQAQTFHLEGACPHSPQESPELQFADPPPEVFMETDSEQDMEDSQSKESIVPEPARTAKAPQPMLSRASQGLPFPRSPTQRKPSQGQPGPGHVPPGHATPASPYTRPSRLPEAGLKNKMKLFFHSIKLKMKSKAHTEPSTVSTPGKVAKTSKENIDRGLPQAKSPTKKTKPEDFRGPKAQFSVVGPCLTPSYILDSKFWPRPRRVGSVSVLGHSYHCPRHCPRLAYANQQRNPP", "length": 1308 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "C0HLM6-1", "protein_name": "Small integral membrane protein 20", "gene_name": "Smim20", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAARNLRTALIFGGFISMVGAAFYPIYFRPLLRLEEYQKEQAVNRAGIVQEDVQPPGLKVWSDPFGRK", "length": 69 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "C7G009-1", "protein_name": "Thioredoxin fold domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNLILNGNWLVKFGAGWSGHCKKLQPVLENLAQHYNSDNENSKVKVAQVHCEEYESICIKYNIIGYPSLVFFDEGEIKHYRGPRLFENFKEAIDKHLNKEFVAFSQNQPSKIIVITNENLDLLLTGNWLVKFGAAWSLHCKKLQPVLENLAQHYNSDNENSKVKVAQVHCEEDNSICKKYNITGYPSLVFFNEGQIKHYTGPRQFENFKEAIDKHFKYGVKWSGHCKKFQPVLENLAQHYNSDIENSKIKVAQVHCEGDDSICKKYNITGYPSLVFFDEGETKPYRGLREFDKIKEATDKHFK", "length": 303 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "C7G010-1", "protein_name": "Calcineurin-like phosphoesterase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLKIKFSIISLFILKLVISKPILKFNNNNQFKIIQFTDLHYGSEPVDDIDTIFSQVNILDYEKPDLVILSGDMVTGYEEQFEDDDRNYWKYWNVFTRPFVERNIPWAITFGNHDGEGALSTNEILKIDQTFNLSLSQSNPVEMHGIANYVLKISSSNSLKSEPASLVYIFDSSTKGCSKLDWGCVHQDQVDWFKNTSKSFNKTDSIAFVHIPPVEIIDLWNNYPVYGNYSETSCCFDNDYGDFVSSLVESGDVHGLYFGHDHENDFHGDYKGVDLGYGRKSGAGSYSSKKPLGARVFQLTESPFTLSTWIREEDGNIVSQVIHPPSEFDRKPLQCKMKDKYSKKELIAIKVIGGFLIFLGIVVVGLIGFFGFKHYKKFKKQTLEMQNLV", "length": 390 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "C7G064-1", "protein_name": "SET domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKKDEKQFQQFPNKGRTVQANTDLPKGSTVFRCAPFASSIEDSDKLATEKYCGFCLQRIPKSDSKECLCKNCKLYSVCKSCRSINESAVEPFQIIIKSTFHLGSDTRDMRLLLRIIANIANGKQGMQTPIDDYQDFMGLTSTLDKVDKEHMTKFKRGVTSISSLISSVRGVGYLKNTITIHEILECFSSVLTNAHQFSYATSKEIGRGVCPTGYFNHSCMPNTTWSLDDQGMLLFSTSSNVKKGDELSLGYLANEYPLKNRRRELLDGYYFFCQCPLCEFQSNLSGYLCEKCKEPLLNDSIVYHEPSLTNPLDTGIGLIKHLRKMIDFRQQSVEFKKMFSSEQLSNILQKGVPKHIQSVFNCDASDNEELQQIVEISERSIKSLPLINGEPIDFYPLSDRNYYEYFKQLKNSKISSPEELQRIKDKILSLINPTIYNSFKDKIDKRLLI", "length": 449 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "C9JPN9-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein 12", "gene_name": "USP17L12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQLAPREKLPLSNRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKMLTLLTSAKVLILVLKRFSDVTGNKIAKNVQYPECLDMQPYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVRKVEGTLPPDVLVIHQSKYKCGMKNHHPEQQSSLLKLSSTTPTHQESMNTGTLASLRGRARRSKGKNKHSKRALLVCQ", "length": 530 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D3YTW8-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r258", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVRGKSLKTTEEVALQIILLCQFGVGTMANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTVFPNNMMAFAPRNPPTELKCKLKFFSHLVTRSTNLCSTCVLSIHQFVILVPISRGKLLLRASVPNLVSYSCYGCWFFSVLSNIHIPIKVTGPQITDNNTDSKSKFFCSTSGFTVRIVFLQFSHDATFMSIMVWTSVSMVLLLHRHRQQMQHILTPNQDARGQAESRATQTILIVVVTFVSFYLLNFICIIFHTFFIHYNLFIRLLGEILAAGFPTISPLLLIFRDPKNPCLELFHCFKPESLQNL", "length": 314 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3YTX5-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r259", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHGKSVKTTEEVALQLLLLCQFGVGTLANVFLFVHNFSPVLTGSKQRPRQVILSHMAMANALTLFLTIFPNNMIAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIHQFVTLVLVNRGKLILRASVPNFVSYSCYSCWFFSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVFLQFAYDATFMSIMVWTSVSMILLLHRHRQRMQHILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNFICIIFHTLLMHSHLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFNC", "length": 305 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3YTY1-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r107", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMSAFAPKTPPNELKCKLDFFSHMVARSKNLCSTCVLSIHQFVTLVPVNRGKGKLILRASVPNLWNYSCYSCWFYSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGMVFLQFSHDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 307 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3YTY2-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r138", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVHDKSVKTTEEVALQLLLLCQFGVGTVANVFLFVHNFSPVLTGYKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPNELKCKLESFSRLVARSTNLCSTCVLSIHQFVTLFPLSRGKGKLILRASVQNLASYSCYSCWFFSVLSNIHIPIRVTGPQITDNNTDSKSNLFCSTSGFIVGIVLQFAHDATFMSIMIWTSVSMILLLHRHCQRMQDILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNCICIIFHAFFIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 306 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3YXI8-1", "protein_name": "Predicted gene 10377", "gene_name": "Gm10376", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSQAGSFRKASPQTPNIDENEKRIKRLEKLKRDLQNIKNERDILQGILAKYKDLNDRTNFETFMLEMQNNQMMTDLKRMSQDISEALYKCQHLTKENQLYCCRNCHLLIESNLIQHKVRMLWKENRQLLRKQIALEECNIKTKILCKEGSQKIKDEYSRQAAGKQIIVVPGSKEEAVMSNPCA", "length": 184 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3YYI9-1", "protein_name": "Predicted gene 7347", "gene_name": "Gm7347", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRVNVDGRETREGRKDADLPSERNEGRRRWTWRMCMAHRQTTSPVPVKSKKQFEKEEKELIKKIQLTTKETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTFLHDLEMKNMEARENNQELKKEKNFYRNLHTRILLGENLIKKKLAILQQESKEIHADWAIIQQRLVELNLSGKDEQEKTSNLEAQENQVSEAARELGLATAEEDSILQNELPCQEAPAEHHPQHPSSSSDESSSDESSYSTCPEWE", "length": 267 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3YYY1-1", "protein_name": "Secretoglobin, family 2B, member 7", "gene_name": "Scgb2b7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGTLLLLGLLVTGELSFQTTEACFPFFEAYASVLSGSRVWLYQELQAFDATAEEKVALEKIQDCYSEESIRNILLEPKIMEAMVASPECLSYYGLDNIRSILDYISKLLGE", "length": 112 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3Z236-1", "protein_name": "Predicted gene 3676", "gene_name": "Gm3676", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSQTVSFRKASPQTPNIDENEKRIKRLEKLKRDLQNIKNERDILQGILAKYKDLNDRTNFETFMLEMQHNQMMTDLKRMSQDISEALYKCQHLTKENQLYCCRNCHLLIESNLIQHKVRMLWKENRQLLRKQIALEECNIKTKTLCKEGSQKIKDEYSRQAAGKQIIVVPGSKEEAAMSNPCA", "length": 184 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3Z8D1-1", "protein_name": "SIGLEC family like 1", "gene_name": "Siglecl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLWGLRSLLLLHLGFLSPVLVDTKKTAVEDGLCSTVPCVIEFSKAPLRKPMIVSYRLNENISFHAGTSQPRGPVADLSTEEVEYCILLTHNMLGRKNMTYSLYVGLGAQKDLTQKQELHIPGSSMAGEPVSLTCTIHSTCQESKALFLSWKGPIMSSSTTVPINPSSALAIDPKPEDQDTTLRCHLKLSLDNLSSSKVVKLQLVSPARLLNYSCLLKRTLTCSCSFHGIPTPSVQWWVGRTPVSVNSIDAILHMTSTTLESWTNSTIHLMWEPEIIKSLRCEGKNQYGVHASGIFLIPDKSSVSSVFLRGLIQGIVYGAIASALFFFFLVVLGMKILNWWEENQTCKNEEAPTLKKPVWGGAKPAEVGS", "length": 369 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3Z8T0-1", "protein_name": "High mobility group nucleosomal binding domain 2, pseudo 3", "gene_name": "AABR07053402.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKRKAERDAQGDEAKAKDEPQRRSARLSAKPAPSKPKKAPAKKREKIPKRKERKADAGKDANNPAENRDAKTGQAQKAEGAGVAK", "length": 86 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3Z9U8-1", "protein_name": "S100 calcium binding protein A7 like 2", "gene_name": "S100a7l2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQNLTSSEQEVMKLFDLFQNYHVRRTDKLDVQETKRVLREFFPNFMKALNASGIKILNDLEKEITLDEIWDMIGRMAMAYNKKNSNALKD", "length": 91 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZAM9-1", "protein_name": "Olfactory receptor", "gene_name": "Or4f60b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKKVNYSVTSEFVFLGFTNSWDIQLLLFLVSSMFYVACIMGNCLIIFTVASDTHLHSPMYFLLANLSFIDVGISSATSPKMISDLLKKHKVISFRGCVIQIFFNQAIGGAEMVLLIAMAFDRYVAICKPLHYLTMMSPQMCLFFLITAWVVGLMHSVIQLIFIVNLPLCGPNILDSFFCDLPQFIKLACMNTYRLELLVSISSGFMSLVSFFLLSISYIVIILTVLKHSSSGAYKALSTLSAHVTVVVLFFGPAIFFYIWPSSTHLDKFLVLFDAVVTPFLNPVIYTLRNKEMKRAMRRVFRHLMGYRQIS", "length": 311 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZC26-1", "protein_name": "Ferritin", "gene_name": "Fthl17fl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEASSQVRQNYDRCCEDAINNHIRLLLQASYSYLSMAFYFDRDDVALGNFKRFFLSKSHNCKASAEMFVFMQNKRGGHVFLPSIAKPDRESWHGGLRAMECAFRMEMTINQSLLNMHELAKGKDDAHLCDFLGQHCLDQQVHVLKKMGGYLTNLRQMGAPEQGLAEYLFDKLSLS", "length": 176 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZCM9-1", "protein_name": "Dynein axonemal assembly factor 3", "gene_name": "Dnaaf3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTTPAGSGNGFGTVSWWGLSPALDLQAESPPVDPDSQSKTEHKIPELDALLLGSVDGRHMLRTLARAMLWPLRRFNFYVLENNLEAVARHMLIFSLALEEPEKMGLQERSETFLELWGNALLRPSVAAFLRAQASHLSNLVPEPDRLEELLPWLSLRPLKFRERDALEAVFRFWSGGEKGPEVFPMSRLWDSRLRHYLGSRYDARRGVADWDLRMKLHDRGAQVIHFHEFRRWRDTGVAFELRDLSAYHVPNRTMASGRLLSHRGERVAARGYWGDIATGPFVAFGIEADDKSLLRTSNGQPVKTASEITQHNVTELFRDVAAWRGPRAIKGNVEETKSPEPDAPAQEPFTIHFLPLDSSQTLHHKTCYRGRFQLLYVSCGMIHLLSPELGACVAPGGNLVVELARYLVDLRPKELKAFSDRVVEIAQAAGFAPHTGTKPSETFARFYKLGDSTRGGGDSAVESGPVPSKVLAPTPESINPPQADQAPSLEVMSPPKVDQTPPLEAMSPPEADQAPPLEAMSPPRADQIPPLEAMSPLQAEVVLPLEAISPPQADLAPPPEVISPVQEALAMSSAIAPLKHVT", "length": 583 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZCW3-1", "protein_name": "SPATA31 subfamily E, member 1", "gene_name": "Spata31e1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "METFLLLMNSISDFWMSSSSMSTVMDMIFAILCGVGFFFLLIPFLKEYPGSPPPGSKKNISEVVKRRQSKDRKKSVTVDGCRDSQKNSLDIQHDLQTMESPIQHLLLDSSPHPFWNSKEKLNQLSLPQLFSYLKVLEALIQQKFNQLLLGLSSVLSESVVATAWVSREPSSGERKTVRFSDSLGFDQALPLAKGPPQRCLDQPLPHQLVTPSLVGMTEIQEQENLPNSISYQTPSIFQSRARGTAYPTTATGIQVPLPTTNEPCHPGLNWKDIPSCKVQNCQGASSQPTESLARCTLPTKNTRSASIPPEHYLMVHHHEQPQHEEKAINLGEQQRTHARFLPSKEPAQLQGDSPPNSNGYGKNWPELNQPAQPSTLNSKTYKWNQMMGPVPTGMLLKKVIAKYGIPNTIKKDLKLRVKDLLCTSSSTPGESLETKNLTLRTDEHSMNTTENLSFLDPKTTMMKSNIMQLPMKHRQLPCDSKAEPYTKAAFILENLHHQDPGGIRVETASSARLRSPLFEQSPPEVQKTQSSPPPIDSHGHSRSHPDQWQRYQSVQPHALCSQAQPQQSRSIQGTGRSILQPNISVWMSKHERWMRSEDVASGHTSWSSRTVGYRDRVSPSVAKQTNILKIKEESPHVWRANLGSGEITNEQALNNSNEDFEPIEAKRSQGHLQMPTQQNTGYLHLKTEEYSNNDLKVNKQPQAWSVSHHADGSNTVHHAMVKLPSQHSLPSLQNGWQDPKTSQGLGDLLMNRDQSVETQFRVHKDKTEATNDSVFHPSEKRPSNLKYGGISQGERLGRVKSSISSFTQLKDSAKTESKSSPNIGGKREAPSKSSLKFIWNGAQYENLSTKLKGQRDSLKKDIPPPVTEQTQEVVHRINVIYSTAVELQSLMDSLVHKLVKTVGEPSELTRKHMTKVQEYKMESLPFQLGSSSQPSKGLHDPNKSRSVRRMSDDHTSPKEPNNHTFTYRGNRDKMQAGVDVQRVCYQHLDKVKIGFGQHSTPMRNGNPCFHKKAGDKQESSLADQSTGDADQTKPKNEIVGSPHRIPERHNQSSRYREIRDNQEPSVDHKAIDPHQNTKKGMGYSQLMSPKENHPVKISGTAAQGASDPEEIRTKSGKECSPHRSPKMHDHSLRHREVRDKPQPGINTQRAYDQHLNSPKKRMTSENLLTPKGTNHPCWHRVTGDKQQSSLSDQRACDPEQMRRSGMSSYPQRSPKVYHLSCSSEKIGEKLLPLVNDQRTHDKHPNSVKTRGCDNLPTPKGSNHPQGYRVIEDKQQLGLAYRRTCDPGQIKKSGMGKGPCKDTEECNLLYRYKIIGNKQQPGIVHRACDRHQSSKEGMGQGQPMNPKVCHSAKHRRTGGQDQSGVAAQGASNPR", "length": 1373 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZDD6-1", "protein_name": "Synaptonemal complex central element protein 3", "gene_name": "Syce3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADSDPGERSYDNMLKMLSDLNKDLERLLEEMEKISVQATWMAYDMVVMRTNPTLAESMRRLEDAFLNCKEEMEKNWQELLTETKRKQ", "length": 88 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZDJ1-1", "protein_name": "Olfactory receptor", "gene_name": "Or13c3f", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDDMDKNNQTFVSEFLLLGLSGYPKTEILYFVIVLVMYLVILTGNGVLIIASIFDSHLHTPMYFFLGNLSFLDICYTTSSVPSTLVSLISKKRNISFSGCTVQMFVGFAMGSTECLLLGMMAFDRYVAICNPLRYSVIMSKEVYVSMASASWFSGGINSVVQTSLAMRLPFCGNNVINHFTCEVLAVLKLACADISLNIVTMVISNMAFLVLPLLLIFFSYVFILYTILRMNSASGRRKAFSTCSAHLTVVVIFYGTIFSMYAKPKSQDLTGKDKFQTSDKIISLFYGVVTPMLNPIIYSLRNKDVKAAVKYILKQKYIP", "length": 320 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZDT4-1", "protein_name": "Transmembrane protein 92-like", "gene_name": "LOC100364194", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQEAWVLDALTVIFGLLFSLQGVSSNKTIYKCEDIHCPKGFRCCDNECCLERKIWNTDNEPFRILFIILLVMLPLLCICGLVRRFCPKCRELQHEVRTADHQSPPDPPSIAPLESIWVTSLDPPPPYSQVVQKSTPTEPPPPYSLRPEDSTCPMRETSHETL", "length": 162 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZFJ9-1", "protein_name": "Family with sequence similarity 24 member B", "gene_name": "Fam24b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFSSFDLRTIIMIVIGSGILAAMFLLTGVVLCLYSKIARALNPSGTGKELDDQLCSDPCKTTQDQIIRVNSLNADTCRPFHGSTIGLENCQPLQCFSACGTYEGANSLTPCLCNTKEGL", "length": 119 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZFW5-1", "protein_name": "Transmembrane protein 107", "gene_name": "Tmem107", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRISGLVPSRFLTLLAHLVIVITLFWSRESNIQACLPLKFTPEEYEKQDNQLVAALCLTLGLFAVELAGFLSGVSMFNSTQSLLSIAAHCSASVALSFFIFERWECTTYWYIFAFCSAFPAVTETALFIAVFGLKKKPF", "length": 140 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZG05-1", "protein_name": "40S ribosomal protein S12", "gene_name": "LOC120100003", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEEGIAAGGVMDINTALQEVPKTALIHDGLARGICEAAKALDKRQGHLCVLASNYDEPMYVKLVAALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVVVKDYGKESQAKDVIEEYFEYKK", "length": 132 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZGM7-1", "protein_name": "Peptidase inhibitor 16", "gene_name": "Pi16", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRNCRVSWMPQHSSAAVSGICPPQEGPWSSYSLWPEPPLLREKEAVAKDSRGVDSTLVQTQGTQPSWRHCVSWAGPPDTAPAAPPQPGWCLCGKDFKSSRQTPDRERQRGLATMHSSCSPWVMLPQLPLLLLLLLLLLTATGPATALTEDEKQTMVELHNHYRAQVSPPASDMLQMRWDDELAAFAKAYAQKCVWGHNKERGRRGENLFAITDEGMDVPLAVGNWHEEHEYYNLSTATCDPGQMCGHYTQVVWSKTERIGCGSHFCETLQGVEEANIHLLVCNYEPPGNVKGRKPYQEGTPCSQCPLGYSCVNSLCEPERKPEKAQDSPPRVTEVPGSRETGIPSLATSESLHFSSVTKVSDSLATEPSPAVETKAPPSLATEGPSSMATEAQSFLTEVPSVSATHIQPSLDEGPVNFLTSTHIPVPKSTDKEASSKSRAASVSPEKSLYPKMSPTETGESPPQIQEEAEPKAELPEREDELPEAEVELPEAEAELPEAKAELPVSSEALVPVLPAQERGGPKASLEHSSYPVPTYLPNFPSASGNATGGRTLALQSSRTGAEDPEKASWDSKNSAPVWGPFPGLLLPLLLLAGIF", "length": 596 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZGX2-1", "protein_name": "C-type lectin domain family 2, member M", "gene_name": "Clec2m", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQTESSLRLSQSSHHRLTFDLKKVVTLWILVIGVIAVLLWGFFSFPKKFTVTRQTKNEVCSDGVKICLHGWNKLNRNCFTHFSHANSWFTAKETCKFHDATLAVFNDQTELDIVMKQMEDIQTFWIGLYKKDFRGPWVWTNGSKYNNWYEVQDYGHCAFLHKSGIDSTNCNDLKEYICTQEGHCP", "length": 185 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZIZ8-1", "protein_name": "Ferritin", "gene_name": "RGD1560203", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEASSQVRQNYDRCCEEAVNTHIRLLLQASYSYLSMAFYFDRDDVALENFKRFFLSKSHDCKASVEMFVFMQNKRGGHVFLPSIAKPDRKSWQGGFRAMECAFRMEMTINQSLLNLHELAKGKGDAHLCNFLGQHCLDQQVHVLKKIGGYLTNLRQMGAPEQALAEYLFDKLSLS", "length": 176 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZKK4-1", "protein_name": "Zinc finger protein 869", "gene_name": "Zfp869", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDTPIVGLSSPDQGLVSFEDLVVHFTQDEWDLLEASQKSLYGDVMLETFRNLTAVGYEWEDEAIEDHCEEPEVNLRDIVSHSEYTHEYEHKEYEEKPPDANFLTSVEGCVETKTSSGPSVCEVCLKTFGLYHLTYNGHHNYDYKELRGSQTEENDCEGNSCDKTSGSLQKEDKIHTGKKLYVCQECGKAFRYPSALQLHERIHTGEKPYECKDCGKAFRGLSALHLHERIHTGEKPYECKQCGRAFTYLSALQLHERIHTEERPCECKQCGKTFRYSRALKLHERIHTGEKPYECKQCGKFFRSHRTLKLHKRIHTGEKPYECKECGKAFRWLTSLKLHEKIHTGEKPYECQECGKAFRCQASYHRHKITHGGETLYECKECGKSFIYPSLLQVHERTHTGEKPFECKLCGKAFRCQSSLRLHERTHTGEKPYECKHCGKAFSSYNYLRFHERSHTGEKPYECKECGKTFTHRSYLRSHERRHTGEKPYQCIQCGRSFSRHSSFKRHQSVHGESPYEQYLIPLSPFSSKE", "length": 530 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZKM3-1", "protein_name": "Protein GPR15LG", "gene_name": "Gpr15lg", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRLLTLSGLFFMLFLCLCVLSSEGRKRPAKFPKLRPCCHLSPRSKPITWKGNHTRPCRPCRKLESNSWVVPGALPQI", "length": 77 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZL22-1", "protein_name": "Olfactory receptor", "gene_name": "Or1x2b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSKWGENETGVIEFLLLGITNDPQQQRILFWAFLCMYLVTVAGNTLIFLAISSDPHLHTPMYFFLANLSFDDVCFTTNIIPRLLAGHVSGTETISYAYCLTQMYFLISFGNVDTFLLAAMALDRFVAICYPLQYHTIITPRLCVGLASVVWISSGLIALVHTLLMSRLTFCSSIPEISHFYCDAYLLMKLACSDTRINQLVFLGAVVFFVAPCILIVFSYVRIAMAVFQIPSAKGRHKAFSTCSSHLTVVILFYGTVLGIYIRPPDSFSTQDTVATIMFTVVTPMLNPFIYSLRNKDMKETVTRLLHRGSKSS", "length": 313 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZLG9-1", "protein_name": "N-terminal Ras-GEF domain-containing protein", "gene_name": "AABR07047293.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFSCCVWTTEGSGLKKDKNEGQGGTWKFMLLSCLQCLWPFAQKEIDLTRDNQAQDHEDQGEHEYAPQVVTEPCRESRISADMVENLVNRLVSSLQGGDPFFIPAFLYGYRQFTTTQHVLDRLLKRFAYFYLGCEEDEQIKSSLCCFLDTWIDQYPEEFSQTILKKLKTYLTVNMPSSDLNLRVHMLLKELRQESNESEGKDDDSVSLPVTLLYKTASAADLSSSVEVGSHTSGDLDIEVWFPSQKVQPEPAYPHETETPQSTIKVISWD", "length": 269 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZMT2-1", "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3", "gene_name": "Ndufa3-ps1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGRSSDFFKNAQAKEPVLVVSFSVWGLAVILPMISPYIKYAGVISKATPYNCPVPVRDNGNVPGVPSQPQERLSPSLERLKNL", "length": 84 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZNA3-1", "protein_name": "60S ribosomal protein L7a", "gene_name": "AABR07049918.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKGKKAKGKKVAPAPAVVKKQETKNVVNPLFEKRSKNFGIGQDIQPKRDLTRFVKWPHYIRLQWQRAILYKQVKVPPAINQFLQALVRQTVTQLLKLAHKYRPETKQEKKQRLLAHAEKKAAGKGDVPTERPPVLRAGVNTVTTLVENKKAQLVVTAHDVDPIELVVFLPALCRKMGVPYCIIRGKARLGRLVHRKTCTTVAFTQVNSKDKGALAKLVEAIRTNYDDRYDEIRCHWGGNVLGPKSVARIAKLEKVKAKEFATKLG", "length": 266 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZNR1-1", "protein_name": "Elongin-B", "gene_name": "Elobl9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVFLMIRRKKTTIFIEAQELTTVLELKRIVQGILKRPPEEQLLFKDDQLLDESKTLRDCGFTSRVAKAQDPATVGLVFREDASEGLQIHPYSTPLLPSVMKTGTDSLE", "length": 109 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZNU6-1", "protein_name": "Olfactory receptor", "gene_name": "Or5p66b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSWLENGNHTTVAEFLLLGLTDDPVLRVILFTIILCIYLVTVSGNLSTILLIRVSSQLHHPMYFFLSHLASVDIGYSSSVTPNMLVNFLVERNIISYLGCGIQLSLVAFFGAAECFLLAAMAYDRFMAICNPLLYSTKMSTQVCILLVVASYIGGFLNASFAMVSFCSFLFCGPNIINHFFCDFAPLIELSCSDVSVYVIATSFSAGSVTMITALVIAISYSYILITILKMHSTEGRQKAFSTCTSHLTAVTLFYGTVTFIYVMPKSSFSIDQNKIVSVFYLLVIPMLNPLIYSLRNNEIKSALKKQIWRKTVS", "length": 314 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZPU6-1", "protein_name": "Large ribosomal subunit protein eL21", "gene_name": "LOC134485591", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTNTKGKRRSTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKGMPHKCYHGKTGRVYNVTQHAEGIIVNKQVKGKILTKRINVRIEHIKHSKSRDSFLKRVKENDQKEKEAKEKGTWVPLKRQPAPPREAHFVRTNGKEPERLEPSPYGFMA", "length": 160 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZQ96-1", "protein_name": "Large ribosomal subunit protein eL21", "gene_name": "LOC102550668", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTNTKVKRRGTRYVFSRPFRKHGVVPLVTYMRLYKKGDIVDIKGMGAAQKGMTHKCYHGKTVRVYNVTQHAVGIIVNKQVKGKILAKRINVWIEHIKHSKSRDSFLKQVKENDQKKEEAKEKGTWVQLSLQPAPPREAHFVRTNGKEPELLEPVP", "length": 155 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZQD9-1", "protein_name": "Developmental pluripotency-associated protein 3-like", "gene_name": "LOC120096627", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDKSSEKVDPVVNPETQMNDGSQREDEEDSPDDSEILQPETLVKVMKKLTLNPSAKPPKYHRHQRVRLRIKSQPVGNRSERIMREVQSAFPKTRVRTLLSVLKDPIARMRRFVRIEQRQRQLEGNERRDEPFRCLCTFCHYQRWDPSENAKIGQNQKN", "length": 158 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZQT0-1", "protein_name": "Glyceraldehyde-3-phosphate dehydrogenase", "gene_name": "AABR07071101.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MILCIKPSSTTKYCLNQCYLISCINKPNLLDGVNGIPLDIVAINDPFIDLNYVVYMFQYDSTHGKFNGTVKAENGKLVINGKPTTIFQERDLANIKWGDADAKYVMESTGIFTTMEKAGAHLKGGTKMVIISAPLADAPILKYDNSLKIVSNASYTTNCLAPLTKVIHDNFGIVEGLMTTVHTITATQKIVDGPSGKLWRGGHGAAQNINPETTGVAKAVGKVIPELNGKLTGIAFHVLTPNVSVVDLTCHLKKPAKYDDIKKVVKQASKGPLKGILGYTEDQVVSCDFNSNSHSSTFDARTGIALNDNFVKLISWCDNEYGYSNRVVDLMAYMASKE", "length": 338 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZTK7-1", "protein_name": "Uncharacterized protein", "gene_name": "AABR07012426.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGDLEAKISGYTHISVQRFCYKWTISNFSFCMDGIRENITSPVFSLEGNEEVQWCLRIFPNGVDEESKDYLSVSLGLHSCPKSPVLAKVQFWIINAQGEKHQIKEIPNILSFSPKHQWGLRKFILREFLLSRRHGLLPEDQLILCCKVSVVGPSFSTPGHNMTPANKDPRQMLADDVGELWENSLFTDCSLVVAGQEFRAHKAILAARSPVFRAMFEHEMLESLTNRIEIHDIHLQVFKEMMAFIYTGKAPHLHSHSMATELLAAADMYDLQDLKVMCEDSLCRNLSVKTAVPTLMADLHSTELLKTRVMDFIILHASEVSETLEWKSMVESHPHLVEEAFGSLASMHYFFLEPSLKR", "length": 359 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZV50-1", "protein_name": "Small ribosomal subunit protein uS4", "gene_name": "Rps9l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLVARSWVCHKTYVTPRRPFEKSRLDQELKLIGEYGLRNKHEVWRVKFTLAKIRKAARELLTLDEKDPRRLFEGNALLRRLVRIVVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLRLAKSIHHAHVLIRQRHIRVRKQVVNIPSFIVCLDSHKHIDFSLRSPYGGGRPGRVKRKNAKKGQGGAGAGDDEKKEK", "length": 195 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZWL0-1", "protein_name": "Ribosomal protein L32 like 1", "gene_name": "Rpl32l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAALQPLVKLKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILKPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRVTNLNARLRSAENE", "length": 135 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4A176-1", "protein_name": "Golgi associated RAB2 interactor 5A", "gene_name": "Garin5a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPRLRTSARSPAPAVRMAISPSGPLGFTSPVTQPRREASPGVPTTQGRGVAMKGGRDLKPASGRADRPLAQAYAPCRPGRLQRHLLSGEFDQLRDFPIFESNFVQVTRFGEVANKVTMGVAASSPALELPDLLLLAGPDKENGHLQLLGLFPLQFVQLFVHDVSRQQLKVKFRTGRAFYLQLRAPPETRDCEFGRWVRLLYRLRFHSPTCAVPFTHEDTVPEESEDEDEVEEGQLQPPEVRAGPRAQGCWARKDGKGPVSCHRGQTRPAGLRTLGALIQPRSFQITKGPEIKPAQLRAREMDF", "length": 303 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4A9N2-1", "protein_name": "Olfactory receptor", "gene_name": "Or4a77d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGQNNSVSEFILLGLTEDPAGQKTLFVVFLLIYIGTMVGNLLIVWTVIASPSLDSPMYFFLAYLSLIDALYSSTILPKLLIDLLCDKKTISLTACLVQLFVEHLFGGVEIFLLVFMAYDRYVAICKPLYYLTIMNQRVCVCLVVVSWIGAFAHALVQVFSVYKLPFCGPNIIDHFACDMYPLLGLACTDTYFLGLTVVGNNGAISVVVFMLLLLSYGIILNSLKTHSQEGRRKALSTCSSHIMVIVLFFVPCIFMYVRPVSNFPLDKFITVFYTVFTPMLNPLIYTLRNLEIKKSMEKLCRKIFTSDRIRISSCYS", "length": 316 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4AAM5-1", "protein_name": "Preferentially expressed antigen in melanoma-like", "gene_name": "Pramel", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDVKTPNKLLELAIHSLLNEESAAIQALEEIPRELFVPLFIAAFEGGHKNVLSAMVKVWPYYCLHIGSLSIQEPQHELLKAMIENLPVYPAPSSSSRGPKLRILDLRQDTDCRITCPEVSTKTPSCFYSCAYSDRSITKIERQLCCVNAECKTLLPRPVELLVDLSLDGSLMEKEFLVLLMYKIEESLGSLHVCCRDLQIDKLCKCKCTLKFLDLKCIDQLSVDRGSLSDITSILCRMIHLESLSLSNVTFRSLSGKVFKIFLSHLQRMEHLKELSLSSFCLKNHLDRVLRILPPGLDFLYLPFCDLSYRDFKFMSQSPQVTHLKLLNLSNNPMYWGDFEPFHTVLINLSGTLQHLEINHCLISDSAMSALIPALIRCTRLRVLGFASNPISMPMLVNIMHNLTPMKELKYVIYPIPVHCYERWHFQGSLDRQKLAIVQLQLKAMLELAHREDMNWITYCE", "length": 461 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4AAN9-1", "protein_name": "Similar to human chromosome 6 open reading frame 52", "gene_name": "C17h6orf52", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVETQSPGKECAVLPLWVLTVTSCPLPSAIREQLRVHHSLRCHRDNHYELLHSFYWLSCYSRGSTLSGNGLGPLCVTENPELLAGPWAIPEETTDPAENQEEDFLRDPNLHLNIEESDKEFMAVREELYDSLMNRRWHCLDTVLSNVPDELPQCEVF", "length": 157 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4ABB6-1", "protein_name": "Olfactory receptor", "gene_name": "Or13a27c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "VNCIWHSKMVSPNQTVVTEFVLQGFSEHPSLRLFLTGCFMSLYTIALMGNIVIIALVTSSTGLHSPMYFFLCNLATMDIICTSSVLPKALVGLLSEENTISFKGCMTQLFFLVWSGSSELLLLTVMAYDRYVAICAPLHYSSRMSPQLCGALAMGVWSICAANASMHTGLMARLSFCGPKVITHFFCEIPPLLLLSCSPTYVNSIMTLIADAIYGGINFVLTLLSYGCIIASILRMRSAEGKRKAFSTCSSHLIVVAMYYSSVFFAYISPGSSYNPERSKFTSVLYSVLSPTLNPLIYTLRNKDVKLALGRILASFSH", "length": 318 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4ADX2-1", "protein_name": "Olfactory receptor family 4 subfamily A member 80", "gene_name": "Or4a80", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGQSKIVTEFVLLGFTQDPAGQKALFVMFSLMYIATMVGNLLIVGTVIVSPSLGSPMYFFLASLSLMDAVYSTAISPKLIVDLLREKKTISFRACISQLFIEHLFGGVDIVILVAMAYDCYVAICKPLHYLIIMNRRVCILFLVMAWAGGFAHALFQVLAVYNLPFCGPNIIDHFGCDIYPLLLLACTDTYLIGLTIIANGGAMCIVIFILLLLSYAIILRSLQNHSQEGRHKALSTCSSHITVFFLFFVPCILMYVRPVSSFPIDKSITVIYTVVTPVLNPLIYTLRNSEMKNSMEKLLQKILSPNRLRLLCCLYY", "length": 317 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4AEJ6-1", "protein_name": "Peroxisomal biogenesis factor 11 gamma", "gene_name": "Pex11g", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALLNGLASALESYRGRDRLVRGSVGPWRDRSDLEFGQDSEMRKTGQRGGPKGTDIGRLVSYMRTSYLSLPNCWPYKCVLALQIRTLGYGCQLIGGVLVEQCPSRSEVGRRLLVVSAQLSHCRTVLRLFDDLAMFVYTKQYGLGAEEEDVFIRWLSVLSNMADQLYYPCEHVAWAADAKVLQVDSARWWTLSTAFWSLSLLLGAVKSLWTMLKLRQKLRSPTGHFASQLPRSKWRAVEARIWSEALTLLSNLADLANAVHWLPPGVLWAGCFPPWLVGLMGTISSILSVYQAARAGKQAEVDSP", "length": 304 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D6R901-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein 21", "gene_name": "USP17L21", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQLAPREKLPLSNRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKMLTLLTSAKVLILVLKRFSDVTGNKIAKNVQYPECLDMQPYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVRKVEGTLPPDVLVIHQSKYKCGMKNHHPEQQSSLLNLSSSTPTHQESMNTGTLASLRGRARRSKGKNKHSKRALLVCQ", "length": 530 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "E0CXP6-1", "protein_name": "UMAP1-MVP12 associated (UMA) domain containing 1", "gene_name": "Umad1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFHFFRKPAESKKPSGPEPEADGFVLLGATANEVRCKTSEAEGSQALETGKEDTSSVTVSGPETENQTGQTLQNNSLTAELLSDVPFTLAPHVLAAQGTISDLPDHVLSYDVGDNLSRFWYDFTLENSVLCDL", "length": 133 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E0CZF1-1", "protein_name": "PRAME like 34", "gene_name": "Pramel34", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGQTPPTHTLLTHEALIMSSLEELPTVVFPALFKEAFAGRHTNLLKAMVAAWPFPCLPVGPLMKKPNLETLQALLDGIDMRLTREFHPRRAKLQVLDMRNMYHAFWNIRADANDSDCKSKTLDEKQLVKVLPRYARRQRLKVIVNLSISSHFNKSKAYFLNWAKQRIGSLYFCCIKMRIWDPPDQVIRDIFNVFDPEHITELELNTDWTLLQLAHFASYFGHMKNLQKVFLAPLHKNTSPIINITNATEAKCVHKIISQFSQFNCLQHIFMKHVHFLRDYMNQVLGCLMTPLETLSITQCLISQRDFDLFSCSQNLFKLKHLEIRGMILYALDLMPLRVLLEKVADTLEILDFQWCRMKDSQINALLPALSQCTQLNQINFYNNDFSMCTLKALFQHTANWSKMNVEQYPAPLQCYSELGHVSVERFVQLCQELMYTLRAIRQPKSISFATDNCQKCGKPCVYDQGPILCSCFQ", "length": 475 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E1B8K9-1", "protein_name": "40S ribosomal protein S6", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MKLNISFPATGCQKVIEVDDERKLRTFYEKRMATEVAADTLGEEWKGHVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKCKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPHRLGPKRASRIRKLFNLSKEDDVRQYVVRNSLNKDGKKPRTKAPKIQRLMTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK", "length": 249 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "E1BBD9-1", "protein_name": "RNA polymerase II subunit A C-terminal domain phosphatase SSU72", "gene_name": "LOC112445820", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MPFLPLRLAVVCSSNQNRSMEAHNILSKRGFSILSFGTGTNMKLPGPARDRPNVYDFRAMYDDVYKDLLRKDKERYMQNGVLRMLERNMEKEMPRPERFQECKDLFDLILTCEERVYDQVVEDMNSGEQETCQPVHVINVNILDTNKEATLGAFLICDLCQCVQLMGDMEDRIGELLQAFEEKSGRSFLHTVCFY", "length": 195 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "E1BLY1-1", "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIIRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLSSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF", "length": 130 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "E7F638-1", "protein_name": "Moesin b", "gene_name": "msnb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSINVRVTTMDAELEFAIQSSTTGKQLFDQVVKTIGLREIWYFGLQYQDSKGFSTWLKLNKRVTAQDVRKENPLLIKFRAKFYPEDVAEELIQEATQRLFFLQVKEAILNDDIYCPPETAVLLASYAVQMKHSDYNSEHHIPGYLCRDKLLPQRVLEQHKLTKEQWEQRIQVWHEQHKSMSREDAMIEYLKISQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYERSDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKSPDFVFYAPRLRINKRILALCMGNHDLYMRRRKPDTIEVQQMKAQAREEKNKRQQERALLENEKKRRENAEKETEKIARETMELMERLRQIEEQTKKAQEELEEQTKRALELERERKFAQEEAEKLEKDRRIAEDVKTALLQQSENQTKNKDNLATELAELTSKINLLEDAKKKKEDEARKWQRRAIMVEVDLEKTKEELKSKLIGVHIQATSQTENDHDENDESSAEASAELTSTGSFRDRSEEQRITETEKNEPLQKRLQALSSELADARDDSKKTANDLIHAENVRLGRDKYKTLRQIRQGNTKQRIDEFESM", "length": 577 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E7FA22-1", "protein_name": "Protein tyrosine phosphatase type IVA 3", "gene_name": "ptp4a3b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAWLNGLYPVEVCYNSMRFVITHNPTNQTLDTFIEDLKRYDAKTVVRVCESTYDKTPLEKHGITVMDWPFDDGAPPPTKIVDDWISLLKKSFSEDPGCCVAVHCVAGLGRAPVLVAVALIEGGMKYEEAIHLIRLKRHGAFNSKQLTYLEKYRSKKRLRFKDPFKHRSKCWLM", "length": 173 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E7FE27-1", "protein_name": "Beta-1,4-N-acetylgalactosaminyltransferase", "gene_name": "b4galnt4b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRMRFPLKKIRKQFKLLLLLVLLMFAIGFTYLHINQGKAIKLHFNYGKDMERQAEGIGSSPKKHLSSSINPFEHGDAADSQEDGWGGEELNESAQESRANAEMHTLLAQKFLGLPWKPEYKGQANLHVFEDWCGSSVSQLRKNLHFPLYPHTRTTVKKIAVAPKWKNYGLRVFGFIHPYKDGDFQFAIASDDNSELWLSSDESPLNARLLVYVGQHGSEWTAPGEFSKFRSQTSKPVRLMSSRRYYFEVLHKQDDRGSDHVEVGWRPFLPGQKFDVIDSAYISLYTDESSLKMNSVHHIPQTLASHSLALQIYHRTETHTADMLKPDPRDTFYKIPMIDQSRLENVLPSCVYSPTYVVKDFPIARYQGLQFVYLSYVYPNDFTRLTHMEKTNKCFYRESPVYLEKFGFYKYMKMDEEEDDQPVFFPKPDDFLEEEEGVDPEEAINSSNRPVKRSGPSYQTSRITAATASSKPDRLDGGSKSSVFQQEKQYVQFKEQERSKKRTKGERFYRHSQVVDDEMTEIRQVKGSTGVLESQSGSLNEQTGPSEENGDSQTLSLVQRGRSLAWVLPDPALQSESKLIETASPTVKERSPFKLPHLYVLANRILGNAGKPVVEKESNSNKIYITRPRPPVSRPKPPVEVFPGVFLYQSRKSKRLVDLSSKWRSLKTQAAASAPWANFPLMDHKTSTQSALLKQSHLSSPTEPGPHNKGDPTASISDPDSVPPSSSEKRDHPGLNSSSQPPEEEPTKISEMAEGLDVAPQSRGLEEGEMSEYSYEEAEVRPHLAEEAINWQRTFSVNPVDFELLRSDWNDLRCNVSGNLQLAENEVIDVISQFMERLNERNRGIYTLARIVNVEKRRDSARGNRYLVELLLMEGGKRLVRLSEYIYLLLHRSRFEEGIESREGTVPSSHRTPSKIPLPSGSSAQTHTTTPWSTSWAKPLLCQPIMLQWRHDVMVHFVVPVKNQARWVQQFISDMELLHRETKDENFSVIIVDFQSDDMDVEQALKESTVPRYEYLKREGNFERSSGLQMGVDTIEDSHSIVFLCDLHIHFPHNILESIRKHCVEGRLAFAPIVMRLDCGSSPLEPDGFWEVNGFGLFGIYKSDFDKIGGMNTEEFKDHWGGEDWELLDRVLQNGLEVERLRLRNFYHYFHSKRGMWNVPVKRASQG", "length": 1167 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E7FFR8-1", "protein_name": "Ubiquinol-cytochrome c reductase complex assembly factor 5", "gene_name": "uqcc5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLRKSQNLKYMLSLVPGKKRFGVYRFLPVFFCIGGVMEWIMINVRIGRETFYDVYRRKQSERAYQQKTEEGLIMLTDSQAK", "length": 81 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E9PUW9-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r143", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCQFGVGTVANVFLFFHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMSAFAPKTPPNELKCKLEFFSHMVARSKNLCSTCVLSIHQFVTLVPVNRGKGKLILRASVPNLWNYSCYSCWFYSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGMVFLQFSHDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 307 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PUZ0-1", "protein_name": "Apolipoprotein L 11b", "gene_name": "Apol11b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDWNEISEDIRKVECRTFEKVIDNATEDLITDLRSLITEDGAWNGFVEAVELSSEEGEALRDALKERLAQDPTDENDRPQREQQKERFLREFPQLKKKLEDHIRKLRDLADKFDQVHKDCTISNVVSTSASAASGVLALLGLVLSTVTAGASLALSASSVALGATSSVSSFTTTVVEDSMTLSYESEARNLIGASMNVLEEILSIMPKITCKFYNTVADLVKAFKTLKGQIQTIRRARSISRRGAQARNLTSTGRSSGQGVSQMTRGARIRAGVFTSVFLGWDVYDLVTKQRICMMGEKQSQVEHCGTWLASWRRTFRNLSRSTMLCSQTCLSDALP", "length": 337 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PV04-1", "protein_name": "Eukaryotic initiation factor 4A-III", "gene_name": "Eif4a3l1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATTTRMATSGSARKRLLKEDGMTKVEFETSEEVDATPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIMKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACVGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLTTRAIKMLVLDEADEMLNRGFKEQIYDVYRYLPPATQVVLVSATLPHEILEMTNKFMTHPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCITKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNLADLI", "length": 411 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PVP9-1", "protein_name": "Predicted gene 4884", "gene_name": "Gm4884", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSENLQSSPFFGTESTLHPSLPLLSNSKQPAGTVCNFSRVSTPDVSSAWLLPSASSTSLQPLMVVQMETSLGLPPSGQTYCQLQSPELCNTCVQVSQIRPPAVNGDKALTAPIHSPSQFLALPPAPSLEQPENKTMPEIKEGTKENQDTPVLTLEHPDLQQPLHCTDTESLRQKPDSDNAHLGCICMGPKELVGLENEIGSSFDFKDITRFGADIQLPQLLNTLTDIDQDQSCENWRVTSGLFDQVRENKHKSFELLEGAPQAKFQHWDLVEGEGAVGVAGASDRAIDNMAKHPEGKAPKGPPSKNRRARKQEQERPSGPENKSKKTQELKQSRNRVKAEKEPSIPKTKRKRNPPELSQNSFKKPRTNLAMHMLESVQVFHPLGKKSEKKTGISSFRGLRTFTSNKDSGPGSVTTTVLNMPCESQGPPKSPGKVQSAESSVGKDCLSPSQYELPPAGKVKLVPLPFPTLDKPQSRPASRKPLSLALRRPTAVYPVQHHSHSVQPTTLRPAQPPPASSSLIASAKPAPPISSSATGPNVTNPNQSSAVPQLATSRPVPYRASSHTSFQRELVSAARNKVPSPPRPVPYRASSNTSFQRELVSAARNKVPSPPKPQTQYLLHDFSRQPIPWKKVDILGPVVSQPITKEQRPEREAMKRRSQQERENAVKNPSTGKLQIFLQRERDMEISQYYGYAM", "length": 694 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PVW0-1", "protein_name": "Major urinary protein 8", "gene_name": "Mup8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMLLLLCVGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIRVLENSLVLKVHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNAMDLVPEHVLVLTRQIAASRPENEEWPEPPVLSGDFSPGLHHHPFLSIQHPQYKFCDLHSILSH", "length": 235 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PVZ7-1", "protein_name": "Olfactory receptor", "gene_name": "Or8b3b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKYFCLPRFSIISMLTGNGSFVTEFVLAGLTDRPELQLPLFYLFLIIYTVTVVGNLGLIILIGLNPHLYTPMYYFLFNLSFIDLCYSSVSSPKMLMNFVFEKNSISYEGCMTQLFFFLFFVISECYMLTSMAYDRYVAICNPLLYKVTMSPQVCSMLSFASYGMAFAGASAHTGCMLRLIFCNANVINFYLCDILPLLQLSCTSTYVNEVVVLIVVGINITVPSFTILISYVFILANILNIKSTQGRSKAFSTCSSHIMAISLFFGSGAFMYLNHSGSMNQGKISSVFYTNVVPMFNPLIYSLRNKDVKIALKKVMMRVHSRFIS", "length": 325 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PW18-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r257", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVHDKSVKTTEEVALQLLLLCQFGVGTVANVFLFVHNFSPVLTGYKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPNELKCKLESFSRLVARSTNLCSTCVLSIHQFVTLFPLSRGKGKLILRASVQNLASYSCYSCWFFSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVLQFAHDATFMSIMIWTSVSMILLLHRHCQRMQDILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNCICIIFHAFFIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 306 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PW59-1", "protein_name": "Olfactory receptor", "gene_name": "Or8b50", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALANGSFVTEFILLGLTDQPDLQMPLFLIFLIIYLITAFGNLTLIILIVLNSHLHTPMYFFLFNLSFIDLCYSSLITPKMLMNFVLEKNIISYMGCMTQFYFFGFFAISECYVLTAMAYDRYVAICNPLLYSVAMSPKMCSYFILGSYFMGFSGAMIHTGCVMRLTFCDGNTINHYFCDLLPLLQLSCTSTYVNEIELFIVTGKDIIVPTVIIFASYGFILSNILKIRSTSGRSKAFSTCSSHIIAVSMFFGSSAFMYLKPSSAVSMNEAKFSSIFYSIVVPMMNPLIYSLRNKDVKVGLKKTLSRMFSHNLISL", "length": 316 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PXC3-1", "protein_name": "Cytochrome P450, family 2, subfamily c, polypeptide 69", "gene_name": "Cyp2c69", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPFVVLVLCLSFMLLLSLWRQRSARRNLPPGPTPLPIIGNYHLIDMKDIGQCLTNFSKTYGPVFTLYFGSQPIVVLHGYEAIKEALIDHGEVFSGRGSFPFFDKVSKGKGIGFSHGNVWKATRVFTVNTLRNLAMGKRTIENKVQEEAQWLMKELKKTNGSPCDPQFIIGCAPCNVICSIVFQNRFDYKDKDFLSLIGKVNECTEILSSPGCQIFNAVPILIDYCPGRHNKFFKNHTWIKSYLLEKIKEHEESLDVTNPRDFIDYFLIQRRQDKGIEHMEYTIEHLATLVTDLVFGGTETLSSTMRFALLLLMKHTHITAKVQEEIDNVIGRHRSPCMQDRKHMPYTNAMVHEVQRYVDLGPTSLVHEVTCDTKFRNYFIPKGTQVMTSLSSVLHDSTEFPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGKRICVGESLARMELFLFLTTILQNFKLKPLVDPKDIDTTPKYSGFSKIPPKFQMCFIPVE", "length": 491 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9PXM9-1", "protein_name": "F-box and WD-40 domain protein 24", "gene_name": "Fbxw24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEIHLSSFPMMEIFSYLDAYSLLQVAQVNKNWNALASNDFLWRKLCQERWLFCDMVTLQLLGKETWKQFFVYRTWQEHVKSRAIPEDFTYKEIPLECGVRGYAGYISGCALTRNGQGKSVVCMVSSKNKISTWDISESVITWVSPVQPASIKLLTTLPDMHIAVTVDIQSTIKLWDCHNREALATNNLESPCKSLKAVISKDGPIVLAGDILGNLYIFRIPDLHLISTVNVFPCGFDKIDCSPQKKWVLLSQNHPCIYPKVFYMSSLLRTSEFSDPVSTVLEFSLCKRAFWTPRREDRITLMSRRGRPIVTRFETFDMKLEENGNKTIVKGDLVASFSLQDYNENPKWMGVSDKSVIVCSTGSSLLLFSMKGLHLQTFQYSPEMIVRLWVDPVHVIITCNDGSIDVYMWEERSLLLKMCYRLQNGRHLPPFGFIKNLLCDDVSIVQLMIDRQGPCFLMAYTLNICS", "length": 466 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q069-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r157", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCHFEVGTVANVFLFVHNFSPVLTGYKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSVHQFVTLVPVNRGKGKLILRASVPNFANYSCYSCWFFSVLSNIHIPIKVTGPQIIDNNTYDKSNLFCSTSGFIVGIVFLQISHDATFMSIMVWTSVSMVLLLLTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPNDPCSVLFKC", "length": 297 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q0V3-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r68", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGVAIIKENQTQSKMDFWNMGIKILFLSQTTTGILGNFSLIIYYVVNYIVHTLKPTDLILMHLMTSNALMVLSTGVLHTMAAFGLAHLLNDLGCRLILYIQRVGRSTSIGTICLLSIFQAITISHRVSCYKGQKIKSSKYIGYSISLLWVLHMFLNFILFVDIFIKRNRNNMTSDRDFKYYSIVERNEFSDSLYVALVVCPEIFSSVLITCSSGSMIGILYRHKQRVQHIRSFHVSSRNSPEWRATQNILVLVSTFLAFYTLSSVLQGCIALLNNPNWWLVNITRLTSLCFPTFAPCVLMSHYSFMPRFSLVWTWNKTS", "length": 319 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q1C7-1", "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 4A2", "gene_name": "Speer4a2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWMGETREGRKDADLPSKSNEGRRRWTWRMWMAHRQKTSPVPVTSKKQFEKEEKELIKKIQLTTEETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTFLHNLEMENMEARENKQELKKEKNFYRNLHTRILLEENLIKKKLAILQQESKEIHADWAIIHQRLVELNLSGKDEQEKTSNLETQEHQVSEAARELGLATAEEDSILQNELPCQEAPAEHHPQHPPSSSDESSSDESSYSTCPEWE", "length": 252 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q1N7-1", "protein_name": "Predicted gene 8126", "gene_name": "Gm8126", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLRRLFHRENGNQGETRPRQKESAIPSCKNRRMKSFWGRHMSAGKTSSQNCNITNHMKNRNKLDDMKFYIRKINAERLELFRILDIDMNTDLNYRMNIEFTIIKSQHEKTMLDMEKITQSINDTIEKYKEFIEDKDSYSFMHTYLLKECNQLKEKVRMLLNENRKLLVEQADQEASYGEENRFCHESSKNIHPKY", "length": 198 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q328-1", "protein_name": "RIKEN cDNA 5430401F13 gene", "gene_name": "5430401F13Rik", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASSRILLVLLSIALLALTSAQRVNEDDGSALQEEDALEIGDSNQQHDDIHERLNEIKNHFQDQISQHGKEAIKSKKGKNGPRSRRSSDDDNLEVQDHQSGNEQAGGGQGGRGRSELKGQNGKGSQKGKKGKGGQQEQKGKGGQQKQKGKGGQKTKRGKGGQRSQQDNVQEVYQE", "length": 175 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q346-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r160", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSLKTTEEVALQLLLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILIHMAVANALTLFLTIFPNNMSAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIHQFVTLVPVNRGKGKLILRASIPNLWNYSCYNCWFYSVLSNIHIPIKVTGPQITDNNTDSKSKLFCSTSGFIVGMVFLQFAYDATFMIIMVWTSVSMVLLLHRHRQRMQHILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNFICIIFHAFSIHSHLFIRLVSVVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 307 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q366-1", "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 4f2", "gene_name": "Speer4f2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTMCVRLRRLFQRANVDGRETREGSMDAGLPCERNEGRRRWTWRMWMAHRQTSSPVPVTSNQFEKEEEELMEEIQLISQEKNGLRDYLNLTLGSKITRLNQSYEELKLKQKELMTLQHDLEMATMEAREENEELKKEINFYSNLHSRALMENNLIKKKLMTLQQESKEVQAEWASIQQHLDVNLSGKDEQENNSILDTQEHQVSETARELGLATDQEDSILQDELPPQEAPAEELSPQEAPAEELPPQEAPAEQLPPQEGPAEELPPQESPAEHHLQHPQSFSDESSYITYPEWE", "length": 295 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q3G0-1", "protein_name": "Zinc finger and SCAN domain containing 4B", "gene_name": "Zscan4b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASQQAPAKDLQTNNLEFTPTDSSGVQWAEDISNSPSAQLNFSPSNNGCWATQELQSLWKMFNSWLQPEKQTKEQMISQLVLEQFLLTGHCKDKYALTEKWKASGSDMRRFMESLTDECLKPPVMVHVSMQGQEALFSENMPLKEVIKLLKQQQSATRPIPDNAQMPVDTTQDRLLATGQENSENECNTSCNATEVNVGESCSGNEKDSLLITQKEQNHEHEEGNVVCQFPRGARRASQDTSSHHVDFPSALTPADVPMEEQPMDLSRENISEDKNNCYNTSRNAATQVYSGDNIPRNKTDSLFINKRIYHPEPEVGDIPYGVPQDSTRASQGTSTCLQESLGECFSEKDPREVPGLQSRQEQPISDPVLGKNHEANLPCESHQKRFHRDAKLYKCEECSRMFKHARSLSSHQRTHLNKKSELLCITCQKIFKRVSDLRTHEIIHMSEKPFKCSTCEKSFSHKTNLKYHEMIHTGEMPYVCSLCSRRFRQSSTYHRHLRNYHRSD", "length": 505 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q4E0-1", "protein_name": "RIKEN cDNA 5031410I06 gene", "gene_name": "5031410I06Rik", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRVNVDGRETREGRKDADLPSERNEGRRRWTWRMCMAHRQTTSPVPVKSKKQFEKEEKELIKKIQLTTEETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTFLHDLEMKNMEARENNQELKKEKNFYRNLHTRILLGENLIKKKLAILQQESKEIHADWAIIQQRLVELNLSGKDEQEKTSNLEAQENQVSEAARELGLATAEEDSILQNELPCQEAPAEHHPQHPSSSSDESSSDESSYSTCPEWE", "length": 267 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q501-1", "protein_name": "Predicted gene 2237", "gene_name": "Gm2237", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLLRLFQKENVDEGETRPTEKEEGILSHEKGRRKWFWRRHRSARNTSTQNSKMTKKRSKINELEELKLDMRKISNDMEEMCGILNLYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLHENVRILLNENRRLLVEQAGHKCPVGKKRGSLRRPARTSVSQVPRNSSPAESRTWH", "length": 211 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q5G7-1", "protein_name": "Oogenesin-1", "gene_name": "Oog1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVICLHCPDQDDSLEEVTEECYSPPTLQNLAIQSLLRDEALAISALTDLPQSLFPVIFEEAFTDGYIGILKAMIPVWPFPYLSLGKQINNCNLETLKAMLEGLDILLAQKVQTSRCKLRVINWREDDLKIWAGSHEGEGLPDFRTEKQPIENSAGCEVKKELKVTTEVLRMKGRLDESTTYLLQWAQQRKDSIHLFCRKLLIEGLTKASVIEIFKTVHADCIQELILRCICIEELAFLNPYLKLMKSLFTLTLDHIIGTFSLGDSEKLDEETIFSLISQLPTLHCLQKLYVNDVPFIKGNLKEYLRCLKKPLETLCISNCDLSQSDLDCLPYCLNICELKHLHISDIYLCDLLLEPLGFLLERVGDTLKTLELDSCCIVDFQFSALLPALSQCSHLREVTFYDNDVSLPFLKQLLHHTALLSQLIYECYPAPLECYDDSGVILTHRLESFCPELLDILRAKRQLHSVSFQTTKCSKCGGCYIYDRHTQCCRFVELL", "length": 496 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q6D7-1", "protein_name": "RIKEN cDNA 1700024B05 gene", "gene_name": "1700024B05Rik", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESHDNPVSAGRTSSQNCNITNHMKNMNKLDDMKFYIRKINAELEELFRILDIDMNTDLNYRMNTEFTIIKSQHEKTMLDMEKMKQSISDSIDKYKEFIEDNDSYSIRHTHLLKECNQLKEKVRMLLNENRKLLVEQADQEASFGEEKSSVMRPARTYIPSAKQQQL", "length": 167 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q7M8-1", "protein_name": "Predicted gene 5796", "gene_name": "Gm5796", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLLRLFQKENGDEGETRPKKKEEGILSHEKGRRKSFWRRHRSARNTSTQNSKMTKKRSKRNELEELKLDMRKISNDMEEMCGILNLYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLNENVRILLNENRRLLVEQSGHKCPVGKKRGSLRRPARTSVSQVPRNSSVI", "length": 205 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q8A4-1", "protein_name": "F-box and WD-40 domain protein 28", "gene_name": "Fbxw28", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEIHLPSVPMMEILSYLDAYSLLQAAQVNKNWNELASSDVLWRKLCQKRWLYCYMFTLPLHGLETWKQFFFDKTWQEHAKTRAKPEDFTYKEFPVEFEFRAHPWYISRHGLTRNGQEKSAVCMTSMNRISTWDIHEGAMTWESPKQPSYIVWMTTLPEMQIAVTIDMQSTIKLWDCHNKEVLASKTGLFFGCKLLQSEFTKDGPIVLVGDACGNLYIFRIPDLHLISKVNVFPYSIDELYFSPQKKWVFLIGHRLNDLTKVFYMSSLLRPSEFSAPVSTVLKVPVIRKVFWTPRREDRITLMSLILPKNITKFDTFDMKLEGIGNKVTIQGYLTASFSLAEDEGRPDYFGVSDKDVIVCSTRFSLLLFDINGLRLQTFHYCPEEIWRLWVDPVHVIVTCDAGSLDIYAWEKRSLLLRKCYRLRNRNYQQMSGYIIKTLCDDMSIISVANNSPKPCCLMAYTLSVCS", "length": 466 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q8I6-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r55", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEMLALQILLLCQVVVGTVGNILLFVHNFSPILTDSRLRPIQVILINLAVANAFMLLLLTYSHDMIDLVPKNPPTDLKCKLAHFFHMVARGTNMCSTCVLSTYQFVTLVPGNWARVMFREISPKVVRYSCYSCWLFSVLNNAYIPMNVRGPKKSHNDSDSQGKRMCSISVVNVDMNYLQFSYDIIFIGIMVWTSVSMVIHLNRHHQRMHYIHNPNQSNRGHAETRAAHTILMLVVTFVSLYILNCICVLFHVSFVESRRWLRNVIEFLALSFPTISPLLLIFRDPRGPCSLYFNVGLEIHVTGKVITEEQ", "length": 310 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q8L6-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r132", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSVHQFVTLVPVNRGKGKLILRASVPNLWNYSCYSCWFFSVLSNIHIPIKVTGPQIIDNNTYDKSNLFCSTSGFIVGIVFLQISHDATFMSIMVWTSVSMVLLLLTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPNDPCSVLFKC", "length": 297 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q8T0-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSFKNVLYFQTGLGVLANTVLLFFYVFIILGHRPKPTDLISCQLSFVHIMVVLIGGDILLADIFESLNIGNDFKCKTTFYLFRVMRGLSICITCLLSVFQAVTISPNTSVLAKFKQKVKKYMTHVFLCIWFFNLSFSTNQIFYVGGFTNVSETNQMQVTKSCSLLPMNYIIRGLIFTISISRDVFLVGVMLTTSVYMVIFLFRHQRQCKHLHSFSHPRESPEKRATQTIMLLVSFFVVLYWMDFIISFTSEMLRMYDPVILTLQKFMMYAYPTITPLVQISSDNRIIIMLKNIQSKCHPSFSLKDFFFFI", "length": 311 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q8V7-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r173", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSALNKALKTTEEVALQIILLCQVGIAAVANILLLVHNLSPNFAGPQLRPKHVILAHITVGNLLIILLTGFPSNIIVFVPRNPLNDLNCKLEYFIRLVARSANMCTTCVLSTYQFIVLVPGKWSRMILRGNTSTFVHYSCNSCWIISVLNNVYIPIKISGPWNTDNDTDLNSKWVCSMSGFELVMVFLRFVHDTMFISIMVWTSVSMMLLLYRHHQSLKHIHRSNGSLGLQPEARAAYTILMLVVTFVCFYLLDCMCIFFHISFVHFRVWLRHVNEILAASFPTLSPLMLIFRGPKKISAKGINTENAFINSH", "length": 313 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9Q9N3-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r152", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMSAFASKTPPNELKCKLEFFSHMVARSKNLCSTCVLSIHQFVTLVPVNRGKGKLILRASVPNLWNYSCYSCWFYSVLSNIHIPIKVTGPQITDNNTDSKSNLFGSTSGFIVGMVFLQFSHDATFMTIMVWTSVSMVLLLHRHRQQMQHILTPNQDARGQAETRATHTILMLVVTFVRFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 307 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9QAN3-1", "protein_name": "Predicted gene 1979", "gene_name": "Gm1979", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRANVDGRETREGRKDADLPPESNEGRRRWTWRMWMAHRQKTSPVPVTSKKQFEKEEKELIKKIQLTTEETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTYLHELEMKNMEARENKQELKKEKNFYRNLHTRILLEENLIKKKLAILQQESKEIHADWAIIQQRLVELNLSGKDEQEKTSNLETQEHQVSEAARELGLATAEEDSILQNELPCQEAPAEHHPQHPPSSSDESSSDESSYSTCPEWE", "length": 267 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E9QD93-1", "protein_name": "Granzyme K", "gene_name": "gzma", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDICRNLIVFHFLVFTFFKVTVCSDVSIVGGKDVKKALSWMVSIQVNQNHKCGGILIHKEWVLTAAHCKEDSYSSVTVLIGSLSLSKGSQRIAIHNYEIPETFNKKTKKDDIMLIRLSKKVKAKPYKIPKKEKDVQPGTKCVVRGWGTTDYKGKQASDKLQMLEVLVVDRVQCNRYYNRNPVITKDMLCAGNTQQHRGTCLGDSGGPLECEKNLVGVLSGSHGCGDPKKPTVYTLLSKRHITWINKILKQQFNSTRF", "length": 257 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E9QLQ1-1", "protein_name": "Defensin, alpha, 35", "gene_name": "Defa35", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTFVLLSALVLLAFQVQADPIHKTDEETNTEEQPGEEDQAVSISFGGQEGSALHDELSKKLICYCRIRGCKRRERVFGTCRNLFLTFVFCCS", "length": 93 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1LPT0-1", "protein_name": "Gap junction protein", "gene_name": "Gjc3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCCSFLRQLLARESQHSTPVGRFLLPVLVGFRLLILVSSGPGVFGNDENEFMCHLGQPGCKTICYDVFRPLSPLRFWAFQVILMAVPSAIYVAFTLYHVIGYWEVPGRNKEQEAQICKGGRCKDVSGAMSLKLLWAYVAHLGVRLVLEGAALGVQYHLYGFKMPSTFICREDPCIGSTTCFQSHPSEKTILLNTMFGISGACLLFIFLELVLLGLGRVWKTYRHKLPLFKNLSTSERSVRHKDTTDDLSVVETKEPF", "length": 257 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1LT33-1", "protein_name": "Cytochrome P450", "gene_name": "Cyp2b14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELGVFLLLTFTVGFLLLLASQNRPKTHGHLPPGPRPLPFLGNLLQMNRRGLLRSFMQLQEKYGDVFTVHLGPRPVVILCGTDTIREALVDQAEAFSGRGTVAVLHPVVQGYGVIFANGERWKILRRFSLVTMRNFGMGKRSVEERIKEEAQCLVEELKKYKGALLNPTSIFQSIAANIICSIVFGERFDYKDHQFLRLLDLIYQTFSLMGSLSSQVFELFSGFLKYFPGVHKQISKNLQEILNYIDHSVEKHRATLDPNTPRDFIDTYLLHMEKEKSNHHTEFHHQNLVISVLSLFFAGTETTSTTLRYSFLIMLKYPHVAEKVQKEIDQVISSHRLPTLDDRIKMPYTDAVIHEIQRFADLAPIGLPHRVTKDTMFRGYLLPKNTEVYPILSSALHDPRYFDHPDTFNPEHFLDANGTLKKSEAFLPFSTGKRTCLGEGIARNELFIFFTALLQNFSLASPVAPEDIDLTPINSGAGKIPSPYQINFLSRCVG", "length": 495 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1LYQ4-1", "protein_name": "Alpha-1-B glycoprotein like 1", "gene_name": "A1bgl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDLLVLLEPLASLTLTCKVCEPSKDLHRILHLSSMETACTLSLALPPTLPSASLIFSASGVHTLILLRVRLNHSLILLSLIHTGPLPRPWLSANPVPWITPGLRTFLLCQGTVRDVVFMLRREGDDGNKEKEQGIFQVHEPGNYSCNYYTNTEYTPSKPSGTVTIKEYVIPPPPMLTSLESSTVDEPEMTQMSLLCVAPLSDVEFQLRQGEREMKVLIVSTSPERASFYLKLSDMGDHSPFTCRYRLNRMTAWSEDSKPVQLMWSDETLPEPVLTVEPSPHQSFEPGSTVQFRCTAPKAGLRSEAGLRFGLHLEDLYDHRLLQTQKSSGNETVFQLRNVSATDSASYSCIYTELTPPYSGSAPSDFVILRVNGPPPPPKLQALWTGKVFAGHDVVLRCQSDVTGVIVELLRDGKFVPYRILRVLNNYSDLGLHSVGPQHTGNYTCRYTSWLPEPVQSEPSNPVELLVEGMASGVVVVGFCLLIFPGLCILVNCAI", "length": 495 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1M6N1-1", "protein_name": "Zinc finger protein 945 like 1", "gene_name": "Zfp945l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTASLVNVSKCLLTFRDVAVEFSMEEWECLNYSQKTLYRDVMMENYNNLLFVENHCKYKKVLDQDPNSIVHNVNIYEKAYECNELVKMTHESSQGTPFKTKHKDASLQISTLNRQKIGNTRDEPCKFKDCINFLNVFVIRQNQRIYIGEKEPTTIEYENHYNSKHEVMLKQSNSTGNKPHIFRKYGQCFKIYSSFSRYQNDHTSEKFYKCIKCRKSFLHLSQLKVHYKIHYRKYPCKCTACSKCFYHTFGFKRHYSIHPEVNTYKSSDCDKSFIYYSSLRKHQKIFGGERHYECNEGLRSLYTVFQPVYYYIPHIGEKAYKCSECEKCFTRKYHLTVHQRIHTGEKPYKCGECDKCFTRKYHLTDHQRIHTGEKPYKCSECKKCFTRKYHLTDHQRIHTVEKPYKCSECGMSFMKKYHLRSHQSIHTGEKPYNCSECDKGFTYKGHLRRHQKIHTGEKPYKCSECAKCFTENSKLRRHQRIHTGENLYKCSECDRCFIENNKLRSHQKVHIGEKPYKYSEYDKCLTQKGSLRSHQLIHTGEKPY", "length": 544 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1M7A9-1", "protein_name": "Large ribosomal subunit protein uL6", "gene_name": "AABR07026048.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MANRLAHRPIQWRNFLSQDSLDQDTMRKKTILSNQTVDIPENVDITLKGRTAIVEGPRGTLRRDFNHINVELSLLGKKEKRLRVDKWWGNGKELATVRTICSHVQNVIKGVTLGFCYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVWMRTNVACSVSQAQKDELILEGNDIELVSNSAALIQQGTTVKNKDISKFLDGIYVSEKGTVQQADE", "length": 219 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1M9J5-1", "protein_name": "Uncharacterized protein", "gene_name": "Esp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "ITFLPVTLFLIILLWPSMITEGRVLTQNQKELSISADHNKNHKSDLDKIEFQGQPNIQKAVEMTICASDKDQTLLEDQANANQDKQLYKDSHLLCGRSLDHIVK", "length": 104 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QDL3-1", "protein_name": "Novel nacht domain containing protein", "gene_name": "LOC560232", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEDKHTPGDLDLSTGCSSVHQNRAEAEPSCVSMKSDVSMDPPTNFKSGNTGPAVSSRKRKRAEAEPSCVSMKSDASMDPPLKFKSKNTQPAVSVDRDDQSGDLLQDSLQPEHDELQRVKEQHKTTMKNKHERLFEGINHGETQTLLNRIYTQLYIIEGESEGVNEEHEVIQMEKRARTKPSQHTPVYCNDIFKASAGAGHEVKIKKEKAQIKTVLTKGIAGIGKTVSVQKFILDWAEGKANQDVDFMFVLPFRELNLIRDHQYSLHRLLLDFHPELEDLEPKIYEQCRVVFIFDGLDESRITLNFSDEEKVCAVTESSSVAVLMWSLLKGDLLPSALIWITSRPAAAHQIPSRYIKRLTEIQGFTEPQKEEYFRKRISDEHQASRIISHIRRARSLQIMCHIPVFCWISSTVLQKLLEEDVSAEIPQTLTEMYIHFLLIQINMRKQKYEERDPEKLLQSNRGVILKLAEVAFRQLMKGNVMFYEEDLIESGIDVTDALVYSGICTEIFKEESVIQQRKVYSFIHLSFQEFLAAFFVFYCHLTKKRELLELILGYSYDQYLQSSSEKSLYDLLSSAVDEAVRSSNGHLDLFLRFLLGVSLESNQRLFQDLLTHTEESSESIRRITQYIKDQIKSDDYFKRAAERFINLFLCLLEVKDQTLAREIQEFVKSDKHSEEELSPAHCSTISYMIEMSEEPLDEFELQKFNTSAEGRLRLTTAVRNCRRAL", "length": 725 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1QGM0-1", "protein_name": "Galectin", "gene_name": "lgals1l1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPTVLIQNMAFKVGQTLTLTGVPKPESPEFTIDIGNSSEDIALHINPRFDAHGDQCIIVCNTFQNDCWCEEHRDENFPFVQGEEFQIKITFTNEEFLVTLPDGSEINFPNRQGSEKYKYMNFTGQARIQGIEIK", "length": 134 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1QMQ9-1", "protein_name": "Uncharacterized protein LOC541480", "gene_name": "si:ch1073-398c20.1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADIKQESDDIRIAEVFTLKQEDPEEQTDLLPLRKEFQGLDNVKEEEALVEEHQDITPAEKRITCSETENTTQKASEKTGSRSSFTCEQCGRDFAKQGTLNNHMRIHTGEKSFTCQQCGKGFTQKRTLRNHIRFHIEAESLSCQQCGESFTQKQDLTDHMRVHTGEKSFVCDQCGKVFLRKDGLEKHLKNHHKEKPHVCPCGKSFTDKTKLEEHTKTHTGEKPHTCDKCDECFSGKYDLIRHMRFHSAETPYICQQCGKSFALKRVLMTHVKIHTRDRPFLCKQCGKCFYRKDNFNRHVRVHTGEKPYACSECGKSFSERFQFNEHSRTHSGVKRFSCEQCGRGFNRKTELKRHMRVHTGEKPYMCPQCGKTYAFKTGFDIHMLHHNAEMPYICPQCGERFSVKQRFDVHMKIHAGNSDK", "length": 420 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1R1Q6-1", "protein_name": "Uncharacterized protein LOC641576", "gene_name": "zgc:152710", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVLIWTQFGVKHKNVKCKVRVIHGEEGSWSSEEVREEPEVSSPPPSPECVDYYSVLGVSNDSNEEEIRKAYKRLALRYHPDKNSDADAEDKFKQIAQAYDVLTDPEKRNIYDQQGLTKGGVAPTCNKTDPSHNSKADAHSWHMFFNFDLDSDDDLFNPFTRNPLPHLSRHHGNKGGLKPAGDAEVHDLSVSLEDILMGVTKRVKLTRLRQTDKHTLKPEERVFDVEVKKGWKEGTRITFPNEGHQMLGHAPNDLAFVIKEKKHAHFRRDGSHIVYTCTITLREALCGCTVNVPTLDGQMKPLPCSDVIKPSSVRRLIGEGLPRAKNPAQRGDLLVEFQVVFPDRIPPSSKEIIKHSLGQC", "length": 360 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1RA39-5", "protein_name": "[F-actin]-monooxygenase mical2b", "gene_name": "mical2b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGETEEERTSQAGQLFENFIQATTCKGTLQAFSVLCRQLELNPSDHRGFYSSLKTAVTFWKAKGLWGKLDKRAGHKEYSKGRACADTRCLIIGGGPCGFRTAIELALLGAKVVVIEKRDTFSRNNVLHLWPYTIHDLRNLGAKKFYGKFCAGSIDHISIRQLQLMLLKIALIVGVEVHVNVEFVKLLEPPEDQSTDGQGWRAEIRPADNPVSDYEFDVIIGADGRRSTLDGFRRKEFRGKLAIAITANFVNRNTTAEAKVEEISGVAFIFNQKFFLELKEETGIDLENIVYYKDNTHYFVMTAKKQSLLDKGVIINDYIETERLLAFDNVNQEALLSYAREAADFGTNYQLPSLDYAINHYGQPDVAMFDFTCMYASENAALVREKSHRQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMIKGWAQGKEPLDLLSERESIYRLLPQTTAENISKNFEQYTIDPATRYPNLNSSCVRPHQVRHLFISGEQDLSSLERSGQTRRSVSISRRESEVRPGRLLLWCQNQTQDYRGVNVTDLNTSWRSGLALCALIHRQRPELIDFDSLNEADCAKNNQLAFDVAEREFGIQPVTTGKEMDAERGPDKLIMVLYLSKFYEMFHKSTQSVTGLPKEIDANNGDCSSKTANSLYNSINHARKRIPKLDKKLEESDVNRKRKKASSHHEELMSCQTAPPAGEREEQKENKVRSMATQLLARFEENAPSCALRRQSDSESDSDADRPVSLDLTENPRFARPKIEPTHPSTTPDKAKWQPSPYLRLLESNTRSETLHTEHYVESQSSHRLTEIQSECQYSSVSSAYKSSERRPRSPLIPFTPTLSPMMHCLQQLEEQVIQQRKREPLNRKSIKERAQKLSSLFTGNPAQPQTDESSPAVSPSSPPQTIPESSTLSCLLSPAPSLTHKQCSEASETHLKADKHTEIRRVERLDPSKQRTVGKVSSAIGVKAATLAILYETDHRPNNPITLSLTEARRCAESGLVSVRKEFSASLGGSDTCVFCQKRVYIMERLSAEGFFFHRECFRCHICGCSLRLGAHTFDSQQGTFYCKMHFSQRKTSTRHRRGEIQDGGIRSSSITISNHTSTDGTRGQPSGGEFDSSTQQDLQTLPDSKEIISVSEVKDSSKKADPADSAPACPDSPLQKVKRSTAKGEITNKNILWKKKIRSTLPLVLMKKFHRGKPEDKTEVLAEEDGNSDFEEIHESLSSKKPSNPSTDSNCLPTKDNSSTPLDEIPKIPLYRTHVLPEYPKPSSSSPEPIVTSISSDPISFSPKKKLTLSLSEKEKLLNWDLTNPGKSGAEEQQQQHVKPSISLQHDHPEPTHPQPEPAPPLFGFQQWANNLRKSFSKGSNPVVLRRNRPMKARPLSEGSFNVGAVFQDEERCGSLVDEGEARPRTESEIASLLEQVALGSKTSRGTKDDMASLPPRKLNFFSSLRIKRVEGAEQSRGEGQKDILSILSRFRNKASAQQQQQQKSNSSSEDEQEPKLTHSGALQKKKEKIAIRQTKSDELKRLHRAQVIQRQLEEVEEKQRSLEEKGVALEKVLRGENGDDGSTDEAALLQTWFKLVLEKNKLSRYESELMIFAQELELEDTQSRLQQDLRRRMATEDCEKSASELVEEQNILVEIMKVVEKRDKLVSLLEEQRLKEKAEDRDLESLILSRGYQFHWT", "length": 1679 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1RXL1-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100152495", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFTICNDSHSDFILLGFSDKPYLEKILFWVVLIFYCLTIIGNLVIILVSLKDPKLHIPMYYFLSNLSLLDLCFTSSCVPQMLVNFGGPEKTISYIGCAIQLYVFLWLGATECVLLVVMAVDRYVAVCHPLQYTTIMHPKLCLELAILAWGTGLIQSLTQSPATLQLPFCSNRRLYDIVCEVPALIQVSSADTIYNEIQMSIASIILLVVPLVIILSSYGAITKALLRVKSTEGQKKAFGTCTSHLLVVFLFYGTVTAVYLQPKSHYAHEQGKFLTLFYTVITPTLNPLIYTLRNKEVKGALIRLGKKTWDDLCWTIA", "length": 317 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1RYD0-1", "protein_name": "Transcription elongation factor A like 3", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRQVKHLRSGSLPTPGLSVTSPSPTARPATPRTACLFPALCKTRKGEGTCPESLQDKKRRKNLNMEKLCKENEGKPESEGKPEDEVEPDNEGKSDEEEKPEVEGKSAHEGKLQNEGQPEDEGKPEDEGKQEKQGKSEDEGKPPGEGTMESQAKPESEPRAAEKRPAEDYVPRKAKRKTDRVTDDSPKDYEEDLQERHLGSEEMMREGGDLSRAQEELRKRQKMGGFHWMQRDVQDPFTPRGPRGVRGMRGGGRSQRGLHDIPYL", "length": 264 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1RYD7-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110258723", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "LLVVVLVTYLLTLVGNTVIILIASIDPNLKTPMYFFLTHLSLVDICLTTSIVPQLLWNLRGPAKTITTLGCAVQLYVSLALGSTECVLLAVMAFDRHAAICKPLHYAAVMNPRLCQALAGVAWLSGVGNALIQSTVTLWLPRCGHRRLHHFFCEVPSMIKLACVDIHTNEVQLFIASLVLLLLPLALILTSYGHIVKAVTRIKSVQAWRKALGTCGSHVMVVSLFYGTITAVYIQPNSSYAHTSGKFISLIYTVLTPTLNPLIYTLRNKDVKGAMRRLFRRDLGS", "length": 285 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1S4M2-1", "protein_name": "Small ribosomal subunit protein uS13", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLVILEKFQHILRVLNTTIDGWQKIAFATTAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVEHVITIMQNPGQYKIPDWFLNRQKDVKDGKYSQVLANGLDNKLHEDVERLKKIRAHRGLRHFWGLRVGGQHTKTTGRRGHTVGVSKKK", "length": 152 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1S6C0-1", "protein_name": "RING-type domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGNCLTPHTSEDLLVPASATHLGGRRRRARSRERRPRDQVPGWAPAAPLVQEEQVRVPQRISQIQCLPKGVYKRDGSQEKMEQEECAICTLDFVCGDPIRSLPCKHFYHLGCIDEWLTRSFTCPYCRGPADGPQPSSRDTP", "length": 141 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1S7I2-1", "protein_name": "Beta-defensin", "gene_name": "DEFB125", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNLLLTFMICGLLTLVTKAGWNVERCWSYNIGHCRRRCLHLERYKHLCMNKRACCIPLSSDDPYTQWPLPPEDQTVGMKTPYFRPVSPGSELDDQITITITVDQESTGTEQDIEGTAISFQASTPIPENIEDTKFSDKANTLNLHKL", "length": 147 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1S7N4-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100152708", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDQTNSSVVTEFVLVGLTQSLGMQFLLFLLFSTFYVGIILGNLFIVFTVISDSHLHSPMYILLANLSLIDLGLSSTTVPRMISDLFSDCKTISFHNCMIQMFFIHVTGGVEMVLLIAIAYDRYTAICKPLHYLTIMNPQMCMLLVVAAWITGVTHAVFQFAFVINLPFCGPNNVGSFYCDFPRVIKLACIDNYGLEFVVTANSGFLSTGTFFLLVVSYIFILVTVRQHSSKDLSKAFFTLSTHITVVFLFFLPCMFLYVWPFPTKSLDTFLAIVDFAVTPVLNPAIYTLRNRDMKVEMRRLSRQVISSREMT", "length": 312 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1SBB9-1", "protein_name": "DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MHALPAFESFLLFKDEKITIHKDTKAPNACLFTIDKEDHTLGNVIKSQLLKDPQVLFAGCQVPHPWEHKIIVPVQTTPDYTPQEALLNVITDLISKLSLLEERLRVAIKDKQEGIECWTGRGPAWPGPALTLALLQAPCG", "length": 140 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1SBV4-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100154723", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MESENITVVTEFIFVGLTQSRNIQLLVFVLVFIFYLIILPGNFLIILTIRSDPGLTAPLYFFLGNLAFLDASYSFIVAPRMLVDFLSEKKVISYRGCITQLFFLHFLGGGEMLLLVVMALDRYIAICRPLHYSTVMNPRACYALSLAQWLGGFVHSIIQVALILHLPFCGPNRLDNFFCDVPQVIKLACTDTFVVELLMVFNSGLLTLICFLGLLASYAVILCRVRGSSSEGKTKAMSTCTTHIIVIFLMFGPGIFIYTRPFRAFPADKVVSLFHTVIFPLLNPVIYTLRNQEVKTSLKKLLINN", "length": 305 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1SJ79-1", "protein_name": "Olfactory receptor", "gene_name": "LOC110259717", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEQNNGTKGTEFILLGFAGQHKSWPVLFIVFLVTYVVTLVGNIGMILLIKIEASLHTPMYFFLQNLEEKVDLCYATAITPKMLQNFVWTEHSISFIGCMVQLLTYGAFATSDCYILAAMAVDRYVAICNPLRYPTVMSQRVCIQLVIGSYFMGFLNASVNTSFTFQLNFCKSNKINHFFCDAPPILALSCSSIYFSIMLLAAFVGFNLTCTVSVVIFSYVFILAAILKISSAAGRKKAFSTCASHLTAVTLFYGTLSYMYLHHRTLESQEQEKLASVFYGIVIPMFNPLIYSLRNQDVREALKGVGKQCF", "length": 310 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1SLL7-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRRENQSSISKFLLLGLPIQPEHQGMFFVLFLVMYLTTVLGNLLIILLIRLDPRLHTPMYFFLSHLALTDVSFSSVTVPKMLMNMQTQDQSIPYAGCVTQTYFFIFLACIDNLLLAVMAYDRYVAICHPLHYAIIMREELCLCLLVLSWLLSCAYALTHTLLLAQLSFCADIIPHFFCDLDALLKLSCSDTSLSELVTFTAGAAVVIFPFIGILVSYGHIGLSILRVPSTKGICKALSTCGSHLSVVSLFYRTSMAVYLSSSGQFHDKDIIVSVMYTVVTPMLNPFIYSLRNRDMTLALGILFRNINIFSK", "length": 311 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1SMZ6-1", "protein_name": "10 kDa heat shock protein, mitochondrial", "gene_name": "HSPE1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQATVVAVGSGSKGKGGEIQPVSVKVGDKVLLPEYGGTRVVLDDKDYFLFRDGDILGKYVD", "length": 102 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1SRB7-1", "protein_name": "Large ribosomal subunit protein eL31", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAVVQKSGEKKRGRSAINEVVTREHTTSIHKRIHGVGSKKRAPRALKEIRKFAMTEMGTPDVRNDTRLNKAVWAKGIRNVPRRICAPLSRKRNEDEDSPNKLYPLVTCVPVTTFKNLQTVNEDEN", "length": 125 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F1SUB9-1", "protein_name": "Multifunctional fusion protein", "gene_name": "IL1B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MATVPEPAKEVMANNGDNNNDLLFEADGPKEMKCRTQNLDLSPLGDGSIQLQISHQLCNESSRPMVSVIVAKEKPMNPSSQVVCDDDPKSIFSSVFEEEPIVLEKHANGFLCDATPVQSVDCKLQDKDEKALVLAGPHELKALHLLTGDLKREVVFCMSFVQGDDSDDKIPVTLGIKGKNLYLSCVMKDDTPTLQLEDVDPKSYPKRDMEKRFVFYKTEIKNRVEFESALYPNWYISTSQAEQKPVFLGNSKGRQDITDFTMEVLSP", "length": 267 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F2Z5L2-1", "protein_name": "Histone H2A", "gene_name": "H2AC18", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK", "length": 130 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F4IWB9-1", "protein_name": "Cytochrome P450, family 705, subfamily A, polypeptide 28", "gene_name": "CYP705A28", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MIMGRSCSEKNGEAERVRGLVIESLALSPKIFLGMIFHKPLKKLGISLFQKDIKSVSPKFDELLEKFLVEHEEKMEEDHYKANDMMDLLLEAMEMRMQNVNLCIKRVSNTKARKPPILFRYGKYSNNSLLLQELLVAGTDTSALATQWTMAELINNPTILERLREEIESVVGNTRLIQETDLSNLPYLQSVVKEGLRLHPPASISVRMSQERCELGGFYIPEKTLLVVNTYAIMRDPNFWEDPEEFKPERFITSSRSEQEDEMREEVLKYIPFSAGRRGCPGSNLAYVSLGIAIGVMVQCFDWRIKGEKVNMSETAGTIMLAMAQPLKCTPVPRTLNLLPSSLHIPSS", "length": 348 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "F4J311-1", "protein_name": "Zinc finger (C2H2 type) family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDLDGVELLLDLREMVSQSGFEKSTTCSGVIALRSNLQSKSSHKCKICGKSFECYQALGGHQRIHRPIKEKLSKQEFSEVYPRKSKLQKRPESSSSCYECKVCGKIFGCYRGLGGHTKLHRSTKRELASTQDENSLLDSSEAKKIVSQPSSFKVSQEEKFLHCVELKQDFSEPLSHSGALPSTLRSKLQTKTQWKSSCHCKICGKSFVCSQGLGNHKRVHREISGKLACKRKYTEDYNPFSDSLKAKKIVKKPSSFEVSQEEKILHCVELKQDFGELLAHSGFDKSISCSKSIKVKKVARKNEKTEDSTSLFGVFVGEMSQRLHGCKTCGRKFGTLKGVYGHQRMHSGNHNRIEDENGLERIWGLKKKSRVCSVSAFDRFKGSSFMAEIEKHEVIEAALNLVMLCQGVYDFASISNLPLGDGFMDLELKPCPLRRKLQKKSRSSYKCSICEKSFVCSQALGSHQRLHRWKLVPKPEYIEDDSSLLDSSEAKKIVSKPSSFEHAQEEKILQCVEPKLEFHEQLAHSGFDKFDTCSKIRFSALPSPPEAKKIVSQPPSFEVSVDEKILYRAEPKLNFSEPLAHSCFDNSSSYRSIICGKSFVCSQALGGHQTLHRSIKGQLAGTEDGNSLSVTDSEASKIVAQPSSYKSQGI", "length": 650 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "F4JLV4-1", "protein_name": "Protease inhibitor/seed storage/lipid transfer protein (LTP) family protein", "gene_name": "DHYPRP1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MASTTIILFLSFSIIPLLTIVRADNHSVYCPPPPPCICICNPGPPPPQPDPQPPTPPTFQPAPPANDQPPPPPQSTSPPPVATTPPALPPKPLPPPLSPPQTTPPPPPAITPPPPPAITPPLSPPPPAITPPPPLATTPPALPPKPLPPPLSPPQTTPPPPPAITPPLSPPLVGICSKNDTELKICAGILAISDGLLTTGRAEPCCSIIRNVSDLDAVTCFCKSVGAPRFSLSPNFGIFFKVCGRRIPQGFSCPGPSPTISPPPLPPQTLKPPPPQTTPPPPPAITPPLSPPLVGICSKNDTELKICAGILAISDGLLTTGRAEPCCSIVRNVSDLDAVTCFCKSVGARRFSLSPNFGIFFKVCGRRIPQGFSCP", "length": 375 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "F4K5R6-1", "protein_name": "Cell division cycle 20.6, cofactor of APC complex", "gene_name": "CDC20-6", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MMKSIALALCLTHHSPMVLSIVDYGDSQEKTIDSLWKKPHGSDLTWSGFSRVGVTEAYFAVPVDHFLTNPPSLRLSQTIYCRRGSSYVETEKVEEEDRDDFLKQVWFLTDNLVFFFVDIEEYIVIEQLGDTVYLWDASSCYTSKLVTIDDENGPVTSINWTQDGLDLAVGLDNSEVQVWDCVSNRHVRTLRGGHESRVGSLAWNNHILTTGGMDGKIVNNDVRIRSSIIGTYVGHTEEVCGLKWSESGKKLASGGNDNVVHIWDRSLASSNPTRQWLHRFEEHTAAVRALAWCPFQASLLATGGGVGDGKINFWNTHTGACLNSVETGSQVCSLLWSKSERELLSAHGFTQNQLTLWKYPSMVKMAELNGHTSRVLFMAQSPDGCTVASAAGDETLRLWNVFGEPPKTTKKAASKKYTEPFAHVNHIR", "length": 428 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "F5H284-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase A-like 4D", "gene_name": "PPIAL4D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVNSVVFFEITRDGKPLGRISIKLFADKIPKTAENFRALSTGEKGFRYKGSCFHRIIPGFMCQGGDFTRPNGTGDKSIYGEKFDDENLIRKHTGSGILSMANAGPNTNGSQFFICAAKTEWLDGKHVAFGKVKERVNIVEATEHFGYRNSKTSKKITIADCGQF", "length": 164 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "F6R3J9-1", "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 1G", "gene_name": "Speer1g", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWRARRHTSSTAPDLSKKEFKKEKERLTTELHLLIQLRNEQRDHLIDFKESSNYNRTKPTQKKNPFYEQLRSTKNQVLSSVHKLEMGIIEAQENIQELNKWIDYFTNLHSQLLMEKNLKMSITQNKKNKEVEIDWALIEKYLVDLNLNGQTGADQQP", "length": 157 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F6X687-1", "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 1A", "gene_name": "Speer1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWRARRHTSSTAPDLSKKEFKKEKERLTTELHLLIQLRNEQRDHLIDFKQSSNYNRTKPTQKKNPFYEQLRSTKNQVLSSVHKLEMGIIEAQENIQELNKWIDYFTNLHSQLLMEKNLKMPVTQNQKNKEVEIDWALIEKYLVDLNLNGRTGADQQP", "length": 157 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F6YNI8-1", "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad19", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKNKGKGGKNRCRGKNENESEKRELVFKEYGQEYAQVTKMLGCGRLEAMCFDGVRRLCHIRGKLRKKVWINTSDIILVGLQDYQDNKADVILKYNLDEARSLKAYGELQEHAKINETDTFGPGDDDEIVFDDTGDDDEDIDDI", "length": 144 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F7AMQ8-1", "protein_name": "Exocrine gland secreted peptide 8", "gene_name": "Esp8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKVSAMTSFPVMLFLIILLLPSICSEERTQADPTISADNKKNFKTVVDLTDCQCERNFIESLESTLPASNQDQTLFENMTNQHKLNLSKMLSVLSKCCTQKQQVDTVHFRRMPHRIQSTKQNNYKKQVLYPMQEFMNLTRDVLVSRYV", "length": 149 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F7C9P2-1", "protein_name": "F-box and WD-40 domain protein 25", "gene_name": "Fbxw25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEIHLPSLPMLKILSYLDAYNLLQAAQVNKNWNALASSDVLWRKLCQRRWHYCDMVTLQLQGKETWKQFFIYRIWQEHAKTRAKPEDFTYKEIPVECGFYGYACYISGHGLTRNGQGKSVICMVSSKNTISTWDIHKSVITWVSPVQPASINLLTTLPDMHIAVTVDIQSTIKLWDCHNREALATNNLESPCKSLKAVISKDGPIVLVGDTLGNLYIFRIPDLHLISTVNVFPYGFDEIDCSPQKKWVLLSKNYPHILPKVFYMSSLLRTSEFSAPVSTILEFSLCQGAFWTPRREDRITLMSRSGFPQITKFETFDMKLEGIGNKVAVQGKLIASFFLPYYEESPNWIGVSDKDVIVCSTHFFLLLFTINGLHLQTFQYCPETIVRLCVDPVHVIVTCNNGSLDVYAWEERSLLLRKCYRLQNKRPLPLYGFINNLLCDDVSIVQLMRDGHGPYSLIAYALNICS", "length": 466 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F7ELE5-1", "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "gene_name": "Ndufs7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "RRTVVYTARARSQEKSGSEPLSLWFRFPLVSIWALDQNRNSLEDGPQRLSEGRGQDGGAGGSWLALCTDPGSAHRHSGSAAQSPPECGSHWEPEQSAVSKAGAGAVVPKPSHLPRSRAEYVVTKLDDLINWARRSSLWPMTFGLACCAVEMMHMAAPRYDMDRFGVVFRASPRQADVMIVAGTLTNKMAPALRKVYDQMPEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALLYGILQLQRKIKREQKLKIWYRR", "length": 271 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F7F947-1", "protein_name": "Beta-defensin-like domain-containing protein", "gene_name": "Spag11b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDLSQRPPNVFRHVVDFLKKNQTHITQACSGNSGGRKASSSDLCGCALCLEAPSPHSQLSYKRACSSCPPTRGSSVPAVPSTAMKQRLLPSFVNLLLAALLLPGKAETWLRSWTQALSAVVTLGSSSASSINHLVTEPPSSPQDEFPAQGGNGSGLLHHRVKRFPPRTPPYHEPGPNYQIVNCKKNEGFCQKYCNFMETQVGYCSKKKEACCLHPF", "length": 216 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F7FNC4-1", "protein_name": "Interleukin 36, gamma", "gene_name": "Il36g", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSKYPHSPCTASGKETPDLGQVSDVDQQVWIFRDQALVTVPRSHTVTPVTVTVLPCKYPESLEQGKGTPIYLGIQNPDKCLFCKEVNGHPTLLLKEEKILNLYHHPEPMKPFLFYHTLTGATSTFESVVFPGSFIASSKIGKPIFLTSKKGEHYNIHFSLDII", "length": 164 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F8VPX6-1", "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 4A1", "gene_name": "Speer4a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRANVNGRETREGRKDANLPPESNEGRRRWTWRMWMAHRQTTSSVPVTSKKQFEKEEKELIKKIQLTTKETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTYLHNLEMENMEARENKQEFKKEKNFYRNLHTRILLEENLIKKKLAILQQESKEIHADWAIIQERLVELNLSCKDEQEKTSNLETQENQVSEAARELGLATAEEDSILQNELPCQEAPAEHHTQNPPSSSDESSSDESSYSTCPAWE", "length": 267 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F8VQM2-1", "protein_name": "C-C motif chemokine ligand 26", "gene_name": "Ccl26", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFFDLGLLVLLAIFLSVQLGVATCGSSIAMSCCPNFSYYVIPWSWVYSYKFTDKSCTSDGVIFFTKTGKQFCVQPGAKWVQRFISLVNTRNHL", "length": 93 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G3GSG1-1", "protein_name": "Ferritin", "gene_name": "LOC100767129", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGFLRKSHRRQRHRCPLRVSRATVAYPLVFMTPPIISPPSQVRQNYHFDCKTAVNNHVQLQLHNSSVYLAMAFYFDSEDVAQKNLASFFLNKSHECTAQAEMFLELQNQRGGRISLGSIREADRNNWLGGLQAMECALQLELSTNQSLVALHQLASSKSDAHLCSFLKNHFLTKQVEVLKEISGYVTKLRQMGSPDDGIAEYLFGKLTLDDNKGK", "length": 215 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3GWA3-1", "protein_name": "60S ribosomal protein L18a", "gene_name": "LOC100764432", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKASGTLREYKVVGRCLLTPKCHTPPLYLMRIFALNHVVAKSRFWSQLKKMKSSGEIVHCGEVRPEVPLQVKNFAIWLHYDSRNGTYNMCREYWDLTVTQCYRDMGAQHCARTHCIHIMKVEEIASGKCQRPAVKQFHDSKIKFLLPHRVLRCQHKPHFTTKRLNTFF", "length": 168 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3H156-1", "protein_name": "Prefoldin subunit 4", "gene_name": "LOC100773780", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVATMKKAAAEDVNVTFEDQQKINKFARDTSRITEQKEIEVKKNHLQNLEDTFNDIMLADGDCFMTQYLIRDVLISHSQEEAQEMLEEAKKTLQEEIDALESRVGAIQWVLANLKVQLYTKFGSNINLGVDES", "length": 133 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3H2T6-1", "protein_name": "Histone H4", "gene_name": "LOC100757199", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG", "length": 103 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3H8X2-1", "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase gamma", "gene_name": "Agpat3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGLLAYLKTQFVVHLLIGFVFVVSGLVINFTQLCTLALWPISKQLYRRINCRLAYSLWSQLVMLLEWWSCTECTLFTDQATVDHFGKEHAVIILNHNFEIDFLCGWTMCERFGVLGSSKVLAKRELLCVPLIGWTWYFLEIVFCKRKWEEDRDIVKEGLQCLSDYPEYMWFLLYCEGTRFTETKHRISMEVAASKGLPPLKYHLLPRTKGFTTTVQCLRGTVAAIYDVTLNFRGSKNPSLLGILYGKKYEADMCVRRFPLEDIPADENDAAQWLHKLYQEKDALQEMYKQKGVFPGEPIKPARRPWTLLNFLCWATILLSPLISFVLGVFASGSPLLILTFLGFVGAASFGVRRLIGVTEIEKGSSYGNQELKKKE", "length": 376 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HAB3-1", "protein_name": "40S ribosomal protein S15", "gene_name": "LOC100759804", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAEVEQKKKRTFRKFTYCGVDLDQLLDMSCEQLMQLCSTRQRLLLNCSLWRKQHSLLKSLRKAKKKVPPMEKPEVGKTHLRDMIILPEMAGSMVDVYNGKTFNQVEIKPKMIGHYLGEFSITYKPVKHGGPGVGATHSSRFIPLK", "length": 145 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HDI6-1", "protein_name": "Lipid transferase CIDEB", "gene_name": "Cideb", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEYLSALNPNGLLRSVSTMGSELGRRVWNSGPPPQRPFRVCDHKRTVRKGLTAATRQELLDKVLETLLLSGVLTLVLEEDGTAVESEDFFQMLEDDTCLMALERGQSWSPRSGMLSYGLGREKPKHSQDIARITFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGVGPKKVLRELLRWTSSLLQGLGHMLLGISSTLRHVVEGAERWQWHKQNHLRS", "length": 219 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HDS5-1", "protein_name": "Histone H3", "gene_name": "LOC100773314", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA", "length": 136 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HGI3-1", "protein_name": "PHD finger protein 6", "gene_name": "Phf6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSSSIEQKKGSTRQRKCGFCKSNRDKECGQLLVSENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIKRGTKLMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEADLEETFNEHELEPSSPKTKKKSRKGRPRKTNFKGLTEDSRSTSSHGTDEMESSSYRDRSPHRSSPNDTRPKCGFCHVGEEETEARGKLHIFNAKKAAAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGKRMKCTLCSQPGATIGCEIKACVKTYHYHCGVQDKAKYIENMSRGIYKLYCKNHSGNDERDEEDEERESKSRGRLAIDQQLTQQQLNGN", "length": 364 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HJW3-1", "protein_name": "Calcium homeostasis modulator protein 6-like", "gene_name": "LOC100774768", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEKFKAVLDLQSKHRSALGYGLVTLLTAGGEKIFSEVVFQCPCSATWNLPYGLVFLLVPALALFLLGYALRTRTWRLLTGCCSWSASAQSSSGLQRVFVCAQISAAAALPPLTWVAVALLGGSFYQCAVSGSEAMARHLCKGRDPSCAAKLPQVPCKKQEAEMQDILSQLKAQSQVLGWILIAAIIILLLVVKSVTRCLSPVSYLQLKFWEIYLEKERQILQGEAMEHATQLAKENVRCFFDCTNPKDCSTPSSKAWQQISALYTFNPKNHFYSMLHKYVNRKDMSGSLRSVEGDAVVPVLGFVDASGMATTHGV", "length": 315 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HQ40-1", "protein_name": "Eukaryotic peptide chain release factor GTP-binding subunit ERF3B", "gene_name": "LOC100767578", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDLGSSSDSAPDCWDQVDMEVPGSAPSGDGFTSASTAAAEAAEAEAQRQHLSMAFSSQLNIHAKPFVPRVSAAEFVQSFLPGSAQPPAPTTSSSDETCTGAGDPQGKRLGWGAPVEPSKDGPLMSWEGSNSAVTMELSEPVVENGEVEMALEESWELKEVSEAKPGGSLGDSGPPEESGKEMMEEKEVIRKSKSMAIPSGAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDRRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKYLIVLINKMDDPTVDWSSERYEECKEKLVPFLKKVGFSPKKDIHFMPCSGLTGANIKEQSDFCPWYTGLPFIPYLDSLPNFNRSIDGPIRLPIVDKYKDMGTVVLGKLESGSIFKGQQLVMMPNKHNVEVLGIVSDDAETDFVAPGENLKIRLKGIEEEEILPGFILCEPSNLCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD", "length": 631 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HQN5-1", "protein_name": "Transcription factor 19 isoform X1", "gene_name": "Tcf19", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLPCFQLLRIGGGRGGDLYTFHPPSRSGCTYRLGCRADLCDVALRPQQEPGLISGVHALLHAELQGDDWRVSLEDHSSQGTLVNNVRLPRGHRLELSDGDLLTFGPEGQAGTSSSEFYFMFQQVRVKPQDFAAITVPRSRGEAGTGFQPMVPSQGAPQRPLSTLSSAPKATLILNSIGSLSKLQPQPLTFSRGGGRPQSLAVPTQPGEVGASPPAPPTRNRRKSVHRVLAELDDENETSLSPLSVLMEPRKKLRLEKAALVSSGRD", "length": 266 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3HWQ5-1", "protein_name": "Zinc finger protein 219", "gene_name": "Znf219", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEGSRPRILVGHLEPSPPAFDGELDLQHYSNGPGVSTGSPGMGAVGWSETRAGERRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARLLLELEERALLREAQLGRARSSGGMQATPATEGLARPQVPSSSAFPCPFCKGKFRTSAERERHLHILHRPWKCSLCSFGSSQEEELLHHSLTAHGASERPLAATSTPEPQPPPQPEPRSALEPEPEPEPRPEPEHEANPAPTPAPPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVHTSKLGPLRAPGPGSTPARAPQPPDMSLLAYEPLGPALLLAPAPTPAERREPPSLLGYLSVRAGEVRPNGEGADPGAGRSYGGGFRPLPSALPNRARRHRTEEPEEEEEVVEAEEESWARGRSLGTLTSLHPHPGEGSGQSAPAVGAQARPTGTQEENGLLVGGARSEAGRGATGKDCPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQRSSAGPGPPPEPPPPSPRGAASLQPQSGAKPTQASATWVEGTASTRPSSSGTGAGSRRKPASPGRTLRNGRGGEAEPLDLSLRAGPGGEAGSGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRQPRADTSPPYVRAPSGETPPSPPLEEEGSPGLSRSGEAGLGGQER", "length": 725 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3I071-1", "protein_name": "Large ribosomal subunit protein uL29", "gene_name": "LOC100753244", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAKIKARDLRGKKEELLKQLDDLKVELSQLRVAKVTGSAASKLSKIRVVQKSIVRVLTVINQTQKENLRKFYKGKKYKPLDLRPKKTRAMHRQLTKHEEKLKTKKQQRKERLYPLRKYAFKA", "length": 122 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3I1Z3-1", "protein_name": "DNA damage-inducible transcript 4 protein", "gene_name": "Ddit4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPSLWDRFSSSSSSSSSSSSGTPATDRPPRSAWGSAAREEGLDRCASLESSDCESLDSSNSGFGPEEDSSYLDGVSLPDFELLSDPEDEHLCANLMQLLQESLSQARLGSRRPARLLMPSQLVSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVAQLALDPSLVPTFQLTLVLRLDSRLWPKIQGLLSSANSSLVPGYSQSLTLSTGFRVIKKKLYSSEQLLIEEC", "length": 231 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3IAH8-1", "protein_name": "Guanine nucleotide-binding protein subunit gamma", "gene_name": "LOC100755128", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASNNTASIAQARKLVEQLKMEANIDRIKLSKAAADLMACCAAHAKEDPLLTPVPASENPFREKSFCTIL", "length": 70 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3IG76-1", "protein_name": "Olfactory receptor 7E24 isoform X2", "gene_name": "LOC100765597", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MYILALFGNLLIILTVSSDSHLHTPMYFFLSNLSMIDIGYISTTVPRVIVDIQTHCPVISYVGCLTQMSLIIIFACMDDMLLSVMAYDRFVAICHPLYYQVIMNPSSCGVLLLGSFLLSLVNLLLHYVAVLSFSNCEDIFEISNFFCGPSELFKLACFDTFTTNIVRYCAGALFGLLPISGIIFSYFKIVSSIMRSSSSSNGKWKTFSTCGSHLSIVCLFYGTALGMYFSSSLSLSPKTNAVASVMYTVVTPMLNPFIYSLRNKDIKTALRKILSRTF", "length": 278 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3IGD7-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100770882", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSGANSSSLTPEFFVLNGIPGLEDAHVWISLPFCFMYMIAVVGNCGLMYLIGHEEALHRPMYYFLTLLSFTDITLCTTTVPNTLCIFWFNLKKIGFKACLAQMFFVHTFTATESGMLMLMALDRYVAICYPLRYGTILTNPVIAKASLATFLRSVAFILPFTFLTKRLPYCRGNTIPHAYCDHMSVAKISCGNVKVNAIYGLLVALVVCAFDIFCITVSYTMILRAVMNLSSADARHKAFSTCTSHICAIVITYVPAFFNFFTHRFGGHTIPHHIHIIVANLYLLLPATMNPIVYGVKTKQIRESVIKFFSGDKSGITEIKGLQNK", "length": 326 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3INQ1-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100763177", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFCNTSTPGHSTFLLTGFPGLEASHHWVSIPINLICVVSILGNSIILFLIRTDPALHEPMYIFLSMLAASDLGLCASTFPTMVRLFWLGIRELPFDLCAAQMFFIHAFTYVESGVLLAMAFDRFIAIRDPLHYATILPHSAVAKVGAAVLIRAILLNLPGPILLRRLLFPQVSVLSHCYCLHCDLVGLACSDTRINSLVGLVSILLSLGLDSSLIMLSYVLILRTVLSIASPGERLKALNTCVSHLCIVLIFYLPKLGLSVLHRVEKHSYPALAVLMANLHFLVPPFMNPVVYCIKSKQIRQGFLKRFQQKRVDVS", "length": 316 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3MYE2-1", "protein_name": "Large ribosomal subunit protein uL18", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MGFVKVVKNKAYFKRYQVKFRRRQEGKTDYYARKRLVIQDKNKYNTPKYRMIICVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAVAYCTGLLLACRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGALTCYLDAGLARTTTGNKFFGALKGAVDGGLSIPHSTKQFPGYDSESKEFSAEVHRKHIMGQNVADYMRYLTEDEDAYKKQFSQYIKNNVTPDMEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLGQENDRVAQKKASFLRAQERAAES", "length": 295 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "G3MZM9-1", "protein_name": "Uncharacterized protein", "gene_name": "LOC107131211", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MNLFIYVLLLSIWTSSCLDRNESNGSATAVTTRAEFKQTKLQELRRRLLIIVIGTLITGYMVTCTCLLHYRCDSKEAHKAAKDKKEDITIKASRSSKISFTDSKSPTAGLGDPERQSVVSRIDKSSGPSSPRKVPSSAEKLVRPSSQKKPSKPSAPKKVLGSPPQEKLHRTRSPKKAHRQAHAHKLVSQVSPSYPEKAIKPTWPPSLQCRVKPTKTPLPYPKNQSFPEHSSADKLTKRQRYLKLKCPASAGRAEILSRPQPVKFCRCYKEKCLVCRAVSEPFITHVSEANKKHVPVPLFSRELKHFYKSYKKKQPKYNTLYGNMSDSDITTYNSDGESDREVIIMCNIKCKEDIYKNSPNN", "length": 361 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "G3UW31-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r176", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSQNKSVKTTVEVTLQILLLCQVGVGTVVNIFLFVHNLSPFLNGSQQRPIKVILANLALGNTLILLFAFPNNIRVFIPREFPTDLKCKLGYFIWLVARSTNMCSTCSLSTYQFVTLAPGTWGRVMLPGRAPNFLRYTCYSCWLFSVLNNAHIPMKVSGPQKTHNDSNSKSKWVCSTSGFSIGMRILSFAHDAVFISIIIWSSVSMVILLNRHHQRLQHIQSTNQKLRVHAETRASHTILLLVVTFVTCYLLDCICTVCNISFVDSRVWLRRVKEILSVSFPTFSPLLLIFRDPKDPCSLLFGC", "length": 304 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G3UY92-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r158", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQLLLLCQFGVGTVAKVFLFVRNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPTELKCKLESFSHLVARSTNLCSTCVLSFHQFVTLVPLNRGKGKLVLRASVTNMASYSSYSCWFFSVLSNIHIPIKVSGPQIKDNNTDSNRKLFCSTSGFSVGTVLLQFAYDATFMSIMVWASVSMVLLLHRHRQRMQHILTPNQDARGQAESRATRTILMLVVTFVSFYLLNFICIMLHALFMHSHFFVRLVSEILTAVFPSISPLLLIFRDPKDPCSVLFNC", "length": 307 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G3V9M0-1", "protein_name": "Cystatin S like 1", "gene_name": "Cyssl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MACLLYTQLFLLNTFILFLNLSLNPVLGQILAGIEKSIIEEEGALEALNFAVSEYNENNSDLYLSRVVEVKTVKTVQQQIEAGKTLLFDVILGKTACLKTQDDLSDCPLNEPTDLQEREFCSFEVHLPDWANAINLLSSICNRI", "length": 144 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3X693-1", "protein_name": "Ig-like domain-containing protein", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "RVFLPLLLLGVILPGGDNEDGPTSFHLIQISTFVNNTWAQNQGSGWLDDLQIHGWESDSGTAIFLKPWSKGNFSDDEVTELVDLFRAYFIGFTREVQDRVNEFQLEYPFVIQVTAGCELHSGEAIESSLRGALGGLDFVSIQNHSCVPAPDGSSRGQKFCALTTQYQGISDIIERLLSETCPRYLLGVLDAGKAELQRQVKPEAWLSSGPTPGPGRLLLVCHVSGFYPKPVRVMWMRGEQEQPGTQQGDLMPIGEAAGLNCRVKHSSLGDQDIILYWGHPTSIGLILVAIIVPSLILLICLAFGVLRFMGSHRIGHD", "length": 317 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "G3X9Q9-1", "protein_name": "Predicted gene 6526", "gene_name": "Gm6526", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLRRLFHRENGDQGETRPRQKESAIPSCKKRRMKSFWGRHMSAGKKSSQNCNITNHMKNMNKLEDMKFYIRKINAKRLELFPILDIDMNTDLNYRMNIEFTIIKSQHEKTMLDMEKMTQSISDTIETYKEFIEDKDSYSFTHSYLLKECNQLKEKVRMLLNENRKLLVEQADQEASYGEEKRFCDESSKNIHPKC", "length": 198 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G5E8X8-1", "protein_name": "Oocyte maturation, alpha", "gene_name": "Omt2a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDTLVFTKVHLESWVYKGLRGQHDSILELLKENLHHYLCIEFDEGLNDTVVYIIGFKFFAMFAMFVIVSLACNLRTKRNRARAWARGLQSPVWWNRRYFI", "length": 100 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "H3BJ46-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLSFMSSLLENILYFQAGLGVLANIFLLVFYIFIILGHRPKPMDLISCQLTFVHIMMFLAGENFWLANIFESLNVENDFKCKATFYTKRVMRGLSICITCLLSVFQAVMISHRNSLLAKFKHKLKIYMINALFYIWTFNLSLSSNLIFYVGGFTNMSQTKQLKVTKSCSLIPMNYIIRGLILTVISSRDMFLVGVMLTTSTYMVIILCRHQRQCKHLHSTSHLRASPEKRATQTILLLVVFFVIMYWVDFIISSTSILLWMYDPVIMIVQKFVVNAYPAITPFVQISSDTRVIRVVKNWHS", "length": 303 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "H3BJ88-1", "protein_name": "Vomeronasal 2, receptor 3", "gene_name": "Vmn2r3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMAIRKKCLILELTVFLCVELYAQYEDQNMTCRLMRKFNLTGYVEAENHHFVIGGQFPVHYRTIPTSDSDEEPESPMCEGFNFRGFRWMKTMIHTIKEINERKDILPEHTLGYQIFDNCFSTTKAMESSMVFLTGQDEYKPKWRNSTGKYLIGIIGAGGSTMSLAGARILLLNDVVQVGYASSSSILTEYLNVYRTIPSDKFQTEAIVNLIRHFGWVWIGAIASDDDYGKHGVKSFRKILETNNLCIAFSETIPKVYSNEKMQIAIDAVKSSTAKVIVLYATDFDLSPFVLEVIHHNIAHRTWIATEAWITSALIAKPEYFPYFGGTIGFAIPRSVIPGLKEFLYDVHPSKDPNDVLTIEFWQTAFNCTWPNSSVPYNVDHRVNMTGKEDRLYDMSDHLCTGKEKLKDLKNTYLDTSQLRITNNVRQAVYLMAYGLDRLIRVLIKEYREYLLHPKILAFMSYKLFEYIRKVKFTTHDGRKIELNVHGDIENGYYDILNWQMDNTGDIAIVKVGEYKFTRSKYELVLPKNSTLFWNTESSRLPDSVCTKVCPPGTRKGFITGQPVCCFDCIPCEDGYVSEKPGQRLCNPCSEDDWSNAEKNKCVPKHVEFLAYEEALGFTLVILSIFGALVVLAVTVVYVIHRHTPLVKANDRELSFLIQISLVITVLSTMLFIGKPCNWSCMARQVTLALGFCLCLSSILGKTISLFFAYRISISKTQLISMHPSFRKLIVLLCVFGEIGVCASYLVLKPPSMFKNIERQNVKIIFECNEGSVEFLCSIFGFDVLLALLCFVTTFMARQLPDNYYEGKCITFGMLFFFIVWISFVPAYLSTKGKFKVAVEIFAILASSYGLLGCLFLPKCFIILLRPKRNTDETVGGRVPTVDRSIQLTSASVSSELNSTMVSTVLDE", "length": 909 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "H3BKT1-1", "protein_name": "piRNA-mediated silencing protein C19orf84 homolog", "gene_name": "Gm52993", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDELEDGALSNGDNLSLPSAGTESWPTSATPGLPPSLLSTLDPTHLGLPEQLASVTVPIRLDTLSYLLHSALLGTYNLQQSLPPCSCTAQPSHIWPDTVRRPPRRSGQARGGWEVRRRPSRGWGRGRGRGRVWAQSQRGPERAEERERNMAGEPGAGPSTPPVTPPSQDGQKEAGGLSEDWEADY", "length": 185 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "H3BLP0-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLTNILYFQAGLGILANTFLLCFYTFTILCHRSKPMDLTSCQLTLAHILFLLAGGDNWLAVILESLNIENDFKCKAIFYTNRVMRGFSICITCLLSVFQAVTISPHTSLLAKFKHKLKTYIIYAVFYIWFYNFLVCSHLLVYVGGFNNVSETNQMRVTESCSLFLMNYIISGLIFTVTTFRDVFLVGVMLITNAYIVIILFRHQRHCKHLHSIRHLRVSPEKRATQTILLLMVFFVVMYWVEIIISSTSLLLWMYDPGFLTVQKLIVTVYPTITPLVQISSDKRVINVLKNLQSKCQQIF", "length": 302 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "I3ITL1-1", "protein_name": "Gap junction protein", "gene_name": "gjc4a.2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSWDFLTHLLDEISNHSTFVGKIWLTLLIVFRIVLTVVGGETIYDDEQSEFVCNTLQPGCKNVCYDAFAPLSHVRFWVFQIIMISTPSVMYLGFAMHKIARMADNEYQPRKHKMLSTVHQRMNRDYDMVDEMTEEVPMIPEEIEPSEKDNKSAASTKTTAASDAAVKHDGRRRIKRDGLMKVYVLQLISRVAFEIAFLFGQCILYGFEVSPSYICTRSPCPHTVDCFVSRPTEKTIFLLIMYVVSVLCLALTVLEILHLGIGGLRDSFRSRANRRLPVHRPSTSTICHRLSSAPPGYQAVQKKYSSGKLKAEFLSDSGRESLADDNTTRDLDRLRRHLKIAQQHLDQAYHTEEVGASHNSGPDSKSIAAEQNRLNQAQGGFGSTEEKVFKEAHA", "length": 394 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "I3L8A5-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "FPSRQERTMRRENQSSISEFLLLGLPIPPEQQGVFFALFLGMYLTTMLGNLLIILLIRLDPRLHTPMYFFLSHLALTDISFSSVTVPKMLMNMQTQDQSIPYAGCVTQMYFFMFFACLDNFLLTSMAYDRYVAICHPLRYTSIMRGGLCTLLVTVSWILSCANALCHTLLLAQLSICAENTIPNFFCDLGALLKLSCSDTSFNDLAIFIAGVATIMLPLLCILVSYGHIGATILKIPSTKGICKALSTCGSHLSVVFLYYGTIIGLYLVPSSSTSSHKDIVASVMYTVVTPLLNPFIYTLRNRDMKGALEKLFHKAPVLS", "length": 320 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "I3L8Z8-1", "protein_name": "LRRC37A/B like protein 1 C-terminal domain-containing protein", "gene_name": "LOC100514982", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMTLELEKLILPSHMACCLCQFKSNIEVVCKTVKLHCDRCLKNSTRCDKETSLGDVEGSFMKVLQARKKNTSTELMIEPERPSSDKSGVSLSSFMNEQLDFSDESDVISALNYILPYFSEGNLEDVESTLLPFIQLLFSNVAEADIPPGHLKTHTGNPPVNPESGTSGYTNKLRQLRFLENLLDAEIQEKIDEVMKKEKTAMLIYSNILSPKLRRQILRKKLETARTQAESLEEIESVDKRPLKVNRVLKGPRGIKKRHFRAMRRQSIRRKETAQPFVETTTKGSKLGGPSARELEQLWVVQRPRKRVADSLQKEPSFGREHKAEVSSFLKQYSRGRPAASIHPKAPATVKKTSEDLSDTLFVLVDANARVKNRKASETISYPRKIDSFHPSHSPVLHRTPEPQNRQAFRDKGSSYRLLLALRPLSSAVRSLINSPSQEASSPSGELTLQEQPSPESFSPSEPSTEHIISEKDTPQVVFEELPTSGTTTLSGPIPGPTAQGTLPTEYSATTADNVMPTGQHTSAIQWEHHNVGTDVASTPTSFISPGVSSPGSQFEAQLNQQLQSLIPNNDVRRLISHVIRTLKMDCSEPQVQLACAKLISRTGLLMKLLSEQQEAKASKAEWDTDQWKTENYINENTEAQGEQKESSELTKDVPGYGYNNKLILAISVAVVLMLLIVILCLIEVYSRRRTLREGKVGRRRGFFGFLLRKRRSGESESEGFFWRRRPLWLRDTYRPLSATRKKNMAEKLHDKESSDEEEIFHKGAGEVSEAPADVILTIESDVEDLGEETDTAPEGPPE", "length": 799 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "I3LBH4-1", "protein_name": "Large ribosomal subunit protein uL11", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPPKFNPNEIKAMYLRCTSGEISAKSALAPKIGPLGLSPKEVGDDIAKAAGDWKGLRITVKPTIQNRQAQMEVVPSASALIIKAPKELPRDRKKQKNIKHSGNITFDEIVNIARQMRRCSLARELSGTIKEILGTAQSVGCNVNGRRPHDIIDDISSGAVECQAS", "length": 165 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "I3LC12-1", "protein_name": "Olfactory receptor", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFGANLTIFHPTVFILLGMPGLEIYHTWLSIPFCLMSIVAVLGIGALILVVLSESTLHEPMHVFLSMLAGTDNLLSTTTVPKALAIFWFHAGEIAFDACITQMFFIHVAFVAELGILLAMAFDRYVAICALLRYTAVLTPSTIVKLTLAIWGWGIGTIFPIIFLLKRLPYCRTNIIPHSYCEHIGVARLACADITVNIWYGFSVPMASVLVDVAFIAVSYTLILQAVFRLPSQDAQHKALNTCGSHIGVILLFFIPSFFTFLTHRFGKNIPHHIHILLANLYVLIPPMLNPIIYGAKTKQIRDSLAHMLSRVGMS", "length": 315 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "I3LEQ2-1", "protein_name": "All-trans retinoic acid induced differentiation factor", "gene_name": "ATRAID", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARPGFRSPSSLVPRAAALLLVLSVPRALALPEICIQCPGDVQNLSEVALYCKQTPELMLQGRCCLNGKGTILGLDLQNCSLKDPGPDFAQAHTAVIIDLQANPFEGDWANTFRGFTQLQTLILPQGVNCPGGINAWDVVTFYITNQTCQGQRTFATALGTQKRVLRMDLVLLMVLVSCSVFVLMASMATSVCARAHSHCSCSSVFWDPQHYPFPSCFGGLNAEKPRLHEPQRSSY", "length": 236 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "J3QM75-1", "protein_name": "Secretoglobin, family 2B, member 19", "gene_name": "Scgb2b19", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGTLLLLGLLITGELSFQTTEACVPFFEGYASVVSGSRVWLYHELQSFDATAEEKVALEKIQGCYREERLRNILLEPKIMEAMVASPECRSYYSLNNFRSILDFISNLLGE", "length": 112 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QMG8-1", "protein_name": "T cell receptor alpha variable 13N-3", "gene_name": "Trav13n-3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKRLLCSLLGLLCTQVCWVKGQQVQQSPPASLVLQEGENAELQCTYSTTLNSMQWFYQRPGGRLVSLLYSPSWAEQRGGRLTSSAASNESRSSLHISSSQITDSGTYLCAME", "length": 112 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QML3-1", "protein_name": "BTB domain containing 35, family member 29", "gene_name": "Btbd35f29", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHQGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKKVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIIWDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYNEEQIVMKLDSDALTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QMQ9-1", "protein_name": "Predicted gene, 20873", "gene_name": "Gm20873", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLMKKRRRESSSNTLRNIVGRRISHSWKEGNEPVTQWKAIVLDQLPTNPSLYLVKYDGIDSIYGLELYSDDRILNLKVLPPIVVFPQVRDAHLARALVGRAVQHKFEGKDGSEVNWRGVVLAQVPIMKDLFYITYKKDPGLYAYQLLDDYKEGNLHMIPDTPPAEERSGDDSDVLIGNWVEYTRKDGSKKFGKVVYQVLANLSVYFIKFHGDIHIYVYTMVPKILEVEKS", "length": 232 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QMS5-1", "protein_name": "BTB domain containing 35, family member 2", "gene_name": "Btbd35f2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLSCRDSSLLEPQPEDIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKKVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QMW5-1", "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKNKGKGGKNRRRGKNENESEKRELVFKEYGQEYAQVTKMLGCGWLEAMCFDGVRRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADIILKYSPDEARSLKAYGELPEHAKINEMDTFGAGDDDEIMFDDIGEDDEDIDDI", "length": 144 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QMW9-1", "protein_name": "BTB domain containing 35, family member 6", "gene_name": "Btbd35f6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLSCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYRDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLQTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QN64-1", "protein_name": "BTB domain containing 35, family member 22", "gene_name": "Btbd35f22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDMKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYIDNISFLESEEGLIFQPVFKKLRFQHIIWDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYNEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QNQ5-1", "protein_name": "BTB domain containing 35, family member 24", "gene_name": "Btbd35f24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEGIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKDTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIIYDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QP08-1", "protein_name": "Histone H2A", "gene_name": "H2al1k", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKKMQRRRRQKRTRSQRGELPLSLVDRFLREEFHSSRLSSSALSFLTSVLEYLTSNILELAGEVAHTTGRKRIAPEDVRLVVQNNEQLRQLFKPGGTSVNEDDN", "length": 105 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QP87-1", "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKNKGKGGKNRRRGKNENESEKRELVFKEYGQEYAQVTKMLGCGRLEAMCFDGVRRLCNIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNQDEARSLKAYGELPEHAKINETDTFGAGDDDEIVFDDIGDEDEDIDDI", "length": 144 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QP96-1", "protein_name": "PRAME like 3C", "gene_name": "Pramel3b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMDTKDPPTLLDLATQSLLSNEHAAIQALEEIPRELFVPLFTAAFTGRHKNILTAIVKAWPFACLHIGALSVQEPERELLKALIESLQFLPALNSATRSPKLRILDLRQDAGCKTVCPDISTNSTICFRSCAHSEHSIFKIEGQESLSSSKSEAQPSRLPMELIVDISLDGTLRERNFFALLQNKVEQSLGSLHLCCRDLQINNLCECRHALSHLDLKCVDHLAVDESPLTEVTKLLSHTIQLDSLSLSKIACRSLNGRTFRNFITQLSRMNHLKELSLSSFCLTDHLETVLRVLSADLEFLYLPFCGLSYSDFKFLSECSQVSHLKLLNVNNNPIYWEDCEPFYYLLQNVSSTLQHLKICYCFLTDSTISVLIPALTRCSQLRVLHFYSNQITMGMLMRILELLTPLKELKHVIYPIPVHCYGRWHFQGSLDRQKVEDVQRQLNLMLQEAERSDMNWITYSD", "length": 463 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QPI8-1", "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKNKGKGGKNRRRGKNENESEKRELVFKEYGQEYAQVTKMLGCGWLEAMCFDGVRRLCHIRGKLTKKVWINTSDIILIGLRDYQDNKADVILKYNPDEARSLKAYGELPEHAKINEMDTFGAGDDDQIVFDDIGEDDEDIDDI", "length": 144 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "J3QQ02-1", "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ad11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKNKGKGGKNRRRGKNENESEKRELVFKEYGQEYAQVTKMLGCGRLESMCFDGVRRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNPDEARSLKAYGELPEHAKINEMDTFGPGDDDEIVFDDIGDDDEDIDDI", "length": 144 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7GP63-1", "protein_name": "Large ribosomal subunit protein eL39", "gene_name": "RPL39", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL", "length": 51 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "K7N5V5-1", "protein_name": "Predicted gene 5862", "gene_name": "Gm5862", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRVNVDGRETREGRKDADLPSERNEGRRRWTWRMCMAHRQTTSPVPVKSKKQFEKEEKELIKKIQLTTEETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTYLHDLEMKNMEARENNQELKKEKNFYRNLHTRILLEENLIKKKLVILQQESKEVHADWATIHQSLVELNLSGKDEQEKTSNLETQEHQVSEAARELGLATAEEDSILQNELPCQEAPAEHHPQHPPSSSDESSSDESSYSTCPEWE", "length": 267 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N660-1", "protein_name": "Predicted gene 10220", "gene_name": "Gm10220", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRVNVDGRETREGRKDADLPSERNEGRRRWTWRMCMAHRQTTSPVPVKSKKQFEKEEKELIKKIQLTTEETNELRDRLIYVTEGSMNKRPYHRQTRHYKELKLKEKEIMTYLHDLEMKNMEARENNQELKKEKNFYRNLHTRILLGENLIKKKLAILQQESKEIHADWAIIQQRLVELNLSGKDEQEKTSNLEAQENQVSEAARKLGLATAEEDSILQNELPCQEAPAEHHPQHPPSSSDESSSDESSYSTCPSWE", "length": 267 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6B6-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r168", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSQNGAMKTTEEVALQIVLLCQFGIGTMANILLFVHNFSPLLTGCQLRPKEVICANMAVSSILILFMTVFPNNVFVAQRNLLNDLQCKLEYFVYMVARSTNLCSTCVLSTYQFVTLVPGNFSELMVRGRSPKVISYSCCSCWLFGILYNVYIPMKVSGPQNRHNKTSTKSKWVCFTSGFSVGIVFLSFAHDAIFISIMVWASVSMVRLLYRHYQRLQYIFPPHQGNRGYAEIRAAHSIVLLVVTFVSFYLLHCICFILHIVFVDSNLWLRHIGEVLTSSFPTISPLLLIFRDPSYPCSLIFNYKKPVI", "length": 309 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6B7-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Gm10670", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVRGKSLKTTEEVALQIILLCQFGVGTMANDFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTVFPNNMMAFAPRNPPTELKCKLKFFSHLVTRSTNLCSTCVLSMHQFVTLVPISRGKLLLRASVPNLVSYSCYGCWFFSVLSNIHIPIKVTGPQITDNNTDSKSKFFCSTSGFTVRIVFLQFSHDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQNPRGQAESRATNTILMLVVTFVSFYLLNFICIIFHTFFIHYNLFIRLLGEILAAGFPTISPLLLIFRDPKNPCLELFHCFKPESLQNLKHRRQLH", "length": 321 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6G6-1", "protein_name": "Predicted gene 16440", "gene_name": "Gm16440", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLRRLCQKENGDEGEIRTTEKEEGILSHEKGRRKSFWRRHRSARNTSTQNSKITKQRSKINELEELKLDMRKISNDMEEMGGILELYIYEDLNYRMNTEFNIIKSQHEKTMLDMNEMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLSEKVRILLNENRKLLVEQAGTQLSHEEEKRFCEEASKNICASSAKEQQCVNSSRNRNMAQTTT", "length": 218 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6J5-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r127", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHGKSVKTTEEVALQLLLLCQFGVGTLANVFLFVHNFSPVLTGSKQRPRQVILSHMAMANALTLFLTIFPNNMIAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIHQFVTLVLVNRGKLILRASVPNFVSYSCYSCWFFSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVFLQFAYDATFMSIMVWTSVSMILLLHRHRQRMQHILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNFICIIFHTLLMHSHLFIRLVSEVLTAVFPSICPLLLIFRDPKDPCSVLFNC", "length": 305 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6P1-1", "protein_name": "Reproductive homeobox 2H", "gene_name": "Rhox2h", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKRSINYLLDVGPEEDEENANGVKTLMVLLAGEGRNEGESGRGLPGSGVSAAEGYRAGELSAGGPAAPVAGLMDNSNQEDLSATGCAQEKETQPEEPVPDSMGDLENVKPMSGPWSTVNPVRVLVPKFRHLWRHNFNVLQLQELESIFQCNHYISTTEENRLARSMGVSEATVQEWFLKRREKYRSYKRL", "length": 191 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6T9-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r175", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLQNKSVKTTEEVALQVLLLCQVGFGTAVNIFLIVHNLSPILNGSQQRPIKVILANLAVGNTLILLFAFPNNMTLFVPKDPPTDLKCKLGYFIWLVARSTNMCSTCFLSTYQLVTLAPGTWGRVMLRGRAPKFVRYICYSCWLFSVLNNAHIPMKVNGPQKTHNDTNTKNKWVCSTTGFSIGMRILSFAHDAVFISIIIWSSVSMVILLNRHHQRLQHIQSTNQKLRVHAETRASHTILLLVVTFVTCYLLDCICTVCNISFLDSRVWLRRVKQILDVSFPTFSPLLLIFRDPKDPCSLLFCC", "length": 304 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6U2-1", "protein_name": "Predicted gene 3542", "gene_name": "Gm3542", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSRLLRLCQKENGDEGETRPKKKEEGILSHEKGRRKSFWRRHRSARNTSTQNSNITNQISNINKVEELKLHIRKTSNERKEMCGILNVYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLNEKVRILLNENRKLLVEQAGTQVSCEEERGSLRRPARTSVPQVQRNSSFPKCETVQQKLEHGTDHDMISLKEKCWWKRTGCAQEIHHCCLSSLITMAVMGCMLLLYFGFLGMNRP", "length": 270 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6W5-1", "protein_name": "Predicted gene 17019", "gene_name": "Gm17019", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALFARLCRLFQRANVDGRDTREGRKDADLPSERNEGRRRWTWRMWMALRQTSSPVPVISKKQFEKEEKKLIKEIQLTTEETNELRDRLIYVTEGSMNKRPYHRQNPLYEKLKLKEKEIMTFLHNLEMENMEAQENKQELKKETHFYRNLHSRLLMEENLIKKKSMTLQQESKEVQADWAIIHQRLVELNLSVKDEQENSNLETPEYQVSEAARELGLATAEEDSILQNELPGQEAPAEHHLQHPQSSSDESSSI", "length": 255 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6W9-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r170", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLQNKSVKTTEEVALQVLLLCQVGVGTAVNIFLIVHNLSPNLNGSQQRPIKVILANLAVGNTLILLFAFPNNMTLFVPKDPPTDLKCKLGYFIWLVARSTNMCSTCSLSTYQLVTLAPGTWGRVMLRGRAPKFVRYICYSCWLFSVLNNAHIPMKVSGPQKTHNDTNTKNKWVCSTTGFSIGMRILSFAHDAVFISIIIWSSVSMVILLNRHHHRLQHIQSTNQKLRVHAESRASHTILMLVVTFVTCYHLDCICTFCNISFLDSQLWLRRVKQILDASFPTFSPLLLIFRDPKDPCSLLFCC", "length": 304 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6X3-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r94", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHGKSVKTTEEVALQLLLLCQFGVGTLANVFLFVHNFSPVLTGSKQRPRQVILSHMAMANALTLFLTIFPNNMIAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIHQFVTLVLVNRGKLILRASVPKFVSYSCYSCWFFSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVFLQFAYDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQDARGQAETRATHTILMLVVIFVSFYLLNFICIIFHTLLMHSHLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFNC", "length": 305 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6X7-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r103", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHGKSVKTTEEVALQLLLLCQFGVGTLANVFLFVHNFYPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMIAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIYQFVTLVLVNRGKLILRASVPNFVSYSCYSCWFFSVLSNIHISIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVSLQFAYDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQYRRGQAETRATRTILMLVVTFVSFYLLNFICIIFHTLLMHSHLFIRLVSEVLAAVFPSISPLLLIFRGPKDPCSVLFNC", "length": 305 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6Y3-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r115", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHGKSVKTTEEVALQLLLLCQFGVGTLANVFLFVHNFSPVLTGSKQRPRQVILSHMAMANALTLFLTIFPNNMIAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIHQFVTLVLVNRGKLILRASVPKFVSYSCYSCWFFSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVFLQFAYDATFMSIMVWTSVSIILLLHRHRQRMQHILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNCICIIFHAFYIHSRLFIRLVSEVLAAVFPSICLHNGVLLSY", "length": 295 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N6Z0-1", "protein_name": "Predicted gene 17026", "gene_name": "Gm17026", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "XRSSWVPKQACCPCSSGYFRERIEYTQTPDQGRRRPAAHHGGKGQETTGHGEGSAGAASPQAPTINDQEKRHERLEKLKRELQNIKNARDELQGILANYTNKDLNDRINFETFMLQMQHDQVMTDLKRMPQDISEALYKCKQLTKENQFYCFRNCHLLIESNLIQHKVRMLRKENRQLLREQIALEECNIETKILCKEGSQKIKDHYTKQQQI", "length": 213 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N701-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r159", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHGKSVKTTEEVALQLLLLCQFGVGTLANVFLFVHNFYPVLTGSKQRPRQVILSHMSVANALTLFLTIFPNNMIAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIHQFVTLVLVNRGKLILRASVPNLVSYSCYGCWFFSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVFLQFAYDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQNTRGQAESKATRTILMLVFTFVSFYLLNFICIIFHTLLMHSHFFIRLVSEVLAAVFPSISPFLLIFRDPKDPCSVLFNC", "length": 305 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N708-1", "protein_name": "Predicted gene 10128", "gene_name": "Gm10340", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLLRLFQKENGDEGETRPTEKEEGILSHEKGRRKWLWRRHRSARNTSTQNSKMTKKRSKRNELEELKLDMRKISNDMEEMCGILNLYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLHENVRILLNENRRLLVEQAGHKCPVGKKRGSLRRPARTSVSQVPRNTSVI", "length": 205 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N731-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r57", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVLALNILLLCHVVVGTVGNILLFVHNFSPNLTDSRLRPIQVILINLAVANAFMLLFSTYSYDLIDFVPRKPPTDLKCKLAYFFHMVARGTIMCSTCVLSTYQFVTLVPGNWARVMFREISPKVVSYSCFSCWLFSVLNNAYIPMNVSGPQKSHNDSDSKDNWICSISGVSVDMNFLRFSHDIIFLGIMAWTSVSMVIHLNRHHQRMNHIHKVNQNNRGHAETRAAHTILMLVVTFVSLYILNCIIILFHITFVESRLSLRHVTKLLSLSFPTISPLLLIFREPRGHCSLLFSVGLEIHVTGGVITEEQ", "length": 310 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N744-1", "protein_name": "Predicted gene 8104", "gene_name": "Gm8104", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLRRLFHRENGNQGETRPRQKESAIPSCKNRRMKSFWGRHMSAGKTSSQNCNITNHMKNMNKLDDMKFYIRKINAERLELFRILDIDMNTDLNYRMNIDFTIIKSQHEKTMLDMEKMTQSISDTIEKYKEFIEDKDSYSFTHTYLLKECNQLKEKVRMLLNENRKLLVEQADQETSYGEEKRFCDETSKNIHPKC", "length": 198 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N751-1", "protein_name": "Predicted gene 3696", "gene_name": "Gm3696", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLLRLFQKENGDEGETRPKKKEEGILSHEKGRRKWLWRRHRSARNTSTQNSKMTKKRSKRNELEELKLDMRKISNDMEEMCGILNLYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLNENVRILLNENRRLLVEQAGHKCPVGKKRGSLRRPQEHLCPKCQGTAV", "length": 203 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K7N757-1", "protein_name": "Predicted gene 3667", "gene_name": "Gm3667", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLLRLFQKENGDEGETRPTEKEEGILSHEKGRRKSFWRRHRSARNTSTQNSKMTKKRSKINELEELKLDMRKISNDMEEMCGILNLYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLNEKVRILLNENRRLLVEQAGHKCPVGKKRGSLRKPARTSVSQVPRNSSVK", "length": 205 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K9J7F4-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r260", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGNSLKTTEEVALQILLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPTELKCKLESFSHLVVRSTNLCSTCVLSVHQFVTLVPLNRGKGKLVLRASVTNMASYSSCSCWFFSVLSNIHIPIKFSGPQITDNNTDSKRKLFCSTSGFSVGIVFLQFAYDATFMSIMVWTSVSMVLLLRRHRQRMQHILTPNQNPRGQAESKATHTILMLVFTFVSFYLLNCICIIVHALFMHSHFFVRLVSEILTAIFPSISPLLLIFRDPKDPCSVLFNC", "length": 307 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K9J7G0-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r163", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCQFGVGTVANVFLFVHNFSPVMTGSKKRPRQVILSHMAVANALTLFLTIFPNNMSAFAPKTPPTELKCKLEFFSHMVARSKNLCSTCVLSIHQFVTLVPVNRGKGKLILRASVPNLWNYSCYSCWFYSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGMVFLKFSHDATFMTIMVWTSVSMVLLLHRHHQRMQHILTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPNICPLLLIFRDPKDPCSVLFKC", "length": 307 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K9J7G4-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r242", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVHDKSVKTTEEVALQLLLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPNELKCKLESFSRLVARSTNLCSTCVLSIHQFVTLFPVSRGKGKLILRASVQNLASYSCYSCWFFSVLSNIHIPIRVTGPQITDNNTDSKSNLFCSTSGFIVGIVLQFAHDATFMSIMIWTSVSMILLLHRHCQRMQDILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNCICIIFHAFFIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSLLFKC", "length": 306 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K9J7H2-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r256", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSLKTTEEVALQLLLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILGHMAVANALTLFLTIFPNNMMAFAPKTPPNELKCKLESFSLLVARSTNLCSTCVLSIHQFFTLFPVSRGKGKLILRASVQNLASYSFYSCWFFSVLSNIHIPIRVTGPQITDNNTDSKSNLFCSTSGFIVGIVLQFAHDDTFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQNPRGQAESRATHTILMLVFTFVSFYLLNCICIIFHAFSIHSCLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 306 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "K9JA28-1", "protein_name": "Interferon lambda receptor 1", "gene_name": "IFNLR1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAWRIRVLATLCFLWQPRVHGQLPPPQNVTLLSKDFDMILTWTPGEGSPPDVLYTVRYESKTRMDKWIKVPHCRNIHSVSCNLTCVIPNFFIKFRAQVKATSGRFHSPWVKSQFKEYHLDVELAPPLLNVNVKENVIHVNATFPMAICVESLPWMYDFNLWEAGSEDKKQYKSIFRKKAVTIDTTALRGNYCFNARSSIQSIDFKHSKFSQPVCMQLNYEGEWKFPFSATIPVFVLLILLTSASIIWLLKQDAKHKKMPQTLDLSNCKIAGPTFCCELRENEFLTDCLICTDKPMSQGKKNKTLAQNNQMWMASFLPSSSSEEEEEEEEEDSSSFIPYTEMLQFPRKHFNFQTPRTADAETILDSTSGVLSVVGGSTLDLSALGFSFFPIRKNEMDTSGSQGNEKASHSHSSSLGRISLTDVRFPGPREHGQHGTDSNDCLEVSLLHTLMNSSCTRLPADEHCLYKKDHDFTICYQKPTLDQPVQVSENPLLNEDPSMEKFIYLQTLQVAEDEGFASDCDSGNFTEGTPPASTVLSDELRISDMEKRYDKKFKFKGYQHSHYMRRS", "length": 567 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "L7MU37-1", "protein_name": "Reproductive homeobox 3H", "gene_name": "Rhox3h", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSMKPERSISNWIHSNVEPAGRNLFQVNGHRSALLPELPQDYHRASRSVNGCETKMDSTQGTKVLPAEESRNEEDGGQVESALGATAARGRGKEALNGESPAAAGTAGLVEEDRNKEDGGTKGGEKNEQEVREQIPEHVEGESDQAEAPRQVPRRRLHHRFTQWQLDELERIFRMNYFLSLEARKQLARWMGVNEAIVKRWFQKRREQYRWYKRL", "length": 215 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7MU51-1", "protein_name": "Olfactory receptor", "gene_name": "Or4a76", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGQSNNVTEFVLLGFTQDPAGQKALSVMFSLIYIVTMVGNLLIVGTVIASPSLGSPMYFFLASLSLMDAIYSTAITPKLIVDLLCEKKTISFRACISQLFIDHLFGGVDIVILLAMAYDRYVAICKPLHYLIIMNRRVCILFLVMAWAGGLAHALFQVLAVYNFPFCGPNIIDHFGCDIYPLLLLACTDTYFLGLSIIGNNGAMCIVIFTLLLLSYGIILRFLKNHSQEGRRKALSTCGSHITVVFLFFVPCIFMYVRPVSSFPIDKFITVIYTIVTPMLNPLIYTLRNSEMKNSMEKLLQKTLSPSRIRLSSCCLCY", "length": 318 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7MU81-1", "protein_name": "BTB domain containing 35, family member 17", "gene_name": "Btbd35f17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANTWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7MU83-1", "protein_name": "BTB domain containing 35, family member 18", "gene_name": "Btbd35f18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDQVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7MUB9-1", "protein_name": "Reproductive homeobox 2G", "gene_name": "Rhox2g", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERQSINYKLDVGPEEDEENANGIKTLMVLLAGEGRNEGESGRGLPGSGVSAAEGYRAGELSAGGLAAPVADLMDNNNQEDLGATGCAQEKEKQPEEPVPDSMGDLENVKPMSGPWSTVNPVRVLVPEFLHGWQQSFNVLQLQELESIFQCNHYISTTEAKCLARSMGVSKATVQEWFLKRREKYRSYKRL", "length": 191 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N1X6-1", "protein_name": "F-box/WD repeat-containing protein 15", "gene_name": "Fbxw15", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAIHLPCLPMMKILSYLDAYSLLQAAQVNKDWNELASSDVLWRKLCQKRWLYCDMDTLQLQGKETWKQFFIDRIWQERAKFRAKAKDFTYKEIPLMCGLFGYACYISGCGLTRKGQDKSVVCMVNSKNTISTWDVHKSVITWKSPEQPASIKLLTTLPEMHIAVTVDIQSTIKLWDCHNREALATNNLKSPCKSLKAVFTKDGPIVLIGDTLGNIHIFRIPDLYLISTVNVLPYGFDGIYCSPQKKWVLLSKKHPHILPKVFYMSSFLRTSEFSAPVSTVLKLSLYERVFWTPRREDRITLMSRSGFPQVKMFETYDIKLEEFGNKRIVKGKLIASFELQCHKVNPQRFGVSDKNVIVCSTESSLLLFDINGLRLKTFQYCPEMIVKLSVDPLHVIVICNTGSMDVYAWEERSLLLRKCYRLHIERPLPLYGFIYKAACDDVSIIQLITDELSLSSLTSYALNICS", "length": 466 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N1X9-1", "protein_name": "Demilune cell and parotid protein 1", "gene_name": "Dcpp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFQLEAMLALLILAFLGTPTVLTQDYHGPEVGKHSCTSAPEGKNITSIRVFLKGRLIVGIQLNYDDNKDGQVYGSTAGKEMVARLSKEEHIIAAQGTYTPSALTQIIFTTNQPRQLMVGYYVGNSEYSSFPNDPSHVLKGACVSWRAGGIKSILFLWGSENSSCVKYGHSG", "length": 171 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N1Y3-1", "protein_name": "PRAME like 51", "gene_name": "Pramel51", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIHSKERKYRLGLLEPGVTAFPCPNMVICLHCPDQDDSLEEVTEECYSPPTLQNLAIQSLLRDEALAISALTDLPQSLFPVIFEEAFTDGHIGILKAMIPVWPFPYLSLGKQINNCNLETLKAMLEGLDILLAQKVQTSRCKLRVINWREDDLKIWAGSHEGEGLPDFRTEKQPIENSPGCEVKKELKVTTEVLRMKGRLDESTTYLLQWAQQRKDSIHLFCRKLLIEGLTKASVIEIFKTVHADCIQELILRCICIEELAFLNPYLKLMKSLFTLTLDHIIGTFTLGDSEKLDEETIFSLISQLPTLHCLQKLYINDVPFIKGNLKEYLRCLKKPLETLCISNCDLSQSDLDCLPFCLNICELKHLHISDIYLCDLLLEPLGFLLERVGDTLKTLELVSCCIVDFQFSALLPALSQCSHLREVTFYDNDVSLPFLKQLLHHTALLSQLIYECYPAPIECYDDSGVILTHRLESFCPELLDILRAKRQLHSVSFQTTKCSKCGGCYIYDRHTQCCRFVEL", "length": 520 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N1Y5-1", "protein_name": "Olfactory receptor", "gene_name": "Or11g25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTLSSPSNSSTITGFILLGFAYPREGQILLFVIFFIVYILILMGNASIICAVYCDQRLHTPMYLLLANFSFMEIGYVTSTVPNMLANFLSDTKVISFSGCFLQFYFFFSFGSTECFFLAVMAFDRYLAICRPLHYSSLMTGRLRNTLVTSCWVLGFLWFPVPIIIISQMSFCGSRIIDHFLCDPGPLLALACSRVPLIEVFWSIIMSMLLVIPFLFIMGTYILVLRAVFRLPSREGQKKAFSTCGSHLTVVSLFYCSVMIMYLSPTSEHEAGMQKLVTLFYSVGTPLLNPMIYSLRNKDMKNALQKILRT", "length": 311 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N227-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r125", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSMKTTEEVALQIILLCQFGIGTVANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMSAFARKTPPTELKCKLEFFSHMVARSTNLCSTCVLSVHQFVTLVPVNRGKGKLILRASVPNFANYSCYSCWFFSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGMVFLQFSHDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 307 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N255-1", "protein_name": "Predicted gene 3099", "gene_name": "Gm3099", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSRLLRLCLKGNGDEGETRPKKKEEGILSHEKGRRKLFWRRHRSARNTSTQNSNITNQISNINEVEELKLHIRKISNERKEMCEILNVYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMTQFIIGSMQYSMELIEDNYSYSIKEDHLLRECTQLNKKVRILLNENRKLLVEQAGTQVSCGEEKRFCEEASKNICASSAKEQQLP", "length": 205 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N259-1", "protein_name": "Demilune cell and parotid protein 3", "gene_name": "Dcpp3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFQLEAMLALLILAFLGTPTVLTQDYHGPEVGKHSCTSTPEEKNITSIRVFLQARSIVGIQFNYDDKDGQVYGSTAGKEMVARLSKEEHITGVEGSYSPSALTQIVFTTTQPRQLMVGYHVGIYQYSSYPDDPSFVLKGACVSWRAGGIKSILFLWGSENSSCVKYGHSG", "length": 170 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N270-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r123", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSLKTTEEVALQLLLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILIHMAVANALTLFLTIFPNNMSAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIHQFVTLVPVNRGKGKLILRASIPNLWNYSCYNCWFYSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGMVFLQFAYDATFMIIMVWTSVSMVLLLHRHRQRMQHILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNFICIIFHAFSIHSHLFIRLVSVVLAAVFPSICPLLLIFRDPKDPCSVIFKC", "length": 307 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N273-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r118", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVHDKSVKTTEEVALQLLLLCQFGVGTVANVFLFVHNFSPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMMAFAPKTPPNELKCKLESFSRLVARSTNLCSTCVLSVHQFVTLFPVSRGKGKLILRASVQNLASYSCYSCWFFSVLSNIHIPIRVTGPQITDNNTDSKSNLFCSTSGFIVGIVLQFAHDATFMSIMIWTSVSMILLLHRHCQRMQDILTPNQNPRGQAETRATRTILMLVVTFVSFYLLNCICIIFHAFFIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSLLFKC", "length": 306 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N275-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r169", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSQNKSVKTTVEVALQILLLCQVGVGTVVNIFLFVHNLSPFLNGSQQRPIKVILANLALGNTLILLFAFPNNIRVFIPREFPTDLKCKLGYFIWLVARSTNMCSTCSLSTYQLVTLAPGTWGRVMLHGRAPKFVRYTCYSCWLFSVLNNAHIPMKVSGPQKTHNDTNTKSKWVCSTTGFSIGMRILSFAHDAVFISIIIWSSVSMVILLNRHHQRLQHIQSPNQKLRFHAETRAAHTILMLVVTFVTCYLLDCICTSLHISFVDSRVWLRRVKEILAVSFPTFSPLLLIFRDPKDPCSLPFSC", "length": 304 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N288-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r151", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHGKSVKTTEEVALQILLLCQFGVGTLANVFLFVHNFYPVLTGSKQRPRQVILSHMAVANALTLFLTIFPNNMIAFAPKTPPTELKCKLEFFSHMVARSTNLCSTCVLSIYQFVTLVLVNRGKLILRASVPNFVSYSCYSCWFFSVLSNIHISIKVTGPQITDNNTDSKSNLFCSTSGFIVGIVSLQFAYDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQYRRGQAETRATRTILMLVVTFVSFYLLNFICIIFHTLLMHSHLFIRLVSEVLAAVFPSISPLLLIFRGPKDPCSVLFNC", "length": 305 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N2A6-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r116", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCQFGVGTVANVFLFFHNFSPVLTGSKQRPRQVFLSHMAVANALTLFLTIFPNNMSAFAPKTPPNELKCKLEFFSHMVARSKNLCSTCVLSIHQFVTLVPVNRGKGKLILRASVPNLWNYSCYSCWFYSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGMVFLQFSHDATFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLAAVFPSICPLLLIFRDPKDPCSVLFKC", "length": 307 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N2B4-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r128", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHGKSVKTTEEVALQILLLCQFGVGTVANVFLFVHNFSPVLTGSKKRPRQVILSHMAVANALTLFLTIFPNNMSAFAPKTPPTELKCKLEFFSHMVARSKNLCSTCVLSIHQFVTLVPVNRGKGKLILRASVPNLWNYSCYSCWFYSVLSNIHIPIKVTGPQITDNNTDSKSNLFCSTSGFIVGMVFLQFSHDATFMTIMVWTSVSMVLLLHRHHQRMQHILTPNQDARGQAETRATHTILMLVVTFVSFYLLNCICIIFHAFSIHSRLFIRLVSEVLGAVFPNICPLLLIFRDPKDPFSVLFKC", "length": 307 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N2C2-1", "protein_name": "Predicted gene 2974", "gene_name": "Gm2974", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSWLLRLFQKENGDEGETRPTEKEEGILSHEKERRKWFWRRHRSARNTSTQNSKMTKKRSKINELEELKLDMRKISNDMEEMCGILNLYMYEDLNYRMNTEFNIIKSQHEKTMLDMNKMIQSIIGSMQYSKELIEDNYSYSIKEDHLLRECTQLNENVRILLNENRRLLVEQAGHKCPVGKKRGSLRRPARTSVSQVPRNSSVI", "length": 205 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "L7N474-1", "protein_name": "Spermatogenesis associated glutamate (E)-rich protein 1E", "gene_name": "Speer1e", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "ARRHTSSTAPDLSKKEFKKEKERLTTELHLLIQLRNEQRDHLIDFKESSNYNRTKPTQKKNPFYEQLRSTKNQVLSSVHKLEMGIIEAQENIQELNKWIDYFTNLHSQLLMEKNLKMSITQNQKNKEVEIDWALIEKYLVDVNLNGRTGADQQP", "length": 154 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "M0QWR4-1", "protein_name": "Aly/REF export factor family member 14", "gene_name": "Alyreffm17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADKMDMSLEDIIKLTKIQQRRHDRPDSRVNRGTGSKRYRPAFTHGGRNRLAPYCRPKQLPDKWQHDLFIGGFRGQNHVDTGGKLFLSNLHFGVSDADIQLLFAEFGTLKKSAVHYDRCGRSLGTAQVHFERKADALKAMREYNGAPLDGRPMNIQLATSQIDRQGRPAQSKNRGGMTRNPGSGVLSGGGTKKWTLGGSQGRGRGTIRNSKLQQQQQQQKQKQQQQQQKQQQKQQQKQQQQLSAEELDAQLDAYQEMMDTS", "length": 261 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "M0R3T3-1", "protein_name": "Peptidase S1 domain-containing protein", "gene_name": "ENSRNOG00000067174", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRFLVLCLILSLGDYGAFPLIQSRIHRGCKGERHSQPWQVAMYHYDKAVGWGWHPSPTTMSTSPSHNKVRLGQHSLDADGDTGQDVPVRHSIPHPLYNRSLQMPTFLSPDADNSHNLMLRQLREPANTTEAVRVTEEPTEEAKLGSRCLASGWGSTRPDKCMPGMLQCVDLTLMSSDVCTYAYSQRVTESMLCAGHQEGSRDTCMGDSGTTLICDRMLQGITSWGGNPCA", "length": 230 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0R777-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "Smokwl5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASKSKEKTLGSHYKILSYLGQGSFGTVNLAWHLKTQALVAIKMLEISKETISSILSERAILETLHHPNIIRLFQVLITSSHVNFVLEYAPGGSLFELIKEGGPLQEEVAKKIFGQTVSAVKYCHNLDIVHRDIKPQNILTDAEGNGKLTDFGLATKFRPGTLLKELCGTKEFYAPELVLREPYNGKKTDVWSLGVLLYFISTGYCPFRGVTTKDMEKKIATGTYTIPTYFSGQLENLIHQILTVSPEMRPSIEDIEKHPWVRKCEVNIPTITCPDYKIVEMLCGMGYNANKILESLQKKKYDEPMAAYLILKDKVRQEIEHGTTTSDMPVDQGPLPPQSPAHHSVSGLPLKRRASEPNFGLLHIWPPGEQVARHNVARSVSMPPIALYGTKKQNSTSTSALHSRPVASPCVCNTILEIEIPLPTKQDFDMKTSSPPQRIGYFQRLCQRIRDCLSRLCCFLWAPKVHSPRKWLP", "length": 474 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0R9M1-1", "protein_name": "Olfactory receptor family 52 subfamily N member 1B", "gene_name": "Or52n1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLLNVSSLTPASLILNGIPGLEEVNLCIFFPLFTMYSIALTGNFGLIYLIYSEEVLHRPMYIFLALLSFTDVLMCTSTIPNTLFISWFNFKKIDFKACLAQMFFVHTFTGMESGVLVLMVLDLYIAMCYPLRYATILTNVVIAKAGMLTFLRGVALVIPFIFLTKRFPYCKGNVIPHTYCDHISVAKISCGNVQINAIYGLMVVLLIGDFDIPCITVSYTMILWAAVSLSSADARQKAFSTCTAHICAIVITYVPAFFTFFTHRFGWHTIPSHIHIIMANLYLLMPPTMNPIVYGVKTKQIQKRVIRFFFKGRENSSHKF", "length": 321 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0R9X6-1", "protein_name": "Paired immunoglobin-like type 2 receptor beta 1 like 2", "gene_name": "Pilrb2l4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALLVSLPEQNLAMAWILLLLLLAACLHTGNSAGYQKTQDYGVNQPEQLTGIQGGSIEIPFSFYFPWELAKDPQMSIAWRWKVFFGEVIYNSTLLFLHEHFKGRLIMNWTQGQTSGVLRILNLKANDQSTYFSRIFLQATEGMKLWQSRAGTKLIIHALSTTMASPSIIPSAVPTAGLENTRGQRNPSLLNLGAMVGMVMAKVVVIIPLYGWVIFLWWKQRLPTARISHQVSLHHTPCIPQSSMSSLWESELVAAGFSCESHSWITPTSAMGARIPSPWNQGPPVCLWA", "length": 289 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RAD6-1", "protein_name": "Olfactory receptor", "gene_name": "Or1f19f", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRSTNQSSVSEFLLLGLSRQPQQQQLLFLLFLIMYLATVLGNLLIILVISTDSHLHTPMYFFLSNLSFVDVCFSSTTVPKVLANHILSSQAISFSGCLTQLYFLCVSVNMDNFLLAVMAYDRFVAICHPLYYTTKMTHQLCVLMVSGSWVTASLNALLHTLLMARLSFCGDNIIHHFFCDVTPLLKLSCTATNLNELMILTEGAVIMVTPFVCILISYIYITNAVLRVSSFRGGWKAFSTCGSHLAVVCLFYGTIIAVYFNPVSSHSSEKDTAATVLYTVVTPMLNPFIYSLRNNDLKGALRKVVHRKI", "length": 309 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RBH5-1", "protein_name": "Surfactant associated 2", "gene_name": "Sfta2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPSMCLFLLLTLLCSSLAGPTKVTLQVKLTEASQAKTSQDSGFLDMLQKICLLLHLSPGTNVTLHHKGPPHHLTCRA", "length": 78 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RCJ6-1", "protein_name": "EF-hand domain-containing protein", "gene_name": "AABR07013776.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADQLTEEQIAEFKEAFPLFDRDGDQTVTTKELGMVMGSLGQNPTEAELQDMISEVDADGNGTINFPEFLTMMARKMKGTDVEEEIREAFRVFDKDGYTSAAEFRHVMTTLGEKLTDEEVDGMIREADMDGDGQVIYEEFVQMVTAK", "length": 147 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RCP1-1", "protein_name": "Leukocyte immunoglobulin like receptor B3", "gene_name": "Lilrb3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVSTLTALAYLGLILGSENPVLSGAFTKPTIKMVPSNVVTTGKQVTIFCEGSSHAKEYRLHKEGSPDYLTPTTFLETENKAKFSISPIQWNNAGQYWCSYRSLTNKLRQSDIMELVVTGVILGEVTLSALPSYVVTSGRNVTLQCASQVVYDRFILMKEDEKFSTAMPSWKIYPVLWGAIFTLGPVTSNQRWRFTCYGYYLSSSLIWSKPSNHLELLVSGTLHKPILWAHPGSMVTSGSPVTIWCEGDQETQTYVLYRQGSLESWNRQTQKDYNNKAEFTIPSVTYLNAGHYFCYSYTSAGWSEHSDTLELVVTGVYKKPIFLALKNPIVNLGVTVTISCTSNQSFNCFLLMDDDQKIYRFFDLQYSYSGESLARFQVGPITSRQRWRFRCYGYYTDNPQVWSEASDPLDFLVSGNLQKPTLWAEPGSVIESGNSVTIWCEGTMETQIYFLYKEGSPSSWLRQTPKEPGNKAMFFIAFMEKHNAGQYRCYCYNFGGWSQHSDTLELVMTGVHHGKPTLSAFPSPMVTSGGNVTLYCASSTIYDWYIVTGQDLKFSRFQRAQFIPTEMSQALFSEISVASRKKGPFRCYGFNESTPHLWSEASNPLEIHVSGVSRKPSLLNQQGPVLAPGENLTLRCSSELSYDRFSLSKEGRSDLPQLSVSQSQTGEYYANFFLYSVDFSIAGQYRCYGASRFSSEWSAPSVPQDILVTGHPPITPSLSVNPGTIVSSGENVTLLCQSSIPMDTFFLFKKGDAYPYMHQRLKFQGPQCKAEFSLSAVTPNIGGIFTCFGSQSSSPYLLSHPSVPVEIKVSGLAKYQKSLIWVSVVFFLLFFVLTLFFFLRLWHQNKHRKGVQTKIDLQHPEGAVEPKSIVGHLQKSSRPAPAIQEEILCEKRWPGREITEVSASDATVKVTRSADNVELGILSQHQDDPSIHLYAQVKPARLRRAQTTSSSLFPKELQHSKHRQKNRDQVIDQQADTSQDSHAVIYAQLHIMTPRQGRQTSLFPGRIC", "length": 1008 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RCQ2-1", "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "LOC100361204", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSSIPDPEADLIQLNGSYHTETSPCVIESRVMILLSIIIAFFGLAGNAMVLWLLAFRMRRNVFSVYILNLAGANFLFLCTHTAFSLEKIIVLFHSVHIHIPLLFYTLSTLAYLAGVSMVTAISAEYWLSGIWPYWYQGQRLKHTTTVICTGLWGLALLLSLLEGKSCGFLGSTYNQDVCWKLDFIIVAWLLVLFAVLSRSIQVLLVRIFCGSQRTPVTKLHVTIVLTALVLVICGFPFGIIFYLLYWTTEVYYIMPCNSFHETILLLSYINSCANPIICLLVGSIRHCRFQCGTLRLLLHRAMQDIPEEEGEELEEVVGERVQSSIP", "length": 328 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RCW7-1", "protein_name": "Uncharacterized protein", "gene_name": "Pilrb1l3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALLVSLPEQNLAMAQLLLLLLSAACLHTGNSAGYPKKNVFSVDQPAVLSGVQGGSIEISFSFYFPWELAKVPQMSIAWRWKNYHGEYIYNSTQPFIHEHFKGRLIVNWSQGQTSGVLRILNLKENDKATYFSRVFLPTTEGMKSWQSVAGTQLIIIHAPSTTVVSPSIIPSVVPIAGLEDTRGKRTPSLLNLGAMVRMVVSKVVVIIALYGWVIFLWWKQRSAWSLLSFLTTWKSEEQMQMNTAPAPKEFK", "length": 252 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RCY4-1", "protein_name": "Retinoic acid early-inducible protein 1 domain-containing protein", "gene_name": "AABR07000137.1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSAPLGSLGRKSKNQSLGLDMLGTVLSTDSLSCTFTVKYRSSPGQCSVNGKPLLLFNDERQNSPVGKPEKKGNATKVCAELNQSLKDIFQKMMNLESWLFESKGNHTLQVTVQSQYNQGIFMDGCWVFTIDRQYPFYFYPKIMTWRESHPDASRTVSQWQNNRQVAQSLRTCSMGDFSQCLRKLLTDSREVPRSTITTLDPTQPSSAIQIPPTVDSASSVFTTWSQYIFVLILCLAILIINALIP", "length": 246 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RD07-1", "protein_name": "Uncharacterized protein", "gene_name": "ENSRNOG00000064269", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRMMAMQMMTNSISDAMERYKELIQVNSSYNIRQSQLLREQAQLKNNIQILLNEKRELLVEETELPASSVEAKRLCEEAGMNICDPRAKQQQV", "length": 93 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M0RDP5-1", "protein_name": "Zinc finger protein 353", "gene_name": "Zfp353", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDVAETPGASQTVPCNTQPSPVESSQLVSGQSSEMPTWKKTVMASACCNPQETACTQNSTAHPGKASDFYFGEPSETASFIQQVVSAEQKSSPAGSCLMNLSSTTKSCLSHPLKTEVLDTRKTLCNEGHWGRTLNSDKTLLIQITTMYESQWRTLGNHPVAPSGYHEGQAPNMDHLVDSVSNQTFIGDLEMEPSCNHVLYTDQFITSFSEQNPFGDQQRSPVADNRFYADQKILPNGYQTFYEPQMSTNYQITCVCGQNVCRCQEILLSGEHLLSEYQTSGYRYDQDLIVNLQVTSPIGGEPLHDSQIPNSNFDTTSCGTKRTTSSEEDNLAWHPETSLSSEETFLDQMRTSVDQNVYPSHNGTLKIEESLEPQVTSLSNQAPYVGESSDTSNSPLIQIQPQEISSASGLDQGQHPEIKLDLKTQSPVSLKNPHNSKRYCCTYQGCKKSYKKSQHLKDHMKKHTGVKPYMCNKPGCDWKFFRLVDLNRHKQKHSGERPYPCPMCNKNYSRFYYLKQHLRSHIQASPTTAT", "length": 530 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M9MSI7-1", "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG42818", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFIHQREQLPFKHNEQDPNYLAPVIQKRKPMDKDPRNPLKRLKFLQEFPTQSSKGDLDDLKYPTQLEGRHDSPKYDKTFHTEIHANNETDSQELENIILEKNLQDSKTEFQENRASQPKNMHSFQIPEAIESHFNNKELQNENDLHKGLKQQYRSGSEQDKSGPENVREIASKLILQWAENQRSLLDSFVKAITDVLKVHDSKLNMKINISPRDIMILKDMLKQLLESIMQLREGSTSTRARIVLNKWIETQKSLIDSFSQAIQNTNQNVDNIANVYEVMENLNKNLRELVILLSDKESFPTTESSSSQQTTSIYATTTFYLTSSTFGSTHPIVDENINRVNIMGNLIKGLRNIMVQMDETNKTSSSTSYTTTESTYIQPSTSTYLNAEVTTSHPTTSTYEVTNIITDESKIKDMFNLIKGIEDLISQYNGKHKFTSTTSLTGKSNSREPTMTTYSSAGGITSHSFTTTSPKTVTTSSSHSTTESSPSHPTTSNYEVTVFDQDSHKFKVMKNLIKELKGLIEHFSDTKNITSTTYSTGDSKSFQPTATTPDSTDRSSSQPITFPESTTSTTNLQSTITNHLSTESTSSQLNTTLSITGTTTPNLTTSTHDFKDQINDDDSKSLKHLIKILSDLVYSLNDKNNIKSTSQLTTESTFNSSINITNSTTVASSTFSTTESMAIHSTPYLSTREITVFQFNDVENINPIISNNSTTVTTNIHSSTYTTSTTDNTTSYPNLSTTESSPTFDSTISHSNTSSQTRSLGSYKDKIKNIVELLKKLRKIQKTLADKSKGQLSPMLISRIKAVLKQIVAGNIDSVNGDSTELEILLSTTVNPNEDTTDLTMEKLLKLFDDFERMYNVLLDDSIQSTTQSTTQNNTIFSTTYSTIFSTTQSISTTSPTQYALTSSTPNTSTTSHSSTPSSINNLRSDESNNHQPIVDAIQQLKMALYHDFYAFKKSQEERMEKILQLLNGKPIDRRTKTIAKPRTIRKKVSREIQKRNSDVKEDKIHHYKADKFIKNPKNGNQDSHIPKPILNSARSKIKDVPLKLSAIKVNGGLKHLPSKRKANEEVSAMHEIFPEPVSILPHK", "length": 1085 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "O08640-1", "protein_name": "Keratin-associated protein 14", "gene_name": "Krtap14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSCNSCSGTFSQSFGGQLQYPISSCGSSYPNNVFYSTDLQTPITHQLGSSLHSGCQETFCEPTNCQTAYVVSRPCQRPFYSQRIRGPCRPCQSTFSGSLGFGSRGFQSFGCGYPSQGFGSHGFQSVGCGTPTFSSLNCGSSFYRPTCFSTKSCQSVSYQPTCGTGFF", "length": 167 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O21032-1", "protein_name": "Large ribosomal subunit protein uL16m", "gene_name": "mrpl16", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKIPNRQKFTKNHKRNLITKETRKTGLVLGNYGIKATETGYLKMKQMERIKGDLVKKLKDNMDIYFNFYPLFGLTNKGTARMGAGKGEVSEWYVLVKKGSIVVEFIKSRMTAGAMQKVIRYSANKWPIKVRMTQIKQGLYEKKI", "length": 144 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "O21042-1", "protein_name": "Cytochrome c oxidase subunit 1+2", "gene_name": "2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKILEIYDKQIAEKEGNIFIFISKWIISVDHKNIGTMYTNFSILAGIVGTLLSLVIRMELSTGNMLDGDGQQYNVIVTAHGLIMIFFVVMPAMLGGFANWFIPIMVGSPDVAFPRLNNISLWLIIVSFFLLLTSSCVGIGVGTGWTVYPPLSTMEYHPGHAVDVGILSLHIAGASSLLGAINFLTTVFNMKIAGLSWSKVSLFVWSILITAVLLVLSLPVLAGGLTMLITDRNFETTFFDPIGGGDPILYQHLFWFFGHPEVYILILPGFGLVSIILSKYSNKGIFGVKGMISAMSAIGFLGFLVWAHHMYTVGLDVDTRAYFTAATMIIAIPTGIKIFSWLATLWGGVIKITTPMLFVIGFLVLFTIGGLTGVVLANGGLDISLHDTYYVVAHFHYVLSMGAIFAIFAGYYYYYSIMNSTRLFGVVRYNEQLGRIHFWTMFIGVNVTFFPMHFLGLAGMPRRIGDYPDAYIGWNLIASYGSLITAFGLLFFVVNIFTPYIRRSVNIKNGAIILMGLDFARDWQIGFQDPATPIMEGIIDLHNYIFFYLIVVAVFIGWVMGRILWRFSYKWSYPTIGDIEIFKNFTAYNQIIHGTVIEIVWTLIPTVILYLIAIPSFTLLYAMDEIINPTVTIKIIGHQWYWSYEYGDNASNLIEFDSYMVYERDLAEGQLRLLEVDNAMVVPVKTHIRLIITSGDVLHSWAIPSFGIKVDAVPGRLNQIGLYVKREGTFYGQCSELCGVDHGFMPIKVQAVKLGEYFSKLNEK", "length": 764 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "O21049-1", "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "cox3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKGFFENLFRQNVRSVINTGKKVGARAAAREIINQEWGYPLANHEVLFLTNVYQPKHMKRHPFHIVRGTVAPLAVTLPLGFFVLNYFGVISSKLGLLIALSSFIGGLVIWTISIIFDSLYDQQHTYEVKRGLVMGMMMFIISEVMFFFSFFWSYFYISLSPNIAIGCVWPPYGLTVYSYMGLPLLNTVLLLLSGAILTDGYTILTEQKAVHEKNEKVLAVEEAFKNLMNLYKTKNSINTLTFVDERRDKFFGKESRQEDKIAEQKLIAISAGVKELRDLDWDLYFFENPENIEPNYKEPTNLSVIEYALITIYLKKRNKVIKTRLYFTLLCAVVFLACQGYEYFFAPFSMNDGIYGSLFFLLTGFHGFHVLVGSILIGIITIRFIVGNFNLLNVGTNFQIYKNKSTGFACTLFYWHFVDIVWIFLYIVIYWWGSR", "length": 435 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "O23373-1", "protein_name": "Formin-like protein 3", "gene_name": "FH3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGRLRLAFLAISLVVFVCVSEEIFSRGGLNLLRFSVYGEDVAEQTWIHQNPRRKLISYPKKFSVSAPNLAFGPAPSFAPGPGPSFAPGPAPNPRSYDWLAPASSPNEPPAETPDESSPSPSEETPSVVAPSQSVPGPPRPPPQREKKDDILMKLIIAVASTAVLTFVFVALMFLCCFKRNCNNAVGSRDGPRDEGPLLRLSTGSTENSPTVASTSRKMFSVASSKKRSFLSRVSLKRNGHEFSTAESSSAAGLPPLKLPPGRSAPPPPPAAAPPPQPPPPPPPKPQPPPPPKIARPPPAPPKGAAPKRQGNTSSGDASDVDSETGAPKTKLKPFFWDKMANPDQKMVWHEISAGSFQFNEEAMESLFGYNDGNKNKNGQKSTDSSLRESPLQYIQIIDTRKAQNLSILLRALNVTTEEVVDAIKEGNELPVELLQTLLKMAPTSEEELKLRLYSGDLHLLGPAERFLKILVDIPFAFKRIESLLFMISLQEEVSGLKEALGTLEVACKKLRNSRLFLKLLEAVLKTGNRMNVGTFRGDAQAFKLDTLLKLSDVKGTDGKTTLLHFVVLEIIRSEGVRALRLQSRSFSSVKTDDSNADSSPQSVERYRSTGLQVVTGLTTELEDVKRAAIIDADGLAATLANISGSLTNAREFLKTMDEESDFERALAGFIERADADFKWLKEEEERIMVLVKSSADYFHGKSAKNEGLRLFAIVRDFLIMLEKVCREVKETTKTTNHSGKKESEMTTSDSNQPSPDFRQRLFPAIAERRMDSSDDSDDEEDSSPS", "length": 785 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O35698-1", "protein_name": "RNA-binding motif protein, Y chromosome", "gene_name": "Rbmy", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAETNQPGKIFIGGLNIKTRQKTLQEIFGRFGPVARVILMRDRETKKSRGFAFLTFRRLADAKNAVKEMNGVILDGKRIKVKQARRPSSLESGSKKRPPSFSRTRGASRILKCGRGGRSRARSGPSCEGNLGGDRYTPNFNVSSSGRHFAVKRNPSSKRDDPPSKRSATSAQTRSNTGLRGREPHRREISRNMPRGEPASSRRDEYPLPRDYGQSSNDRKYESTSRGYCDYGNYHSREESASKVFSDHAGYLGGRDRDFSEYLSGNSYRDTYRSYGRFHEAPSARGGNNRYDDYSNSQDGYGGRGEPYISNRSNIYSSDYERSGRQEVLPPPIDREYFDREGRQERGHSPKDGLYSASRESYSSNTKIWGIPWRSWRKQI", "length": 380 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O60309-1", "protein_name": "Leucine-rich repeat-containing protein 37A3", "gene_name": "LRRC37A3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSAQCPALACVMSPLRFWGPWPLLMWQLLWLLVKEAQPLEWVKDPLQLTSNPLGPPEPWSSHSSHFPRESPHAPTLPADPWDFDHLGPSASSEMPAPPQESTENLVPFLDTWDSAGELPLEPEQFLASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSLAEIIGIIHQLSTPQSQKQTLQNEYSSTDTPYPGSLPPELRVKSDEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPPESSMESLTLPNHEVSVQPPGEDQAYYHLPNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPSESSREVESSPTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLGFTITPESMTEVELSPTMKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSHLTRATVQPLDLGFTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSPTTEETSTQLPDLGLAIIPEPTTETGHSTALEKTTAPRPDRVQTLHRSLTEVTGPPTELEPAQDSLVQSESYTQNKALTAPEEHKASTSTNICELCTCGDEMLSCIDLNPEQRLRQVPVPEPNTHNGTFTILNFQGNYISYIDGNVWKAYSWTEKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFQAWHGMQFLHKLILNHNPLTTVEDPYLFKLPALKYLDMGTTLVPLTTLKNILMMTVELEKLIVPSHMACCLCQFKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFMKVLQARKNYTSTELIIEPEEPSDSSGINLSGFGSEQLDTNDESDVTSTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGKNRQRLNRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENTAEEKRLGSPAPRELKQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGAPSTSSPAKALPQVRDRWKDLTHAISILESAKARVTNMKTSKPIVHSRKKYRFHKTRSRMTHRTPKVKKSPKVRKKSYLSRLMLSNRLPFSAAKSLINSPSQGAFSSLRDLSPQENPFLEVSAPSEHFIENNNTKDTTARNAFEENVFMENTNMPEGTISENTNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSVIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLVSRTGHLMKLLSGQQEVKASKIEWDTDQWKTENYINESTEAQSEQKEKSLEFTKELPGYGYTKKLILALIVTGILTILIILLCLIEICCHRRSLQEDEEGFSRDSEAPTEEESEALP", "length": 1634 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O80489-1", "protein_name": "small monomeric GTPase", "gene_name": "SARA1A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MFLFDWFYGILASLGLCKKEAKILFLGLDNAGKTTLLHMLKDERLVQHQPTQHPTSEELSIGKINFKAFDLGGHQIARRVWKDCYAKVDAVVYLVDAYDRDRFVESKRELDALLSDEALANVPCLILGNKIDIPYASSEDELRYYLGLTNFTTGKGIVNLEDSGVRPLEVFMCSIVRKMGYGEGFKWLSQYIK", "length": 193 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O80614-1", "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSSDMRDERFFYHRYLSVTNRTTPTTATNLPTSTSNMRSTSLMTPRVAHTSMSSGGDFPDDRFFHARHQSATDRAASNRSRAIMPISTTNVPSSTSNSPRVLQTSMSRRGTSPMSSSTRRSVQASMSARETVPSSTSTRSMQTSTSTPEIMPTSSRNVITSSEEVANTFTQTSYIQFGSLWETNTTPSTRSWPTVPSSNSPRVLQTSMSRRGTSPMSSSTRRNVQSSMSGRETVSSSTSTSSMQTSMSTPEIMPTSSRNVITRSEEVANTFSTQTPYIQFGRLWETNTTSSTRSRTTVPTSTTNVPSSNSSRVLQTSMSTRGTFPMSSSTRMSVQASMLAPGTVSSSMSTVEIMPTSARNMITMSEEVANSFTQTSYIQFGSLWETFKTVTKLSRVAMVENGECVICLEEWRKETYVTSSTSNMRTSSLMTLTRFIDEQISLRATVSSTRTTARLLTNESPATIRAVAMLPRVAMVEKGECVICFEEWSKSDMETELPCKHKYHLECVEKWLKIHTSCPQCRYKLSCVYKSFLML", "length": 535 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "O81153-1", "protein_name": "Proteasome subunit beta type-3-B", "gene_name": "PBC2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSIFEYNGSAVVAMVGKNCFAIASDRRLGVQLQTIATDFQRISKIHDHLFIGLSGLATDVQTLYQRLVFRHKLYQLREERDMKPETFASLVSAILYEKRFGPFLCQPVIAGLGDDNKPFICTMDSIGAKELAKDFVVSGTASESLYGACEAMFKPDMEAEELFETISQALLSSVDRDCLSGWGGHVYVVTPKEVKERILKGRMD", "length": 204 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P00757-1", "protein_name": "Kallikrein 1-related peptidase-like b4", "gene_name": "Klk1b4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSQVDCENSQPWHVAVYRFNKYQCGGVLLDRNWVLTAAHCYNDKYQVWLGKNNFLEDEPSDQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLSKPADITDVVKPITLPTEEPKLGSTCLASGWGSTTPIKFKYPDDLQCVNLKLLPNEDCDKAHEMKVTDAMLCAGEMDGGSYTCEHDSGGPLICDGILQGITSWGPEPCGEPTEPSVYTKLIKFSSWIRETMANNP", "length": 256 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P01241-1", "protein_name": "Somatotropin", "gene_name": "GH1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF", "length": 217 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P02762-1", "protein_name": "Major urinary protein 6", "gene_name": "Mup6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNANRCLQARE", "length": 180 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P04071-1", "protein_name": "Kallikrein 1-related peptidase b16", "gene_name": "Klk1b16", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWFLILFLALSLGGIDAAPPVQSRIVGGFKCEKNSQPWQVAVYYHKEHICGGVLLDRNWVLTAAHCYVDECEVWLGKNQLFQEEPSAQNRLVSKSFPHPGFNMTLLTFEKLPPGADFSNDLMLLRLSKPADITDVVKPIDLPTKEPKLDSTCLVSGWGSITPTKWQKPDDLQCMFTKLLPNENCAKAYLLKVTDVMLCTIEMGEDKGPCVGDSGGPLICDGVLQGTVSIGPDPCGIPGVSAIYTNLVKFNSWIKDTMMKNA", "length": 261 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P04644-1", "protein_name": "Small ribosomal subunit protein eS17", "gene_name": "Rps17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKNLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGAV", "length": 135 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P05817-1", "protein_name": "Prestalk D11 protein", "gene_name": "ampA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLNKLILLLILSSCLVLSVKSEVNVDCSLVRCAQPICKPHYRLNMTDSCCGRCEPCTDVACTLQVKYCQDGEVPTGCCPCTLPPTKPDCSLVKCARPVCKPYYRLNMTDSCCGRCEPCTGVACTLQIKYCKDGEVPTGCCPCTPQPTKKPDCSKVPCPKILKYCQEGELPTGCCPCTPQPTKKPDCSRVPCPKILKYCKEGELPTGCCPCTPQPTKKPDCSDVMCTMDIRYCKNGELPTGCCPCTPQETKVPDCSKAMCTMDIKYCKPGEKPFGCCPCRENLTQ", "length": 284 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "P06325-1", "protein_name": "T-cell receptor gamma chain V region 5/10-13", "gene_name": "Tcrg-V1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLLRWPTFCCLWVFGLGQLEQTELSVTRATDESAQISCIVSLPYFSNTAIHWYRQKAKKFEYLIYVSTNYNQRPLGGKNKKIEASKDFQTSTSTLKINYLKKEDEATYYCAVCRSGTSWVKIFAKGTKLVVIPP", "length": 135 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P06349-1", "protein_name": "Histone H1t", "gene_name": "H1-6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSETAPAASSTLVPAPVEKPATKRRGKKPGMATARKPRGFSVSKLIPEALSMSQERAGMSLAALKKALAAAGYDVEKNNSRIKLALKRLVNKGVLVQTKGTGASGSFKLSKKAASGNDKGKGKKSASAKAKKLGLSRASRSPKSSKTKVVKKPKATPTKGSGSRRKTKGAKGLQQRKSPAKARATNSNSGKSKMVMQKTDLRKAAGRK", "length": 208 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P07628-1", "protein_name": "Kallikrein 1-related peptidase b8", "gene_name": "Klk1b8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRFLILFLALSLGGIDAAPPLQSRVVGGFNCEKNSQPWQVAVYDNKEHICGGVLLERNWVLTAAHCYVDQYEVWLGKNKLFQEEPSAQHRLVSKSFPHPGFNMSLLTLKEIPPGADFSNDLMLLRLSKPADITDAVKPITLPTKESKLGSTCLASGWGSITPTKWQKPDDLQCVFLKLLPIKNCIENHNVKVTDVMLCAGEMSGGKNICKGDSGGPLICDSVLQGITSTGPIPCGKPGVPAMYTNLIKFNSWIKDTMTKNS", "length": 261 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P07647-1", "protein_name": "Submandibular glandular kallikrein-9", "gene_name": "Klk9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWFLILFLALSLGQIDAAPPGQSRVVGGYNCETNSQPWQVAVIGTTFCGGVLIDPSWVITAAHCYSKNYRVLLGRNNLVKDEPFAQRRLVSQSFQHPDYIPVFMRNHTRQRAYDHNNDLMLLHLSKPADITGGVKVIDLPTEEPKVGSICLASGWGMTNPSEMKLSHDLQCVNIHLLSNEKCIETYKNIETDVTLCAGEMDGGKDTCTGDSGGPLICDGVLQGLTSGGATPCAKPKTPAIYAKLIKFTSWIKKVMKENP", "length": 259 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P08932-1", "protein_name": "T-kininogen 2", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKLITILLLCSRLLPSLAQEEGAQEMDCNDETVFQAVDTALKKYNAELESGNQFLLYRVTEGTKKDGAETLYSFKYQIKEGNCSVQSGLTWQDCDFKDAEEAATGECTTTLGKKENKFSVATQICNITPGKGPKKTEEDLCVGCFQPIPMDSSDLKPVLKHAVEHFNNNTKHTHLFALTEVKSAHSQVVAGMNYKIIYSIVQTNCSKEDFPFLREDCVPLPYGDHGECRGHTYVDIHNTIAGFSQSCDLYPGDDLFSLLPKKCFGCPKNIPVDSPELKEALGHSIAQLNAQHNHLFYFKIDTVKKATSQVVAGTKYVIEFIARETNCSKQTNTELTADCETKHLGQSLNCNANVYMRPWENKVVPTVRCQALDMMISRPPGFSPFRLVQVQETKEGTTRLLNSCEYKGRLSKAGAGPAPDHQAEASTVTP", "length": 430 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P0C0S7-1", "protein_name": "Histone H2A.Z", "gene_name": "H2az1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV", "length": 128 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P0C2B7-1", "protein_name": "Large ribosomal subunit protein mL52", "gene_name": "MRPL52", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MAALGMLLSTGVRRLHCGSAARAGSQWRLRQGLAANPSGYGPLTELPDWSYADGRPAPPMKGQLRRKAQREKFARRVVLLSQEMDAGLQAWQLRQQEKLQEEKRKQQNALKPKGVLLQNPGPSQ", "length": 124 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "P0C644-1", "protein_name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1", "gene_name": "Ppip5k1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWSLTANEDEDESATAHFFLGAGDEGLGTCGIGMRTGESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPPCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLTMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPACPEECNLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVTHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPGAEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASSEGQDLQREPPAPSLLLVLKWGGELTPDGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTGSTSLLNSMSVIQNPVKVCDQVFALIENLTHQIRERMQDPSSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKVEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETKDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGVEEGSAPAGCGFRPASSENEEMKTDPGSIENLCPAKPSDEPDRALQTSPQPVEGTGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARTHGKKLPPAGLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLTKVCQRHTDAHAQASAALFDSMHNHQASDNPFSPPRTLHSPPLQLRHRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSHFGFSDQSSVNTQMIEEKQGLGLLQETPGDGTPEFHIELAESTQSPQEPPVEISPPGSQDDTEVNQTCQEVPDTIQPCHDILEEIGQPNQEVPDISQLLLKNHDTATNTCQPCQASQLSKKVYEEICQLCQDNPEESNQLCQEVSVELGRMVHRFPVSIGSTTQETLMEIGRPTQEIPEEPCQEFSEKVGMLTQKASAISELSQDILETDNPSQELSEETDLQAQEVSEEIDQEPEVVDELSNEDIS", "length": 1434 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P0C7H9-1", "protein_name": "Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7", "gene_name": "USP17L7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDDSLYLGGDWQFNHFSKLTSSRLDAAFAEIQRTSLSEKSPLSSETRFDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQKIGNTFYVNVSLQCLTYTLPLSNYMLSREDSQTCHLHKCCMFCTMQAHITWALHSPGHVIQPSQVLAAGFHRGEQEDAHEFLMFTVDAMKKACLPGHKQLDHHSKDTTLIHQIFGAYWRSQIKYLHCHGVSDTFDPYLDIALDIQAAQSVKQALEQLVKPKELNGENAYHCGLCLQKAPASKTLTLPTSAKVLILVLKRFSDVTGNKLAKNVQYPKCRDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASGITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRPATQGELKRDHPCLQVPELDEHLVERATQESTLDHWKFPQEQNKTKPEFNVRKVEGTLPPNVLVIHQSKYKCGMKNHHPEQQSSLLNLSSTKPTDQESMNTGTLASLQGSTRRSKGNNKHSKRSLLVCQ", "length": 530 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0CW02-1", "protein_name": "Lymphocyte antigen 6C1", "gene_name": "Ly6c1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDTSHTTKSCVLILLVALLCAERAQGLQCYECYGVPIETSCPAVTCRASDGFCIAQNIELIEDSQRRKLKTRQCLSFCPAGVPIRDPNIRERTSCCSEDLCNAAVPTAGSTWTMAGVLLFSLSSVVLQTLL", "length": 131 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P0DKL4-1", "protein_name": "Spliceosome-associated protein 130 A", "gene_name": "SAP130A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MYLYSLTLQQATGIVCAINGNFSGGKTQEIAVARGKILDLLRPDENGKIQTIHSVEVFGAIRSLAQFRLTGAQKDYIVVGSDSGRIVILEYNKEKNVFDKVHQETFGKSGCRRIVPGQYVAVDPKGRAVMIGACEKQKLVYVLNRDTTARLTISSPLEAHKSHTICYSLCGVDCGFDNPIFAAIELDYSEADQDPTGQAASEAQKHLTFYELDLGLNHVSRKWSNPVDNGANMLVTVPGGADGPSGVLVCAENFVIYMNQGHPDVRAVIPRRTDLPAERGVLVVSAAVHKQKTMFFFLIQTEYGDVFKVTLDHNGDHVSELKVKYFDTIPVASSICVLKLGFLFSASEFGNHGLYQFQAIGEEPDVESSSSNLMETEEGFQPVFFQPRRLKNLVRIDQVESLMPLMDMKVLNIFEEETPQIFSLCGRGPRSSLRILRPGLAITEMAVSQLPGQPSAVWTVKKNVSDEFDAYIVVSFTNATLVLSIGEQVEEVNDSGFLDTTPSLAVSLIGDDSLMQVHPNGIRHIREDGRINEWRTPGKRSIVKVGYNRLQVVIALSGGELIYFEADMTGQLMEVEKHEMSGDVACLDIAPVPEGRKRSRFLAVGSYDNTVRILSLDPDDCLQILSVQSVSSAPESLLFLEVQASIGGDDGADHPANLFLNSGLQNGVLFRTVVDMVTGQLSDSRSRFLGLKPPKLFSISVRGRSAMLCLSSRPWLGYIHRGHFHLTPLSYETLEFAAPFSSDQCAEGVVSVAGDALRIFMIDRLGETFNETVVPLRYTPRKFVLHPKRKLLVIIESDQGAFTAEEREAARKECFEAGGVGENGNGNADQMENGADDEDKEDPLSDEQYGYPKAESEKWVSCIRVLDPKTATTTCLLELQDNEAAYSVCTVNFHDKEYGTLLAVGTVKGMQFWPKKNLVAGFIHIYRFVEDGKSLELLHKTQVEGVPLALCQFQGRLLAGIGPVLRLYDLGKKRLLRKCENKLFPNTIISIQTYRDRIYVGDIQESFHYCKYRRDENQLYIFADDCVPRWLTASHHVDFDTMAGADKFGNVYFVRLPQDLSEEIEEDPTGGKIKWEQGKLNGAPNKVDEIVQFHVGDVVTCLQKASMIPGGSESIMYGTVMGSIGALHAFTSRDDVDFFSHLEMHMRQEYPPLCGRDHMAYRSAYFPVKDVIDGDLCEQFPTLPMDLQRKIADELDRTPAEILKKLEDARNKII", "length": 1214 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P0DKL6-1", "protein_name": "Spliceosome-associated protein 130 B", "gene_name": "SAP130B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MYLYSLTLQQATGIVCAINGNFSGGKTQEIAVARGKILDLLRPDENGKIQTIHSVEVFGAIRSLAQFRLTGAQKDYIVVGSDSGRIVILEYNKEKNVFDKVHQETFGKSGCRRIVPGQYVAVDPKGRAVMIGACEKQKLVYVLNRDTTARLTISSPLEAHKSHTICYSLCGVDCGFDNPIFAAIELDYSEADQDPTGQAASEAQKHLTFYELDLGLNHVSRKWSNPVDNGANMLVTVPGGADGPSGVLVCAENFVIYMNQGHPDVRAVIPRRTDLPAERGVLVVSAAVHKQKTMFFFLIQTEYGDVFKVTLDHNGDHVSELKVKYFDTIPVASSICVLKLGFLFSASEFGNHGLYQFQAIGEEPDVESSSSNLMETEEGFQPVFFQPRRLKNLVRIDQVESLMPLMDMKVLNIFEEETPQIFSLCGRGPRSSLRILRPGLAITEMAVSQLPGQPSAVWTVKKNVSDEFDAYIVVSFTNATLVLSIGEQVEEVNDSGFLDTTPSLAVSLIGDDSLMQVHPNGIRHIREDGRINEWRTPGKRSIVKVGYNRLQVVIALSGGELIYFEADMTGQLMEVEKHEMSGDVACLDIAPVPEGRKRSRFLAVGSYDNTVRILSLDPDDCLQILSVQSVSSAPESLLFLEVQASIGGDDGADHPANLFLNSGLQNGVLFRTVVDMVTGQLSDSRSRFLGLKPPKLFSISVRGRSAMLCLSSRPWLGYIHRGHFHLTPLSYETLEFAAPFSSDQCAEGVVSVAGDALRIFMIDRLGETFNETVVPLRYTPRKFVLHPKRKLLVIIESDQGAFTAEEREAARKECFEAGGVGENGNGNADQMENGADDEDKEDPLSDEQYGYPKAESEKWVSCIRVLDPKTATTTCLLELQDNEAAYSVCTVNFHDKEYGTLLAVGTVKGMQFWPKKNLVAGFIHIYRFVEDGKSLELLHKTQVEGVPLALCQFQGRLLAGIGPVLRLYDLGKKRLLRKCENKLFPNTIISIQTYRDRIYVGDIQESFHYCKYRRDENQLYIFADDCVPRWLTASHHVDFDTMAGADKFGNVYFVRLPQDLSEEIEEDPTGGKIKWEQGKLNGAPNKVDEIVQFHVGDVVTCLQKASMIPGGSESIMYGTVMGSIGALHAFTSRDDVDFFSHLEMHMRQEYPPLCGRDHMAYRSAYFPVKDVIDGDLCEQFPTLPMDLQRKIADELDRTPAEILKKLEDARNKII", "length": 1214 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P0DML3-1", "protein_name": "Chorionic somatomammotropin hormone 2", "gene_name": "CSH2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEETYIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLRSMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHDALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF", "length": 217 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DMV2-1", "protein_name": "Cancer/testis antigen family 45 member A9", "gene_name": "CT45A9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTDKTEKVAVDPETVFKRPRECDSPSYQKRQRMALLARKQGAGDSLIAGSAMSKEKKLMTGHAIPPSQLDSQIDDFTGFSKDRMMQKPGSNAPVGGNVTSSFSGDDLECRETAFSPKSQQEINADIKRQLVKELRCVGQKYEKIFEMLEGVQGPTAVRKRFFESIIKEAARCMRRDFVKHLKKKLKRMI", "length": 189 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DOV1-1", "protein_name": "Interferon-activable protein 211", "gene_name": "Ifi211", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVNEYKRIVLLRGLECINKHYFSLFKSLLARDLNLERDNQEQYTTIQIANMMEEKFPADSGLGKLIEFCEEVPALRKRAEILKKERSEVTGETSLEKNGQEAGPATPTSTTSHMLASERGETSATQEETSTAQAGTSTAQAGTSTAQAGTSTAQKRKSMREEETGVKKSKAAKEPDQPPCCEEPTAMCQSPILHSSSSASSNILSAKNQKSQPQNQNIPRGAVLHSEPLTVMVLTATDPFEYESPEHEVKNMFHATVATVSQYFHVKVFNIDLKEKFTKNNFITISNYFESKGILEINETSSVLEAAPKQMIEVPNCITRNANASPKICDIQKGTSGTVFYGVFTLHKKKVKTQNTSYEIKDGSGSIEVVGSGQWHNINCKEGDKLHLFCFHLKRERGQPKLVCGDHSFVKVTKAGKKKEASTVQ", "length": 425 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P0DTA3-1", "protein_name": "Speedy protein E11", "gene_name": "SPDYE11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQILGKIMMSHQPQPQEERSPQRSTSGYPLQEVVDDEVSGPSAPGVDPSPPRRSLGWKRKRECLDESDDEPEKELAPEPEETWVAETLCGLKMKAKRRRVSLVLPEYYEAFNRLLEDPVIKRLLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEAPKQNIFYFLYEETRSHIPLLSELWFQLCRYMNPRARKNCSQIALFRKYRFHFFCSMRCRAWVSLEELEEIQAYDPEHWVWARDRAHLS", "length": 265 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DUD3-1", "protein_name": "Speedy protein E14", "gene_name": "SPDYE14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQILGKIMMSHQPQPQEERSPQRSTSGYPLQEVVDDEVLGPSAPGVDPSPPRRSLGWKRKRECLDESDDEPEKELAPEPEETWVAETLCGLKMKAKRRRVSLVLPEYYEAFNRLLEDPVIKRLLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEAPKQNIFYFLYEETRSHIPLLSELWFQLCRYMNPRARKNCSQIALFRKYRFHFFCSMRCRAWVSLEELEEIQAYDPEHWVWARDRAHLS", "length": 265 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DUD4-1", "protein_name": "Speedy protein E15", "gene_name": "SPDYE15", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQILGKIMMSHQPQPQEERSPQRSTSGYPLQEVVDDEVLGPSAPGVDPSPPRRSLGWKRKRECLDESDDEPEKELAPEPEETWVAETLCGLKMKAKRRRVSLVLPEYYEAFNRLLEDPVIKRLLAWDKDLRVSDKYLLAMVIAYFSRAGLPSWQYQRIHFFLALYLANDMEEDDEAPKQNIFYFLYEETRSHIPLLSELWFQLCRYMNPRARKNCSQIALFRKYRFHFFCSMRCRAWVSLEELEEIQAYDPEHWVWARDRAHLS", "length": 265 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DW11-1", "protein_name": "TATA-box-binding protein-associated factor 11-like protein 6", "gene_name": "TAF11L6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METGRQTGVSAEMLAMPRGLKGSKKDGIPEDLDGNLEAPRDQEGELRSEDVMDLTEGDSEASASAPPAAKRRKTHTKGKKESKPTVDAEEAQRMTTLLSAMSEEQLSRYEVCRRSAFPRARVAGLMRAITGSSVSENAAIAMAGIAKLFVGEVVEEALDVCEMWGETPPLQPKHLREAVRRLKPKGLFPNSNCKRIMF", "length": 198 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DW12-1", "protein_name": "TATA-box-binding protein-associated factor 11-like protein 7", "gene_name": "TAF11L7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METGRQTGVSAEMLAMPRGLKGSKKDGIPEDLDGNLEAPRDQEGELRSEDVMDLTEGDSEASASAPPAAKRRKTHTKGKKESKPTVDAEEAQRMTTLLSAMSEEQLSRYEVCRRSAFPRARVAGLMRAITGSSVSENAAIAMAGIAKLFVGEVVEEALDVCEMWGETPPLQPKHLREAVRRLKPKGLFPNSNCKRIMF", "length": 198 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DW13-1", "protein_name": "TATA-box-binding protein-associated factor 11-like protein 8", "gene_name": "TAF11L8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METGRQTGVSAEMLAMPRGLKGSKKDGIPEDLDGNLEAPRDQEGELRSEDVMDLTEGDSEASASAPPAAKRRKTHTKGKKESKPTVDAEEAQRMTTLLSAMSEEQLSRYEVCRRSAFPRARVAGLMRAITGSSVSENAAIAMAGIAKLFVGEVVEEALDVCEMWGETPPLQPKHLREAVRRLKPKGLFPNSNCKRIMF", "length": 198 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P0DW14-1", "protein_name": "TATA-box-binding protein-associated factor 11-like protein 10", "gene_name": "TAF11L10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "METGRQTGVSAEMLAMPRGLKGSKKDGIPEDLDGNLEAPRDQEGELRSEDVMDLTEGDSEASASAPPAAKRRKTHTKGKKESKPTVDAEEAQRMTTLLSAMSEEQLSRYEVCRRSAFPRARVAGLMRAITGSSVSENAAIAMAGIAKLFVGEVVEEALDVCEMWGETPPLQPKHLREAVRRLKPKGLFPNSNCKRIMF", "length": 198 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P11588-1", "protein_name": "Major urinary protein 1", "gene_name": "Mup1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLENSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAQLCEKHGILRENIIDLSNANRCLQARE", "length": 180 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P11589-1", "protein_name": "Major urinary protein 2", "gene_name": "Mup2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKMLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLEKSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEKDGETFQLMGLYGREPDLSSDIKERFAKLCEEHGILRENIIDLSNANRCLQARE", "length": 180 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P13255-1", "protein_name": "Glycine N-methyltransferase", "gene_name": "Gnmt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVDSVYRTRSLGVAAEGIPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCHRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRKEPAFDKWVIEEANWLTLDKDVPAGDGFDAVICLGNSFAHLPDSKGDQSEHRLALKNIASMVRPGGLLVIDHRNYDYILSTGCAPPGKNIYYKSDLTKDITTSVLTVNNKAHMVTLDYTVQVPGAGRDGAPGFSKFRLSYYPHCLASFTELVQEAFGGRCQHSVLGDFKPYRPGQAYVPCYFIHVLKKTG", "length": 293 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P13675-1", "protein_name": "Y-linked testis-specific protein 1", "gene_name": "Ssty1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSLMKKRRRKSSSNTLRNIVSCRISHSWKEGNEPVTQWKAIVLDQLPTNPSLYFVKYDGIDSIYVLELYSDDRILNLKVLPPIVVFPQVRDAHLARALVGRAVQHKFERKDGSEVNWRGVVLAQVPIMKDLFYITYKKDPALYAYQLLDDYKEGNLHMIPDTPPAEERSGDDSDVLIGNWVEYTRKDGSKKFGKVVYQVLANPSVYFIKFHGDIHIYVYTMVPKILEVEKS", "length": 232 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P15515-1", "protein_name": "Histatin-1", "gene_name": "HTN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKFFVFALVLALMISMISADSHEKRHHGYRRKFHEKHHSHREFPFYGDYGSNYLYDN", "length": 57 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P16374-1", "protein_name": "Zinc finger protein 60", "gene_name": "Zfp60", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANSSSQHMVCGSVTFRDVAVDFSQEEWACLDATQKVLYRNIMLETYSNLVAVVGRCIPKPDLIVLLEPEKEPWMAVKKETGRPSQGLETGFEAENRSPKNHVYNKKLPKQTIQQLSKTSDVQGVSVSNGPGYSVIKEPQNYQEGDANRNITNKKEMSTYTSKTLAHNKEKPYKCKDCGKCFGCKSNLHQHESIHTGEKPYECKDCGKTFRLPQMLSRHQKSHSDERPFECNICGKSFHLPTLLQYHKNIHTGLKPFECEECGKSFKSFNRISTLFQHRTIHAGMKPYKCNVCGKAFNRRSNLLQHQKIHSEDRPFHCKVCGKAFTVLAQLTRHENIHTEDKSFECKQCGKIFSNGSYLLRHYDTHTNEKPFECNICGKAFRLHLYLSEHQKTHTDEKPFKCKLCESAFRRKYQLSEHQRIHTDGKPYQCKDCWEFFRRRSNFIEHQSIHTGKKPFECKDCGKVFRLNIHLIRHQRFHSDEKPFECKECGKAFHFSSQLNNHKTSHTGQTPFECKECGKSFKRVSSLVEHRIIHSGVKPYKCNACGRAFNRRSNLMQHEKIHSDERPFECKDCGKAFTVLAQLTRHQTIHNGKKSYECEQCGSAFRLPYQLTQHQRIHYDVKPFQCKECGRAFVRSTGLRIHERIHTGEKPFQCKECGEAFQYHYQFLGHFRIHTGKNPYECSECGKYFTYGRDLKVHQSIHNLEKP", "length": 707 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P20816-1", "protein_name": "Cytochrome P450 4A2", "gene_name": "Cyp4a2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGFSVFSPTRSLDGVSGFFQGAFLLSLFLVLFKAVQFYLRRQWLLKALEKFPSTPSHWLWGHNLKDREFQQVLTWVEKFPGACLQWLSGSTARVLLYDPDYVKVVLGRSDPKPYQSLAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGVIKTRKAQLQNEEELQKARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGTSVTWDHLDQMPYTTMCIKEALRLYSPVPSVSRELSSPVTFPDGRSIPKGIRVTILIYGLHHNPSYWPNPKVFDPSRFSPDSPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNGIHLRLKKLR", "length": 504 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P21571-1", "protein_name": "ATP synthase peripheral stalk subunit F6, mitochondrial", "gene_name": "Atp5pf", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTVQRIFRLSSVLRSAVSVHLRRNIGVTAVAFNKELDPVQKLFLDKIREYKAKRLASGGPVDTGPEYQQEVDRELFKLKQMYGKGEMDKFPTFNFEDPKFEVLDKPQS", "length": 108 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P22237-1", "protein_name": "NADH-ubiquinone oxidoreductase subunit 9", "gene_name": "nad9", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKDYKNELKVKINLGEHLRLSIPGLVKKIMYKTHYLEIQVEKEKMLTVLKYLKEASKYQCNMLLDIVCVDCLNIEEIKIGRFKLIYVLNSIYNNTRVHLSTYVENNGIIETTSGLFESSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFPITGYLEVYYDVNDKKIIYKPIELMQEYRNYNFGAVWGDYERKVYLENIIK", "length": 209 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "P22283-1", "protein_name": "Cystatin-related protein 2", "gene_name": "Crp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYKTLCGTQLLLAIFVLFLNFSHATAKGTRGPMEIFKKNFMEKNKLNDVYDIFKFLYNKFSHDTYLSNIKNQSFTMNTWGFGEIEVVKTKCRKIDSDFYKCSFQWEFCNIKRTPGVTIYYITLPGSVRCRKLLSKLVNCPFEEQTEQLKREICYFQLYPDYIEQNIRSVRFNCYTK", "length": 176 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P23266-1", "protein_name": "Olfactory receptor 1f45", "gene_name": "Or1f45", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSTNQSSVTEFLLLGLSRQPQQQQLLFLLFLIMYLATVLGNLLIILAIGTDSRLHTPMYFFLSNLSFVDVCFSSTTVPKVLANHILGSQAISFSGCLTQLYFLAVFGNMDNFLLAVMSYDRFVAICHPLHYTTKMTRQLCVLLVVGSWVVANMNCLLHILLMARLSFCADNMIPHFFCDGTPLLKLSCSDTHLNELMILTEGAVVMVTPFVCILISYIHITCAVLRVSSPRGGWKSFSTCGSHLAVVCLFYGTVIAVYFNPSSSHLAGRDMAAAVMYAVVTPMLNPFIYSLRNSDMKAALRKVLAMRFPSKQ", "length": 313 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P24049-1", "protein_name": "Large ribosomal subunit protein uL22", "gene_name": "Rpl17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE", "length": 184 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P24868-1", "protein_name": "G2/mitotic-specific cyclin-1", "gene_name": "CLB1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSRSLLVENSRTINSNEEKGVNESQYILQKRNVPRTILGNVTNNANILQEISMNRKIGMKNFSKLNNFFPLKDDVSRADDFTSSFNDSRQGVKQEVLNNKENIPEYGYSEQEKQQCSNDDSFHTNSTALSCNRLIYSENKSISTQMEWQKKIMREDSKKKRPISTLVEQDDQKKFKLHELTTEEEVLEEYEWDDLDEEDCDDPLMVSEEVNDIFDYLHHLEIITLPNKANLYKHKNIKQNRDILVNWIIKIHNKFGLLPETLYLAINIMDRFLCEEVVQLNRLQLVGTSCLFIASKYEEIYSPSIKHFAYETDGACSVEDIKEGERFILEKLDFQISFANPMNFLRRISKADDYDIQSRTLAKFLMEISIVDFKFIGILPSLCASAAMFLSRKMLGKGTWDGNLIHYSGGYTKAKLYPVCQLLMDYLVGSTIHDEFLKKYQSRRFLKASIISIEWALKVRKNGYDIMTLHE", "length": 471 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P25389-1", "protein_name": "Probable serine/threonine-protein kinase KCC4", "gene_name": "KCC4", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTVANTETHSAAKPSSTIGPWKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQIIIGISYCHALGIVHRDLKPENLLLDSFYNIKIADFGMAALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEISRDAQDLIGKILVVDPRQRIKIRDILSHPLLKKYQTIKDSKSIKDLPRENTYLYPLADSNNHTSASIDDSILQNLVVLWHGRHADDIVSKLKENGTNKEKILYALLYRFKLDSVRGSNKKNRNKIKKTKKNKRSSTLSSSSSLLLNNRSIQSTPRRRTSKRHSREFSSSRKRSSFLLSSNPTDSSPIPLRSSKRITHINVASANTQATPSGVPNPHKRNSKKRSSKRLSYMPNTKRSSLTSKSLSNFTNLIDDDDWEYIEKDAKRTSSNFATLIDEIFEPEKFELAKREKAELQRKVQEAKRQSVNAQKINEDEFGSEVSDGMKELKKINDKVSSPLINYEFSQQELLQDIDTLLTNRYQLSSYTRPISRLDPGLTPVTETLPNNLKEKTALLQDTEKKIIETIRRSKFLGSLLNVRGGLSPGKSELAPIEESPIVSTTPLIYNDRMEPRRISDVEVPHFTRKSKHFTTANNRRSVLSLYAKDSIKDLNEFLIKEDPDLPPQGSTDNESRSEDPEIAESITDSRNIQYDEDDSKDGDNVNNDNILSDFPQGVGISQEYDMKDKNPNQSPISKSAEPTLVVKLPSLSSFQGKNASGLGLYQREPSKVTLPSLTSNNSSVGENIEDGAEKGTESEKIAASLSDDDLKEDNDKKDNDTVNAPTTVKKPPNSVLLKKFSKGKILELEIHAKIPEKRLYEGLHKLLEGWKQYGLKNLVFNITNMIITGKLVNDSILFLRSTLFEIMVLPNGDGRSLIKFNKKTGSTKTLTKLATEIQIILQKEGVLDK", "length": 1037 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P28312-1", "protein_name": "Alpha-defensin 5", "gene_name": "Defa5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTFVLLSALVLLAFQVQADPIHKTDEETNTEEQPGEEDQAVSISFGGQEGSALHEELSKKLICYCRIRGCKRRERVFGTCRNLFLTFVFCCS", "length": 93 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P28742-1", "protein_name": "Kinesin-like protein KIP1", "gene_name": "KIP1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MARSSLPNRRTAQFEANKRRTIAHAPSPSLSNGMHTLTPPTCNNGAATSDSNIHVYVRCRSRNKREIEEKSSVVISTLGPQGKEIILSNGSHQSYSSSKKTYQFDQVFGAESDQETVFNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSGDINILGDVQSTDNLLLGEHAGIIPRVLVDLFKELSSLNKEYSVKISFLELYNENLKDLLSDSEDDDPAVNDPKRQIRIFDNNNNNSSIMVKGMQEIFINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFTITTNIVEQDSKDHGQNKNFVKIGKLNLVDLAGSENINRSGAENKRAQEAGLINKSLLTLGRVINALVDHSNHIPYRESKLTRLLQDSLGGMTKTCIIATISPAKISMEETASTLEYATRAKSIKNTPQVNQSLSKDTCLKDYIQEIEKLRNDLKNSRNKQGIFITQDQLDLYESNSILIDEQNLKIHNLREQIKKFKENYLNQLDINNLLQSEKEKLIAIIQNFNVDFSNFYSEIQKIHHTNLELMNEVIQQRDFSLENSQKQYNTNQNMQLKISQQVLQTLNTLQGSLNNYNSKCSEVIKGVTEELTRNVNTHKAKHDSTLKSLLNITTNLLMNQMNELVRSISTSLEIFQSDSTSHYRKDLNEIYQSHQQFLKNLQNDIKSCLDSIGSSILTSINEISQNCTTNLNSMNVLIENQQSGSSKLIKEQDLEIKKLKNDLINERRISNQFNQQLAEMKRYFQDHVSRTRSEFHDELNKCIDNLKDKQSKLDQDIWQKTASIFNETDIVVNKIHSDSIASLAHNAENTLKTVSQNNESFTNDLISLSRGMNMDISSKLRSLPINEFLNKISQTICETCGDDNTIASNPVLTSIKKFQNIICSDIALTNEKIMSLIDEIQSQIETISNENNINLIAINENFNSLCNFILTDYDENIMQISKTQDEVLSEHCEKLQSLKILGMDIFTAHSIEKPLHEHTRPEASVIKALPLLDYPKQFQIYRDAENKSKDDTSNSRTCIPNLSTNENFPLSQFSPKTPVPVPDQPLPKVLIPKSINSAKSNRSKTLPNTEGTGRESQNNLKRRFTTEPILKGEETENNDILQNKKLHQ", "length": 1111 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P29314-1", "protein_name": "Small ribosomal subunit protein uS4", "gene_name": "Rps9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVWRVKFTLAKIRKAARELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKIEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPYGGGRPGRVKRKNAKKGQGGAGAGDDEEED", "length": 194 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P33579-1", "protein_name": "Prolactin-8A5", "gene_name": "Prl8a5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELALSQPSFFGTLLMLVVSNLLLWEKAASIPACMVEDGGCWDPLREAFNSATQRAETLRNLSDQLYVEFFQNQFSSRQFADLSSQLIRKDETVLKAGTYCHSNRAKPKSRGVNIDIEEYLKMSINFCGFMDQPLFHLVIELSAMEGVPETILSKAKDLEENNRQLLDDLRWILTKVFPTAEIKEEFPSWDYLSFLKSSNKNHKFLAIFNLSSCLDYDTQVHYTLSQILNCLITGKDC", "length": 238 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P36006-1", "protein_name": "Myosin-3", "gene_name": "MYO3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAVIKKGARRKDVKEPKKRSAKIKKATFDANKKKEVGISDLTLLSKISDESINENLKKRFKNGIIYTYIGHVLISVNPFRDLGIYTNAVLESYKGKNRLEVPPHVFAIAESMYYNLKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASNSHSESIGKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNSQFEPCAGNITNYLLEKQRVVGQIKNERNFHIFYQFTKGASDTYKQMFGVQMPEQYIYTAAAGCTTADTIDDVKDYEGTLEAMRTIGLVQEEQDQIFRMLAAILWIGNISFIENEEGNAQVGDTSVTDFVAYLLQVDASLLVKCLVERIMQTSHGMKRGSVYHVPLNPVQATAVRDALAKAIYNNLFDWIVDRVNVSLQAFPGADKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKAEQETYEREKIKWTPIKYFDNKVVCDLIEAKNPPGILAAMNDSIATAHADSNAADQAFAQRLNLFNSNPYFELRANKFVIKHYAGDVTYDINGITDKNKDQLQKDLIELIGTTTNTFLSTIFPDDVDKDSKRRPPTAGDKIIKSANELVETLSKAEPSYIRTIKPNQTKSPNDYDDHQVLHQVKYLGLQENVRIRRAGFAYRQTFEKFVERFYLLSPDCSYAGDYTWDGDTLEAVKLILRDAMIPEKEFQLGVTSVFIKTPESLFALEDMRDKYWYNMAARIQRAWRRFLQRRIDAAIKIQRTIREKKGGNKYVKLRDYGTKLLAGKKERRSMSLLGYRAFMGDYLSCNESKTKGSYIRRQVGIKDKVVFSIKGECLHSKFGRSAQRLKKVFILTKKTFYIIGQTREQNAMKYTQDYKIDVGKIKQVSLTNLQDDWMGVILVNSTQSDPLINTPFKTELMTRLKKLNEKIMIKVGPTIEYHKQPNKLHTVRSKISDSAPKYGDIYKSSTIYVRRGHPANSKSNKKPKNPGGLSGKPIKSKKSKHKSTHKHTHSHRSHRDAAKKQPLPSQKPVNPLSLAATAAQAAYNPKPDKTVPIKSSAIPAAKVSSKHSSKPSSKEKVAVKKASSSHKSSSAKQNQVSMPPSKGVEKNKEPLKETTATATANIPIPPPPPPMGQPKDPKFEAAYDFPGSGSSSELPLKKGDIVFISRDEPSGWSLAKLLDGSKEGWVPTAYMTPYKDTRNTVPVAATGAVNDVTNQKSSQIDNTISSAQEGVQFGSATVGPTSDNQSNPVGTFSDGLASALAARANKMRAESADDDDNDDGDDDDDW", "length": 1272 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P36046-1", "protein_name": "Mitochondrial intermembrane space import and assembly protein 40", "gene_name": "MIA40", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLRNLVVRNACRNRPSIQVARGLCRHQTRRLMASSPQFGRNSNQEKTAGFIMGILSMAGALYFIAPNRKPLFASRKVESDKTAEEELSSGGEQSPENEDDNNSKSDENGDDNDSKNDETEAGPQLGGDKIGASKVAEDGELVVLAEEDNKSSEDKDTDESKVSTKDDEQSNEDNATANNQKDENISSENSEENTSDKTLDNNAGSSEKKDPEHSDDEKSQQGQSDDKTTTEDNNGEEESSKKTVSDSENSAKQSESSDEEKEELRKQEEKQMGPTEEEVQHEGAYNPDTGEINWDCPCLGGMAHGPCGEEFKSAFSCFVYSEAEPKGIDCVEKFQHMQDCFRKYPEHYAEQLKETSDDEEPQDKVKVNTIESAPNVSSAKENAAKKAEQSDVKKEPLNEESKP", "length": 403 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P37106-1", "protein_name": "Signal recognition particle subunit SRP54 1", "gene_name": "SRP-54A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVLAELGGRITRAIQQMNNVTIIDEKVLNDFLNEITRALLQSDVSFGLVEKMQTNIKKIVNLDDLAAGHNKRLIIEQAIFKELCRMLDPGKPAFAPKKAKPSVVMFVGLQGAGKTTTCTKYAYYHQKKGYKAALVCADTFRAGAFDQLKQNATKAKIPFYGSYTESDPVKIAVEGVDRFKKEKCDLIIVDTSGRHKQAASLFEEMRQVAEATEPDLVIFVMDSSIGQAAFEQAEAFKETVSVGAVIITKMDGHAKGGGALSAVAATKSPVIFIGTGEHMDEFEVFDVKPFVSRLLGKGDWSGLVDKLQEVVPKDLQNELVENLSQGNFTLRSMYDQFQCSLRIPLNQLFSMLPGISAEMMPKGHGEESRVKMKRYMTMMDSMTNKELDSPNPKIFNESRIMRIARGSGRLVREVMEMLEEYKRIAKTMKGIKIPKNGDMSKVIPPQMLKQMGGMSGLQSLMKQMGSAKDMMGMFGGGGK", "length": 479 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P38150-1", "protein_name": "Inactive deaminase YBR284W", "gene_name": "", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVQNNESVFFVECDSYKESPSTSPIRLDDLDGNDAVSDQGLAFDGDVGITSQARVRNPRAQIFEDSNTDVVLHLDDLDMVPLNTKFDMQMEMGSPMAMPAETPPPVEPLKTKDLAYSSLAHLPSYFFEQTHFRIDRKCLLEMSKLRRNYLTISKQDALSCPQLHSRVAGGYLKPVKEKLFGIRHFLDLEESNTVNLLQDGNYMTELFNSQINIPTFKEFREDFEWCLKIIRDRSLSRFSEKRLQYLVNKFPVFQHLHSKEEMRQSKKVPHKDFYNCRKIDLNLLLSGCFSQWQLTEFIWTKLRKEPDRVIHQAFNGSHITLSQLFKVNFEETGQFFNGLKIIDDSFLEWYKVIYLAKYHLVNDEMEIHTGSHGKQLRYYLIAKTFLEFDNYINGEYLAELLKTFLIKPQEESKYQLCQLSVDFQFYLHYDNSDVDNWWMVFANWLNHYNIFSNNIRWNIRISRIYPELYHTGKVKNFQEYLNLIFKPLFNAENYLHKSLGPILLKFLSQVSSIDLCIQDTDNYIWKNFTAVSCLPKDWTSGGDNPTISQYMYYVYVNLTKLNHIRQALHQNTFTLRSSCSPTSMNRTSQFSNTLNFTEHTEAILNNFLLACGGFLNAENLWNAPPSLVYLFYLSQIPMVVAPLNSIVDSKPTMLQEQAPTGLVLEPSKPYKKNPFMKFFEMGFKISLSSESILYNNSYTKEPIIEEYSVAASIYRLHSADLCELLRNSVITSGFSSTLKNKWLGVSLASHDYFVENTGFVDKWYDCKPNTSLEHNVPIIRRQYRSSTLAGEWRLIIA", "length": 797 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P40002-1", "protein_name": "Transcriptional regulator MIT1", "gene_name": "MIT1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MDIEPTFKGYIEDEDDALLILQATLDGKLKHIPRRPYEIERPYLIVSGSIFVFIEEISGIKRWTDGVSWSPSRISGKFLIYKELDKENAGSNANATSSGSTDSAVITDGTSGARNNPSSSKIKLPPLKNHQFDLPPTMGHSSFESEQDTSISPSNRSNLPLKYTGLVKKTISVKLKRPPFNSIENLHIVSYYSVKDIKQNCLVTPKASPFLKDVRPSQELIVAMGNTTLGNVKNNSTTTGNGPNNINNKSNSSTPLNTVISTNNNSANINAAGSNQFTSANKNYYYKNDESSGYPITQFAPALPSTTLMYTANPPYITQSPDNTNATGMNTHVNNNNNNSNNSSNSNNSNNNNNNNNNNNNNNNNNINNINNVNTNAGNGNNPNRFHNASFAYNTTGDFINPQQQGQISYPFYYTTIPINNPNYYTTQPPNPVTNASTNENQGYSTSSTQHPYYGHPTESQSASAAAGATGTPGTAENVLPVSSMQPLLHQANNNSASSATSTAPYPVYSMNVNVPYYNSSASAYKRAQENTTSNTNAEPSGATSTNSGTMLSNPAYANSQYTPSQVYYQGFPQYAMASAQNPSMYQHQHQHPLPTVYPIATPQQNIMSSGHTLSTIGSDPQHHHYQQEPNDHKNFAMGHANNNILNITNNDTMNNLNTNTSTTTQ", "length": 666 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P42222-1", "protein_name": "Enolase-related protein 3", "gene_name": "ERR3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSITKVHARTVYDSRGNPTVEVEITTENGLFRAIVPSGASTGIHEAVELRDGNKSEWMGKGVTKAVSNVNSIIGPALIKSDLCVTNQKGIDELMISLDGTSNKSRLGANAILGVSLCVARAAAAQKGITLYKYIAELADARQDPFVIPVPFFNVLNGGAHAGGSLAMQEFKIAPVGAQSFAEAMRMGSEVYHHLKILAKEQYGPSAGNVGDEGGVAPDIDTAEDALDMIVKAINICGYEGRVKVGIDSAPSVFYKDGKYDLNFKEPNSDPSHWLSPAQLAEYYHSLLKKYPIISLEDPYAEDDWSSWSAFLKTVNVQIIADDLTCTNKTRIARAIEEKCANTLLLKLNQIGTLTESIEAANQAFDAGWGVMISHRSGETEDPFIADLVVGLRCGQIKSGALSRSERLAKYNELLRIEEELGDDCIYAGHRFHDGNKL", "length": 437 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P43356-1", "protein_name": "Melanoma-associated antigen 2", "gene_name": "MAGEA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQQTASSSSTLVEVTLGEVPAADSPSPPHSPQGASSFSTTINYTLWRQSDEGSSNQEEEGPRMFPDLESEFQAAISRKMVELVHFLLLKYRAREPVTKAEMLESVLRNCQDFFPVIFSKASEYLQLVFGIEVVEVVPISHLYILVTCLGLSYDGLLGDNQVMPKTGLLIIVLAIIAIEGDCAPEEKIWEELSMLEVFEGREDSVFAHPRKLLMQDLVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHTLKIGGEPHISYPPLHERALREGEE", "length": 314 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P43357-1", "protein_name": "Melanoma-associated antigen 3", "gene_name": "MAGEA3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAELVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASSSLQLVFGIELMEVDPIGHLYIFATCLGLSYDGLLGDNQIMPKAGLLIIVLAIIAREGDCAPEEKIWEELSVLEVFEGREDSILGDPKKLLTQHFVQENYLEYRQVPGSDPACYEFLWGPRALVETSYVKVLHHMVKISGGPHISYPPLHEWVLREGEE", "length": 314 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P43537-1", "protein_name": "Uncharacterized membrane protein YFL067W", "gene_name": "", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MESIILSIAIFIGVLLGTSVGAGSGSSISPDVDAGSGSRTSPDVDAGSGSRISAGVGTFSGSSTSPDVDAGSGSSTSPDVGAGSGSSISAGVGSRIGTGIGSRIGTGIGTGIGSRISTSIGSRISPDVGTSSGNRISTGVSTGISTTMNARVAVLITAAILSAPVTAIALLEARR", "length": 175 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P46162-1", "protein_name": "Beta-defensin 4", "gene_name": "DEFB4", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MRLHHLLLAVLFLVLSAGSGFTQRVRNPQSCRWNMGVCIPFLCRVGMRQIGTCFGPRVPCCRR", "length": 63 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "P46169-1", "protein_name": "Beta-defensin 11", "gene_name": "DEFB11", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MRLHHLLLALLFLVLSAGSGISGPLSCRRNGGVCIPIRCPGPMRQIGTCFGRPVKCCRSW", "length": 60 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "P47102-1", "protein_name": "ARF guanine-nucleotide exchange factor 1", "gene_name": "GEA1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MHDVPMETVLAVNPATMIVKECINLCSAMNKQSRDKSQTSVAALLGGGSDIFLSQSDSFVDSFHNLPTSSYHDPLISGLVQLRLKINDLKGLDSLNALELLKPFLEIVSASSVSGYTTSLALDSLQKVFTLKIINKTFNDIQIAVRETVVALTHCRFEASKQISDDSVLLKVVTLLRDIITSSFGDYLSDTIIYDVLQTTLSLACNTQRSEVLRKTAEVTIAGITVKLFTKLKLLDPPTKTEKYINDESYTDNNLKDDIIGTTTSDNDLSSTDDDSAVADDNKNEKPVQQVIREQENDEETAEKAENVEPNYGITVIKDYLGLLLSLVMPENRMKHTTSAMKLSLQLINAAIEISGDKFPLYPRLFSLISDPIFKSVLFIIQSSTQYSLLQATLQLFTSLVVILGDYLPMQIELTLRRIFEILEDTTISGDVSKQKPPAIRELIIEQLSILWIHSPAFFLQLFVNFDCNLDRSDLSIDFIKELTKFSLPAAAVNTSNNIPPICLEGVLSLIENIYNDLQRFDRAEFVKNQKEIDILKQRDRKTEFILCVETFNEKAKKGIQMLIEKGFIDSDSNRDIASFLFLNNGRLNKKTIGLLLCDPKKTSLLKEFIDLFDFKGLRVDEAIRILLTKFRLPGESQQIERIVEAFSSKYSADQSNDKVELEDKKAGKNGSESMTEDDIIHVQPDADSVFVLSYSIIMLNTDSHNPQVKDHMTFDDYSNNLRGCYNGKDFPRWYLHKIYTSIKVKEIVMPEEHHGNERWFEDAWNNLISSTSVMTEMQRDFTNPISKLAQIDILQYEKAIFSNVRDIILKTLFKIFTVASSDQISLRILDAISKCTFINYYFSFDQSYNDTVLHLGEMTTLAQSSAKAVELDVDSIPLVEIFVEDTGSKISVSNQSIRLGQNFKAQLCTVLYFQIIKEISDPSIVSTRLWNQIVQLILKLFENLLMEPNLPFFTNFHSLLKLPELPLPDPDISIRKAKMSRSLLSTFASYLKGDEEPSEEDIDFSIKAFECVKASHPLSSVFENNQLVSPKMIETLLSSLVIEKTSENSPYFEQELLFLLEISIILISEASYGQEFGALIADHMINISNLDGLSKEAIARLASYKMFLVSRFDNPRDILSDLIEHDFLVKNEIFNTKYYESEWGKQVINDLFTHLNDVKYNERALKNVKFWNFLRILISAKDRQFAVYTFLEKYIQNGDIFVDDGNFMNILSLLDEMSCAGAVGTKWEQNYENSVEDGCEAPESNPYRSIIDLSSRSINITADLLSTVGRSNSALNKNEIIAAIQGLAHQCLNPCDELGMQALQALENILLSRASQLRTEKVAVDNLLETGLLPIFELDEIQDVKMKRITSILSVLSKIFLGQLVEGVTSNETFLRVLNVFNKYVDDPTVERQLQELIISKREIEKE", "length": 1408 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P53563-1", "protein_name": "Bcl-2-like protein 1", "gene_name": "Bcl2l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEPERETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEPWIQENGGWDTFVDLYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK", "length": 233 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P56840-1", "protein_name": "Protein TCL1B1", "gene_name": "Tcl1b1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAAFDPLGPLPVYLVSVRLGIYEDEHHRVWIVANVETSHSSHGNRRRTHVTVHLWKLIPQQVIPFNPLNYDFLPTTWKLESRNIYWATDGTHWRLLDHSQLGDTEQLILMLVLG", "length": 116 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P56841-1", "protein_name": "Protein TCL1B2", "gene_name": "Tcl1b2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAGFYPPRLLPQVLISTGPGFYEDEHHRLWMVAKLETCSHSPYCNKIETCVTVHLWQMTRYPQEPAPYNPMNYNFLPMTWRLASMNTYRGTDAMHWRLLNHSQVGDTVQLILMLE", "length": 117 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P56842-1", "protein_name": "Protein TCL1B3", "gene_name": "Tcl1b3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADSVHFPWMPFPPRFLVCTRDDIYEDENGRQWVVAKVETSRSPYGSRIETCITVHLQHMTTIPQEPTPQQPINNNSLPTMWRLESMNTYTGTDGTYWRLLDHSQMGDTLQLILDIVICEVD", "length": 122 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P56844-1", "protein_name": "Protein TCL1B4", "gene_name": "Tcl1b4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADSVRFPCMPFPPCFLVCTRDDIYEDEHGRQWVAAKVETSSHSPYCSKIETCVTVHLWQMTTLFQEPSPDSLKTFNFLPRTWRLESRNTYRGADAMHWRLVNHSQFYGTEELVLMLDSR", "length": 120 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P59528-1", "protein_name": "Taste receptor type 2 member 123", "gene_name": "Tas2r123", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSQKINYSHLFTFSITLYVEIVTGILGHGFIALVNIMDWVKRRRISSVDQILTALALTRFIYVLSMLICILLFMLCPHLPRRSEMLSAMGIFWVVNSHFSIWLTTCLGVFYFLKIANFSNSFFLYLKWRVKKVILIIILASLIFLTLHILSLGIYDQFSIAAYVGNMSYSLTDLTQFSSTFLFSNSSNVFLITNSSHVFLPINSLFMLIPFTVSLVAFLMLIFSLWKHHKKMQVNAKQPRDVSTMAHIKALQTVFSFLLLYAIYLLFLIIGILNLGLMEKIVILIFDHISGAVFPISHSFVLILGNSKLRQASLSVLPCLRCQSKDMDTMGL", "length": 333 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P61314-1", "protein_name": "Large ribosomal subunit protein eL15", "gene_name": "Rpl15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLHRYR", "length": 204 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P62246-1", "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "Rps15a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF", "length": 130 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P62425-1", "protein_name": "Large ribosomal subunit protein eL8", "gene_name": "Rpl7a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYIRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEKKAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGNVLGPKSVARIAKLEKAKAKELATKLG", "length": 266 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P62802-1", "protein_name": "Histone H4", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG", "length": 103 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P62963-1", "protein_name": "Profilin-1", "gene_name": "Pfn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGWNAYIDSLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVSITPAEVGVLVGKDRSSFFVNGLTLGGQKCSVIRDSLLQDGEFTMDLRTKSTGGAPTFNVTVTMTAKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY", "length": 140 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P62982-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "Rps27a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMGSHFDRHYCGKCCLTYCFNKPEDK", "length": 156 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P70709-1", "protein_name": "Eosinophil cationic protein", "gene_name": "Rnase3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLKLLESRLCLLLSLGLVLMLASCQPPTPSQWFEIQHIYNRAYPRCNDAMRHRNRFTGHCKDINTFLHTSFASVVGVCGNRNIPCGNRTYRNCHNSRYRVSITFCNLTTPARIYTQCRYQTTRSRKFYTVGCDPRTPRDSPMYPVVPVHLDRIF", "length": 155 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P81278-1", "protein_name": "Prolactin-releasing peptide", "gene_name": "Prlh", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALKTWLLCLLLLSLVLPGASSRAHQHSMETRTPDINPAWYTGRGIRPVGRFGRRRATPRDVTGLGQLSCLPLDGRTKFSQRG", "length": 83 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P83883-1", "protein_name": "Large ribosomal subunit protein eL42", "gene_name": "Rpl36a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF", "length": 106 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P83884-1", "protein_name": "Large ribosomal subunit protein eL42", "gene_name": "RPL36A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF", "length": 106 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P97876-1", "protein_name": "Basic leucine zipper transcriptional factor ATF-like 3", "gene_name": "Batf3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQGPPAGGVLQSSVAAPGNQPQSPKDDDRKVRRREKNRVAAQRSRKKQTQKSDKLHEEHESLEQENSVLRREIAKLKEELRHLTEALKEHEKMCPLLLCPMNFVQLRPDPVASWSAHDAPDHPSFIWLGTLV", "length": 133 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q00729-1", "protein_name": "Histone H2B type 1-A", "gene_name": "H2bc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPEVSAKGTTISKKGFKKAVTKTQKKEGRKRKRCRKESYSIYIYKVLKQVHPDTGISSKAMSIMNSFVTDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK", "length": 127 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q01534-1", "protein_name": "Testis-specific Y-encoded protein 1", "gene_name": "TSPY1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRPEGSLTYRVPERLRQGFCGVGRAAQALVCASAKEGTAFRMEAVQEGAAGVESEQAALGEEAVLLLDDIMAEVEVVAEEEGLVERREEAQRAQQAVPGPGPMTPESAPEELLAVQVELEPVNAQARKAFSRQREKMERRRKPHLDRRGAVIQSVPGFWANVIANHPQMSALITDEDEDMLSYMVSLEVGEEKHPVHLCKIMLFFRSNPYFQNKVITKEYLVNITEYRASHSTPIEWYPDYEVEAYRRRHHNSSLNFFNWFSDHNFAGSNKIAEILCKDLWRNPLQYYKRMKPPEEGTETSGDSQLLS", "length": 308 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q03764-1", "protein_name": "Ethanolamine kinase", "gene_name": "EKI1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MYTNYSLTSSDAMPRTYLVGTASPEMSKKKRQSANCDKPTRRVIHIIDTNEHSEVDLKNELPITCTNEDGEMTSSSWTSQTANDFLKLAYVNAKLDPSLPSQYFKQDIINVLQSLEIPGWSVPGSKESSLNKNLLTLTQIKGALTNVIYKIHYPNLPPLLMRIFGDSIDSVIDREYELKVIARLSFYDLGPKLEGFFENGRFEKYIEGSRTSTQADFIDRDTSIKIAKKLKELHCTVPLTHKEITDQPSCWTTFDQWIKLIDSHKEWVSNNVNISENLRCSSWNFFLKSFKNYKRWLYNDSAFTSKLLREDDKDSMINSGLKMVFCHNDLQHGNLLFKSKGKDDISVGDLTIIDFEYAGPNPVVFDLSNHLNEWMQDYNDVQSFKSHIDKYPKEEDILVFAQSYINHMNENHVKIASQEVRILYNLIIEWRPCTQLFWCLWALLQSGRLPQRPLIEGEKLMSEKAGLGDETHLMEHKNKENGKYDCSEDDSFNYLGFCKEKMSVFWGDLITLGVIDKDCPDIGKTDYLDTKLIF", "length": 534 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q04902-1", "protein_name": "Probable glutathione-independent glyoxalase SNO4", "gene_name": "SNO4", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTPKRALISLTSYHGPFYKDGAKTGVFVVEILRSFDTFEKHGFEVDFVSETGGFGWDEHYLPKSFIGGEDKMNFETKNSAFNKALARIKTANEVNASDYKIFFASAGHGALFDYPKAKNLQDIASKIYANGGVIAAICHGPLLFDGLIDIKTTRPLIEGKAITGFPLEGEIALGVDDILRSRKLTTVERVANKNRAKYLAPIHPWDDYSITDGKLVTGVNANSSYSTTIRAINALYS", "length": 237 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q0D2J5-1", "protein_name": "Zinc finger protein 763", "gene_name": "ZNF763", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPVACEDVAVNFTQEEWALLDISQRKLYREVMLETFRNLTSIGKKWKDQNIEYEYQNPRRNFRSLIEGNVNEIKEDSHCGETFTQVPDDRLNFQEKKASPEAKSCDNFVCGEVGIGNSSFNMNIRGDIGHKAYEYQDYAPKPYKCQQPKKAFRYHPSFRTQERNHTGEKPYACKECGKTFISHSGIRRRMVMHSGDGPYKCKFCGKAVHCLRLYLIHERTHTGEKPYECKQCVKSFSYSATHRIHERTHTGEKPYECQQCGKAFHSSSSFQAHKRTHTGGKPYECKQCGKSFSWCHSFQIHERTHTGEKPCECSKCNKAFRSYRSYLRHKRSHTGEKPYQCKECRKAFTYPSSLRRHERTHSAKKPYECKQCGKALSYKFSNTPKNALWRKTL", "length": 394 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q0WX57-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein 24", "gene_name": "USP17L30", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDDSLYLRGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSDVTGNKIAKNVQYPECLDMQPYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVRKVEGTLPPDVLVIHQSKYKCGMKNHHPEQQSSLLNLSSSTPTHQESMNTGTLASLRGRARRSKGKNKHSKRALLVCQ", "length": 530 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q1LYG5-1", "protein_name": "Elongation factor 2a.1", "gene_name": "eef2a.1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MENFNVDQIRATMDKKSNIRNMSVIGAFDHGKSTLTDWLVSEAGIVSSARAGETRFMDTRRDEQERCITIKSTAISIFYELAEKDLAFIKECKDGSGFLLNLIDSPGHVDFSSEVTAALRITDGALLVVDCVSGVCLQTETVLRQAIGERIKPVLMINKMDRALLELQLVPEELYQIFQRIVEKVNVTISTYAEDEKGPMGNVMIDPVIGNLAFGSGLHGWAFTLKQFAELYVKKFAGKAQLGPEEYIKKVEDMIKRLWGDSYFDSTTGKFSESATSPDGKKLPRTFVHLVLDPIFKVFDAIMNFKKEETVKLIEKMGIKLDVEDKEKEGKILLKAVMRCWLPAGEALLQMITIHLPSPVTAQIYRCELLYEGPGDDEAAMGIKNCDPKAPLMMYISKMIPTSDKGCFYAFGRVFSGCVSTGLNVRIMGPNFTPGKKDDLYLKPIQRTVLMMGRYVEPIEDVPCGNIVGLLGVDQFLVKTGTITTFTKAYNMRVMKFSVSPVVRVSVEVMDPADLPKLVEGLKHLAKSDPMLQCIIEDTGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPFASYRETVSDGSKQLCLAKTPNKHSRLFMKACPLADGLAEDIDKGRVTASQEMNARAQYLAENYKWEVTEARKIWCFGPEGTGPNILVDLTKRVQYLNEIKDSVIAGFQWATREGVLCAENMRGIRFDIHDATLTSTAIHRGPGQIIVATRRVLYGCQLTAEPRLSEPIYLVEMQCPESVIGNVYGELVRRRGVVFSESQVMGTPVYLLKAYLPVSESFGFTADLCANTSGQAFSQCVFDHWQILPGDPMDPTSKVAHIMADIRKSKGLDEAIPALHCYLD", "length": 854 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q1PEY5-1", "protein_name": "Probable 3-hydroxyisobutyryl-CoA hydrolase 2", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MASHSQVLVEEKSSVRILTFNRPKQLNALSFHMVSRLLQLFLAYEEDPSVKLVVLKGQGRAFSAGGDIPPIVRDILQGKLIRGAHYFKVGYTLNYVLSTYRKPQVSILNGIVMGGGAGLSTNGRFRIATENTVFAMPETALGLFPDVGASYFLSRLPGFFGEYVGLTGARLDGAEMLACGLATHFVPSISLTALEAELYKVGSSNQTFISTILDAYAEYPHLNQHSSYHRLDVIDRCFSKRTVEEIFSALEREVTQKPNDWLLATIQALEKASPSCLKISLRSIREGRLQGVGQCLIREYRMVCHVMKGDISKDFVEGCRAVLIDKDRNPKWQPRRLEDVTDSMVDQYFERVEDEEGWEDLKFPPRNNLPALAIAAKL", "length": 378 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q1ZXA5-1", "protein_name": "ADP-ribosylation factor-like protein DDB_G0292332", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDFIISFIKNLFGFLTIKKVMILGVENVGKTTLLYNIYKFYSENITTTTLSSLPIPIPTNGFNVESIVIEQVKFDIWDIGGKETNRICYRHYLTSEIDSIIFVFDSSDINSLEESKKEYQYLKNQISLKNVPFLLVANKQDLKQQTIEIDEILKTYFDKSSINETILMSQNNNDDLIKCINWIFSN", "length": 186 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q1ZXJ4-1", "protein_name": "Acetyl-coenzyme A transporter 1", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLFTLLKRHFGNELNNIVWLVLLYLIQGIPIGLSFGTIPFLLHKHATYTQIGIFTISTYPYSLKLLWSPIVDSYFVQSFGRRKSWIVPIQILAGIVFITISFFIETLLEHAETKIIYITIVFFLLIFLMATQDIAVDAWALTILSKPYLHYASTCQTIGLNTGYFLSYTIFLTLSSPKFANKFLRSVPSEEGIITLPGYLQFWGILFIILSIYLAFFKDEESTTITTTTTRHDNYNNNNNDDKNKQVKSKIENESIESKSMRSSPSSLSPSLLSSPVKKQNKKNKQHISIDKKDITIIKENNENNEIIDNNNSNNNYDNGKKSIVQETYGMDISESDLTPKQVYYLLWKIITLPHIKILSILFIISKIVFQPNESALNLKLLEKGLRKEDIASFSLIQFPSIIIFSIISSKWVKNKPLTIWSNAYLVGVFFILVNMCSVFYFPNLNGGEISWSHFFLLLMISLFSSFSYNLMSVSQGSFFLKISDKSIGGTYVTLLNTIANFAGTYPKLFILMLIDKLTTSECIVNISNDNSSSSSSSSSLISTSSNNLTTTTTIIQEQQQQVIIHDNISKELCAEQNGKYRIERDGYYLVATGAIIYGVFIYFVLKRYLTPIEKLKL", "length": 618 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q23888-1", "protein_name": "Large ribosomal subunit protein uL2m", "gene_name": "mrpl2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVLNWRGVKSRLYSGKRRIDGRNKGLIAIRSRGGALKRKYRYIEHYKQKWMDKWLFVMRIEYDPNRSAHIALCSILKEGIYFYVISIAKLEVGSLIITSALKLGTLQVGNTTKIKNIPEGLLINNIELIENSGSKISRAAGTSSLIIKKYNKKYSLVKLSSKECRLISNECYATIGTVSNIERKLKQNKKASYSRKRGIRPIVRGLAMNPVDHPHGGRTKGGVHWKSFSGKLAYNVSSRKKTKMTSRYIIIGHRKQKIMDKQIKNG", "length": 266 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q24113-1", "protein_name": "Protein no-on-transient A", "gene_name": "nonA-l", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEGAVKKNSLNSSPLPQRQQRGNSTNKNLGKPTPPKLNAASDGNPAEKKARLGGNTQNGGGVAGGGGTGGGGGGGGATGGVEFSRNRNRGGNQNENRQGFQVANNSHQKQINESPKPAAGNVPAKNNELSAGGGGQNQPNHSNKGQGNQGDQGEQGNQGPNFRGRGGGPNQPNQNANQEQSNGYPGNQGDNKGGQGQRGAGGGKHQRGNRSRRSGGSGIMNSSMGGGGQRGEDFFIAQRLLDISGPTHELPPIELPTDNKFVGRNRLYVGNLTSDTTDDDLREMFKPYGEIGDIFSNPEKNFTFLRLDYYQNAEKAKRALDGSLRKGRVLRVRFAPNAIVRVTNLNQFVSNELLHQSFEIFGPIERAVICVDDRGKHTGEGIVEFAKKSSASACLRLCNEKCFFLTASLRPCLVEPMEVNNDNDGLPDKTLNKKSLEFRHERSVGPRFACLNSFEHEYGSRWKQLHDLFKSKQDSLKRELKMEEDKLEAQMEYARYEQETELLRQELKKRELDNERMKLEWEMREKQAEEIRKREEEYMHRYQNQLLRHEEDMRARQQENDLLMQAKKLNMILDQQEGFGGSNSGFEHFDSPFEVFGNNSNNSTMAGPGGPDNSDGNQHGHIDSWGHRRF", "length": 630 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q2PRK7-1", "protein_name": "Odorant receptor 106-10", "gene_name": "or80a10", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MANETFVKNVDSFIITGFDHLQNQKLLGSLILISYMFILLGNGINLCIISTDRHLHKPMYILICNLAVVDIMYSSTCSTTMISVLLAEIKTVSYYSCISRTYFFNLGDLTECMALTLMAIDRLIAINLPLRYHSFVTNSRILWLIFLTWIFSFAVIGFLTYVADTLPYCQPIIKYVFCSYSSLVRAACVDPEPYFAISTVYSMVTLCGLFPFILCTYAVLAYSVTKLANSSRKQMINTCLSHIIVLFSFYLPKIVYILLTRIGLVLTLTERNAVLIVSCFVSLLVNPTVYCIRTKGIRKRITDIFLYTQKITK", "length": 313 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q2YDJ5-1", "protein_name": "Uncharacterized protein CXorf66 homolog", "gene_name": "", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MNLFIYVLLLSIWTSSCLDRNESNGSATAVTTHAEFKQTKLQELRRRLLIIVIGTLITGYMVSCTCLLHYSCDSEEAHTAAKDKKEDITIKASRSSKISFTDSKSPTAGLGDPERQSVVSRIDKSSGPSSPRKVPSSAEKLVRPSSQKKPSKPSAPKKVLGSPPQEKLHRTRSPKKAHRQAHAHKPVSQVSPSYPEKAIKSTWPPSLQCRAKPTKTPLPYPKNQSFPEQSSVDKLTKRQRYLKLKCPASAGRAEILSRPHPVKFCRCYKEKCLVCRAVSEPFITHVSDANKKHVPVPLFSRELKHFYKSYKKKQPKYNTLYGNMSDSDITTYNSDGESDREVIIMCNIKCKEDIYKNSRNN", "length": 361 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q3L180-1", "protein_name": "Alpha-defensin 26", "gene_name": "Defa26", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTLVLLSALFLLAFQVQADPIQNTDEETNTEVQPQEEDQAVSVSFGNPEGSDLQEESLRDLGCYCRKRGCTRRERINGTCRKGHLMYTLCCL", "length": 93 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q3TR54-1", "protein_name": "Gasdermin-C4", "gene_name": "Gsdmc4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGYSFDRASKDVVKKLQGRDLRPVECLSDATKFRLFHILQETPRSGWETEDIPVGFTLLDLLEPNFPVPEPEVSAPKPFIHVQSTDLEANLNVADIARGGVGYVGYGGYNIEVQSTSIPNPKLEILQNRKLLDKLPTFMKFCRMERKNLYVVTEAYEVSKDTMLTGLSSVNLLVKGFFKQLFKVRGKAGRSEKYSIPIPKGSVLAYKKQQLVIENNTCVILPSATKKKMTFPDRPLKLYDLPVTLRYQEEVIETGSWIDDIDPIGTIEEPANLNFMCLQHEVSEQTQLLAELSKDVQEVVFSSFLHMLSDRDVLYDLMKMLELNQLGHMDGPGGKILDELRKDSSTPHDVLKDLNLYLLQALLVLSDTQLCLLAQSVKMGLLPHQVELVKSILQTNFKYSSNTPFTLQPQLLAPLQGEGLAITYELLEECGLKMELNNPRSTWDLEAKMPLSALYGSLSFLQQLQKANSSSKPSLSPGYI", "length": 480 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q3U0I6-1", "protein_name": "Endoregulin", "gene_name": "Erln", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGQMVPPRSIQNEDFWKNPWDVGGLTVIGLFTSTFLLFVLFAVVFGYVEKAVFEEE", "length": 56 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q3URS2-1", "protein_name": "Zinc finger and SCAN domain containing protein 4F", "gene_name": "Zscan4f", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASQQAPAKDLQTNNLEFTPTDSSGVQWAEDISNSPSAQLNFSPSNNGCWATQELQSLWKMFNSWLQPEKQTKEQMISQLVLEQFLLTGHCKDKYALTEKWKASGSDMRRFMESLTDECLKPPVMVHVSMQGQEALFSENMPLKEVIKLLKQQQSATRPTPDNEQMPVDTTQDRLLATGQENSENECNNSCNATEANVGESCSGNEMDSLLIMQKEQHPEHEEGNVVCQFPHGARRASQGTPSHHVDFPSAPTTADVPMEEQPKDLSRENISEDKNNCYNTSRNAATQVYSGDNIPRNKSDSLFINKRIYHPEPEVGDIPYGVPQDSTRASQGTSTCLQESLGECFSEKDPREVPGLQSRQEQLISDPVLLGKNHEANLPCESHQKRFCRDAKLYKCEECSRMFKHARSLSSHQRTHLNKKSELLCVTCQKMFKRVSDRRTHEIIHMPEKPFKCSTCEKSFSHKTNLKSHEMIHTGEMPYVCSLCSRRFRQSSTYHRHLRNYHRSD", "length": 506 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q3ZCQ0-1", "protein_name": "Required for drug-induced death protein 1", "gene_name": "", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTVGARLRSKASSLVGRGPLGRLRRAGDEETDAIVEHLEGEDEDPESQDCEREEDGRRAGTPSARRVHLAALPERYDSLEEPAPGDKPKKRYRRKLKKYGKNVGKAISKGCRYIVIGLQGFAAAYSAPFGVATSVVSFVR", "length": 140 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4JEI3-1", "protein_name": "Defensin alpha 3", "gene_name": "Defa3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTLTLLTTLLLLALHTQAESPQGCTEDQKLLIMEDQDISISFTGDKGTALQDADVKSGVICNCRPRGCSFKERVYGECGYNGHILRLCCQPLNTMNKKSPSVI", "length": 104 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4JEI6-1", "protein_name": "Defensin alpha 8", "gene_name": "Defa8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKTLVLLSALVLLAFQVQADHIQEAEEETKTEEQPADEDQDMSVSFEGPEASALQNLEIGWPLKQCHCRKFCRPYEKAEGSCRPGLFIKRKICCIQQWTPGRT", "length": 103 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4KL71-1", "protein_name": "Small proline-rich protein 2A3", "gene_name": "Sprr2a3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSYYQQQCNQPCRPPPVCPPPKCPEPCPPQVWPGPCRPVMCFEPCLPSVWPGPCRPVVCYEQCPPQPWQSTCPPVQFPPCQQK", "length": 83 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q504N7-1", "protein_name": "Pyrin and HIN domain-containing protein 1-like", "gene_name": "Ifi214", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVNEYKRIVLLTGLMGINDHDFRMVKSLLSKELKLNKMQDEYDRVKIADLMEDKFPKDAGVVQLIKLYKQIPGLGDIANKLKNEKAKAKRKGKGKRKTAAKRQRQEEPSTSQPMSTTNEDAEPESGRSTPDTQVAQLSLPTASRRNQAIQISPTIASSSGQTSSRSSETLQSIIQSPETPTRSSSRILDPPVSLGTAYSSAQALGVLLATPAKRQRLKNVPKEPSEENGYQQGSKKVMVLKVTEPFAYDMKGEKMFHATVATETEFFRVKVFDIVLKEKFIPNKVLTISNYVGCNGFINIYSASSVSEVNDGEPMNIPLSLRKSANRTPKINYLCSKRRGIFVNGVFTVCKKEERGYYICYEIGDDTGMMEVEVYGRLTNIACNPGDKLRLML", "length": 393 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54B59-1", "protein_name": "O-methyltransferase 12", "gene_name": "omt12", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSDWDKTMDLLFGFVTGHIHSRMFETILKFSICDLLEDGPKHYSEISKIIGFKNESYCYRLMRYFVPYKLFNESVVQVGLFSKTPSSTQFSKNGTLKNLGRFHCQDHHYRIFESLPKTLEMGKNQGPSSIGLSSFWEHFETDESYKQLFHNAMKDYTSLIIDRLISKISLSPNFKTVVDIGGSHGFLIGKLLESNPNIHGINFDLENIINSSTSKNENFQHPRLKHVSGDFFNSVPEADCYILKYILHDWSDEKCITILNNIHKSLKPNGKLFINDLVLDPSNYTKEAVFKDILMMQYFDAKERSINEWHQLFEKCGFKIDSVDTSISPQLMIVSKINSSNINLNDCTNFNSEIVEEKLKNSLPQFVNC", "length": 369 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54B60-1", "protein_name": "Probable inactive O-methyltransferase 11", "gene_name": "omt11", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MECSESLELVDKFACGHILSRMFNVVMKHSICDLLEDGPKHYSEISKIIGFKDDSYCYRLMRYFVPRKLFKESVVQVGVFSKTPFSTEFSNNGTLKKLAKFHCNSFHYKLSQVLPETLEIGENQGPSSIGLSDYWEQIEKNEIYKNEFNDGMIGYTTHILKFLKGKIDLSKFETVVDIGGSHGYLIGSLLDRYPNVNGINFDTDMVINSSNEKYQHPRLKHVAGDFFKSVPEADCYLMKLILRCFSDEKCCELLKIISKSMKSNAKIIILDIILDSSKYLNFDTYLDILMMETLDGKQRSLSEWIKLFEMSGFKIDKYESGSPNYLIISKE", "length": 331 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54B86-1", "protein_name": "Hly-III related family protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPRLDHKKNKEEKDNEPLMMVNNYNIGIQTDNNQEDIQNDYHHFNDLSINIKNNKNNNNNNNKCNSLHHKHYHNRFIINGGNNNNDNNNNNNGDDCCANIELFVDLMLSENEYILSGFRLHTKNSYMECTKSIFKLHNDTLNIWSHLLGALFYLVLFFTSIIKIIKLNNNDGGGGGGIGNNFILNSDEIKLLETIDLPSNFNYLFFQLSCFICFLSSTIYHTYRSHSIVVFKTTLMLDVASIALLILSSVCLIIDSELSCWPYFKRIYLFSFLILILISFLSLPKIMREKRYGLRTFLFAILALQGLVGHLFKIYLQGYFDKDPNQFYNLIGAYTLFGLALSIRRFKVPESFKPGHFDVWVNITFNIVYNII", "length": 372 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54BG8-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIKIMTWNCQGCSTIKSMNQTKNTINLIKPDISILTETNLKKDQNLAQIKNHYSTGGKGKEARGKGVMAINHLEQIEIKNLEEKEGRILKFTAILNNMEINIICIYAPASYDRRKGWFSNNISLEDLEQADIVTGDFNINKYAKIKFKDGSSDKRKFTENETIEFLMMEVGLTEILPNSTTKTTFKDKLIDRTFLSTKMHQLNHSYKIIDKINKSDHNIVVMDFKIPNFTKIYKSPLWKMNSIIIKEDKTIKKIEKIIDHYQETKRKNINITEYWIKFKKKIKKQCITTEKKRILERKKTLSNLANEHTKTKNKYEKETISNEITILQEEERIDRMIKSSINYINNKEIASNLLTSILKKRDSSSQIHRIKNPSNGKIETEQKEITDCFRKYYETLFKEKECDQETHTELLSTWNPPIDKKKLTEMEDRIEEYEVKLAIEKIAEGKSPGEDGITSSFYKIHQHKLIPILTELFNFFLNNEIPTEFKNGILTSIYKGKGDVLEISNRRPITLLNVDYKIYSKIINNRILKILPNIISKYQNGFIPGRLLHNNIIALDLAMEKSDRNTIITFYDFEKAFDSISHKALIRTLNHLKFPRKITNTILSMLTNTNIRVMVNGQLSESFRAGRGTKQGDPISPTLFAIVCECLSTSIRKDNTIIGIKLNQNNSMKIGQYADDTVTLASNIDDADKMDMKVIKFCQATAAKINDNKCVCITKNPKIKTKYKTIGAKEEERYLGFFFNRKGVISKVDDTVNKLENLTKCYSSVSSTLKGRITILKSYLLSQLTFQLYINEINDIKKLENVNANMLFKGDRWAISKERSRRDYEIGGLELWNMATRSNAQKAWIYEQYLREKDDQNCPPHMEVWKSEKENSLSRIHIKCWKAWKLLHHPRERITLKLNQVKPKYENKQKLKVIYRNMMDIKYKGWNKHQPTTGQKLIQKNINHPILPFREARSITTIKGRDLAWRYLLKALPKHHGENCHSCKEEESSMHIFFECKSIKQNIDSIYQKVCKDSNNTYHGPWSEKVLGKLLTPFSSNLIGAIMESIWYRRNQIKFNDNTTIITENQIIHKIKKARDAEWDRTRKIVEKQLRQELRCTDNRESINRTASIKRRLEKFSHNWNSKLMTINIPEHFIPYCSYNTNYS", "length": 1144 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54C66-1", "protein_name": "RING-type domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MYKTKKYKNPFPTNSYKEPENDSDNEYILHNEEDNEDYGSNNNNINNDGFSYEDNIENSDTEDEREDYGYINYNTNNEEDDEPIDLSTPIKKKKANNKSFKPPYKNTTTTTTTTTTTPPTPPPSKSNNNNNNNNNNNNNNNNNKNKENINKESEYELNKFLDLYNDFKSESDNKVKPTATTTTTTTTTTSTSTSKLNKDKKGVIVIESDEEKEDNTIKINKRNGKRKEGEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQGNEDNLKSENFNKFKKLKSFSNQPTPLPPMLSNPFLNNSGNSHNNNNNRILFNSQFTNASNLNNNINNNINNNINNNINNNINNNINNRNNNTNNYTNNNNNNNNNNNNTNNNNSNNNINNNNYNNNNNNSFSFLPIRSNTLPTIVTRRTGIQSSSSDNGNSNSNHSSSMNKRNTSKSNNKKSTTTTKTVLPPPLSSRTQEEEDYALALSISEGLNGGSGGGSGSGSGSSDNSTKTKRSKSENDLPNEETRHQVEMDRRFAEQLHREQHENINQIQQLQRRLHLNQQRTNNINRNHHGDEDEEDIEMLNLRAYQQIQQQFNQHFNQQLNQLANHPLANLFSHASRGRGRGARRIPHHPHHHHHPHQAQYLTGLSQEQLNLMTRDFSSNDYELLLQLDENINNKGATTSDIENLPVHTLNKPTATTTSTTTTTNSSTSDDNKKNEPTTDVTCCICLCEMEPGDAVRTLPCKHFFHVSCIDQWLKVNKVCPIDKKAIDEK", "length": 766 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54CY8-1", "protein_name": "Obg-like ATPase homolog", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIKGIKLFNNFTNTKQILFFRSFSTAAKGDRLKASHYVKTRGSCKSISIVGLPNIGKSTFFNALTSSNAAMAANFPFCTIDPNIGKVFVPDERLDYISDLLKTKSKIGVQLEFVDVAGLIKGAADGEGLGNKFLGNIRQTSLICHLVRCFEDKGITHVSDEIDPIRDIETIETELILADLQSLEKMLTEGKKKQSNPELQMKFDLVKRISEYLHKGLPARDVEITDMEWPVFHSLHLLTSKPTIYTCNVAEGDAATGNKYTDLVKEYSKSKGLEIEPVVISAKIESELANMEGNDETKKEFLQLYGLENNGLSKVINGAYKLLGLQSYYTASSNECHAWTFKAGWTAPKAAGVIHSDFEKGFIKCDTISYNDFIECKGDEKIAKEKGKQRSEGKAYIVNDGDILFFKFN", "length": 409 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54D44-1", "protein_name": "Probable polyketide synthase 42", "gene_name": "pks42", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIESQREFNCIGGDNQNGVAVIGVGFKIPLDLENCLSSPSELYSALFNEFDSVTKNTSSRWSDNYFKNGDIVSLSAGLLPLREIKSFDPTFFGINPSDADLIDPQQRLLLKCVWNALEDGGIDPISIRSSDTSVYIGCSTIDYFLLNRNPVDPHNHGIQTASYSIPNRISYCFDFRGESLFVDTACSSSLNAVHLGYNSIINLKSKLSIVGGSNLILDPQNSIFFSKQQVNGPSGKCNSFSEEADGFVRSETVGVVVLKNLKDAIKDGDRIYCVIQGSNSNVDGNYEKLNYISPSKLSQAENITKALKSTNGAVNASDIDYFECHGTGTPTGDPIELEGISIALNRTQQSTTLSNPLLIGSIKSNIGHGEASSGIASLIKCCVMFKYRQFLPNINFKTPNPLIKFKEWNLKVVTEPVPFNNNKQTIMAINNFGVSGSNCCIILSEYKSNNNNNNDFKATTHLKSKKFIIPFSSNSSTSLDNYKSLLSNETNNFQDFVIKQINNKSTSLIQRSVIIASNWSEFNESSNEIQSNIKKSIISNITIKKKNAVTVFVFCGQGSQYNKMALSLYENEHIFKSTMDKLDKELSKHYGYSILEKLRSITDEDLVTIHQPILAIPVNVMVQVSLYELYKHWGIKSDIMVGHSFGEIACSYCSGMVDFKTLCYLTYHRSVAQNKTIGSGKMLSINIGAKEYLDSYSTKYPSVEIACYNSETSIVIAGNEELLNEISKDLKSKDIFTAMLPSLSAFHTTHQSVIKDDICSLNFKSTLSKITVFSTVTSNQFGINNNNNNNNNQLNSNYLFQNVIQPVKFSETISNIYKYIESNDMGNEITFIEIAPHPTLQYYLNQMKSQQSEYFNNGEKISIYSACNKKKNDYNEFLKTISTLFVNGYNNINFKSQIINNNNNDNNNNFNLPLYQWDDNEYYKIHPTWKKANKNGPSINHLGNLNDSSIKSFKTYINTRKPQFQWLKGHSLKGKVVFPGMGYISNLLSVYNMNQDITINEIQFKSAFILVDGVNNCLETSIVPLTKNEFNIKFHFKDLKTNKWVLCANANYSLFKHNDNNDKLDIEKLKSNCNYTIISKDELYNNIRAKSGLIYKGLFQGVKEAFIGNRCSLTVLSLNEIENQQEFKHLLENRNFNSLFNTAILDSCLHGSLHSKEQSQIYFDKCEGFKYYSNNINLATSKRNEYKEINVYIETNPVINSTVIVSLKIMLPDGTLLIEIQKVVCKSSIPIIDSTSVIQPSPKDLHTPYYQPKNSLIKPPQSFKHLHCMKEFASIESDNREMVYMSIYHLIFKAINARSPTKINLESLENLTLDQFKELIKDSAANIQRSNQFIYECLKLYHTNHSNYKKNQIKDFIKECEDFNGYNQIIFKTIKIYAKSLFPLPDDDPFTDTIQSLFEDDQLENVYIHLKHLYPVNNLLSEIVFQSIKPIINQTSTFRILEIGAGYGTISQLIFDKLEQLLADNFTSSRIDIEYTFTDISNTFLPRAKERYSKYKRFNIIYKLLDLELPLTEGIQDFRPLYYDIVVMSNVLHVVKDINFSTNEIYKVLKQNGQLIFVEPTYKNLYLDTIFGIFPQWWSFNDDIRTDRCCLEPSKWFEFLETINFKDTIILGQDNKEILKNVENSIILVQTRKPSQLELSINNSPSTNQFKSFENIILYTDDNQQPNDCSEIIDLLKSLELPIKIINNIDQFNQIIKTQYNNNNNNNNNNNNNNNNNNNNTNNNLIIFLKSVNQLNTNNYKDITFEYVQINQILVKLELEENYKLLLITNNSQSSNYLSNSLIGTSRYLFADIVSSKLDIITIDFDTVSIKNHQNVISVINHLLDSKDNSEREYYIINNEINIERYKNESNIKHQLKSKTFQENKDELMVQLDSNLEYRLKSKSKQELKSTHVEIQVKAIGINYKDYATYSGLIDSIIEIDKDKEKDENYDQNYPSIGNDFSGVITRIGSDVRKFKVGDEVCGLAPKTSASHIITEEGYLCKKPSNISHSEAASSVTVYTTSFQSIYSIGDLKKNETILIHSGSGGIGLSALEILKWKNHQGYIFATVGSEDKVKYLTDTYGSFITGIYSSRDKDYQDQIKEKLKSLGCDIDHQGVDLILNTLSVEYMDSNFKCLNQKGRCIDLSITHLTPFDYMDYNKFKFNVSYGNIELVVLPSKIIKDHLKKMLKAFSLGSLRFIPIVEFSNLNIRNAVEYINQRKHIGKIVVKNDVDFINKLFIEQQQQQNSVENNEILMKDKYDISNLELGKNILLTGQTGIILTILKWLYKHSNNSIENIIIISKSKLKWELELFINESTNNRIKIHYKQADVGNNNELNQCFEELRLRHSIEDINSIFHFAFINDIGQFEDVNMNRMDIAHHAKAIGSLNLHNQSIERKWNIKQFVLASSALSVFGGDNQCCYISACSVLDSLSKYRKSIGLPSLSINFGGVTSTGFVSRSGAVEANLESSIINLITPQSLISSLDLFIQNSQTFSNYTHFNFIYDNIESYSLNRMLFKFDYLINQHSSLVSNKRLGGINENNNIGDLLVSKIGELLSIEPSKLNLDFRLVDYGLDSLVIVQLKNFIDKQFQPHLISILQLQNNKISTTIEIIIKGYNNNQNKKIKNEQSNDIPSVVQKETIKDNNENKDDIKIDMDDKKENLKGKKENIDDKKENNN", "length": 2655 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54E06-1", "protein_name": "Transmembrane protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTIINNDNISLATSAKLSQFIVSGDYKGPFTIIGLKTKILSFSLVIEFILLKIELIKERKDGLKINFDDSISGSCNYELNYTKQDTLFQRFQSKFKIEHTINPENGETINTGITLKKLFIISIPMSILFVALNWIWMLAISMTEVSISTALYLKILKTISVIIFMGGIVGIAITTVGTSKGEYPHAIKGEILMIISAAMWGLYEVLTSKFIGDANRTIVHTYMGLIAFVNLILGIPVIVILNVTNFEPFSVPSISVFGMLLLNAFVGFSVNYLINWGLSVTSPLFVRSGELMVIVATLLFDIIIKHMKLPLLALPGYSLIVIGFILSVYIESRDIKQQQEKEKEKQKNNNGETESLLNY", "length": 359 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54EC9-1", "protein_name": "DUF781 family protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLNKIILIFFLINNIFSIVVSSTKLNPWVFEERIKLYDILINSTKVEIFGDDNLNNCFQGFKIQLEWQKTTGRSMIIDNSNISVNSWWGSMNYYESIIPFISAMNLGIIQPPIELVNIGDDRFCTDYSECDKELMEPWDLYFQFLIKIKDEKYSYSIQQQILKYNWDGHMKSLSIGLKLFNDKLNYLSKNEIKFSTGFVHFVDIISLINFNTNYSQILPIFDSLPPRMLTNSDHPPFFKGFTRTQNFYTVSVLSINELHENQILWNYFLNLLKTKTENEKCRDFINQEIINFTKYPESTLVKLLLKLLLNNC", "length": 312 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54ED6-1", "protein_name": "Probable polyketide synthase 41", "gene_name": "pks41", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDSKNLVDENCNKVAIIGIGFRFPNLKGDITPNELWSKLLNRYDGIVKNDRWNESFFKSGDISTNYAGFIPFEELKSFDPLFFGINPSEGIHMCPQQRLLLKCTWEALEDSGIDPIEIRGSNTSVFIGCSGADYQNLNKNDNKVQQEIFSSSTHSISNRVSYCFDLHGESMTIDTACSSSSNAIRRGYKSIIDGSSNISVVGGINILLDPNISKSYSRLNILSKDGKCKSFDAGADGYVRSDAAGIAILKNLNDAIKDDNNIYCVIDGSASNVDGNGFSDKSNFYSPSKSSQVECIRLALESTNGQVNENDIVYFEAHGTGTPTGDPIELESVSIALKTSENRSSDNPLLIGSFKPNIGHTESASGISSLIKCCLILKNQCFVPNLNFNKPNPLIKFDQWNLKVVTDPIDFSTLNYINKRVSIAINNFGVTGSNCCLIVSSFKGNQIRNNINNKSKSPKQYLIPFSTNSIKSLDLYKSRIDNNVEFKEFAENQIKSKSKKLIQRSVVIASNWDEFNLKSNTINTSNDKLTSNMLVSSNKKNVTMVFVFCGQGAQYSTMAKNLYDNEPIFKKSMDKIDSKLNEYYGFSILEKLRSFNENDLKGIQYSIIAQPSTCMVQISLFELYCHWGIKPSIIVGHSLGEISSSYCSGMIDLDTFCYLIYHRSMVQSKTNGLGRMLSISIGENEYNSKYSSRYPELEIACYNSPSSIVIAGKELILNEIIKELKKDGVFCAILGSPTSFHTSSQLSVKDEILKISFKSKQPTIPIFSTVTTNLYDEMNPFDTKYVYDNIINPVRFTNTISNIYKHIELNYSVNNNSNEVIFIEIAPHPTLSFYLKQMVPEDKKQSVSIFSPLSKKKSNDLFEIQKLISELYCLGYNGIGFNIQLSDHNNTNNQTRVNLPLYQWEDQEYWKLDNLHQYHLSNGPSINHLGISNSNHTPIKSYQTHINIQKKPFQWLKGHQIKGKYYFPGCGYIDNILKIFGESKTDTNPNKELPDILISFIEFKTPLIFMDGISQCLQTNIHSTGKKEYKALFHFKDEKSSSDWVQTSTANFQLFSRGPNLNEDDEQSLFMYNINDLISNQCNLTKLSKQELYSHIKTKCGLNYSGDFQRVDKCYLGYNCSLSEISIIQGVNENRSTFFDSSIIDCCLHGSIGLIDENCQLVFEKLEELTYYSSKVPKTTSQHSKIYVYSKLKPRIGDSYSASIIVMLENGTVLFEMENASFKSTTKIKDPLAMEYPTNEIYSCNLQSKDSLIPSLSSFDHIFKRKIPNEYVDQINIYESFIPKLLFSNINKRCPEITIDEIQSSEIEQLLLKYYKIKEDNDNKWLSRLFTFAFESIKQWYHNEDYDFENVLSPHNFKIFSKSTKIISKLLFPLENDNDEDSPQSLFEGGLLDKFYSSGFSAQNELVGEIIQESIKPILNEKLVFRILEFGGGVGSLSLLVLEKINSLLIQYPNYQIDIEYTWSDISPSFITEAKAKFEKFNDRFNIIYKALNLEQPLIGEKQGLKPQYFDYIIMFNVLHVIKDVKYGVEQIYQLLVPNGHLLFIEPIYKSIIGDGIFGVFDQWWSFQDTEIRKDRCCMKQKTWYKLLKSVNFNDDIRMTPELTCFVIQAQKPSISNLSFSKSETTNYDSIIVFGNKYASNLSNHFIKSIDNGNLQFISTIEELNKIGKYISNESIIYFIKSIDELSVDNFVNITHEYTQINQKLMELNCKCKHVLITNDSTTTNYLSSSLIGAARYYHECPLELFILNFDTPSIIENQNLFKTIEPLINSSINIQREFIINNHKVYYERIKNETKLKSIFKNSSSFESLEQVDNFMISLTPNLEYKVKVKPTSILKENEVEIKVMSTGLNYKDYLIYAGLVESVEPIFGIEFSGIITRISTGSKEFKVGDHVYGIGKSTTSSHIITDIDVISHKPSNISHSEASSIPVVYLTSYHSLYNIGALKNNETILIHSATGGVGLSTLEILKWKGHSGLIFVTVGSNEKEEYLRENYGDMISGIYSTRNKNFVKQIKSKISKLNPFGKSGVDFILNTLSSSDYMDSNFKCLNMSGRIVDLSITHLNSNEFTDNKKFKYNYGYHNIELQYVDKKIIKSTLSIISNAVSSNDLQLIPITHYSIEKVKESIEFINERVHMGKIIINHENQDSIINELIEKQKSINKFDQSIFKQNYKLEPSLLGRNILLTGQSGIVLEILKWILRNSENNSIGNIIILSKSSIKWEMEYLINKVKLINKLGNFFNNIKFHFKSVDISDSGLIDESINKLLIENPDINNIDSIFHFAYTQATCNSDEVDLHHLTQSHSAKSMGAINLHNQSIKRNWKLKNFIMSSSVSSKTSTANQCGYISSNNVLDALSKYRISIGLPTICTNYGLIESTGFVSRNESVAALLSGEGFIPISANLILGTLDLQLQNQAQSSNLILSNFNFTSLNGLPQKSLISKFDYQININEENEKSKSLLKDDNVELTVDQLITFKISEILSTDILKLNKDIILVDYGIDSLVIIQLKNWVDKEFSIPNELTIQKIQNSTINSFIQLVKNSMDKNKK", "length": 2542 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54ED7-1", "protein_name": "Probable polyketide synthase 40", "gene_name": "pks40", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDYKNKYQSNENCNKVAIIGIGFRFPNLKGDLTPNGLWSQLLNKYDGIVKNDRWNESFYKTGDIPTKYAGLIPFEELKSFDPLFFGINPSEVIHMCPQQRILLKCTWEALEDSGIDPIEIRDSNTSVFLGCSNFDYQNLNKNNNKIQQNIFASSSHSVSNRISYCFDLHGESMTIDTACSSSSNAIRRGYKSIIDGSSNISVVGGINILLDPNTSKSYSQLNMLGKDGKCKTFDADADGYVRSESAGIAILKNLNDAIKDGNNIYCVIDGSASNVDGNGFSDKSNFYSPSKSSQVECIRLALESTNGGVNENDIVYFEAHGTGTPTGDPIELESVSIALKTSENRSSNNPLLIGSFKPNIGHSECASGISSLIKCCLILKNQCFVPNINYNKPNPNIKFNQWNLKVVTDPIDFSTLKLSNKPISIAINNFGVTGSNCCLIVSSFKGNQTNNNNNKSKSPKQYLIPFSTNSIKSLDLYKSRIDNNVEFKEFAENQIKSKSKKLIQRSVAIASNWDEFNLKSNTINTSNDKLTSNMLVSSNKKNATMVFVFCGQGAQYSTMAKNLYDNEPIFKKSMDKIDSKLSEYYGFSILEKLRSFNENDLKGIQYSIIAQPSTCMVQISLFELYCHWGIKPSIIVGHSLGEISSSYCSGMIDLDTFCYLIYHRSMVQSKTNGLGRMLSISIGENEYNSKYSSRYPELEIACYNSPSSIVIAGKELILNEIIKELKQDGVFCTILGSPTSFHTSSQIPVKDEILKISFKSKQSTYPIFSTVTTNLYDEMNPFDTKYVYDNIINPVRFTNTISNIYKHIELNYSVNNNSNEIIFIEIAPHPTLSFYLKQMVPEDKKQSVSIFSPLSKKKSNDLFEIQKLISELYCLGYNGIGFNIQLSNLNENDNIQTSLSLPLYQWEEQEYWKLDSLYQHHLSNGPSINHLGISNSNHTPYIKSYQTHIDIQKKPFQWLKGHQIKGKYYFPGCGYIDNILKIFGDNSESTTNPNKELPDILISFIEFKTPLIFMDGVNQCLQTNIHSTGKKEYKALFHFKDEKSSSDWVQTSTANFQLFSRGQGLNEDDEESLFKYNINDLISNQCNLTKLSKQELYSHIKTKCGLNYSGDFQRVEKCYFGNNCSLSELSLSQGVNENRSTFFDSSIIDCCLHGSIGLIDENCQLVFEKLEGLTYYSSKVPTTTSQHSKIYVYSKLKPRIGDSYSASIIVMLENGTVLFEMENASFKSTTKIKDSLAMEYPTNEIYSCYLQSKDSLIPSLSSFDHIFKRKITDEYVDQIKIYESFIPKLLFSNINKRCPEITIAEIQSSEIEQLLLKYYKIKEDNDNKWLSRLFTFAFESIKQWYHNEDYDFENVLSPHNFKIFSKSTKIISKLLFPLENDNDEDSPQSLFEGGLLDKFYSSGFSAQNELVGEIIQESIKPILNEKLVFRILEFGGGVGSLSLLVLEKINSLLIQYPNYQIDIEYTWSDISPSFITEAKAKFEKFNDRVNIIYKALNLEQPLIGEKQGLKPQYFDYIIMFNVLHVIKDVKYGVEQIYQLLVPNGHLLFIEPIYKSIVGDGIFGVFDQWWSFQDTEIRKDRCCMNQQTWYKLLKSVNFNDDIKMTPELTCFVIQAQKPSISNLSFSKSETTNYNNIIVFGNKDDSNLSNNFIKSIDNGNLQFISTIEEFNKMTKYISNESIIYFIKSIDELSVDNFVNITHEYTQINQKLMELNSKCKHVLITNDSTTTNYLSSSLIGAARYYHECPLELFILNFDTPSIIENQNLFKTIEPLINSSINIQREFIINNHKVYYERIKNETKLKSIFKNSSSFESLEQVDNFMISLTPNLEYKVKVKPTSILKENEVEIKVMSTGLNYKDYLIYAGLVESVEPIFGIEFSGIITNIGSGNKEFKVGDSVYGTGKSTTSSHIITDIDVISHKPSNISHSEASSIPVVYLTSYHSLYNIGALKNNETILIHSATGGVGLSTLEILKWKGHSGLIFVTVGSNEKEEYLRENYGDMISGIYSTRNKNFVKQIKSKISKLNPFGKSGVDFILNTLSSSDYMDSNFKCLNMSGRIVDLSITHLNSNEFTDNKKFKYNYGYHNIELQYVDKKIIKSTLSIISNAVSSNDLQLIPITEYSIENVKDSIEFINERVHMGKIVVDHENQDSIINELIEKQKSIDKFDQSIFKQNYKLEPSLLGKNILITGQSGIVLEILKWILRNSENNSIDNIIILSKSSIKWEMELLINKTKLLNSNSINSMGNYLNKIKFHFKSVDISDSGLTDKGIHELLIENPDINNIDSIFHFAYTQATCNSDEVDLHHLTQSHSAKSMGAINLHNQSIKRNWKIINFIMSSSITSKTSSANQCGYISSNNVLDALSKYRISIGLPTICTNYGLIQSTGFVSRNESVAALLSGEGLLPISTNLILGTLDLQLQNQAQSSNLILSNFNFTSLNGLPQKSLISKFDYQININEENEKSKSLLKDDNVELTVDQLITFKISELLSTDILKLNKDIILVDYGVDSLVIIQLKNWVDKEFSIPNALTIQQVQNSTINSFIQLVKNSIDKKNKK", "length": 2552 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54EN3-1", "protein_name": "Alkyl transferase", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSNCSNNSENCNINDNKKKEENVKNQNSNKNSNNNNNKSNIESIILNKKSKFSSEKELDEKENKDLKDLSNNKPINIDEYEGLPRFENEQNARSKSSLWSKLCDWMYDQNFKIASSTLKNGPIPKHIGVIMDGNRRFAERNHLETKEGHKKGFNTMLDLCQWGLTLGVKIISVYAFSIENFKRSKSEVQDLMELANNKFTEMISKSHKLQQLGVRIRVVGDHSHIPEKTKSILAKAVKSTENNTKALLNICLSYTSHEEILHSMKILSKGVNQEKKIEIEDIDQDLFENCLYIKEDLDILIRTSGEYRLSDFMLWQSCFTNLALVNTLWPDFSFFHFIYIIFLYQFNSKTLKNEIQNQYKFNNNNNNNTDNNNNLKENIKNLKSDQRVKEFINHLKISEEKLFDEFISKYNEEEEEEEEI", "length": 420 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54F52-1", "protein_name": "Saposin B domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLIFIVCLLLIFNYFIGISFGNKQINSNQQQQIINTDKNYNHNKNNKIIVSHNKNNNNNNNYNEIETENLGCTFCKYLTEKVEEYLQANSTEKEIISYLDEECELLNSPNLVLTCQNLVQQYTPIVIELIDNNESPSVICENVNICPTSSSSSSSSSIEEEIIKKLNIDDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNEEEEVNTCEICNLVSNLIEKYIKINNEVDEIRELIENECELLSNSKVSSCYSLVDQYFEHFYVTIENNYSANEICQLFQFCPIESSSSSSSSDIINNIPLQDSGCTVCTVLANYAYKVQANESIPEIIGSMDEICNKIGAWRDICNSIMRSGGQQLVEDIVNKGEGVYTACSNIGYCQSSSSATGTSGFSSGGSGTSTGGGYSTGDFYYKPLK", "length": 416 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54GT5-1", "protein_name": "Endoplasmic reticulum junction formation protein lunapark", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGNLFSKKNGFEKQLLDMETKILNLEDKLSNSRIFHQKVLHKIVLYSFAIEFFIILFTYVKSRSLESIPEKLFCCIYLVLFPIFILILTKVYGFVYKYLIKKNEVRLDSLKTGLQKKLDERKRETDYENTQKLLDRYEKNPPSPTNKPLGPPNLNNNNNNNNNNNNNNNNNNNNNNNNTLGNSMRNRNQPFNISSQQNQQQQRMIQPQQLSPQQLQLLQQQQRLSQQIVPSQQQQSQSQPQQQQPILNQPYNINNNNNNNKPPPPIQLPPQQSSQYIGNQQRLPPQQYQNEQKSKWWLDKLVDYLISDGPTHGSPLICSNCHSHNGYVPVEELSNIQFRCRVCKTFNQRDSVNNSTTNDDRNNSQNTGSNQQQSQSLQDQQPSIEEIDKNFSVTEQKNETNNENYSDSEKQLEENNNNNNIDNDSGSSSSQNTPNKKKGKGKGKGTPTKKTN", "length": 452 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54H60-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLDFFHLKDVDEFFRLLEKKNLQNLDNQIDGPGNLNWRTTYTEKDFSKVPKFRGIIHIVQIRDLGTKIHRDLLYEIMFEKLLDIARLNNESKLLKNEIQDLKTKLDEYHNNNSTTNTDLIINSFINVIDTTTTTTTTKTTMGATSIDKKQSEGDSIDKSIELDFFKIKSDQSQQSSPSHKLEEKQNQVNNITNEIPQESIKTVKQQTQTETNQQTFSSTSPSHQNEEKQDKQEEVKQEEVKQKEGIQKEDKKEEDKKEEGKQKYGEIFIIEIPQEEEKQKEEGKQQDGENFIIEIPQEEDKQKEDKKEEDKKEDKQEEDKQKEEKLEDKQKNGEEFIIEIPQNETLEIKVDTHPRSSNDDVSTAEMEVEALKTPLFAETTFVTKQQVITNKKLLVYKQSDFFPNMTTLLQSRLKDVTVQEVKDLTKIGLNDNSYSVGDFENVFVLYAVSCMGARTDSERDAFKIKSIRSIIGDKVPIIYGVFMIGKNGPTRIKVEHTQTSISITHSMSDIGRNLQNNENLKQLQSFLQQ", "length": 529 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54H72-1", "protein_name": "Tudor domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSNIDFEDYEFYDDSDFEINTVDESVMTYSSVFDFLRFGKIPKFDTQTKMKHFKDNISKYRIESKDILHTNVDSKILRRLSEIPRVEKIFPDPNTLQLEVFKPNHELRNSNGELLSKHRPLQETLKLIEKQYYWECKFIHTSMEVDITKLYSFCDLCSQSSVSRDMDIDSNDEDKILEQMDIVEKSFSNDRNNNNNNDDNNKSIDEKDKMNICGIGIDLEAIKEGKLFEDELAEALGFPEYNSSVDNSFNSSVNNSNLNNSSLNNSLNNSKNNNNNDDDNNNNNNNNNDDNNNNNNNNNNNNNIISNIDNNNNNNNNNNNISNIDNSNNNNNNNNNNNNPVNDDFSFIIPKDYQSKNHLNDNENKDDEKDDDKDDDKDDDKDDKDDDKDDDKDDDKDDSKDNGYIKTNVSLSSSSSSDNERDDGDSHSDKSVDNDENNNNNINNIISDCNNNNNNNNNNNKINGRTFTSRRTRSDSNTSNSSVGSYISNSSKSSANSYDFSSSDQDYKSPNSPTVKKTRGASLVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNINNSILKPKLKSKRASASTAINSFISQFITPKHPPKSSSRLKRANRSNDSSDSGDSSSNNSSRSSSDSSDNENNNSYYLPIQSRRSTSKQILKDHLKSPTKKPRRIIEEDFYHVEEKKSPTSKISTPISRSASYNFGRSSPGSSPGSSPSLSPYSSPPQSPPHVYNHNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNYNNNNNNNNNIRSILKSPQSPSISPIKTPRRSPQQQQQLQLQLQNYIPMPTKTKTPTKAPYVPNYALAPIEPKPTQKTPVHVFGGNQLSVKKRQTIEDMITEVLKMNVDTAALKLPLPKVGQHVEGKSNMEDYKDAWFKGVVKEVLPNDFFLISYIDGGEEELSYTRLKPNLTSELEPLKLEEIVVGGEYLGSYRNFYYNVYVLEILRHSIRVYFADLEMAKTIKYSQLYLLSSFVKR", "length": 998 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54HE0-1", "protein_name": "Conserved oligomeric Golgi complex subunit 5", "gene_name": "cog5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNNNNNNNEGVSSSSSSSSSPLPNISSPNLISNSNIENDIEIKKKSNNNNNNIFEGDNSHIYNQFLGEDFNVVHYTSNALKVSSISLSLNTLTSCTRELGQELTENITTNYDDLFKLANNIKELDQLTDTLKLGVSNLEESIQRMKNDISEPYNKVKSHIGQLKRVQDSCELLRKLIRYIQLVKKLKNHLQAGSRDLSKSAQCINEINLLKKDSDLTGINIIDSQVVWIKTCSDQIITISSTLLYQGMENQNQTDVANSLQVFHNMTILNEKVYSIVNLTTEKVIKNIKALLNVNKLIADLPKTTITNNINNNNSNNNITTNNNNNNYNNNNNNNNNNNIISTSTDKSIWLKFESLIDTLYSSLIQILHLQRVLLKIKDPLTHKSLMEVLLIKQHQLQQQQQQQQQQQQQQQQQQQQQQQQQQQVGTTSNNTQPILIEMISTLFWKSILKVLENNLLVAAKSSNIIENTFIREYPKVSKFFLDFIKKLQNYIDIHQMDIQQQFMIVLSNINQIIGNNNSNNSNSNSNNSIESSLSTSSSSSSSSSSSSSTTTTATTSLILLSADDYKLSLFKSIGLFEKAYLEYSQSKMSTIVNGLFPQSTWSSRSTLPVIPNGKQLVDLSKTIWSEIEWLVGNNDRQLLGKLMLVVSKVIDLFSSKIESMVQPPGLIVLNSNIGSSSSTGGVNNNSNSNNNNEIITINENSKPTPSQTVNTLLFNVSIQLNSSIQSLLTSQPLERESIIVIEKSLNSLITICTNIITPLMNSFFTHIEQIFSTIHNEDWYNEKTTKMLINKSNQTCSSYMESFKTLVNYFQNQYLMRFTPCQLLNNQIKSMISKIFIVYLKYCSLLKQPFSENGKLKMVNDLTHLEFAVTPLLVSGGIKEIGESYNLIRNYKQSIFN", "length": 898 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54IX3-1", "protein_name": "Probable polyketide synthase 26", "gene_name": "pks26", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "METNNNKNIQEDIAIIGFRIPGCQDNTPSELWNNLMNKFSGVGKTTERWSDNYHLSGDINNGNSGLLPLKEWKKFDPAFFGINPTMVSTIDPQQRILLKCTWEALEDAGIDPIKLRGSNTSIFIGCSTGDYLDMVKSNNEIQTNLFGSVNHSLSNRISYCFDFHGASMTIDSACSSSLNTVLLGCQSINQGKSNLCIAGGVNFILDTTIPTAFSFLNILSKNGKCMTYDEGADGFVRGEGAGLVVLKSLKDAIKDGNNIYCIIKGGNTNVDGNGNADKANFFQPSKQSQSDNIKLALESIKKKSMLDIDIDYVETHGTGTPTGDPIEVEGISKVFKENHSPENPLLIGSLKSNIGHMEAASGVTSLIKCCLMFKNKSFAPNVNFQKINPKIKLDEWNIKVVTEAIPFKKNKITSMVVNSFGVTGSNCCLVLTESINNNNNSNVDKITKNEKEYLIPFSANSNQSLKNYIEEVSKIDESLQFEDFVYKQLSNKSTSLFQRFVVTSKDWKELKYKLSQPLPLKEISSSISVKKPNPITVFVFCGQGSQFNKMGLELYNNDKNFRNYIDRFDKKLLEYYGYSVISKLRSIDDNDLITIHDPIIAQPATAILQISLFELYKHWGINPSFIVGHSLGELPMAFCSGMIDFDTVCYLLYHRSLAQSKTNGCGKMLSCNISSEEFVKNYSPRYPFLEIACYNSPNSIVVAGKESILLELSKEFKNSGIFCAMLGSLSSFHTSSQLEVKDHIYSLKFESKEPVIPTFSTVTTHLFNSNKLYDNDYIFQNIMKPVLFNETISNLYKHVENNQLGSEMIFIELAPHQTLSFYLKQLIPKDSNYFSNSNSITILSPLHKKKNDYLEIQQTISTCYCKGYDVNFKSQILIESKTNISNKSLPLYQWDDKEFWKDLEKQKRILQGPPMDTLGFSNEKSPILKSFETKIDIKKKPFQYLKGHIVKGKIYFPGVGYIENLLKMYPSQDIDIDSMEFEAPLILIEGIVTCLQSNVYKIGKNEFKVQFHFQDQKTKQWIQSSFANYHLSHRDDFDPTTNKLNIQNLISNNCNLTKLSKNQFYNFIKAKAGLSYNGEFQGVEKCYLGDNCSLVEIPFDTSNQDVETNINMIPILDSCLHGVHILYVEQCQMVLEKIEGLKYYSSTLILSKQKEQQKLYVFTRIENKDLINNSISASIIVMISDGTVFFEIESVSLKSLIPLKDPISIENPTDELFSSYLQSIDSLISEPSSYKSIYKRNEFISSGMSDLSRSDYQQFISTLLYTNLIKRNQSIESDLRNQIEFEEIKAKYCKNSKFERLFTFVIETIKQYDGINGNLNSWNEGNIDIYKILIKSTRIISKLLFPLQGEDTTIDTPQSLFENNLLDDFYNINGNTVIQNQLVGEIITQSIKPLINEKMVFRILEFGGGVGSLSIVTLNKINQLLEQHPNFQIDIEYTWTDISPSFIPDAKKLLSNIKGVTIIYRSLDLEESLIEKQLLKPSYYDFVIMSNVLHVIKEIKFGIDEIYKVLSPNGQLLFIETPYRMLICDSIFGVFDQWWGFTDTGIRVDRCCMKQKTWFKLLSESNYQDIIMSDDIKDCCFVIQAKKPSISSLEYKLKIDSQENDKIIVFGENDTFMKYLENKSTKQIIKIKTCQQFSDLITSNSKEINNQSIIYFIKTLNQLLIENFKEITLEYIQINQLLLSSGLSCKHILLLNQSTSENYLGSSISGAARYFDEFPPLKLYSFDFDKYSLNNESINIIDDIIEPIIKSMNNSNIRKELLVRNNKIFFERYKQEKRIKENYKSTSFENDKSLFVHLNANLEYELKSKQVKLKQNEIEVNVKATGINYKDYLVYTAMTPSELINHKGESNPEFGHDFSGIITRIGDDDGDNDNEFKVGDQVYGIWFNTTASHIIVDKEFLCHKPSKLSHTIASSIPVVYITSLYSLYNIGNIQNDESILIHSASGGIGLSALNILKWKNHKSHIFVTVGSKEKEKYIHDTYGDFITGIYSSRNKDYLKLIKRKLTELGSNKKGVDIILNTLSSSEHMVSNFKCLNHRGRIIDLSITHLNHNEYTCNNNFKYNYGYHNVEVLFVKGDIISKLLKNITSAIENGSLSTGIPIIEFNDSDCFNAIEFINKRQHIGKIVVNHNKENLIQELIKKTNLPIIKSNYQINSDHLGKNILVTGQSGIILEILKWIVKYSTNVENIIILSRSSLKWELELLVNKNKNKLNFIYKSVDVGNSLEIEKVIDEILMENPQINNVDSIFHYAFTQISCKEHEIDQVHLNVSHQAKTMGAINLHNQSIKRNWKLINFIMASSAAGLIGSTDQCSYVCSSNVLDTFSKYRKHVLGLPSICINYGLIESTGFVSRNQSVAVMLDGQGIRPMQTNQILGSLDLFIQNPSKSTNIILTSFNFNEFATGNLQQSNVHKFDFQFNCCLSQKSKLMANNQASENPVKDLLINNICELLSIDESKLNIDIRLIDYGSDSLTIVQIKNLIDKNLLIPNLISIQMLQNNSISDNIKILTDSYNKKKQNEQNELKNIKVGSFTKK", "length": 2531 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54K45-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTKILYLIIYLTLTIVKGAPLYNCKKLNCSSMNTNCKVFGCSPMFGCFETSKCPQSNVDICHTNHCDENTGSCYQIADTCNDGNNNTIDSCGPYGCVNTPVNPPEPTQSCEQKCNDNNPCTVDFCDFRGDCYHYETRCSDYDACTLDTCGEKGCEYRPMNCDDNNPCTADFCSMLYGCYHEPIECSVKVPCRTDSQCNRNNFCETYSCDLSSNICDYYTRDCGGNPCINNECRTGTITN", "length": 239 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54K50-1", "protein_name": "Phospholipase D Y", "gene_name": "pldY", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIINRLFIIIVLFFVNVNSKIISESTLNSCQGGTIQIAESIPLGLDISTNLSTHDAWMDLITNAQESIDLGFFYFTLLGGSDLDPVYGGQLGIDIFNAIVEAHSRGINVRIVQNEPSESFPDTETQTLAKLGIQVRSIDWVSLVGSGVLHTKLIIIDESSAYVGSANADWSSLAQVKELGIVLKNCPTMVADTEIAFQQYWNAADFTSLPINDWGSNYQALFNNTNMASLSLNNNNNNNNKNKNNDNDGSGTNQMYEMFLAVSPPQFQSTYRTGDIDALMDAINNADQSICITVMDYTPTTLYNDPNTYWPLIDNALRAAAFNRNVQVRMLISHWNYTSPIIPQWLHSLNQVDNIQVRWFVVPDFSTNPQIPYTRVNHAKFMVTEKQSYVGTSNWSQDYFTVTGGLSYNVFNNDFTNQLQSIFNRDWNSPYTQPIQNF", "length": 438 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54K65-1", "protein_name": "Band 7 domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNSIKKLSTTAIKFTKQTQRFNKRGFFKILNQYERGVVFNFGKFHTVKEAGFHIVIPFIQKCDIVDIRTFTYTLDKQKIISKDNINLTVDALVVFRIHDPKLAVTKANDCILLVNEMAQIKVCEILSHNTLDQVLHNRDKISNQIHDELKEALNKYGVTIEYLKLKDIHFDETIAKAIAKKVEAANLRDIKN", "length": 192 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54KF5-1", "protein_name": "Protein LEG1 homolog", "gene_name": "leg1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKSNKTIFLILLFLINFNSIYSFNFKKEIKISNDKINLPTYNPWIFQDRFNLYSILINSTNIPVFGEDNSNNCLHGLQLQFEWQNRSGRLEINQGHVNTKSWWGDMNYYLSIIPYLSAMKMGLVPVVEIVSINDQRFCSTYEDCDQEVLNNWDNFFQQIINIRNNGSEGDDQQLLKFMWTAHIGSIDKATKLFTDSLLLLPKNELRFGNGWAHFVDVIATVNFNTNYSTVYHLGQQLPPIMLNSNDTHPSSIESFTKEQRNVVLTMYEINDLSSNNLVWNSFMYLLKKMTKNEICRNLINNEINIFLNSPVPTIIEILFDILTNNC", "length": 326 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54KK9-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTEVPNQKHNDGGVGVTVGNFVKDNETNVNNNNNINGKGENDNNNNNNNNTIIDEPKLLNNNNNNILVIPLTTNIIDNELNQQKQHTLPLPLPPPPLPTQPQQITPPLPTQTQLPNNMLPSPRPIQQPKIRQQTQQQQAQMQQLQLQIQQEIQLQLQQQQQQQLQLQQKQNESEINGLFSPNFSSSSSSSLSTTPNMHSPLFNNNNNNNTTTTTTTTTTTTNSSTNNTNSSTQTKNASTNKISQDVIGVFDDTDTESEGEEYHSGRSIDFWNKDYKDIAWRCNWIDLQIRDLQYQSMVCDQLYHKVRRSKQKIIPDNKSLSSSIDNNNNNNLKSIPIETIDHSNNAITSSNIPYSNNEEEQQEQQQHPSQSIRTTSVVKLRKPRKLIRRPTVKLSAKQMTTDLEAHPLFTFHKGYFKFENAIKTNIINEMEIKYQEKEKPPKLLTLSEERLKQYINSNEDVDVVNLFATNESKRLSEKRRGRIPSDKKEKVSSHRLKSGDEIDGTSSSTATATTATTTTTTTTTTTTTNKKSRRSRREKKKEKEREKQEKEKHIKTKDEQKDREKKEKAREKELEKERKREKERIKEKERQEKERLKKEKELEKNKKKEKKLLKEKEKEIKEKKVKLKNQENIIEKDLTINNTTTKTTKSKKSSSKVKKSEQEGVKLENVEIEDEEVEEEEEEEEEVEDEEEEEEEEEEEEEEEEEEIEEVEDNEEEKRKEERRRRRRKRRILRRRKKLRRKQRKRQLFLQKQQQQQLLQQQQQQQQQKLLQQLKKRDESNGLSYKEIITPEWRDISSFANNDPSLPSPLLLSNPLLAQDIKNITTTTTTITTSEPISKFSTITEEELLIRQTTNGIDGTPMNGIGEDSESSGSEIELDEDAMKIIHARNEIEEKRRFFNTIKQIQMENPVPSYKRKKESLPVEFVAPTVEELLPSYHFNKKSIKLLGKSWNGDFEYYSSSDEDDYDDSDDYDSDDDNDDEDDDDSDSDDEDESDSDDYDSEYDSDLSDSDDSESESSDNELDGLYSSESEINHNSSGDEDEMDVELNNHHIPSKNSKNSKKQPVNNNVNNSNNLNGSSGGGKINSKPSKQQPRNSKANPPSKQQPTPLKQQPTPLKQQPTPLKQTTTPSKATPSPKQQSQQQQQQQQQQQQQPQQPQQPQQQQQQSPKPTPPLVSTTPPLSSVPLSPPTKTIRSTRGVSSLSNSTSSLPKQTNTPPISILSRKRNQSQSSVTDAPLSPTTTATTTTSPKPTTRRKGKLQETIPVEETKIIEETKPFEETVPIKENSTTTPLKRTRRQTKQQLVNGETTTPLTNGDNHVEKTDSNSTDVKVDPTSWWGDKQYKIQPVMEATVIRFKRVKNDDGDDDDQIQNNQKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNINNINNTEDLESKIKETKSINIPMEISTNGNDFQMKEKEGE", "length": 1472 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54KU3-1", "protein_name": "Probable polyketide synthase 25", "gene_name": "pks25", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDNSYLNNPQFDINNGNKEVTDDDNNKNNQDNLVAIVGVGFRLPSGENERNNTPQALWNNLINGFDGVVKTSERFNDNFFKNHEIANNYSGLLPLDEVKSFDPLFFGITPNEAQTIDPHQRLLLKCTWEALEDSLIDPISIKGTDTSVFIGSSTNDYLTLNRNEVKSNVFGSMAHSIANRVSYCYDLHGNSITLDTACSSSLNAIALGYDSIKNKKSKMSIVGGVNILLDPYPYKAFSILNMLSKSNGRCKSFDASADGFVRGECIGVVILKNLKDAIKDGNRIYCTINGASANVDGIGYSDKSNFYSPSSISQSENLKNAIQSTNGTVKPSDIDYVEAHGTGTPNGDPVETEGISKVFKDTRSTDTPLLIGSFKSNIGHCEAASGIASLIKCCLMYKNKCFAPNIHFKTPNPAIKFKEWNLKVVTEPIPFNENKNTSMIINNFGVTGSNCCLVLSQFNNTNKQKQQMKTKINNYLIPFSANSVESLKKYQSLIINSKENELKYSFEEFVKNQVFIKPTSLYQRSVIVAKDWNDFNNVENQVKYQTSSSTSSNITITNKNNNPITVFVFCGQGSQYNTMALELYKNEKVFRNSMDMLDNKMKNYFGYSILEKLRAIQDSDKRSVHEQTMAQPSTVIIQVSLYELYKHWGIKASFMLGHSLGEVTTAYCSGMIDIDQLCYLIYHRSTLQIRTNGLGKMLSINISSDEYKTNYMSRYPTIEIACYNSPSSIVIAGNEQILNEISKELKEKEIFSAMLGSLSSFHTSSQNIIKDDILNLNIQSSQPVIPTFSTVTSNLFNESTIFDSEYFFDNISKPVSFTQTISNLYKHIEDNQIGSNIVFIEIAPHPTLSFYLKQMIPKQSQYFRNGESISVYSTLHKKKNDVEEFQKSISQLFCDDAYDINFKCQFNNINSNIEAISNFNLPLYQWDDQHYWLNKSIEHKNNLIGPPISILGNSMQDSNPFIKSYQTIIDTGKDAFKYLKGHNVSDKCYFPGAGYIDNLLKLYPNQDLTINSIEFKTPLILSDDNGQFLQTNVYQTGKSDYRAQFHFKDNRTNVWVQTCTANFQLYNNGKVDKLNLEEIKSTKCNLSSIPWDKFYPHIKNRTGLNYKDKFQNTIECYLGDNCSLTEISLELPENFHDQESFFNTPILDICFHGSIVLIKDNCKLVLDKIDGFKLYTSNIPKNRFDHLSIFVYTTMKSTKSNSYNSTYTVMLEDGTVILEVENLICTSLTPVKDPLLIEIPTDMYYTPYLQSKDSQIQSPLEFKSIYQNNQDNDSLLIPNVVLETIKPLINEQMEFRILEFGGNNLSNSTLLLNSINSLLEENPHYEIDIEYTWSDNNSSILKDAKLELSKVDKGYLSILYRSLGLDVDNSLLEKQKLNPSYYDLIIVSNISNLTKDIKYSLNQIYQILTPNGNLIINEQQPNNENNENNEDSLKNLLVNCNFNSDIMMKSSSVSDSDIKSIIIQAQKPSLKLQPKTINTFDQVILYCNQDEQFQQQQQLINKFESHYNNNCKIIKVSTIEEFYKLSTTITNNSIIYFIKSIEQLTLENFKSITFEYVQINQKLYEFKSKCTHVLITYDSQSSNYLSSSILGAARYFDEIPTLQLFTFDFDKDSLINLDISVIDHLIDPKQNTLIEFFIKKNGKVYFERFKKGLKKNSFKSESYHQITNEQEILISKLDENLDYQLKSKDSILKPYDIEVEIKATGLNYKDYLVYSGLIKLKGDSVDFGLDFSGRVSRVGIKSSKEFKVGDEVYGIGQSTSSSHIIIDSMHACHKPSKITHVQAASIPAVYATSIHSLYNIGNLREGESILIHSGSGGVGLSALEILKSNNHSSPIFVTVGSEEKKQYLINTYGNLITGIYSTRDTNYQKQIKNKLIELGYETHGVDLIINTLSSEFMDSNFKCLNPEGRIVDLTITHLNPNEFIDNNKFKYNFGYHNIELYYCEKPTIKKLLQSISKSIENNTLNYLIPITEFSNSNIKKAIEYINERKHVGKIVISHDTDITNKLIENQPKIDYSLLKSNYKIKNLGKNVLVTGQTGLILDIINWIMKYNSTVENIIILSKSSMKWEMEFLINNNKTKIKFYYKRCDIGGDSDSINKTFDKLFTENPTITNIDSIFHFAVVQITRKVKDIDMKSLNISHDAKTIGAINLHNQSIKRDWKLSNFILASSILSKVGSLDQCGYVSACCVLDSFSKYRLSIGLPALSINIGAMGGSGMVARSELVETVLNGQGYNLTSTNQLLGTIDLLIQNPGQESNNLMVGNFNFPVFNNFKQKIHQKFDFIFNALDSNSENGDGSNIKNSTNIKDKFLNKVSEFLSIDSSKINNDIKLMNYGADSLITVQLKNWVDKEWSPNLITIHQIQSNSIGMVCQIINDNFEKKK", "length": 2380 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54KU5-1", "protein_name": "Probable polyketide synthase 24", "gene_name": "pks24", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKQNKINKAEILQVDDKHVEENLVAIVGVGFRLPSGSIENERNNTPQTLWNNLINGFDGVVKTSERFNDNFFKNHEIANNYSGLLPLDEVKSFDPLFFGINPNEAPTIDPIQRLLLKCTWEALEDSLIDPISIKGTDTSVFIGCTESDYHNINKNEVKSNVFSSLNHAISNRISYCYDLHGNSITLDTACSSSLNAIALGYDSIKNKKSKMSIVGGVNILLDSYFFKAYSSLNILSKSNGRCKSFDASADGYVRSECIGVVVLKNLKDAIKDGNRIYCTINGASANVDGIGYSDKSNFYSPSSISQSENLKNAIQSTNGTVKPSDIDYVEAHGTGTPTGDPIEVEGISKVFKDTRSTDTPLLIGSFKSNIGHCEAASGIASLIKCCLMYKNKCFAPNIHFKTPNPAIKFKEWNLKVVTEPIPFNKFKNTSMVVNNFGATGSNCCLVLSQFNYNTINNNINNHNNNHNHNHNHNNIKINNYLIPFSANSVESLKKYQSLIIENKEYESQYSFEEFVKNQIYNKSTSLYQRSVIVAKDWNDFNNVENQVKYQTSSSTSSNITITNKNNNPITVFVFCGQGSQYNTMALELYKNEKVFRNSMDMLDNKMKNYFGYSILEKLRAIQDSDKCSVHEQTMAQPSTVIIQVSLYELYKHWGIKASFMLGHSLGEVTTAYCSGMIDIDQLCYLIYHRSTLQIRTNGSGKMLSINISSDEYKTNYMSRYPTIEIACYNSPSSIVIAGNEQILNEISKELKEKEIFSAMLGSLSSFHTSSQNIIKDDILNLNIQSSQPVIPTFSTVTSNLFNESTIFDSEYFFDNISKPVSFTQTISNLYKHIEDNQIGSNIVFIEIAPHPTLSFYLKQMIPKQSQYFRNGESISVYSTLHKKKNDVEEFQKSISQLFCDDAYDINFKCQFNNINSNIEAISNFNLPLYQWDDQHYWLNKSIEHKNNLIGPPISILGNSMQDSNPFIKSYQTIIDTGKDAFKYLKGHNVSDKCYFPGTGYIDNIFKLYPNQDLTINSIEFKVPFVLTDGIGQCLQTNVYQTGKSEYRAQFHLKDEMNNQWINTSNSNFHLNSNDNYHEEKQKLDIQDIKQTKCNLSSIPWDEFYSLMKTQLGANFYGIFSKVVECYIGDNCSLTEISLELPENFHDEQSFFNCPLIDACFHGTVILYIQKNCKIVTDKVEGLRYYASNIPKNRDEHSSIFIYSTLKSSPSDDLLSSSIVVMLEDGTVIIEVDNLVVKSLTPVKDPLLIETPSDFIYTPYLQSKDSQIQSPLEFKSIYQNNQVDDGLLIPNVVIETIKPLINRKMEFRILEFGGNNLSKSTLLLNEINSLLEENPHYEIDIEYTWSDNNSSILKDAKLELSKVDKGYLSILYRSLGLDVDNSLLEKQKLNPSYYDLIIVSNISNLTKDIEYSLNQIYQILTPNGYLIINEQQQQQQQQQQQQQQQQQQQQQLLNNENNKESLKNLLVNCNFNSDIMIKSSSISDSDIKSIIIQAQKPSLKLQPKTINTFDQVILYCYQDEQLQQQQLINKFENHYNNCKIIKVSTIEEFYKLSTTITNNSIIYFIKSIEQLTLENFKSVTFEYVQINQKLYELKSKCTHVLITCDSQSSNYLSSSVLGAARYFDEIPTLQLFTLDFDKDSLTNDLDLFKTIDYLINPKNNIQREFYIKNSGTVYFEMYKKELKNLKNSYKSESYHDLSKQQDQLVSKLDEHFEYQLNSKQIDLEPYEIEVKVKATGINYKDYLKYNEMIKVNEAGIGFDFSGVVSRVGIKSSKEFKVGDQVYGIAYETSSSHIIIDSLLACHKPSKITHVQAASIPAVYSTSLYCLYDVGNLRDEESVLIHSGSGGVGLSGLEILKSNNHSSPIFVTVGSEEKKQYLINTYGDLITGIYSTRDTNYQKQIKNKLIELGYETHGVDLIINTLSSEFMDTNFKCLNPKGRIVDLTTTHLNPNEFIDNSRYRYNIGYNSIEILKVGKSTIKKLLQSISKSIENETLNALIPITEFSNSNIKKSIESIKERKHVGKIVISHDTDIIDKLIEKESMIDYSILKSDYKIKNLGKNVLVTGQTGLILEVLKWITKYNSTVENIIILSKSSLKWELEFLMNYNNNNNNNNNNNKIKYHFKKCDISNWNLINKTIDQVLKDNPTITNIDSIFHFAALQINKKLKDIDMNSLNVSHSAKTFGAVNLHNLSIKRDWKIINFILASSVVSVLGSFDQCSYVSACCVVDSLSQYRKSIGLPSFTINIGGVSDRGYLSRHKLVEAVLGGQGVELISPNQLLGTLDLQIQNPNMPTNAFVNNFNWPLFKSFKQKLHQKFDFILNPINVDNSISMENDTNQSSSSTNVKNKFLNKVSELLSIDPSKINTNIKMINYGADSLITVQLKNWVDKEWSPHLITIQQIQSNSIGMVYQIINDSLDKKKKEMDEKLLPITAKTTTTTKNDPNDKTEYKYIAGGDCCREFSIKFHYSSVVNFII", "length": 2471 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54LI2-1", "protein_name": "DNA replication licensing factor MCM2", "gene_name": "mcm2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSQNNNNNNNNNNNNNNNNNNKRKTKTPSSVNHNNTKINEDKDLYNFIDKIRDKTDKSHLEDEYDEDDNTKDGKFNKVEDEIKNDIDSEEDDDDIIEDNEHLYDGDEDSENLSSEGEGDDLLDEDLQDQDEEEVLGDEDNHYEMEGLDNETYEDIDKDKKTEVDSILTKRDREEQKTRQATNRHQYRISSFLLDENDENMVDEDTENNKLLEKRKANLIKKRRETIRQQNDNIKKDYDGSVPSFKDGFVNSERYFEDGDGDDDDDDDDFDIGDNGQVVNLEEPDKDKCLREYVCMSGPRNEISKQFAKFLLEFKEKDGFNPIYQESIQKMCAANKESLMINFTHLCASTVFGVWVAEIPTEMIEIFDEVALKVVLRIYPNYRNIVKSIHVRITHLPICESLRDIRQSNLNKLTKVGGVITRRSNVYPQLKHVKYDCVKCKTTLGPFSLDGTFNDSKPPIGLCPQCQSKGPFVMNSEQTVYRDFQKVTLQESPGTVPPGRLPRTKDIILMDDLIDTVRPGEEVEITGIYKHNFDLKLNYSQGFPVFSTIIEANHINKKEDLLSSFILTDEDEREIRKLSKDSNIAQKIIQSIAPSIYGHEDIKTGLALALFGGTPKDVNNKHRIRGDINVLLIGDPGVAKSQFLKYVEKTAHRAVYTTGQGASAVGLTAAVRMDPLTREWTLEGGALVLADRGVCMIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLTARCSVIAAANPKRGKYDSGLNLLQNVELTEPILSRFDIICVVKDTIDSFKDRELARFVVASHINSHPDNQNNPENDYLNRATKQSPISQELLRKYIIYAKRIKPRITDIDKNKISQLYTDLRRESRAGGFAMTVRHVESIVRMAEAHAKMHLRDYVTDFDVNTSIRVMLDSFINAQKNSMYKNLRTKFAPYVIFQKDINQLLTQLLQTLARDFSNYHFARSGDIPDQINIPYDDFDTKARELGISDITSFFRSNEFTSNNQFTLKKDKSTIIYYRNK", "length": 1008 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54LX5-1", "protein_name": "U1-type domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKITESNNNNNNNKKDNNKHWCKYCKIFIQDNISVKNHEEGWRHKNNVTRFVSTQNRDKKYQERDQKEAEREINRIKNTGARSFREKDLSRVLDEKKHQQQPQQQPQQPQQQQRIFNNNSNNNNNNNNNNNNNNNNNNNNNNNSNNNNNYHQPQYPTTTTTTTTTNTTASNKNCDNADSKFKEIQEQQRQLLSNNDYYNYYQDRQQLIYDYYQNEGNQPIPEPPLNTSLYGYTESPLLKSRLDSSTDTLSSSSSSTIISPSHQKKRKQDDTNSPIPAKISKDECVNNENKDKSNEKENELNNNNNNNKSGEGEEGEESDDNDDDEEESGSGSESESESSEVDQSESIIGQWQTVDPIESAFGSTRKDSDDEKDKKDKKNKKDNDENKRDEKDYSDVSDADSEEESVNITKRAMANHKKPITLTNVISPTIPSTSKNFESVLSFNKSGVFSLNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNEPPQPTPQITLKFNKPLKQRNTRKTNIEDKQS", "length": 514 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54M95-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLISILFFLFGILFFLKNVESASDVVCSFGYQACGNNCYSPSSGQKCYPGGVVCSFGYEACGNNCYSPSSGQKCNPGGVICSFGYQACGNSCYSPSSGQKCYPGGIICSFGYEACGRSCYSPSSGQKCYPGGVICSFGYQACGNTCYNPSAGQRCFN", "length": 158 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54N59-1", "protein_name": "G domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDLDYAIIVLRHHLESNGRFFEISKDDVKNRVTIKNKLTQEERYIDFGEIQNFIQYDEFEYNLLANGFQENLSILKNSILPLTKAPDSCSSNRGKTIGNSSLLINKVNGLIDDDKDTIYLLLIGITGVGKSTFVNMVVNYIEYSNLKDALENATLEQIYTIASKIEIQDENKTHKFSLGDVEDYKIGSSVTQYSRQYRIKLPDGKTLCLIDAPGVGDPQGTLQDNKHFENILHEISSLKKLNAICILMRPDETRATVLFKYCLNQLLLHLHSSAKDNIFFCFTHTRGTMYKPGPTRAILEDHLKKMKDQSDIEINANEKTFCFDNESFNYLAVKKYNATAGIETNFSEDDEFDFGRSWDRSSKEFKRLLEEISKVQPHDVANTICINNARTMISNLAQPMSTCISNINTNIKLMEQQSEKLRNNSIGDESLLYIPVSVVIAEKLENSLLVCTKNGCSSNTDNPCNIDVVSPKWYSSLYWCDNINKMGTCKKCSNTGVLPCLWFDHQVVTIKETPQLNQLPGTDKKTIGQRTKSEIFNERELLVTKMGERKIQFQEEYDTIKTAIVDFSVFLWHHSLIKFNRYYEDYINMQIKQLENSENSQELIQKLNEHLSEYKASVEEIKHNVQNNKASVKTQKEIFATFDKLLTLPNVGYIIQNQIKLKQSSHYKSEAVEIDLFSKMKNKTKQIIK", "length": 689 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54ND5-1", "protein_name": "Multiple inositol polyphosphate phosphatase 1", "gene_name": "mipp1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MMVKIKNIIILFCIFGLLSNVSSLSSSSSSSQSSDNNGNLSPIQDYDLEFLSKHLTTKTPYWILTKNGDSNSQGDGSSGNSNSNSNSNSNSNSNSDSSNEPPEQCKLISIDFIARHGSRMPVLNSIEKLKEMTTSILEYKEQVNQGFNWIFNYSVPYPSDIAGNLILQGQYEHYNISKRLLKKYPLFFEPMKYKPQSYSITSTAISRTGISASAFSYGLLQGTGSLGVDGFQPVFIETASLDQDILLRFFATCNQYVDQLKNGTLINKDEQTKWNQMVFPNISNEISERLGLSDIWLPTSNVISDIFEACAYEISINNISDHWCSLLSKQNILDWEYSQDLSNYWLKSYGHEINYQIATPLLNDILSGFDIYINNNNNGSSSSSSSSSSNNGDNSGSNGSSGSGSSTSTSSNDNGSTNNNDNKVEPTSILRFGHAETIIPFISLLGLYKDEQKLFANSSTEQIENRKFRTSVVSPYASNIAMFLFDCGSAADGFKILVQHNELPVLVPGCDEIYCDYQQFKSIFKQGIDNFKWNSYCNINDDDSGSSGGDSGNGNGNDSHSKKSSYFLAIFIPITFLVGGTIGGIFTYFSYEKIMQVKNRKKLTQYGNDEFISSPKSKSFSFKPTKFDSRSPLIQ", "length": 635 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54NT2-1", "protein_name": "SH3 domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSNKITTQFARTRQMLFTKTGHSEETIDVQYHYEKERTFSTEERLVKIQKNSKKLIELYKDLNKITTDIAQDACDLYDTQDPMWTPGSKLRDVATNNDKHLLDYTEQMAEPYTKPLSDYISQYKEARKRTEELTTRKVDMDRYKNEVGKLREKGAGSSSKAKLAPTEEKLRICKEGYDSLHEELLNDLPRLNEDKLIFIDYLVASLIKYQSEFHKKVSYEWSPLPSLTKHVDEYSGRDHQPVITSVERSAASINLRSDPVFKSNASIKMKPGAQDQQQYSTVDKDIHQSPNPSNLNLQKSTPNPYGGASAPPPLYGGGGSSTATALYDFTGVDSSELSFRAGDIITIHKSEGEWWEGELNGIYGFAPGSYLRMN", "length": 374 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54PW0-1", "protein_name": "Annexin I", "gene_name": "nxnB", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEYKEKEINTSSPSSPSKTQISNIENDSISEKAQEPISEKVQDPISEKAQESISEKEHIESNNVSEIIDLIKSGDQHLNNNNNNNNNNNNNNNNNNNEEENQEINYNDNQLSNEEIVEDVKNSNINNNNTIEKGNSSQNNNKNNNNNYHTEKCDYCLICKCYDYGEITHNIVEDSEILKQSIRYSYVDDTSINSILAHRNYAEKEAIMKKFNDKYNKSLETELASHTHQKYRRTLISILTEPSIYDTLNIENSIKTKNSNTLLEILLTRTNEQKELIKRIYLVKYGKNIEHDIIAKFSNGANVNGNMMKQLLISMLNNDRDSNSNQSLDMNLINTDSNRLYQAGEHKKGTDHEVFIEILSKRSFSHLSELDRVYENSNPKGHSLRKAIELEFGVSKSIKQVKISLLDILLFSKEPSKYWAEQFNRALTSGSWGINEIDLTRLTITQQHQASKIKQAYISHYDNSLINEVSSKTSFRYKKIILSMLTV", "length": 487 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54QB4-1", "protein_name": "Kinetochore protein Ndc80", "gene_name": "ndc80", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MHNNNLTYQQYQQQQLLIQQQQQQLLYQQQLLQQQQQQQQQQQQQKQYSHGRPSTLGLPSRKPPPMQPQPQPQIQAPIQLTFQQQQQLLQQQQYQFNNNLNTINNNNNNNITNRHSMVTPSTNLGGRSSLGPPSAMLTNNNNNNSNIRNTTFISNSGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNIINNNNNNNIHTQVQPKKSIAPSKSNTISSNTTTTTTAASSSSSSNPSITLRQETRPVNDSKFQSQCLLRLQQFLSQSEKGYPRAITKDNLMSEINGLMKFLCLHIDPHFKLPTEKPEEEIISFFKMMGYRSAGFTKRVFSQVGNAHTRGHLLGAIIWMVELIEYDQIIRQMDSHIEREILNGNTIDENGNLTTTTSATNTNEDGNFNLTTQIFSKHVFKSYEAFLKGDDGNHVDQFLEEKFNEVNELIVKECEESMERQKKIKQEIVNLTQYITNDDIDQLNFKLEQTNQEIIATHDLINDNELEDQKLDQEIDQNQTHFQELEIQQKEHQKKKQEFESRIQIQQSNSVDAKRINQETFELKEELDKVQREQSRHDQLKQEKSKEIKQSINEIEKLIQSYKEICCKASLVTNDNLIIEKYRIIFTHTLNNNNNNNNTNNSSILNISNNIINNNNNNNNNNNNNYEEGIISISDLKLVIKNLQELNLEISQNISKIKQDLLKTSNLNDIQKESISDKELELARIKQKHDKQKNILKQEKQDQTFDITQREENIEQLKSSNKKLIDDGVRELEKTIQLLESQREEHSRLKIDLKQSSEQMKLQYLKRIERFISHRQLIGSQIFDTLRQMEELSLTQKILFPPPPPPPQLSQQHQQLMQQQHQNNTIDIDE", "length": 855 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54QD2-1", "protein_name": "Probable cytochrome P450 517A1", "gene_name": "cyp517A1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEIINVFLFLIILFLVKDFVKKNKKIHTKSPSGPIAFPILGNVVQIRFWELFKIQEHELFGGYSKKYNGVVRAWFGERLFFFVSNYDVVKYFQKDENFHNRPSVLVPGWRYASSNGLGVMSSSDDKWKRAKSSVSQSLRVRTTKKLMEEKAIEFIDSLEKISNNNEIFYPKGHIQGYACSMLFKYMFNQDLSVESGMSRTIGNAVEHVFGNLSKLTAFDCFEIFSPLYDWFFTRRLKGCDIVRQIISSQNENHLKSIDPSKPRDLMDDLLIEYGLNEITKEDTMQINQICFDIFGPAVGTVTITMNWVILQLCNRPELQEIAYQEIKKAVKDDEYVNLNHKQNAPYIVAFIKETMRLCSNGFGLPRTAKNDQICGDFFIPKDAIIFINYLEISQNEEIFKNAKEFNPTRYLDESLPVPNIHFGVGQRACPGRFVAIDKMFLGISNLLLKYKLKTQNGEKIDDSIQFSVSLKAKDYGIKLEKRI", "length": 483 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54RM4-1", "protein_name": "Peptidase S8 and S53 domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKVILIYFIVIYLINISFSLKPYQQQQQLHNFNIIENNNNNNRNEKVIIAHPKIPPYWLIENEISNPNDLISFKILLKQNNLNKLNYLFEEISDPKSKIYGEFLSINEINELVKSSESDFNVVLEYLKSFNIGNIENGSEIKVFSDYILVETTIEKVSSMFNSKFSNYKNKNNGNTRNRLNGPAYLPKQLLNSIDFVTGLSEFFENNFKIENYLNNNNKNNGDSDSDSGSGSGSGSSNSYNGGLDDILITPKVLKSYYNVPNELIGKFENNSIGVIAFNDYFSMGALELFDEKFNITTTKDNLKIIGNDCLGKGCDQYESDLDIQYIRSMGENISTDFISFNDAQWILDYLHSVLLMEKPPLVQSISYGWAELLQCDVSNGCSTFGYDSKQYVDRTNSEFQKLALLGISVLVSSGDDGAPSMGGSSGNCPIDGTVYCPTGGCNHTKTMCPEFTIYNLNGGSDSGGSSDSYCFFPMGIASSGCTNILGDPSVLDSGMKIFSEKNKQCNLAIEYDRTNLPHVYSECECKDLVNVTFRNYHFTQYQFNENNGALFVAEYPSSSPFVTSVGATQFLSRDEKITTEVGCTILQGAKITTGGGFSSFQSQPKYQQYAISQFFNTSFNSLPPSFSYCPTNRGVPDISMVGHNYKIYSSDGNNKDFNQCPCKSLPVDGTSCSSPTLAGLIGLINDQLLLNGKTQLGFLNPLLYQMAIDEPRIFNDITGDSSNRCSRSYCCLYGWSTSSNTWDPVTGLGSIDFNLFLSYVLKLKGI", "length": 767 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54RX1-1", "protein_name": "Translationally-controlled tumor protein homolog 2", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLYKDLIGNSHDDLLTDRYEIKVGDVTFEVKTKMITKDLNVVVNNNSLGGSISTTVDNNNSITLSTNLEDEFENVEAAGTFQINNLVEQLRLVETSFDKKSYLAYMKLYIKDLINHIKQQPSNSDNEKIEHIQKGIQSFVKTMMDGENFKKYSFFTGSSMDANGLVALMYYKDDDPTTPTFVFIKYGLLQVDV", "length": 194 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54S19-1", "protein_name": "PHD zinc finger-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKNCIVCSKVGQYPLNLVKCYECKSYYHKFCLQSTKIPRGEWYCSSCEIERKNKKNKKRKLDGAGKKNKKNNKDDDDDNDDDDDEGENDEDDEDHQDEDSGEEEDEEEDEEEEDDDDEEEEEGNEKNKIKKRKRIPINQSPSIKKRTKDIDSEEEEEEEEEEEENDSEEERRIQKRKNKIKQQQQLKMKEKKQREKLRKRRRRTRSSRKDDNDQDDDDDDDDNNSNNSDDNDQDENKNKQKRKRRKDKKKDDDDDDDQEEEEEEEEEIVTGKRKRRSLNKVQPNQHLNNENEEDNEEEEEEEEEEEEEEETDSSEEFLENLVCSSCNTGKDEDKILLCDTDNCSRGYHMYCLRYPITSVPKGDWICDFCRFGDISADLHSADDDEDGAINSQKEIEKQKQKQKEKEKEREREREREKEKEKERERERERREKEKKDALRSSFSNIPIPKINNINGSNGSNSNNNNNSNNNGSGVNRQSPPKVISKKSPQQSPKPLKSPTSSSSSTTSSPPPLHQQSKVTSKISPNSQQSIPTINSNINKSPPSQSKNSPPLKPLTPDLKKQIPITNITTSSTTTTATTTTTTTTTANTSNVATTTTLLKPSSQKKPTILSDKKQLNTSGTNLPMNGKKKEDLESSASHSILDMIPPNNKLFNNSIQSAPISWDLSGSQHKLSTSSSSLPNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIKLQQQLQQQQQQLHQQLQQQQLQQQQQQLHQQLQQQKLKQKQIEEEQEKEREQKRLENEQKLLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQEFIDQKELEDKLLSQFDNQNLKSPLSLTSTTSSTLSHLPQSTFESSTILSNKTIKQKWKSRILFETDQICQCEIIQIYGMDFKVNPFQNNITSKTLELSFNQVSFDNLPKPIRDEFITKSSTPSTCLDIGAIDLPNSALLIFLPEIPNQSSLYHLIIHFIENRVAGFIDLSNDLSLYIYPYQTSIISLDLIGILIDKKSLSPPSLILNQQQKQQKQQQQEQEQQNQSFDIKNICYIGINHISMNKILTSQGKNYFSFSNFNELTLSSDIKNFDLVVVDNKMVNNQTINKEINNLMQLQPTTNNNNNNNDINNNHDTLLLVIKDVEFSKWLVSQKKFPNSLEIQKIFQQQILFKQSRCIFLLDNSIIIENESSYFVEFISSFGKFKNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSSNDWTIKISSTIFDELLPFGHQSNVKKKIDEIKRGINQQLIVSYDFSPMVPKQSSDFLLLALRIAHSKKYKQVFLITSNKIIQNQSKRYSNLNLNCLSLEGGIDYIKNINNKFSLKI", "length": 1361 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54S56-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIAKTQIKCTTIYAPAKSNERHEWYKENLTEEILHSDIITGDFNVDCSVDNNLNKYIKTIFDEFEFTEIKNGITFPRNKSTIDRVFVSKKILHLNPIVTTKEIKLKSDHNMVIIELKIPEYEQQKKGERLWRQNLETLKMNSTSLKINKTIKYYNKKFEENTSKWYKLNICEQWLKLKDEIKKLSINIEIRESNKTKNKLKELAEKLETAKDSRAIFLKEEINNILKEQVRIKQANQTNTHINNKETPSKYLTRRLKVQRKTNEIPQILDPSNNCLVTKHEDILEVARRYYENLYQKRECNEDTHHELLKTFNKRIDQKILDEINQPIEGYEIRLGIEKIQEGKAPGKDGLLPTFYKNHINEILPIISKLYNHFWNTTIPKDFKQGILITIYKNKGDPNNLDNYRPITLLNVDYKIYSKIINNRILKFLNKIISPFQTGFVPRRLLHDNIITLNSTIEIIKREINTKEDMEPIITFYDFEKAFDLFSHNAILRTLAHLKLPLKMVLTIMNLLNESETSVYINNSLSKSFTSKRGTKQGDPISPTIFALVGECMATTIINDRCINGVTKETIKILQFADDTATIAYNFMDHFLMNEWIKKFCQATSAKINQTKCSCITFKWNTRTLYTVIKSNERYLGFDFNNKGIKSKINTISDNIRAKLVTWNSTSSTYMGRLIMAKTYALSQLTFHTYINTTPQHNSIENNIVKFVFNTKSKNSLSLQRRQNNYINGGLNLWNLKTRELAQKAWLFERYLHQRVSNTPSSYIKLWEEELKNNNNNKTTTKQNQLQLHWQCKQAWTQLKTPQNKQTHYEHLPKLKKIYEDMMTTQSPEHNKFIPTPGQKEIMTKINSKHLPFKEIKKIINMKGRDLLWRYTLKALPKIYNMPCQQCGEDETSEHIFFNCKAHIKNTQEIFNYTLTKCGHTTHTWNVKILNHLQIALVANLIAIIFDKIWHKRNKLIHDEKEIIIHRQQVIRELIKTQRAAWDRTQAVINKTLRIKSKQRPEEQNKLDSLISLKLLQFSRQWNSPLHAIELPKHLKKYNNSLSTFYK", "length": 1047 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54SW0-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "NQAKSSTIQQPTQTQQSNINNNTAKPRAAPPLKLVITNSNPSLKQKPQSQQTIPQQSVPQQSIPQQTIQQSVPQQQPNQSQQVNVNRTINPQQQQQQQQQQQQQQQQQNINRTAPLPQQSNYKPQPGVIYQQQQQTQYRVGTPLTINRSPMVGMVSKQPMSSSQQQSQSQQNIQRVPCQGKCCAGLAVKPLVPINSITAKPPPYSTMGPRGPISGGFVRTSPTGAIIGPSPQQQTMSRAMVNSMPIQPQIQIKPKPSPLNNGGIPITTTTTTTTNPLNKSSPSTLTQSSNTLASSNNNITTSNSLSSSTSSLPTTSTTPTTKPKSKPRSKSNSNSQTSSSTTSSSSTPSTPTTNSTKNKENTTPNKGDDSGTDNEKSSLSNSSKLLPTAYTMDQVLPFNPNQMFLGPEDKYIKSATRTYHKIPTNPSVMSNNRGAEIPSSLEYILDIPIIHDEPSSKNNPTWGRLILDALRRLVANKKTTRITERLKLDNMYKDMDSRSNQDKLDWKNGLVNEAQLNYLLSFLSNTIPFPDTPEKNKNKYLSSSDSQIINSNDQSNSLNSNNSSNNSTTNNNNSSTTTNSTNNIINNNNNNNTSSVPNSTNNSNNSSPEQQDVIDMELKLEPDNSMNFPIEINMDSLGSYIDDSFTFDNSSYDDTATISSDDKNLPITTVMPPTTSTTSTPQTITNTIPTTTPTIISPPTITTTTTTTKTTSPPTITTTTSPPTITTTTSPPTITTTTTTINSITPTTSTSSTINSNTTPMLDIVIDPVISLELLDENHQQQQNKEVKEENVHSKQQPPQQQQQQQQQQQQQQQQQQQQQQQQQQQQEDFMIQVQTSDLETQTQIQQDKEEIQVKPIVDSKKSGNSPTQIQQQQQHQQQQHHHQHNTLTQGFEFGMMMDIMNSPSSTSSMKRKRDDVDQPINQINNSSMVVQQNNDFFSDFNTIEAPFSSSHHSSQLSFQTPFSPDIVIDSDFQNKKRIVS", "length": 981 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54T36-1", "protein_name": "Probable polyketide synthase 19", "gene_name": "pks19", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEFGNKEIAIVGIGFRIPQGKESINNGSVSHLWNNLKNGFSGIVETSERWSDNINLLGEVNNKFGGLLPLKEWSDFDPVHFAINPSEVPLMDPQTRLLLKCTWEALEDAFIDPIDIRGSNTSCFIGCSTLDYSTTNRDFNETSENYFASNVLHTISNRLSFSYDIRGPSMTIDTACSSSLNSITMGFQSIQNGTSNLSIVGGASLLLDPYVSKSFSFLNMLSKKGKCKPFDSEADGYIRAESCGIVILKPLSDAIRDGNNIYCVINSFSSNVDGGGLNDKSNFYSPSKQSQSDNIKLALKSANMKASDISFVECHGTGTPTGDPIEVEGVSMALNSSTTSTPSKPLLIGSLKSNIGHCEAASGVASLIKCCLMFKNKHYAPNVNFDQPNPKINFKDWNIKVVTEAIPFTNINEKPVSMVINNFGVTGSNCCLILSQFIEHSISLNGNNPSYPIESQQQIFLIPFSANSVKSLKNYEDLIINDNNLSTNSFKEFVKNQIYSKSKKLYQRSVLISSNWDQLKTKNKYFKTSNDKSSNITIKRNQPLIVIVFGGQGSQWNKMAQQLYECEPIFRSSMDKFNKELSKYYGYSVLDKLRSIKDDDIISIHQPIIAQPSILMLQISLFELYKHWGINVSFIVGHSLGEIATSYCSGMVDFQTVCKLIYHRSISQNNTNGCGKMLSVNISHSEFIELYSNKYPTIEVACYNSPTSIVIAGNENILKEISLDLKENNIFCAFLGSLSSFHTSSQNSTKNEILPLEIPSRQSTIPTFSTVTTNLFNHETTPFNSSYVYENIIQPVRFSQTISNLYQHIENNKLGNELIFIEVSPHPSLSFYLKQMIPKSSSYFNSVSVLTSTNKKNSNDLDEIHSTISQIYCLGYDINFKCQFNHNDDDVNSIRNNSTIILPNYQFDEQYYWKVDINFEQYRLNGPNVFNNLGKSMINYSSNNKSYESIIDINRNPFKYLKDHIVKGKYYFPGIGYADNIMKLYPNKDIVINNLEFLAPFVLKENVKHILQTNVYQLGNTDYRVTFNIKDNKANQWVQTCTGNFQLISLKDNNNNNNNNHSSKYNINQLLSECNFTTLSKQEVYKYSKLRSGITHLGTFQGIEEFHFGNDLTIARIQINYENFDINGKPVYQTFDKSFFNIALLDNCIQAITGFITNSSQFVFERLEGLKVYSENIPTDKLKYKNIYCQAKFISLEADSYKSSVLVLLEDGTKLLEIEHISFRSTLPLIDELLLNNPTNELFTNNLQCKDSLVNILSIDNNETSSSSGSSNTVTEIIKQTIKPIINEKIVFRILQSFSDSELSKQIIEALNQIFDNSLQEIDIEFTIIDNSNDKLPTLHDSSLIFKNDITQLKPSYYDIIINNNNDETIIKPIFNILSSNGLLLLIIEDDIGIRFNINNLIGVGFNENKIQKSNKVIQSQKSTILSNELTVVPNNKNDNIIIYCEKHSKYTNEFKKLISNNHTNRKQTTISNINEFNQLLPSITNDSIIYFIKSMEQLEMNNFKQITMEYIEINQQLLKHSLTCKHVLITIDSQIKNYLSSSIIGASRYFNEFPSLNLYSIDFDNQLSISSLLNKIINQLIENSNNHIQREYIIRNNSIYYEILKNEKNIKSNFNSNSFEDNDFMTLLDSTNLEYKLASKPKKLKKNEIEVKVLATGINYKDYLIYRGLVVIDENVSISKNPLGLEFSGIITRISDENKNCEFKVGDNVFGVSHDATASHVITDVLYVSHKPNNISHIEAASLPIIFSTCLHGMFNIGNFNIDDDEVILIHSATGGIGLATLEILKWKGHKSPIFVTVGSKDKEQYLIDNYGSFITGIYSSRNKNYVNEIKSKLNQLYGTTGKFNGVDLIINTLPNEFTHSNFLCLKERGKIIDLSITHLNNNEFLNFNNFKFNKSYHNIEFMHINKRVVSRLLKSISNALNENKVKLIPITTFQIENVKEAIEYINQRKHIGKIVLDHSCSNGSIGSDGLLNQLIESDNNEKNHTILKYDFKIDTKNIIGKNIIITGQSGIILEILKWLIKYSPPTESFENIIILSKSSLKWELELLINKTISRKDNNTKFHFKIVDVGDSIEMRKSINQILLENPNIDNIDSIFHYAFTQVTKEVEEIDIESLDISHNAKTMGAINLHEISIEKSWKLKQFVMASSIASLFGSFNQCTYVSANLVLDSLSRYRKSIGLPSTCTNWGTIKSSGFVSRNDSVSKMLDDQGFIPIPTNIILGSLDLQLQNSNKYSNLIVSKFNYDSIKKFASETSTFQRLDFILNSIKEKDNDNNGGENISISESIQMKFLNKISELLSIEQSKINTDIRLGEYGADSLTSVQLKNFIDKENKSNVITLQQLQNNTIGVNIQIILEQIKKLDSNETKGKSKKIIKKDSAPSLEYWRNEMKLDESIQAIKMNPIDFRNDSKVFLTGATGFLGVHLLSNLIKSPNCSVVYCLIRNKKSEPNPINAIINNLKHHKLYHFHNEFELSKVKVIVGNLASPLLGLSKLDFGFVSNQINLIINSGADINLASNYEESKVVNIGGLIELIKLSTTGDYQKPIVGFSSISVFFESPNCKEFDEETVIPTIENINNLPGGYMKSKVVVENLFREAAKRGIPSMLIRLPIIFSHEETGIGHDSDFFQLIIQSCYAVKKYPNIDKNILTSPIGWIGLNTIKMIGNEKCWNKSSSNQLNIYSLNSEVSSIKSSFSFLEKQYGCEMVEYEQWKNIINQSKILSCIKFKTFHSLDRLNGVYNLGHGFGVSKKTKELLQSMNSYEGGMVNEKIIQNHINYIFKN", "length": 2778 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54TD0-1", "protein_name": "Peptidase S8 and S53 domain-containing protein", "gene_name": "V4-7", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MISKTSLLLLLLSIVALASAISVQRVPIADVTSAPAHFVQNKLAKSYELVQFKILLKQRNLDILEEKFWDVSSPKSENYGKFLSKEEIDSIVAPSPKDVKVVVNWLIDNGLSKNEMIVHSDFIQVRTNVGKASTLFETSFAHYSSSRTALKRIRVVGQASMPMHVLAKVDLVLGLSDFIEDNKMSESMRATKKQVQGSTVSITPAVIKQYYGIPTGQIGVESENFQSIAAFSDFYSSGALQFFDQKFGIDSSTVRVKNVGQNCIAQNCDQMESDLDVQYMTAIGNNITTLFLSSGNGEWIIDWATAIQQYNPIPKIASISYGWAEVEQCEITNSCSTLGIDSVVYVARSNVELQKVGLRGVSVFVSSGDDGAPSFGAASGNCPIDGTKQYCPLGGCNHKSSQCPMITIMESNGTQCFFPMGSESNTCQSMLQNQNIVNGINEFVSSNSKCQVALEQDTQQNYHIYSSCTCDKLKPYSDSDAGFKIVGYSYDQDAGTLFQPDYPASSPFITSVGATQITDVTKPEIVCSVATGAIITGGGGVAITQAQPSYQADAVATYIKSGTLPPSYSYNATNRFYPDLTLVGHAYEIAVPNTLTSNTCPCALESVDGTSCSSPTLAGMISLINDKLIGAGKPTLGFLNPLLYQAAKEQPNVFNDITTGANNCNRAYCCQYGYTATTGYDAASGLGSINFKNFEQYVLSLN", "length": 702 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54TX3-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFNFERIDHGSGKGTGIAIENRDTRKGHISINFKDDDGRILSIKYNSFNSINILLIYAPATISERNTFIINSKSLFKKYNSINHQIIAGDFNNNHDCNSFFGTELRKIIDQDMLLDTGIEENTPTFPRSMKRLDRIYCHPTLLNQNSKLVVHNTVFNKSDHFPITITIQTNRETTTTTTTKLERLPWTLCKEILNNKHIHDGLSELISKNKDKIKSVEEWTKFKNNVIRDYFKKEQNKIKKEKNKRKYVIHKLLGNSDIIPKMRKELNEEISRILEEERKVKAWDIKLKLHLHQETPSKYLTSILKSRAKDKSIFQIKDKDNKTISDKENIAKRFVEFYQDQYEEKEDNEETHKKLLEKWEVDVDLIKKLEIDRPIRIHEVTKAIKTSSIHKSPGLDGINALFYKYHINSIARILTIAFNDLLTNKKEIPTKFKEGVITTIFKKGDELNISNRRPITLLNTDYKILSKILNSRLLDITSKIINKFQNGFVPNRFIQDNIQIMKEVIEISNKRKNNTLITFYDFNKAFDSISHKSITRTLEHIGIPPKFTAILLNLLKDTKNKIKINDFLVNGITIRTGTKQGDPISPTIFALVLEPLLIDIINDNTIKGFTLPNSKSLKLTAFADDIATFTNSTEELMKINTKIQKYCSATSSSLNKEKTVMIAIGDKPHDLPFQESTVPERYLGLNFTKTGLNSKYNTLIQEMKNNLIKWKSQAITMKAKMTILKTYVLSKLTYHQYMDNLNEEQIEEINNMTRWFLFSSVKNTYTEERKYKTMMKIDRAYADWKEGGIKLWDIELRHIAFKIWYMNRLLHNNYNNNNNTLQEWYMEQLSRKKAHTSTLNDMCRHWGVFRVKFYQNHPKINELPDCIRNDNDEPLKLKEIYELMIKDRHPTPRRTEWQKLWAVRYNTAIPKVFININSISHQKGRNTLFRFFSRSLPGINHERDTRCKICGHLFRDPYSHLFTLCQDILDIEKTIISTVNKLSFIKIHRWSMDTLDISKYNRTERIFPNLIGIIAHQLWKIICHKLFNTDESKPEPKFEQKVIETELLNLIETEKFITLKKIKHDEAILKNTNQDLHKYKFNKAWQTPAAPNPLPI", "length": 1097 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54U20-1", "protein_name": "Peptidase S54 rhomboid domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIYGDTREFRNIHFHLNNIRIVGAIFGQDGFIHKKIPLATKVISIICSILFALSLVAPSMFGSYKTCLSIESLTNSFLDNLYRIILSNFAHLSIYHIVYNMITFLDLAKLERLTFGTLKYFYLLFLFGIITNLICLFIYFIGRNNVCHLGFSGVLFALIYIESNSSGRDVFLFNAVKIPSKLYPWAMLILAHVFVPRSSFIGHFSGIVVGILFIKGYLDIFILSNQKLSEIESSQLMNIFTTKNSYFPIIKFGGSRRSYNTDRKSLDGLFFELKNLFNPQQQQQRQQQRQQQQPQSPQPQQPQQPQQQPQQQPQQQPQQHQRDNFRNDNNDNSNNYDEYDFSK", "length": 343 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54VC1-1", "protein_name": "ABC transporter C family member 15", "gene_name": "abcC15", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIKKIKNIINKIINFFSTIYILCKIYLYYNIKNRYEAYNILSVYGDDDFFNKPCPEDSSNWKDKLTFKWVERIIFVGFFRAPLNLNDISDLPSSLKVENTAPLLKDIIFNDSTIPLIKHIYSKFLPRNYIATGLFVFVSVFSFITPLILKNFLSYVEKIDEQKHIYIGIIQCFLLFLSSFINMASQQYSYWFGFKTSLEVKGALETIIFEKMTKLSNLSKKNYNIGSMLNLMSVDTDFFQYFFCHYYIEIFLFPIQILSLLGFLIYVIGIAGFVGFLVMLITIPLSSFLGTQISKNLSTSMGYADTRISLTGELINGIKFLKQYAWEKMFCERIEEQRKLQLKYLYIRIIYWVLVQIVTQASSGLVLVSTFTTYTLLGYEVSLEIAFTSITILQNLRRPIESLPDCLHKFISLIASAKRIETFLQSSELQNQPFIHNQSGLNDILIRNINFNWNEHNLKLKNNKNNQNNNQNKRSIILSSGEQFEITNDFTFDGIDIQDDNYDYEKEYKINYNNNEEEENFMTDCLLKIKPLIKDRRLQQQQADYQDLLSINLPPPPSENVDFKAPKGLLTIISGGVRSGKTSLASGLLGEICKAVDKSSPDSVNSILSTIQQPFLQSTSFRENILFGKPMNMERYIKVIEACCLAPDLLAMGEGKDLTEIGERGINLSNGLKHRIQLARALYADSDCYILDEILSSVDPEIANYIFQHCIKGMMKGKTVILVTHQIQFISSADHVVVVDNGVLIQGTYLELLRMGIDFEMILKEKENRIEKQIVQLQEDEDYYEEVEILDFTMNNNNNNNNNNNNNNSNFNGNNKLKRSSISLPKGISIESIISKDFDQTTIEKAKLFVQEDRNKGDPGWIIYKKYIRMGSSISFFIFTCIIYLTSQIILLLSDYWLQSWASHDRLNVSEPTDVHYLLIYLAYIGGFVFTLGVRYLLIAKITFGSAETLHRSLLKSIIRAPLTFFEQNPVGRILNRFGKDISDIDILLLDCFSDVLYCGACLVTSIGIIIYISPYIAIPFVILIAINYIFQLFYNYSVLELKRIQSISRSPVYSLLSEVYNGLTTIRSFGQQERFFNMMKDNININLRVFFYNFAVSRWIGIRVEFLSAIVVLMSALFSIFNDNPGLSALGVTTALGITFNLNWFMRQFGELESRINSVERVQSYISIPKEKETNEDEFIQTGFIWPSRGEIEFKNVEIRYRPNSIATLRNFSMKINAQERIGIIGRSGSGKSTIGMSLFRMIECSSGSILIDGDDISQIDLKRLRSSIGIVPQDPFIFSGSIRLNLDPFDQFTDNEIWEALSKVKLKKMVSTMPMKLESLVQGGDGLTIGNKQLLCLCRAILRNSKIVLFDEATNSIDFQTTRLIKQTIEENFKDCTILTIAHNIDTILDSDKIAIIDEGELIEFDTPLNLIKDSTSRFSKLIKLNNNQKNKLN", "length": 1436 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54VG9-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKSIIILSFILSIISFSNGTIVKCTSASCSSLNNNCVNHYCNPRAGCYGIDKCVRIDACHIVSCDLNNGSCINTKANCDDGDPCTDDFCHNGYGCFSLPNNKHPSVICQKNCNDNNPCTDDFCDFTNTCQHTLKNCEDNDFCTIDSCGPNGCVHTNISCDDNDPCTSDFCSIMYGCYHEQIECSIKVPCSTDIECNRYNLCETYTCDLISNICKYSTKFCNGFPCINNECMTGVIYN", "length": 237 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54WA9-1", "protein_name": "Short-chain dehydrogenase/reductase family protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEIKKNIFFITGCSGIGFGGLMVKKLLSRGDYVAATSRNKNKLIQDIGSNENDQFLPIEMNLADESNVKEAIEKCIEKFGRIDILISNAAMGILAPLEETTDKDARTLFDINFFGPLNLIRNSLPYLRNNQFLKNNNDNNNSKLNGPRIIIIDSICGYSSLFNGCSIYCSSKFALHAISETMSIELKPFNIHCCNIAPGYFQTSFLSSCLIPDTRIAEYKDTHSFLDEIVKLNGSRFLGDLSKAVDVIIEISLSYSPPNHVLVGSDAFELFDLKYKKLTNDILINKEICSNTDKN", "length": 295 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54WC3-1", "protein_name": "Cln5-like protein 2", "gene_name": "cln5lb", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNKLIFIIICLGIVDKTISSDFKSYNDGIYSFTYDNICSFKNSIRDQDVYELYYVQAPLLYATYGNLLEKINAYHSGIVLYNKNNGPNITIDYYAIPSFEATLFPKSIIKDSQGNYNITWDTHGLIEVTNYINETYWNKRQLIMYDLSGIQIKQYLSWAPIYNKTHTFYNLFNIESDLSISNSSKIYKNSSTCDDFVWASFDVLYKLGGTIASVQSDPQRDDIKLFISSGEPKIVDYNDSIKRNQIASFFNELKDFANLGKNKTALEIFNELITFFNGYFYCYIDGEYYEMKLSKQNPISFTYLPSPIPIGKRNFNEIKKLGFCK", "length": 325 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54WW7-1", "protein_name": "Probable serine/threonine-protein kinase DDB_G0279405", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGCIFTKPSPEQQKFDGEDYECENKKNLNLISYIRNLLFGNNSHQQLYNEIIPTTTSTTSTTTNSVYQNIGLDGYNNNNNNNNNNNNNNNIMNNYGYDDYGYSYEEDEDYYDEMPIPTIVAQPQPQPQPQPQPQPQPQQPIRIVSQNQQIPTTPPQQISQFNITGNKSPSSIGSRHRSKPKETLRAHKKRHKDGHKMVNEYVFVRKLGKGTFGKVKLAYHHDTHHLYAIKIFNKIRLKKQTMGIGRPNAFDDVLKEIAIMKKMNHINVVKLYEVINDPQEEYIYIVMEYIEGGSIMSANETSEDLARKYFRDIVFGLEYLHEQKVIHKDLKPENLLVNSEGVVKITDFGVSHIFDDDDVVRCSRGSPAFLAPELCRNESQPISGKGVDVWALGVSLYCLIFARTPFISKTNSLLDIYDQIVNHEPTYPREISNDLMDLFKRLLDKNPLTRIQIAEIKSHKWTTISGTWPMNELDHLILSVTDQEMIDAISTDHTIKPSDNTTTDEDDSDLSSSSGGESSGIIGSSNESKSMYNNVNSKQKIQNQNQNQNQNQNQNQNQNQNQNHNQNQNQNQNQNNNNNSLIEKSNISIPASSSSISNNDSCYENRNVYIKDEEMNMICNDSVIMDPIKELNKIDGLNYGCDFQIGKEYSDFQYNSGHFIYDLVDENESQISRESANDYYLPFKTNKYLNNKSIV", "length": 695 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54WX7-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MARTDNVQLPLENTSIEFEEEIIDSQNDISQQKNYQDFLKNIPTDLNERKEYISSLKKLIKLEKRNHQQIQGEQPNQQEGLNSDRPPPNHHGDHHHSLPPPNHHGDHHHHSQPPPNHHGDHHHHSPPPPHHHGGHHHCPPPHHGGHHHCPPPPPHHHGGHHHHCPPPPHHHGGHHHHCPPPPPPHHHSHHHHCPPPPPPHHHGGHHHHTPPHPPPHHHGGHHHHCPPSPHHHGGHHHHSPPPPPPHHHGGHHHHCPPPPHDGNEYLPQSQTNIEQCICRLNRKKELLIAKIQSIDSIIYNLECLNKQNYQNNYLPSIQLQPTQQPQQPQQTSIKPQQMCQQFFIPQTPNFPQMNNSAPLMYVSQIPVQQSFNNN", "length": 374 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54Y59-1", "protein_name": "Small GTPase", "gene_name": "rsmH", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFNIFLSKSKDVYRVTSHKKEVKICVLGDANVGKTNFINQFTKSSFNEEYTPTIESRQNKLYKFNRKQFQIQIYDTAGSKELNLFVSDSISQCEGFIIVFSLNDRNSILKIQHYKTLIKNIFKDVEMPIVLVGTKMDLKKEITISKNECKITSVNNNIPNLFYTSAKNKESIIPVFKKLVDLIISKEKKVKKETESNNIKINNQNKIKKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHVFKTRSNSTLRMKKYLKLF", "length": 272 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54YJ4-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKKVYQDEEFSFFEIGGKKIADLYVRDIITEIRKRGKEITGLGLKSKYELLCILVNRMKEENPSLNIPPKKRVLDFGSLSSTTSNGILQDSNKFFKKDNTHQHQQQQQQQQQQQQQQQQQQQQQQQQHSNNSDDDDDTHNYNDDSDESDDEYIITEEEEIELHKNLNLGDDENLLTLEIKLLESQLENKKFRKSLLLKDKKIKHLENIIQQQQQQLLEQQHQQQQQQQQQQQQQQQQQQRQEEEQQKEQQQKEEQEQEQSSLKNNLKFKDGANLFSIESISNLYNKILNEFNFKKIITEFGDSSLKIHEEFVKFIILKSINLNHNNNKNNNKNNNNNNNNNNNNNNNNNNNNNNNNNNNSSNNLPNGDVNKNNNNNGEIIELVPPPKIDEFWKLMVLDTVGYQQFSNILGAKVNYDTDINPTRKGYQRLKDMKNLYFPPPPSTTELTTDEIWPNHYLLPIQPSPQKQHIQKQQLPSSSSSSSSSSSSSSSSQQHQQHQPQHKQQHQLQQIQEQQPQQQQHQQQQHQQPLQQQIQQQQQQQQQHQPQQQHQPQQQQQQQQPQQQQQQQQQQQQQQQQQQQQQQQQKKQQQQHQQQKNKENNKENNKENNKQNNKENNKLNDNNLNIEVHEDEGNRIINFLISPDTPLRNLFVAYAKEIGENFNSFKFYFGNELLCQNETPSQLLMRNGTKIQAFYLNKKEIKK", "length": 702 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54YV1-1", "protein_name": "Rho GTPase-activating protein gacII", "gene_name": "gacII", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MVRKLFNTSHKKELILDVDTTIVKIGTPKNVVLLTKWLDANGAIKEEGVFRVNGNTTTMEQIKKNFSQGKDDLTKYTSADIHSMAGCLKFILRELPEPIFTWDFYPIFIKIQCLQDESRKLFFLKMLIHGLPYTSRTLVFQLFGFLSKFSVHQDQNKMTPKNLATVFAPNVLRPKKEEDNFQLMNNQDSIGVIETLIEEFQYISNIQKNTLNSQEIKVKSVLPFDETTNAITQQSLVEDYLIAKANTPQESSSFKKNLPFKKGDIIKLLYIKNDGNFIGEINGITGNLSQTYVDIIDISELAEAFTLTPPPIPTLPIASTILHTPPTSSSSSSSSSSSSILLTDNQPKLCSSTPRINNSPSSFSPSLSSTTPQLLVQQSPRQSPRQIPSISLIVEPNNTNQPSFGHGTLQRTSTGYFSSKPLSISQPINMSKPTNMSPPTHHAMSMHNLPPSNTTRENHLPPLPTKPPPLTIPSSSSLPTTPIKQQPQQPIQQPLTPQNHHHHHHHNNLSSSVNTANTGNCANILSPNSDRYLSSRSQSSVHLSGSSSSSSSSSSSSSSSSSSSSSTSNRKFDFSLKSKSSKNSPSKNLPPQPTTTSTLTPPPPPTITTTTTTTTTTTTTTIATTPPPPSKPLPNIPVKDQQFNTLKRSTIEIPPPTITSTNINNNNNTINPRTLNYSFSSFSITYNNSQLGGQLSQEEPPGGVKSQSSYLDNNNLPSRNTNIPNLPPRPPPLNIPQQQQQYKPLPSPPQLQSPQSSLNQSLQIPLQQQQQVQQQKLTTHYILPPQNTNLSGKNLQRSSTSMLLNKLPPPPFSFNKN", "length": 817 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54ZA1-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIKIMTWNCQGCSTIKSMNQTKNTINLIKPDISILTETNLKKDQNLAQIKNHYSTGGKGKEARGKGVMAINHLEQIEIKNLEEKEGRILKFTAILNNMEINIICIYAPASYDRRKGWFSNNISLEDLEQADIVTGDFNINKYAKIKFKDGSSDKRKFTENETIEFLMMEVGLTEILPNSTTKTTFKDKLIDRTFLSTKMHQLNHSYKIIDKINKSDHNIVVMDFKIPNFTKIYKSPLWKMNSIIIKEDKTIKKIEKIIDHYQETKRKNLNITEYWIKFKKKIKKQCITTEKKRILERKKTLSNLANEHTKTKNKYEKETISNEITILQEEERIDRMIKSSINYINNKEIASNLLTSILKKRDSGSQIHRIKNPSNGEIETEQKEITDCFRKYYETLFKEKECDQETHTELLSTWNPPIDKKKLTEMEDRIEEYEVKLAIEKIAEGKSPGEDGITSSFYKIHQHKLIPILTELFNFFLNNEIPTEFKNGILTSIYKGKGDVLEISNRRPITLLNVDYKIYSKIINNRILKILPNIISKYQNGFIPGRLLHNNIIALDLAMEKSDRNTIITFYDFEKAFDSISHKALIRTLNHLKFPRKITNTILSMLTNTNIRVMVNGQLSESFRAGRGTKQGDPISPTLFAIVCECLSTSIRKDNTIIGIKLNQNNSMKIGQYADDTVTLASNIDDADKMDMKVIKFCQATAAKINDNKCVCITKNPKIKTKYKTIGAKEEERYLGFFFNRKGVISKVDDTVNKLENLTKCYSSVSSTLKGRITILKSYLLSQLTFQLYINEINDIKKLENVNANMLFKGDRWAISKERSRRDYEIGGLELWNMATRSNAQKAWIYEQYLREKDDQNCPPHMEVWKSEKENSLSRIHIKCWKAWKLLHHPRERITLKLNQVKPKYENKQKLKVIYRNMMDIKYKGWNKHQPTTGQKLIQKNINHPILPFREARSITTIKGRDLAWRYLLKALPKHHGENCHSCKEEESSMHIFFECKSIKQNIDSIYQKVCKDSNNTYHGPWSEKVLGKLLTPFSSNLIGAIMESIWYRRNQIKFNDNTTIITENQIIHKIKKARDAEWDRTRKIVEKQLRQELRCTDNRESINRTASIKRRLEKFSHNWNSKLMTINIPEHFIPYCSYNTNYS", "length": 1144 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54ZA6-1", "protein_name": "Alpha/beta hydrolase fold-1 domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEKINQTPKKHKIIEPNRKGYSIVGKNTGKPNKIYFETFGNGPKKILFITGFLSSSKGWCKQIDYFTNKKDQYEICVFDNRGIGKSNIDSKYSYNFSTKSMAMDAIDLLEDTLKWDKVHICGLSMGGMASIHLSSIIPEKVQSLVIACVPNGYFLPFFSMGVFNYIRAFFFTFNEKKKARIFQSLMYSDNYLDEKTNGSDETRSEQMFKKNSTGFKDDGPSFLTILGHQIGYITNRFSKKSLEVIKKYSIPTIVINSKKDSLVTIDITKKQIVNPLKPLNFHVIEGGHLSQLENPTFFNKLVENHVDKHSNWDHSTFFQVEKQQFQRQSFMTQNILYSKNYLSSNTLSSSFLNCNTLRSFFNKIKV", "length": 366 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q54ZT3-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIAKTQIKCTTIYAPAKSNERHEWYKENLTEEILHSDIITGDFNVDCSVDNNLNKYIKTIFDEFEFTEIKNGITFPRNKSTIDRVFVSKKILHLNPIVTTKEIKLKSDHNMVIIELKIPEYEQQKKGERLWRQNLETLKMNSTSLKINKTIKYYNKKFEENTSKWYKLNICEQWLKLKDEIKKLSINIEIRESNKTKNKLKELAEKLETAKDSRAIFLKEEINNILKEQVRIKQANQTNTHINNKETPSKYLTRRLKVQRKTNEIPQILDPSNNCLVTKNEDILEVARRYYENLYQKRECNEDTHHELLKTFNKRIDQKILDEINQPIEGYEIRLGIEKIQEGKAPGKDGLLPTFYKNHINEILPIISKLYNHFWNTTIPKDFKQGILITIYKNKGDPNNLDNYRPITLLNVDYKIYSKIINNRILKFLNKIISPFQTGFVPRRLLHDNIITLNSTIEIIKREINTKEDMEPIITFYDFEKAFDSISHNAILRTLAHLKLPLKMVLTIMNLLNESETSVYINNSLSKSFTSKRGTKQGDPISPTIFALVVECMATTIINDRCINGVTKETIKILQFADDTATIAYNFMDHFLMNEWIKKFCQATSAKINQTKCSCITFKWNTRTLYTVIKSNERYLGFDFNNKGIKSKINTISDNIRAKLVTWNSTSSTYMGRLIMAKTYALSQLTFHTYINTTPQHNSIENNIVKFVFNTKSKNSLSLQRRQNNYINGGLNLWNLKTRELAQKAWLFERYLHQRVSNTPSSYIKLWEEELKNNNNNKTTTKQNQLQLHWQCKQAWTQLKTPQNKQTHYEHLPKLKKIYEDMMTTQSPEHNKFIPTPGQKEIMTKINSKHLPFKEIKKIINMKGRDLLWRYTLKALPKIYNMPCQQCGEDETSEHIFFNCKAHIKNTQEIFNYTLTKSGHTTHTWNVKILNHLQIALVANLIAIIFDKIWHKRNKLIHDEKEIIIHRQQVIRELIKTQRAAWDRTQAVINKTLRIKSKQRPEEQNKLDSLISLKLLQFSRQWNSPLHAIELPKHLKKYNNSLSTFYK", "length": 1047 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q551H6-1", "protein_name": "t-SNARE coiled-coil homology domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MATRDITSSYILSRTECKNRAKIINSAININIKKSGSGYKRLEEENYQDIDIDNNNNNNNINNNNINNNDNDNDTTNNIKNSNNNNDIQLNILDTEINIEQLNSLPPWILKLNDIDENIKKIISLIEKFKKYLKEDIDKILAEDIEMESRIDCERSIELLTMETIRLFHKTFDMIKYLNKSNNSSQGENKMKKNTQRMKSAKLKALLITFKHIQRSYLALLKKVSSLQRSLSSSFLYRSGEYDVNNDNEDYGENSSISNSHYLQHHHNNNHHHEDDHDHEEDHEEIMDELNEMATTLIERQRVSQLIKETSHLIQDVGSMCVKKDSIFDRIDYNLAEGEELEFNGTILICDGITNGYERPENEKRKKLLLIFAVLIIVILFIFILKYVIEI", "length": 391 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q551V5-1", "protein_name": "EGF-like domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKYLFRFFIFLFCITRINSQTGCFFRETGADYNIDSVFSVFYVDNLFNIFGMTFYMKTCTYVTCDPWRQTMICGNYNSTTFQLGPYQSQKVTLNKNGISIEYLSDKTPPNHPCPTITTTVKFICDKSVLSVPKSDYDYVGTCGVQIKLFAIDYCQTCSKCIASHGSCNSTSGWCTCDSYTMGLNCDQLKASISSVVAPTIDGGSVIISGDFSSIYSLGPSLVITIGSLVCSQVSFAASTTQISCTIGAGQGYQNLTISDGSGSTLQYKQFYYHYPCQEDCTPYGTCNDVIGKCTCNYKYSIGADCKTLNLQLTSVKPTLLDGGQAYLVGDFSNVTGLTLSVKIGIKECTDVNFNETTLQCTIGSGEGIKDIIITSDLLTYSKIGAYEYQYYTCPLGCLHGTCNKYNGLCVCNNGTYGDQCQYIECPLDCSTPNGVCDKDTGICDCDDKYSGEGCDFIKCPLDCSTPNGVCDGKTGICNCDEKHSGDSCQFLQCPLNCSNPNGICNRNTGICSCDSKYSGEGCDFIKCPTDCSTPNGTCDGKTGTCKCNNPYTGENCDEIAKCKQECSLKHGTCDSHTLDCICDTQTKGLSCEESRLLIESADPTSLDGGTTTITGYFGTTTSLLSIKIGDSQCTNIKVESDTKLKCDIGPGEGTHNVTVTDDDLSFTGVGMFQYVGQINKISKISGGAIAGIAAGCVVGVSVLGAGGYYQYRKNKKIELFMS", "length": 722 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q554Y8-1", "protein_name": "ADP-ribosylation factor-related", "gene_name": "arrB", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGMGFSFIEKKDFKRFLILGIDNSGKKKIMYRLKFNKDIPTRPEKGFFVETFERRFKYNNEDVCGQNMIRPLWPNYYTDETNGLIFVVDSSDQERIEEVRLEIKKLDENIKIFKNHPFLIFANKQDLKNSLSIEQLIDKLELNKLSLNRKWHIQSSNAITGDGLEFGLNWLFSSSHNFT", "length": 179 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q555E8-1", "protein_name": "Putative fatty acid elongase DDB_G0274669", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "METVQSIITEWTDPKSWEKLVQHSFKDSNWKELIDPVNYKFNFGVTPFSQFQIIPIVLVIYLVTIFSIKFLMKNRKPFSLKFISILHNAILCIWSLIMCVGVLYEIIKRVSNEGPLFTVCEDPNGGFDKGVTYYWSYIFYISKFYELLDTVIIVLKKKPLIFLHVYHHCKTVWWKKYITMIQILQFVCLGIAGVLHVYTINTIGCFTHYPAFAAAYSINFSFLFLFSKFFVKSYTPKNSNSNTNIKSKKID", "length": 251 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q555Q5-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MRSIRIKKINFHIKQGEEQLKQELNNYCEETSLKYISARIKKRHNDFTINAVKDAQGRTINKQELIEEEYVKYYSNLYDYKEDDAPSHYEMLENWTVTRDSTWDNLENEFTTQEILEVIKQLNPHKSPGPDGIPNLFYITHKEKLAPILASAFNDTLRNPHLISKNYKEGLIITIPKKGDPELIKNRRPITLANCIYKIHSKLINNRIIPILTKVINHNQKGFVPGRFIIDNIISMNELINYCNDKRINGIITLYDFEKAFDSISHGSILRSLQHINIPTNIINLIMNLLTKSEARIEINGRTTIPFEIKRGVKQGDPLSPTLFVLVIEALARKILQDDRITGLPLNNSDHREKFQSFADDSASMVPDSQQLELVLQHFNSFCKATSSKLNIDKSSSILIGNPDNTNQRIPISTNPERYLGYFFTGKGITRKIPEILNTIRSSLVLWKTTDSTIKTKTNILKAFALSKLTYYSYVENFKEEELNQINKLVEWFLSAPNTKMLVDFKITPKLSPTAKKDQEVNADYANHRFHKEYFEWNYKAIDYDLTRSFAYRNLMALILHNIWIWICNQIYSEDPLTDESLSYSSLLKKWHKLATLEYIKKAKDLKNLSAKDHNNFKDPKILLTSTIKLRKTTANYYCIPESSLPNIISFDQFI", "length": 655 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q556H5-1", "protein_name": "Cofilin-3", "gene_name": "cofD-2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTTPKPTIAKISPECQTHFQDIKFRNKYQGILLKVNEESNMVVDKTLVAEGEFSELAQSLPTDQCRIIIYRYKSGEGSKLFFIYWGPDSAPQQDKLIYGNAKVTLAITLKGIDHKISASNLKEISEQVFIDRITPKTA", "length": 138 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q556J5-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MWNHNLCHAINLDRQFDHINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNNNNNSYDYSFSVHSSQQYSRHYPNSCNNEQTKPKDYYDHASRSQHDYHANGSNNGNNNNNNNNNNNNNNNNNNNSNNNNNNNNNNNNNNCDSNYNSNNNNSNNISIANIKYQQDQHYQHSDTYTSHQYNSFNDNNNNNNNNNNNNNNNNNINNDNDNNGYNQYDESEEDEEEQDDYDEFDIQDSASSYNDNCGVLNSNTYIYDYQSPQQPLYSNEYQNNNHQPQQTDSYNYNNTNNDNNSYNINNNNNNNSYNNNNNYNNSNNNNNIGNIDSNTNNNNYNYNYSNNGDVYNGYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNMNNMNNMNNNIITSNREQFYSNNNHNNINQYQYQSQQQQTQQQQQQTQQQQQQTQQQQQTQQQQTQQQQQYLTQYYQQELYSQSYKCRPYYQNSFVISKC", "length": 480 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q556P1-1", "protein_name": "CWH43-like N-terminal domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MISSSLKPSVLLWILAILIPSTLITTYTLTVLLFHGIRRTVPYISDTIDFSPESCIGTFFISISAFLVFIVVFVKHFLLQNNINQNFNIDIILNENENEKKKNRAKMLNRISTFLGLICGVCIHGVSSFQYHNTGLVHSIFAASFFFTGFIYIFTQTYLDHKFSKLPKRILILRRVISLTTSVFIGYIILQFFIDNLAPILKIISALSIFFYLISFFYEFSKITINFQINTISQIEHQKEYNENSALLISQ", "length": 251 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q556R5-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFNFERIDHGSGKGTGIAIENRDTRKGHISINFKDDDGRILSIKYNSFNSINILLINAPATISERNTFIINSKSLFKKYNSINHQIIAGDFNNNHDCNSFFGTELRKIIDQDMLLDTGIEENTPTFPRSMKRLDRIYCHPTLLNQNSKLVVHNTVFNKSDHFPITITIQTNRETTTTTTTTKLERLPWTLCKEILNNKHIHDGLSELISKNKDKIKSVEEWTKFKNNVIRDYLKKEQNKIKKEKNKRKYVIHKLLGNSDIIPKMRKELNEEISRILEEERKVKAWDIKLKLHLHQETPSKYLTSILKSRAKDKSIFQIKDKDNKTISDKENIAKRFVEFYQDQYEEKEDNEETHKKLLEKWEVDVDLIKKLEIDRPIRIHEVTKAIKTSSIHKSPGLDGINALFYKYHINSIARILTIAFNDLLTNKKEIPTKFKEGVITTIFKKGDELNISNRRPITLLNTDYKILSKILNSRLLDITSKIINKFQNGFVPNRFIQDNIQIMKEVIEISNKRKNNTLITFYDFNKAFDSISHKSITRTLEHIGIPPKFTAILLNLLKDTKNKIKINDFLVNGITIRTGTKQGDPISPTIFALVLEPLLIDIINDNTIKGFTLPNSKSLKLTAFADDIATFTNSTEELMKINTKIQKYCSATSSSLNKEKTVMIAIGDKPHDLPFQESTVPERYLGLNFTKTGLNSKYNTLIQEMKNNLIKWKSQAITMKAKMTILKTYVLSKLTYHQYMDNLNEEQIEEINNMTRWFLFSSVKNTYTEERKYKTMMKIDRAYADWKEGGIKLWDIELRHIAFKIWYMNRLLHNNYNNNNNTLQEWYMEQLSRKKPTLQPSTICADTGVYSESNFTKTIQR", "length": 861 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q556X2-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIAKTQIKCTTIYAPAKSNERHEWYKENLTEEILHSDIITGDFNVDCSVDNNLNKYIKTIFDEFEFTEIKNGITFPRNKSTIDRVFVSKKILHLNPIVTTKEIKLKSDHNMVIIELKIPEYEQQKKGERLWRQNLETLKMNSTSLKINKTIKYYNKKFEENTSKWYKLNICEQWLKLKDEIKKLSINIEIRESNKTKNKLKELAEKLETAKDSRAIFLKEEINNILKEQVRIKQANQTNTHINNKETPSKYLTRRLKVQRKTNEIPQILDPSNNCLVTKHEDILEVARRYYENLYQKRECNEDTHHELLKTFNKRIDQKILDEINQPIEGYEIRLGIEKIQEGKAPGKDGLLPTFYKNHINEILPIISKLYNHFWNTTIPKDFKQGILITIYKNKGDPNNLDNYRPITLLNVDYKIYSKIINNRILKFLNKIISPFQTGFVPRRLLHDNIITLNSTIEIIKREINTKEDMEPIITFYDFEKAFDSISHNAILRTLAHLKLPLKMVLTIMNLLNESETSVYINNSLSKSFTSKRGTKQGDPISPTIFALVVECMATTIINDRCINGVTKETIKILQFADDTATIAYNFMDHFLMNEWIKKFCQATSAKINQTKCSCITFKWNTRTLYTVIKSNERYLGFDFNNKGIKSKINTISDNIRAKLVTWNSTSSTYMGRLIMAKTYALSQLTFHTYINTTPQHNSIENNIVKFVFNTKSKNSLSLQRRQNNYINGGLNLWNLKTRELAQKAWLFERYLHQRVSNTPSSYIKLWEEELKNNNNNKTTTKQNQLQLHWQCKQAWTQLKTPQNKQTHYEHLPKLKKIYEDMMTTQSPEHNKFIPTPGQKEIMTKINSKHLPFKEIKKIINMKGRDLLWRYTLKALPKIYNMPCQQCGEDETSEHIFFNCKAHIKNTQEIFNYTLTKCGHTTHTWNVKILNHLQIALVANLIAIIFDKIWHKRNKLIHDEKEIIIHRQQVIRELIKTQRAAWDRTQAVINKTLRIKSKQRPEEQNKLDSLISLKLLQFSRQWNSPLHAIELPKHLKKYNNSLSTFYK", "length": 1047 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q557C9-1", "protein_name": "Homeobox protein 5", "gene_name": "hbx5-2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "METIVNNQNNGQQNTVPTQSFSSSVYMNYDFFDSQQLQQPQHQPQHYQQQDSFVSPNLDNNNPQIHVQSNNYNQNGFVGYNNSNNNNNNNQHMNNQYSNSFHNNNSSGFMAFQNNSSNFNNQNNNNSNNNNNNNNINSYDYNNSNNNNYNNNNNTHSNNSNNNNNNNNSNYWNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNNNNNNHHHHHHQQQSQPTSPYNNPIQHNPNDMKFNGQHNPFNGNQMVMDNNNNNNNNNNSNVFNSNSNSNVFNSNSGSFLQINNNNGSFSSYNNNNNNNNNNNSNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNQFSQSYDSTLGNNRFSSMMGQPIQQQQSPPQQQQQQSFIQSSPQAIPASNCNGNGSTSSSTSPLSPTLIGSAPGTPTSMLATTLFGFNLSSSPTSSPSSPVKKGKSQSALALSSSGGSGGSSGRKKPQKHDSMSSITNTNLKSTQASTLKESKRSNSSPNLKKQMQLQQLQQQQKLNENGTLIPPLPFASISENITNNNNNNNNNNNNNNNNNNNNNITNNPLSGSMEFPNSNNINQSSDSINGEFNIGQPESPKMYNSSPSPPPNATSTTKGGKKSKKSLHISTTQQSPSLNGSTGGSMLTPTMSGLSLSGGGSGGGFSPLISPTGTTSNKDLQSSPSPSPLLKSMSMGKLDLQDSIDSMSSPLSPNSSLSSSNGLLPPPPNSNNMNSSGGIPTPSTPTSPPPLTHHINIFSNLEFVKQLKDHLLPNDFKPEEHALERNLLRFQQFVKTLAEPLQRDVVTSMFELSVDAQLQYGSNLDNDNLSALMLFRRKILNFNLFRMMMLNDPNSFIPLPSPFPIQTTTISSNGTIVNPTNVNNNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNTTTTTTTTTSANTVQSGTTSNSNLVFQQTSNSNTLSPSQQQQQQTQQQQSINGSSTGSLSDAQYQDLGIHLDTSSANSGCGINVSIGSSIGGGGGGSSLNGSNLNGSSSISGSISGGSSNGGGQFIMSPQFSLDGAYQQQQPSSYNINNEMELAEKDEDEIFNNNNKDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSSSINSNINNVNNCNINNNSNSNNGSINSPRPSTPTTLNSSGKRSKKIYRGDSFGAGNDISTGLMASSDQIIPPPQQQQHQQLVNNNNNNMNNSENNILLADSNKGLSVSLGSLPTNTPSSMEIEQQQQQQQQQQQQQQQQHLNQQQILHQQLHHHLSSSLGGAQFTNIQQQQQQQSGNIFYNSPYNSSQVYMNPYGTSITNTSLAGPSTTSSAMQHMITNMTSSNIIVNNQNNNNNDQNNNNNNNNNNNSTTNSNVNNNNNTTNTPSSPPQPNNCTPTQTSIITSNGVVVPSLQMRGTITNPPPVLPTPDTLVLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQETPHTPTSNSISSPRSSPVHQQSPSNTNTTTTSTTTIRHSAVTQLSFAGLHNQQVSPISPRSPRSPHGTSGDYNDGSQSPSSRRKNRFTDFQIKRMNDCFENLDKNNNGKFTSEEICQIATELGLTDQQVRVFFQNKRARSRPSPRGQPTNPLTSSTNNGNNSNLALQHLQQQHLQQVQQQQQQLLQLQQQQQQQQQQLHQQSANTTPQLNSMNPNSINYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIINNNITTINE", "length": 1723 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q557D0-1", "protein_name": "RING-type domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTGSNNLNSLNNNNNNKISLQETIQDIIKCSICLNSPKNPRFCPRCSALFCLECIDRWIISNPTCPACRDTLTSDNLNSNLIVSNILNELVKSEQEEYTSSDICNYHGYERLYYCSTCQEPICSDCALFKHKDHKIEKLSINFNKNLEILKIEEEALKKRQEELIELNSFLELDAETLLKNKSQIEKEISKVVITMKARLKYDFERRYNTILESQEKINNELTHLDFIYNDLLNHYKKSPSSFVLTSQQFIGVLQSVHKNSIMDIYTPINTDLTSELIPPFENRLLKFENFTTGDCLFSSRIAFYGMTWEIKCGIEEDNCFLNLKVLECNSDGKYFYMFTIVNQKTNVNKLIEFDLPFQAGETFYIPNFSSKQTLIDEGFILPENDILLLQFSFRPQNYFCYSNDLKRYIDILEYRHRGYFGEEDEDDGTIETTVTKLPNDKSTILGSDNYNDNYNDDGIGDLDEDEEEEEDDEDDDDNLDDHLQYDNDDDEDEEEDDEEQNEEDNDEEGTNIPTSEYEDLDTSSASVISNINRRDRFKNNNINNNNQFVNSNNNNNKYNTTNSNNSIVGSSRYINNNNNNNNNNNNNNNNNNNNNNNNNNNNNYILNRSYSTNKIYNFYQDEEEEEEDDDSNIDDQDEDEEEEDSEEESSLSSSDLQDLDSSGDQSSLEFSFSKYTNNYYSNNNNNYNSGGGGGVGGAGDNNKIECIRRDFNNLLKRINFTNSQLTNLKPGVPKDGDLLNDDENDKKCNIPLNEDEEEDEDEEDDVNKNKTTSTTTTTTTATTTNEVVTINPNTISNNSQDEEEVKSDIVKLLENGIANMLNNSNSSNRSSNNLKQQQQQQQQLQKDDQKQKDEQQNKSNTGCDIDQLNILSKLSIKESCDSIKNNDNDSLGNSTNNNNNNNLNNNNNNNNNNNNNNNNNNNNNNSNNNNLQSFLQSNENTENETDFNDNNTNPETNTETENEYLTSSNMNLDGGESEFDSNKSYEGSSTDENFNSDEDYQDEDNFNQDATGSESANNDDYLDDNEREGSDSIENYDEDIEKVLTSHNIITTPSIPPSQQPQPQLQTQPQTQPQSQPQSQPQLQPQSQPQPQTQPQLQPQLQPQLQPQLQPQLQPQLQPQLQPQTQPQQQKKYDDLSENQIQTENRNKKIKEEINNKTNNDNNNELGKSSKSNTSSSSSSSSSSSSSYSESESSESDSNNEYDNEDEDDIVNQVSNFNFNFNDASNFKNFSFRPKFPSDENDNDDNDDDYEINIDLKNIQKISPILRAIENGESNINHYQSPVSLSSSSSVSSFSGSGNSVPITATTTTTTTTTTTTTTTTDDDSGINMPISPLSASPPSPPPQNEPQINNETNDNDVKLPQI", "length": 1364 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q559A9-1", "protein_name": "Probable polyketide synthase 13", "gene_name": "pks13", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MENFKYRNNENDVAIIGIGFRLPGCKNFTPNELWNNLKNGFNGVVELSNRWSDNFYTMGKVSSAYAGLLPFDELKSFDPLFFGINPTEVPTIDPQQRILLKCTWEAFEDAGIDPIKIRGSNTSVFIGTSTNDYQRIIREKDQTITNAFGTSLHATSNRISYCFDFRGPSMTLDTACSSSLNCVKLGYQSIRDGTSNLSIAGGVNLIIDPYFTASISDLNILSKTGSCKTFDASADGFARAEGSGIIVMKNLKQAMIDGDKIYCVIKGASSNVDGGGLQDKSNFYAPSSLSQCNNIKMALKSTNGTVEPKDISYFECHGTGTPTGDPIETRGISMVFNDESRSKENPLLIGSIKSNIGHLEAGSGIASLIKCCLMFKNKCFAPNINFKVPNPKIKFEEWNLKVVTEPIQFTKSNTCIGLSNFGVTGSNCCLILSQFNNNNNDNQIVGNNNNIKSNKEYLIPFSSNSVKSLENYQQLLIKNGENEFKFLEFIKHQIFTKPTSLYQRSVVIASSWDQFNNAKIMKTSNSKSSNISIERNNPITVFVFCGQGSQYDRMGLELYNNDFIFKESMDLLDNKLSKYYGYSVLEKLRNCDSKSIQHPMIAQPVMCMFNISLFELYKHWGIEVSFIIGHSLGEIPAAYCSGMINIDTLCYLIYHRSIAQTKTHTNGRMLSINISADEYFSQYSKQYPDIEIACFNSPTSIVIAGNEQKLNEISEILKEKGIFSAMLASLSSFHTSSQNKVKEDIVNKQFDSKQSEIPIFSTVTTNLFDSVTSPFNSSYVFNNIVSPVKFSQTISNLYKHIESNQLGNDIVFIELAPHPTLQFYLKQMIPKPTNDDNSIEFKVSVYSALNKKNNDIEEIQRTISQLYCDNGYNVNFKCQFQHDDTHGSINSNINQLSNISLPHYQWDDEKYWKEDPSISKLIVNGPQTDNLGYLNENSPNSKSYETFIDIKRPPFQYLKGHMVKGKYYFPGCGYIDNLLKIYKSQDLTINQMGFKSPLIFIEGVNQALQTNIFKKSTSNTTTNNNDEFRVEYHFNDQKTNRWILSSFGDFQLSNHSSNSDNLEKINIKQLIQNQCNLTKLSRDELYSHIKSKTGLTYNGVFQGVNKCYLGENCSLSEVSLELKREPSSFFNTAVLDTCLHGMLCLLEEQSQLVFDRIEGFKYHSSNVPTSEEEMKIHSNIYVYSTINPSRIGDSYSASIVIMMEDGTVLIEIENAVCTSLTPIKESISVKYPTNQLFSMYLQSKDSPIPSPLNFKSLYNQNQQQLKIDKQFTDWMQKCEKFISNQFFKNIEKRNPEINLEILNSKTIIELKSKYCQNLKNERLFQFVFETIKQLGVNAYDDDDDLTIDSSEDRKSIYEILIKSTKVIPKLLFPLEDEDLTIDSPQSLFENGLLDRFYNNPNLMTNQCQLIAQIIKESLKPLLNKKMVFRILEMGGGTCSLSVVVLNLINQLLLENPSFEIDIEYTWSDISPSFISAAKEKLSHIDKRINILYRSIDIEQPFIEKQDLSPSYYDFVIMSNVLHVVKKLSPSLDEIHKILTPNGHLLFVEIPYKELISDSIFGAFNQWWAFEDTDIRKDRCSIPPNQWIQVLSNHNYKDTIVSDNKECTWCCFVIHSQKPSLLELSKKIECNQYDNIIVFGNENSQDNFTKSIKLSYNNNIIKWVSNIVEIKKFIKLNIITNNSIIYFTKGIEELTIDNFKLINFQYIQINQLLLKYESKCKNVLVTRDCDGSNYLASSLIGAARYFDEYRQLELFTLDFDNDTIQSCDECSSSSCSNLIKLIEPLIDPKINIQREFLIRNNRVYFERAKLETNLKKSFKSESFENSNKLISTLNFNLDYQLQSKPFKQLLQNEIEVEIKATGINYRDYLVFTGSLPIEKTNHNGISNQPEFGVDFSGIVTKVGGGGGNGEFKVGDRVYGIGHNTTSSHITIDSRYASLIPNSLDYIEASSITSSYILSLYGIFDIGNLDIQDNESILIHSGTGGIGLSALNSLRWKGHKSHLFVTVSSKEKEQYLRDNYGSFITGIYSNKDKNYPKLIKEKLNQLGSNKQGVDLILSSLPNGDDNLNFKCLAKNGRIIDLSNNIDLFNISKSKIKKLLNTINDGFESGELQVIPIIEFSNSNIRDAIEFINERQHIGKIVISHDDSNLLIDLINKHSNQPNYSILKSDYQISQSNLGKNILITGQSGIVLEILKWIIKFSNSIENVIILSKSLMKWELELLIGKTMKKANNKIKFHFKSVDVSDSIQVENSINQILNDNPNIVNIDSIFHFAFTQITKKVEEIDMESLNVSHNAKTIGAINLHNQSINRNWRLNNFVMASSATSIIGSTDQCSYVCANTVLDSLSKYRKSIGLPSICTNYGAIESAGFVSKNESVAAMFNGIGIISISTDLILGTLDLQIQNQQSSTNLMLSDFNFLNFVNNNLQLSLISKFDFQTNLAKNQVNEKLQNQTQNQNLQIQSPSSTTDCQTIIKDSFLHKISEVLSIDISKLNLDLKLLDYGADSLAIVQIKNWIDMEVSPNLIVIQQLQTFTITSSIQYTINSFLKKKVQSQE", "length": 2551 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q559I8-1", "protein_name": "Uncharacterized protein DDB_G0272530", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKIKLILVLIVFLTIVNVNNSIDLCLSNPKKALVNQACKYSTDCEYPLFCGSGNGYGKNATCSKNIETGGSCESNNQCTPCNVCFNAKCKVKLYLGDACDENKSYCSSSVCIKGKCSIQGDVCTANNQCKFNNYCKSGKCVPLEKEGSSCDKDSSCSLTNACVGGKCVTKYQKPLGAVCNSSNECQVFSGHVCGANGKCSVYNQLLSKCKENSDCGPNGMCMCKSETENVCVDLSVGALKNDKCPSLLSSFSSCMTRERCTENTPTGCPKCYPIFMCYQYSCFYMNQFIRSTQNYYKSFCS", "length": 301 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q559Z2-1", "protein_name": "E2F/DP family winged-helix DNA-binding domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNISLLLNNRNRNRNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNGNANESASLNNGSEEIRSNPSSNFSSPIQSSLSSSSSSLSSNQATTPKKRSHAHKNSLKCQSPQMSPQMSPQMSPQMSPPLQYFPQHQMQHLSQYQLDHLQQQQQLIQQEQQEKQQQQQQHQHQQQQQEQQKQQQKQQQRLSPQPRSSQPRSSPPRSSPQRSPQLNQQEGHINSVQTYSGNNINDKNQNNTNNNNNNMSNNNNFHDDNNCNVNYNNIRNNSNNNNNNNTNNNNNNNNNNNNNNNNNNNNINNNNNNNNNSNNNNWNNNYCNNSFADETNKNNTYGMEYINISEENQYNNNNNNNNSNNNNNYNNYNNYNNNNNNNNNNNNSNNSNSNNNNNNNNNNNNNNNNNRNNIINSNINNSNNNNYNDNGYNNNSNINSNDSYNNNNNNNNNFNNNNFNNNNNNNNNNNNNNNNNNNNNKNNNNSNSYNNNNNNYNNNNNNFHNNNNNSAHNNNNNNYNNNNNNNYYNSNNNNNFHNNNNNNNNNGNNFNNNNNNNGNNGNMFTNVNSIDNVNRNNYNNYNGNNNYNGNNSNNNNNSNNEVSQITTTSLPVKKTKVFKAPREKKFKRGPDQDIREIKPATALLKQYFIGNSITEFNAERVGSILKINHEKLKDILDIMECASLVINNHSNNYVWLGLDNPGFLKLVFNVFHCSSNLVTKEPEFACLKCKENAYRCPTSVDLPKDTRLGSTVCQFMKLLLSKRIRTNPVNDFLTIYQVCFNFNFCSEGRCPEEDFKYLRNTAKVKRCYDVANVFNGLNILEKVGKSKIHSYQWCGDFTIQDCENGCPFGHPLLTPGTAYTTNPSPNPFNQFSNAYISSSAQSSLSNSPFIQGGFHGNNNNSNNNNINGNNINGNNNYGYNNNNNYNNYNSNNSNGFNNGNSFFQQQQPLVNSGVSMVRNNNYSYSP", "length": 964 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55A39-1", "protein_name": "Transcription initiation factor TFIID subunit", "gene_name": "taf9", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSSNETLPNSEQENNSKTDTKNDNKNIGDENKIIDTDKDMKDNDTINGKENGNININSNNNNNNNIDTDKEMKETSSIEEDDNNNNKNQNNNNNNNIKEENDNLTELKNNNNKENKENKEETIKEDKEKENNKEPVKNKEETNNINNNNNKNNNSDNINNNNNNNSKETLNKISSMSKVSLTSESSEINGQVNTGVVNNNTNIDITQTNLDEPRDSRVIKSILKTMGIQAHEPRVVNQLLEFMYKYVFEVLQDAMIYGEHSGKTDIDVSDVRLSIQSRVNYQISTPPPRELLLSIAEEKNKTPLPPIPNRYGVFLPPDEYCLTNPNYQANPTKPVFQPVQPLVGNTSRGNYNKKQSDKQVSIKFNSMSNNSTTTTTTTPPTIGSQNGTTIVSPPNLGSLGTTTTTTTTTITPPPPILPLSSNIKPPTLSIPSSITSPPTVTTKNTSTPIIGLGSTTVAPPKTSSSSSTIAPPVLSLPTSITSPPTVTASSTTTTTTAPTTTSPTIPSLSSPTTAATTITVKKEDVKMDDFDDFDGQMKDDITPSSTPQQPSQPTESETTTTATATTTPAVTTTTIPPTTTSTTPPTTATTSTTPPPSTTTTSTPPTTSTTPPPQIKEEK", "length": 619 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55B17-1", "protein_name": "Amine oxidase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MYKKILLIFALFILVNINFASSEFKKNETESANLKSLYASYLMKNNNNTKYNNNDNSNNTNIYNDSVTKNKSKNKNELTVGIIGGGIAGLYAGMLFIKSMIFDDLGIDYTILEANKERVGGRVYTHKFDDHKYSYTDLGAMRIPLTPLMDRIVSNQNYSLFSKLAKGGYQIPTVPFLISVNNEISYYNGIRVLKGSPVLNPSDPFNYSDSNNGGPGKGIPDEYANRTVDSLILPVFYQFINNLTVDFYNGFKQMLKYDSYSARDYLKTFHNYPNSVIEYIENLSTISGRLDQTSITELLMSVFDFSGEKFVCVEGGTGLIVKSMSQIIKKKVEMGSFVTKISKSFDKKNNEIDGLNVEVVRDSNFGGSDTEILKFKHVISTTTLPALQRIDTSDLKLPLKLKVAIRSLKYTGAIKLAINFKYRWWEDSEFMSGKPIRGGSSNTDLLLRQVVYPSYGINNGTKGVSGVLLASYSGGLESIRISSMIGKKDKERKLLNIVLRDLAEIHNVDLKKLKNLYKDHFFQSWDNDEFSSGAFALFSTSQYTELFPSTGQSHVDGRFHLSGELTSVHHAWMIGGLNSAYRSVDLILKNEGFEDLRIKLRNNWGTIEQAEYPSLDWYKYDSDINHYKLY", "length": 630 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55BT6-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKLLYIVVFLLFAIKLCCSEYCGETYCVENRNCYSFIGCRNSTCLYETIDLDDEVDCTVDTCSDRYGVKNTPNNSLCPPENLCDMFLCDTQSGCVAIPKVNCPAPNPCQIPLGCNRETGICEYDEIDCHDDNECTNDYCDPILGECVHFSNDTICSNKASNFSTCVLSGVCGEFGCKYVEDNCNDGNPCTDDYCDFKNGCVSQKNDWNCDSLSACSEGICTDNGCVQQEVDCDDDNPCSEDFCHPLFGCGSILNDTICTNGNKCVNSTCTEDGCSLPVPIVCQDGNPCSDDTCNPSTGCQFTLNNSNCNDGKKCTIDQCGLNGCTHTNITCPPKRVVDIILIGLICRNHYCDQSTGNCVPDMNSVSLLCI", "length": 370 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55C69-1", "protein_name": "Chromo domain-containing protein", "gene_name": "hcpC", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGKTNKKKIEEESEEEEAGDVFEVEKILDKRVQHGRIQYNIRWKGFSADYDTWEDEANVVGCPELVREFESSRIKEKKKNRKRKNVIIDEDPTEEISSSLSSILSSPQPQPPPPLQLTNHSPASSELAITTNTFLISNCTSTSNKTKISIENEEIIKNDHARYGVPYVEGIGFENGDCVDEIVGCKPFGENNLLYFFIRWRGKEKLSWVSNESIKQKEPLQLIEFYESRLKFGYKGEEN", "length": 239 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55CH5-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIAKTQIKCTTIYAPAKSNERHEWYKENLTEEILHSDIITGDFNVDCSVDNNLNKYIKTIFDEFEFTEIKNGITFPRNKSTIDRVFVSKKILHLNPIVTTKEIKLKSDHNMVIIELKIPEYEQQKKGERLWRQNLETLKMNSTSLKINKTIKYYNKKFEENTSKWYKLNICEQWLKLKDEIKKLSINIEIRESNKTKNKLKELAEKLETAKDSRAIFLKEEINNILKEQVRIKQANQTNTHINNKETPSKYLTRRLKVQRKTNEIPQILDPSNNCLVTKHEDILEVARRYYENLYQKRECNEDTHHELLKTFNKRIDQKILDEINQPIEGYEIRLGIEKIQEGKAPGKDGLLPTFYKNHINEILPIISKLYNHFWNTTIPKDFKQGILITIYKNKGDPNNLDNYRPITLLNVDYKIYSKIINNRILKFLNKIISPFQTGFVPRRLLHDNIITLNSTIEIIKREINTKEDMEPIITFYDFEKAFDSISHNAILRTLAHLKLPLKMVLTIMNLLNESETSVYINNSLSKSFTSKRGTKQGDPISPTIFALVVECMATTIINDRCINGVTKETIKILQFADDTATIAYNFMDHFLMNEWIKKFCQATSAKINQTKCSCITFKWNTRTLYTVIKSNERYLGFDFNNKGIKSKINTISDNIRAKLVTWNSTSSTYMGRLIMAKTYALSQLTFHTYINTTPQHNSIENNIVKFVFNTKSKNSLSLQRRQNNYINGGLNLWNLKTRELAQKAWLFERYLHQRVSNTPSSYIKLWEEELKNNNNNKTTTKQNQLQLHWQCKQAWTQLKTPQNKQTHYEHLPKLKKIYEDMMTTQSPEHNKFIPTPGQKEIMTKINSKHLPFKEIKKIINMKGRDLLWRYTLKALPKIYNMPCQQCGEDETSEHIFFNCKAHIKNTQEIFNYTLTKCGHTTHTWNVKILNHLQIALVANLIAIIFDKIWHKRNKLIHDEKEIIIHRQQVIRELIKTQRAAWDRTQAVINKTLRIKSKQRPEEQNKLDSLISLKLLQFSRQWNSPLHAIELPKHLKKNNNSLSTFYK", "length": 1047 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55CH7-1", "protein_name": "SsDNA-binding transcriptional regulator", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIFKITRTKRRWTKNQKKILVMKVVEKKVVVKKSKTPNTSPSSSSSSSSSSSSSSSSSSTNDKSFNLSDKRKISYSNFKGLERIDIREFFEDKSGELKPSSKGISLTREQLVVILENGDTIKDWIKESK", "length": 129 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55CJ7-1", "protein_name": "diaminopimelate epimerase", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEPSIDNKPSFRINFTKMHGAGNDFVVFEKNKVERLNGDKSTVTFEEIVGFTTKIAHRKLGIGFDQLIVIDDNPIDKNAAYGMDVINCDGNIEVMCGNGVRCFSKYIVDNKVLSKNLKEQLNFDGDDDIEQIIETKSGIVKTYPLLKHHLNNKDNDVIMVKVNMGTPKVSRFINEIDRHIPKVLTNQSPIESYMYTIDIGLPYCSKLECVYVTVGGNQCVVFIDRNIELGYLDSSYGDHTKFSTIDFKEISDIIQSNVNGFDDIPNVEFVIQSPQDKLENKVISRVVERGNGETLACGTGACGVAISSILKGYCNENTEITVEMPGGKLLIQWNPNNEIFKTGPATSVFKSQILI", "length": 355 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55CV8-1", "protein_name": "Lipocalin/cytosolic fatty-acid binding domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MELLVGGTILGALTYAYSSLKRTIPEGAHACSPFYPEKYVGKWYEIARLDFYYERDMNNVSAEYTLNKDGTISVINSGYNYVEKKRESVNGKALFVHGSDEAMLKVSFFGPFYAGYNVIAIDPDYKYALVAGRSLDYLWILSRETSIPDHIKKQYLELAESIGYNTSKLIWTEHDNINNKKD", "length": 182 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55D49-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIKIMTWNCQGCSTIKSMNQTKNTINLIKPDISILTETNLKKDQNLAQIKNHYSTGGKGKEARGKGVMAINHLEQIEIKNLEEKEGRILKFTAILNNMEINIICIYAPASYDRRKGWFSNNISLEDLEQADIVTGDFNINKYAKIKFKDGSSDKRKFTENETIEFLMMEVGLTEILPNSTTKTTFKDKLIDRTFLSTKMHQLNHSYKIIDKINKSDHNIVVMDFKIPNFTKIYKSPLWKMNSIIIKEDKTIKKIEKIIDHYQETKRKNINITEYWIKFKKKIKKQCITTEKKRILERKKTLSNLANEHTKTKNKYEKETISNEITILQEEERIDRMIKSSINYINNKEIASNLLTSILKKRDSSSQIHRIKNPSNGEIETEQKEITDCFRKYYETLFKEKECDQETHTELLSTWNPPIDKKKLTEMEDRIEEYEVKLAIEKIAEGKSPGEDGITSSFYKIHQHKLIPILTELFNFFLNNEIPTEFKNGILTSIYKGKGDVLEISNRRPITLLNVDYKIYSKIINNRILKILPNIISKYQNGFIPGRLLHNNIIALDLAMEKSDRNTIITFYDFEKAFDSISHKALIRTLNHLKFPRKITNTILSMLTNTNIRVMVNGQLSESFRAGRGTKQGDPISPTLFAIVCECLSTSIRKDNTIIGIKLNQNNSMKIGQYADDTVTLASNIDDADKMDMKVIKFCQATAAKINDNKCVCITKNPKIKTKYKTIGAKEEERYLGFFFNRKGVISKVDDTVNKLENLTKCYSSVSSTLKGRITILKSYLLSQLTFQLYINEINDIKKLENVNANMLFKGDRWAISKERSRRDYEIGGLELWNMATRSNAQKAWIYEQYLREKDDQNCPPHMEVWKSEKENSLSRIHIKCWKAWKLLHHPRERITLKLNQVKPKYENKQKLKVIYRNMMDIKYKGWNKHQPTTGQKLIQKNINHPILPFREARSITTIKGRDLAWRYLLKALPKHHGENCHSCKEEESSMHIFFECKSIKQNIDSIYQKVCKDSNNTYHGPWSEKVLGKLLTPFSSNLIGAIMESIWYRRNQIKFNDNTTIITENQIIHKIKKARDAEWDRTRKIVEKQLRQELRCTDNRESINRTASIKRRLEKFSHNWNSKLMTINIPEHFIPYCSYNTNYS", "length": 1144 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55D57-1", "protein_name": "J domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIQVKNKIKIISILITLFILTINQVVECKSSLYYSILNDYEKGIDYYKILNVTKDSTYSEIKKSFRKLSLKHHPDRNVEKSSHSLYILLNQAHSVLTTDETRKEYDELLVNGIPWHENYYGKYAYRYTGISHDLRHVLLGLIIVITIGKFVYQYNKHHSMIKRAKQTDQYKKRLAQLDGDEDEIQLVIQGADKPTISSLFIIQLFFIFPFKILKSIYTFIFINKFKFIQKTDEEKEEEYRLKMGYTKEDWEYHKKKSIERMEKLKQSGKYKKYLRSKNK", "length": 279 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55E25-1", "protein_name": "DRBM domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSNKSHTSEKVQLNEFLQKKKQPIPIYHTESKGSEHNKDFKSIVVVNGKQIESDWKKSKKESEKDCAKNILEFIETLDGYPIYFTPFSKDPPQNNKKIYDEKLQAVYNSVSSGIEGLNNNSFFTKIENNNNNSSSNNNNNLDHNHSNDSSHTSTDNNDNNSNNHNNNNNNQINIDLTMENVNISQSKTITNEGTLNNDNDNNNNSIQQQQHQPQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQCFDKDKTNLKKKKKIPFSYNTDLIEHIDLFKRQDFPQTYPSRTTYTDTGHTQQLQKQVFLLTEKIGLMELFYKKQIRVILKSHHNLETELSALKSFVEDCSVTPIEGLELYSIPVPLNPNAKPSAGTTPVLSKSETQNEIIQPTKPPTKPPASCLIKKKIPNVNMKATNKTTTTTSTSTSNSSTTIKTTDSFKNTTNNQHPNTLKPMVSKINQQTSDFIFPLPKPIIRRNPIGNGNLEKKIEKKNSKPNTIVLGVDTQSQSKTKITPSPTTPPPETTPTTPTTTATPTTPTTPTTPTTTATPPPTTTATPPPTTTATPPPTATTPPPTTATTTPPPPPIIATTKTTATATATTIPIDLNEIQIPIRSPQDLTVNQSMISTAMMIASAAQRNPKLTMKLKRKLEESPTLMSKLQKIQFEKEEEILCSQDLHSPIMSPQSPTHQPKTLEPLSPTKKSTQKSPPPTSPSPIVTRARASSNLLPIQNLISKK", "length": 733 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55E47-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIAKTQIKCTTIYAPAKSNERHEWYKENLTEEILHSDIITGDFNVDCSVDNNLNKYIKTIFDEFEFTEIKNGITFPRNKSTIDRVFVSKKILHLNPIVTTKEIKLKSDHNMVIIELKIPEYEQQKKGERLWRQNLETLKMNSTSLKINKTIKYYNKKFEENTSKWYKLNICEQWLKLKDEIKKLSINIEIRESNKTKNKLKELAEKLETAKDSRAIFLKEEINNILKEQVRIKQANQTNTHINNKETPSKYLTRRLKVQRKTNEIPQILDPSNNCLVTKNEDILEVARRYYENLYQKRECNEDTHHELLKTFNKRIDQKILDEINQPIEEYEIRLGIEKIQEGKAPGKDGLLPTFYKNHINEILPIISKLYNHFWNTTIPKDFKQGILITIYKNKGDPNNLDNYRPITLLNVDYKIYSKIINNRILKFLNKIISPFQTGFVPRRLLHDNIITLNSTIEIIKREINTKEDMEPIITFYDFEKAFDSISHNAILRTLAHLKLPLKMVLTIMNLLNESETSVYINNSLSKSFTSKRGTKQGDPISPTIFALVVECMATTIINDRCINGVTKETIKILQFADDTATIAYNFMDHFLMNEWIKKFCQATSAKINQTKCSCITFKWNTRTLYTVIKSNERYLGFDFNNKGIKSKINTISDNIRAKLVTWNSTSSTYMGRLIMAKTYALSQLTFHTYINTTPQHNSIENNIVKFVFNTKSKNSLSLQRRQNNYINGGLNLWNLKTRELAQKAWLFERYLHQRVSNTPSSYIKLWEEELKNNNNNKTTTKQNQLQLHWQCKQAWTQLKTPQNKQTHYEHLPKLKKIYEDMMTTQSPEHNKFIPTPGQKEIMTKINSKHLPFKEIKKIINMKGRDLLWRYTLKALPKIYNMPCQQCGEDETSEHIFFNCKAHIKNTQEIFNYTLTKSGHTTHTWNVKILNHLQIALVANLIAIIFDKIWHKRNKLIHDEKEIIIHRQQVIRELIKTQRAAWDRTQAVINKTLRIKSKQRPEEQNKLDSLISLKLLQFSRQWNSPLHAIELPKHLKKYNNSLSTFYK", "length": 1047 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55E48-1", "protein_name": "thioredoxin-dependent peroxiredoxin", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTKLKVGNIAPDFEAKNYLGQIVTLKEFKEKSQPIVLYFYPKDNSPECQKSCEFRDKYQKSIEAGAEVIGVSSDGEDSHKSFVSKYSLPFTLLTDKHSKLAKLYGVNGILLPGRKTFIIDKHGFMAVFMMVYSVQLLMSMNL", "length": 142 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55ED8-1", "protein_name": "Decapping nuclease", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKQTLNVIGLINFIKKQRSFNKSPITITKPLEITRFSYEGNQLFPAKLKKFKNPTIDSDLLVGFQGPDSIESDSQTPLSLVLNKLIETKHDVSKSNFISFRNSFRKLFESMYDSEKWNIQVQRINSTIHLGMDNPTQDFHQLKNFHLKSMYSGNYFEKISTIDNNNNPNDNKHKYCSIIQSKLFNNNFILACEIDCWKKSIQNNNNNQNNNNNENNNNDDDDENYNIDDYVELKTSRDIEDSKANYQFRSKKLIRIWFQAYIAGVSKIFLGIRNDDFFLKKCLNFNTHDLPNQAINWNKDEMLIYGNEILEFIKNNTCSGKSYTLSFNYPIISLVESDSINIINDQYLQYYLNIPKNFENNYNQNNNQNNNNNNNNENNSDDTKNNNIQNNNENNNIQNNNENNNQNNNEKNQKRNFGEEKEIKGDENEERLSKKQKKLE", "length": 440 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55EZ2-1", "protein_name": "Reverse transcriptase domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIAKTQIKCTTIYAPAKSNERHEWYKENLTEEILHSDIITGDFNVDCSVDNNLNKYIKTIFDEFEFTEIKNGITFPRNKSTIDRVFVSKKILHLNPIVTTKEIKLKSDHNMVIIELKIPEYEQQKKGERLWRQNLETLKMNSTSLKINKTIKYYNKKFEENTSKWYKLNICEQWLKLKDEIKKLSINIEIRESNKTKNKLKELAEKLETAKDSRAIFLKEEINNILKEQVRIKQANQTNTHINNKETPSKYLTRRLKVQRKTNEIPQILDPSNNCLVTKNEDILEVARRYYENLYQKRECNEDTHHELLKTFNKRIDQKILDEINQPIEEYEIRLGIEKIQEGKAPGKDGLLPTFYKNHINEILPIISKLYNHFWNTTIPKDFKQGILITIYKNKGDPNNLDNYRPITLLNVDYKIYSKIINNRILKFLNKIISPFQTGFVPRRLLHDNIITLNSTIEIIKREINTKEDMEPIITFYDFEKAFDSISHNAILRTLAHLKLPLKMVLTIMNLLNESETSVYINNSLSKSFTSKRGTKQGDPISPTIFALVVECMATTIINDRCINGVTKETIKILQFADDTATIAYNFMDHFLMNEWIKKFCQATSAKINQTKCSCITFKWNTRTLYTVIKSNERYLGFDFNNKGIKSKINTISDNIRAKLVTWNSTSSTYMGRLIMAKTYALSQLTFHTYINTTPQHNSIENNIVKFVFNTKSKNSLSLQRRQNNYINGGLNLWNLKTRELAQKAWLFERYLHQRVSNTPSSYIKLWEEELKNNNNNKTTTKQNQLQLHWQCKQAWTQLKTPQNKQTHYEHLPKLKKIYEDMMTTQSPEHNKFIPTPGQKEIMTKINSKHLPFKEIKKIINMKGRDLLWRYTLKALPKIYNMPCQQCGEDETSEHIFFNCKAHIKNTQEIFNYTLTKCGHTTHTWNVKILNHLQIALVANLIAIIFDKIWHKRNKLIHDEKEIIIHRQQVIRELIKTQRAAWDRTQAVINKTLRIKSKQRPEEQNKLDSLISLKLLQFSRQWNSPLHAIELPKHLKKYNNSLSTFYK", "length": 1047 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55F94-1", "protein_name": "Dynamin-like protein A", "gene_name": "dlpA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSVFKKKDKSDDKKKKHDEETPQGTFQPASQSTSNTNLNSLASSVNNGASVGSTNGSTPNNSNGSTPTYNHNNSAEELEKQKKEEDEKRKKSELEAAAAVVAKKKEDEEKQRKEQVELERKRRDEEIRRTNAAAANAANKELNEQVEISSLEQMGKLDPSSTIHDMFSFFPNEVYNSYEKLQYFSRDLNTAVSHPEIVFVGPRSSGKSSLIEAFIGRALNIVGGGNIVGVGGSNANGCSKRVLYLQFTNNIDFEVPKVTIKKDNTIKEFDHDIIVSIEQLNENLAKRNQLTNDYIEEPIYVSIESRTTLNLTLIDSPGLLFDQSQAESNKIESIVSSLLRPSHRLIIAVESCSQDWKSMSMGQYLKKIDPELSRSTFVFTKFHHTVRGFSSTRDINKYLSGTVPDIKGFFVTLPNHQVRASYSEANRFQEKIYQAHKRDMHALEQLQYDKRYERTIGVAPLRRYILNIVWKSYQDTIPRILKHLRSKRQTAEATLNELQKQSSSLDSTKLRSIASNYTVTFLQITEKLLSGTSEGNPSANGQTLDEEKSQQGDCGEWVDAYKEAIYIDPEEWNIPYWSSKLYGGQQLERLMAEFKAVCDNSKISEVKMDDIATASGINKLNNIPNYAWAASDLTSLISRDTFVPLIEQLCERAMYIMKRLTDIADKVIDSRRKSRCIGSSPFGGNGLNNINSGGNNGININDRLSNTDMDSLDQYPFFTHHVKNLYYDFVHRAAKGCKEKCMDEFYSSRTIYWELTEHPDSSLPSIRNDHHETKTAVCQLATKLFDSIRQRITKNVLLKLYNFFLVPMQTDLWNEIQAQITCLSNEQLEQLFEVQATREQLKQEEKKQQQILEKYSQIDEQFLKAASLFCRPLSNPTPSA", "length": 880 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55FX4-1", "protein_name": "SET domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDINSNHIKKINDFKDKGNKEFNKEKNKDKLNKRAITYFQLGIKYFNDEKHKIEINDQINKLISILYSNLSLMYLKGDEIILSLEASNKSIEFNNQNSKAFYYQSICKSYLCDYKGSMESIDKAISISKQDEKVVQQRNRLIEITNNKVKEDVYFENVLKNQKLENVAYENSIEKGRYLISKRLIKRGEEILRIAPFSFSLNGKYVSKFCGVCYQKKSIDNLLKCKDCDDFAICKECKAPNEPLSKYHPNDLCVLYKLNNEYYKMNNFEIANEDNKERGLTDERRLYINTIYNIFKNKTNNKAVVEVDNAISSSVIDVLNLSKKLLNHTNESQRAYSDSTKMKTDILELIFKSFYGANTLKKDEISNIIRIVDCNSHGYSDVISQKKKASGLYPFSCYTNHSCIPNSDYFIDKHGVMVLYASSDIQESEAITISYIYFLNRVEKRRKDLLNGHNFFCTCDQCSFQSSLTEEVCDKCNEIIPSTIGNSNLVYKEPKSLKETGFNYICPKGHTKSSLVYDIDNDQLYPTIAENYSKCKDLRNFRKINIFKEMLENRDFVKKLTPREFEVTPLAKYIANPKKSNSMLFEELINLVRGSVECGLTKSIEESNYSTYLVYDYYDLYKSLLLESKPQILKLNSIRDIIIKLLTPMVYNQNKPRIDKKLNKHLSNKINLKKNK", "length": 676 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55G93-1", "protein_name": "Tubulin-specific chaperone D", "gene_name": "tbcd", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MENSEDISLNSSEKSIESSVVNLEDQQQSQQQTQQQTCQKTFVQEAPELTILIDKLIQLKHSNKDELISNTTRIIYIIDQYLEQPTLLDIHLNDIIQPLINFIKSNYINNSNNNNTTTTTTTIMTETEIVIKKLSIKNSFRIIYVLSKVRGFKTIVKLFQHEAIDLLPVLDQLEISYHQWVNINKQRDRLNEISVSYSSGINLKNYIKPEEESEQEVVDENNNNINNNHNIDDEYNENIISWEEVYVLALWVSLLVIIPFKFSSLDSASSGTASAAGDGGDGDGDGQLKSISSRILKLGKLALSDVSKIRDSFSELLSKLLNRPDMKFEQKQFIKWCTNSIQLISNNNNNNNQNNSSNNNILLIIGIYSTLATMFKKGNRLDFLPIDMNLYEKIMEANKYLSLSGSERITKKIFLKLLQRIAIIMLPPVSASWRYQKIIKPLLLKGELIKQINNNNNNNNNENNNEEGEEEEEEIPEEIDEILEEIMKSLKDKDTIIRWTSAKAIGRIVNLLPKDMGDQVIGLVIDQMFEKNEFIDADPSAWHGGCLALAELARRGLLLPERLDVVVPLVIRALFFDIIKGTYSIGSHVRDSACYLCWALARTYHNSILSPYLLPICRNLVVVSLYDREINCRKSASAAFQEMVGRHQGLVPNGIEIVTSADFFTVGNKNNSFTSLTTFIGKFQIDYYPIVIKHLATIKIYNWDLEIRQLASKSIHLLTNINPNDIVSNYLPLIIPNTQSDLVHVKHGASLAISEILISLFENNNINLLSDNLKMMILMTIKNTKNEKLFKGKGGVLIRIGMCKIIYSICLVEFSLDKNLSEIKKPTESTSTNGNEDRAAALKLKIAMLKAKTASQINKPIITPPSSKSTTNNNNNNNNNNLNDNEIAFNIILGYLNENLNHPNEEVQKEASKAFELLFSKYISSNEKISLLLELIDSHCKTLKFDINRSARRGSSLLLGSLPFNSANLSYDLLSKVVNELILSIFQDDPKFKDIETRVNSISSLYKIGIYILNLIFKNQENEQKEEEDFKKSKNYNLFIKIWNCLGLATNDYSIDKRGDIGSWVRELSCKVLFDFIKFIITNQNSSTTTTTASTTDLSIENLINEKMITEFICKLFQLSGEKLDKIRDVACKIIHELLWIENPSSINNIPHKEELKKIIVKDQDVHFNWFRTEESLPLICKVLKFNCYLYPLLFGLFSSLGGTSKYLINDSIQSIKQYFSSFDNDEKERFEKIISFSKAILEITNNTTQRMIQPTFRSIYNLLSTHIFDFLIINNLNEQSIFETILFNCYQIIESNQDDIYLLLNSIELFSYFFIQFENNNNEYIKDYSLKALLLLLSNLKYPKVRKLASDQLKKSTRLFINNNGDDETPSLIKSLIFNTKWDDSVDLIIEPLKSLLLLLNQKHLLELLSENPTKKPIPLAPPITSIEELKDKIQNPHKQSDDNNNNNNGELINNNTENNNNNNFDDNLPEDSQDLMEI", "length": 1480 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55GP8-1", "protein_name": "Rho GTPase-activating protein gacO", "gene_name": "gacO", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSKLPPPPVQSSPQGFQLPSLHSVQLKPVRPPPQPTQQQLASNTSPREVGTSLSPQSPSNNINPSSSSSSPSSSIRQSPSSSPNVARKVPPTPTNNNGGPPTTTTTTTTTMPPPPAFIKKLSPSSSPILPKRIVSSPPLNGNTAPPPPPIVHLPPPPPTNLPPPPTLSPSSSTTTSPSSSSLNLSGGVPLPPRILRNSDGSANNNNNSNNNSNNNINSLNLSTSGGIPPPPSFFNNNNNNNNNSGSFVNSASSNGSPSLQSQNSVGYFKPPPPPVPTRSASLDPKQMGQFIKPQQNQNNSNNINNINNNNNNIILPPPPNININNNNFVPYIPSNNNQQQSTTPPPIVSISPLKRNSIDNSVVNKRLSQDLNTMLVNRLQHGLSPPVATPFFDDKILGSASKSAELKEKRDQEERERRERERIKKEKEDSEKKEKKEKKGKEEQEKKDKKKKEEQEKKDKKKKEEEEKKSKSSSSSSSSSKKSSSDNTIVNQNIFNNTLSQIMENQRDAQSLSPSSLPYPLILKLLTESIMSLNGPYTEGIFRITGSGTEVNRLKKQINEHDFSLDTQDPHVLAGLLKLWLRELVHPIIPSELYNDAIKSRSKEEVSRIISLIPDQNKEVLNFLIPFLKNVSQPHYAQYSKMDIDNVAMVFSPGLLRSTVLTTDLLLNSQYEKDFVKCLIEMSP", "length": 684 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q55GR8-1", "protein_name": "Thiamin pyrophosphokinase thiamin-binding domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEKQEEEVQQQQQQQQQQQQPDKNNKETITWDVAEYGGYLFDKKLKAHNPLNHQMPLQYHHSQSTPHIPSSLSTSSTTSIKKPSSSLSDDESGGSSSSTPHSSNTPRKQFSFDDHCALILANQKLPKKLVDYFWDKCSVRICADGGANRLYSLGTKINQSSRWIPDYIKGDLDSLHEGVSDFFSKKGSSIVLDSSQDTSDLQKCFELIIDLEKGSGIKYRKIFILGGLGGSFSHEFANVNTLFDHPGRKIILASKDNLAWLLSSTYNHNIICRSETKCSLIPLSSKASQVTTSGLKWNLVKQSLNFGELISTSNVSLDNKVCVETSNPLIFIVDINP", "length": 337 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q561S0-1", "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "gene_name": "Ndufa10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALRLLRLVPASASARGLAAGAQRVGRIHTSVHCKLRYGLLASILGDKTTKKLHEYSRVITVDGNICSGKNKLARDIAEQLGMKHYPEAGIQYSSSTTGDGRPLDIEFSGSCSLEKFYDNPKSNDGNSYRLQSWLYASRLLQYSDALEHLLSTGQGVVLERSIYSDFVFLEAMYNQGFIRKQCVDHYNEIKRLTLPEYLPPHAVIYIDVPVSEIQSRIQKKGDPHEMKVTSAYLQDIEDAYKKTFLPKMSEICEVLVYSSWEAEDSTKVVEDIEYLNYNKGPWLKQDDRTFHNLRMLVQDKREVLNYTTVPVYLPEITIGAHQGSRIYDSFRELPGRKYAPGYNADVGDKWIWLK", "length": 355 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q568T5-1", "protein_name": "Chondrolectin", "gene_name": "chodl", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRATLRILCALTFLVSCSRGARVVSGQTVCQGNPEHPCYKIAYFKDVSSRVAFWEALQACEMDGGSLLSIENTAEQKHIEHLLRELSVSSSTGPASITDGDFWIGLTREEGDNAQEPGAFASCPNLYRWTDGSVSLFRNWYADEPSCGGEACVVMYHQPTALAGPGGPYLYQWNDDRCNMKHNFICKYEPESHLVKVQSDRPGGHDVDLSTEDKEDRRTPPTDEDESPRLIIAGPSSMLLIYVIIPTIPLLLLILVASGTCCFQMLSKSKPRTKTSVNQSTLWISKTPKIDSGMEV", "length": 296 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5HYN5-1", "protein_name": "Cancer/testis antigen family 45 member A1", "gene_name": "CT45A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTDKTEKVAVDPETVFKRPRECDSPSYQKRQRMALLARKQGAGDSLIAGSAMSKAKKLMTGHAIPPSQLDSQIDDFTGFSKDRMMQKPGSNAPVGGNVTSSFSGDDLECRETASSPKSQREINADIKRKLVKELRCVGQKYEKIFEMLEGVQGPTAVRKRFFESIIKEAARCMRRDFVKHLKKKLKRMI", "length": 189 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5I0J8-1", "protein_name": "PHD finger protein 11-like", "gene_name": "Phf11l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQEEPGGSNSVLNGDANSDKKMEKWTCALCPEGHDWSVIYFEPSSNIAAHENCLLYSSGLVECGPHDPRNPARSFAVKSVKKEIWRGRRLKCSFCNNKGATVGCDLQSCPKNYHLHCAKEDRAILQVDEDYGTYKLFCQRHAPGGQEPTQVDAAVKASFLKKCLEAGLLTELFEQIQQKMISIHGRFMDDTASESDYEGIKILLFDCGLFKDTLIKFEEAIKSKACECEERLNQMKQQLELLADLQQNLRSFQECGVLDPSGSTSGSLLPPEDHQCRCQESPEVQAGSGDSL", "length": 293 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5J3E6-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vom1r12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSKDLAIGVIFILQCSMGILRHFILLSYYLMLHYNKHSLKPIDLILMNMFIANFLIIFPKSMLQTVEAFGIKLLFSVFVCKFLLYIERVGRSVSIATVCLLSVFQAITISPRNSCLYGLKVKVPKYISLSIFLCWALYFVVNMILPVYAYIKWSSNNMTYKRTLKYCFSVGHDEFTGSFFTILFVFPEVFLAILIVWSGSSMVVILYRHKQQVQHIYCNYASTRTSPESRATKSIVVLVSVFICFYSISSILYGCIALFCDNSWSLINIANIISLCFPVLGSFVVSHNPDFPRFSLSWIRNTRRV", "length": 306 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5J3E9-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vom1r15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVNDRMESKDLAVGVIFILQCSMGILRHFTLLSYYLMLHYNKHTLKPIDLILMNMFIANFLLIFSKSVLQTVEIFGMELFFNVFVCKFLLYIERVGRSVSVATVCLLSVFQAITISPRNSCLNGLKVKVPKYINLSIFFCWPLYFVINMILPVYGCIKWNSNNMTYKRSVKYCFSIGHDELTSSIFTILFVFPEVFLAILIVLSGSSMVVTLYRHKQQVQHIYCNYACTRTSPESRATKSIVVLVSVFICFYSVSSILYGCIALFCDDSWWLINIAHIISLCFPIFGSFLVSHNPALSRFSLSWIKNTRRV", "length": 311 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5J3F0-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "LOC100911184", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDFWNLAIRIIFLSQIIIGILGNVSLLFYYLVLYYREFTLKSTELILMHLMVANIIIIFSAGVPQTMTIWGMKQFLNDFGCKLLLYIHAVGRSVSICTTCLLSVFQAMTIRPQKFCGNDHKVTMERYLGCFISFLWVLYFLVNFIFLVYTYIKKNSNNETRKRDFGYCSTVGSDKISDSLYATLVMCPEVFFSVLIAWSSGSMIVILYRHKQKVKYIYSTHVSRRDYPESRATQNILAQMFTFLAFYTLSSTLRGSIALLSNHSWWLMNINHFTSLCFPSFGPFVLMSHYSIVSRFILFWLRKNCSNFLL", "length": 310 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5JQC4-1", "protein_name": "Cancer/testis antigen 47A", "gene_name": "CT47A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSATGDRHPTQGDQEAPVSQEGAQAEAAGAGNQEGGDSGPDSSDVVPAAEVVGVAGPVEGLGEEEGEQAAGLAAVPRGGSAEEDSDIGPATEEEEEEEGNEAANFDLAVVARRYPASGIHFVLLDMVHSLLHRLSHNDHILIENRQLSRLMVGPHAAARNLWGNLPPLLLPQRLGAGAAARAGEGLGLIQEAASVPEPAVPADLAEMAREPAEEAAEEKLSEEATEEPDAEEPATEEPTAQEATAPEEVTKSQPEKWDEEAQDAAGEEEKEQEKEKDAENKVKNSKGT", "length": 288 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5QNN9-1", "protein_name": "Trace amine associated receptor 12e", "gene_name": "taar12e", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMSLNETQTENILLCYPLLSNSCPKLHRLAVVQVGLYVFLLLMILTTVFGNLLIIISISHFKHLQSPTHLIVRSLAACDCLLGLLVMPYSMVRSVEGCWYLGDVVCKVHSSLDMTFCISSLLHLGLISVDRYWAICDPLRYRLRVTNITVTVFIVFIWLFSFVYSFYVVFSGVNTVGLETFIMQVYCVGSCVLYFNKQWGLICPILVFFLPGAIMSSLYMKIFHVARKHAKVMSERVTGGLKSQSSAQRERKAAKILAIVMGVFLFCWLPFFTVNALDPFFNFFTPADIFDAVIWFAYLNSTCNPLIYGFFYPCFQKAFKILIFTYICGVRNLDTFA", "length": 337 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5QNP0-1", "protein_name": "Trace amine associated receptor 12g", "gene_name": "taar12g", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTSNESENIQLCYPLLSNSCPKLHRLAVVQVGLYICLLLMILTTVFGNLLIIISISHFKHLQSPTHLIVRSLAACDCLLGSLVMPNSMVRSVEGCWYLGDVVCKVHSSLDMTLCISSLLHLGLISVDRYLAICDPLRYRIRVTNTTVTVFTVFIWLFSVVYSFYVKFSGITAVGLEMLILQTYCVGRCVVFFNKQWGLICPVLAFFLPGAIMSSLYMKIFHVARKQAKVISERVTGGLKSQSSAQRERKAAKTLAIVMGVFLFCWMPFFTLTALDPFFNFLSSADVFDALFWFAYLNSACNPLIYGFFYPCFQKAFKILIFTYICGVKKANTLTFE", "length": 336 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5R1F6-1", "protein_name": "T cell receptor alpha variable 5N-4", "gene_name": "Trav5d-4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTYAPTLFMFLWLQLDGMSQGEQVEQLPSILRVQEGSSASINCTYENSASNYFPWYKQEPGENPKLIIDIRSNMERKQTQGLIVLLDKKAKRFSLHITDTQPGDSAMYFCAAS", "length": 114 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5RKI7-1", "protein_name": "Solute carrier family 7 member 13", "gene_name": "Slc7a13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAMDIEKKIYLKRQLGYFWGTNFLIINIIGAGIFVSPKGVLQYSSMNVGVSLCVWVFCAVLSMTSTLCAAEIGITFPYTVAHYYFLKRCFGPFVAFLRLWTSLFTGPGVLASQALLLAEYGIQPFYPSCSAPAVPKKCLALAMLWIVGILNSRGVKELSWLQTVSMVLKMGILSFISLSGLFLLVTGRKENVRRLQNAFDAEFPEVSRLIEAIFQGYFAFSGGGSFTYVAGELKEPSKTIPRCIFTALPLVTVVYLLANLSYLTVLSPQELLSSDAVALTWTDRVIPQLTWSVPFAISASLFSNLVTSVFETSRTSYIASRNGQLPLLCSTLNVHSSPFIAVLLDVSMGSIAIVLTNLIELINYLFFVFSIWTVLSVIGILKLRYQEPNLHRPYKVFSPFLFITAAISLSMVLIPLIKSPKMQYIYVFLFFLGGLLFYVPLIHFKLKLIWFQKLTCYLQLLFNICIPDVSDEHVAEEES", "length": 479 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5XHX8-1", "protein_name": "Sperm microtubule associated protein 2", "gene_name": "Spmap2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGELGEHRSRSSLLSIPVLDTKTSGGSEYRESDGSLDLQSTLFEDHWLQSSQATTERNTDDPEEEIPPEEMVGEELPEVSNLEDSLRRDLEVEVVGMSHLSINERTTPTTSSAKCRKKKNHRLLELAKPKFNWQCLKDRTGRCCKGHVWISPRKTNLQFCLYWPSVYWTERFIEDTTLTITVPEVSRRVEELSRPKRFYQEYYNNNRTTPIWPIPRSTLEYQASNRLKRLATPKIRNNIWSINMSEVSQVSRAAQMAVPTPRTLRLAKPRAPATLLEEWDPMPKPKPYVSDYNRLLQLATPKALSEKCVPDRSPQWEVLNVTKNAVASSRIISLAQPKIRKDLNEGYNPYYISPASLVAQASPRIYELAVPKHITKKV", "length": 378 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q63550-1", "protein_name": "BPI fold containing family A, member 2F", "gene_name": "Bpifa2f", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFQLGSLVVLCGLLIGTSGSLFDIFQNPELDVESVWSEINYRIRYALETMDLDMLADYLSKRGIELKIKDLRILNLNHEVSPNGDEVTLKMPMALNASLSLPARDLTTDVSISMEAITSFAIEKDPKTGRRVLNMQRCSLNTDNTSISLLNRKSNFVNLALDSALYLIKRGLTLPVRRQLCPVLQLIISNTFHPDEISNPQTAIST", "length": 206 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q64583-1", "protein_name": "Cytochrome P450 2B15", "gene_name": "Cyp2b15", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELGVLLLLTFTVGFLLLLASQNRPKTHGHLPPGPRPLPFLGNLLQMNRRGLLRSFMQLQEKYGDVFTVHLGPRPVVILCGTDTIREALVDQAEAFSGRGTVAVLHPVVQGYGVIFANGERWKILRRFSLVTMRNFGMGKRSVEERIKEEAQCLVEELKKYKGALLNPTSIFQSIAANIICSIVFGERFDYKDHQFLRLLDLIYQTFSLMGSLSSQVFELFSGFLKYFPGVHKQISKNLQEILNYIDHSVEKHRATLDPNTPRDFINTYLLRMEKEKSNHHTEFHHQNLVISVLSLFFTGTETTSTTLRYSFLIMLKYPHVAEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFADLIPIGLPHRVTNDTMFLGYLLPKNTEVYPILSSALHDPRYFDHPDTFNPEHFLDVNGTLKKSEAFLPFSTGKRICLGEGIAQNELFIFFTAILQNFSLASPVAPEDIDLSPINSGISKIPSPYQIHFLSRCVG", "length": 495 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q66X01-1", "protein_name": "NACHT, LRR and PYD domains-containing protein 9C", "gene_name": "Nlrp9c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVDSSSYGLLQYFQKLSDEEFQRFKELLQKEQEKFKLKPLSWTKIKNTSKEDLVTQLYTHYPRQVWDMVLNLFLQVNRKDLSTMAQIERRDKQNKYKEFMKNLFQYIWTSETNTYMPDRSYNTIIDRQYKALLDIFDSESDPATAVVLGTRGKGKTVFLRKAMLDWASGVLLQNRFQYVFFFSVFSLNNTTELSLAELISSKLPECSETLDDILSNPKRILFVLDGFDYLKFDLELRTNLCNDWRKRLPTQNVLSSLLQKIMLPECSLLLELGESSCSKIIPLLQNPREIIMSGLSEQSIYFYCVSFFKIQLGVEVFKDLKKNEPLFTLCSNPSMLWMICSSLMWGHYSREEVISSSESTSAIHTIFIMSAFKSIFGLGSSKYKRFKLKTLCTLAVEGMWKQVYVFDSEDLRRNKISESDKTVWLKMKFLQIQGNNIMFYHSTLQWYFATLFYFLKQDKDTYHPVIGSLPQLLGEIYAHKQNQWTHAQTFFFGIATKHVITLLKPCFGNISFKTIRQEIIRYLKSLSQPECNEKLVHPKKLFFCLIENQEERFVSQVMNLFEEITVDISDSDDLGAAEYSLLRASKLKNLHLHIQKKVFSEIHDPEYGSLENFKLDQKFSAINWTMLSILFCNLHVLDLGSCHFNKKVIEVLCNSLSPTPNMPLTVFKLQRLLCSFMTNFGDGSLFCTFLQIPQLKYLNLYGTDLSNDVVEMLCSALKCSTCRVEELLLGKCDISSEACGIMATFLINSKVKHLSLVENPLKNKGVMFLCKMLKDPSCVLESLMLSYCCLTFIACGHLYEALLSNKHLSLLDLGSNFLEDIGVNLLCEALKYPNCTLKELWLPGCYLTSECCEEISAVLTCNKNLKTLKLGNNNIQDTGVKRLCEALCHPKCKVQCLGLDMCELSNDCCEDLALALITCNTLKSLNLDWNALHHSGLVMLCEALNHKKCKLNMLGLDKSSFSEESQTFLQAVEKKNNNLNVLHFPWVEDELKKRGVRLVWNSKN", "length": 1004 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q675C0-1", "protein_name": "Taste receptor type 2 member 102", "gene_name": "Tas2r102", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPVIYSFATLLIHVEFIFGNLSNGFIVLSNFWDWVIKRKLSTIDKILLTLAISRITLIWEIYTWFTSVYGPSSFAIGMKLQILYFTWILSSHFSLWFATALSIFYLLRIANCSWKIFLYLKWRLKQVIVGMLLASLVFLPGILTQRTLEERPYRYGGNTSEDSMETDFARFTELILFNLTIFSVIPFSLASISFLLLIFSLWKHLRKMQLSSRGHGDPSTKAHTNALRIMVSFLLLYSIYFLSLLLSWIAQKHHSKLVDIIGIITGLMYPSAHSFILILGNSKLMQTSLWILSHLRCRLKGENILNPSGNQVTSCYIFCIANKSVS", "length": 327 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q68FP3-1", "protein_name": "C-C motif chemokine 6", "gene_name": "Ccl6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRHSKTAISFFILVAVLGSQAGLIQDTVKEDRPFNPTIIHQGFQDSSDCCFSYASQIPCSRFIYYFPTSGGCTKPGIIFVTRKRKRVCANPSDQRVQTCISTLKLGPRSGNSAIA", "length": 115 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6EKJ0-1", "protein_name": "General transcription factor II-I repeat domain-containing protein 2B", "gene_name": "GTF2IRD2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQVAVSTLPVEEESSSETRMVVTFLVSALESMCKELAKSKAEVACIAVYETDVFVVGTERGCAFVNARTDFQKDFAKYCVAEGLCEVKPPCPVNGMQVHSGETEILRKAVEDYFCFCYGKALGTTVMVPVPYEKMLRDQSAVVVQGLPEGVAFQHPENYDLATLKWILENKAGISFIINRPFLGPESQLGGPGMVTDAERSIVSPSESCGPINVKTEPMEDSGISLKAEAVSVKKESEDPNYYQYNMQGSHPSSTSNEVIEMELPMEDSTPLVPSEEPNEDPEAEVKIEGNTNSSSVTNSAAGVEDLNIVQVTVPDNEKERLSSIEKIKQLREQVNDLFSRKFGEAIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILEAAEFIKFTVIRPLPGLELSNVGKRKIDQEGRVFQEKWERAYFFVEVQNIPTCLICKQSMSVSKEYNLRRHYQTNHSKHYDQYTERMRDEKLHELKKGLRKYLLGSSDTECPEQKQVFANPSPTQKSPVQPVEDLAGNLWEKLREKIRSFVAYSIAIDEITDINNTTQLAIFIRGVDENFDVSEELLDTVPMTGTKSGNEIFLRVEKSLKKFCINWSRLVSVASTGTPAMVDANNGLVTKLKSRVATFCKGAELKSICCIIHPESLCAQKLKMDHVMDVVVKSVNWICSRGLNHSEFTTLLYELDSQYGSLLYYTEIKWLSRGLVLKRFFESLEEIDSFMSSRGKPLPQLSSIDWIRDLAFLVDMTMHLNALNISLQGHSQIVTQMYDLIRAFLAKLCLWETHLTRNNLAHFPTLKLVSRNESDGLNYIPKIAELKTEFQKRLSDFKLYESELTLFSSPFSTKIDSVHEELQMEVIDLQCNTVLKTKYDKVGIPEFYKYLWGSYPKYKHHCAKILSMFGSTYICEQLFSIMKLSKTKYCSQLKDSQWDSVLHIAT", "length": 949 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6NXT2-1", "protein_name": "Histone H3.3C", "gene_name": "H3-5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARTKQTARKSTGGKAPRKQLATKAARKSTPSTCGVKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFNTDLRFQSAAVGALQEASEAYLVGLLEDTNLCAIHAKRVTIMPKDIQLARRIRGERA", "length": 135 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6P3W6-1", "protein_name": "NBPF family member NBPF10", "gene_name": "NBPF10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVVSAGPWSSEKAEMNILEINETLRPQLAEKKQQFRSLKEKCFLTQLAGFLANRQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHSQERELTQLREKLREGRDASRSLYEHLQALLTPDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEAEKVLESSAPREVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTLVVDRESSHDECQDALNILPVPGPTSSATNVSMVVSAGPLSSEKAEMNILEINEKLRPQLAEKKQQFRNLKEKCFLTQLSGFLANQQKKYKYEECKDLIKFMLRNERQFKEEKLAEQLKQAEELRQYKVLVHAQERELTQLKEKLREGRDASRSLNEHLQALLTPYEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDNDDDEDVQVEVAEKVQKSSAPREMQKAEEKEVPEDSLEECAITYSNSHGSYDSNQPHRKTKITFEEDKVDSTLIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNLQESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVCMAVDIGRHRWDQVKKEDQEATGPRLSRELLDEKGPEVLQDSQDRCYSTPSGCLELTDSCQPYRSAFYILEQQRVGLAIDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAFDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEENHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLEEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLEEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQRVGFAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDEEEEEDQDPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGYLELTDSCQPYRSAFYVLEQQHVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDRIKKDQEEEEDQGPPCPRLSRELLEVVEPEVLQDSLDRCYSTPSSCLEQPDSCQPYGSSFYALEEKHVGFSLDVGEIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLSRELLDEKGPEVLQDSLDRCYSTPSGCLELCDSCQPYRSAFYVLEQQRVGLAVDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYSTPSGYLELPDLGQPYSSAVYSLEEQYLGLALDVDKIEKKGKGKKRRGRRSKKERRRGRKEGEEDQNPPCPRLNGVLMEVEEREVLQDSLDRCYSTPSMYFELPDSFQHYRSVFYSFEEQHISFALYVDNRFFTLTVTSLHLVFQMGVIFPQ", "length": 3795 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6UGQ3-1", "protein_name": "Secretoglobin family 2B member 2", "gene_name": "Scgb2b2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGTLLLLALLVTGELGFQRTEACIPFFGVYLGILSGNRIGLHTELAPFDPTVEEKEAFEKIQDCYEEEGLKAKTEDMKLMTTILFSSECRSYYTKEVLKNILVKFSKKLTHGS", "length": 114 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6YCH2-1", "protein_name": "TD and POZ domain-containing protein 4", "gene_name": "Tdpoz4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGELEAKSRGDTQSHEQKLCYRWTISNFSFFVEETEEYITSLVFSLEDNDKMTWCLRVYPTGVDEKNKDYVSLYLILLSCEKGSVWAKFEVCILNAKGEKCNTERIPSFSRIQPHQPFGFEKFITRDSFLSPAQVLTPDDKFTLLCKVSVLQDSFSISGQNPRPAIKVTRCTLENDVGELWENPLFTDCSLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLTNCVEIHDLDPQVFKEMMGFIYTGKVPHLHSHSMACDLLAAADRYGLEDLMVMCEDALCRSLSVENAAHTLIVADLHSTEHLKTQALDFIIVYASEVSKTSGWMSMVESHPRLVAEAFHSLASAQRVFWALPFKQLKWSLRPTQL", "length": 370 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ZMA2-1", "protein_name": "Olfactory receptor", "gene_name": "Or1o1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNCTQSPGFILLGLSSDPEKWQLFFSIFLALYLLGFLGNLLLLLAIGADVHLHTPMYFFLSQLSLVDLCFITTTAPKMLEALWTGDGSISFSGCLTQMCLFGVFADMDNLLLAVMAIDRYAAICQPLLYPLLMTPCRCGVLACGSWGIAHCASLVYTLLLSQLSFHSNQEIPHFFCDSRPLLWLSCSDTHLNEFLMMVLSALLGISALLCIVSSYGCIFCAVARVPSAKGRRKALATCSSHLSVVLLFYSTVFATYLKPPSTSHSSGEVVAAVMYTLITPTLNPFIYSLRNKDVKNSLKKLLNMEKPLD", "length": 309 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q70YC5-1", "protein_name": "Protein ZNF365", "gene_name": "ZNF365", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQQKAFEESRYPWQESFENVAVCLPLRCPRCGDHTRFRSLSSLRAHLEFSHSYEERTLLTKCSLFPSLKDTDLVTSSELLKPGKLQSSGNVVKQKPSYVNLYSISHEHSKDRKPFEVVAERPVSYVQTYTAMDLHADSLDGTRSGPGLPTSDTKASFEAHVREKFNRMVEAVDRTIEKRIDKLTKELAQKTAELLEVRAAFVQLTQKKQEVQRRERALNRQVDVAVEMIAVLRQRLTESEEELLRKEEEVVTFNHFLEAAAEKEVQGKARLQDFIENLLQRVELAEKQLEYYQSQQASGFVRDLSGHVLTDISSNRKPKCLSRGHPHSVCNHPDLKAHFHPKGRNHLKKAKDDRASMQPAKAIHEQAESSRDLCRPPKKGELLGFGRKGNIRPKMAKKKPTAIVNII", "length": 407 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q71LE2-1", "protein_name": "Histone H3.3", "gene_name": "H3-3A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA", "length": 136 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q7KR10-1", "protein_name": "Probable cytochrome P450 12d1 distal, mitochondrial", "gene_name": "Cyp12d1-d", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNTLSSARSVAIYVGPVRSSRSASVLAHEQAKSSITEEHKTYDEIPRPNKFKFMRAFMPGGEFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERIKEIRDPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMKRTLNDSLNVSQKMLKENQDALEKRRQAGEKINSNSMLERLMEIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNGFGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNRDASRPFKTMFLMEPAITFPFKFTDIEQ", "length": 521 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q7M715-1", "protein_name": "Taste receptor type 2 member 117", "gene_name": "Tas2r117", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKHFWKILSVISQSTLSVILIVELVIGIIGNGFMVLVHCMDWVKKKKMSLVNQILTALSISRIFQLCLLFISLVINFSYTDLTTSSRMIQVMYNAWILANHFSIWIATCLTVLYFLKIANFSNSFFLYLKWRVEKVVSVTLLVSLLLLILNILLTNLETDMWTNEYQRNISCSFSSHYYAKCHRQVLRLHIIFLSVPVVLSLSTFLLLIFSLWTHHKRMQQHVQGGRDARTTAHFKALQTVIAFFLLYSIFILSVLIQIWKYELLKKNLFVVFCEVVYIAFPTFHSYILIVGDMKLRQACLPLCIIAAEIQTTLCRNFRSLKYFRLCCIF", "length": 330 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7M719-1", "protein_name": "Taste receptor type 2", "gene_name": "Tas2r115", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCAVLRSILTIIFILEFFIGNLGNGFIALVQCMDLRKRRTFPSADHFLTALAISRLALIWVLFLDSFLFIQSPLLMTRNTLRLIQTAWNISNHFSIWFATSLSIFYLFKIAIFSNYLFFYLKRRVKRVVLVILLLSMILLFFNIFLEIKHIDVWIYGTKRNITNGLSSNSFSEFSRLILIPSLMFTLVPFGVSLIAFLLLIFSLMKHVRKMQYYTKGCKDVRTMAHTTALQTVVAFLLLYTTFFLSLVVEVSTLEMDESLMLLFAKVTIMIFPSIHSCIFILKHNKLRQDLLSVLKWLQYWCKREKTLDS", "length": 310 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7RTZ2-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 17-like protein 1", "gene_name": "USP17L1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSSETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTLPLANYMLSREHSQTCQRPKCCMLCTMQAHITWALHSPGHVIQPSQALAAGFHRGKQEDVHEFLMFTVDAMKKACLPGHKQVDHHCKDTTLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVKQALEQLVKPEELNGENAYHCGLCLQRAPASNTLTLHTSAKVLILVLKRFSDVAGNKLAKNVQYPECLDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHDGHYFSYVKAQEVQWYKMDDAEVTVCSIISVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRAKQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVGKVEGTLPPNALVIHQSKYKCGMKNHHPEQQSSLLNLSSTTRTDQESMNTGTLASLQGRTRRAKGKNKHSKRALLVCQ", "length": 530 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TMR7-1", "protein_name": "Monocarboxylate transporter 7", "gene_name": "Slc16a6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTQKNSKLCSRANVYTQVPDGGWGWVVAASFFFIEVFTYGVIKSFGVFFNDLMDSFDESNSKISWIISICVFIMTFTAPLSTILTNRFGHRLVVMGGGLLISVGMIAASFSQRVYQMYISIGIVSGLGYCFSFLPTVTILSQYFDKRRSMVTAVASTGECFAMFAFAPAITALKEHIGWRYSLLFVGLLQLNVMVCGALLRPIIIKGPGSPKAIPLEPRREVQYMLENEKTRTSIDSIDSGVELTTSPKNVPSEAKREQEVRVEQQQTLVVGPKHSQKRAPLLDFSILKDRSFICYTLFGLFATLGFFAPSLYIIPLGISLGIHPDRAAFLLSTMAIAEVFGRIGMGLVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPLLAEDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVRPCKKGLCQNPHSGENQTDGHRGKALQDIPEDFLEMDLGKCEPRAHMKMDPV", "length": 522 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TN50-1", "protein_name": "Mas-related G protein-coupled receptor member B8", "gene_name": "Mrgprb8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSSIPDPEADLIQLNGSYHTETSPCVIESRVMILLSIIIAFFGLAGNAMVLWLLAFRMRRNVFSVYILNLAGANFLFLCTHTAFSLEKIIVLFHSVHIHIPLLFYTLSTLAYLAGVSMVTAISAEYWLSGIWPYWYQGQRLKHTTTVICTGLWGLALLLSLLEGKSCGFLGSTYNQDVCWKLDFIIVAWLLVLFAVLSRSIQVLLVRIFCGSQRTPVTKLHVTIVLTALVLVICGFPFGIIFYLLYWTTEVYYIMPCNSFHETILLLSYINSCANPIICLLVGSIRHCRFQCGTLRLLLHRAMQDIPEEEGEELEEVVGERVQNSIP", "length": 328 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TPX8-1", "protein_name": "Oogenesin-2", "gene_name": "Oog2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNFYSPPTLMELARQCLLRDEYLAISALKDLPNMMFPVMFKEAFIDGHTKILTAMIPVWPFPYLSVGTMLKNLNLDTLKAVLEEIDILISKPVFSSRCKLREITLSHDLVVVWAGSHEVEGLPEFMEQEKPVENSPGYGTKNKLKVTTELQFMEGHLDECSTYLLQWAYQREDSIHLHCRKLKIYGLTKAAVIEMFKIVHAEYIEDLELSCLCLEYLDFLNPYLKQMSNLLSLTLDEIIYTLNIDDYRNLNEEKVITVISHLPTFHHLQELYVHGVIFIECLRCLKKPLEVLSFTDCDLSQSDLDYLPYCLNIFELRSLHLTDVRLSNLLLEPLGFLLERVRHTLKSLQLMSCEMGETHFNALLPALSQCYQLTVVNFYGNELSLLFLKKLLHHTAKLSQLADELYPAPQECYDNRDVVLSHRLENFCSELLDILRAIREPKKVTFGTIKCSKCGGSYVYDLETQCCFFEKNPPWA", "length": 476 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7TQY5-1", "protein_name": "Olfactory receptor", "gene_name": "Or4k38", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEDSNRTVSSEFIFQGLCSSRQLEIFLLLPFSILYLMAVVGNLFVVILIIIDHHLHSPMYFLLANLSFIDFCLSSVTTPKLTIDLLKENKTISFVGYMRQIVCVHFFAGGEMVLLVTMAYDRYVAICRPLHYSSIMDRQKCIWLVVISWIVGFVHAISQMLLILDLPFCGPRVIDSFFCDIPLVMKLACMNTDTLEILINADSGILATTCFILLLISYTYILLTVQHRSKDGSSKALSTCTSHIIVVLLFFGPIIFIYLWPVSITWVDKFLAVFYSVITPLLNPAIYTLRNKDIKNAIKKLISHK", "length": 305 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7TR72-1", "protein_name": "Olfactory receptor", "gene_name": "Or8k25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKYNLTIVTEFILVGITNHHEFQVPLFGLYLIIYLTSLVDNLGMIILTIVDSRLQTPMYFFLRHLATTDLGYSTAVGPKMLRNFLVDQNIISFYACAIQSSFFGMFIVCEFFILSAMSYDRYVAICKPLLYTVIMSQKACWILVTIPYLYSIIVSLLVNIKIFTLSFCGYNVISHFYCDALPLLTLACSNTHEIEAIILIFSAFNLLSSLLIVIGSYLLILMAILRINSAEGKWKAFSTCGSHLTVVIVFYGTLIFMYLQPTFTHSIDTGKVISIFYTQVIPMLNPLTYSLRNKDVKDVLKKPMEKVHNLFS", "length": 313 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7TSF0-1", "protein_name": "Desmoglein-1-gamma", "gene_name": "Dsg1c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDWHSFRIAALLLTSLVVLEVNSEFQIQVRDHNAKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQPVTYRISGVGIDQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLENPLELRVRVMDINDNPPVFSMTTFLGQIEENSNANTLVMKLNATDADEPNNLNSMIAFKIIRQEPSDSPMFTINRKTGEIRTMNNFLDREQYSQYSLVVRGSDRDGGADGMSAESECSITILDVNDNIPYLEQSSYDITIEENTLHSQLLQIRVIDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLKVVKPLDYEAVKNLQLCIGVRNVAEFHQSIISQYRLTVTLITVTVLNVVKGCVFQPGSKTFIVDSRMEANHTVGEFLATDCETGQATNKFKNVRYRYVMGNNPENLLVVDSGIITLRNRVTMEQYERLNKRYEGTVLSIHDSLQRTCTGTIIMVLCGFWTTTEHPTTSTEKPVTLSITPNVDNVHFGPAGIGLLIMGFLVLGLVPFLLISCDCGGAPGGGAGFEPVPECSDGAIHTWAVEGPQPGGITTICVPQMPPGNANVIEYIDNSGVYTNEYCGREMQDLGGGERTTGFELMDGVKTSAAPEICQEYSGTLRRNSMRECRDGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIEDLDESFLDTLGPKFKKLADISLGKEIDSYPDPDPSWPPQSTEPICPQHMEQLASGHPSISPHFGKTTVISENAYPSGPGVQHPMLIPDPLGYGNITVRESYTTSGTLKPSVHFHDNQQASNVVVTERVVGPISGADLHGMLEIPALRDGTNVIVTERVIAPGSSLPNSLTIPNPRETSNVVVTERVIQPTSGMIGNLSIPP", "length": 911 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q803M0-1", "protein_name": "Protein phosphatase 1 regulatory subunit 3B", "gene_name": "ppp1r3b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPIELAMSLYLSSDEFLNPRASKYSRPLQPCLNQCKSSKLSFSSLKEQSEFNGVSRALMIPGRAKKHVSFADHKGLALTVVKIFSEFDDPIDIPDNIDNFFTSSLTVSEGKDKLTLDFDQPSADYLKFRQRIENDHVCLEHCMLKEKSIMGTVKVKNISFEKSVKLRITFNTWKNHTDVECQYVKDTYTGSNRDTFSFEASLPEQVPSHERIEFAICYEVNGDTLWDNNQGKNYRIIQSALRKSSNESNGGHQQYSQSDWDIHFDRYGSPRCSRGIFPHWPSYVGYEDIGPYY", "length": 293 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q80SW5-1", "protein_name": "Embryonic testis differentiation protein", "gene_name": "Etd", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDEKNPEAVPRPPEQNTELVPPKKSKSKKPANILIYLIDRHLGRPRNDMDLFEWVWTLK", "length": 59 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q80VJ6-1", "protein_name": "Zinc finger and SCAN domain containing protein 4C", "gene_name": "Zscan4c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASQQAPAKDLQTNNLEFTPTDSSGVQWAEDISNSPSAQLNFSPSNNGCWATQELQSLWKMFNSWLQPEKQTKEQMISQLVLEQFLLTGHCKDKYALTEKWKASGSDMRRFMESLTDECLKPPVMVHVSMQGQEALFSENMPLKEVIKLLKQQQSATRPTPDNEQMPVDTTQDRLLATGQENSENECNNSCNATEANVGESCSGNEMDSLLIIQKEQHPEHEEGNVVCQFPHGARRASQGTPSHHVDFPSAPTTADVPMEEQPKDLSRENISEDKNNCYNTSRNAATQVYSGDNIPRNKSDSLFINKRIYHPEPEVGDIPYGVPQDSTRASQGTSTCLQESLGECFSENDPREVPGLQSRQEQPISDPVLLGKNHEANLPCESHQKRFCRDAKLYKCEECSRMFKHARSLSSHQRTHLNKKSELLCVTCQKMFKRVSDRRTHEIIHMPEKPFKCSTCEKSFSHKTNLKSHEMIHTGEMPYVCSLCSRRFRQSSTYHRHLRNYHRSD", "length": 506 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q80VT8-1", "protein_name": "S100 calcium-binding protein, ventral prostate", "gene_name": "S100vp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQNLTSTEQEIMELLMILQEFSVKKIDKLDVQEVKRLFREELPNFLKAMDEATKNKILNDKGKEMPFDEIWDMIGRMALEYRKKNSNALKD", "length": 92 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80XZ1-1", "protein_name": "Polypyrimidine tract-binding protein", "gene_name": "Smptb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRNSPPAAEGNGSKRFKGDSWGTRDPSRLVHILRLPSCVTEGEILCLALPFGEVSNLLFLRAKNQAFVEMSTEESANTMINYYTWMPPVLRGQPVHIQFAHYRELKVSSSPSQEISLSQAGDSREATASSLVAVPGQAAASGQTAVPSQLGAQPCLPPEDSYQAGTVALAPPASAVDTELVVAWQSPVLRILVENYFYRVTLEVLHQIFSRFGTVLKIITCTKNNRFQALLQYAHVMSAERAKLFLDGQNIYDACCTLRISFSGLTNLMVKYNNDKSRDYMRPDLPSDDSQPSPVQVQNMASALPAPAMSSASPYASIALPHTFAIPQAAGLANPEVFKTLHPQAIQEVAMASSSSSSSTAAAAVGAAEIAAAAVPGAEGSMVTSGSPGVGSPVLLVANLNQEKVTPRSLFILFGAYGDVHRVKILFNRKENALVQMADGSQAELALRHLNGHKLYGKALCILLSKHQSVKLPREGKEDQGLTKDYANSPLHRFKKPGSKNFQNIFPPSATLHLSNLPSLVSEEELKNLFSSNGYAVKAFRFFPKNHKMALIRMGSTEEAIQALVDLHGHLLGQNHHMRVSFSRMTI", "length": 588 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q810J1-1", "protein_name": "Pregnancy-specific glycoprotein 22", "gene_name": "Psg22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVSSELLSNGWTSWQRVLLTASLLTCWLLPITAGVTIESVPPKLVEGENVLLRVDNLPENLRVFVWYRGVTDMSLGIALYSLDYSTSVTGPKHSGRETLYRNGSLWIQNVTREDTGYYTLQTISKNGKVVSNTSIFLQVNSSLFICGRPSPPALLTIESVPASVAEGGSVLLLVHSLPDNLQSLLWYKGLTVFNKVEIARHRTVKNSSEMGPAYSGREIVYSNGSLLLQNVTWEDTGFYTLQIVNRYWKMELAHIYLQVDTSLSSCCDDFNSVQLRINPVPPHAAEGERVLLQVHNLPEDVQTFLWYKGVYSTQSFKITEYSIVTESLINGYAHSGREILFINGSLLLQDVTEKDSGFYTLVTIDSNVKVETAHVQVNVNKLVTQPVMRVTDSTVRIQGSVVFTCFSDNTGVSIRWLFNNQNLQLTERMTLSPSKCQLRIHTVRKEDAGEYQCEAFNPVSSKTSLPVRLTVMNE", "length": 475 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q863C3-1", "protein_name": "Gastrin-releasing peptide", "gene_name": "GRP", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MRGREVPLVLLALVLCLAPRGWAAPVTAGRGGALAKMYTRGNHWAVGHLMGKKSVAESPQLHEEESLKEQLREYAQWEEATRNLLSLLQAKGARGHQMPPWEPLSIHQPAWDSEDVSNFKDTGPQHEGRNPQLN", "length": 134 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q869X2-1", "protein_name": "Probable polyketide synthase 17", "gene_name": "pks17", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTFNNIKDENNDDIAIIGMGFRFPGGGNNPYQFWNQLSNKMDGISKIPTEKWSRSFYEQKYINNEYGGVLKDEEWKNFDPLFFGISPKEAPIIDPQQRLLMTTLWEAFEDANIKPSTFRGSDTAVFIGMMNTDYQRCQFRDISYVNPYITPGTAGSFISNRLSFSFDLRGPSMTLDTACSSSLNAVYLGCQAIANGDSKMAIVGGVNGIFDPCFSMTFSGLNMLGHKGQCRSFDAGADGYIRSEGGGVCILKKYSDAIKDGDRIYCVIKGGSSNVDGYNAKTNIIQPSMKAQGENIEIALKKSGVNPSDIYYIEAHGTGTPVGDPIEIEAISRIFKDNHTPDAPLYIGSVKSNIGHLESAAGIASLIKVALSLKNRSLVPNIHFEKPNPLIKFEDWNIRVVTDEIQFPINKLINMGINCFGLSGSNCHMILSEAPINYDELLKTTNNNSTSSSSNDDKKEYLIPFSANCNISLDKYIEKLISNQSIYKDTILFKDFVKHQTISKSNLIKRKVITASDWDDFLNKRNETTSTSSLTSTISAPASSTPVIYVFTGQGPQWRDMGKALYETESVFKDAIDHCDKLLANYFGYSILQKLLSLESEDSPEIHHPILAQPSIFLIQVGLVALYKSFGISPSIVVGHSFGEIPSALFSDVISLETAVKIVYYRGLAQNLTMGTGRLLSIGIGADAYLEKCALLYPEIEIACYNDPNSIVITGSEQDLLGAKSTLSAEGVFCAFLGTPCSFHSSKQEMIKEKIFKDLSDLPESNVPCVPFFSTITGSQLSHKGFYNVQYIYDNLRMPVEFTKAISNIFNFIEENESYKNAIFLEIGPHPTLGFYIPKCKPSNSTITSKPIIVSPLHKKKEELTQFKLAISTLYCNGVEIDFASGQQLLPTSSSSGGGDISSFKESTNKLPRYQWDFEEYWDEPNQSKMVKRGPSNNLLGHDQFAGNTLMELFIDIDKSAHQYLKGHKIKGKYLFPGSGYIDNILRQFNGQDITIFNLEFSNPFFLKDGVQHHLQTSITPTTKGEFKVEFFIKDNRNSTKWTKTSNGRIGLFKHNPKNNKLDIEKLKSQCSFTTLTKSEVYNKLLLLSLPYGPTFQRVESCSIGDGCSFFKLSMSPCSEFDKDFLNPSIIDCAFHGLLVLSEGPQEIVFDRLQDMKFYSSNVPSTRPQFIYAFAKFDKIEGNSTHGSLNIILEDGTLLISIKNVKCTSLIRLKKQSIKYPSQNVYSHHWQSKDSPLTLIENQLIEEKSSESKINFEKLLNDKLFNYYLIRLLNQSIKSEFIEFDYKTSTVDTLDIGSKNAKLLEKIQSILNPIDSLDQSIDITSLKQAIIVKSSFKNEIKLVEKSIKRIVSLLKGGESEHFSPSNPSSPNDTPRNNSNNCSSKNNAASSDDADDDTNNEETINQLNNEPFNFSNSQFISNQNQLISKTIVNSFDRLINSIEIGEKKLIKIIDLSSIYQNYQLSKLLLLQLNQLLINLSNNNNIEIEYTIPSNTKNIDSITEETKSISNVLNIKYRSFDLQDDLESNGYLNSNYDLIITSLLLVSTNSIDSNEVLSKLYKLLLPKGQLILMEPPKGVLSFNLLFANDFKQSLEIKSEQEIKSLIIYCGFTKIETNLNTKDDEEQQQPPPPSILIVQAEKRDIESMSLTFSSDPKSLNSSYSNCIFIVSKEQKENPTSYIQEYFDITEFFCQNATIIEADDSELLTKTIESGVGKNDIIFFLVSLEELTIENYKQVTMQYTLVNQILLRNNLSTRFALLTYDSQNGGKNYLGSSLIGTFRYFLEFRSLNIFSIDVDKDSIDNLTLFLRLVDLSTIGDRETIVRNNKIFVQKIFKEPKLLSPSNNYEKNTNNLFLYSNSNLDFSFQSKEKLLHGCVEIKVMSTGINYKDSLFYRGLLPQEVFSKGDIYSPPFGLECAGYITRVAPSGVTRFKVGDQVVGFASHSLSSHVTTHQNKIVLKPENISFNEAAAVCVVYATSYYSIFHIGAFIADKESILVHSATGGVGLASLNLLKWKRNQLKKHGNSEISNDASIYATVGSKEKIDYLQEKYGDLITAIYNSRDTEYCDEIKQQSAQGGVDLILNTLSGDYLSSNFRSLSQVGRIMDLSVTQLVENDSLDFSNFKYHVGYNTIDLDRATKYNSKIIRDILTEVFDAISDGSLENIPVKVFPAIQVKTAIEYINERVHIGKIVVDFENFEQDILKPALQEKENPIQLNKVKKLEHTCDTLNNTILITGQTGIAVHILKWIISGSVLNSNKSQQQVTDFIILSRSSLKWELENLINQTKHKYGDRFRFHYKSVNIADLNSTRTAIDQVYSSCKNVSPIKSVLHFATVYEYILPENITQTVIDNTHNPKAVGAINLHNLSIEKDWKLENFILFSSIGAIIGGSKQCAYSSANLVLDSLSNYRKSIGLASTSINWGGLDAGGVAATDKSVASFLEGQGILLVSLSKILGCLDSVFQPSNSHLSNFMLSSFNIDNLLSSAPQMKRKMDHHLTNYKTSSASSDDSLGDSGSTQAKVISTISELLSIHPSKLNLDTRLKDYGIDSLLTVQLKNWIDKEFTKNLFTHLQLSSSSINSIIQRISSKSTSTSTPNPTNTSKQTATKKT", "length": 2604 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q869Z5-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSHLTPKPNVLNVYGAGTPNFVKVQILLEEKNIPHVYHKIDFSKNEQFDPEFLKFSPNNKIPAIVDNTVEPNGISVFESAAILMYLSEKHQFTDLYADFKTDPALHAKHLEFLFFQMSGVGPMTGQLGWFLRQPEPKNTQAIERYSEEVKRLYRVLDKILSTNTWVAGEQYSIADISLLGWALYFLKGYYDDHITREQFPNVYRWLDLAAKRPAIIKVLETIQPKQK", "length": 227 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86AE3-1", "protein_name": "Probable polyketide synthase 9/36", "gene_name": "pks9", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGNLKNINLKEKGVAIVGIGFRIPSGNNENSISSPDDLFNNLKNGFDGVSSTSERWSDNFHKLGEISSPNAGLLPFKEWKSFDPLFFGINPSEAPLIDPQQRLLLKCTWEALEDASIDPISIRGTNTSVFIGSSTIDYLHTNKHQDSVLKNAIAQSTSAISNRISYCFDFNGPSLSIDTACSSSLNAVSQGYHSILNGTSNMSIVGGVNLILDVDIIKAYSILSMLSKTHGKCKTFDESGDGFTRGECVGVVVLKNLQDAVKDGNRIYCVINGSSSNVDGNGNMDKVNFYSPSKQSQFNNINSAFKSTNDKLSINDIQYIEAHGTGTKTGDPIETEAISMAFKNRDKSTPILIGSIKSNIGHCEAGSGVASLIKCCLMFKYQCFLPNIHFKNPNPLIKFNEWNLKVVTSPIPFNKRNNEKPVSMMINNFGVTGSNCCLLISEFKNNNNFKENINLESQSVNDRVLIPFSANSSNSLNQYQSKFKNIINNQFNFIDFTANQIYSKSNFLYQRSVVIASNSNELFENISNKKQIQTKNSIISNMSFKGKNPITIFVFSGQGSQYPKMALELYNNEVIFKKSIDLIDSKLSKYYGFSVWEKVKTIKDDDLTSIHDPIFAQPALCMISVSLFELYYHWGVNPSFILGHSLGEISASYCSGMIDLDTFCYTVYQRSIAQSKTNGCGRMLSINISDEEFKSMYSQKYPQIEIACYNSPQSIVVAGNESILNEISKELKEKEIFTTMLGSLSSFHTSSQQCTKDSILQLNIESNQPKVPIFSTVTTNLFNESNRFNSQYVYDNIIKPVKFTQTISNIYKHIESNQLNNEIVFIEIAPHPTLLFYIKQMVPSSLNESVSVYSALHKKKNDVEEFQQTISNLYCQNGYNINFKCQFNNKKSNQSINLPLYQWDEELYFTQAQTLEQHRKEGPPIDHLGTSNSYNSPFNNSYRTSIDIKNKPFLYLKGHMVKGKYYFPGCGYIDNIIQLYKNQDIFISFIEFKTPLILIEGINQYLQTNIQQTGKSEYRAQFHFKDQKSNEWIQSSNANFQLLDHGNDIPPKYNIKEIIENKCNLSKLTKNELYTHIKSKTGLNYTGVFQGVTECYIGGDCTLSVVSLESQTNSFLNIPILDTCLHGMIGLSNDQCQIVFDKAIGFKYYSSNIPANLKDYKDSVYVYSHLKSKSVDSFFGSIIVMLSDGSVLYEIEEVVCKSLIPIKDSLKIEYPNDELYKVHLQSKDSPIPTPSSFKSIIYENDFFHSALNIPEDLFKYISTLFYKDIIKRCPEININKINSHSVNEIISSFSKISKHERLFRFVFETIKENGILNSLEENDDAYFEFNEVIIKSSRIISKLLFPLESDNDNEDLPQSLFQNGLMDKIYKCRYLRKKNQMISHVIKHSIKEIINNNIIIRILEFGGGTASLSVEVIEEIIALLQENPNYQVEIEYTWSDISPAFIADAKNKINKIINDAAITNGFNVIYRPLKIDESLIETQSINPSYYDFVIMSNVLHVVKNIKQAVEQMYQLLTPNGQLLFLEPPYKSVLNDSIVGSFEQWWSFTDTDIRKDRCSMSQQSWCQLLKTCNFKDIAMSKECIFVGIVIHAQKPPISLLNSQPKRDNIIIYGGGNPIFVENIKLYSNSKSLIQIETIQEFNQLLSQSTITNDSIIYFIKTLETLSLDNFKQITLEYIEINRKLLQINSLCKHVLIVSDSRKTNYLASSVVGAARYFDEFQQLKLNTLDFDYDSTQNYINSNNKDMVQFINILTDSKTNVHKEMIIINNKVYYEIVQKEKNLKLKYNSESFENQNNLMCSLSPNLEYQLQSKQIKLRDNQVEVKTIATGINYKDYLNFSGSNSNGDDNTGLPQFGYEFSGIITRVGNNVKDYKVGDNVFGLSNSCTSSHIVTNYKKIQIKPSNLSHNEASSIPIDYLTSFMSLFNIGSLNIEDNESILIHLGSDGFGLSTFEILKWKGFNSNLFVTVNSYETKRYLQDNYGDFITGIYSNTDKSYVTEINKKLIKLGSKKKGVDLILNTLPSDFMDSNFKLLAKYGRIIDLTSNHLNQSEFLKNINFKYNHGYHNFELSLIQKNKIHKCLYEISNAFENGELKTIPIKEFTNLNIKDAIKYITNNKIEKITVSHDHEIYSDIIYRSLDEKEFSILKSNYQINSNNLGKNILVTGQSGIILEILKWIIKYSNINTIENVIILSRSSLKWELELLINETKLSNNNIKFHFKSVDIGDSEQVDNAINEILNENQQITNIDSIYHFAFQQITCKVQEINMKHLDISHGAKSMGAINLHNQSIKRNWKLINFVMASSAISLIGSTDLCTYVCANALLDSFSKYRESLGLPSTCICLGAIESTGFVSKNESVSVFLDGGGFHPTPINQVLGLLDLQIQNAGKFTNSMLSNFKPSKFKNNQQTSLFLKFDYLMNLKNNSEETKIENTGNKNIDELFIEKVSELFSMDESKINKNLRLIDYGADSLIIVQLKNWIDKEIGINLITIQQLQNNTISTSMKMILNSLMKNNQNIDDNNKDLPSNRIDYWKNEMKFEESIKPISNEIQSRNNSEKIILLTGTTGFLGGFLLFNMVRLDSCKLIYCLIRNKSKSNNPLDEIINNLKYHQLYEKLNQSQISKIIPIIGDLSMNKLGLSNDDYETISKNVNLIINPGADINQKSSYQDCKLVNVNGVKEIIKLSLSSLKQRIPIVNFSSFSVFFNQSLDKNFDESVLPSIDNIDNLPTEYMKSKVVGEYILLEASKKYNIPSILIRPPSIFLNPETGIGHISDFSLLSIQSCYELGYYPNQFENDFILINTITWLSNNITNIIMNDNCWTDSKMNIYNVHGKQIQSSLIIKPLEKHFNCKHINTNDWIDMVNNSNKKSCIKLKSFHSLDIILKSENNRYKPNENQSISLSTKSLLESMGSYNTDLEITDKMIISHINQIFNLNETI", "length": 2931 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86AF8-1", "protein_name": "Uncharacterized protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFSKFSIKENKPKKVKSNSSKGFNNNEINSTNNNNNNNNNNNNNNNDSDNFINNNDSNNNNNFNNNNNNNSNNINNKTEDSNDISLLINQFIGSSPAPSTCSGSDKFSIKPKKIVTPSKRKNSTSGSDIIDFNNCNNNNNSKSNSDSNNNKYNNSNSNNNSCNNTNNGNERKMKGYDYGNNNSNNNYSSSSRDYNSNNNSSPRDYNNNNNNNNNNNNNNNNNSNNNSPRDYNNSRDYNNNNTNNNSSPRDSNSNNNRNSSSRDFSNNNSSPRDYNNSRNSNNSFLNNNNNNNNNSNNSNDNSPRDYNYSSSNSSPRDYNNNNDTFSKKRNNVGNSILEIKSNPTSPRIKPIMVWPRSSPRIVNKLPPVQSLVDLTEIEMIDDNNNNNNNNNNNNNNNNNNNNNNNSNNNNNKSGSNNNFSDSDSDKDNYNNNNNTNNNSFNSDSDNYNNSNNNNSNSNSNSNSNSNSNSNNNNNNNNNSNNNNNNNNNNNSNNSNKSNNNFSNIKILEKRRKSINEISDNLTTRNIEEIDSKMAHEFEHPFLEKLIFAGQRPPFVECDDYFLKRYKNQFQYYLDISMKSIINTRDIGEGDDDDEINSVPFKCTLCSYEYDEENNNENTNGFIDEADKIYNRSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNSNNNNNNNFYDKKYFKNNYFQHLLSKHLNQIKAKGIQDTNVYNDEANIPLGSKKCDHLECSEIILKNEFTKHIKKLHHHHKDEDIDICPRCKILKKSIQKRIVKFSKKKQEKDDDNNSKPVSNKVATISHNPSPNNIDKDINNNNNNKNNKNNTNNLENDNNDNSSNNNYLENEEEPEIVFQDIKPNNNNNNNNNNNNNDDNNNDNNDNNDNENNNDNNNDNENSNNNNNNS", "length": 901 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86BK9-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 22", "gene_name": "Dmel\\CG32971", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSDSKDEALLKSFKTQLKDNVLSMLLNFEELLKLVSPRTPGQITNDTEQELNAFEMQVRAGNFVRAGEALIKLVHDVKEYQIIYDYSNIEEEMDRQSEAMHAKVTEYDQTLIKMVKDLEEELSELEYEYYEKSGGPDLDSKDLLV", "length": 145 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q86IJ5-1", "protein_name": "Uncharacterized protein DDB_G0272718", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPPHGHHHHHHGHHGHHEHITITPVYAPPQVVQPIYAPPPVVQPVYVQPPVVYPQATIVLETGHHHGHHHHHGHHGHHDHHHHGHHGHH", "length": 89 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86IV6-1", "protein_name": "DNA replication ATP-dependent helicase/nuclease DNA2", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNFFEKKNNNNNNSSNNNNNNNNNKNNNNKNLDKNNSSDRNNNNNGDKNNLKPTQKSLIDLWFQVDDEDEEYELSSLSNDGGSSFNSFKVNNRDTSIGSDIYSKTITPSSLALSTSSLISSTLTPPTQSPPFSKKNEKTSSFLNSPSSQKSKSNNSNVKEKLSPQYSSSSQLSDFFKKKKRPLLDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTISSLNTNSNNNSSGSSNGSSSSSSGGGNKSSNNKKQKVSQSTSSTSLKEKQSQQSILSYLNPTPSLPTPIFDKPIERSDSNLATSSFSKLNFDDIPLDDEELSQKINTPSPKLILKNTFSSTPTQKSPSLSSTPPNKIKITDKKLPNSSSSSSSPPPSSAKSKLSHRSQSSPLSPLITNLNQNKSNEFDDINFNFNIPSPLKEINNKPNIKSNSKETLTPLTQIFHSSSPPPSIIIESSPSVCFSPTPTKNQSPTLSNLSPTFSFLSDTSPVKSPSQLFEFTFDDPLSPKLISSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNTFISKNNLINLFNEQSNQENVSTTTTTTTTTTTSTSTNNNNNNRYERVLIINVFYEVTQIFNNSNDKIHKKTLSGFSESIGESREIQLLDEWIYTPVRPGDIVNVIGEFDDNGEIIINNIQNLLILHPDILITGTELGGSLTCTRRSVLKEQIRVGNSNSSTVPIFGSIVHEIFQECLKNNRFHLDDINTFKQEIIGKSTFQLGLSSLGETQDTALNHLENWLPTIDKFAKTFILPSSSSSSASSLKKNLIEINSEKWHLSISKILEIEENIWSLMYGLKGKIDSSLEIKLVKQQQDEKQSKQSKQSKKKKQQTTSPNNNNNNNNNNNNNNNNNNNNNNNNNNGPTTCYLNVPFEIKTGKPYQIPYISHSSQVLIYTLLMNDRYDQDIEMGILYYLKSQEFKSVGLNYGLLHPILFERNQIRSLIVSRNLLAYFLNLNSQPLLKPNPILPEMLRDYHSCTKCYSIDPCVLYHKAIENGDQFTSSLGDLFLEKTNHLSSIHINYLKNWNKIISLEYSIKNNKRKLIWNKSRKFGEKNNSCIGELILISEEYSEITETFSYRFRVNPDKLLNSSISEGDYLLISVEDKYYGMGSGQLSNIINDIITITCREKLSEPPSLLSDYTTPNCNNNDPSYFGNYRNKPLIYIEYEDADQQQQQQQQQQQQQQQQQQQQQQQSQKQQKQKQPNFTQLRGLNNYVNNSKLTPFKWRVDIDEQLSGLSIVKSNLFNLFLKENQKLRSLIVDLEAPIFDKLEQENYWKSIDFQNDYPLLNIDQRNAIIKTLSAKDYSLIHGMPGTGKTTLVISLIHILWRLGKKVLITSFTHTSLDHLLLKFNKQYPNIEMLRVASSLNQIDPSLHRFTLEKQSFGNITQSKQYLERQQLVATSCLGINHQCLLKMQFDYCIIDEASILSQPISMGPILKCKSFVLVGDHHQLPPIVNNKEAGKLGLDISLFKQLSTSHPSSVSNLYHQYRMCNSIMSLSNHLIYNNRLVCGNQSISNLSLQTNYYHNNNNTTHIDLLDHINNWPQIICNPNSSVIFVNTDQLNNSTESSNGDLFYNQTEANIVAILTNCLINKLNINQSQIGIITPIRFQLNFIKKSILKYLSIENNNNNNNNNNNSNNNNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNQNNNQNYLKKIENLDILTIDKFQGKDKDCIIISFVRSNEKKEIGELIKDWKRMNVAFTRAKKKLIFVGSKSSLSKFPFFLDFFEFLDSKNWIYNLNNKIQF", "length": 1838 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86JI5-1", "protein_name": "Probable polyketide synthase 5", "gene_name": "pks5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDMKLNDIENENFINQMKGVAIVGIGFRIPSGNSENSISSPDDLFNNLKNGFDGVSSTSERWSDNYHKLGEISSPNAGLLPLNEWKSFDPLFFGINPSDAHHIDPQQRLLLKCTWEALEDASIDPISIRGTNTSVFIGSSTIDYLHANKHPDLILKNAIGFSPSTLSNRISYCFDIHGPSLSIDTACSSSMNAVTQGYHSILNGTSNMSIVGGVNFVIDVETIKGFSYLNMLSKTHGKCKAFDESGDGFTRGECAGVVVLKKLDDAIRDGNRIYCIINGISSNIDGNGIADKANFYSPSKQSQFNNINLAFKSTNGKISVNDIQYIEAHGTGTKTGDPIETEAISMAFKNRDKSTPILIGSIKSNIGHCEAGSGVVSLIKCCLMFKYQCFLPNIHFKNPNPLIKFNEWNLKVVTSPIPFNRNNEKSVSMMINNFGVTGSNCCLLISEFKKQDYESYENNIGSINKNILVPFSANSPKSLDQYQSKIKNIINNQFNFIDFANNQIYSKSNYLYQRSVVIANNSNDLVNKILNKKHIQTKNPIISNMSFKGKNPITIFVFSGQGSQYPKMALELYNNEVIFKKSIDLIDSKLSKYYGYSVLEKLRSIGDDDTTSIHDPTIAQPAMCMFSVSLFELYKHWGVNPSFILGHSLGEIPTSYCSGMIDLDTFCYTVYQRSIAQTKTHGNGRMLSINISDEEFKSMYSQKYPQIEIACYNSPQSIVVAGNESILNEISKELKEKEIFTAMLGSLSSFHTSSQQCTKDSILQLNIESKKSKVPTFSTVTTNLFNESDPFNSQYVYDNIINPVKFTQTISNIYKHIESNQLDNDIVFIEIAPHPTLSFYIKQMVPSSLNESVSVYSALHKKKNDVEEFQQTISNLYCQNGYNINFKCQFNNKKSNQKINLPLYQWDDELYFAQTQVLEQHRKEGPPIDHLGLSNSYYSPFKNSYRTFIDIKNKPFQYLKGHMVKGKYYFPGCGYIDNIIQLYKNQDIFISFIEFKTPLILIEGINQCLQTNIQQTGKSEYRAQFHFKDQKSNEWIQSSNANFQLLDHTIEMPPKYNIEEIIKNKCTLARLTKNEIYTHIKSKTGLNYTAMFQGATECYIGVDCTLSVVSIESQTNSFLNIPILDSVFHGNISLINDQCQIVFDKVHGLKYYSSNIPNDYKDKSVYVYAKLKSKTSDSYSASFTVLLSDGTVVYEIDEAFSKSLIPIKELLKIEYPNDELFSINLQPKDSPIPAPSTFKSLIYENDRFNAEPPMVENLFQYISTIFYKNIINRCPEINIDIIKSLSIDEIISNFSKISKHERLFKYVFETIKENGILNSLEEKDDTYFVFNEVLIKSSRVISKLLFPLENDNDNEDTPQLLFQNGLMDKVYKCRYLKNKNQMIAHIIKHSIKEIINNNIIIRILEFGGGTASLSVEVIEEIVTLLQENPNYQVEIEYTWSDISPAFIVDTKNKINKIIKGAGITNGLNVIYHPLTIDESLVELQSIKPSYYDFVIMSNVLHVVKDIKQAVEQMYQLLIPNGQLLFVEPPYKSIICDSLFGSFEQWWAFTDTDIRKDHCCLSQDGWYKLLKWSNFESIEMSTESKFMGSVIQAQKPSFTSLINQQPKYDNIIIFGNNCPNFIDNIKPFSNFNEFIQIETIQEFDQLINKSTITNDSIIYFIKSINQLSLDNYKQATLEYIEINQKLLQINSLCKHVLIVNDSRKTNYLASSIVGAARYFDEFQQLKLHTLDFDYDSTQNYLISKNNKMVQFINNLIDSKTNVHKEMIIINNKVYYEIVQKEKNLKLKYNSESFEQQDNLMCSLSPNLEYQLQSKQIKLRDNQVEVKTIATGINNKDYLVYSGLEGSVNSNTPQFGYEFSGIITRVGNNVKDYKVGDNVFGLSNSCTSSNIIVNHERIQIKPSNISHIEAASIPIDYLTSFMSLFNVGCLNIEDNESILIHLGSDSFGLSTFEILKWKGFKSNLFVTVNSDEIKQYLLNNYGDLITAIYSNTDKGYVSQIKNKLIEQGSNDNGVDLILNTLPSDFMDSNFQLLAINGRIIDLSNDHLNQSEYMKNVNFTLNRGYHNFDLMSQRNSRINRSLLTISKAIENGELKLIPIKEFSNSDINDAIEFIIEENRIDKIVVSHDHEVYQELYAKFSNENDFSILKSNYQINSNNLGKNILITGQSGIILEILKWIIKYSNINTIENVIILSRSSLKWELELLINQTKLSNNNIKFHFKSVDVGDSEQVDNAINEILNENQEIINIHSIFHFAFTQIACKVQEINMKHLDISHGAKTMGAINLHNQSIKRNWKLINFVISSSIASLVGSTDQCSYVCANALLDSFSKYRVSLGLPSTSINLGAIESTGFVSKNESISVFLDGSGIIPTPINQVLGLLDLQIQNPGKFTNSMVAKFNPLNFSNNEQINLLLKMDYIFNLHSNGYTKVKESAGSKNVDELFIKKISDLFSIDESKINKDIRLIDYGADSLVIVQLKNWVDQEIGFNLITIQQLQNNTINVSIKIILNFLKKINK", "length": 2512 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86KS1-1", "protein_name": "DNA cross-link repair 1 protein", "gene_name": "dclre1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSDDEDDINLYITRSKNNENKKTNKNRLIDNNIQKTKTTTAVLTTRTTTTTTTTTASTQLKWDYGDEDDDDYSAPKDIDEEQSSKQFNYQNNQIVVKQDHDDYSAPKDMDEEQSSRQFNYQNDQTLVKQDDDHDDYNEPKDIDSQSLIDEDCDFEFDNSDFFFDDGTTNNNDNNNKNNKNNNNNNNNNNNNNNYNNNNNKNYKRKYYQSYNNSNNINNNNNNNNDKFEKRLSDLKKTGKEEAKKRGYQVRKTPTKEKKIPPSFKVIDGTNFLVDGFQYKSEDFTHYFLTHFHSDHYVGITKTWSFGNIYCTEETGKLVSHKLGVDQRYIVKCEWNKLIEIQGVKVAFLDSNHCPGSALILFIIPLRNKDGEIIGEESILHTGDFRYNQSMNNYPLLKGRTISKLYLDNTYCDPQYVFPPQPEIIKQVASIVRKENDGETLFLFGTYVIGKERILLEIAKQEGKPVHVSNEKYAILCCLSTCLDINKFTTNELITPFRAVTMSMLSYHNMLSLLDSSNNKYKRVIGFRPTGWTQAKKSITYLNRGPTTFYSVAYSEHSSFNELRDCIDHFRPTQIIPTVDCDSPIKVKNILAHFSDLYEKKKQLTIASFFSAQPVTNFFQSFFKSKSEPIIDEDNKKLIPITTTTTTNINTLTATDTTTTKIKTSNTLIKDEFTDDLIWDCSDDLISDRKLLTQSDNSSALCKIEKEENFNDLSENNNNSNNNNNNNNNNNNNNNNNNNNNNNNNKLIIENDIKEEIIDFDDPVFISQQKWIEKQIYNNNNNSNNNNFTTPTKTNGNLSNNAKLNLTPTQTQTQTPTQNNKKQKTTNVSPTSYNSNNSSQQSGLKRSKSDPNVKKNQLQTSQPPSQSLITSFFQKCASPTSLFSATPPTPSITTTSNQSTKNKNSTTTTSTSTSNNKPFKN", "length": 920 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q86KX6-1", "protein_name": "TNF receptor-associated factor family protein DDB_G0272348", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEFELEDITIEQSSFTNNNSNNNNNNNNNSNSNNNNNNNNNNINNNNNHNNNNKNNSNNKNEINNQLDIPISNLVVDKENISKKYFCTICSDLLVNSFHADKFKAVQCKNGHYTTCLNCWEKHLEKKKNCIQCGVDVESIESLSSNLLVTQKFTTFKIHCPNSFFDTIDFIKDEVNGCKEIIQINELEEHLKECQYGFISCKNCEEFSKLPFQEFTQCPDFRKNTKEQHDLICPYVKISCEYCGDIINKINKESHNANWCQEITIKCLDCHLPFKKKEINQHQKSFCPETIIQCRYSKGGCNAMIRRSKLSQHLTEGDNHHQFISNILNQQDLKINELELKNTEFCLLLNGQNKKITELEILFKELNDSILIQKQQQKQQQQQQQQQQQQQQQQQQQQQSQQQQSQQQQQSQQQQQSQQSQQNNNSNSHFINNNNNNINNVQMSDSPNGGSLPQAVYKNKWVISNYSEQEQQGISKDYIKSPLFKIGNSTFFLKWFPFGKKKLNYCSIFLYKTQDDKSIIVNYYIHLVNNQISDEVYEKRGCQKYDSENGSAGYGSSQFIKRADLLNDANGFLINDSITIEIEIFATEEILPLQS", "length": 595 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8BI41-1", "protein_name": "Syncytin-B", "gene_name": "Synb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTGFWVLCFVLFPSSLSYPESWMPLVNLTHHILRDTNSSLFSNCWVCLSTQTQRSLAVPAPLSIWTDTPMKLHLTYSVRPFSGSFSISDIERRLRLFRPLTASYSFHNPDRRAIAFLQLVSSTGIFRIITRITSVIYPHKDRFFESAQRPLWGPLFTETVLRSQAPLCISRFFKVSAYATFVGNLSASLCNYTMHISPSTSHENLDLSTTHTFKQAMKRPDAKWKNPLRFSGPPSLIFSKPAYYPCPTDIKHCHTSPATPWMHCPQAPFGTCYNLTLFEPDNSTHPVTMSVNPTHFKVKLQGHRDPYPLSHYQPLTGAALSGQYSVWENEITVQENWDITSNIFSHLLSFSYAFCLNSSGVFFLCGTSTYICLPANWSGVCTLVFQYPDIELLPNNQTVPVPLFASVLSSDSVLRPKRSPHLFPFLAGLGISSALGTGIAGLATSTLYFQQLSKVLSETLEEIAASITTLQNQIDSLAGVVLQNRRALDLITAEKGGTCLFLQEECCFYVNQSGIVRDAARKLQERASELGQHSDSWGQWPDLGRWLPWLTPFLGPLLFLFFLLTFGSCLLNCLTRFVSQRLGSFVQDTAKRHVDSILQNFQYKKLPQDSPDEDTIPT", "length": 618 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8BYG0-1", "protein_name": "Tetratricopeptide repeat protein 24", "gene_name": "Ttc24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSSRQYGLSDVLRALEESRKLADADRSTDQGLLGPFYNDLGMGYFQLQLFPLAVEAFLQALPLCRQPSEQATVLQNLGMTHNVLGNYWEAQEFHQKAASLHGSVGQRWEQGRSFSGLAFSLSQLGDHRAAWDSYLHALQAAQDTGDVKGQWQACEGLGAAAARLGQHDQALKYYKEALALCQHEPSSVRERLVAKLADAMRTFVAQEKIAQARFLPSAPGKLQTSRKAKTSARVQSSAEDAQESQWEGEASEGGHEKKEMEGLVNTATVLGPQRQNRATTHLPSGGPSPSGEEYPFIIAPKKLRVSRSSTWAKEALGRNFQRTRIQSGLCSIM", "length": 334 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8C1N8-1", "protein_name": "Alpha-defensin 22", "gene_name": "Defa22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKKLVLLSALVLLAYQVQTDPIQNTDEETNTEEQPGEEDQAVSVSFGGQEGSALHEKLSRDLICLCRKRRCNRGELFYGTCAGPFLRCCRRRR", "length": 93 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8C1P2-1", "protein_name": "Alpha-defensin 21", "gene_name": "Defa21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTLVLLSALILLAYQVQTDPIQNTDEETNTEEQPGEDDQAVSVSFGGQEGSALHEKLSRDLICLCRNRRCNRGELFYGTCAGPFLRCCRRRR", "length": 93 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8C5Y2-1", "protein_name": "Mitochondrial sheath formation-associated protein", "gene_name": "Misfa", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIVLGWMLFVGLATYMGTFPEAMPPTLKWKERLPGQENKARRRIQALEEELLL", "length": 53 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8CDW1-1", "protein_name": "Protein FAM228A", "gene_name": "Fam228a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADTKTSKCDEHFSVEKLKEWPEPESVSLMELLAREDIDEAVHAVLFRENYVVKRLDTYLQHLAVFKERRKEMLHKKWVENVVQPLQQRITDKITSYRRPGKNQVKYEHCLKQTNKPTKVSSSCLFQKQQEFREAKGTSYQHGRGKTHDTQKEAKETEKGLSFTPFSLRPHCSSPRERQRASARLMQSKPGGRNRYKGASSEKPVFTLKSHLPKEEKTVSRSQLVFERQFRASRLSQDIKEAEKKGLVVGTGPQRPRSWAAADSVPRPSLVGRRVMTAEILGEHLVSLHQAARSGLQWP", "length": 299 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8CEK3-1", "protein_name": "Serine protease inhibitor kazal-like protein, minor form", "gene_name": "Spinkl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSTWIKFLFILTLVLLPYSVFSVNIFAGPENVIKEPNCTMYKSKSECSNIAENPVCADDRNTYYNECYFCIEKVVEKLKYRYHGICIYK", "length": 90 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IZP1-1", "protein_name": "TBC1 domain family member 3", "gene_name": "TBC1D3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKKGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF", "length": 549 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K072-1", "protein_name": "Receptor expression-enhancing protein 4", "gene_name": "Reep4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVSWMICRLVVLIFGMLYPAYASYKAVKSKNIREYVRWMMYWIVFAIFMAAETFTDIFISWFPFYYEFKMAFVLWLLSPYTKGASLLYRKFVHPSLSRHEKEIDACIVQAKERSYETMLSFGKRSLNIAASAAVQAATKSQGALAGRLRSFSMQDLRSIPDTPVPTYQDPLYLEDQVPRRRPPIGYRPGGLQGSDTEDECWSDNEIVPQPPVRPREKPLGRSQSLRVVKRKPLTREGTSRSLKVRTRKKAMPSDMDS", "length": 257 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8MP30-1", "protein_name": "Uncharacterized histidine-rich protein DDB_G0274557", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEIKYFLVLLVGFLLVLPSIVNPYRKGVTITNQQPKINIYQLDVNNPHNPNNNPHNPHNPNNNPHHPHHLHHHHHHHHHHHHHHHHHHHHHHHHHHPHHPHHHPHHHHHPHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHPHHHPHPHPHPHPHPHLHPNPHPHPHPHPHPHPHPHHHPNPNPHPHPHPHPHHHHHHQEASECLSYQGNRNRLFIKRDY", "length": 233 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8NG83-1", "protein_name": "Olfactory receptor 2M3", "gene_name": "OR2M3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARENSTFNSDFILLGIFNHSPTHTFLFFLVLAIFSVAFMGNSVMVLLIYLDTQLHTPMYLLLSQLSLMDLMLICTTVPKMAFNYLSGSKSISMAGCATQIFFYTSLLGSECFLLAVMAYDRYTAICHPLRYTNLMSPKICGLMTAFSWILGSTDGIIDVVATFSFSYCGSREIAHFFCDFPSLLILSCSDTSIFEKILFICCIVMIVFPVAIIIASYARVILAVIHMGSGEGRRKAFTTCSSHLLVVGMYYGAALFMYIRPTSDRSPTQDKMVSVFYTILTPMLNPLIYSLRNKEVTRAFMKILGKGKSGE", "length": 312 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8NGV6-1", "protein_name": "Olfactory receptor 5H6", "gene_name": "OR5H6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFLYLCFIFQRTCSEEMEEENATLLTEFVLTGFLHQPDCKIPLFLAFLVIYLITIMGNLGLIVLIWKDPHLHIPMYLFLGSLAFVDASLSSTVTPKMLINFLAKSKMISLSECMVQFFSLVTTVTTECFLLATMAYDRYVAICKALLYPVIMTNELCIQLLVLSFIGGLLHALIHEAFSFRLTFCNSNIIQHFYCDIIPLLKISCTDSSINFLMVFIFAGSVQVFTIGTILISYTIILFTILEKKSIKGIRKAVSTCGAHLLSVSLYYGPLTFKYLGSASPQADDQDMMESLFYTVIVPLLNPMIYSLRNKQVIASFTKMFKSNV", "length": 325 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R264-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r215", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNWNNIIHTIIFLSLTGPGIVGNMLIFIRHIYMPALGTEKKPVDLIVIHLAFSNMITICTTGIKDIATVFYFRNFLGDIGCKAVVFLARMARGLSICTTCLLSVVQAITISPRTSLWTKLKPQTACQIIPFILVFWIFNGLISSNLLSYIKGGSSLNRSVAATFIGHCYMLQSRHTIKWIFLSLMTLRDVIFQSLMGWSSGSMALNLYKHHKRVLYLYSSRFANNSPPEIRATWSVLILMTCFLLFYWADFILSFYHGFTVTHESILLNIKVFLELGYVSFSPYVLISRYIHPPNVFHAH", "length": 300 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R272-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r220", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVLQFIKKTIFLFMTMVGILGNMSVSVHYMFSWWGSPEKKPIHLILTHLTFTNIILLLAKGLQKTIIVFGLRNFLDDIGCKIIVYLERVARGLSICTSSVLTVVQAIIISPRASGWRRLRPKSAWHILPFFSFFWILNAFISVNLIHSIRSKGMNTSQHKNSDDYCYLTPESQKIKWIVLPLMVLRDAVFQGAMGGASGYMVFLLHKHHQHVLYLQNSKLLYRTPPELRAAQSVLLLMLCFLFFYWTDCALSLFLSLSLGDSSLMINIQGFLTLGYAIFSPFVLIQRDGLIPVCWHAQ", "length": 298 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R278-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r213", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLALRNYIQINTPWCMCLFVTPLTPCLPEYWDPDSLRVEGPTESSLRHNTASCTLKNTIMQNVQFRSMSSITDAFFKMYLHTRKEEMILKILKEITFLIMTVLGILGNMSVSVNYMFSWWGSPEKKPIHLILIHLIFTNIIILLVKGLPKTIAAFGLRNFLDDIGCKIIVYMERLARGLSICTSSLLTVVQAIIISPRASGWRRLRLKSAWHILLFFLFFWILNALISVNLIHSTTNTRLNVSQLKSDDNYCYFMLPIQKIKWIVLPLMVVRDAVFQGAMGGASGYVAFLLHKHHQHVLYFQNSKLLYRTPPELRAAQSVLLLMLCFVFFYWTDCAFSLFLTLSSEVNILMVNTRDFLTLGYATFSPFVLIHRDGLLVECRHVQ", "length": 384 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R2A9-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r229", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDFGNLAMGIVLSLQSALGILGNFSLLFYYLVLYNKERTLKIIDIILIHVFTSNSLIIFSKGLPEVLAVFGWNDLFDDVGCKLIMYVRRVSRSMSISMTCLLSVFQAITISTRNSCWKEFKEQTAKFMGLFISLCWILFMLVNMLFPVYTSTNRNSKNKTQKKDIEFCHSVGRDKMVDIMYTAFCVFPEVLFSLLIVSSSTTMIVILYGHKKRVQHILHTHASPRTSAENRATQTILILVCTFLAFYTLSSVLQGYVALSHDPSWWVMNITTIISMGFPAIGPFVMSRDFTVSRFCFTCIGNLKLP", "length": 306 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R2B6-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r178", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAHDKSLKTTDDMTLQILLLCQFVVGTVANVFLFLHNISPVLTGSKQRPRQLILSHMSVANALILFLTSFPDMMAFAPRNSPTHLKCKLEYFSRLVARSTNMCSTCVLSIHQFVTLVPVNRGKAILRASVPNLTSYSCYSCWFFSVLSNIYIAIKVTGPQITDNNTDSKSKLFCFTSGFSVGIFFLRIFHDGTFMSIMVWTSVSMVLLLHRHRQRMQHILTPNQDARGQAETRATHTILMLVVTFVSFYLLNFICIIFYTFSIDSRLFMSHFSKVFAAGFPTISPLLLIFRDPKYPCSVLFNC", "length": 304 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R2B8-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r64", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSQNKTLKTMEVLALQILLLCQVVVGTVGNIFLFVHNFSPVLTDSRLRPIQVILINLAVANAFMLLLFAYSYDLIDFVPRKPPTDLKCKLAYFFNMVAQGTIMCSTCLLSTYQFVTLVPGNWARVMFREISPKVVSYCCYSCWLFSVLNNAYMPMYVSGPQKTHNDSDSKDNWICSISGVSVDMNFLRFSHDIIFIGIMAWTSVSMVIHLNRHHHRMHYLHNPNQINRGHAETKAAHTIMMLVVTFVSLYILDCICSLFHISFVESRLWLIDVIELLHLSFPTVSPFLLICRDPMGPCSLLFIVGLEIHVTVGAITEEQ", "length": 320 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R2B9-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r59", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEMLALQILLLCQVVVGTVGNILLFVHNFSPVLTDSRLRPIQVILINLAVANAFMLLLLTYSHDMIDFVPRKPPTDLKCKLAYFFHMVAQGTIMCSTCVLSTYQFVTVVPGTWARVMFREISPKVVSYSCFSCWLFSVLHNAYIPMNVSGPQKTHNDSDSKGNSICSISGVNVDMHFLRFSHDIIFLGIMAWTSVSMMIHLNRHHQRMNRIHKVNQNNRGHAETRAAHTILMLVVTFVSLYILNCISILFHISFVESRLWSRHVIKVLALSFPTISPLLLIFRDPRGHCSLLFSVGLEIHVTGGVITEEQ", "length": 310 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R2C0-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r62", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVLALQILLLCHVVVGTVGNILLFVHNFSPILTDSRLRPIQVILINLAVANAFMLLLFAYSYDLTDIVPRKPPTDLKCKLAYFFHLVARGTIMCSTCVLSTYQFVTLVPGTWARVMFSEISPKVVSYCCYSCWLFSVLNNAYMLMNVSGPQKSHNDSDSKSNSICSISGVSVDMNILRFSHDIIFLSIMAWTSVSMVIHLHRHHQRMNHIHKVNQNNRGHAETRAAHTILMLVVTFVSLYILNCISILFYISFVESRLWLRYVTKLLALSFPTISPLLLIFRDSKGHCSLHIMSVWKST", "length": 300 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R4R9-1", "protein_name": "Protein phosphatase 1 regulatory subunit 14C", "gene_name": "Ppp1r14c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVVTGGGEAAGGTSGGGARVFFQSPRGGTGGSRESSSHSGSSREDSAPVATVAAAGQVQQQQRRHQQGKVTVKYDRKELRKRLVLEEWIVEQLGQLYGCEEEEMPDVEIDIDDLLDADSEEERASKLQEALVDCYKPTEEFIRELLSRIRGMRKLSPPQKKSV", "length": 164 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R4V1-1", "protein_name": "NFAT activation molecule 1", "gene_name": "Nfam1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESWLLRRGARVRCLHPPSWLPAWCFLCLLPVPQTLQLTGLVSLTHTSLPIMVSLANTDVFFSCRIEDFTRLQRDLPVKLFHTDIHGRRRWEKQINCQHRPGMENHTRDCMVKLSQANTSATGIYYFIVEGEETYQSDGVVILVRDTVYQPPAFKVQEALMLGFTSLMSVLGVLGTALLLWKKKQISVLGKHTAKTCSGLKSTVGTTKPPAESVYTSLQRRETEVYACMKEETGSPVFSQSPATKEKLNRFEDDNEFNLVYENL", "length": 264 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8T277-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma", "gene_name": "prkag", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MWYPGDEDEEFTSIIENIEKKETQEIKIKTEKLRQASLNQLPIEQSEGVGGGELSEYNNNTTNNNTPTNTTTTTNTNTTTMNNSNNNNERILSTSNGFDIRLPPNSIEQPSPSFISSSQDGVLTVDPLAVDGEKGNKESQSPPNGDNQILNNNNMFFKDITSLPSTDNKSSTNTNNNNNENPLKQTISSSPSKSTTTTTTSTSTTTTPSLSSLSSNNNNNSNSNNNYINHSSISTVSEGLENLNLKSGIKKIDSETEKYIEEGKQVFVNFLKGHTCYDVIPISGKVVVLDTKLAVKSAFYALEENGIKSAPLWNSEQHDFTGMITVSDFIDILLYYYKKPKSNNIFQDMGIHRIETFWREISVERPSSLISTEPETNLYDAASLLLCYKIHRLPVVDKKDTNSILHILTHSRILAFMMKSFPQLPEKLLSIPIGSLGIGTFATVVTVMTHTPLVEVLELLSEKKISAVPIIDSETSKIVDVYSKSDVTLMSKQGILSPSDLNLPVHQVLSTFTKLWQRPEQIYTCTRFDKLGDVIERCIKKRVHRLVCIDSSKKVEGILSLSDILNYLLNDVKSINH", "length": 577 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8VEU4-1", "protein_name": "Olfactory receptor", "gene_name": "Or14j2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIVENITTMRGFLLMGFSDNHELQILQALLFLVTYLLGSAGNVIIITITTLDPQLQSPMYYFLKHLSILDLSSLSVTVPQYVDICLTQSGYISYAQCMLQIFFFTGFAWGEVAILTVMSYDRYVAVCLPLHYEVIMGPSKCRWAVTAVWLSSVIPGTLYIASIFSIRFCGDRIIHQFFCDVPQVLKFSCSDDYLVTVGVADFLSAVAFACFIGIVNSYVHIFSTVLRMPSAESRSKVFSTCLPHLFVVLLFLSTGIFAYLNPTSDSPTALQFLVSIFYTVLPPTLNPVIYSLRNETIKSVIRKLLLSSKFTG", "length": 312 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8VFX0-1", "protein_name": "Olfactory receptor", "gene_name": "Or5b101", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MENRTEVRCFILVGLTNDPSLQLPLSITFLLIYIITLIGNLGLILMILLDSRLHTPMYIFLGNLSLVDFCYSSTVTPKVIAGFLTGDKIMSYNACASQMFFFANFGDVENYLLASMAYDRYVAVCKPLHYATTMTTHMCASLVIGCYICGFLSASIYTMDALSLSFCESNVIHHFFCDVLAVMIVSCSDSHVNELILIYVVSFNMFFALIIILISYMFIFTNILKIHSSAGYHKAVSTCASHFTAVSIFYGTIIFMYLQPSSSHTMDTDKIASVFYTMVICMLNPLVYSLRSKDVKSAFTKIVLRSK", "length": 307 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8VY69-1", "protein_name": "Vesicle-associated membrane protein 723", "gene_name": "VAMP723", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAQQSLFYSFIARGTVILVEFTDFKGNFTSVAAQYLENLPSSNNKFTYNCDGHTFNDLVENGFTYCVVAVDSAGREIPMAFLERVKEDFYKRYGGEKAATDQANSLNKEFGSNLKEHMQYCMDHPDEISNLAKAKAQVSEVKSLMMENIEKVLARGVICEMLGSSESQPQAFYIKRTQMKRKKWFQNMKIKLIVLAIIIALILIIILSVCGGFNCGK", "length": 217 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8VZ67-1", "protein_name": "Uncharacterized zinc finger CCHC domain-containing protein At4g19190", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDGEGEGSGIRLSKRFAGGKVTGGSLEVDYKTKSGTAWSHSFLNQKPWHPLSYPNQRRKWIAEQTHAQHDRRAEEVAREFAQEQEFFKQAALISKKEREKIETMKAVSFMYVRPPGYDPESAKAAEYKDEKHKGQGSSTQDPVADDNVGSRPEESQGGGERTQERKKPRPKDVFGRALPTEEEFEVLKNAPRMETGIPGRVKPFAVEVRNVKCLRCGNFGHQSGDRDCPLKDAVMPNEELRLKRDDPLTAIIAHTDPSEPLKWELKQKPGLSPPRGGFDPDDPNQQIVAEDIFDEYGGFLEGSIPIEILKSMSSDKKRKSKKNKRHKKHSSRTVEETDESSTGSEDSREKRGSKKRKKLKKKSKKQYDSDSLSFEGSGSDSYRLSRRRHTKHVDPSASLKSEVYHQGNSHREKHYYDEKHQKRKEIVDRPSASSDDSDYYRSNSSRKKRSEDDYKSHHRERKQVHSNDPVSEKSQKQHYSESGKIQRVEKEHRYDERRHRYVDMESENRNRSEKKPRYDDRDSEKHHRSVKGKEKHVYEASDDPEEFSDRYRSTKKTESDSESNRRSRKKKHELSSEEEEGESRKHRYSTNRRRN", "length": 595 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q91V82-1", "protein_name": "Beta-defensin 8", "gene_name": "Defb8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRIHYLLFTFLLVLLSPLAAFSQKINEPVSCIRNGGICQYRCIGLRHKIGTCGSPFKCCK", "length": 60 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q923B3-1", "protein_name": "Neurotrophin receptor-interacting factor 1", "gene_name": "Nrif1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASTLPTTWPHESVKFEDVSLTFTEEEWAQLDFQQKCLYREIMMENYSNMISVEHHFSKPNVISQLEKAEDCWPMQREIPQDTLPECSWPSPDPGMNSFPSKSPLMKIEVVEVLTLNKDVAGPRNALIQSLYPEDLNPGNLKPAQQPSKRLTDTEASRQKFRHFQYEESAGPQKAMSQLRKLCHQWLQPNTRSKKQILELLVLEQFLNALPEKFRVWVESQHPEDCKAVVALLENMTSVSKDDASLACSSEATDQLKEKRKGVATLPVTFAAEVPAEEPVTFQDVAVDFNEEEWRLLGPTQKTEYHDVMLETLGNLVSVGWEPTLGNRELTPDSPIPVVKPIHDPNTNDLSRNGTQSTVFESILEDGVKEMHSIESNQVGNLQEKGHPQKKFSESSKSQDQTSRHKSQGSLNEVLPRKYVKVKQKGTGKRKGRTNTISMTRGLRIRKQQKDSVEWQGRSGSTPVTHGSSIKKQQQGSEQGKPGTSRDPITLTVPAKVYQKATGSEESIFMDSSDAMVPDVPPKIHQKGPEWHKVGESNNSMLQGSSVQNHQMESGAGRASDNSLLTHALPVKSHQKGYKEGNVQGNRNSWKHIKPHQKGSKGERVEELSTSEKHVPYVKNHLKTSERGKDREINASIKCDPYIKTYYRGSDVGRLRRANNCRKAFSLHAQQISFIKIHKGSQVCRCSECGKLFRNARYFSVHKKIHTGERPYMCMACGKAFVQSSSLTQHLRIHSGERPFECSECGRTFNDRSAISQHLRTHTGAKPYHCERCGKAFRQSSHLTRHERTHTGERPYVCIKCGKAFTQSSHLIGHQKTHGIKFKKQPKL", "length": 828 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q924S2-1", "protein_name": "Inactive 2'-5' oligoadenylate synthetase 1C", "gene_name": "Oas1c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MENGLCSIQARELDEFICDYLFPDTTFLTELRADIDSISAFLKERCFQGAAHPVRVSRVVMGGSYDEHTALKGKSEAKMVLFFNNLTSFEEQLKRRGEFVEEIQKHLCQLQQEKPFKVKFEVQSSEEPNSRSLSFKLSSPELQQEVEFDVQPAYDVLYELRNNTYAEPQFYNKVYAQLIHECTTLEKEGDFSICFTDLHQNFMRYRAPKLWNLIRLVKHWYQLCKEKLREPLPPQYALELLTVYVWEHSNKNQEKVTTAKNFRTFLELVAYYKNLRIYWTWYYDFRHQEVCAYLCRQLKKARPLILDPADPTRNVAGSDLQAWDLLAKEAQTWMQSSCFRNCDMSFVPTWDLSPERQECAFQ", "length": 362 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q925U0-1", "protein_name": "Oocyte-secreted protein 1", "gene_name": "Oosp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKPFVGLLGLLLLLSFMKTCADDWTAISLQCADHWFHLRIRPTIFHNIFMEPDEVFLGIGCPVTTTWPNDTYEFIYRTYSCGIANKVLCDVTLLKTQLTYISKNASLQAEMSLSCVMHNQSPHFCEAESRGDFTGDPPGWTEDMRARRDEQTVPMVQPNLSTSSEDHHVSTEPWASETSRSEAAEVPSFMDQNFSVFHFSRM", "length": 202 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q94490-1", "protein_name": "Ubiquitin conjugating enzyme E2 B", "gene_name": "ubcB", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MAAHKRLQKEITDMLKTPPSWCSAHLVDDNLQKWKATVQGPEGSPFEKGVFSMDIDIPADYPFKPPTLKFTTKIYHPNIKTSDGAICAEVFSTWSPQLKILDVLTTIRSILTDPNPDNPLETEIAQQFKTDRNAFNKTAKEWTKKYAK", "length": 148 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q945S5-1", "protein_name": "Vacuolar cation/proton exchanger 4", "gene_name": "CAX4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSSISTESSSNLSLLENGGGGSDKPTAETSRRVRRTVSASSLIRKRSDLKLISRVRWEFMRRILTNLQEVLLGTKLFILFPAVPLAVVAHRYDCPRAWVFALSLLGLTPLAERISFLTEQIAFHTGPTVGGLMNATCGNATEMIIAILAVGQRKMRIVKLSLLGSILSNLLFVLGTSLFLGGISNLRKHQSFDPRQGDMNSMLLYLALLCQTLPMIMRFTMEAEEYDGSDVVVLSRASSFVMLIAYLAFLIFHLFSSHLSPPPPPLPQREDVHDDDVSDKEEEGAVIGMWSAIFWLIIMTLLVALLSDYLVSTIQDAADSWGLSVGFIGIILLPIVGNAAEHAGAVIFAFRNKLDITLGIALGSATQIALFVVPVTVLVAWTMGIEMDLNFNLLETACFALSILVTSLVLQDGTSNYMKGLVLLLCYVVIAACFFVSNSPSSKLLF", "length": 446 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q96AK3-1", "protein_name": "DNA dC->dU-editing enzyme APOBEC-3D", "gene_name": "APOBEC3D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVLPKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFLAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEDFAYCWENFVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ", "length": 386 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99N64-1", "protein_name": "Germ cell-less protein-like 2", "gene_name": "Gmcl2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLVSRVLRCRDSSLLEPQPEAIAGASYIPGSRKRKRNSLEELATSSNVHGPQNQGMYPHQVLNYIYWKRVKISSNDAYQNLFLDGHDSDIKIRALGRTWCLHKVFLCQSGYFANILKGTWRESHHGVINLIIKNEDIDTRSLHFVFGALYTDADLSITPLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFLYLNPCWNGTMKQLLQHANNWLSTHMAYVDNISFLESEEGLIFQPVFKKLRFQHIICDLTSTTILEQDRLIPMAWLSPIYKQQWLTLLRTQEYGVIGPQVINEQELEECTMRCGTMIPKDGRYTWKWSVGRLGFPLRVTFTRQCVILRQRCQRCDGSACHNHIRNVIFRITLVCFDSNKRVTFRKTTGYKILTFEYKEEQIVMKLDSDVLTFPMCIFCNFLFVNLGNAENK", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9C7P4-1", "protein_name": "Putative zinc finger CCCH domain-containing protein 9", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MADAGDNQQEAERRSDETESRSIKEPKEKEDEDENPQDQIQSKERMRQSSPYPVRPGKKDCQFYLKNGLCRYRSSCRFNHPTQRPQELPVRICKHIMDRNVAEPMYQDWRESESERRFDERTQRTFGDERTQRRYGIEYSGARPEKRSKIVPDFQMRDPRHHDTEWRFERERMERIERQRREAEENLQEQRQRDSIERQRREAEENLQEQRQRDSIERQRREAQENLQQQRQRDSIERQRREAQENLQQQRLQDMPENHNVDDQQNLQEQRRISIEKERTEARLRLEQIRPTVSFPINEFIRAVVLLRELIENWDDKAWKK", "length": 321 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9C8M4-1", "protein_name": "DNA-directed RNA polymerase subunit 12-like protein", "gene_name": "NRPB12L", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDLQQSETDDKQPEQLVIYVCGDCGQENILKRGDVFQCRDCGFRILYKKRILDKKETRIGV", "length": 61 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9CQK8-1", "protein_name": "Small proline-rich protein 2A1", "gene_name": "Sprr2a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSYYQQQCNQPCRPPPVCPPPKCPEPCPPQVWPGPCRPVMCFEPCLPSVWPGPCRPVVCYEQCPPQPWQSTCPPVQFPPCQQK", "length": 83 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9CWP4-1", "protein_name": "Lymphocyte antigen 6K", "gene_name": "Ly6k", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFLVALLVVLGLQLVQSNALTCHVCEAQNSYACSNPSQCPGEKKFCLLAVTRIFERFFYVSKQCTRRCPTPVVSPPSTNPPSEPKEFLIEKPMPFLFYKCCQWDSCNGEGPPTDQLLKEQPGKASGRRHRYIELLLTGFMVLTANGLSALCLL", "length": 154 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9D541-1", "protein_name": "Coiled-coil domain-containing protein 7A", "gene_name": "Ccdc7a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKCAKHPSTISMKLTSVPELPYKKGLLNSSPKPKEKHNAKSKYGKNESMVLRSPPTGESIVRFALPIPLSKTKDKISADEMVRRITTNLKMVVSNLEDTYGACYDNGEKAAEKSEAEGLSIGDDVSSFLLCCSQFTSQLEEAVKEECGALESLYKWFQQQVNQMEEISKDQSNLEELQSDGKTASLNIVQIAKLARKFEDFKSRLKTRKEVMQTKNEDKEIMAETLKHYGLMEKQIEEFITSHSALESQTETESQSGTPSVTTRMARMIKIFENQSTMLEKALNDQQTIESKYKQLETDFQMLIMEKTLLEAEIRRLREIERVKSAAKEEQTKKSGKSEKKKFKEKEKNLSPNREFKSIEELLQIQKEAELLKTEKKTLQGQLKWALEEAERNKTQLEFVLHQKMEMFKEESKTKVGQSQNKSKVKIEDSKDSLPKKSDTQLGGQRKDQISSDQSKRPKKKQLADIDPSAVEDFPPETFKSFTVMPLIEEHRESISSQPKEEMAKASEQSEAEDIEGPLEIPSESSNEDDDLLPEDESPMMEQVTDVGRYKSIYISAEPIDTMSLISRTQSEMETLEAINYDNVLNEGEEQDKKIGKDSDTGRKSKRKRSSKIRKLSTHEEESDIVHYEEATKAKVPSKKRASDPYGDEAYESRGSVSKAQTYTKKQGTHQRGRGSASDAYGDEAYESRGSISKAQTYTRKQGTHQRGRGSVQEEESDTVHYEEVTRAKVPSKKQASDPYGDEAYESQGSVSKAHTHTKKQGTHQRGRGSVHEEESDTMNYEVPRKSKISSRRKGFALPITHQVEMHSSESQGSISKSNTETKKQGTHKRGRDSDADGARTPVSQGSDSKADTERKKHRSKEESTISKDSIPVLDEVQDKTFEHQESGLRLEVQAKKLTFSSQNIHNEESATDIKVEYQNVPSSSQVQLKKQKPLGGEIFTTHFVVPAESHAQLYQTHTPETQIERGTTSGTARLTTIPVEHPKKEASPDNLFPEKKLYITRAPTQTKKQYPPWDAKAETQKKTVKEVQGISEPQTKLNPTMSGIILHLDMDRVVETDLENLEETIVPHVLRSELEIGTDAKNMPETPTSREAVRTEAKGNQDVTISIAKGMKLIGKLKDQHGLSSFASKDTISPGKSLIKSSRDNQDDSLLETKPQENTSDKYHPSKTFPTKVINMLPFSEKSLGSTSANVDVAPKPVYRASRGRSRISKALQQLLKTSEHLKPTSTKNQNADLEKHLYISVRSANKHTQKDKKHGQSNNQKLKKQGALSSTKKQKHKEQPKTETIVENNDKFDDNLMMTTSSPNIKIIKELSKTLNLDGGDIELSDFVFKTASAAKKLENKGPSKTKNLNKESSRDIHILHLTTSAIRTLLLDEEAKIRSLEKKLMKQSTILQKSVSSMKKFMFEEPSRETKMKRKKREKRKIVVKSPHILPITTTQKHTIKEKSEISNLEKPIVRGTDILKKSTSARKKRVLKGKSKSATLPKKCDNFPFDLVRSSSDSSKQEVEEQPKPGNVDKKVSDDSYSPDISTTPTKKHTLKGQSKSRTIYEKGVDLPNNLVLSKSASSIQEFEEQPQPGNVDKKVSDDSYSPDISTSPTKKHTLKGQPKSENSDEKGIKRPNNLHMSASVARKRLLKALSTIP", "length": 1642 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9D5R2-1", "protein_name": "WD repeat-containing protein 20", "gene_name": "Wdr20", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATEGRGKETNEIKTHFTTREGLYRLLPHSEYSRPNRVPFNSQGSNPVRVSFVNLNDQTGNGNRLCFSVGRELYVYIYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSDSLFLVAHSSGNMYSYNVEHTYGTTAPHYQLLKQGESFAVHNCKSKSTRDLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSAELHGTMKSYFGGLLCLCWSPDGKYIVTGGEDDLVTVWSFLDCRVIARGRGHKSWVSVVAFDPYTTSVEESDPMEFSDSDKNFQDLLHFGRDRANSTQSRLSKQNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARAHANVMNATGLPAGSNGSAVTTPGNSVPPPLPRSNSLPHSAVSNAASKGSVMDGAITSGVSKFALLSLHDRKERHHEKDRKRNHSMGHISSKSSDKLNLVNKAKTDPAKTLGTSLCPRMEDVPLLEPLICKKIAHERLTVLVFLEDCIVTACQEGFICTWARPGKVSKFQP", "length": 567 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9DAF8-1", "protein_name": "Uncharacterized protein C4orf51 homolog", "gene_name": "", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTHFLYLTPEILLPFSPLTSTEFELIRRKAQQLWQDETRWSASSMTTYSGSYREKQLDEATCNRLAQRVGQPQFEYKPTPLPGSSAYNTLPGHAGSQEAADGKGRLPDIASPSRDSPLNIKHKVAHQIWGSEVPCPTFLAYRGLRMSPCMQPKKPGFELLMSYRNRGKALLKRLQRQWDYESKLGSSEDSGTDRFSSNTSGSSGRKFK", "length": 208 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9EPV9-1", "protein_name": "Beta-defensin 5", "gene_name": "Defb5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKIHYLLFAFLLVLLSPLAGVFSKTINNPVSCCMIGGICRYLCKGNILQNGSCGVTSLNCCKRK", "length": 64 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9EPX4-1", "protein_name": "P2Y purinoceptor 12", "gene_name": "P2ry12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVPGANATSANTTSIPGTSTLCSRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGHLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVAIWAFMFLLSLPNMILTNRRPKDKDITKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKAPKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCNAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLMSMLRCSTSGANKKKGQEGGDPSEETPM", "length": 343 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9ER80-1", "protein_name": "Receptor-transporting protein 4", "gene_name": "Rtp4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLFPDDFSTWEQTFQELMQEEKPGAKWSLHLDKNIVPDGAALGWRQHQQTVLGRFQCSRCCRSWTSAQVMILCHMYPDTLKSQGQARMRIFGQKCQKCFGCQFETPKFSTEIIKRILNNLVNYILQRYYGHRKIALTSNASLGEKVTLDGPHDTRNCEACSLNSHGRCALAHKVKPPRSPSPLPKSSSPSKSCPPPPQTRNTDFGNKTFQDFGNRTFQGCREPPQREIEPPLFLFLSIAAFALFSLFTR", "length": 249 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FFP9-1", "protein_name": "Serine/threonine-protein kinase SRK2H", "gene_name": "SRK2H", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDKYEVVKDLGAGNFGVARLLRHKETKELVAMKYIERGRKIDENVAREIINHRSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEAEARYFFQQLICGVDYCHSLQICHRDLKLENTLLDGSPAPLLKICDFGYSKSSLLHSRPKSTVGTPAYIAPEVLSRREYDGKHADVWSCGVTLYVMLVGGYPFEDPDDPRNFRKTIQRIMAVQYKIPDYVHISQECRHLLSRIFVTNSAKRITLKEIKKHPWYLKNLPKELTEPAQAAYYKRETPSFSLQSVEDIMKIVGEARNPAPSSNAVKGFDDDEEDVEDEVEEEEEEEEEEEEEEEEEEDEYEKHVKEAHSCQEPPKA", "length": 360 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9FLZ3-1", "protein_name": "SNF1-related protein kinase catalytic subunit alpha KIN12", "gene_name": "KIN12", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDGSSEKTTNKLVSILPNYRIGKTLGHGSFAKVKLALHVATGHKVAIKILNRSKIKNMGIEIKVQREIKILRFLMHPHIIRQYEVIETPNDIYVVMEYVKSGELFDYIVEKGKLQEDEARHLFQQIISGVEYCHRNMIVHRDLKPENVLLDSQCNIKIVDFGLSNVMHDGHFLKTSCGSPNYAAPEVISGKPYGPDVDIWSCGVILYALLCGTLPFDDENIPNVFEKIKRGMYTLPNHLSHFARDLIPRMLMVDPTMRISITEIRQHPWFNNHLPLYLSIPPLDTIDQAKKIEEEIIQNVVNIGFDRNHVVDSLANRIQNEATVAYHLILDNRNQNSVPNDPFQSKFKEISDGIFNSTLPVQNITSHVGHSFSALYGLKSNVKDDKTWTLGLQSQGSPYDIMTEIFKALQNLKICWKKIGLYNIKCRWVRSFAYYKNHTIEDECAIILPTVIKFEIQLYKVREGKYLLDILRIDGPQFIFFDLCVAFLRELGVL", "length": 494 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9FVV4-1", "protein_name": "DEAD-box ATP-dependent RNA helicase 55", "gene_name": "RH55", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDSSPPNTIIEEAPPRFSELKPPLSEDIIEALDRSGFEVCTPVQAETIPFLCSHKDVVVDAATGSGKTLAFLLPFIEIIRRSNSYPPKPHQVMGVIISPTRELSAQIHKVARAVRLDFAKCREVEADMNTLEEEGANLLIGTPGRLSDMMKRMEFLDFRNLEILILDEADRLLDMGFQKQVNYIISRLPKQRRTGLFSATQTQAVADLAKAGLRNPYLKCEADQKSSQLVHLLIENKNKKLVVFFMTCACVDYWGLVISKIPSLKSISFFPTHGKMDQKGRDTALASFTEASSGVLLCTDVAARGLDIPGIVYIRSLAIKDREVLEKGLKAFVSFVRAYKEHQCSYIFSWKGLEIGKLAMGYGILSFPYISEVKQDRIGIVGFTPVQGITFEDIKFKNKSREKQRQQNLLARKDKLQQEKRGKRKKSSKEAVDDSNKASRKRKLTGRQRQTIQTAQDEEEMNLRL", "length": 465 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9JI02-1", "protein_name": "Secretoglobin family 2B member 20", "gene_name": "Scgb2b20", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGTLLLLGLLVTGELSFQTTEACLPFFEGYASVLSGSRVWLYQELQAFNATAEEKVALEKIQDCFSEERIRNILLEPKIMEAMVASPECLSYYGLDNIRSILDYISKLLGE", "length": 112 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JJQ7-1", "protein_name": "X-linked lymphocyte-regulated 4B", "gene_name": "Xlr4b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASKIKGRPPKQPKVTPALPSNDSQQLHENNPGNNLALETCGESSSSHGTGGPKPGPSKKTLNERKRKYGVSVNKTVQNIEWNVDHFLKVQHERRQELYKDYSHQFLTLVMMWNIDVDQIKKQAGKLSDILDEQQKLFQQFQSIHMQKIEEFKELCDRHLKNLQAIKCCRRKAIIEEARKLMDYLEKRVTEETVHVNKQEAKDGVQSSLLSLLIS", "length": 215 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JLV9-1", "protein_name": "Prolactin-2C5", "gene_name": "Prl2c5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPSLIQPCSWILLLLLVNSSLLWKNVASLPMCAMRNDRCFMFFEDTFELAGSLSHNISIEVSELFTEFEKHYSNVPGLRDKSPMRCHTSFLPTPENKEQARHIRYEALLKSGDMILDAWENPLDYLVSELSTIKNVPDIIISKATDIKKKINAVQNGVNALMSTMNGDEENKNPAWFLQSDNEDARIRSSYGMISCLDNDFKKVDIYLNILKCYMLKIDNC", "length": 222 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LJY9-1", "protein_name": "Cytochrome P450, family 705, subfamily A, polypeptide 18", "gene_name": "CYP705A18", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATLISVDFQHCFMYIILLCLFSLLCYSLFFRKPKGTRVGCDLPPSPPSLPIIGHLHHLLSSLTHKSLQKLSSKYGPFLHLRIFSVPIILVSSASVAYEIFKAHDVNVSSRGAAAIDESLLFGSSSFIYAPYGDYWKFMKKIFATKLLRPQVLENSRGVRAEELKRFYRRILDKARKNENIEISKESAMLMNNILCRMSMGRSFSEENGEAERVRGLVGESYALVKKIFFAATLRRLLEKLRIPLFRKEIMGVSDRFDELLERIIVEHKDKLEKEHQVMDMMDVLLAAYRDKNAEYKITRNHIKSFFVDLFVGGTDTSVQTTQWTMAEIINNPNILQTLRKEIDSVVGKSRLIHETDIPNLPYLQAVVKEGLRLHPPGPLLIRTFQERCEMKGFYIPEKTTLVINAYAVMRDPDSWEDPDEFKPERFLSYSRSGQEDEKEQTLKYLSFGGGRRGCPGVNLGYIFVGTAIGMMVQCFDWKIEGDKVNMEETYGGMNLTMVNPLKCTPVPRTQPFSFTSNLEILSS", "length": 524 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9LSY1-1", "protein_name": "SKP1-like protein 8", "gene_name": "ASK8", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSTKKIMLKSSEGKTFEIEEETARQCQTIAHMIEAECTDNVILVLKMTSEILEMVIEYCNKHHVDAANPCSDDDLEKWDKEFMEKDKSTIFALTNAANFLNNKSLLHLAGQTVADMIKGNTPKQMREFFNIENDLTPEEEAAIRRENKWAFE", "length": 152 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9LTG5-1", "protein_name": "Callose synthase 4", "gene_name": "CALS4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MNQPNRGQILQTVFSHFFPVASPDSELVPSSLHEDITPILRVAKDVEDTNPRSLFLQDLDIKSVDDSINILSGHSHALDKANELDPTSSGRDVRQFKNTILQWLEKNNESTLKARQKSSDAHEMQSFYQQYGDEGINDLLNAGAGSSSSQRTKIYQTAVVLYDVLDAVHRKANIKVAAKILESHAEVEAKNKIYVPYNILPLDPDSKNHAMMRDPKIVAVLKAIRYTSDLTWQIGHKINDDEDVLDWLKTMFRFQKDNVSNQREHLILLLANVQMRQTQRQPNLLDDRALDTVMEKLLGNYNKWCNHVGLESSLRFPKDKQQKVVQQRKLLYTGLYLLIWGEAANLRFMPECLCYIYHHMAFELFEMLESKGSKKKYKPKNPTYSGKDEDFLTKVVTPVYKTIAEEAKKSGEGKHSEWRNYDDLNEYFWSKQYLDKLGWPMKANADFFCKTSQQLGLNKSEKKPDLGDGCVGKVNFVEIRTFWHLFRSFDRMWSFYILSLQAMIIIAWNETSESGGAVFHKVLSVFITAAKLNLFQAFLDIALSWKARHSMSTHVRQRYIFKAVAAAVWVLLMPLTYAYSHTSIFIVAILIYLSPNMLPEMLLLIPSIRRTLEKSDFRPVKLIMWWSQPELYIGRGMHESAWSIYKYMMFWIVLLTSKLAFSYYVEQIKPLMGPTKEIMSVPMPGYWLPEFFPHVKNNRGVVITLWSPVILVYFMDTQIWYAIVSTLVGGLYGAFRHIGEIQTLGMLRSRFQSLPGAFNACLIPNENTKEKGIKLAFSRKCHKIPNTNGKEAKQFSQMWNTIINSFREEDLISNRELELLLMSCWAYPDLDFIRWPIFLLASKIPIAVDIAKKRNGKHRELKNILAEDNCMSCAVRECYASIKKLLNTLVTGNSDLMLITTVFTIIDTHIEKDTLLTELNLSVLPDLHGHFVKLTEYVLQNKDKDKIQIVNVLLKILEMVTKDILKEEIKRLHLLLTVKESAMDVPSNLEARRRLTFFSNSLFMEMPGAPKIQNMLSFSALTPYYSEDVLFSTFDLEKENDGVSILFYLQKIFPDEWKNFLERVKCGTEEELDAIDYLKEEIRLWASYRGQTLTKTVRGMMYYQKALELQAFFDLANERELMKGYKSAEASSSGSSLWAECQALADIKFTYVVACQQYSIHKRSGDQRAKDILTLMTTYPSLRVAYIDEVEQTHIYSKGTSENFYYSALVKAAPQTYSTDSSDSGHMLDQVIYQIKLPGPPIIGEGKPENQNNAIIFTRGEALQTIDMNQDYYIEEAFKMRNLLQEFLEKNGGVRYPTILGLREHIFTRSVSCLAWFMSNQEHSFVTIGQRVLANPLKVRFHYGHPDVFDRVFHLTRGGVSKASKVINLSEDIFAGFNSTLREGTVSHHEYIQVGKGRDVGLNQISMFEAKIANGSGEQTLSRDLYRLGHQFDFFRMLSCYFTTVGFYFCSMLTVLTVYVFLYGRLYLVLSGVEKELGNKPMMMEIILASQSFVQIVFLMAMPMIMEIGLERGFYDALFDFVLMQLQLASVFFTFQLGTKFHYYCKTLLHGGAEYRGTGRGFVVFHAKFAENYRFYSRSHFVKATELGILLLVYHIFGPTYIGLFTISIWFMVGTWLFAPFLFNPSGFEWHEIVEDWADWKKWIEYDNGGIGVPPEKSWESWWEKDIEHLQHSGKWGIVVEIFFALRFFIFQYGLVYQLSAFKNKYSSLWVFGASWLLILILLLTVTVLDYARRRLGTEFQLLFRIIKVSLFLAFMAIFITLMTCRLILPQDVFLCMLALIPTGWGLLLIAQSCKPLIQQPGIWSWVMTLAWVYDLVMGSLLFIPIAFMAWFPFISEFQTRMLFNQAFSRGLHISRILSGQRKHRSSKNKD", "length": 1871 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9LU95-1", "protein_name": "Pyruvate kinase", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEMLLGGQATNGALRSKTKIVCTLGPASRSVEMIEKLLKAGMNVARFNFSHGSHSYHQETLDNLRTAMDNTGILCAVMLDTKSPVIRTGFLKEGKPIQLKQGQEITISIDYKIQGDSNTISMSYKKLAEDLKPGDVILCSDGTISLNVLSCDKYLGLVRCRCENSALLGERKNVNLPGIVVDLPTLTEKDKEDIMQWGVPNKIDIIALSFVRKGSDLIQVRKLLGEHSKSIMLMSKVENQEGVMNFDKILENSDAFMVARGDLGMEIPIEKMFLAQKTMINKANAHGKPVVTATQMLESMTVSPRPTRAEATDVANAVLDGTDCVMLSGETAAGAHPETAVLTMSRICKEAEDFIDYDILHKKTLGMVSLPLSPIESLAASAVSTARSVFASAIVVLTRGGYTAELVAKYRPSVPILSVIMPEIAECSDSVAHVARRGLIYRGIIPVVGCSARDSTEEMIRLAIGFAKTKGICKTGDSIVALHKIDGSSIVRIVSVE", "length": 497 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9LX08-1", "protein_name": "Annexin D6", "gene_name": "ANN6", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MASLKIPANIPLPEEDSEQLHKAFKGWGTNEGMIISILAHRNATQRSFIRAVYAANYNKDLLKELDGELSGDFERVVMLWTLDPTERDAYLANESTKLFTKNIWVLVEIACTRPSLEFFKTKQAYHVRYKTSLEEDVAYHTSGNIRKLLVPLVSTFRYDGNADEVNVKLARSEAKTLHKKITEKAYTDEDLIRILTTRSKAQINATLNHFKDKFGSSINKFLKEDSNDDYVQLLKTAIKCLTYPEKYFEKVLRRAINRMGTDEWALTRVVTTRAEVDLERIKEEYLRRNSVPLDRAIANDTSGDYKDMLLALLGHDHA", "length": 318 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9LXS7-1", "protein_name": "Citrate synthase 1, peroxisomal", "gene_name": "CSY1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEISERARARLAVLNAHLTVSEPNQVLPAIEPWCTSAHITAAPHGSLKGNLKIVDERTGNEYQVPVSEHGTVKTVDLKKITTGKDDKGLNLYDPGYLNTAPVRSSISYIDGDEGILRYRGYPVEELAEKSTYTEVTYLLIYGNLPSQRQLADWEFAISQNSAVPQGVLDMIQSMPNDVHPVGALVTAMSALSIFYPDANPSLMGLGVYKSKQVRDKQIVRVLGQAPTIAAAAYLRKAGKPPVQPLSNLSYSENFLYMVESMGDRSYKPNPRLARVLDILFILQAEHEMNCSTAAARHLSSSGGDVYTAVSGGVGAIYGPLHGGAVEATINMLSEIGTVENIPEFIESVKNKKRRLSGFGHRIYKNYDPRGKVVKKLADEVFSILGRDPLVEVGDALEKAALSDEYFVKRKLYPNVDFYSGLINRAMGIPSSFTAVSRIAGYLSHWRESLDDPDTKIMRPQQVYTGAGIRHYETVRERTKL", "length": 480 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9LY06-1", "protein_name": "Glycine/proline-rich protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MITCILKISISSFIVLRIFSFLWFSRWFCCGLCGRFWFRCWFCCWFQFWFRCRFYCRFDTGFDVRFAAGFAADLTIGFTIGFDSGFATFLDVGLDDGFATGLDISFAGGFVTGFATDFDVGFDTGFTIGFDTGFDVGLPAVFSIGFDTGFAVGFAISFTVGFDAGFPTGFFVSLDVGFVADFVIGFATGIGVGFEVDFATDFDTCFATGFAVSFDVGFAGGFSIGFAADFANGFTVGFDGGFDASFFVGLDVGFVVGFVTSFAAGLDVGFAIDFATGFDTGFAFGLAFGFDVGFAAGFAVGFATGFTVVFDVGFASDFFVGLDVGFLTGFATDFDIGFVVDFDIGFATGFVVGFDDGSIVGLVVGLPASLDDGLAIDFVVGLDIGFVTGLFVGLVDGLTTDLDVGLVDGLDDGLDDGLDVDLVVVGFVVDGLAVDLDVGLGVGLTVGFVDGLDVGFDDGLDADTVDGLDVGLDDGLDVDLVDGLDIGLDDGLDVGLDDGLDFGLVDGLDVDLDDGLDVDLVDGLDIGLDDGLDVGLDDGLDFGLVDDGLVVGLFDVFVGTGLSWEIPPPGKLPPDASPLGIGSFGVGPPGASPFIASPSGEGPLSEGLLGIRSFGISPLSIRPLGISPLGISPPNIEPSKADASDADPSNAGPLGISPLSIDPPVAGASDEGPLGKLPPDLSPPGKGSSGEGPLVESPPSEGPLGVDPLGAGSLGISPLGKSPLRIRPLGISPFGKIPSNIDPSSALASDGGPPDEPASAEGSPDVGIFGISPPIIDPPVEGASDGDPPEKLSLDISPLGKGPSGVSLLGAGPPGVGPVIASPPGEGPRDAGPLGAGSLGISPLNIRRLGISPSGISPPNIDLPVAGTSIGGPPDEGASDGGPPDVGPFGISPPIIDPPGESESDGDPAGKLPLDISPLSKGPSCVSPLGVGPVIASPPGEGPLDAGPLGAGSLGISPLNIRRLSISPFGISPSSIDSPVAGTSIGGPPDEGASDGGPPDVGPFGISPPIIDPPGEDASDGDPPGKFPLDISPLGKCPSGVSPLGVGPPGVGPVIASPPGEGPLDAGPLGAGSLGISPLNIRRLGISPFGISPPNIDLPVAGTSIGGPLDEGASDGGPPDVGPFGISPSIIDPPGEGAFDGDPPGKLPLDISPVGKGPSGVSPPGAGPPGDGPVIASPPGESPLDAGPLGAGSLGISPFGISPPNIDWPVAGTSFGGPPGEGASNGGPLVVGPFDMPVVGASDGDALEKLPLDISLPGKGPSDVGPPGAGLPGAAPPGVDLSNVGASDRGASGEGASDGCPPDVGPFDICLLSIDPPVVGASDGGPPDEGASNGGPPDTDSFGGDPLCASPLGIDPPIVDASDGDPFGAGSPDEDPSNENASGEGASGESPPCSDVSCKGPSSAGASIGCSLDNGASTPSSPDTFLSNVFPSDKSSPDAFSPDVAALVTLPSGKDPFDISPPIVALLDVSPLGKTSSDAYSSGISPGIFEKSFPLVKLQTIEYM", "length": 1504 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9M2S0-1", "protein_name": "Probable mannose-1-phosphate guanylyltransferase 2", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKALILVGGFGTRLRPLTLSLPKPLVDFANKPMILHQIEALKAIGVDEVVLAINYEPEQLLVMSKFSNDVEATLGIKITCSQETEPLGTAGPLALARDKLVDGSGQPFFVLNSDVISDYPLEEMIAFHNAHGGEASIMVTKVDEPSKYGVVVMEEATGRVERFVEKPKLFVGNKINAGIYLLNPSVLDRIELRPTSIEKEIFPQIAEAEKLYAMLLPGFWMDIGQPRDYITGLRLYLDSLRKKSPSKLATGPHILGNVLVDETAEIGEGCLIGPNVAIGPGCVVESGVRLSHCTVMRGVHVKRYACISSSIIGWHSTVGQWARVENMSILGKNVYVCDEIYCNGGVVLHNKEIKSDILKPDIVM", "length": 364 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9NR96-1", "protein_name": "Toll-like receptor 9", "gene_name": "TLR9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE", "length": 1032 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QUG3-1", "protein_name": "Prion-like protein doppel", "gene_name": "Prnd", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKNRLGTWWVAILCMLLASHLSTVKARGIKHRFKWNRKVLPSSGGQITEARVAENRPGAFIKQGRKLDIDFGAEGNRYYAANYWQFPDGIYYEGCSEANVTKEMLVTSCVNATQAANQAEFSREKQDSKLHQRVLWRLIKEICSAKHCDFWLERGAALRVAVDQPAMVCLLGFVWFIVK", "length": 179 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9SAC9-1", "protein_name": "AP-1 complex subunit mu-1", "gene_name": "AP1M1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAGAASALFLLDIKGRVLVWRDYRGDVTAAQAERFFTKLIETEGDSQSNDPVAYDNGVTYMFVQHSNIYLMIASRQNCNAASLLFFLHRVVDVFKHYFEELEEESLRDNFVVVYELLDEMMDFGYPQFTEARILSEFIKTDAYRMEVTQRPPMAVTNSVSWRSEGLKFKKNEVFLDVIESVNILVNSNGQIVRSDVVGALKMRTYLSGMPECKLGLNDRILLEAQGRAIKGKAIDLEDIKFHQCVRLARFENDRTISFIPPDGSFDLMTYRLSTQVKPLIWVEAHIERHSRSRVEMLVKARSQFKDRSYATSVEIELPVPTDAYNPDVRTSLGSAAYAPEKDALVWKIQYFYGNKEHTLKADFHLPSIAAEEATPERKAPIRVKFEIPKFIVSGIQVRYLKIIEKSGYQAHPWVRYITMAGEYELRLM", "length": 428 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SCN2-1", "protein_name": "Cytochrome P450 71B31", "gene_name": "CYP71B31", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSMFLGLLFLFPLFFILFKNLLPPRKKLPPGPTGLPLIGNLHQLGRLLHSSLHKLSLEHGPVMLVRWGVVPMAVFSSNEAAKEVLKTHDLETCNRPKLVANGLFTHGYKDIGFTQYGEEWREMKKFVGLELFSPKKHKSFRYIREEEGDLLVKKISNYAQTQTLVDLRKSLFSYTASIIFREAFGQNFRECDYINMDKLEELVQETETNVCSLAFTDFFPRGLGWLVDRISGQHSRMNIAFSKLTTFFEDVIDELLKTKQLDDHSDLVTAMLDVINRPRKFGSLKITYDHLIAMMSDVVLAGVNAGTVTMIWTMTELTRHPRVMKKLQEEIRATLGPNKERITEEDLEKVEYLNLVIKESFRLHPPAPLLLPRETMSDIEIQGYHIPKNAHVKINTYAIGRDPKRWTNPEEFNPERFLNTSINYKGQHYELLPFGAGRRNCPGMTLGITILELGLLNILYYFDWSLPSGMTIKDIDMEEDGALNIAKKVPLQLVPTLP", "length": 498 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SJ39-1", "protein_name": "Cytochrome P450, family 705, subfamily A, polypeptide 6", "gene_name": "CYP705A6", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAAILSVDFQNCFIFIVLCLFSLFCYSLFFKKPKHPRGCDLPPSPPSLPIIGHLHLLFSPLTHKSLQKLSSKYGHLLHLRIFNVPVILVSSASVAYEIFRAHDVNVSSRGVAAIDESLLFGSSGIITAPYGDYWKFMKKLIATKLLRPQSLESSRGIRGEELTRFYNSLLDKARMTESVEISTEAMKLVNNTLCRMSMGRSFSEENGEAEKIRGLVGESYALTKKMFLASLLRKPLKKLRISLFEKEIMGVSDRLDELLERILVEHEEKLHEEHQGTDMMDVLLAASGDENAEYNITRNHIKSFFVEIFIGATDTSVQTTQWTMAEILNHPNVLERLRKDIDSVVGKTRLIHETDLPNLPYLQAVVKEGLRLHPPGPLLVRTFQERCKIKGFYIPEKTTLVINAYAVMRDPDSWEDPDEFKPERFLRAPPMGGSLDKFIEFS", "length": 442 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SMT4-1", "protein_name": "Large ribosomal subunit protein eL13y", "gene_name": "RPL13C", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKHNNVIPNGHFKKKWENYVKTSFNQPAMKTRRRIARQNKAVKIFPRPTAGPIRPVVHAQTLTYNMKVRAGKGFTLEELKAAGIPKKLAPTIGISVDHHRKNRSLEGFQTNVQRLKTYKAKLVIFPRCARTVKVGDSAQQELANATQVQVDHMPIVREMPTMELVKLTSDMKLFNAYDKIRLEGINKRHAGVRAKRAAEAEKEEKK", "length": 206 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SSB4-1", "protein_name": "26S proteasome regulatory subunit 7 homolog B", "gene_name": "RPT1B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MIIRDIMEDPENEGPHNMRSDFEPLLSVLRLRDYETGDIIEFDSTEASEEALSDITEFGSTEASEAHFEEPYSARIKKVEKEINELAEKICNLGIKESDTGLAPPNQWDLVSDKQMMQEEQPLLVATCTQIISPNTEDAKYVVDIKKIGKYVVGLGDKASPTDIEAGMRVGVDQKKYQIQIPLPPKIDPSVTMMTVEEKPDATYSDIGGCKEQIEKIREVVELPMLHPEKFVRLGIDPPKGVLCYGPPGSGKTLVARAVANRTGACFIRVVGSELVQKYIGEGARMVRELFQMARSKKACILFFDEIDAIGGARFDDGVGSDNEVQRTMLEILYQLDGFDARGNIKVLMATNRPDILDPALLRPGRLDRKVEFCLPDLEGRTQIFKIHTRTMSCERDIRFELLAGLCPNSTGADIRSVCIEAGMYAIGARRKSVTEKDFLDAVNKVVKGYQKFSATPKYMAYYI", "length": 464 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SVM4-1", "protein_name": "Serine hydroxymethyltransferase 5", "gene_name": "SHM5", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEPVYSWGNTHLDFVDPEIYDLIEKEKHRQCRGIELIAAENFTSVAVMEALGSCLTNKYSEGMPGNRYYGGTEFIDEIESLCRSRSLEAFHCNPEKWGVNVQPYSGSPANFAAYTALLQPHDRIMGLDLPSGGHITHGYYSSGGKNISATSIYFENLPYKVDSKTGYIDYDKLEEKAMDFRPKLIICGGTSYPREWDYARFRAVADKVGAFLLCDMAHNSALVAAQEAADPFEYCDVVTTSTHKSLRGPRAGMIFYRKGPKPAKKGQPEGEVYDFDAKINSAVFPALQSGPHNNKIGALAVALKQVMAPSFKVYAKQVKANAACLASYLINKGYTLVTDGTDNHLILWDLRPLGLTGNKVEKVCELCYITLNRNAVFGDTSFLAPGGVRIGTPAMTSRGLVEKDFEKIGEFLHRAVTITLDIQEQYGKVMKDFNKGLVNNKEIDEIKADVEEFTYDFDMPGFFISESRND", "length": 470 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SWH4-1", "protein_name": "Syntaxin-42", "gene_name": "SYP42", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATRNRTTVYRKHRDACKSARAPLSLSASDSFGGPVIEMVSGSFSRSNHSSYAPLNSYDPGPSSSDAFTIGMPPAWVDDSEEITFNIQKVRDKMNELAKAHSKALMPTFGDNKGIHREVEMLTHEITDLLRKSEKRLQMLSTRGPSEESNLRKNVQRSLATDLQNLSMELRRKQSTYLKRLQQQKEGQDEVDLEFNVNGKMSRLDEEDELGGMGFDEHQTIKLKEGQHVSAEREREIQQVLGSVNDLAQIMKDLSALVIDQGTIVDRIDYNVQNVSTSVEEGYKQLQKAERTQREGAMVKCATILLVLCLIMIVLLILKNILF", "length": 323 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SYN6-1", "protein_name": "SOUL heme-binding family protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEAALSIFKLSFLLTLLSGGSDLIDSLPPNCNRAECPSYEVVHAGNGYEIHRYNTTVWISTEPIQDISLNEASGNGWNQLSDYMNGNNDYHQRIEIALPYITQVSQNLSTFIVSFFVPKAFQPDPPPGNNLHVQRWDSRYVAVKQISGYVADHKIGKQVAELKASLQGTVWAKAIEKSRETGGVGSAWAYTVAQFSWPFQWSQRVNEIWFPFEMEDEETVSIVTQ", "length": 225 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9SZB4-1", "protein_name": "Putative DEAD-box ATP-dependent RNA helicase 43", "gene_name": "RH43", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEVDDGYVEYVPVEERLAQMKRKVVEEPGKGMMEHLSDKKKLMSVGELARGITYTEPLSTWWKPPLHVRKMSTKQMDLIRKQWHITVNGEDIPPPIKNFMDMKFPSPLLRMLKDKGIMHPTPIQVQGLPVVLSGRDMIGIAFTGSGKTLVFVLPMIILALQEEIMMPIAAGEGPIALVICPSRELAKQTYDVVEQFVASLVEDGYPRLRSLLCIGGVDMRSQLDVVKKGVHIVVATPGRLKDILAKKKMSLDACRLLTLDEADRLVDLGFEDDIRHVFDHFKSQRQTLLFSATMPAKIQIFATSALVKPVTVNVGRAGAANLDVIQEVEYVKQEAKIVYLLECLQKTTPPVLIFCENKADVDDIHEYLLLKGVEAVAIHGGKDQEDRDYAISLFKAGKKDVLVATDVASKGLDFPDIQHVINYDMPGEIENYVHRIGRTGRCGKTGIATTFINKNQSEITLLDLKHLLQEAKQRIPPVLAELNGPMEETETIANASGVKGCAYCGGLGHRILQCPKFEHQKSVAISSSRKDHFGSDGYRGEV", "length": 542 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9T0E0-1", "protein_name": "Putative ATPase, plasma membrane-like", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATGDSLEDIKIEIDDDLEKIPIEEVFKKLRCSREGLSGAEGKERLKIFGPNKLENKKKEHITLRFFALMFKPLSWVIQAAAIMAMLFANGDGRQLFLGIVCLLIVNTIICYLKEDDAANVVAMARAGLSPKTKVLRDGKWSEQEASILVPGDIVSIKPGDIIPCDARLLEGDTLKVDQSALTGEFGPITKGPGEEVFSGTTCKQGEMEAVVIATGVHTFSGTTAHLVDNRTNKVGHFRKVVTEIENLCVISIAIGISIEVIVMYWIQRRNFSDVINNLLVLVIGGIPLAMPTVLYVIMVTGSLRLYRTGTITQRITAIEDMAAIDVLCSDKTGTLTLNKLSVDKNLIKVYSKDVEKEQVLLLAARASRIENRDGIDAAMVGSLADPKEARAGIREVHFNLVDKRTALTYIDGNGDWHRVSKGTPEQILDLCNARDDLRKSVHSAIRNYAERGLKSFAISWFRNTNCNTVFFFPYQLCSEHKYHIVNKLQERHICGLIGDGVDDVPSLKKADVGIAVANATEAARAASDIVLTEPGLSVIIDAVLASRAILQQMKHYTIYAVSITIRVVFGFMFIALIWKFDFSPFMVLAIALLNEETTKAITMDNVTNPSPTPDSLKLKEIFATGVVYGSYMALITVVFFWAAYRTDIFPRTFHVRDLRGNEAEMMCALYLQVSIMSQALFFVIQSRSWFFVERPGELLFLSFVTVQTIATTLAVYASWETARIEGIGWSWAGVIWLYNIIFFFPLDIMKFGIRYILTGKAQSLFDNMVHLVLNSYAKLSNGIYNHTQADHTYSLLEVSTPPSQDLRGVGWV", "length": 813 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9T0H7-1", "protein_name": "Histone H2A.8", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVCNTNILKDVSTKISAFENVRMIMVEGEMFQVARIHKQLKNRVSAHSSVGATDVVYMTSILEYLTTEVLQLAENTSKDLKVKRITPRHLQLAIRGDEELDTLIKGTIIGGSVIPHIH", "length": 118 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VXF6-1", "protein_name": "Calnexin 14D", "gene_name": "Cnx14D", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAWKMLFAILLLLSAAKTGYLAPESENSVEDVQIEPGAIYGDEKFAYKSPVIDAEKFYFADHFDDVEASRKRWVLSQAKKNDIADEIAKYDGIWNWESPQRIFWANDLGLVLKSKAKHAAIAAPFRQPFDFKSNKPLVVQYELTLQEGQDCGGSYLKLLSAGKGTEQLNRFNDKTPYTIMFGPDKCGNNLKMHFIFRHVNPLNGNITEKHCKKPNARLGVPFTDKLPHLYQLVVRPDNSFEIRLDHKIIKEGSLLTDFVPPVNPPAEIDDPNDHKPESWDERKKIPDPNAHKPEDWDEDAPPHLPDTDAVMPNGWLEDEPDMIFDPTAIEPEDWNSEIDGEWEAPLVENPVCKKAPGCGKWKAPLIPNPNYKGKWSAPMIENPNNQGKWAPRKIANPDFFEDLKPFQMTPINAVGLELWSMSSDILFDNLIITDDVELARDFAANSFDIKRLYIDRESFGNKVVELARANRAIWGIVIVAIAVPVAITIFCKFGLGPSRVAAAKKAAAAAAKKTDDPQPDDDLGAEEEEKLEKGKKEEEKKEEEEEEEKEENKEEKKEEEKDDEKEMKDCEEEEDDEEKDDEEKTDERAAGDTNKESTPLSASPKKNQKSYLDNNEDEEDTLKNKEPTPKKRKRKALKE", "length": 639 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9W240-1", "protein_name": "K Homology domain-containing protein", "gene_name": "cg3927", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "METPSELTEKQNQDQPTYQPRLNEVAQKFLADLDAERKRLSAEFPLCALLIDESVDRVYSTGRIPGKEPFADVYQQKPMKIIQKVFVPVNKFPKFNFTGKILGPKGNSLRRLQEETHCKIVIKGRNSMRDRNKEEELRSSGDPRYAHLHKDLFLEVSAVAPPAECYARIAYALAEIRKYLIPDDNDDVWHEQQRELMEMNPKSAKKSNGLNMAPYRSNFDKAIGAIRNRAPKYNNQIRRVTENPREVAYMEEVEYDYDEHLMFCSPVVRL", "length": 270 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9W4G6-1", "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG2861", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDYEIIEFVRRHISHIDISAETRMRYPDPISNNNFDWNSIGLGEQEDAIGQDQQSQALNENANNVSPDVPPSTIAEPTLEPSTIEGNQGQNPRIISSMPDMMPMANSFNPLININQEAGVVINTGINSIDNGLPSTYSEHISQPTNTESTRNMNSSIFDIPSDLDNNSSNESGDEVTQPTAKQSKINANFVCKIESDTNMDKLPTTSNNTNDKPPNNTDSDSDIISISDLIEDLNLDFNQLPITSCDVETHPADTQSNIDANLPYDLISAINMDFVNPANRTYMSAANSTRGTAYKIRKPRTVKRIIKAPSKSNIGKLLREAAKKENAAAGTQRPKKATSTITSSVQNFPNPNNWPACPFPMQNGTMPADEPNDLMPTVSQSLTVPAAQNRPIQTIGKIIKPPVKRTYTKRANKTNNTNIPNKNSTGVIQSNGVAPTIRQGLVEPGGTNILMPWNRQIPMVSVAENPRVQTIDKIIVPPPKRTYKKRVNKTVNTNQSSESAVGDGAPSAPIQSIPKVRKPRGPGKKTAKMVPGQESQQDIPLGVPPNGEAPQTSSQAPVPRVKRAYRKRANNTNNTNILNVNSTGVMESNGGGPTIPNSQQIPNVAVVLNLPIQPIKPKAPRKPRAKKVCNQQPGTDIPFGVSAQGQTAQIKPKPKPRAPRVPKEPKAPKEPKAPKVPKAPRVPKAPRVPKAPRVPKAPRVPKPPKEPKPPKEPKPPKQPKAPRVPKEPKPPKVPKEPKAPRAPRAPRVPKAPKEPKVPKIPKNPRVPKAPRQPKASMNKIQNTVKVPLPIEPVPLETPTYINPINTPVQSTVGEILALGSMPPISPIKFPVLFDEHAAQHTVANSNMPQSSLPTLDIPQLPTRNNKQPSTKSAEDTEILGLGKNKNAMKSDGRIKQGRVSKPSLRFSPSSSSLRPVVRSLSSSSSSSSSWSSCTTCSTCSSCSTCSSSSDSSQSSRSRNRKRRSPKVPIPHKLFESNGEINFQLGQPTRLESPSPPPPVPMQACGTFEEHLTDLTLVRVHAISPLRSPTYDFDFDLPEPMLSEESSSSSSESNDESNVNCQMAPNSQNVSMHFLKVMVFYNCYVLFQQLEKKHQSLFEESSSSSSSESNDETNVNCQMTPNSQNQKKLQSAPIREPSPDQPPEAASRSSNGGTIGPCNLKAFRRDFMISNAENTGFTNPSELNLKKCATKVCTPMERNSGSQLPIQNRFILPNSNKEEGKMNVEPVMPKHKPSRIPIRTKTPIALNLMKEPEDNARKPKNILKPFFSNADVNPCSSTDYEPNFKPCESPLPAKQNDFKLINKDKKSWVSHYQEQESQELKENSFFYAKFNLPNIPKKSFKDSKANAERRCTKTFEDVRKEAQQSRYTKAINKRQNKKAMLESALGNAITEDPTVNCNLADNPNDQVEMPRNPDIVEPTVKPVKFKAFVSASIKPKSSKKRKLMNSASNSKLFKFKIFESEVNKDENEEEDVIPDNLIIPVKRKQNISELLDMQPSTSKAAATITSQPKIAQLKRMPSKLLNEKMKSYAKKRSNDDENKDTKNTGMHMHRYKIPKLSANKPQNTSTTQSPTRGFSRLPGMYQEPNFQNAQHPFSTRGYYPYQRAYPLHRPTSQYHMNQPQPLRLHHSMYVDAEPSFESVFPAPRYQPYNINPSMRHHYSYPGEPSPSTYPMGGIPFQNNNTLYPPMRNDLCYPRGRLNYPVRNLPPMNSQGTYPPNYPQNFLPNYPPSRQFLLSMQRLADINKQIASGSIESVGGFIQMAYAGRKYRTLKDLRERTMLSKDSLRKIFKCMCKIKRPKWRISKFYLYAYWCEISGIPQSSEFGKPLELNAAYRKVISSYAENKFLRMESLMEKTGFGKSKLKRVLKMIGRKRSTKWRLLNYRKPLIHLHRSQDM", "length": 1893 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9W6A5-1", "protein_name": "Green-sensitive opsin-1", "gene_name": "opn1mw1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNGTEGSNFYIPMSNRTGLVRSPYDYTQYYLAEPWKFKALAFYMFLLIIFGFPINVLTLVVTAQHKKLRQPLNYILVNLAFAGTIMVIFGFTVSFYCSLVGYMALGPLGCVMEGFFATLGGQVALWSLVVLAIERYIVVCKPMGSFKFSANHAMAGIAFTWFMACSCAVPPLFGWSRYLPEGMQTSCGPDYYTLNPEYNNESYVMYMFSCHFCIPVTTIFFTYGSLVCTVKAAAAQQQESESTQKAEREVTRMVILMVLGFLFAWVPYASFAAWIFFNRGAAFSAQAMAVPAFFSKTSAVFNPIIYVLLNKQFRSCMLNTLFCGKSPLGDDESSSVSTSKTEVSSVSPA", "length": 349 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9XK79-1", "protein_name": "NADH-ubiquinone oxidoreductase chain 4L", "gene_name": "nad4L", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNLIDLILIAIYVIGISGLIFNKNNIINILIISELNLGTLGMLFVLASVELNDILGELSGLYILTFTAAESAIGLAIVVILYSKTGIINIRHLNKLKG", "length": 98 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9Y2B0-1", "protein_name": "Protein canopy homolog 2", "gene_name": "CNPY2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKGWGWLALLLGALLGTAWARRSQDLHCGACRALVDELEWEIAQVDPKKTIQMGSFRINPDGSQSVVEVPYARSEAHLTELLEEICDRMKEYGEQIDPSTHRKNYVRVVGRNGESSELDLQGIRIDSDISGTLKFACESIVEEYEDELIEFFSREADNVKDKLCSKRTDLCDHALHISHDEL", "length": 182 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z1X0-1", "protein_name": "C-C motif chemokine 27", "gene_name": "Ccl27", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMEGLSPASSLPLLLLLLSPAPEAALPLPSSTSCCTQLYRQPLPSRLLRRIVHMELQEADGDCHLQAVVLHLARRSVCVHPQNRSLARWLERQGKRLQGTVPSLNLVLQKKMYSHPQQQN", "length": 120 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "S4R2L0-1", "protein_name": "Secretoglobin, family 2B, member 12", "gene_name": "Scgb2b12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGILLLLGLLITGELSFQTTEACVPFFEVYASVLSGSRVWLYHELQSFDATAEEKVALEKIQGCYREERLRNILLEPKIMEAMVASPECRSYYSLDNFRSILDFISNLLGE", "length": 112 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "W4VSP8-1", "protein_name": "Vomeronasal type-1 receptor", "gene_name": "Vmn1r10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSFKNVLYFQAGLGVLANMVLLLFYIFIILGHRPKPTDLISCQLTFVHIIMVLTGGDILLTDLFELLNIENDLKCKTIFYISRVMRGLSICTTCLLSVFQAVTISPNTSLMAKFKQKLKKYMACVFLCIWSFNLAFSTNRIFYVGGFTNVSETNQMQVTKSCSLLPMNIIIRGFIFTISTSRDVFLVGVMLTTSVYMVITMFRYHRQCKYLYSISHLRESPEKRATQTIVLLVSFFVVMYWVDFIISFTSDMIWMYDPLILTVQKFMMYAYPTITPLVQISSDNRIIIMLKNLQSKHQQRFFNKDIFFSL", "length": 311 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "X1WF74-1", "protein_name": "Uncharacterized protein LOC100334758 precursor", "gene_name": "si:dkey-52p2.5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MARTSENMIGKVLFVLFLLSGPTSVLTDFHSLQILGTYIKGDTLFPQISFTFMLDDLTVGLYITERDEFIPRDNTTNEDETVSDMLDKIKNELQPLLKGTLIFQNSTESPQLFQIAWHCELLDNNKTGQMILKIAFSGSTTDEVSFYGNNFTCQCQNNMATVPLEYFQMQFKSIYYPVCMTTLGGYLVKRQVQVNRKVQPKVRLIKKVHPKSGGFRLSCLASEFYPYFINLTLLRDGQPVSDHEVTGGDLLPNGDGTYQMRKSLEIRADEREKHKYTCSAKHLDKNLDVDFEFDPSYPVKIVIPVVVLLSLVLVLTAVLIHKCMNKQAASPPEQQEPIEMGGRLRK", "length": 346 }, "evidence": [ { "id": "A0A3Q1M0W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M0W3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "keratinization", "id": "GO:0031424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031424", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W3" } ], "pmid": "" }, { "name": "intermediate filament organization", "id": "GO:0045109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045109", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of skin epidermis", "id": "GO:0030280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030280", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0W3" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 123, "end_pos": 434, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"uniprot_ac": "A0A3Q1M0X3", "uniprot_id": "A0A3Q1M0X3_BOVIN", "mass": { "chemical_mass": 88475.0, "monoisotopic_mass": 88475.0 }, "refseq": { "ac": "XP_024835702", "name": "spermatogenesis-associated protein 20 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835702" }, "gene_names": [ { "name": "SPATA20", "type": "recommended", "evidence": [ { "id": "A0A3Q1M0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X3" } ] }, { "name": "SPATA20", "type": "synonym", "evidence": [ { "id": "XP_024835702", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835702" } ] } ], "protein_names": [ { "name": "Spermatogenesis-associated protein 20", "type": "recommended", "evidence": [ { "id": "A0A3Q1M0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X3/entry#names_and_taxonomy" } ] }, { "name": "spermatogenesis-associated protein 20 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024835702", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835702" } ] } ], "function": [ { "annotation": "May play a role in fertility regulation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Y0#function" }, { "database": "UniProtKB", "id": "PIRNR006402", "url": "https://www.uniprot.org/uniprotkb/PIRNR006402#function" }, { "database": "UniProtKB", "id": "A0AAA9TN67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN67#function" }, { "database": "UniProtKB", "id": "A0A3Q1M0X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPATA20", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X3", "locus": { "chromosome": "19", "start_pos": 36171019, "end_pos": 36179221, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004155", "url": "https://www.ensembl.org/id/ENSBTAG00000004155" } ] } } ], "crossref": [ { "id": "A0A3Q1M0X3", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0X3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004155", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004155", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02955", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02955", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511363", "url": "https://www.ncbi.nlm.nih.gov/gene/511363", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008928", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008928", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0X3", "url": "https://www.orthodb.org/?gene=A0A3Q1M0X3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42899", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42899", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42899:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42899:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03190", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03190", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024835702", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835702", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0X3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6Y0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Y0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Y0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN67-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHLSSPPQKHKGEHKGHGLPRGSERGSSARDKDRSVTVSSSVPMPAGGKGSRTNCSQSTPQKVPNRLINEKSPYLLQHAYNPVDWYPWGQEAFDKAKKENKPIFLSVGYSTCHWCHMMEEESFQNEEIGRLLSEDFVSVKVDREERPDVDKVYMTFVQATSSGGGWPMSVWLTPDLQPFVGGTYFPPEDGLTRVGFRTVLMRIRDQWKQNKSTLLENSQRVTTALLARSAISMGDRQLPPSAATMNSRCFQQLDEGYDEEYGGFAEAPKFPTPVILSFLFSYWLSHRLTQDGSRAQQMALHTLKMMANGGIRDHVGQGFHRYSTDRQWHVPHFEKMLYDQAQLTVAYSQAFQISGDEFYSEVAKGILQYVVRNLSHRSGGFYSAEDADSPPERGMRPKEGAFYVWTVKEVQHLLPEPVLGATEPLTSGQLLMKHYGLTEAGNISPSQDPKGELQGQNVLTVRYSLELTAARFGLDVEAVRTLLNSGLEKLFQARKHRPKPHLDSKMLAAWNGLMVSGFAVTGAVLGQERVINYAINGAKFLKRHMFDVASGRLMRTCYAGSGGTVEHSNPPCWGFLEDYAFVVRGLLDLYEASQESAWLEWALRLQDTQDRLFWDSRGGGYFCSEAELGAGLPLRLKDDQDGAEPSANSVSAHNLLRLHGFTGHKDWMDKCVCLLTAFSERMRRVPVALPEMVRALSAHQQTLKQIVICGDPQAKDTKALLQCVHSIYIPNKVLILADGDPSSFLSRQLPFLNTLRRLEDRATAYVCENQACSMPITEPCELRKVLHQ", "length": 789, "header": "tr|A0A3Q1M0X3-1|A0A3Q1M0X3_BOVIN Isoform 1 of Spermatogenesis-associated protein 20 OS=Bos taurus OX=9913 GN=SPATA20 PE=4 SV=1 CANONICAL=A0A3Q1M0X3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0X3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X3/entry", "sequence": { "sequence": "MSHLSSPPQKHKGEHKGHGLPRGSERGSSARDKDRSVTVSSSVPMPAGGKGSRTNCSQSTPQKVPNRLINEKSPYLLQHAYNPVDWYPWGQEAFDKAKKENKPIFLSVGYSTCHWCHMMEEESFQNEEIGRLLSEDFVSVKVDREERPDVDKVYMTFVQATSSGGGWPMSVWLTPDLQPFVGGTYFPPEDGLTRVGFRTVLMRIRDQWKQNKSTLLENSQRVTTALLARSAISMGDRQLPPSAATMNSRCFQQLDEGYDEEYGGFAEAPKFPTPVILSFLFSYWLSHRLTQDGSRAQQMALHTLKMMANGGIRDHVGQGFHRYSTDRQWHVPHFEKMLYDQAQLTVAYSQAFQISGDEFYSEVAKGILQYVVRNLSHRSGGFYSAEDADSPPERGMRPKEGAFYVWTVKEVQHLLPEPVLGATEPLTSGQLLMKHYGLTEAGNISPSQDPKGELQGQNVLTVRYSLELTAARFGLDVEAVRTLLNSGLEKLFQARKHRPKPHLDSKMLAAWNGLMVSGFAVTGAVLGQERVINYAINGAKFLKRHMFDVASGRLMRTCYAGSGGTVEHSNPPCWGFLEDYAFVVRGLLDLYEASQESAWLEWALRLQDTQDRLFWDSRGGGYFCSEAELGAGLPLRLKDDQDGAEPSANSVSAHNLLRLHGFTGHKDWMDKCVCLLTAFSERMRRVPVALPEMVRALSAHQQTLKQIVICGDPQAKDTKALLQCVHSIYIPNKVLILADGDPSSFLSRQLPFLNTLRRLEDRATAYVCENQACSMPITEPCELRKVLHQ", "length": 789, "header": "tr|A0A3Q1M0X3-1|A0A3Q1M0X3_BOVIN Isoform 1 of Spermatogenesis-associated protein 20 OS=Bos taurus OX=9913 GN=SPATA20 PE=4 SV=1 CANONICAL=A0A3Q1M0X3-1" }, "locus": { "chromosome": "19", "start_pos": 36178164, "end_pos": 36171209, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070783.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070783.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063643.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063643.1" } ] } }, { "isoform_ac": "A0AAA9S6Y0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Y0/entry", "sequence": { "sequence": "MLGARALRCRGFLLPGAGPVLALSYRGSSARDKDRSVTVSSSVPMPAGGKGSRTNCSQSTPQKVPNRLINEKSPYLLQHAYNPVDWYPWGQEAFDKAKKENKPIFLSVGYSTCHWCHMMEEESFQNEEIGRLLSEDFVSVKVDREERPDVDKVYMTFVQATSSGGGWPMSVWLTPDLQPFVGGTYFPPEDGLTRVGFRTVLMRIRDQWKQNKSTLLENSQRVTTALLARSAISMGDRQLPPSAATMNSRCFQQLDEGYDEEYGGFAEAPKFPTPVILSFLFSYWLSHRLTQDGSRAQQMALHTLKMMANGGIRDHVGQISGDEFYSEVAKGILQYVVRNLSHRSGGFYSAEDADSPPERGMRPKEGAFYVWTVKEVQHLLPEPVLGATEPLTSGQLLMKHYGLTEAGNISPSQDPKGELQGQNVLTVRYSLELTAARFGLDVEAVRTLLNSGLEKLFQARKHRPKPHLDSKMLAAWNGLMVSGFAVTGAVLGQERVINYAINGAKFLKRHMFDVASGRLMRTCYAGSGGTVEHSNPPCWGFLEDYAFVVRGLLDLYEASQESAWLEWALRLQDTQDRLFWDSRGGGYFCSEAELGAGLPLRLKDDQDGAEPSANSVSAHNLLRLHGFTGHKDWMDKCVCLLTAFSERMRRVPVALPEMVRALSAHQQTLKQIVICGDPQAKDTKALLQCVHSIYIPNKVLILADGDPSSFLSRQLPFLNTLRRLEDRATAYVCENQACSMPITEPCELRKVLHQ", "length": 754, "header": "tr|A0AAA9S6Y0-1|A0A3Q1M0X3_BOVIN Computationally mapped isoform of Spermatogenesis-associated protein 20 OS=Bos taurus OX=9913 GN=SPATA20 PE=4 SV=1 CANONICAL=A0A3Q1M0X3-1" }, "locus": { "chromosome": "19", "start_pos": 36178983, "end_pos": 36171209, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103462.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103462.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079667.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079667.1" } ] } }, { "isoform_ac": "A0AAA9TN67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN67/entry", "sequence": { "sequence": "MSHLSSPPQKHKGEHKGHGLPRGSERGSSARDKDRSVTVSSSVPMPAGGKGSRTNCSQSTPQKVPNRLINEKSPYLLQHAYNPVDWYPWGQEAFDKAKKENKPIFLSVGYSTCHWCHMMEEESFQNEEIGRLLSEDFVSVKVDREERPDVDKVYMTFVQATSSGGGWPMSVWLTPDLQPFVGGTYFPPEDGLTRVGFRTVLMRIRDQWKQNKSTLLENSQRVTTALLARSAISMGDRQLPPSAATMNSRCFQQLDEGYDEEYGGFAEAPKFPTPVILSFLFSYWLSHRLTQDGSRAQQMALHTLKMMANGGIRDHVGQGFHRYSTDRQWHVPHFEKMLYDQAQLTVAYSQAFQISGDEFYSEVAKGILQYVVRNLSHRSGGFYSAEDADSPPERGMRPKEGAFYVWTVKEVQHLLPEPVLGATEPLTSGQLLMKHYGLTEAGNISPSQDPKGELQGQNVLTVRYSLELTAARFGLDVEAVRTLLNSGLEKLFQARKHRPKPHLDSKMLAAWNGLMVSGFAVTGAVLGQERVINYAINGAKFLKRHMFDVASGRLMRTCYAGSGGTVEHSNPPCWGFLEDYAFVVRGLLDLYEASQESAWLEWALRLQDTQDRLFWDSRGGGYFCSEAELGAGLPLRLKDDQDGAEPSANSVSAHNLLRLHGFTGHKDWMDKCVCLLTAFSERMRRVPVALPEMVRALSAHQQTLKQIVICGDPQAKDTKALLQCVHSIYIPNKVWSLSPAPLSASPARDPSLLQLPSISGSSEGLEKKPTSGSCWCLGGPG", "length": 781, "header": "tr|A0AAA9TN67-1|A0A3Q1M0X3_BOVIN Computationally mapped isoform of Spermatogenesis-associated protein 20 OS=Bos taurus OX=9913 GN=SPATA20 PE=4 SV=1 CANONICAL=A0A3Q1M0X3-1" }, "locus": { "chromosome": "19", "start_pos": 36178164, "end_pos": 36171397, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132589.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132589.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099958.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099958.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X3" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X3" } ], "pmid": "" }, { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 374, "end_pos": 376, "annotation": "n_glycosylation_sequon" }, { "start_pos": 443, "end_pos": 445, "annotation": "n_glycosylation_sequon" }, { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M0X3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 789, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M0X3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0X3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0X3" }, { "id": "PF03190", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03190" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Spermatogenesis-associated protein 20-like TRX", "eco_id": "ECO_0000259", "start_pos": 65, "end_pos": 226, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 211, "end_pos": 213 }, { "start_pos": 374, "end_pos": 376 }, { "start_pos": 443, "end_pos": 445 }, { "start_pos": 55, "end_pos": 57 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 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"A0A3Q1M0Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Y1/entry#names_and_taxonomy" } ] }, { "name": "GDNF receptor alpha-2", "type": "synonym", "evidence": [ { "id": "A0A3Q1M0Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Y1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0Y1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Y1#function" }, { "database": "UniProtKB", "id": "PIRNR038071", "url": "https://www.uniprot.org/uniprotkb/PIRNR038071#function" }, { "database": "UniProtKB", "id": "F1MF66", "url": "https://www.uniprot.org/uniprotkb/F1MF66#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0Y1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Y1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GFRA2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Y1", "locus": { "chromosome": "8", "start_pos": 68996147, "end_pos": 69102300, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020665", "url": "https://www.ensembl.org/id/ENSBTAG00000020665" } ] } } ], "crossref": [ { "id": "A0A3Q1M0Y1", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0Y1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020665", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020665", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514036", "url": "https://www.ncbi.nlm.nih.gov/gene/514036", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037193", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037193", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514036", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514036", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LCYSEAQ", "url": "https://omabrowser.org/oma/group/LCYSEAQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0Y1", "url": "https://www.orthodb.org/?gene=A0A3Q1M0Y1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NKH1", "url": "https://www.orthodb.org/?gene=A0A3Q1NKH1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MF66", "url": "https://www.orthodb.org/?gene=F1MF66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10269", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10269", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10269:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10269:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02351", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02351", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5673001", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8853659", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8853659", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001015595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015595", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0Y1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Y1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0Y1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Y1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKH1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKH1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3U9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3U9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF66", "url": "https://www.uniprot.org/uniprotkb/F1MF66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF66-1", "url": "https://www.uniprot.org/uniprotkb/F1MF66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MILANAFCLFFFLDETLRSLASPSSPQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTARLSDIFRLASIFSGTGADPAVSTKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRSLCRTDHLCRSRLADFHANCRASYQTLTSCPTDNYQACLGSYAGMIGFDITPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLKDFTENPCLRNAIQAFGNGTDVNLSPKSPPFQATQAPRVDKTPSLPDDLSDSTSLGTSVISTCTSVQDQGLKANNSQELSMCFTELTTNIIPGSKRVIKPNSGPRRTRPSAALTAASFLMLKLAL", "length": 464, "header": "tr|A0A3Q1M0Y1-1|A0A3Q1M0Y1_BOVIN Isoform 1 of GDNF family receptor alpha-2 OS=Bos taurus OX=9913 GN=GFRA2 PE=3 SV=1 CANONICAL=A0A3Q1M0Y1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0Y1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Y1/entry", "sequence": { "sequence": "MILANAFCLFFFLDETLRSLASPSSPQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTARLSDIFRLASIFSGTGADPAVSTKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRSLCRTDHLCRSRLADFHANCRASYQTLTSCPTDNYQACLGSYAGMIGFDITPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLKDFTENPCLRNAIQAFGNGTDVNLSPKSPPFQATQAPRVDKTPSLPDDLSDSTSLGTSVISTCTSVQDQGLKANNSQELSMCFTELTTNIIPGSKRVIKPNSGPRRTRPSAALTAASFLMLKLAL", "length": 464, "header": "tr|A0A3Q1M0Y1-1|A0A3Q1M0Y1_BOVIN Isoform 1 of GDNF family receptor alpha-2 OS=Bos taurus OX=9913 GN=GFRA2 PE=3 SV=1 CANONICAL=A0A3Q1M0Y1-1" }, "locus": { "chromosome": "8", "start_pos": 69101777, "end_pos": 68996261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081398.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081398.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063328.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063328.1" } ] } }, { "isoform_ac": "A0A3Q1NKH1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKH1/entry", "sequence": { "sequence": "MILANAFCLFFFLGEEFYEASPYEPVTARLSDIFRLASIFSGTGADPAVSTKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRSLCRTDHLCRSRLADFHANCRASYQTLTSCPTDNYQACLGSYAGMIGFDITPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLKDFTENPCLRNAIQAFGNGTDVNLSPKSPPFQATQAPRVDKTPSLPDDLSDSTSLGTSVISTCTSVQDQGLKANNSQELSMCFTELTTNIIPGSKRVIKPNSGPRRTRPSAALTAASFLMLKLAL", "length": 359, "header": "tr|A0A3Q1NKH1-1|A0A3Q1M0Y1_BOVIN Computationally mapped isoform of GDNF family receptor alpha-2 OS=Bos taurus OX=9913 GN=GFRA2 PE=3 SV=2 CANONICAL=A0A3Q1M0Y1-1" }, "locus": { "chromosome": "8", "start_pos": 69101777, "end_pos": 68996261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067017.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067017.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072833.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072833.2" } ] } }, { "isoform_ac": "A0AAA9S3U9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3U9/entry", "sequence": { "sequence": "MILANAFCLFFFLGTGADPAVSTKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRSLCRTDHLCRSRLADFHANCRASYQTLTSCPTDNYQACLGSYAGMIGFDITPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLKDFTENPCLRNAIQAFGNGTDVNLSPKSPPFQATQAPRVDKTPSLPDDLSDSTSLGTSVISTCTSVQDQGLKANNSQELSMCFTELTTNIIPGSKRVIKPNSGPRRTRPSAALTAASFLMLKLAL", "length": 331, "header": "tr|A0AAA9S3U9-1|A0A3Q1M0Y1_BOVIN Computationally mapped isoform of GDNF family receptor alpha-2 OS=Bos taurus OX=9913 GN=GFRA2 PE=3 SV=1 CANONICAL=A0A3Q1M0Y1-1" }, "locus": { "chromosome": "8", "start_pos": 69101777, "end_pos": 68996261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088180.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088180.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076786.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076786.1" } ] } }, { "isoform_ac": "F1MF66-1", "url": "https://www.uniprot.org/uniprotkb/F1MF66/entry", "sequence": { "sequence": "MREKETETERDETLRSLASPSSPQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTARLSDIFRLASIFSGTGADPAVSTKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRSLCRTDHLCRSRLADFHANCRASYQTLTSCPTDNYQACLGSYAGMIGFDITPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLKDFTENPCLRNAIQAFGNGTDVNLSPKSPPFQATQAPRVDKTPSLPDDLSDSTSLGTSVISTCTSVQDQGLKANNSQELSMCFTELTTNIIPGSKRVIKPNSGPRRTRPSAALTAASFLMLKLAL", "length": 461, "header": "tr|F1MF66-1|F1MF66_BOVIN Computationally mapped isoform of GDNF family receptor alpha-2 OS=Bos taurus OX=9913 GN=GFRA2 PE=3 SV=4 CANONICAL=A0A3Q1M0Y1-1" }, "locus": { "chromosome": "8", "start_pos": 69097631, "end_pos": 68996261, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027545.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027545.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027545.7", "url": "https://www.ensembl.org/id/ENSBTAP00000027545.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 357, "start_aa": "Asn", "end_pos": 357, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn357", "evidence": [ { "id": "A0A3Q1M0Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Y1#ptm_processing" }, { "id": "PIRSR038071-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038071-2" } ], "filter_code": "001000000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 413, "start_aa": "Asn", "end_pos": 413, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn413", "evidence": [ { "id": "A0A3Q1M0Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Y1#ptm_processing" }, { "id": "PIRSR038071-2", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR038071-2" } ], "filter_code": "001000000000000000000.00010000000000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:514036", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514036", "resource": "KEGG Pathway" }, { "id": "R-BTA-5673001", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5673001", "resource": "Reactome", "description": "RAF/MAP kinase cascade" }, { "id": "R-BTA-8853659", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8853659", "resource": "Reactome", "description": "RET signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RMZ6-1", "protein_name": "GDNF family receptor alpha-2", "gene_name": "GFRA2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MILANAFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTARLSDIFRLASIFSGTGADPAVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNRQISPTERCNRRKCHKALRQFFDRVPGEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRTLCRIDHLCRSRLADFHANCRASYQTLTSCPTDNYQACLGSYAGMIGFEITPNYVDSSPAGIVVSPWCSCRGSGNLEEECEKFLRDFTENPCLRNAIQAFGNGTDVNLSPKNPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKTNSSKELSMCFTELTTNIIPGSNKVIRPNSGPRRARPSAALTAVSFLMLKLAL", "length": 464 }, "evidence": [ { "id": "A0A3Q1M0Y1", "url": "https://omabrowser.org/oma/group/A0A3Q1M0Y1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O00451-1", "protein_name": "GDNF family receptor alpha-2", "gene_name": "GFRA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL", "length": 464 }, "evidence": [ { "id": "A0A3Q1M0Y1", "url": "https://omabrowser.org/oma/group/A0A3Q1M0Y1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O08842-1", 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"MILANAFCLFFFLDETLRSLASPSSLQGSELHGWRPQVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGTDPAVSTKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRSLCRTDHLCRSRLADFHANCRASYRTITSCPADNYQACLGSYAGMIGFDMTPNYVDSNPTGIVVSPWCNCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNMSPKGPSLPATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSIQEQGLKANNSKELSMCFTELTTNISPGSKKVIKLNSGSSRARLSAALTALPLLMLTLAL", "length": 464 }, "evidence": [ { "id": "A0A3Q1M0Y1", "url": "https://omabrowser.org/oma/group/A0A3Q1M0Y1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0Y1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Y1" } ], "pmid": "" }, { "name": 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"https://www.uniprot.org/uniprotkb/A0A3Q1M0Y5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1125, "end_pos": 1127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 923, "end_pos": 925, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M0Y5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1156, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M0Y5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0Y5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M0Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Y5" }, { "id": "PF23317", 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[ "Protein Classification" ] }, { "id": "PTHR23082:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23082:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-76061", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76061", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-76066", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76066", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M0Z5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Z5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0Z5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Z5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8U7", "url": 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"MSGFSPELIDYLEGKISFEEFERRREERKTREKKSLQEKGKSSVEENPNDSEVPSSSGINSTKSQGKDANEGETSDGVSKSVHKVFASMLGENEDEEEEEEEEEEEEEEETPEQPTAGDVFVLEMVLNRETKKMMKEKRPRSKLPRALRGLMGEANIRFARGEREEAILMCMEIIRQAPLAYEPFSTLAMIYEDQGDMEKSLQFELIAAHLNPSDTEEWVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLWERSSLYEQMGDHKMAMDGYRRILNLLSPSDGERFMQLTRDMAKSYYEANDVTSAISIIEEALSKHQGLVSMEDVNIAAELYISNKQYDRALEVITDFSGIVLEKRTTEEGTSEENKGGDNVICAIPDGVPIDITVKLMVCLVHLNILEPLNPLLTTLVEQNPEDMGDLYLDVAEAFLDVGEYNSALPLLSALVCSERYNLAVVWLRHAECLKALGYMERAAESYSKVVDLAPLHLDARISLSTLQQQLGRPEKALEALEPMYDPDTLAQDANAAQQELKLLLQRSTLLFSQGKMYGYVDTLLTMLAMLLKVAMNRAQVCLISSSKSGERHLYLIKVSRDKISDNNDQESANCDAKAIFAVLTSVLTKDDWWNLLLKAIYSLCDLSRFQEAELLVDSSLEYCSFYEDKPKRKELEYFGLSAAILDKNFRKAYNYIRIMVMENVNKPQLWNIFNQVTMHSQEVRHHRFCLRLMLKNPDNHALCVLNGHNAFVSGSFKHALGQYVQAFRTHPQEPLYNLCIGLTFIHMASQKYVLKRHALIVQGFSFLNRYLSLRGPCQETFYNLGRALHQLGLQHLAIHYYQKALELPPLVVELYRATFFIDADVLS", "length": 859, "header": "tr|E1BPR9-1|A0A3Q1M0Z5_BOVIN Computationally mapped isoform of Ral transcription factor IIIC subunit 3 OS=Bos taurus OX=9913 GN=GTF3C3 PE=4 SV=4 CANONICAL=A0A3Q1M0Z5-1" }, "locus": { "chromosome": "2", "start_pos": 85392927, "end_pos": 85362771, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010228.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010228.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010228.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010228.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-76061", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76061", "resource": "Reactome", "description": "RNA Polymerase III Transcription Initiation From Type 1 Promoter" }, { "id": "R-BTA-76066", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76066", "resource": "Reactome", "description": "RNA Polymerase III Transcription Initiation From Type 2 Promoter" } ], "orthologs": [], "go_annotation": { "categories": [ { 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"https://www.uniprot.org/uniprotkb/A0A3Q1M0Z5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "transcription by RNA polymerase III", "id": "GO:0006383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006383", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0Z5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Z5" } ], "pmid": "" }, { "name": "transcription initiation at RNA polymerase III promoter", "id": "GO:0006384", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006384", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0Z5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Z5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "RNA polymerase III general transcription initiation factor activity", "id": "GO:0000995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000995", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0Z5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Z5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" }, { "start_pos": 60, "end_pos": 62, "annotation": "n_glycosylation_sequon" }, { "start_pos": 871, "end_pos": 873, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M0Z5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 895, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M0Z5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M0Z5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], 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[provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377464" }, "gene_names": [ { "name": "OR6C5H", "type": "recommended", "evidence": [ { "id": "A0A3Q1M108", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M108" } ] }, { "name": "OR6C5H", "type": "synonym", "evidence": [ { "id": "NP_001377464", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377464" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0A3Q1M108", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M108/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 6 subfamily C member 5H", "type": "synonym", "evidence": [ { "id": "NP_001377464", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377464" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377464" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M108", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M108#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M108", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M108" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR6C5H", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M108", "locus": { "chromosome": "5", "start_pos": 58765574, "end_pos": 58766512, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000065800", "url": "https://www.ensembl.org/id/ENSBTAG00000065800" } ] } } ], "crossref": [ { "id": "A0A3Q1M108", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M108", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15912", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15912", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "788027", "url": "https://www.ncbi.nlm.nih.gov/gene/788027", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788027", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788027", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WFLEMIG", "url": "https://omabrowser.org/oma/group/WFLEMIG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M108", "url": "https://www.orthodb.org/?gene=A0A3Q1M108", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26454", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26454", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26454:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26454:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377464", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M108", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M108", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M108-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M108-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRNHTMLTEFVLLGISDNPELQVVIFIFLFLAYVLSVVGNLTIIILTLTDCSLKTPMYYFLRNFSFLEITFTSVSIPRFLGAIITKVKTISYNNCLAQLFFFIFMGVSEFFLLTAMSYDRYVAICEPLHYTTIMNKKICTLLVFSSWLGGFLTIFPPLMPILQLDFCASNIIDHFSCDYCPIWQISCSDTWLLEMIGFYFAFVTLLFTLALVILSYMCIITTILRIPSATQRKKSFSTCSSHMIVISISYGSCIFMYVKPSAKERASLTKGVAILNTSIAPMLNPFIYTLRNEHVKQALKNLVHKVILSRNK", "length": 312, "header": "tr|A0A3Q1M108-1|A0A3Q1M108_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6C5H PE=3 SV=1 CANONICAL=A0A3Q1M108-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M108-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M108/entry", "sequence": { "sequence": "MRNHTMLTEFVLLGISDNPELQVVIFIFLFLAYVLSVVGNLTIIILTLTDCSLKTPMYYFLRNFSFLEITFTSVSIPRFLGAIITKVKTISYNNCLAQLFFFIFMGVSEFFLLTAMSYDRYVAICEPLHYTTIMNKKICTLLVFSSWLGGFLTIFPPLMPILQLDFCASNIIDHFSCDYCPIWQISCSDTWLLEMIGFYFAFVTLLFTLALVILSYMCIITTILRIPSATQRKKSFSTCSSHMIVISISYGSCIFMYVKPSAKERASLTKGVAILNTSIAPMLNPFIYTLRNEHVKQALKNLVHKVILSRNK", "length": 312, "header": "tr|A0A3Q1M108-1|A0A3Q1M108_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6C5H PE=3 SV=1 CANONICAL=A0A3Q1M108-1" }, "locus": { "chromosome": "5", "start_pos": 58766512, "end_pos": 58765577, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079356.1", "url": "https://www.ensembl.org/id/ENSBTAT00000079356.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061701.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061701.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:788027", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788027", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LRV6-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100767709", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRNHSMITEFVLLGISDTPDLQVAIFIFLFIAYILSVCGNLSIITLTLLDSQLKTPMYFFLRNFSFLEIIFTSVSIPRFLESIITQVKTISYNNCLAQLFFFISMGVSEFFLLTAMSYDRYVAICKPLHYTTIMNQRVCTLLVLTSWLGGFLIMFPLIMLFLKLDFCASNVIDHFCCDYFPILQLSCSDTKSLETIGFYFAFVTLLFTLALVILSYICIISTILRFPSASQRKKAFSTCSSHMIVISISYGSCIFMYVKPSANERASLTKGVAVLNTSIAPMLNPFIYTLRNQQVKQAFKDLINKVRSDRNK", "length": 312 }, "evidence": [ { "id": "A0A3Q1M108", "url": "https://omabrowser.org/oma/group/A0A3Q1M108/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8I6AMX2-1", "protein_name": "Olfactory receptor", "gene_name": "Olr906", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRNHSRITDFVLLGISDTPEVQILIFILLFIAYILSVTGNLTIIILTLLDSQLKTPMYFFLQNFSFLEIIFTSVSIPRFLESIITKVKTISYNNCLAQLYFFLSLGVSEFFLLTAMSYDRYVAICKPLHYVIIMNQKVCTLLVLTSWLAGFLSIFPLIMLILKLDFCASNTIDHFSCDYSPILQLSCSDTKHLEAFGLYCASITLLFTLALVILSYICIISTILKFPSASQRKKAFSTCSSHMIVISISYGSCIFMYVKPSANERASLTKGVAVLNTSIAPMLNPFIYTLRNQQVKQAFKDLINRVMFNRKK", "length": 312 }, "evidence": [ { "id": "A0A3Q1M108", "url": "https://omabrowser.org/oma/group/A0A3Q1M108/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TRI5-1", "protein_name": "Olfactory receptor", "gene_name": "Or6c5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKNHSVITEFLLLGISDTPELQFVIFIFLFIAYILSVTGNLTIIILTLLDSQLKTPMYFFLRNFSFLEIIFTSVSIPRFLESIITKVKTISYNNCLAQLFFFISMGVSEFFLLTAMSYDRYVAICKPLHYTLIMNQKVCTLLVLTSWLGGFLTIFPLLMLFLKLDFCASNVIDHFCCDYFPILQLSCSDTWFLETIGFYFAFITLLFTLALVILSYICIINTILRFPSASQRKKAFSTCSSHMIVISISYGSCIFMYVKPSANERASLTKGVALLNTSIAPMLNPFIYTLRNQQVKQAFKDLINKLMFNRNK", "length": 312 }, "evidence": [ { "id": "A0A3Q1M108", "url": "https://omabrowser.org/oma/group/A0A3Q1M108/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M108", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M108" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M108", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M108" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M108", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M108" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M108-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 312, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M108-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M108" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M108", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M108" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 276, "end_pos": 278 }, { "start_pos": 3, "end_pos": 5 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 63, "end_pos": 65 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M132-1", "uniprot_ac": "A0A3Q1M132", "uniprot_id": "A0A3Q1M132_BOVIN", "mass": { "chemical_mass": 18231.0, "monoisotopic_mass": 18231.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Cytochrome c oxidase subunit 5A, mitochondrial", "type": "recommended", "evidence": [ { "id": "A0A3Q1M132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M132/entry#names_and_taxonomy" } ] }, { "name": "Cytochrome c oxidase polypeptide Va", "type": "synonym", "evidence": [ { "id": "A0A3Q1M132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M132/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M132", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M132#function" }, { "database": "UniProtKB", "id": "RU368103", "url": "https://www.uniprot.org/uniprotkb/RU368103#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M132", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M132" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M132", "locus": {} } ], "crossref": [ { "id": "A0A3Q1M132", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M132", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000053121", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000053121", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00923", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00923", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003204", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003204", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14200", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14200", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14200:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14200:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02284", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02284", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M132", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M132", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M132-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M132-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSLKPTFSLSTFTFKRLLNSSSLSAIRVVSSACLRLLIFLLAILIPPSRAPAPCPPAAIQSIHCYFHRSQETDEECDTRWVTYFKTSDVDAQELRKGKNILAGYDLVPEPKITVAGFTVHIIEVIKSKAGPHKEIYPCVIQELRPTLNELGISSPEELGLHKV", "length": 164, "header": "tr|A0A3Q1M132-1|A0A3Q1M132_BOVIN Isoform 1 of Cytochrome c oxidase subunit 5A, mitochondrial OS=Bos taurus OX=9913 GN= PE=3 SV=3 CANONICAL=A0A3Q1M132-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M132-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M132/entry", "sequence": { "sequence": "MLSLKPTFSLSTFTFKRLLNSSSLSAIRVVSSACLRLLIFLLAILIPPSRAPAPCPPAAIQSIHCYFHRSQETDEECDTRWVTYFKTSDVDAQELRKGKNILAGYDLVPEPKITVAGFTVHIIEVIKSKAGPHKEIYPCVIQELRPTLNELGISSPEELGLHKV", "length": 164, "header": "tr|A0A3Q1M132-1|A0A3Q1M132_BOVIN Isoform 1 of Cytochrome c oxidase subunit 5A, mitochondrial OS=Bos taurus OX=9913 GN= PE=3 SV=3 CANONICAL=A0A3Q1M132-1" }, "locus": { "chromosome": "18", "start_pos": 2213700, "end_pos": 2212753, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077429.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077429.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066967.3", "url": "https://www.ensembl.org/id/ENSBTAP00000066967.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M132", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M132" } ], "pmid": "" }, { "name": "respiratory chain complex IV", "id": "GO:0045277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045277", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M132", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M132" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M132", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M132" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mitochondrial electron transport, cytochrome c to oxygen", "id": "GO:0006123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006123", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M132", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M132" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M132-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 164, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M132-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M132" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 20, "end_pos": 22 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q9N285-1", "uniprot_ac": "Q9N285", "uniprot_id": "MTCH2_BOVIN", "mass": { "chemical_mass": 33280.0, "monoisotopic_mass": 33280.0 }, "refseq": { "ac": "NP_788807", "name": "mitochondrial carrier homolog 2 isoform 1", "summary": "This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788807" }, "gene_names": [ { "name": "MTCH2", "type": "recommended", "evidence": [ { "id": "Q9N285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N285" } ] }, { "name": "MTCH2", "type": "synonym", "evidence": [ { "id": "NP_788807", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788807" } ] } ], "protein_names": [ { "name": "Mitochondrial carrier homolog 2", "type": "recommended", "evidence": [ { "id": "Q9N285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N285/entry#names_and_taxonomy" } ] }, { "name": "mitochondrial carrier homolog 2 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_788807", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788807" } ] }, { "name": "mitochondrial carrier homolog 2", "type": "synonym", "evidence": [ { "id": "NP_788807", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788807" } ] } ], "function": [ { "annotation": "Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane. Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins. Does not mediate insertion of beta-barrel transmembrane proteins (By similarity). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis. Regulates the quiescence/cycling of hematopoietic stem cells (HSCs). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285#function" }, { "database": "UniProtKB", "id": "Q791V5", "url": "https://www.uniprot.org/uniprotkb/Q791V5#function" }, { "database": "UniProtKB", "id": "Q9Y6C9", "url": "https://www.uniprot.org/uniprotkb/Q9Y6C9#function" }, { "database": "UniProtKB", "id": "A0A3Q1M143", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M143#function" }, { "database": "UniProtKB", "id": "ARBA00055968", "url": "https://www.uniprot.org/uniprotkb/ARBA00055968#function" }, { "database": "UniProtKB", "id": "A0A3S5ZPB1", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPB1#function" } ] }, { "annotation": "This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017].", "evidence": [ { "database": "RefSeq", "id": "NP_788807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788807" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MTCH2", "url": "https://www.uniprot.org/uniprotkb/Q9N285", "locus": { "chromosome": "15", "start_pos": 77409614, "end_pos": 77429460, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018742", "url": "https://www.ensembl.org/id/ENSBTAG00000018742" } ] } } ], "crossref": [ { "id": "Q9N285", "url": "https://alphafold.ebi.ac.uk/entry/Q9N285", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018742", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018742", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "337927", "url": "https://www.ncbi.nlm.nih.gov/gene/337927", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:337927", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:337927", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HPFHVIA", "url": "https://omabrowser.org/oma/group/HPFHVIA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M143", "url": "https://www.orthodb.org/?gene=A0A3Q1M143", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3S5ZPB1", "url": "https://www.orthodb.org/?gene=A0A3S5ZPB1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q9N285", "url": "https://www.orthodb.org/?gene=Q9N285", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10780", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10780", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10780:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10780:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00153", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00153", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_788807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788807", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M143", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M143", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M143-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M143-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPB1", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3S5ZPB1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPB1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9N285-1", "url": "https://www.uniprot.org/uniprotkb/Q9N285-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLAPTVGRNIFGRQVCQLPGLFCYAQHIASIDGKRGLFTGLTPRLCSGVLGTVVHGKVLQHYQECDKAEESGSGNVQKEVSSSFDRVIKETTREMMARSAATLITHPFHVITLRSMVQFIGRESKYCGLCDSIATIYREEGILGFFAGLIPRLLGDIISLWLCNSLAYLVNTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGCPPYAPIYSSWIDCWCMLQKEGNMSRGNSLFFRKVPFGKTYCCDLRMLI", "length": 303, "header": "sp|Q9N285-1|MTCH2_BOVIN Isoform 1 of Mitochondrial carrier homolog 2 OS=Bos taurus OX=9913 GN=MTCH2 PE=2 SV=3 CANONICAL=Q9N285-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M143-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M143/entry", "sequence": { "sequence": "MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLAPTVGRNIFGRQVCQLPGLFCYAQHIASIDGKRGLFTGLTPRLCSGVLGTVVHGKVLQESGSGNVQKEVSSSFDRVIKETTREMMARSAATLITHPFHVITLRSMVQFIGRESKYCGLCDSIATIYREEGILGFFAGLIPRLLGDIISLWLCNSLAYLVNTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGCPPYAPIYSSWIDCWCMLQKEGNMSRGNSLFFRKVPFGKTYCCDLRMLI", "length": 294, "header": "tr|A0A3Q1M143-1|MTCH2_BOVIN Computationally mapped isoform of Mitochondrial carrier homolog 2 OS=Bos taurus OX=9913 GN=MTCH2 PE=2 SV=1 CANONICAL=Q9N285-1" }, "locus": { "chromosome": "15", "start_pos": 77429316, "end_pos": 77411014, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084129.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084129.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063689.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063689.1" } ] } }, { "isoform_ac": "A0A3S5ZPB1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPB1/entry", "sequence": { "sequence": "MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLAPTVGRNIFGRQVCQLPGLFCYAQHIASIDGKRGLFTGLTPRLCSGVLGTVVHGKVLQHYQECDKAEESGSGNVQKEVSSSFDRVIKETTREMMARSAATLITHPFHVITLRSMVQFIGRESKYCGLCDSIATIYREEGILGFFAGLIPRLLGDIISLWLCNSLAYLVNTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGCPPYAPIYSSWIDCWCMLQKEGNMSRGNSLFFRKVPFGKTYCCDLRMLI", "length": 303, "header": "tr|A0A3S5ZPB1-1|MTCH2_BOVIN Computationally mapped isoform of Mitochondrial carrier homolog 2 OS=Bos taurus OX=9913 GN=MTCH2 PE=2 SV=1 CANONICAL=Q9N285-1" }, "locus": { "chromosome": "15", "start_pos": 77429316, "end_pos": 77411014, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024956", "url": "https://www.ensembl.org/id/ENSBTAT00000024956" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024956", "url": "https://www.ensembl.org/id/ENSBTAP00000024956" } ] } }, { "isoform_ac": "Q9N285-1", "url": "https://www.uniprot.org/uniprotkb/Q9N285/entry#Q9N285-1", "sequence": { "sequence": "MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLAPTVGRNIFGRQVCQLPGLFCYAQHIASIDGKRGLFTGLTPRLCSGVLGTVVHGKVLQHYQECDKAEESGSGNVQKEVSSSFDRVIKETTREMMARSAATLITHPFHVITLRSMVQFIGRESKYCGLCDSIATIYREEGILGFFAGLIPRLLGDIISLWLCNSLAYLVNTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGCPPYAPIYSSWIDCWCMLQKEGNMSRGNSLFFRKVPFGKTYCCDLRMLI", "length": 303, "header": "sp|Q9N285-1|MTCH2_BOVIN Isoform 1 of Mitochondrial carrier homolog 2 OS=Bos taurus OX=9913 GN=MTCH2 PE=2 SV=3 CANONICAL=Q9N285-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 38, "start_aa": "Thr", "end_pos": 38, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr38", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:337927", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:337927", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q791V5-1", "protein_name": "Mitochondrial carrier homolog 2", "gene_name": "Mtch2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPTIGRNIFGRQVCQLPGLFCYAQHIASIDGRRGLFTGLTPRLCSGVLGTVVHGKVLQYYQESEKPEELGSVTVQKEYSSSFDRVIKETTREMIARSAATLITHPFHVITLRSMVQFIGRESKYCGLCDSIVTIYREEGIVGFFAGLIPRLLGDIISLWLCNSLAYLINTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGSPPYSPIYTSWIDCWCMLQKAGNMSRGNSLFFRKVPCGKTYCYDLRMLI", "length": 303 }, "evidence": [ { "id": "Q9N285", "url": "https://omabrowser.org/oma/group/Q9N285/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y6C9-1", "protein_name": "Mitochondrial carrier homolog 2", "gene_name": "MTCH2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPTIGRNIFGRQVCQLPGLFSYAQHIASIDGRRGLFTGLTPRLCSGVLGTVVHGKVLQHYQESDKGEELGPGNVQKEVSSSFDHVIKETTREMIARSAATLITHPFHVITLRSMVQFIGRESKYCGLCDSIITIYREEGILGFFAGLVPRLLGDILSLWLCNSLAYLVNTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGCPPYSPIYTSWIDCWCMLQKEGNMSRGNSLFFRKVPFGKTYCCDLKMLI", "length": 303 }, "evidence": [ { "id": "Q9N285", "url": "https://omabrowser.org/oma/group/Q9N285/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "protein insertion into mitochondrial outer membrane", "id": "GO:0045040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045040", "evidence": [ { "database": "UniProtKB", "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285" } ], "pmid": "" }, { "name": "lipid homeostasis", "id": "GO:0055088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055088", "evidence": [ { "database": "UniProtKB", "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285" } ], "pmid": "" }, { "name": "positive regulation of stem cell differentiation", "id": "GO:2000738", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000738", "evidence": [ { "database": "UniProtKB", "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285" } ], "pmid": "" }, { "name": "regulation of mitochondrial fusion", "id": "GO:0010635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010635", "evidence": [ { "database": "UniProtKB", "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285" } ], "pmid": "" }, { "name": "protein localization to mitochondrion", "id": "GO:0070585", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070585", "evidence": [ { "database": "UniProtKB", "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285" } ], "pmid": "" }, { "name": "establishment of protein localization to mitochondrial membrane", "id": "GO:0090151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090151", "evidence": [ { "database": "UniProtKB", "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "membrane insertase activity", "id": "GO:0032977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032977", "evidence": [ { "database": "UniProtKB", "id": "Q9N285", "url": "https://www.uniprot.org/uniprotkb/Q9N285" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9N285-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 303, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9N285-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9N285" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 38 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 277, "end_pos": 279 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"synonym", "evidence": [ { "id": "XP_059735204", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735204" } ] } ], "protein_names": [ { "name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1", "type": "recommended", "evidence": [ { "id": "A0A3Q1M144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M144/entry#names_and_taxonomy" } ] }, { "name": "Complex I-MNLL", "type": "synonym", "evidence": [ { "id": "A0A3Q1M144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M144/entry#names_and_taxonomy" } ] }, { "name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like", "type": "synonym", "evidence": [ { "id": "XP_059735204", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735204" } ] }, { "name": "NADH-ubiquinone oxidoreductase MNLL subunit", "type": "synonym", "evidence": [ { "id": "A0A3Q1M144", "database": "UniProtKB", "url": 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"field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M1G7-1", "uniprot_ac": "A0A3Q1M1G7", "uniprot_id": "A0A3Q1M1G7_BOVIN", "mass": { "chemical_mass": 54637.0, "monoisotopic_mass": 54637.0 }, "refseq": { "ac": "XP_024856186", "name": "cyclic AMP-dependent transcription factor ATF-2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856186" }, "gene_names": [ { "name": "ATF2", "type": "recommended", "evidence": [ { "id": "A0A3Q1M1G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1G7" } ] }, { "name": "ATF2", "type": "synonym", "evidence": [ { "id": "XP_024856186", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856186" } ] }, { "name": "CREB2", "type": "synonym", "evidence": [ { "id": "XP_024856186", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856186" } ] } ], "protein_names": [ { "name": "Cyclic AMP-dependent transcription factor ATF-2", "type": "recommended", "evidence": [ { "id": "A0A3Q1M1G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1G7/entry#names_and_taxonomy" } ] }, { "name": "cyclic AMP response element binding protein 2", "type": "synonym", "evidence": [ { "id": "XP_024856186", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856186" } ] }, { "name": "cyclic AMP-dependent transcription factor ATF-2", "type": "synonym", "evidence": [ { "id": "XP_024856186", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856186" } ] } ], "function": [ { "annotation": "Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3').", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RXM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM5#function" }, { "database": "UniProtKB", "id": "PIRNR003153", "url": "https://www.uniprot.org/uniprotkb/PIRNR003153#function" }, { "database": "UniProtKB", "id": "A0AAA9SPQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ3#function" }, { "database": "UniProtKB", "id": "A0AAA9TGX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGX6#function" }, { "database": "UniProtKB", "id": "A0A3Q1M1G7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1G7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1G7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1G7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1G7", "locus": { "chromosome": "2", "start_pos": 21793326, "end_pos": 21722783, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002295", "url": "https://www.ensembl.org/id/ENSBTAG00000002295" } ] } } ], "crossref": [ { "id": "A0A3Q1M1G7", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M1G7", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd12192", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12192", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14687", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14687", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509827", "url": "https://www.ncbi.nlm.nih.gov/gene/509827", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051027", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051027", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19304", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19304", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00170", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00170", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024856186", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856186", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1G7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1G7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1G7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1G7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NM00", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NM00-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHSSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQNTTGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDLSVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPVLSQIVMAPSSQSQPSGS", "length": 505, "header": "tr|A0A3Q1M1G7-1|A0A3Q1M1G7_BOVIN Isoform 1 of Cyclic AMP-dependent transcription factor ATF-2 OS=Bos taurus OX=9913 GN=ATF2 PE=3 SV=1 CANONICAL=A0A3Q1M1G7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1G7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1G7/entry", "sequence": { "sequence": "MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHSSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQNTTGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDLSVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPVLSQIVMAPSSQSQPSGS", "length": 505, "header": "tr|A0A3Q1M1G7-1|A0A3Q1M1G7_BOVIN Isoform 1 of Cyclic AMP-dependent transcription factor ATF-2 OS=Bos taurus OX=9913 GN=ATF2 PE=3 SV=1 CANONICAL=A0A3Q1M1G7-1" }, "locus": { "chromosome": "2", "start_pos": 21792990, "end_pos": 21736370, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068149.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068149.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061899.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061899.2" } ] } }, { "isoform_ac": "A0AAA9RXM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM5/entry", "sequence": { "sequence": "MYCPWMWPDQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHSSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQNTTGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDLSVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPVLSQIVMAPSSQSQPSGS", "length": 447, "header": "tr|A0AAA9RXM5-1|A0A3Q1M1G7_BOVIN Computationally mapped isoform of Cyclic AMP-dependent transcription factor ATF-2 OS=Bos taurus OX=9913 GN=ATF2 PE=3 SV=1 CANONICAL=A0A3Q1M1G7-1" }, "locus": { "chromosome": "2", "start_pos": 21792990, "end_pos": 21737925, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088331.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088331.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075903.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075903.1" } ] } }, { "isoform_ac": "A0AAA9SPQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ3/entry", "sequence": { "sequence": "MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHSSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQNTTGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDLSVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPVLSQIVMAPSSQSQPSGS", "length": 468, "header": "tr|A0AAA9SPQ3-1|A0A3Q1M1G7_BOVIN Computationally mapped isoform of Cyclic AMP-dependent transcription factor ATF-2 OS=Bos taurus OX=9913 GN=ATF2 PE=3 SV=2 CANONICAL=A0A3Q1M1G7-1" }, "locus": { "chromosome": "2", "start_pos": 21792990, "end_pos": 21736370, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122637.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122637.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084898.2", "url": "https://www.ensembl.org/id/ENSBTAP00000084898.2" } ] } }, { "isoform_ac": "A0AAA9TGX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGX6/entry", "sequence": { "sequence": "MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHSSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQNTTGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDLSVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPVLSQIVMAPSSQSQPSGS", "length": 407, "header": "tr|A0AAA9TGX6-1|A0A3Q1M1G7_BOVIN Computationally mapped isoform of Cyclic AMP-dependent transcription factor ATF-2 OS=Bos taurus OX=9913 GN=ATF2 PE=3 SV=2 CANONICAL=A0A3Q1M1G7-1" }, "locus": { "chromosome": "2", "start_pos": 21792990, "end_pos": 21736370, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129124.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129124.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097468.2", "url": "https://www.ensembl.org/id/ENSBTAP00000097468.2" } ] } }, { "isoform_ac": "A0ABI0NM00-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM00/entry", "sequence": { "sequence": "MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDLSVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPVLSQIVMAPSSQSQPSGS", "length": 144, "header": "tr|A0ABI0NM00-1|A0ABI0NM00_BOVIN Computationally mapped isoform of Activating transcription factor 2 OS=Bos taurus OX=9913 GN=ATF2 PE=4 SV=1 CANONICAL=A0A3Q1M1G7-1" }, "locus": { "chromosome": "2", "start_pos": 21792990, 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Peptide", "id": "ENSBTAP00000063609.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063609.2" } ] } }, { "isoform_ac": "F1MKH6-1", "url": "https://www.uniprot.org/uniprotkb/F1MKH6/entry", "sequence": { "sequence": "MSNLLFFCKTAELYVSDREGNDVTGDGTKEKPFKTGLKALMTVGKEPFPTIYVDSQKENERWDVISKSQMKNIRKLWHREQMKSESREKKEAEDNLRREKNLEEAKKITIKNDPSLPEPKCVSVMRVVSHTVGPRVTLFLSVSEERKNLMFLVLRDGTGFLQCVLSDDLCQCYNGVVLSTESSVAVYGMLNLTPKGKQAPGGHELSCDFWELIGLAPAGGADNLINEESDVDVQLNNRHMMIRGENMSKILKARSVITRCFRDHFFDRGYHEITPPTLVQTQVEGGATLFKLDYFGEEAYLTQSSQLYLETCIPALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFEELLNRLEDLVCDVVDRVLKSPAGNIVRDLNPNFKPPKRPFKRMNYSDAIVWLKEHNIKKEDGTFYEFGEDIPEAPERLMTDTINEPILLCRFPVEIKSFYMQRCPEDPRLTESVDVLMPNVGEIVGGSMRIWDNEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILDRYHIRDVCLYPRFVQRCKP", "length": 553, "header": "tr|F1MKH6-1|F1MKH6_BOVIN Computationally mapped isoform of Asparagine--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=NARS1 PE=3 SV=2 CANONICAL=A0A3Q1M1K1-1" }, "locus": { "chromosome": "24", "start_pos": 56848555, "end_pos": 56834282, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025659.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025659.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025659.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025659.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 507, "start_aa": "Thr", "end_pos": 507, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr507", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1K1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1K1" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1K1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1K1" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1K1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1K1" } ], "pmid": "" }, { "name": "CCR3 chemokine receptor binding", "id": "GO:0031728", "url": 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"total": 3, "go_terms": [ { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1K1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1K1" } ], "pmid": "" }, { "name": "cerebral cortex development", "id": "GO:0021987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021987", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1K1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1K1" } ], "pmid": "" }, { "name": "asparaginyl-tRNA aminoacylation", "id": "GO:0006421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006421", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1K1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1K1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11180", "name": "", "equation": "tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2KJG3-1", "A0A3Q1M1K1-1" ], "evidence": [ { "id": "11180", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11180" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M1K1", "gene_name": "NARS1", "activity": [ { "ec_number": "6.1.1.22", "activity": "tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+).", "evidence": [ { "id": "A0A3Q1M1K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1K1" } ] }, { "ec_number": "6.1.1.22", "activity": "", "evidence": [ { "id": "A0A3Q1M1K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1K1" } ] } ] }, { "uniprot_ac": "Q2KJG3", "gene_name": "NARS", "activity": [ { "ec_number": "6.1.1.22", "activity": "tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+).", "evidence": [ { "id": "Q2KJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3" } ] }, { "ec_number": "6.1.1.22", "activity": "", "evidence": [ { "id": "Q2KJG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M1K1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 558, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M1K1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M1K1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M1K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1K1" }, { "id": "PS50862", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50862" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Aminoacyl-transfer RNA synthetases class-II family profile", "eco_id": "ECO_0000259", "start_pos": 259, "end_pos": 550, "start_aa": "Arg", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.1.1.22", "ec_name": "tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+).", "evidence": [ { "id": "6.1.1.22", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.22" }, { "id": "6.1.1.22", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.1.1.22" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 507 ], "snv_sites": [], 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"o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M1S1-1", "uniprot_ac": "A0A3Q1M1S1", "uniprot_id": "A0A3Q1M1S1_BOVIN", "mass": { "chemical_mass": 65562.0, "monoisotopic_mass": 65562.0 }, "refseq": { "ac": "XP_024856561", "name": "nuclear receptor coactivator 5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856561" }, "gene_names": [ { "name": "NCOA5", "type": "recommended", "evidence": [ { "id": "A0A3Q1M1S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S1" } ] }, { "name": "NCOA5", "type": "synonym", "evidence": [ { "id": "XP_024856561", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856561" } ] } ], "protein_names": [ { "name": "Nuclear receptor coactivator 5", "type": "recommended", "evidence": [ { "id": "A0A3Q1M1S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S1/entry#names_and_taxonomy" } ] }, { "name": "Coactivator independent of AF-2", "type": "synonym", "evidence": [ { "id": "A0A3Q1M1S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S1/entry#names_and_taxonomy" } ] }, { "name": "nuclear receptor coactivator 5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024856561", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856561" } ] } ], "function": [ { "annotation": "Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1S1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S1#function" }, { "database": "UniProtKB", "id": "ARBA00057771", "url": "https://www.uniprot.org/uniprotkb/ARBA00057771#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1S1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NCOA5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S1", "locus": { "chromosome": "13", "start_pos": 74796956, "end_pos": 74824936, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014186", "url": "https://www.ensembl.org/id/ENSBTAG00000014186" } ] } } ], "crossref": [ { "id": "A0A3Q1M1S1", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M1S1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014186", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014186", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540762", "url": "https://www.ncbi.nlm.nih.gov/gene/540762", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR036621", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036621", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052600", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052600", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PMEEGVR", "url": "https://omabrowser.org/oma/group/PMEEGVR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M1S1", "url": "https://www.orthodb.org/?gene=A0A3Q1M1S1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23295", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23295", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23295:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23295:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_024856561", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856561", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1S1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1S1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNTAPSRPSPTRRDPYGFGDSRDTRRDRSPIRGSPRREPRDGRNGRDARDGRDMRDPRDLRDHRDSRDIRDHRDSRSMRDARDMRDLRDFRDLRETRNFRDHRDPMYDRYREMRDSRDPILRREGSYDRYLRMDDYCRRKDDAYFDRYRDSFDGRGPPGPESQSRVKERLKREERRREELYRQYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNECREKEREEIARQAAKMADEAILQERERGGPEEGMRGGHPPAIQSLLNLLADNRYLTAEETDKIINYLRERKERLMRSSTDSLPGPISRQPLGATSGASLKTQPSSQPLQSGQVLPSATPTPAAPPTSQQELQAKILSLFNSGTVAANSGSASPSVAAGNTQNQNFSTAANSQPQQRSQASGNQPPSILGQAGSARNMGPRPGAPSQGLFGQPSTLLAPASNLASQRPVSSTSINFDNPSVQKALDTLIQSGPALSHLVSQTTAQVRQPQAPLGSFQRHY", "length": 579, "header": "tr|A0A3Q1M1S1-1|A0A3Q1M1S1_BOVIN Isoform 1 of Nuclear receptor coactivator 5 OS=Bos taurus OX=9913 GN=NCOA5 PE=4 SV=2 CANONICAL=A0A3Q1M1S1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1S1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S1/entry", "sequence": { "sequence": "MNTAPSRPSPTRRDPYGFGDSRDTRRDRSPIRGSPRREPRDGRNGRDARDGRDMRDPRDLRDHRDSRDIRDHRDSRSMRDARDMRDLRDFRDLRETRNFRDHRDPMYDRYREMRDSRDPILRREGSYDRYLRMDDYCRRKDDAYFDRYRDSFDGRGPPGPESQSRVKERLKREERRREELYRQYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNECREKEREEIARQAAKMADEAILQERERGGPEEGMRGGHPPAIQSLLNLLADNRYLTAEETDKIINYLRERKERLMRSSTDSLPGPISRQPLGATSGASLKTQPSSQPLQSGQVLPSATPTPAAPPTSQQELQAKILSLFNSGTVAANSGSASPSVAAGNTQNQNFSTAANSQPQQRSQASGNQPPSILGQAGSARNMGPRPGAPSQGLFGQPSTLLAPASNLASQRPVSSTSINFDNPSVQKALDTLIQSGPALSHLVSQTTAQVRQPQAPLGSFQRHY", "length": 579, "header": "tr|A0A3Q1M1S1-1|A0A3Q1M1S1_BOVIN Isoform 1 of Nuclear receptor coactivator 5 OS=Bos taurus OX=9913 GN=NCOA5 PE=4 SV=2 CANONICAL=A0A3Q1M1S1-1" }, "locus": { "chromosome": "13", "start_pos": 74814129, "end_pos": 74797960, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077488.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077488.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063906.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063906.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 420, "start_aa": "Thr", "end_pos": 420, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr420", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YKC6-1", "protein_name": "Nuclear receptor coactivator 5", "gene_name": "NCOA5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRPMKRCCSATLLHSRTSSEPCPKSWIWNESKMARGRKSNSIKQSDFTNSTNPQDLERRLFVGNLPTDHMTREEMEEIFSKYGKIRALSMYHGYGFVQYDRLEDVQAALDGEKGRLYKGYRLDINKAAERRNMNKASSRSSPARREPYAYGDGRDNRRDRSPLRGSPRRDPRDGRDGRNGRDSRDTRDIRARDIRDARDHRDPRDLRDLRDPRDIRDPRDLRDPRDVRDFRDPREPLYDRYRDPRDMRNPRDMRDPRDMRDPRDMRDPRDPLYRRDEPYDRYLRMDDYYRRKDDSYYDRYKEHFDRAPVNSEDRLKREERRREELYRQYYEEIKRRFDAERPVDCSVIVVDKQTKEYAESVGRKVRDLGMVVDLIFLNTELLLTQALDDVSRGGSPFAIVITQQHQVHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKAETREKEREEIARQAAKMADEAILQERERPPPMEEGARGGHPHPPGIQTLLNLLADNRYLTAEETDKVINYLRDRKERLLRGSTDSLQAPMSRPSLGAPSAPSLGSQSSLPSSQTHQGSQPLVSAPSVPASSANPQQELQAKILSLFNSGAAAAAVANSSSAPTVGTSGGTPSQNFTNMTSNQARSAQMSAGNLNQAQQRLQTPNTQLPSLQGPSRNAGPRPGAPPPAQSLYGQHQNRLPAPGSVPAQRPVSSGINFDNPSVQKALDTLIQSGPALSHLVSQTVAQGRAGSSTQQPMGSYQRHY", "length": 747 }, "evidence": [ { "id": "A0A3Q1M1S1", "url": "https://omabrowser.org/oma/group/A0A3Q1M1S1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZEI6-1", "protein_name": "Nuclear receptor coactivator 5", "gene_name": "Ncoa5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNTAPSRPSPTRRDPYSFGDSRDTRRDRSPIRGSPRREPRDGRNGRDTRDRDIRDPRELRDRRDSRDIRDHRDSRSVREARDLRDFRDFRDLRDSRDFRDHRDPVYDRYREIRDSRDPLYRREGSYDRYLRVDDYCRRKDDSYFDRYRDSFDGRGPPGPESQSRAKERLKREERRREELYRRYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNDCREKEREEIARQAAKMANDAILQERDRGGPEEGGRGGHPPAIQSLINLLADNRYLTAEETDKIINYLRERKERLLRSSADSLPGPISRQPLGAASGSSLKTQPSSQPLQSGQVLPSATPTPAAPPTSQQELQAKILSLFNSGAVAANSSSASPSVATGSSQNQNFSTAANSQPQQRPQASGNQPPNIVGQAGSARNMGPRPGAPSQGLFGQPSSRLAPASNMASQRPVSSTGINFDNPSVQKALDTLIQSGPALSHLVSQTAAQVGRPQAPMGSYQRHY", "length": 578 }, "evidence": [ { "id": "A0A3Q1M1S1", "url": "https://omabrowser.org/oma/group/A0A3Q1M1S1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SC53-1", "protein_name": "Nuclear receptor coactivator 5", "gene_name": "NCOA5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNTAPSRPSPTRRDPYGFGDSRDTRRDRSPIRGSPRREPRDGRNGRDARDSRDMRDMRDMRDPRDLRDHRDSRDMRDHRDSRSMRDARDLRDLRDFRDLRDSRDFRDHRDPMYDRYRDMRDSRDPMYRREGSYDRYLRMDDYCRRKDDSYFDRYRDSFDGRGPPGPENQSRAKERLKREERRREELYRQYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNECREKEREEIARQAAKMADEAILQERERGGPDEGMRGGHPPAIQSLINLLADNRYLTAEETDKIINYLRERKERLMRSSTDSLPGPISRQPLGASSGASLKTQPSSQPLQSGQVLPSATPTPAAAPTSQQELQAKILSLFNSGTVAANSSSASPSVAAGNTQNQNFSTAANSQPQQRSQASGNQPPNILGQAGSARNMGPRPGAPSQGLFGQPSTRLAPASNLASQRPVSSTAINFDNPSVQKALDTLIQSGPALSHLVSQTTAQVGRPQAPMGSYQRHY", "length": 585 }, "evidence": [ { "id": "A0A3Q1M1S1", "url": "https://omabrowser.org/oma/group/A0A3Q1M1S1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H8U6-1", "protein_name": "Nuclear receptor coactivator 5", "gene_name": "Ncoa5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNTAPSRPSPTRRDPYGFGDSRDTRRDRSPIRGSPRREPRDGRNGRDARDSRDIRDPRELRDHRDSRDIRDHRDSRSIRDARDLRDFRDFRDLRDSRDFRDHRDPVYDRYRDIRDSRDPLYRREGSYDRYLRMDDYYRRKDDSYFDRYRDSFDGRGPRAKERLKREERRREELYRQYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNNCREKEREEIARQAAKMANEAILQERDRGGPEEGGRGGHPPAIQSLINLLADNRYLTAEETDRVIDYLRGRKERLLRSSAADALPGPISRQPLGAASGTSLKTQSSSQPLQSGQVLPSATPTPAAPPTSQQELQAKILSLFNSGTVSANSSSASPSVAAGSSQNQNFSTAANSQPQQRPQASGNQPPSIVGQAGSARNMGPRPGAPSQGLFGQPSSRLAPASNMASQRPVSSTGINFDNPSVQKALDTLIQSGPALSHLVSQTAAQVGRPQAPIGSYQRHY", "length": 573 }, "evidence": [ { "id": "A0A3Q1M1S1", "url": "https://omabrowser.org/oma/group/A0A3Q1M1S1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q91W39-1", "protein_name": "Nuclear receptor coactivator 5", "gene_name": "Ncoa5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNTAPSRPSPTRRDPYSFGDSRDTRRDRSPIRGSPRREPRDGRNGRDARDSRDIRDPRDLRDRRDSRDIRDHRDSRSVREARDLRDFRDFRDLRDSRDFRDHRDPVYDRYRDIRDSRDPLYRREGSYDRYLRVDDYCRRKDDSYFDRYRDSFDGRGPPGPESQSRAKERLKREERRREELYRRYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNDCREKEREEIARQAAKMANDAILQERDRGGPEEGGRGGHPPAIQSLINLLADNRYLTAEETDKIINYLRERKERLLRSSADSLPGPISRQPLGAASGSSLKSQPSSQPLQSGQVLPSATPTPAAPPTSQQELQAKILSLFNSGAVAANSSSASPSVATGSSQNQNFSTAANSQPQQRPQASGNQPPNIVGQAGSARNMGPRPGAPSQGLFGQPSSRLAPASTMASQRPVSSTGINFDNPSVQKALDTLIQSGPALSHLVSQTAAQVGRPQAPMGSYQRHY", "length": 579 }, "evidence": [ { "id": "A0A3Q1M1S1", "url": "https://omabrowser.org/oma/group/A0A3Q1M1S1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HCD5-1", "protein_name": "Nuclear receptor coactivator 5", "gene_name": "NCOA5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNTAPSRPSPTRRDPYGFGDSRDSRRDRSPIRGSPRREPRDGRNGRDARDSRDIRDPRDLRDHRHSRDLRDHRDSRSVRDVRDVRDLRDFRDLRDSRDFRDQRDPMYDRYRDMRDSRDPMYRREGSYDRYLRMDDYCRRKDDSYFDRYRDSFDGRGPPGPESQSRAKERLKREERRREELYRQYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNECREKEREEIARQAAKMADEAILQERERGGPEEGVRGGHPPAIQSLINLLADNRYLTAEETDKIINYLRERKERLMRSSTDSLPGPISRQPLGATSGASLKTQPSSQPLQSGQVLPSATPTPSAPPTSQQELQAKILSLFNSGTVTANSSSASPSVAAGNTPNQNFSTAANSQPQQRSQASGNQPPSILGQGGSAQNMGPRPGAPSQGLFGQPSSRLAPASNMTSQRPVSSTGINFDNPSVQKALDTLIQSGPALSHLVSQTTAQMGQPQAPMGSYQRHY", "length": 579 }, "evidence": [ { "id": "A0A3Q1M1S1", "url": "https://omabrowser.org/oma/group/A0A3Q1M1S1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1S1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1S1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S1" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1S1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1S1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M1S1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 579, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M1S1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M1S1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 420 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 464, "end_pos": 466 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M1S9-1", "uniprot_ac": "A0A3Q1M1S9", "uniprot_id": "A0A3Q1M1S9_BOVIN", "mass": { "chemical_mass": 35654.0, "monoisotopic_mass": 35654.0 }, "refseq": { "ac": "NP_001376704", "name": "olfactory receptor family 52 subfamily B member 4K", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376704" }, "gene_names": [ { "name": "OR52B4K", "type": "recommended", "evidence": [ { "id": "A0A3Q1M1S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S9" } ] }, { "name": "OR52B4K", "type": "synonym", "evidence": [ { "id": "NP_001376704", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376704" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0A3Q1M1S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S9/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 52B4", "type": "synonym", "evidence": [ { "id": "NP_001376704", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376704" } ] }, { "name": "olfactory receptor family 52 subfamily B member 4K", "type": "synonym", "evidence": [ { "id": "NP_001376704", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376704" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1S9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S9#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376704" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1S9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S9#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1S9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR52B4K", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S9", "locus": { "chromosome": "15", "start_pos": 50783578, "end_pos": 50784522, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000062666", "url": "https://www.ensembl.org/id/ENSBTAG00000062666" } ] } } ], "crossref": [ { "id": "A0A3Q1M1S9", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M1S9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000048614", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000048614", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506452", "url": "https://www.ncbi.nlm.nih.gov/gene/506452", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506452", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506452", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KHMWISI", "url": "https://omabrowser.org/oma/group/KHMWISI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M1S9", "url": "https://www.orthodb.org/?gene=A0A3Q1M1S9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF386", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF386", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376704", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1S9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1S9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTVFNHTGVSHTVFYFVGIPGLEDQHVWISIPFFISYVIALLGNSLLIFIILTKRSLHEPMYLFLCMLSGADLVLSTCTIPQALAIFWFNAREISLDRCITQLFFIHSTFISESGILLVMAFDRYIAICYPLRYTTILTHTLIGKIGVTIFLRSYGTMFPIIFLLKRLTFCKSNIFPTTVCEHIAVAKFSCDDIRVNFWYGFFVLLSTVTLDVVLIFVSYMLILCAVFRIPSPDARHKTLNTCGSHVCVIILFYGPGIFSAFTPRFARHILPHVHVLLANVCILAPTMLNPIIYGIKTKQIQDQVSQVLCQKKI", "length": 314, "header": "tr|A0A3Q1M1S9-1|A0A3Q1M1S9_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR52B4K PE=3 SV=1 CANONICAL=A0A3Q1M1S9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1S9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S9/entry", "sequence": { "sequence": "MTVFNHTGVSHTVFYFVGIPGLEDQHVWISIPFFISYVIALLGNSLLIFIILTKRSLHEPMYLFLCMLSGADLVLSTCTIPQALAIFWFNAREISLDRCITQLFFIHSTFISESGILLVMAFDRYIAICYPLRYTTILTHTLIGKIGVTIFLRSYGTMFPIIFLLKRLTFCKSNIFPTTVCEHIAVAKFSCDDIRVNFWYGFFVLLSTVTLDVVLIFVSYMLILCAVFRIPSPDARHKTLNTCGSHVCVIILFYGPGIFSAFTPRFARHILPHVHVLLANVCILAPTMLNPIIYGIKTKQIQDQVSQVLCQKKI", "length": 314, "header": "tr|A0A3Q1M1S9-1|A0A3Q1M1S9_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR52B4K PE=3 SV=1 CANONICAL=A0A3Q1M1S9-1" }, "locus": { "chromosome": "15", "start_pos": 50784522, "end_pos": 50783581, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078178.1", "url": "https://www.ensembl.org/id/ENSBTAT00000078178.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062021.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062021.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506452", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506452", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1B0GSG0-1", "protein_name": "Olfactory receptor", "gene_name": "Or52b4i", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGTVNHTDISHTVFHLLGIPGLEDQHMWISIPFFISYITALLGNSLLIFIILTRPSLHEPMYLFLCMLAGADIVLSTSTVPQALSIFWFHAGEISLDRCITQLFFIHSTFISESGILLVMAFDRYIAICYPLRYITVLTKSLIGKIGVGIFLRSYGTIFPIIFLLKRLTFCRTNILPHTACEHAGLSKYACNDLQVHIWYGFFVLMSTVNLDVVLIFVSYVLILRAVFHMPSQDARHKALNTCGSHVCVIILFYGPGIFSTLNHQFGYKISTGVHVLLANVCILAPPMLNPIIYGVKTKQIRDQVTHVLFLKVI", "length": 314 }, "evidence": [ { "id": "A0A3Q1M1S9", "url": "https://omabrowser.org/oma/group/A0A3Q1M1S9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1S9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S9" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1S9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1S9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M1S9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 314, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M1S9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M1S9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M1S9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1S9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 294, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M1T1-1", "uniprot_ac": "A0A3Q1M1T1", "uniprot_id": "A0A3Q1M1T1_BOVIN", "mass": { "chemical_mass": 285487.0, "monoisotopic_mass": 285487.0 }, "refseq": { "ac": "XP_024839826", "name": "zinc finger protein 40 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839826" }, "gene_names": [ { "name": "HIVEP1", "type": "recommended", "evidence": [ { "id": "A0A3Q1M1T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1" } ] }, { "name": "HIVEP1", "type": "synonym", "evidence": [ { "id": "XP_024839826", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839826" } ] } ], "protein_names": [ { "name": "Zinc finger protein 40", "type": "recommended", "evidence": [ { "id": "A0A3Q1M1T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 40 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024839826", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839826" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HIVEP1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1", "locus": { "chromosome": "23", "start_pos": 44281845, "end_pos": 44417853, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001252", "url": "https://www.ensembl.org/id/ENSBTAG00000001252" } ] } } ], "crossref": [ { "id": "ENSBTAG00000001252", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001252", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "529115", "url": "https://www.ncbi.nlm.nih.gov/gene/529115", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529115", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529115", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EGKQDCH", "url": "https://omabrowser.org/oma/group/EGKQDCH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M1T1", "url": "https://www.orthodb.org/?gene=A0A3Q1M1T1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MI25", "url": "https://www.orthodb.org/?gene=F1MI25", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45944", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45944", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45944:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45944:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024839826", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839826", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1T1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1T1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI25", "url": "https://www.uniprot.org/uniprotkb/F1MI25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI25-1", "url": "https://www.uniprot.org/uniprotkb/F1MI25-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRTKQIHPRNLRDKIEEAQKELNGAEVSKKELLEAGIKGTSESLKGVKRKKIVAENHLKKIPKSPLRNPLQAKHRQNTEESPFPLLAGAAEPHKKQSHSPAKAGGRPLTKHNGETPGLTAGAPKPEAPVCPRKPPLLLQPSEPRRWRSEGPDLAKAGVPEGKSDPGSPPSKGKAEHREAPASSGHSSPPSSFANTAFDVLLKAMEPELSTLSQKGSPCAAKIENLRPNKTARAPTHLHGGPREAADPHLPDAAAPSEQPLPPRTLYPSGPVSATQRRDPAVVPASSPAYHIHELPVPKHGPQSQQLPACSGFPPSLASLQGQENAQLEHVYTAAATSPPGRTQVTPSNQQVDAAVSVPVSPTPSTQSPPTPIYNSSPVAAVVNHSVEQMCSLLLKDQKPKKQGKYICEYCNRACAKPSVLLKHIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHTIKLGLVLQPDAGGLFVSHESPKALSIHSDVEDSGDSEEDGAGDERPNDPGSVDLQPVQMIRMLSSSEALPKSGSIPSNPERMVGDFALQDGSSESQAVAELPKVVVHPISVSPLRVDSPKVTDSKPELPGTQKDLQGTRVLSHPAWASSLEADEKAHQKGDPTQPDGKPESPVGAAHAQLQRQQATDYCQEQQGKLLSPRSLGSTDSGYFSRSESADQTVSPPTPFARTLPAPEQDSAKNSGPSTPRVSTPAASAVPAGEKAPLLPGQMRPPLATKTLEERISKLISDNEALVDDKQLDSVKPRRTSLSRRGSIDSPKSYIFKDSFQFDLKPMGRRTSSSSDIPKSPFTPTEKSKQVFLLSVPSLDCLPITRSNSMPTTGYSAVPASIIPAPHPLRGSQSFDDKIGAFYDDVFVPGPNPSVTQSGHPRTLVRQAAVEDSSASENHVLGAGQPWDESHPGGSPAGETAAPRSKPPAPGSHLEKKKSHQGRGTMFECETCRNRYRKLENFENHKKFYCSELHGPKTKVAVRDPEHSSVPGGAQHYRVAGATGVWEQTTQMRKRRKMKSVGDDDELQQNESGAPPKSSEGSRSQSALGPAPSLSQQNLAIPSELQPRNLQRQTTQIQLGTRGPNQPRDPKPSSVLEEPMSSAAQDRAEPKRHGAGISVIQHTNSLSRPGAFDKLDAGEGASPVPFQELRTGKPGSLSVRGISQEEGCPSRHTSQPTLSDAPRGELQDGSRKISGERHVLGQPSRLVRQHSIQVPEILVTEEPDRDLESQGHDAEKSEKFSWPQRSETLSKLPTEKLPPKKKRLRLAEMEHSSAESSFDSTLSRSLSRDSSLSHTSSFSASLDVEDVSKTEASPKIDFLHKADFLLIPAGSNTLSVPGGHREMRRAASEQIHCLQTSMEVSDFRSKSFDCGSIAPSQKVPPAESHPPTSPSGVGVAGHVPLLERRRGPLIRQISLNIAPENQLAPGNPLSFQTIAPPAVNTVPLQGPQLTHTVSAEFPASTLHSQTPVKDVRAEMASSHSPNLFPLQQLLGIHLLNQIPVPLSHPDTHMSLQVSSTQSVKPDASPGGGCVPSKSEDCFAPKYQLQCLAVPSSQPCASNPVQPLPKQGLSDAAGATPRATSLTLPAKLAEATSNSCPPPPLKVGALGGQVPKGPTSLTLSTHLQTQVSTYCFAAVTALPQILVTQDLSNQPICQANRSTVPISEEQSSVPKPQNDPRNALPNPEGELVGQPVFSEMGQNPSPSESSPTTPKMSVGRLSPQQESSASSKRMLSPANSLDIAMEKHQKRAKDENGAVCATDTRPLEAVGSRAPDGSKQKKPVLVRQVCTTEPLEAVTLEQDVFPHPEVSTEALHLTAVSPADNVSSGHCKPVAREPMKEVQEFESIPSAALLTPTVQNPAAPAEKTHISPLESIDNHQERKSPGIKNPGNKANVQEQSQPAATTPSMREAGDTQPSTSFPSLKTATSSTWCCLMRQKALHLPQKDQKTSAYTDWTVSASDPNPLGLPTKVALSLLNSKQKTGKSLYCQAITTHFKSDLLVYSSKWKSNLSKRALGNQKSTVVEFSSKDASEINSEQDKENSLIKSEPRRIKIFDGGYKSNEEYVYVRGRGRGKYICEECGIRCKKPSMLKKHIRTHTDVRPYHCTYCNFSFKTKGNLTKHMKSKTHSKKCLDLGVSVGLIDEQDTEESDEKQRFSFERSGYDPEESDGAEDDDIENEEEDEDSQAESVLSAAPSAAASPQHLPARGGPGDPTGADEDASAPEGSPGGPTDAMDVLPRALPTKMTVLSALPSDRGGSPGSPGSAGPRAAGNAEAAACPPEGAPRSPCHQMSVDYPNPKEMLSGSAAGKAVALTQGAPCLSLPPPPASERSPQPGGAPPSTSPRPGPQEQKPQAALPPPAGLPSPQTHLFSHLPLHSQQQSRTPYNMVPVGGIQVVPAGLTYSTFVPIQAGPVQLTIPAVNVIHRPLGTPGDLSADGPGTASPAGVAELSSVVPCIPIGQIRVPTLQPLPALSMETVNIVGLASASLGPPVRPPGLALNAVGLQVVAANPASQSSPAPPAPIPGLQIVNIALPTLIPSVSQVPVDIQGAPEMPAPPNRASREAPPTQPVGAHPGGRTPSPQGSPGVQRESAQKGLDPPAPARDQARRDSSSPRDTGKGASANHPKPRHDTPGAPCKPTSAPLPPPGRPRLPLDPEGPRPPPRRPVTQFSDVSSDDDEDRLVIAT", "length": 2684, "header": "tr|A0A3Q1M1T1-1|A0A3Q1M1T1_BOVIN Isoform 1 of Zinc finger protein 40 OS=Bos taurus OX=9913 GN=HIVEP1 PE=4 SV=1 CANONICAL=A0A3Q1M1T1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1T1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1/entry", "sequence": { "sequence": "MPRTKQIHPRNLRDKIEEAQKELNGAEVSKKELLEAGIKGTSESLKGVKRKKIVAENHLKKIPKSPLRNPLQAKHRQNTEESPFPLLAGAAEPHKKQSHSPAKAGGRPLTKHNGETPGLTAGAPKPEAPVCPRKPPLLLQPSEPRRWRSEGPDLAKAGVPEGKSDPGSPPSKGKAEHREAPASSGHSSPPSSFANTAFDVLLKAMEPELSTLSQKGSPCAAKIENLRPNKTARAPTHLHGGPREAADPHLPDAAAPSEQPLPPRTLYPSGPVSATQRRDPAVVPASSPAYHIHELPVPKHGPQSQQLPACSGFPPSLASLQGQENAQLEHVYTAAATSPPGRTQVTPSNQQVDAAVSVPVSPTPSTQSPPTPIYNSSPVAAVVNHSVEQMCSLLLKDQKPKKQGKYICEYCNRACAKPSVLLKHIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHTIKLGLVLQPDAGGLFVSHESPKALSIHSDVEDSGDSEEDGAGDERPNDPGSVDLQPVQMIRMLSSSEALPKSGSIPSNPERMVGDFALQDGSSESQAVAELPKVVVHPISVSPLRVDSPKVTDSKPELPGTQKDLQGTRVLSHPAWASSLEADEKAHQKGDPTQPDGKPESPVGAAHAQLQRQQATDYCQEQQGKLLSPRSLGSTDSGYFSRSESADQTVSPPTPFARTLPAPEQDSAKNSGPSTPRVSTPAASAVPAGEKAPLLPGQMRPPLATKTLEERISKLISDNEALVDDKQLDSVKPRRTSLSRRGSIDSPKSYIFKDSFQFDLKPMGRRTSSSSDIPKSPFTPTEKSKQVFLLSVPSLDCLPITRSNSMPTTGYSAVPASIIPAPHPLRGSQSFDDKIGAFYDDVFVPGPNPSVTQSGHPRTLVRQAAVEDSSASENHVLGAGQPWDESHPGGSPAGETAAPRSKPPAPGSHLEKKKSHQGRGTMFECETCRNRYRKLENFENHKKFYCSELHGPKTKVAVRDPEHSSVPGGAQHYRVAGATGVWEQTTQMRKRRKMKSVGDDDELQQNESGAPPKSSEGSRSQSALGPAPSLSQQNLAIPSELQPRNLQRQTTQIQLGTRGPNQPRDPKPSSVLEEPMSSAAQDRAEPKRHGAGISVIQHTNSLSRPGAFDKLDAGEGASPVPFQELRTGKPGSLSVRGISQEEGCPSRHTSQPTLSDAPRGELQDGSRKISGERHVLGQPSRLVRQHSIQVPEILVTEEPDRDLESQGHDAEKSEKFSWPQRSETLSKLPTEKLPPKKKRLRLAEMEHSSAESSFDSTLSRSLSRDSSLSHTSSFSASLDVEDVSKTEASPKIDFLHKADFLLIPAGSNTLSVPGGHREMRRAASEQIHCLQTSMEVSDFRSKSFDCGSIAPSQKVPPAESHPPTSPSGVGVAGHVPLLERRRGPLIRQISLNIAPENQLAPGNPLSFQTIAPPAVNTVPLQGPQLTHTVSAEFPASTLHSQTPVKDVRAEMASSHSPNLFPLQQLLGIHLLNQIPVPLSHPDTHMSLQVSSTQSVKPDASPGGGCVPSKSEDCFAPKYQLQCLAVPSSQPCASNPVQPLPKQGLSDAAGATPRATSLTLPAKLAEATSNSCPPPPLKVGALGGQVPKGPTSLTLSTHLQTQVSTYCFAAVTALPQILVTQDLSNQPICQANRSTVPISEEQSSVPKPQNDPRNALPNPEGELVGQPVFSEMGQNPSPSESSPTTPKMSVGRLSPQQESSASSKRMLSPANSLDIAMEKHQKRAKDENGAVCATDTRPLEAVGSRAPDGSKQKKPVLVRQVCTTEPLEAVTLEQDVFPHPEVSTEALHLTAVSPADNVSSGHCKPVAREPMKEVQEFESIPSAALLTPTVQNPAAPAEKTHISPLESIDNHQERKSPGIKNPGNKANVQEQSQPAATTPSMREAGDTQPSTSFPSLKTATSSTWCCLMRQKALHLPQKDQKTSAYTDWTVSASDPNPLGLPTKVALSLLNSKQKTGKSLYCQAITTHFKSDLLVYSSKWKSNLSKRALGNQKSTVVEFSSKDASEINSEQDKENSLIKSEPRRIKIFDGGYKSNEEYVYVRGRGRGKYICEECGIRCKKPSMLKKHIRTHTDVRPYHCTYCNFSFKTKGNLTKHMKSKTHSKKCLDLGVSVGLIDEQDTEESDEKQRFSFERSGYDPEESDGAEDDDIENEEEDEDSQAESVLSAAPSAAASPQHLPARGGPGDPTGADEDASAPEGSPGGPTDAMDVLPRALPTKMTVLSALPSDRGGSPGSPGSAGPRAAGNAEAAACPPEGAPRSPCHQMSVDYPNPKEMLSGSAAGKAVALTQGAPCLSLPPPPASERSPQPGGAPPSTSPRPGPQEQKPQAALPPPAGLPSPQTHLFSHLPLHSQQQSRTPYNMVPVGGIQVVPAGLTYSTFVPIQAGPVQLTIPAVNVIHRPLGTPGDLSADGPGTASPAGVAELSSVVPCIPIGQIRVPTLQPLPALSMETVNIVGLASASLGPPVRPPGLALNAVGLQVVAANPASQSSPAPPAPIPGLQIVNIALPTLIPSVSQVPVDIQGAPEMPAPPNRASREAPPTQPVGAHPGGRTPSPQGSPGVQRESAQKGLDPPAPARDQARRDSSSPRDTGKGASANHPKPRHDTPGAPCKPTSAPLPPPGRPRLPLDPEGPRPPPRRPVTQFSDVSSDDDEDRLVIAT", "length": 2684, "header": "tr|A0A3Q1M1T1-1|A0A3Q1M1T1_BOVIN Isoform 1 of Zinc finger protein 40 OS=Bos taurus OX=9913 GN=HIVEP1 PE=4 SV=1 CANONICAL=A0A3Q1M1T1-1" }, "locus": { "chromosome": "23", "start_pos": 44410631, "end_pos": 44282432, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085644.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085644.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063701.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063701.1" } ] } }, { "isoform_ac": "F1MI25-1", "url": "https://www.uniprot.org/uniprotkb/F1MI25/entry", "sequence": { "sequence": "MPRTKQIHPRNLRDKIEEAQKELNGAEVSKKELLEAGIKGTSESLKGVKRKKIVAENHLKKIPKSPLRNPLQAKHRQNTEESPFPLLAGAAEPHKKQSHSPAKAGGRPLTKHNGETPGLTAGAPKPEAPVCPRKPPLLLQPSEPRRWRSEGPDLAKAGVPEGKSDPGSPPSKGKAEHREAPASSGHSSPPSSFANTAFDVLLKAMEPELSTLSQKGSPCAAKIENLRPNKTARAPTHLHGGPREAADPHLPDAAAPSEQPLPPRTLYPSGPVSATQRRDPAVVPASSPAYHIHELPVPKHGPQSQQLPACSGFPPSLASLQGQENAQLEHVYTAAATSPPGRTQVTPSNQQVDAAVSVPVSPTPSTQSPPTPIYNSSPVAAVVNHSVEQMCSLLLKDQKPKKQGKYICEYCNRACAKPSVLLKHIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHTIKLGLVLQPDAGGLFVSHESPKALSIHSDVEDSGDSEEDGAGDERPNDPGSVDLQPVQMIRMLSSSEALPKSGSIPSNPERMVGDFALQDGSSESQAVAELPKVVVHPISVSPLRVDSPKVTDSKPELPGTQKDLQGTRVLSHPAWASSLEADEKAHQKGDPTQPDGKPESPVGAAHAQLQRQQATDYCQEQQGKLLSPRSLGSTDSGYFSRSESADQTVSPPTPFARTLPAPEQDSAKNSGPSTPRVSTPAASAVPAGEKAPLLPGQMRPPLATKTLEERISKLISDNEALVDDKQLDSVKPRRTSLSRRGSIDSPKSYIFKDSFQFDLKPMGRRTSSSSDIPKSPFTPTEKSKQVFLLSVPSLDCLPITRSNSMPTTGYSAVPASIIPAPHPLRGSQSFDDKIGAFYDDVFVPGPNPSVTQSGHPRTLVRQAAVEDSSASENHVLGAGQPWDESHPGGSPAGETAAPRSKPPAPGSHLEKKKSHQGRGTMFECETCRNRYRKLENFENHKKFYCSELHGPKTKVAVRDPEHSSVPGGAQHYRVAGATGVWEQTTQMRKRRKMKSVGDDDELQQNESGAPPKSSEGSRSQSALGPAPSLSQQNLAIPSELQPRNLQRQTTQIQLGTRGPNQPRDPKPSSVLEEPMSSAAQDRAEPKRHGAGISVIQHTNSLSRPGAFDKLDAGEGASPVPFQELRTGKPGSLSVRGISQEEGCPSRHTSQPTLSDAPRGELQDGSRKISGERHVLGQPSRLVRQHSIQVPEILVTEEPDRDLESQGHDAEKSEKFSWPQRSETLSKLPTEKLPPKKKRLRLAEMEHSSAESSFDSTLSRSLSRDSSLSHTSSFSASLDVEDVSKTEASPKIDFLHKADFLLIPAGSNTLSVPGGHREMRRAASEQIHCLQTSMEVSDFRSKSFDCGSIAPSQKVPPAESHPPTSPSGVGVAGHVPLLERRRGPLIRQISLNIAPENQLAPGNPLSFQTIAPPAVNTVPLQGPQLTHTVSAEFPASTLHSQTPVKDVRAEMASSHSPNLFPLQQLLGIHLLNQIPVPLSHPDTHMSLQVSSTQSVKPDASPGGGCVPSKSEDCFAPKYQLQCLAVPSSQPCASNPVQPLPKQGLSDAAGATPRATSLTLPAKLAEATSNSCPPPPLKVGALGGQVPKGPTSLTLSTHLQTQVSTYCFAAVTALPQILVTQDLSNQPICQANRSTVPISEEQSSVPKPQNDPRNALPNPEGELVGQPVFSEMGQNPSPSESSPTTPKMSVGRLSPQQESSASSKRMLSPANSLDIAMEKHQKRAKDENGAVCATDTRPLEAVGSRAPDGSKQKKPVLVRQVCTTEPLEAVTLEQDVFPHPEVSTEALHLTAVSPADNVSSGHCKPVAREPMKEVQEFESIPSAALLTPTVQNPAAPAEKTHISPLESIDNHQERKSPGIKNPGNKANVQEQSQPAATTPSMREAGDTQPSTSFPSLKTATSSTWCCLMRQKALHLPQKDQKTSAYTDWTVSASDPNPLGLPTKVALSLLNSKQKTGKSLYCQAITTHFKSDLLVYSSKWKSNLSKRALGNQKSTVVEFSSKDASEINSEQDKENSLIKSEPRRIKIFDGGYKSNEEYVYVRGRGRGKYICEECGIRCKKPSMLKKHIRTHTDVRPYHCTYCNFSFKTKDEKQRFSFERSGYDPEESDGAEDDDIENEEEDEDSQAESVLSAAPSAAASPQHLPARGGPGDPTGADEDASAPEGSPGGPTDAMDVLPRALPTKMTVLSALPSDRGGSPGSPGSAGPRAAGNAEAAACPPEGAPRSPCHQMSVDYPNPKEMLSGSAAGKAVALTQGAPCLSLPPPPASERSPQPGGAPPSTSPRPGPQEQKPQAALPPPAGLPSPQTHLFSHLPLHSQQQSRTPYNMVPVGGIQVVPAGLTYSTFVPIQAGPVQLTIPAVNVIHRPLGTPGDLSADGPGTASPAGVAELSSVVPCIPIGQIRVPTLQPLPALSMETVNIVGLASASLGPPVRPPGLALNAVGLQVVAANPASQSSPAPPAPIPGLQIVNIALPTLIPSVSQVPVDIQGAPEMPAPPNRASREAPPTQPVGAHPGGRTPSPQGSPGVQRESAQKGLDPPAPARDQARRDSSSPRDTGKGASANHPKPRHDTPGAPCKPTSAPLPPPGRPRLPLDPEGPRPPPRRPVTQFSDVSSDDDEDRLVIAT", "length": 2650, "header": "tr|F1MI25-1|A0A3Q1M1T1_BOVIN Computationally mapped isoform of Zinc finger protein 40 OS=Bos taurus OX=9913 GN=HIVEP1 PE=4 SV=4 CANONICAL=A0A3Q1M1T1-1" }, "locus": { "chromosome": "23", "start_pos": 44410631, "end_pos": 44282432, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001655.8", "url": "https://www.ensembl.org/id/ENSBTAT00000001655.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001655.7", "url": "https://www.ensembl.org/id/ENSBTAP00000001655.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2231, "start_aa": "Thr", "end_pos": 2231, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2231", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 346, "start_aa": "Thr", "end_pos": 346, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr346", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 363, "start_aa": "Thr", "end_pos": 363, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr363", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:529115", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529115", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M9PBC6-1", "protein_name": "Zinc finger protein 40", "gene_name": "hivep1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNRQREIEETLSINTDKIEEAQKEFKDPKGAHKDTNESTGRNSESIKGLKRKKVVAQNQLKKIPKSPVKKQSQTKKSISSNISSKEATPSSFPSSPSHGSPKPEDAEDGPEEVSASRTVKVEQEEISTSEPQALSHKGAAAEPCVAEPVQTESWCGDSCNKSTQSPSHTSAPLEVLLKAMEPDFIDFTERKNSSPIGHLGKSASNPVTYSDYAVAMPAVNFNIQSQNSFMQPFNAAKQYYSSVASTGQHITQPYMSGNRQQEKPGVQKSYSVGPSLTLMHAPVPSGSGGFPQSQPPVVQTCQSLSATVPNSIQVPVTPGYNPVQMTTVVNFGASQVSDISAKDQKPKKQGKYVCEYCKRACAKPSVLLKHIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHAIKLGLVKDSGSGSLSQESDKGLATHSDVDESGDSDEESSAADLDADSSQSSLTALSESSLQSASMIQGSQAESEHSLVFENLKPSATQRGCEPKVTAALPKVVVHPVNVSPLRADSPRVTDSAPEQATAQRQRDFQPTNLRSNVTVLSSLKEVDCTSPPQDSVSDDEDQHCKSPLGGSHAQLQRQQATDYSQQAQVKCLLSPRSLGSTDSGYFSRSESADQAMSPPSPFVKITPPGDTDITKTPHIPPCPVVAAVMHVATIEKPRVPSGQMRPPLETKALSLEERISKLISDNEAVVDDKQLDSVKPRRTSLSRRGSIDSPKSYIFKDSFQFDLKPPVRRSSSNSDIPKSPFTPTDKSKQVFLLSVPSQYPAMECLPITRSNSMPTTPGQSALFPNVTTQPHQLRICQSFDDKISSLNDDVFSSAPSTPNPAVHPRTLVRQIAVEDLSTNDGHVLIQVHSMDESHHGPSITHELRSKSFEHATERNRKPQQNKGTMYECETCRNRYRKLENFENHKKFYCSELHGPKNKPMHARETEHEVFGRGIQQPLLNRNAVITGNVEQPLMLRKRRKIKSVGDDDDQSPTETTPPCSRSFDSSQSSTGSIGRTNSHHTQSLGNSAILGQIQIIARAGELQESRLSPIREAQISTPCKERGDLQRQGSGTSVIRHTNSLSRPNSFETSESIDRSSPVDPVEKETKISVKSHTETAVSSSQSYHDRMSTPKCPSQTHEKQSFAIVGDVPPVQQSRLVRQSNIQVPEILVTEEPDRDHETQVVESTEKPAETFSWPQRSESLSKLPTEKLPPKKKRIRLAQMEHSSGESSFESSLSRSLSRDSSLSRCSSISASFDRDDPPRSDSPSRADSVGKPPETQGVPVANNTLGVPGIMRRSTSEQISYTQSSVEISCDYRSKSFDCSSMSPSRPLSPMQTALPKTTQCPPSTLVPLIERRRGPLVRQMSLKIAPEPQIAVKQTTPIQRVPFTNECSGSQPRSVNLNTSALAQCFAVHSGEVSLPKNEQVVQSINLGGKTEQPQVHGLPHPWHQTSRVVAGHVQPLVHMVGGQTDIKKSSDEKNKIFIPKYQMNCPVLKTGQTYSLAGVQGTQIPLPVITIPIANEIKGSHSNDGMQNVYVAQSSYQAVLNKPSIVQPSNAQVDTASHKVPVSAPVPQILITHEHTLASASAVSKVSFPIAPSVNRDSKIGPEIQAQKQPGSVAVQMKNNMKTTDQIQNTEQSILSLGSLHCMQKLASANLCPQESTASSKRMLSPANSLDIAMEKTQKRAKDEHGAACLTDGRSLNYLNSKMSEITRQRKLMLVRQVCTTEPVDSPIETDAPEQLPETLDTEKNTQKPIPQVTTTEVSEQEMESRTPTTTPPARSLPGVQGYPMLENSTLKPQEKPEEQRWSPSKSPLRPPSFQGQVKLASSVSVVNTRDSHRLSFPSLKTATTFTWCFLMKRKPLHVQQMDQRISAYSAWVVNPNNPNPLGLPTKVVMSLFDSKQTSKKIHYTQAKTTTLKSDILTYSGKLKDVLPKVLIQQRSVPSENSGKTKPDTQPVNQKESDRDTSKSEPQRVKIFDGGYKSNEEYVYVRGRGRGKYICEECGIRCKKPSMLRKHIRTHSDIRPFHCTHCNFSFKTKGNLTKHMKSKAHSKKCMEMGVAVGIIEDQDAEDSGDRGRAGSADRQDSDGDDSDGPDDEDNEGEEEDEEDSQAESGLSATPSVSASPQHFSANQADLAPSSLLAQMSISPNPSPALQSQPPPTSDSQTSDTESVAMTSPVSLVRQMSISASCSSPGPNPTSFTSHPTPASESHTSDTDSVHMMSPVSPCRQMSIDYPDFDVPPSPPVSGKGAKLGQDGVSSTISQPASECNANVDRGTQTSSDPLQGSLHFPHAGPLHEPRIGATTHLFSHLPLHSQQPPRSPYSMVPVGGIQLVPAGLAAYSTFVPIQAGPVQLTIPALSVIHRQTGSPLSAPNTSPRPDCSPTQPLVVQEPVSSVLPCFPLGQVAGLQTLGAHQTALQPVGLETLSVVGLANSTQLVPQQSLPLNATLGVQVLAASPAPQCSTASPAQIPGLQILNIALPALIPSLSPLSALSPLPATQDKPRSPEGVASVTLPAQVAGSPPAPLPSASPPTANPGDAAVNAKPCMEVRKVSQNNPSVGSRDTGGAEKTTGMVEKSKAPPQPPSPCSPSLSNERGCNVAHKGSAGEACEVKPRQPVSRQPVTDDYNEASSDDEDRLVIAT", "length": 2636 }, "evidence": [ { "id": "A0A3Q1M1T1", "url": "https://omabrowser.org/oma/group/A0A3Q1M1T1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1M9H4-1", "protein_name": "Zinc finger protein 40", "gene_name": "Hivep1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPRTKQIHPRNLRDKIEEAQKELNGAEVSKKEILEAGVKGASESLKGVKRKKIVAENHLKKIPKSPLRNPLQTKHKQNTEEPLFSALQSAPESHKKHNCVPVKQGRQFTKQNGETPGMTVEASESGDSVSPKKASSPHHRSELRRWRSEGSDPARLSGLDGQRDSSSSSSKTRTDNSECSSPCCSTTPPSYTSTAFDVLLKAMEPELSTLSQKGSSCAVKTEKPRPNRTVRSPSKLKNSSLDAPNPASPELVAESQCSPCTSYPVPVASTQKSEQVAAQRVSHLHSQYDHLVPKPGQQNPQLPGHLGLAGSLTNPHTHENTKLEPIYNIAMTSTVGLASPSSRTQVTPPHQQMDSVSPSSVSPATSTQSPPGPIYSSTHVASVVSQSVEQMCNLLLRDQKPKKQGKYICEYCNRACAKPSVLLKHIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHTIKLGLVLQPEAGGLFLSQECPKALSVHSDIEDSGESDEEGPGDGRQNDPSVRDLQPVQIMKMPSDPEALPKSIASRADHVVSGFSSQDRPSESQALTELPKVVVHPVSMSPLKTDSVQVASPKPELPSTQSQKDLHAASRLSHSAGVSSLETDETCHQKGDVTLSEGKPEPHSGAAHAQLQRQQATDDPQEQQGKLLLSPRSLGSTDSGYFSRSESADQAMSPPTPFARTFPTTDPDPAKNSGPAGPRISAPAPAALAPGEKSSVVAGQMRPPLATKTLEERISKLISDNEALVDDKQLDSVKPRRTSLSRRGSIDSPKSYIFKDSFQFDLKPMGRRTSSSSDIPKSPFTPTEKSKQVFLLSVPSLDCLPITRSNSMPTTGYSAVPANIIPPPPPLRGSQSFDDKIGTFYDDVFVSGPNPSMPPSGHHRPLVRQAAVEDSTASENHVLGSGQSVDESCQGCPASSEPGPVQSKAANTPHLEKKKSHQGRGTMFECETCRNRYRKLENFENHKKFYCSELHGPKTKVAAREPEHGLAPGGVQPQVLHYRVAAPTAVWEQTPQIRKRRKMKSVGDDEDLQPRESGRSPESAEALQLQPVPGSAPSPSKQAPATAGDQAHRGVQLQSSPVQLVARVPEQALPLKQCPVVEQQLNSATQDRIEVQRQAGGISVIQHTNSLSRPSSFDKLEPLEGGTAFSLQELGRAGMPGALKVIGMPPEEGHPPRDATHQIALSRESARKIPSERFVLGQPLRLVRQHNIQVPEILVTEEPDRDLEAQSHDEEKSEKFTWPQRSETLSKLPTEKLPPKKKRLRLAEIEHSSTESSFESTLSRSLSRESSLSHASSFSASLDVEDISKVELSPKTDFPSKAEFLFIPLGSNTLSVPGSHREMRRAASEQISCVPTLMEVSDFRSKSFDCGSIAPSHVVPALVEPQPSNSPSGVGGTGHVPLLERRRGPLTRQISLNIASDSPLSPGSVSALQTIVLPGVNAIPLQALRPPDVASADLPAHTVPSQALAKDLQAEMSSCSSTDTFPPQQLFGAHLLNKTNMPLSHQNTPLPLPVSVQGGKPGAPPPAGTSSTGDGSFAPKYQLQCQAFTSGRGCSSSPLHSLPNPVLPDQTAADPCTASVALSAKAVDPVSKSYPLPSLELGLPSDQVQKRLPSFVLPVLQPRDVPVYCLSTVTSLPQILVTHDLSNTPICQTNQSIVPVSEEQNPMPKSQNYLQNALPTPEKDLACKTVLSEMGQNAPVSESSATVQKVSAGRLSPQQESSASSKRMLSPANSLDIAMEKHQKRAKDENGAVCSTNIRPLELPSSRANEGHKQKKPVLVRQLCTVEPLEGTALEQDPGSASGKSSRNADSTQVLSTDSLSSRHSMFAVPDHVSEFQEFKNTKLSTSLTPTVGSSHIPLESACVLPLKSRDDNQEKGSSGVQNEENKVIQGQRQPPIPGLSVLSSSDTQQPSFPSLKTATSFTWCYLLRQKSLPLAQSDQKTSAYAGWTVSPSNPNPLGLPTKVALSLLNSKQKTGKSLYCQAITTHSKSDLVVYSSKWKNNLSKRALGNQKATIVEFSNKDDSEINSEQDKENSLIKSEPRRIKIFDGGYKSNEDYVYVRGRGRGKYICEECGIRCKKPSMLKKHIRTHTDVRPYHCTYCNFSFKTKGNLTKHMKSKAHSKKCVDLGISVGLIDEQDTEESDEKQRFGCERSGFDLEESDGPDEDDNDNEEDDDDSQAESGLSAAPSVTASPQHLPSRSGLQDPGSVEEDLRVSSCFSGVHTDPMDILPRALLTKMTVLSTVQIDPNRTDLTAKARQNTGKDELELAPPVDTPISPEVTPRSPGHQMSVHYSESDALRSPAAGNTVASIQDSPSVGLPPATIAQLNPQPAARISSSVSPHPESQEPKQQITLQPSPGLPSPQTHLFSHLPLHSQQQSRTPYNMVPVGGIHVVPAGLTYSTFVPIQAGPMQLTIPAVSVIHRTVGTPVDTITEVSGATNRPTGVAELSSVVPCIPIGQIHVPGLQNLSPPALQSLSSLGMETVNIVGLANATVGPQVHPPGLALNAVGLQVLANAPAQSSPATQTHIPGLQILNIALPTLIPSVGPVAVGTAGTPETATSNSKTVEPQTPAGQGHSAEPPQRLPEGPQETPQTVPGPSVDHARPDGSSKMDTKKVASASHVLPGRSSAQAQPAPIPEALQKIVASGPTSLPTDRPAPRPPVPHRQPIVHFSDVSSDDDEDRLVIAT", "length": 2691 }, "evidence": [ { "id": "A0A3Q1M1T1", "url": "https://omabrowser.org/oma/group/A0A3Q1M1T1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P15822-1", "protein_name": "Zinc finger protein 40", "gene_name": "HIVEP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRTKQIHPRNLRDKIEEAQKELNGAEVSKKEILQAGVKGTSESLKGVKRKKIVAENHLKKIPKSPLRNPLQAKHKQNTEESSFAVLHSASESHKKQNYIPVKNGKQFTKQNGETPGIIAEASKSEESVSPKKPLFLQQPSELRRWRSEGADPAKFSDLDEQCDSSSLSSKTRTDNSECISSHCGTTSPSYTNTAFDVLLKAMEPELSTLSQKGSPCAIKTEKLRPNKTARSPPKLKNSSMDAPNQTSQELVAESQSSCTSYTVHMSAAQKNEQGAMQSASHLYHQHEHFVPKSNQHNQQLPGCSGFTGSLTNLQNQENAKLEQVYNIAVTSSVGLTSPSSRSQVTPQNQQMDSASPLSISPANSTQSPPMPIYNSTHVASVVNQSVEQMCNLLLKDQKPKKQGKYICEYCNRACAKPSVLLKHIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHTIKLGLVLQPDAGGLFLSHESPKALSIHSDVEDSGESEEEGATDERQHDLGAMELQPVHIIKRMSNAETLLKSSFTPSSPENVIGDFLLQDRSAESQAVTELPKVVVHHVTVSPLRTDSPKAMDPKPELSSAQKQKDLQVTNVQPLSANMSQGGVSRLETNENSHQKGDMNPLEGKQDSHVGTVHAQLQRQQATDYSQEQQGKLLSPRSLGSTDSGYFSRSESADQTVSPPTPFARRLPSTEQDSGRSNGPSAALVTTSTPSALPTGEKALLLPGQMRPPLATKTLEERISKLISDNEALVDDKQLDSVKPRRTSLSRRGSIDSPKSYIFKDSFQFDLKPVGRRTSSSSDIPKSPFTPTEKSKQVFLLSVPSLDCLPITRSNSMPTTGYSAVPANIIPPPHPLRGSQSFDDKIGAFYDDVFVSGPNAPVPQSGHPRTLVRQAAIEDSSANESHVLGTGQSLDESHQGCHAAGEAMSVRSKALAQGPHIEKKKSHQGRGTMFECETCRNRYRKLENFENHKKFYCSELHGPKTKVAMREPEHSPVPGGLQPQILHYRVAGSSGIWEQTPQIRKRRKMKSVGDDEELQQNESGTSPKSSEGLQFQNALGCNPSLPKHNVTIRSDQQHKNIQLQNSHIHLVARGPEQTMDPKLSTIMEQQISSAAQDKIELQRHGTGISVIQHTNSLSRPNSFDKPEPFERASPVSFQELNRTGKSGSLKVIGISQEESHPSRDGSHPHQLALSDALRGELQESSRKSPSERHVLGQPSRLVRQHNIQVPEILVTEEPDRDLEAQCHDQEKSEKFSWPQRSETLSKLPTEKLPPKKKRLRLAEIEHSSTESSFDSTLSRSLSRESSLSHTSSFSASLDIEDVSKTEASPKIDFLNKAEFLMIPAGLNTLNVPGCHREMRRTASEQINCTQTSMEVSDLRSKSFDCGSITPPQTTPLTELQPPSSPSRVGVTGHVPLLERRRGPLVRQISLNIAPDSHLSPVHPTSFQNTALPSVNAVPYQGPQLTSTSLAEFSANTLHSQTQVKDLQAETSNSSSTNVFPVQQLCDINLLNQIHAPPSHQSTQLSLQVSTQGSKPDKNSVLSGSSKSEDCFAPKYQLHCQVFTSGPSCSSNPVHSLPNQVISDPVGTDHCVTSATLPTKLIDSMSNSHPLLPPELRPLGSQVQKVPSSFMLPIRLQSSVPAYCFATLTSLPQILVTQDLPNQPICQTNHSVVPISEEQNSVPTLQKGHQNALPNPEKEFLCENVFSEMSQNSSLSESLPITQKISVGRLSPQQESSASSKRMLSPANSLDIAMEKHQKRAKDENGAVCATDVRPLEALSSRVNEASKQKKPILVRQVCTTEPLDGVMLEKDVFSQPEISNEAVNLTNVLPADNSSTGCSKFVVIEPISELQEFENIKSSTSLTLTVRSSPAPSENTHISPLKCTDNNQERKSPGVKNQGDKVNIQEQSQQPVTSLSLFNIKDTQQLAFPSLKTTTNFTWCYLLRQKSLHLPQKDQKTSAYTDWTVSASNPNPLGLPTKVALALLNSKQNTGKSLYCQAITTHSKSDLLVYSSKWKSSLSKRALGNQKSTVVEFSNKDASEINSEQDKENSLIKSEPRRIKIFDGGYKSNEEYVYVRGRGRGKYICEECGIRCKKPSMLKKHIRTHTDVRPYHCTYCNFSFKTKGNLTKHMKSKAHSKKCVDLGVSVGLIDEQDTEESDEKQRFSYERSGYDLEESDGPDEDDNENEDDDEDSQAESVLSATPSVTASPQHLPSRSSLQDPVSTDEDVRITDCFSGVHTDPMDVLPRALLTRMTVLSTAQSDYNRKTLSPGKARQRAARDENDTIPSVDTSRSPCHQMSVDYPESEEILRSSMAGKAVAITQSPSSVRLPPAAAEHSPQTAAGMPSVASPHPDPQEQKQQITLQPTPGLPSPHTHLFSHLPLHSQQQSRTPYNMVPVGGIHVVPAGLTYSTFVPLQAGPVQLTIPAVSVVHRTLGTHRNTVTEVSGTTNPAGVAELSSVVPCIPIGQIRVPGLQNLSTPGLQSLPSLSMETVNIVGLANTNMAPQVHPPGLALNAVGLQVLTANPSSQSSPAPQAHIPGLQILNIALPTLIPSVSQVAVDAQGAPEMPASQSKACETQPKQTSVASANQVSRTESPQGLPTVQRENAKKVLNPPAPAGDHARLDGLSKMDTEKAASANHVKPKPELTSIQGQPASTSQPLLKAHSEVFTKPSGQQTLSPDRQVPRPTALPRRQPTVHFSDVSSDDDEDRLVIAT", "length": 2718 }, "evidence": [ { "id": "A0A3Q1M1T1", "url": "https://omabrowser.org/oma/group/A0A3Q1M1T1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q03172-1", "protein_name": "Zinc finger protein 40", "gene_name": "Hivep1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRTKQIHPRNLRDKIEEAQKELNGAEVSKKEVLEAGVKGTSESLKGVKRKKIVAENHLKKIPKSPLRNPLQTKHKQNTEEPPFSVLPSASESHKKHNCVPAKQGRQFTKQNGETPGMTAESSESGDLVSPKKTSSPHQRSELRRWRSEGSDPTRLSGLDGQRDSSSSSSKARTDNSECSSPCCSTTPPSYTSTAFDVLLKAMEPELSTLSQKGSSCAIKTEKLRPNKTVRSPSKLKNSSLDAPNATSPDLVVESPCPPCTSYPVHVASTQKSEQVAAQCVSHLYSSQDHLVPKLSQQNQQLPGHLGFTGSLTNLHTLESTKLEPIYNTAVTSTVGLTSPSTRTQVTPPHQQMDSVSPLSVSPASSTQSPPGPIYSSAHVASVVSQSVEQMCSLLLRDQKPKKQGKYICEYCNRACAKPSVLLKHIRSHTGERPYPCVTCGFSFKTKSNLYKHKKSHAHTIKLGLVLQPEAGGLFLSQECPKALSVHSDIEDSGESDEEGLADGRQNNPCVKDLQPVQTMKTVSNPESLPKLIPSNSDHVVRGFSSQDRPSDSQAPTELPKVVVHPVSMPPLKTDCLQVANPNPELPSPQSPRDLHVASILSHSASVSSLEMDESCHQKGDVIQSEGKPDSHSGTAHAQLQRQQATEDPQEQQGKLLLSPRSLGSTDSGYFSRSESADQAVSPPTPFARTFPTMDPDPAKNGGAPGPRISAPAPSALATGEKSSVVTGQMRPPLATKTLEERISKLISDNEALVDDKQLDSVKPRRTSLSRRGSIDSPKSYIFKDSFQFDLKPMGRRTSSSSDIPKSPFTPTEKSKQVFLLSVPSLDCLPITRSNSMPTTGYSAIPANIIPPPPSLRGSQSFDDKIGTLYDDVFVSGPNPSMPPSGHHRPLVRQAAVEDSTASESHVPGSGQSVDESCQGCPSSSEAGPVQSKAAQTPHLEKKKSHQGRGTMFECETCRNRYRKLENFENHKKFYCSELHGPKTKAAVREAEHGPAPGGAQPQVLHYRVAAPTAVWEQTPQIRKRRKMKSVGDEEDLQPHESGRSPESADALQLQPVPGAAPSPSKHTSATAADQAHRGVQLVARGPERALPLKQCPMVEQQLNAAAQDKMEVKRQGGGISVIQHTNSLSRPNSFDKPEPLEGGITFSLQELGRTGMPGALKVIGMAPEEGHPPQDAMHQTALSHNLRGEPRESARKIPSERYVLGQPLRLVRQHNIQVPEILVTEEPDRDLEAQSHDEEKSEKFTWPQRSETLSKLPTEKLPPKKKRLRLAEIEHSSTESSFESTLSRSLSRESSLSHASSFSASLDLEDISKVELAPKIDFPSKAEFLLIPLGSNTLSVPGSHREMRRAASEQISCVPTLMEVSDFRSKSFDCGSIAPSHVVPALVESQPSYSPSAVGGTAHVPLLERRRGPLIRQISLNIASDSHLSPGSAAALQTIVLPSVNTVPFQAPRLPDMASADCPAHTVHPQALAKDLQAEISSSSSTDTFPPQQLFGAHLLNKTNTSLSHQNTPLPLPVSAQGGKPDAAPTACVSSTGEGSFAPKYQLQCQAFTSDQGCSAPLRSSPNQVLPGQAGADPCPASEAPPAKAADPMAKPCPLPPLELGLPRDEVLQKQLPSFVLPVPQKRNVTVDCFTPVTSLPQILVTQDLPNMPICQTNQSLVPVSEEQNSMPKSQNYLQNASPTPEKELACKTVLPEVGQSVPVSESSPTVQKVSVGRLSPQQESSASSKRMLSPANSLDIAMEKHQKRAKDENGAVCSTNIRALELPSSRANESHKQKKPVLVRQLCTTEPLEGAALEQGACSASGRSSNKAANLTQVLPTDSLSSRPSTFAVTDHVNELQEFKNTKVSTSLTPTVGSFPAPSESACVLPLKSIDNNQEKGSPGVRHEENKVIQGQRPPLVSGLSLVSSSDTQQPSFPSLKTATSFTWCYLLRQKALPLAQNDQKTSAYTGWTVSSSNPNPLGLPTKVALSLLNSKQKTGKSLYCQAITTHSKSDLVVYSSKWKNNLSKRALGNQKATVVEFSNKDDSEINSEQDKENSLIKSEPRRIKIFDGGYKSNEDYVYVRGRGRGKYICEECGIRCKKPSMLKKHIRTHTDVRPYHCSYCNFSFKTKGNLTKHMKSKAHSKKCVDLGVSVGLIDEQDTEESDEKQRFGCERSGYDLEESDGPDEDDNDNEEDDDDSQAESGLSAAPSVTASPQHLPSRSGLQDPGSVEEELRVSSCFSGVHTDPMDILPRALLTKMTVLSTVQSSPNRTDLPAKARQSTEKDEHEQAPPADTPRSPGHQLSVHSSESDVLRSPAAGNPAAGSPGAAVQDSSVGLPPAVAQLNPQPAARISSSVSPHPDSQDQKQQIILQPPPGLPSPQTHLFSHLPLHSQQQSRTPYNMVPVGGIHVVTAGLTYSTFVPIQAGPMQLTIPAVSVIHRTVGTSGDTITEASGSPNRPTGVAELSSVVPCIPIGQIHVPGLQNLSPPALQSLTSLGMETVNLVGLANATVGPQGHPPGLALNAVGLQVLANAPAQSSPAPPAHIQGLQILNIALPTLIPSVGPVAVGTTGTPETTAPNSKAMELQMPAGQGHSAEPPQGSPEGPQETPQTVSGPSADHARPEDSTKMDTKKGPSAGHVLPGRSPAQAQPAPTPEALQKVATSAPPSLPTDRAAPRPPVPHRQPIVHFSDVSSDDDEDRLVIAT", "length": 2688 }, "evidence": [ { "id": "A0A3Q1M1T1", "url": "https://omabrowser.org/oma/group/A0A3Q1M1T1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1" } ], "pmid": "" }, { "name": "BMP signaling pathway", "id": "GO:0030509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030509", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M1T1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1T1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1035, "end_pos": 1037, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1660, "end_pos": 1662, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1825, "end_pos": 1827, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2010, "end_pos": 2012, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2110, "end_pos": 2112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2118, "end_pos": 2120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" }, { "start_pos": 375, "end_pos": 377, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 346, 363, 2231 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1035, "end_pos": 1037 }, { "start_pos": 1660, "end_pos": 1662 }, { "start_pos": 1825, "end_pos": 1827 }, { "start_pos": 2010, "end_pos": 2012 }, { "start_pos": 2110, "end_pos": 2112 }, { "start_pos": 2118, "end_pos": 2120 }, { "start_pos": 229, "end_pos": 231 }, { "start_pos": 375, "end_pos": 377 }, { "start_pos": 384, "end_pos": 386 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034215", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034215", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050825", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050825", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QRMPMMR", "url": "https://omabrowser.org/oma/group/QRMPMMR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M222", "url": "https://www.orthodb.org/?gene=A0A3Q1M222", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N7X9", "url": "https://www.orthodb.org/?gene=F1N7X9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47640", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47640", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47640:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47640:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005219057", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219057", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M222", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M222", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M222-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M222-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RY47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNL9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7X9", "url": "https://www.uniprot.org/uniprotkb/F1N7X9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7X9-1", "url": "https://www.uniprot.org/uniprotkb/F1N7X9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGAGPAPGLPGAGGPVVPGPGAGIPGKSGEERLKEMEAEMALFEQEVLGAPVTGIPTAVPAVPTVPTVEAMQVPAAPVIRPIIATNTYQQVQQTLEARAAAAATVVPPMVGGPPFVGPVGFGPGDRSHLDSPEAREAMFLRRAAVAPQSATILRPAFVPHVLQRADSALTSAAAGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLGSMAALRPPLEEPATPRELGLGLGLGLKEKEEAVVAAAAGLEEASAAVAVGAGGAPAGPAVIGPSLPLALAMPLPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVPEPLSEDKKKGKPEKLKRCIRTAAGSSWEDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPSFLKAKVIRDKRTGKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKLGLR", "length": 477, "header": "tr|A0A3Q1M222-1|A0A3Q1M222_BOVIN Isoform 1 of RNA-binding protein 42 OS=Bos taurus OX=9913 GN=RBM42 PE=3 SV=1 CANONICAL=A0A3Q1M222-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M222-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M222/entry", "sequence": { "sequence": "MAGAGPAPGLPGAGGPVVPGPGAGIPGKSGEERLKEMEAEMALFEQEVLGAPVTGIPTAVPAVPTVPTVEAMQVPAAPVIRPIIATNTYQQVQQTLEARAAAAATVVPPMVGGPPFVGPVGFGPGDRSHLDSPEAREAMFLRRAAVAPQSATILRPAFVPHVLQRADSALTSAAAGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLGSMAALRPPLEEPATPRELGLGLGLGLKEKEEAVVAAAAGLEEASAAVAVGAGGAPAGPAVIGPSLPLALAMPLPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVPEPLSEDKKKGKPEKLKRCIRTAAGSSWEDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPSFLKAKVIRDKRTGKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKLGLR", "length": 477, "header": "tr|A0A3Q1M222-1|A0A3Q1M222_BOVIN Isoform 1 of RNA-binding protein 42 OS=Bos taurus OX=9913 GN=RBM42 PE=3 SV=1 CANONICAL=A0A3Q1M222-1" }, "locus": { "chromosome": "18", "start_pos": 46363311, "end_pos": 46356049, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086550.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086550.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063810.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063810.1" } ] } }, { "isoform_ac": "A0AAA9RY47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RY47/entry", "sequence": { "sequence": "MAGAGPAPGLPGAGGPVVPGPGAGIPGKSGEERLKEMEAEMALFEQEVLGAPVTGIPTAVPAVPTVPTVEAMQVPAAPVIRPIIATNTYQQVQQTLEARAAAAATVVPPMAKVIRDKRTGKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKLGLR", "length": 181, "header": "tr|A0AAA9RY47-1|A0A3Q1M222_BOVIN Computationally mapped isoform of RNA-binding protein 42 OS=Bos taurus OX=9913 GN=RBM42 PE=3 SV=1 CANONICAL=A0A3Q1M222-1" }, "locus": { "chromosome": "18", "start_pos": 46363311, "end_pos": 46356049, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110781.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110781.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076164.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076164.1" } ] } }, { "isoform_ac": "A0AAA9SNL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNL9/entry", "sequence": { "sequence": "MAGAGPAPGLPGAGGPVVPGPGAGIPGKSGEERLKEMEAEMALFEQEVLGAPVTGIPTAVPAVPTVPTVEAMQVPAAPVIRPIIATNTYQQVQQTLEARAAAAATVVPPMVGGPPFVGPAAGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLGSMAALRPPLEEPATPRELGLGLGLGLKEKEEAVVAAAAGLEEASAAVAVGAGGAPAGPAVIGPSLPLALAMPLPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVPEPLSEDKKKGKPEKLKRCIRTAAGSSWEDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPSFLKAKVIRDKRTGKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKLGLR", "length": 423, "header": "tr|A0AAA9SNL9-1|A0A3Q1M222_BOVIN Computationally mapped isoform of RNA-binding protein 42 OS=Bos taurus OX=9913 GN=RBM42 PE=3 SV=1 CANONICAL=A0A3Q1M222-1" }, "locus": { "chromosome": "18", "start_pos": 46363311, "end_pos": 46356049, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135662.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135662.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085553.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085553.1" } ] } }, { "isoform_ac": "A0AAA9SPM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPM3/entry", "sequence": { "sequence": "MAGAGPAPGLPGAGGPVVPGPGAGIPGKSGEERLKEMEAEMALFEQEVLGAPVTGIPTAVPAVPTVPTVEAMQVPAAPVIRPIIATNTYQQVQQTLEARAAAAATVVPPMVGGPPFVGPVGFGPGDRSHLDSPEAREAMFLRRAAAGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLGSMAALRPPLEEPATPRELGLGLGLGLKEKEEAVVAAAAGLEEASAAVAVGAGGAPAGPAVIGPSLPLALAMPLPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVPEPLSEDKKKGKPEKLKRCIRTAAGSSWEDPSLLEWDAGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKLGLR", "length": 383, "header": "tr|A0AAA9SPM3-1|A0A3Q1M222_BOVIN Computationally mapped isoform of RNA-binding protein 42 OS=Bos taurus OX=9913 GN=RBM42 PE=3 SV=1 CANONICAL=A0A3Q1M222-1" }, "locus": { "chromosome": "18", "start_pos": 46363311, "end_pos": 46356049, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094982.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094982.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088243.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088243.1" } ] } }, { "isoform_ac": "F1N7X9-1", "url": "https://www.uniprot.org/uniprotkb/F1N7X9/entry", "sequence": { "sequence": "MAGAGPAPGLPGAGGPVVPGPGAGIPGKSGEERLKEMEAEMALFEQEVLGAPVTGIPTAVPAVPTVPTVEAMQVPAAPVIRPIIATNTYQQVQQTLEARAAAAATVVPPMVGGPPFVGPVGFGPGDRSHLDSPEAREAMFLRRADSALTSAAAGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLGSMAALRPPLEEPATPRELGLGLGLGLKEKEEAVVAAAAGLEEASAAVAVGAGGAPAGPAVIGPSLPLALAMPLPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVPEPLSEDKKKGKPEKLKRCIRTAAGSSWEDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPSFLKAKVIRDKRTGKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKLGLR", "length": 455, "header": "tr|F1N7X9-1|A0A3Q1M222_BOVIN Computationally mapped isoform of RNA-binding protein 42 OS=Bos taurus OX=9913 GN=RBM42 PE=3 SV=2 CANONICAL=A0A3Q1M222-1" }, "locus": { "chromosome": "18", "start_pos": 46363311, "end_pos": 46356049, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017884.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017884.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017884.4", "url": "https://www.ensembl.org/id/ENSBTAP00000017884.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8D1WAD4-1", "protein_name": "RNA-binding protein 42", "gene_name": "RBM42", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGAGPTPGLPGTGGPVVPGPGTGIPGKSGEERLKEMEAEMALFEQEVLGAPVTGIPAAVPAVPTVPTVEAMQVPTAPVIRPIIATNTYQQVQQTLEARAAAAATVVPPMVGGPPFVGPVGFGPGDRSHLDSPEAREAMFLRRAAVAPQRAPILHPAFIPHVLQRADSALSSAAAGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLSSMAALRPPLEEPATPRELGLGLGLGLKEKEEAVVAAAAGLEEASAAVAVGAGGAPAGPAVIGPSLPLALAMPLPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVPEPLGEDKKKGKPEKLKRCIRTAAGSSWEDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPSFLKAKVIRDKRTGKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKLGLR", "length": 477 }, "evidence": [ { "id": "A0A3Q1M222", "url": "https://omabrowser.org/oma/group/A0A3Q1M222/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6AXT7-1", "protein_name": "RNA-binding protein 42", "gene_name": "Rbm42", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASAMAGAGPAPGLPVAGGPVVPGPGVGIPGKSGEERLKEMEAEMALFEQEVLGAPVTGIPTAVPAVPTVEAMQVPPAPVIRPIIATNTYQQVQQTLEARAAAAATVVPPMVGGPPFVGPVGFGPADRSHLDSPEAREAMFLRRAAVAPQRAPILRPAFVPHVLQRADSALSSAAGGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLGSMAALRPPLEEPAAPRDLGLGLGLGLKEKEEAVVAAAAGLEEASAAVAVGAGGAPAGPAVIGPSLPLALAMPLPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVPEPLGEDKKKGKPEKLKRCIRTAAGSSWEDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPSFLKAKVIRDKRTGKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKLGLR", "length": 478 }, "evidence": [ { "id": "A0A3Q1M222", "url": "https://omabrowser.org/oma/group/A0A3Q1M222/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91V81-1", "protein_name": "RNA-binding protein 42", "gene_name": "Rbm42", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASAMAGAGPAPGLPVAGGPVVPGPGVGIPGKSGEERLKEMEAEMALFEQEVLGAPVTGIPTAVPAVPTVEAMQVPPAPVIRPIIATNTYQQVQQTLEARAAAAATVVPPMVGGPPFVGPVGFGPADRGHLDSPEAREAMFLRRAAVAPQRAPILRPAFVPHVLQRADSALSSAAGGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLGSMAALRPPLEEPAAPRELGLGLGLGLKDKEEAVVAAAAGLEEASAAVAVGAGGAPAGPAVIGPSLPLALAMPLPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVPEPLGEDKKKGKPEKLKRCIRTAAGSSWEDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPSFLKAKVIRDKRTGKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKLGLR", "length": 478 }, "evidence": [ { "id": "A0A3Q1M222", "url": "https://omabrowser.org/oma/group/A0A3Q1M222/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BTD8-1", "protein_name": "RNA-binding protein 42", "gene_name": "RBM42", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGAGPAPGLPGAGGPVVPGPGAGIPGKSGEERLKEMEAEMALFEQEVLGAPVPGIPTAVPAVPTVPTVPTVEAMQVPAAPVIRPIIATNTYQQVQQTLEARAAAAATVVPPMVGGPPFVGPVGFGPGDRSHLDSPEAREAMFLRRAAVAPQRAPILRPAFVPHVLQRADSALSSAAAGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLGSMAALRPPLEEPAAPRELGLGLGLGLKEKEEAVVAAAAGLEEASAAVAVGAGGAPAGPAVIGPSLPLALAMPLPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVPEPLGEDKKKGKPEKLKRCIRTAAGSSWEDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPSFLKAKVIRDKRTGKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKLGLR", "length": 480 }, "evidence": [ { "id": "A0A3Q1M222", "url": "https://omabrowser.org/oma/group/A0A3Q1M222/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M222", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M222" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M222", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M222" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M222", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M222" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M222-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 477, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M222-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M222" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M222" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 378, "end_pos": 456, "start_aa": "Phe", "end_aa": "Trp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 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"Protein Classification" ] }, { "id": "PF00841", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00841", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M259", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M259", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M259-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M259-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D5K1V1", "url": "https://www.uniprot.org/uniprotkb/D5K1V1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D5K1V1-1", "url": "https://www.uniprot.org/uniprotkb/D5K1V1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVRCHVKSPTESPPGQQGSGQQGETEHPDQARELRPEDIPVYGRTHRGRYHYRHRSHTRRRPYRRRRRRACRHRRRRRGAAGPPCAPIPGTPQASRQGSGCRRMRRRRRRCRRQL", "length": 115, "header": "tr|A0A3Q1M259-1|A0A3Q1M259_BOVIN Isoform 1 of Protamine-2 OS=Bos taurus OX=9913 GN=PRM2 PE=3 SV=1 CANONICAL=A0A3Q1M259-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M259-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M259/entry", "sequence": { "sequence": "MVRCHVKSPTESPPGQQGSGQQGETEHPDQARELRPEDIPVYGRTHRGRYHYRHRSHTRRRPYRRRRRRACRHRRRRRGAAGPPCAPIPGTPQASRQGSGCRRMRRRRRRCRRQL", "length": 115, "header": "tr|A0A3Q1M259-1|A0A3Q1M259_BOVIN Isoform 1 of Protamine-2 OS=Bos taurus OX=9913 GN=PRM2 PE=3 SV=1 CANONICAL=A0A3Q1M259-1" }, "locus": { "chromosome": "25", "start_pos": 9934119, "end_pos": 9933631, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075362.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075362.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062174.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062174.1" } ] } }, { "isoform_ac": "D5K1V1-1", "url": "https://www.uniprot.org/uniprotkb/D5K1V1/entry", "sequence": { "sequence": "MVRCHVKSPTESPPGQQGSGQQGETEHPDQARELRPEDIPVYGRTHRGRYHYRHRSHTRRRPYRRRRRRACRHRRRRRGCRRMRRRRRRCRRQL", "length": 94, "header": "tr|D5K1V1-1|D5K1V1_BOVIN Computationally mapped isoform of Protamine-2 OS=Bos taurus OX=9913 GN=PRM2 PE=3 SV=1 CANONICAL=A0A3Q1M259-1" }, "locus": { "chromosome": "25", "start_pos": 9934119, "end_pos": 9933631, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037464.4", "url": "https://www.ensembl.org/id/ENSBTAT00000037464.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037295.3", "url": "https://www.ensembl.org/id/ENSBTAP00000037295.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "I3LIV5-1", "protein_name": "Protamine-2", "gene_name": "PRM2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVRCRVRSPSESPQQGSGQQRENERQDQDQELRPEDVPVYGRTHRGRYHYRHRSHTRRRRRSCRRRRRRACRHRRHRRGCRRIRRRRRCRRRL", "length": 93 }, "evidence": [ { "id": "A0A3Q1M259", "url": "https://omabrowser.org/oma/group/A0A3Q1M259/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P04554-1", "protein_name": "Protamine-2", "gene_name": "PRM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVRYRVRSLSERSHEVYRQQLHGQEQGHHGQEEQGLSPEHVEVYERTHGQSHYRRRHCSRRRLHRIHRRQHRSCRRRKRRSCRHRRRHRRGCRTRKRTCRRH", "length": 102 }, "evidence": [ { "id": "A0A3Q1M259", "url": "https://omabrowser.org/oma/group/A0A3Q1M259/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P07978-1", "protein_name": "Protamine-2", "gene_name": "Prm2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVRYRMRSPSEGPHQGPGQDHEREEQGQGQGLSPERVEDYGRTHRGHHHHRHRRCSRKRLHRIHKRRRSCRRRRRHSCRHRRRHRRGCRRSRRRRRCRCRKCRRHHH", "length": 107 }, "evidence": [ { "id": "A0A3Q1M259", "url": "https://omabrowser.org/oma/group/A0A3Q1M259/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P11248-1", "protein_name": "Protamine-2", "gene_name": "Prm2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVRYRMRSPSEGQHQGPGQDHEREEQGQGQELSPERVEDYGRTERGHHHRHRRCKRLHRIHKRRRSCRRRRRHSCRHRRRHRRGCRRSRRRRSCRCRKCRWHYY", "length": 104 }, "evidence": [ { "id": "A0A3Q1M259", "url": "https://omabrowser.org/oma/group/A0A3Q1M259/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M259", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M259" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M259", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M259" } ], "pmid": "" }, { "name": "nucleosome", "id": "GO:0000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000786", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M259", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M259" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M259", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M259" } ], "pmid": "" }, { "name": "chromosome condensation", "id": "GO:0030261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030261", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M259", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M259" } ], "pmid": "" }, { "name": "nucleus organization", "id": "GO:0006997", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006997", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M259", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M259" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M259-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 115, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M259-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M259" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M267-1", "uniprot_ac": "A0A3Q1M267", "uniprot_id": "A0A3Q1M267_BOVIN", "mass": { "chemical_mass": 47086.0, "monoisotopic_mass": 47086.0 }, "refseq": { "ac": "XP_002685447", "name": "speckle-type POZ protein-like isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685447" }, "gene_names": [ { "name": "SPOPL", "type": "recommended", "evidence": [ { "id": "A0A3Q1M267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267" } ] }, { "name": "SPOPL", "type": "synonym", "evidence": [ { "id": "XP_002685447", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685447" } ] } ], "protein_names": [ { "name": "Speckle type BTB/POZ protein like", "type": "synonym", "evidence": [ { "id": "A0A3Q1M267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267/entry#names_and_taxonomy" } ] }, { "name": "speckle-type POZ protein-like isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002685447", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685447" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M267", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPOPL", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267", "locus": { "chromosome": "2", "start_pos": 58562827, "end_pos": 58612770, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013455", "url": "https://www.ensembl.org/id/ENSBTAG00000013455" } ] } } ], "crossref": [ { "id": "A0A3Q1M267", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M267", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013455", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013455", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18343", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18343", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18519", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18519", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510817", "url": "https://www.ncbi.nlm.nih.gov/gene/510817", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008974", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008974", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056423", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056423", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510817", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510817", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M267", "url": "https://www.orthodb.org/?gene=A0A3Q1M267", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MAL9", "url": "https://www.orthodb.org/?gene=A0A3Q1MAL9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B7Y9", "url": "https://www.orthodb.org/?gene=E1B7Y9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24413", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24413", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22486", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22486", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24570", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24570", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5632684", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5632684", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002685447", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685447", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M267", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M267-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAL9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAL9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Y9", "url": "https://www.uniprot.org/uniprotkb/E1B7Y9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B7Y9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Y9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKYSPVWDIAYILEDCNKVAMSREPTPPLSGDMSIGPIAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSSPSDKMKWCLRVNPKGLDDESKDYLSLYLLLVSCPKSEVRAKFKFSLLNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGHTNTNMLKVPECRLAEDLGNLWENTRFTDCSFFVRGQEFKAHKSVLAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCSNLSVENVADTLVLADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNSNQAADIMETSGWKSMIHSHPHLVAEAFRALASAQCPQFGIPRKRLKQS", "length": 413, "header": "tr|A0A3Q1M267-1|A0A3Q1M267_BOVIN Isoform 1 of Speckle type BTB/POZ protein like OS=Bos taurus OX=9913 GN=SPOPL PE=3 SV=1 CANONICAL=A0A3Q1M267-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M267-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267/entry", "sequence": { "sequence": "MVKYSPVWDIAYILEDCNKVAMSREPTPPLSGDMSIGPIAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSSPSDKMKWCLRVNPKGLDDESKDYLSLYLLLVSCPKSEVRAKFKFSLLNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGHTNTNMLKVPECRLAEDLGNLWENTRFTDCSFFVRGQEFKAHKSVLAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCSNLSVENVADTLVLADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNSNQAADIMETSGWKSMIHSHPHLVAEAFRALASAQCPQFGIPRKRLKQS", "length": 413, "header": "tr|A0A3Q1M267-1|A0A3Q1M267_BOVIN Isoform 1 of Speckle type BTB/POZ protein like OS=Bos taurus OX=9913 GN=SPOPL PE=3 SV=1 CANONICAL=A0A3Q1M267-1" }, "locus": { "chromosome": "2", "start_pos": 58583468, "end_pos": 58563831, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070707.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070707.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064093.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064093.1" } ] } }, { "isoform_ac": "A0A3Q1MAL9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAL9/entry", "sequence": { "sequence": "MVKYSPVWDIAYILEDCNKVAMSREPTPPLSGDMSIGPIAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSSPSDKMKCCPKSEVRAKFKFSLLNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGHTNTNMLKVPECRLAEDLGNLWENTRFTDCSFFVRGQEFKAHKSVLAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCSNLSVENVADTLVLADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNSNQAADIMETSGWKSMIHSHPHLVAEAFRALASAQCPQFGIPRKRLKQS", "length": 388, "header": "tr|A0A3Q1MAL9-1|A0A3Q1M267_BOVIN Computationally mapped isoform of Speckle type BTB/POZ protein like OS=Bos taurus OX=9913 GN=SPOPL PE=3 SV=2 CANONICAL=A0A3Q1M267-1" }, "locus": { "chromosome": "2", "start_pos": 58583468, "end_pos": 58563831, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087379.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087379.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065633.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065633.2" } ] } }, { "isoform_ac": "E1B7Y9-1", "url": "https://www.uniprot.org/uniprotkb/E1B7Y9/entry", "sequence": { "sequence": "MVKYSPVWDIAYILEDCNKVAMSREPTPPLSGDMSIGPIAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSSPSDKMKWCLRVNPKGLDDESKDYLSLYLLLVSCPKSEVRAKFKFSLLNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGHTNTNMLKVPECRLAEDLGNLWENTRFTDCSFFVRGQEFKAHKSVLAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCSNLSVENVADTLVLADLHSAEQLKAQAIDFINSQAADIMETSGWKSMIHSHPHLVAEAFRALASAQCPQFGIPRKRLKQS", "length": 395, "header": "tr|E1B7Y9-1|A0A3Q1M267_BOVIN Computationally mapped isoform of Speckle type BTB/POZ protein like OS=Bos taurus OX=9913 GN=SPOPL PE=3 SV=3 CANONICAL=A0A3Q1M267-1" }, "locus": { "chromosome": "2", "start_pos": 58583468, "end_pos": 58563831, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017898.4", "url": "https://www.ensembl.org/id/ENSBTAT00000017898.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017898.3", "url": "https://www.ensembl.org/id/ENSBTAP00000017898.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 27, "start_aa": "Thr", "end_pos": 27, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr27", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510817", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510817", "resource": "KEGG Pathway" }, { "id": "R-BTA-5632684", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5632684", "resource": "Reactome", "description": "Hedgehog 'on' state" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M267", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M267", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M267", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M267", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M267", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M267", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267" } ], "pmid": "" }, { "name": "negative regulation of protein ubiquitination", "id": "GO:0031397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031397", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M267", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267" } ], "pmid": "" }, { "name": "regulation of proteolysis", "id": "GO:0030162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030162", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M267", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M267-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 413, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M267-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M267" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 221, "end_pos": 283, "start_aa": "Thr", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1M267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M267" }, { "id": "PS50144", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50144" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MATH", "eco_id": "ECO_0000259", "start_pos": 52, "end_pos": 182, "start_aa": "Lys", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 27 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 190, "end_pos": 192 }, { "start_pos": 317, "end_pos": 319 }, { "start_pos": 61, "end_pos": 63 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": 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{ "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M271-1", "uniprot_ac": "A0A3Q1M271", "uniprot_id": "A0A3Q1M271_BOVIN", "mass": { "chemical_mass": 37208.0, "monoisotopic_mass": 37208.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Magnesium transporter protein 1", "type": "recommended", "evidence": [ { "id": "A0A3Q1M271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M271/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M271", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M271" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M271", "locus": {} } ], "crossref": [ { "id": "A0A3Q1M271", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M271", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000055249", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000055249", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR021149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KVPDYPY", "url": "https://omabrowser.org/oma/group/KVPDYPY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12692", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12692", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12692:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12692:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04756", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04756", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M271", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M271", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M271-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M271-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "GGWRGARKGMMRLGQKVLEEKVRQLMDWTKRDRVMRMNTAAFNHFVLEKPRNYSVIAMFTALQRFRSCAPCKLAVEEFQVLAGSWQFSSAFSNKVFFAMLDFDESPEVFKTLQVKGGPVVLHLPAKSEFTADDIYNFQVRDISAQHMFTWVDDRTGRWMGNFTTRQPIHFHYPFKLGISVALIGGLVYVLKWKRTFIFSKNFWAVLALCFVILMSSGRMWIHIRGAPFAESKTHTGQTHYIQDTYFFQYVAEMYIISLFYMCITLGMVLLSTAATSRMNIIRRKIMSVTGMCLLVIFFSWLLSLVRLKYHVYPFRILMN", "length": 319, "header": "tr|A0A3Q1M271-1|A0A3Q1M271_BOVIN Isoform 1 of Magnesium transporter protein 1 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0A3Q1M271-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M271-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M271/entry", "sequence": { "sequence": "GGWRGARKGMMRLGQKVLEEKVRQLMDWTKRDRVMRMNTAAFNHFVLEKPRNYSVIAMFTALQRFRSCAPCKLAVEEFQVLAGSWQFSSAFSNKVFFAMLDFDESPEVFKTLQVKGGPVVLHLPAKSEFTADDIYNFQVRDISAQHMFTWVDDRTGRWMGNFTTRQPIHFHYPFKLGISVALIGGLVYVLKWKRTFIFSKNFWAVLALCFVILMSSGRMWIHIRGAPFAESKTHTGQTHYIQDTYFFQYVAEMYIISLFYMCITLGMVLLSTAATSRMNIIRRKIMSVTGMCLLVIFFSWLLSLVRLKYHVYPFRILMN", "length": 319, "header": "tr|A0A3Q1M271-1|A0A3Q1M271_BOVIN Isoform 1 of Magnesium transporter protein 1 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0A3Q1M271-1" }, "locus": { "chromosome": "3", "start_pos": 109735608, "end_pos": 109734198, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082077.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082077.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062192.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062192.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VS71-1", "protein_name": "Magnesium transporter protein 1", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEWSWLWRVSLMVVVALVVITPKTPAHRGQEKKILAEKVRQLTYWTKKNRVIRMNDIMFNHFVLETPRNYSVIVMLTALQKFRACLTCEHAAEEFQILADSWQGSRAFSNKVFFALVDFDESPDIFQMLQLMSVPNVLHFSAKRKFTPDDIYHLAERGITAQQMSKWVAERTKRRVVNTRTRQPTDYYYPFKLGISLALIGGLVYVLKWKRKFIFNTHLWAVLALGFVIPMISGHMWTHITEAPFAQSDTHTGRTYYIHEVSYFQLAAEMYIVSLFHVCMTLGMVLLDTAATSRMMVMKRKIISVSSICLFVIFFSWLLSLFRFKEPNYPFRILMD", "length": 337 }, "evidence": [ { "id": "A0A3Q1M271", "url": "https://omabrowser.org/oma/group/A0A3Q1M271/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54N33-1", "protein_name": "Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3", "gene_name": "ost3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MMKSSKVSTILLLLFVVIIGSFCLTYGAPSTTNQKPLTSSEKKLLNDLYDRAKKAGGVVEFKSNLDSKKFVTAQNRPYDLLALFTSSNPKYGCSGCVQLKNQIESFSLSYEPYLNSAGFLEKPIFIVILEVDYNMEVFQTIGLNTIPHLLFIPSGSKPITQKGYAYTGFEQTSSQSISDFIYSHSKIRIEPVKTFYEKYSVQILSFVVFLASVRFLITAYRKRKSPMFWYFLTILLFACVIMGIFYDFIHKPNFYEFDHRQQTYNYFSRGSRSQTVSEGMIMGVSTIAITLIFVFLSDILPNYTNFSSKSKGLLFFMGMSSIIVLLFFQSLAFQIKYYRPLFFIPSVTYHY", "length": 351 }, "evidence": [ { "id": "A0A3Q1M271", "url": "https://omabrowser.org/oma/group/A0A3Q1M271/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "magnesium ion transmembrane transport", "id": "GO:1903830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903830", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M271", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M271" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "oligosaccharyltransferase complex", "id": "GO:0008250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008250", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M271", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M271" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M271-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 319, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M271-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M271" } ], "lectin_list": [], 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"id": "A0A3Q1M282", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M282/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M282", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M282" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDFY2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M282", "locus": { "chromosome": "12", "start_pos": 21198062, "end_pos": 21011872, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008053", "url": "https://www.ensembl.org/id/ENSBTAG00000008053" } ] } } ], "crossref": [ { "id": "A0A3Q1M282", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M282", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008053", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008053", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15718", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15718", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523432", "url": "https://www.ncbi.nlm.nih.gov/gene/523432", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000306", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000306", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M282", "url": "https://www.orthodb.org/?gene=A0A3Q1M282", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46189", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46189", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46189:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46189:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01363", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01363", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M282", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M282", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M282-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M282-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NTT8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NTT8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTT8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6C8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6C8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P6C8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P6C8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q6E3", "url": "https://www.uniprot.org/uniprotkb/F6Q6E3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6Q6E3-1", "url": "https://www.uniprot.org/uniprotkb/F6Q6E3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAEIQPKPLTRKPILLQRVEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSGQYWPSIYHVMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMIQFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDQSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHKVTVGGPSSHSWTKSLSSGTGESRRNLRPPAPCGGETPFPSSRDVQLWCGGTAPYGFHPSDKVQALSYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSPIPLMGFEFEVRVCDSCHEAITDEERAPTATFHDSKHNIVHVHFDATRGWLLTSGTDKVIKLWDMTPVVS", "length": 459, "header": "tr|A0A3Q1M282-1|A0A3Q1M282_BOVIN Isoform 1 of WD repeat and FYVE domain containing 2 OS=Bos taurus OX=9913 GN=WDFY2 PE=4 SV=2 CANONICAL=A0A3Q1M282-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M282-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M282/entry", "sequence": { "sequence": 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{ "isoform_ac": "A0ABI0NTT8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NTT8/entry", "sequence": { "sequence": "MTYAQPTLTVRVWLKRDSGQYWPSIYHVMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMIQFVLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDQSGQVTILKLEQENCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDKVQALSYAQHTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQMWDSKKIGLRQHHCRKCGKAVCGKCSSKRSPIPLMGFEFEVRVCDSCHEAITDEERAPTATFHDSKHNIVHVHFDATRGWLLTSGTDKVIKLWDMTPVVS", "length": 362, "header": "tr|A0ABI0NTT8-1|A0ABI0NTT8_BOVIN Computationally mapped isoform of WD repeat and FYVE domain containing 2 OS=Bos taurus OX=9913 GN=WDFY2 PE=4 SV=1 CANONICAL=A0A3Q1M282-1" }, "locus": { "chromosome": "12", "start_pos": 21197036, "end_pos": 21048616, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153632.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153632.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107035.1", "url": 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[ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050735.4", "url": "https://www.ensembl.org/id/ENSBTAT00000050735.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047399.2", "url": "https://www.ensembl.org/id/ENSBTAP00000047399.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M282", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M282" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M282", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M282" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of fat cell differentiation", "id": "GO:0045600", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045600", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M282", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M282" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M282-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 459, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M282-F1.pdb", "url_external": 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demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-6787618" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M2A1-1" ], "evidence": [ { "id": "R-BTA-6787623", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6787623" } ] }, { "id": "R-BTA-6787642", "name": "GFUS dimer reduces GDP-KDGal to GDP-Fuc", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-6787646" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M2A1-1" ], "evidence": [ { "id": "R-BTA-6787642", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6787642" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-6787618", "participant_name": "GDP-DHDMan [cytosol]", "crossref": [ { "id": "57964", "database": "ChEBI", "url": "" }, { "id": "ZINC000008217042", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-6787646", "participant_name": "GDP-KDGal [cytosol]", "crossref": [ { "id": "746915", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M2A1", "gene_name": "GFUS", "activity": [ { "ec_number": "1.1.1.271", "activity": "GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + NADPH + H(+).", "evidence": [ { "id": "A0A3Q1M2A1", "database": 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{}, "start_pos": 239, "start_aa": "Thr", "end_pos": 239, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr239", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 535, "start_aa": "Thr", "end_pos": 535, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr535", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.", "journal": "The Journal of nutritional biochemistry", "date": "2022-03", "authors": "Qi Hao, Wang Lulu, Zhang Minghui, Wang Zhe, Gao Xuejun, Li Meng", "evidence": [ { "database": "RefSeq", "id": "NP_001192714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192714" } ], "reference": [ { "type": "PubMed", "id": "34843932", "url": "https://glygen.org/publication/PubMed/34843932" } ] } ], "pathway": [ { "id": "bta:540181", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540181", "resource": "KEGG Pathway" }, { "id": "R-BTA-3214858", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214858", "resource": "Reactome", "description": "RMTs methylate histone arginines" }, { "id": "R-BTA-8939243", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8939243", "resource": "Reactome", "description": "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" }, { "id": "R-BTA-9933937", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933937", "resource": "Reactome", "description": "Formation of the canonical BAF (cBAF) complex" }, { "id": "R-BTA-9933946", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9933946", "resource": "Reactome", "description": "Formation of the embryonic stem cell BAF (esBAF) complex" }, { "id": "R-BTA-9934037", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9934037", "resource": "Reactome", "description": "Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YQD7-1", "protein_name": "AT-rich interaction domain 1A", "gene_name": "ARID1A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAQVVPAAASSLGAPAPAELKKAEAQQRDCPPEEAGGEAAAERGGEKQAESEGPPGKELQDAAESNGGGAGAESDLKSSNGNPGPRPAAAAATLNNNLPEPPGGGGISDGVGAPQQQQPPQQPPPSHPAALPPPAYGFGQPYGRGAQAAAAAAAAAAAAAAFHQHGGQQSPGMAALQSGGLEQSYPGPAGAPAGPPPPQNSHGGTEHGFPNHQYNSYYAAGAGRSAGSYPPPPQAYALSSPRGSAQSSAQAAAGAKSPAAAFQQQRFGVMGPSAAGGAGGGGATPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAAGKGPAAVDMVSQYGGGNSQGWAAAPGGAPPRSHHAPMSPGSSGGGGGGQSLGRSQQPSSPMDQMGKMRPQPYGGNNPYTQQQGPQAGPQQGHGYPGQPYGPQTPQRYPMGMQSRTQSTMGSISYAQQIPPYGQQGPNAYGQQSQTPYYNQQSPHPQQQQPPYSQQTPSQTPHSQPSYQQQQQPQSQAPQLQTSQPAYSQQQSQPPHQQSPTPYPQQQSTAQQHQQNQPPYSQQQSQSPYQQQQQTQQTASSALSQQSSSYPQSQPQQQQSAYSQQRFPPPQELSQESFGSQTSSAPSMASSKGQEDMNLNIQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYLQRNPQMPQYSSPQPGSALSPRQSSGGQMHAGMGPYQQNSMGSYGPQAGQYGPQGGYPRQPNYNALSNANYPSPGMGGSMNPMAAGSQMHGQSGVPPYSGLPPGRMSHAAMGNRPYGPNMANMPPQVGTGMCPPPGSMNRKAQEAAAAAMHAAANSIQNRPAGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYPMGGNMANNSAGMAASPEMMGLADVKLTPATKMNNKADGTPKAESKSKKSSSSTTTNEKITKLYELGGEPERKIWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYISVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQTKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQMPPLPGIRSNSVGLQDAFTDGSDPTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYSSMRKAPGSDPFMSSGQGPNSGMGDPYNRAAGPGMGNMAMGQRPHYPYGGPYDRVRTEPGMGPEGNLAAGTPQPNIMPSTSESGMYSPSRYPQQQQQQQRHDSYGNQFSTQGTSSGSPFPSQQTTMYQQQQQNYKRPMDGSYGPPAKRHEGEMYNVPYSAGQGQTQQQLPPAQTQQPSQQQAAQPSPQQDLYNQYGSTYPAADRRSAGGPQNQFPFQFGRDRVSAPPGSNAQQNMPPQMMGGPIQSAPEGPQQGAMWQGRNEIGYSYPNRQSTGSAPQGPAYHGVTRTDDILHSEQRVNHEGPWPSHGNRQPPYGPSAPVPPMTRPPQSNYQTPPSMQNHIPQVSSPAPLPRPLENRTSPSKSPFLHSGMKMQKAGPPVPASHITPAAVQPPMIRRDITFPPGSVEATQPVLKQRRRLTAKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPQRFCRSSASSHEEGEEDEELRSLNNEEEEDDEEEEEAAFSSKDKAPLECSEEKLVSKFDKLPIKIVQKNDPFVVDYSDKLGRVQEFESGLLHWRIGGGDTTEHIQTHFESKMELPMIHKRASCNSVSRKRAAAESNPSTREGEALPSDSSSEKRITATMDDMLSARPSSLSGEEEEAKASETEKESKFPFGISPAQSHRNIKILEDEPHSKDETPLCTIQDWQDSLAKRCICVSNIIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCNKVEWWWDCLEVLRENTLVTLANISGQLDLSPYPESICLPILDGLLHWAVCPSAEAQDPFPTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTLVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQAGLMHMQNAPFESTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS", "length": 2277 }, "evidence": [ { "id": "A0A3Q1M2B9", "url": "https://omabrowser.org/oma/group/A0A3Q1M2B9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2BH40-1", "protein_name": "AT-rich interactive domain-containing protein 1A", "gene_name": "Arid1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAQVAPAAASSLGNPPPPPSELKKAEQQQREEAGGEAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLPEPPGGGGGGGSSSSDGVGAPPHSAAAALPPPAYGFGQAYGRSPSAVAAAAAAVFHQQHGGQQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPPQAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYGGGPQDGGAGKGPADMASQCWGAAAAAAAAAAAVSGGAQQRSHHAPMSPGSSGGGGQPLARTPQSSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSLSYAQQIPPYGQQGPSAYGQQGQTPYYNQQSPHPQQQPPYAQQPPSQTPHAQPSYQQQPQTQQPQLQSSQPPYSQQPSQPPHQQSPTPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPASSSLSQQAAYPQPQPQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYTSPQPGSALSPRQPSGGQMHSGVGSYQQNSMGSYGPQGSQYGPQGGYPRQPNYNALPNANYPNAGMAGSMNPMGAGGQMHGQPGIPPYGTLPPGRMAHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQESAVAMHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYPMGGTMANNSAGMAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQDAFPDGSDPTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGSVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMGTGAPQPNLMPSTPDSGMYSPSRYPPQQQQQQQQQHDSYGNQFSTQGTPSSSPFPSQQTTMYQQQQQNYKRPMDGTYGPPAKRHEGEMYSVPYSAGQGQPQQQQLPAAQSQPASQPQAAQPSPQQDVYNQYSNAYPASATAATDRRPAGGPQNQFPFQFGRDRVSAPPGSSAQQNMPPQMMGGPIQASAEVAQQGTMWQGRNDMTYNYANRQNTGSATQGPAYHGVNRTDEMLHTDQRANHEGPWPSHGTRQPPYGPSAPVPPMTRPPPSNYQPPPSMPNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIAPTPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPGRFTKVYSPAHTEEEEEEHLDPKLEEEEEEGVGNDEEMAFLGKDKPSSENNEEKLVSKFDKLPVKIVQRNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKIELLPSRPYVPCPTPPRKHLTTVEGTPGTTEQEGPPPDGLPEKRITATMDDMLSTRSSTLTDEGAKSAEATKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCDKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS", "length": 2283 }, "evidence": [ { "id": "A0A3Q1M2B9", "url": "https://omabrowser.org/oma/group/A0A3Q1M2B9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D4A3E3-1", "protein_name": "AT-rich interaction domain 1A", "gene_name": "Arid1a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAQVAPAAASSLGNPPPPPSELKKAEQQQREEAGGEAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPPQAYALSSPRGGTPGSGAAAAGSKPPPSSSASASSSSSSFAPQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYGGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHAPMSPGSSGGGGQPLARTPQSSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSLSYAQQIPPYGQQGPSAYGQQGQTPYYNQQSPHPQQQQQPPYSQQPPSQTPHAQPSYQQQPQTQQPQLQSSQPPYSQQPSQPPHQQSQTPYPSQQSTTQQHPQSQPPYSQPQAQAPYQQQQPQQPASSTLSQQAAYPQPQPQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYTSPQPGSALSPRQPSGGQMHSGMGSYQQNSMGSYGPQGSQYGPQGGYPRQPNYNALPNANYPSAGMAGSMNPLGAGGQMHGQPGIPPYGTLPPGRMTHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQESAVAMHVAANSIQNRPPGYPNMNQGGIMGTGPPYGQGINSMAGMINPQGPPYPMGGTMANNSAGMAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQDAFPDGSEPTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGGMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGNVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMGTGAPQPNLMPSTPDSGMYSPSRYPPQQQQQQQQQQQQQQQQQQRHDSYGNQFSTQGTPSSSPFPSQQTTMYQQQQQQNYKRPMDGTYGPPAKRHEGELYSVPYSTGQGQPQQQQLPAAQSQSASQPQAAQPSPQQDVYNQYSNAYPATATAATERRPAGGPQNQFPFQFGRDRVSAPPGSNAQQNMPPQMMGGPIQASAEVAQQGTMWQGRNDMTYNYANRQNTGSAPQGPAYHGVNRTDEMLHTDQRANHEGPWPSHGTRQPPYGPSAPVPPMTRPPPSNYQPPPSMQNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIAPTPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPGRLTKVSSPAPTEEEEEEEHVDPKLEEEEEEGVENDEEMAFLGKDKPPSEKSEEKLVSKFDKLPVKIVQKNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKIELLPSRPCVPSPVPPRKHVTTVEGTPGTTEQEGPPPDGLPEKRITATMDDMLSTRSSTLTDEGTKSTEANKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNAIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCDKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQSPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS", "length": 2291 }, "evidence": [ { "id": "A0A3Q1M2B9", "url": "https://omabrowser.org/oma/group/A0A3Q1M2B9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O14497-1", "protein_name": "AT-rich interactive domain-containing protein 1A", "gene_name": "ARID1A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHAPMSPGSSGGGGQPLARTPQPSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGGLSYTQQIPPYGQQGPSGYGQQGQTPYYNQQSPHPQQQQPPYSQQPPSQTPHAQPSYQQQPQSQPPQLQSSQPPYSQQPSQPPHQQSPAPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPAPSTLSQQAAYPQPQSQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYSSPQPGSALSPRQPSGGQIHTGMGSYQQNSMGSYGPQGGQYGPQGGYPRQPNYNALPNANYPSAGMAGGINPMGAGGQMHGQPGIPPYGTLPPGRMSHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQETAVAMHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYSMGGTMANNSAGMAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQDAFNDGSDSTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGNVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMSTGAPQPNLMPSNPDSGMYSPSRYPPQQQQQQQQRHDSYGNQFSTQGTPSGSPFPSQQTTMYQQQQQNYKRPMDGTYGPPAKRHEGEMYSVPYSTGQGQPQQQQLPPAQPQPASQQQAAQPSPQQDVYNQYGNAYPATATAATERRPAGGPQNQFPFQFGRDRVSAPPGTNAQQNMPPQMMGGPIQASAEVAQQGTMWQGRNDMTYNYANRQSTGSAPQGPAYHGVNRTDEMLHTDQRANHEGSWPSHGTRQPPYGPSAPVPPMTRPPPSNYQPPPSMQNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIAPAPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPGRFSKVSSPAPMEGGEEEEELLGPKLEEEEEEEVVENDEEIAFSGKDKPASENSEEKLISKFDKLPVKIVQKNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKTELLPSRPHAPCPPAPRKHVTTAEGTPGTTDQEGPPPDGPPEKRITATMDDMLSTRSSTLTEDGAKSSEAIKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCNKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS", "length": 2285 }, "evidence": [ { "id": "A0A3Q1M2B9", "url": "https://omabrowser.org/oma/group/A0A3Q1M2B9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8IN94-1", "protein_name": "Trithorax group protein osa", "gene_name": "osa", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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] }, { "id": "A0A3Q1M2F6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2F6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2F6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2F6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "ESPLDWKEIQPAQEGAAGLIIPKNAAEEQKLKLERLMKNPDKAVQIPEKMSEWAPRPPPEFVRDVMGSSAGAGSGEFHVYRHLHRREYQRQDYMDAMAEKQKLDAEFQKRLERNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQSEASSETQEQPSSGSEEASGTEDEEEDAPSFVTGR", "length": 184, "header": "tr|A0A3Q1M2F6-1|A0A3Q1M2F6_BOVIN Isoform 1 of PRKR-interacting protein 1 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0A3Q1M2F6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M2F6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2F6/entry", "sequence": { "sequence": "ESPLDWKEIQPAQEGAAGLIIPKNAAEEQKLKLERLMKNPDKAVQIPEKMSEWAPRPPPEFVRDVMGSSAGAGSGEFHVYRHLHRREYQRQDYMDAMAEKQKLDAEFQKRLERNKIAAEEQTAKRRKKRQKLKEKKLLAKKMKLEQKKQSEASSETQEQPSSGSEEASGTEDEEEDAPSFVTGR", "length": 184, "header": "tr|A0A3Q1M2F6-1|A0A3Q1M2F6_BOVIN Isoform 1 of PRKR-interacting protein 1 OS=Bos taurus OX=9913 GN= PE=3 SV=2 CANONICAL=A0A3Q1M2F6-1" }, "locus": { "chromosome": "5", "start_pos": 13681780, "end_pos": 13681036, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019642.3", "url": "https://www.ensembl.org/id/ENSBTAT00000019642.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063965.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063965.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2F6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2F6" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": 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} ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M2F6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 184, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M2F6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M2F6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { 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"length": 1217, "header": "tr|A0A3Q1M2H1-1|A0A3Q1M2H1_BOVIN Isoform 1 of Multimerin-1 OS=Bos taurus OX=9913 GN=MMRN1 PE=4 SV=1 CANONICAL=A0A3Q1M2H1-1" }, "locus": { "chromosome": "6", "start_pos": 34767204, "end_pos": 34694091, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067311.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067311.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063985.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063985.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-114608", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114608", "resource": "Reactome", "description": "Platelet degranulation" }, { "id": "R-BTA-5173105", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173105", "resource": "Reactome", "description": "O-linked glycosylation" } ], "orthologs": [ { 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"MKEVILLLLLLLQSGSNGFNLTGKLWTTDQGGEALTSDTDLTPSPATVHGYVDAGTTARSPHSEIQTAEESVLQALISASSVKTLENKALKKASNATTSILASQSNGHGDGNSDIDRIRSLQSNARKDPLQQEVSTNQGTAIENRYPKQPSRSAGITNIQRDTNSKPSGFEATRGNNWCAYIHTRLLPTVVVDNLETFSSHRAKPCTWLIGSCAQRSQTTTHQAYRIEHKIVTSLEWKCCPGYSGQNCHPKAQEHQSLLHSIQAESSRTVNEKTPGASQEPSGPALTQKMNESISSQEMKLTSLQKKVDDIAAAMNDLSKMLSSLEGKINEDKGTDFQSFLKGLKSRSINMLVKDIIREQLEVFRREMLENMAQIFKTVSSLSNDLENTKELVKHLNETQEKISLDKDIRPTNLDILELKSHMLQMKEEMTRICDQPMKALQKKQKSLEDNLELQQSRSVIYYESLNRTLNEMRDVHEQLLSTEESSRQNIPSTDEVTEYNITEYMFNLHEKVKKQDLIVLQIYDDLRVQDNKISNLSLALEIQRGSVLGVCDDLLSESRKDFQMQLSGTQESVVVLNRSVSDLVLSLDSKMDKMNEQINDLSYDMEILQPFIEQGPPFSLTSEYEQRIQSEAINEKLENLTTVVNRMSSTIKELSKTQEGLKNKSQAYQELLESHMNECTVEIEDGLNKTMIVINNAIDSIRDNYVQKDTLHALKNETEVCCGRAEKLDSLLAFLSQFQQLNESIWTSLIGKQKHELASQVVPSLSDLPQVESDKTIFHSFGRIYYIINETSSKVDSQKRDIAHLEEKLLDSLEASKDLEVRLLVVESKISKFLANNCVSQKKTKAALTEKEQTALLQLQTLTSRIKALEIKSIRFSNSIPLLNKTAHEAWGLCQDANSSIQKVNASIPVLIKLAQPDIPLLHRGLQELIESVLEIKAGTILTNLTQHVDTSVASAINNVTKLQKQVKPTMKKPAPVKKGAANVTMSLASRSQRNTDNTIDSGQYSACVSSPCQNGGTCISDRQSFVCACRHPFGGVNCSTKLVNDDTLSVDFSKGSYRYAPMVAFFASHTYGMTTPGPIRFNNLDVNYGASFAPATGKFHVPYLGVYVFEYTIESFSPRASGYLVVDGIDKLSFQAENINSNKYNDRVIAGNALLELNYGQEVWLRLATGSIPAKYPPVTTFSGYLLYRT", "length": 1192 }, "evidence": [ { "id": "A0A3Q1M2H1", "url": "https://omabrowser.org/oma/group/A0A3Q1M2H1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B2RPV6-1", "protein_name": "Multimerin-1", "gene_name": "Mmrn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLGLKFLVLLSILWGRVFRLTNTQHSWTAPKDEDASLTPNHASASVSEILSLQVLSATQNPSTQGPAAAERSSEDDVLLQSTSQPSETSTPPEGRHQTPLEKTGTAVVSLPLSLQDKPSIKPSTGAGTVMLANATLKFLQSFSRKSDQQEVSTKSAGDMGNRSARETHLRRSDNSRNQRPSYQKPSFETTRGKNWCAHVHTKLSPTVILDTGSHLPSGRGSCGWYSSGLCSRRSQKTSNAVYRMQHKIVTSLEWRCCPGYIGPNCQLKVEEQQQLAHSNQAESHTAVDQGRAQQQKQDCGDPAMIQKLAEQLSQQERKLSLLQKKVDNASLVADDMRNAYLSLEGKVGEDNSRQFQSFLKALKSKSIEDLLKNIVKEQFKVFQDDMQETTAQIFKTVSSLSEDLESTRQAVLQVNQSFVSSTAQKDFAFMQENQPTWKDITDLKNSIMNIRQEMALTCEKPVKELEAKQAHLEGALRQEHSQIVLYHQSLNETLSKMQEAHIQLLSVLQVSGTENVATEESLNSNVTKYISVLQETASKQGLMLLQMLSDLHVQESKISNLTILLEMEKESARGECEEMLSKCRHDFKFQLKDTEENLHVLNQTLSEVIFPMDIKVDKMSEQLNDLTYDMEILQPLLEQRSSLQHQVIHKPKEATVTRRELQNLIGAINQLNVLTKELTKRHNLLRNEVQSRGEAFERRISEHALETEDGLNKTMTVINNAIDFVQDNYVLKETLSAMTYNPKVCECNQNMDNILTFVSEFQHLNDSIQTLVNNKEKYNFILQIAKALTAIPKDEKLNQLNFQNIYQLFNETTSQVNKCQQNMSHLEENMLSVTKTAKEFETRLQGIESKVTKTLIPYYISFKKGGILSNERDVDLQLKVLNTRFKALEAKSIHLSVSFSLLNKTVRELSMACRNASTGTCGQNALIPRWTKGSLPGSQSSQKSLTELVESIVEIKTQAALSNLTWNVDRLLSDTLANIVKPQKQIKLQKKPNTLKKTVNMTTILIGRTQRNTDTIIHPVAQEHSSCSSFPCQNGGTCISGRSNFICACRHPFMGDTCTVKIKEDDAVAPDFSKGSYRYAPMVAFFVSHTHGMTAPGPILFNDLSVNYGASYNPRTGKFRIPYLGVYIFKYTIESFSAHISGFFVVDGVDKLRFESENADNEIHCDRVLTGDALFELNYGQEVWLRLVKGTIPIKYPPVTTFSGYLLYRT", "length": 1210 }, "evidence": [ { "id": "A0A3Q1M2H1", "url": "https://omabrowser.org/oma/group/A0A3Q1M2H1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D4A3E0-1", "protein_name": "Multimerin-1", "gene_name": "Mmrn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQGQKFLVLLSILWGMVFGLTNTQHSWAVPEDEDSSPTRNSTSAPVSEVLSLQVLSATQNPPPEVPLAPERPSEDTLLQSILQPSESSTPPEGRSQTPTPTEKTGTALASLPLSLQGKPSIKPSSGAETVMLANATLKFLQSFSRKSNQQAVSPKSSGDIGNRSARETHLRRSGNSGNQRPSYQKSSFETTRGKNWCAHVHTKLSPTVILDTHGSNVNSGRGSCGWPSGLCSRRSQKSSNAVYRMQHKIVTSLEWRCCPGYIGPNCQLKAEERQQLVHSNQAESHTAVDQGTAQQQKQDSGDPAMIHKMAEQLSQQERKLMLLQKKVDNVSLAAGDLRNAYLSLEEKVSKDNSKEFQSFLKALKSKSIDDLLKNIVKDQFKVFQDDMQETIAQLFKTVSSLSKDLESTRQAVLQVNQSFVSVTAQKDSALIRENQPTWKDITELKNSITDIRQEMALTCEKPLKELVAKQSHLEGALEQEHSQIVLYHQSLNETLSNMQEAHTQLLSILQVSGTENVATEESVNSNVTKYVSVLQETASKQGLMLLQMLSDLHVQESKISNLTILLEMEKESARGECEEMLSKCRHDFKFQLKDTEENLHVLNQTLTEVIFPMDIKVDKMSEQLNDLTYDMEILQPLLEQRSLLQQQIIHEPKEDTVTRRELQNLIGAVNQLNVLTKELTKRHNLLRNEVQSRSEAFERRISDHALETEDGLNKTMIVINNAIDFVQDNYVLKETLSAKPYNPKVCECNQNMDAILSFISEFQHLNDSIQTLVNDNQKYNFILQIAKALTAIPKDEKLSQLNFQKVYQMYNETTSQVSKCQQNVSYLKEHMLAVKKNTKEFETRLQGIESKVTKALIPYYISFKKGGSLSNGDPDLQLKVLNTRFKALEAKSIHLSVSFSSLNKTVHELSMACCNASTSTYGQNASIPMWTKGSLTDSQRSLKSLTELVESIVEMKTQAVLSNLTWNVDRLVSDSLANIVKPQKQIKLQKKPNTLKKTVNMTTILIGRTQRNTDSITHPAAQEYSSCSSFPCQNGGTCISGRSSFICACRHPFMGDTCTVKIVEENALAPDFSKGSYRYAPMVAFFVSHTHGMTAPGPILFNDLSVNYGASYNPRTGKFRIPYLGVYIFKYTIESFSAHISGFFVVDGVDKLRFESENTDSEIHCDRVLTGDALFELNYGQEVWLRLVKGTIPIKYPPVTTFSGYLLYRT", "length": 1210 }, "evidence": [ { "id": "A0A3Q1M2H1", "url": "https://omabrowser.org/oma/group/A0A3Q1M2H1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q13201-1", "protein_name": "Multimerin-1", "gene_name": "MMRN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKGARLFVLLSSLWSGGIGLNNSKHSWTIPEDGNSQKTMPSASVPPNKIQSLQILPTTRVMSAEIATTPEARTSEDSLLKSTLPPSETSAPAEGVRNQTLTSTEKAEGVVKLQNLTLPTNASIKFNPGAESVVLSNSTLKFLQSFARKSNEQATSLNTVGGTGGIGGVGGTGGVGNRAPRETYLSRGDSSSSQRTDYQKSNFETTRGKNWCAYVHTRLSPTVILDNQVTYVPGGKGPCGWTGGSCPQRSQKISNPVYRMQHKIVTSLDWRCCPGYSGPKCQLRAQEQQSLIHTNQAESHTAVGRGVAEQQQQQGCGDPEVMQKMTDQVNYQAMKLTLLQKKIDNISLTVNDVRNTYSSLEGKVSEDKSREFQSLLKGLKSKSINVLIRDIVREQFKIFQNDMQETVAQLFKTVSSLSEDLESTRQIIQKVNESVVSIAAQQKFVLVQENRPTLTDIVELRNHIVNVRQEMTLTCEKPIKELEVKQTHLEGALEQEHSRSILYYESLNKTLSKLKEVHEQLLSTEQVSDQKNAPAAESVSNNVTEYMSTLHENIKKQSLMMLQMFEDLHIQESKINNLTVSLEMEKESLRGECEDMLSKCRNDFKFQLKDTEENLHVLNQTLAEVLFPMDNKMDKMSEQLNDLTYDMEILQPLLEQGASLRQTMTYEQPKEAIVIRKKIENLTSAVNSLNFIIKELTKRHNLLRNEVQGRDDALERRINEYALEMEDGLNKTMTIINNAIDFIQDNYALKETLSTIKDNSEIHHKCTSDMETILTFIPQFHRLNDSIQTLVNDNQRYNFVLQVAKTLAGIPRDEKLNQSNFQKMYQMFNETTSQVRKYQQNMSHLEEKLLLTTKISKNFETRLQDIESKVTQTLIPYYISVKKGSVVTNERDQALQLQVLNSRFKALEAKSIHLSINFFSLNKTLHEVLTMCHNASTSVSELNATIPKWIKHSLPDIQLLQKGLTEFVEPIIQIKTQAALSNLTCCIDRSLPGSLANVVKSQKQVKSLPKKINALKKPTVNLTTVLIGRTQRNTDNIIYPEEYSSCSRHPCQNGGTCINGRTSFTCACRHPFTGDNCTIKLVEENALAPDFSKGSYRYAPMVAFFASHTYGMTIPGPILFNNLDVNYGASYTPRTGKFRIPYLGVYVFKYTIESFSAHISGFLVVDGIDKLAFESENINSEIHCDRVLTGDALLELNYGQEVWLRLAKGTIPAKFPPVTTFSGYLLYRT", "length": 1228 }, "evidence": [ { "id": "A0A3Q1M2H1", "url": "https://omabrowser.org/oma/group/A0A3Q1M2H1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of cell migration involved in sprouting angiogenesis", "id": "GO:0090051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090051", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2H1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H1" } ], "pmid": "" }, { "name": "cell adhesion mediated by integrin", "id": "GO:0033627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033627", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2H1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H1" } ], "pmid": "" }, { "name": "negative regulation of wound healing", "id": "GO:0061045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061045", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2H1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H1" } ], "pmid": "" }, { "name": "negative regulation of vascular endothelial growth factor receptor signaling pathway", "id": "GO:0030948", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030948", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2H1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H1" } ], "pmid": "" }, { "name": "positive regulation of platelet aggregation", "id": "GO:1901731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901731", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2H1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2H1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H1" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2H1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H1" } ], "pmid": "" }, { "name": "platelet alpha granule", "id": "GO:0031091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031091", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2H1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2H1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1007, "end_pos": 1009, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1064, "end_pos": 1066, "annotation": "n_glycosylation_sequon" }, { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 165, "end_pos": 167, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" }, { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 495, "end_pos": 497, "annotation": "n_glycosylation_sequon" }, { "start_pos": 529, "end_pos": 531, "annotation": "n_glycosylation_sequon" }, { "start_pos": 564, "end_pos": 566, "annotation": "n_glycosylation_sequon" }, { "start_pos": 606, "end_pos": 608, "annotation": "n_glycosylation_sequon" }, { "start_pos": 717, "end_pos": 719, "annotation": "n_glycosylation_sequon" }, { "start_pos": 771, "end_pos": 773, "annotation": "n_glycosylation_sequon" }, { "start_pos": 779, "end_pos": 781, "annotation": "n_glycosylation_sequon" }, { "start_pos": 816, "end_pos": 818, "annotation": "n_glycosylation_sequon" }, { "start_pos": 828, "end_pos": 830, "annotation": "n_glycosylation_sequon" }, { "start_pos": 876, "end_pos": 878, "annotation": "n_glycosylation_sequon" }, { "start_pos": 904, "end_pos": 906, "annotation": "n_glycosylation_sequon" }, { "start_pos": 909, "end_pos": 911, "annotation": "n_glycosylation_sequon" }, { "start_pos": 930, "end_pos": 932, "annotation": "n_glycosylation_sequon" }, { "start_pos": 969, "end_pos": 971, "annotation": "n_glycosylation_sequon" }, { "start_pos": 975, "end_pos": 977, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M2H1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1217, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M2H1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M2H1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M2H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H1" }, { "id": "PS50871", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50871" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C1q", "eco_id": "ECO_0000259", "start_pos": 1085, "end_pos": 1217, "start_aa": "Arg", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1M2H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H1" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 1030, "end_pos": 1066, "start_aa": "Glu", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1M2H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H1" }, { "id": "PS51041", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51041" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EMI", "eco_id": "ECO_0000259", "start_pos": 196, "end_pos": 271, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1007, "end_pos": 1009 }, { "start_pos": 1064, "end_pos": 1066 }, { "start_pos": 137, "end_pos": 139 }, { "start_pos": 165, "end_pos": 167 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 38, "end_pos": 40 }, { "start_pos": 419, "end_pos": 421 }, { "start_pos": 495, "end_pos": 497 }, { "start_pos": 529, "end_pos": 531 }, { 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"keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-1614558", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614558", "resource": "Reactome", "description": "Degradation of cysteine and homocysteine" }, { "id": "R-BTA-1614603", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614603", "resource": "Reactome", "description": "Cysteine formation from homocysteine" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2L1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2L1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2L1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2L1" } ], "pmid": "" }, { "name": "cystathionine gamma-lyase activity", "id": "GO:0004123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004123", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2L1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2L1" } ], "pmid": "" }, { "name": "homocysteine desulfhydrase activity", "id": "GO:0047982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047982", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2L1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2L1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "transsulfuration", "id": "GO:0019346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019346", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2L1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2L1" } ], "pmid": "" }, { "name": "cysteine biosynthetic process via cystathionine", "id": "GO:0019343", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019343", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2L1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2L1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 401, "end_pos": 403, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14005", "name": "", "equation": "L,L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M2L1-1", "E1BNH2-1", "Q58DW2-1" ], "evidence": [ { "id": "14005", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14005" } ] }, { "id": "14501", "name": "", "equation": "L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M2L1-1", "E1BNH2-1" ], "evidence": [ { "id": "14501", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14501" } ] }, { "id": "24923", "name": "", "equation": "L-homoserine = 2-oxobutanoate + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M2L1-1", "E1BNH2-1" ], "evidence": [ { "id": "24923", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24923" } ] }, { "id": "24931", "name": "", "equation": "L-cysteine + H2O = hydrogen sulfide + pyruvate + NH4(+) + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M2L1-1", "E1BNH2-1" ], "evidence": [ { "id": "24931", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24931" } ] }, { "id": "31151", "name": "", "equation": "L-selenocystathionine + H2O = L-selenocysteine + 2-oxobutanoate + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M2L1-1", "E1BNH2-1" ], "evidence": [ { "id": "31151", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/31151" } ] }, { "id": "R-BTA-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1614594" ], "enzyme_list": [ "A0A3Q1M2L1-1" ], "evidence": [ { "id": "R-BTA-1614567", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614567" } ] }, { "id": "R-BTA-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-1614518" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M2L1-1" ], "evidence": [ { "id": "R-BTA-1614583", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614583" } ] }, { "id": "R-BTA-1614591", "name": "Excess cysteine yields lanthionine and H2S", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1614532", "R-ALL-1614582" ], "enzyme_list": [ "A0A3Q1M2L1-1" ], "evidence": [ { "id": "R-BTA-1614591", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614591" } ] }, { "id": "R-BTA-1614614", "name": "Cysteine is degraded to pyruvate and H2S", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M2L1-1" ], "evidence": [ { "id": "R-BTA-1614614", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614614" } ] }, { "id": "R-BTA-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-936714" ], "enzyme_list": [ "A0A3Q1M2L1-1" ], "evidence": [ { "id": "R-BTA-1614631", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1614631" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1614518", "participant_name": "L-Cystathionine [cytosol]", "crossref": [ { "id": "58161", "database": "ChEBI", "url": "" }, { "id": "ZINC000001532680", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-1614532", "participant_name": "H2S [cytosol]", "crossref": [ { "id": "29919", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1614582", "participant_name": "L-Lanthionine [cytosol]", "crossref": [ { "id": "178193", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1614594", "participant_name": "HLAN [cytosol]", "crossref": [ { "id": "178194", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-936714", "participant_name": "2OBUTA [cytosol]", "crossref": [ { "id": "3593277", "database": "PubChem Compound", "url": "" }, { "id": "2-OXOBUTANOATE", "database": "AraCyc", "url": "" }, { "id": "16763", "database": "ChEBI", "url": "" }, { "id": "C00109", "database": "KEGG Gene", "url": "" }, { "id": "ZINC000001532540", "database": "ZINC", "url": "" }, { "id": "600-18-0", "database": "CAS", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M2L1", "gene_name": "", "activity": [ { "ec_number": "4.4.1.1", "activity": "L,L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4(+).", "evidence": [ { "id": "A0A3Q1M2L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2L1" } ] }, { "ec_number": "4.4.1.2", "activity": "L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+).", "evidence": [ { "id": "A0A3Q1M2L1", "database": "UniProtKB", "url": 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], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.4.1.1", "ec_name": "L,L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4(+).", "evidence": [ { "id": "4.4.1.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.1" }, { "id": "4.4.1.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.4.1.1" } ] }, { "ec_number": "4.4.1.2", "ec_name": "L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+).", "evidence": [ { "id": "4.4.1.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.2" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 401, "end_pos": 403 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { 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"graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M2M3-1", "uniprot_ac": "A0A3Q1M2M3", "uniprot_id": "A0A3Q1M2M3_BOVIN", "mass": { "chemical_mass": 88973.0, "monoisotopic_mass": 88973.0 }, "refseq": { "ac": "XP_005201473", "name": "zinc finger protein 148 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201473" }, "gene_names": [ { "name": "ZNF148", "type": "recommended", "evidence": [ { "id": "A0A3Q1M2M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3" } ] }, { "name": "ZNF148", "type": "synonym", "evidence": [ { "id": "XP_005201473", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201473" } ] } ], "protein_names": [ { "name": "Zinc finger protein 148", "type": "recommended", "evidence": [ { "id": "A0A3Q1M2M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 148 isoform X1", "type": "synonym", 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Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2M3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3#function" }, { "database": "UniProtKB", "id": "ARBA00060069", "url": "https://www.uniprot.org/uniprotkb/ARBA00060069#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2M3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF148", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3", "locus": { "chromosome": "1", "start_pos": 69685147, "end_pos": 69776257, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000050482", "url": "https://www.ensembl.org/id/ENSBTAG00000050482" } ] } } ], "crossref": [ { "id": "A0A3Q1M2M3", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M2M3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050482", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050482", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "613265", "url": "https://www.ncbi.nlm.nih.gov/gene/613265", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QPMNTEI", "url": "https://omabrowser.org/oma/group/QPMNTEI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2M3", "url": "https://www.orthodb.org/?gene=A0A3Q1M2M3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF155", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF155", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404:SF53", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404:SF53", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005201473", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201473", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2M3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2M3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS47", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS47-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNIDDKLEGLFLKCGGIDEMQSSRAMVVMGGVSGQSTVSGELQESVLQDRSMPHQEILAADEVLQESEMRQQDMISHDELMVHEETVKNDEEQMETHERLPQGLQYALNVPISVKQEITFTDVSEQLMRDKKQIREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTPKSHVCEHCNAAFRTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKYHMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRMCHENHDKKLNRCAIKGGLLTSEEDSGFSTSPKDNSLPKKKRQKTEKKSSGMDKESSLDKSDLKKDKNDYLPLYSSSTKVKDEYMVAEYAVEMPHSSVGGSHLEDASGEIHPPKLVLKKINSKRSLKQPLEQNQTISPLSTYEESKVSKYAFELVDKQALLDSEGNADIDQVDNLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAASNNSREYALNVGTIASQPSVTQAAVASVIDESTTASILDSQALNVEIKSNHDKNVIPDEVLQTLLDHYSHKANGQHEISFSVADTEVTSSISINSSEVPEVTQSENVGSSSQASSSDKANMLQEYSKFLQQALDRTSQNDAYLNSPSLNFVTDNQTLPNQPAFSSIDKQVYAAMPINSFRSGMNSPLRTTPDKSHFGLIVGDSQHSFPFSGDETNHASATSTQDFLDQVTSQKKAEAQPVHQAYQMSSFEQPFRAPYHGSRAGIATQFSTANGQVNLRGPGTSAEFPEFPLVNVNDNRAGMTSSPDATTGQTFG", "length": 794, "header": "tr|A0A3Q1M2M3-1|A0A3Q1M2M3_BOVIN Isoform 1 of Zinc finger protein 148 OS=Bos taurus OX=9913 GN=ZNF148 PE=3 SV=1 CANONICAL=A0A3Q1M2M3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M2M3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3/entry", "sequence": { "sequence": "MNIDDKLEGLFLKCGGIDEMQSSRAMVVMGGVSGQSTVSGELQESVLQDRSMPHQEILAADEVLQESEMRQQDMISHDELMVHEETVKNDEEQMETHERLPQGLQYALNVPISVKQEITFTDVSEQLMRDKKQIREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTPKSHVCEHCNAAFRTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKYHMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRMCHENHDKKLNRCAIKGGLLTSEEDSGFSTSPKDNSLPKKKRQKTEKKSSGMDKESSLDKSDLKKDKNDYLPLYSSSTKVKDEYMVAEYAVEMPHSSVGGSHLEDASGEIHPPKLVLKKINSKRSLKQPLEQNQTISPLSTYEESKVSKYAFELVDKQALLDSEGNADIDQVDNLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAASNNSREYALNVGTIASQPSVTQAAVASVIDESTTASILDSQALNVEIKSNHDKNVIPDEVLQTLLDHYSHKANGQHEISFSVADTEVTSSISINSSEVPEVTQSENVGSSSQASSSDKANMLQEYSKFLQQALDRTSQNDAYLNSPSLNFVTDNQTLPNQPAFSSIDKQVYAAMPINSFRSGMNSPLRTTPDKSHFGLIVGDSQHSFPFSGDETNHASATSTQDFLDQVTSQKKAEAQPVHQAYQMSSFEQPFRAPYHGSRAGIATQFSTANGQVNLRGPGTSAEFPEFPLVNVNDNRAGMTSSPDATTGQTFG", "length": 794, "header": "tr|A0A3Q1M2M3-1|A0A3Q1M2M3_BOVIN Isoform 1 of Zinc finger protein 148 OS=Bos taurus OX=9913 GN=ZNF148 PE=3 SV=1 CANONICAL=A0A3Q1M2M3-1" }, "locus": { "chromosome": "1", "start_pos": 69766359, "end_pos": 69686151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070820.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070820.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067678.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067678.1" } ] } }, { "isoform_ac": "A0AAA9TS47-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS47/entry", "sequence": { "sequence": "MKGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGDETNHASATSTQDFLDQVTSQKKAEAQPVHQAYQMSSFEQPFRAPYHGSRAGIATQFSTANGQVNLRGPGTSAEFPEFPLVNVNDNRAGMTSSPDATTGQTFG", "length": 144, "header": "tr|A0AAA9TS47-1|A0A3Q1M2M3_BOVIN Computationally mapped isoform of Zinc finger protein 148 OS=Bos taurus OX=9913 GN=ZNF148 PE=3 SV=2 CANONICAL=A0A3Q1M2M3-1" }, "locus": { "chromosome": "1", "start_pos": 69776207, "end_pos": 69686151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108972.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108972.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101420.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101420.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z7H0-1", "protein_name": "Zinc finger protein 148", "gene_name": "ZNF148", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MYTCVQFPEFGKQRGTALEQSPCTGLILQLICSADVLLHLRMNIEDKLGGLFLKCGGIDQMQSSRAMVGMGAVSDQSGVSGERQEAVLQDRTMAHQEILAPDEVLQESELRQQEMISHDELMVHEETVKNDDDMDTQDRLPQGLQYAVNVPISVKQEITFTDASEQQKRDKKQIREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTHKSHVCEHCNAAFRTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKYHMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRMCHENRDKKPNRSATKVGFLPSEEDSGFSTPMKDSSLPKKKRQKTEKTKSGDKDGTDKSEQKKDKNDYLPLYSASTKVKDEYMVAEYAVEMPHSSVSGSHLEEANSGEIHPPKLVLKKVNSKRSLKQPLEQSQSISPLSTYEDSKVSKYTFDLVDKQSLLDSEGNADIDQVDTLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAASNNSREYALNVSTIASQPSVTQAAVASVIDETATASILDTQALNVEIKGSHDKNVIPDEVLQTLLDHYSHKANGQHEISFSVADTEVTSSISINSSEVSEVTQSETVGTSSQASSSDKASMLQEYSKFLQQALDRTSQNDAYLNNPSLNFVTDNQTLTTQPAFPSIEKQVYTSIPVNSFRSGMNSPLRTTPDKSHFGLMVGDSQHPFPFSGDEANHSSSSSTQDFLEQVTSQKKAEAQPVHQAYQISSFEQPFRAQYHGARAGISSQFSTANGQVNLRGPGTSADFPEFPLVNVNDSRAGMTSSPDATTGQTFG", "length": 833 }, "evidence": [ { "id": "A0A3Q1M2M3", "url": "https://omabrowser.org/oma/group/A0A3Q1M2M3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0MS83-1", "protein_name": "Zinc finger protein 148", "gene_name": "znf148", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": 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{ "uniprot_canonical_ac": "Q61624-1", "protein_name": "Zinc finger protein 148", "gene_name": "Znf148", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNIDDKLEGLFLKCGGIDEMQSSRAMVVMGGVSGQSAVSGELQESVLQDRSLPHQEILAADEVLQESEMRQQDMISHDELMVHEETVKNDEEQMDTHERLPQGLQYALNVPISVKQEITFTDVSEQLMRDKKQVREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTPKSHVCEHCNAAFRTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKYHMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRMCHENHDKKLNRCAIKGGLLTSEEDSGFSTSPKDNSLPKKKRQKTEKKSSGMDKESVLDKSDLKKDKNDYLPLYSSSTKVKDEYMVAEYAVEMPHSSVGGSHLEDASGEIHPPKLVLKKINSKRSLKQPLEQSQTISPLSSYEDSKVSKYAFELVDKQALLDSEGSADIDQVDNLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAASNNSREYALNVGTIASQPSVTQAAVASVIDESTTASILDSQALNVEIKSNHDKNVIPDEVLQTLLDHYSHKPNGQHEISFSVADTEVTSSISINSSDVPEVTQSENVGSSSQASSSDKANMLQEYSKFLQQALDRTSQNDAYLNSPSLNFVTDNQTLPNPPAFSSIDKQVYAAMPINSFRSGMNSPLRTTPDKSHFGLIVGDSQHPFPFSGDETNHASATSTADFLDQVTSQKKAEAQPVHQAYQMSSFEQPFRAPYHGSRAGIATQFSTANGQVNLRGPGTSAEFSEFPLVNVNDNRAGMTSSPDATTGQTFG", "length": 794 }, "evidence": [ { "id": "A0A3Q1M2M3", "url": "https://omabrowser.org/oma/group/A0A3Q1M2M3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q62806-1", "protein_name": "Zinc finger protein 148", "gene_name": "Znf148", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"Q9UQR1-1", "protein_name": "Zinc finger protein 148", "gene_name": "ZNF148", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNIDDKLEGLFLKCGGIDEMQSSRTMVVMGGVSGQSTVSGELQDSVLQDRSMPHQEILAADEVLQESEMRQQDMISHDELMVHEETVKNDEEQMETHERLPQGLQYALNVPISVKQEITFTDVSEQLMRDKKQIREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTPKSHVCEHCNAAFRTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKYHMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRMCHENHDKKLNRCAIKGGLLTSEEDSGFSTSPKDNSLPKKKRQKTEKKSSGMDKESALDKSDLKKDKNDYLPLYSSSTKVKDEYMVAEYAVEMPHSSVGGSHLEDASGEIHPPKLVLKKINSKRSLKQPLEQNQTISPLSTYEESKVSKYAFELVDKQALLDSEGNADIDQVDNLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAASNNSREYALNVGTIASQPSVTQAAVASVIDESTTASILESQALNVEIKSNHDKNVIPDEVLQTLLDHYSHKANGQHEISFSVADTEVTSSISINSSEVPEVTPSENVGSSSQASSSDKANMLQEYSKFLQQALDRTSQNDAYLNSPSLNFVTDNQTLPNQPAFSSIDKQVYATMPINSFRSGMNSPLRTTPDKSHFGLIVGDSQHSFPFSGDETNHASATSTQDFLDQVTSQKKAEAQPVHQAYQMSSFEQPFRAPYHGSRAGIATQFSTANGQVNLRGPGTSAEFSEFPLVNVNDNRAGMTSSPDATTGQTFG", "length": 794 }, "evidence": [ { "id": "A0A3Q1M2M3", "url": "https://omabrowser.org/oma/group/A0A3Q1M2M3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2M3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2M3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2M3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2M3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2M3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2M3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2M3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2M3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2M3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2M3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 408, "end_pos": 410, "annotation": "n_glycosylation_sequon" }, { "start_pos": 482, "end_pos": 484, "annotation": "n_glycosylation_sequon" }, { "start_pos": 574, "end_pos": 576, "annotation": "n_glycosylation_sequon" }, { "start_pos": 634, "end_pos": 636, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M2M3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 794, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M2M3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M2M3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M2M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2M3" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 171, "end_pos": 198, "start_aa": "His", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 408, "end_pos": 410 }, { "start_pos": 482, "end_pos": 484 }, { "start_pos": 574, "end_pos": 576 }, { "start_pos": 634, "end_pos": 636 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"A0A3Q1M2N5_BOVIN", "mass": { "chemical_mass": 35248.0, "monoisotopic_mass": 35248.0 }, "refseq": { "ac": "NP_001377685", "name": "olfactory receptor family 9 subfamily A member 16", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377685" }, "gene_names": [ { "name": "OR9A16", "type": "recommended", "evidence": [ { "id": "A0A3Q1M2N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2N5" } ] }, { "name": "OR9A16", "type": "synonym", "evidence": [ { "id": "NP_001377685", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377685" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0A3Q1M2N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2N5/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 9 subfamily A member 16", "type": "synonym", "evidence": [ { "id": "NP_001377685", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377685" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377685" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2N5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2N5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M2N5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2N5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR9A16", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2N5", "locus": { "chromosome": "4", "start_pos": 106385928, "end_pos": 106384987, 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"https://www.uniprot.org/uniprotkb/A0A3Q1MNQ1" } ] }, { "ec_number": "2.7.7.19", "activity": "RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate.", "evidence": [ { "id": "A0A3Q1MNQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNQ1" } ] }, { "ec_number": "2.7.7.52", "activity": "", "evidence": [ { "id": "A0A3Q1MNQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNQ1" } ] }, { "ec_number": "2.7.7.19", "activity": "", "evidence": [ { "id": "A0A3Q1MNQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNQ1" } ] } ] }, { "uniprot_ac": "A0AAA9SIZ0", "gene_name": "TUT7", "activity": [ { "ec_number": "2.7.7.52", "activity": "RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate.", "evidence": [ { "id": "A0AAA9SIZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIZ0" } ] }, { "ec_number": "2.7.7.52", "activity": "", "evidence": [ { "id": "A0AAA9SIZ0", "database": 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"name": "MLX", "type": "synonym", "evidence": [ { "id": "XP_005220746", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220746" } ] } ], "protein_names": [ { "name": "Max-like protein X", "type": "recommended", "evidence": [ { "id": "A0A3Q1M308", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M308/entry#names_and_taxonomy" } ] }, { "name": "Max-like bHLHZip protein", "type": "synonym", "evidence": [ { "id": "A0A3Q1M308", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M308/entry#names_and_taxonomy" } ] }, { "name": "Protein BigMax", "type": "synonym", "evidence": [ { "id": "A0A3Q1M308", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M308/entry#names_and_taxonomy" } ] }, { "name": "Transcription factor-like protein 4", "type": "synonym", "evidence": [ { "id": "A0A3Q1M308", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M308/entry#names_and_taxonomy" } ] }, { 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heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M308", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M308" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M308", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M308" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M308", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M308" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", 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{ "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M326-1", "uniprot_ac": "A0A3Q1M326", "uniprot_id": "A0A3Q1M326_BOVIN", "mass": { "chemical_mass": 67754.0, "monoisotopic_mass": 67754.0 }, "refseq": {}, "gene_names": [ { "name": "SYNCRIP", "type": "recommended", "evidence": [ { "id": "A0A3Q1M326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ] } ], "protein_names": [ { "name": "Synaptotagmin binding cytoplasmic RNA interacting protein", "type": "synonym", "evidence": [ { "id": "A0A3Q1M326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYNCRIP", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326", "locus": { "chromosome": "9", "start_pos": 63845074, "end_pos": 63819909, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006672", "url": "https://www.ensembl.org/id/ENSBTAG00000006672" } ] } } ], "crossref": [ { "id": "A0A3Q1M326", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M326", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006672", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006672", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12483", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12483", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12489", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12489", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12495", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12495", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21066", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21066", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511763", "url": "https://www.ncbi.nlm.nih.gov/gene/511763", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006535", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006535", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034544", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034544", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M326", "url": "https://www.orthodb.org/?gene=A0A3Q1M326", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MCT8", "url": "https://www.orthodb.org/?gene=F1MCT8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21245", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21245", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18360", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18360", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M326-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0G8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0G8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NNB0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NNB0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P5C8", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5C8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P5C8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5C8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCT8", "url": "https://www.uniprot.org/uniprotkb/F1MCT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCT8-1", "url": "https://www.uniprot.org/uniprotkb/F1MCT8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKVNNWGNNRYLISEGFRKLKETQRSYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQNWGSQPIAQQPLQGGDHSGNYGYKSENQEFYQDTFGQQWK", "length": 606, "header": "tr|A0A3Q1M326-1|A0A3Q1M326_BOVIN Isoform 1 of Synaptotagmin binding cytoplasmic RNA interacting protein OS=Bos taurus OX=9913 GN=SYNCRIP PE=1 SV=1 CANONICAL=A0A3Q1M326-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M326-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326/entry", "sequence": { "sequence": "MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKVNNWGNNRYLISEGFRKLKETQRSYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQNWGSQPIAQQPLQGGDHSGNYGYKSENQEFYQDTFGQQWK", "length": 606, "header": "tr|A0A3Q1M326-1|A0A3Q1M326_BOVIN Isoform 1 of Synaptotagmin binding cytoplasmic RNA interacting protein OS=Bos taurus OX=9913 GN=SYNCRIP PE=1 SV=1 CANONICAL=A0A3Q1M326-1" }, "locus": { "chromosome": "9", "start_pos": 63842193, "end_pos": 63821395, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086528.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086528.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067867.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067867.1" } ] } }, { "isoform_ac": "A0AAA9SYW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW9/entry", "sequence": { "sequence": "MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGQGKGVEAGPDLLQ", "length": 465, "header": "tr|A0AAA9SYW9-1|A0A3Q1M326_BOVIN Computationally mapped isoform of Synaptotagmin binding cytoplasmic RNA interacting protein OS=Bos taurus OX=9913 GN=SYNCRIP PE=1 SV=1 CANONICAL=A0A3Q1M326-1" }, "locus": { "chromosome": "9", "start_pos": 63844070, "end_pos": 63821395, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123564.2", "url": "https://www.ensembl.org/id/ENSBTAT00000123564.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089474.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089474.1" } ] } }, { "isoform_ac": "A0AAA9T0G8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0G8/entry", "sequence": { "sequence": "MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKV", "length": 337, "header": "tr|A0AAA9T0G8-1|A0A3Q1M326_BOVIN Computationally mapped isoform of Synaptotagmin binding cytoplasmic RNA interacting protein OS=Bos taurus OX=9913 GN=SYNCRIP PE=1 SV=1 CANONICAL=A0A3Q1M326-1" }, "locus": { "chromosome": "9", "start_pos": 63841607, "end_pos": 63821395, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131868.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131868.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089140.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089140.1" } ] } }, { "isoform_ac": "A0AAA9TRU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRU9/entry", "sequence": { "sequence": "MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGQGKGVEAGPDLLQ", "length": 524, "header": "tr|A0AAA9TRU9-1|A0A3Q1M326_BOVIN Computationally mapped isoform of Synaptotagmin binding cytoplasmic RNA interacting protein OS=Bos taurus OX=9913 GN=SYNCRIP PE=1 SV=1 CANONICAL=A0A3Q1M326-1" }, "locus": { "chromosome": "9", "start_pos": 63844070, "end_pos": 63821395, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120946.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120946.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101314.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101314.1" } ] } }, { "isoform_ac": "A0ABI0NNB0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NNB0/entry", "sequence": { "sequence": "MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGQGKGVEAGPDLLQ", "length": 562, "header": "tr|A0ABI0NNB0-1|A0ABI0NNB0_BOVIN Computationally mapped isoform of Synaptotagmin binding cytoplasmic RNA interacting protein OS=Bos taurus OX=9913 GN=SYNCRIP PE=1 SV=1 CANONICAL=A0A3Q1M326-1" }, "locus": { "chromosome": "9", "start_pos": 63844070, "end_pos": 63821395, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143902.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143902.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107127.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107127.1" } ] } }, { "isoform_ac": "A0ABI0P5C8-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5C8/entry", "sequence": { "sequence": "MKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQNWGSQPIAQQPLQGGDHSGNYGYKSENQEFYQDTFGQQWK", "length": 525, "header": "tr|A0ABI0P5C8-1|A0ABI0P5C8_BOVIN Computationally mapped isoform of Synaptotagmin binding cytoplasmic RNA interacting protein OS=Bos taurus OX=9913 GN=SYNCRIP PE=1 SV=1 CANONICAL=A0A3Q1M326-1" }, "locus": { "chromosome": "9", "start_pos": 63842193, "end_pos": 63822502, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145442.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145442.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107140.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107140.1" } ] } }, { "isoform_ac": "F1MCT8-1", "url": "https://www.uniprot.org/uniprotkb/F1MCT8/entry", "sequence": { "sequence": "MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGGKGVEAGPDLLQ", "length": 561, "header": "tr|F1MCT8-1|A0A3Q1M326_BOVIN Computationally mapped isoform of Synaptotagmin binding cytoplasmic RNA interacting protein OS=Bos taurus OX=9913 GN=SYNCRIP PE=1 SV=4 CANONICAL=A0A3Q1M326-1" }, "locus": { "chromosome": "9", "start_pos": 63844070, "end_pos": 63821395, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008774.8", "url": "https://www.ensembl.org/id/ENSBTAT00000008774.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008774.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008774.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "CRD-mediated mRNA stabilization", "id": "GO:0070934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070934", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" }, { "name": "positive regulation of cytoplasmic translation", "id": "GO:2000767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000767", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" }, { "name": "negative regulation of translation", "id": "GO:0017148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" }, { "name": "cellular response to type II interferon", "id": "GO:0071346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071346", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" }, { "name": "negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "id": "GO:1900152", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900152", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" }, { "name": "mRNA 5'-UTR binding", "id": "GO:0048027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048027", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" }, { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" }, { "name": "GAIT complex", "id": "GO:0097452", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097452", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" }, { "name": "CRD-mediated mRNA stability complex", "id": "GO:0070937", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070937", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M326", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M326-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 606, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M326-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M326" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M326" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 162, "end_pos": 241, "start_aa": "Thr", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 90, "end_pos": 92 }, { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M331-1", "uniprot_ac": "A0A3Q1M331", "uniprot_id": "A0A3Q1M331_BOVIN", "mass": { "chemical_mass": 92727.0, "monoisotopic_mass": 92727.0 }, "refseq": {}, "gene_names": [ { "name": "ATXN1", "type": "recommended", "evidence": [ { "id": "A0A3Q1M331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ] } ], "protein_names": [ { "name": "Ataxin 1", "type": "synonym", "evidence": [ { "id": "A0A3Q1M331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATXN1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331", "locus": { "chromosome": "23", "start_pos": 40835517, "end_pos": 40688296, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019675", "url": "https://www.ensembl.org/id/ENSBTAG00000019675" } ] } } ], "crossref": [ { "id": "A0A3Q1M331", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M331", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019675", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019675", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616399", "url": "https://www.ncbi.nlm.nih.gov/gene/616399", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020997", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020997", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HHQGGTH", "url": "https://omabrowser.org/oma/group/HHQGGTH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M331", "url": "https://www.orthodb.org/?gene=A0A3Q1M331", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BDF7", "url": "https://www.orthodb.org/?gene=E1BDF7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13392", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13392", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13392:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13392:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08517", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08517", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12547", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12547", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M331-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDF7", "url": "https://www.uniprot.org/uniprotkb/E1BDF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BDF7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDF7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSNQERSNECLPPKKREIPATSRPSSEDKAVPSDNHRAENAAWLPGARGHVGGRLGPAGPPAELAAELGLQQGIGLHKALSTGLDYSPPSAPRSVPAVTSTTTMPAAYPPPPPSGAPVSPVQYAHLPHTLQFIGSSQYSGPYAGFIPSQLISPTASPVTSAVASAVGAATPAQRSQLEAYSSLLADMGGLSRASGHKAEPPPPPPPPQHLGRTAGLLPPGSPPHPQQSQYVRISSSPQNAARPASPPTLPVHLHTHPTMIPHTLTLGPSPQVVVQYTDSSSHFVTREATKKAESSRLQQAMQAKEMLNGEVEKGRRYGAPPAADLGLVKAASKAVPHPYESRHVVVHPGPADYSVRDASGVRASVMVLPNSSTPAADLEGQQVTHRENSPSALNDKSGLHLGKPGHRSYALSPQQVLGPEGVKAVATLSPHTVIQTTHSASEALPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGGLPPHLVIPGTQPLLIPVGSADLEGSGAASAIVTSSPQFAAVPHTFVTTALPKSENFGPEALVTQAAYPAMVQAQIHLPVAQSVASPAAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISTDLKIDSSTVERIADSHSPGVAVIQFAVGDHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGISQGSAQMLSENGELKFPEKIGLPATPLLTKIEPSKPAATRKRRWSAPETRKLEKSEDEPPLTLPKPSLISQEVKICIEGRSNVGFCYNLVIRVTAGVGQAIGAYAFSRRVSRQVGCQALQSFSRSKMLKVSKWFQGMNVNYELVCDNE", "length": 880, "header": "tr|A0A3Q1M331-1|A0A3Q1M331_BOVIN Isoform 1 of Ataxin 1 OS=Bos taurus OX=9913 GN=ATXN1 PE=3 SV=3 CANONICAL=A0A3Q1M331-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M331-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331/entry", "sequence": { "sequence": "MKSNQERSNECLPPKKREIPATSRPSSEDKAVPSDNHRAENAAWLPGARGHVGGRLGPAGPPAELAAELGLQQGIGLHKALSTGLDYSPPSAPRSVPAVTSTTTMPAAYPPPPPSGAPVSPVQYAHLPHTLQFIGSSQYSGPYAGFIPSQLISPTASPVTSAVASAVGAATPAQRSQLEAYSSLLADMGGLSRASGHKAEPPPPPPPPQHLGRTAGLLPPGSPPHPQQSQYVRISSSPQNAARPASPPTLPVHLHTHPTMIPHTLTLGPSPQVVVQYTDSSSHFVTREATKKAESSRLQQAMQAKEMLNGEVEKGRRYGAPPAADLGLVKAASKAVPHPYESRHVVVHPGPADYSVRDASGVRASVMVLPNSSTPAADLEGQQVTHRENSPSALNDKSGLHLGKPGHRSYALSPQQVLGPEGVKAVATLSPHTVIQTTHSASEALPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGGLPPHLVIPGTQPLLIPVGSADLEGSGAASAIVTSSPQFAAVPHTFVTTALPKSENFGPEALVTQAAYPAMVQAQIHLPVAQSVASPAAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISTDLKIDSSTVERIADSHSPGVAVIQFAVGDHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGISQGSAQMLSENGELKFPEKIGLPATPLLTKIEPSKPAATRKRRWSAPETRKLEKSEDEPPLTLPKPSLISQEVKICIEGRSNVGFCYNLVIRVTAGVGQAIGAYAFSRRVSRQVGCQALQSFSRSKMLKVSKWFQGMNVNYELVCDNE", "length": 880, "header": "tr|A0A3Q1M331-1|A0A3Q1M331_BOVIN Isoform 1 of Ataxin 1 OS=Bos taurus OX=9913 GN=ATXN1 PE=3 SV=3 CANONICAL=A0A3Q1M331-1" }, "locus": { "chromosome": "23", "start_pos": 40829583, "end_pos": 40810871, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069187.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069187.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064481.3", "url": "https://www.ensembl.org/id/ENSBTAP00000064481.3" } ] } }, { "isoform_ac": "E1BDF7-1", "url": "https://www.uniprot.org/uniprotkb/E1BDF7/entry", "sequence": { "sequence": "MKSNQERSNECLPPKKREIPATSRPSSEDKAVPSDNHRAENAAWLPGARGHVGGRLGPAGPPAELAAELGLQQGIGLHKALSTGLDYSPPSAPRSVPAVTSTTTMPAAYPPPPPSGAPVSPVQYAHLPHTLQFIGSSQYSGPYAGFIPSQLISPTASPVTSAVASAVGAATPAQRSQLEAYSSLLADMGGLSRASGHKAEPPPPPPPPQHLGRTAGLLPPGSPPHPQQSQYVRISSSPQNAARPASPPTLPVHLHTHPTMIPHTLTLGPSPQVVVQYTDSSSHFVTREATKKAESSRLQQAMQAKEMLNGEVEKGRRYGAPPAADLGLVKAASKAVPHPYESRHVVVHPGPADYSVRDASGVRASVMVLPNSSTPAADLEGQQVTHRENSPSALNDKSGLHLGKPGHRSYALSPQQVLGPEGVKAVATLSPHTVIQTTHSASEALPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGGLPPHLVIPGTQPLLIPVGSADLEGSGAASAIVTSSPQFAAVPHTFVTTALPKSENFGPEALVTQAAYPAMVQAQIHLPVAQSVASPAAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISTDLKIDSSTVERIADSHSPGVAVIQFAVGDHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGISQGSAQMLSENGELKFPEKIGLPATPLLTKIEPSKPAATRKRRWSAPETRKLEKSEDEPPLTLPKPSLISQEVKICIEGRSNVALQSFSRSKMLKVSKWFQGMNVNYELVCDNE", "length": 846, "header": "tr|E1BDF7-1|E1BDF7_BOVIN Computationally mapped isoform of Ataxin 1 OS=Bos taurus OX=9913 GN=ATXN1 PE=3 SV=5 CANONICAL=A0A3Q1M331-1" }, "locus": { "chromosome": "23", "start_pos": 40829583, "end_pos": 40810871, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044692.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044692.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000042169.5", "url": "https://www.ensembl.org/id/ENSBTAP00000042169.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y890-1", "protein_name": "Ataxin 1", "gene_name": "ATXN1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKSNQERSNECLPPKKREIPATSLPSEVKPVLPNDNHRTDNLAWLPGSQSSLGGRHRPGGTSAEVGLQQGLHKPPPAGLDYSPPSAPRSVPAPTTLPTVYSPALSQSGTPVSPVQYTHLQHTFQFVGPQYSGPYAGFIPSQLISPTANSATGAVAAATAVATTPSQRSQLEAYSTLLASMSGLSQQGHKVEPHLVRTPGLIAAGSPPPAQQNQYVHISSSPQSAVRNVSPPTIPVPLHPHQTVIPHTLTLGPSSQVVVQYSDASHFVTRDAPKKPESGRLQAMQAKEVLNGEIEKSRRYGISPSADMGLVKAGNKPAPHHYETRHVVVHSGPTDYGARESSGVRASVMVVPNSSTPTADLEVQQATNRENSPSTLNDKGSLHLGKPTHRSYALSPQQALGHEGVKAVATLSPHTVIQTTHSASEHLPVGLPATAFYAGTQPPVIGYLSSQQQALGYPGGLPQHLVIPGTQPLLIPVGSADVEPSGVTPAIVTSSPQFAAVPHTFVTTAVPKSEAFSAEPHTTQPAYQATMVQAQIHLPVVQSIASPATAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEESHNPGIAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSIKKGQPVDSASILLKHSKNDSLAGSRHRYAEQENGINQGSAQMLAENGELKFPDKIGLPAAPLLTKTEPSKPPATRKRRWSAPESRKLEKSEEEPPLTLPKPSFIPQEVKICIEGRSNVGK", "length": 798 }, "evidence": [ { "id": "A0A3Q1M331", "url": "https://omabrowser.org/oma/group/A0A3Q1M331/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RUJ3-1", "protein_name": "Ataxin 1", "gene_name": "ATXN1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKSNQERSNECLPPKKREIPATSRPSEDKATAVPSDNHRAEGVPWLPGHAGARGHAGGRLGPAGPPPELGLQQGIGLHKALSSGLDYSPPSAPRSVPATTTMPAAYPPPQSGAPVSPVQYAHLPAHPLQFIGSSQYSGPYTGFIPSQLISPTASPVTSAVASAAGAATPSQRSQLEAYSTLLATMGGLSQASGHKAEQPPPPPPPPQHLGRTAGLLPPGSPPPTPQNQYVHIAGSPQTAARPASPPAIPVHLHPHQTMIPHTLTLGPSPQVVVQYTDSGSHFVPREATKKAESSRLQQAMQAKEILNGELEKGRRYGAPTSADLGLVKAGGKAVPHPYESRHVVVHPSPADYGSRDSSGVRASVMVLPNSSTPAADLEVQQVTHREASPSTLNDKSGLHLGKPGHRSYALSPQQALGPEGVKAAAAAAAAVATLSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSSQQQAITYAGGLPQHLVIPGTQPLLIPVGSADMEGSGAASAIVTSSPQFAAVPHTFVTTALPKNENFSPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIENSHSPGVAVIQFAVGDHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKTDGLAGSRHRYAEQENGINQGGAQMLSENGELKFPEKIGLPAAPLLTKIEPSKPAATRKRRWSAPESRKLEKSEDEPPLTLPKPSLISQEVKICIEGRSNVGK", "length": 821 }, "evidence": [ { "id": "A0A3Q1M331", "url": "https://omabrowser.org/oma/group/A0A3Q1M331/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GUF4-1", "protein_name": "Ataxin-1", "gene_name": "Atxn1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKSNQERSNECLPPKKREIPATSRPSEEKATALPSDNHCVEGVAWLPSTPGSRSHGGGRHGPAGTSGELGLQGMGLHKALSAGLDYSPPSAPRSVPTATTLPAVYPPPPSGTPVSPVQYAHLSHTFQFIGSSQYSGPYAGFIPSQLISPSGNPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQAPGHKIEPPPQQHLSRAAGLVTPGSPPPTQQNQYIHISSSPQSSGRAASPPPIPVHLHPHQTMIPHTLTLGPSSQVVVQYSDAGGHFVPRESTKKAESSRLQQAMQAKEVLNGEMEKSRRYGAPSSVELSLGKASGKSVPHPYESRHVVVHPSPADYSSRDTSGVRGSVMVLPNNNTPSADLEAQQATHREASPSTLNDKSSLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSPDMDTPGAASAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHAKTDSLAGSRHRYAEQENGINQGGTQVLSENGELKFPEKVGLPAAPFLTKIEPSKPTATRKRRWSAPETRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK", "length": 790 }, "evidence": [ { "id": "A0A3Q1M331", "url": "https://omabrowser.org/oma/group/A0A3Q1M331/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P54253-1", "protein_name": "Ataxin-1", "gene_name": "ATXN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK", "length": 815 }, "evidence": [ { "id": "A0A3Q1M331", "url": "https://omabrowser.org/oma/group/A0A3Q1M331/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P54254-1", "protein_name": "Ataxin-1", "gene_name": "Atxn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKSNQERSNECLPPKKREIPATSRPSEEKATALPSDNHCVEGVAWLPSTPGIRGHGGGRHGSAGTSGEHGLQGMGLHKALSAGLDYSPPSAPRSVPTANTLPTVYPPPQSGTPVSPVQYAHLSHTFQFIGSSQYSGPYAGFIPSQLISPSGNPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQAPGHKVEPPPQQHLSRAAGLVNPGSPPPPTQQNQYIHISSSPQSSGRATSPPPIPVHLHPHQTMIPHTLTLGPSSQVVVQYSDAGGHFVPRESTKKAESSRLQQAMQAKEVLNGEMEKSRRYGASSSVELSLGKASSKSVPHPYESRHVVVHPSPADYSSRDTSGVRGSVMVLPNSSTPSADLEAQQTTHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGGLPQHLVIPGNQPLLIPVGSPDMDTPGAASAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPTTASPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEESHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKQAKTDSLAGSRHRYAEQENGINQGSAQVLSENGELKFPEKIGLPAAPFLSKIEPSKPTATRKRRWSAPETRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK", "length": 791 }, "evidence": [ { "id": "A0A3Q1M331", "url": "https://omabrowser.org/oma/group/A0A3Q1M331/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q63540-1", "protein_name": "Ataxin-1", "gene_name": "Atxn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKSNQERSNECLPPKKREIPATSRPSEEKATALPSDNHCVEGVAWLPSTPGSRGHGGGRHGPAGTSGEHGLQGMGLHKALSAGLDYSPPSAPRSVPTANTLPTVYPPPQSGTPVSPVQYAHLSHTFQFIGSSQYSGPYAGFIPSQLISPPGNPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQAPGHKVEPPPQQHLGRAAGLVNPGSPPPTQQNQYIHISSSPQSSGRATSPPIPVHLHPHQTMIPHTLTLGPSSQVVVQYSDAGGHFVPRESTKKAESSRLQQAMQAKEVLNGEMEKSRRYGASSSVELSLGKTSSKSVPHPYESRHVVVHPSPADYSSRDTSGVRGSVMVLPNSSTPSADLETQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGAQPPVIGYLSSQQQAITYAGGLPQHLVIPGTQPLLIPVGSPDMDTPGAASAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAASPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASALLKHAKTDSLAGSRHRYAEQENGINQGSAQVLSENGELKFPEKIGLPAAPFLTKIEPSKPTATRKRRWSAPETRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK", "length": 789 }, "evidence": [ { "id": "A0A3Q1M331", "url": "https://omabrowser.org/oma/group/A0A3Q1M331/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "POZ domain binding", "id": "GO:0031208", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031208", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "poly(U) RNA binding", "id": "GO:0008266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008266", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "poly(G) binding", "id": "GO:0034046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034046", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "nuclear matrix", "id": "GO:0016363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016363", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "nuclear inclusion body", "id": "GO:0042405", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042405", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "learning", "id": "GO:0007612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007612", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "memory", "id": "GO:0007613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007613", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "social behavior", "id": "GO:0035176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035176", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "nuclear export", "id": "GO:0051168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051168", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M331", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 694, "end_pos": 696, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M331" }, { "id": "PS51148", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51148" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AXH", "eco_id": "ECO_0000259", "start_pos": 564, "end_pos": 695, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 371, "end_pos": 373 }, { "start_pos": 694, "end_pos": 696 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M397-1", "uniprot_ac": "A0A3Q1M397", "uniprot_id": "A0A3Q1M397_BOVIN", "mass": { "chemical_mass": 99675.0, "monoisotopic_mass": 99675.0 }, "refseq": { "ac": "NP_001178050", "name": "villin-like protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178050" }, "gene_names": [ { "name": "VILL", "type": "recommended", "evidence": [ { "id": "A0A3Q1M397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M397" } ] }, { "name": "VILL", "type": "synonym", "evidence": [ { "id": "NP_001178050", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178050" } ] } ], "protein_names": [ { "name": "Villin like", "type": "synonym", "evidence": [ { "id": "A0A3Q1M397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M397/entry#names_and_taxonomy" } ] }, { "name": "villin-like protein", "type": "synonym", "evidence": [ { "id": "NP_001178050", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178050" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M397", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M397" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VILL", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M397", "locus": { "chromosome": "22", "start_pos": 11459404, "end_pos": 11441002, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012963", "url": "https://www.ensembl.org/id/ENSBTAG00000012963" } ] } } ], "crossref": [ { "id": "A0A3Q1M397", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M397", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012963", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012963", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11288", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11288", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11289", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11289", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11291", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11291", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11292", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11292", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11293", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11293", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "781105", "url": "https://www.ncbi.nlm.nih.gov/gene/781105", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036886", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036886", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781105", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781105", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LIFVWIG", "url": "https://omabrowser.org/oma/group/LIFVWIG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M397", "url": "https://www.orthodb.org/?gene=A0A3Q1M397", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11977", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11977", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11977:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11977:SF30", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00626", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00626", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02209", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02209", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178050", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M397", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M397", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M397-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M397-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXN1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXN1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXN1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEHNKDAVWRANGCLQSVCIACLMDTRRGLPDIESHRDLHIWIIENLQMVPVPEPAYGNFFEKHCYVVLHVPQSLKATPGVPKDLHYWVGKMAAPGAQGAPGSFLQHLKEALGGATVQHREVQGHESACFRSYFRSGIIYRKGGLASALKHVETNVYNIQRLLRIRGGKHVSATEVELSWHSFNNSDVFLLDLGRMMIQWNGPKASAARKARGLFLTHSLRDRERGGRAQVSVVDDEAEATDLMEIMEAVLGRRVGSLHAAMPSKRMNQLQKANVHLYQVCQKSKDLVVQELSTCPLTQDLLQEENCYILDQGGFKIYVWQGRRASLQERGAAFRRALNFIQAKGYPSYTSVEVMDDGAESAGFKQLFRSWSGQQRKNKNLSGMGKLLQVKLDVGKLHSQPELAAQLRMVDDASGSVQIWCIQDSHRQPVDPKRHGQLCADSCYLVLYTYRRMGFVQHVLYLWQGLQATAHEISALRGNAEELDLWYRGALVQEHVTMGSEPPHFLAIFQGQLVIFQGHPRHSRKGQPAPAVSLFHIQGTDSYNTRTMEVPARASALNSSDVFLLVTANLCYLWFGKGCSGDQREMARTVVTIICREDMEIVLEGQEPPNFWEALGGRAPYRSNKRPPEDVCDFQPRLFECSCQAGPLVLTEVVFFSQEDLDKYDVMLLDAWQEIFLWLGAAASEWKQEAVAWGQEYLKTHPAGRSLATPIVLVKQGHEPPTFIGWFCTWDPYKWSNTQSYEEVVAGDPGAVSTISEITAEIVNFRLSRWPGNDRAGPLALRALKSSEDISESELELGPRAGTGSRSTVSSASSSSYQSSPQSLGSGGLPREQLRHQAAEDLPEGVDPAHKEAYLSDSDFQDIFGKSKEEFYSMAKWRQQQEKQQLGFF", "length": 889, "header": "tr|A0A3Q1M397-1|A0A3Q1M397_BOVIN Isoform 1 of Villin like OS=Bos taurus OX=9913 GN=VILL PE=3 SV=1 CANONICAL=A0A3Q1M397-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M397-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M397/entry", "sequence": { "sequence": "MEHNKDAVWRANGCLQSVCIACLMDTRRGLPDIESHRDLHIWIIENLQMVPVPEPAYGNFFEKHCYVVLHVPQSLKATPGVPKDLHYWVGKMAAPGAQGAPGSFLQHLKEALGGATVQHREVQGHESACFRSYFRSGIIYRKGGLASALKHVETNVYNIQRLLRIRGGKHVSATEVELSWHSFNNSDVFLLDLGRMMIQWNGPKASAARKARGLFLTHSLRDRERGGRAQVSVVDDEAEATDLMEIMEAVLGRRVGSLHAAMPSKRMNQLQKANVHLYQVCQKSKDLVVQELSTCPLTQDLLQEENCYILDQGGFKIYVWQGRRASLQERGAAFRRALNFIQAKGYPSYTSVEVMDDGAESAGFKQLFRSWSGQQRKNKNLSGMGKLLQVKLDVGKLHSQPELAAQLRMVDDASGSVQIWCIQDSHRQPVDPKRHGQLCADSCYLVLYTYRRMGFVQHVLYLWQGLQATAHEISALRGNAEELDLWYRGALVQEHVTMGSEPPHFLAIFQGQLVIFQGHPRHSRKGQPAPAVSLFHIQGTDSYNTRTMEVPARASALNSSDVFLLVTANLCYLWFGKGCSGDQREMARTVVTIICREDMEIVLEGQEPPNFWEALGGRAPYRSNKRPPEDVCDFQPRLFECSCQAGPLVLTEVVFFSQEDLDKYDVMLLDAWQEIFLWLGAAASEWKQEAVAWGQEYLKTHPAGRSLATPIVLVKQGHEPPTFIGWFCTWDPYKWSNTQSYEEVVAGDPGAVSTISEITAEIVNFRLSRWPGNDRAGPLALRALKSSEDISESELELGPRAGTGSRSTVSSASSSSYQSSPQSLGSGGLPREQLRHQAAEDLPEGVDPAHKEAYLSDSDFQDIFGKSKEEFYSMAKWRQQQEKQQLGFF", "length": 889, "header": "tr|A0A3Q1M397-1|A0A3Q1M397_BOVIN Isoform 1 of Villin like OS=Bos taurus OX=9913 GN=VILL PE=3 SV=1 CANONICAL=A0A3Q1M397-1" }, "locus": { "chromosome": "22", "start_pos": 11459248, "end_pos": 11441352, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083387.1", "url": "https://www.ensembl.org/id/ENSBTAT00000083387.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067958.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067958.1" } ] } }, { "isoform_ac": "A0ABI0NXN1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXN1/entry", "sequence": { "sequence": "MDTRRGLPDIESHRDLHIWIIENLQMVPVPEPAYGNFFEKHCYVVLHVPQSLKATPGVPKDLHYWVGKMAAPGAQGAPGSFLQHLKEALGGATVQHREVQGHESACFRSYFRSGIIYRKGGLASALKHVETNVYNIQRLLRIRGGKHVSATEVELSWHSFNNSDVFLLDLGRMMIQWNGPKASAARKARGLFLTHSLRDRERGGRAQVSVVDDEAEATDLMEIMEAVLGRRVGSLHAAMPSKRMNQLQKANVHLYQVCQKSKDLVVQELSTCPLTQDLLQEENCYILDQGGFKIYVWQGRRASLQERGAAFRRALNFIQAKGYPSYTSVEVMDDGAESAGFKQLFRSWSGQQRKNKNLSGMGKLLQVKLDVGKLHSQPELAAQLRMVDDASGSVQIWCIQDSHRQPVDPKRHGQLCADSCYLVLYTYRRMGFVQHVLYLWQGLQATAHEISALRGNAEELDLWYRGALVQEHVTMGSEPPHFLAIFQGQLVIFQGHPRHSRKGQPAPAVSLFHIQGTDSYNTRTMEVPARASALNSSDVFLLVTANLCYLWFGKGCSGDQREMARTVVTIICREDMEIVLEGQEPPNFWEALGGRAPYRSNKRPPEDVCDFQPRLFECSCQAGPLVLTEVVFFSQEDLDKYDVMLLDAWQEIFLWLGAAASEWKQEAVAWGQEYLKTHPAGRSLATPIVLVKQGHEPPTFIGWFCTWDPYKWSNTQSYEEVVAGDPGAVSTISEITAEIVNFRLSRWPGNDRAGPLALRALKSSEDISESELELGPRAGTGSRSTVSSASSSSYQSSPQSLGSGGLPREQLRHQAAEDLPEGVDPAHKEAYLSDSDFQDIFGKSKEEFYSMAKWRQQQEKQQLGFF", "length": 866, "header": "tr|A0ABI0NXN1-1|A0ABI0NXN1_BOVIN Computationally mapped isoform of Villin like OS=Bos taurus OX=9913 GN=VILL PE=3 SV=1 CANONICAL=A0A3Q1M397-1" }, "locus": { "chromosome": "22", "start_pos": 11459248, "end_pos": 11443635, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144429.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144429.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104837.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104837.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:781105", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781105", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3Z8F1-1", "protein_name": "Villin-like", "gene_name": "Vill", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSNQVLPAINSHRALQIWITENLKMLPLPEKAHGNFFEECCYVVLHSPKATQGGSRDLHCWIGKEASTEAQEAAVSFMHRLQQDLGDQTVLHRESQGHESDCFHSYFRPGVIYRKGGRASALKLGESNVYNVQRLLHIRGRKHVSATEVALSWNSFNKGDIFLLDLGKVMIQWNGPKASICEKARALSLTCSLRDRERGGRAQIRVVDAENKATDLMSIMEAVLGRRSGSLCASVPSNSVSQLQKANIRLYHVFEKGTDLVVQELATRPLTQDLLQEDGCYLLDQGGFKIYMWQGRKSSPEERKAAFSRAVGFIQAKGYPNYTNVEVVNDGAESTAFQQLFWTWSKELNGKKHPRQSKLMQQVNLEVGKLHTQPELAAQLRMVDDGSGKVEVWYIQGSQRQPVDPKHHGQLCSGNCYLVLYKYQKLGRVQYILYLWQGHQSTVEDVKALNCNAEELDLLHQGALVQGHVTMGREPPHFLAIFQGQLVVLQGNAGNKGGRLPISDTRLFHVQGTESHNTRTMEVPARASSLTSSDVFFLITSHVCYLWFGKGCHGDQREMARTVVTVFPGNNKETVLEGQEPLHFWEALGGRAPYPSNKRLPEEISSIQPRLFECSSHSGHLVLTEVVFFGQEDLDKYDIMLLDTCQEIFLWLGEAAGEWKKAAVAWGHEYLRTHPAERSLATPIIVVKQGREPATFTGWFVTWDPYKWTSSQSYEEMVEGSLGPGSAISEITAEVHNFQLTARPSDSEAGRPTLLAFKGSQDSPENELELGLRVDGETPSMNHTSSCSSSMINGSLPRERLMHQALEDLPQGVDPARKEVGTRPNCWKTPRDPAP", "length": 836 }, "evidence": [ { "id": "A0A3Q1M397", "url": "https://omabrowser.org/oma/group/A0A3Q1M397/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O15195-1", "protein_name": "Villin-like protein", "gene_name": "VILL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQAGAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVETNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDKSIHVKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSNKRLPEEVPSFQPRLFECSSHMGCLVLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEAASEWKEAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGSPAAASTISEITAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSRTSSSVSSTSATINGGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF", "length": 856 }, "evidence": [ { "id": "A0A3Q1M397", "url": "https://omabrowser.org/oma/group/A0A3Q1M397/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91YD6-1", "protein_name": "Villin-like protein", "gene_name": "Vill", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDINQDLPAIDSHRALQIWITENLKMLPLPERAHGNFFEECCYVVLHVPQSPKATQGGSSDLHYWIGKDASAEAREAAVSFVQCLQEDLGDQTVLHRESQGHESDCFHSYFHPGVIYRKGGRDSALKFAETNMYNVQRLLHIKGRKHVSATEVALSWNSFNKGDIFLLDLGKVMIQWNGPKASISEKARALTLTCNLRDRERGGRAQIAVVDAENEATNLLRIMEAVLGCRSGSLCPSVPSNSVSQLQKANVRLYHVCEKGTDLVVQELATRPLTQDLLQEDGCYLLDQGGFKIYMWQGRKSSPQEKKAALSRAVGFIQAKGYPNYTNVEVVNDGAESTAFQQLFWSWSKELDRKKHPEKSKLVQGNLEVGKLHTQPELAAQLRMVDDGSGKVEVWYIQDLQRQPVHPKYYGQLCSGNCYLVLYTYQKLGCVQYLLYLWQGHQSTVEDTKALNCSAEELDLMHQGALAQGHVTMGSEPPHFLAIFQGRLVVFQGNAGNKGERPPVSDTRLFHVQGTESHNTRTMEVPARASSLTSGDVFFLITSHVCYLWFGKGCHGDQREMARTVVSVFPGNNKETVLEGQEPLYFWEALGGRAPYPSNKRLPEEVWSIQPRLFECSSHAGCLVLTEVLFFGQEDLDKYDIMLLDTCQEIFLWLGEAAGEWKKEAVAWGLEYLRTHPAERSLATPIFVVKQGHEPATFTGWFVTWDPYKWMNSQSYEEMVGNSLGPGSAISEMTAEVHNFQLTPRLSDNKAGHPALQAFKGSQDSPENELGLDLRVDGANPSMNHTSSCSDSMVNGSLPRERLMHQALEDLPPGVDPARKEFYLSDSDFQDIFGKSKEEFYSMAKWKQQQAKKKLGFF", "length": 859 }, "evidence": [ { "id": "A0A3Q1M397", "url": "https://omabrowser.org/oma/group/A0A3Q1M397/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M397", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M397" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M397", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M397" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M397", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M397" } ], "pmid": "" } ] }, { "name": "Biological Process", 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377343" }, "gene_names": [ { "name": "OR51A57", "type": "recommended", "evidence": [ { "id": "A0A3Q1M3V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3V9" } ] }, { "name": "OR51A57", "type": "synonym", "evidence": [ { "id": "NP_001377343", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377343" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0A3Q1M3V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3V9/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 51 subfamily A member 57", "type": "synonym", "evidence": [ { "id": "NP_001377343", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377343" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377343" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3V9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3V9#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3V9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3V9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR51A57", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3V9", "locus": { "chromosome": "15", "start_pos": 50355200, "end_pos": 50354334, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000059960", "url": "https://www.ensembl.org/id/ENSBTAG00000059960" } ] } } ], "crossref": [ { "id": "A0A3Q1M3V9", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M3V9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051654", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051654", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "785068", "url": "https://www.ncbi.nlm.nih.gov/gene/785068", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785068", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785068", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF141", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF141", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377343", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3V9", "url": 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"pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M3V9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 288, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M3V9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M3V9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M3V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3V9" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 75, "end_pos": 288, "start_aa": "Gly", "end_aa": "Leu", 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"database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807971" } ] } ], "protein_names": [ { "name": "Estrogen related receptor beta", "type": "synonym", "evidence": [ { "id": "A0A3Q1M3W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3W3/entry#names_and_taxonomy" } ] }, { "name": "steroid hormone receptor ERR2 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_010807971", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807971" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3W3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ESRRB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3W3", "locus": { 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"https://www.ebi.ac.uk/interpro/entry/IPR000536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027289", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027289", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528437", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528437", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WNGVRRD", "url": "https://omabrowser.org/oma/group/WNGVRRD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3W3", "url": "https://www.orthodb.org/?gene=A0A3Q1M3W3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48092", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48092", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00104", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00104", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00105", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00105", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010807971", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010807971", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3W3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3W3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3W3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLN0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLN0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLN0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDVSELCVPDPLGYHNQLLNRMSADDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGAHANGLDSPPMFAGAGLGGTPCRKGYEDCAGGLMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSNLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPRRTGKLLLTLPLLRQTAAKAVQHFYSIKLQGKVPMHKLFLEMLEAKV", "length": 454, "header": "tr|A0A3Q1M3W3-1|A0A3Q1M3W3_BOVIN Isoform 1 of Estrogen related receptor beta OS=Bos taurus OX=9913 GN=ESRRB PE=3 SV=1 CANONICAL=A0A3Q1M3W3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3W3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3W3/entry", "sequence": { "sequence": "MDVSELCVPDPLGYHNQLLNRMSADDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGAHANGLDSPPMFAGAGLGGTPCRKGYEDCAGGLMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSNLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPRRTGKLLLTLPLLRQTAAKAVQHFYSIKLQGKVPMHKLFLEMLEAKV", "length": 454, "header": "tr|A0A3Q1M3W3-1|A0A3Q1M3W3_BOVIN Isoform 1 of Estrogen related receptor beta OS=Bos taurus OX=9913 GN=ESRRB PE=3 SV=1 CANONICAL=A0A3Q1M3W3-1" }, "locus": { "chromosome": "10", "start_pos": 87809894, "end_pos": 87697993, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068282.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068282.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068235.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068235.1" } ] } }, { "isoform_ac": "A0ABI0NLN0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLN0/entry", "sequence": { "sequence": "MLLNRMSADDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGAHANGLDSPPMFAGAGLGGTPCRKGYEDCAGGLMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSNLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPRRTGKLLLTLPLLRQTAAKAVQHFYSIKLQGKVPMHKLFLEMLEAKV", "length": 438, "header": "tr|A0ABI0NLN0-1|A0ABI0NLN0_BOVIN Computationally mapped isoform of Estrogen related receptor beta OS=Bos taurus OX=9913 GN=ESRRB PE=3 SV=1 CANONICAL=A0A3Q1M3W3-1" }, "locus": { "chromosome": "10", "start_pos": 87809894, "end_pos": 87627056, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128910.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128910.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105724.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105724.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:528437", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528437", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PDM1-1", "protein_name": "Estrogen related receptor beta", "gene_name": "ESRRB", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLLGRMATEERHLSSSCGSFIKTEPSSPSSGIDAISHHSPSGSSDASGGYGIAMGGHPNGLDSPPMFNGTGIGGGSCRKRYDDCASAIMEDSPTKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSTYLSLQIPPPAKKPLTKIVSHLLVAEPEKIYAMPDPTMPESDIKALTTLCDLADRELVVIIGWAKHIPGFSNLSLGDQMSLLQSAWMEILILGIVYRSLPYEDKLVYAEDYIMDEEHSRLTGLLELYLAILQLVRRYKKLKVEKEEFVTLKALALANSDSMHIEDMDAVQKLQDLLHEALQDYELSQRNEEPRRAGKLLLTLPLLRQTAAKAVQHFYSIKLQGKVPMHKLFLEMLEAKV", "length": 438 }, "evidence": [ { "id": "A0A3Q1M3W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M3W3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A4X1T800-1", "protein_name": "Estrogen related receptor beta", "gene_name": "ESRRB", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLLNRMSADDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGAHANGLDSPPMFAGAGLGGTPCRKGYEDCASGLMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSNLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPRRTGKLLLTLPLLRQTAAKAVQHFYSIKLQGKVPMHKLFLEMLEAKV", "length": 438 }, "evidence": [ { "id": "A0A3Q1M3W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M3W3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P11475-1", "protein_name": "Steroid hormone receptor ERR2", "gene_name": "Esrrb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSEDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGMALGTHANGLDSPPMFAGAGLGGNPCRKSYEDCTSGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSENSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPDDVPEGDIKALTTLCDLADRELVFLISWAKHIPGFSNLTLGDQMSLLQSAWMEILILGIVYRSLPYDDKLAYAEDYIMDEEHSRLVGLLELYRAILQLVRRYKKLKVEKEEFVMLKALALANSDSMYIENLEAVQKLQDLLHEALQDYELSQRHEEPRRAGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKV", "length": 433 }, "evidence": [ { "id": "A0A3Q1M3W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M3W3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61539-1", "protein_name": "Steroid hormone receptor ERR2", "gene_name": "Esrrb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSEDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGIALSTHANGLDSPPMFAGAGLGGNPCRKSYEDCTSGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYNCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSENSPYLNLPISPPAKKPLTKIVSNLLGVEQDKLYAMPPNDIPEGDIKALTTLCELADRELVFLINWAKHIPGFPSLTLGDQMSLLQSAWMEILILGIVYRSLPYDDKLAYAEDYIMDEEHSRLVGLLDLYRAILQLVRRYKKLKVEKEEFMILKALALANSDSMYIENLEAVQKLQDLLHEALQDYELSQRHEEPRRAGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKV", "length": 433 }, "evidence": [ { "id": "A0A3Q1M3W3", "url": "https://omabrowser.org/oma/group/A0A3Q1M3W3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3W3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3W3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3W3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3W3" } ], "pmid": "" }, { "name": "nuclear steroid receptor activity", "id": "GO:0003707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003707", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3W3" } ], "pmid": "" }, { "name": "steroid binding", "id": "GO:0005496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005496", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3W3" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3W3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3W3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M3W3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 454, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF03951", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "36683", "url": "https://www.rhea-db.org/rhea/36683", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M403", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M403-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATSVSSHLNKGIKQVYMALPQGDKVQAMYIWIDSTGEGLRCKTRTLDSEPKCIEELPEWNFDGSSTFQSEGSNSDMYLVPTAMFRDPFHKDPNKLVFCEVFKYNRKPAETNLRHTCKRIMDMMSNQRPWFGMEQKYTLMGTGGHPFGWPSNGFPGPQGPYYCGVGVDKAYGRDIVEAHYRACLYTGIKIGGTNTEVMPAQWEFQIGPCEGIDMGDHLWVARFILHRVCEDFGVIATFDSKPNPGNWNGAGCHTNFSTKAMRENGLKYIEEAIEKLSKRHQYHTRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRGASIRIPRTVGQEKKGYFEDLRPSANCDPFAVTEALIHTCLLNETGDEPFQYKN", "length": 372, "header": "tr|A0A3Q1M403-1|A0A3Q1M403_BOVIN Isoform 1 of Glutamine synthetase OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0A3Q1M403-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M403-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403/entry", "sequence": { "sequence": "MATSVSSHLNKGIKQVYMALPQGDKVQAMYIWIDSTGEGLRCKTRTLDSEPKCIEELPEWNFDGSSTFQSEGSNSDMYLVPTAMFRDPFHKDPNKLVFCEVFKYNRKPAETNLRHTCKRIMDMMSNQRPWFGMEQKYTLMGTGGHPFGWPSNGFPGPQGPYYCGVGVDKAYGRDIVEAHYRACLYTGIKIGGTNTEVMPAQWEFQIGPCEGIDMGDHLWVARFILHRVCEDFGVIATFDSKPNPGNWNGAGCHTNFSTKAMRENGLKYIEEAIEKLSKRHQYHTRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRGASIRIPRTVGQEKKGYFEDLRPSANCDPFAVTEALIHTCLLNETGDEPFQYKN", "length": 372, "header": "tr|A0A3Q1M403-1|A0A3Q1M403_BOVIN Isoform 1 of Glutamine synthetase OS=Bos taurus OX=9913 GN= PE=3 SV=1 CANONICAL=A0A3Q1M403-1" }, "locus": { "chromosome": "24", "start_pos": 43852121, "end_pos": 43851006, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065739.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065739.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064914.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064914.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q8LCE1-1", "protein_name": "Glutamine synthetase cytosolic isozyme 1-2", "gene_name": "GLN1-2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSLLADLVNLDISDNSEKIIAEYIWVGGSGMDMRSKARTLPGPVTDPSKLPKWNYDGSSTGQAPGQDSEVILYPQAIFKDPFRRGNNILVMCDAYTPAGEPIPTNKRHAAAEIFANPDVIAEVPWYGIEQEYTLLQKDVNWPLGWPIGGFPGPQGPYYCSIGADKSFGRDIVDAHYKASLYAGINISGINGEVMPGQWEFQVGPSVGISAADEIWIARYILERITEIAGVVVSFDPKPIPGDWNGAGAHTNYSTKSMREEGGYEIIKKAIEKLGLRHKEHISAYGEGNERRLTGHHETADINTFLWGVANRGASIRVGRDTEKEGKGYFEDRRPASNMDPYVVTSMIAETTLLWNP", "length": 356 }, "evidence": [ { "id": "A0A3Q1M403", "url": "https://omabrowser.org/oma/group/A0A3Q1M403/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M403", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ], "pmid": "" }, { "name": "glutamine biosynthetic process", "id": "GO:0006542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006542", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M403", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M403", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ], "pmid": "" }, { "name": "protein-cysteine S-palmitoyltransferase activity", "id": "GO:0019706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019706", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M403", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ], "pmid": "" }, { "name": "glutamine synthetase activity", "id": "GO:0004356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004356", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M403", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M403", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M403", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M403", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 255, "end_pos": 257, "annotation": "n_glycosylation_sequon" }, { "start_pos": 361, "end_pos": 363, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "36683", "name": "", "equation": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3X756-1", "E1BPA5-1", "F1MVC6-1", "E1B987-1", "E1BJK1-1", "F6R785-1", "A0AAA9TDW4-1", "A0AAA9TVJ9-1", "A0AAA9TM40-1", "E1B6X9-1", "E1BKA0-1", "E1BK60-1", "Q58CU4-1", "A2VDT6-1", "A0AAF6ZH94-1", "A0AAA9RZ07-1", "Q0VC89-1", "E1BLT8-1", "G3MXF3-1", "P15103-1", "Q2HJ95-1", "Q58DA8-1", "A0A3Q1M794-1", "A0A3Q1LVW6-1", "Q58DT3-1", "A0A3Q1M403-1", "A0ABI0NXA5-1" ], "evidence": [ { "id": "36683", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36683" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LVW6", "gene_name": "ZDHHC13", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1LVW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1LVW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVW6" } ] } ] }, { "uniprot_ac": "A0A3Q1M403", "gene_name": "", "activity": [ { "ec_number": "6.3.1.2", "activity": "L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] }, { "ec_number": "6.3.1.2", "activity": "", "evidence": [ { "id": "A0A3Q1M403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M403" } ] } ] }, { "uniprot_ac": "A0A3Q1M794", "gene_name": "ZDHHC3", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0A3Q1M794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M794" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0A3Q1M794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M794" } ] } ] }, { "uniprot_ac": "A0AAA9RZ07", "gene_name": "ZDHHC8", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9RZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ07" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9RZ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ07" } ] } ] }, { "uniprot_ac": "A0AAA9TDW4", "gene_name": "ZDHHC7", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW4" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDW4" } ] } ] }, { "uniprot_ac": "A0AAA9TM40", "gene_name": "ZDHHC18", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TM40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM40" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TM40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM40" } ] } ] }, { "uniprot_ac": "A0AAA9TVJ9", "gene_name": "ZDHHC23", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAA9TVJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVJ9" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAA9TVJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVJ9" } ] } ] }, { "uniprot_ac": "A0AAF6ZH94", "gene_name": "ZDHHC9", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0AAF6ZH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0AAF6ZH94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZH94" } ] } ] }, { "uniprot_ac": "A0ABI0NXA5", "gene_name": "ZDHHC15", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A0ABI0NXA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXA5" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A0ABI0NXA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXA5" } ] } ] }, { "uniprot_ac": "A2VDT6", "gene_name": "ZDHHC21", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "A2VDT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT6" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "A2VDT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT6" } ] } ] }, { "uniprot_ac": "E1B6X9", "gene_name": "ZDHHC12", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1B6X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X9" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1B6X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X9" } ] } ] }, { "uniprot_ac": "E1B987", "gene_name": "ZDHHC22", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1B987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B987" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1B987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B987" } ] } ] }, { "uniprot_ac": "E1BJK1", "gene_name": "ZDHHC17", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1BJK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJK1" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1BJK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJK1" } ] } ] }, { "uniprot_ac": "E1BK60", "gene_name": "ZDHHC14", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1BK60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK60" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1BK60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK60" } ] } ] }, { "uniprot_ac": "E1BKA0", "gene_name": "ZDHHC4", "activity": [ { "ec_number": "2.3.1.225", "activity": "L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA.", "evidence": [ { "id": "E1BKA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKA0" } ] }, { "ec_number": "2.3.1.225", "activity": "", "evidence": [ { "id": "E1BKA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKA0" } ] } ] }, { "uniprot_ac": "E1BLT8", "gene_name": "ZDHHC5", "activity": [ 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"MKNKTVLTEFILLGLTDVPELQVMVFIFLFLTYLLSIIGNLTILILTLLDSHLQTSMYFFLRNFSFLEISFTSIFIPRVLISITIGNKSISFAGCFAECFFAIFLGATEFYLLAAMSYDRYVAVCKPLHYTTTMSSKVCTQLVLCSWLAGLMVIISPITLMSQQDFCESNRLNHYFCDYEPLRELSCSDTNLIQKVAFLVASVTLVVTLVLVILSYTSIIRTILKLPSVHQRTNAFSTCSSHLVVISLSYGSCFFIYVKPTAKEVDTFNKGVALLSTSAAPLLNPFIYTLRNQQVKQAFKDTVQKLVNLKEFHN", "length": 314, "header": "tr|A0A3Q1M415-1|A0A3Q1M415_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6C8 PE=3 SV=1 CANONICAL=A0A3Q1M415-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M415-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M415/entry", "sequence": { "sequence": "MKNKTVLTEFILLGLTDVPELQVMVFIFLFLTYLLSIIGNLTILILTLLDSHLQTSMYFFLRNFSFLEISFTSIFIPRVLISITIGNKSISFAGCFAECFFAIFLGATEFYLLAAMSYDRYVAVCKPLHYTTTMSSKVCTQLVLCSWLAGLMVIISPITLMSQQDFCESNRLNHYFCDYEPLRELSCSDTNLIQKVAFLVASVTLVVTLVLVILSYTSIIRTILKLPSVHQRTNAFSTCSSHLVVISLSYGSCFFIYVKPTAKEVDTFNKGVALLSTSAAPLLNPFIYTLRNQQVKQAFKDTVQKLVNLKEFHN", "length": 314, "header": "tr|A0A3Q1M415-1|A0A3Q1M415_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6C8 PE=3 SV=1 CANONICAL=A0A3Q1M415-1" }, "locus": { "chromosome": "5", "start_pos": 57674653, "end_pos": 57673712, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072181.1", "url": "https://www.ensembl.org/id/ENSBTAT00000072181.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064524.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064524.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515967", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515967", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZV34-1", "protein_name": "Olfactory receptor", "gene_name": "Or6c8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNNKTLLTEFILLGLTDVPELQVAVFTFLFLAYIFSMIGNLTILILTLLDSHLHTPMYFFLRNFSFLEISFTNIFIPRVLVSITTGNKSISFAGCFAQYFFAIFLGATEFYLLAAMSYDRYVAICKPLHYMTIMSNKICTQLVLCSWLSGLMVIIPPITLMSQQDFCASNRLNHYFCDFEPLRELSCSDTNLIEKVVFLVASVTLVVTLMLVTLSYTFIIKTILKLPSVQQRTKAFSTCSSHMIVISLSYGSCFFMYVKPSAKEGGTFNKGVALLITSVAPLLNPFIYTLRNQQVRQAFKDTVKKLLNH", "length": 309 }, "evidence": [ { "id": "A0A3Q1M415", "url": "https://omabrowser.org/oma/group/A0A3Q1M415/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NGE2-1", "protein_name": "Olfactory receptor 2AP1", "gene_name": "OR2AP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKNKTVLTEFILLGLTDVPELQVAVFTFLFLAYLLSILGNLTILILTLLDSHLQTPMYFFLRNFSFLEISFTNIFIPRVLISITTGNKSISFAGCFTQYFFAMFLGATEFYLLAAMSYDRYVAICKPLHYTTIMSSRICIQLIFCSWLGGLMAIIPTITLMSQQDFCASNRLNHYFCDYEPLLELSCSDTSLIEKVVFLVASVTLVVTLVLVILSYAFIIKTILKLPSAQQRTKAFSTCSSHMIVISLSYGSCMFMYINPSAKEGDTFNKGVALLITSVAPLLNPFIYTLRNQQVKQPFKDMVKKLLNL", "length": 309 }, "evidence": [ { "id": "A0A3Q1M415", "url": "https://omabrowser.org/oma/group/A0A3Q1M415/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VG33-1", "protein_name": "Olfactory receptor", "gene_name": "Or6c8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKNKTSLTEFILLGLTDVPELQVAVFTFLFLAYVFSMIGNLTILILTLLDSHLHTPMYFFLRNFSFLEISFTNIFIPRVLVSITTGNKSISFAGCFAQYFFAIFLGATEFYLLAAMSYDRYVAICKPLHYMAIMSNRVCTHLVLCSWLGGLMAIIPPITLMSQQNFCASNRLNHYFCDFEPLLELSCSDTSLIEKVVFLVASVTLVVTLMLVTLSYTFIIKTILKLPSAQQRTKAFSTCSSHMIVISLSYGSCFFMYVKPSAKVGGTFDKGVALLITSVAPLLNPFIYTLRNQQVKQAFKDTVKKLVNL", "length": 309 }, "evidence": [ { "id": "A0A3Q1M415", "url": "https://omabrowser.org/oma/group/A0A3Q1M415/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M415", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M415" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M415", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M415" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M415", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M415" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M415-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 314, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M415-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M415" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M415", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M415" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 288, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 3, "end_pos": 5 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 63, "end_pos": 65 }, { "start_pos": 87, "end_pos": 89 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", 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"field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M420-1", "uniprot_ac": "A0A3Q1M420", "uniprot_id": "A0A3Q1M420_BOVIN", "mass": { "chemical_mass": 131131.0, "monoisotopic_mass": 131131.0 }, "refseq": { "ac": "XP_005225664", "name": "SMC5-SMC6 complex localization factor protein 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225664" }, "gene_names": [ { "name": "SLF2", "type": "recommended", "evidence": [ { "id": "A0A3Q1M420", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M420" } ] }, { "name": "C26H10ORF6", "type": "synonym", "evidence": [ { "id": "XP_005225664", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225664" } ] }, { "name": "FAM178A", "type": "synonym", "evidence": [ { "id": "XP_005225664", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225664" } ] }, { "name": "SLF2", "type": "synonym", "evidence": [ { "id": "XP_005225664", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225664" } ] } ], "protein_names": [ { "name": "SMC5-SMC6 complex localization factor 2", "type": "synonym", "evidence": [ { "id": "A0A3Q1M420", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M420/entry#names_and_taxonomy" } ] }, { "name": "SMC5-SMC6 complex localization factor protein 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005225664", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225664" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M420", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M420" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M420", "locus": { "chromosome": "26", "start_pos": 21802848, "end_pos": 21762858, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012077", "url": "https://www.ensembl.org/id/ENSBTAG00000012077" } ] } } ], "crossref": [ { "id": "A0A3Q1M420", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M420", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012077", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012077", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "541239", "url": "https://www.ncbi.nlm.nih.gov/gene/541239", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HYLVQMK", "url": "https://omabrowser.org/oma/group/HYLVQMK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M420", "url": "https://www.orthodb.org/?gene=A0A3Q1M420", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16046", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16046", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16046:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16046:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14816", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14816", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005225664", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225664", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M420", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M420", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M420-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M420-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTRRCMPARPGFPSSPAPGSSPPRCHLRPGSTVPAAAGKKTERPGDRKQSIIDFFKPASKQDRRMLDSPQKSNIKYGESGLSISGTEQFERKLSSPKSSKPKRVPSEKSPVLEAFIKGVKEHHRDRGVHESRQPCVSLDTKYSKAVTKYVPPSYLLSKETKKKHQSPEGRKSHFIHENSREKNDGNRGRISADSKKQATVTEADIFKNSSRSLSSRSSLSRHHPGESPLGAKFQLSLASYCRERELKRLRREQMEQRINSENSFSEASNLSLKSSSIERKCKPRQELSKQNDVTAGNSNLSNLENGHLSRKRSSSDSWGPTSAGSKQNKFPDKRKRNSVDSDLKSTRESIMPKAKESFLEKRPDGPHQKEKFIKHIALKTPGDVLRLEDISKDPSEEADCSSAGLTPTNSGHQIRGSDQNRVASTKETKIPKPHLSLPQEKSAVKKASNLQKNKTASSVASQETKLLPLLSHVPSAGSSRVPLNAKNCTLPVPKKDKERSSPKECSGHSTESSKHKEHKAKTNKADSNISSGKISEGSLRSEYGTPTKSPPAALEVVPCIPSPSAPSDKAPSDKESSGNSNAGSSALKRKLRGDFDSDEESLGYNLESDEEEETLKSLEEIMALNFNQTPTATGKPPALSKGLRSQSSDYTEHAHSGTYTNTLERLVKEMEDTHRLDELQKQLQEDIRQGRGIKSPIRIGDHDSTDDEDGLLEEHKEFLKKFSITIDAIPDHHPGEEIFNFLNSGKIFSQYTLDLRDSGFIGQSAVEKLILKSGKTDQIFLTTQGFLTSAYHYVQCPVPVLKWLFRMMSVHTDCIVSMQILSTLMEITIRNDTFSDSPIWPWIPSLSDIAAVFFNMGIDFRSLFPLENLQPDFNEDNLVSETQMTLGVKENEDSSYKPIFSSLPETNILNVVKFLGLCTSIHPEGYQDREIMLLILMLFKMSLEKELKQIPLVDFQSLLINLMKNIRDWNTKVPELSLAINELSTHPHNLLWLVQLVPNWTSRGRQLRQCLSLVIISKLLDEKREDIPNVNNLQISVLHRYLVQMKPSDLLKKMVLKKRAEQPNSTIDDSLHLELEKQAYYLTYILLHLIGEVSCSHSFSSGQRKHFVHLCGALEKHVKCDIREDARLFYRTKVKDLVARIHGKWQEIIQNCRPTQGQLHDFWVPDS", "length": 1167, "header": "tr|A0A3Q1M420-1|A0A3Q1M420_BOVIN Isoform 1 of SMC5-SMC6 complex localization factor 2 OS=Bos taurus OX=9913 GN=SLF2 PE=3 SV=1 CANONICAL=A0A3Q1M420-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M420-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M420/entry", "sequence": { "sequence": "MTRRCMPARPGFPSSPAPGSSPPRCHLRPGSTVPAAAGKKTERPGDRKQSIIDFFKPASKQDRRMLDSPQKSNIKYGESGLSISGTEQFERKLSSPKSSKPKRVPSEKSPVLEAFIKGVKEHHRDRGVHESRQPCVSLDTKYSKAVTKYVPPSYLLSKETKKKHQSPEGRKSHFIHENSREKNDGNRGRISADSKKQATVTEADIFKNSSRSLSSRSSLSRHHPGESPLGAKFQLSLASYCRERELKRLRREQMEQRINSENSFSEASNLSLKSSSIERKCKPRQELSKQNDVTAGNSNLSNLENGHLSRKRSSSDSWGPTSAGSKQNKFPDKRKRNSVDSDLKSTRESIMPKAKESFLEKRPDGPHQKEKFIKHIALKTPGDVLRLEDISKDPSEEADCSSAGLTPTNSGHQIRGSDQNRVASTKETKIPKPHLSLPQEKSAVKKASNLQKNKTASSVASQETKLLPLLSHVPSAGSSRVPLNAKNCTLPVPKKDKERSSPKECSGHSTESSKHKEHKAKTNKADSNISSGKISEGSLRSEYGTPTKSPPAALEVVPCIPSPSAPSDKAPSDKESSGNSNAGSSALKRKLRGDFDSDEESLGYNLESDEEEETLKSLEEIMALNFNQTPTATGKPPALSKGLRSQSSDYTEHAHSGTYTNTLERLVKEMEDTHRLDELQKQLQEDIRQGRGIKSPIRIGDHDSTDDEDGLLEEHKEFLKKFSITIDAIPDHHPGEEIFNFLNSGKIFSQYTLDLRDSGFIGQSAVEKLILKSGKTDQIFLTTQGFLTSAYHYVQCPVPVLKWLFRMMSVHTDCIVSMQILSTLMEITIRNDTFSDSPIWPWIPSLSDIAAVFFNMGIDFRSLFPLENLQPDFNEDNLVSETQMTLGVKENEDSSYKPIFSSLPETNILNVVKFLGLCTSIHPEGYQDREIMLLILMLFKMSLEKELKQIPLVDFQSLLINLMKNIRDWNTKVPELSLAINELSTHPHNLLWLVQLVPNWTSRGRQLRQCLSLVIISKLLDEKREDIPNVNNLQISVLHRYLVQMKPSDLLKKMVLKKRAEQPNSTIDDSLHLELEKQAYYLTYILLHLIGEVSCSHSFSSGQRKHFVHLCGALEKHVKCDIREDARLFYRTKVKDLVARIHGKWQEIIQNCRPTQGQLHDFWVPDS", "length": 1167, "header": "tr|A0A3Q1M420-1|A0A3Q1M420_BOVIN Isoform 1 of SMC5-SMC6 complex localization factor 2 OS=Bos taurus OX=9913 GN=SLF2 PE=3 SV=1 CANONICAL=A0A3Q1M420-1" }, "locus": { "chromosome": "26", "start_pos": 21800816, "end_pos": 21763008, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072997.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072997.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064934.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064934.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 321, "start_aa": "Thr", "end_pos": 321, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr321", "evidence": [ { "id": 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377401" }, "gene_names": [ { "name": "OR7G44", "type": "recommended", "evidence": [ { "id": "A0A3Q1M431", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M431" } ] }, { "name": "OR7G44", "type": "synonym", "evidence": [ { "id": "NP_001377401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377401" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0A3Q1M431", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M431/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 7G1", "type": "synonym", "evidence": [ { "id": "NP_001377401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377401" } ] }, { "name": "olfactory receptor family 7 subfamily G member 44", "type": "synonym", "evidence": [ { "id": "NP_001377401", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377401" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377401" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M431", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M431#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M431", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M431" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR7G44", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M431", "locus": { "chromosome": "7", "start_pos": 13443982, "end_pos": 13444935, 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"http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23115", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00009", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03144", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03144", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08938", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08938", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22594", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22594", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-429958", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-429958", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", 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{ "id": "A0AAA9TIP7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TIP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS84", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TS84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS84-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1V0", "url": "https://www.uniprot.org/uniprotkb/F1N1V0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N1V0-1", "url": "https://www.uniprot.org/uniprotkb/F1N1V0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VLGNKNSRGEAYFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSAVEPVEEYDYEDLKEFSSSLVNHQLSGIDQARLYSCLDHMREVLGDAVPDDILIEAVLKNKFDVQKALSVVLEQDKVQNLKVRSEGAISTGKIAKGKSIDSQSSQSESEIVPKVTKMTVSGKKQTMGFEVPRVTAEENGHSFHTPQKGHSSEDTSLVSSDALESASKSALPSHTIQASEEQSSTPTPVKKSGKLRQQIDIKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHLLYLLGDVNKRTMHKYEQESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETKTKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQVNWQQERFQEITGKLGHFLKQAGFKESDVAFIPTSGLSGENLITRSQSSELTKWYKGLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCVTGKIEAGYIQTGDRLLAMPPNETCTAKGITLHDEPVDWAAAGDHVSLTLVGMDIIKINVGCIFCVPKEPIKVCTRFRARILIFNIEIPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTKKKPKLLTKGQNALVELQTQRPVALELYKDFKELGRFMLRYSGSTIAAGVVTEVF", "length": 682, "header": "tr|A0A3Q1M492-1|A0A3Q1M492_BOVIN Isoform 1 of HBS1-like protein OS=Bos taurus OX=9913 GN=HBS1L PE=3 SV=2 CANONICAL=A0A3Q1M492-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M492-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M492/entry", "sequence": { "sequence": "VLGNKNSRGEAYFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSAVEPVEEYDYEDLKEFSSSLVNHQLSGIDQARLYSCLDHMREVLGDAVPDDILIEAVLKNKFDVQKALSVVLEQDKVQNLKVRSEGAISTGKIAKGKSIDSQSSQSESEIVPKVTKMTVSGKKQTMGFEVPRVTAEENGHSFHTPQKGHSSEDTSLVSSDALESASKSALPSHTIQASEEQSSTPTPVKKSGKLRQQIDIKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHLLYLLGDVNKRTMHKYEQESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETKTKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQVNWQQERFQEITGKLGHFLKQAGFKESDVAFIPTSGLSGENLITRSQSSELTKWYKGLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCVTGKIEAGYIQTGDRLLAMPPNETCTAKGITLHDEPVDWAAAGDHVSLTLVGMDIIKINVGCIFCVPKEPIKVCTRFRARILIFNIEIPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTKKKPKLLTKGQNALVELQTQRPVALELYKDFKELGRFMLRYSGSTIAAGVVTEVF", "length": 682, "header": "tr|A0A3Q1M492-1|A0A3Q1M492_BOVIN Isoform 1 of HBS1-like protein OS=Bos taurus OX=9913 GN=HBS1L PE=3 SV=2 CANONICAL=A0A3Q1M492-1" }, "locus": { "chromosome": "9", "start_pos": 73090939, "end_pos": 73013426, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073195.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073195.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065011.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065011.2" } ] } }, { "isoform_ac": "A0AAA9STH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STH3/entry", "sequence": { "sequence": "MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSAVEPVEEYDYEDLKEFSSSLVNHQLSGIDQARLYSCLDHMREVLGDAVPDDILIEAVLKNKFDVQKALSVVLEQDKVQNLKVRSEGAISTGKIAKGVLLSSSEVSADNVHSSCPQSANHLDCSSKSFDFSGPVAKYGLYHNSSVIPSHYLLHKKKKLDRPKSEKKLES", "length": 217, "header": "tr|A0AAA9STH3-1|A0A3Q1M492_BOVIN Computationally mapped isoform of HBS1-like protein OS=Bos taurus OX=9913 GN=HBS1L PE=3 SV=1 CANONICAL=A0A3Q1M492-1" }, "locus": { "chromosome": "9", "start_pos": 73095936, "end_pos": 73075663, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096941.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096941.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087267.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087267.1" } ] } }, { "isoform_ac": "A0AAA9T6S6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6S6/entry", "sequence": { "sequence": "MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSAVEPVEEYDYEDLKEFSSSLVNHQLSGIDQARLYSCLDHMREVLGDAVPDDILIEAVLKNKFDVQKALSVVLEQDKVQNLKVRSEGAISTGKIAKGVLLSSSEVSADNVHSSCPQSANHLDCSSKSFDFSGPVAKYGLYHNSSVIPSHYLLHKKKKLDRPKSEKKLESCKLTKDLSLADLINDMPRDSYKSQPSVRLPPTDSVESLPSKSLDGDLLRPHVSECISKDDSAFKGIPDLKSLMIKNTAPNNSSTIQNDSVPDLQNIPVQNSLGSLNNPSLENMALDNLNASKTTEVGIVSSVEQSNKNCILKSDNLQFSQCESPSLAELFEEHKKNNPSECFTLPDFCHQPSSSFTDLSLGSFPLSQLANRYQSSTGISELTGSLSSLAFCKASPTRDLENLSLSDLIAETIDIDNPQIRKDSCMLSLSEMRSPGIDSNIDLSVLIKAPDFVPKPVVDQSVAPIPETKVLSSKLGKNSNSAKDNKKNSKSSLPRKPPFSLSWTKALAARPSAFASTLCLRYPLKSCKRRTFDLYKAFLYSRQVQDVKDKEISPLIAITPFDFKSASPDDIVKANQKKAFTRE", "length": 629, "header": "tr|A0AAA9T6S6-1|A0A3Q1M492_BOVIN Computationally mapped isoform of HBS1-like protein OS=Bos taurus OX=9913 GN=HBS1L PE=3 SV=1 CANONICAL=A0A3Q1M492-1" }, "locus": { "chromosome": "9", "start_pos": 73095936, "end_pos": 73074428, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119211.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119211.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092451.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092451.1" } ] } }, { "isoform_ac": "A0AAA9TIP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIP7/entry", "sequence": { "sequence": "MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSAVEPVEEYDYEDLKEFSSSLVNHQLSGIDQGKSIDSQSSQSESEIVPKVTKMTVSGKKQTMGFEVPRVTAEENGHSFHTPQKGHSSEDTSLVSSDALESASKSALPSHTIQASEEQSSTPTPVKKSGKLRQQIDIKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHLLYLLGDVNKRTMHKYEQESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETKTKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQVNWQQERFQEITGKLGHFLKQAGFKESDVAFIPTSGLSGENLITRSQSSELTKWYKGLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCVTGKIEAGYIQTGDRLLAMPPNETCTAKGITLHDEPVDWAAAGDHVSLTLVGMDIIKINVGCIFCVPKEPIKVCTRFRARILIFNIEIPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTKKKPKLLTKGQNALVELQTQRPVALELYKDFKELGRFMLRYSGSTIAAGVVTEIKD", "length": 621, "header": "tr|A0AAA9TIP7-1|A0A3Q1M492_BOVIN Computationally mapped isoform of HBS1-like protein OS=Bos taurus OX=9913 GN=HBS1L PE=3 SV=1 CANONICAL=A0A3Q1M492-1" }, "locus": { "chromosome": "9", "start_pos": 73095936, "end_pos": 73011562, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091922.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091922.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097012.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097012.1" } ] } }, { "isoform_ac": "A0AAA9TMF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMF0/entry", "sequence": { "sequence": "MARHRNVRGYNYDEARLYSCLDHMREVLGDAVPDDILIEAVLKNKFDVQKALSVVLEQDKVQNLKVRSEGAISTGKIAKGKESYYLPLKFQLIMFTALVLSLQTIWIAAANPLIFLAQ", "length": 118, "header": "tr|A0AAA9TMF0-1|A0A3Q1M492_BOVIN Computationally mapped isoform of HBS1-like protein OS=Bos taurus OX=9913 GN=HBS1L PE=3 SV=1 CANONICAL=A0A3Q1M492-1" }, "locus": { "chromosome": "9", "start_pos": 73095936, "end_pos": 73075771, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092322.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092322.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098163.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098163.1" } ] } }, { "isoform_ac": "A0AAA9TS84-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS84/entry", "sequence": { "sequence": "MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTARLYSCLDHMREVLGDAVPDDILIEAVLKNKFDVQKALSVVLEQDKVQNLKVRSEGAISTGKIAKGKSIDSQSSQSESEIVPKVTKMTVSGKKQTMGFEVPRVTAEENGHSFHTPQKGHSSEDTSLVSSDALESASKSALPSHTIQASEEQSSTPTPVKKSGKLRQQIDIKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHLLYLLGDVNKRTMHKYEQESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETKTKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQVNWQQERFQEITGKLGHFLKQAGFKESDVAFIPTSGLSGENLITRSQSSELTKWYKGLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCVTGKIEAGYIQTGDRLLAMPPNETCTAKGITLHDEPVDWAAAGDHVSLTLVGMDIIKINVGCIFCVPKEPIKVCTRFRARILIFNIEIPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTKKKPKLLTKGQNALVELQTQRPVALELYKDFKELGRFMLRYSGSTIAAGVVTEIKD", "length": 643, "header": "tr|A0AAA9TS84-1|A0A3Q1M492_BOVIN Computationally mapped isoform of HBS1-like protein OS=Bos taurus OX=9913 GN=HBS1L PE=3 SV=1 CANONICAL=A0A3Q1M492-1" }, "locus": { "chromosome": "9", "start_pos": 73095936, "end_pos": 73011562, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112910.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112910.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099340.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099340.1" } ] } }, { "isoform_ac": "F1N1V0-1", "url": "https://www.uniprot.org/uniprotkb/F1N1V0/entry", "sequence": { "sequence": "MARHRNVRGYNYDEDFEDDDLYGQSVEDDYCISPSTAAQFIYSRRDKPSAVEPVEEYDYEDLKEFSSSLVNHQLSGIDQARLYSCLDHMREVLGDAVPDDILIEAVLKNKFDVQKALSVVLEQDKVQNLKVRSEGAISTGKIAKGKSIDSQSSQSESEIVPKVTKMTVSGKKQTMGFEVPRVTAEENGHSFHTPQKGHSSEDTSLVSSDALESASKSALPSHTIQASEEQSSTPTPVKKSGKLRQQIDIKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHLLYLLGDVNKRTMHKYEQESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETKTKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQVNWQQERFQEITGKLGHFLKQAGFKESDVAFIPTSGLSGENLITRSQSSELTKWYKGLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCVTGKIEAGYIQTGDRLLAMPPNETCTAKVFTHFQESLCTMNLSTGRQQEIMLVLHWLEWISSKSMLAAYFVSPKNPLRFALVSEPESSSLILKFLSLKDFPCCYTTKPSVNPLLLKD", "length": 623, "header": "tr|F1N1V0-1|A0A3Q1M492_BOVIN Computationally mapped isoform of HBS1-like protein OS=Bos taurus OX=9913 GN=HBS1L PE=3 SV=2 CANONICAL=A0A3Q1M492-1" }, "locus": { "chromosome": "9", "start_pos": 73095936, "end_pos": 73016182, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026869.7", "url": "https://www.ensembl.org/id/ENSBTAT00000026869.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026869.6", "url": "https://www.ensembl.org/id/ENSBTAP00000026869.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-429958", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-429958", "resource": "Reactome", "description": "mRNA decay by 3' to 5' exoribonuclease" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "rescue of stalled ribosome", "id": "GO:0072344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072344", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M492", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M492" } ], "pmid": "" }, { "name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M492", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M492" } ], "pmid": "" }, { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M492", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M492" } ], "pmid": "" }, { "name": "nuclear-transcribed mRNA catabolic process, no-go decay", "id": "GO:0070966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070966", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M492", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M492" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M492", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M492" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M492", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M492" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M492", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M492" } ], "pmid": "" }, { "name": "translation elongation factor activity", "id": "GO:0003746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003746", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M492", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M492" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M492", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M492" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosolic ribosome", "id": "GO:0022626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022626", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M492", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M492" } ], "pmid": "" }, { "name": "Dom34-Hbs1 complex", "id": "GO:1990533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990533", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M492", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M492" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M492", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M492" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 525, "end_pos": 527, "annotation": "n_glycosylation_sequon" }, { "start_pos": 620, "end_pos": 622, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M4C0-1", "uniprot_ac": "A0A3Q1M4C0", "uniprot_id": "A0A3Q1M4C0_BOVIN", "mass": { "chemical_mass": 85724.0, "monoisotopic_mass": 85724.0 }, "refseq": { "ac": "XP_002685748", "name": "centrosomal protein of 85 kDa", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685748" }, "gene_names": [ { "name": "CEP85", "type": "recommended", "evidence": [ { "id": "A0A3Q1M4C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4C0" } ] }, { "name": "CEP85", "type": "synonym", "evidence": [ { "id": "XP_002685748", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685748" } ] } ], "protein_names": [ { "name": "Centrosomal protein 85", "type": "synonym", "evidence": [ { "id": "A0A3Q1M4C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4C0/entry#names_and_taxonomy" } ] }, { "name": "centrosomal protein of 85 kDa", "type": "synonym", "evidence": [ { "id": "XP_002685748", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685748" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4C0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4C0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEP85", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4C0", "locus": { "chromosome": "2", "start_pos": 126840740, "end_pos": 126876680, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009579", "url": "https://www.ensembl.org/id/ENSBTAG00000009579" } ] } } ], "crossref": [ { "id": "A0A3Q1M4C0", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M4C0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009579", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009579", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "517520", "url": "https://www.ncbi.nlm.nih.gov/gene/517520", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR040210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517520", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517520", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HFSETDW", "url": "https://omabrowser.org/oma/group/HFSETDW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M4C0", "url": "https://www.orthodb.org/?gene=A0A3Q1M4C0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N7M6", "url": "https://www.orthodb.org/?gene=F1N7M6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31075", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31075", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31075:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31075:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF24555", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24555", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002685748", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685748", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4C0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4C0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4C0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4C0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW76", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW76-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7M6", "url": "https://www.uniprot.org/uniprotkb/F1N7M6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7M6-1", "url": "https://www.uniprot.org/uniprotkb/F1N7M6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQDKYPSERISHATSPGSSVIQKGSSLGTEWQTPVISEAFRSRFSRCSSLADSGDTAIGTSCSDIAEDFCSSSSSPSFQPIKSHVTIPTAHVIPSTLGTSPSKPNSAAGSSTKLPLSGLAESVGMTRNGDLSSMKRSPGLSRDFMYLCGAAGENGVEQSWFPAVGHEREEEARKFDVPNMESTLNQSAMLETLYSDPHYRVYFHNPRTDTNKELYKGLPETKKAPGSGAVCERNGPHPGSSGVLPLGLQPAPGLSKPLPSQVWQPNPDPWHSRERSCELSTCRQQLELIRLQMEQMQLQNGAVCHHPAGFSPSLPTLDPAQWMSILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSKEKIELEKKLSASEVEVQLIRESLRVALQKHSEEGKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQERVTELESLLEETQAACREKEVQLESLRQREADFSSTQHSLQDEQCVEDASGDGPAQQGRGPQVEMESWQKECDSLRKIVERQQQKIDQLHSQVQSLEQEVAQEEGTSQALKEEAQRRETALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQSGSPSSSDTAQLAFELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSVHPGTQLDFQKPDVIRRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ", "length": 764, "header": "tr|A0A3Q1M4C0-1|A0A3Q1M4C0_BOVIN Isoform 1 of Centrosomal protein 85 OS=Bos taurus OX=9913 GN=CEP85 PE=4 SV=2 CANONICAL=A0A3Q1M4C0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4C0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4C0/entry", "sequence": { "sequence": "MQDKYPSERISHATSPGSSVIQKGSSLGTEWQTPVISEAFRSRFSRCSSLADSGDTAIGTSCSDIAEDFCSSSSSPSFQPIKSHVTIPTAHVIPSTLGTSPSKPNSAAGSSTKLPLSGLAESVGMTRNGDLSSMKRSPGLSRDFMYLCGAAGENGVEQSWFPAVGHEREEEARKFDVPNMESTLNQSAMLETLYSDPHYRVYFHNPRTDTNKELYKGLPETKKAPGSGAVCERNGPHPGSSGVLPLGLQPAPGLSKPLPSQVWQPNPDPWHSRERSCELSTCRQQLELIRLQMEQMQLQNGAVCHHPAGFSPSLPTLDPAQWMSILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSKEKIELEKKLSASEVEVQLIRESLRVALQKHSEEGKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQERVTELESLLEETQAACREKEVQLESLRQREADFSSTQHSLQDEQCVEDASGDGPAQQGRGPQVEMESWQKECDSLRKIVERQQQKIDQLHSQVQSLEQEVAQEEGTSQALKEEAQRRETALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQSGSPSSSDTAQLAFELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSVHPGTQLDFQKPDVIRRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ", "length": 764, "header": "tr|A0A3Q1M4C0-1|A0A3Q1M4C0_BOVIN Isoform 1 of Centrosomal protein 85 OS=Bos taurus OX=9913 GN=CEP85 PE=4 SV=2 CANONICAL=A0A3Q1M4C0-1" }, "locus": { "chromosome": "2", "start_pos": 126871105, "end_pos": 126841744, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069388.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069388.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068425.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068425.2" } ] } }, { "isoform_ac": "A0AAA9TW76-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW76/entry", "sequence": { "sequence": "MQDKYPSERISHATSPGSSVIQKGSSLGTEWQTPVISEAFRSRFSRCSSLADSGDTAIGTSCSDIAEDFCSSSSSPSFQPIKSHVTIPTAHVIPSTLGTSPSKPNSAAGSSTKLPLSGLAESVGMTRNGDLSSMKRSPGLSRDFMYLCGAAGENGVEQSWFPAVGHEREEEARKFDVPNMESTLNQSAMLETLYSDPHYRVYFHNPRTDTNKELYKGLPETKKAPGSGAVCERNGPHPGSSGVLPLGLQPAPGLSKPLPSQVWQPNPDPWHSRERSCELSTCRQQLELIRLQMEQMQLQNGAVCHHPAGFSPSLPTLDPAQWMSILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSKEKIELEKKLSASEVEVQLIRESLRVALQKHSEEGKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQERVTELESLLEETQAACREKEVQLESLRQREADFSSTQHSLQDEQCVEDASGDGPAQQGRGPQVEMESWQKECDSLRKSLEQEVAQEEGTSQALKEEAQRRETALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQSGSPSSSDTAQLAFELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSVHPGTQLDFQKPDVIRRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ", "length": 747, "header": "tr|A0AAA9TW76-1|A0A3Q1M4C0_BOVIN Computationally mapped isoform of Centrosomal protein 85 OS=Bos taurus OX=9913 GN=CEP85 PE=4 SV=1 CANONICAL=A0A3Q1M4C0-1" }, "locus": { "chromosome": "2", "start_pos": 126871105, "end_pos": 126841744, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106798.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106798.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102867.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102867.1" } ] } }, { "isoform_ac": "F1N7M6-1", "url": "https://www.uniprot.org/uniprotkb/F1N7M6/entry", "sequence": { "sequence": "AMQDKYPSERISHATSPGSSVIQKGSSLGTEWQTPVISEAFRSRFSRCSSLADSGDTAIGTSCSDIAEDFCSSSSSPSFQPIKSHVTIPTAHVIPSTLGTSPSKPNSAAGSSTKLPLSGLAESVGMTRNGDLSSMKRSPGLSRDFMYLCGAAGENGVEQSWFPAVGHEREEEARKFDVPNMESTLNQSAMLETLYSDPHYRVYFHNPRTDTNKELYKGLPETKKAPGSGAVCERNGPHPGSSGVLPLGLQPAPGLSKPLPSQVWQPNPDPWHSRERSCELSTCRQQLELIRLQMEQMQLQNGAVCHHPAGFSPSLPTLDPAQWMSILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSKEKIELEKKLSASEVEVQLIRESLRVALQKHSEEGKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQERVTELESLLEETQAACREKEVQLESLRQREADFSSTQHSLQDEQCVEDASGDGPEVEMESWQKECDSLRKIVERQQQKIDQLHSQVQSLEQEVAQEEGTSQALKEEAQRRETALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQSGSPSSSDTAQLAFELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAVHPGTQLDFQKPDVIRRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ", "length": 759, "header": "tr|F1N7M6-1|A0A3Q1M4C0_BOVIN Computationally mapped isoform of Centrosomal protein 85 OS=Bos taurus OX=9913 GN=CEP85 PE=4 SV=3 CANONICAL=A0A3Q1M4C0-1" }, "locus": { "chromosome": "2", "start_pos": 126871108, "end_pos": 126841744, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012597.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012597.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012597.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012597.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517520", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517520", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JUV7-1", "protein_name": "Centrosomal protein 85", "gene_name": "Cep85", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAMQEKYPSDRSPHTASPGSNVIQKGSSLGTEWQTPVISEAFRSRFSRCSSIADSGDTAIGTSCSDIAEDFCSSSGSPSFQPIKSHITIPTAHVMPSTLGASPAKPSPTPSGPSSAKLPLSGLTEGVGMTRNGDFGAVKRSPGLSRDFMYLPSAAGENGIQQSWFPAVGHEREGEMRKFDVSSMESTLNQPAMLETLYSDPHYRAHFPTPRPDTNKDAYKVLPESKKAPGSGAVFERNGPHASNSGVLPLGLQPAPGLSKSLSSQVWQPSPDPWHPGEQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFTPSLPTLEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSKEKMELEKKLSASEVEIQLIRESLKVTLQKHSEEGKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQTEQLKDAELKNTELQGRVAELETMLEDTQAACREKEVQLESLRQREAQFSSARHSFQDKQSLEEASGESLKVEMESQQKECDSLRKIVERQQLKLEQLHSQVQSQKQELAQEEGISQALREEAQRRETALQQMRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSSSGSPDAAQLAYELHQELASCLQDLQAVCSIVTQRAQGHSPNLSLLLGIHSTPHPGTQLDLQKPDVIRRKLEEVQQLRHDIEDLRTSLSDRYAQDMGENCATQ", "length": 763 }, "evidence": [ { "id": "A0A3Q1M4C0", "url": "https://omabrowser.org/oma/group/A0A3Q1M4C0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8C2M334-1", "protein_name": "Centrosomal protein of 85 kDa isoform X1", "gene_name": "Cep85", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAMQEKYPNDRSSHATSPGSNVIQKGSSLGTEWQTPVISEAFRSRFSRCSSIADSGDTAIGTSCSDIAEDFCSSSGSPSFQPIKSHITIPTAHVMPSTLGASPAKPNSTPSGPSSSKLPLSGLAEGVGMTRNGDFGAVKRSPGLSRDFMYLPSAPGENGIQQSWFPAVGHEREGEMRKFDIPSMESTLNQPAMVETLYSDPHYRVHFPTPRSDANKDVYKVLPESKKAPGSGAVFERNGPHASNSGVLPLGLQPAPGLSKSLSSQVWQPSPDPWHPGEQSCELSTCRQQLELIRLQMEQMQLQNGAVCHHPAAFAPLLPTLEPAQWLSILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSKEKMELEKKLSASEVEIQLIRESLKVTLQKHSEEGKKQEERVKGRDKHINNLKKKCQKEAEQNREKQQRIETLERYLADLPTLEDHQKQTEQLKDAELKNTELQERVAELETLVEDTQATCREKEVQLESLRQKEAEFFSARHSLQDKQSVEDTNGEGLEVETESQQKECDSLRKIVERQQLKIEQLHSQVQSLKQELAQEEGISQALKEEAQRRETALQQMRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSTSSPDTAQLAYELHQELAICLQDLQAVCSIVTQRAQGHNPNLSLLLGIHSTQHPGTQLDLQKPDVVRRKLEEVQQLRHDIEDLRTSLSDRYAQDMGENCATQ", "length": 762 }, "evidence": [ { "id": "A0A3Q1M4C0", "url": "https://omabrowser.org/oma/group/A0A3Q1M4C0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0YJI0-1", "protein_name": "Centrosomal protein 85", "gene_name": "CEP85", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAALEEHPDLRLQHSNPSDPSAAQKSHFSETDWKTPMLSVKFQSRTSRCSSAADSGDVGIGTSCSDSTEDFCSSSNGSSFQPIKTQVTIPTAHVMPSTLGASPSKLCSAGEQSCLQSTSKTAVPGSASEHAGLMRNGDFNAGKSSQLPHRDLLRLYGTSGENGFEQSWRPVSDHVRTEDTWKFDTPAIERTLNQSLFLDSLCADPLQRFQKFSSSSGAAEAGGDHYKVLPEIKQVAGANGACESQDRTWPGGSRLMPTGLQTNSFFPKPITSPSRAWMQETCTLHPHERVCELSAWKQQLDNVRLQIEQMQLQNGSACHHPSMYSPSLPTPDPAQWINILNSHENLLKEKELLIDRQRQHISQLEQKVRESELQVHSALLGCPAPCGDVYMLRMQELQRENTFLRAQFTEKTESLSKEKIELERKLAAAEVDAKLIRETLKENMQKYAEDLKKQEERVKGRDKHINNLKKKCQKESEQNRERQQRIETLERYLADLPTLEDHQKQSQKLKESELKSTTLQETVLALETELGDVRAAFREQEMQLETQKHKELELLSTVRSLQDKVQQCVKNAERGPPVQDGEKQKIENDSLKKECDCLRKIVEKQQKKMEQLSLQVKNLEEQVAQEEGTSQALKEEALRRENVLQQLRTAVKELSVQNQDLIEKNLTIQERLRQAELTAQPLPAETARLAQELHCELASCLQDLQSVYSIVTQRAQGKDPNLSLLLGIRSVQYSAKEKDDLLSPDVLAKKLVEVKQLHKEVEDLRTAISDRYAQDMGDNCITQ", "length": 783 }, "evidence": [ { "id": "A0A3Q1M4C0", "url": "https://omabrowser.org/oma/group/A0A3Q1M4C0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6P2H3-1", "protein_name": "Centrosomal protein of 85 kDa", "gene_name": "CEP85", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAMQEKYPTEGISHVTSPSSDVIQKGSSLGTEWQTPVISEPFRSRFSRCSSVADSGDTAIGTSCSDIAEDFCSSSGSPPFQPIKSHVTIPTAHVMPSTLGTSPAKPNSTPVGPSSSKLPLSGLAESVGMTRNGDLGAMKHSPGLSRDLMYFSGATGENGIEQSWFPAVGHERQEEARKFDIPSMESTLNQSAMMETLYSDPHHRVRFHNPRTSTSKELYRVLPEAKKAPGSGAVFERNGPHSNSSGVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ", "length": 762 }, "evidence": [ { "id": "A0A3Q1M4C0", "url": 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"Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377748" }, "gene_names": [ { "name": "OR1J33", "type": "recommended", "evidence": [ { "id": "A0A3Q1M4L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L8" } ] }, { "name": "OR1J33", "type": "synonym", "evidence": [ { "id": "NP_001377748", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377748" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "A0A3Q1M4L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L8/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 1 subfamily J member 33", "type": "synonym", "evidence": [ { "id": "NP_001377748", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377748" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377748" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4L8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L8#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4L8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR1J33", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L8", "locus": { "chromosome": "11", "start_pos": 93516847, "end_pos": 93515909, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000064300", "url": "https://www.ensembl.org/id/ENSBTAG00000064300" } ] } } ], "crossref": [ { "id": "A0A3Q1M4L8", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M4L8", "database": "AlphaFoldDB", "categories": [] }, { "id": "119646079", "url": "https://www.ncbi.nlm.nih.gov/gene/119646079", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:119646079", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:119646079", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377748", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4L8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4L8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRKENQSSVSEFLLLGLPIRPEQQGVFFALFLGVYLTTVLGNLLIILLIRLDPHLHTAMYFFLSHLAFSDISLSTITVPKMLMNMHTQQQSIPYVECISQMYFFILFGCFDNFLLAVMAYDRYVAICQPLHYTTVMRQELCISLVAVSWFFCCIHALLHTLLLVQLSFCAENTIPNFFCDLPSLLKMSCSDISINELVIFTEGGMLFILPLSIILGSYVHIGTIILRVPSIKRLFKAFSTCGSHLFVVSLYYGTLAGAYFFSLLWDSNDKDVIASVMYTVVTPMLNPFIYSLRNRDIKQALEIFVFRGNFFR", "length": 312, "header": "tr|A0A3Q1M4L8-1|A0A3Q1M4L8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR1J33 PE=3 SV=2 CANONICAL=A0A3Q1M4L8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4L8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L8/entry", "sequence": { "sequence": "MRKENQSSVSEFLLLGLPIRPEQQGVFFALFLGVYLTTVLGNLLIILLIRLDPHLHTAMYFFLSHLAFSDISLSTITVPKMLMNMHTQQQSIPYVECISQMYFFILFGCFDNFLLAVMAYDRYVAICQPLHYTTVMRQELCISLVAVSWFFCCIHALLHTLLLVQLSFCAENTIPNFFCDLPSLLKMSCSDISINELVIFTEGGMLFILPLSIILGSYVHIGTIILRVPSIKRLFKAFSTCGSHLFVVSLYYGTLAGAYFFSLLWDSNDKDVIASVMYTVVTPMLNPFIYSLRNRDIKQALEIFVFRGNFFR", "length": 312, "header": "tr|A0A3Q1M4L8-1|A0A3Q1M4L8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR1J33 PE=3 SV=2 CANONICAL=A0A3Q1M4L8-1" }, "locus": { "chromosome": "11", "start_pos": 93516844, "end_pos": 93515909, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077822.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077822.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065164.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065164.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:119646079", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:119646079", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4L8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4L8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4L8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4L8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M4L8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 312, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M4L8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M4L8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M4L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4L8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", 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"https://www.uniprot.org/uniprotkb/A0A3Q1M4P9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM83H", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P9", "locus": { "chromosome": "14", "start_pos": 1038705, "end_pos": 1025885, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038682", "url": "https://www.ensembl.org/id/ENSBTAG00000038682" } ] } } ], "crossref": [ { "id": "ENSBTAG00000038682", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038682", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09188", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09188", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524974", "url": "https://www.ncbi.nlm.nih.gov/gene/524974", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012461", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012461", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050944", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050944", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524974", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524974", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GCHGEDT", "url": "https://omabrowser.org/oma/group/GCHGEDT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M4P9", "url": "https://www.orthodb.org/?gene=A0A3Q1M4P9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1B8J6", "url": "https://www.orthodb.org/?gene=E1B8J6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16181", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16181", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16181:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16181:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07894", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07894", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M4P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4P9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAU8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8J6", "url": "https://www.uniprot.org/uniprotkb/E1B8J6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B8J6-1", "url": "https://www.uniprot.org/uniprotkb/E1B8J6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGKRSRARKPRPRRAGRAQKATGQQGPEARPPPPAPGCLGDEAGVAPTGHVTSSKLAPQGHPKVARPERPQEAERPEQAAAVGSELVLVPAADMEGYGVGGLVPGLGPELLRLHEVELCLAQEQLLLEDRRQQAQLHMRLWQEEQLWLQQLQEQQAWVRVEGLELALALEQLRSEGLEALQTQDPVPGPNMARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALAEGGPEAYSRFLASEGAPAFLCPEELEHVSRHLRPPQHVAPEPPDGSPPNLDFDGSSGTYWPVNSDQAVPELDLGWPLTFGFQGTEVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYILLDEMNAQHFLDMADKCRVNLHHVDFLRVRTVAGPTYYCRTGKSFKGHVKEKFLLVDCAVVMSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAGALARMDTYALAPYAGAGPLMGSQMPGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRREESSRMPGGALEPHTGLRPLSRRLDAEAGPGGELSGPRGFFQARHLEMDAFKRYSYAAADGAGAVENLAAARQVSRQTFLSHGDDLRFQTSHFHRDQLYQQHYQWDPQLAPTRPQGLFEKLRAGRPGFPDHDEFMLGTGPRFPELGLDGHQRLDYVPSSASREVRHGSDPAFGPGPRGLEPGGAPRPNLGQRFSCQAMTRLGPEMAPEPEPEHRGGPEGRAGLRHWRLTSYLSGCHSEDAGDEGLPTPMETEAYDDDVLVSGGRATAGDLLPSAFRVPAPFPGKGPAPGSGSGGGDGPEREGLEEVGLAKQDSFRSRLNPLIQRSSRLRSSLIFSASQGEGTGGPTGASTEKVQLLHKEQTVSEMLGPGNEAVRSAASTKVAELLEKYKGPSRDPGGVGTAVTAASHSKAVVSQAWREEVSAPGGGSGSERRSLESCLLDLRESFAQQLHQEAERQPGAATLASTQLLDTLGRGSSGTDRLPSRFLSTQGHSTSPQGRDSPPPEGPGGQQSEPKGSPTLAYPERKGSPTPGFPTRRGSPTAGFTEQKGSPTSAYPERRGSPVPPVPERRGSPVPPVPERRGSLTLPFSGESPKAGPTEEAVGGPMEVLRKGSARLRQLMSPKGERRADDEGSFPTPQENGQPESPQWPSLVRVDSTEAAAEERGPRARVASATANALYSSNLRDDTKAILEQISAHGQKHRGVPAPGPTPAHSSPELGHSPVAGGLAPDMSDKDKCSAIFRSDSLGTQGRLSRTLPAGAEERDRLLRRMESMRKEKRVYSRFEVFCKKEEPGALGAAEGPAEEDARDSKVGKFMPKILGTFKSKK", "length": 1372, "header": "tr|A0A3Q1M4P9-1|A0A3Q1M4P9_BOVIN Isoform 1 of Family with sequence similarity 83 member H OS=Bos taurus OX=9913 GN=FAM83H PE=3 SV=1 CANONICAL=A0A3Q1M4P9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4P9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P9/entry", "sequence": { "sequence": "MSGKRSRARKPRPRRAGRAQKATGQQGPEARPPPPAPGCLGDEAGVAPTGHVTSSKLAPQGHPKVARPERPQEAERPEQAAAVGSELVLVPAADMEGYGVGGLVPGLGPELLRLHEVELCLAQEQLLLEDRRQQAQLHMRLWQEEQLWLQQLQEQQAWVRVEGLELALALEQLRSEGLEALQTQDPVPGPNMARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALAEGGPEAYSRFLASEGAPAFLCPEELEHVSRHLRPPQHVAPEPPDGSPPNLDFDGSSGTYWPVNSDQAVPELDLGWPLTFGFQGTEVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYILLDEMNAQHFLDMADKCRVNLHHVDFLRVRTVAGPTYYCRTGKSFKGHVKEKFLLVDCAVVMSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAGALARMDTYALAPYAGAGPLMGSQMPGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRREESSRMPGGALEPHTGLRPLSRRLDAEAGPGGELSGPRGFFQARHLEMDAFKRYSYAAADGAGAVENLAAARQVSRQTFLSHGDDLRFQTSHFHRDQLYQQHYQWDPQLAPTRPQGLFEKLRAGRPGFPDHDEFMLGTGPRFPELGLDGHQRLDYVPSSASREVRHGSDPAFGPGPRGLEPGGAPRPNLGQRFSCQAMTRLGPEMAPEPEPEHRGGPEGRAGLRHWRLTSYLSGCHSEDAGDEGLPTPMETEAYDDDVLVSGGRATAGDLLPSAFRVPAPFPGKGPAPGSGSGGGDGPEREGLEEVGLAKQDSFRSRLNPLIQRSSRLRSSLIFSASQGEGTGGPTGASTEKVQLLHKEQTVSEMLGPGNEAVRSAASTKVAELLEKYKGPSRDPGGVGTAVTAASHSKAVVSQAWREEVSAPGGGSGSERRSLESCLLDLRESFAQQLHQEAERQPGAATLASTQLLDTLGRGSSGTDRLPSRFLSTQGHSTSPQGRDSPPPEGPGGQQSEPKGSPTLAYPERKGSPTPGFPTRRGSPTAGFTEQKGSPTSAYPERRGSPVPPVPERRGSPVPPVPERRGSLTLPFSGESPKAGPTEEAVGGPMEVLRKGSARLRQLMSPKGERRADDEGSFPTPQENGQPESPQWPSLVRVDSTEAAAEERGPRARVASATANALYSSNLRDDTKAILEQISAHGQKHRGVPAPGPTPAHSSPELGHSPVAGGLAPDMSDKDKCSAIFRSDSLGTQGRLSRTLPAGAEERDRLLRRMESMRKEKRVYSRFEVFCKKEEPGALGAAEGPAEEDARDSKVGKFMPKILGTFKSKK", "length": 1372, "header": "tr|A0A3Q1M4P9-1|A0A3Q1M4P9_BOVIN Isoform 1 of Family with sequence similarity 83 member H OS=Bos taurus OX=9913 GN=FAM83H PE=3 SV=1 CANONICAL=A0A3Q1M4P9-1" }, "locus": { "chromosome": "14", "start_pos": 1037701, "end_pos": 1025894, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086728.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086728.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068570.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068570.1" } ] } }, { "isoform_ac": "A0AAA9TAU8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAU8/entry", "sequence": { "sequence": "MSILVPGPNMARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALAEGGPEAYSRFLASEGAPAFLCPEELEHVSRHLRPPQHVAPEPPDGSPPNLDFDGSSGTYWPVNSDQAVPELDLGWPLTFGFQGTEVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYILLDEMNAQHFLDMADKCRVNLHHVDFLRVRTVAGPTYYCRTGKSFKGHVKEKFLLVDCAVVMSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAGALARMDTYALAPYAGAGPLMGSQMPGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRREESSRMPGGALEPHTGLRPLSRRLDAEAGPGGELSGPRGFFQARHLEMDAFKRYSYAAADGAGAVENLAAARQVSRQTFLSHGDDLRFQTSHFHRDQLYQQHYQWDPQLAPTRPQGLFEKLRAGRPGFPDHDEFMLGTGPRFPELGLDGHQRLDYVPSSASREVRHGSDPAFGPGPRGLEPGGAPRPNLGQRFSCQAMTRLGPEMAPEPEPEHRGGPEGRAGLRHWRLTSYLSGCHSEDAGDEGLPTPMETEAYDDDVLVSGGRATAGDLLPSAFRVPAPFPGKGPAPGSGSGGGDGPEREGLEEVGLAKQDSFRSRLNPLIQRSSRLRSSLIFSASQGEGTGGPTGASTEKVQLLHKEQTVSEMLGPGNEAVRSAASTKVAELLEKYKGPSRDPGGVGTAVTAASHSKAVVSQAWREEVSAPGGGSGSERRSLESCLLDLRESFAQQLHQEAERQPGAATLASTQLLDTLGRGSSGTDRLPSRFLSTQGHSTSPQGRDSPPPEGPGGQQSEPKGSPTLAYPERKGSPTPGFPTRRGSPTAGFTEQKGSPTSAYPERRGSPVPPVPERRGSPVPPVPERRGSLTLPFSGESPKAGPTEEAVGGPMEVLRKGSARLRQLMSPKGERRADDEGSFPTPQENGQPESPQWPSLVRVDSTEAAAEERGPRARVASATANALYSSNLRDDTKAILEQISAHGQKHRGVPAPGPTPAHSSPELGHSPVAGGLAPDMSDKDKCSAIFRSDSLGTQGRLSRTLPAGAEERDRLLRRMESMRKEKRVYSRFEVFCKKEEPGALGAAEGPAEEDARDSKVGKFMPKILGTFKSKK", "length": 1190, "header": "tr|A0AAA9TAU8-1|A0A3Q1M4P9_BOVIN Computationally mapped isoform of Family with sequence similarity 83 member H OS=Bos taurus OX=9913 GN=FAM83H PE=3 SV=2 CANONICAL=A0A3Q1M4P9-1" }, "locus": { "chromosome": "14", "start_pos": 1037701, "end_pos": 1031571, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111420.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111420.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093772.2", "url": "https://www.ensembl.org/id/ENSBTAP00000093772.2" } ] } }, { "isoform_ac": "E1B8J6-1", "url": "https://www.uniprot.org/uniprotkb/E1B8J6/entry", "sequence": { "sequence": "MARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALAEGGPEAYSRFLASEGAPAFLCPEELEHVSRHLRPPQHVAPEPPDGSPPNLDFDGSSGTYWPVNSDQAVPELDLGWPLTFGFQGTEVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYILLDEMNAQHFLDMADKCRVNLHHVDFLRVRTVAGPTYYCRTGKSFKGHVKEKFLLVDCAVVMSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAGALARMDTYALAPYAGAGPLMGSQMPGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRREESSRMPGGALEPHTGLRPLSRRLDAEAGPGGELSGPRGFFQARHLEMDAFKRYSYAAADGAGAVENLAAARQVSRQTFLSHGDDLRFQTSHFHRDQLYQQHYQWDPQLAPTRPQGLFEKLRAGRPGFPDHDEFMLGTGPRFPELGLDGHQRLDYVPSSASREVRHGSDPAFGPGPRGLEPGGAPRPNLGQRFSCQAMTRLGPEMAPEPEPEHRGGPEGRAGLRHWRLTSYLSGCHSEDAGDEGLPTPMETEAYDDDVLVSGGRATAGDLLPSAFRVPAPFPGKGPAPGSGSGGGDGPEREGLEEVGLAKQDSFRSRLNPLIQRSSRLRSSLIFSASQGEGTGGPTGASTEKVQLLHKEQTVSEMLGPGNEAVRSAASTKVAELLEKYKGPSRDPGGVGTAVTAASHSKAVVSQAWREEVSAPGGGSGSERRSLESCLLDLRESFAQQLHQEAERQPGAATLASTQLLDTLGRGSSGTDRLPSRFLSTQGHSTSPQGRDSPPPEGPGGQQSEPKGSPTLAYPERKGSPTPGFPTRRGSPTAGFTEQKGSPTSAYPERRGSPVPPVPERRGSPVPPVPERRGSLTLPFSGESPKAGPTEEAVGGPMEVLRKGSARLRQLMSPKGERRADDEGSFPTPQENGQPESPQWPSLVRVDSTEAAAEERGPRARVASATANALYSSNLRDDTKAILEQISAHGQKHRGVPAPGPTPAHSSPELGHSPVAGGLAPDMSDKDKCSAIFRSDSLGTQGRLSRTLPAGAEERDRLLRRMESMRKEKRVYSRFEVFCKKEEPGALGAAEGPAEEDARDSKVGKFMPKILGTFKSKK", "length": 1181, "header": "tr|E1B8J6-1|A0A3Q1M4P9_BOVIN Computationally mapped isoform of Family with sequence similarity 83 member H OS=Bos taurus OX=9913 GN=FAM83H PE=3 SV=3 CANONICAL=A0A3Q1M4P9-1" }, "locus": { "chromosome": "14", "start_pos": 1037701, "end_pos": 1033034, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019225.6", "url": "https://www.ensembl.org/id/ENSBTAT00000019225.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019225.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019225.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1076, "start_aa": "Thr", "end_pos": 1076, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1076", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1144, "start_aa": "Thr", "end_pos": 1144, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1144", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1182, "start_aa": "Thr", "end_pos": 1182, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1182", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1256, "start_aa": "Thr", "end_pos": 1256, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1256", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 893, "start_aa": "Thr", "end_pos": 893, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr893", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 950, "start_aa": "Thr", "end_pos": 950, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr950", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:524974", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524974", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K8J4-1", "protein_name": "Family with sequence similarity 83, member H", "gene_name": "Fam83h", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQAPGEQTSGERGTGSRAMSGKRARARKPRGKRVGRAQRAAGRQGPQAEPPPPNTGGPQDQVGVAPTEHVTSIQPAPQGHSRATRPEQLQAAPRPVQAAALESELVLAPEHMEGYGAGAPVPALGPELLRLHEVQLCLAQEQLLLEDRRRQVQLQMQLWQEEQLWLQQLQEEQLWLQQLQEEQAWVHMEGLQLAVALEQLRSEGVEALQTQGQAPGPNMARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALTEGGQEAYNRFLASEGAPDFLCPEELEHVSRHLQPPQYVSREPPEGAPPDVDMDGSSGTYWPVDSDQAVPELDLGWPLTFGFQGTEVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYILLDEMNAQHFLDMADKCRVNLHHVDFLRVRTVAGPTYYCRTGKSFKGHLKEKFLLVDCAVVMSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAGALARMDAYALTPYSGAGPLVGVPGVGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRRDELQRMPGGALEPHTGLRPLARPGEAGPLGELPGPRGFFQSRHLEMDAFKRHSYTAADGAGAVENFAAARQVSRQTFLSHGDDFRFQTSHFQRDQLYQQHYQWDPQFAPARPQGLFEKLRAGRPGFADPDDFALGAGHRFPELGADVHQRLEYVPSSASREVRHGSDPAFGPSPRGLEPSGASRPNLGQRFPCQATLRQGLDTATEAEPERRGGPEGRAGLRHWRLASYLSGCHGDGGEEGLPMEAEACEDEVLAPGGRDLLPSTFRTPAPFPAKGPKPGSGSGGGDSSEREGPEETGLIKQDSFRSRLNPLIQRSSRLRSSLIFASQAEGTAGTTAATTEKVQLMHKEQTISETLGPSGEAVRSSASAKVAELLEKYKGPARDPGGAGGAITASSHSKAVVSQAWREEVVAPGGAGAERRSLESCLLDLRDSFAQQLHQEAERHPGAASLTAAQLLDTLGGTDRLPSRFLSAQGRSLSPQGRDSPPPEGLGTHQLPYSEPKGSPTPAYPERKGSPTPAYPERKGSPTPAYPERKGSPTPAYPERKGSPTPAYPERKGSPTSGFPNRRGSPTTGLMEQKGSPTSTYPDRRSSPVPPVPERRGSPVPPVPERRGSLTFAGESSKTGPTEEVSGGPMEVLRKGSLRLRQLLSPKSERRGEDEVSFPAPQENGQPESPRRPSLSRGDSTEAAAEERGSRVRLASATANALYSSNLRDDTKAILEQISAHGQKHRAVPAPGPAHNSSDVGRPTTAGDLAPDMSDKDKCSAIFRSDSLGTQGRLSRTLPASAEERDRLLRRMESMRKEKRVYSRFEVFCKKEDAGSSAAGDNLADEDTRDSKMGKFVPKILGTFKSKK", "length": 1428 }, "evidence": [ { "id": "A0A3Q1M4P9", "url": "https://omabrowser.org/oma/group/A0A3Q1M4P9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A1D5PUM9-1", "protein_name": "Family with sequence similarity 83 member H", "gene_name": "FAM83H", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARRSQSSSQGDNPLDPNYLPPHYKEYYRLALDILTEEGKESYERFLAEEAAPDFLCNSEVDHILQNLQKPQYANQEGGTDTAGDNDVDGSSGTYWPMNSDLAVPELDLGWPMVFGFRGTEVTTLVQPPPPDNPSIKEEARRMIRAAQQVVAIVMDVFTDVDLLFEVLDAAARRVPVYILLDEMNSQLFLDTAAKCRVNLNYVEFLRVRTVSGPTYYCRTGMSFKGHVKEKFLLVDCMVVLSGNYSFMWSFEKIHRSIAHIFQGELVASFDEEFRILFAQSEPLVPPANVLAKAENPFAMTPFGNNMPFFPKKSPLMFQRDDNLFPSFMDRVDPDRFFLSNFRRDDMLRHTVEGSAMRMYKKVEMENAQMDPVRGFLRSKQLELDAFKRHSFAEGTFENFASSKQYARQMFMNNMDEFKIQSSHFQKDQFYQYQFEHPHLSGRPQGFFDRIRGGRPGFNELEEGGPLPYGEGPRYHELESGFPQEGFPLRLDYVPSNSSREVRHGSDQLNPAGNGPMGMMLRRQNIGQKFICQTSPTQKQSLEQRLFLQDKDEDQDQDKSTQENRTGLRNWRISSYLSAYQSEPEEGLPMPMESEAYNDVLGDPLTKHPTDLIPAFKSPISFNSKSLGVENAKEFADPERGGEEAPMMKQDAFRTRINPLIQRSSRLRSSLIFNAAKLDQPNTTVEKVQMIHKEQVSSELTKDNETIKTAASSKVAELLEKYKAVGKDAERATVTHTKAVSSFLQEESQNAEKKCTKSVQYKILESRVLESKDSCSTYKMHGETDRTFGMSSSTPQLIDALSKDPLAHLGTKVDKLSSRFYPMENKPALPEKESLIFVGDTQKLALPEKKERVTFKEDAEKLVSAELKKPQVRTGATSAIENLSKGQGSDSSLNRSEEECSKQEQNTMEFLRKGSLRLKQFLNPKGEKKLEEEPNSEIGKSDKQPMGLKRSSMGDCQEMLGEEEKNHKFATLLPPKSSQPTQGRFPSSTANILYSSNLRDDTKVILEQISANSQKNRAELAKQLPSTSNPDLSKSTMSLERKTEKEKSCNIHRSESFGSQKRNLQRQPSEDRDTLLKKMENMRKEKRVYSRFEVFCKKDEHTSQSEEEYDTDAKDKKMGKFMPKILGTFKTKK", "length": 1133 }, "evidence": [ { "id": "A0A3Q1M4P9", "url": "https://omabrowser.org/oma/group/A0A3Q1M4P9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HWJ9-1", "protein_name": "Protein FAM83H", "gene_name": "Fam83h", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALTEGGPEAYSRFLASEGAPDFLCPEELEHVSRHLQPPQYVAREPPEGSPPDVDMDGSSGTYWPVNSDQAVPELDLGWPLTFGFQGTEVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYILLDEMNAQHFLDMADKCRVNLHHVDFLRVRTVAGPTYYCRTGKSFKGHLKEKFLLVDCAVVMSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAGMLARMDAYALAPYSGAGPLVGVPGVGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRREELQRMPGGALEPHAGLRPLARPAEAGPMGELAGPRGFFQARHLEMDAFKRHSYTAADGAGAVENFAAARQVSRQTFLSHGDDFRFQTSHFQRDQLYQQHYQWDPQFAPTRPQGLFEKLRAGRPGFADPDDLALGAGSRFPELGGDVHQRLEYVPSSASREVRHGSDPAFGTGPRGVEPNGALRPNLGQRFPCQASLRQGLDTTTEVEPERRGGPEGRAGLRHWRLASYLSGCHGDGGEEGLPMETEAYDDEVLTPGGRDLLPSAFRNPVPFPAKGPKPGSGSGGGDSSEREGTEETNLTKQDSFRSRLNPLIQRSSRLRSSLIFASQAEGASGTTATTTEKVQLLHKEQTVSETLGPSGEAVRSSASAKVAELLEKYKGPARDPGGAGGPITASHHSKAVVAQSWREEVVAPGGAGTERRSLESCLLDLRDSFAQQLHQEAERHPGAASLTAAQLLDTLGSTDRLPSRLLSTQGRSLSPQGRDSPPLEGPGTHQLPYSEPKGSPTPNYPEHKGSPTSGFPSRRGSPTTGLTEQKGSPTSAYPDRRGSPVPPVPERRGSPVPPVPERRGSLTFAGEPSKTGPTEEVTSGPMEALRKGSLRLRQFLSPKSERRGEDEGSFPAPQENGQPESPRRPSLGRGDSTEAAADERSPKVRLASATANALYSSNLRDDTKAILEQISAHGQKHRGVPAPGPSHSSPELGRPTTAGDLSPDMSDKDKCSAIFRSDSLGTQGRLSRTLPASAEERDRLLRRMESMRKEKRVYSRFEVFCKKEEAGSTGAGDNLADEDTRDSKMGKFVPKILGTFKSKK", "length": 1165 }, "evidence": [ { "id": "A0A3Q1M4P9", "url": "https://omabrowser.org/oma/group/A0A3Q1M4P9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q148V8-1", "protein_name": "Protein FAM83H", "gene_name": "Fam83h", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALTEGGPEAYNRFLASEGAPDFLCPEELEHVSRHLQPPQYVAREPPEGTPSDVDMDGSSGTYWPVNSDQAVPELDLGWPLTFGFQGTEVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYILLDEMNAQHFLDMADKCRVNLHHVDFLRVRTVAGPTYYCRTGKSFKGHLKEKFLLVDCAVVMSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAGALARMDAYALAPYSGAGPLVGVPGVGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRREELQRMPGGALEPHTGLRPLARPTEAGPFGELAGPRGFFQSRHLEMDAFKRHSYATPDGAGAVENFAAARQVSRQTFLSHGDDFRFQTSHFQRDQLYQQHYQWDPQFAPARPQGLFEKLRAGRPGFADPDDFALGAGHRFPELGADVHQRLEYVPSSASREVRHGSDPAFGPSPRGLEPSGASRPNLGQRFPCQATLRQGLDTASEAEPERRGGPEGRAGLRHWRLASYLSGCHGDGGEEGLPMEAEACEDEVLAPGGRDLLPSAFRTPAAFPAKGPKPGSGSGGGDSSEREGPEETSLAKQDSFRSRLNPLIQRSSRLRSSLIFASQAEGAVGTAAATTEKVQLMHKEQTVSETLGPSGEAVRSSASAKVAELLEKYKGPARDPGGAGGAVTSSSHSKAVVSQAWREEVVAPGGAGTERRSLESCLLDLRDSFAQQLHQEAERHPGAASLTAAQLLDTLGGTDRLPSRFLSAQGRSLSPQGRDSPPPEGLGTHQLPYSEPKGNPTPAYPERKGSPTPAYPERKGSPTPAYPERKGSPTPAYPERKGSPTQAYPERKGSPTSGFPNRRGSPTTGLMEQKGSPTSTYPDRRGSPVPPVPERRGSPVPPVPERRGSLTFAGESSKTGPTEEVSSGPMEVLRKGSLRLRQLLSPKNERRGEDEGSFPTPQENGQPESPRRPSLSRGDSTEAAAEERGSRVRLASATANALYSSNLRDDTKAILEQISAHGQKHRGVPAPGPAHSSPDVGRPTTAGDLAPDMSDKDKCSAIFRSDSLGTQGRLSRTLPGSAEERDRLLRRMESMRKEKRVYSRFEVFCKKDEAGSSGAGDNLADEDTRDSKMGKFVPKILGTFKSKK", "length": 1209 }, "evidence": [ { "id": "A0A3Q1M4P9", "url": "https://omabrowser.org/oma/group/A0A3Q1M4P9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q1LVV0-1", "protein_name": "Protein FAM83H", "gene_name": "fam83h", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MARRSQSSSLGDNPLDPNYLRPHYREEYRMAIDALVEDDIEGYYNFLQNANVVDFLSRSEIENIKSTVQTPQSAGNVPELPYGEIDQDESSDTYWPLHSDLDAPGLDLGWPMQQHSFVGPTEVTMLVNPAEPERPSIKEQARRLIKNAHQVIAVVMDIFTDVDIFSDLLEAAARHVPVYILLDEQNAHYFVNMVASCKVNLEMIHMMRVRTVSGVTYFCRTGKSFKGQVMDRFLLTDCRAVISGNYSFMWSFEKIHRCIAHLFLGELVATFDEEFRILFAQSQPLVVENALVPMPQDSYLGNQFGLKRTQSLRNPRGYLRQPELGGYQYGDRLDSILPFRRDDPFRHTIEPSAGPMQVTKYATQQFRMQQSFLDQGRSMLASRQLEMNAFKRHSYAEGTRETYASSRQYMKQRVMNNLEETESHYQREQHYYQSEGMGHDDRGHYDRFNYGLADQHSDSGYPPELEAPGNINVLSSDDLKSDSEKQYNIGGRYDPQGHKRPAAGHAYACQSSPTQPHPPDQKQLFSTGDQVRQSQDPSVKQGLRSWRINSYLSTYEDGGEEGLHQPMGSDAFEDSHQQPDSRLYGSEGPGIHSNIRERPNIPTKPNLDLRPRFGKPIIQDRNQVKDNTSDLGPTSTDTLKPAISASSLASSTDNEKELAEPREISITKHESFRTRINPMLQRSSRLRSSLIFSSSKLEQHNSSQAKSGGELQEEKEESEPIRYSSIVAEILEKRRSLSREPFDWNKHKKADEKDVKHASTGDLTTIQDTKEEPIKEKEKPDNPKPEENKVTQPTVPSASQQITSSLNMNDPASRLQYFKDQQEKRKTSKLELDLGTKSQEAAIKKPETLDTATKVPDVLLTSEQSTVKAQEPTVSQTDPVPHRPVIETKPKPSEVSVDRPYTTNKTLTESIADAPKKEPVKEPTKSLKPFPSPKFLKPFKSSQSSSRRISCGEEILTDATDAEKSELKKSRSFSTSGMSRTESRESLSSLGNSESKDTKALDFLKKQTQRLKGILGPKGDKKHSGVSNSQEDKSMKTVPEVQEEISDKGKPSESISSSTAVENKPSAKPTTSRYQSSTSNIIFSSNLRDDTKVILEQISANSQKTRQQNEESGKGDGGKDDVANSPFQSRNRFSRAPVNPQERDNLLKRIESMRKEKKVYSRFEVLYRSREECCWERGSVEQANQFLIKSIE", "length": 1192 }, "evidence": [ { "id": "A0A3Q1M4P9", "url": "https://omabrowser.org/oma/group/A0A3Q1M4P9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6ZRV2-1", "protein_name": "Protein FAM83H", "gene_name": "FAM83H", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALAEGGSEAYSRFLATEGAPDFLCPEELEHVSRHLRPPQYVTREPPEGSLLDVDMDGSSGTYWPVNSDQAVPELDLGWPLTFGFQGTEVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYILLDEMNAQHFLDMADKCRVNLQHVDFLRVRTVAGPTYYCRTGKSFKGHVKEKFLLVDCAVVMSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAAALARMDAYALAPYAGAGPLVGVPGVGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRREEPPRMPGGALEPHAGLRPLSRRLEAEAGPAGELAGARGFFQARHLEMDAFKRHSFATEGAGAVENFAAARQVSRQTFLSHGDDFRFQTSHFHRDQLYQQQYQWDPQLTPARPQGLFEKLRGGRAGFADPDDFTLGAGPRFPELGPDGHQRLDYVPSSASREVRHGSDPAFAPGPRGLEPSGAPRPNLTQRFPCQAAARPGPDPAPEAEPERRGGPEGRAGLRRWRLASYLSGCHGEDGGDDGLPAPMEAEAYEDDVLAPGGRAPAGDLLPSAFRVPAAFPTKVPVPGPGSGGNGPEREGPEEPGLAKQDSFRSRLNPLVQRSSRLRSSLIFSTSQAEGAAGAAAATEKVQLLHKEQTVSETLGPGGEAVRSAASTKVAELLEKYKGPARDPGGGAGAITVASHSKAVVSQAWREEVAAPGAVGGERRSLESCLLDLRDSFAQQLHQEAERQPGAASLTAAQLLDTLGRSGSDRLPSRFLSAQSHSTSPQGLDSPLPLEGSGAHQVLHNESKGSPTSAYPERKGSPTPGFSTRRGSPTTGFIEQKGSPTSAYPERRGSPVPPVPERRSSPVPPVPERRGSLTLTISGESPKAGPAEEGPSGPMEVLRKGSLRLRQLLSPKGERRMEDEGGFPVPQENGQPESPRRLSLGQGDSTEAATEERGPRARLSSATANALYSSNLRDDTKAILEQISAHGQKHRAVPAPSPGPTHNSPELGRPPAAGVLAPDMSDKDKCSAIFRSDSLGTQGRLSRTLPASAEERDRLLRRMESMRKEKRVYSRFEVFCKKEEASSPGAGEGPAEEGTRDSKVGKFVPKILGTFKSKK", "length": 1179 }, "evidence": [ { "id": "A0A3Q1M4P9", "url": "https://omabrowser.org/oma/group/A0A3Q1M4P9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "keratin filament binding", "id": "GO:1990254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990254", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P9" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P9" } ], "pmid": "" }, { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P9" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P9" } ], "pmid": "" }, { "name": "protein localization to cytoskeleton", "id": "GO:0044380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044380", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P9" } ], "pmid": "" }, { "name": "intermediate filament cytoskeleton organization", "id": "GO:0045104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045104", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M4P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4P9" }, { "id": "PF07894", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07894" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Scaffolding anchor of CK1", "eco_id": "ECO_0000259", "start_pos": 205, "end_pos": 474, "start_aa": "Pro", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 893, 950, 1076, 1144, 1182, 1256 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 6 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_o_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 6 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 6 }, { "field": "exact_o_linked_sites", "count": 6 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M4Q5-1", "uniprot_ac": "A0A3Q1M4Q5", "uniprot_id": "A0A3Q1M4Q5_BOVIN", "mass": { "chemical_mass": 41946.0, "monoisotopic_mass": 41946.0 }, "refseq": { "ac": "XP_005201441", "name": "choline-phosphate cytidylyltransferase A isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201441" }, "gene_names": [ { "name": "PCYT1A", "type": "recommended", "evidence": [ { "id": "A0A3Q1M4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q5" } ] }, { "name": "PCYT1A", "type": "synonym", "evidence": [ { "id": "XP_005201441", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201441" } ] } ], "protein_names": [ { "name": "choline-phosphate cytidylyltransferase", "type": "recommended", "evidence": [ { "id": "A0A3Q1M4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q5/entry#names_and_taxonomy" } ] }, { "name": "2.7.7.15", "type": "synonym", "evidence": [ { "id": "A0A3Q1M4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q5/entry#names_and_taxonomy" } ] }, { "name": "choline-phosphate cytidylyltransferase A isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005201441", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201441" } ] } ], "function": [ { "annotation": "Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q5#function" }, { "database": "UniProtKB", "id": "ARBA00025501", "url": "https://www.uniprot.org/uniprotkb/ARBA00025501#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCYT1A", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q5", "locus": { "chromosome": "1", "start_pos": 70824603, "end_pos": 70877084, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016979", "url": "https://www.ensembl.org/id/ENSBTAG00000016979" } ] } } ], "crossref": [ { "id": "A0A3Q1M4Q5", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M4Q5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016979", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016979", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02174", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02174", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100125779", "url": "https://www.ncbi.nlm.nih.gov/gene/100125779", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IWRESKG", "url": "https://omabrowser.org/oma/group/IWRESKG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M4Q5", "url": "https://www.orthodb.org/?gene=A0A3Q1M4Q5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10739", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10739", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10739:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10739:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01467", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01467", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1483191", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483191", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005201441", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201441", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "18997", "url": "https://www.rhea-db.org/rhea/18997", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M4Q5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4Q5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDTQNSAKVNTRKRRKETPGPNGATEEDGIPSKMPRCAIGLRQPAPFSDEIEVDFSKPYVRVTMEEASRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPRQSPSNSPTRERSPSPSFRWPFSGKTSPPSSPTNLSRHKSAAYDISEDEED", "length": 367, "header": "tr|A0A3Q1M4Q5-1|A0A3Q1M4Q5_BOVIN Isoform 1 of choline-phosphate cytidylyltransferase OS=Bos taurus OX=9913 GN=PCYT1A PE=3 SV=1 CANONICAL=A0A3Q1M4Q5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4Q5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q5/entry", "sequence": { "sequence": "MDTQNSAKVNTRKRRKETPGPNGATEEDGIPSKMPRCAIGLRQPAPFSDEIEVDFSKPYVRVTMEEASRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPRQSPSNSPTRERSPSPSFRWPFSGKTSPPSSPTNLSRHKSAAYDISEDEED", "length": 367, "header": "tr|A0A3Q1M4Q5-1|A0A3Q1M4Q5_BOVIN Isoform 1 of choline-phosphate cytidylyltransferase OS=Bos taurus OX=9913 GN=PCYT1A PE=3 SV=1 CANONICAL=A0A3Q1M4Q5-1" }, "locus": { "chromosome": "1", "start_pos": 70857795, "end_pos": 70832038, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076382.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076382.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064803.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064803.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-1483191", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483191", "resource": "Reactome", "description": "Synthesis of PC" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q3AGL8-1", "protein_name": "choline-phosphate cytidylyltransferase", "gene_name": "PCYT1A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEPPTSSRLNSRKRRKDGSGPNGATELDGIPAKMSRRSFGLREPAPFSDEVEIDYSKPYIRVTYEEAMRGTPLDRPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKRVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGNFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTHDRSPSPSFRWPFSTKTPPSSPANRSRNESAVTYDISEDEED", "length": 367 }, "evidence": [ { "id": "A0A3Q1M4Q5", "url": "https://omabrowser.org/oma/group/A0A3Q1M4Q5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P19836-1", "protein_name": "Choline-phosphate cytidylyltransferase A", "gene_name": "Pcyt1a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDAQSSAKVNSRKRRKEVPGPNGATEEDGIPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEACRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTHERSPSPSFRWPFSGKTSPSSSPASLSRCKAVTCDISEDEED", "length": 367 }, "evidence": [ { "id": "A0A3Q1M4Q5", "url": "https://omabrowser.org/oma/group/A0A3Q1M4Q5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P49585-1", "protein_name": "Choline-phosphate cytidylyltransferase A", "gene_name": "PCYT1A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDAQCSAKVNARKRRKEAPGPNGATEEDGVPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEASRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTRERSPSPSFRWPFSGKTSPPCSPANLSRHKAAAYDISEDEED", "length": 367 }, "evidence": [ { "id": "A0A3Q1M4Q5", "url": "https://omabrowser.org/oma/group/A0A3Q1M4Q5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P49586-1", "protein_name": "Choline-phosphate cytidylyltransferase A", "gene_name": "Pcyt1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDAQSSAKVNSRKRRKEAPGPNGATEEDGIPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEACRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKDAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTHERSPSPSFRWPFSGKTSPSSSPASLSRCRAVTCDISEDEED", "length": 367 }, "evidence": [ { "id": "A0A3Q1M4Q5", "url": "https://omabrowser.org/oma/group/A0A3Q1M4Q5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "choline-phosphate cytidylyltransferase activity", "id": "GO:0004105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004105", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q5" } ], "pmid": "" }, { "name": "phosphatidylcholine binding", "id": "GO:0031210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031210", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4Q5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "18997", "name": "", "equation": "phosphocholine + CTP + H(+) = CDP-choline + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1MPA7-1", "A0A3Q1M4Q5-1" ], "evidence": [ { "id": "18997", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18997" } ] }, { "id": "R-BTA-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1MPA7-1", "A0A3Q1M4Q5-1" ], "evidence": [ { "id": "R-BTA-1483081", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483081" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M4Q5", "gene_name": "PCYT1A", "activity": [ { "ec_number": "2.7.7.15", "activity": "phosphocholine + CTP + H(+) = CDP-choline + diphosphate.", "evidence": [ { "id": "A0A3Q1M4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q5" } ] }, { "ec_number": "2.7.7.15", "activity": "", "evidence": [ { "id": "A0A3Q1M4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4Q5" } ] } ] }, { "uniprot_ac": "A0A3Q1MPA7", "gene_name": "PCYT1B", "activity": [ { "ec_number": "2.7.7.15", "activity": 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"sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M4V6-1", "uniprot_ac": "A0A3Q1M4V6", "uniprot_id": "A0A3Q1M4V6_BOVIN", "mass": { "chemical_mass": 49429.0, "monoisotopic_mass": 49429.0 }, "refseq": { "ac": "XP_024848556", "name": "inward rectifier potassium channel 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848556" }, "gene_names": [ { "name": "KCNJ4", "type": "recommended", "evidence": [ { "id": "A0A3Q1M4V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4V6" } ] }, { "name": "KCNJ4", "type": "synonym", "evidence": [ { "id": "XP_024848556", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848556" } ] } ], "protein_names": [ { "name": "Potassium inwardly rectifying channel subfamily J member 4", "type": "synonym", "evidence": [ { "id": "A0A3Q1M4V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4V6/entry#names_and_taxonomy" } ] }, { "name": "inward rectifier potassium channel 4", "type": "synonym", "evidence": [ { "id": "XP_024848556", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848556" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4V6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4V6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCNJ4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4V6", "locus": { "chromosome": "5", "start_pos": 110111809, "end_pos": 110138889, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051965", "url": "https://www.ensembl.org/id/ENSBTAG00000051965" } ] } } ], "crossref": [ { "id": "ENSBTAG00000051965", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051965", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "101906792", "url": "https://www.ncbi.nlm.nih.gov/gene/101906792", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016449", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016449", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041647", "url": 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GN=KCNJ4 PE=3 SV=1 CANONICAL=A0A3Q1M4V6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4V6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4V6/entry", "sequence": { "sequence": "MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEAGPAGAAAGPPAGGSGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQATLPLDNISYRRESAI", "length": 444, "header": "tr|A0A3Q1M4V6-1|A0A3Q1M4V6_BOVIN Isoform 1 of Potassium inwardly rectifying channel subfamily J member 4 OS=Bos taurus OX=9913 GN=KCNJ4 PE=3 SV=1 CANONICAL=A0A3Q1M4V6-1" }, "locus": { "chromosome": "5", "start_pos": 110115856, "end_pos": 110114525, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118513.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118513.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076192.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076192.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101906792", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101906792", "resource": "KEGG Pathway" }, { "id": "R-BTA-1296041", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296041", "resource": "Reactome", "description": "Activation of G protein gated Potassium channels" }, { "id": "R-BTA-1296053", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296053", "resource": "Reactome", "description": "Classical Kir channels" }, { "id": "R-BTA-5576886", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5576886", "resource": "Reactome", "description": "Phase 4 - resting membrane potential" }, { "id": "R-BTA-997272", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-997272", "resource": "Reactome", "description": "Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits" } ], "orthologs": [ { "uniprot_canonical_ac": "E7F807-1", "protein_name": "ATP-sensitive inward rectifier potassium channel 12", "gene_name": "kcnj12b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSVGKPHRYNIVSSSEEDVGRHGTMPALGNGFGNGKIQTRRKLRSRFVNKTGQCNVSFAHMDEQSQRYLADIFTTCVDSRWRWMFLLFSLAFVISWLAFGFAFWLIALVHGDLEKPQENFTPCVMQVNSFVAAFLFSVETQTTIGYGFRCVTEECPLAVFMVVFQSIVGCIIDSFMIGAIMAKMARPKKRAETILFSHNAVISMRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRITEEGEYIPLDQIDINVGYDQGLDRIFLVAPLTILHEINEESPLFGINQQDLETSDFEIVVILEGMVEATAMTAQVRSSYLSSEILWGHRFEPVVFEERNQYKVDYSHFHKTYEVPSTPRCSAKDLEDNKSLESGANFCYENELAFISRDEEEQEEDRGERGTELETLSANLNFDQRSYHKESEI", "length": 421 }, "evidence": [ { "id": "A0A3Q1M4V6", "url": "https://omabrowser.org/oma/group/A0A3Q1M4V6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1SKP8-1", "protein_name": "Potassium inwardly rectifying channel subfamily J member 4", "gene_name": "KCNJ4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEAGPAGATTGSPAGGGGGGGAAPAAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQATLPLDNISYRRESAI", "length": 447 }, "evidence": [ { "id": "A0A3Q1M4V6", "url": "https://omabrowser.org/oma/group/A0A3Q1M4V6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P48050-1", "protein_name": "Inward rectifier potassium channel 4", "gene_name": "KCNJ4", 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"MHGHNRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWWIAFFHGDLEASPSVPAVGGPGGNGGESPNAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQAATLPLDNISYRRESRI", "length": 445 }, "evidence": [ { "id": "A0A3Q1M4V6", "url": "https://omabrowser.org/oma/group/A0A3Q1M4V6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P52190-1", "protein_name": "Inward rectifier potassium channel 4", "gene_name": "Kcnj4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"https://www.uniprot.org/uniprotkb/A0A3Q1M4V6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "potassium ion import across plasma membrane", "id": "GO:1990573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990573", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4V6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4V6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 435, "end_pos": 437, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29463", "name": "", "equation": "K(+)(in) = K(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "29463", "database": "Rhea", "url": 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receptor potential channel 3", "type": "synonym", "evidence": [ { "id": "NP_001098430", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098430" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4W2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4W2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRPC3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4W2", "locus": { "chromosome": "17", "start_pos": 35800518, "end_pos": 35728739, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019021", "url": "https://www.ensembl.org/id/ENSBTAG00000019021" } ] } } ], "crossref": [ { "id": "A0A3Q1M4W2", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M4W2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019021", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019021", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "286866", "url": "https://www.ncbi.nlm.nih.gov/gene/286866", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005459", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005459", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013555", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013555", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056336", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056336", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:286866", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286866", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "REAHSYC", "url": "https://omabrowser.org/oma/group/REAHSYC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M4W2", "url": "https://www.orthodb.org/?gene=A0A3Q1M4W2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MHV0", "url": "https://www.orthodb.org/?gene=F1MHV0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MJ34", "url": "https://www.orthodb.org/?gene=F1MJ34", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10117", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10117:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10117:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23317", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23317", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-114508", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114508", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-139853", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-139853", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3295583", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3295583", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001098430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098430", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M4W2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4W2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4W2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4W2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHV0", "url": "https://www.uniprot.org/uniprotkb/F1MHV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHV0-1", 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"MSSKVRKCKEQARVTFPAPAAEEEDEDEGAEPQRRRRGWRGVNGGLEPRSAPPQRGPRAYCPPPFSPGPDMSMEESPSLRRKTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCTEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESADPLEMHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTVAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKVLRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIINFSKCRRRRLQKDIEMGIGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLSPSVLRCE", "length": 920, "header": "tr|A0A3Q1M4W2-1|A0A3Q1M4W2_BOVIN Isoform 1 of Transient receptor potential cation channel subfamily C member 3 OS=Bos taurus OX=9913 GN=TRPC3 PE=4 SV=1 CANONICAL=A0A3Q1M4W2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M4W2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4W2/entry", "sequence": { "sequence": "MSSKVRKCKEQARVTFPAPAAEEEDEDEGAEPQRRRRGWRGVNGGLEPRSAPPQRGPRAYCPPPFSPGPDMSMEESPSLRRKTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCTEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESADPLEMHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTVAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKVLRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIINFSKCRRRRLQKDIEMGIGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLSPSVLRCE", "length": 920, "header": "tr|A0A3Q1M4W2-1|A0A3Q1M4W2_BOVIN Isoform 1 of Transient receptor potential cation channel subfamily C member 3 OS=Bos taurus OX=9913 GN=TRPC3 PE=4 SV=1 CANONICAL=A0A3Q1M4W2-1" }, "locus": { "chromosome": "17", "start_pos": 35799895, "end_pos": 35728739, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077611.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077611.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068659.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068659.1" } ] } }, { "isoform_ac": "F1MHV0-1", "url": "https://www.uniprot.org/uniprotkb/F1MHV0/entry", "sequence": { "sequence": "MEESPSLRRKTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCTEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESADPLEMHRHKASLSRVKLAIKYEVKKLGKVLRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIINFSKCRRRRLQKDIEMGIGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLSPSVLRCE", "length": 793, "header": "tr|F1MHV0-1|A0A3Q1M4W2_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily C member 3 OS=Bos taurus OX=9913 GN=TRPC3 PE=4 SV=4 CANONICAL=A0A3Q1M4W2-1" }, "locus": { "chromosome": "17", "start_pos": 35799895, "end_pos": 35749638, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039875.6", "url": "https://www.ensembl.org/id/ENSBTAT00000039875.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039660.6", "url": "https://www.ensembl.org/id/ENSBTAP00000039660.6" } ] } }, { "isoform_ac": "F1MJ34-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ34/entry", "sequence": { "sequence": "MEESPSLRRKTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCTEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESADPLEMHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTVAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKVLRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIINFSKCRRRRLQKDIEMGIGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLSPSVLRCE", "length": 848, "header": "tr|F1MJ34-1|A0A3Q1M4W2_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily C member 3 OS=Bos taurus OX=9913 GN=TRPC3 PE=4 SV=4 CANONICAL=A0A3Q1M4W2-1" }, "locus": { "chromosome": "17", "start_pos": 35799895, "end_pos": 35749638, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025316.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025316.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025316.7", "url": "https://www.ensembl.org/id/ENSBTAP00000025316.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:286866", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286866", "resource": "KEGG Pathway" }, { "id": "R-BTA-114508", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114508", "resource": "Reactome", "description": "Effects of PIP2 hydrolysis" }, { "id": "R-BTA-139853", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-139853", "resource": "Reactome", "description": "Elevation of cytosolic Ca2+ levels" }, { "id": "R-BTA-3295583", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3295583", "resource": "Reactome", "description": "TRP channels" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XJK0-1", "protein_name": "Transient receptor potential cation channel subfamily C member 3", "gene_name": "TRPC3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSSKSRKSKEQGRVTFPPQQQQQQQQEEEEEEEAEEEERQRRRRGWRGVNGGLEPPPPPLRAVKTLREPYGYYPPPPFASTMYIEESPSLRRMTMMREKGRRQAIRGPAFMFNNRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYIRIVEAILNHPGFSVNKRLTLSPCEQELQDDDFYSYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCNDCTEKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLNSEPVETQRHRASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGRILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNVTVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARLLAFLQATKAQQYVDNYIEESDLSEVTLPPEIEYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSYYLGAKLNPAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFFYFIMRIINFSKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPNMLRCE", "length": 930 }, "evidence": [ { "id": "A0A3Q1M4W2", "url": "https://omabrowser.org/oma/group/A0A3Q1M4W2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S1U0-1", "protein_name": "Transient receptor potential cation channel subfamily C member 3", "gene_name": "TRPC3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSTKVRKCKEQVRVTFPAPEEEEEESEDEGAEPQRRRRGWRGVNGGLEPRLAPSQREPHGYCPPPFSPRPDMSMEESPSLRRKTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCTEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEMHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTVAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKVLRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIINFSKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLRCE", "length": 921 }, "evidence": [ { "id": "A0A3Q1M4W2", "url": "https://omabrowser.org/oma/group/A0A3Q1M4W2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q13507-2", "protein_name": "Short transient receptor potential channel 3", "gene_name": "TRPC3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSTKVRKCKEQARVTFPAPEEEEDEGEDEGAEPQRRRRGWRGVNGGLEPRSAPSQREPHGYCPPPFSHGPDLSMEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLRCE", "length": 921 }, "evidence": [ { "id": "A0A3Q1M4W2", "url": "https://omabrowser.org/oma/group/A0A3Q1M4W2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JMI9-1", "protein_name": "Short transient receptor potential channel 3", "gene_name": "Trpc3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTKVKKCREPARVTLPAPEEEDGEAEGAEPQRRRRGWRGVNGGLEPPCPRAPPSPGPDASSEGSPSRWRTAGMRDKGRRQAVRGPAFMFGARGPSLTAEEERFLDAAEYGNIPVVRKMLEESRTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILGHPGFAASRRLTLSPCEQELRDDDFYAYDEDGTRFSPDITPIILAAHCHKYEVVHLLLLKGARIERPHDYFCRCADCAEKQRLDAFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESVEPLERHGHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYIVQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSHVQESDLSEVTLPPEVQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSYYLGAKVNPAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRITNFSKCRRRRLQKDLELGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSALRCE", "length": 909 }, "evidence": [ { "id": "A0A3Q1M4W2", "url": "https://omabrowser.org/oma/group/A0A3Q1M4W2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9QZC1-1", "protein_name": "Short transient receptor potential channel 3", "gene_name": "Trpc3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTKVKKCREPARVTLPAPEEEEDGEAEGGESQRRRRGWRGVNGGLEPPCPRAPPSPGPDASSEGSPSRWRTAGMRDKGRRQAVRGPAFMFGARGPSLTAEEERFLDAAEYGNIPVVRKMLEESRTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILGHPGFAASRRLTLSPCEQELRDDDFYAYDEDGTRFSPDITPIILAAHCHKYEVVHLLLLKGARIERPHDYFCRCSDCAEKQRLDAFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLERHGHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYIVQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSHVQESDLSEVTLPPEVQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSYYLGAKVNPAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRITNFSKCRRRRLQKDLELGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSVLRCE", "length": 910 }, "evidence": [ { "id": "A0A3Q1M4W2", "url": "https://omabrowser.org/oma/group/A0A3Q1M4W2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "inositol 1,4,5 trisphosphate binding", "id": "GO:0070679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070679", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4W2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4W2" } ], "pmid": "" }, { "name": "store-operated calcium channel activity", "id": "GO:0015279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015279", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4W2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4W2" } ], "pmid": "" }, { "name": "calcium channel activity", "id": "GO:0005262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4W2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4W2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cation channel complex", "id": "GO:0034703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034703", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4W2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4W2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4W2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4W2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of cytosolic calcium ion concentration", "id": "GO:0051480", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051480", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4W2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4W2" } ], "pmid": "" }, { "name": "single fertilization", "id": "GO:0007338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007338", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4W2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4W2" } ], "pmid": "" }, { "name": "calcium ion transmembrane transport", "id": "GO:0070588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070588", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4W2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4W2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 409, "end_pos": 411, "annotation": "n_glycosylation_sequon" }, { "start_pos": 475, "end_pos": 477, "annotation": "n_glycosylation_sequon" }, { "start_pos": 488, "end_pos": 490, "annotation": "n_glycosylation_sequon" }, { "start_pos": 632, "end_pos": 634, "annotation": "n_glycosylation_sequon" }, { "start_pos": 727, "end_pos": 729, "annotation": "n_glycosylation_sequon" }, { "start_pos": 743, "end_pos": 745, "annotation": "n_glycosylation_sequon" }, { "start_pos": 797, "end_pos": 799, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29671", "name": "", "equation": "Ca(2+)(in) = Ca(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29671" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A3Q1M4W2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 920, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A3Q1M4W2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M4W2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1M4W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4W2" }, { "id": "SM01420", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01420" } ], "ann_type": "Domain_Extent_Annotation", 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"categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MK41", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MK41-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9GKZ4", "url": "https://www.uniprot.org/uniprotkb/Q9GKZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9GKZ4-1", "url": "https://www.uniprot.org/uniprotkb/Q9GKZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAIRKKSSKNPPVLSHEFVLQNHADIVSCVAMVFLLGLMFEITAKVSIIFVTLQYNVTLPATEEQATESAFLYYYGIKDLATVFFYMLVAIIIHAIIQEYVLDKINRRMHFSKTKHSKFNESGQLSAFYLFSCIWGTFILISENYISDPTILWRAYPHNLMTFQMKFFYISQLAYWFHAFPELYFQKTKKEDIPRQLVYIGLYLFHIAGAYLLNLNHLGLVLLVLHYFVEFLFHISRLFYFSDEKYQKGFSLWAVLFVLGRLLTLILSVLTVGFGLARAENQKLDFSTGNFNVLAVRIAVLASICITQAFMMWKFINFQLRRWREHSAFQAPAVKKKPPVTKGRSSRKGTENGVNGTVTSNGADSPRNRKEKSS", "length": 374, "header": "sp|Q9GKZ4-1|TRAM1_BOVIN Isoform 1 of Translocating chain-associated membrane protein 1 OS=Bos taurus OX=9913 GN=TRAM1 PE=2 SV=3 CANONICAL=Q9GKZ4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MK41-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK41/entry", "sequence": { "sequence": "MAIRKKSSKNPPVLSHEFVLQNHADIVSCVAMVFLLGLMFEITAKVSIIFVTLQYNVTLPATEEQATESAFLYYYGIKDLATVFFYMLVAIIIHAIIQEYVLDKINRRMHFSKTKHSKFNESGQLSAFYLFSCIWGTFILISENYISDPTILWRAYPHNLMTFQMKFFYISQLAYWFHAFPELYFQKTKKEDIPRQLVYIGLYLFHIAGAYLLNLNHLGLVLLVLHYFVEFLFHISRLFYFSDEKYQKGFSLWAVLFVLGRLLTLILSVLTVGFGLARAENQKLDFSTGNFNVLAVRIAVLASICITQAFMMWKFINFQLRRWREHSAFQAPAVKKKPPVTKGRSSRKGTDRSPPDSFVHGNLQARIL", "length": 368, "header": "tr|A0A3Q1MK41-1|TRAM1_BOVIN Computationally mapped isoform of Translocating chain-associated membrane protein 1 OS=Bos taurus OX=9913 GN=TRAM1 PE=2 SV=2 CANONICAL=Q9GKZ4-1" }, "locus": { "chromosome": "14", "start_pos": 34307072, "end_pos": 34281768, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078663.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078663.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071202.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071202.2" } ] } }, { "isoform_ac": "Q9GKZ4-1", "url": "https://www.uniprot.org/uniprotkb/Q9GKZ4/entry#Q9GKZ4-1", "sequence": { "sequence": "MAIRKKSSKNPPVLSHEFVLQNHADIVSCVAMVFLLGLMFEITAKVSIIFVTLQYNVTLPATEEQATESAFLYYYGIKDLATVFFYMLVAIIIHAIIQEYVLDKINRRMHFSKTKHSKFNESGQLSAFYLFSCIWGTFILISENYISDPTILWRAYPHNLMTFQMKFFYISQLAYWFHAFPELYFQKTKKEDIPRQLVYIGLYLFHIAGAYLLNLNHLGLVLLVLHYFVEFLFHISRLFYFSDEKYQKGFSLWAVLFVLGRLLTLILSVLTVGFGLARAENQKLDFSTGNFNVLAVRIAVLASICITQAFMMWKFINFQLRRWREHSAFQAPAVKKKPPVTKGRSSRKGTENGVNGTVTSNGADSPRNRKEKSS", "length": 374, "header": "sp|Q9GKZ4-1|TRAM1_BOVIN Isoform 1 of Translocating chain-associated membrane protein 1 OS=Bos taurus OX=9913 GN=TRAM1 PE=2 SV=3 CANONICAL=Q9GKZ4-1" }, "locus": { "chromosome": "14", "start_pos": 34307072, "end_pos": 34274992, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009951.5", "url": "https://www.ensembl.org/id/ENSBTAT00000009951.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009951.4", "url": "https://www.ensembl.org/id/ENSBTAP00000009951.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 56, "start_aa": "Asn", "end_pos": 56, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn56", "evidence": [ { "id": "Q9GKZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GKZ4#ptm_processing" } ], "filter_code": "001000000000000000000.00010000000000.0.01000" } ], "phosphorylation": [ { "start_pos": 365, "end_pos": 365, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9GKZ4", "url": "https://www.uniprot.org/uniprotkb/Q9GKZ4" } ], "site_lbl": "Ser365" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:281546", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281546", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q15629-1", "protein_name": "Translocating chain-associated membrane protein 1", "gene_name": "TRAM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAIRKKSTKSPPVLSHEFVLQNHADIVSCVAMVFLLGLMFEITAKASIIFVTLQYNVTLPATEEQATESVSLYYYGIKDLATVFFYMLVAIIIHAVIQEYMLDKINRRMHFSKTKHSKFNESGQLSAFYLFACVWGTFILISENYISDPTILWRAYPHNLMTFQMKFFYISQLAYWLHAFPELYFQKTKKEDIPRQLVYIGLYLFHIAGAYLLNLNHLGLVLLVLHYFVEFLFHISRLFYFSNEKYQKGFSLWAVLFVLGRLLTLILSVLTVGFGLARAENQKLDFSTGNFNVLAVRIAVLASICVTQAFMMWKFINFQLRRWREHSAFQAPAVKKKPTVTKGRSSKKGTENGVNGTLTSNVADSPRNKKEKSS", "length": 374 }, "evidence": [ { "id": "Q9GKZ4", "url": "https://omabrowser.org/oma/group/Q9GKZ4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5XI41-1", "protein_name": "Translocating chain-associated membrane protein 1", "gene_name": "Tram1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAIRKKSNKNPPVLSHEFVLQNHADIVSCLAMLFLLGLMFEITAKGAIIFVALQYNVTRPATEEQAAESASLYYYGIKDLATVFFYMLVAIIVHAIIQEYVLDKINRRMHFSKTKHSKFNESGQLSAFYLFACVWGTFILVSENYISDPTILWRAYPHNLMTFQMKFFYISQLAYWLHAFPELYFQKTKKEDIPRQLVYIGLYLFHIAGAYLLNLNHLGLVLLVLHYFVEFLFHISRLFYFSDEKYQKGFSLWAVLFVLGRLLTLILSVLTVGFGLARAENQKLDFSTGNFNVLAVRIAVLASICITQAFMMWKFINFQLRRWREHSAFQAPPVKRKPAVTKGRSSRKGTENGVNGTVTSNGADSPRSRKEKSS", "length": 374 }, "evidence": [ { "id": "Q9GKZ4", "url": "https://omabrowser.org/oma/group/Q9GKZ4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P4U7-1", "protein_name": "Translocating chain-associated membrane protein", "gene_name": "tram1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGIRKKTTKNPPVLSHEFVIQNHADIVSCVAMVFLLGLMFEITSKVAVLFITVQYNVTIPANGGPEEATVNYFHYGLKDVATIFFYMLVAIIMHAIIQEYVLDKINRKMHFSKTKHSKFNESGQLSAFYLFSCLWGASILVSENILSNPVSLWDGYPHTLMQFQMKFYYICQLGYWLHAIPELYFQKAKKEDIPRQLVYISLYLVHIAGAYALNLNRLGLVLLVLHYFVELIFHVSRLIYFSNEERQSGFTVWAVLFVLGRLLTLSLSVLTVGFGLAGAEKQGLNLAEGSFNVLFVRVTVLAAICITQAFMMWKFINFQLRRWREQAQTQTLKKKSSSSKSKSKKANGVNGSVGASGADSPRARKEKSS", "length": 369 }, "evidence": [ { "id": "Q9GKZ4", "url": "https://omabrowser.org/oma/group/Q9GKZ4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q91V04-1", "protein_name": "Translocating chain-associated membrane protein 1", "gene_name": "Tram1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAIRKKSNKNPPLLSHEFLLQNHADIVSCLAMLFLLGLMFEVTAKGAIIFVALQYNVTRPATEEQATESASLYHYGIKDLATVLFYMLVAIIIHAIIQEYVLDKINRRMHFSKTKHSKFNESGQLSAFYLFACVWGTFILISENYISDPTILWRAYPHNLMTFQTKFFYISQLAYWLHAFPELYFQKTKKEDIPRQLVYIGLYLFHIAGAYLLNLNHLGLVLLVLHYFVEFLFHISRLFYFSDEKYQKGFSLWAVLFVLGRLLTLILSVLTVGFGLARAENQKLDFSTGNFNVLAVRIAVLASICITQAFMMWKFINFQLRRWREHSAFQAPPVKRKPAVTKGRSSRKGTENGVNGTVTSNGADSPRNRKEKSS", "length": 374 }, "evidence": [ { "id": "Q9GKZ4", "url": "https://omabrowser.org/oma/group/Q9GKZ4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein insertion into ER membrane", "id": "GO:0045048", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045048", "evidence": [ { "database": "UniProtKB", "id": "Q9GKZ4", "url": "https://www.uniprot.org/uniprotkb/Q9GKZ4" } ], "pmid": "" }, { "name": "cotranslational protein targeting to membrane", "id": "GO:0006613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006613", "evidence": [ { "database": "UniProtKB", "id": "Q9GKZ4", "url": "https://www.uniprot.org/uniprotkb/Q9GKZ4" } ], "pmid": "" }, { "name": "response to unfolded protein", "id": "GO:0006986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006986", "evidence": [ { "database": "UniProtKB", "id": "Q9GKZ4", "url": "https://www.uniprot.org/uniprotkb/Q9GKZ4" } ], "pmid": "" }, { "name": "SRP-dependent cotranslational protein targeting to membrane, translocation", "id": "GO:0006616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006616", "evidence": [ { "database": "UniProtKB", "id": "Q9GKZ4", "url": "https://www.uniprot.org/uniprotkb/Q9GKZ4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q9GKZ4", "url": "https://www.uniprot.org/uniprotkb/Q9GKZ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9GKZ4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 374, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9GKZ4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9GKZ4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q9GKZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GKZ4" }, { "id": "PRU00205", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00205" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TLC", "eco_id": "ECO_0000255", "start_pos": 117, "end_pos": 326, "start_aa": "Ser", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 56 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 365 ], "sequon_annotation_sites": [ { "start_pos": 120, "end_pos": 122 }, { "start_pos": 355, "end_pos": 357 }, { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q9GLX9-1", "uniprot_ac": "Q9GLX9", "uniprot_id": "SPON1_BOVIN", "mass": { "chemical_mass": 90976.0, "monoisotopic_mass": 90976.0 }, "refseq": { "ac": "NP_777168", "name": "spondin-1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777168" }, "gene_names": [ { "name": "SPON1", "type": "recommended", "evidence": [ { "id": "Q9GLX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9" } ] }, { "name": "SPON1", "type": "synonym", "evidence": [ { "id": "NP_777168", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777168" } ] }, { "name": "VSGP", "type": "synonym", "evidence": [ { "id": "Q9GLX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9" } ] } ], "protein_names": [ { "name": "Spondin-1", "type": "recommended", "evidence": [ { "id": "Q9GLX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9/entry#names_and_taxonomy" } ] }, { "name": "F-spondin", "type": "synonym", "evidence": [ { "id": "NP_777168", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777168" }, { "id": "Q9GLX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9/entry#names_and_taxonomy" } ] }, { "name": "Vascular smooth muscle cell growth-promoting factor", "type": "synonym", "evidence": [ { "id": "Q9GLX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9/entry#names_and_taxonomy" } ] }, { "name": "spondin 1, (f-spondin) extracellular matrix protein", "type": "synonym", "evidence": [ { "id": "NP_777168", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777168" } ] }, { "name": "spondin 1, extracellular matrix protein", "type": "synonym", "evidence": [ { "id": "NP_777168", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777168" } ] }, { "name": "spondin-1 precursor", "type": "synonym", "evidence": [ { "id": "NP_777168", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777168" } ] }, { "name": "vascular smooth muscle cell growth-promoting factor", "type": "synonym", "evidence": [ { "id": "NP_777168", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777168" } ] } ], "function": [ { "annotation": "Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.", "evidence": [ { "database": "UniProtKB", "id": "Q9GLX9", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9GLX9", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SPON1", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9", "locus": { "chromosome": "15", "start_pos": 38457984, "end_pos": 38773001, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009150", "url": "https://www.ensembl.org/id/ENSBTAG00000009150" } ] } } ], "crossref": [ { "id": "Q9GLX9", "url": "https://alphafold.ebi.ac.uk/entry/Q9GLX9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009150", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009150", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08544", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08544", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282866", "url": "https://www.ncbi.nlm.nih.gov/gene/282866", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002861", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002861", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038678", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038678", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042307", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042307", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282866", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282866", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IPRIEGC", "url": "https://omabrowser.org/oma/group/IPRIEGC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MVH8", "url": "https://www.orthodb.org/?gene=A0A3Q1MVH8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q9GLX9", "url": "https://www.orthodb.org/?gene=Q9GLX9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11311", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11311", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11311:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11311:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00090", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00090", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02014", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02014", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06468", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06468", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5173214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_777168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777168", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVH8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVH8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVH8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9GLX9", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9GLX9-1", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLSPVLLRLSRGPALLALALPLAVALAFSDETLDKVPKSEGYCSRILRVQGTRREGYTEFSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALKENREGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKKLCEQDSTFDGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGTGTRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLTTEWGEWDECSATCGMGMKKRHRMVKMSPADGSMCKAETSQAEKCMMPECHTIPCLLSLWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEELEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHMIRTRMIQMEPQFGGTPCPETVQRKKCRIRKCLRNPSIQNLRWREARESRRSEQLREESDGDQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC", "length": 807, "header": "sp|Q9GLX9-1|SPON1_BOVIN Isoform 1 of Spondin-1 OS=Bos taurus OX=9913 GN=SPON1 PE=1 SV=1 CANONICAL=Q9GLX9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MVH8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVH8/entry", "sequence": { "sequence": "MRLSPVLLRLSRGPALLALALPLAVALAFSDETLDKVPKSEGYCSRILRVQGTRREGYTEFSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALKENREGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKKLCEQDSTFDGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGTGTRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLTTEWGEWDECSATCGMGMKKRHRMVKMSPADGSMCKAETSQAEKCMMPECPIDCELTEWSQWSECNKSCGKGHMIRTRMIQMEPQFGGTPCPETVQRKKCRIRKCLRNPSIQNLRWREARESRRSEQLREESDGDQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC", "length": 752, "header": "tr|A0A3Q1MVH8-1|SPON1_BOVIN Computationally mapped isoform of Spondin-1 OS=Bos taurus OX=9913 GN=SPON1 PE=1 SV=1 CANONICAL=Q9GLX9-1" }, "locus": { "chromosome": "15", "start_pos": 38772873, "end_pos": 38459498, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067426.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067426.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059048.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059048.1" } ] } }, { "isoform_ac": "Q9GLX9-1", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9/entry#Q9GLX9-1", "sequence": { "sequence": "MRLSPVLLRLSRGPALLALALPLAVALAFSDETLDKVPKSEGYCSRILRVQGTRREGYTEFSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALKENREGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKKLCEQDSTFDGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGTGTRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLTTEWGEWDECSATCGMGMKKRHRMVKMSPADGSMCKAETSQAEKCMMPECHTIPCLLSLWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEELEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHMIRTRMIQMEPQFGGTPCPETVQRKKCRIRKCLRNPSIQNLRWREARESRRSEQLREESDGDQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC", "length": 807, "header": "sp|Q9GLX9-1|SPON1_BOVIN Isoform 1 of Spondin-1 OS=Bos taurus OX=9913 GN=SPON1 PE=1 SV=1 CANONICAL=Q9GLX9-1" }, "locus": { "chromosome": "15", "start_pos": 38772873, "end_pos": 38459498, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012059.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012059.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012059.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012059.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 214, "start_aa": "Asn", "end_pos": 214, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn214", "evidence": [ { "id": "Q9GLX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9#ptm_processing" } ], "filter_code": "001000000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 681, "start_aa": "Asn", "end_pos": 681, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn681", "evidence": [ { "id": "Q9GLX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9#ptm_processing" } ], "filter_code": "001000000000000000000.00010000000000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary.", "journal": "Arch. Biochem. Biophys.", "date": "2001", "authors": "Miyamoto K, Morishita Y, Yamazaki M, Minamino N, Kangawa K, Matsuo H, Mizutani T, Yamada K, Minegishi T", "evidence": [ { "database": "UniProtKB", "id": "Q9GLX9", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9" } ], "reference": [ { "type": "PubMed", "id": "11368520", "url": "https://glygen.org/publication/PubMed/11368520" } ] } ], "pathway": [ { "id": "bta:282866", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282866", "resource": "KEGG Pathway" }, { "id": "R-BTA-5173214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "resource": "Reactome", "description": "O-glycosylation of TSR domain-containing proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TLK4-1", "protein_name": "Spondin-1", "gene_name": "SPON1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRLSPASVKLSGSPALLALALPLAAALAFSDETLDKVPKSEGYCSRILRVQGTRREGYTEFSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALKENREGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKKVCEQDSTFDGVTDRPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGTGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMVKMSPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEELEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHMIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRSEQLREESDGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC", "length": 807 }, "evidence": [ { "id": "Q9GLX9", "url": "https://omabrowser.org/oma/group/Q9GLX9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZXW0-1", "protein_name": "Spondin-1", "gene_name": "SPON1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAARLRPLALRLLALTFPLVARGFSDETLEKAAKSEGYCSRILRAQGTRREGYNEFSLRVEGDPEFYKPGNSYRVTLSAATPAYFRGFTLIALKEGKEGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWTAPPTGTGCVILKASIVQKRIIYFQDEGSLTKRICEQDSASEGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDFPRRTNHWSAIIGSSHSKNYILWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAAPSAEFSVDRHRHLMSFLTMLGPSPDWNVGLSAEDLCTKDCGWVQKVVQDLIPWDAGTDSGVTYESPNKPTVPQEKIRPLTSLDHPQSPFYDPEGGSIKLVARVVIERIARKGEQCNIVPDNIDDIVADLAPEEKEEDDTPETCIYSNWSPWSACSSSTCEKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCMMSDWITWSPCSVSCGMGTRSRERYVKQFPEDGSMCKVPTEETEKCIVNEECSPSSCLVTEWGEWDECSASCGTGMKRRHRMIKMTPADGSMCKAETTEAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSAAELGDCNEELEQAEKCMLPECPIDCELTEWSQWSECNTSCGKGHMIRTRMIKIEPQFGGTACPETVQRTKCRVRKCLRGPGMEKRRWKEAREKRRSEQAKKNIDNEQYPVCRLKPWTAWTECSTLCGGGIQERYMMVKKRSKSTQFTSCKDKKELRACNVHPC", "length": 802 }, "evidence": [ { "id": "Q9GLX9", "url": "https://omabrowser.org/oma/group/Q9GLX9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P35446-1", "protein_name": "Spondin-1", "gene_name": "Spon1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRLSPAPLRLSRGPALLALALPLAAALAFSDETLDKVAKSEGYCSRILRAQGTRREGYTEFSLRVEGDPDFYKPGSSYRVTLSAAPPSYFRGFTLIALKENREGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPTGTGCVILKASIVQKRIIYFQDEGSLTKKLCEQDPTLDGVTDRPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPSWQPVNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCEKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSVSCGMGMRSRERYVKQFPEDGSVCMLPTEETEKCTVNEECSPSSCLVTEWGEWDDCSATCGMGMKKRHRMVKMSPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQAEKCMLPECPIDCELSEWSQWSECNKSCGKGHMIRTRTIQMEPQFGGAPCPETVQRKKCRARKCLRSPSIQKLRWREARESRRSEQLREESDGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC", "length": 807 }, "evidence": [ { "id": "Q9GLX9", "url": "https://omabrowser.org/oma/group/Q9GLX9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VCC9-1", "protein_name": "Spondin-1", "gene_name": "Spon1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRLSPVSLRLSRGPALLALALPLAAALAFSDETLDKVTKSEGYCSRILRAQGTRREGYTEFSLRVEGDPDFYKPGSSYRVTLSAAPPSYFRGFTLIALKENQEGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPTGTGCVILKASIVQKRIIYFQDEGSLTKKLCEQDPTLDGVTDRPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPVNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCEKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSVSCGMGMRSRERYVKQFPEDGSVCMLPTEETEKCTVNEECSPSSCLVTEWGEWDDCSATCGMGMKKRHRMVKMSPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQAEKCMLPECPIDCELSEWSQWSECNKSCGKGHMIRTRTIQMEPQFGGVPCPETVQRKKCRTRKCLRSPSVQKLRWREARESRRSEQLREESDGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC", "length": 807 }, "evidence": [ { "id": "Q9GLX9", "url": "https://omabrowser.org/oma/group/Q9GLX9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HCB6-1", "protein_name": "Spondin-1", "gene_name": "SPON1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRLSPAPLKLSRTPALLALALPLAAALAFSDETLDKVPKSEGYCSRILRAQGTRREGYTEFSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALRENREGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKKLCEQDSTFDGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC", "length": 807 }, "evidence": [ { "id": "Q9GLX9", "url": "https://omabrowser.org/oma/group/Q9GLX9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "LBD domain binding", "id": "GO:0050693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050693", "evidence": [ { "database": "UniProtKB", "id": "Q9GLX9", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q9GLX9", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "Q9GLX9", "url": "https://www.uniprot.org/uniprotkb/Q9GLX9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular matrix", "id": "GO:0031012", "url": 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"MEAPPPPPPLPATTLAPGRSRKLLLLPLLLFLLRAEAVRGFEAEERPRTREEECHFYAGGQVYPGEVSRVSVAEHSLHLSKAKISKPAPYWEGTAVINGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRIDEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGSINIPLLADLNHQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN", "length": 274, "header": "sp|Q9BGI2-1|PRDX4_BOVIN Isoform 1 of Peroxiredoxin-4 OS=Bos taurus OX=9913 GN=PRDX4 PE=2 SV=1 CANONICAL=Q9BGI2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LW10-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW10/entry", "sequence": { "sequence": "MEAPPPPPPLPATTLAPGRSRKLLLLPLLLFLLRAEAVRGFEAEERPRTREEECHFYAGGQVYPGEVSRVSVAEHSLHLSKAKISKPAPYWEGTAVINGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRIDEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGSINIPLLADLNHQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETVVAYHHFISRLFYKCINICSHAPLMCLI", "length": 286, "header": "tr|A0A3Q1LW10-1|A0A3Q1LW10_BOVIN Computationally mapped isoform of thioredoxin-dependent peroxiredoxin OS=Bos taurus OX=9913 GN=PRDX4 PE=3 SV=2 CANONICAL=Q9BGI2-1" }, "locus": { "chromosome": "X", "start_pos": 119528677, "end_pos": 119516200, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076933.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076933.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061615.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061615.2" } ] } }, { "isoform_ac": "A0A452DI43-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DI43/entry", "sequence": { "sequence": "MEAPPPPPPLPATTLAPGRSRKLLLLPLLLFLLRAEAVRGFEAEERPRTREEECHFYAGGQVYPGEVSRVSVAEHSLHLSKAKISKPAPYWEGTAVINGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRIDEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGSINIPLLADLNHQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIKPEDAMKAWWRREEL", "length": 274, "header": "tr|A0A452DI43-1|PRDX4_BOVIN Computationally mapped isoform of Peroxiredoxin-4 OS=Bos taurus OX=9913 GN=PRDX4 PE=2 SV=1 CANONICAL=Q9BGI2-1" }, "locus": { "chromosome": "X", "start_pos": 119528677, "end_pos": 119515883, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008107.3", "url": "https://www.ensembl.org/id/ENSBTAT00000008107.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008107.3", "url": "https://www.ensembl.org/id/ENSBTAP00000008107.3" } ] } }, { "isoform_ac": "Q9BGI2-1", "url": "https://www.uniprot.org/uniprotkb/Q9BGI2/entry#Q9BGI2-1", "sequence": { "sequence": "MEAPPPPPPLPATTLAPGRSRKLLLLPLLLFLLRAEAVRGFEAEERPRTREEECHFYAGGQVYPGEVSRVSVAEHSLHLSKAKISKPAPYWEGTAVINGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRIDEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGSINIPLLADLNHQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN", "length": 274, "header": "sp|Q9BGI2-1|PRDX4_BOVIN Isoform 1 of Peroxiredoxin-4 OS=Bos taurus OX=9913 GN=PRDX4 PE=2 SV=1 CANONICAL=Q9BGI2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:281999", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281999", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI2", "url": "https://www.uniprot.org/uniprotkb/Q9BGI2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI2", "url": "https://www.uniprot.org/uniprotkb/Q9BGI2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "response to oxidative stress", "id": "GO:0006979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006979", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI2", "url": "https://www.uniprot.org/uniprotkb/Q9BGI2" } ], "pmid": "" }, { "name": "cell redox homeostasis", "id": "GO:0045454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045454", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI2", "url": "https://www.uniprot.org/uniprotkb/Q9BGI2" } ], "pmid": "" }, { "name": "hydrogen peroxide catabolic process", "id": "GO:0042744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042744", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI2", "url": "https://www.uniprot.org/uniprotkb/Q9BGI2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "thioredoxin peroxidase activity", "id": "GO:0008379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008379", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI2", "url": "https://www.uniprot.org/uniprotkb/Q9BGI2" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI2", "url": "https://www.uniprot.org/uniprotkb/Q9BGI2" } ], "pmid": "" }, { "name": "molecular sequestering activity", "id": "GO:0140313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140313", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI2", "url": "https://www.uniprot.org/uniprotkb/Q9BGI2" } ], "pmid": "" }, { "name": "thioredoxin-dependent peroxiredoxin activity", "id": "GO:0140824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140824", "evidence": [ { "database": "UniProtKB", "id": "Q9BGI2", "url": "https://www.uniprot.org/uniprotkb/Q9BGI2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "62620", "name": "", "equation": "a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35705-1", "Q5E947-1", "Q9BGI1-1", "Q9BGI2-1", "Q9BGI3-1" ], "evidence": [ { "id": "62620", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/62620" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P35705", "gene_name": "PRDX3", "activity": [ { "ec_number": "1.11.1.24", "activity": "a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O.", "evidence": [ { "id": "P35705", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35705" } ] }, { "ec_number": "1.11.1.24", "activity": "", "evidence": [ { "id": "P35705", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35705" } ] } ] }, { "uniprot_ac": "Q5E947", "gene_name": "PRDX1", "activity": [ { "ec_number": "1.11.1.24", "activity": "a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O.", "evidence": [ { "id": "Q5E947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E947" } ] }, { "ec_number": "1.11.1.24", "activity": "", "evidence": [ { "id": "Q5E947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E947" } ] } ] }, { "uniprot_ac": "Q9BGI1", "gene_name": "PRDX5", "activity": [ { "ec_number": "1.11.1.24", "activity": "a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O.", "evidence": [ { "id": "Q9BGI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BGI1" } ] }, { "ec_number": "1.11.1.24", "activity": "", "evidence": [ { "id": "Q9BGI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BGI1" } ] } ] }, { "uniprot_ac": "Q9BGI2", "gene_name": "PRDX4", "activity": [ { "ec_number": "1.11.1.24", "activity": "a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O.", "evidence": [ { "id": "Q9BGI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BGI2" } ] }, { "ec_number": "1.11.1.24", "activity": "", "evidence": [ { "id": "Q9BGI2", "database": "UniProtKB", "url": 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"https://www.uniprot.org/uniprotkb/Q9BGI2" }, { "id": "PRU00691", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00691" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Thioredoxin", "eco_id": "ECO_0000255", "start_pos": 82, "end_pos": 240, "start_aa": "Ala", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "1.11.1.24", "ec_name": "a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O.", "evidence": [ { "id": "1.11.1.24", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24" }, { "id": "1.11.1.24", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.11.1.24" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q9BDI3-1", "uniprot_ac": "Q9BDI3", "uniprot_id": "CITE1_BOVIN", "mass": { "chemical_mass": 19998.0, "monoisotopic_mass": 19998.0 }, "refseq": { "ac": "NP_776943", "name": "cbp/p300-interacting transactivator 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776943" }, "gene_names": [ { "name": "CITED1", "type": "recommended", "evidence": [ { "id": "Q9BDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ] }, { "name": "CITED1", "type": "synonym", "evidence": [ { "id": "NP_776943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776943" } ] }, { "name": "MSG1", "type": "synonym", "evidence": [ { "id": "Q9BDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ] } ], "protein_names": [ { "name": "Cbp/p300-interacting transactivator 1", "type": "recommended", "evidence": [ { "id": "Q9BDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3/entry#names_and_taxonomy" } ] }, { "name": "Melanocyte-specific protein 1", "type": "synonym", "evidence": [ { "id": "Q9BDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3/entry#names_and_taxonomy" } ] }, { "name": "cbp/p300-interacting transactivator 1", "type": "synonym", "evidence": [ { "id": "NP_776943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776943" } ] }, { "name": "melanocyte-specific protein 1", "type": "synonym", "evidence": [ { "id": "NP_776943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776943" } ] }, { "name": "transactivator, with Glu/Asp-rich carboxy-terminal domain, 1", "type": "synonym", "evidence": [ { "id": "NP_776943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776943" } ] }, { "name": "transcription factor-like protein", "type": "synonym", "evidence": [ { "id": "NP_776943", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776943" } ] } ], "function": [ { "annotation": "Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CITED1", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3", "locus": { "chromosome": "X", "start_pos": 78370098, "end_pos": 78364719, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000045925", "url": "https://www.ensembl.org/id/ENSBTAG00000045925" } ] } } ], "crossref": [ { "id": "Q9BDI3", "url": "https://alphafold.ebi.ac.uk/entry/Q9BDI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000045925", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000045925", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "282182", "url": "https://www.ncbi.nlm.nih.gov/gene/282182", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007576", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007576", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282182", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282182", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NSQYHGV", "url": "https://omabrowser.org/oma/group/NSQYHGV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJK8", "url": "https://www.orthodb.org/?gene=A0A452DJK8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q9BDI3", "url": "https://www.orthodb.org/?gene=Q9BDI3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR17045", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17045", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR17045:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17045:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04487", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04487", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8866907", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8866907", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9018519", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9018519", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_776943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776943", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A452DJK8", "url": "https://www.uniprot.org/uniprotkb/A0A452DJK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJK8-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7C5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7C5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2E3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2E3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9BDI3-1", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPTMSRPALDVKGGTSPVKENANPEMNSLAYSNLGVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPSPISSSTATPPTKPPPFNLHPAPHLLASMQLQKLNSQYHGMAAATPGQPGEAEPLPNWGFGAQAGGAGSLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSGS", "length": 195, "header": "sp|Q9BDI3-1|CITE1_BOVIN Isoform 1 of Cbp/p300-interacting transactivator 1 OS=Bos taurus OX=9913 GN=CITED1 PE=2 SV=1 CANONICAL=Q9BDI3-1" }, "isoforms": [ { "isoform_ac": "A0A452DJK8-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJK8/entry", "sequence": { "sequence": "MEPSTQQLQLAASPPTNLSNFCQDSEMPTMSRPALDVKGGTSPVKENANPEMNSLAYSNLGVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPSPISSSTATPPTKPPPFNLHPAPHLLASMQLQKLNSQYHGMAAATPGQPGEAEPLPNWGFGAQAGGAGSLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSGS", "length": 221, "header": "tr|A0A452DJK8-1|CITE1_BOVIN Computationally mapped isoform of Cbp/p300-interacting transactivator 1 OS=Bos taurus OX=9913 GN=CITED1 PE=2 SV=2 CANONICAL=Q9BDI3-1" }, "locus": { "chromosome": "X", "start_pos": 78370012, "end_pos": 78366549, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063543.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063543.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055759.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055759.3" } ] } }, { "isoform_ac": "A0AAA9S7C5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7C5/entry", "sequence": { "sequence": "MWVAGCPGSTWPNQAPFPPQAKVPAEILCSAQQLQLAASPPTNLSNFCQDSEMPTMSRPALDVKGGTSPVKENANPEMNSLAYSNLGVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPSPISSSTATPPTKPPPFNLHPAPHLLASMQLQKLNSQYHGMAAATPGQPGEAEPLPNWGFGAQAGGAGSLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSGS", "length": 247, "header": "tr|A0AAA9S7C5-1|CITE1_BOVIN Computationally mapped isoform of Cbp/p300-interacting transactivator 1 OS=Bos taurus OX=9913 GN=CITED1 PE=2 SV=1 CANONICAL=Q9BDI3-1" }, "locus": { "chromosome": "X", "start_pos": 78370012, "end_pos": 78368557, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098387.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098387.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081904.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081904.1" } ] } }, { "isoform_ac": "A0AAA9T2E3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E3/entry", "sequence": { "sequence": "MPVAGLGRSRSPSLSELRTWRKTDLAANPGSPLSSAVTLAQQLQLAASPPTNLSNFCQDSEMPTMSRPALDVKGGTSPVKENANPEMNSLAYSNLGVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPSPISSSTATPPTKPPPFNLHPAPHLLASMQLQKLNSQYHGMAAATPGQPGEAEPLPNWGFGAQAGGAGSLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSGS", "length": 256, "header": "tr|A0AAA9T2E3-1|CITE1_BOVIN Computationally mapped isoform of Cbp/p300-interacting transactivator 1 OS=Bos taurus OX=9913 GN=CITED1 PE=2 SV=1 CANONICAL=Q9BDI3-1" }, "locus": { "chromosome": "X", "start_pos": 78370012, "end_pos": 78365915, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114152.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114152.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089832.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089832.1" } ] } }, { "isoform_ac": "Q9BDI3-1", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3/entry#Q9BDI3-1", "sequence": { "sequence": "MPTMSRPALDVKGGTSPVKENANPEMNSLAYSNLGVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPSPISSSTATPPTKPPPFNLHPAPHLLASMQLQKLNSQYHGMAAATPGQPGEAEPLPNWGFGAQAGGAGSLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSGS", "length": 195, "header": "sp|Q9BDI3-1|CITE1_BOVIN Isoform 1 of Cbp/p300-interacting transactivator 1 OS=Bos taurus OX=9913 GN=CITED1 PE=2 SV=1 CANONICAL=Q9BDI3-1" }, "locus": { "chromosome": "X", "start_pos": 78370012, "end_pos": 78368850, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000062996.3", "url": "https://www.ensembl.org/id/ENSBTAT00000062996.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055749.1", "url": "https://www.ensembl.org/id/ENSBTAP00000055749.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 77, "start_aa": "Thr", "end_pos": 77, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr77", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:282182", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282182", "resource": "KEGG Pathway" }, { "id": "R-BTA-8866907", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8866907", "resource": "Reactome", "description": "Activation of the TFAP2 (AP-2) family of transcription factors" }, { "id": "R-BTA-9018519", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9018519", "resource": "Reactome", "description": "Estrogen-dependent gene expression" } ], "orthologs": [ { "uniprot_canonical_ac": "P97769-1", "protein_name": "Cbp/p300-interacting transactivator 1", "gene_name": "Cited1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPTMSRPALDVKGGTTSGKEDANQEMNSLAYSNLGVKDRKAVTVLHYPGVTANGAKANGVPTSSSGSTSPIGSPTATPSSKPPSFNLHPTPHLMASMQLQKLNSQYQGAAATAAAALTGAGLPGEEEPMQNWVTAPLVVGGSPGSVSPPAGAQSPALIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSGC", "length": 203 }, "evidence": [ { "id": "Q9BDI3", "url": "https://omabrowser.org/oma/group/Q9BDI3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q4V8P1-1", "protein_name": "Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1", "gene_name": "Cited1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPTMSRPALDVKGGTTSGKEDANQEMNSLAYSNLGVKDRKAVTVLHYPGVTANGAKANGVPTSPSGSSSPTGSPTATPSTKPPSFNLHPTPHLLASMQLQKLNSQYQGAAATAAAALAAPSQPGEDEPLLNWGTGIQAGAGGSPGSVSPAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSGC", "length": 203 }, "evidence": [ { "id": "Q9BDI3", "url": "https://omabrowser.org/oma/group/Q9BDI3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99966-1", "protein_name": "Cbp/p300-interacting transactivator 1", "gene_name": "CITED1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPTTSRPALDVKGGTSPAKEDANQEMSSVAYSNLAVKDRKAVAILHYPGVASNGTKASGAPTSSSGSPIGSPTTTPPTKPPSFNLHPAPHLLASMHLQKLNSQYQGMAAATPGQPGEAGPLQNWDFGAQAGGAESLSPSAGAQSPAIIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSSC", "length": 193 }, "evidence": [ { "id": "Q9BDI3", "url": "https://omabrowser.org/oma/group/Q9BDI3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 30, "go_terms": [ { "name": "response to transforming growth factor beta", "id": "GO:0071559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071559", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "nucleocytoplasmic transport", "id": "GO:0006913", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006913", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "negative regulation of neuron apoptotic process", "id": "GO:0043524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043524", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "branching involved in ureteric bud morphogenesis", "id": "GO:0001658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001658", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "melanocyte differentiation", "id": "GO:0030318", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030318", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "response to interleukin-2", "id": "GO:0070669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070669", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "response to interleukin-9", "id": "GO:0071104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071104", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "response to interleukin-11", "id": "GO:0071105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071105", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "response to lipopolysaccharide", "id": "GO:0032496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032496", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "transforming growth factor beta receptor signaling pathway", "id": "GO:0007179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007179", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "placenta development", "id": "GO:0001890", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001890", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "response to insulin", "id": "GO:0032868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "SMAD protein signal transduction", "id": "GO:0060395", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060395", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "response to estrogen", "id": "GO:0043627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043627", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "response to cAMP", "id": "GO:0051591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051591", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "response to interleukin-1", "id": "GO:0070555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070555", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "negative regulation of osteoblast differentiation", "id": "GO:0045668", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045668", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "melanin biosynthetic process", "id": "GO:0042438", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042438", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "response to interleukin-6", "id": "GO:0070741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070741", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "response to type II interferon", "id": "GO:0034341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034341", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "response to interleukin-4", "id": "GO:0070670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070670", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": "response to parathyroid hormone", "id": "GO:0071107", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071107", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "Q9BDI3", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "pmid": "" }, { "name": 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"annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9BDI3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 195, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9BDI3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9BDI3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "Q9BDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BDI3" } ], "ann_type": "Motif_Annotation", "uniprotkb_annotation": "Nuclear export signal", "eco_id": "ECO_0000250", "start_pos": 160, "end_pos": 169, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { 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"Glycoproteomics" ] }, { "id": "IPR003936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534497", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534497", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HTADLWQ", "url": "https://omabrowser.org/oma/group/HTADLWQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q9TQZ3", "url": "https://www.orthodb.org/?gene=Q9TQZ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10671", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10671", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10671:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10671:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00822", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00822", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001094626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094626", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S6Z6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Z6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Z6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STB6", "url": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9TQZ3", "url": "https://www.uniprot.org/uniprotkb/Q9TQZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9TQZ3-1", "url": "https://www.uniprot.org/uniprotkb/Q9TQZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLLLLGIIVLHVAVLVLLFVSTIVSQWMVGNGHATDLWQNCSTSLMGSVQHCFSSSANEWLQSVQATMILSIIFSVLSLFLFFCQLFTLTKGGRFYITGVFQILAGLCVMSAASIYTVRHPEWHFNSDGSYGFAYILAWVAFPLALLSGVIYVILRKRE", "length": 160, "header": "sp|Q9TQZ3-1|PMP22_BOVIN Isoform 1 of Peripheral myelin protein 22 OS=Bos taurus OX=9913 GN=PMP22 PE=1 SV=2 CANONICAL=Q9TQZ3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S6Z6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6Z6/entry", "sequence": { "sequence": "MTFKSGKVNSLSFIQKRAAAPGSGCGFLLPRPRPLEEPRPSGWLVPPFPNPVSPPLEWLQSVQATMILSIIFSVLSLFLFFCQLFTLTKGGRFYITGVFQILAGLCVMSAASIYTVRHPEWHFNSDGSYGFAYILAWVAFPLALLSGVIYVILRKRE", "length": 157, "header": "tr|A0AAA9S6Z6-1|PMP22_BOVIN Computationally mapped isoform of Peripheral myelin protein 22 OS=Bos taurus OX=9913 GN=PMP22 PE=1 SV=1 CANONICAL=Q9TQZ3-1" }, "locus": { "chromosome": "19", "start_pos": 32764141, "end_pos": 32756780, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097213.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097213.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079685.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079685.1" } ] } }, { "isoform_ac": "A0AAA9STB6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STB6/entry", "sequence": { "sequence": "MQIQGPPYPLHVISLFSIFLDGAGEQWMVGNGHATDLWQNCSTSLMGSVQHCFSSSANEWLQSVQATMILSIIFSVLSLFLFFCQLFTLTKGGRFYITGVFQILAGLCVMSAASIYTVRHPEWHFNSDGSYGFAYILAWVAFPLALLSGVIYVILRKRE", "length": 159, "header": "tr|A0AAA9STB6-1|PMP22_BOVIN Computationally mapped isoform of Peripheral myelin protein 22 OS=Bos taurus OX=9913 GN=PMP22 PE=1 SV=1 CANONICAL=Q9TQZ3-1" }, "locus": { "chromosome": "19", "start_pos": 32779329, "end_pos": 32756780, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132735.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132735.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088595.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088595.1" } ] } }, { "isoform_ac": "A0AAA9SWD5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWD5/entry", "sequence": { "sequence": "MLLLLLGIIVLHVAVLVLLFVSTIVSQWMVGNGHATDLWQNCSTSLMGSVQHCFSSSANGLCVMSAASIYTVRHPEWHFNSDGSYGFAYILAWVAFPLALLSGVIYVILRKRE", "length": 113, "header": "tr|A0AAA9SWD5-1|PMP22_BOVIN Computationally mapped isoform of Peripheral myelin protein 22 OS=Bos taurus OX=9913 GN=PMP22 PE=1 SV=1 CANONICAL=Q9TQZ3-1" }, "locus": { "chromosome": "19", "start_pos": 32779668, "end_pos": 32756780, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105603.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105603.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089638.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089638.1" } ] } }, { "isoform_ac": "A0AAA9SXN2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXN2/entry", "sequence": { "sequence": "MLLLLLGIIVLHVAVLVLLFVSTIVSQWMVGNGHATDLWQNCSTSLMGSVQHCFSSSANEWLQSVQATMILSIIFSVLSLFLFFCQLFTLTKGGRFYITGVFQILAGKLERTKFPGLGSPRLHAGW", "length": 126, "header": "tr|A0AAA9SXN2-1|PMP22_BOVIN Computationally mapped isoform of Peripheral myelin protein 22 OS=Bos taurus OX=9913 GN=PMP22 PE=1 SV=1 CANONICAL=Q9TQZ3-1" }, "locus": { "chromosome": "19", "start_pos": 32779668, "end_pos": 32763770, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115275.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115275.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088986.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088986.1" } ] } }, { "isoform_ac": "A0AAA9TIX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TIX3/entry", "sequence": { "sequence": "MLLLLLGIIVLHVAVLVLLFVSTIVSQWMVGNGHATDLWQNCSTSLMGSVQHCFSSSANEWLQSVQATMILSIIFSVLSLFLFFCQLFTLTKGGRFYITGVFQILAGMLTVPVGRDRHAGTCLLCEVPGGGFSCPSHPKGRMVNEAGVGRQACPSETFSPSSGLQTNLGGLRVAERDQAP", "length": 180, "header": "tr|A0AAA9TIX3-1|PMP22_BOVIN Computationally mapped isoform of Peripheral myelin protein 22 OS=Bos taurus OX=9913 GN=PMP22 PE=1 SV=1 CANONICAL=Q9TQZ3-1" }, "locus": { "chromosome": "19", "start_pos": 32779668, "end_pos": 32758019, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125177.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125177.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098403.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098403.1" } ] } }, { "isoform_ac": "Q9TQZ3-1", "url": "https://www.uniprot.org/uniprotkb/Q9TQZ3/entry#Q9TQZ3-1", "sequence": { "sequence": "MLLLLLGIIVLHVAVLVLLFVSTIVSQWMVGNGHATDLWQNCSTSLMGSVQHCFSSSANEWLQSVQATMILSIIFSVLSLFLFFCQLFTLTKGGRFYITGVFQILAGLCVMSAASIYTVRHPEWHFNSDGSYGFAYILAWVAFPLALLSGVIYVILRKRE", "length": 160, "header": "sp|Q9TQZ3-1|PMP22_BOVIN Isoform 1 of Peripheral myelin protein 22 OS=Bos taurus OX=9913 GN=PMP22 PE=1 SV=2 CANONICAL=Q9TQZ3-1" }, "locus": { "chromosome": "19", "start_pos": 32779668, "end_pos": 32756780, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025389.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025389.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025389.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025389.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G25614IV", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "N", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 41, "start_aa": 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(complex) asparagine;Complex", "icn3d_view": {}, "start_pos": 41, "start_aa": "Asn", "end_pos": 41, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn41", "evidence": [ { "id": "Q9TQZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TQZ3#ptm_processing" }, { "id": "10899964", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10899964" } ], "filter_code": "001000000000000000000.10000000000000.00.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Structure of a major oligosaccharide of PASII/PMP22 glycoprotein in bovine peripheral nerve myelin.", "journal": "Journal of neurochemistry", "date": "2000-08", "authors": "Kitamura K, Uyemura K, Shibuya K, Sakamoto Y, Yoshimura K, Nomura M", "evidence": [ { "database": "UniProtKB", "id": "Q9TQZ3", "url": "https://www.uniprot.org/uniprotkb/Q9TQZ3#ptm_processing" }, { "database": "UniProtKB", "id": "Q9TQZ3", "url": "https://www.uniprot.org/uniprotkb/Q9TQZ3" }, { "database": "GlyConnect", "id": "488", "url": "https://glyconnect.expasy.org/browser/proteins/488" } ], "reference": [ { "type": "PubMed", "id": "10899964", "url": "https://glygen.org/publication/PubMed/10899964" } ] }, { "title": "Structure and function of peripheral nerve myelin proteins.", "journal": "Prog. Brain Res.", "date": "1995", "authors": "Uyemura K, Asou H, Takeda Y", "evidence": [ { "database": "UniProtKB", "id": "Q9TQZ3", "url": "https://www.uniprot.org/uniprotkb/Q9TQZ3" } ], "reference": [ { "type": "PubMed", "id": "7568893", "url": "https://glygen.org/publication/PubMed/7568893" } ] } ], "pathway": [ { "id": "bta:534497", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534497", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PDJ2-1", "protein_name": "Peripheral myelin protein 22", "gene_name": "PMP22", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLLLLLGIIVLHVTVLVLLFVSTIVSQWLVNGGQTADLWQNCTSGTGAIFQCLTSSTNEWLQSVQAMMILSVIFSVLSLFLFFCQLFTLTKGGRFYLTGIFQILAGLCVMSGAAIFTVRHTDWHEASENTSYGFAYILAWLAFPLALASGIIYVILRKRE", "length": 160 }, "evidence": [ { "id": "Q9TQZ3", "url": "https://omabrowser.org/oma/group/Q9TQZ3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A480F3W3-1", "protein_name": "Peripheral myelin protein 22", "gene_name": "PMP22", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLLLLLGIIVLHVAVLVLLFVSTIVSQWMVGNGHATDLWQNCTTSPSGNVQHCFMSSANEWLQSVQATMILSVIFSVLSLFLFFCQLFTLTKGGRFYITGVFQILAGLCVMSAASIYTVRHLDWHYGSENSYGFAYILAWVAFPLALLSGVVYVILRKRE", "length": 160 }, "evidence": [ { "id": "Q9TQZ3", "url": "https://omabrowser.org/oma/group/Q9TQZ3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P16646-1", "protein_name": "Peripheral myelin protein 22", "gene_name": "Pmp22", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLLLLGILFLHIAVLVLLFVSTIVSQWLVGNGHTTDLWQNCTTSALGAVQHCYSSSVSEWLQSVQATMILSVIFSVLALFLFFCQLFTLTKGGRFYITGFFQILAGLCVMSAAAIYTVRHSEWHVNTDYSYGFAYILAWVAFPLALLSGIIYVILRKREL", "length": 161 }, "evidence": [ { "id": "Q9TQZ3", "url": "https://omabrowser.org/oma/group/Q9TQZ3/", "database": "OMA" } ], "glygen_name": 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"title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q95MI6-1", "uniprot_ac": "Q95MI6", "uniprot_id": "CRH_BOVIN", "mass": { "chemical_mass": 20777.0, "monoisotopic_mass": 20777.0 }, "refseq": { "ac": "NP_001013418", "name": "corticoliberin precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013418" }, "gene_names": [ { "name": "CRH", "type": "recommended", "evidence": [ { "id": "Q95MI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95MI6" } ] }, { "name": "CRF", "type": "synonym", "evidence": [ { "id": "NP_001013418", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013418" } ] }, { "name": "CRH", "type": "synonym", "evidence": [ { "id": "NP_001013418", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013418" } ] } ], "protein_names": [ { "name": "Corticotropin-releasing hormone", "type": "recommended", "evidence": [ { "id": 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"https://www.ncbi.nlm.nih.gov/protein/NP_001013418" } ] }, { "name": "corticotropin-releasing factor", "type": "synonym", "evidence": [ { "id": "NP_001013418", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013418" } ] } ], "function": [ { "annotation": "CRH is a promising candidate gene for a concordant QTL related to lipid metabolism in mammals.", "evidence": [ { "database": "RefSeq", "id": "NP_001013418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013418" }, { "database": "PubMed", "id": "18059556", "url": "https://glygen.org/publication/PubMed/18059556" } ] }, { "annotation": "Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile.", "evidence": [ { "database": "UniProtKB", "id": "A0AAF6ZGI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGI3#function" }, { "database": "UniProtKB", "id": "ARBA00045779", "url": "https://www.uniprot.org/uniprotkb/ARBA00045779#function" }, { "database": "UniProtKB", "id": "A0AAA9S8N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N2#function" }, { "database": "UniProtKB", "id": "A0AAA9T8A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8A2#function" } ] }, { "annotation": "Hormone that plays a central role in whole body adaptation to stress. Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptor CRHR1, and to a lower extent, CRHR2. CRH-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production. Acts as a 'placental clock' during pregnancy, regulating gestational length, fetal development and the timing of labor. Also acts as a regulator of blastocyst implantation by promoting decidualization, regulating trophoblast invasion and facilitating maternal immune tolerance.", "evidence": [ { "database": "UniProtKB", "id": "Q95MI6", "url": "https://www.uniprot.org/uniprotkb/Q95MI6#function" }, { "database": "UniProtKB", "id": "P06850", "url": "https://www.uniprot.org/uniprotkb/P06850#function" } ] }, { "annotation": "Relationship between polymorphism in the CRH gene and the traits of body conformation of Salers cows.", "evidence": [ { "database": "RefSeq", "id": "NP_001013418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013418" }, { "database": "PubMed", "id": "31328644", "url": "https://glygen.org/publication/PubMed/31328644" } ] }, { "annotation": "The association has been reported between polymorphisms of the CRH and POMC genes with economic traits in Korean cattle. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001013418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013418" }, { "database": "PubMed", "id": "26400272", "url": "https://glygen.org/publication/PubMed/26400272" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q95MI6", "url": "https://www.uniprot.org/uniprotkb/Q95MI6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CRH", "url": "https://www.uniprot.org/uniprotkb/Q95MI6", "locus": { "chromosome": "14", "start_pos": 30515974, "end_pos": 30598411, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033128", "url": "https://www.ensembl.org/id/ENSBTAG00000033128" } ] } } ], "crossref": [ { "id": "Q95MI6", "url": 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"Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001013418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013418", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8N2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8N2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8A2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8A2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8A2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8A2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGI3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6ZGI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q95MI6", "url": "https://www.uniprot.org/uniprotkb/Q95MI6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q95MI6-1", "url": "https://www.uniprot.org/uniprotkb/Q95MI6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLRLLVSVGVLLVALLPSPPCRALLSRGPIPGARQASQHPQPLSFFQPPPQPQEPQALPTLLRVGEEYFLRLGNLDETRAAPLSPAASPLASRSSSRLSPDKVAANFFRALLQPRRPFDSPAGPAERGTENALGSRQEAPAARKRRSQEPPISLDLTFHLLREVLEMTKADQLAQQAHNNRKLLDIAGK", "length": 190, "header": "sp|Q95MI6-1|CRH_BOVIN Isoform 1 of Corticotropin-releasing hormone OS=Bos taurus OX=9913 GN=CRH PE=2 SV=2 CANONICAL=Q95MI6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8N2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8N2/entry", "sequence": { "sequence": "MSLQSHLLVLHSFPGRKLMGHFVSSRGIFSDAEELPDTAGSGVEKLRAHVRGETEEEEKRKRTEWEEKGEGKRTAEKKAPETFSAEKRCAPLTCRSTSEAPAKMRLRLLVSVGVLLVALLPSPPCRALLSRGPIPGARQASQHPQPLSFFQPPPQPQEPQALPTLLRVGEEYFLRLGNLDETRAAPLSPAASPLASRSSSRLSPDKVAANFFRALLQPRRPFDSPAGPAERGTENALGSRQEAPAARKRRSQEPPISLDLTFHLLREVLEMTKADQLAQQAHNNRKLLDIAGK", "length": 293, "header": "tr|A0AAA9S8N2-1|CRH_BOVIN Computationally mapped isoform of Corticotropin-releasing hormone OS=Bos taurus OX=9913 GN=CRH PE=2 SV=1 CANONICAL=Q95MI6-1" }, "locus": { "chromosome": "14", "start_pos": 30520199, "end_pos": 30518097, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132563.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132563.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081630.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081630.1" } ] } }, { "isoform_ac": "A0AAA9T8A2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8A2/entry", "sequence": { "sequence": "MMGSLSAGRVQSACCCFPSSPGTSCLAHRMRNYTNVFKAHRHGEVGTYFEDLGSGVEKLRAHVRGETEEEEKRKRTEWEEKGEGKRTAEKKAPETFSAEKRCAPLTCRSTSEAPAKMRLRLLVSVGVLLVALLPSPPCRALLSRGPIPGARQASQHPQPLSFFQPPPQPQEPQALPTLLRVGEEYFLRLGNLDETRAAPLSPAASPLASRSSSRLSPDKVAANFFRALLQPRRPFDSPAGPAERGTENALGSRQEAPAARKRRSQEPPISLDLTFHLLREVLEMTKADQLAQQAHNNRKLLDIAGK", "length": 306, "header": "tr|A0AAA9T8A2-1|CRH_BOVIN Computationally mapped isoform of Corticotropin-releasing hormone OS=Bos taurus OX=9913 GN=CRH PE=2 SV=1 CANONICAL=Q95MI6-1" }, "locus": { "chromosome": "14", "start_pos": 30597318, "end_pos": 30518097, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135370.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135370.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092074.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092074.1" } ] } }, { "isoform_ac": "A0AAF6ZGI3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6ZGI3/entry", "sequence": { "sequence": "MHRMRNYTNVFKAHRHGEVGTYFEDLGSGVEKLRAHVRGETEEEEKRKRTEWEEKGEGKRTAEKKAPETFSAEKRCAPLTCRSTSEAPAKMRLRLLVSVGVLLVALLPSPPCRALLSRGPIPGARQASQHPQPLSFFQPPPQPQEPQALPTLLRVGEEYFLRLGNLDETRAAPLSPAASPLASRSSSRLSPDKVAANFFRALLQPRRPFDSPAGPAERGTENALGSRQEAPAARKRRSQEPPISLDLTFHLLREVLEMTKADQLAQQAHNNRKLLDIAGK", "length": 280, "header": "tr|A0AAF6ZGI3-1|CRH_BOVIN Computationally mapped isoform of Corticotropin-releasing hormone OS=Bos taurus OX=9913 GN=CRH PE=2 SV=1 CANONICAL=Q95MI6-1" }, "locus": { "chromosome": "14", "start_pos": 30596380, "end_pos": 30518097, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047063.4", "url": "https://www.ensembl.org/id/ENSBTAT00000047063.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044298.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044298.3" } ] } }, { "isoform_ac": "Q95MI6-1", "url": "https://www.uniprot.org/uniprotkb/Q95MI6/entry#Q95MI6-1", "sequence": { "sequence": "MRLRLLVSVGVLLVALLPSPPCRALLSRGPIPGARQASQHPQPLSFFQPPPQPQEPQALPTLLRVGEEYFLRLGNLDETRAAPLSPAASPLASRSSSRLSPDKVAANFFRALLQPRRPFDSPAGPAERGTENALGSRQEAPAARKRRSQEPPISLDLTFHLLREVLEMTKADQLAQQAHNNRKLLDIAGK", "length": 190, "header": "sp|Q95MI6-1|CRH_BOVIN Isoform 1 of Corticotropin-releasing hormone OS=Bos taurus OX=9913 GN=CRH PE=2 SV=2 CANONICAL=Q95MI6-1" }, "locus": { "chromosome": "14", "start_pos": 30518666, "end_pos": 30518097, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124790.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124790.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087004.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087004.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Single nucleotide polymorphisms in the corticotrophin-releasing hormone and pro-opiomelancortin genes are associated with growth and carcass yield in beef cattle.", "journal": "Anim. Genet.", "date": "2005", "authors": "Buchanan F C, Thue T D, Yu P, Winkelman-Sim D C", "evidence": [ { "database": "UniProtKB", "id": "Q95MI6", "url": "https://www.uniprot.org/uniprotkb/Q95MI6" } ], "reference": [ { "type": "PubMed", "id": "15771721", "url": "https://glygen.org/publication/PubMed/15771721" } ] }, { "title": "Corticotropin releasing hormone is a promising candidate gene for marbling and subcutaneous fat depth in beef cattle.", "journal": "Genome", "date": "2007-10", "authors": "Wibowo Tito A, Michal Jennifer J, Jiang Zhihua", "evidence": [ { "database": "RefSeq", "id": "NP_001013418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013418" } ], "reference": [ { "type": "PubMed", "id": "18059556", "url": "https://glygen.org/publication/PubMed/18059556" } ] }, { "title": "Association between polymorphisms of the CRH and POMC genes with economic traits in Korean cattle (Hanwoo).", "journal": "Genetics and molecular research : GMR", "date": "2015-09-08", "authors": "Seong J, Kong H S", "evidence": [ { "database": "RefSeq", "id": "NP_001013418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013418" } ], "reference": [ { "type": "PubMed", "id": "26400272", "url": "https://glygen.org/publication/PubMed/26400272" } ] }, { "title": "Relationship between polymorphism in the CRH gene and the traits of body conformation of Salers cows.", "journal": "Animal biotechnology", "date": "2021-02", "authors": "Kowalewska-\u0141uczak Inga, Czerniawska-Pi\u0105tkowska Ewa, Kowalczyk Alicja", "evidence": [ { "database": "RefSeq", "id": "NP_001013418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013418" } ], "reference": [ { "type": "PubMed", "id": "31328644", "url": "https://glygen.org/publication/PubMed/31328644" } ] } ], "pathway": [ { "id": "bta:280755", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:280755", "resource": "KEGG Pathway" }, { "id": "R-BTA-373080", "name": "", "url": 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0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q9MZ08-1", "uniprot_ac": "Q9MZ08", "uniprot_id": "BCAM_BOVIN", "mass": { "chemical_mass": 68003.0, "monoisotopic_mass": 68003.0 }, "refseq": { "ac": "NP_777166", "name": "basal cell adhesion molecule precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777166" }, "gene_names": [ { "name": "BCAM", "type": "recommended", "evidence": [ { "id": "Q9MZ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ] }, { "name": "BCAM", "type": "synonym", "evidence": [ { "id": "NP_777166", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777166" } ] }, { "name": "LU", "type": "synonym", "evidence": [ { "id": "NP_777166", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777166" } ] } ], "protein_names": [ { "name": "Basal cell adhesion molecule", "type": "recommended", "evidence": [ { "id": "Q9MZ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08/entry#names_and_taxonomy" } ] }, { "name": "B-CAM cell surface glycoprotein", "type": "synonym", "evidence": [ { "id": "NP_777166", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777166" }, { "id": "Q9MZ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08/entry#names_and_taxonomy" } ] }, { "name": "Lutheran antigen", "type": "synonym", "evidence": [ { "id": "Q9MZ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08/entry#names_and_taxonomy" } ] }, { "name": "Lutheran blood group (Auberger b antigen included)", "type": "synonym", "evidence": [ { "id": "NP_777166", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777166" } ] }, { "name": "basal cell adhesion molecule (Lutheran blood group)", "type": "synonym", "evidence": [ { "id": "NP_777166", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777166" } ] }, { "name": "basal cell adhesion molecule precursor", "type": "synonym", "evidence": [ { "id": "NP_777166", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777166" } ] }, { "name": "lutheran antigen", "type": "synonym", "evidence": [ { "id": "NP_777166", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777166" } ] } ], "function": [ { "annotation": "Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR.", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08#function" }, { "database": "UniProtKB", "id": "P50895", "url": "https://www.uniprot.org/uniprotkb/P50895#function" }, { "database": "UniProtKB", "id": "A0AAA9TGF2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGF2#function" }, { "database": "UniProtKB", "id": "ARBA00057270", "url": "https://www.uniprot.org/uniprotkb/ARBA00057270#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BCAM", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08", "locus": { "chromosome": "18", "start_pos": 52574350, "end_pos": 52563039, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009495", "url": "https://www.ensembl.org/id/ENSBTAG00000009495" } ] } } ], "crossref": [ { "id": "Q9MZ08", "url": "https://alphafold.ebi.ac.uk/entry/Q9MZ08", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009495", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009495", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282862", "url": "https://www.ncbi.nlm.nih.gov/gene/282862", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282862", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282862", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GYMTIRT", "url": "https://omabrowser.org/oma/group/GYMTIRT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q9MZ08", "url": "https://www.orthodb.org/?gene=Q9MZ08", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11973", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11973", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11973:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11973:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_777166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777166", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TGF2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9MZ08-1", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPPDARAGARRAPRLLVLALLLAAPPGSKAEVRLSVPPLVEVMRGESVTLDCSPLGTHDYFMLEWFLVDRSGARHRLASAELRGSELRDKELNSRGRSPPYQLDSQGRLVLPEAQVGDERDYVCVVKAGAAGTAEATARLKVFAKPEAPEVSPNKGILSVMDDFAQEIATCSSRNGNPAPQIMWYRNGQPLAVPLEVNSEGYMTTRTVREASGLLSLTSTLYLRLHKPDREASFHCSVHYYLPAGQHGRLDGPSFSLTLHYPTEHVLFWLGSQSTAEGWVREGDSVQLLCQGDGSPTPEYTFFWLQDKQEDVLKTSLEGNLTLERVQRNQSGTYGCRVEDFDVPEDAELSKTLELRVAYLDSLELSAGEELSLPLHNSTTVTCSARGLPTPTLYWTKDSAPMGEDPTLSLHSVTFDSAGTYTCEAYMPRIPLLSRTRSFRLLVQGTPELKAKETQPKAEGSWTEGDEVTLICYARGYPKPKLTWSQLGGSPTEPAPGGQGWVSSSLTLKVTSALSQDGVSCEASNPLGNTHHVFHFGTVAPQTSQAGVAVMAVAISVALLLLVVAVFYCMRRKGRPGCCQWGEKGSPPPGEPKLSHSGSQRPEQTGLLMGSASGGAKHGSGGFGDEC", "length": 628, "header": "sp|Q9MZ08-1|BCAM_BOVIN Isoform 1 of Basal cell adhesion molecule OS=Bos taurus OX=9913 GN=BCAM PE=2 SV=2 CANONICAL=Q9MZ08-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TGF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGF2/entry", "sequence": { "sequence": "MERPGGQGRATRRLRGTELSHPPAGSKAEVRLSVPPLVEVMRGESVTLDCSPLGTHDYFMLEWFLVDRSGARHRLASAELRGSELRDKELNSRGRSPPYQLDSQGRLVLPEAQVGDERDYVCVVKAGAAGTAEATARLKVFAKPEAPEVSPNKGILSVMDDFAQEIATCSSRNGNPAPQIMWYRNGQPLAVPLEVNSEGYMTTRTVREASGLLSLTSTLYLRLHKPDREASFHCSVHYYLPAGQHGRLDGPSFSLTLHYPTEHVLFWLGSQSTAEGWVREGDSVQLLCQGDGSPTPEYTFFWLQDKQEDVLKTSLEGNLTLERVQRNQSGTYGCRVEDFDVPEDAELSKTLELRVAYLDSLELSAGEELSLPLHNSTTVTCSARGLPTPTLYWTKDSAPMGEDPTLSLHSVTFDSAGTYTCEAYMPRIPLLSRTRSFRLLVQGTPELKAKETQPKAEGSWTEGDEVTLICYARGYPKPKLTWSQLGGSPTEPAPGGQGWVSSSLTLKVTSALSQDGVSCEASNPLGNTHHVFHFGTVAPQTSQAGVAVMAVAISVALLLLVVAVFYCMRRKGRPGCCQWGEKGSPPPGEPKLSHSGSQRPEQTGLLMGSASGGAKHGSGGFGDEVSEGLGPWGEGTTAGGRAAVGPG", "length": 647, "header": "tr|A0AAA9TGF2-1|BCAM_BOVIN Computationally mapped isoform of Basal cell adhesion molecule OS=Bos taurus OX=9913 GN=BCAM PE=2 SV=1 CANONICAL=Q9MZ08-1" }, "locus": { "chromosome": "18", "start_pos": 52573886, "end_pos": 52564383, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131352.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131352.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096122.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096122.1" } ] } }, { "isoform_ac": "Q9MZ08-1", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08/entry#Q9MZ08-1", "sequence": { "sequence": "MEPPDARAGARRAPRLLVLALLLAAPPGSKAEVRLSVPPLVEVMRGESVTLDCSPLGTHDYFMLEWFLVDRSGARHRLASAELRGSELRDKELNSRGRSPPYQLDSQGRLVLPEAQVGDERDYVCVVKAGAAGTAEATARLKVFAKPEAPEVSPNKGILSVMDDFAQEIATCSSRNGNPAPQIMWYRNGQPLAVPLEVNSEGYMTTRTVREASGLLSLTSTLYLRLHKPDREASFHCSVHYYLPAGQHGRLDGPSFSLTLHYPTEHVLFWLGSQSTAEGWVREGDSVQLLCQGDGSPTPEYTFFWLQDKQEDVLKTSLEGNLTLERVQRNQSGTYGCRVEDFDVPEDAELSKTLELRVAYLDSLELSAGEELSLPLHNSTTVTCSARGLPTPTLYWTKDSAPMGEDPTLSLHSVTFDSAGTYTCEAYMPRIPLLSRTRSFRLLVQGTPELKAKETQPKAEGSWTEGDEVTLICYARGYPKPKLTWSQLGGSPTEPAPGGQGWVSSSLTLKVTSALSQDGVSCEASNPLGNTHHVFHFGTVAPQTSQAGVAVMAVAISVALLLLVVAVFYCMRRKGRPGCCQWGEKGSPPPGEPKLSHSGSQRPEQTGLLMGSASGGAKHGSGGFGDEC", "length": 628, "header": "sp|Q9MZ08-1|BCAM_BOVIN Isoform 1 of Basal cell adhesion molecule OS=Bos taurus OX=9913 GN=BCAM PE=2 SV=2 CANONICAL=Q9MZ08-1" }, "locus": { "chromosome": "18", "start_pos": 52573912, "end_pos": 52563078, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012495.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012495.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012495.3", "url": "https://www.ensembl.org/id/ENSBTAP00000012495.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 298, "start_aa": "Thr", "end_pos": 298, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr298", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 321, "start_aa": "Asn", "end_pos": 321, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn321", "evidence": [ { "id": "Q9MZ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08#ptm_processing" } ], "filter_code": "001000000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 330, "start_aa": "Asn", "end_pos": 330, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn330", "evidence": [ { "id": "Q9MZ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08#ptm_processing" } ], "filter_code": "001000000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 378, "start_aa": "Asn", "end_pos": 378, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn378", "evidence": [ { "id": "Q9MZ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08#ptm_processing" } ], "filter_code": "001000000000000000000.00010000000000.0.01000" } ], "phosphorylation": [ { "start_pos": 596, "end_pos": 596, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "site_lbl": "Ser596" }, { "start_pos": 598, "end_pos": 598, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "site_lbl": "Ser598" }, { "start_pos": 600, "end_pos": 600, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "site_lbl": "Ser600" }, { "start_pos": 621, "end_pos": 621, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "site_lbl": "Ser621" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Selective Lutheran glycoprotein gene expression at the blood-brain barrier in normal brain and in human brain tumors.", "journal": "J. Cereb. Blood Flow Metab.", "date": "2000", "authors": "Boado R J, Li J Y, Pardridge W M", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "reference": [ { "type": "PubMed", "id": "10908043", "url": "https://glygen.org/publication/PubMed/10908043" } ] }, { "title": "Vascular proteomics and subtractive antibody expression cloning.", "journal": "Mol. Cell. Proteomics", "date": "2002", "authors": "Shusta Eric V, Boado Ruben J, Pardridge William M", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "reference": [ { "type": "PubMed", "id": "12096143", "url": "https://glygen.org/publication/PubMed/12096143" } ] } ], "pathway": [ { "id": "bta:282862", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282862", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QRV6-1", "protein_name": "Basal cell adhesion molecule", "gene_name": "BCAM", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPPDARAPRLLVLALLLGAHPGAEAEVRLSVPPLVEVMRGEPVTLDCTPLGTHDHFVLEWFLADRTGVRHRLASAELQGSELQDKMHDSWGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDIAQEIATCNSRNGNPVPQITWYRNGQRLEVPLEVNSEGYMTSRTVREASGLLSLTSTLYLRLRKADRDASFHCSVHYRLPTGRHGRLDSPAFRLTLHYPTEHVQFWLGSPSTTAGWVREGDSVQLFCRGDGSPTPEYTFFRLQDQEEDVLKTNLEGNLTLEGVQRSQSGTYGCRVEDYDAAEDAELSKTLELHVAYLDPLELSTGEELSLPLGNSTAVNCSVRGLPTPTLRWTKDSVPLGDDSTLSLRSITFDSAGTYTCEASMPTVPLLSRTRSFKLLVQGPPELRAEEVQPKAEGSWREGDEVKLICRTRGYPEPKLSWSQLGGSPAEPAPGGQGWVSSSLTLKVTSALSRDGVSCEASNPHGNDRHVFHFGTVAPQTSQAGVAVMAVAVSVGLLLLVVAAFYCMRRKGHRCCRQGEKGSPLPGEPELSHSGSEGPEQTGLLMGGASGGAKHGSGGFGDEC", "length": 622 }, "evidence": [ { "id": "Q9MZ08", "url": "https://omabrowser.org/oma/group/Q9MZ08/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P50895-1", "protein_name": "Basal cell adhesion molecule", "gene_name": "BCAM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPPDAPAQARGAPRLLLLAVLLAAHPDAQAEVRLSVPPLVEVMRGKSVILDCTPTGTHDHYMLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGRLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQEIATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHYPTEHVQFWVGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTPLGDGPMLSLSSITFDSNGTYVCEASLPTVPVLSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVAVMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKGAPPPGEPGLSHSGSEQPEQTGLLMGGASGGARGGSGGFGDEC", "length": 628 }, "evidence": [ { "id": "Q9MZ08", "url": "https://omabrowser.org/oma/group/Q9MZ08/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ESS6-1", "protein_name": "Basal cell adhesion molecule", "gene_name": "Bcam", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPPDARAGLLWLTLLLSGYSGAQAELHVSVPPRVEVMRGEQIALDCTPREHPENYVLEWLLVDASGARHRLASVEPQGSEFLGTIHNSRGRRPPYKIDSLGRLVIAEAQVGDERDYVCVVKAGAAGTSEATSSVRVFATPEATEVAPNKGTLSVMEQFAQEIATCSSNNGNPVPRITWYQNGQRLDVPMELNSKGYMTSRTVREASGLYSLTSTLYLRLHKEDRDASFHCAAHYDLPSGQHGRLDSHTFRLTLHYPTEHVEFWVGSPSTTEGWVREGDAVQLLCQGDGSPSPEYSFFREQGNQEEQLNVNLKGNLTLEGVHRSQSGIYGCRVEDYDADEEVQLVKKLKLHVAYLDPLELSVPEEFSVFLNSSGTVVNCSARGLPAPIVRWTKDSVTVADGPILSLDSVTFDSAGTYTCEASTPTVPLLSRTQSFQLVVQGAPELKPNEIKPKSGTSWTEGDEVMLTCSARGFPEPKLTWSQRGDTTPAEPPFEGRGWMSSSLTLKVTSALSREGVSCEASNIHGKNGHVFHFGSVAPQTAQAGVAVMAVAVSVGLLLLVVAAFYCMRRKGRPGCCQRAEKGAPPAREPELSHSGSERPEHTGLLMGGPSGGGRGGNGGFGDEC", "length": 624 }, "evidence": [ { "id": "Q9MZ08", "url": "https://omabrowser.org/oma/group/Q9MZ08/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9R069-1", "protein_name": "Basal cell adhesion molecule", "gene_name": "Bcam", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPPDARAGLLWLTFLLSGYSGAQAELHVSVPPRVEVMRGEQVALDCTPREHPEHYVLEWFLVDGTGARHRLASVEPQGSEFLGTVHSLGRVPPYEVDSRGRLVIAKVQVGDGRDYVCVVKAGAAGTSEATSSVRVFATPEDTEVSPNKGTLSVMDQFAQEIATCSSNNGNPVPRITWYRNGQRLEVPMEVNQKGYITIRTVREASGLYSLTSTLYLRLHKDDRDANFHCAAHYDLPSGQHGRLDSHTFRLTLHYPTEHVEFWVGSPSTTEGWVREGDAVQLLCQGDGSPSPEYSFFRQQGTQEEQLNVNLKGNLTLERVHRNQSGIYGCRVEDYDADEEVQLVKKLKLHVAYLDPLELSVPEELFVFLNSSSTVVNCSARGLPTPTVRWTKDSVTLADGPMLSLQSVTFDSAGTYTCEASTPTVPLLSRTQSFQLIVQGAPELKPNEIMPKSGNSWTEGDEVMLTCSARGFPEPKLTWSQRGDTPAEPPFEGRGWKSSSLMVKVTSALSREGVSCEASNIHGKKGHVFHFGSVAPQTAQAGVAVMAVAVSVGLLLLVVAAFYCMRRKGRPGCCRRAEKGAPPAREPELSHSGSERPEHTGLLMGGPSGGGRGGSGGFGDEC", "length": 622 }, "evidence": [ { "id": "Q9MZ08", "url": "https://omabrowser.org/oma/group/Q9MZ08/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "pmid": "" }, { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "laminin receptor activity", "id": "GO:0005055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005055", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "pmid": "" }, { "name": "laminin binding", "id": "GO:0043236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043236", "evidence": [ { "database": "UniProtKB", "id": "Q9MZ08", "url": "https://www.uniprot.org/uniprotkb/Q9MZ08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 330, "end_pos": 332, "annotation": "n_glycosylation_sequon" }, { "start_pos": 378, "end_pos": 380, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9MZ08-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 628, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9MZ08-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9MZ08" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 321, 330, 378 ], "o_linked_sites": [ 298 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 596, 598, 600, 621 ], "sequon_annotation_sites": [ { "start_pos": 321, "end_pos": 323 }, { "start_pos": 330, "end_pos": 332 }, { "start_pos": 378, "end_pos": 380 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q9BE45-1", "uniprot_ac": "Q9BE45", "uniprot_id": "IKBZ_BOVIN", "mass": { "chemical_mass": 78239.0, "monoisotopic_mass": 78239.0 }, "refseq": { "ac": "NP_777151", "name": "NF-kappa-B inhibitor zeta", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777151" }, "gene_names": [ { "name": "NFKBIZ", "type": "recommended", "evidence": [ { "id": "Q9BE45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ] }, { "name": "MAIL", "type": "synonym", "evidence": [ { "id": "NP_777151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777151" }, { "id": "Q9BE45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ] }, { "name": "NFKBIZ", "type": "synonym", "evidence": [ { "id": "NP_777151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777151" } ] } ], "protein_names": [ { "name": "NF-kappa-B inhibitor zeta", "type": "recommended", "evidence": [ { "id": "Q9BE45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BE45/entry#names_and_taxonomy" } ] }, { "name": "I-kappa-B-zeta", "type": "synonym", "evidence": [ { "id": "NP_777151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777151" }, { "id": "Q9BE45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BE45/entry#names_and_taxonomy" } ] }, { "name": "IkB-zeta", "type": "synonym", "evidence": [ { "id": "Q9BE45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BE45/entry#names_and_taxonomy" } ] }, { "name": "IkappaBzeta", "type": "synonym", "evidence": [ { "id": "Q9BE45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BE45/entry#names_and_taxonomy" } ] }, { "name": "MAIL", "type": "synonym", "evidence": [ { "id": "Q9BE45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BE45/entry#names_and_taxonomy" } ] }, { "name": "Molecule possessing ankyrin repeats induced by lipopolysaccharide", "type": "synonym", "evidence": [ { "id": "Q9BE45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BE45/entry#names_and_taxonomy" } ] }, { "name": "NF-kappa-B inhibitor zeta", "type": "synonym", "evidence": [ { "id": "NP_777151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777151" } ] }, { "name": "ikB-zeta", "type": "synonym", "evidence": [ { "id": "NP_777151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777151" } ] }, { "name": "ikappaBzeta", "type": "synonym", "evidence": [ { "id": "NP_777151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777151" } ] }, { "name": "molecule possessing ankyrin-repeats induced by lipopolysaccharide", "type": "synonym", "evidence": [ { "id": "NP_777151", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777151" } ] } ], "function": [ { "annotation": "Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Also seems to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TSY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSY6#function" }, { "database": "UniProtKB", "id": "ARBA00094480", "url": "https://www.uniprot.org/uniprotkb/ARBA00094480#function" }, { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45#function" }, { "database": "UniProtKB", "id": "Q9EST8", "url": "https://www.uniprot.org/uniprotkb/Q9EST8#function" }, { "database": "UniProtKB", "id": "Q9BYH8", "url": "https://www.uniprot.org/uniprotkb/Q9BYH8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NFKBIZ", "url": "https://www.uniprot.org/uniprotkb/Q9BE45", "locus": { "chromosome": "1", "start_pos": 46201247, "end_pos": 46190140, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010987", "url": "https://www.ensembl.org/id/ENSBTAG00000010987" } ] } } ], "crossref": [ { "id": "Q9BE45", "url": "https://alphafold.ebi.ac.uk/entry/Q9BE45", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010987", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010987", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "282713", "url": "https://www.ncbi.nlm.nih.gov/gene/282713", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282713", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282713", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QFSWMSP", "url": "https://omabrowser.org/oma/group/QFSWMSP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q9BE45", "url": "https://www.orthodb.org/?gene=Q9BE45", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24124", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24124", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24124:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24124:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_777151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777151", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TSY6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TSY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSY6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9BE45-1", "url": "https://www.uniprot.org/uniprotkb/Q9BE45-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIVDKLLDDSRGGEGLLDAAGDCGLMTSPLNLAYFYGASPPAAAPGACDGGCSASGPSAPGSPGSDSSDFSSASSVSSCGAVESRPRGGARAERLQVEPHMGVVRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQSVNREQFTELKNTVSYSGKRKGSDSLSDGPACKRSALLHTQFLTPPQTPTPAESMEDVHHNESKQDSCADLLQNIINIKNECSPVSLNTVQVSWMSPGEVPQGSPHEQCQDLHRGQVFSPPQKYQPFQVSSSPHMMDQASMYQYSPQNQSVQPPPQHYTHNPALEYSPYSRTSQSPSYEPHLFGREPQFCPDQSFAPLLSDPRQSENIAVPPQTAPSVQQQIDTHLQNFSLMPPDTCEALARPDASSTPLSTPLPFPNLGGNPMSTTQLGKSFFQWQVEQEENKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVTLGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAAGSNQFVDLEATNYDGLTPLHCAVLAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRVTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY", "length": 719, "header": "sp|Q9BE45-1|IKBZ_BOVIN Isoform 1 of NF-kappa-B inhibitor zeta OS=Bos taurus OX=9913 GN=NFKBIZ PE=2 SV=2 CANONICAL=Q9BE45-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TSY6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TSY6/entry", "sequence": { "sequence": "MIVDKLLDDSRGGEGLLDAAGDCGLMTSPLNLAYFYGASPPAAAPGACDGGCSASGPSAPGSPGSDSSDFSSASSVSSCGAVESRPRGGARAERLQVEPHMGVVRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQSVNREQFTELKNTVSYSGKRKGSDSLSDGPACKRSALLHTQFLTPPQTPTPAESMEDVHHNESKQDSCADLLQNIINIKNECSPVSLNTVQTAPSVQQQIDTHLQNFSLMPPDTCEALARPDASSTPLSTPLPFPNLGGNPMSTTQLGKSFFQWQVEQEENKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVTLGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAAGSNQFVDLEATNYDGLTPLHCAVLAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRVTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY", "length": 597, "header": "tr|A0AAA9TSY6-1|IKBZ_BOVIN Computationally mapped isoform of NF-kappa-B inhibitor zeta OS=Bos taurus OX=9913 GN=NFKBIZ PE=2 SV=1 CANONICAL=Q9BE45-1" }, "locus": { "chromosome": "1", "start_pos": 46199917, "end_pos": 46190254, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124656.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124656.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101488.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101488.1" } ] } }, { "isoform_ac": "Q9BE45-1", "url": "https://www.uniprot.org/uniprotkb/Q9BE45/entry#Q9BE45-1", "sequence": { "sequence": "MIVDKLLDDSRGGEGLLDAAGDCGLMTSPLNLAYFYGASPPAAAPGACDGGCSASGPSAPGSPGSDSSDFSSASSVSSCGAVESRPRGGARAERLQVEPHMGVVRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQSVNREQFTELKNTVSYSGKRKGSDSLSDGPACKRSALLHTQFLTPPQTPTPAESMEDVHHNESKQDSCADLLQNIINIKNECSPVSLNTVQVSWMSPGEVPQGSPHEQCQDLHRGQVFSPPQKYQPFQVSSSPHMMDQASMYQYSPQNQSVQPPPQHYTHNPALEYSPYSRTSQSPSYEPHLFGREPQFCPDQSFAPLLSDPRQSENIAVPPQTAPSVQQQIDTHLQNFSLMPPDTCEALARPDASSTPLSTPLPFPNLGGNPMSTTQLGKSFFQWQVEQEENKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVTLGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAAGSNQFVDLEATNYDGLTPLHCAVLAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRVTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY", "length": 719, "header": "sp|Q9BE45-1|IKBZ_BOVIN Isoform 1 of NF-kappa-B inhibitor zeta OS=Bos taurus OX=9913 GN=NFKBIZ PE=2 SV=2 CANONICAL=Q9BE45-1" }, "locus": { "chromosome": "1", "start_pos": 46199917, "end_pos": 46190254, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014591.7", "url": "https://www.ensembl.org/id/ENSBTAT00000014591.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014591.4", "url": "https://www.ensembl.org/id/ENSBTAP00000014591.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 195, "start_aa": "Thr", "end_pos": 195, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr195", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Cloning of bovine MAIL and its mRNA expression in white blood cells of Holstein cows.", "journal": "Vet. Immunol. Immunopathol.", "date": "2004", "authors": "Yamaji Daisuke, Kitamura Hiroshi, Kimura Kazuhiro, Matsushita Yukiko, Okada Hiroyuki, Shiina Takahiko, Morimatsu Masami, Saito Masayuki", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "reference": [ { "type": "PubMed", "id": "15010226", "url": "https://glygen.org/publication/PubMed/15010226" } ] } ], "pathway": [ { "id": "bta:282713", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282713", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K6U7-1", "protein_name": "NF-kappa-B inhibitor zeta", "gene_name": "Nfkbiz", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIVDKLLDDSRGGEGLLDAAGDCGLMTSPLNLAYFYGASPPSAPGAGDTGYLSAVPSAPGSPGSDSSDFSSTSSVSSCGAVESRPRGGARAERPQVEPHMGVGRQQRGPFQGVRVKNSVKELLLHIRSNKQKTSGQAVDEFKTQSVNIEQLTDLKSAVSAVGKRKGPDPLADGPVCKRPALLPTHFVTSPQTSPRGESMEDARHSESKLESSAALLQNIINIKNECNPVSLNTVQVSWMSPVVPQNSPRDQRQDFHGGQSFSPPQKYQPFQVGGSPQMMEQASMFQYSPQGQNMQQPQPLPPQQQQQQQQQQQQQQQQQQQQQQNYPHNPPLQFSPYSRISQSPKYDSNLFDNQDSQFCTSQSFVSLLTGQGESETMAVPVQASHSVPPQNETQLQNFSLMPSSACEAVGAHDAGSHSLGGSLSLQNIMGGPMNTTQLGKSFFQWQVEQEESKLANISQEQFLSRDGDGDTFLHIAVAQGRRALSYVLARKMNALHMLDVKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVRSNQFVDLEATNYDGLTPLHCAVLAHNSVVHDLQRSQQPHSPEVQDLLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRVTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRVPPY", "length": 743 }, "evidence": [ { "id": "Q9BE45", "url": "https://omabrowser.org/oma/group/Q9BE45/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XX68-1", "protein_name": "NF-kappa-B inhibitor zeta", "gene_name": "NFKBIZ", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MIVDSSRDAAPDGDGGALSSPINLAYFYGASPHSSEGSCSPAHSAPGSPGSDSDLSVSSRGGGRRDGRGGARPALQAEQHMGGGKQHRGPFQGVRVKNSVKELLLHFRSSKQMSSGPAADEGKAQGGLVNYEPYTAELKSVLGQGGKRKAPELLSDGPPFKRQVNVHPHLLTPPQTPTSMDNMEETHKNEPKHESNSDLLQNIINIKNESSPVSLNTVQVSWLHGVSSHSSPGEQYHDSPGTQAFSPPQKYQAFQDHTSQSMLDPPQHYQFPSSQNQDLLQNYTSDASLEYRPFSANDQSPGYHQHAFESHELQYCPSQSFSSLLNDSEGSETISAPLQSLPSAHPQANVSPHAQNFSLAPNNACSSLERSISLATLNVSLPSQSVARNTTQLGKSFFQWQVEQEENKLANISQDQFLAKDSDGDTFLHIAVAQGRRALSYVLARKMAALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVSLGAQVNTTDCWGRTPLHVCAEKGHAQVLQAIQKGAMGSNQYVDLEATNYDGLTALHCAVLAHNAVLHELQNCQPPHSPEVQELLLRNKSLVETIKTLIQMGASVEAKDRKSGRSALHLAAEEANLELIRLFLELPNCLSFVNAKAYNGNTALHVAASLQYRVSQLDAVRLLMRKGADPSARNLENEQPVHLVPDGLVGEQIRRILKGKTVQQRASLF", "length": 698 }, "evidence": [ { "id": "Q9BE45", "url": "https://omabrowser.org/oma/group/Q9BE45/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SL19-1", "protein_name": "NF-kappa-B inhibitor zeta", "gene_name": "NFKBIZ", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIVDKLLDDSRGGEGLLDAAGDCGLMTSPLNLAYFYSASPPAAAAPGACDASCSSSGPSAPGSPGSDSSDFSSASSVSSCGAVESRPRGGARAERLQAEPHMGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQTIDDFKTQGVNREQFTELKNTVSYTGKRKGPDSLSDGPACKRSALLHTQFLTPPQTPTPAESMEDVHHNESKQDSSADLLQNIINIKNECSPVSLNTVQVSWMSPVGVPQGSPHEQCQDFHGGQVFSPPQKYQPFQVSGSPHMMDQASMYQYSPQNQNVQPQPLPPPPHYTHNSALEYSPYSRTSLSPTYEPNIFDSQESQYCLNQSFASLLNDPRESENTAVPPQTSPSVQQQTDAHVQNFNLMSHQACEALVHDAGPAPLSTSRQLQDIVGNEMSTTQLGKSFFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVRSNQFVDLEATNYDGLTPLHCAVMAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKGLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRVTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY", "length": 724 }, "evidence": [ { "id": "Q9BE45", "url": "https://omabrowser.org/oma/group/Q9BE45/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9BYH8-1", "protein_name": "NF-kappa-B inhibitor zeta", "gene_name": "NFKBIZ", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVLGPSAPGSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQPVEPHMGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVSYSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNIINIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY", "length": 718 }, "evidence": [ { "id": "Q9BE45", "url": "https://omabrowser.org/oma/group/Q9BE45/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9EST8-1", "protein_name": "NF-kappa-B inhibitor zeta", "gene_name": "Nfkbiz", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIVDKLLDDSRGGEGLLDAAGDCGLMTSPLNLAYFYGASPPSAPGAGDTGYLSAVPSAPGSPGSDSSDFSSTSSVSSCGAVESRPRGGARAERPQVEPHMGVGRQQRGPFQGVRVKNSVKELLLHIRSNKQKASGQPVDEFKTQSVNIEQLTDLKSAVSAVGKRKGPDPLSDGPVCKRPALLPSHFVTSPQTPTPGESMEDVRHSESKLDSSAALLQNIINIKNECNPVSLNTVQVSWMSPTVPQNSPRDQCQDFHGGQAFSPPQKYQPFQVSGSPQMMDQASMYQYSPQTQNMQQPPPLPPQQQHQQNYPHNSPLQFSPYSRMSQSPKYDSNLFDTHEPQFCTGQSFVSLLTGPGEPESLAVPVPAPTSIPPQTETQLQTFSLMPSNACEAVVGVHDVGSHSLGTSLSLQNIMGSPMNTTQLGKSFFQWQVEQEESKLANIPQDQFLARDGDGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVRSNQFVDLEATNYDGLTPLHCAVVAHNAVVHELQRNRQSHSPEVQDLLLRNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRVTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY", "length": 728 }, "evidence": [ { "id": "Q9BE45", "url": "https://omabrowser.org/oma/group/Q9BE45/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 44, "go_terms": [ { "name": "T-helper 1 cell differentiation", "id": "GO:0045063", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045063", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "keratinocyte activation", "id": "GO:0032980", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032980", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "positive regulation of T-helper 17 cell differentiation", "id": "GO:2000321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000321", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "monocyte activation", "id": "GO:0042117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042117", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "defense response to Gram-negative bacterium", "id": "GO:0050829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050829", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "establishment of skin barrier", "id": "GO:0061436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061436", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "keratinocyte differentiation", "id": "GO:0030216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030216", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "homeostasis of number of cells within a tissue", "id": "GO:0048873", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048873", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "cellular response to lipopolysaccharide", "id": "GO:0071222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "spleen development", "id": "GO:0048536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048536", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "positive regulation of inflammatory response", "id": "GO:0050729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050729", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "execution phase of apoptosis", "id": "GO:0097194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097194", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "cellular response to transforming growth factor beta stimulus", "id": "GO:0071560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071560", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "protein secretion", "id": "GO:0009306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009306", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "Q9BE45", "url": "https://www.uniprot.org/uniprotkb/Q9BE45" } ], "pmid": "" }, 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Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_776891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776891" }, { "database": "PubMed", "id": "24141248", "url": "https://glygen.org/publication/PubMed/24141248" } ] }, { "annotation": "Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.", "evidence": [ { "database": "RefSeq", "id": "NP_776891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776891" }, { "database": "PubMed", "id": "16111147", "url": "https://glygen.org/publication/PubMed/16111147" } ] }, { "annotation": "SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. 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"MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSTVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPAAGAPSFSQPPAEPSSSPSSEVPEQPPAQPLSGNPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL", "length": 229, "header": "sp|Q9BEG9-1|SOCS3_BOVIN Isoform 1 of Suppressor of cytokine signaling 3 OS=Bos taurus OX=9913 GN=SOCS3 PE=2 SV=1 CANONICAL=Q9BEG9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6YSP9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YSP9/entry", "sequence": { "sequence": "MEAGDPRFPEYPGWGLSASRVPSLPAPNPPPHASNFFLRPCPPGATGLSGAQSVPGALLPLPTPATLLETQLPRPSFPLGTLPVRAGERAAWRRGLGGLRGASGSERGPSPPGCGSGRCAEAAEQLQPPPPRRSTLAPCAMVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSTVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPAAGAPSFSQPPAEPSSSPSSEVPEQPPAQPLSGNPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL", "length": 369, "header": "tr|A0AAF6YSP9-1|SOCS3_BOVIN Computationally mapped isoform of Suppressor of cytokine signaling 3 OS=Bos taurus OX=9913 GN=SOCS3 PE=2 SV=1 CANONICAL=Q9BEG9-1" }, "locus": { "chromosome": "19", "start_pos": 53840855, "end_pos": 53839630, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000011106.4", "url": "https://www.ensembl.org/id/ENSBTAT00000011106.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000011106.3", "url": "https://www.ensembl.org/id/ENSBTAP00000011106.3" } ] } }, { "isoform_ac": "Q9BEG9-1", "url": "https://www.uniprot.org/uniprotkb/Q9BEG9/entry#Q9BEG9-1", "sequence": { "sequence": "MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSTVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPAAGAPSFSQPPAEPSSSPSSEVPEQPPAQPLSGNPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL", "length": 229, "header": "sp|Q9BEG9-1|SOCS3_BOVIN Isoform 1 of Suppressor of cytokine signaling 3 OS=Bos taurus OX=9913 GN=SOCS3 PE=2 SV=1 CANONICAL=Q9BEG9-1" }, "locus": { "chromosome": "19", "start_pos": 53840855, "end_pos": 53840169, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092959.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092959.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097611.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097611.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Expression of interleukin-10 and suppressor of cytokine signaling-3 associated with susceptibility of cattle to infection with Mycobacterium avium subsp paratuberculosis.", "journal": "American journal of veterinary research", "date": "2005-07", "authors": "Weiss Douglas J, Evanson Oral A, Souza Cleverson D", "evidence": [ { "database": "RefSeq", "id": "NP_776891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776891" } ], "reference": [ { "type": "PubMed", "id": "16111147", "url": "https://glygen.org/publication/PubMed/16111147" } ] }, { "title": "SOCS3-mediated blockade reveals major contribution of JAK2/STAT5 signaling pathway to lactation and proliferation of dairy cow mammary epithelial cells in vitro.", "journal": "Molecules (Basel, Switzerland)", "date": "2013-10-17", "authors": "Huang Yu-Ling, Zhao Feng, Luo Chao-Chao, Zhang Xia, Si Yu, Sun Zhe, Zhang Li, Li Qing-Zhang, Gao Xue-Jun", "evidence": [ { "database": "RefSeq", "id": "NP_776891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776891" } ], "reference": [ { "type": "PubMed", "id": "24141248", "url": "https://glygen.org/publication/PubMed/24141248" } ] }, { "title": "LPS-induced SOCS3 antagonizes the JAK2-STAT5 pathway and inhibits \u03b2-casein synthesis in bovine mammary epithelial cells.", "journal": "Life sciences", "date": "2021-08-01", "authors": "Geng Zijian, Shan Xufei, Lian Shuai, Wang Jianfa, Wu Rui", "evidence": [ { "database": "RefSeq", "id": "NP_776891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776891" } ], "reference": [ { "type": "PubMed", "id": "33930363", "url": "https://glygen.org/publication/PubMed/33930363" } ] } ], "pathway": [ { "id": "bta:282081", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282081", "resource": "KEGG Pathway" }, { "id": "R-BTA-1059683", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1059683", "resource": "Reactome", "description": "Interleukin-6 signaling" }, { "id": "R-BTA-877300", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-877300", "resource": "Reactome", "description": "Interferon gamma signaling" }, { "id": "R-BTA-877312", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-877312", "resource": "Reactome", "description": "Regulation of IFNG signaling" }, { "id": "R-BTA-8849474", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8849474", "resource": "Reactome", "description": "PTK6 Activates STAT3" }, { "id": "R-BTA-8951664", "name": "", "url": 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"count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q9TTF3-1", "uniprot_ac": "Q9TTF3", "uniprot_id": "ZNT4_BOVIN", "mass": { "chemical_mass": 47389.0, "monoisotopic_mass": 47389.0 }, "refseq": { "ac": "XP_002690986", "name": "probable proton-coupled zinc antiporter SLC30A4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690986" }, "gene_names": [ { "name": "SLC30A4", "type": "recommended", "evidence": [ { "id": "Q9TTF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3" } ] }, { "name": "SLC30A4", "type": "synonym", "evidence": [ { "id": "XP_002690986", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690986" } ] } ], "protein_names": [ { "name": "Probable proton-coupled zinc antiporter SLC30A4", "type": "recommended", "evidence": [ { "id": "Q9TTF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 30 member 4", "type": "synonym", "evidence": [ { "id": "Q9TTF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3/entry#names_and_taxonomy" } ] }, { "name": "Zinc transporter 4", "type": "synonym", "evidence": [ { "id": "Q9TTF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3/entry#names_and_taxonomy" } ] }, { "name": "ZnT-4", "type": "synonym", "evidence": [ { "id": "Q9TTF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3/entry#names_and_taxonomy" } ] }, { "name": "probable proton-coupled zinc antiporter SLC30A4", "type": "synonym", "evidence": [ { "id": "XP_002690986", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690986" } ] } ], "function": [ { "annotation": "Probable proton-coupled zinc ion antiporter mediating zinc import from cytoplasm potentially into the endocytic compartment (By similarity). Controls zinc deposition in milk (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9TTF3", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3#function" }, { "database": "UniProtKB", "id": "O14863", "url": "https://www.uniprot.org/uniprotkb/O14863#function" }, { "database": "UniProtKB", "id": "O35149", "url": "https://www.uniprot.org/uniprotkb/O35149#function" }, { "database": "UniProtKB", "id": "F1N7C9", "url": "https://www.uniprot.org/uniprotkb/F1N7C9#function" }, { "database": "UniProtKB", "id": "ARBA00059459", "url": "https://www.uniprot.org/uniprotkb/ARBA00059459#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9TTF3", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC30A4", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3", "locus": { "chromosome": "10", "start_pos": 64974981, "end_pos": 64941762, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021019", "url": "https://www.ensembl.org/id/ENSBTAG00000021019" } ] } } ], "crossref": [ { "id": "Q9TTF3", "url": "https://alphafold.ebi.ac.uk/entry/Q9TTF3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021019", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021019", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540869", "url": "https://www.ncbi.nlm.nih.gov/gene/540869", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002524", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002524", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027469", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027469", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027470", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027470", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050681", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050681", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058533", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058533", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540869", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540869", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PCDNCNK", "url": "https://omabrowser.org/oma/group/PCDNCNK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1N7C9", "url": "https://www.orthodb.org/?gene=F1N7C9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q9TTF3", "url": "https://www.orthodb.org/?gene=Q9TTF3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11562", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11562:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01545", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01545", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16916", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16916", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002690986", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690986", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "72627", "url": "https://www.rhea-db.org/rhea/72627", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1N7C9", "url": "https://www.uniprot.org/uniprotkb/F1N7C9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N7C9-1", "url": "https://www.uniprot.org/uniprotkb/F1N7C9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9TTF3", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9TTF3-1", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGSGAWKRLKSMLRKDDAPLFLNDTSAFDFSDEVGDEGLSRFNKLRVVVADDGSEAPERPANGAHSALQADDDSLLDQDLPLTNSQLSLKADPCDNCSKQRELLKQRKVKTRLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLEVLSAMISVLLVYILMGFLLYEAVQRTIHMKYEINGDIMLITAAIGVAVNVIMGFLLNQSGHHHAHSHSLPSNSPTTGPRCGHNQGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYRIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKEALMKIEDVHSVEDLNIWSLTSGKPTAIVHIQLIPGSSSKWEEVQSKAKHLLLNTFGMYKCTIQLQSYRQEVNRTCANCQSSSS", "length": 429, "header": "sp|Q9TTF3-1|ZNT4_BOVIN Isoform 1 of Probable proton-coupled zinc antiporter SLC30A4 OS=Bos taurus OX=9913 GN=SLC30A4 PE=3 SV=2 CANONICAL=Q9TTF3-1" }, "isoforms": [ { "isoform_ac": "F1N7C9-1", "url": "https://www.uniprot.org/uniprotkb/F1N7C9/entry", "sequence": { "sequence": "MAGSGAWKRLKSMLRKDDAPLFLNDTSAFDFSDEVGDEGLSRFNKLRVVVADDGSEAPERPANGAHSALQADDDSLLDQDLPLTNSQLSLKADPCDNCSKQRELLKQRKVKTRLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLEVLSAMISVLLVYILMGFLLYEAVQRTIHMKYEINGDIMLITAAIGVAVNVIMGFLLNQSGHHHAHSHSLPSNSPTTGPRCGHNQGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYRIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKEALMKIEDVHSVEDLNIWSLTSGKPTAIVHIQLIPGSSSKWEEVQSKAKHLLLNTFGMYKCTIQLQSYRQEVNRTCANCQSSSS", "length": 429, "header": "tr|F1N7C9-1|ZNT4_BOVIN Computationally mapped isoform of Probable proton-coupled zinc antiporter SLC30A4 OS=Bos taurus OX=9913 GN=SLC30A4 PE=3 SV=2 CANONICAL=Q9TTF3-1" }, "locus": { "chromosome": "10", "start_pos": 64973977, "end_pos": 64948038, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061150.3", "url": "https://www.ensembl.org/id/ENSBTAT00000061150.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053701.2", "url": "https://www.ensembl.org/id/ENSBTAP00000053701.2" } ] } }, { "isoform_ac": "Q9TTF3-1", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3/entry#Q9TTF3-1", "sequence": { "sequence": "MAGSGAWKRLKSMLRKDDAPLFLNDTSAFDFSDEVGDEGLSRFNKLRVVVADDGSEAPERPANGAHSALQADDDSLLDQDLPLTNSQLSLKADPCDNCSKQRELLKQRKVKTRLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLEVLSAMISVLLVYILMGFLLYEAVQRTIHMKYEINGDIMLITAAIGVAVNVIMGFLLNQSGHHHAHSHSLPSNSPTTGPRCGHNQGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYRIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKEALMKIEDVHSVEDLNIWSLTSGKPTAIVHIQLIPGSSSKWEEVQSKAKHLLLNTFGMYKCTIQLQSYRQEVNRTCANCQSSSS", "length": 429, "header": "sp|Q9TTF3-1|ZNT4_BOVIN Isoform 1 of Probable proton-coupled zinc antiporter SLC30A4 OS=Bos taurus OX=9913 GN=SLC30A4 PE=3 SV=2 CANONICAL=Q9TTF3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Physical and linkage mapping of the bovine zinc transporter 4 (ZNT4) gene to chromosome 10.", "journal": "Anim. Genet.", "date": "1999", "authors": "Tammen I, Warren W C, Raadsma H W", "evidence": [ { "database": "UniProtKB", "id": "Q9TTF3", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3" } ], "reference": [ { "type": "PubMed", "id": "10612253", "url": "https://glygen.org/publication/PubMed/10612253" } ] }, { "title": "A whole-genome assembly of the domestic cow, Bos taurus.", "journal": "Genome Biol.", "date": "2009", "authors": "Zimin Aleksey V, Delcher Arthur L, Florea Liliana, Kelley David R, Schatz Michael C, Puiu Daniela, Hanrahan Finnian, Pertea Geo, Van Tassell Curtis P, Sonstegard Tad S, Mar\u00e7ais Guillaume, Roberts Michael, Subramanian Poorani, Yorke James A, Salzberg Steven L", "evidence": [ { "database": "UniProtKB", "id": "Q9TTF3", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3" } ], "reference": [ { "type": "PubMed", "id": "19393038", "url": "https://glygen.org/publication/PubMed/19393038" } ] } ], "pathway": [ { "id": "bta:540869", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540869", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C7N9-1", "protein_name": "Probable proton-coupled zinc antiporter SLC30A4", "gene_name": "SLC30A4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGPGLWSSIKSALRRSEPPLFLNDSSAFDFSDEAGDEDFPRFNKLRVVVADDAAEGAPEAPANGLHPAPPSDDESVAERDIALRGGPEPCGRCRSRRELCKLRRVKKRLTAAAVLYLLFMTGELVGGYVANSLAIMTDALHMLTDLSGIILTLLALWLSAKSPTKRFTFGFHRLEVLSAIISVLLVYILMAFLLYEAVQRTIHMDYEINGDIMLITAAVGVAVNLIMGFLLNQSGHLHSHSHSHRHSHVPQSNSPSAARSSGHGHSSLAVRAAFVHALGDLVQSIGVLVAAYIIRFKPEYKIADPICTYVFSILVVLTTVRILCDTGVIILEGVPRHLNVDRIKEDLMKIEDVYSIEDLNVWSLTAGKTTAIVHLQLVPGSSSKWEEVQFKARQLLLNTFGMYKCSVQLQSYKQESSKACASCQSSSA", "length": 429 }, "evidence": [ { "id": "Q9TTF3", "url": "https://omabrowser.org/oma/group/Q9TTF3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O14863-1", "protein_name": "Probable proton-coupled zinc antiporter SLC30A4", "gene_name": "SLC30A4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGSGAWKRLKSMLRKDDAPLFLNDTSAFDFSDEAGDEGLSRFNKLRVVVADDGSEAPERPVNGAHPTLQADDDSLLDQDLPLTNSQLSLKVDSCDNCSKQREILKQRKVKARLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLEVLSAMISVLLVYILMGFLLYEAVQRTIHMNYEINGDIMLITAAVGVAVNVIMGFLLNQSGHRHSHSHSLPSNSPTRGSGCERNHGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKEALMKIEDVYSVEDLNIWSLTSGKSTAIVHIQLIPGSSSKWEEVQSKANHLLLNTFGMYRCTIQLQSYRQEVDRTCANCQSSSP", "length": 429 }, "evidence": [ { "id": "Q9TTF3", "url": "https://omabrowser.org/oma/group/Q9TTF3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O35149-1", "protein_name": "Probable proton-coupled zinc antiporter SLC30A4", "gene_name": "Slc30a4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGPGAWKRLKSLLRKDDTPLFLNDTSAFDFSDEVSDEGLSRFNKLRVVVADDDSEAPERPVNGAHPALQADDDSLLDQDLPLTNSQLSLKMDPCDNCSKRRELLKQRKVKTRLTIAAVLYLLFMIGELVGGYMANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTRRFTFGFHRLEVLSAMISVMLVYVLMGFLLYEAVQRTIHMNYEINGDVMLITAAVGVAVNVIMGFLLNQSGHHHSHAHSHSLPSNSPSMVSSGHNHGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYIFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKESLMKIEDVYSVEDLNIWSLTSGKSTAIVHMQLIPGSSSKWEEVQSKAKHLLLNTFGMYKCTIQLQSYRQEVIRTCANCHSSST", "length": 430 }, "evidence": [ { "id": "Q9TTF3", "url": "https://omabrowser.org/oma/group/Q9TTF3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O55174-1", "protein_name": "Probable proton-coupled zinc antiporter SLC30A4", "gene_name": "Slc30a4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGPGAWKRLKSLLRKDDAPLFLNDTSAFDFLDEVSDEGLSRFNKLRVVVADDDSEAPERPVNGAHPALQADDDSLLDQELPLTNSQLSLKMDPCDNCSKRRELLKQRKVKTRLTIAAVLYLLFMIGELVGGYMANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTRRFTFGFHRLEVLSAMISVMLVYVLMGFLLYEAMQRTIHMNYEINGDVMLITAAVGVAVNVIMGFLLNQSGHHHSHAHSHSLPSNSPSMVSSGHSHGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYIFSLLVAFTTLRIIWDTVVIILEGVPSHLNVDYIKESLMKIEDVYSVEDLNIWSLTSGKATAIVHMQLIPGSSSKWEEVQSKAKHLLLNTFGMYKCTVQLQSYRQEATRTCANCQSSST", "length": 430 }, "evidence": [ { "id": "Q9TTF3", "url": "https://omabrowser.org/oma/group/Q9TTF3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion transmembrane transporter activity", "id": "GO:0005385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005385", "evidence": [ { "database": "UniProtKB", "id": "Q9TTF3", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q9TTF3", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3" } ], "pmid": "" }, { "name": "antiporter activity", "id": "GO:0015297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015297", "evidence": [ { "database": "UniProtKB", "id": "Q9TTF3", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "zinc ion transmembrane transport", "id": "GO:0071577", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071577", "evidence": [ { "database": "UniProtKB", "id": "Q9TTF3", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3" } ], "pmid": "" }, { "name": "response to zinc ion", "id": "GO:0010043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010043", "evidence": [ { "database": "UniProtKB", "id": "Q9TTF3", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3" } ], "pmid": "" }, { "name": "response to toxic substance", "id": "GO:0009636", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009636", "evidence": [ { "database": "UniProtKB", "id": "Q9TTF3", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3" } ], "pmid": "" }, { "name": "zinc ion import into lysosome", "id": "GO:0140916", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140916", "evidence": [ { "database": "UniProtKB", "id": "Q9TTF3", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9TTF3", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9TTF3", "url": "https://www.uniprot.org/uniprotkb/Q9TTF3" } ], "pmid": "" }, { "name": 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"MGIVVLTMKASVIEMFLVLLVTGIQSNQEMTKKMKRPKFTVPQISCDVRAGKITNVEFIVKCPPGCQDPRYHVYGADVYASYSSVCGAAVHSGVLDNSGGKILVRKVAGQSGYKGSYSNGVQSLSLPRWRESFVVSEGKPQKGVTYPSSLTYSSSKSPAAKAGETARADQSPPVPGTAAQPVTVTQAPGTTAIEATHTTLPKPSPSAGSTASGLRPQPAGQRSKDLGEPALWKPESVLLDAGFVPKEELSTQSLEPASQGDPSCKVDLSFLIDGSSSIGKRRFRIQKQFLTDVAQTLDIGPAGPLMGVVQYGDNPATQFNLKTHMNSQDVKAAIEKISQRGGLSNAGRAISFVTKNFFSKFNGNRGGAPNVAVVMVDGWPTDKVEEASRLARESGVNIFFITIEGASENEKQYMLEPNFANKAVCRTNGFYSLTVQNWFSLHKTVQPLVKRVCDTDRLACSKTCLNSADIGFVIDGSSSVGTSNFRTVLQFVANLSREFEISDMDTRIGAMQYTYEQRLEFGFDEYSTKSDVLNAIKRVGYWSGGTSTGAAIHYALEQLFKKSKPNKRKLMILITDGRSYDDIRIPAMLAHHKGVITYAIGVAWAAQDELDIIATHPARDHAFFVDEFDNLYKVVPKVIQNICTEFNSQPRN", "length": 652, "header": "sp|Q95LI2-1|VITRN_BOVIN Isoform 1 of Vitrin OS=Bos taurus OX=9913 GN=VIT PE=2 SV=2 CANONICAL=Q95LI2-1" }, "isoforms": [ { "isoform_ac": "Q95LI2-1", "url": "https://www.uniprot.org/uniprotkb/Q95LI2/entry#Q95LI2-1", "sequence": { "sequence": 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Soc. 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[ "Other" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039663", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039663", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056277", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056277", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281609", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281609", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EYDRETW", "url": "https://omabrowser.org/oma/group/EYDRETW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q95MP1", "url": "https://www.orthodb.org/?gene=Q95MP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11242", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11242", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11242:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11242:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23322", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23322", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776659", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q95MP1", "url": "https://www.uniprot.org/uniprotkb/Q95MP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q95MP1-1", "url": "https://www.uniprot.org/uniprotkb/Q95MP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDATLLLNVEGIKKTILHGGTGDLPNFITGARVTFHFRTMKCDEERTVIDDSKQVGHPMHIIIGNMFKLEVWEILLTSMRVSEVAEFWCDTIHTGVYPILSRSLRQMAEGKDPTEWHVHTCGLANMFAYHTLGYEDLDELQKEPQPLIFIIELLQVEAPSQYQRETWNLNNQEKMQAVPILHGEGNRLFKLGRYEEASNKYQEAIVCLRNLQTKEKPWEVQWLKLEKMINTLILNYCQCLLKKEEYYEVLEHTSDILRHHPGIVKAYYVRARAHAEVWNEAEAKADLEKVLELEPSMRKAVQRELRLLENRLEEKREEERLRCRNMLG", "length": 328, "header": "sp|Q95MP1-1|AIPL1_BOVIN Isoform 1 of Aryl-hydrocarbon-interacting protein-like 1 OS=Bos taurus OX=9913 GN=AIPL1 PE=1 SV=1 CANONICAL=Q95MP1-1" }, "isoforms": [ { "isoform_ac": "Q95MP1-1", "url": "https://www.uniprot.org/uniprotkb/Q95MP1/entry#Q95MP1-1", "sequence": { "sequence": "MDATLLLNVEGIKKTILHGGTGDLPNFITGARVTFHFRTMKCDEERTVIDDSKQVGHPMHIIIGNMFKLEVWEILLTSMRVSEVAEFWCDTIHTGVYPILSRSLRQMAEGKDPTEWHVHTCGLANMFAYHTLGYEDLDELQKEPQPLIFIIELLQVEAPSQYQRETWNLNNQEKMQAVPILHGEGNRLFKLGRYEEASNKYQEAIVCLRNLQTKEKPWEVQWLKLEKMINTLILNYCQCLLKKEEYYEVLEHTSDILRHHPGIVKAYYVRARAHAEVWNEAEAKADLEKVLELEPSMRKAVQRELRLLENRLEEKREEERLRCRNMLG", "length": 328, "header": "sp|Q95MP1-1|AIPL1_BOVIN Isoform 1 of Aryl-hydrocarbon-interacting protein-like 1 OS=Bos taurus OX=9913 GN=AIPL1 PE=1 SV=1 CANONICAL=Q95MP1-1" }, "locus": { "chromosome": "19", "start_pos": 25431852, "end_pos": 25422472, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010954.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010954.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010954.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010954.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Comparative analysis of aryl-hydrocarbon receptor interacting protein-like 1 (Aipl1), a gene associated with inherited retinal disease in humans.", "journal": "Mamm. Genome", "date": "2001", "authors": "Sohocki MM, Sullivan LS, Tirpak DL, Daiger SP", "evidence": [ { "database": "UniProtKB", "id": "Q95MP1", "url": "https://www.uniprot.org/uniprotkb/Q95MP1" } ], "reference": [ { "type": "PubMed", "id": "11420621", "url": "https://glygen.org/publication/PubMed/11420621" } ] }, { "title": "The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1.", "journal": "Hum. Mol. Genet.", "date": "2002", "authors": "Akey DT, Zhu X, Dyer M, Li A, Sorensen A, Blackshaw S, Fukuda-Kamitani T, Daiger SP, Craft CM, Kamitani T, Sohocki MM", "evidence": [ { "database": "UniProtKB", "id": "Q95MP1", "url": "https://www.uniprot.org/uniprotkb/Q95MP1" } ], "reference": [ { "type": "PubMed", "id": "12374762", "url": "https://glygen.org/publication/PubMed/12374762" } ] } ], "pathway": [ { "id": "bta:281609", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281609", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q924K1-1", "protein_name": "Aryl-hydrocarbon-interacting protein-like 1", "gene_name": "Aipl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDVSLLLNVEGVKKTILHGGTGELPSFITGSRVTFHFRTMKCDDERTVIDDSKQVGQPMSIIIGNMFKLEVWETLLTSMRLGEVAEFWCDTIHTGVYPMLSRSLRQVAEGKDPTSWHVHTCGLANMFAYHTLGYEDLDELQKEPQPLVFLIELLQVEAPNEYQRETWNLNNEERMQAVPLLHGEGNRLYKLGRYDQAATKYQEAIVCLRNLQTKEKPWEVEWLKLEKMINTLILNYCQCLLKKEEYYEVLEHTSDILRHHPGIVKAYYMRARAHAEVWNAEEAKADLEKVLELEPSMRKAVLRELRLLESRLADKQEEERQRCRSMLG", "length": 328 }, "evidence": [ { "id": "Q95MP1", "url": "https://omabrowser.org/oma/group/Q95MP1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9JLG9-1", "protein_name": "Aryl-hydrocarbon-interacting protein-like 1", "gene_name": "Aipl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDVSLLLNVEGVKKTILHGGTGELPNFITGSRVTFHFRTMKCDEERTVIDDSKQVGQPMNIIIGNMFKLEVWETLLTSMRLGEVAEFWCDTIHTGVYPMLSRSLRQVAEGKDPTSWHVHTCGLANMFAYHTLGYEDLDELQKEPQPLIFLIELLQVEAPNEYQRETWNLNNEERMQAVPLLHGEGNRLYKLGRYDQAATKYQEAIVCLRNLQTKEKPWEVEWLKLEKMINTLILNYCQCLLKKEEYYEVLEHTSDILRHHPGIVKAYYMRARAHAEVWNAEEAKADLEKVLELEPSMRKAVLRELRLLESRLADKQEEERQRCRSMLG", "length": 328 }, "evidence": [ { "id": "Q95MP1", "url": "https://omabrowser.org/oma/group/Q95MP1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NZN9-1", "protein_name": "Aryl-hydrocarbon-interacting protein-like 1", "gene_name": "AIPL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDAALLLNVEGVKKTILHGGTGELPNFITGSRVIFHFRTMKCDEERTVIDDSRQVGQPMHIIIGNMFKLEVWEILLTSMRVHEVAEFWCDTIHTGVYPILSRSLRQMAQGKDPTEWHVHTCGLANMFAYHTLGYEDLDELQKEPQPLVFVIELLQVDAPSDYQRETWNLSNHEKMKAVPVLHGEGNRLFKLGRYEEASSKYQEAIICLRNLQTKEKPWEVQWLKLEKMINTLILNYCQCLLKKEEYYEVLEHTSDILRHHPGIVKAYYVRARAHAEVWNEAEAKADLQKVLELEPSMQKAVRRELRLLENRMAEKQEEERLRCRNMLSQGATQPPAEPPTEPPAQSSTEPPAEPPTAPSAELSAGPPAEPATEPPPSPGHSLQH", "length": 384 }, "evidence": [ { "id": "Q95MP1", "url": "https://omabrowser.org/oma/group/Q95MP1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q95MP1", "url": "https://www.uniprot.org/uniprotkb/Q95MP1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { 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"Q99004", "uniprot_id": "AMELY_BOVIN", "mass": { "chemical_mass": 21753.0, "monoisotopic_mass": 21753.0 }, "refseq": { "ac": "NP_776665", "name": "amelogenin, Y isoform precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776665" }, "gene_names": [ { "name": "AMELY", "type": "recommended", "evidence": [ { "id": "Q99004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q99004" } ] }, { "name": "AMELY", "type": "synonym", "evidence": [ { "id": "NP_776665", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776665" } ] }, { "name": "AMGY", "type": "synonym", "evidence": [ { "id": "NP_776665", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776665" } ] } ], "protein_names": [ { "name": "Amelogenin, Y isoform", "type": "recommended", "evidence": [ { "id": "Q99004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q99004/entry#names_and_taxonomy" } ] }, { "name": "Class II amelogenin", "type": 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Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. 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heterogeneity: alternative splicing and Y-chromosomal gene transcription.", "journal": "Biochemistry", "date": "1992", "authors": "Gibson C W, Golub E E, Abrams W R, Shen G, Ding W, Rosenbloom J", "evidence": [ { "database": "UniProtKB", "id": "Q99004", "url": "https://www.uniprot.org/uniprotkb/Q99004" } ], "reference": [ { "type": "PubMed", "id": "1525172", "url": "https://glygen.org/publication/PubMed/1525172" } ] }, { "title": "Structure and expression of the bovine amelogenin gene.", "journal": "Biochemistry", "date": "1991", "authors": "Gibson C, Golub E, Herold R, Risser M, Ding W, Shimokawa H, Young M, Termine J, Rosenbloom J", "evidence": [ { "database": "UniProtKB", "id": "Q99004", "url": "https://www.uniprot.org/uniprotkb/Q99004" } ], "reference": [ { "type": "PubMed", "id": "1989679", "url": "https://glygen.org/publication/PubMed/1989679" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { 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"MQLSLALCLVCLLVHAAFRVVEGQGWQAFKNDATEIIPELGEYPEPLPELNNKTMNRAENGGRPPHHPFETKDASEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGAAPRARKVRLVASCKCKRLTRFHNQSELKDFGPEAARPQTGRKLRPRARGTKASRAELENAY", "length": 212, "header": "sp|Q9BG79-1|SOST_BOVIN Isoform 1 of Sclerostin OS=Bos taurus OX=9913 GN=SOST PE=2 SV=2 CANONICAL=Q9BG79-1" }, "isoforms": [ { "isoform_ac": "Q9BG79-1", "url": "https://www.uniprot.org/uniprotkb/Q9BG79/entry#Q9BG79-1", "sequence": { "sequence": "MQLSLALCLVCLLVHAAFRVVEGQGWQAFKNDATEIIPELGEYPEPLPELNNKTMNRAENGGRPPHHPFETKDASEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGAAPRARKVRLVASCKCKRLTRFHNQSELKDFGPEAARPQTGRKLRPRARGTKASRAELENAY", "length": 212, "header": "sp|Q9BG79-1|SOST_BOVIN Isoform 1 of Sclerostin OS=Bos taurus OX=9913 GN=SOST PE=2 SV=2 CANONICAL=Q9BG79-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 174, "start_aa": "Asn", "end_pos": 174, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn174", "evidence": [ { "id": "Q9BG79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BG79#ptm_processing" } ], "filter_code": "001000000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 52, "start_aa": "Asn", "end_pos": 52, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn52", "evidence": [ { "id": "Q9BG79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9BG79#ptm_processing" } ], "filter_code": "001000000000000000000.00010000000000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein.", "journal": "Am. J. Hum. Genet.", "date": "2001", "authors": "Brunkow M E, Gardner J C, Van Ness J, Paeper B W, Kovacevich B R, Proll S, Skonier J E, Zhao L, Sabo P J, Fu Y, Alisch R S, Gillett L, Colbert T, Tacconi P, Galas D, Hamersma H, Beighton P, Mulligan J", "evidence": [ { "database": "UniProtKB", "id": "Q9BG79", "url": "https://www.uniprot.org/uniprotkb/Q9BG79" } ], "reference": [ { "type": "PubMed", "id": "11179006", "url": "https://glygen.org/publication/PubMed/11179006" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q9BG79", "url": "https://www.uniprot.org/uniprotkb/Q9BG79" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", 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"annotation": "Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_776583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776583" }, { "database": "PubMed", "id": "27224046", "url": "https://glygen.org/publication/PubMed/27224046" } ] }, { "annotation": "Required for normal acrosome reaction and for normal male fertility (By similarity). 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"glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The PrP-like protein Doppel gene in sheep and cattle: cDNA sequence and expression.", "journal": "Mamm. Genome", "date": "2001", "authors": "Tranulis M A, Espenes A, Comincini S, Skretting G, Harbitz I", "evidence": [ { "database": "UniProtKB", "id": "Q9GK16", "url": "https://www.uniprot.org/uniprotkb/Q9GK16" } ], "reference": [ { "type": "PubMed", "id": "11331946", "url": "https://glygen.org/publication/PubMed/11331946" } ] }, { "title": "Genomic organization, comparative analysis, and genetic polymorphisms of the bovine and ovine prion Doppel genes (PRND).", "journal": "Mamm. Genome", "date": "2001", "authors": "Comincini S, Foti M G, Tranulis M A, Hills D, Di Guardo G, Vaccari G, Williams J L, Harbitz I, Ferretti L", "evidence": [ { "database": "UniProtKB", "id": "Q9GK16", "url": "https://www.uniprot.org/uniprotkb/Q9GK16" } ], "reference": [ { "type": "PubMed", "id": "11641722", "url": "https://glygen.org/publication/PubMed/11641722" } ] }, { "title": "Functional mapping of the bovine Doppel gene promoter region.", "journal": "Gene", "date": "2005-08-15", "authors": "Del Vecchio Igor, Azzalin Alberto, Guidi Elena, Amati Giuseppe, Caramori Tiziana, Uboldi Cristina, Comincini Sergio, Ferretti Luca", "evidence": [ { "database": "RefSeq", "id": "NP_776583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776583" } ], "reference": [ { "type": "PubMed", "id": "15964157", "url": "https://glygen.org/publication/PubMed/15964157" } ] }, { "title": "Comparative genomic organization of the human and bovine PRNP locus.", "journal": "Genomics", "date": "2006-05", "authors": "Choi Sang-Haeng, Kim Il-Chul, Kim Dae-Soo, Kim Dae-Won, Chae Sung-Hwa, Choi Han-Ho, Choi Inho, Yeo Jung-Sou, Song Mi-Na, Park Hong-Seog", "evidence": [ { "database": "UniProtKB", "id": "Q9GK16", "url": "https://www.uniprot.org/uniprotkb/Q9GK16" }, { "database": "RefSeq", "id": "NP_776583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776583" } ], "reference": [ { "type": "PubMed", "id": "16460908", "url": "https://glygen.org/publication/PubMed/16460908" } ] }, { "title": "Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle.", "journal": "PloS one", "date": "2016", "authors": "Brunelle Brian W, O'Grady Allison M, Nicholson Eric M, Seabury Christopher M", "evidence": [ { "database": "RefSeq", "id": "NP_776583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776583" } ], "reference": [ { "type": "PubMed", "id": "27224046", "url": "https://glygen.org/publication/PubMed/27224046" } ] } ], "pathway": [ { "id": 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"id": "Q9GK68", "url": "https://www.uniprot.org/uniprotkb/Q9GK68" } ], "reference": [ { "type": "PubMed", "id": "11918837", "url": "https://glygen.org/publication/PubMed/11918837" } ] }, { "title": "Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "2003-02", "authors": "Kaivo-Oja Noora, Bondestam Jonas, K\u00e4m\u00e4r\u00e4inen Meerit, Koskimies Janne, Vitt Ursula, Cranfield Mark, Vuojolainen Kaisa, Kallio Janne P, Olkkonen Vesa M, Hayashi Masaru, Moustakas Aristidis, Groome Nigel P, ten Dijke Peter, Hsueh Aaron J W, Ritvos Olli", "evidence": [ { "database": "RefSeq", "id": "NP_777106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777106" } ], "reference": [ { "type": "PubMed", "id": "12574210", "url": "https://glygen.org/publication/PubMed/12574210" } ] }, { "title": "Spatio-temporal expression of the germ cell marker genes MATER, ZAR1, GDF9, BMP15,andVASA in adult bovine tissues, oocytes, and preimplantation embryos.", "journal": "Biology of reproduction", "date": "2004-10", "authors": "Pennetier Sophie, Uzbekova Svetlana, Perreau Christine, Papillier Pascal, Mermillod Pascal, Dalbi\u00e8s-Tran Rozenn", "evidence": [ { "database": "RefSeq", "id": "NP_777106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777106" } ], "reference": [ { "type": "PubMed", "id": "15189828", "url": "https://glygen.org/publication/PubMed/15189828" } ] }, { "title": "Growth differentiation factor 9 (GDF9) stimulates proliferation and inhibits steroidogenesis by bovine theca cells: influence of follicle size on responses to GDF9.", "journal": "Biology of reproduction", "date": "2008-02", "authors": "Spicer Leon J, Aad Pauline Y, Allen Dustin T, Mazerbourg Sabine, Payne Anita H, Hsueh Aaron J", "evidence": [ { "database": "RefSeq", "id": "NP_777106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777106" } ], "reference": [ { "type": "PubMed", "id": "17959852", "url": "https://glygen.org/publication/PubMed/17959852" } ] }, { "title": "The ratio of growth differentiation factor 9: bone morphogenetic protein 15 mRNA expression is tightly co-regulated and differs between species over a wide range of ovulation rates.", "journal": "Mol. Cell. Endocrinol.", "date": "2012", "authors": "Crawford Janet L, McNatty Kenneth P", "evidence": [ { "database": "UniProtKB", "id": "Q9GK68", "url": "https://www.uniprot.org/uniprotkb/Q9GK68" } ], "reference": [ { "type": "PubMed", "id": "21970812", "url": "https://glygen.org/publication/PubMed/21970812" } ] }, { "title": "Single nucleotide polymorphisms in the bovine genome are associated with the number of oocytes collected during ovum pick up.", "journal": "Animal reproduction science", "date": "2012-10", "authors": "Santos-Biase W K F, Biase F H, Buratini J, Balieiro J, Watanabe Y F, Accorsi M F, Ferreira C R, Stranieri P, Caetano A R, Meirelles F V", "evidence": [ { "database": "RefSeq", "id": "NP_777106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777106" } ], "reference": [ { "type": "PubMed", "id": "22959639", "url": "https://glygen.org/publication/PubMed/22959639" } ] }, { "title": "Alterations in bone morphogenetic protein 15, growth differentiation factor 9, and gene expression in granulosa cells in preovulatory follicles of dairy cows given porcine LH.", "journal": "Theriogenology", "date": "2016-04-15", "authors": "Behrouzi Amir, Colazo Marcos Germ\u00e1n, Ambrose Divakar Justus", "evidence": [ { "database": "RefSeq", "id": "NP_777106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777106" } ], "reference": [ { "type": "PubMed", "id": "26794084", "url": "https://glygen.org/publication/PubMed/26794084" } ] }, { "title": "GDF9 and BMP15 induce development of antrum-like structures by bovine granulosa cells without oocytes.", "journal": "The Journal of reproduction and development", "date": "2018-10-12", "authors": "Alam Md Hasanur, Lee Jibak, Miyano Takashi", "evidence": [ { "database": "RefSeq", "id": "NP_777106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777106" } ], "reference": [ { "type": "PubMed", "id": "30033985", "url": "https://glygen.org/publication/PubMed/30033985" } ] }, { "title": "Association between Bovine GDF9 SNPs and Calving Rate (Superovulation) in Holstein-Friesian Cows.", "journal": "Archives of Razi Institute", "date": "2021-10", "authors": "Rasheed S T, Younis L S, Aboud Q M", "evidence": [ { "database": "RefSeq", "id": "NP_777106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777106" } ], "reference": [ { "type": "PubMed", "id": "35096339", "url": "https://glygen.org/publication/PubMed/35096339" } ] } ], "pathway": [ { "id": "bta:282574", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282574", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YTB1-1", "protein_name": "Growth/differentiation factor 9", "gene_name": "GDF9", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": 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"http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF58", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001035587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035587", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9GL32", "url": "https://www.uniprot.org/uniprotkb/Q9GL32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9GL32-1", "url": "https://www.uniprot.org/uniprotkb/Q9GL32-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9GL32-2", "url": "https://www.uniprot.org/uniprotkb/Q9GL32-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLHLSEFSGPDALLVKSTEGCCSEPSTDLTRLPARDPPAATGYPAGDFLSWALSSCGAGEYLTDSCLLEGPAPTPPPGLGYSGSFFIQAVPEHPHDPEALFNLMSGILGLTPFPGAEAAASRSPLDASFPAGSDALLPGPPDLFSPDPGAAAFPEAFWEASPSAGAPSQCLYEPHLSAPDVKPGLRAPPASPALDTASAFKGPYSPWELLSAGAPGSCGSQGGYQAAPEARFPTTGAKIEDLLSISCPAELPGGPASRLYTMGTYDAFPLAPGDLGEGAESLPGLLTPPSGEGGSSGEGGEFLDGTQPELSPLGLRSATADLPKPLVADIPGSSAVPEPPVPPPAPFPPAKARRKGRRGGKCSARCFCPRPHAKAFACPVESCVRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLKQKARAEERLKGLGFYSLGLSFAAL", "length": 482, "header": "sp|Q9GL32-1|EGR4_BOVIN Isoform 1 of Early growth response protein 4 OS=Bos taurus OX=9913 GN=EGR4 PE=2 SV=1 CANONICAL=Q9GL32-1" }, "isoforms": [ { "isoform_ac": "Q9GL32-1", "url": "https://www.uniprot.org/uniprotkb/Q9GL32/entry#Q9GL32-1", "sequence": { "sequence": "MLHLSEFSGPDALLVKSTEGCCSEPSTDLTRLPARDPPAATGYPAGDFLSWALSSCGAGEYLTDSCLLEGPAPTPPPGLGYSGSFFIQAVPEHPHDPEALFNLMSGILGLTPFPGAEAAASRSPLDASFPAGSDALLPGPPDLFSPDPGAAAFPEAFWEASPSAGAPSQCLYEPHLSAPDVKPGLRAPPASPALDTASAFKGPYSPWELLSAGAPGSCGSQGGYQAAPEARFPTTGAKIEDLLSISCPAELPGGPASRLYTMGTYDAFPLAPGDLGEGAESLPGLLTPPSGEGGSSGEGGEFLDGTQPELSPLGLRSATADLPKPLVADIPGSSAVPEPPVPPPAPFPPAKARRKGRRGGKCSARCFCPRPHAKAFACPVESCVRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLKQKARAEERLKGLGFYSLGLSFAAL", "length": 482, "header": "sp|Q9GL32-1|EGR4_BOVIN Isoform 1 of Early growth response protein 4 OS=Bos taurus OX=9913 GN=EGR4 PE=2 SV=1 CANONICAL=Q9GL32-1" }, "locus": {} }, { "isoform_ac": "Q9GL32-2", "url": "https://www.uniprot.org/uniprotkb/Q9GL32/entry#Q9GL32-2", "sequence": { "sequence": "MLHLSEFSGPDALLVKSTEGCCSEPSTDLTRLPARDPPAATGYPAAGDFLSWALSSCGAGEYLTDSCLLEGPAPTPPPGLGYSGSFFIQAVPEHPHDPEALFNLMSGILGLTPFPGAEAAASRSPLDASFPAGSDALLPGPPDLFSPDPGAAAFPEAFWEASPSAGAPSQCLYEPHLSAPDVKPGLRAPPASPALDTASAFKGPYSPWELLSAGAPGSCGSQGGYQAAPEARFPTTGAKIEDLLSISCPAELPGGPASRLYTMGTYDAFPLAPGDLGEGAESLPGLLTPPSGEGGSSGEGGEFLDGTQPELSPLGLRSATADLPKPLVADIPGSSAVPEPPVPPPAPFPPAKARRKGRRGGKCSARCFCPRPHAKAFACPVESCVRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLKQKARAEERLKGLGFYSLGLSFAAL", "length": 483, "header": "sp|Q9GL32-2|EGR4_BOVIN Isoform 2 of Early growth response protein 4 OS=Bos taurus OX=9913 GN=EGR4 PE=2 SV=1 CANONICAL=Q9GL32-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 74, "start_aa": "Thr", "end_pos": 74, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr74", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Cloning and genomic structure of the bovine EGR4 gene and evaluation as candidate gene for bovine spinal dysmyelination.", "journal": "Anim. Genet.", "date": "2003", "authors": "Nissen P H, Thomsen B, Offenberg H, Thomsen P D, Bendixen C", "evidence": [ { "database": "UniProtKB", "id": "Q9GL32", "url": "https://www.uniprot.org/uniprotkb/Q9GL32" } ], "reference": [ { "type": "PubMed", "id": "12648095", "url": "https://glygen.org/publication/PubMed/12648095" } ] } ], "pathway": [ { "id": "bta:407155", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407155", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9GL32", "url": "https://www.uniprot.org/uniprotkb/Q9GL32" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "Q9GL32", "url": "https://www.uniprot.org/uniprotkb/Q9GL32" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q9GL32", "url": "https://www.uniprot.org/uniprotkb/Q9GL32" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q9GL32", "url": "https://www.uniprot.org/uniprotkb/Q9GL32" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q9GL32", "url": "https://www.uniprot.org/uniprotkb/Q9GL32" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q9GL32", "url": "https://www.uniprot.org/uniprotkb/Q9GL32" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9GL32-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 482, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9GL32-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9GL32" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 74 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 414, "end_pos": 416 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q9GLX0-1", "uniprot_ac": "Q9GLX0", "uniprot_id": "ACKR1_BOVIN", "mass": { "chemical_mass": 35414.0, "monoisotopic_mass": 35414.0 }, "refseq": { "ac": "NP_001015634", "name": "atypical chemokine receptor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015634" }, "gene_names": [ { "name": "ACKR1", "type": "recommended", "evidence": [ { "id": "Q9GLX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GLX0" } ] }, { "name": "ACKR1", "type": "synonym", "evidence": [ { "id": "NP_001015634", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015634" } ] }, { "name": "DARC", "type": "synonym", "evidence": [ { "id": "NP_001015634", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015634" }, { "id": "Q9GLX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GLX0" } ] }, { "name": "FY", "type": "synonym", "evidence": [ { "id": "Q9GLX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GLX0" } ] } ], "protein_names": [ { "name": "Atypical chemokine receptor 1", "type": "recommended", "evidence": [ { "id": "Q9GLX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GLX0/entry#names_and_taxonomy" } ] }, { "name": "Duffy antigen/chemokine receptor", "type": "synonym", "evidence": [ { "id": "Q9GLX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GLX0/entry#names_and_taxonomy" } ] }, { "name": "Duffy blood group, chemokine receptor", "type": "synonym", "evidence": [ { "id": "NP_001015634", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015634" } ] }, { "name": "atypical chemokine receptor 1 (Duffy blood group)", "type": "synonym", "evidence": [ { "id": "NP_001015634", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015634" } ] }, { "name": "atypical chemokine receptor 1", "type": "synonym", "evidence": [ { "id": "NP_001015634", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015634" } ] }, { "name": "blood group antigen", "type": "synonym", "evidence": [ { "id": "NP_001015634", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015634" } ] }, { "name": "duffy antigen/chemokine receptor", "type": "synonym", "evidence": [ { "id": "NP_001015634", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015634" } ] }, { "name": "duffy antigen/receptor for chemokine glycoprotein", "type": "synonym", "evidence": [ { "id": "NP_001015634", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015634" } ] } ], "function": [ { "annotation": "Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9GLX0", "url": "https://www.uniprot.org/uniprotkb/Q9GLX0#function" } ] }, { "annotation": "PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF109158.1.", "evidence": [ { "database": "RefSeq", "id": "NP_001015634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015634" } ] }, { "annotation": "The 5' flanking region of the DARC gene was isolated and characterized", "evidence": [ { "database": "RefSeq", "id": "NP_001015634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015634" }, { "database": "PubMed", "id": "19559488", "url": "https://glygen.org/publication/PubMed/19559488" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9GLX0", "url": "https://www.uniprot.org/uniprotkb/Q9GLX0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACKR1", "url": "https://www.uniprot.org/uniprotkb/Q9GLX0", "locus": { "chromosome": "3", "start_pos": 10526128, "end_pos": 10528389, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003220", "url": "https://www.ensembl.org/id/ENSBTAG00000003220" } ] } } ], "crossref": [ { "id": "Q9GLX0", "url": "https://alphafold.ebi.ac.uk/entry/Q9GLX0", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15010", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15010", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "528076", "url": "https://www.ncbi.nlm.nih.gov/gene/528076", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005384", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005384", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528076", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528076", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q9GLX0", "url": "https://www.orthodb.org/?gene=Q9GLX0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14181", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14181", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14181:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14181:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "NP_001015634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015634", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9GLX0", "url": "https://www.uniprot.org/uniprotkb/Q9GLX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9GLX0-1", "url": "https://www.uniprot.org/uniprotkb/Q9GLX0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNCLYPVADDNSTKLAIKEDFLIDFPEDYYPDYNETDVEAAAPCHSCSLLNYSSLPFFILVSILGILASGTILYALLRPLFRWQLYQDRSTLVQLAVGSALFSIVVPILARGLSGALITSLCHLAHLVAYGSAFAQALLIGYHACLGPQLGAGQVPGLRLGVTVGLWGVAALLSLPVVLGSDTSQGLCTVTFSGEWETLRYIHAAACFAIFVLLPLGLLGTKGLKTVLGRAPCPWVDVLWVWFIFWWPQGMTLGLDSLVRSKAIVVSTCPAQQALDMLLDVAEALAILHCVATPLLLAWVCYQATHTSPPSLPLPTTQTSHLDTLGGKS", "length": 330, "header": "sp|Q9GLX0-1|ACKR1_BOVIN Isoform 1 of Atypical chemokine receptor 1 OS=Bos taurus OX=9913 GN=ACKR1 PE=2 SV=2 CANONICAL=Q9GLX0-1" }, "isoforms": [ { "isoform_ac": "Q9GLX0-1", "url": "https://www.uniprot.org/uniprotkb/Q9GLX0/entry#Q9GLX0-1", "sequence": { "sequence": "MGNCLYPVADDNSTKLAIKEDFLIDFPEDYYPDYNETDVEAAAPCHSCSLLNYSSLPFFILVSILGILASGTILYALLRPLFRWQLYQDRSTLVQLAVGSALFSIVVPILARGLSGALITSLCHLAHLVAYGSAFAQALLIGYHACLGPQLGAGQVPGLRLGVTVGLWGVAALLSLPVVLGSDTSQGLCTVTFSGEWETLRYIHAAACFAIFVLLPLGLLGTKGLKTVLGRAPCPWVDVLWVWFIFWWPQGMTLGLDSLVRSKAIVVSTCPAQQALDMLLDVAEALAILHCVATPLLLAWVCYQATHTSPPSLPLPTTQTSHLDTLGGKS", "length": 330, "header": "sp|Q9GLX0-1|ACKR1_BOVIN Isoform 1 of Atypical chemokine receptor 1 OS=Bos taurus OX=9913 GN=ACKR1 PE=2 SV=2 CANONICAL=Q9GLX0-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 12, "start_aa": "Asn", "end_pos": 12, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn12", "evidence": [ { "id": "Q9GLX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GLX0#ptm_processing" } ], "filter_code": "001000000000000000000.00010000000000.0.01000" }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", 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Cell Biol.", "date": "2000", "authors": "Hinuma S, Shintani Y, Fukusumi S, Iijima N, Matsumoto Y, Hosoya M, Fujii R, Watanabe T, Kikuchi K, Terao Y, Yano T, Yamamoto T, Kawamata Y, Habata Y, Asada M, Kitada C, Kurokawa T, Onda H, Nishimura O, Tanaka M, Ibata Y, Fujino M", "evidence": [ { "database": "UniProtKB", "id": "Q9GM96", "url": "https://www.uniprot.org/uniprotkb/Q9GM96" } ], "reference": [ { "type": "PubMed", "id": "11025660", "url": "https://glygen.org/publication/PubMed/11025660" } ] }, { "title": "Characteristics and distribution of endogenous RFamide-related peptide-1.", "journal": "Biochim. Biophys. Acta", "date": "2001", "authors": "Fukusumi S, Habata Y, Yoshida H, Iijima N, Kawamata Y, Hosoya M, Fujii R, Hinuma S, Kitada C, Shintani Y, Suenaga M, Onda H, Nishimura O, Tanaka M, Ibata Y, Fujino M", "evidence": [ { "database": "UniProtKB", "id": "Q9GM96", "url": "https://www.uniprot.org/uniprotkb/Q9GM96" } ], "reference": [ { "type": "PubMed", "id": "11583817", "url": "https://glygen.org/publication/PubMed/11583817" } ] }, { "title": "Bovine C-terminal octapeptide of RFamide-related peptide-3 suppresses luteinizing hormone (LH) secretion from the pituitary as well as pulsatile LH secretion in bovines.", "journal": "Domestic animal endocrinology", "date": "2009-05", "authors": "Kadokawa H, Shibata M, Tanaka Y, Kojima T, Matsumoto K, Oshima K, Yamamoto N", "evidence": [ { "database": "RefSeq", "id": "NP_776593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776593" } ], "reference": [ { "type": "PubMed", "id": "19328642", "url": "https://glygen.org/publication/PubMed/19328642" } ] } ], "pathway": [ { "id": "bta:281451", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281451", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2M0V3-1", "protein_name": "Pro-FMRFamide-related neuropeptide VF", "gene_name": "Npvf", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEIISSKRFILLTLATSSLLTSNIFCTDELMVPHCHSKEKDGKYSQPRGIPKGEKERSVTFQELKDWGAKNVIKMSPAPANKVPHSAANLPLRFGRTLEEERSPRARANMEAMTLSRVPSLPQRFGRTTARSIPKTLSHLLQRSLHSLATSELLYAMTCQHQEIQSPDGKQARRQAFMETDDEEGKHEK", "length": 189 }, "evidence": [ { "id": "Q9GM96", "url": "https://omabrowser.org/oma/group/Q9GM96/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9ESQ8-1", "protein_name": "Pro-FMRFamide-related neuropeptide VF", "gene_name": "Npvf", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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May serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9GMS5", "url": "https://www.uniprot.org/uniprotkb/Q9GMS5#function" }, { "database": "UniProtKB", "id": "Q17R60", "url": "https://www.uniprot.org/uniprotkb/Q17R60#function" }, { "database": "UniProtKB", "id": "Q8JIR8", "url": "https://www.uniprot.org/uniprotkb/Q8JIR8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9GMS5", "url": "https://www.uniprot.org/uniprotkb/Q9GMS5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IMPG1", "url": "https://www.uniprot.org/uniprotkb/Q9GMS5", "locus": { "chromosome": "9", "start_pos": 15560552, "end_pos": 15722413, "strand": "+", "evidence": [ { 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"N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 656, "start_aa": "Asn", "end_pos": 656, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn656", "evidence": [ { "id": "Q9GMS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9GMS5#ptm_processing" } ], "filter_code": "001000000000000000000.00010000000000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Isolation and characterization of mucinlike glycoprotein associated with photoreceptor cells.", "journal": "Invest. 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Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (By similarity). In response to THBS1, negatively modulates wound healing. Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). May play a role in membrane transport and/or integrin dependent signal transduction (By similarity). May prevent premature elimination of red blood cells (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9N0K1", "url": "https://www.uniprot.org/uniprotkb/Q9N0K1#function" }, { "database": "UniProtKB", "id": "Q08722", "url": "https://www.uniprot.org/uniprotkb/Q08722#function" }, { "database": "UniProtKB", "id": "P97829", "url": "https://www.uniprot.org/uniprotkb/P97829#function" }, { "database": "UniProtKB", "id": "Q61735", "url": "https://www.uniprot.org/uniprotkb/Q61735#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9N0K1", "url": "https://www.uniprot.org/uniprotkb/Q9N0K1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD47", "url": "https://www.uniprot.org/uniprotkb/Q9N0K1", "locus": { "chromosome": "1", "start_pos": 52712128, 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"InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037805", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037805", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "Q9N0K1", "url": "https://www.orthodb.org/?gene=Q9N0K1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10613", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10613", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10613:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10613:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04549", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04549", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08204", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08204", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "Q9N0K1", "url": "https://www.uniprot.org/uniprotkb/Q9N0K1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9N0K1-1", "url": "https://www.uniprot.org/uniprotkb/Q9N0K1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWPLVVVLLLGSVRCGSAQLIFNAIKSVEYTLCNQTVVIPCFVNNVETKNITELYVRWKFKGENIFIFDGSQRMSKPSSNFSSAEIAPSELLRGIASLKMAKSDAVLGNYTCEVTELSREGETIIELKYRVVSWFSPNENILIVIFPVLAILLFWGQFGIVTLKYKSNYTKEKAIFLLVAGLLLTVLVIVGAFLFIPGGYSTKNASGLGLIVLPTIILILLHYCVFMIAMGMSSFTISILILQLLGYVLSVVGFSLCVSECIPVHGPLLISGLGIIALAELLGLVYMKCVASNHRTIQPPRNN", "length": 303, "header": "sp|Q9N0K1-1|CD47_BOVIN Isoform 1 of Leukocyte surface antigen CD47 OS=Bos taurus OX=9913 GN=CD47 PE=2 SV=1 CANONICAL=Q9N0K1-1" }, "isoforms": [ { "isoform_ac": "Q9N0K1-1", "url": "https://www.uniprot.org/uniprotkb/Q9N0K1/entry#Q9N0K1-1", "sequence": { "sequence": "MWPLVVVLLLGSVRCGSAQLIFNAIKSVEYTLCNQTVVIPCFVNNVETKNITELYVRWKFKGENIFIFDGSQRMSKPSSNFSSAEIAPSELLRGIASLKMAKSDAVLGNYTCEVTELSREGETIIELKYRVVSWFSPNENILIVIFPVLAILLFWGQFGIVTLKYKSNYTKEKAIFLLVAGLLLTVLVIVGAFLFIPGGYSTKNASGLGLIVLPTIILILLHYCVFMIAMGMSSFTISILILQLLGYVLSVVGFSLCVSECIPVHGPLLISGLGIIALAELLGLVYMKCVASNHRTIQPPRNN", "length": 303, "header": "sp|Q9N0K1-1|CD47_BOVIN Isoform 1 of Leukocyte surface antigen CD47 OS=Bos taurus OX=9913 GN=CD47 PE=2 SV=1 CANONICAL=Q9N0K1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 109, "start_aa": "Asn", "end_pos": 109, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn109", "evidence": [ { "id": "Q9N0K1", "database": "UniProtKB", "url": 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"n_linked_sites": [ 34 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 34, "end_pos": 36 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": 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}, { "field": "n_linked_sites", "count": 1 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_n_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q9TTK4-1", "uniprot_ac": "Q9TTK4", "uniprot_id": "LYST_BOVIN", "mass": { "chemical_mass": 428601.0, "monoisotopic_mass": 428601.0 }, "refseq": { "ac": "NP_776445", "name": "lysosomal-trafficking regulator", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776445" }, "gene_names": [ { "name": "LYST", "type": "recommended", "evidence": [ { "id": "Q9TTK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4" } ] }, { "name": "CHS1", "type": "synonym", "evidence": [ { "id": "NP_776445", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776445" } ] }, { "name": "LYST", "type": "synonym", "evidence": [ { "id": "NP_776445", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776445" } ] } ], "protein_names": [ { "name": "Lysosomal-trafficking regulator", "type": "recommended", "evidence": [ { "id": "Q9TTK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4/entry#names_and_taxonomy" } ] }, { "name": "lysosomal-trafficking regulator", "type": "synonym", "evidence": [ { "id": "NP_776445", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776445" } ] } ], "function": [ { "annotation": "May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK4", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9TTK4", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LYST", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4", "locus": { "chromosome": "28", "start_pos": 8379173, "end_pos": 8548559, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016804", "url": "https://www.ensembl.org/id/ENSBTAG00000016804" } ] } } ], "crossref": [ { "id": "cd01201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06071", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06071", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "281072", "url": "https://www.ncbi.nlm.nih.gov/gene/281072", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023362", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023362", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281072", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281072", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q9TTK4", "url": "https://www.orthodb.org/?gene=Q9TTK4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13743", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13743", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13743:SF86", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13743:SF86", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02138", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02138", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14844", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14844", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776445", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9TTK4", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9TTK4-1", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQEEKATDFNLPFSAGIILTKEKNSSSQRSTQEKLYLEGSAPAGQVSAKVNVFRKSRRQRKTTHRYSVRDARKTQLSTSDSEVNSDDKSIVMTKYRRSHVLQHFVKQCPKEDHLTAKLNHLSTKEQTPPDTMALENSREIIPREESNTDILSEPAALSTISHMNNSPFDLCHVLLSLLEKVCKFDITLNHNSALAASVVPTLTEFLAGFGDCCNLSDNLEGQMVSAGWTEEPVALIQRMLFRTVLHLMSVDISMAEVMPENLRKNLTELLRAALKIRTFLEKQPDPFAPRQKKTLQEVQDDFVFSKYCHRVLLLPELLEGVLQILICCLQSAASNPFFFSQAMDLVQEFIQHHGFHLFETAVLQMEWLVVRDGVPPEASGHLKALINNVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGDVYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVQNIGICCCMDPKSVIVPLLHAFKLPALKSCQQHILNILNKLILDQLGGAEIPQKTKKAACNICTVDSDQLAKLEETLQGSSYNAEPSSGLSSPSYRFQGILPSSGSEDLLWKWDALEAYQNFVFEEDRLQSVQIANHICSLIQKGNVVVQWKLYNCIFNPVLQRGVELAHHCQQLSISSAQTHVCSHHNQCLPQEVLQIYLKTLPTLLKSRVIRDLFLSCNGVNQIIELNYLDGIRNHSLKAFETLIISLGEQQKDSSIPGIDGIDLEQKELSSLNVGTLYNQQAYSDSQSLSKFYARLKDAYPKKRKSVVQDIHISTINLFLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLQHMLPCFSLESLVLPSPRHMHQAADVWSMCRWIYMLSPIFRKQFYRLGGFQVCHKLIFMVIQDLFRNPEEEQGRKEGDRTMNENQDLNRISQPEITVKEDLLSLTVKIDPTPTELSSLKKSADSLGRLESEHLSSINVEQIPAVEAVPEETKVFMSRESETLLQGIRLLEALLAICLHGTRASQQKLELELPNQNLSVETILLEMRDHLSKSKVTETELAKPLFDALLRVALGNHSADFEHDDAMTEKSHQSEEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDSETWDDGVDLKPEAESFIASSSPNDLLENLSQGEIIYPEICTLELNLLSTGKAKLDVLAHVFESFLKIIRQKEKNIFLLMQQGTVKNLLGGFLSILTQTDSDFQACQRVLVDLLVSLMSSRTCSEELTLLLRIFLEKSPCTEILLLGILKIVESDITMSPSQYLTFPLLHTPNLSNGVSSQKCPGILNSKAMGLLRRARVSQSKKEGDSESFPQQLLSSWHIAPVHLPLLGQPHLSEGFSISLWFNVECIHEPESTTEKGKKTRKRNKSLVLLDSSFDGTENNRLEGAAYVNPGERLIEEGCVHMISLGSKALIIQVWADPHTGTFIFRVCMDSNDDTKVVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKKNIHGKISIWISGQRKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEESLQLAGKWDLGNLLLFNGAKIGSQEAFYLYACGPNHTSIMPCKYGKPVNDYSKYINTEILQCEQIRELFMTSKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVHNILLEPHHLKNLQPTECKTLQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRIHELENCNGLSMIHQVLIKQKCIVGFHILKTLLEGCCGEDIIHINENGELKLDVESNAIIQDVKLLEELLLDWKIWNKAEHGVWETLLAALEVLIRADHQQQMFNIKQLLKARVVHHFLLTCQVLQEHKEGQLISMPQEVCRSFVKITAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVQSIMYLRHSSSGGKSVTSPGFMIISPSDFTASPPEGNNSSSAVPKQVTASMLRSRSLPAFPTASPHIKPRKLTGSLGCSIDKLQSFVDDGVASQPEKWSPLRSSETLEKSKQDAFISSCESAKMVCETEPALLAQASVSDIPKGALELPAVNIDHKDFGAEPRSDDDSPGDESCPRRPLYLKGLASFQRSHSTIASLGLAFPSQNGSAAVGRWPSLVDRNADDWENFALSLGYEPHHSRTAGAHSVTEDCLVPICCGLYELLSGVLLILPDVMLEDVMDRLIQADTLLVLVNHPSPAVQQEVIKLLDAYFNRASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMFFGRRIGLDEEFDLEDVKNMGLFQKWSVIPILGLIETSLYDNVLLHNALLLLLQILNSCSKVADMLLDNGLLYVLCNTVATLNGLEKIIPLNEYRLLACDIQQLFIAVTIHACSSSGSQYFRVIEDLIVLLGYLQNSKNKRTQNMAVALQFRVLQAAMEFIRTTANHDSENLTDSLQSPSVPHHTMFQKRKSIAGPRKFLLAQTDSLLMKMRSVASDELHVMMQRRMSQENPVQATETELAQRLQRLTVFAVNRIVYQEFNPDIIDILSTPESTTQSRTSASQTEISEENIHHEQPSVFNPFQKEMFMYLVEGFKVSSASGKTSSSKQQWAKILWSCKETFRMQLGRLLVHMLSPAHPSQERKQIFEIVREPNHQEILRECLSPSLQHGAKLVLYLSELIHNHKDELTEEELDTAELLMNALKLCGHKCIPPSASTKSDLIRVIKEEQRKYETEEGVNKANWQKTVNNNQQSLFQRLDSKSKDISKIAADITQAVSLSQGIERKKVIQHIRGMYKVDLSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCYLTIPNKYLLRDRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVECSNLQGELEPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRNDVYHSILTNNLPNLLEYGNITALTHLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLSDPSVYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFQSAHASRPGSKLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQSEPPINFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYSNRFTSGTPSEIEMESQIHLYGHTEEISSLFVCKPYSIMISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETTGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGISINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIVSLTFSCDGHHLYTANSDGTVIAWCRKDQQRLKHPMFYSFLSSYAAG", "length": 3796, "header": "sp|Q9TTK4-1|LYST_BOVIN Isoform 1 of Lysosomal-trafficking regulator OS=Bos taurus OX=9913 GN=LYST PE=1 SV=1 CANONICAL=Q9TTK4-1" }, "isoforms": [ { "isoform_ac": "Q9TTK4-1", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4/entry#Q9TTK4-1", "sequence": { "sequence": "MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQEEKATDFNLPFSAGIILTKEKNSSSQRSTQEKLYLEGSAPAGQVSAKVNVFRKSRRQRKTTHRYSVRDARKTQLSTSDSEVNSDDKSIVMTKYRRSHVLQHFVKQCPKEDHLTAKLNHLSTKEQTPPDTMALENSREIIPREESNTDILSEPAALSTISHMNNSPFDLCHVLLSLLEKVCKFDITLNHNSALAASVVPTLTEFLAGFGDCCNLSDNLEGQMVSAGWTEEPVALIQRMLFRTVLHLMSVDISMAEVMPENLRKNLTELLRAALKIRTFLEKQPDPFAPRQKKTLQEVQDDFVFSKYCHRVLLLPELLEGVLQILICCLQSAASNPFFFSQAMDLVQEFIQHHGFHLFETAVLQMEWLVVRDGVPPEASGHLKALINNVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGDVYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVQNIGICCCMDPKSVIVPLLHAFKLPALKSCQQHILNILNKLILDQLGGAEIPQKTKKAACNICTVDSDQLAKLEETLQGSSYNAEPSSGLSSPSYRFQGILPSSGSEDLLWKWDALEAYQNFVFEEDRLQSVQIANHICSLIQKGNVVVQWKLYNCIFNPVLQRGVELAHHCQQLSISSAQTHVCSHHNQCLPQEVLQIYLKTLPTLLKSRVIRDLFLSCNGVNQIIELNYLDGIRNHSLKAFETLIISLGEQQKDSSIPGIDGIDLEQKELSSLNVGTLYNQQAYSDSQSLSKFYARLKDAYPKKRKSVVQDIHISTINLFLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLQHMLPCFSLESLVLPSPRHMHQAADVWSMCRWIYMLSPIFRKQFYRLGGFQVCHKLIFMVIQDLFRNPEEEQGRKEGDRTMNENQDLNRISQPEITVKEDLLSLTVKIDPTPTELSSLKKSADSLGRLESEHLSSINVEQIPAVEAVPEETKVFMSRESETLLQGIRLLEALLAICLHGTRASQQKLELELPNQNLSVETILLEMRDHLSKSKVTETELAKPLFDALLRVALGNHSADFEHDDAMTEKSHQSEEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDSETWDDGVDLKPEAESFIASSSPNDLLENLSQGEIIYPEICTLELNLLSTGKAKLDVLAHVFESFLKIIRQKEKNIFLLMQQGTVKNLLGGFLSILTQTDSDFQACQRVLVDLLVSLMSSRTCSEELTLLLRIFLEKSPCTEILLLGILKIVESDITMSPSQYLTFPLLHTPNLSNGVSSQKCPGILNSKAMGLLRRARVSQSKKEGDSESFPQQLLSSWHIAPVHLPLLGQPHLSEGFSISLWFNVECIHEPESTTEKGKKTRKRNKSLVLLDSSFDGTENNRLEGAAYVNPGERLIEEGCVHMISLGSKALIIQVWADPHTGTFIFRVCMDSNDDTKVVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKKNIHGKISIWISGQRKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEESLQLAGKWDLGNLLLFNGAKIGSQEAFYLYACGPNHTSIMPCKYGKPVNDYSKYINTEILQCEQIRELFMTSKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVHNILLEPHHLKNLQPTECKTLQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRIHELENCNGLSMIHQVLIKQKCIVGFHILKTLLEGCCGEDIIHINENGELKLDVESNAIIQDVKLLEELLLDWKIWNKAEHGVWETLLAALEVLIRADHQQQMFNIKQLLKARVVHHFLLTCQVLQEHKEGQLISMPQEVCRSFVKITAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVQSIMYLRHSSSGGKSVTSPGFMIISPSDFTASPPEGNNSSSAVPKQVTASMLRSRSLPAFPTASPHIKPRKLTGSLGCSIDKLQSFVDDGVASQPEKWSPLRSSETLEKSKQDAFISSCESAKMVCETEPALLAQASVSDIPKGALELPAVNIDHKDFGAEPRSDDDSPGDESCPRRPLYLKGLASFQRSHSTIASLGLAFPSQNGSAAVGRWPSLVDRNADDWENFALSLGYEPHHSRTAGAHSVTEDCLVPICCGLYELLSGVLLILPDVMLEDVMDRLIQADTLLVLVNHPSPAVQQEVIKLLDAYFNRASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMFFGRRIGLDEEFDLEDVKNMGLFQKWSVIPILGLIETSLYDNVLLHNALLLLLQILNSCSKVADMLLDNGLLYVLCNTVATLNGLEKIIPLNEYRLLACDIQQLFIAVTIHACSSSGSQYFRVIEDLIVLLGYLQNSKNKRTQNMAVALQFRVLQAAMEFIRTTANHDSENLTDSLQSPSVPHHTMFQKRKSIAGPRKFLLAQTDSLLMKMRSVASDELHVMMQRRMSQENPVQATETELAQRLQRLTVFAVNRIVYQEFNPDIIDILSTPESTTQSRTSASQTEISEENIHHEQPSVFNPFQKEMFMYLVEGFKVSSASGKTSSSKQQWAKILWSCKETFRMQLGRLLVHMLSPAHPSQERKQIFEIVREPNHQEILRECLSPSLQHGAKLVLYLSELIHNHKDELTEEELDTAELLMNALKLCGHKCIPPSASTKSDLIRVIKEEQRKYETEEGVNKANWQKTVNNNQQSLFQRLDSKSKDISKIAADITQAVSLSQGIERKKVIQHIRGMYKVDLSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCYLTIPNKYLLRDRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVECSNLQGELEPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRNDVYHSILTNNLPNLLEYGNITALTHLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLSDPSVYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFQSAHASRPGSKLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQSEPPINFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYSNRFTSGTPSEIEMESQIHLYGHTEEISSLFVCKPYSIMISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETTGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGISINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIVSLTFSCDGHHLYTANSDGTVIAWCRKDQQRLKHPMFYSFLSSYAAG", "length": 3796, "header": "sp|Q9TTK4-1|LYST_BOVIN Isoform 1 of Lysosomal-trafficking regulator OS=Bos taurus OX=9913 GN=LYST PE=1 SV=1 CANONICAL=Q9TTK4-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1046, "start_aa": "Thr", "end_pos": 1046, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1046", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [ { "start_pos": 1504, "end_pos": 1504, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK4", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4" } ], "site_lbl": "Ser1504" }, { "start_pos": 1505, "end_pos": 1505, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK4", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4" } ], "site_lbl": "Ser1505" }, { "start_pos": 164, "end_pos": 164, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK4", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4" } ], "site_lbl": "Ser164" }, { "start_pos": 165, "end_pos": 165, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK4", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4" } ], "site_lbl": "Thr165" }, { "start_pos": 166, "end_pos": 166, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK4", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4" } ], "site_lbl": "Ser166" }, { "start_pos": 2100, "end_pos": 2100, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK4", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4" } ], "site_lbl": "Ser2100" }, { "start_pos": 2119, "end_pos": 2119, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK4", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4" } ], "site_lbl": "Ser2119" }, { "start_pos": 2208, "end_pos": 2208, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK4", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4" } ], "site_lbl": "Ser2208" }, { "start_pos": 2212, "end_pos": 2212, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK4", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4" } ], "site_lbl": "Ser2212" }, { "start_pos": 2259, "end_pos": 2259, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK4", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4" } ], "site_lbl": "Ser2259" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Cloning of bovine LYST gene and identification of a missense mutation associated with Chediak-Higashi syndrome of cattle.", "journal": "Mammalian genome : official journal of the International Mammalian Genome Society", "date": "1999-12", "authors": "Kunieda T, Nakagiri M, Takami M, Ide H, Ogawa H", "evidence": [ { "database": "UniProtKB", "id": "Q9TTK4", "url": "https://www.uniprot.org/uniprotkb/Q9TTK4" } ], "reference": [ { "type": "PubMed", "id": "10594238", "url": "https://glygen.org/publication/PubMed/10594238" } ] }, { "title": "Chediak-Higashi syndrome mutation and genetic testing in Japanese black cattle (Wagyu).", "journal": "Anim. 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"categories": [ "Protein Classification" ] }, { "id": "PF00048", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00048", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-380108", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380108", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418594", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_991342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991342", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9TTS6", "url": "https://www.uniprot.org/uniprotkb/Q9TTS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9TTS6-1", "url": "https://www.uniprot.org/uniprotkb/Q9TTS6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"glytoucan_ac": "", "type": "O-linked", "subtype": "O-GalNAcylation", "prediction_tool_list": [], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "T", "relation": "attached", "comment": "O-linked (GalNAc...) threonine;O-GalNAcylation", "icn3d_view": {}, "start_pos": 94, "start_aa": "Thr", "end_pos": 94, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr94", "evidence": [ { "id": "Q9TTS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTS6#ptm_processing" } ], "filter_code": "000000000000000010000.00000010000000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Bovine eotaxin (CCL11)--an unusual member of the eotaxin group--attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary.", "journal": "Veterinary immunology and immunopathology", "date": "2005-08-15", "authors": "Vogel B, Klinder A, Sittig D, Aust G", 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griseus", "sequence": { "sequence": "MQISTVLLGLLLVATAFTSQVLAHPGSIPASCCFVMANKKIPKPLLKNYKKITNSRCTLKAIIFRTKLGKDICADPKQKWVQDAIKHLDQILQTPKP", "length": 97 }, "evidence": [ { "id": "Q9TTS6", "url": "https://omabrowser.org/oma/group/Q9TTS6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A4X1T9Y7-1", "protein_name": "C-C motif chemokine", "gene_name": "CCL11", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQVSAALLCLLLTAAAFSTQVLAQPASVATICCFNVTRKKIPIQRLQSYQRVTANKCPQNAVIFSTRQAKKICADAQENWVQNAMEYLDQKSKTVKS", "length": 97 }, "evidence": [ { "id": "Q9TTS6", "url": "https://omabrowser.org/oma/group/Q9TTS6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0AB32T986-1", "protein_name": "C-C motif chemokine", "gene_name": "ccl38a.3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKPSCNFIACLVLATFCLVNGSQGPVKCCYSFFNARIPVKEVGGYHATHLQCNINAVIFITKAQREICTNPAEKWVQRLMRLVDVQNMKQMTEGRIGDSLDTHRSKPLHEMPKTNQAVSKKAEIITMTEMPLQQQDETTSILYYFQDWTDFDTTQANSKTDEHTNATSRWSQIHPSWIIINTGSLTAGTHQKERHIRQAHARGR", "length": 204 }, "evidence": [ { "id": "Q9TTS6", "url": "https://omabrowser.org/oma/group/Q9TTS6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P48298-1", "protein_name": "Eotaxin", "gene_name": "Ccl11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQSSTALLFLLLTVTSFTSQVLAHPGSIPTSCCFIMTSKKIPNTLLKSYKRITNNRCTLKAIVFKTRLGKEICADPKKKWVQDATKHLDQKLQTPKP", "length": 97 }, "evidence": [ { "id": "Q9TTS6", "url": "https://omabrowser.org/oma/group/Q9TTS6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P51671-1", "protein_name": "Eotaxin", "gene_name": "CCL11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"GO:0001938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001938", "evidence": [ { "database": "UniProtKB", "id": "Q9TTS6", "url": "https://www.uniprot.org/uniprotkb/Q9TTS6" } ], "pmid": "" }, { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "Q9TTS6", "url": "https://www.uniprot.org/uniprotkb/Q9TTS6" } ], "pmid": "" }, { "name": "positive regulation of actin filament polymerization", "id": "GO:0030838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030838", "evidence": [ { "database": "UniProtKB", "id": "Q9TTS6", "url": "https://www.uniprot.org/uniprotkb/Q9TTS6" } ], "pmid": "" }, { "name": "negative regulation of neurogenesis", "id": "GO:0050768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050768", "evidence": [ { "database": "UniProtKB", "id": "Q9TTS6", "url": "https://www.uniprot.org/uniprotkb/Q9TTS6" } ], "pmid": "" }, { "name": "eosinophil chemotaxis", "id": 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{ "database": "PubMed", "id": "19565634", "url": "https://glygen.org/publication/PubMed/19565634" } ] }, { "annotation": "Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. 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"categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-373076", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373076", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001035628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035628", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9TTY5", "url": "https://www.uniprot.org/uniprotkb/Q9TTY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9TTY5-1", "url": "https://www.uniprot.org/uniprotkb/Q9TTY5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPNNSFRVDSEFRYTLFPIFYSIVFVLGVIANSYVLWVFARLYPSKKFNEIKIFMVNLTMADLLFLVTLPLWIVYYYNQGDWILPKFLCNLAGCFFFINTYCSVAFLAVITYNRFQAVTRPIKTAQATTRKRGILLSLIIWVSIVGAASYFFVLDSTNREPNKTGSANITRCFEHYEKGSIPVLTIHIFLVFSFFLVFLIILFCNLVIIRTLLTQQVQIQRNAEVKRRALWMVCTVLAVFIICFVPHHLVQLPWTLAELGFQDTDFHQAINDAHQVTLCLLSTNCVLDPIIYCFLTKKFRKHLTEKLYSMRESRKCSRATSETGTEVVMQLKDVPVKSLKY", "length": 342, "header": "sp|Q9TTY5-1|PTAFR_BOVIN Isoform 1 of Platelet-activating factor receptor OS=Bos taurus OX=9913 GN=PTAFR PE=1 SV=2 CANONICAL=Q9TTY5-1" }, "isoforms": [ { "isoform_ac": "Q9TTY5-1", "url": "https://www.uniprot.org/uniprotkb/Q9TTY5/entry#Q9TTY5-1", "sequence": { "sequence": 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} ] }, { "title": "Fluorometric detection of platelet activating factor receptor in cultured oviductal epithelial and stromal cells and endometrial stromal cells from bovine at different stages of the oestrous cycle and early pregnancy.", "journal": "Domest. Anim. Endocrinol.", "date": "2001", "authors": "Tiemann U, Viergutz T, Jonas L, Wollenhaupt K, P\u00f6hland R, Kanitz W", "evidence": [ { "database": "UniProtKB", "id": "Q9TTY5", "url": "https://www.uniprot.org/uniprotkb/Q9TTY5" } ], "reference": [ { "type": "PubMed", "id": "11438398", "url": "https://glygen.org/publication/PubMed/11438398" } ] }, { "title": "Comparison of the coding sequence of the platelet-activating factor receptor gene in three species.", "journal": "DNA Seq.", "date": "2001", "authors": "Yang W, Diehl J R, Roudebush W E", "evidence": [ { "database": "UniProtKB", "id": "Q9TTY5", "url": "https://www.uniprot.org/uniprotkb/Q9TTY5" } ], "reference": [ { "type": "PubMed", "id": "11916258", "url": "https://glygen.org/publication/PubMed/11916258" } ] }, { "title": "Role of the platelet-activating factor and its receptor in the proliferative regulation of bovine ovarian granulosa cells.", "journal": "Cell proliferation", "date": "2007-12", "authors": "Viergutz T, L\u00f6hrke B", "evidence": [ { "database": "RefSeq", "id": "NP_001035628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035628" } ], "reference": [ { "type": "PubMed", "id": "18021181", "url": "https://glygen.org/publication/PubMed/18021181" } ] }, { "title": "Platelet-activating factor-stimulated production of reactive oxygen species in ovarian granulosa cells from periovulatory follicles.", "journal": "Cytometry. Part A : the journal of the International Society for Analytical Cytology", "date": "2009-08", "authors": "Xu Jinxian, Kr\u00fcger Burkhard, Vernunft Andreas, L\u00f6hrke Berthold, Viergutz Torsten", "evidence": [ { "database": "RefSeq", "id": "NP_001035628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035628" } ], "reference": [ { "type": "PubMed", "id": "19565634", "url": "https://glygen.org/publication/PubMed/19565634" } ] } ], "pathway": [ { "id": "bta:518283", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518283", "resource": "KEGG Pathway" }, { "id": "R-BTA-373076", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373076", "resource": "Reactome", "description": "Class A/1 (Rhodopsin-like receptors)" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C095-1", "protein_name": "Platelet-activating factor receptor", "gene_name": "PTAFR", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSGEGKGDAAGSVCPIDSEFRYSLFTVFYSIIFILGFVANCYVLWIFSRIYPTKKLNEIKIFMLNLTVADLLFLVTMPLWIVYYHNHGNWIMPKFLCSVAGSLFFVNTYASVAFLMVITYNRYQAVTNPIRAAQFTTQRRGIFLSAAIWIITVGSALYYIFDDNTNVEKIDSINYTRCFERYDSTGNVTPVLAIHIIICTLFYVIFLFILTWNIIIIRTLFSKSGQQRKSAHVKQRALWMVCTVLVVFIISFVPHHIVDLPWTLTVLEQWKKENCHLRQQLNDAHQVTLCLLSMNCVLDPVIYCFLTKKFQKHVSQNLKSMKGSRKCSRQTTDTVIEGTIHQEDAIGF", "length": 348 }, "evidence": [ { "id": "Q9TTY5", "url": "https://omabrowser.org/oma/group/Q9TTY5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7EZR6-1", "protein_name": "Platelet-activating factor receptor", "gene_name": "ptafr", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MENMSSTKWTENTNDTEIIDSRFRYTLFPIFYGVVFVLGLIANCYALYVLHRMRESKAMNEIRIYMTNLTVADLLFVSALPFWIDYYMHEGHWRSTEAFCRITGTFFFINTYGSILFLTVISINRYWAVTKPLKAASSDCWKRGAIISVLIWAFILSASIPQLTKEGIQKEQRMNRSMQRCFEGYHYTDENTKNVLVITHFSIIGLFFLVFLMVIICNISIARALLSQPISQPRASTGRRPGGTKRRALRMLCAVIGVFVICFLPHHVVQGPWVLSVLQLKKYWSTWTHQTLNDAHQITLMLMGINCLLDPLVYCFATTKFRKYLENHFTKMKNRKNCSRYTLSTGISLKSRHQSIVNAVDEEKA", "length": 365 }, "evidence": [ { "id": "Q9TTY5", "url": "https://omabrowser.org/oma/group/Q9TTY5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3H1Z5-1", "protein_name": "Platelet-activating factor receptor", "gene_name": "Ptafr", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEQNESFRVDSEFRYTLFPTVYSVIFILGVVANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYYNEGNWILPKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLVIWISIVATASYFLATDSTNLVRKKDGSGNITRCFEHYEPRSVPILVVHVFIAFCFFLVFFLILYCNLVIIHTLLTRPMRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYNMRSSRKCSRATTDTGTEVMMPADQTPVMSLKN", "length": 341 }, "evidence": [ { "id": "Q9TTY5", "url": "https://omabrowser.org/oma/group/Q9TTY5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P25105-1", "protein_name": "Platelet-activating factor receptor", "gene_name": "PTAFR", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN", "length": 342 }, "evidence": [ { "id": "Q9TTY5", "url": "https://omabrowser.org/oma/group/Q9TTY5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P46002-1", "protein_name": "Platelet-activating factor receptor", "gene_name": "Ptafr", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN", "length": 341 }, "evidence": [ { "id": "Q9TTY5", "url": "https://omabrowser.org/oma/group/Q9TTY5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q62035-1", "protein_name": "Platelet-activating factor receptor", "gene_name": "Ptafr", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN", "length": 341 }, "evidence": [ { "id": "Q9TTY5", "url": "https://omabrowser.org/oma/group/Q9TTY5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9TTY5", "url": "https://www.uniprot.org/uniprotkb/Q9TTY5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q9TTY5", "url": "https://www.uniprot.org/uniprotkb/Q9TTY5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "chemotaxis", "id": "GO:0006935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006935", "evidence": [ { "database": "UniProtKB", "id": "Q9TTY5", "url": "https://www.uniprot.org/uniprotkb/Q9TTY5" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "Q9TTY5", "url": "https://www.uniprot.org/uniprotkb/Q9TTY5" } ], "pmid": "" }, { "name": "female pregnancy", "id": "GO:0007565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007565", "evidence": [ { "database": "UniProtKB", "id": "Q9TTY5", "url": "https://www.uniprot.org/uniprotkb/Q9TTY5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled purinergic nucleotide receptor activity", "id": "GO:0045028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045028", "evidence": [ { "database": "UniProtKB", "id": "Q9TTY5", "url": "https://www.uniprot.org/uniprotkb/Q9TTY5" } ], "pmid": "" }, { "name": "platelet activating factor receptor activity", "id": "GO:0004992", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004992", "evidence": [ { "database": "UniProtKB", "id": "Q9TTY5", "url": "https://www.uniprot.org/uniprotkb/Q9TTY5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" }, { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9TTY5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 342, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9TTY5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9TTY5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 4, 163, 169 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 163, "end_pos": 165 }, { "start_pos": 169, "end_pos": 171 }, { "start_pos": 4, "end_pos": 6 }, { "start_pos": 58, "end_pos": 60 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 3 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_n_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "Q9TU03-1", "uniprot_ac": "Q9TU03", "uniprot_id": "GDIR2_BOVIN", "mass": { "chemical_mass": 22794.0, "monoisotopic_mass": 22794.0 }, "refseq": { "ac": "NP_786991", "name": "rho GDP-dissociation inhibitor 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786991" }, "gene_names": [ { "name": "ARHGDIB", "type": "recommended", "evidence": [ { "id": "Q9TU03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU03" } ] }, { "name": "ARHGDIB", "type": "synonym", "evidence": [ { "id": "NP_786991", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786991" } ] }, { "name": "GDID4", "type": "synonym", "evidence": [ { "id": "Q9TU03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU03" } ] } ], "protein_names": [ { "name": "Rho GDP-dissociation inhibitor 2", "type": "recommended", "evidence": [ { "id": "Q9TU03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU03/entry#names_and_taxonomy" } ] }, { "name": "D4-GDI", "type": "synonym", "evidence": [ { "id": "NP_786991", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786991" }, { "id": "Q9TU03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU03/entry#names_and_taxonomy" } ] }, { "name": "D4-GDP-dissociation inhibitor", "type": "synonym", "evidence": [ { "id": "NP_786991", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786991" }, { "id": "Q9TU03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU03/entry#names_and_taxonomy" } ] }, { "name": "Ly-GDI", "type": "synonym", "evidence": [ { "id": "Q9TU03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU03/entry#names_and_taxonomy" } ] }, { "name": "Rho GDI 2", "type": "synonym", "evidence": [ { "id": "Q9TU03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU03/entry#names_and_taxonomy" } ] }, { "name": "Rho GDP dissociation inhibitor (GDI) beta", "type": "synonym", "evidence": [ { "id": "NP_786991", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786991" } ] }, { "name": "Rho-GDI beta", "type": "synonym", "evidence": [ { "id": "Q9TU03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TU03/entry#names_and_taxonomy" } ] }, { "name": "ly-GDI", "type": "synonym", "evidence": [ { "id": "NP_786991", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786991" } ] }, { "name": "rho GDI 2", "type": "synonym", "evidence": [ { "id": "NP_786991", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786991" } ] }, { "name": "rho GDP-dissociation inhibitor 2", "type": "synonym", "evidence": [ { "id": "NP_786991", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786991" } ] }, { "name": "rho-GDI beta", "type": "synonym", "evidence": [ { "id": "NP_786991", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786991" } ] } ], "function": [ { "annotation": "Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members.", "evidence": [ { "database": "UniProtKB", "id": "Q9TU03", "url": "https://www.uniprot.org/uniprotkb/Q9TU03#function" }, { "database": "UniProtKB", "id": "P52566", "url": "https://www.uniprot.org/uniprotkb/P52566#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9TU03", "url": "https://www.uniprot.org/uniprotkb/Q9TU03" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARHGDIB", "url": "https://www.uniprot.org/uniprotkb/Q9TU03", "locus": {} } ], "crossref": [ { "id": "Q9TU03", "url": "https://alphafold.ebi.ac.uk/entry/Q9TU03", "database": "AlphaFoldDB", "categories": [] }, { "id": "327676", "url": "https://www.ncbi.nlm.nih.gov/gene/327676", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000406", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000406", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024792", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024792", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:327676", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:327676", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q9TU03", "url": "https://www.orthodb.org/?gene=Q9TU03", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10980", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10980", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10980:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10980:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02115", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02115", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_786991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786991", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9TU03", "url": "https://www.uniprot.org/uniprotkb/Q9TU03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9TU03-1", "url": "https://www.uniprot.org/uniprotkb/Q9TU03-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTEKAPEPHVEEDDDELDGKLNYKPPPQKSLKELQEMDKDDESLTKYKKTLLGDGPVVADPTAPNVTVTRLTLVCESAPGPITMDLTGDLEALKKETFVLKEGVEYRVKINFKVNKDIVSGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPIEEAPKGMLARGTYHNKSFFTDDDKHDHLTWEWNLSIKKDWTE", "length": 200, "header": "sp|Q9TU03-1|GDIR2_BOVIN Isoform 1 of Rho GDP-dissociation inhibitor 2 OS=Bos taurus OX=9913 GN=ARHGDIB PE=2 SV=3 CANONICAL=Q9TU03-1" }, "isoforms": [ { "isoform_ac": "Q9TU03-1", "url": "https://www.uniprot.org/uniprotkb/Q9TU03/entry#Q9TU03-1", "sequence": { "sequence": "MTEKAPEPHVEEDDDELDGKLNYKPPPQKSLKELQEMDKDDESLTKYKKTLLGDGPVVADPTAPNVTVTRLTLVCESAPGPITMDLTGDLEALKKETFVLKEGVEYRVKINFKVNKDIVSGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPIEEAPKGMLARGTYHNKSFFTDDDKHDHLTWEWNLSIKKDWTE", "length": 200, "header": "sp|Q9TU03-1|GDIR2_BOVIN Isoform 1 of Rho GDP-dissociation inhibitor 2 OS=Bos taurus OX=9913 GN=ARHGDIB PE=2 SV=3 CANONICAL=Q9TU03-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 144, "end_pos": 144, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9TU03", "url": "https://www.uniprot.org/uniprotkb/Q9TU03" } ], "site_lbl": "Ser144" }, { "start_pos": 23, "end_pos": 23, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q9TU03", "url": "https://www.uniprot.org/uniprotkb/Q9TU03" } ], "site_lbl": "Tyr23" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Cloning of bovine low molecular weight GTPases (Rac1 and Rac2) and Rho GDP-dissociation inhibitor 2 (D4-GDI).", "journal": "Vet. Immunol. 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Classification" ] }, { "id": "IPR018933", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018933", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282069", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282069", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GGQHYDY", "url": "https://omabrowser.org/oma/group/GGQHYDY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "Q9XSC1", "url": "https://www.orthodb.org/?gene=Q9XSC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11309", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11309", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11309:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11309:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01392", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01392", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01759", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01759", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_776886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776886", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9XSC1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9XSC1-1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRAAAGGARAAVLALLLGALHGAPARGEEYDYYGWQTEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKSGPLKRKDTKRLVLHMKNSAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH", "length": 315, "header": "sp|Q9XSC1-1|SFRP5_BOVIN Isoform 1 of Secreted frizzled-related protein 5 OS=Bos taurus OX=9913 GN=SFRP5 PE=2 SV=1 CANONICAL=Q9XSC1-1" }, "isoforms": [ { "isoform_ac": "Q9XSC1-1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1/entry#Q9XSC1-1", "sequence": { "sequence": "MRAAAGGARAAVLALLLGALHGAPARGEEYDYYGWQTEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKSGPLKRKDTKRLVLHMKNSAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH", "length": 315, "header": "sp|Q9XSC1-1|SFRP5_BOVIN Isoform 1 of Secreted frizzled-related protein 5 OS=Bos taurus OX=9913 GN=SFRP5 PE=2 SV=1 CANONICAL=Q9XSC1-1" }, "locus": { "chromosome": "26", "start_pos": 18919167, "end_pos": 18915100, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024709.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024709.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024709.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024709.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium.", "journal": "Hum. Mol. Genet.", "date": "1999", "authors": "Chang J T, Esumi N, Moore K, Li Y, Zhang S, Chew C, Goodman B, Rattner A, Moody S, Stetten G, Campochiaro P A, Zack D J", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1" } ], "reference": [ { "type": "PubMed", "id": "10072424", "url": "https://glygen.org/publication/PubMed/10072424" } ] } ], "pathway": [ { "id": "bta:282069", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282069", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZTV6-1", "protein_name": "Secreted frizzled-related protein 5", "gene_name": "Sfrp5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRVAGGARTAALALLLGALHGAPARGQEYDYYGWQTEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEIEHSADGLMEQMCSSDFVVKMRIKEIKIDNGDRKLIGAQKKKKLLKAGPLKRKDTKKLVLHMKNGASCPCPQLDNLTGSFLVMGRKVEGQLLLTAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH", "length": 314 }, "evidence": [ { "id": "Q9XSC1", "url": "https://omabrowser.org/oma/group/Q9XSC1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NM64-1", "protein_name": "Secreted frizzled-related protein 5", "gene_name": "SFRP5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPRASGPTGTVTLALLALALAPGEGQHYDYYGWQPESVPRGRFYGREPQCVDIPADMQLCHDVGYKRMRLPNLLEHESMAEAKQQASSWVPLLAKQCHADTQLFLCSLFAPVCLDRPIYPCRSLCEVVRDACAPVMESYGFPWPEMLHCGKFPSDHDLCIAVQFGNNQATPPPVPKICTQCEMEHKADGMMQQMCSSDFVVKMRIKEVIEENGEKRLVAAQKKKVLKLGPLKRKDTKKMVLHMRNTGSCPCPQLANLSGSFLVLGRKVGSRLLLLAIYPWQKHNKEMKFAVKFMFSYPCPLYHPLLYGAGQH", "length": 312 }, "evidence": [ { "id": "Q9XSC1", "url": "https://omabrowser.org/oma/group/Q9XSC1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S8X3-1", "protein_name": "Secreted frizzled-related protein 5", "gene_name": "SFRP5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRAAARGARAAALALLLGALHGAPAHGEEYDYYGWQTEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRLKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH", "length": 315 }, "evidence": [ { "id": "Q9XSC1", "url": "https://omabrowser.org/oma/group/Q9XSC1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5T4F7-1", "protein_name": "Secreted frizzled-related protein 5", "gene_name": "SFRP5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRAAAAGGGVRTAALALLLGALHWAPARCEEYDYYGWQAEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH", "length": 317 }, "evidence": [ { "id": "Q9XSC1", "url": "https://omabrowser.org/oma/group/Q9XSC1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9WU66-1", "protein_name": "Secreted frizzled-related protein 5", "gene_name": "Sfrp5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWVAWSARTAALALLLGALHGAPTRGQEYDYYGWQAEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAARAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIDNGDRKLIGAQKKKKLLKAGPLKRKDTKKLVLHMKNGASCPCPQLDNLTGSFLVMGRKVEGQLLLTAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH", "length": 314 }, "evidence": [ { "id": "Q9XSC1", "url": "https://omabrowser.org/oma/group/Q9XSC1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1" } ], "pmid": "" }, { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1" } ], "pmid": "" }, { "name": "digestive tract morphogenesis", "id": "GO:0048546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048546", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1" } ], "pmid": "" }, { "name": "negative regulation of Wnt signaling pathway", "id": "GO:0030178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030178", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1" } ], "pmid": "" }, { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1" } ], "pmid": "" }, { "name": "negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051898", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1" } ], "pmid": "" }, { "name": "negative regulation of non-canonical Wnt signaling pathway", "id": "GO:2000051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000051", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1" } ], "pmid": "" }, { "name": "non-canonical Wnt signaling pathway", "id": "GO:0035567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035567", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "Wnt-protein binding", "id": "GO:0017147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017147", "evidence": [ { "database": "UniProtKB", "id": "Q9XSC1", "url": "https://www.uniprot.org/uniprotkb/Q9XSC1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], 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"id": "NP_777185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777185" }, { "id": "Q9XSI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSI3/entry#names_and_taxonomy" } ] }, { "name": "Protein QM homolog", "type": "synonym", "evidence": [ { "id": "Q9XSI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSI3/entry#names_and_taxonomy" } ] }, { "name": "Ribosomal protein L10", "type": "synonym", "evidence": [ { "id": "Q9XSI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSI3/entry#names_and_taxonomy" } ] }, { "name": "protein QM homolog", "type": "synonym", "evidence": [ { "id": "NP_777185", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777185" } ] } ], "function": [ { "annotation": "Component of the large ribosomal subunit. 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"Gene Expression" ] }, { "id": "cd01433", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01433", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "286790", "url": "https://www.ncbi.nlm.nih.gov/gene/286790", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018255", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018255", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047873", "database": 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"url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_777185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777185", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9XSI3", "url": "https://www.uniprot.org/uniprotkb/Q9XSI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9XSI3-1", "url": "https://www.uniprot.org/uniprotkb/Q9XSI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFENMVAEKRLIPDGCGVKYIPNRGPLDKWRALHS", "length": 214, "header": "sp|Q9XSI3-1|RL10_BOVIN Isoform 1 of Large ribosomal subunit protein uL16 OS=Bos taurus OX=9913 GN=RPL10 PE=2 SV=4 CANONICAL=Q9XSI3-1" }, "isoforms": [ { "isoform_ac": "Q9XSI3-1", "url": "https://www.uniprot.org/uniprotkb/Q9XSI3/entry#Q9XSI3-1", "sequence": { "sequence": "MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFENMVAEKRLIPDGCGVKYIPNRGPLDKWRALHS", "length": 214, "header": "sp|Q9XSI3-1|RL10_BOVIN Isoform 1 of Large ribosomal subunit protein uL16 OS=Bos taurus OX=9913 GN=RPL10 PE=2 SV=4 CANONICAL=Q9XSI3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The ribosomal protein QM is expressed differentially during vertebrate endochondral bone development.", "journal": "J. Bone Miner. Res.", "date": "2000", "authors": "Green H, Canfield A E, Hillarby M C, Grant M E, Boot-Handford R P, Freemont A J, Wallis G A", "evidence": [ { "database": "UniProtKB", "id": "Q9XSI3", "url": "https://www.uniprot.org/uniprotkb/Q9XSI3" } ], "reference": [ { "type": "PubMed", "id": "10841175", "url": "https://glygen.org/publication/PubMed/10841175" } ] }, { "title": "Characterization of 954 bovine full-CDS cDNA sequences.", "journal": "BMC Genomics", "date": "2005", "authors": "Harhay Gregory P, Sonstegard Tad S, Keele John W, Heaton Michael P, Clawson Michael L, Snelling Warren M, Wiedmann Ralph T, Van Tassell Curt P, Smith Timothy P L", "evidence": [ { "database": "UniProtKB", "id": "Q9XSI3", "url": "https://www.uniprot.org/uniprotkb/Q9XSI3" } ], "reference": [ { "type": "PubMed", "id": "16305752", "url": "https://glygen.org/publication/PubMed/16305752" } ] } ], "pathway": [ { "id": "bta:286790", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286790", "resource": "KEGG Pathway" }, { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "O61231-1", "protein_name": "Large ribosomal subunit protein uL16", "gene_name": "RpL10", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGRRPARCYRYCKNKPYPKSRFCRGVPDPKIRIFDLGRKKATVEDFPLCVHLVSDEYEQLSSEALEAGRICCNKYLVKYCGKDQFHIRMRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVRIGQPIMSVRSSDRYKAQVIEALRRAKFKFPGRQKIYVSKKWGFTKYERERYEELRDDNRLEPDGCNVKYRPEHGPIAAWEKAQRDVYA", "length": 218 }, "evidence": [ { "id": "Q9XSI3", "url": "https://omabrowser.org/oma/group/Q9XSI3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P41805-1", "protein_name": "Large ribosomal subunit protein uL16", "gene_name": "RPL10", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MARRPARCYRYQKNKPYPKSRYNRAVPDSKIRIYDLGKKKATVDEFPLCVHLVSNELEQLSSEALEAARICANKYMTTVSGRDAFHLRVRVHPFHVLRINKMLSCAGADRLQQGMRGAWGKPHGLAARVDIGQIIFSVRTKDSNKDVVVEGLRRARYKFPGQQKIILSKKWGFTNLDRPEYLKKREAGEVKDDGAFVKFLSKKGSLENNIREFPEYFAAQA", "length": 221 }, "evidence": [ { "id": "Q9XSI3", "url": "https://omabrowser.org/oma/group/Q9XSI3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q29195-1", "protein_name": "Large ribosomal subunit protein uL16", "gene_name": "RPL10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFENMVAEKRLIPDGCGVKYIPNRGPLDKWRALHS", "length": 214 }, "evidence": [ { "id": "Q9XSI3", "url": "https://omabrowser.org/oma/group/Q9XSI3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54J69-1", "protein_name": "Large ribosomal subunit protein uL16", "gene_name": "rpl10", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MGRRPARCYRYCKNKPYIKSRYCRGVPDAKIRIFDLGRKKASTDEFPLCVHLISLEKEQLSSEAIEAGRISCNKYISKTGGKDSFHMRVRVHPWHVLRINKMLSCAGADRLQTGMRGAFGKPMGTVARVNIGQIIFSIRTRDNMLANVVEALRRSSYKFPGRQKIVVSKKWGFTAYNREAYQKLKADGRLMNDGANVKVITNHGTLAQYAKDIAAAN", "length": 217 }, "evidence": [ { "id": "Q9XSI3", "url": "https://omabrowser.org/oma/group/Q9XSI3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6PDV7-1", "protein_name": "Large ribosomal subunit protein uL16", "gene_name": "Rpl10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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Synergizes with IL2 in regulating interferon-gamma synthesis. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Also functions on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils. Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6. Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (By similarity). Induces inflammatory response in esophageal epithelium which results in a dysregulation of desmosome intercellular adhesion junctions, via down-regulation of DSG1 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9XSV9", "url": "https://www.uniprot.org/uniprotkb/Q9XSV9#function" }, { "database": "UniProtKB", "id": "P20109", "url": "https://www.uniprot.org/uniprotkb/P20109#function" }, { "database": "UniProtKB", "id": "P42203", "url": "https://www.uniprot.org/uniprotkb/P42203#function" }, { "database": "UniProtKB", "id": "P35225", "url": "https://www.uniprot.org/uniprotkb/P35225#function" } ] }, { "annotation": "T helper (Th) type 2 cell cytokine IL-13 modulates airway contraction by secreting matrix metalloproteinase-1 from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.", "evidence": [ { "database": "RefSeq", "id": "NP_776514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776514" }, { "database": "PubMed", "id": "18322231", "url": "https://glygen.org/publication/PubMed/18322231" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9XSV9", "url": "https://www.uniprot.org/uniprotkb/Q9XSV9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL13", "url": "https://www.uniprot.org/uniprotkb/Q9XSV9", "locus": { "chromosome": "7", "start_pos": 21720745, "end_pos": 21723568, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015953", "url": "https://www.ensembl.org/id/ENSBTAG00000015953" } ] } } ], "crossref": [ { "id": "Q9XSV9", "url": "https://alphafold.ebi.ac.uk/entry/Q9XSV9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015953", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015953", "database": "Bgee", 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"https://www.uniprot.org/uniprotkb/Q9XSV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9XSV9-1", "url": "https://www.uniprot.org/uniprotkb/Q9XSV9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALLLTAVIVLICFGGLTSPSPVPSATALKELIEELVNITQNQKVPLCNGSMVWSLNLTSSMYCAALDSLISISNCSVIQRTKRMLNALCPHKPSAKQVSSEYVRDTKIEVAQFLKDLLRHSRIVFRNERFN", "length": 132, "header": "sp|Q9XSV9-1|IL13_BOVIN Isoform 1 of Interleukin-13 OS=Bos taurus OX=9913 GN=IL13 PE=2 SV=2 CANONICAL=Q9XSV9-1" }, "isoforms": [ { "isoform_ac": "Q9XSV9-1", "url": "https://www.uniprot.org/uniprotkb/Q9XSV9/entry#Q9XSV9-1", "sequence": { "sequence": "MALLLTAVIVLICFGGLTSPSPVPSATALKELIEELVNITQNQKVPLCNGSMVWSLNLTSSMYCAALDSLISISNCSVIQRTKRMLNALCPHKPSAKQVSSEYVRDTKIEVAQFLKDLLRHSRIVFRNERFN", "length": 132, "header": "sp|Q9XSV9-1|IL13_BOVIN Isoform 1 of Interleukin-13 OS=Bos taurus OX=9913 GN=IL13 PE=2 SV=2 CANONICAL=Q9XSV9-1" }, "locus": { "chromosome": "7", "start_pos": 21723498, 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"url": "https://www.uniprot.org/uniprotkb/Q9XSV9" } ], "reference": [ { "type": "PubMed", "id": "10436181", "url": "https://glygen.org/publication/PubMed/10436181" } ] }, { "title": "Dual modulation of airway smooth muscle contraction by Th2 cytokines via matrix metalloproteinase-1 production.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2008-03-15", "authors": "Ohta Yoshinori, Hayashi Masayuki, Kanemaru Takaaki, Abe Kihachiro, Ito Yushi, Oike Masahiro", "evidence": [ { "database": "RefSeq", "id": "NP_776514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776514" } ], "reference": [ { "type": "PubMed", "id": "18322231", "url": "https://glygen.org/publication/PubMed/18322231" } ] } ], "pathway": [ { "id": "bta:281247", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281247", "resource": "KEGG Pathway" }, { "id": "R-BTA-6785807", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6785807", "resource": "Reactome", "description": 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"common_name": "Human" }, { "uniprot_canonical_ac": "P42203-1", "protein_name": "Interleukin-13", "gene_name": "Il13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALWVTAVLALACLGGLATPGPVRRSTSPPVALRELIEELSNITQDQKTSLCNSSMVWSVDLTAGGFCAALESLTNISSCNAIHRTQRILNGLCNQKASDVASSPPDTKIEVAQFISKLLNYSKQLFRYGH", "length": 131 }, "evidence": [ { "id": "Q9XSV9", "url": "https://omabrowser.org/oma/group/Q9XSV9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q95J68-1", "protein_name": "Interleukin-13", "gene_name": "IL13", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALWLTLVIALTCFGGLASPGPVPPHSTALKELIEELVNITQNQKTPLCNGSMVWSVNLTTSMQYCAALESLINISDCSAIQKTQRMLSALCSHKPPSEQVPGKHIRDTKIEVAQFVKDLLKHLRMIFRHG", "length": 131 }, "evidence": [ { "id": "Q9XSV9", "url": "https://omabrowser.org/oma/group/Q9XSV9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ 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] }, { "name": "Post-proline cleaving enzyme", "type": "synonym", "evidence": [ { "id": "Q9XTA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XTA2/entry#names_and_taxonomy" } ] }, { "name": "post-proline cleaving enzyme", "type": "synonym", "evidence": [ { "id": "NP_777197", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777197" } ] }, { "name": "prolyl endopeptidase", "type": "synonym", "evidence": [ { "id": "NP_777197", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777197" } ] }, { "name": "prolyl oligopeptidase", "type": "synonym", "evidence": [ { "id": "NP_777197", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777197" } ] } ], "function": [ { "annotation": "Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.", "evidence": [ { "database": "UniProtKB", "id": "Q9XTA2", "url": "https://www.uniprot.org/uniprotkb/Q9XTA2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "Q9XTA2", "url": "https://www.uniprot.org/uniprotkb/Q9XTA2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PREP", "url": "https://www.uniprot.org/uniprotkb/Q9XTA2", "locus": { "chromosome": "9", "start_pos": 44708594, "end_pos": 44576094, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016281", "url": "https://www.ensembl.org/id/ENSBTAG00000016281" } ] } } ], "crossref": [ { "id": "Q9XTA2", "url": "https://alphafold.ebi.ac.uk/entry/Q9XTA2", "database": "AlphaFoldDB", "categories": [] }, { "id": "CHEMBL2460", "url": "https://www.ebi.ac.uk/chembl/target/inspect/CHEMBL2460", "database": "ChEMBL", "categories": [ "Chemical" ] }, { "id": "286818", "url": "https://www.ncbi.nlm.nih.gov/gene/286818", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002470", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002470", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002471", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002471", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051167", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051167", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:286818", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286818", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q9XTA2", "url": "https://www.orthodb.org/?gene=Q9XTA2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42881", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42881", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42881:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42881:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00326", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00326", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02897", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02897", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PR:Q9XTA2", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:Q9XTA2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_777197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777197", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9XTA2", "url": "https://www.uniprot.org/uniprotkb/Q9XTA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9XTA2-1", "url": "https://www.uniprot.org/uniprotkb/Q9XTA2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSFQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCNFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVCLDPNTLSDDGTVALRGYAFSEDGEYVAYGLSASGSDWVTIKFMKVDGAKELADVLERVKFSCMAWTHDGKGMFYNAYPQQDGKSDGTETSTNLHQKLCYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLHQEPNGITGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRHSPNYRLINIDFTDPEESRWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNTLQLHDMATGALLKTFPLEVGSVVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVCRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDNKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSPKFIATLQHLVGRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIDWIQ", "length": 710, "header": "sp|Q9XTA2-1|PPCE_BOVIN Isoform 1 of Prolyl endopeptidase OS=Bos taurus OX=9913 GN=PREP PE=2 SV=1 CANONICAL=Q9XTA2-1" }, "isoforms": [ { "isoform_ac": "Q9XTA2-1", "url": "https://www.uniprot.org/uniprotkb/Q9XTA2/entry#Q9XTA2-1", "sequence": { "sequence": "MLSFQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCNFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVCLDPNTLSDDGTVALRGYAFSEDGEYVAYGLSASGSDWVTIKFMKVDGAKELADVLERVKFSCMAWTHDGKGMFYNAYPQQDGKSDGTETSTNLHQKLCYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLHQEPNGITGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRHSPNYRLINIDFTDPEESRWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNTLQLHDMATGALLKTFPLEVGSVVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVCRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDNKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSPKFIATLQHLVGRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIDWIQ", "length": 710, "header": "sp|Q9XTA2-1|PPCE_BOVIN Isoform 1 of Prolyl endopeptidase OS=Bos taurus OX=9913 GN=PREP PE=2 SV=1 CANONICAL=Q9XTA2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Cloning and expression of the cDNA encoding prolyl oligopeptidase (prolyl endopeptidase) from bovine brain.", "journal": "Biol. Pharm. Bull.", "date": "1997", "authors": "Yoshimoto T, Miyazaki K, Haraguchi N, Kitazono A, Kabashima T, Ito K", "evidence": [ { "database": "UniProtKB", "id": "Q9XTA2", "url": "https://www.uniprot.org/uniprotkb/Q9XTA2" } ], "reference": [ { "type": "PubMed", "id": "9353562", "url": "https://glygen.org/publication/PubMed/9353562" } ] } ], "pathway": [ { "id": "bta:286818", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:286818", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "Q9XTA2", "url": "https://www.uniprot.org/uniprotkb/Q9XTA2" } ], "pmid": "" }, { "name": "oligopeptidase activity", "id": "GO:0070012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070012", "evidence": [ { "database": "UniProtKB", "id": "Q9XTA2", "url": "https://www.uniprot.org/uniprotkb/Q9XTA2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9XTA2", "url": "https://www.uniprot.org/uniprotkb/Q9XTA2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9XTA2", "url": "https://www.uniprot.org/uniprotkb/Q9XTA2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "Q9XTA2", "url": "https://www.uniprot.org/uniprotkb/Q9XTA2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 477, "end_pos": 479, "annotation": "n_glycosylation_sequon" }, { "start_pos": 483, "end_pos": 485, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-Q9XTA2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 710, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-Q9XTA2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/Q9XTA2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.21.26", "ec_name": "Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.", "evidence": [ { "id": "3.4.21.26", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.21.26" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 477, "end_pos": 479 }, { "start_pos": 483, "end_pos": 485 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"protein_names": [ { "name": "B-cell CLL/lymphoma 9 protein", "type": "recommended", "evidence": [ { "id": "E1BPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPF3/entry#names_and_taxonomy" } ] }, { "name": "B-cell CLL/lymphoma 9 protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024845746", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845746" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPF3", "url": "https://www.uniprot.org/uniprotkb/E1BPF3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BCL9", "url": "https://www.uniprot.org/uniprotkb/E1BPF3", "locus": { "chromosome": "3", "start_pos": 22002301, "end_pos": 22017702, "strand": "+", "evidence": [ { "database": 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Pathway" ] }, { "id": "ECNSTEH", "url": "https://omabrowser.org/oma/group/ECNSTEH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPF3", "url": "https://www.orthodb.org/?gene=E1BPF3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15185", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15185", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15185:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15185:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11502", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11502", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-201722", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201722", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024845746", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845746", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8P9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8P9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8P9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8P9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPF3", "url": "https://www.uniprot.org/uniprotkb/E1BPF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPF3-1", "url": "https://www.uniprot.org/uniprotkb/E1BPF3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHSSNPKVRNSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDSDMKECNSADHIKSQDSQHTPHSMTPSNATVPRSSTPSHGQTTAPEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNSKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRDSPGVENKLIPSVGSPAGSTPLPPDSTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFPGGQSGGPQQNTGVLDGPQKKPEGPIQAMMVQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGPIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPGEAWGPGGSEPFADGINMPHSLPPRAMAPHPNMPGSQMRLPGFAGMMNSEMEGPNVPNPASRPGLSAVSWPDDVPKIPDGRNFPPGQGVFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMSVEGIRPGMEMNRMIPGSQRHVEPGNNPIFPRIPVEGPLSPSRGDFPKGMPPQLGPGRELEFGMVPSGMKGDVSLNVSMGSNSQMIPQKMREAGAGPEEMLKLRAGGADMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPMGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPVDISVAGSQVHSPGINPLKSPTMRQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLASVESGGPPPPTASQSASVSIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAMGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGNFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFAVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF", "length": 1426, "header": "tr|E1BPF3-1|E1BPF3_BOVIN Isoform 1 of B-cell CLL/lymphoma 9 protein OS=Bos taurus OX=9913 GN=BCL9 PE=3 SV=3 CANONICAL=E1BPF3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M8P9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8P9/entry", "sequence": { "sequence": "MRMGRREQASGLSESSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDSDMKECNSADHIKSQDSQHTPHSMTPSNATVPRSSTPSHGQTTAPEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNSKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRDSPGVENKLIPSVGSPAGSTPLPPDSTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFPGGQSGGPQQNTGVLDGPQKKPEGPIQAMMVQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGPIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPGEAWGPGGSEPFADGINMPHSLPPRAMAPHPNMPGSQMRLPGFAGMMNSEMEGPNVPNPASRPGLSAVSWPDDVPKIPDGRNFPPGQGVFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMSVEGIRPGMEMNRMIPGSQRHVEPGNNPIFPRIPVEGPLSPSRGDFPKGMPPQLGPGRELEFGMVPSGMKGDVSLNVSMGSNSQMIPQKMREAGAGPEEMLKLRAGGADMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPMGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPVDISVAGSQVHSPGINPLKSPTMRQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLASVESGGPPPPTASQSASVSIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAMGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGNFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFAVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF", "length": 1423, "header": "tr|A0A3Q1M8P9-1|E1BPF3_BOVIN Computationally mapped isoform of B-cell CLL/lymphoma 9 protein OS=Bos taurus OX=9913 GN=BCL9 PE=3 SV=1 CANONICAL=E1BPF3-1" }, "locus": { "chromosome": "3", "start_pos": 22016604, "end_pos": 22003305, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080372.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080372.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064833.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064833.2" } ] } }, { "isoform_ac": "E1BPF3-1", "url": "https://www.uniprot.org/uniprotkb/E1BPF3/entry", "sequence": { "sequence": "MHSSNPKVRNSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDSDMKECNSADHIKSQDSQHTPHSMTPSNATVPRSSTPSHGQTTAPEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNSKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRDSPGVENKLIPSVGSPAGSTPLPPDSTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFPGGQSGGPQQNTGVLDGPQKKPEGPIQAMMVQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGPIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPGEAWGPGGSEPFADGINMPHSLPPRAMAPHPNMPGSQMRLPGFAGMMNSEMEGPNVPNPASRPGLSAVSWPDDVPKIPDGRNFPPGQGVFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMSVEGIRPGMEMNRMIPGSQRHVEPGNNPIFPRIPVEGPLSPSRGDFPKGMPPQLGPGRELEFGMVPSGMKGDVSLNVSMGSNSQMIPQKMREAGAGPEEMLKLRAGGADMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPMGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPVDISVAGSQVHSPGINPLKSPTMRQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLASVESGGPPPPTASQSASVSIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAMGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGNFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFAVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF", "length": 1426, "header": "tr|E1BPF3-1|E1BPF3_BOVIN Isoform 1 of B-cell CLL/lymphoma 9 protein OS=Bos taurus OX=9913 GN=BCL9 PE=3 SV=3 CANONICAL=E1BPF3-1" }, "locus": { "chromosome": "3", "start_pos": 22017442, "end_pos": 22003305, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003141.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003141.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003141.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003141.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 155, "start_aa": "Thr", "end_pos": 155, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr155", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 167, "start_aa": "Thr", "end_pos": 167, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr167", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 257, "start_aa": "Thr", "end_pos": 257, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr257", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 315, "start_aa": "Thr", "end_pos": 315, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr315", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 974, "start_aa": "Thr", "end_pos": 974, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr974", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:788729", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788729", "resource": "KEGG Pathway" }, { "id": "R-BTA-201722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201722", "resource": "Reactome", "description": "Formation of the beta-catenin:TCF transactivating complex" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PQ44-1", "protein_name": "B-cell CLL/lymphoma 9 protein", "gene_name": "BCL9", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MHSSNPKVRNSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSTSQSQPSPCDPKSGGHPPKVLPGPGGSMGLKNGAGNGAKGKGKRERSISADSFEQREAGTPNDDPEIKDCNSADHVKSQDSQHTPHSMTPSNASAPRSSTPSHGLTAALEPASGQKTPSKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNSKVERNTVPLNPQINALRTEPKPLPQPQPPAAQDQNPPQNAKMQPTPPVSAPVSKSTGPPCPIDQDSPSVESKVMSVGSPANSTPLQTEGFGQSSTPNNRAVSPVSQGSNSSAADPKGPPQQVSGGDPSSLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFAGGQSGGPPPNSGVMDGPQKKPEGPIQAMMAQSQSLGKGSGSRTDGGAPFGPQGHRDMPFSPDEMGPPPMNSQSGPIGPDHLDHMTPEQVAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPGEGWGPGGPEPFPEGMNMSHSLPPRGMAPHPNMPGSQMRLPGFAGMMNPDMEGPNVPNPASRPGLSGVNWPDDVPKIPDGRNFPPGQGVFSGPGRGERFPNPQGLPEEIYQQQLAEKQMGLPPGLNMEGIRPGMEINRMIASQRHMEPGNNPIFPRMPVEGPMSPSRGDFPKGMPPQMSSGRELEFGMGPGGMKGDMGMNVSMGSNPPLVPQKLREAGVGPEEMMKLRPGVSEMLSSQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGVGLRNLREQMGPDQRTNNRLSHMPPLPLNPTSNPNSLNTAPPAQRSLGRKPLDISAAGQVHSPGINPLKSPTMRQVQSPMMGSPSGNLKSPQTPSQLAGMLAGPTAAAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKASLTMSSPAMLGNVESGGPPPSTVSQPAPVTLPGNLPSSSPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPPMNSVPGMGINSQNPRISGPNPVGPMPTLSPMGMTQPLSHNNQMPSPNAMGPNIPPHGVPVGPGLMSHNPMMGHGSQESPMVPQGRLGFPQGFPPVQSPPQQVPFPHNGPSGGQGNFPAGMGFHGEGPLGRPTNLPQSSTDPALCKTGGPGGPDSFTVLGNNMPSVFTDPELQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMIGEQTPRMGLTLPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQTAMPGQPALMSNPVAAVGMIPGKDRAPAGLYSHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF", "length": 1422 }, "evidence": [ { "id": "E1BPF3", "url": "https://omabrowser.org/oma/group/E1BPF3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8I6GB32-1", "protein_name": "B-cell CLL/lymphoma 9 protein", "gene_name": "Bcl9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHPSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKPGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDSDIKECNSADHIKSQESQHTPHSMTPSTATAPRSSTPSHGQTPAPEPIPAQKTPAKVVYVFSTEMANKAADAVLKGQVETIVSFHIQNISNSKTERSTAPLNTQIPSLRNDPKPLPQQPPAPASQDQNSSQNARLQPTPPIQAPAPKPAAAPRPLDRDSPGVENKLIPPVGSPGSSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTAGQTGGPQQNTGVLDGPQKKPEGPIQAMMSQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGPIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMAPGEGWAPGAEPFPDGINISHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGVFSGPGRGDRFPNPQGLSEEMFQQQLAEKQLALPPGMSMEGIRPGMEMNRMIPGSQRHMEPGSNPIFPRIPVEGPLSPSRGDFPKGMPPQIGPGRELEFGMVPGGMKGDVSLNVNMGSSSQMIPQKMREAGAGPEEMMKLRPGSSEMLPAQQKMVPLPFGEHPQQEYGVGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLSTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGSVESGGPPPPTASQPASVSIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNSMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSTQMPSPNAMGPSIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPTGGQGNFPGGIGFPGEGPLGRPSNLPQSSADPALCKPGGPGAPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMSDQAPRMGLALPGMGGPGPVGTPDIPLGTSPSMPGHSPMRPPAFLQQGMMGPHHRMMSPAQSTVPGPATLMTNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF", "length": 1425 }, "evidence": [ { "id": "E1BPF3", "url": "https://omabrowser.org/oma/group/E1BPF3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A9J7F2N3-1", "protein_name": "B-cell CLL/lymphoma 9 protein", "gene_name": "Bcl9", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKPGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDSDIKECNSADHIKSQDSQHTPHSMTPSTATAPTSSTPSHGQTTAPDPIPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNSKTERSTAPLNTQIPTLRNDPKPLPQQPPAPTNQDQNSSQNARLQPTPPIQAPAPKPAAAPRSLDRDSPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTAGQTGGPQPNTGVLDGPQKKPEGPIQAMMSQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQPGPIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMAPSEGWAPGAEPFPDGINISHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPSQGVFSGPGRGERFPNPQGLSEEMFQQQLAEKQLALPPGMSMEAIRPGMEMNRMIPGSQRHMEPGSNPIFPRIPVEGPLSPSRGDFPKGMPPQIGPGRELEFGMVPGGMKGDVSLNVSMGSSSQMIPQKMREAGAGPEEMMKLRPGSSDMLPAQQKMVPLPFGEHPPQEYGVGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPAQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKTPLTMASPAMLGSVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAMGPSIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPAGGQGNFPGGIGFPGEGPLGRPSNLPQSTADAALCKPGGPGAPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMSDQAPRMGLALPGMGGPGPVGTPDIPLGTSPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQAALMTNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF", "length": 1425 }, "evidence": [ { "id": "E1BPF3", "url": "https://omabrowser.org/oma/group/E1BPF3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O00512-1", "protein_name": "B-cell CLL/lymphoma 9 protein", "gene_name": "BCL9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDSDIKECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF", "length": 1426 }, "evidence": [ { "id": "E1BPF3", "url": "https://omabrowser.org/oma/group/E1BPF3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D219-1", "protein_name": "B-cell CLL/lymphoma 9 protein", "gene_name": "Bcl9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHPSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQGKPGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERSISADSFDQRDPGTPNDDSDIKECNSADHIKSQESQHTPHSMTPSTATAPRSSTPSHGQTPAPEPISAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNSKSERSTAPLNTQIPTLRNDPKPLPQQPPAPANQDQNSSQNARLQPTPPIQAPAPKPTAAPRPLDRESPGVENKLIPPVGSPGSSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSGGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTAGQTGGPQQNTGVLDGPQKKPDGPIQAMMSQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPNMSSQSGPIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQMAPGEGWAPGAEPFPDGINISHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGVFSGPGRGERFPNPQGLSEEMFQQQLAEKQLALPPGMSMEGIRPGMEMNRMIPGSQRHMEPGSNPIFPRIPVEGPLSPSRGDFPKGMPPQIGPGRELEFGMVPGGMKGEVNLNVNMGSSSQMIPQKMREAGAGPEEMMKLRPGSSEMLPAQQKMVPLPFGEHPQQEYGVGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLSTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGSVESGGPPPPTASQPASVNIPGSLPSSTPYPMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNSMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAMGPSIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPTGGQGNFPGGIGFPGEGPLGRPSNLPQSSADPALCKPGGPGAPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMSDQAPRMGLALPGMGGPGPVGTPDIPLGTSPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTVPGPATLMTNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF", "length": 1425 }, "evidence": [ { "id": "E1BPF3", "url": "https://omabrowser.org/oma/group/E1BPF3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "E1BPF3", "url": "https://www.uniprot.org/uniprotkb/E1BPF3" } ], "pmid": "" }, { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "E1BPF3", "url": "https://www.uniprot.org/uniprotkb/E1BPF3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BPF3", "url": "https://www.uniprot.org/uniprotkb/E1BPF3" } ], "pmid": "" }, { "name": "cis-Golgi network", "id": "GO:0005801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005801", "evidence": [ { "database": "UniProtKB", "id": "E1BPF3", "url": "https://www.uniprot.org/uniprotkb/E1BPF3" } ], "pmid": "" }, { "name": "beta-catenin-TCF complex", "id": "GO:1990907", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990907", "evidence": [ { "database": "UniProtKB", "id": "E1BPF3", "url": "https://www.uniprot.org/uniprotkb/E1BPF3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "E1BPF3", "url": "https://www.uniprot.org/uniprotkb/E1BPF3" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "E1BPF3", "url": "https://www.uniprot.org/uniprotkb/E1BPF3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 322, "end_pos": 324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 723, "end_pos": 725, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPF3" }, { "id": "PF11502", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11502" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B-cell lymphoma 9 beta-catenin binding", "eco_id": "ECO_0000259", "start_pos": 350, "end_pos": 388, "start_aa": "Gly", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 155, 167, 257, 315, 974 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 147, "end_pos": 149 }, { "start_pos": 207, "end_pos": 209 }, { "start_pos": 247, "end_pos": 249 }, { "start_pos": 306, "end_pos": 308 }, { "start_pos": 322, "end_pos": 324 }, { "start_pos": 723, "end_pos": 725 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BP63-1", "uniprot_ac": "E1BP63", "uniprot_id": "E1BP63_BOVIN", "mass": { "chemical_mass": 71090.0, "monoisotopic_mass": 71090.0 }, "refseq": {}, "gene_names": [ { "name": "RNF139", "type": "recommended", "evidence": [ { "id": "E1BP63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase RNF139", "type": "recommended", "evidence": [ { "id": "E1BP63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP63/entry#names_and_taxonomy" } ] }, { "name": "RING finger protein 139", "type": "synonym", "evidence": [ { "id": "E1BP63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP63/entry#names_and_taxonomy" } ] }, { "name": "RING-type E3 ubiquitin transferase RNF139", "type": "synonym", "evidence": [ { "id": "E1BP63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP63/entry#names_and_taxonomy" } ] }, { "name": "Translocation in renal carcinoma on chromosome 8 protein", "type": "synonym", "evidence": [ { "id": "E1BP63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP63/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNF139", "url": "https://www.uniprot.org/uniprotkb/E1BP63", "locus": { "chromosome": "14", "start_pos": 15591660, "end_pos": 15616858, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020399", "url": "https://www.ensembl.org/id/ENSBTAG00000020399" } ] } } ], "crossref": [ { "id": "E1BP63", "url": "https://alphafold.ebi.ac.uk/entry/E1BP63", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020399", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020399", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16683", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16683", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025754", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025754", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050731", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050731", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BP63", "url": "https://www.orthodb.org/?gene=E1BP63", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22763", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22763", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22763:SF163", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22763:SF163", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13639", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13639", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13705", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13705", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RYX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP63-1", "url": "https://www.uniprot.org/uniprotkb/E1BP63-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METCLEWYQNGSREMGMFVSSIVLILSQRSLFKFYMYSSAFLLAATSVLVNYYAALHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYITLLQIHSIYSQLIILDLLVPVIGLITELPLHIRETLVFTSSLILTLNTVLVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDVLRVFWLTRITAQATVLIYILRMANETDSFFLSWDDFWDLICNLIISGCDSTLTVLGMSAVISSIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSLRRHFPVLFVSACLFILPVILSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGNIIEFIFGVVMFGNGAYTMMFESGSKIRACMMCLHAYFNIYLQAKNGWKTFMNRRTAVKKINSLPEIKGSRLQEIDDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNTNTSNNNGFIAPNENPEEAVREAAAESDRELNEDDSTDCDDDAQRERNGVIQHTGTAAEELINDDTD", "length": 620, "header": "tr|E1BP63-1|E1BP63_BOVIN Isoform 1 of E3 ubiquitin-protein ligase RNF139 OS=Bos taurus OX=9913 GN=RNF139 PE=4 SV=4 CANONICAL=E1BP63-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYX6/entry", "sequence": { "sequence": "MFVSSIVLILSQRSLFKFYMYSSAFLLAATSVLVNYYAALHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYITLLQIHSIYSQLIILDLLVPVIGLITELPLHIRETLVFTSSLILTLNTVLVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDVLRVFWLTRITAQATVLIYILRMANETDSFFLSWDDFWDLICNLIISGCDSTLTVLGMSAVISSIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSLRRHFPVLFVSACLFILPVILSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGNIIEFIFGVVMFGNGAYTMMFESGSKIRACMMCLHAYFNIYLQAKNGWKTFMNRRTAVKKINSLPEIKGSRLQEIDDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNTNTSNNNGFIAPNENPEEAVREAAAESDRELNEDDSTDCDDDAQRERNGVIQHTGTAAEELINDDTD", "length": 604, "header": "tr|A0AAA9RYX6-1|E1BP63_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase RNF139 OS=Bos taurus OX=9913 GN=RNF139 PE=4 SV=1 CANONICAL=E1BP63-1" }, "locus": { "chromosome": "14", "start_pos": 15595136, "end_pos": 15593325, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097036.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097036.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076502.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076502.1" } ] } }, { "isoform_ac": "E1BP63-1", "url": "https://www.uniprot.org/uniprotkb/E1BP63/entry", "sequence": { "sequence": "METCLEWYQNGSREMGMFVSSIVLILSQRSLFKFYMYSSAFLLAATSVLVNYYAALHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYITLLQIHSIYSQLIILDLLVPVIGLITELPLHIRETLVFTSSLILTLNTVLVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDVLRVFWLTRITAQATVLIYILRMANETDSFFLSWDDFWDLICNLIISGCDSTLTVLGMSAVISSIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSLRRHFPVLFVSACLFILPVILSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGNIIEFIFGVVMFGNGAYTMMFESGSKIRACMMCLHAYFNIYLQAKNGWKTFMNRRTAVKKINSLPEIKGSRLQEIDDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNTNTSNNNGFIAPNENPEEAVREAAAESDRELNEDDSTDCDDDAQRERNGVIQHTGTAAEELINDDTD", "length": 620, "header": "tr|E1BP63-1|E1BP63_BOVIN Isoform 1 of E3 ubiquitin-protein ligase RNF139 OS=Bos taurus OX=9913 GN=RNF139 PE=4 SV=4 CANONICAL=E1BP63-1" }, "locus": { "chromosome": "14", "start_pos": 15616659, "end_pos": 15593325, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027187.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027187.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027187.7", "url": "https://www.ensembl.org/id/ENSBTAP00000027187.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" }, { "name": "protease binding", "id": "GO:0002020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002020", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" }, { "name": "Derlin-1 retrotranslocation complex", "id": "GO:0036513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036513", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "regulation of ER to Golgi vesicle-mediated transport", "id": "GO:0060628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060628", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" }, { "name": "negative regulation of translation", "id": "GO:0017148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" }, { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" }, { "name": "protein destabilization", "id": "GO:0031648", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031648", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" }, { "name": "positive regulation of ubiquitin-dependent protein catabolic process", "id": "GO:2000060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000060", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" }, { "name": "regulation of protein processing", "id": "GO:0070613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070613", "evidence": [ { "database": "UniProtKB", "id": "E1BP63", "url": "https://www.uniprot.org/uniprotkb/E1BP63" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" }, { "start_pos": 216, "end_pos": 218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 555, "end_pos": 557, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BP63-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 620, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BP63-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BP63" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BP63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP63" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 502, "end_pos": 541, "start_aa": "Cys", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 }, { "start_pos": 216, "end_pos": 218 }, { "start_pos": 555, "end_pos": 557 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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{ "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BP10-1", "uniprot_ac": "E1BP10", "uniprot_id": "E1BP10_BOVIN", "mass": { "chemical_mass": 167504.0, "monoisotopic_mass": 167504.0 }, "refseq": { "ac": "XP_002698459", "name": "slit homolog 1 protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698459" }, "gene_names": [ { "name": "SLIT1", "type": "recommended", "evidence": [ { "id": "E1BP10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP10" } ] }, { "name": "SLIT1", "type": "synonym", "evidence": [ { "id": "XP_002698459", 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During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.", "evidence": [ { "database": "UniProtKB", "id": "E1BP10", "url": "https://www.uniprot.org/uniprotkb/E1BP10#function" }, { "database": "UniProtKB", "id": "ARBA00059139", "url": "https://www.uniprot.org/uniprotkb/ARBA00059139#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP10", "url": "https://www.uniprot.org/uniprotkb/E1BP10" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLIT1", "url": "https://www.uniprot.org/uniprotkb/E1BP10", "locus": { "chromosome": "26", "start_pos": 18272313, "end_pos": 18444236, "strand": "+", "evidence": [ { "database": 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"Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050541", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050541", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051355", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051355", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510761", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510761", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ETKCQNN", "url": "https://omabrowser.org/oma/group/ETKCQNN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BP10", "url": "https://www.orthodb.org/?gene=E1BP10", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24369:SF196", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24369:SF196", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45836", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45836", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45836:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45836:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01462", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01462", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01463", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01463", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02210", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02210", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002698459", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698459", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8E8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8E8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP10", "url": "https://www.uniprot.org/uniprotkb/E1BP10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP10-1", "url": "https://www.uniprot.org/uniprotkb/E1BP10-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALTPPRGPSALLVRPALWLLLWAAAWRLGATGCPALCTCAGTTVDCHGTGLRAVPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGVVERGAFDDMKELERLRLNRNLLHTLPELLFQNNQALSRLDLSENTIQAIPRKAFRGATDLKNLQLDKNQIGCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPAGLRGLNVAEVQKSEFSCSGQGEAGRTPSCTLSSGSCPAMCACSNGIVDCRGKGLTAIPANLPEAMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQISEIAPDAFQGLRSLNSLVLYGNKITDLPQGVFGGLFTLQLLLLNANKINCIRLDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRSNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGAEDYQLNSECNSDVVCPHKCRCEASMVECSSLKLTKIPERVPQATAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLEGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQIATISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWLRKRKIVTGNPRCQNPDFLRQIPLQDVASPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLQTLPKGIPKNVTELYLDGNQFTLVPAQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNSLQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPLDMEGKLLLTTPAKKFECQGPPTLTVQAKCDPCLSSPCQNQGTCRNDPLVGYRCACPSGYKGRDCEVSLDSCSSSPCGNGGTCRSQEGEDAGFTCSCPTGFEGPTCGVDTDDCVEHSCANGGTCVDGVGSYTCQCPLQYSGRACELLVDFCAPDLNPCQHEAQCVGTPDGPRCECAPGYAGGNCTEKQDDCRDHRCQNGAQCVDEANGYSCLCTQGYSGQLCETPPRPPGPRSPCEGTECQNGANCVDQGNGPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSTETINDGQFHTVELVTFDQMVNLSIDGGSPMTMDNFGKHYTLNSDAPLYVGGMPVDVNSAAFRLWQILNGTSFHGCIRNLYINNELQDFTKTRMKPGVVPGCEPCRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPADGPCHGHKCVHGKCVPLDALSYSCQCQDGYSGALCNQAGAPADPCEGLRCLHGHCQASATKGTYCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICRTTRPLSWVECRGSCPGQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA", "length": 1534, "header": "tr|E1BP10-1|E1BP10_BOVIN Isoform 1 of Slit homolog 1 protein OS=Bos taurus OX=9913 GN=SLIT1 PE=4 SV=3 CANONICAL=E1BP10-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8E8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E8/entry", "sequence": { "sequence": "MALTPPRGPSALLVRPALWLLLWAAAWRLGATGCPALCTCAGTTVDCHGTGLRAVPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGVVERGAFDDMKELERLRLNRNLLHTLPELLFQNNQALSRLDLSENTIQAIPRKAFRGATDLKNLQLDKNQIGCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPAGLRGLNVAEVQKSEFSCSGQGEAGRTPSCTLSSGSCPAMCACSNGIVDCRGKGLTAIPANLPEAMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQISEIAPDAFQGLRSLNSLHTSCPLGPPGTYLAPAVPSSKRDLKEIARCFYSDG", "length": 397, "header": "tr|A0AAA9S8E8-1|E1BP10_BOVIN Computationally mapped isoform of Slit homolog 1 protein OS=Bos taurus OX=9913 GN=SLIT1 PE=4 SV=1 CANONICAL=E1BP10-1" }, "locus": { "chromosome": "26", "start_pos": 18444037, "end_pos": 18325600, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130114.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130114.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079618.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079618.1" } ] } }, { "isoform_ac": "E1BP10-1", "url": "https://www.uniprot.org/uniprotkb/E1BP10/entry", "sequence": { "sequence": "MALTPPRGPSALLVRPALWLLLWAAAWRLGATGCPALCTCAGTTVDCHGTGLRAVPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGVVERGAFDDMKELERLRLNRNLLHTLPELLFQNNQALSRLDLSENTIQAIPRKAFRGATDLKNLQLDKNQIGCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPAGLRGLNVAEVQKSEFSCSGQGEAGRTPSCTLSSGSCPAMCACSNGIVDCRGKGLTAIPANLPEAMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQISEIAPDAFQGLRSLNSLVLYGNKITDLPQGVFGGLFTLQLLLLNANKINCIRLDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRSNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGAEDYQLNSECNSDVVCPHKCRCEASMVECSSLKLTKIPERVPQATAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLEGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQIATISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWLRKRKIVTGNPRCQNPDFLRQIPLQDVASPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLQTLPKGIPKNVTELYLDGNQFTLVPAQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNSLQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPLDMEGKLLLTTPAKKFECQGPPTLTVQAKCDPCLSSPCQNQGTCRNDPLVGYRCACPSGYKGRDCEVSLDSCSSSPCGNGGTCRSQEGEDAGFTCSCPTGFEGPTCGVDTDDCVEHSCANGGTCVDGVGSYTCQCPLQYSGRACELLVDFCAPDLNPCQHEAQCVGTPDGPRCECAPGYAGGNCTEKQDDCRDHRCQNGAQCVDEANGYSCLCTQGYSGQLCETPPRPPGPRSPCEGTECQNGANCVDQGNGPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSTETINDGQFHTVELVTFDQMVNLSIDGGSPMTMDNFGKHYTLNSDAPLYVGGMPVDVNSAAFRLWQILNGTSFHGCIRNLYINNELQDFTKTRMKPGVVPGCEPCRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPADGPCHGHKCVHGKCVPLDALSYSCQCQDGYSGALCNQAGAPADPCEGLRCLHGHCQASATKGTYCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICRTTRPLSWVECRGSCPGQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA", "length": 1534, "header": "tr|E1BP10-1|E1BP10_BOVIN Isoform 1 of Slit homolog 1 protein OS=Bos taurus OX=9913 GN=SLIT1 PE=4 SV=3 CANONICAL=E1BP10-1" }, "locus": { "chromosome": "26", "start_pos": 18444037, "end_pos": 18272511, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061296.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061296.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053488.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053488.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1001, "start_aa": "Thr", "end_pos": 1001, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1001", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1357, "start_aa": "Thr", "end_pos": 1357, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1357", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510761", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510761", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z8V4-1", "protein_name": "Slit homolog 1 protein", "gene_name": "SLIT1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVPPGAASTSGGAAGVPAALRAAAWLLAFVALCRGRAAACPPLCACSGTTVDCHGTALRAVPKSIPRGTERLELNGNNITRIHKNDFSGLKQLRVLQLMENQISVVERGAFDDMKELERLRLNRNQLHTLPELLFQHNQALSRLDLSENFIQAIPRKAFRGATDLKNLQLDKNQISCIEDGAFRALRGLEVLTLNNNNITSIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLAQWLRQRPTIGLFTQCAAPAQLRGLNVAEIQKNEFSCSGQADGVHAQLCSLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYKKLRRIDLSNNQISEIAPDAFQGLRSLNSLVLYGNKITDLPKGVFGGLFALQLLLLNANKINCVRADAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFVCDCNLKWLADFLRANPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPPKCRCEAGVVECSNLKLTKIPERIPQSTAELRLNNNEISILEATGVFKKLPHLKKINLSNNKVSEIEDGAFEGAASVSELHLTVNQLESVRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQISTIAPGAFDTLQSLSTLNLLANPFNCNCQLAWLGDWLRKRKIVTGNPRCQHPDFLRQIPLQDVAFPDFRCEEGQEETSCIPRPQCPQECTCLDTVVRCSNKHLKALPRGIPKNVTELYLDGNQFTQVPGQLSTFKYLQLVDLSNNRISSLSNSSFTNMSQLTTLILSYNSLQCIPPLAFEGLRSLRLLSLHGNDISTLPEGIFADVTSLSHLAIGANPLYCSCNLRWLSSWVKTGYKEPGIARCAGPPDMEGKLLLTTPAKKFECQGPPSLIVQAKCNPCLSSPCRNQGTCHNDPLGSYRCACPIGYKGRDCEVALDGCSQNPCANGGTCQPQDGDRDGFRCLCAAGFEGPSCRTASDPCKEHSCENGGSCVAAATNYTCLCPAHYTGDFCEQPPDFCSAELSPCQHGSTCIPTSQGPRCECAPGYVGTNCSKDFDDCQDHRCQNNARCVDEVNGYSCLCAEGYSGQLCEMPPHAAGQPGLCERAECQNGAACVERGSRALCQCLPGFGGPKCEKLLSVNFVDRDTYLQFTDLQDWPRANITLQVSTAEDNGILLYNGDSDHMAVELYQGHVRVSYDPGTHPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGGSPMTMDNSGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQLLNGTSFHGCIRNLYINNELQDFTKTRMTPGVVPGCEPCRKLYCLHGICQPTGAQGPVCHCEPGWDGPHCDQPRGGPCQGHKCVHGLCLPLDALSYSCQCHQGYQGALCNQPSTPPDPCRLLSCHHGRCRLTPGGQPVCECHSGYSGTLCDQEPECHGEPVRDYHQVQRGYAICQTTRPVPYVQCRGTCGGDTDTGCCIGLRPRRRKYAFECSNGATFVEEVEKPSKCGCSPCL", "length": 1544 }, "evidence": [ { "id": "E1BP10", "url": "https://omabrowser.org/oma/group/E1BP10/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O75093-1", "protein_name": "Slit homolog 1 protein", "gene_name": "SLIT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALTPGWGSSAGPVRPELWLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA", "length": 1534 }, "evidence": [ { "id": "E1BP10", "url": "https://omabrowser.org/oma/group/E1BP10/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O88279-1", "protein_name": "Slit homolog 1 protein", "gene_name": "Slit1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALTPQRGSSSGLSRPELWLLLWAAAWRLGATACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENSLQAVPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAAQVPACTLSSGSCPAMCSCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETTGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYHLNSECTSDVACPHKCRCEASVVECSGLKLSKIPERIPQSTTELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGATSVSELHLTANQLESVRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPFNCNCQLAWLGDWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEVGCLPRPQCPQECACLDTVVRCSNKHLQALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDVSTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPPEMEGKLLLTTPAKKFECQGPPSLAVQAKCDPCLSSPCQNQGTCHNDPLEVYRCTCPSGYKGRNCEVSLDSCSSNPCGNGGTCHAQEGEDAGFTCSCPSGFEGLTCGMNTDDCVKHDCVNGGVCVDGIGNYTCQCPLQYTGRACEQLVDFCSPDLNPCQHEAQCVGTPEGPRCECVPGYTGDNCSKNQDDCKDHQCQNGAQCVDEINSYACLCAEGYSGQLCEIPPAPRNSCEGTECQNGANCVDQGSRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTSFHGCIRNLYINNELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPVDGPCHGHKCVHGKCVPLDALAYSCQCQDGYSGALCNQVGAVAEPCGGLQCLHGHCQASATRGAHCVCSPGFSGELCEQESECRGDPVRDFHRVQRGYAICQTTRPLSWVECRGACPGQGCCQGLRLKRRKLTFECSDGTSFAEEVEKPTKCGCAPCA", "length": 1531 }, "evidence": [ { "id": "E1BP10", "url": "https://omabrowser.org/oma/group/E1BP10/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P24014-1", "protein_name": "Protein slit", "gene_name": "sli", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAAPSRTTLMPPPFRLQLRLLILPILLLLRHDAVHAEPYSGGFGSSAVSSGGLGSVGIHIPGGGVGVITEARCPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIHTIERNSFQDLVSLERLRLNNNRLKAIPENFVTSSASLLRLDISNNVITTVGRRVFKGAQSLRSLQLDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSWLSRFLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSGLTEHAPMECGAENSCPHPCRCADGIVDCREKSLTSVPVTLPDDTTELRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDLPSGVFKGLGSLQLLLLNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKSIKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARCESPKRMHRRRIESLREEKFKCSWDELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRGLKEIPRDIPLHTTELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSLTSLNLASNPFNCNCHLAWFAEWLRKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSEGCLGDGYCPPSCTCTGTVVRCSRNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYNKLQCLQRHALSGLNNLRVLSLHGNRISMLPEGSFEDLKSLTHIALGSNPLYCDCGLKWFSDWIKLDYVEPGIARCAEPEQMKDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQAQCVALPQREYQCLCQPGYHGKHCEFMIDACYGNPCRNNATCTVLEEGRFSCQCAPGYTGARCETNIDDCLGEIKCQNNATCIDGVESYKCECQPGFSGEFCDTKIQFCSPEFNPCANGAKCMDHFTHYSCDCQAGFHGTNCTDNIDDCQNHMCQNGGTCVDGINDYQCRCPDDYTGKYCEGHNMISMMYPQTSPCQNHECKHGVCFQPNAQGSDYLCRCHPGYTGKWCEYLTSISFVHNNSFVELEPLRTRPEANVTIVFSSAEQNGILMYDGQDAHLAVELFNGRIRVSYDVGNHPVSTMYSFEMVADGKYHAVELLAIKKNFTLRVDRGLARSIINEGSNDYLKLTTPMFLGGLPVDPAQQAYKNWQIRNLTSFKGCMKEVWINHKLVDFGNAQRQQKITPGCALLEGEQQEEEDDEQDFMDETPHIKEEPVDPCLENKCRRGSRCVPNSNARDGYQCKCKHGQRGRYCDQGEGSTEPPTVTAASTCRKEQVREYYTENDCRSRQPLKYAKCVGGCGNQCCAAKIVRRRKVRMVCSNNRKYIKNLDIVRKCGCTKKCY", "length": 1504 }, "evidence": [ { "id": "E1BP10", "url": "https://omabrowser.org/oma/group/E1BP10/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q80TR4-1", "protein_name": "Slit homolog 1 protein", "gene_name": "Slit1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALTPQRGSSSGLSRPELWLLLWAAAWRLGATACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENFLQAVPRKAFRGATDLKNLQLDKNRISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKGEFSCSGQGEAAGAPACTLSSGSCPAMCSCSSGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETTGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYHLNSECTSDVACPHKCRCEASVVECSSLKLSKIPERIPQSTTELRLNNNEISILEATGLFKKLSHLKKINLSNNKVSEIEDGTFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLANPFNCNCHLSWLGDWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEVGCLPRPQCPQECACLDTVVRCSNKHLQALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDVSTLQEGIFADVTSLSHLAIGANPLYCDCRLRWLSSWVKTGYKEPGIARCAGPPEMEGKLLLTTPAKKFECQGPPSLAVQAKCDPCLSSPCQNQGTCHNDPLEVYRCTCPSGYKGRHCEVSLDGCSSNPCGNGGTCHAQEGEDAGFTCSCPSGFEGPTCGVDTDDCVKHACVNGGVCVDGVGNYTCQCPLQYTGRACEQLVDFCSPDMNPCQHEAQCVGTPDGPRCECMLGYTGDNCSENQDDCKDHKCQNGAQCVDEVNSYACLCVEGYSGQLCEIPPAPRSSCEGTECQNGANCVDQGSRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTSFHGCIRNLYINNELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPVCHCEAGWGGLHCDQPVDGPCHGHKCVHGKCVPLDALAYSCQCQDGYSGALCNQVGAVAEPCGGLQCLHGHCQASATKGAHCVCSPGFSGELCEQESECRGDPVRDFHRVQRGYAICQTTRPLSWVECRGACPGQGCCQGLRLKRRKLTFECSDGTSFAEEVEKPTKCGCAQCA", "length": 1531 }, "evidence": [ { "id": "E1BP10", "url": "https://omabrowser.org/oma/group/E1BP10/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "E1BP10", "url": "https://www.uniprot.org/uniprotkb/E1BP10" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "E1BP10", "url": "https://www.uniprot.org/uniprotkb/E1BP10" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BP10", "url": "https://www.uniprot.org/uniprotkb/E1BP10" } ], "pmid": "" }, { "name": "Roundabout binding", "id": "GO:0048495", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048495", "evidence": [ { "database": "UniProtKB", "id": "E1BP10", "url": "https://www.uniprot.org/uniprotkb/E1BP10" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative chemotaxis", "id": "GO:0050919", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050919", "evidence": [ { "database": "UniProtKB", "id": "E1BP10", "url": "https://www.uniprot.org/uniprotkb/E1BP10" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "E1BP10", "url": "https://www.uniprot.org/uniprotkb/E1BP10" } ], "pmid": "" }, { "name": "motor neuron axon guidance", "id": "GO:0008045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008045", "evidence": [ { "database": "UniProtKB", "id": "E1BP10", "url": "https://www.uniprot.org/uniprotkb/E1BP10" } ], "pmid": "" }, { "name": "axon extension involved in axon guidance", "id": "GO:0048846", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048846", "evidence": [ { "database": "UniProtKB", "id": "E1BP10", "url": "https://www.uniprot.org/uniprotkb/E1BP10" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1079, "end_pos": 1081, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1189, "end_pos": 1191, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1259, "end_pos": 1261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1306, "end_pos": 1308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1355, "end_pos": 1357, "annotation": "n_glycosylation_sequon" }, { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" }, { "start_pos": 571, "end_pos": 573, "annotation": "n_glycosylation_sequon" }, { "start_pos": 630, "end_pos": 632, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" }, { "start_pos": 762, "end_pos": 764, "annotation": "n_glycosylation_sequon" }, { "start_pos": 801, "end_pos": 803, "annotation": "n_glycosylation_sequon" }, { "start_pos": 806, "end_pos": 808, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BP10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP10" }, { "id": "PS01225", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01225" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CTCK", "eco_id": "ECO_0000259", "start_pos": 1459, "end_pos": 1534, "start_aa": "Cys", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BP10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP10" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 927, "end_pos": 962, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BP10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP10" }, { "id": "PS50025", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50025" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Laminin G", "eco_id": "ECO_0000259", "start_pos": 1166, "end_pos": 1339, "start_aa": "Leu", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA 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"site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BP41-1", "uniprot_ac": "E1BP41", "uniprot_id": "E1BP41_BOVIN", "mass": { "chemical_mass": 55166.0, "monoisotopic_mass": 55166.0 }, "refseq": { "ac": "XP_005206297", "name": "cysteine sulfinic acid decarboxylase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206297" }, "gene_names": [ { "name": "CSAD", "type": "recommended", "evidence": [ { "id": "E1BP41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP41" } ] }, { "name": "CSAD", "type": "synonym", "evidence": [ { "id": "XP_005206297", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206297" } ] } ], "protein_names": [ { "name": "Cysteine sulfinic acid decarboxylase", "type": "synonym", "evidence": [ { "id": "E1BP41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP41/entry#names_and_taxonomy" } ] }, { "name": "cysteine sulfinic acid decarboxylase isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005206297", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206297" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP41", "url": "https://www.uniprot.org/uniprotkb/E1BP41" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CSAD", "url": "https://www.uniprot.org/uniprotkb/E1BP41", "locus": { "chromosome": "5", "start_pos": 26848932, "end_pos": 26821026, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007829", "url": "https://www.ensembl.org/id/ENSBTAG00000007829" } ] } } ], "crossref": [ { "id": "E1BP41", "url": "https://alphafold.ebi.ac.uk/entry/E1BP41", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007829", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007829", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06450", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06450", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "516241", "url": "https://www.ncbi.nlm.nih.gov/gene/516241", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015424", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015424", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:516241", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516241", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CVDLHKW", "url": "https://omabrowser.org/oma/group/CVDLHKW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BP41", "url": "https://www.orthodb.org/?gene=E1BP41", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45677", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45677", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45677:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45677:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00282", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00282", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005206297", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206297", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T8U5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8U5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8U5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8U5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP41", "url": "https://www.uniprot.org/uniprotkb/E1BP41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP41-1", "url": "https://www.uniprot.org/uniprotkb/E1BP41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP42", "url": "https://www.uniprot.org/uniprotkb/E1BP42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP42-1", "url": "https://www.uniprot.org/uniprotkb/E1BP42-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADSQPLLSLDGDPVAAEALLQDVFGIVVDEVIRKGTSASEKVCEWKEPEELKQLLDLELRHEGESQEQILEHCRAVIRYSVKTCHPRFFNQLFSGLDPHALAGRIVTESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWSSGDGVFCPGGSISNMYAVNLARYQRYPDCKQRGLRALPPLALFTSKECHYSIKKGAAFLGLGTDSVRVVKADERGKMIPEDLERQISLAKAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQHHGLWLHVDAAWGGSVLLSQTHRHLLAGIQRADSVAWNPHKLLSTGLQCSALLLRDTSNLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGEQGLQRRVDQAFALARYLVEELKKREGFELVMEPEFVNVCFWFVPPSLRGKKGSPDYSERLSKVAPILKERMVRKGSMMIGYQPHGTRSNFFRMVVANPALTRADMDFLLNELERLGQDL", "length": 493, "header": "tr|E1BP41-1|E1BP41_BOVIN Isoform 1 of Cysteine sulfinic acid decarboxylase OS=Bos taurus OX=9913 GN=CSAD PE=3 SV=2 CANONICAL=E1BP41-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T8U5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8U5/entry", "sequence": { "sequence": "SQLCPLPPVYLDRDQSRKILMADSQPLLSLDGDPVAAEALLQDVFGIVVDEVIRKGTSASEKVCEWKEPEELKQLLDLELRHEGESQEQILEHCRAVIRYSVKTCHPRFFNQLFSGLDPHALAGRIVTESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWSSGDGVFCPGGSISNMYAVNLARYQRYPDCKQRGLRALPPLALFTSKECHYSIKKGAAFLGLGTDSVRVVKADERGKMIPEDLERQISLAKAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQHHGLWLHVDAAWGGSVLLSQTHRHLLAGIQRADSVAWNPHKLLSTGLQCSALLLRDTSNLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGEQGLQRRVDQAFALARYLVEELKKREGFELVMEPEFVNVCFWFVPPSLRGKKGSPDYSERLSKVAPILKERMVRKGSMMIGYQPHGTRSNFFRMVVANPALTRADMDFLLNELERLGQDL", "length": 513, "header": "tr|A0AAA9T8U5-1|E1BP41_BOVIN Computationally mapped isoform of Cysteine sulfinic acid decarboxylase OS=Bos taurus OX=9913 GN=CSAD PE=3 SV=1 CANONICAL=E1BP41-1" }, "locus": { "chromosome": "5", "start_pos": 26847928, "end_pos": 26837199, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093353.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093353.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093258.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093258.1" } ] } }, { "isoform_ac": "E1BP41-1", "url": "https://www.uniprot.org/uniprotkb/E1BP41/entry", "sequence": { "sequence": "MADSQPLLSLDGDPVAAEALLQDVFGIVVDEVIRKGTSASEKVCEWKEPEELKQLLDLELRHEGESQEQILEHCRAVIRYSVKTCHPRFFNQLFSGLDPHALAGRIVTESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWSSGDGVFCPGGSISNMYAVNLARYQRYPDCKQRGLRALPPLALFTSKECHYSIKKGAAFLGLGTDSVRVVKADERGKMIPEDLERQISLAKAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQHHGLWLHVDAAWGGSVLLSQTHRHLLAGIQRADSVAWNPHKLLSTGLQCSALLLRDTSNLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGEQGLQRRVDQAFALARYLVEELKKREGFELVMEPEFVNVCFWFVPPSLRGKKGSPDYSERLSKVAPILKERMVRKGSMMIGYQPHGTRSNFFRMVVANPALTRADMDFLLNELERLGQDL", "length": 493, "header": "tr|E1BP41-1|E1BP41_BOVIN Isoform 1 of Cysteine sulfinic acid decarboxylase OS=Bos taurus OX=9913 GN=CSAD PE=3 SV=2 CANONICAL=E1BP41-1" }, "locus": { "chromosome": "5", "start_pos": 26847928, "end_pos": 26837503, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010305.8", "url": "https://www.ensembl.org/id/ENSBTAT00000010305.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010305.5", "url": "https://www.ensembl.org/id/ENSBTAP00000010305.5" } ] } }, { "isoform_ac": "E1BP42-1", "url": "https://www.uniprot.org/uniprotkb/E1BP42/entry", "sequence": { "sequence": "MADSQPLLSLDGDPVAAEALLQDVFGIVVDEVIRKGTSASEKCHYSIKKGAAFLGLGTDSVRVVKADERGKMIPEDLERQISLAKAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQHHGLWLHVDAAWGGSVLLSQTHRHLLAGIQRADSVAWNPHKLLSTGLQCSALLLRDTSNLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGEQGLQRRVDQAFALARYLVEELKKREGFELVMEPEFVNVCFWFVPPSLRGKKGSPDYSERLSKVAPILKERMVRKGSMMIGYQPHGTRSNFFRMVVANPALTRADMDFLLNELERLGQDL", "length": 346, "header": "tr|E1BP42-1|E1BP41_BOVIN Computationally mapped isoform of Cysteine sulfinic acid decarboxylase OS=Bos taurus OX=9913 GN=CSAD PE=3 SV=4 CANONICAL=E1BP41-1" }, "locus": { "chromosome": "5", "start_pos": 26847928, "end_pos": 26837503, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010303.8", "url": "https://www.ensembl.org/id/ENSBTAT00000010303.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010303.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010303.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:516241", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516241", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q64611-1", "protein_name": "Cysteine sulfinic acid decarboxylase", "gene_name": "Csad", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADSKPLRTLDGDPVAVEALLRDVFGIVVDEAIRKGTNASEKVCEWKEPEELKQLLDLELQSQGESRERILERCRAVIHYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWNTGDGVFCPGGSISNMYAINLARFQRYPDCKQRGLRALPPLALFTSKECHYSITKGAAFLGLGTDSVRVVKADERGKMIPEDLERQISLAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRHGLWLHVDAAWGGSVLLSRTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLRDTSNLLKRCHGSQASYLFQQDKFYNVALDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLEWRIDQAFALTRYLVEEIKKREGFELVMEPEFVNVCFWFVPPSLRGKKESPDYSQRLSQVAPVLKERMVKKGTMMIGYQPHGTRANFFRMVVANPILVQADIDFLLGELERLGQDL", "length": 493 }, "evidence": [ { "id": "E1BP41", "url": "https://omabrowser.org/oma/group/E1BP41/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DBE0-1", "protein_name": "Cysteine sulfinic acid decarboxylase", "gene_name": "Csad", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADSKPLRTLDGDPVAVEALLQDVFGIVVDEAILKGTSASEKVCEWKEPEELKQLLDLELQSQGESREQILERCRTVIHYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGWNSGDGVFCPGGSISNMYAMNLARFQRYPDCKQRGLRALPPLALFTSKECHYSITKGAAFLGLGTDSVRVVKADERGRMIPEDLERQIILAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRHGLWFHVDAAWGGSVLLSRTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLRDTSNLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLERRIDQAFALTRYLVEEIKKREGFELVMEPEFVNVCFWFVPPSLRGKKESPDYSQRLSQVAPVLKERMVKKGTMMIGYQPHGTRANFFRMVVANPILAQADIDFLLGELELLGQDL", "length": 493 }, "evidence": [ { "id": "E1BP41", "url": "https://omabrowser.org/oma/group/E1BP41/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y600-1", "protein_name": "Cysteine sulfinic acid decarboxylase", "gene_name": "CSAD", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADSEALPSLAGDPVAVEALLRAVFGVVVDEAIQKGTSVSQKVCEWKEPEELKQLLDLELRSQGESQKQILERCRAVIRYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVGWSSGDGIFCPGGSISNMYAVNLARYQRYPDCKQRGLRTLPPLALFTSKECHYSIQKGAAFLGLGTDSVRVVKADERGKMVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDTSNLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCFWFVPPSLRGKQESPDYHERLSKVAPVLKERMVKEGSMMIGYQPHGTRGNFFRVVVANSALTCADMDFLLNELERLGQDL", "length": 493 }, "evidence": [ { "id": "E1BP41", "url": "https://omabrowser.org/oma/group/E1BP41/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "E1BP41", "url": "https://www.uniprot.org/uniprotkb/E1BP41" } ], "pmid": "" }, { "name": "carboxy-lyase activity", "id": "GO:0016831", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016831", "evidence": [ { "database": "UniProtKB", "id": "E1BP41", "url": "https://www.uniprot.org/uniprotkb/E1BP41" } ], "pmid": "" }, { "name": "sulfinoalanine decarboxylase activity", "id": "GO:0004782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004782", "evidence": [ { "database": "UniProtKB", "id": "E1BP41", "url": "https://www.uniprot.org/uniprotkb/E1BP41" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "carboxylic acid metabolic process", "id": "GO:0019752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019752", "evidence": [ { "database": "UniProtKB", "id": "E1BP41", "url": "https://www.uniprot.org/uniprotkb/E1BP41" } ], "pmid": "" }, { "name": "taurine biosynthetic process", "id": "GO:0042412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042412", "evidence": [ { "database": "UniProtKB", "id": "E1BP41", "url": "https://www.uniprot.org/uniprotkb/E1BP41" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BP41", "url": "https://www.uniprot.org/uniprotkb/E1BP41" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BP41-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 493, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BP41-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BP41" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 112, "end_pos": 114 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BP06-1", "uniprot_ac": "E1BP06", "uniprot_id": "E1BP06_BOVIN", "mass": { "chemical_mass": 41417.0, "monoisotopic_mass": 41417.0 }, "refseq": { "ac": "XP_005202603", "name": "5-hydroxytryptamine receptor 5B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202603" }, "gene_names": [ { "name": "LOC523484", "type": "recommended", "evidence": [ { "id": "E1BP06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP06" } ] }, { "name": "LOC523484", "type": "synonym", "evidence": [ { "id": "XP_005202603", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202603" } ] } ], "protein_names": [ { "name": "G-protein coupled receptors family 1 profile domain-containing protein", "type": "recommended", "evidence": [ { "id": "E1BP06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP06/entry#names_and_taxonomy" } ] }, { "name": "5-hydroxytryptamine receptor 5B", "type": "synonym", "evidence": [ { "id": "XP_005202603", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202603" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP06", "url": "https://www.uniprot.org/uniprotkb/E1BP06" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC523484", "url": "https://www.uniprot.org/uniprotkb/E1BP06", "locus": {} } ], "crossref": [ { "id": "E1BP06", "url": "https://alphafold.ebi.ac.uk/entry/E1BP06", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016785", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016785", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523484", "url": "https://www.ncbi.nlm.nih.gov/gene/523484", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000431", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000431", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523484", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523484", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LFGWGEV", "url": "https://omabrowser.org/oma/group/LFGWGEV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BP06", "url": "https://www.orthodb.org/?gene=E1BP06", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24248", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24248", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24248:SF202", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24248:SF202", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005202603", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202603", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TL96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TL96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP06", "url": "https://www.uniprot.org/uniprotkb/E1BP06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP06-1", "url": "https://www.uniprot.org/uniprotkb/E1BP06-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRAMEAANLSVASTGVALRLGPEAFSSSPNPSGVIGSTPGGAAPPGREPPFSVFSVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSAGRRWLLGRSLCHVWISFDVMCCTASIWNVAAIALDRYWTITRHLQYTLRTRRRASMLMIALTWALSALIALAPLLFGWGEAYDARLQRCQVSQEPSYAVFSTCGAFYLPLGVVLFVYWKIYKAAKFRFGRRCRAVLPLPSTVQVKEDPQEAEMVFTARRPTVAFQTSGASWREQKEKRAAVMVGILIGVFVLCWIPFFLAELIGPLCACSLPPIWKSVFLWLGYSNSFFNPLIYTAFNKNYNNAFKNLFTKQR", "length": 373, "header": "tr|E1BP06-1|E1BP06_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC523484 PE=3 SV=2 CANONICAL=E1BP06-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TL96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TL96/entry", "sequence": { "sequence": "MPRAMEAANLSVASTGVALRLGPEAFSSSPNPSGVIGSTPGGAAPPGREPPFSVFSVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSAGRRWLLGRSLCHVWISFDVMCCTASIWNVAAIALDRYWTITRHLQYTLRTRRRASMLMIALTWALSALIALAPLLFGWGEAYDARLQRCQVSQEPSYAVFSTCGAFYLPLGVVLFVYWKIYKAAKFRFGRRCRAVLPLPSTVQVFIAARGLSLVVASGSYSLVAVCGLTEVAFLVVDHRLLGTQASVVVTCRLQSLGSATVTHRLSCPAACRIFLDQGLNLCPLL", "length": 345, "header": "tr|A0AAA9TL96-1|E1BP06_BOVIN Computationally mapped isoform of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC523484 PE=3 SV=1 CANONICAL=E1BP06-1" }, "locus": { "chromosome": "2", "start_pos": 69542700, "end_pos": 69535964, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113476.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113476.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097968.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097968.1" } ] } }, { "isoform_ac": "E1BP06-1", "url": "https://www.uniprot.org/uniprotkb/E1BP06/entry", "sequence": { "sequence": "MPRAMEAANLSVASTGVALRLGPEAFSSSPNPSGVIGSTPGGAAPPGREPPFSVFSVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSAGRRWLLGRSLCHVWISFDVMCCTASIWNVAAIALDRYWTITRHLQYTLRTRRRASMLMIALTWALSALIALAPLLFGWGEAYDARLQRCQVSQEPSYAVFSTCGAFYLPLGVVLFVYWKIYKAAKFRFGRRCRAVLPLPSTVQVKEDPQEAEMVFTARRPTVAFQTSGASWREQKEKRAAVMVGILIGVFVLCWIPFFLAELIGPLCACSLPPIWKSVFLWLGYSNSFFNPLIYTAFNKNYNNAFKNLFTKQR", "length": 373, "header": "tr|E1BP06-1|E1BP06_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC523484 PE=3 SV=2 CANONICAL=E1BP06-1" }, "locus": { "chromosome": "2", "start_pos": 69553831, "end_pos": 69535964, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022318.5", "url": "https://www.ensembl.org/id/ENSBTAT00000022318.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022318.4", "url": "https://www.ensembl.org/id/ENSBTAP00000022318.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 39, "start_aa": "Thr", "end_pos": 39, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr39", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:523484", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523484", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LZE3-1", "protein_name": "5-hydroxytryptamine receptor 5B", "gene_name": "LOC100759887", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEVSSLSSATPGMAFSSEPESCSDSPSSNRGVGSTPGGFLLPGREPHFSIFTVLVVTLLVLLIAATFLWNLLVLVTILRVRTFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSAGRRWQLGRSLCHVWISFDVLCCTASIWNVAAIALDRYWTITRHLQYTLRTRRRASALMIGVTWALSALIALAPLLFGWGEAYDARLQRCQVSQEPSYAVFSTCGAFYLPLAVVLFVYWKIYKAAKFRFGRRRRAVVPLSATTQAKEVPEEAEMVFTARCRATVTFQTSGDSWREQKEKRAAMMVGILIGVFVLCWIPFFLAELISPLCACSLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSLFTKQR", "length": 370 }, "evidence": [ { "id": "E1BP06", "url": "https://omabrowser.org/oma/group/E1BP06/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P31387-1", "protein_name": "5-hydroxytryptamine receptor 5B", "gene_name": "Htr5b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVSNLSGATPGLAFPPGPESCSDSPSSGRSMGSTPGGLILPGREPPFSAFTVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAVLVMPLSLVSELSAGRRWQLGRSLCHVWISFDVLCCTASIWNVAAIALDRYWTITRHLQYTLRTRSRASALMIAITWALSALIALAPLLFGWGEAYDARLQRCQVSQEPSYAVFSTCGAFYLPLAVVLFVYWKIYKAAKFRFGRRRRAVVPLPATTQAKEAPPESEMVFTARRRATVTFQTSGDSWREQKEKRAAMMVGILIGVFVLCWIPFFLTELISPLCACSLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSLFTKQR", "length": 370 }, "evidence": [ { "id": "E1BP06", "url": "https://omabrowser.org/oma/group/E1BP06/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P35365-1", "protein_name": "5-hydroxytryptamine receptor 5B", "gene_name": "Htr5b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVSNLSGATPGIAFPPGPESCSDSPSSGRSMGSTPGGLILSGREPPFSAFTVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSAGRRWQLGRSLCHVWISFDVLCCTASIWNVAAIALDRYWTITRHLQYTLRTRRRASALMIAITWALSALIALAPLLFGWGEAYDARLQRCQVSQEPSYAVFSTCGAFYVPLAVVLFVYWKIYKAAKFRFGRRRRAVVPLPATTQAKEAPQESETVFTARCRATVAFQTSGDSWREQKEKRAAMMVGILIGVFVLCWIPFFLTELVSPLCACSLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSLFTKQR", "length": 370 }, "evidence": [ { "id": "E1BP06", "url": "https://omabrowser.org/oma/group/E1BP06/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BP06", "url": "https://www.uniprot.org/uniprotkb/E1BP06" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "E1BP06", "url": "https://www.uniprot.org/uniprotkb/E1BP06" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "E1BP06", "url": "https://www.uniprot.org/uniprotkb/E1BP06" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled serotonin receptor activity", "id": "GO:0004993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004993", "evidence": [ { "database": "UniProtKB", "id": "E1BP06", "url": "https://www.uniprot.org/uniprotkb/E1BP06" } ], "pmid": "" }, { "name": "neurotransmitter receptor activity", "id": "GO:0030594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030594", "evidence": [ { "database": "UniProtKB", "id": "E1BP06", "url": "https://www.uniprot.org/uniprotkb/E1BP06" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger", "id": "GO:0007187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007187", "evidence": [ { "database": "UniProtKB", "id": "E1BP06", "url": "https://www.uniprot.org/uniprotkb/E1BP06" } ], "pmid": "" }, { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "E1BP06", "url": "https://www.uniprot.org/uniprotkb/E1BP06" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BP06-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 373, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BP06-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BP06" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BP06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP06" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 73, "end_pos": 354, "start_aa": "Trp", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 39 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BP12-1", "uniprot_ac": "E1BP12", "uniprot_id": "E1BP12_BOVIN", "mass": { "chemical_mass": 40487.0, "monoisotopic_mass": 40487.0 }, "refseq": { "ac": "NP_001421916", "name": "tubulinyl-Tyr carboxypeptidase 2 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421916" }, "gene_names": [ { "name": "VASH2", "type": "recommended", "evidence": [ { "id": "E1BP12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP12" } ] }, { "name": "VASH2", "type": "synonym", "evidence": [ { "id": "NP_001421916", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421916" } ] } ], "protein_names": [ { "name": "Vasohibin 2", "type": "synonym", "evidence": [ { "id": "E1BP12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP12/entry#names_and_taxonomy" } ] }, { "name": "tubulinyl-Tyr carboxypeptidase 2 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001421916", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421916" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP12", "url": "https://www.uniprot.org/uniprotkb/E1BP12" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VASH2", "url": "https://www.uniprot.org/uniprotkb/E1BP12", "locus": { "chromosome": "16", "start_pos": 70600756, "end_pos": 70639694, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003701", "url": "https://www.ensembl.org/id/ENSBTAG00000003701" } ] } } ], "crossref": [ { "id": "E1BP12", "url": "https://alphafold.ebi.ac.uk/entry/E1BP12", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003701", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003701", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539085", "url": "https://www.ncbi.nlm.nih.gov/gene/539085", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028131", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028131", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WERMWAH", "url": "https://omabrowser.org/oma/group/WERMWAH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BP12", "url": "https://www.orthodb.org/?gene=E1BP12", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6PTR8", "url": "https://www.orthodb.org/?gene=F6PTR8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15750", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15750", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15750:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15750:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14822", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14822", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001421916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421916", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BP12", "url": "https://www.uniprot.org/uniprotkb/E1BP12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP12-1", "url": "https://www.uniprot.org/uniprotkb/E1BP12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PTR8", "url": "https://www.uniprot.org/uniprotkb/F6PTR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6PTR8-1", "url": "https://www.uniprot.org/uniprotkb/F6PTR8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTGSAADTHRRPHPKGAKGTRSRSSHARPVSLATSGGSEEEDKDGGVLFHVNKSGFPIDSHTWERMWLHVAKVHPKGGEMVGAIRNATFLAKPSIPQVPNYRLSMTIPDWLQAIQNYMKTLQYNHTGTQFFEIRKMRPLSGLMETAKEMTRESLPIKCLEAVILGIYLTNGQPSIERFPISFKTYFSGNYFHHVVLGIYCNGRYGSLGMSRRAELMDKPLTFRTLSDLIFDFEDSYKKYLHTVKKVKIGLYVPHEPHSFQPIEWKQLVLNVSKMLRADIRKELEKYARDMRMKILKPASAHSPTQVRSRGKSLSPRRRQASPPRRLGRRDKSPALPEKKVADVSTLNEVGYQIRI", "length": 355, "header": "tr|E1BP12-1|E1BP12_BOVIN Isoform 1 of Vasohibin 2 OS=Bos taurus OX=9913 GN=VASH2 PE=4 SV=4 CANONICAL=E1BP12-1" }, "isoforms": [ { "isoform_ac": "E1BP12-1", "url": "https://www.uniprot.org/uniprotkb/E1BP12/entry", "sequence": { "sequence": "MTGSAADTHRRPHPKGAKGTRSRSSHARPVSLATSGGSEEEDKDGGVLFHVNKSGFPIDSHTWERMWLHVAKVHPKGGEMVGAIRNATFLAKPSIPQVPNYRLSMTIPDWLQAIQNYMKTLQYNHTGTQFFEIRKMRPLSGLMETAKEMTRESLPIKCLEAVILGIYLTNGQPSIERFPISFKTYFSGNYFHHVVLGIYCNGRYGSLGMSRRAELMDKPLTFRTLSDLIFDFEDSYKKYLHTVKKVKIGLYVPHEPHSFQPIEWKQLVLNVSKMLRADIRKELEKYARDMRMKILKPASAHSPTQVRSRGKSLSPRRRQASPPRRLGRRDKSPALPEKKVADVSTLNEVGYQIRI", "length": 355, "header": "tr|E1BP12-1|E1BP12_BOVIN Isoform 1 of Vasohibin 2 OS=Bos taurus OX=9913 GN=VASH2 PE=4 SV=4 CANONICAL=E1BP12-1" }, "locus": { "chromosome": "16", "start_pos": 70638694, "end_pos": 70601760, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061152.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061152.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053485.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053485.4" } ] } }, { "isoform_ac": "F6PTR8-1", "url": "https://www.uniprot.org/uniprotkb/F6PTR8/entry", "sequence": { "sequence": "MTGSAADTHRRPHPKGAKGTRSRSSHARPVSLATSGGSEEEDKDGGVLFHVNKSGFPIDSHTWERMWLHVAKVHPKGGEMVGAIRNATFLAKPSIPQVPNYRLSMTIPDWLQAIQNYMKTLQYLTNGQPSIERFPISFKTYFSGNYFHHVVLGIYCNGRYGSLGMSRRAELMDKPLTFRTLSDLIFDFEDSYKKYLHTVKKVKIGLYVPHEPHSFQPIEWKQLVLNVSKMLRADIRKELEKYARDMRMKILKPASAHSPTQVRSRGKSLSPRRRQASPPRRLGRRDKSPALPEKKVADVSTLNEVGYQIRI", "length": 311, "header": "tr|F6PTR8-1|E1BP12_BOVIN Computationally mapped isoform of Vasohibin 2 OS=Bos taurus OX=9913 GN=VASH2 PE=4 SV=2 CANONICAL=E1BP12-1" }, "locus": { "chromosome": "16", "start_pos": 70638694, "end_pos": 70601760, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000004821.4", "url": "https://www.ensembl.org/id/ENSBTAT00000004821.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000004821.4", "url": "https://www.ensembl.org/id/ENSBTAP00000004821.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8M2B7N9-1", "protein_name": "Tubulinyl-Tyr carboxypeptidase 2 isoform X1", "gene_name": "vash2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTGPSATSSGSAAKISRHGRSKSTSAYCHSTGPAAESSPSTAANNTGRSSGEEEEKDGGVPFFVNRTGFPIESVTWERMWSHVAKVHPDGQEMVDRIRNATLLPKHSVPSVPNFKPSMSVPDWLHAVQNYMRNLQYNHTGTQFFEIKKTRPLSGLMETAREMIRESLPIKCLEAVILGIYLTNGLTSVERFPISFKTQFSGHHFHHVVLGVYCNGRYGTLGMSRRTDLMDRSLSFRTLSELVFDFEDSYRRYQHTMKKIKIGLYVPHNPHVFQPIEWNYLVINASKQAREDMRKELEKHGRDMRMKILKSSSAQSPIKERTRGKSLSPRRRPGSSPQRRQHAHRRDKSPAALDRKPAELSTLSDGYQIRI", "length": 370 }, "evidence": [ { "id": "E1BP12", "url": "https://omabrowser.org/oma/group/E1BP12/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0ABK0M8G3-1", "protein_name": "Vasohibin 2", "gene_name": "Vash2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTGSAADTHRCPHPKSIKGTRSRSSHARPVSLATSGGSEEEDKDGGVLFHVNKSGFPIDSHTWERMWLHVAKVHPRGGEMVGAIRNAAFLAKPSIPQVPNYRLSMTIPDWLQAIQNYMKTLQYNHTGTQFFEIRKMRPLSGLMETAKEMTRESLPIKCLEAVILGIYLTNGQPSIERFPISFKTYFSGSYFHHVVLGIYCNGYYGSLGMSRRAELMDKPLTFRTLSDLVFDFEDSYKKYLHTVKKVKIGLYVPHEPHSFQPIEWKQLVLNVSKMLRADIRKELEKYARDMRMKILKPASGHSPTQVRIRGKSLSPRRRQASPPRRLGRRDKSPALTEKKVADLSTLNEVGYQIRI", "length": 355 }, "evidence": [ { "id": "E1BP12", "url": "https://omabrowser.org/oma/group/E1BP12/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S2X7-1", "protein_name": "Vasohibin 2", "gene_name": "VASH2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTGSAADTHRCPHPKGAKGTRSRSSHARPVSLATSGGSEEEDKDGGVLFHVNKSGFPIDSHTWERMWMHVAKVHPKGGEMVGAIRNATFLAKPSIPQVPNYRLSMTVPDWLQAIQNYMKTLQYNHTGTQFFEIRKMRPLSGLMETAKEMTRESLPIKCLEAVILGIYFTNGQPSIERFPISFKTYFSGNYFHHVVLGIYCNGRYGSLGMSRRAELMDKPLTFRTLSDLIFDFEDSYKKYLHTLKKVKIGLYVPHEPHSFQPIEWKQLVLNVSKMLRADVRKELEKYARDMRMKILKPASAHSPTQVRSRGKSLSPRRRQASPPRRLGRRDKSPALPEKKVADLSTLNEVGYQIRI", "length": 355 }, "evidence": [ { "id": "E1BP12", "url": "https://omabrowser.org/oma/group/E1BP12/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q86V25-1", "protein_name": "Tubulinyl-Tyr carboxypeptidase 2", "gene_name": "VASH2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTGSAADTHRCPHPKGAKGTRSRSSHARPVSLATSGGSEEEDKDGGVLFHVNKSGFPIDSHTWERMWMHVAKVHPKGGEMVGAIRNAAFLAKPSIPQVPNYRLSMTIPDWLQAIQNYMKTLQYNHTGTQFFEIRKMRPLSGLMETAKEMTRESLPIKCLEAVILGIYLTNGQPSIERFPISFKTYFSGNYFHHVVLGIYCNGRYGSLGMSRRAELMDKPLTFRTLSDLIFDFEDSYKKYLHTVKKVKIGLYVPHEPHSFQPIEWKQLVLNVSKMLRADIRKELEKYARDMRMKILKPASAHSPTQVRSRGKSLSPRRRQASPPRRLGRREKSPALPEKKVADLSTLNEVGYQIRI", "length": 355 }, "evidence": [ { "id": "E1BP12", "url": "https://omabrowser.org/oma/group/E1BP12/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C5G2-1", "protein_name": "Tubulinyl-Tyr carboxypeptidase 2", "gene_name": "Vash2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTGSAADTHRCPHPKITKGTRSRSSHARPVSLATSGGSEEEDKDGGVLFHVNKSGFPIDSHTWERMWLHVAKVHPRGGEMVGAIRNAAFLAKPSIPQVPNYRLSMTIPDWLQAIQNYMKTLQYNHTGTQFFEIRKMRPLSGLMETAKEMTRESLPIKCLEAVILGIYLTNGQPSIERFPISFKTYFSGNYFHHVVLGIYCNGYYGSLGMSRRAELMDKPLTFRTLSDLVFDFEDSYKKYLHTVKKVKIGLYVPHEPHSFQPIEWKQLVLNVSKMLRADIRKELEKYARDMRMKILKPASAHSPTQVRSRGKSLSPRRRQASPPRRLGRRDKSPALTEKKVADLGTLNEVGYQIRI", "length": 355 }, "evidence": [ { "id": "E1BP12", "url": "https://omabrowser.org/oma/group/E1BP12/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "E1BP12", "url": "https://www.uniprot.org/uniprotkb/E1BP12" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "E1BP12", "url": "https://www.uniprot.org/uniprotkb/E1BP12" } ], "pmid": "" }, { "name": "metallocarboxypeptidase activity", "id": "GO:0004181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004181", "evidence": [ { "database": "UniProtKB", "id": "E1BP12", "url": "https://www.uniprot.org/uniprotkb/E1BP12" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BP12", "url": "https://www.uniprot.org/uniprotkb/E1BP12" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BP12", "url": "https://www.uniprot.org/uniprotkb/E1BP12" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1BP12", "url": "https://www.uniprot.org/uniprotkb/E1BP12" } ], "pmid": "" }, { "name": "regulation of angiogenesis", "id": "GO:0045765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045765", "evidence": [ { "database": "UniProtKB", "id": "E1BP12", "url": "https://www.uniprot.org/uniprotkb/E1BP12" } ], "pmid": "" }, { "name": "axon development", "id": "GO:0061564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061564", "evidence": [ { "database": "UniProtKB", "id": "E1BP12", "url": "https://www.uniprot.org/uniprotkb/E1BP12" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 270, "end_pos": 272, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BP12-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 355, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BP12-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BP12" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 270, "end_pos": 272 }, { "start_pos": 52, "end_pos": 54 }, { "start_pos": 86, "end_pos": 88 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BP25-1", "uniprot_ac": "E1BP25", "uniprot_id": "E1BP25_BOVIN", "mass": { "chemical_mass": 100841.0, "monoisotopic_mass": 100841.0 }, "refseq": { "ac": "NP_001137574", "name": "urea transporter 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137574" }, "gene_names": [ { "name": "SLC14A2", "type": "recommended", "evidence": [ { "id": "E1BP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP25" } ] }, { "name": "SLC14A2", "type": "synonym", "evidence": [ { "id": "NP_001137574", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137574" } ] } ], "protein_names": [ { "name": "Urea transporter 1", "type": "recommended", "evidence": [ { "id": "E1BP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP25/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 14 member 1", "type": "synonym", "evidence": [ { "id": "E1BP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP25/entry#names_and_taxonomy" } ] }, { "name": "Urea transporter B", "type": "synonym", "evidence": [ { "id": "E1BP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP25/entry#names_and_taxonomy" } ] }, { "name": "Urea transporter, erythrocyte", "type": "synonym", "evidence": [ { "id": "E1BP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP25/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 14 (urea transporter), member 2", "type": "synonym", "evidence": [ { "id": "NP_001137574", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137574" } ] }, { "name": "urea transporter 2", "type": "synonym", "evidence": [ { "id": "NP_001137574", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137574" } ] } ], "function": [ { "annotation": "BUT-B2-mediated transepithelial urea transport was constitutively activated and unaffected by known regulators of renal UT-A urea transporters.", "evidence": [ { "database": "RefSeq", "id": "NP_001137574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137574" }, { "database": "PubMed", "id": "19474392", "url": "https://glygen.org/publication/PubMed/19474392" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP25", "url": "https://www.uniprot.org/uniprotkb/E1BP25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC14A2", "url": "https://www.uniprot.org/uniprotkb/E1BP25", "locus": { "chromosome": "24", "start_pos": 45400464, "end_pos": 45329690, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002099", "url": "https://www.ensembl.org/id/ENSBTAG00000002099" } ] } } ], "crossref": [ { "id": "E1BP25", "url": "https://alphafold.ebi.ac.uk/entry/E1BP25", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002099", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002099", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "537150", "url": "https://www.ncbi.nlm.nih.gov/gene/537150", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537150", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537150", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DPFPYQY", "url": "https://omabrowser.org/oma/group/DPFPYQY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BP25", "url": "https://www.orthodb.org/?gene=E1BP25", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10464", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10464", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10464:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10464:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03253", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03253", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-549127", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-549127", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001137574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137574", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "32799", "url": "https://www.rhea-db.org/rhea/32799", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BP25", "url": "https://www.uniprot.org/uniprotkb/E1BP25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP25-1", "url": "https://www.uniprot.org/uniprotkb/E1BP25-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDAHTHSSPLLAEPLSSKYKLYEFEFPSPGCSPNSQDAHPALPLLEMPEEKDLRSSNEESHIVKIEKPNEKDTRRETGAAPQDSAGQGGISLFQAVGYLTGEMKEYRSWLKDKPLAFQFTDWVLRGAAQVMFANNPLSGFIIFIGLLIQNPWWTITGGLGTVVSTLTALILSQDRAAIASGLHGYNGMLVGMLIAVFSEKLDYYWWLLLPVTLTAMSCPVFSSALSSIFSKWDLPVFTLPFNLAVTLYLAATGHYNLFFPTTLVEPVSSVPNITWSEIEMPLLLQAIPVGVGQVYGCDNPWTGGVFLVALFICSPLICLHAAIGSIVGLLAALTVATPFKTIYLGLWSYNSVLSCIAIGGMFYALTWQTHLLALVCALFCAYMGAALTNIMSVVGVPPGTWPFCLSTLTFLLLTTNNPTIYKLPLSRVTYPEANRIYYLTVKSGEEEKSSSGNTEAEPPSTSPKADEGSEAVLPKPRNVFHIEWSSIHRRSKVFGKGEQQERHPKDPSPRLYRKPTVELLALETMEDSSEIKVETGISKTSWIRSSLATIGKRIRKALGYITGEMKECGQGLKDKSPVFQFLDWVLRGTSQVMFVNNPLSGILIVLGLFIQNPWWAISGCLGTVVSTLTALILSQDKSAIAAGLHGYNGVLVGLLMAVFSDKGDYFWWLLLPVIVMSMSCPILSSALGTIFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTTLLQPVSSVPNITWSEIQVPLLLRAIPVGIGQVYGCDNPWTGGIFLIALFISSPLICLHAAIGSTIGMLAALTLATPFDSIYFGLCGFNSSLACIAIGGMFYVITWQTHLLAIACALFTAYLGTALANMLSVCGLPPCTWPFCFSALTFLLLTTNNPAIYKLPLSRVTYPEANRIYHLSQEKNRRASTITKYQAYDVS", "length": 922, "header": "tr|E1BP25-1|E1BP25_BOVIN Isoform 1 of Urea transporter 1 OS=Bos taurus OX=9913 GN=SLC14A2 PE=3 SV=3 CANONICAL=E1BP25-1" }, "isoforms": [ { "isoform_ac": "E1BP25-1", "url": "https://www.uniprot.org/uniprotkb/E1BP25/entry", "sequence": { "sequence": "MSDAHTHSSPLLAEPLSSKYKLYEFEFPSPGCSPNSQDAHPALPLLEMPEEKDLRSSNEESHIVKIEKPNEKDTRRETGAAPQDSAGQGGISLFQAVGYLTGEMKEYRSWLKDKPLAFQFTDWVLRGAAQVMFANNPLSGFIIFIGLLIQNPWWTITGGLGTVVSTLTALILSQDRAAIASGLHGYNGMLVGMLIAVFSEKLDYYWWLLLPVTLTAMSCPVFSSALSSIFSKWDLPVFTLPFNLAVTLYLAATGHYNLFFPTTLVEPVSSVPNITWSEIEMPLLLQAIPVGVGQVYGCDNPWTGGVFLVALFICSPLICLHAAIGSIVGLLAALTVATPFKTIYLGLWSYNSVLSCIAIGGMFYALTWQTHLLALVCALFCAYMGAALTNIMSVVGVPPGTWPFCLSTLTFLLLTTNNPTIYKLPLSRVTYPEANRIYYLTVKSGEEEKSSSGNTEAEPPSTSPKADEGSEAVLPKPRNVFHIEWSSIHRRSKVFGKGEQQERHPKDPSPRLYRKPTVELLALETMEDSSEIKVETGISKTSWIRSSLATIGKRIRKALGYITGEMKECGQGLKDKSPVFQFLDWVLRGTSQVMFVNNPLSGILIVLGLFIQNPWWAISGCLGTVVSTLTALILSQDKSAIAAGLHGYNGVLVGLLMAVFSDKGDYFWWLLLPVIVMSMSCPILSSALGTIFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTTLLQPVSSVPNITWSEIQVPLLLRAIPVGIGQVYGCDNPWTGGIFLIALFISSPLICLHAAIGSTIGMLAALTLATPFDSIYFGLCGFNSSLACIAIGGMFYVITWQTHLLAIACALFTAYLGTALANMLSVCGLPPCTWPFCFSALTFLLLTTNNPAIYKLPLSRVTYPEANRIYHLSQEKNRRASTITKYQAYDVS", "length": 922, "header": "tr|E1BP25-1|E1BP25_BOVIN Isoform 1 of Urea transporter 1 OS=Bos taurus OX=9913 GN=SLC14A2 PE=3 SV=3 CANONICAL=E1BP25-1" }, "locus": { "chromosome": "24", "start_pos": 45399913, "end_pos": 45329690, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002712.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002712.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002712.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002712.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Novel bUT-B2 urea transporter isoform is constitutively activated.", "journal": "American journal of physiology. Regulatory, integrative and comparative physiology", "date": "2009-08", "authors": "Tickle P, Thistlethwaite A, Smith C P, Stewart G S", "evidence": [ { "database": "RefSeq", "id": "NP_001137574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137574" } ], "reference": [ { "type": "PubMed", "id": "19474392", "url": "https://glygen.org/publication/PubMed/19474392" } ] } ], "pathway": [ { "id": "bta:537150", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537150", "resource": "KEGG Pathway" }, { "id": "R-BTA-549127", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-549127", "resource": "Reactome", "description": "SLC-mediated transport of organic cations" } ], "orthologs": [ { "uniprot_canonical_ac": "Q15849-1", "protein_name": "Urea transporter 2", "gene_name": "SLC14A2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDPHSSPLLPEPLSSRYKLYEAEFTSPSWPSTSPDTHPALPLLEMPEEKDLRSSNEDSHIVKIEKLNERSKRKDDGVAHRDSAGQRCICLSKAVGYLTGDMKEYRIWLKDKHLALQFIDWVLRGTAQVMFINNPLSGLIIFIGLLIQNPWWTITGGLGTVVSTLTALALGQDRSAIASGLHGYNGMLVGLLMAVFSEKLDYYWWLLFPVTFTAMSCPVLSSALNSIFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTTLVEPVSSVPNITWTEMEMPLLLQAIPVGVGQVYGCDNPWTGGVFLVALFISSPLICLHAAIGSIVGLLAALSVATPFETIYTGLWSYNCVLSCIAIGGMFYALTWQTHLLALICALFCAYMEAAISNIMSVVGVPPGTWAFCLATIIFLLLTTNNPAIFRLPLSKVTYPEANRIYYLTVKSGEEEKAPSGGGGEHPPTAGPKVEEGSEAVLSKHRSVFHIEWSSIRRRSKVFGKGEHQERQNKDPFPYRYRKPTVELLDLDTMEESSEIKVETNISKTSWIRSSMAASGKRVSKALSYITGEMKECGEGLKDKSPVFQFFDWVLRGTSQVMFVNNPLSGILIILGLFIQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGFHGYNGVLVGLLMAVFSDKGDYYWWLLLPVIIMSMSCPILSSALGTIFSKWDLPVFTLPFNITVTLYLAATGHYNLFFPTTLLQPASAMPNITWSEVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLIALFISSPLICLHAAIGSTMGMLAALTIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPAIYKLPLSKVTYPEANRIYYLSQERNRRASIITKYQAYDVS", "length": 920 }, "evidence": [ { "id": "E1BP25", "url": "https://omabrowser.org/oma/group/E1BP25/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q62668-1", "protein_name": "Urea transporter 2", "gene_name": "Slc14a2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSDHPLKEMSDNNRSPPLPEPLSSRYKLYESELSSPTWPSSSQDTHPALPLLEMPEEKDLRSSDEDSHIVKIEKPNERSKRRESELPRRASAGRGAFSLFQAVSYLTGDMKECKNWLKDKPLVLQFLDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQDRSAIASGLHGYNGMLVGLLVAVFSEKLDYYWWLLFPVTFASMACPVISSALSTVFAKWDLPVFTLPFNIALTLYLAATGHYNLFFPTTLVKPASSAPNITWSEIEMPLLLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSCVAIGGMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAFCLSTLTFLLLTSNNPGIHKLPLSKVTYPEANRIYFLTAKRSDEQKPPNGGGGEQSHGGGQRKAEEGSETVFPRRKSVFHIEWSSIRRRSKVFGKSEHQERQTKEPLPYLYRKPTVELLDLNTMEESSEIKVETNTTRTTWIQSSMIAGGKRVSKALSYITGEMKECGEGLKDKSPVFQFLDWVLRGTSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLVGLLMAVFSDKGNYYWWLLLPVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTKLLQPAVTTPNITWSDVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLVALFVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPGIYKLPLSKVTYPEANRIYFLSQEKNRRASMITKYQAYDVS", "length": 929 }, "evidence": [ { "id": "E1BP25", "url": "https://omabrowser.org/oma/group/E1BP25/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8R4T9-1", "protein_name": "Urea transporter 2", "gene_name": "Slc14a2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDHHPLKEMSDSNSSPLLPEPLSSRYKLYESELSSPTWPSSSQDTHPALPLLEMPEEKDLRSSDEDSHIVKIEKPNERNKRRESEVSRRASAGRGGFSLFQAVSYLTGDMKECKNWLKDKPLVLQFLDWVLRGAAQVMFVNNPISGLIIFIGLLIQNPWWTIAGTLGTVASTLAALALSQDRSAIASGLHGYNGMLVGLLMAVFSEKLDYYWWLLFPVTFTSMACPIISSALSTIFAKWDLPVFTLPFNIALTLYLAATGHYNLFFPTTLIKPASAAPNITWTEIEMPLLLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYLGLWSYNCVLSCIAIGGMFYALTWQTHLLALVCALFCAYMGAALSNTMAVVGVPSGTWAFCLSTLTFLLLTSNNTGIYKLPLSKVTYPEANRIYFLTVRRSEEEKSPNGGSGEQSHGSGQWKAEESSETVLPRRRSVFHIEWSSIRRRSKVFGKGEHQERQTKEPLPCPYRKPTVELFDLDTMEESTEIKVEANTARTSWIQSSMVAGGKRVSKALSYITGEMKECGEGLKDKSPVFQFLDWVLRGMSQVMFVNNPLSGILIVLGLFVQNPWWAISGCLGTVMSTLTALILSQDKSAIAAGLHGYNGVLVGLLMAVFSDKGNYYWWLLLPVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLAATGHHNLFFPTTLLQPATTTPNITWSDIQVSLLLRAIPVGIGQVYGCDNPWTGGIFLVALFISSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTSNNPAIYKLPLSKVTYPEANRIYFLSQEKNRRASTITKYQAYDVS", "length": 930 }, "evidence": [ { "id": "E1BP25", "url": "https://omabrowser.org/oma/group/E1BP25/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "urea transmembrane transport", "id": "GO:0071918", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071918", "evidence": [ { "database": "UniProtKB", "id": "E1BP25", "url": "https://www.uniprot.org/uniprotkb/E1BP25" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "E1BP25", "url": "https://www.uniprot.org/uniprotkb/E1BP25" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "urea transmembrane transporter activity", "id": "GO:0015204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015204", "evidence": [ { "database": "UniProtKB", "id": "E1BP25", "url": "https://www.uniprot.org/uniprotkb/E1BP25" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 735, "end_pos": 737, "annotation": "n_glycosylation_sequon" }, { "start_pos": 813, "end_pos": 815, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "32799", "name": "", "equation": "urea(in) = urea(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "32799", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32799" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BP25-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 922, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BP25-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BP25" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 273, "end_pos": 275 }, { "start_pos": 735, "end_pos": 737 }, { "start_pos": 813, "end_pos": 815 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BP61-1", "uniprot_ac": "E1BP61", "uniprot_id": "E1BP61_BOVIN", "mass": { "chemical_mass": 70163.0, "monoisotopic_mass": 70163.0 }, "refseq": { "ac": "NP_001192359", "name": "solute carrier family 23 member 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192359" }, "gene_names": [ { "name": "SLC23A2", "type": "recommended", "evidence": [ { "id": "E1BP61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP61" } ] }, { "name": "SLC23A2", "type": "synonym", "evidence": [ { "id": "NP_001192359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192359" } ] } ], "protein_names": [ { "name": "Solute carrier family 23 member 2", "type": "synonym", "evidence": [ { "id": "E1BP61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP61/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 23 (nucleobase transporters), member 1", "type": "synonym", "evidence": [ { "id": "NP_001192359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192359" } ] }, { "name": "solute carrier family 23 member 2", "type": "synonym", "evidence": [ { "id": "NP_001192359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192359" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP61", "url": "https://www.uniprot.org/uniprotkb/E1BP61" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC23A2", "url": "https://www.uniprot.org/uniprotkb/E1BP61", "locus": { "chromosome": "13", "start_pos": 47209404, "end_pos": 47348038, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032366", "url": "https://www.ensembl.org/id/ENSBTAG00000032366" } ] } } ], "crossref": [ { "id": "E1BP61", "url": "https://alphafold.ebi.ac.uk/entry/E1BP61", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032366", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032366", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "783536", "url": "https://www.ncbi.nlm.nih.gov/gene/783536", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006042", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006042", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006043", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006043", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783536", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783536", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MVVSMTE", "url": "https://omabrowser.org/oma/group/MVVSMTE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BP61", "url": "https://www.orthodb.org/?gene=E1BP61", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00860", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00860", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-196836", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196836", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192359", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BP61", "url": "https://www.uniprot.org/uniprotkb/E1BP61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP61-1", "url": "https://www.uniprot.org/uniprotkb/E1BP61-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMGIGKNTTSKSMEAGSSAEGKYEDEAKHPSFFTLPVVINGGATSSGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLDKWKCNTTDVSVANGTTALLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLKYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAPWFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPSPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQYGAALMLALGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLVTGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIRKWKKGVGKGSKSLDGMESYDLPFGMNIIKKYRCFSYLPISPTFAGYTWKGLGKSASSRSSDEDSQATV", "length": 650, "header": "tr|E1BP61-1|E1BP61_BOVIN Isoform 1 of Solute carrier family 23 member 2 OS=Bos taurus OX=9913 GN=SLC23A2 PE=3 SV=3 CANONICAL=E1BP61-1" }, "isoforms": [ { "isoform_ac": "E1BP61-1", "url": "https://www.uniprot.org/uniprotkb/E1BP61/entry", "sequence": { "sequence": "MMGIGKNTTSKSMEAGSSAEGKYEDEAKHPSFFTLPVVINGGATSSGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLDKWKCNTTDVSVANGTTALLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLKYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAPWFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPSPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQYGAALMLALGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLVTGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIRKWKKGVGKGSKSLDGMESYDLPFGMNIIKKYRCFSYLPISPTFAGYTWKGLGKSASSRSSDEDSQATV", "length": 650, "header": "tr|E1BP61-1|E1BP61_BOVIN Isoform 1 of Solute carrier family 23 member 2 OS=Bos taurus OX=9913 GN=SLC23A2 PE=3 SV=3 CANONICAL=E1BP61-1" }, "locus": { "chromosome": "13", "start_pos": 47294702, "end_pos": 47209511, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039356.5", "url": "https://www.ensembl.org/id/ENSBTAT00000039356.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039151.5", "url": "https://www.ensembl.org/id/ENSBTAP00000039151.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 250, "start_aa": "Thr", "end_pos": 250, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr250", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:783536", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783536", "resource": "KEGG Pathway" }, { "id": "R-BTA-196836", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196836", "resource": "Reactome", "description": "Vitamin C (ascorbate) metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M9PLA9-1", "protein_name": "Solute carrier family 23 member 2 isoform X1", "gene_name": "slc23a2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MCELDELAGQSVEHEIVLTGRSAVFLPEREWRRAADPQSVEDELSGGMGVGKNTTSKSMDSTTEPGKYEEENKHSAHFYPIPVVNGVVQTAGDQDAEDTQLMAIYAKDSQTEDKCSISDTVDSADSIDAGRIDMIYTIEDTPPWYLCVFLGLQHYLTCFSGTIAVPFLLAEAMCVGFDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLEKWKCNATATLFLNSTELPHTEDIWYPRIREIQGAIIVSSLIEVVIGALGLPGVLLKYIGPLTITPTVTLIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNIHLPLPVYKSKKGWTSYRLQLFKMFPIIMAILVSWFLCFIFTVTDVFPPEKDKYGFYARTDARQGILAAAPWFKIPYPFQWGLPTVTAAGVIGMLSAVVASIIESIGDYYACARLSGAPPPPIHAINRGIFTEGLSCVLDGVFGTGNGSTSSSPNIGVLGITKVGSRRVIQYGAAFMLLLGMVGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFVDLNSSRNLFVLGFSIFFGLVLPSYLKENPLVTGIVQIDQVLNVLLTTAMFVGGSVAFVLDNTIPGTAEERGIRKMNRGNSSSKRERMESYDLPIGMDFLRRHRIFQYLPISPTFAGYQWSIFTHSCRNRKDESMPAKPELGESGV", "length": 698 }, "evidence": [ { "id": "E1BP61", "url": "https://omabrowser.org/oma/group/E1BP61/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q54NF0-1", "protein_name": "Xanthine/uracil permease family protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFINRNKKDIKNGLKIIINGIKNYFPNYELKQDYSNGVLPDERIPWGPTILLAFQHVLAMFGSTVVGPLLMGFSPNTALLFSGVGTVIFFICTGGKVPSYLGSSFAFIGVVNSATGFVYIAGSNSSNPNIAQASGGILSCGLVYLGISLIVIFVGTKWIEVLTPPVVTGSVVVAIGFHLSTSAIHQVATSAFEAWMALVTVLCVCMVTCYAPGPFKRLPILIGGLSSYLLYFLFGLGEIGPGIDFSGVGNSRWIGSPPITAPVFESTYISLIAPIAIILAAENIGHLKAVSTMTGKNLDYMIGRTFLGDSIACILAGSCGSIGTTTYAENIGVMSITKIFSTLSFLIAAFIAIILGCLPIFGAIIQTIPPGIFGGLSIVLFGITGITGAKLWVEAQVDFSKPRNLLSAGIAIVLGTGMIDVVVQWGNLKIDGIGCATFSSIILYQLLRDDWSKIFKLIISKIKIKNNNNNKTIQKETNTEFQELDNLNNPNTTIDLINSNNNNNNNNNNNNNNNNNKNNNNNNNEDINNNSNTADLHDNNYISN", "length": 544 }, "evidence": [ { "id": "E1BP61", "url": "https://omabrowser.org/oma/group/E1BP61/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8GZD4-1", "protein_name": "Nucleobase-ascorbate transporter 3", "gene_name": "NAT3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVETGHHHQHPPAPAAAGHPPVPSMAMARNMGTTWPPAEQLHHLQYCIHSNPSWHETVVLAFQHYIVMLGTTVLIANTLVSPMGGDPGDKARVIQTILFMSGINTLLQTLIGTRLPTVMGVSFAYVLPVLSIIRDYNNGQFDSEKQRFRHTMRTVQGSLIISSFVNIIIGYGQAWGNLIRIFSPIIVVPVVSVVSLGLFLRGFPLLANCVEIGLPMLILLIITQQYLKHAFSRISMILERYALLVCLAIIWAFAAILTVSGAYNNVSTATKQSCRTDRAFLMSSAPWIRIPYPFQWGTPIFKASHVFGMFGAAIVASAESTGVFFAASRLAGATAPPAHVVSRSIGLQGIGVLLEGIFGSITGNTASVENVGLLGLTRIGSRRVVQVSTFFMIFFSIFGKFGAFFASIPLPIFAGVYCILLGIVVAVGISFIQFTDTNSMRNMYVIGVSLFLSLSIAQYFLANTSRAGYGPVRTAGGWFNDILNTIFASAPLVATILATILDNTLEARHASDDARGIPWWKPFQHRNGDGRNDEFYSMPLRINELMPTRFL", "length": 551 }, "evidence": [ { "id": "E1BP61", "url": "https://omabrowser.org/oma/group/E1BP61/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9EPR4-1", "protein_name": "Solute carrier family 23 member 2", "gene_name": "Slc23a2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMGIGKNTASKSVEAGGSTEGKYEEEAKHSNFFTLPVVINGGATSSGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLADAMCVGDDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLDKWKCNTTEITVANGTAELLEHIWHPRIQEIQGAIIMSSLIEVVIGLLGLPGALLRYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKFQLFKMFPIILAILVSWLLCFIFTVTDVFPSNSTDYGYYARTDARKGVLLVAPWFKVPYPFQWGMPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQYGAALMLGLGMVGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLVTGITGIDQILNVLLTTAMFVGGCVAFILDNTIPGTPEERGIKKWKKGVSKGSKSLDGMESYNLPFGMNIIKKYRCFSYLPISPTFAGYTWKGFGKSENSRSSDKDSQATV", "length": 648 }, "evidence": [ { "id": "E1BP61", "url": "https://omabrowser.org/oma/group/E1BP61/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UGH3-1", "protein_name": "Solute carrier family 23 member 2", "gene_name": "SLC23A2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGATSSGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLDKWKCNTTDVSVANGTAELLHTEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLKYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAPWFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQCGAALMLALGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLVTGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIRKWKKGVGKGNKSLDGMESYNLPFGMNIIKKYRCFSYLPISPTFVGYTWKGLRKSDNSRSSDEDSQATG", "length": 650 }, "evidence": [ { "id": "E1BP61", "url": "https://omabrowser.org/oma/group/E1BP61/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VH02-1", "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG6293", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MELNNVTIEDATDASKSYSQAANTPPSNEKPKPQLLYAINDNPPWYLSIFLAFQHYLTMIGAIVSIPFILTPALCMSDEDANRGIIISTMIFVTGIVTYFQATWGVRLPIVQGGTISFLVPTLAILALPQWKCPEQAVMDAMDEAEREELWQVRMRELSGAIAVSAMVQVILGYTGLVGKILKYVTPLTIVPTVSLVGLTLFEHAAETASKHWGIAVGTTGMLTLFSQIMSNVPVPILAYRKGHGLEIRQFQLFRLFPVLLTIMIMWGLCGILTATDVFPPSHPSRTDVRLNVLTSAKWFYVPYPGQFGWPSVTLSGVLGMLAGVLACTVESLSYYPTVSQMSGAHSPPLHAINRGIGTEGFGTVLAGLWGAGNGTNTFGENVGAIGVTKIGSRRVIQWAALIMVLQGVIGKFGAIFILIPDSVVGGIFCVMFGMIIAFGLSTLQYVDLRSARNLYILGLSIFFPMVLCRWMQKNPGAIDTGNKTVDSTLSVLLGTTILVGGVLGCLLDNIIPGTPEERGLIDWANEMPLGDDNVNDGTATDYDFPLGMDAIRRWKWTYYIPFMPTYKLQKQS", "length": 573 }, "evidence": [ { "id": "E1BP61", "url": "https://omabrowser.org/oma/group/E1BP61/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9WTW8-1", "protein_name": "Solute carrier family 23 member 2", "gene_name": "Slc23a2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMGVGKNTSKSVEVGGSTEGKYEEEAKRPDFFTLPVVINGGATSSGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLADAMCVGDDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLDKWKCNTTEITVANGTAELLEHIWHPRIQEIQGAIIMSSLIEVVIGLLGLPGALLRYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPSNSTDYGYYARTDARKGVLLVAPWFKVPYPFQWGMPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGVFGTGNGSTSSSPNIGVLGITKVGSRRVIQYGAALMLGLGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLVTGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIKKWKKGVSKGNKSLDGMESYNLPFGMNIIKKYRCFSYLPISPTFAGYTWKGFGKSENRRSSDKDSQATV", "length": 647 }, "evidence": [ { "id": "E1BP61", "url": "https://omabrowser.org/oma/group/E1BP61/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "L-ascorbate:sodium symporter activity", "id": "GO:0008520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008520", "evidence": [ { "database": "UniProtKB", "id": "E1BP61", "url": "https://www.uniprot.org/uniprotkb/E1BP61" } ], "pmid": "" }, { "name": "L-ascorbic acid transmembrane transporter activity", "id": "GO:0015229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015229", "evidence": [ { "database": "UniProtKB", "id": "E1BP61", "url": "https://www.uniprot.org/uniprotkb/E1BP61" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "L-ascorbic acid transmembrane transport", "id": "GO:0015882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015882", "evidence": [ { "database": "UniProtKB", "id": "E1BP61", "url": "https://www.uniprot.org/uniprotkb/E1BP61" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BP61", "url": "https://www.uniprot.org/uniprotkb/E1BP61" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "E1BP61", "url": "https://www.uniprot.org/uniprotkb/E1BP61" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "E1BP61", "url": "https://www.uniprot.org/uniprotkb/E1BP61" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 436, "end_pos": 438, "annotation": "n_glycosylation_sequon" }, { "start_pos": 512, "end_pos": 514, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BP61-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 650, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BP61-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BP61" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 250 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 188, "end_pos": 190 }, { "start_pos": 196, "end_pos": 198 }, { "start_pos": 436, "end_pos": 438 }, { "start_pos": 512, "end_pos": 514 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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split-related protein HELT", "type": "recommended", "evidence": [ { "id": "E1BP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP66/entry#names_and_taxonomy" } ] }, { "name": "HES/HEY-like transcription factor", "type": "synonym", "evidence": [ { "id": "E1BP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP66/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP66", "url": "https://www.uniprot.org/uniprotkb/E1BP66" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HELT", "url": "https://www.uniprot.org/uniprotkb/E1BP66", "locus": { "chromosome": "27", "start_pos": 15390968, "end_pos": 15389178, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014704", "url": "https://www.ensembl.org/id/ENSBTAG00000014704" } ] } } ], "crossref": [ { "id": "E1BP66", "url": "https://alphafold.ebi.ac.uk/entry/E1BP66", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014704", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014704", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11408", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11408", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10985", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10985", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07527", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07527", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BP66", "url": "https://www.uniprot.org/uniprotkb/E1BP66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP66-1", "url": "https://www.uniprot.org/uniprotkb/E1BP66-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDKLKERKRTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQSSGKLEKAEILEMTVQYLRALHSADFPRGREKAELLAEFANYFHYGYHECMKNLVHYLTTVERMETKDTKYARILAFLQSKARLGTEPAFQPLGSLPEPDFSYQLHPAGPEFAGHSPGEASVFPQGGAGPFAWPHGASRSPALPYLPSAPVPLPSPAPQHSAFLAPGQGLDRHYLNLIGHAHPTALNLHAPQHPPVL", "length": 241, "header": "tr|E1BP66-1|E1BP66_BOVIN Isoform 1 of Hairy and enhancer of split-related protein HELT OS=Bos taurus OX=9913 GN=HELT PE=3 SV=3 CANONICAL=E1BP66-1" }, "isoforms": [ { "isoform_ac": "E1BP66-1", "url": "https://www.uniprot.org/uniprotkb/E1BP66/entry", "sequence": { "sequence": "MSDKLKERKRTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQSSGKLEKAEILEMTVQYLRALHSADFPRGREKAELLAEFANYFHYGYHECMKNLVHYLTTVERMETKDTKYARILAFLQSKARLGTEPAFQPLGSLPEPDFSYQLHPAGPEFAGHSPGEASVFPQGGAGPFAWPHGASRSPALPYLPSAPVPLPSPAPQHSAFLAPGQGLDRHYLNLIGHAHPTALNLHAPQHPPVL", "length": 241, "header": "tr|E1BP66-1|E1BP66_BOVIN Isoform 1 of Hairy and enhancer of split-related protein HELT OS=Bos taurus OX=9913 GN=HELT PE=3 SV=3 CANONICAL=E1BP66-1" }, "locus": { "chromosome": "27", "start_pos": 15390965, "end_pos": 15389178, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019570.5", "url": "https://www.ensembl.org/id/ENSBTAT00000019570.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019570.4", "url": "https://www.ensembl.org/id/ENSBTAP00000019570.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "E1BP66", "url": "https://www.uniprot.org/uniprotkb/E1BP66" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BP66", "url": "https://www.uniprot.org/uniprotkb/E1BP66" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "E1BP66", "url": "https://www.uniprot.org/uniprotkb/E1BP66" } ], "pmid": "" }, { "name": "anterior/posterior pattern specification", "id": "GO:0009952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009952", "evidence": [ { "database": "UniProtKB", "id": "E1BP66", "url": "https://www.uniprot.org/uniprotkb/E1BP66" } ], "pmid": "" }, { "name": "regulation of neurogenesis", "id": "GO:0050767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050767", "evidence": [ { "database": "UniProtKB", "id": "E1BP66", "url": "https://www.uniprot.org/uniprotkb/E1BP66" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BP66", "url": "https://www.uniprot.org/uniprotkb/E1BP66" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "E1BP66", "url": "https://www.uniprot.org/uniprotkb/E1BP66" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BP66", "url": "https://www.uniprot.org/uniprotkb/E1BP66" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "E1BP66", "url": "https://www.uniprot.org/uniprotkb/E1BP66" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "E1BP66", "url": "https://www.uniprot.org/uniprotkb/E1BP66" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BP66", "url": "https://www.uniprot.org/uniprotkb/E1BP66" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BP66", "url": "https://www.uniprot.org/uniprotkb/E1BP66" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BP66-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 241, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BP66-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BP66" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP66" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 10, "end_pos": 65, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BP66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP66" }, { "id": "PS51054", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51054" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Orange", "eco_id": "ECO_0000259", "start_pos": 87, "end_pos": 122, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"MTSREQLVQHVLQELQEAVESEGLEGLVGAALEAKQVLSSFALPTRRGGGPGPQVLEVDSVALSLYPEDAPRNMLPLVCQGEGSLLFEAASLLLWGDAGLSLELRARTVVEMLLHRHYYLQGMIDSKVMLQAVRYSLRSEESPEMTSLPSATLEAIFDADVKATCFPSSFSNVWHLYALASVVQRNIYSIYPLRNLKIRPYFNRVIRPRRCDHTPATLHIMWAGQPLSGHLFRHQYFAPVVGLEEVEAESAHPGPAPLPPPAKTLELLNREPGLSYSHLGEHSSVTKSTFYRWRRQSQEHRQKVATRFSAKHFLQDSFHRGGVVPLQQFLQRFPEISRSTYYAWKHELVGSGACQALTPTEELTKLPERQVAEGLGCSSTAASSPGVVFMQRAKLYLEHCIALNTLVPYRCFKRRFPGISRSTYYNWRRKALRRNPSFKPVPALLESGPPQPVPVGEKALLPWKGGEVGEGAAKATGGGPPAPRAFLPLRVPLSRWQRRLRRAARKQVLGGHLPFCRFRLRYPSLSPSSFWVWKSLARSWPGSLSKLHIPAPTLGRGSRKEAEEKEAGRNVIAAVAPPEGTWPMAASPGQDPNGQVLVMDMLATTKFKAQAKLFLQKRFQSKSFPSYKEFSTLFPLTARSTYYMWKRALYDGLTLVDG", "length": 658, "header": "sp|E1BP92-1|VRTN_BOVIN Isoform 1 of Vertnin OS=Bos taurus OX=9913 GN=VRTN PE=3 SV=1 CANONICAL=E1BP92-1" }, "isoforms": [ { "isoform_ac": "E1BP92-1", "url": "https://www.uniprot.org/uniprotkb/E1BP92/entry#E1BP92-1", "sequence": { "sequence": "MTSREQLVQHVLQELQEAVESEGLEGLVGAALEAKQVLSSFALPTRRGGGPGPQVLEVDSVALSLYPEDAPRNMLPLVCQGEGSLLFEAASLLLWGDAGLSLELRARTVVEMLLHRHYYLQGMIDSKVMLQAVRYSLRSEESPEMTSLPSATLEAIFDADVKATCFPSSFSNVWHLYALASVVQRNIYSIYPLRNLKIRPYFNRVIRPRRCDHTPATLHIMWAGQPLSGHLFRHQYFAPVVGLEEVEAESAHPGPAPLPPPAKTLELLNREPGLSYSHLGEHSSVTKSTFYRWRRQSQEHRQKVATRFSAKHFLQDSFHRGGVVPLQQFLQRFPEISRSTYYAWKHELVGSGACQALTPTEELTKLPERQVAEGLGCSSTAASSPGVVFMQRAKLYLEHCIALNTLVPYRCFKRRFPGISRSTYYNWRRKALRRNPSFKPVPALLESGPPQPVPVGEKALLPWKGGEVGEGAAKATGGGPPAPRAFLPLRVPLSRWQRRLRRAARKQVLGGHLPFCRFRLRYPSLSPSSFWVWKSLARSWPGSLSKLHIPAPTLGRGSRKEAEEKEAGRNVIAAVAPPEGTWPMAASPGQDPNGQVLVMDMLATTKFKAQAKLFLQKRFQSKSFPSYKEFSTLFPLTARSTYYMWKRALYDGLTLVDG", "length": 658, "header": "sp|E1BP92-1|VRTN_BOVIN Isoform 1 of Vertnin OS=Bos taurus OX=9913 GN=VRTN PE=3 SV=1 CANONICAL=E1BP92-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "E1BP92", "url": "https://www.uniprot.org/uniprotkb/E1BP92" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BP92", "url": "https://www.uniprot.org/uniprotkb/E1BP92" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "E1BP92", "url": "https://www.uniprot.org/uniprotkb/E1BP92" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BP92", "url": "https://www.uniprot.org/uniprotkb/E1BP92" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BP92", "url": "https://www.uniprot.org/uniprotkb/E1BP92" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BP92-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 658, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BP92-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BP92" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BP94-1", "uniprot_ac": "E1BP94", "uniprot_id": "E1BP94_BOVIN", "mass": { "chemical_mass": 22584.0, "monoisotopic_mass": 22584.0 }, "refseq": { "ac": "XP_010811906", "name": "protein RD3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811906" }, "gene_names": [ { "name": "RD3", "type": "recommended", "evidence": [ { "id": "E1BP94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP94" } ] }, { "name": "RD3", "type": "synonym", "evidence": [ { "id": "XP_010811906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811906" } ] } ], "protein_names": [ { "name": "RD3 regulator of GUCY2D", "type": "synonym", "evidence": [ { "id": "E1BP94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP94/entry#names_and_taxonomy" } ] }, { "name": "protein RD3", "type": "synonym", "evidence": [ { "id": "XP_010811906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811906" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP94", "url": "https://www.uniprot.org/uniprotkb/E1BP94" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RD3", "url": "https://www.uniprot.org/uniprotkb/E1BP94", "locus": { "chromosome": "16", "start_pos": 71971167, "end_pos": 71957455, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024453", "url": "https://www.ensembl.org/id/ENSBTAG00000024453" } ] } } ], "crossref": [ { "id": "E1BP94", "url": "https://alphafold.ebi.ac.uk/entry/E1BP94", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024453", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024453", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "101906969", "url": "https://www.ncbi.nlm.nih.gov/gene/101906969", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR028092", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028092", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101906969", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101906969", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MNFRSRI", "url": "https://omabrowser.org/oma/group/MNFRSRI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BP94", "url": "https://www.orthodb.org/?gene=E1BP94", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28489", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28489", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28489:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28489:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14473", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14473", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010811906", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811906", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BP94", "url": "https://www.uniprot.org/uniprotkb/E1BP94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP94-1", "url": "https://www.uniprot.org/uniprotkb/E1BP94-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLLPWLRGNEAPPRPSPRSPAEMVLETLMVELAGQMREAERQQRERSHAVRKVCTRVDYSWLASAPRPAYDLSPGERLQLEDVCAKIHPAYCGPAILRFRQLVAEQEPEVQEVSRLFRSVLQEVLERMEEEEEAQRLTRQWSLRAPRGTLTTFRSRARIAPFASDIHTISEDVERDTPPPRAWSLPEFRARKED", "length": 195, "header": "tr|E1BP94-1|E1BP94_BOVIN Isoform 1 of RD3 regulator of GUCY2D OS=Bos taurus OX=9913 GN=RD3 PE=4 SV=1 CANONICAL=E1BP94-1" }, "isoforms": [ { "isoform_ac": "E1BP94-1", "url": "https://www.uniprot.org/uniprotkb/E1BP94/entry", "sequence": { "sequence": "MSLLPWLRGNEAPPRPSPRSPAEMVLETLMVELAGQMREAERQQRERSHAVRKVCTRVDYSWLASAPRPAYDLSPGERLQLEDVCAKIHPAYCGPAILRFRQLVAEQEPEVQEVSRLFRSVLQEVLERMEEEEEAQRLTRQWSLRAPRGTLTTFRSRARIAPFASDIHTISEDVERDTPPPRAWSLPEFRARKED", "length": 195, "header": "tr|E1BP94-1|E1BP94_BOVIN Isoform 1 of RD3 regulator of GUCY2D OS=Bos taurus OX=9913 GN=RD3 PE=4 SV=1 CANONICAL=E1BP94-1" }, "locus": { "chromosome": "16", "start_pos": 71971113, "end_pos": 71969177, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033923.4", "url": "https://www.ensembl.org/id/ENSBTAT00000033923.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033826.2", "url": "https://www.ensembl.org/id/ENSBTAP00000033826.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101906969", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101906969", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZR16-1", "protein_name": "RD3 regulator of GUCY2D", "gene_name": "RD3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLTPWLRWHAAPPRLSSRSPAEMVLETLMVELAGQMREAERQQWERSKAVRKICTGVDYSWLASAPRPAYDLSPGERLQLEDVCAKIHPSYCGPAILRFRQLMAEREPEVQEGSRLFRSVLQEVLERMKQEEAAHKLTRQWSLRPRGGLAPFKGRARIAPFASDIRTISEDVERDAPPPSRTWSMPEFRARKED", "length": 195 }, "evidence": [ { "id": "E1BP94", "url": "https://omabrowser.org/oma/group/E1BP94/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z7E9-1", "protein_name": "RD3 regulator of GUCY2D", "gene_name": "RD3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSLASWFRWNEPPNRISQRNPTEMVVETLMMELSWQIKQAEKQQRERENEYRKIKTGVDYGWLVSYPKQSYDISPGERLQLEDMCTKIHPSYCGPVILRFRQLIAEYEPEVQEVSRLFRSVLQEAVEKIKEEEDAKKLAKQWNTKNKTSLSLTTFKSRSKISPFISDIKTISEDVERGTQPTRRVWSMPEFRNAKDY", "length": 197 }, "evidence": [ { "id": "E1BP94", "url": "https://omabrowser.org/oma/group/E1BP94/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H2L4-1", "protein_name": "Protein RD3 isoform X1", "gene_name": "Rd3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSLTPWLRWNDTPPRLSARSPAEIVLETLMMELAGQMREVERQQRERRRAVRKICTGVDYSWLASAPRPSYDLSPGERLQLEDVCAKIHPSYCGPAILRFRQLLAEREPEVQDVARLFRSVLQEALEKTKQEEEAHKLTRQWSLRPRGSLSSFKTRARIAPFASDIRTISEDVERDAPPPPRTWSMPEFRAPQVD", "length": 195 }, "evidence": [ { "id": "E1BP94", "url": "https://omabrowser.org/oma/group/E1BP94/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "M0R688-1", "protein_name": "RD3 regulator of GUCY2D", "gene_name": "Rd3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLIPWLRWNDTPPRLSARSPAEMVLETLMMELAGQMREVERQQRERRSAVRKICTGVDYSWLASAPRPTYDISPGERLQLEDVCAKIHPSYCGPAILRFRQLLAEREPEVQEVARLFRSVLQEALEKMKQEEEAHKLTRQWSLRPRGSLSSFKTRARIAPFASDIRTISEDVERDAPPPPRTWSMPEFRAPQAD", "length": 195 }, "evidence": [ { "id": "E1BP94", "url": "https://omabrowser.org/oma/group/E1BP94/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7Z3Z2-1", "protein_name": "Protein RD3", "gene_name": "RD3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLISWLRWNEAPSRLSTRSPAEMVLETLMMELTGQMREAERQQRERSNAVRKVCTGVDYSWLASTPRSTYDLSPIERLQLEDVCVKIHPSYCGPAILRFRQLLAEQEPEVQEVSQLFRSVLQEVLERMKQEEEAHKLTRQWSLRPRGSLATFKTRARISPFASDIRTISEDVERDTPPPLRSWSMPEFRAPKAD", "length": 195 }, "evidence": [ { "id": "E1BP94", "url": "https://omabrowser.org/oma/group/E1BP94/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BRE0-1", "protein_name": "Protein RD3", "gene_name": "Rd3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLIPWLRWNDTPPRLSARTPAEMVLETLMMELAGQMREVERQQRERRSAVRKICTGVDYSWLANTPRPTYDISPGERLQLEDVCAKIHPSYCGPAILRFRQLLAEREPEVQEVARLFRSVLQEALEKMKQEEEAHKLTRQWSLRPRGSLSSFKTRARIAPFASDIRTISEDVERDAPPPPRTWSMPEFRAPQAD", "length": 195 }, "evidence": [ { "id": "E1BP94", "url": "https://omabrowser.org/oma/group/E1BP94/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BP94", "url": "https://www.uniprot.org/uniprotkb/E1BP94" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "E1BP94", "url": "https://www.uniprot.org/uniprotkb/E1BP94" } ], "pmid": "" }, { "name": "photoreceptor inner segment", "id": "GO:0001917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001917", "evidence": [ { "database": "UniProtKB", "id": "E1BP94", "url": "https://www.uniprot.org/uniprotkb/E1BP94" } ], "pmid": "" }, { "name": "cone photoreceptor outer segment", "id": "GO:0120199", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120199", "evidence": [ { "database": "UniProtKB", "id": "E1BP94", "url": "https://www.uniprot.org/uniprotkb/E1BP94" } ], "pmid": "" }, { "name": "rod photoreceptor outer segment", "id": "GO:0120200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120200", "evidence": [ { "database": "UniProtKB", "id": "E1BP94", "url": "https://www.uniprot.org/uniprotkb/E1BP94" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "E1BP94", "url": "https://www.uniprot.org/uniprotkb/E1BP94" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "E1BP94", "url": "https://www.uniprot.org/uniprotkb/E1BP94" } ], "pmid": "" }, { "name": "retina development in camera-type eye", "id": "GO:0060041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060041", "evidence": [ { "database": "UniProtKB", "id": "E1BP94", "url": "https://www.uniprot.org/uniprotkb/E1BP94" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BP94-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 195, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BP94-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BP94" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { 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"uniprot_ac": "E1BP97", "uniprot_id": "E1BP97_BOVIN", "mass": { "chemical_mass": 66938.0, "monoisotopic_mass": 66938.0 }, "refseq": { "ac": "NP_001192777", "name": "protein disulfide-isomerase-like protein of the testis precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192777" }, "gene_names": [ { "name": "PDILT", "type": "recommended", "evidence": [ { "id": "E1BP97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP97" } ] }, { "name": "PDILT", "type": "synonym", "evidence": [ { "id": "NP_001192777", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192777" } ] } ], "protein_names": [ { "name": "Protein disulfide-isomerase-like protein of the testis", "type": "recommended", "evidence": [ { "id": "E1BP97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP97/entry#names_and_taxonomy" } ] }, { "name": "protein disulfide-isomerase-like protein of the testis precursor", "type": "synonym", "evidence": [ { "id": "NP_001192777", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192777" } ] } ], "function": [ { "annotation": "Probable redox-inactive chaperone involved in spermatogenesis.", "evidence": [ { "database": "UniProtKB", "id": "E1BP97", "url": "https://www.uniprot.org/uniprotkb/E1BP97#function" }, { "database": "UniProtKB", "id": "ARBA00056306", "url": "https://www.uniprot.org/uniprotkb/ARBA00056306#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BP97", "url": "https://www.uniprot.org/uniprotkb/E1BP97" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PDILT", "url": "https://www.uniprot.org/uniprotkb/E1BP97", "locus": { "chromosome": "25", "start_pos": 18032877, "end_pos": 18077429, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016434", "url": "https://www.ensembl.org/id/ENSBTAG00000016434" } ] } } ], "crossref": [ { "id": "E1BP97", "url": "https://alphafold.ebi.ac.uk/entry/E1BP97", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016434", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016434", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02961", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02961", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd02981", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02981", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd02982", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02982", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd02995", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02995", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518716", "url": "https://www.ncbi.nlm.nih.gov/gene/518716", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518716", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518716", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "APWSKKC", "url": "https://omabrowser.org/oma/group/APWSKKC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BP97", "url": "https://www.orthodb.org/?gene=E1BP97", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18929", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18929", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18929:SF58", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18929:SF58", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00085", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00085", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13848", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13848", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192777", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BP97", "url": "https://www.uniprot.org/uniprotkb/E1BP97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BP97-1", "url": "https://www.uniprot.org/uniprotkb/E1BP97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELLCMSLLLVASCVGTVQGSPEMNGKKESINMSQPLHILVEENLMVLTPAGLTQMLNETRFLMVLFHNPSSKQSRSLAEELGKAVEIMGKGKNGIGFGKVDVTVEKELQKEFDVKKAPELKLFFEGNRSQPISCEGVVESTALVVWLRRQISQKAFLFSNSNEIAEFVNSRPLVIIGFFQDLEEEVAELFYDMIKDFPELTFGAISIRHAIGRYHVTLDSVIVFKKGRIVNRQELINDNVNKQILNKLIKEQLTDLVIEYNTESRDLIYELNILNHMLLFVSKSSESFRIIMQHYKLASKIFQNKILFILVDTDVPRNRRVFKYFQIREVDVPCIQIINLSSDARYKMPFEEITYENLRNFGQSFLNRKAKKHLSSEEIPNYWDQGLVKQLVGKNFNVVVFDKERDVFVMFYAPWSQKCMVLFPVLEELGRKYQNHSTVTIAKIDITANDIELTYQDRYPFFRLFPTDSQKAVLYNGEHTLKGFSDFLESQIKIQIEDEDELLSVEQSEETEKKVLAEEKEEHFMKKELPEQNLPELENVTKLEGPTEQKEKAEEEKVAEPKEPPTQAEKPRMKEEL", "length": 578, "header": "tr|E1BP97-1|E1BP97_BOVIN Isoform 1 of Protein disulfide-isomerase-like protein of the testis OS=Bos taurus OX=9913 GN=PDILT PE=3 SV=1 CANONICAL=E1BP97-1" }, "isoforms": [ { "isoform_ac": "E1BP97-1", "url": "https://www.uniprot.org/uniprotkb/E1BP97/entry", "sequence": { "sequence": "MELLCMSLLLVASCVGTVQGSPEMNGKKESINMSQPLHILVEENLMVLTPAGLTQMLNETRFLMVLFHNPSSKQSRSLAEELGKAVEIMGKGKNGIGFGKVDVTVEKELQKEFDVKKAPELKLFFEGNRSQPISCEGVVESTALVVWLRRQISQKAFLFSNSNEIAEFVNSRPLVIIGFFQDLEEEVAELFYDMIKDFPELTFGAISIRHAIGRYHVTLDSVIVFKKGRIVNRQELINDNVNKQILNKLIKEQLTDLVIEYNTESRDLIYELNILNHMLLFVSKSSESFRIIMQHYKLASKIFQNKILFILVDTDVPRNRRVFKYFQIREVDVPCIQIINLSSDARYKMPFEEITYENLRNFGQSFLNRKAKKHLSSEEIPNYWDQGLVKQLVGKNFNVVVFDKERDVFVMFYAPWSQKCMVLFPVLEELGRKYQNHSTVTIAKIDITANDIELTYQDRYPFFRLFPTDSQKAVLYNGEHTLKGFSDFLESQIKIQIEDEDELLSVEQSEETEKKVLAEEKEEHFMKKELPEQNLPELENVTKLEGPTEQKEKAEEEKVAEPKEPPTQAEKPRMKEEL", "length": 578, "header": "tr|E1BP97-1|E1BP97_BOVIN Isoform 1 of Protein disulfide-isomerase-like protein of the testis OS=Bos taurus OX=9913 GN=PDILT PE=3 SV=1 CANONICAL=E1BP97-1" }, "locus": { "chromosome": "25", "start_pos": 18077429, "end_pos": 18032880, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021853.5", "url": "https://www.ensembl.org/id/ENSBTAT00000021853.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021853.3", "url": "https://www.ensembl.org/id/ENSBTAP00000021853.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518716", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518716", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B766-1", "protein_name": "Protein disulfide-isomerase-like protein of the testis", "gene_name": "PDILT", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALLRMFLLLVASCVTTVQGSQERDIKEDRINTSQPLYIPVEKNLMVLTPAGLTQMLNETRFLMVLFHNPSSKKSRDLADELGKAVEIMGTGKNGIGFGKVDITIEKELQEEFDIKEAPELKLFFEGNRLEPISCKGVVESTALVVWLRRQISQKAFLFNNTGDILEFVNSRPLVIMGFFQDLEEDLAELFYDTIKDFPELTFGVILIKNAIGNFRVTLDSVLVFKKGRIVNRQELINDNTNKQVLNQVIKQHLTDFVIEYNAETKDLIYELQVLNHMLLFVSKSSRSSGMIMQHYKLAAKKFQNKILFILVDADEPRNRRVFEYFRITEVDIPSVQILNLSSDARYKMPFEEITYENLKKFGTALKKSKKKKKKSSEEIPRYWDQGPIKQLVGKNFNVIVFDKERDVFVMFYAPWCPKCRALFPVLEELGLKYQNHSTVTIAKIDITANDVQLMQPDRYPFFRLFPTNSQQAVPYKGEHTLKGFSDFLESQINIRIEDEDELLSAEQSEATEEKVLTEGKEVPFIKKELLEQKLPELENVTRLEEPARQKEMAEEEEKVAEPKRPPRREKSPKVKEEL", "length": 579 }, "evidence": [ { "id": "E1BP97", "url": "https://omabrowser.org/oma/group/E1BP97/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5XI02-1", "protein_name": "Protein disulfide-isomerase-like protein of the testis", "gene_name": "Pdilt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELLWTPLLLLAACLSEVLGSPEMDTGINISQPLHILEDHNLMVLTPAGLTQTLNETRFLMVIFHNPTLKQSRKLAKELGKAAEIFGKGKNGLGFGKVDITMETELKQEFDITHAPELKLFYEGNRLEPISCKDVVESTALVVWLRRQISKKALLFNNSNEVADFVKSRPLVIVGFFQDLEEEVAELFYDTIKDFPELTFGAIQIKNSFGRFHVILDSVLVFKKGRVVKRQELINDSTNKDYLNQVIKQQLTGFVIEFNPENKDLIYEMNILNHMLLFISKNSEPYSTIIRHYRQISKEFQNKILFVLVNSDEPKNKRIFEYFQISRVNVPSVQILNLSSDARYKMPTDNITFESLKKFCNSFLSRTAKKHKSSEEIPKYWDQEPVKKLVGKNFNVVVFDKEKDVFVMFYAPWSEKCRVLLPLLEELGIKYQNHSTVIIAKIDITANDIQLANPEQYPFFRLFPTDSQEAVMYKGEHTMKGFCDFLESHVKVRIEEDDELLYIEQNEVAEEEVLAEPEMQHIDKLPEKPPLKVEDTSKQDRPAKESPALGSISQPEELERRKETAEKEKKVAQPKEQPKPERKLDIKEEL", "length": 590 }, "evidence": [ { "id": "E1BP97", "url": "https://omabrowser.org/oma/group/E1BP97/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N807-1", "protein_name": "Protein disulfide-isomerase-like protein of the testis", "gene_name": "PDILT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDLLWMPLLLVAACVSAVHSSPEVNAGVSSIHITKPVHILEERSLLVLTPAGLTQMLNQTRFLMVLFHNPSSKQSRNLAEELGKAVEIMGKGKNGIGFGKVDITIEKELQQEFGITKAPELKLFFEGNRSEPISCKGVVESAALVVWLRRQISQKAFLFNSSEQVAEFVISRPLVIVGFFQDLEEEVAELFYDVIKDFPELTFGVITIGNVIGRFHVTLDSVLVFKKGKIVNRQKLINDSTNKQELNRVIKQHLTDFVIEYNTENKDLISELHIMSHMLLFVSKSSESYGIIIQHYKLASKEFQNKILFILVDADEPRNGRVFKYFRVTEVDIPSVQILNLSSDARYKMPSDDITYESLKKFGRSFLSKNATKHQSSEEIPKYWDQGLVKQLVGKNFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQNHSTIIIAKIDVTANDIQLMYLDRYPFFRLFPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIEDEDELLSVEQNEVIEEEVLAEEKEVPMMRKGLPEQQSPELENMTKYVSKLEEPAGKKKTSEEVVVVVAKPKGPPVQKKKPKVKEEL", "length": 584 }, "evidence": [ { "id": "E1BP97", "url": "https://omabrowser.org/oma/group/E1BP97/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DAN1-1", "protein_name": "Protein disulfide-isomerase-like protein of the testis", "gene_name": "Pdilt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELLWTPLLLVAACLSEVLGSPEIDTGINISQPLHILEDHNLMVLTPAGLTQTLNETRFLMVIFHNPSLKQSRKLAKELGKAAEIFGKGKNGLGFGKVDITKETELQQEFDITHAPELKLFFEGNRLKPISCKDVVESTALVVWLRRQISKKALLFNNSDEVADFVKSRPLVIVGFFQDLEEEVAELFYDTIKDFPELTFGAIQIKNSFGRFHVILDSVLVFKKGKIVKRQELINDSTNKDHLNQVIKQQLTGFVIELNPENKDLIYELNILNHMLLFISKSSEPYSTISRHYRQIAKEFQNKILFVLVNADEPKNKRIFEYFQISRVNVPSVQILNLSSDGRYKMPTDDINFESLKKFCNSFLSKTAKKHKASEEIPKYWDQGPVKKLVGKNFNVVVLDKEKDVFVMFYAPWSEKCRVLLPLLEELGIKYQNHSTVIIAKIDITANDIQLANPEQYPFFRLFPTDSQEAVMYKGEHTMKGFCDFLESHVKVRIEEEDELLYIEQNEEEEVLAEPEIQLIEKLPENPLLKIEDTSKQDRPVKESPVLDSIRKPEEPERRKETAEREAAAAQPKEQPKPERKLEVKEEL", "length": 588 }, "evidence": [ { "id": "E1BP97", "url": "https://omabrowser.org/oma/group/E1BP97/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1BP97", "url": "https://www.uniprot.org/uniprotkb/E1BP97" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "E1BP97", "url": "https://www.uniprot.org/uniprotkb/E1BP97" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "E1BP97", "url": "https://www.uniprot.org/uniprotkb/E1BP97" } ], "pmid": "" }, { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "E1BP97", "url": "https://www.uniprot.org/uniprotkb/E1BP97" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein disulfide isomerase activity", "id": "GO:0003756", "url": 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12284", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12284", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003587468", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587468", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BPB2", "url": "https://www.uniprot.org/uniprotkb/E1BPB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPB2-1", "url": "https://www.uniprot.org/uniprotkb/E1BPB2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPSNYTTLDGAKEIEGLLGAGGSRNLVTHSPLTSHPTSAPTLMPAVNYAPLDLPGSAEPPKQCHPCPGVPQGASPAPVPYGYFGGGYYSCRVSRSSLKPCAQAATLAAYPAETPTSGEEYPSRPTEFAFYPGYPGPYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQPWALTGGWNSQMCCQGEQNPPGPFWKAAFADSSSQHPPEGCTFRRGRKKRIPYSKGQLRELEREYSANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKTSAPP", "length": 285, "header": "tr|E1BPB2-1|E1BPB2_BOVIN Isoform 1 of Homeobox B13 OS=Bos taurus OX=9913 GN=HOXB13 PE=3 SV=2 CANONICAL=E1BPB2-1" }, "isoforms": [ { "isoform_ac": "E1BPB2-1", "url": "https://www.uniprot.org/uniprotkb/E1BPB2/entry", "sequence": { "sequence": "MEPSNYTTLDGAKEIEGLLGAGGSRNLVTHSPLTSHPTSAPTLMPAVNYAPLDLPGSAEPPKQCHPCPGVPQGASPAPVPYGYFGGGYYSCRVSRSSLKPCAQAATLAAYPAETPTSGEEYPSRPTEFAFYPGYPGPYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQPWALTGGWNSQMCCQGEQNPPGPFWKAAFADSSSQHPPEGCTFRRGRKKRIPYSKGQLRELEREYSANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKTSAPP", "length": 285, "header": "tr|E1BPB2-1|E1BPB2_BOVIN Isoform 1 of Homeobox B13 OS=Bos taurus OX=9913 GN=HOXB13 PE=3 SV=2 CANONICAL=E1BPB2-1" }, "locus": { "chromosome": "19", "start_pos": 37794033, "end_pos": 37792302, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019523.7", "url": "https://www.ensembl.org/id/ENSBTAT00000019523.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019523.5", "url": "https://www.ensembl.org/id/ENSBTAP00000019523.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 116, "start_aa": "Thr", "end_pos": 116, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr116", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539688", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539688", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UR05-1", "protein_name": "Homeobox B13", "gene_name": "HOXB13", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPGNYATLDGAKEIEGLLGAGGSRNLVAHSPLTSHPAAAPTLMPAVNYAPLDLPGSAEPPKQCHPCSGVPQGASPAPVPYGYFGGGYYSCRVSRSSLKPCAQGATLAAYPAETPTAGEEYPSRPTEFAFYPGYPGPYQPMASYLDVSVVQTLGTPAEPRHDSLLPVDSYQPWALTGGWNSQVCCQGEQNPSGSFWKAAFADSSAQHPPEGCAFRRGRKKRIPYSKGQLRELEREYSANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKTSATP", "length": 285 }, "evidence": [ { "id": "E1BPB2", "url": "https://omabrowser.org/oma/group/E1BPB2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1AAB7-1", "protein_name": "Homeobox B13", "gene_name": "HOXB13", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQPPGLEGLLAAGGFAGGQGRVLPPPPAIGCPSPPPGMNPGYPTEEAAKPCLTAPPGPAAPPGPTASAPLPYGYLGGGYYSCRVARSALKAGPAQGPFPPEKYLDPPAGSEDFQSRPAELAFYPGYGAPYQPVAGYLDVSVVPGLGGPGEPRHEALLPVDGYHQPWALGGSWSGQMCCPKEQGQAGYLLKSAFADAAAPLPPDGCAFRRGRKKRVPYSKGQLKELEKEYASSKFITRDKRRKISAATNLTERQITIWFQNRRVKEKKVVAKIKSSSGAQ", "length": 279 }, "evidence": [ { "id": "E1BPB2", "url": "https://omabrowser.org/oma/group/E1BPB2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZWL5-1", "protein_name": "Homeo box B13", "gene_name": "Hoxb13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEPGNYATLDGAKDIEGLLGAGGGRNLVAHSSPLASHPAAPTLMPTVNYAPLDLPGSAEPPKQCHPCPGVPQGASPAPVPYGYFGGGYYSCRVSRSSLKPCAQTATLATYPSETPAPGEEYPSRPTEFAFYPGYPGPYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQPWALAGGWNSQMCCQGEQNPPGPFWKAAFAEPSVQHPPPDGCAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKTSTTP", "length": 286 }, "evidence": [ { "id": "E1BPB2", "url": "https://omabrowser.org/oma/group/E1BPB2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H5S1-1", "protein_name": "Homeobox protein Hox-B13", "gene_name": "Hoxb13", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEHGNYATLDGAKDIEGLLGAGGGRNLVAHSPLASHSATPTLMPTVNYAPLDLPGSAEPPKQCHPCPGVPQGASPAPVPYGYFGGGYYSCRVSRSSLKPCAQTATLATYPSETPAPGEEYPGRPTEFAFYPGYPGPYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQPWALASGWNSQMCCQGEQNPPGPFWKAAFAEPSTQHPPDGCAFRRGRKKRIPYSKGQLRELEREYATNKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKTSATP", "length": 284 }, "evidence": [ { "id": "E1BPB2", "url": "https://omabrowser.org/oma/group/E1BPB2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P70321-1", "protein_name": "Homeobox protein Hox-B13", "gene_name": "Hoxb13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPGNYATLDGAKDIEGLLGAGGGRNLVSHSSPLASHPAAPTLMPTVNYAPLDLPGSAEPPKQCHPCPGVPQGASPAPVPYGYFGGGYYSCRVSRSSLKPCAQTAALATYPSETPAPGEEYPSRPTEFAFYPGYPGPYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQPWALAGGWNSQMCCQGEQNPPGPFWKAAFAEPSVQHPPPDGCAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKTSTTP", "length": 286 }, "evidence": [ { "id": "E1BPB2", "url": "https://omabrowser.org/oma/group/E1BPB2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92826-1", "protein_name": "Homeobox protein Hox-B13", "gene_name": "HOXB13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPGNYATLDGAKDIEGLLGAGGGRNLVAHSPLTSHPAAPTLMPAVNYAPLDLPGSAEPPKQCHPCPGVPQGTSPAPVPYGYFGGGYYSCRVSRSSLKPCAQAATLAAYPAETPTAGEEYPSRPTEFAFYPGYPGTYQPMASYLDVSVVQTLGAPGEPRHDSLLPVDSYQSWALAGGWNSQMCCQGEQNPPGPFWKAAFADSSGQHPPDACAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKVLAKVKNSATP", "length": 284 }, "evidence": [ { "id": "E1BPB2", "url": "https://omabrowser.org/oma/group/E1BPB2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "E1BPB2", "url": "https://www.uniprot.org/uniprotkb/E1BPB2" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BPB2", "url": "https://www.uniprot.org/uniprotkb/E1BPB2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BPB2", "url": "https://www.uniprot.org/uniprotkb/E1BPB2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BPB2", "url": "https://www.uniprot.org/uniprotkb/E1BPB2" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "E1BPB2", "url": "https://www.uniprot.org/uniprotkb/E1BPB2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "E1BPB2", "url": "https://www.uniprot.org/uniprotkb/E1BPB2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BPB2", "url": "https://www.uniprot.org/uniprotkb/E1BPB2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "E1BPB2", "url": "https://www.uniprot.org/uniprotkb/E1BPB2" } ], "pmid": "" }, { "name": "methyl-CpG binding", "id": "GO:0008327", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008327", "evidence": [ { "database": "UniProtKB", "id": "E1BPB2", "url": "https://www.uniprot.org/uniprotkb/E1BPB2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPB2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 285, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPB2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPB2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB2" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 215, "end_pos": 275, "start_aa": "Arg", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 116 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPC1-1", "uniprot_ac": "E1BPC1", "uniprot_id": "E1BPC1_BOVIN", "mass": { "chemical_mass": 69637.0, "monoisotopic_mass": 69637.0 }, "refseq": { "ac": "XP_010815164", "name": "centrosomal protein of 72 kDa isoform X7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010815164" }, "gene_names": [ { "name": "CEP72", "type": "recommended", "evidence": [ { "id": "E1BPC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPC1" } ] }, { "name": "CEP72", "type": "synonym", "evidence": [ { "id": "XP_010815164", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010815164" } ] } ], "protein_names": [ { "name": "Centrosomal protein of 72 kDa", "type": "recommended", "evidence": [ { "id": "E1BPC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPC1/entry#names_and_taxonomy" } ] }, { "name": "centrosomal protein of 72 kDa isoform X7", "type": "synonym", "evidence": [ { "id": "XP_010815164", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010815164" } ] } ], "function": [ { "annotation": "Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). Involved in centriole duplication. 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"https://www.ensembl.org/id/ENSBTAG00000011405" } ] } } ], "crossref": [ { "id": "E1BPC1", "url": "https://alphafold.ebi.ac.uk/entry/E1BPC1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011405", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011405", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617312", "url": "https://www.ncbi.nlm.nih.gov/gene/617312", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BPC1", "url": "https://www.orthodb.org/?gene=E1BPC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23311", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23311", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23311:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23311:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14580", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14580", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010815164", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010815164", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BPC1", "url": "https://www.uniprot.org/uniprotkb/E1BPC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPC1-1", "url": "https://www.uniprot.org/uniprotkb/E1BPC1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPGGRVVLCEEKIREKSGLAPHCDLAELQSLSIPGTYQEKITHLGNSLMNLTSLKSLDLSRNSLVSLEGIECLTALESLNLYYNRISSLAEVFRLHSLAGLLDVDLRLNPVVKSEPDYRLFMVHMLPGLQQLDDRPVRESERRASRLHFGSEESLDSEQSFPSVFREERPHHSRVKCTDSSAKKCLVMDADDEAVLSLIAECEWDLSNPPGGMSSSQKESEASLQTSQAESRHRLSPQSVQHQCGDSLWKGPERGRSSSRAGCVEPRLQDQRCGELPPQRFTPDSTETEDSGASSQKSSVSTQKMLNPLPAPEKYRKRRMPGGRFQAPADEACLSCLEGSLSVSRRSSSEGWGQATSSLSATPGPEQPRPPSASEACPKLHSTALPGKKATLEALLLEALLDLVDRHWSGRRSLHSSEAFLAQARHILSSVQEFTTTQDTSTTVNEEISSLTLENKSLHSRLTELQQQYGVKMTEVVLELSDTRKEMDYLRQHLDRSLEESSSLKSLLLSMKKDVRTADAPSALNLQISGLQASMKRLSGELVELRQHLEHYDKIQELTQMLQESHSSLVRTNERLLQELDQVRAQHQAEVEQLHWSYKELKKTLARFPGSPRDARPASPPRAL", "length": 625, "header": "tr|E1BPC1-1|E1BPC1_BOVIN Isoform 1 of Centrosomal protein of 72 kDa OS=Bos taurus OX=9913 GN=CEP72 PE=3 SV=2 CANONICAL=E1BPC1-1" }, "isoforms": [ { "isoform_ac": "E1BPC1-1", "url": "https://www.uniprot.org/uniprotkb/E1BPC1/entry", "sequence": { "sequence": "MAPGGRVVLCEEKIREKSGLAPHCDLAELQSLSIPGTYQEKITHLGNSLMNLTSLKSLDLSRNSLVSLEGIECLTALESLNLYYNRISSLAEVFRLHSLAGLLDVDLRLNPVVKSEPDYRLFMVHMLPGLQQLDDRPVRESERRASRLHFGSEESLDSEQSFPSVFREERPHHSRVKCTDSSAKKCLVMDADDEAVLSLIAECEWDLSNPPGGMSSSQKESEASLQTSQAESRHRLSPQSVQHQCGDSLWKGPERGRSSSRAGCVEPRLQDQRCGELPPQRFTPDSTETEDSGASSQKSSVSTQKMLNPLPAPEKYRKRRMPGGRFQAPADEACLSCLEGSLSVSRRSSSEGWGQATSSLSATPGPEQPRPPSASEACPKLHSTALPGKKATLEALLLEALLDLVDRHWSGRRSLHSSEAFLAQARHILSSVQEFTTTQDTSTTVNEEISSLTLENKSLHSRLTELQQQYGVKMTEVVLELSDTRKEMDYLRQHLDRSLEESSSLKSLLLSMKKDVRTADAPSALNLQISGLQASMKRLSGELVELRQHLEHYDKIQELTQMLQESHSSLVRTNERLLQELDQVRAQHQAEVEQLHWSYKELKKTLARFPGSPRDARPASPPRAL", "length": 625, "header": "tr|E1BPC1-1|E1BPC1_BOVIN Isoform 1 of Centrosomal protein of 72 kDa OS=Bos taurus OX=9913 GN=CEP72 PE=3 SV=2 CANONICAL=E1BPC1-1" }, "locus": { "chromosome": "20", "start_pos": 71529096, "end_pos": 71492112, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015158.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015158.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015158.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015158.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 363, "start_aa": "Thr", "end_pos": 363, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr363", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { 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[ "Protein Classification" ] }, { "id": "PF00130", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00130", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17820", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17820", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26547", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26547", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179439", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BPC2", "url": "https://www.uniprot.org/uniprotkb/E1BPC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPC2-1", "url": "https://www.uniprot.org/uniprotkb/E1BPC2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLLLMILASAVLGSFLTLLTQFLLLYRKQPEPPPDEAARAADGFRYIKPVPDLPLREYLYGGGGGAEEPSGGPPEGGATPAPETPAPPTRETCYFLNAIILFLFRELRDTALARRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLLRPVAPSATGEPDGPEGEALPPATTPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRFVLTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPLPQLTSFIVNQLKKIIKRKHTLPSYKIRYKPFFPFQTLQGFEDDDEELIHIQQWALTEGRLKVTLLECSRLLIFGSYDTEANIHCTLELSTGVWEEKQRSSIKTVELIKGNLQSVGLTLRLVQSTDGYAGHVIIETVAPNSPAAIANLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVLVYYERPVGQSNQGTVLQDNFGQLEENFLSGSCQPNFEEEATGLAVDAENRDLDSEFEDLASDVRAQTEAREEAQSLSHSPKRTPTTLSVKPLGTISPVLNRKLVVGSYPPPPKLPSKEGNKPLALKSSEVTEPAQVSKPTQGPSFKPPVPPRPQVKVPLPSSDDPTQAEPDISVEKPEKVLPPPPADKPAEKQVKNLDHIEEAAAAKQFLAKQEVAKDLTSESACPPKDSSDDHQTWESSEIPYRKKLGKWTRTKASCFFDIEACHRYLNIALWCRDPFKLGGLICLGHVSLKLEEVALGCLATSNMEYLSKFRLEAPSPKAMVTRTALRNLSMQKGFNDKFCYGDITVHFKYLKEGEPDHVVTNLEKEKELHLVEEVSALPKEEHFVGQMGLTENKHSFQDTQFQNPTWCDYCKKKVWTKAASQCMFCAYVCHKKCQEKCLAETPLCGATDQRIDRALKNLRLEGQETLLGLPPRVDAEAGKSVNRTTGLTRHIINTSSRLLNLRPVSKTRLSEPGTDLVEPSPKHTPNTSDNEGSDTEVCGSNSPSKRGNSAGIKLVRKEGGLDDSVFIAVKEIGRDLYRGLPTEERIQKLEFMLDKLQNEIDQELEHNNSLVRDEKETTDTRKKSLLSASLAKSGERLQALTLLMIHYRAGIEDIESLESLSLDQHSKKISKYTDDTEEDLDSEITQLIDSQPFSSISDDLFGPSESV", "length": 1154, "header": "tr|E1BPC2-1|E1BPC2_BOVIN Isoform 1 of PDZ domain-containing protein 8 OS=Bos taurus OX=9913 GN=PDZD8 PE=4 SV=2 CANONICAL=E1BPC2-1" }, "isoforms": [ { "isoform_ac": "E1BPC2-1", "url": "https://www.uniprot.org/uniprotkb/E1BPC2/entry", "sequence": { "sequence": "MGLLLMILASAVLGSFLTLLTQFLLLYRKQPEPPPDEAARAADGFRYIKPVPDLPLREYLYGGGGGAEEPSGGPPEGGATPAPETPAPPTRETCYFLNAIILFLFRELRDTALARRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLLRPVAPSATGEPDGPEGEALPPATTPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRFVLTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPLPQLTSFIVNQLKKIIKRKHTLPSYKIRYKPFFPFQTLQGFEDDDEELIHIQQWALTEGRLKVTLLECSRLLIFGSYDTEANIHCTLELSTGVWEEKQRSSIKTVELIKGNLQSVGLTLRLVQSTDGYAGHVIIETVAPNSPAAIANLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVLVYYERPVGQSNQGTVLQDNFGQLEENFLSGSCQPNFEEEATGLAVDAENRDLDSEFEDLASDVRAQTEAREEAQSLSHSPKRTPTTLSVKPLGTISPVLNRKLVVGSYPPPPKLPSKEGNKPLALKSSEVTEPAQVSKPTQGPSFKPPVPPRPQVKVPLPSSDDPTQAEPDISVEKPEKVLPPPPADKPAEKQVKNLDHIEEAAAAKQFLAKQEVAKDLTSESACPPKDSSDDHQTWESSEIPYRKKLGKWTRTKASCFFDIEACHRYLNIALWCRDPFKLGGLICLGHVSLKLEEVALGCLATSNMEYLSKFRLEAPSPKAMVTRTALRNLSMQKGFNDKFCYGDITVHFKYLKEGEPDHVVTNLEKEKELHLVEEVSALPKEEHFVGQMGLTENKHSFQDTQFQNPTWCDYCKKKVWTKAASQCMFCAYVCHKKCQEKCLAETPLCGATDQRIDRALKNLRLEGQETLLGLPPRVDAEAGKSVNRTTGLTRHIINTSSRLLNLRPVSKTRLSEPGTDLVEPSPKHTPNTSDNEGSDTEVCGSNSPSKRGNSAGIKLVRKEGGLDDSVFIAVKEIGRDLYRGLPTEERIQKLEFMLDKLQNEIDQELEHNNSLVRDEKETTDTRKKSLLSASLAKSGERLQALTLLMIHYRAGIEDIESLESLSLDQHSKKISKYTDDTEEDLDSEITQLIDSQPFSSISDDLFGPSESV", "length": 1154, "header": "tr|E1BPC2-1|E1BPC2_BOVIN Isoform 1 of PDZ domain-containing protein 8 OS=Bos taurus OX=9913 GN=PDZD8 PE=4 SV=2 CANONICAL=E1BPC2-1" }, "locus": { "chromosome": "26", "start_pos": 37687376, "end_pos": 37607543, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015152.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015152.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015152.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015152.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519573", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519573", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZPH0-1", "protein_name": "PDZ domain containing 8", "gene_name": "PDZD8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLPVYTILLSALAGCLLTLLLQLLLLYRKAPQPPGGIGAEDGLVYARVAAGRSLKDYLHGTEPVGGQAALEPAPATATASASAPAASAPSAGPEPGTKPAQQPEPGPEPSSSEETCHFLNAIFLFLFRELRDTALVRNWVTKKIKVEFEELLQTKMTGKVLEGLSLRDVYLGNVLPVFKAVRLIRPVVCSEEGCPEELGFEVDLEYNGGFHLAIDADLVFGKSAYLFVKLSRVMGKLKLVFTRLPFTHWYFSFMDDPLIVFEVKSQFEGRPMPQLTSIIVNQFKKVIKRKHTLPNYKIRYKPFFPFQVSSPDEYEDRDLYIQDLPLTEGRLKVTLIECTRLFIFGSYEKETNVHCTMELSSSVWEEKSRSSIKTAELVKGNLQSVGLTLRLVQSKEDDAGHVVIETVTPNSPAAAADLQRGDRLLAIGSVKITSTVQVLKLIRQAGDKVLVFYERPVGYNQHGSALQDGFGQLEDTAFLTQQEDDQVSVSADVDSRDFDSEFEDLACESPDQKEDMPTTPSPKRSVVILAAKPLGTISPILNRKLHLGNYQTTSKMQQKDGAKLATPRTSDSSDTSQLSGKQSQGSGTKPPVPPRPQIRPTLPTNETQNLLETGGVSSEKTEKPPPSSGNGDKCTEKVVKNNDQTEDPTLSKVATIPKQDALKDGISENARGHKDGGDDHRTWESPEIPYRVRQGRWPKARTSSCLFEVEGSHKYLNVALWCRDPFKAGGFICLGYASIKLEEIALDCIATSSMEYVRTFKLSAPTPKAAVTRTALRNLTTHKGFNEKFCYGDIALHFKYFKEGEVDDSNFLLEKEKECHLEEEVNVLQKEDTYLGQIVLTENKHNFQDTQFQNPTWCDYCKKKVWTKAASQCMLCAYVCHKKCQEKCLAETPFCVGAEKRHDRTAGGCRAEGQETSQAASVRVDSESKSVNRTAGLTRHIINTSTRLLNLRQVPKARLSEQGTEIVEPSPKHTPNTSDNESSDTEISGPSSPSKRASGSGIKLVRKEGGLDDSVFIAVKEIGRDLYRSLPTEERFQKLEFMLDKLQNEIDQELENNNSLVKEEKEATEARKKALISAALAKSGERLQALTLLMIHYRAGIEDIESLESMSSDRQSKRVTKDSEEASIAEEVDNEDIGLTEAPTLNIISDESVDPPQSVD", "length": 1160 }, "evidence": [ { "id": "E1BPC2", "url": "https://omabrowser.org/oma/group/E1BPC2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B9EJ80-1", "protein_name": "PDZ domain-containing protein 8", "gene_name": "Pdzd8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLLLLILASAVLGSFLTLLAQFLLLYRRQPEPRADEAARAGDGFRYLKPVPGLPLREYLYGGGAEELAACSSEAGASSTPTPDSPAPPTLETCYFLNATILFLFRELRDTALARRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGDTVPFIKTIRLVRPVVASGTGEPDDPDGDALPATCPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRFVLTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSIIVNQLKKIIKRKHTLPSYKIRFKPFFPYQALQGFEEDEELIHIQQWALTEGRLKVTLLECSRLFIFGSYDRETNVHCTLELSSGVWEEKQRSSIKTVELIKGNLQSVGLTLRLVQSTDGYAGHVIIETVAPNSPAAMADLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVLVYYQRPAGQSSQDSLGQLEESFLSSSCQAAYEEDAAGLSADTENRDLDSEFEDLASDVRVQTELKEETQPLSHSPKRTPTTLSIKPLGAISPVLNRKLISGIHPPPQKLPSKEGNKPSTLKTSETTEAAQVSKPQGPTFKPPVPPRPQGRVPLPPTDTSAQADPEAPEKPDKVLLPPPPADKPAEKQVKSVDQGEDVAAGKQSSAKQEGVKDLPSESSAPTKDSSDDPQMWESSEVLYRNKVGKWSRTRASCVFDIEACHRYLNIALWCRDPFKLGGLICLGHVSLKLEEVALGCLATSNMEYLTKFRLEPPTPKAMVTRTALRNLSMQKGFNDKFCFGDITIHFKYLKEGEPDHHIVPNVEKEKELHLVEEVSTLPKEEHFVGQMSLSENKHSFQDTQFQNPTWCDYCKKKVWTKAASQCMFCAYVCHKKCQEKCLAETPLCGATERRIDRTLKNLRLEGQDPLLGLPPRVEIEANKSVNKTTGLTRHIINTSSRLLNLRQVSKTRLSEPGTDLVEPSPKHTPNTSDNEGSDTEVCGSNSPSKRGNSAGIKLMRKEGGLDDSVFIAVKEIGRDLYRGLPTEERIQKLEFMLDKLQNEIDQELEHNNSLVREEKETNDTRKKSVLSAALAKSGERLQALTLLMIHYRAGIEDIETLENLSLDQHSKKMNKYADDTEEDLDSEISQLIDSQPFSNISDDLFGPSESV", "length": 1147 }, "evidence": [ { "id": "E1BPC2", "url": "https://omabrowser.org/oma/group/E1BPC2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZXY2-1", "protein_name": "PDZ domain-containing protein 8", "gene_name": "Pdzd8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLLLMILASAVLGSFLTLLTQFLLLYRRQPEPRADEAARAGDGFRYLKPVPGLPLREYLYGGGAEEPAAGSSEAGASTTPTPDSPAPPTLETCYFLNATILFLFRELRDTALARRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGDTVPYIKTIRLVRPVVASGTGEPDEPDGDALPATCPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRFVLTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSIIVNQLKKIIKRKHTLPSYKIRFKPFFPYQALQGFEEDEDLIHIQQWALTEGRLKVTLLECSRLLIFGSYEREANVHCTLELSSGVWEEKQRSSIKTVELIKGNLQSVGLTLRLVQSTDGYAGHVIIETVAPNSPAAIADLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVLVYYQRPVGQSNQGAMLQDSLGQLEENFLSSSCQPGYEEEAAGLPVDSETRDLDSEFEDLAGDVRVQTELKEETQPLSHSPKRTPTTLSIKPLGAISPVLNRKLISGIHPPPQKLPSKEGNKPSTLKTSEATEAAQVSKPQVPTFKPPVPPRPQGRVPLPPTDTSAQADPETTEKPEKVLLPPPPADKPAEKQVKSVDHGEDVAAGKQPPAKQEVVKDAPSESSAPTKDPSDDHQMWESSEVLYRNKVGKWSRARASCVFDIEACHRYLNIALWCRDPFKLGGLICLGHASLKLEEVALGCLATSNMEYLSKFRLEPPAPKAMVTRTALRNLSMQKGFNDKFCFGDITIHFKYLKEGEPDHQIVPSVEKERELHVVEEVSTLPKEDHFVGQMSLSENKHSFQDTQFQNPTWCDYCKKKVWTKAASQCMFCAYVCHKKCQEKCLAETPLCGATERRVDRTLKSLRLEGQDPLLGLPPRVEMEANKSVNKTTGLTRHIINTSSRLLNLRQVSKTRLAEPGTDLVEPSPKHTPNTSDNEGSDTEVCGPNSPSKRGNSAGIKLTRKEGGLDDSVFIAVKEIGRDLYRGLPTEERIQKLEFMLDKLQNEIDQELEHNNSLVREEKETNDTRKKSVLSASLAKSGERLQALTLLMIHYKAGIEDIETLENLSLDQHSKKMNKYTEDTEEDLDSEISQLIDSQPFSNISDDLFGPSESV", "length": 1152 }, "evidence": [ { "id": "E1BPC2", "url": "https://omabrowser.org/oma/group/E1BPC2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S4R6-1", "protein_name": "PDZ domain-containing protein 8", "gene_name": "PDZD8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGLLLMILASAVLGSFLTLLTQFLLLYRKQPLPPPDEAARAAEGFRYIKPVPGLALREYLYGGGGAEEPAGGSPEGGATPTPETPAPPTRETCYFLNATILFLFRELRDTALARRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLLRPVVPSATGEPDGPEGEALPATSPEELAFEAEVEYDGGFHLAIDVDLVFGKSAYLFVKLSRVEGRLRFVLTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSIIVNQLKKIIKRKHTLPSYKIRFKPFFPFQTLKGFEEEEEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANIHCTLELSSGVWEEKQRSSIKTVELIKGNLQSVGLTLRLVQSTDGYAGHVIIETVAPNSPAAVADLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVLVYYERPVGQSNQSVVLQDNFGQLEENFLSSSCQPTYEEETTGLAIDAENRDLDSEFEDLASDVRAQTEVKDEAQSLSHSPKRIPTTLSVKPLGTISPVLNRKLAVGGHPPPPKLPSKEGHKSLALKSSEITEPAQMSKPTQGSTFKPPVPPRPQVKIPLPSADTPNQAELDIPVEKPEKVTLPPPLTDKPAEKQVKNLDHVEEATAAKQFLAKQEVAKDLTSESSCPPKDSSDDPQTWESSEIPYRNKLGKWTRTRASCSFDIEACHRYLNIALWCRDPFKLGGLICLGHVSLKLEEVALGCLATSNMEYLSKFRLEAPSPKAMVTRTALRNLSVQKGFNDTFCFGDITVHFKYLKEGEPEHHVVTNLEKEKELHLVEEVSALTKEEHFVGQTGLTENKHSFQDTQFQNPTWCDYCKKKVWTKAASQCMFCAYVCHKKCQEKCLAETPLCGATDQRIDRALKNLRLEGQETLLGLPPRVDAEAGKSVNRTTGLTRHIINTSSRLLNLRQVSKTRLSEPGTDLVEPSPKHTPNTSDNEGSDTEVCGPNSPSKRGNNTGIKLVRKEGGLDDSVFIAVKEIGRDLYRGLPTEERIQKLEFMLDKLQNEIDQELEHNNSLVREEKETTDSRKKSILSAALAKSGERLQALTLLMIHYRAGIEDVESLESLSLDQHSKKISKYTDDTEEDLDNEITQLIDSQPFSSIPDDLFGPSESV", "length": 1154 }, "evidence": [ { "id": "E1BPC2", "url": "https://omabrowser.org/oma/group/E1BPC2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8NEN9-1", "protein_name": "PDZ domain-containing protein 8", "gene_name": "PDZD8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGLLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYLYGGGRDEEPSGAAPEGGATPTAAPETPAPPTRETCYFLNATILFLFRELRDTALTRRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGEALPAACPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSIIVNQLKKIIKRKHTLPNYKIRFKPFFPYQTLQGFEEDEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANVHCTLELSSSVWEEKQRSSIKTVELIKGNLQSVGLTLRLVQSTDGYAGHVIIETVAPNSPAAIADLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVLVYYERPVGQSNQGAVLQDNFGQLEENFLSSSCQSGYEEEAAGLTVDTESRELDSEFEDLASDVRAQNEFKDEAQSLSHSPKRVPTTLSIKPLGAISPVLNRKLAVGSHPLPPKIQSKDGNKPPPLKTSEITDPAQVSKPTQGSAFKPPVPPRPQAKVPLPSADAPNQAEPDVLVEKPEKVVPPPLVDKSAEKQAKNVDAIDDAAAPKQFLAKQEVAKDVTSETSCPTKDSSDDRQTWESSEILYRNKLGKWTRTRASCLFDIEACHRYLNIALWCRDPFKLGGLICLGHVSLKLEDVALGCLATSNTEYLSKLRLEAPSPKAIVTRTALRNLSMQKGFNDKFCYGDITIHFKYLKEGESDHHVVTNVEKEKEPHLVEEVSVLPKEEQFVGQMGLTENKHSFQDTQFQNPTWCDYCKKKVWTKAASQCMFCAYVCHKKCQEKCLAETSVCGATDRRIDRTLKNLRLEGQETLLGLPPRVDAEASKSVNKTTGLTRHIINTSSRLLNLRQVSKTRLSEPGTDLVEPSPKHTPNTSDNEGSDTEVCGPNSPSKRGNSTGIKLVRKEGGLDDSVFIAVKEIGRDLYRGLPTEERIQKLEFMLDKLQNEIDQELEHNNSLVREEKETTDTRKKSLLSAALAKSGERLQALTLLMIHYRAGIEDIETLESLSLDQHSKKISKYTDDTEEDLDNEISQLIDSQPFSSISDDLFGPSESV", "length": 1154 }, "evidence": [ { "id": "E1BPC2", "url": "https://omabrowser.org/oma/group/E1BPC2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VYR9-1", "protein_name": "PDZ domain-containing protein 8", "gene_name": "Pdzd8", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEIPISNILLLCLIFLLIGGVVMILLQYLIFIKFSNLPDESEEQKQANAKYTLPLNIKQTARNLKRLSNSGLGGGAGNGCENHQESLRRASALVSLNFVMQFLFHEFKNSNRVRKWFYRKLSIELDELISKTTTGKLLDKLTIKELELGDQFPDVKSLSVHNVELDKDEQRIENLDLLLDINYVGNFTTSIDADMVLGKKGSITLRVKQLSGMARLQFTRKPYTHWSISFLGDPELILDIESKYQGRQMQSNITNLISNQIRKAVRRKHTLPNYKLRYKPFFHWTAEEDASDCDIQPNGLLTVKLAELSRLMGYPGASETYCTITLAPVPFIEASQRDSRNVLISLDVFIHKAKNQQIGIVFKQSGSQVVRIESVLPNTPACKSNLLAGDVLVAIEGRPVTTIQQIAKVVKTLQATVFSLRIERIIPGIIRNDAILEDFEKYEDIGDLPSSYPCQPKLETDEAATADPTPKHLVVKPSLSGTPTNSPKKSNLIAKAIKKTMSRESGDKDRDKDKDKDKDKDKDKDKDKDKDKDKDKDKGKEEVEEPVNYFYQHSTIDCPFSPLIHMEDVCSFQLDNSSRFLNVCVFGKSAGESVLLGYNNVQIGQILVECSETSLNQCLKQISLNPASLQAVKTHPLSNQSGFNPNLCFGDILFGFSWMGNPNLTVGDVPIKSTSKSQSPARNPLAGDRVASEDQSQFLKLTSSMADSSTSGESSSGTTAAPRAHDFVRTHFHRATQCDFCGKKIWLKDAMQCQECSMCCHKKCIVKCQMATVCGPVDCTGSIPATSSTPSMASRPEFTITQADNPQIVDSSTGATPFDETSAASGGDQGQIQSPTASGLDVHRSSLTGMLAQGIKRQASNLDIPGIVSSLTGSGQQVNSKSLPPSPQHTPSRKSSIVEEATPALQQNPFESVTQHLEALPLDCPELSFEQVIVITEPIIRHTRNEDLMNLAKSTSKLLYAALPPDERVAKINELLTKLKVALDAETEGYTLMNDAEKATESSPWKSDRSDERVQALSIIMLYLCTGLQHAQGVVLQ", "length": 1037 }, "evidence": [ { "id": "E1BPC2", "url": "https://omabrowser.org/oma/group/E1BPC2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BPC2", "url": "https://www.uniprot.org/uniprotkb/E1BPC2" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1BPC2", "url": "https://www.uniprot.org/uniprotkb/E1BPC2" } ], "pmid": "" }, { "name": "mitochondria-associated endoplasmic reticulum membrane contact site", "id": "GO:0044233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044233", "evidence": [ { "database": "UniProtKB", "id": "E1BPC2", "url": "https://www.uniprot.org/uniprotkb/E1BPC2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "E1BPC2", "url": "https://www.uniprot.org/uniprotkb/E1BPC2" } ], "pmid": "" }, { "name": "mitochondrial calcium ion homeostasis", "id": "GO:0051560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051560", "evidence": [ { "database": "UniProtKB", "id": "E1BPC2", "url": "https://www.uniprot.org/uniprotkb/E1BPC2" } ], "pmid": "" }, { "name": "mitochondrion-endoplasmic reticulum membrane tethering", "id": "GO:1990456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990456", "evidence": [ { "database": "UniProtKB", "id": "E1BPC2", "url": "https://www.uniprot.org/uniprotkb/E1BPC2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BPC2", "url": "https://www.uniprot.org/uniprotkb/E1BPC2" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "E1BPC2", "url": "https://www.uniprot.org/uniprotkb/E1BPC2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1054, "end_pos": 1056, "annotation": "n_glycosylation_sequon" }, { "start_pos": 774, "end_pos": 776, "annotation": "n_glycosylation_sequon" }, { "start_pos": 929, "end_pos": 931, "annotation": "n_glycosylation_sequon" }, { "start_pos": 940, "end_pos": 942, "annotation": "n_glycosylation_sequon" }, { "start_pos": 973, "end_pos": 975, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPC2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1154, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPC2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPC2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPC2" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 367, "end_pos": 450, "start_aa": "Thr", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BPC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPC2" }, { "id": "PS50081", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50081" } ], "ann_type": "Domain_Extent_Annotation", 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"https://www.uniprot.org/uniprotkb/E1BPC9/entry#names_and_taxonomy" } ] }, { "name": "Axonal glycoprotein TAG-1", "type": "synonym", "evidence": [ { "id": "E1BPC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPC9/entry#names_and_taxonomy" } ] }, { "name": "Axonin-1", "type": "synonym", "evidence": [ { "id": "E1BPC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPC9/entry#names_and_taxonomy" } ] }, { "name": "Transient axonal glycoprotein 1", "type": "synonym", "evidence": [ { "id": "E1BPC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPC9/entry#names_and_taxonomy" } ] }, { "name": "contactin-2", "type": "synonym", "evidence": [ { "id": "XP_003587094", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587094" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, 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"https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04969", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05727", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05727", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05854", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05854", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100140960", "url": "https://www.ncbi.nlm.nih.gov/gene/100140960", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047102", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047102", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100140960", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140960", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MPDANPR", "url": "https://omabrowser.org/oma/group/MPDANPR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPC9", "url": "https://www.orthodb.org/?gene=E1BPC9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44170", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44170", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44170:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44170:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003587094", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587094", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPC9-1", "url": "https://www.uniprot.org/uniprotkb/E1BPC9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTPLGRKAHLLMLVAVALVSTPAWSSAWGSPATFGPVFEEQPLGLLFPEESTEEKVTLACRARASPPATYRWKMNGTEMKLEPGSRQQLVGGNLVIMNPSKAQDAGVYQCLASNPVGTVVSREAVLRFGFLQEFSKEERDPVKTHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWATAEPTLQIPSVGFEDEGTYECEAENTKGRDTVQGRIIVQAQPEWLRVISDREADIGSDLHWACAAAGKPRPAVRWLRNGEPLTSQARVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEVVIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNVSRSDEGKYTCFAENFMGKANSTGTLSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFVWTLDDFPIDFDKPGGHYQRASVKETVGDLTILNAQLRHGGKYTCTAQTVVDSASKEATVLVRGPPGAPGGVVVRDISDTSVQLSWSRGFDNHSPIAKYTLQARTLPSGKWKQVRTNPTNIEGNAETAQVLGLTPWMDYEFRVLASNILGTGEPSGPSSKIQTKEAAPSVAPSGLSGGGGAPGELTVTWTPMSREYQHGGGFGYLVSFRRQGGTSWQTARVPGADAQYFVYSNDSIRPYTPFEVKIRSYNRRGDGPESLVAVVYSAEEEPRVAPPKVWAKAVSSSEMNVSWEPVQQDMNGILLGYEIRYWKAGAKAAAAERVRTAGLDTSALVTGLHASTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPLGNESAVTGYKMLYQNDLHPTPTLHLTSKNWIEITVPEDIGHALVQIRTTGPGGDGVPAEVHIVRNGGTSMMVENSAVCPAPHPDAALTHSVAALILLGYLQL", "length": 1040, "header": "tr|E1BPC9-1|E1BPC9_BOVIN Isoform 1 of Contactin-2 OS=Bos taurus OX=9913 GN=CNTN2 PE=3 SV=3 CANONICAL=E1BPC9-1" }, "isoforms": [ { "isoform_ac": "E1BPC9-1", "url": "https://www.uniprot.org/uniprotkb/E1BPC9/entry", "sequence": { "sequence": "MGTPLGRKAHLLMLVAVALVSTPAWSSAWGSPATFGPVFEEQPLGLLFPEESTEEKVTLACRARASPPATYRWKMNGTEMKLEPGSRQQLVGGNLVIMNPSKAQDAGVYQCLASNPVGTVVSREAVLRFGFLQEFSKEERDPVKTHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWATAEPTLQIPSVGFEDEGTYECEAENTKGRDTVQGRIIVQAQPEWLRVISDREADIGSDLHWACAAAGKPRPAVRWLRNGEPLTSQARVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEVVIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNVSRSDEGKYTCFAENFMGKANSTGTLSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFVWTLDDFPIDFDKPGGHYQRASVKETVGDLTILNAQLRHGGKYTCTAQTVVDSASKEATVLVRGPPGAPGGVVVRDISDTSVQLSWSRGFDNHSPIAKYTLQARTLPSGKWKQVRTNPTNIEGNAETAQVLGLTPWMDYEFRVLASNILGTGEPSGPSSKIQTKEAAPSVAPSGLSGGGGAPGELTVTWTPMSREYQHGGGFGYLVSFRRQGGTSWQTARVPGADAQYFVYSNDSIRPYTPFEVKIRSYNRRGDGPESLVAVVYSAEEEPRVAPPKVWAKAVSSSEMNVSWEPVQQDMNGILLGYEIRYWKAGAKAAAAERVRTAGLDTSALVTGLHASTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPLGNESAVTGYKMLYQNDLHPTPTLHLTSKNWIEITVPEDIGHALVQIRTTGPGGDGVPAEVHIVRNGGTSMMVENSAVCPAPHPDAALTHSVAALILLGYLQL", "length": 1040, "header": "tr|E1BPC9-1|E1BPC9_BOVIN Isoform 1 of Contactin-2 OS=Bos taurus OX=9913 GN=CNTN2 PE=3 SV=3 CANONICAL=E1BPC9-1" }, "locus": { "chromosome": "16", "start_pos": 2855168, "end_pos": 2834727, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019501.8", "url": "https://www.ensembl.org/id/ENSBTAT00000019501.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019501.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019501.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100140960", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140960", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1ABR3-1", "protein_name": "Contactin-2", "gene_name": "CNTN2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "FLASAALVCTQLQAVFPSLAVWCQAQSGMRSYGPVFEEQPAHTLFPEGSAEEKVTLTCRARANPPATYRWKMNGTELKMGPDSRYRLVAGDLVISNPVKAKDAGSYQCVATNARGTVVSREASLRFGFLQEFSAEERDPVKITEGWGVMFTCSPPPHYPALSYRWLLNEFPNFIPADGRRFVSQTTGNLYIAKTEASDLGNYSCFATSHIDFITKSVFSKFSQLSLAAEDARQYAPSIKARFPADTYALTGQMVTLECFAFGNPVPQIKWRKLDGSQTSKWLSSEPLLHIQNVDFEDEGTYECEAENIKGRDTYQGRIIIHAQPDWLDVITDTEADIGSDLRWSCVASGKPRPAVRWLRDGQPLASQNRIEVSGGELRFSKLVLEDSGMYQCVAENKHGTVYASAELTVQALAPDFRLNPVKRLIPAARSGKVIIPCQPRAAPKATVLWTKGTELLTNSSRVTITADGTLILQNISKSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINVGENLTLQCHASHDPTMDLTFTWSLDDFPIDLDKSEGHYRRASVKEAVGDLAIVNAQLKHSGRYTCTAQTVVDSTSESATLTVRGPPGPPGGVVVRDIGDTTVQLSWSRGFDNHSPIARYSIEARTLLSNKWKQMRTNPVNIEGNAETAQVVNLIPWMDYEFRVLASNILGVGEPSLPSSKIRTKEAEAPTCRKRRLACSKPWPGQLVFSLSPTLRDYQNGDGFGYILSFRKKGTQGWLTARVPHAESLHYVYRNESIGPYTPFEVKIKAYNRKGEGPESLTAIVYSAEEEPKVAPFRVTAKAVLSSEMDVSWEPVEQGDMTGVLLGYEIRYWKDGDKEEAADRVRTAGLVTSAHVTGLNPNTKYHVSVRAYNRAGAGPPSPSTNITTTKPPPRRPPGNISWTLTGSTVTIKWDPVVAQADESAVTGYKMLYRQDSHSAPTLYLASKSRIDIPVPEDFTHAFVQIRVTGPGGDGTPAEVHIVRNSGTSMMVEDSVTRPVPHAAIITTNSLAMVALIRYLEL", "length": 1039 }, "evidence": [ { "id": "E1BPC9", "url": "https://omabrowser.org/oma/group/E1BPC9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P22063-1", "protein_name": "Contactin-2", "gene_name": "Cntn2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTHARKKASLLLLVLATVALVSSPGWSFAQGTPATFGPIFEEQPIGLLFPEESAEDQVTLACRARASPPATYRWKMNGTDMNLEPGSRHQLMGGNLVIMSPTKTQDAGVYQCLASNPVGTVVSKEAVLRFGFLQEFSKEERDPVKTHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDPRLFAPSIKARFPPETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWATAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPMVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRQNPVRRLIPAARGGEISILCQPRAAPKATILWSKGTEILGNSTRVTVTSDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINVGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRASAKETIGDLTILNAHVRHGGKYTCMAQTVVDGTSKEATVLVRGPPGPPGGVVVRDIGDTTVQLSWSRGFDNHSPIAKYTLQARTPPSGKWKQVRTNPVNIEGNAETAQVLGLMPWMDYEFRVSASNILGTGEPSGPSSKIRTKEAVPSVAPSGLSGGGGAPGELIINWTPVSREYQNGDGFGYLLSFRRQGSSSWQTARVPGADAQYFVYGNDSIQPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPAKVWAKGSSSSEMNVSWEPVLQDMNGILLGYEIRYWKAGDNEAAADRVRTAGLDTSARVTGLNPNTKYHVTVRAYNRAGTGPASPSADAMTVKPPPRRPPGNISWTFSSSSLSLKWDPVVPLRNESTVTGYKMLYQNDLHPTPTLHLTSKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGTSMMVESAAARPAHPGPAFSCMVILMLAGYQKL", "length": 1040 }, "evidence": [ { "id": "E1BPC9", "url": "https://omabrowser.org/oma/group/E1BPC9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61330-1", "protein_name": "Contactin-2", "gene_name": "Cntn2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGAPARKRASLLLLLLATMALVSSPGWSFSQGTPATFGPVFEEQPVGLLFPEESAEDQVTLACRARASPPATYRWKMNGTEMNLEPGSRHQLMGGNLVIMSPTKAQDAGVYQCLASNPVGTVVSKEAVLRFGFLQEFSKEERDPVKTHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHLDFSTKSVFSKFAQLNLAAEDPRLFAPSIKARFPPETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWGTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPMVRWLRNGEPLASQNRVEVLAGDLRFSKLNLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRQNPVRRLIPAARGGEISIPCQPRAAPKATILWSKGTEILGNSTRVTVTLDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINVGDNLTLQCHASHDPTMDLTFTWTLDDFPVDFDKPGGHYRRASVKETIGDLTILNAQLRHGGTYTCMAQTVVDGASKEATVLVRGPPGPPGGVVVRDIGDTTVQLSWSRGFDNHSPIAKYTLQARTPPSGKWKQVRTNPVNIEGNAETAQVLGLMPWMDYEFRVSASNILGTGEPSGPSSRIRTKEAVPSVAPSGLSGGGGAPGELTINWTPMSREYQNGDGFGYLLSFRRQGSSSWQTARVPGADTQYFVYSNDSIHPYTPFEVKIRSYNRRGDGPESLTAIVYSAEEEPKVAPAKVWAKGSSSSEMNVSWEPVLQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDSSARVTGLYPNTKYHVTVRAYNRAGTGPASPSADAMTMKPPPRRPPGNISWTFSSSSLSLKWDPVVPLRNESTVTGYKMLYQNDLQPTPMLHLTSKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGTSMMVESSAVRPAHPGPVFSCMVILMLAGCQRL", "length": 1040 }, "evidence": [ { "id": "E1BPC9", "url": "https://omabrowser.org/oma/group/E1BPC9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" }, { "name": "myelin sheath", "id": "GO:0043209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043209", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" }, { "name": "node of Ranvier", "id": "GO:0033268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033268", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" }, { "name": "axon initial segment", "id": "GO:0043194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043194", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" }, { "name": "juxtaparanode region of axon", "id": "GO:0044224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044224", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" }, { "name": "cell adhesion mediator activity", "id": "GO:0098631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098631", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "fat cell differentiation", "id": "GO:0045444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045444", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" }, { "name": "regulation of cell morphogenesis", "id": "GO:0022604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022604", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" }, { "name": "clustering of voltage-gated potassium channels", "id": "GO:0045163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045163", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" }, { "name": "establishment of protein localization to juxtaparanode region of axon", "id": "GO:0071206", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071206", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" }, { "name": "presynaptic membrane organization", "id": "GO:0097090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097090", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" }, { "name": "reduction of food intake in response to dietary excess", "id": "GO:0002023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002023", "evidence": [ { "database": "UniProtKB", "id": "E1BPC9", "url": "https://www.uniprot.org/uniprotkb/E1BPC9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 461, "end_pos": 463, "annotation": "n_glycosylation_sequon" }, { "start_pos": 477, "end_pos": 479, "annotation": "n_glycosylation_sequon" }, { "start_pos": 498, "end_pos": 500, "annotation": 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"MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPPPPHRGRLEAPAHAHQHVHVHPLLHHGPAQPHAHPHAHHHALPHPPPPHLSVPPRPWSYPRQAESDMSKPPCYEEAVMMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAPPCPALCLQSDRGRRVFPSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV", "length": 269, "header": "tr|E1BPD0-1|E1BPD0_BOVIN Isoform 1 of Proline rich 7, synaptic OS=Bos taurus OX=9913 GN=PRR7 PE=4 SV=1 CANONICAL=E1BPD0-1" }, "locus": { "chromosome": "7", "start_pos": 38953611, "end_pos": 38952587, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015147.3", "url": "https://www.ensembl.org/id/ENSBTAT00000015147.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015147.1", "url": "https://www.ensembl.org/id/ENSBTAP00000015147.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538641", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538641", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZJV2-1", "protein_name": "Proline rich 7, synaptic", "gene_name": "PRR7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPPPPHRGRLEAPAHGHQHVHVHPLLHHGPTQPHAHPHAHHHALPHPPPQPHLSVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAQPCPALCLQADRGRRVFPSWTDSELSSREPLEPGAWRLPVSIPLFGRTTAV", "length": 270 }, "evidence": [ { "id": "E1BPD0", "url": "https://omabrowser.org/oma/group/E1BPD0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XV12-1", "protein_name": "Proline rich 7, synaptic", "gene_name": "PRR7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSYLRRRVKRQQEERLREQSLRALELEPLHYEGYGGSPPGMAVPHRLRLEPHHHHHHHHHPHIPPPRPWSCRHESDLSKPPCYEEALLMAEPPPPYSEVLMDTRGLYRKINAPFLSHERLEKQEQPPSYKPLFLDTGYGSALHLPRSASPGPACPDLYLQAECSPRMFPSWTDSELSSRDTFEPGPWHLPVSMPLFGRTTAV", "length": 232 }, "evidence": [ { "id": "E1BPD0", "url": "https://omabrowser.org/oma/group/E1BPD0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7EXZ8-1", "protein_name": "Proline-rich protein 7 isoform X1", "gene_name": "prr7", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVMSQGTYTFLACFAGFWLIWALIVMLCCFCSFAQRKLKRRREERLREQCLRALEMEPLECTSGGYPPREPPQFCPPLQMLSPQLPVTHTLPQANWTVPEADTDVFGKPPCYEEAVLMEDPPPPYSEVLADPRGGTYTKPASSSSREHQESETSKMAPVTVFPECGYSSLIRLPSARRWDSLGHLLSNMDLNHNNLPVEPQASAIATMPREGRTHTDIGLRGLQSLDQHYGLPTAFPLLGRSTAV", "length": 245 }, "evidence": [ { "id": "E1BPD0", "url": "https://omabrowser.org/oma/group/E1BPD0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P0C6T3-1", "protein_name": "Proline-rich protein 7", "gene_name": "Prr7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPPPPHRSRLEAPVHAHSHVHVHPLLHHGPAQPHAHPHPHHHALPHPPPSHLSVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAAPCPALCLQADRSRRVFPSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV", "length": 269 }, "evidence": [ { "id": "E1BPD0", "url": "https://omabrowser.org/oma/group/E1BPD0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3V0I2-1", "protein_name": "Proline-rich protein 7", "gene_name": "Prr7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPPPPHRSRLEAPVHAHSHVHVHPLLHHGPAPPHAHPHPHHHALPHPPPPHLAVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAAPCPALCLQAERSRRVFPSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV", "length": 269 }, "evidence": [ { "id": "E1BPD0", "url": "https://omabrowser.org/oma/group/E1BPD0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TB68-1", "protein_name": "Proline-rich protein 7", "gene_name": "PRR7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPQPPPHRSRLEAPAHAHSHPHVHVHPLLHHGPAQPHAHAHPHPHHHALPHPPPTHLSVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAPPCPALCLQADRGRRVFPSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV", "length": 274 }, "evidence": [ { "id": "E1BPD0", "url": "https://omabrowser.org/oma/group/E1BPD0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "long-chain fatty acid binding", "id": "GO:0036041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036041", "evidence": [ { "database": "UniProtKB", "id": "E1BPD0", "url": "https://www.uniprot.org/uniprotkb/E1BPD0" } ], "pmid": "" }, { "name": "ubiquitin-like protein ligase binding", "id": "GO:0044389", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044389", "evidence": [ { "database": "UniProtKB", "id": "E1BPD0", "url": "https://www.uniprot.org/uniprotkb/E1BPD0" } ], "pmid": "" }, { "name": "protein tyrosine kinase binding", "id": "GO:1990782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990782", "evidence": [ { "database": "UniProtKB", "id": "E1BPD0", "url": "https://www.uniprot.org/uniprotkb/E1BPD0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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{ "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPE6-1", "uniprot_ac": "E1BPE6", "uniprot_id": "E1BPE6_BOVIN", "mass": { "chemical_mass": 30422.0, "monoisotopic_mass": 30422.0 }, "refseq": { "ac": "NP_001178300", "name": "gap junction beta-4 protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178300" }, "gene_names": [ { "name": "GJB4", "type": "recommended", "evidence": [ { "id": "E1BPE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPE6" } ] }, { "name": "CXNB", "type": "synonym", "evidence": [ { "id": "NP_001178300", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178300" } ] }, { "name": "GJB4", "type": "synonym", "evidence": [ { "id": "NP_001178300", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178300" } ] } ], "protein_names": [ { "name": "Gap junction protein", "type": "recommended", "evidence": [ { "id": "E1BPE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPE6/entry#names_and_taxonomy" } ] }, { "name": "connexin B", "type": "synonym", "evidence": [ { "id": "NP_001178300", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178300" } ] }, { "name": "gap junction beta-4 protein", "type": "synonym", "evidence": [ { "id": "NP_001178300", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178300" } ] }, { "name": "gap junction protein, beta 4, 30.3kDa", "type": "synonym", "evidence": [ { "id": "NP_001178300", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178300" } ] } ], "function": [ { "annotation": "Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response.", "evidence": [ { "database": "UniProtKB", "id": "E1BPE6", "url": "https://www.uniprot.org/uniprotkb/E1BPE6#function" }, { "database": "UniProtKB", "id": "RU000630", "url": "https://www.uniprot.org/uniprotkb/RU000630#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPE6", "url": "https://www.uniprot.org/uniprotkb/E1BPE6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GJB4", "url": "https://www.uniprot.org/uniprotkb/E1BPE6", "locus": { "chromosome": "3", "start_pos": 110926232, "end_pos": 110929601, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005719", "url": "https://www.ensembl.org/id/ENSBTAG00000005719" } ] } } ], "crossref": [ { "id": "ENSBTAG00000005719", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005719", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100140553", "url": "https://www.ncbi.nlm.nih.gov/gene/100140553", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013092", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013092", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019570", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019570", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100140553", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140553", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QDYDMPR", "url": "https://omabrowser.org/oma/group/QDYDMPR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPE6", "url": "https://www.orthodb.org/?gene=E1BPE6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11984", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11984:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11984:SF30", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00029", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00029", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-190861", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-190861", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001178300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178300", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BPE6", "url": "https://www.uniprot.org/uniprotkb/E1BPE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPE6-1", "url": "https://www.uniprot.org/uniprotkb/E1BPE6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNWAFLRDVLSGVNKYSTALGRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPGCPNVCYDQFFPVSHVRLWALQLILVTCPSLLVVMHVAYRQERERKHRRKHGPHAPSLYDNPDKKRGGLWWTYLLSLLFKAAVDVSFLYIFHRLYKDYDMPRVVACSESPCPNTVDCYISRPTEKKIFTYFMVATAVLCILLNLGEVSYLVGKRCLEILGPRPRGSRRPARLLEACPPYALSPGEHPQDGNSVLMKAEMTTVDAAGFP", "length": 266, "header": "tr|E1BPE6-1|E1BPE6_BOVIN Isoform 1 of Gap junction protein OS=Bos taurus OX=9913 GN=GJB4 PE=3 SV=3 CANONICAL=E1BPE6-1" }, "isoforms": [ { "isoform_ac": "E1BPE6-1", "url": "https://www.uniprot.org/uniprotkb/E1BPE6/entry", "sequence": { "sequence": "MNWAFLRDVLSGVNKYSTALGRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPGCPNVCYDQFFPVSHVRLWALQLILVTCPSLLVVMHVAYRQERERKHRRKHGPHAPSLYDNPDKKRGGLWWTYLLSLLFKAAVDVSFLYIFHRLYKDYDMPRVVACSESPCPNTVDCYISRPTEKKIFTYFMVATAVLCILLNLGEVSYLVGKRCLEILGPRPRGSRRPARLLEACPPYALSPGEHPQDGNSVLMKAEMTTVDAAGFP", "length": 266, "header": "tr|E1BPE6-1|E1BPE6_BOVIN Isoform 1 of Gap junction protein OS=Bos taurus OX=9913 GN=GJB4 PE=3 SV=3 CANONICAL=E1BPE6-1" }, "locus": { "chromosome": "3", "start_pos": 110928051, "end_pos": 110927254, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101173.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101173.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095676.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095676.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100140553", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140553", "resource": "KEGG Pathway" }, { "id": "R-BTA-190861", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-190861", "resource": "Reactome", "description": "Gap junction assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AT37-1", "protein_name": "Gap junction protein", "gene_name": "GJB4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNWAFLQGILSGVNKYSTALGRIWLSVVFLFRVLVYVVAAEEVWDDEQKDFICNTKQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYRQERERKHRLKHGPDARSLYDNPNKKRGGLWWTYLLSLIFKAAVDAGFLYIFHRLYRNYDMPRVVSCSEEPCPHTVDCYISRPTEKKVFTCFMVATAVICILLNLSEVTYLVGKRCLESLGPRHQRSRHQAHLPETCPPYALSQEEHPQDGNSAFMKAKTTAVAAGGYP", "length": 266 }, "evidence": [ { "id": "E1BPE6", "url": "https://omabrowser.org/oma/group/E1BPE6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P36380-1", "protein_name": "Gap junction beta-4 protein", "gene_name": "Gjb4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNWGFLQGILSGVNKYSTALGRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFICNTKQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHRLKHGPDAPALYSNLSKKRGGLWWTYLLSLIFKAAVDSGFLYIFHCIYKDYDMPRVVACSVQPCPHTVDCYISRPTEKKVFTYFMVVTAAICILLNLSEVAYLVGKRCMEVFRPRRQKTSRRHQLPDTCPPYVISKGHPQDESTVLTKAGMATVDAGVYP", "length": 265 }, "evidence": [ { "id": "E1BPE6", "url": "https://omabrowser.org/oma/group/E1BPE6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q02738-1", "protein_name": "Gap junction beta-4 protein", "gene_name": "Gjb4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNWGFLQGILSGVNKYSTALGRIWLSVVFIFRVLVYVVAAEEVWDDDQKDFICNTKQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHRLKHGPNAPALYSNLSKKRGGLWWTYLLSLIFKAAVDSGFLYIFHCIYKDYDMPRVVACSVTPCPHTVDCYIARPTEKKVFTYFMVVTAAICILLNLSEVVYLVGKRCMEVFRPRRRKASRRHQLPDTCPPYVISKGGHPQDESVILTKAGMATVDAGVYP", "length": 266 }, "evidence": [ { "id": "E1BPE6", "url": "https://omabrowser.org/oma/group/E1BPE6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NTQ9-1", "protein_name": "Gap junction beta-4 protein", "gene_name": "GJB4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNWAFLQGLLSGVNKYSTVLSRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHHLKHGPNAPSLYDNLSKKRGGLWWTYLLSLIFKAAVDAGFLYIFHRLYKDYDMPRVVACSVEPCPHTVDCYISRPTEKKVFTYFMVTTAAICILLNLSEVFYLVGKRCMEIFGPRHRRPRCRECLPDTCPPYVLSQGGHPEDGNSVLMKAGSAPVDAGGYP", "length": 266 }, "evidence": [ { "id": "E1BPE6", "url": "https://omabrowser.org/oma/group/E1BPE6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell-cell signaling", "id": "GO:0007267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007267", "evidence": [ { "database": "UniProtKB", "id": "E1BPE6", "url": "https://www.uniprot.org/uniprotkb/E1BPE6" } ], "pmid": "" }, { "name": "gap junction-mediated intercellular transport", "id": "GO:1990349", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990349", "evidence": [ { "database": "UniProtKB", "id": "E1BPE6", "url": "https://www.uniprot.org/uniprotkb/E1BPE6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "connexin complex", "id": "GO:0005922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005922", "evidence": [ { "database": "UniProtKB", "id": "E1BPE6", "url": "https://www.uniprot.org/uniprotkb/E1BPE6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "gap junction channel activity", "id": "GO:0005243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005243", "evidence": [ { "database": "UniProtKB", "id": "E1BPE6", "url": "https://www.uniprot.org/uniprotkb/E1BPE6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPE6" }, { "id": "SM00037", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00037" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Connexin N-terminal", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 75, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BPE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPE6" }, { "id": "SM01089", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Connexin cysteine-rich", "eco_id": "ECO_0000259", "start_pos": 141, "end_pos": 208, "start_aa": "Val", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], 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"count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPF2-1", "uniprot_ac": "E1BPF2", "uniprot_id": "E1BPF2_BOVIN", "mass": { "chemical_mass": 208908.0, "monoisotopic_mass": 208908.0 }, "refseq": { "ac": "XP_005221905", "name": "treslin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221905" }, "gene_names": [ { "name": "TICRR", "type": "recommended", "evidence": [ { "id": "E1BPF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPF2" } ] }, { "name": "TICRR", "type": "synonym", "evidence": [ { "id": "XP_005221905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221905" } ] } ], "protein_names": [ { "name": "TOPBP1 interacting checkpoint and replication regulator", "type": "synonym", "evidence": [ { "id": "E1BPF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPF2/entry#names_and_taxonomy" } ] }, { "name": "treslin", "type": "synonym", "evidence": [ { "id": "XP_005221905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221905" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPF2", "url": "https://www.uniprot.org/uniprotkb/E1BPF2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TICRR", "url": "https://www.uniprot.org/uniprotkb/E1BPF2", "locus": { "chromosome": "21", "start_pos": 21054212, "end_pos": 21011523, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002418", "url": "https://www.ensembl.org/id/ENSBTAG00000002418" } ] } } ], "crossref": [ { "id": "ENSBTAG00000002418", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002418", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "529868", "url": "https://www.ncbi.nlm.nih.gov/gene/529868", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032746", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032746", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:529868", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529868", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LYWMEKL", "url": "https://omabrowser.org/oma/group/LYWMEKL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPF2", "url": "https://www.orthodb.org/?gene=E1BPF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21556", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21556", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21556:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21556:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15292", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15292", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21854", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21854", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-69273", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69273", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005221905", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221905", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BPF2", "url": "https://www.uniprot.org/uniprotkb/E1BPF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPF2-1", "url": "https://www.uniprot.org/uniprotkb/E1BPF2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MACCHNVMLLLDTAGGVAGESLVRRAALRLLTYLSCRFGLARVRWAFRFFDSQGARSRPSRVSDFRELGVRSWEDFEEELEARLGDGAQGAHLPGPAPRASHTHSALMETLLDYQWDRPEITSPTKPILRNSGRRLLDVEGEAREAESALGGFVNAVFLLAPCPHSQRELLQFVSGSEAQAQRLPPTPKQVMEKLLPRKVQEVMRTRKITLYWVDTTEWPKLWESPDHLGYWTVCELLYHVGGTVLPFESFSQDFTKAGETLLSGERKLSSKPHLSSWISTLPTDSTLNCLLYNSPEYEASFPRIEGTLFFPVEGKELQETWTVTLEPLAMHQRHFQKPVRIFLKGTVTQWSLPTSGTLGTDSWMLQSPDGDRSTQRMLFQHLVNRLTAEELHLVASVDPGEGWPPITGVISPFSVGATVLTLFCTRETESQRHLLQTVVAESPQDSAALFSEVVDGVLKQIDSSLEVPATSDLPVPEWAQQELGRSAPWTSAIVEKWFPCSNLSGASSSLMESFWLLQATSSAKEEPSKTESDLTRGLSELYQRKSREEYSVSSQEDSRKKRGVPRTPVRKKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDTAGEKGIQKTANGRTADRLENRGRTLRSSKPKDFKTEEELLSHIHENYQKTVAAGDTMLYSCARSTISNIKAFLKSKGTKELEEASLEMNCLYQVRNNFLKTSKSLRQNVGKLDKEGKVRECQLQVFLRLELCLQCPSVHERVEDLEQVVGEVTDLLRMLCLTEDSAYLAKFLEGILELYIDSIPKILGSLYDSLGFVIPQKLAGVLPADFFSDDSMTQESKSPLSVPLPSNAHRSLPGGTESDQLEELRTRSAKKRRKNAIRHKSIAEVSQNLRQIEIPKVAKRATKNENSHPTLQQQPPLPVKDTVQEVTKVRRNLFNQEMISPSKRSVKKGLPRSHSVSAVEGLEYKRDSFKRTKGYRKLLTKSVAETPVHKQISGRLLHRQIKGRSSDPGPDIDVVEESPEKGEDVVSLRRSPRIKQLAFSRTNSASFYSVSQPKSRSIQRVHSFQQMKSDQRENSPVQSIRSPKRLLFGAMSEMISPSEKGSARIKRPSGNTVGSATPTAYQTPEKSYWKSPSSCKATPRKVPRTPQTPLRTPERLQKSPAEMTPAKQVIFKEFLKDLSPHGWDSPSQPKVTPRKGHSLAEGASSLEKVRRTPQRQSGQPPRFLQNSSWPHLVDSSPESTSCPAALVSSTAPTRTECLTPNRSSARAPPRTAASGLQRQAASKGTSPSQKHQLPQGSGAPRAEKLPQLWSNKAVKTPERPGNAALTFPKRAVTSLSCGISKESSLGEFPIASLSSGQGGWQEVQRSPSVTTPPSCSAPLTPPSASQVAPSDLWPPPPPSKHGKRHNKTSETEQDFLEGQPDSLAALRVAITDNPAAITDTGKNQKAATLSSPASPELPAYPGTGFGGDWHTSSPLLIATDSDCLTLLDEAEHHGHDNLKSSISPLDGGEGLRMGTCEKPSPCDPRILPTSPSSGPHSPLMPLYDPHCTADMKQCQAATQLEDQQAAPWPCGAPASPQTYEVELEMQASGLPKLRIKKIDSSSLPEVEPPPREESSLPGPSVPRASKSSGKPEATCLSAPCLRPSHSTPGKSGGQTYICQSCTPTHCPCGTPSPFQTEVGVPWTPSPKHSGKTTPDTIKDWPRRKRAVDCSLGPSAGRSEVSSDLPGGVLPLEPEGKERGLELGIGRPPILGDFELEGVCQLPDQSPPRDSVPKAEEAFSWGQFGLGSRKRCLSAEEAAERQVKRACDQQGDSEERSPSTSIRQLPSAADDEVFVPGATPPPGCAVRSCLSASGLQALTHSPLLFQGKTPSSQRKEARDEDVDVFSPTAEDSPFSRAFSRRRPIGRSYSRKKLLS", "length": 1902, "header": "tr|E1BPF2-1|E1BPF2_BOVIN Isoform 1 of TOPBP1 interacting checkpoint and replication regulator OS=Bos taurus OX=9913 GN=TICRR PE=4 SV=3 CANONICAL=E1BPF2-1" }, "isoforms": [ { "isoform_ac": "E1BPF2-1", "url": "https://www.uniprot.org/uniprotkb/E1BPF2/entry", "sequence": { "sequence": "MACCHNVMLLLDTAGGVAGESLVRRAALRLLTYLSCRFGLARVRWAFRFFDSQGARSRPSRVSDFRELGVRSWEDFEEELEARLGDGAQGAHLPGPAPRASHTHSALMETLLDYQWDRPEITSPTKPILRNSGRRLLDVEGEAREAESALGGFVNAVFLLAPCPHSQRELLQFVSGSEAQAQRLPPTPKQVMEKLLPRKVQEVMRTRKITLYWVDTTEWPKLWESPDHLGYWTVCELLYHVGGTVLPFESFSQDFTKAGETLLSGERKLSSKPHLSSWISTLPTDSTLNCLLYNSPEYEASFPRIEGTLFFPVEGKELQETWTVTLEPLAMHQRHFQKPVRIFLKGTVTQWSLPTSGTLGTDSWMLQSPDGDRSTQRMLFQHLVNRLTAEELHLVASVDPGEGWPPITGVISPFSVGATVLTLFCTRETESQRHLLQTVVAESPQDSAALFSEVVDGVLKQIDSSLEVPATSDLPVPEWAQQELGRSAPWTSAIVEKWFPCSNLSGASSSLMESFWLLQATSSAKEEPSKTESDLTRGLSELYQRKSREEYSVSSQEDSRKKRGVPRTPVRKKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDTAGEKGIQKTANGRTADRLENRGRTLRSSKPKDFKTEEELLSHIHENYQKTVAAGDTMLYSCARSTISNIKAFLKSKGTKELEEASLEMNCLYQVRNNFLKTSKSLRQNVGKLDKEGKVRECQLQVFLRLELCLQCPSVHERVEDLEQVVGEVTDLLRMLCLTEDSAYLAKFLEGILELYIDSIPKILGSLYDSLGFVIPQKLAGVLPADFFSDDSMTQESKSPLSVPLPSNAHRSLPGGTESDQLEELRTRSAKKRRKNAIRHKSIAEVSQNLRQIEIPKVAKRATKNENSHPTLQQQPPLPVKDTVQEVTKVRRNLFNQEMISPSKRSVKKGLPRSHSVSAVEGLEYKRDSFKRTKGYRKLLTKSVAETPVHKQISGRLLHRQIKGRSSDPGPDIDVVEESPEKGEDVVSLRRSPRIKQLAFSRTNSASFYSVSQPKSRSIQRVHSFQQMKSDQRENSPVQSIRSPKRLLFGAMSEMISPSEKGSARIKRPSGNTVGSATPTAYQTPEKSYWKSPSSCKATPRKVPRTPQTPLRTPERLQKSPAEMTPAKQVIFKEFLKDLSPHGWDSPSQPKVTPRKGHSLAEGASSLEKVRRTPQRQSGQPPRFLQNSSWPHLVDSSPESTSCPAALVSSTAPTRTECLTPNRSSARAPPRTAASGLQRQAASKGTSPSQKHQLPQGSGAPRAEKLPQLWSNKAVKTPERPGNAALTFPKRAVTSLSCGISKESSLGEFPIASLSSGQGGWQEVQRSPSVTTPPSCSAPLTPPSASQVAPSDLWPPPPPSKHGKRHNKTSETEQDFLEGQPDSLAALRVAITDNPAAITDTGKNQKAATLSSPASPELPAYPGTGFGGDWHTSSPLLIATDSDCLTLLDEAEHHGHDNLKSSISPLDGGEGLRMGTCEKPSPCDPRILPTSPSSGPHSPLMPLYDPHCTADMKQCQAATQLEDQQAAPWPCGAPASPQTYEVELEMQASGLPKLRIKKIDSSSLPEVEPPPREESSLPGPSVPRASKSSGKPEATCLSAPCLRPSHSTPGKSGGQTYICQSCTPTHCPCGTPSPFQTEVGVPWTPSPKHSGKTTPDTIKDWPRRKRAVDCSLGPSAGRSEVSSDLPGGVLPLEPEGKERGLELGIGRPPILGDFELEGVCQLPDQSPPRDSVPKAEEAFSWGQFGLGSRKRCLSAEEAAERQVKRACDQQGDSEERSPSTSIRQLPSAADDEVFVPGATPPPGCAVRSCLSASGLQALTHSPLLFQGKTPSSQRKEARDEDVDVFSPTAEDSPFSRAFSRRRPIGRSYSRKKLLS", "length": 1902, "header": "tr|E1BPF2-1|E1BPF2_BOVIN Isoform 1 of TOPBP1 interacting checkpoint and replication regulator OS=Bos taurus OX=9913 GN=TICRR PE=4 SV=3 CANONICAL=E1BPF2-1" }, "locus": { "chromosome": "21", "start_pos": 21053208, "end_pos": 21011656, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003143.8", "url": "https://www.ensembl.org/id/ENSBTAT00000003143.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003143.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003143.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1635, "start_aa": "Thr", "end_pos": 1635, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1635", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1658, "start_aa": "Thr", "end_pos": 1658, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1658", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1826, "start_aa": "Thr", "end_pos": 1826, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1826", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:529868", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:529868", "resource": "KEGG Pathway" }, { "id": "R-BTA-69273", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69273", "resource": "Reactome", "description": "Cyclin A/B1/B2 associated events during G2/M transition" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZIL1-1", "protein_name": "TOPBP1 interacting checkpoint and replication regulator", "gene_name": "TICRR", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MACSPSAVFLLDTASPGRRERLQLCALRLLNHLCCRFGLPRLRWAYRFFDSLGGRGGASRGGGFRPPAPRAWARFEEELAERLGARGSSAVLPGPATRLALTHSGLKETLLDFQWDRPEIASPTKAPRRSRGAGGELPASGAPSEGFVNAVFLFSPCPRSRRELRQFVSGGGAAPAEPPALQEVAEKLLPRSVRELLAEQRITLYWVDTAESSQLIKSPDHDGYWIMLQLLQQIGGTILPSETLYPSHHKADLADVFLRDSGSPVPQTVPWTTLLPSDSALNSLFSKPSVFYSVFPQQEGTLFLSMPEGKKESCAVILEPLAMSQRQLHCPFNIILKGSVMSWNWMQAVSFLTESWILKSSETECTEQNWLHQLLRSLVMKELHMIAEVSQTTSSCPCTAVLSPLSESSAVLTLFCTEKTAEVQRCNLEGAVVETSSPDDALHLPDVVHSVLSEIDMAVEDSLANTEETPVPEWVQRELSSTGGWHPSVLEAWYSSSNACGASSDLMDSFRLLQVPCTNVKDDADQSEVELLESLSELYQRKSSEISAGAGNNKKRRGVPRTPVRQKMKTMSRSLQMLNVARLNVKAQKFQPDGMPAVSEKVPQKLSAKRLDEKLEGKEKALKTSIDLKTEEELQSHLITSYQKVVAEEVLSSACAQNMIMAIKRFLKMQDTKEKEVACVEKVRNHLLKTSKLLRQQHGSEKETKVRECRLQVFLRLELCLQCPSLQNNADEMEQLLEEMTDMLRILCLTEDPGYLTKFLEEILELYMNSIPKTLGDLYYSLGTQIPPKLASVLPSDFFSDDSMTVDSKSPGLPLSLSSVLTPTAVCLQSESDQLEELRTRSAQKRRNNVLARHRSMTEASQNLRQIEIPKIDKNPIRKESSRSYLATEKSQQMPLQKEAVQEVTKVRRNLFNEGIRSPSKRTTKKMPRSQSVSAVEGLRYKCTDEGAKGHHKLLTKRVAETPLHKQVSRRLLHKQIKGRSSDPGCETGVVEESPEKAISEAGLRRSPRIRQLTLNRTHSGVFCSTVQPSSQNSQQVHWGQEEESCTQQDVAGVGLHSGCPTPKRFFFGAVIDACSPTVKRSPGRRRTRKDSLNLEELTACQTPRKTPLKSAQKLLNSASKPLRRSPRILHRTPQKVEKTPSKSPAAKQTAAKCLGKYFSHPAPRIRSPSVLTEGKRACLMQVTKDCSPAEKLFSPYKETDLQLPEHNEILSTVNPSPPQDSAPAAASLPATQKSIFAELQTPRRSLRSLSKFASPVGARRQILPREIEMQPEPASQTTETTPRKAEDPGSKLPTSPLSDVEMSQLTVKLESPFSSPLSEKATNTAAVSSPSHTEAKESDREFNVPENSLLKSPGVGGTLLESPLNNSKQAKGNPDSGGENHTCVCETPSKSKGGHRDNGDNSCVESLQFCKSQIPENNHILENKQMDAVAQNSPPRKDSKNLEKHSSPKLSAGEHMLNAEMECEQSSKEGNSSVSTCESFLSSSQTSIDELEPKTPQREECTGPKAPSLKRRSRSARNTSPPLPKSAPAYSLRYTADRRQREAAARMGNPELPAKFSAPKIPCQQPSESSTAYEVELEMQASGLPKLRFKKIGSCSALDVQSETNVSKPKGGESPFGDLAMTWCSKHPGKLAAACVSPSCFRSFHGTPGKGGGQTYICQSYTPTSCASNTTSPSPLEAEVPLTPPKLKGKTTPDAIKDWPRRKRAVSSTANSSCVQSEKNADEAMSTSREGKLKDLENCSSKVTCAFGEFELEGIYRLQDQVSPNDTEPRDEERSAMGASGLTSRKRVFTYLSPEKEENHEAKRACTDKCNMVLNAFSPEEGNRNKARTDLVLPEKPRACLLLTPRQHICIGDDDVFPLSGATPPVKSSLSASSLLALTQSPLLCKGQTPPSRRKCVQDEESDDPEVITNQELSPFHSMASRRRSLSRTYSRKRLLS", "length": 1938 }, "evidence": [ { "id": "E1BPF2", "url": "https://omabrowser.org/oma/group/E1BPF2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0L4N7-1", "protein_name": "TOPBP1-interacting checkpoint and replication regulator", "gene_name": "Ticrr", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MACCHKVMLLVDTAGDAARHSSARRAALRLLTYLSCRFGLARVHWTFKFFDSQGARNRPSRVSDFRELGSRSWEDFEEELEARLGDRPPGAHLPGPTPRATHTHGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDADSEAKEAETALGGFGNAVFLLAPCPHSQRELLQFVSGCEAQAQRVPLTPKQLMEKVLPKRVQEVMIARNITLYWVDTTERSKLWASPDHTGYWTVCELLHHGGGTILPAETWNLGFTKARETVLPCGGELSPGPHLSPWISALPIDATVNCLLYNSEYEASFPRVEGTLFLPVKGKEIQETWAICLEPLAMHQRHFQKPVRIFLKGSVTQWSLPMSSALGTDNWMLQSPEEHKSTQRLLFQELVSRLTAEEFHLVASVDPGDGWPPITGIISPFSANAMILTVLRAKEAEFQRHFLQTAVTEGSQDVTSLFSDAVDSVLNQVHNSFEDPASSVSRVPEWVQQELSRTSPWSPALVEKWFPFSNVCGATSDLMESFLLLHAASPDNNESSRTESELTRCLSELYQRRSHEESTVVNQERSRKKRGIPRTPVRQKMNTMSRSLKMLNVARLNVKAQKLHPDGSPDMAVEKGLPKTVIGRTADKLEDRGRVLRSSKLKEFKTEEELLAYIHDNYQKTVATGEITLHSCAQNTVSTIKIFLKSKDVKELEMTCMNHMNSNLLKTSKTLRQNLGGKTDKEDKVRECQLQVFLRLEMCQQCPSVLDRTEEVEHVVEEVTDLLRVVCLTKDSAYLSEFLEEILGLYIDSIPGTIGQLYHSLGLKIPQKLAGVLPTDFFSDDSMTQESMSPPPSSSTHRSVSAITESEQLEELRTRSAKKRRKNALIRHKSIAEISQALRQIEVPKVSKRATRSASNPRTWSTEESAHPASVQLPLPRKDTVQEVTKVRRNLFNQGMLSPSKRGLKKGLPRSRSVSTLECLQHKQDKLKKTKSSTFQGYKLLTKSVAETPVHKQISRRLLHRQIKGRSSDPGPDIHVVEESPEKEDEMILRRSPRIKQLSFSRTNSGSFYSVSQPKSRSVQRIHSSQQKSDQRENFPVQSIRSPKTLLFGALSETPSSSKKGSPGIKRSSRSMLDSEISTAYETPKKNNQKSPSFSKTTPRSFPRTAQTLLYTPERLQNSSTEITSAEGTISEVAIKTPSSHGYNSPSASKVTPQKRASPAKEETSPLTELPSIPRESDVQPPQCSSNSVSSSSEGPCCPASPPPLAGQARGQCLTPVRYSFRTPPRTALAVTSTYQEHQELPLRRASQAREPPQRLEEKALKIPKKPTDTSTSPLSPKEHFTSPGCNVSPHQPSISSLSASPSGELSWKENQTSPSVTTSVSCPVPSTPPRTPQRMICPIPPSPPSKLRRPCRKKSCLPQDFPECQPGPCAVPVLGTTTSPGTVRGSREEQSQPSEGHSYLGTSFGSDWHVSSPMLIASDTECLPLIDEAQLHRLENQEVKSGVLPGEEGEEPETTTAEPPSVSDLGILVPAPSSVSNSPELLSYTLCRVADGRQSHDAAQQESPPASEATDSPQTYDVELEMQASGLPKLRIKKIDPGVLLEPEALGRETLLGEEGTFPALSMPKASKSSGRSEHTYLSPPCLLPSHSTPGKSGGQTFICQSCTPSRCPPSTPSPFQADVGVSWTPSPKQSGKTTPEIIKDWPRRKRAVDCSAGPSAGRGEASMDLPGSLSLLEPEPEGKEQSLEQDLCKVLILEDFELEGVCQLPDQSPPKHSVSMAEETSWEQFGLGRKRLLSAKEESEYNGKRLCDSPSEDPQASEHKECSPCWSAPPVPSVGDDEVFVSGSTPPSGYMVRSCLSASGLQALTQSPLLFQGRTPSSHSKDTRDEDVDVFPSTAEESPFSQTLSRKRPFRTYTRKKLIS", "length": 1894 }, "evidence": [ { "id": "E1BPF2", "url": "https://omabrowser.org/oma/group/E1BPF2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SK20-1", "protein_name": "TOPBP1 interacting checkpoint and replication regulator", "gene_name": "TICRR", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MACCHNVMLLLDTAGGAAGESPVRRAALRLLTYLSCRFGLARVRWAFRFFDSQGARSRPSRVSDFRELGVRSWEDFEEELEARLGDGARGAHLPGPAPRATHTHSALMETLLDYQWDRPEITSPTKPILRSSRRRLLDVEGEAKEAASALGSFVNAVFLLGPCPHSQRELLQFVAGCEAQAQRLPPSPKQVMDKLLPRRVQEVMIARKITLYWVDTTEWSKLWESPDHVGYWTVCELLRHVGGTVLPFETFSQDFTKTGGMPLGSESKLFREPRLSSWISTLPTDSTLNCLLYNSHEYEASFPRMEGTLFLPVEGKETQETWTVMLEPLAMYQRHFQKPVRIFLKGTVTKWSLPTSGPLSTDSWMLQSLEGNRSTQRMLFQQLVNRLAAEELHLVASVDPGEGWPPITGVISPFSASATVLTVFHAKETEFQRHFVQTVLAERPQDSASLLSEVMDGVLNQIHHSLEDPATSAPPVPEWAQQELGRTTPWSSTIVEKWFPCSNLSGASSNLMESFWLLQAASSNKEESSKTESELTRCLSEFYQGKSREESTGYNQEDSRKKRGVPRTPVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDTAGEKGIQKIASGRTTDKLENRGRTLRSSKPKGFKTEEELLSYIHENYQKTMATGEITLYSCARNMISNIKAFLKSRGPKELDMNCLHQVRNNLLKTSKSLRQNVGKLDKEDKVRECQLQVFLRLELCLQCPSIHESIDDMEQVVEEMTDLLRMMYLTEDSAYLAKFLEEILGLYSDSIPETLGKLYNSLGFVIPQKLAGVLPTDFFSDDSMTQESKSPLSVPLMSSAHRSVSGGTESDQLEELRTRSAKKRRKNAIRHKSIAEVSQNLRQIEIPKVSKRATKNENSQPSLQQPPLPVKETVQEVTKVRRNLFNQEMISPSKRSVKRGLPRSHSVSAVEDLDNFKRTKGFHKLLTKSVAETPVHKQISRRLLHRQIKGRSSDPGPDIDVVEESPEKGEDEVSLRRSPRIKQLSFGRTNSGSFYSVSQPKSRSIQRVHSFQQVKSDQRENSPIQSIRSPKRLLFGAVSEMISPSEKGSARIKRPSGNTMDSAMLTAYQTPEKRSWKCPSSKATPRRYPHTPQTPLRTPERLQGSPAEMTPAKQVIFKEFLKEDSSHSWDSPCQSKVTPRKGLSLVEGASPLKTILRTPQRPGSQPSRFLQNSSWPSLVNSSPESTSCSAAVVPSTAQTRGECLTPIRYSPRTPSRAAALRVQGEAAFMGTPPTQKHQLPWGSAASQAEKLARQRKNEAVKTPGRPGDTALTSPKKPLTSSLCAVSKSPFRKLPVDSPPPGEQDWREVQKSASTAPSPCCPPSTPSKIWQRAGPAPRPPPPPSKTGTGPRKASEAQSHFLEGQPHSSAALRAAMTDSPAPITDTRKKQEEAALSPLPSPESHSHHAADFGDDWCASPQLLTAGDSAFLTLLDEAQHRGSENLKSSVDPVEEGEASRTVAADEKPSPPHPGIPPPSPSSEPSSPATPSYDLRCTAGRRQHRAAAQLETLRAASWPSGASPGPQTYEVELEMQASGLPKLRIKKVDPGSLSEAETLRGEESALPGLSIPRPSKSSGKPEATYLSPPCLRPSHSTPGKSRGQTYICQSCTPTRCPSSTPSPFQTDGVVPWTPSPKHSGKTTPDTIKDWPRRKRAVDCSLGPSAGRGEVSGDFPGGMWLLEPEGKEQGLGLSITKTPILGDFELGVCKLPDQSPLRDSVPKAEEAASWGQFGLGSRKRFLSAEGEAEGQAKRVCDEQKGDSEVTRSEETSPGTSARQLPSSGEDDEVFASGATPPPSYAVRSCLSASSLQALTHSPLLFQTKMPSSRGKDAREEDVEVFPSAAEDSPFSRALSRRRPISRTYTRKKLIS", "length": 1896 }, "evidence": [ { "id": "E1BPF2", "url": "https://omabrowser.org/oma/group/E1BPF2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q7Z2Z1-1", "protein_name": "Treslin", "gene_name": "TICRR", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MACCHKVMLLLDTAGGAARHSRVRRAALRLLTYLSCRFGLARVHWAFKFFDSQGARSRPSRVSDFRELGSRSWEDFEEELEARLEDRAHLPGPAPRATHTHGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDVESEAKEAEAALGGLVNAVFLLAPCPHSQRELLQFVSGCEAQAQRLPPTPKQVMEKLLPKRVREVMVARKITFYWVDTTEWSKLWESPDHLGYWTVCELLHHGGGTVLPSESFSWDFAQAGEMLLRSGIKLSSEPHLSPWISMLPTDATLNRLLYNSPEYEASFPRMEGMLFLPVEAGKEIQETWTVTLEPLAMHQRHFQKPVRIFLKGSVAQWSLPTSSTLGTDSWMLGSPEESTATQRLLFQQLVSRLTAEELHLVADVDPGEGRPPITGVISPLSASAMILTVCRTKEAEFQRHVLQTAVADSPRDTASLFSDVVDSILNQTHDSLADTASAASPVPEWAQQELGHTTPWSPAVVEKWFPFCNISGASSDLMESFGLLQAASANKEESSKTEGELIHCLAELYQRKSREESTIAHQEDSKKKRGVPRTPVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDVAGEKGIQKIPSGRTVDKLEDRGRTLRSSKPKDFKTEEELLSYIRENYQKTVATGEIMLYACARNMISTVKMFLKSKGTKELEVNCLNQVKSSLLKTSKSLRQNLGKKLDKEDKVRECQLQVFLRLEMCLQCPSINESTDDMEQVVEEVTDLLRMVCLTEDSAYLAEFLEEILRLYIDSIPKTLGNLYNSLGFVIPQKLAGVLPTDFFSDDSMTQENKSPLLSVPFLSSARRSVSGSPESDELQELRTRSAKKRRKNALIRHKSIAEVSQNLRQIEIPKVSKRATKKENSHPAPQQPSQPVKDTVQEVTKVRRNLFNQELLSPSKRSLKRGLPRSHSVSAVDGLEDKLDNFKKNKGYHKLLTKSVAETPVHKQISKRLLHRQIKGRSSDPGPDIGVVEESPEKGDEISLRRSPRIKQLSFSRTHSASFYSVSQPKSRSVQRVHSFQQDKSDQRENSPVQSIRSPKSLLFGAMSEMISPSEKGSARMKKRSRNTLDSEVPAAYQTPKKSHQKSLSFSKTTPRRISHTPQTPLYTPERLQKSPAKMTPTKQAAFKESLKDSSSPGHDSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPPGFLPNCTWPHSVNSSPESPSCPAPPTSSTAQPRRECLTPIRDPLRTPPRAAAFMGTPQNQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPLCDVSKKSPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSKVGKRCRKTSDPRRSIVECQPDASATPGVGTADSPAAPTDSRDDQKGLSLSPQSPPERRGYPGPGLRSDWHASSPLLITSDTEHVTLLSEAEHHGIGDLKSNVLSVEEGEGLRTADAEKSSLSHPGIPPSPPSCGPGSPLMPSRDVHCTTDGRQCQASAQLDNLPASAWHSTDSASPQTYEVELEMQASGLPKLRIKKIDPSSSLEAEPLSKEESSLGEESFLPALSMPRASRSLSKPEPTYVSPPCPRLSHSTPGKSRGQTYICQACTPTHGPSSTPSPFQTDGVPWTPSPKHSGKTTPDIIKDWPRRKRAVGCGAGSSSGRGEVGADLPGSLSLLESEGKDHGLELSIHRTPILEDFELEGVCQLPDQSPPRNSMPKAEEASSWGQFGLSSRKRVLLAKEEADRGAKRICDLREDSEVSKSKEGSPSWSAWQLPSTGDEEVFVSGSTPPPSCAVRSCLSASALQALTQSPLLFQGKTPSSQSKDPRDEDVDVLPSTVEDSPFSRAFSRRRPISRTYTRKKLMGTWLEDL", "length": 1910 }, "evidence": [ { "id": "E1BPF2", "url": "https://omabrowser.org/oma/group/E1BPF2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BQ33-1", "protein_name": "Treslin", "gene_name": "Ticrr", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MACCHKVMLLVDTAGVSAPHSPARRAALRLLTYLSCRFGLARVHWTFKFFDSQGARSRPSRVSDFRELGSRSWEDFEEELEARLGDRPPGAHLPGPTPRATHTHGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDADGEAREAQAALGGFGNAVFLLAPCPHSQRELLQFVSGCEAQAQRVPLTPKQVMEKVLPKRVQEVMIARNITLYWVDTTERSKLWASPDHVGYWTVCELLHHGGGTILPAETWSLGFTKARETVLPCGGELSHKPHPSPWISALPIDATVNCLLYNSEYEASFPRIEGTLFLPVQGKEIEETWAISLEPLAMHQRHFQKPVRIVLRGSVAQWSLPVSSALGTDSWMLQSPEEHRSTQRLLFQELVSRLTAEEFHLVASVDPGEGWPPITGIISPFSANAMILTVFRAKEAEFQSHFLQTAATEGSQDTASLFSDVVDSVLNQSHNLFEDPASSAPCVPEWVQQELSHTSSWSPALVEKWFPFSNASGATSDLMESFWLLHAASPDNDESSKTESELTRCLSELYQRSHEESTVVNQERSRKKRGIPRTPVRQKMNTMSRSLKMLNVARLNVKAQKLHPDGSPDTAVEKGLQKAVIGRTADKLEDRGRILRSSKLKEFKTEEELLAYIHDNYQKAVATEEITLYSCAQNMVSTIKMFLKSKDIKELEVACLSHVNSNLLKTSKTLRQNLAGKMDTEDKVGECQLQVFLRLEMCEQCPSVLDRPDEVERIVEEVTDLLRLVCLTKDSAYLSEFLEEILRLYIGSIPGTIGQLYHSLGLKIPQKLAGVLPTGFFSDDSMSQESMSPPPSSSTHRSVSAITESEQLEELRTRSAKKRRKNALIRHKSIAEISQTLRQIEVPKVSKRATRNENSHSASIQLPVPRKDTIQEVTKVRRNLFNQEMLSPSKRGLKKGLPRSHSVSALECLHHKQDKFKKTKSSTFQGYCKLLTKSVAETPVHKQISRRLLHRQIKGRSSDPGPDIHVVEESPEKEDEMTLRRSPRIKQLSFSRTNSGSFYSVSQPKSRSVQRIHSSQQESEQRENFPVQSIQSPKTLLFGALSEIPSSSKKGSAQIKRSLRSMLDSEISTSYETPKKSNQKSPSFSKTTPRRFPRTAQTLLYTPERLQNSPTEMTSAEGTISEATIKTPSSHGYNSPFASKVTSQKTVSPAKEETSPPLTKLPSTPRESDVQPPQCSSDCTWPHSVNSSPEGPYYPASPPPMAGQARSQCLTPIRYSFRTPPRTALAGTSKQQEHQELPLPRASQTQEPPQGLEKKALKIPKKPAHTSTSPLSPEEHYSGCDVSPHQPRNSLSASPPPGELNWKEHQTSPSVTSSVSCPVPSTPPRTPQRMTCPIPPSPPSKLRRSCRKKSCPPQDFPECHPGPSAAPVLSSATSPGAVTGSREEQSQFSEGQSYLGTGFRSDCHVSSPVLTASDTKCLPLIDEAQLHGLKNQEVKSGILPGEEGEEPESTIADELPSVSDPGILVPAPSSVSSSSELLPYPLCCTADGKQRQDAAQQGSPRASEATSSPQTYEVELEMQASGLPKLRIKKIDPGVLLEAEALGKEAPLGEEGALPALCMPKASKSSGRTEHPYLSPPCLRPSHSTPGKNGGQTFICQSCTPSRCPPSTPSPFQADAGVSWTPSPKQSGKTTPEIIKDWPRRKRAVDCSAGPSAGRGEASMDLPGSLSLLEPEPEGKERSLEQDLSKVLISEEFELEGVCQLPDQSPPKDSASVTEETSWGQFGLGRKRFLSAKEESEYKVKRVCDSLSEDPQASKQKECSPRWSALPLHSVGDDEVFVSGSTPPSGCMVRSCLSASGLQALTQSPLLFQGRTPSSHSTDTRDEEVDVFPSTAEESPFSHTLSRKRPFRTYTRKKLIS", "length": 1889 }, "evidence": [ { "id": "E1BPF2", "url": "https://omabrowser.org/oma/group/E1BPF2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of DNA-templated DNA replication initiation", "id": "GO:0030174", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030174", "evidence": [ { "database": "UniProtKB", "id": "E1BPF2", "url": "https://www.uniprot.org/uniprotkb/E1BPF2" } ], "pmid": "" }, { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "E1BPF2", "url": "https://www.uniprot.org/uniprotkb/E1BPF2" } ], "pmid": "" }, { "name": "response to ionizing radiation", "id": "GO:0010212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010212", "evidence": [ { "database": "UniProtKB", "id": "E1BPF2", "url": "https://www.uniprot.org/uniprotkb/E1BPF2" } ], "pmid": "" }, { "name": "mitotic G2 DNA damage checkpoint signaling", "id": "GO:0007095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007095", "evidence": [ { "database": "UniProtKB", "id": "E1BPF2", "url": "https://www.uniprot.org/uniprotkb/E1BPF2" } ], "pmid": "" }, { "name": "mitotic DNA replication checkpoint signaling", "id": "GO:0033314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033314", "evidence": [ { "database": "UniProtKB", "id": "E1BPF2", "url": "https://www.uniprot.org/uniprotkb/E1BPF2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "E1BPF2", "url": "https://www.uniprot.org/uniprotkb/E1BPF2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BPF2", "url": "https://www.uniprot.org/uniprotkb/E1BPF2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BPF2", "url": "https://www.uniprot.org/uniprotkb/E1BPF2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1214, "end_pos": 1216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1249, "end_pos": 1251, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1394, "end_pos": 1396, "annotation": "n_glycosylation_sequon" }, { "start_pos": 503, "end_pos": 505, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPF2" }, { "id": "PF15292", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15292" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Treslin M", "eco_id": "ECO_0000259", "start_pos": 281, "end_pos": 424, "start_aa": "Thr", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BPF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPF2" }, { "id": "PF21854", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21854" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Treslin N-terminal", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 202, "start_aa": "His", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BPF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPF2" }, { "id": "PF21855", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21855" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Treslin STD", "eco_id": "ECO_0000259", "start_pos": 641, "end_pos": 798, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1635, 1658, 1826 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1214, "end_pos": 1216 }, { "start_pos": 1249, "end_pos": 1251 }, { "start_pos": 1394, "end_pos": 1396 }, { "start_pos": 503, "end_pos": 505 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1M4F4-1", "uniprot_ac": "A0A3Q1M4F4", "uniprot_id": "A0A3Q1M4F4_BOVIN", "mass": { "chemical_mass": 47887.0, "monoisotopic_mass": 47887.0 }, "refseq": {}, "gene_names": [ { "name": "KRT12", "type": "recommended", "evidence": [ { "id": "A0A3Q1M4F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4" } ] }, { "name": "KRT17", "type": "recommended", "evidence": [ { "id": "A0A3Q1M4F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4" } ] }, { "name": "KRT17", "type": "synonym", "evidence": [ { "id": "A0A3Q1M4F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4" } ] } ], "protein_names": [ { "name": "Keratin, type I cytoskeletal 17", "type": "recommended", "evidence": [ { "id": "A0A3Q1M4F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4/entry#names_and_taxonomy" } ] }, { "name": "Cytokeratin-17", "type": "synonym", "evidence": [ { "id": "A0A3Q1M4F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4/entry#names_and_taxonomy" } ] }, { "name": "Keratin-17", "type": "synonym", "evidence": [ { "id": "A0A3Q1M4F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4F4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRT12", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4", "locus": { "chromosome": "19", "start_pos": 41053696, "end_pos": 41059191, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015518", "url": "https://www.ensembl.org/id/ENSBTAG00000015518" } ] } } ], "crossref": [ { "id": "A0A3Q1M4F4", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1M4F4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006806", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006806", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "281889", "url": "https://www.ncbi.nlm.nih.gov/gene/281889", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:281889", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281889", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QYKTKEP", "url": "https://omabrowser.org/oma/group/QYKTKEP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A140T867", "url": "https://www.orthodb.org/?gene=A0A140T867", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M4F4", "url": "https://www.orthodb.org/?gene=A0A3Q1M4F4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MJ66", "url": "https://www.orthodb.org/?gene=F1MJ66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N2P6", "url": "https://www.orthodb.org/?gene=G3N2P6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239:SF180", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239:SF180", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239:SF369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239:SF369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A140T867", "url": "https://www.uniprot.org/uniprotkb/A0A140T867", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T867-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T867-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4F4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M4F4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ66", "url": "https://www.uniprot.org/uniprotkb/F1MJ66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ66-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2P6", "url": "https://www.uniprot.org/uniprotkb/G3N2P6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2P6-1", "url": "https://www.uniprot.org/uniprotkb/G3N2P6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTTIRHFSSGSIKGSSGLAGGSSRSCRVSGSLGGGSCRLGSAGGLGSGLGGSSYSSCYSFGSGGSYGSGFGGVDGLLVGGEKATMQNLNDRLASYLDKVRALEEANTELELKIRDWYQKQAPGPAPDYSSYFKTIEDLRNKIHTATVDNANLLLQIDNARLAADDFRTKFETEQALRVSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLRKNHEEEMKALRGQVGGEINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTLQALEIELQSQLSMKASLEGSLAETENRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKTKEPVTTRQVRTIVEEVQDGRVISSREQVHQTSH", "length": 431, "header": "tr|A0A3Q1M4F4-1|A0A3Q1M4F4_BOVIN Isoform 1 of Keratin, type I cytoskeletal 17 OS=Bos taurus OX=9913 GN=KRT12 PE=3 SV=2 CANONICAL=A0A3Q1M4F4-1" }, "isoforms": [ { "isoform_ac": "A0A140T867-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T867/entry", "sequence": { "sequence": "MTTTIRHFSSGSIKGSSGLAGGSSRSCRVSGSLGGGSCRLGSAGGLGSGLGGSSYSSCYSFGSGGSYGSGGYVSGGYGGGFGGVDGLLVGGEKATMQNLNDRLASYLDKVRALEEANTELELKIRDWYQKQAPGPAPDYSSYFKTIEDLRNKIHTATVDNANLLLQIDNARLAADDFRTKFETEQALRVSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLRKNHEEEMKALRGQVGGEINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTLQALEIELQSQLSMKASLEGSLAETENRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKTKEPVTTRQVRTIVEEVQDGRVISSREQVHQTSH", "length": 441, "header": "tr|A0A140T867-1|A0A140T867_BOVIN Computationally mapped isoform of Keratin, type I cytoskeletal 17 OS=Bos taurus OX=9913 GN=KRT17 PE=3 SV=1 CANONICAL=A0A3Q1M4F4-1" }, "locus": { "chromosome": "19", "start_pos": 41840058, "end_pos": 41834757, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008948.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008948.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008948.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008948.5" } ] } }, { "isoform_ac": "A0A3Q1M4F4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4/entry", "sequence": { "sequence": "MTTTIRHFSSGSIKGSSGLAGGSSRSCRVSGSLGGGSCRLGSAGGLGSGLGGSSYSSCYSFGSGGSYGSGFGGVDGLLVGGEKATMQNLNDRLASYLDKVRALEEANTELELKIRDWYQKQAPGPAPDYSSYFKTIEDLRNKIHTATVDNANLLLQIDNARLAADDFRTKFETEQALRVSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLRKNHEEEMKALRGQVGGEINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTLQALEIELQSQLSMKASLEGSLAETENRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKTKEPVTTRQVRTIVEEVQDGRVISSREQVHQTSH", "length": 431, "header": "tr|A0A3Q1M4F4-1|A0A3Q1M4F4_BOVIN Isoform 1 of Keratin, type I cytoskeletal 17 OS=Bos taurus OX=9913 GN=KRT12 PE=3 SV=2 CANONICAL=A0A3Q1M4F4-1" }, "locus": { "chromosome": "19", "start_pos": 41840058, "end_pos": 41834757, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071728.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071728.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064687.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064687.2" } ] } }, { "isoform_ac": "F1MJ66-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ66/entry", "sequence": { "sequence": "IGPSSSTMSLSVRTSGLPQWLSSQSGTLGRARGMSASSIGSGYGGSAFGFGGNSGGGFSAASMFGSSSGFGGACGSSFAGGLGAGYGGAGGGGFGGLGIGFGGSSGGGSLGILPGIDGGLISGSEKETMKNLNDRLASYLDKVRALEEANTDLETKIREWYETRGSGTGDPGSQNDYSKYYPLIEDLRNKIISANIENAQLILQIDNARLAADDFRMKYENELALCQNVEADINGLRRVLDELTLARADLETQIETLNEELAYLKKNHEEELQSCRAGGPGQVSVEMDAAPGVDLTRLLNDMRAQYETIAEQNRKDAEAWFIEKSGELRKEISSNTEQLQSSKSEVTDLRRALQNLEIELQSQLAMKKSLEDSLAETEGDYCGQLSQVQQLIGSLEEQLLQVRADAERQSADYQRLLNVKARLELEIETYRRLLDGEAQGDSLVESSYVTASTSQAPSTDSSKDPNKARKIKTIVQEVVNGEVVSSQVKEIEELM", "length": 495, "header": "tr|F1MJ66-1|F1MJ66_BOVIN Computationally mapped isoform of Keratin 12 OS=Bos taurus OX=9913 GN=KRT12 PE=3 SV=4 CANONICAL=A0A3Q1M4F4-1" }, "locus": { "chromosome": "19", "start_pos": 41059191, "end_pos": 41053699, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020622.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020622.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020622.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020622.7" } ] } }, { "isoform_ac": "G3N2P6-1", "url": "https://www.uniprot.org/uniprotkb/G3N2P6/entry", "sequence": { "sequence": "MTTTIRHFSSGSIKGSSGLAGGSSRSCRVSGSLGGGSCRLGSAGGLGSGLGGSSYSSCYSFGSGGSYGSGGYVSGGYGGGFGGVDGLLVGGEKATMQNLNDRLASYLDKVRALEEANTELELKIRDWYQKQAPGPAPDYSSYFKTIEDLRNKIHTATVDNANLLLQIDNARLAADDFRTKFETEQALRVSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLRKNHEEEMKALRGQVGGEINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTLQALEIELQSQLSMKASLEGSLAETENRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHHPECLSPAAVTTRQVRTIVEEVQDGRVISSREQVHQTSH", "length": 441, "header": "tr|G3N2P6-1|A0A3Q1M4F4_BOVIN Computationally mapped isoform of Keratin, type I cytoskeletal 17 OS=Bos taurus OX=9913 GN=KRT12 PE=3 SV=3 CANONICAL=A0A3Q1M4F4-1" }, "locus": { "chromosome": "19", "start_pos": 41840058, "end_pos": 41834757, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066349.3", "url": "https://www.ensembl.org/id/ENSBTAT00000066349.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056163.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056163.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:281889", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:281889", "resource": "KEGG Pathway" }, { "id": "R-BTA-6805567", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "resource": "Reactome", "description": "Keratinization" }, { "id": "R-BTA-6809371", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" } ], "orthologs": [ { "uniprot_canonical_ac": "Q04695-1", "protein_name": "Keratin, type I cytoskeletal 17", "gene_name": "KRT17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTTSIRQFTSSSSIKGSSGLGGGSSRTSCRLSGGLGAGSCRLGSAGGLGSTLGGSSYSSCYSFGSGGGYGSSFGGVDGLLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQRQAPGPARDYSQYYRTIEELQNKILTATVDNANILLQIDNARLAADDFRTKFETEQALRLSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGNLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKKEPVTTRQVRTIVEEVQDGKVISSREQVHQTTR", "length": 432 }, "evidence": [ { "id": "A0A3Q1M4F4", "url": "https://omabrowser.org/oma/group/A0A3Q1M4F4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6IFU8-1", "protein_name": "Keratin, type I cytoskeletal 17", "gene_name": "Krt17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTTTIRQFTSSSSIKGSSGLGGGSSRTSCRLSGSLGAGSCRLGSASGLGSALGGNSYSSCYSFGTGSGYGGNFGGVDGLLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQKQAPGPARDYSAYYQTIEDLKNKILVATVDNASILLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILSEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGSLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKPKEPVTTRQVRTIVEEVQDGKVISSREQVHQTTR", "length": 433 }, "evidence": [ { "id": "A0A3Q1M4F4", "url": "https://omabrowser.org/oma/group/A0A3Q1M4F4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9QWL7-1", "protein_name": "Keratin, type I cytoskeletal 17", "gene_name": "Krt17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTTTIRQFTSSSSIKGSSGLGGGSSRTSCRLSGSLGAGSCRLGSASGLGSALGSNSYSSCYSFGTGSGYGGNFGGVDGLLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQKQAPGPARDYSAYYHTIEDLKNKILVATVDNASILLQIDNARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILSEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGSLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKPKEPVTTRQVRTIVEEVQDGKVISSREQVHQTTR", "length": 433 }, "evidence": [ { "id": "A0A3Q1M4F4", "url": "https://omabrowser.org/oma/group/A0A3Q1M4F4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "intermediate filament", "id": "GO:0005882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005882", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4F4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4F4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4F4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4" } ], "pmid": "" }, { "name": "cornified envelope", "id": "GO:0001533", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001533", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4F4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4" } ], "pmid": "" }, { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4F4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4F4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4" } ], "pmid": "" }, { "name": "structural constituent of skin epidermis", "id": "GO:0030280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030280", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4F4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "morphogenesis of an epithelium", "id": "GO:0002009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002009", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4F4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4F4" } ], "pmid": "" }, { "name": "cornea development in camera-type eye", "id": "GO:0061303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061303", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4F4", "url": 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"MATGLGEPVYGLSEEEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDIPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDEMEPGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDSNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGEGPEPWETISEEVNMSGDSLSLALPPPPASPVSRTSPQELSEELSRRLQVTPDSNGEQFGSLIQREPSSRLRSCSVTDAVAEQAHLPPLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD", "length": 911, "header": "tr|A0A3Q1LFY0-1|A0A3Q1M231_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase NEDD4-like OS=Bos taurus OX=9913 GN=NEDD4L PE=4 SV=2 CANONICAL=A0A3Q1M231-1" }, "locus": { "chromosome": "24", "start_pos": 57545984, "end_pos": 57163950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067021.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067021.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057192.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057192.2" } ] } }, { "isoform_ac": "A0A3Q1M231-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M231/entry", "sequence": { "sequence": "MPSGAEGQAGPAAAAPEPRRWSLQHVPDASGSSGKRCFVFQLQQPPAGGGGPAPSGDFNFGFTGTKGDRLVRYPRIRLERSSSYPTQPRAERGSPPEERGHPDPEAPPRGRRVAPDAHRTEAVAERSPQGQGCTFKIRQDQNAGQQHFRILVTRGPEEAPQSPEEDAAAAGPASTGAGAPTRDDFLGQVDIPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDEMEPGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDSNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGEGPEPWETISEEVNMSGDSLSLALPPPPASPVSRTSPQELSEELSRRLQVTPDSNGEQFGSLIQREPSSRLRSCSVTDAVAEQAHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD", "length": 1036, "header": "tr|A0A3Q1M231-1|A0A3Q1M231_BOVIN Isoform 1 of E3 ubiquitin-protein ligase NEDD4-like OS=Bos taurus OX=9913 GN=NEDD4L PE=4 SV=3 CANONICAL=A0A3Q1M231-1" }, "locus": { "chromosome": "24", "start_pos": 57545984, "end_pos": 57390700, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070128.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070128.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067434.3", "url": "https://www.ensembl.org/id/ENSBTAP00000067434.3" } ] } }, { "isoform_ac": "A0A3Q1MH88-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH88/entry", "sequence": { "sequence": "MEQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDIPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDEMEPGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDSNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGEGPEPWETISEEVNMSGDSLSLALPPPPASPVSRTSPQELSEELSRRLQVTPDSNGEQFGSLIQREPSSRLRSCSVTDAVAEQAHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD", "length": 942, "header": "tr|A0A3Q1MH88-1|A0A3Q1M231_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase NEDD4-like OS=Bos taurus OX=9913 GN=NEDD4L PE=4 SV=2 CANONICAL=A0A3Q1M231-1" }, "locus": { "chromosome": "24", "start_pos": 57545984, "end_pos": 57164994, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075611.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075611.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068427.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068427.2" } ] } }, { "isoform_ac": "A0A3Q1MHU5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHU5/entry", "sequence": { "sequence": "MATGLGEPVYGLSEEEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDIPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDEMEPGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDSNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGEGPEPWETISEEVNMSGDSLSLALPPPPASPVSRTSPQELSEELSRRLQVTPDSNGEQFGSLIQREPSSRLRSCSVTDAVAEQAHLPPGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD", "length": 871, "header": "tr|A0A3Q1MHU5-1|A0A3Q1M231_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase NEDD4-like OS=Bos taurus OX=9913 GN=NEDD4L PE=4 SV=2 CANONICAL=A0A3Q1M231-1" }, "locus": { "chromosome": "24", "start_pos": 57545984, "end_pos": 57163950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081981.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081981.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073858.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073858.2" } ] } }, { "isoform_ac": "A0A3Q1MJ08-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ08/entry", "sequence": { "sequence": "MATGLGEPVYGLSEEEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDIPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDEMEPGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDSNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGEGPEPWETISEEVNMSGDSLSLALPPPPASPVSRTSPQELSEELSRRLQVTPDSNGEQFGSLIQREPSSRLRSCSVTDAVAEQAHLPPPSAPAGRARSSTVTGGEAPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD", "length": 975, "header": "tr|A0A3Q1MJ08-1|A0A3Q1MJ08_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase NEDD4-like OS=Bos taurus OX=9913 GN=NEDD4L PE=4 SV=2 CANONICAL=A0A3Q1M231-1" }, "locus": { "chromosome": "24", "start_pos": 57545984, "end_pos": 57163950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074498.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074498.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071305.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071305.2" } ] } }, { "isoform_ac": "A0AAA9S4A9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4A9/entry", "sequence": { "sequence": "MATGLGEPVYGLSEEEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDIPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDEMEPGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDSNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGEGPEPWETISEEVNMSGDSLSLALPPPPASPVSRTSPQELSEELSRRLQVTPDSNGEQFGSLIQREPSSRLRSCSVTDAVAEQAHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD", "length": 863, "header": "tr|A0AAA9S4A9-1|A0A3Q1M231_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase NEDD4-like OS=Bos taurus OX=9913 GN=NEDD4L PE=4 SV=1 CANONICAL=A0A3Q1M231-1" }, "locus": { "chromosome": "24", "start_pos": 57545984, "end_pos": 57163950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105698.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105698.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076964.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076964.1" } ] } }, { "isoform_ac": "A0ABI0NKG6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKG6/entry", "sequence": { "sequence": "MNLEDNYSDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDIPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDEMEPGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDSNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGEGPEPWETISEEVNMSGDSLSLALPPPPASPVSRTSPQELSEELSRRLQVTPDSNGEQFGSLIQREPSSRLRSCSVTDAVAEQAHLPPPSAPAGRARSSTVTGGEAPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHT", "length": 908, "header": "tr|A0ABI0NKG6-1|A0ABI0NKG6_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase OS=Bos taurus OX=9913 GN=NEDD4L PE=4 SV=1 CANONICAL=A0A3Q1M231-1" }, "locus": { "chromosome": "24", "start_pos": 57538717, "end_pos": 57349290, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000137385.1", "url": "https://www.ensembl.org/id/ENSBTAT00000137385.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105192.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105192.1" } ] } }, { "isoform_ac": "A0ABI0P534-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P534/entry", "sequence": { "sequence": "MATGLGEPVYGLSEEEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDIPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDEMEPGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDSNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGEGPEPWETISEEVNMSGDSLSLALPPPPASPVSRTSPQELSEELSRRLQVTPDSNGEQFGSLIQREPSSRLRSCSVTDAVAEQAHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHT", "length": 921, "header": "tr|A0ABI0P534-1|A0ABI0P534_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase OS=Bos taurus OX=9913 GN=NEDD4L PE=4 SV=1 CANONICAL=A0A3Q1M231-1" }, "locus": { "chromosome": "24", "start_pos": 57538717, "end_pos": 57163950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136131.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136131.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106108.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106108.1" } ] } }, { "isoform_ac": "F1MJ09-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ09/entry", "sequence": { "sequence": "MNKSSTGPWQSDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDIPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDEMEPGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDSNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGEGPEPWETISEEVNMSGDSLSLALPPPPASPVSRTSPQELSEELSRRLQVTPDSNGEQFGSLIQREPSSRLRSCSVTDAVAEQAHLPPPSAPAGRARSSTVTGGEAPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD", "length": 945, "header": "tr|F1MJ09-1|F1MJ09_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase OS=Bos taurus OX=9913 GN=NEDD4L PE=4 SV=4 CANONICAL=A0A3Q1M231-1" }, "locus": { "chromosome": "24", "start_pos": 57545984, "end_pos": 57364512, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018334.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018334.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018334.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018334.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "sodium channel inhibitor activity", "id": "GO:0019871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019871", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M231", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M231" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M231", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M231" } ], "pmid": "" }, { "name": "potassium channel inhibitor activity", "id": "GO:0019870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019870", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M231", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M231" } ], "pmid": "" }, { "name": "transmembrane transporter binding", "id": "GO:0044325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M231", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M231" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M231", "url": 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"MLPFAPQDEPWDQEMEVFGGSASSVEVNGLKMVDDPMEEGEADSCQDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRIRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVDEIKRHLFFANIDWNKLYKREVQPPFKPASGKPDDAFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQVNGNAAQFGEVYELKEDIGVGSYSVCKRCIHTTTNMEFAVKIIDKIKRDPSEEIEILMRYGQHPNIITLKDVYDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDVLFIITKTVDYLHCQGVVHRDLKPSNILYMDESANADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDSISDGAKDLLSHMLHMDPQQRYTTEQVLKHSWITHRDQLPDDQPSRNGSSHVVKGAVVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL", "length": 744, "header": "tr|A0A3Q1M4X3-1|A0A3Q1M4X3_BOVIN Isoform 1 of Ribosomal protein S6 kinase OS=Bos taurus OX=9913 GN=RPS6KA6 PE=3 SV=1 CANONICAL=A0A3Q1M4X3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJN0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJN0/entry", "sequence": { "sequence": "MGLSTSAIWKNTGVEIVNPYEVKRKVKVNGLKMVDDPMEEGEADSCQDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRIRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVDEIKRHLFFANIDWNKLYKREVQPPFKPASGKPDDAFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQVNGNAAQFGEVYELKEDIGVGSYSVCKRCIHTTTNMEFAVKIIDKIKRDPSEEIEILMRYGQHPNIITLKDVYDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDVLFIITKTVDYLHCQGVVHRDLKPSNILYMDESANADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDSISDGAKGSGTSLLSSLWIVFQDLLSHMLHMDPQQRYTTEQVLKHSWITHRDQLPDDQPSRNGSSHVVKGAVVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL", "length": 760, "header": "tr|A0A3Q1LJN0-1|A0A3Q1M4X3_BOVIN Computationally mapped isoform of Ribosomal protein S6 kinase OS=Bos taurus OX=9913 GN=RPS6KA6 PE=3 SV=2 CANONICAL=A0A3Q1M4X3-1" }, "locus": { "chromosome": "X", "start_pos": 68685682, "end_pos": 68489918, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075096.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075096.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059659.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059659.2" } ] } }, { "isoform_ac": "A0A3Q1LXK8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXK8/entry", "sequence": { "sequence": "MEINWRQGFFIYTQVMFCSLLGGLLNSTALFRPFSLCPTAVPAPLVSERTGKVNSSPYKRNLWINEEGFVSSWNVSYLQEFSRRLLKGRGILFNLLCFRYYRDLTMGLSTSAIWKNTGVEIVNPYEVKRKVKVNGLKMVDDPMEEGEADSCQDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRIRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVDEIKRHLFFANIDWNKLYKREVQPPFKPASGKPDDAFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQVNGNAAQFGEVYELKEDIGVGSYSVCKRCIHTTTNMEFAVKIIDKIKRDPSEEIEILMRYGQHPNIITLKDVYDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDVLFIITKTVDYLHCQGVVHRDLKPSNILYMDESANADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDSISDGAKDLLSHMLHMDPQQRYTTEQVLKHSWITHRDQLPDDQPSRNGSSHVVKGAVVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL", "length": 850, "header": "tr|A0A3Q1LXK8-1|A0A3Q1LXK8_BOVIN Computationally mapped isoform of Ribosomal protein S6 kinase OS=Bos taurus OX=9913 GN=RPS6KA6 PE=3 SV=2 CANONICAL=A0A3Q1M4X3-1" }, "locus": { "chromosome": "X", "start_pos": 68685682, "end_pos": 68488799, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084963.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084963.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062237.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062237.2" } ] } }, { "isoform_ac": "A0A3Q1M4X3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3/entry", "sequence": { "sequence": "MLPFAPQDEPWDQEMEVFGGSASSVEVNGLKMVDDPMEEGEADSCQDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRIRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVDEIKRHLFFANIDWNKLYKREVQPPFKPASGKPDDAFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQVNGNAAQFGEVYELKEDIGVGSYSVCKRCIHTTTNMEFAVKIIDKIKRDPSEEIEILMRYGQHPNIITLKDVYDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDVLFIITKTVDYLHCQGVVHRDLKPSNILYMDESANADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDSISDGAKDLLSHMLHMDPQQRYTTEQVLKHSWITHRDQLPDDQPSRNGSSHVVKGAVVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL", "length": 744, "header": "tr|A0A3Q1M4X3-1|A0A3Q1M4X3_BOVIN Isoform 1 of Ribosomal protein S6 kinase OS=Bos taurus OX=9913 GN=RPS6KA6 PE=3 SV=1 CANONICAL=A0A3Q1M4X3-1" }, "locus": { "chromosome": "X", "start_pos": 68685682, "end_pos": 68488146, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072482.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072482.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064886.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064886.1" } ] } }, { "isoform_ac": "A0A3Q1M608-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M608/entry", "sequence": { "sequence": "MFLFLRCAKCASCQFEGQLLTPALYLNTGCFRNPAQQKQQKQQVCFRYYRDLTMGLSTSAIWKNTGVEIVNPYEVKRKVKVNGLKMVDDPMEEGEADSCQDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRIRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVDEIKRHLFFANIDWNKLYKREVQPPFKPASGKPDDAFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQVNGNAAQFGEVYELKEDIGVGSYSVCKRCIHTTTNMEFAVKIIDKIKRDPSEEIEILMRYGQHPNIITLKDVYDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDVLFIITKTVDYLHCQGVVHRDLKPSNILYMDESANADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDSISDGAKDLLSHMLHMDPQQRYTTEQVLKHSWITHRDQLPDDQPSRNGSSHVVKGAVVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL", "length": 798, "header": "tr|A0A3Q1M608-1|A0A3Q1M4X3_BOVIN Computationally mapped isoform of Ribosomal protein S6 kinase OS=Bos taurus OX=9913 GN=RPS6KA6 PE=3 SV=2 CANONICAL=A0A3Q1M4X3-1" }, "locus": { "chromosome": "X", "start_pos": 68685682, "end_pos": 68488571, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080892.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080892.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063716.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063716.2" } ] } }, { "isoform_ac": "A0A3Q1NFZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFZ3/entry", "sequence": { "sequence": "MLPFAPQDEPWDQEMEVFGGSASSVEDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRIRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVDEIKRHLFFANIDWNKLYKREVQPPFKPASGKPDDAFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQVNGNAAQFGEVYELKEDIGVGSYSVCKRCIHTTTNMEFAVKIIDKIKRDPSEEIEILMRYGQHPNIITLKDVYDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDVLFIITKTVDYLHCQGVVHRDLKPSNILYMDESANADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDSISDGAKDLLSHMLHMDPQQRYTTEQVLKHSWITHRDQLPDDQPSRNGSSHVVKGAVVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL", "length": 724, "header": "tr|A0A3Q1NFZ3-1|A0A3Q1M4X3_BOVIN Computationally mapped isoform of Ribosomal protein S6 kinase OS=Bos taurus OX=9913 GN=RPS6KA6 PE=3 SV=2 CANONICAL=A0A3Q1M4X3-1" }, "locus": { "chromosome": "X", "start_pos": 68685682, "end_pos": 68488146, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069521.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069521.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070657.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070657.2" } ] } }, { "isoform_ac": "A0ABI0P028-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P028/entry", "sequence": { "sequence": "MDKGRGEEGEGEDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRIRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVDEIKRHLFFANIDWNKLYKREVQPPFKPASGKPDDAFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQVNGNAAQFGEVYELKEDIGVGSYSVCKRCIHTTTNMEFAVKIIDKIKRDPSEEIEILMRYGQHPNIITLKDVYDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDVLFIITKTVDYLHCQGVVHRDLKPSNILYMDESANADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDSISDGAKDLLSHMLHMDPQQRYTTEQVLKHSWITHRDQLPDDQPSRNGSSHVVKGAVVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL", "length": 710, "header": "tr|A0ABI0P028-1|A0ABI0P028_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=RPS6KA6 PE=3 SV=1 CANONICAL=A0A3Q1M4X3-1" }, "locus": { "chromosome": "X", "start_pos": 68685682, "end_pos": 68549843, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000142226.1", "url": "https://www.ensembl.org/id/ENSBTAT00000142226.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104527.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104527.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:526227", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526227", "resource": "KEGG Pathway" }, { "id": "R-BTA-442742", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442742", "resource": "Reactome", "description": "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling" }, { "id": "R-BTA-444257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-444257", "resource": "Reactome", "description": "RSK activation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480L5M3-1", "protein_name": "Ribosomal protein S6 kinase", "gene_name": "RPS6KA6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLPFAPLDEPWEAEMEVFRGSASSGEVNGLKMVDEPMEEGEADSCQDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEIGHIKLTDFGLSKEAVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVDEIKRHLFFANIDWNKLYKREVHPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSTNVLPIVQVNGNAAQFGEMYELKEDIGVGSYSVCKRCIHSATSMEFAVKIIDKSKRDPSEEIEILMHYGQHPNIITLKDVYDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDVLFIITKTVDYLHCQGVVHRDLKPSNILYMDESANADSIKICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDSISDGAKDLLSHMLHMDPQQRYTTEQVLKHSWITHRDQLPNDQPNRNDTSQAVKGAMVATYSALTHNTFQPVLEPVAASSLAQRRSMKKRTSTGL", "length": 744 }, "evidence": [ { "id": "A0A3Q1M4X3", "url": "https://omabrowser.org/oma/group/A0A3Q1M4X3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YSH3-1", "protein_name": "Ribosomal protein S6 kinase", "gene_name": "RPS6KA6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVPCAPLEDVEEPEPCRKMELYVSGGELNGLKMADEPMEEGEPYSYHDEGSVKEIPITHHVKEGCEKADPAQFELLKVLGQGSFGKVFLVRKIIGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIVYRDLKPENILLDEAGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHNQSADWWSFGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSPEAQSLLRMLFKRNPSNRLGAGSDGVEEIKRHPFFSTVDWNKLFRREIQPPFKPASGKPEDTFCFDPEFTAKTPKDSPGVPPSANAHQLFKGFSFVATTAVEDHKISPLTNILPIVQQLHGNSAQFTDVYELKEDIGVGSYSVCKRCIHIATNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVYDDGRFIYLVTELMKGGELLDRILRQKFFSEREASAVLYTITKTVDYLHCQGVVHRDLKPSNILYTDDSNNADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMRQGYDAACDIWSLGVLLYTMLAGYTPFANGPNDTPEEILVRIGSGKFSLSGGNWDTVSDAAKDLLSHMLHVDPHQRYTAEQVLKHSWIACRDQLPHYQLNRQDAPHLVKGAMAATYSALNHKTFQPVLEPVAASSLAQRRSMKKLTSTDL", "length": 746 }, "evidence": [ { "id": "A0A3Q1M4X3", "url": "https://omabrowser.org/oma/group/A0A3Q1M4X3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9UK32-1", "protein_name": "Ribosomal protein S6 kinase alpha-6", "gene_name": "RPS6KA6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL", "length": 745 }, "evidence": [ { "id": "A0A3Q1M4X3", "url": "https://omabrowser.org/oma/group/A0A3Q1M4X3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ], "pmid": "" }, { "name": "protein serine kinase activity", "id": "GO:0106310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106310", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ], "pmid": "" }, { "name": "ribosomal protein S6 kinase activity", "id": "GO:0004711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004711", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ], "pmid": "" }, { "name": "DNA damage response, signal transduction by p53 class mediator", "id": "GO:0030330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030330", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ], "pmid": "" }, { "name": "TORC1 signaling", "id": "GO:0038202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038202", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M4X3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 626, "end_pos": 628, "annotation": "n_glycosylation_sequon" }, { "start_pos": 696, "end_pos": 698, "annotation": "n_glycosylation_sequon" } ], 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"A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "R-BTA-442724", "name": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M4X3-1", "A0A3Q1LYH3-1" ], "evidence": [ { "id": "R-BTA-442724", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442724" } ] }, { "id": "R-BTA-9029434", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M4X3-1", "A0A3Q1LYH3-1" ], "evidence": [ { "id": "R-BTA-9029434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9029434" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": 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{ "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": 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"ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": 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"A0A3Q1LYS5-1", "uniprot_ac": "A0A3Q1LYS5", "uniprot_id": "A0A3Q1LYS5_BOVIN", "mass": { "chemical_mass": 138687.0, "monoisotopic_mass": 138687.0 }, "refseq": {}, "gene_names": [ { "name": "ATP8B2", "type": "recommended", "evidence": [ { "id": "A0A3Q1LYS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ] } ], "protein_names": [ { "name": "Phospholipid-transporting ATPase", "type": "recommended", "evidence": [ { "id": "A0A3Q1LYS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.1", "type": "synonym", "evidence": [ { "id": "A0A3Q1LYS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATP8B2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5", "locus": { "chromosome": "3", "start_pos": 16210799, "end_pos": 16233030, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005161", "url": "https://www.ensembl.org/id/ENSBTAG00000005161" } ] } } ], "crossref": [ { "id": "A0A3Q1LYS5", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LYS5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005161", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005161", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02073", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02073", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "785713", "url": "https://www.ncbi.nlm.nih.gov/gene/785713", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001757", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001757", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008250", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008250", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018303", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018303", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785713", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785713", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M082", "url": "https://www.orthodb.org/?gene=A0A3Q1M082", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N4D5", "url": "https://www.orthodb.org/?gene=F1N4D5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24092", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24092:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24092:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13246", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13246", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16209", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16209", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16212", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16212", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-936837", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-936837", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LYS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYS5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M082", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M082", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M082-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M082-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4D5", "url": "https://www.uniprot.org/uniprotkb/F1N4D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N4D5-1", "url": "https://www.uniprot.org/uniprotkb/F1N4D5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VATFGAVPLLSISVLLSLCPSFPCKVSHGIAGTLLGEMALCAKKRPPEEERRARANDREYNEKFQYASNCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQVNNRQSQVLINGILQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSELGDISKLAKFDGEVICEPPNNKLDKFSGTLYWKESKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAIWEHEVGTRFQVYLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMFCTKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGRSYGDVFDVLGHKAELGERPEPVDFSFNPLADKKFLFWDPTLLEAVKMGDPHTHEFFRLLSLCHTVMSEEKSEGELYYKAQSPDEGALVTAARNFGFVFRSRTPKTITVHEMGTAITYQLLAILDFNNIRKRMSVIVRNPEGKIRLYCKGADTILLDRLHHSTQELLNTTTDHLNEYAGEGLRTLVLAYKDLDEEYYEEWAGRRLQASLAQDSRDDRLASVYEEVESDMMLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFIVTGHTVLEVREELRKAREKMMDSSRAVGNGFTYQEKLSSSRLTSVLEAVAGEYALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIPYGVFAEATRDDGTQLADYQSFAVTVATSLVIVVSVQIGLDTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVVCIMPVVAFRFLRLNLKPDLSDTVRYTQLVRKKQKAQHRCMRRVGRTGSRRSGYAFSHQEGFGELIMSGKNMRLSSLALSSFTTRSSSSWIESLRRKKSDSASSPSGGADKPLKG", "length": 1227, "header": "tr|A0A3Q1LYS5-1|A0A3Q1LYS5_BOVIN Isoform 1 of Phospholipid-transporting ATPase OS=Bos taurus OX=9913 GN=ATP8B2 PE=3 SV=1 CANONICAL=A0A3Q1LYS5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LYS5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5/entry", "sequence": { "sequence": "VATFGAVPLLSISVLLSLCPSFPCKVSHGIAGTLLGEMALCAKKRPPEEERRARANDREYNEKFQYASNCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQVNNRQSQVLINGILQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSELGDISKLAKFDGEVICEPPNNKLDKFSGTLYWKESKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAIWEHEVGTRFQVYLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMFCTKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGRSYGDVFDVLGHKAELGERPEPVDFSFNPLADKKFLFWDPTLLEAVKMGDPHTHEFFRLLSLCHTVMSEEKSEGELYYKAQSPDEGALVTAARNFGFVFRSRTPKTITVHEMGTAITYQLLAILDFNNIRKRMSVIVRNPEGKIRLYCKGADTILLDRLHHSTQELLNTTTDHLNEYAGEGLRTLVLAYKDLDEEYYEEWAGRRLQASLAQDSRDDRLASVYEEVESDMMLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFIVTGHTVLEVREELRKAREKMMDSSRAVGNGFTYQEKLSSSRLTSVLEAVAGEYALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIPYGVFAEATRDDGTQLADYQSFAVTVATSLVIVVSVQIGLDTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVVCIMPVVAFRFLRLNLKPDLSDTVRYTQLVRKKQKAQHRCMRRVGRTGSRRSGYAFSHQEGFGELIMSGKNMRLSSLALSSFTTRSSSSWIESLRRKKSDSASSPSGGADKPLKG", "length": 1227, "header": "tr|A0A3Q1LYS5-1|A0A3Q1LYS5_BOVIN Isoform 1 of Phospholipid-transporting ATPase OS=Bos taurus OX=9913 GN=ATP8B2 PE=3 SV=1 CANONICAL=A0A3Q1LYS5-1" }, "locus": { "chromosome": "3", "start_pos": 16230725, "end_pos": 16212543, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081817.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081817.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062432.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062432.2" } ] } }, { "isoform_ac": "A0A3Q1M082-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M082/entry", "sequence": { "sequence": "MALCAKKRPPAPVPPRGAAPSEPLRPRTDRQTARPPPAQTGVMTVPKEMPEKWARAGAPPSWSRKKPSWGTEEERRARANDREYNEKFQYASNCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQVNNRQSQVLINGILQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSELGDISKLAKFDGEVICEPPNNKLDKFSGTLYWKESKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAIWEHEVGTRFQVYLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMFCTKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGRSYGDVFDVLGHKAELGERPEPVDFSFNPLADKKFLFWDPTLLEAVKMGDPHTHEFFRLLSLCHTVMSEEKSEGELYYKAQSPDEGALVTAARNFGFVFRSRTPKTITVHEMGTAITYQLLAILDFNNIRKRMSVIVRNPEGKIRLYCKGADTILLDRLHHSTQELLNTTTDHLNEYAGEGLRTLVLAYKDLDEEYYEEWAGRRLQASLAQDSRDDRLASVYEEVESDMMLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFIVTGHTVLEVREELRKAREKMMDSSRAVGNGFTYQEKLSSSRLTSVLEAVAGEYALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIPYGVFAEATRDDGTQLADYQSFAVTVATSLVIVVSVQIGLDTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVVCIMPVVAFRFLRLNLKPDLSDTVRYTQLVRKKQKAQHRCMRRVGRTGSRRSGYAFSHQEGFGELIMSGKNMRLSSLALSSFTTRSSSSWIESLRRKKSDSASSPSGGADKPLKG", "length": 1251, "header": "tr|A0A3Q1M082-1|A0A3Q1M082_BOVIN Computationally mapped isoform of Phospholipid-transporting ATPase OS=Bos taurus OX=9913 GN=ATP8B2 PE=3 SV=2 CANONICAL=A0A3Q1LYS5-1" }, "locus": { "chromosome": "3", "start_pos": 16230375, "end_pos": 16212543, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075591.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075591.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061367.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061367.2" } ] } }, { "isoform_ac": "A0AAA9RXK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXK9/entry", "sequence": { "sequence": "MALCAKKRPPEEERRARANDREYNEKFQYASNCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQVNNRQSQVLINGILQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSELGDISKLAKFDGEVICEPPNNKLDKFSGTLYWKESKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAIWEHEVGTRFQVYLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVRYAVSLPRGLSRESGGPLGLLSSVKVKSSRGNLGSSPSCAVNIL", "length": 388, "header": "tr|A0AAA9RXK9-1|A0A3Q1LYS5_BOVIN Computationally mapped isoform of Phospholipid-transporting ATPase OS=Bos taurus OX=9913 GN=ATP8B2 PE=3 SV=1 CANONICAL=A0A3Q1LYS5-1" }, "locus": { "chromosome": "3", "start_pos": 16230375, "end_pos": 16222405, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107011.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107011.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075887.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075887.1" } ] } }, { "isoform_ac": "F1N4D5-1", "url": "https://www.uniprot.org/uniprotkb/F1N4D5/entry", "sequence": { "sequence": "MALCAKKRPPEEERRARANDREYNEKFQYASNCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQVNNRQSQVLINGILQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSELGDISKLAKFDGEVICEPPNNKLDKFSGTLYWKESKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAIWEHEVGTRFQVYLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMFCTKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGRSYGDVFDVLGHKAELGERPEPVDFSFNPLADKKFLFWDPTLLEAVKMGDPHTHEFFRLLSLCHTVMSEEKSEGELYYKAQSPDEGALVTAARNFGFVFRSRTPKTITVHEMGTAITYQLLAILDFNNIRKRMSVIVRNPEGKIRLYCKGADTILLDRLHHSTQELLNTTTDHLNEYAGEGLRTLVLAYKDLDEEYYEEWAGRRLQASLAQDSRDDRLASVYEEVESDMMLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFIVTGHTVLEVREELRKAREKMMDSSRAVGNGFTYQEKLSSSRLTSVLEAVAGEYALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIPYGVFAEATRDDGTQLADYQSFAVTVATSLVIVVSVQIGLDTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVVCIMPVVAFRFLRLNLKPDLSDTVRYTQLVRKKQKAQHRCMRRVGRTGSRRSGYAFSHQEGFGELIMSGKNMRLSSLALSSFTTRSSSSWIESLRRKKSDSASSPSGGADKPLKG", "length": 1190, "header": "tr|F1N4D5-1|A0A3Q1LYS5_BOVIN Computationally mapped isoform of Phospholipid-transporting ATPase OS=Bos taurus OX=9913 GN=ATP8B2 PE=3 SV=3 CANONICAL=A0A3Q1LYS5-1" }, "locus": { "chromosome": "3", "start_pos": 16230375, "end_pos": 16212543, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033991.6", "url": "https://www.ensembl.org/id/ENSBTAT00000033991.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033893.5", "url": "https://www.ensembl.org/id/ENSBTAP00000033893.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1033, "start_aa": "Thr", "end_pos": 1033, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1033", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:785713", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785713", "resource": "KEGG Pathway" }, { "id": "R-BTA-936837", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-936837", "resource": "Reactome", "description": "Ion transport by P-type ATPases" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ], "pmid": "" }, { "name": "phosphatidylcholine flippase activity", "id": "GO:0140345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140345", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ], "pmid": "" }, { "name": "ATPase-coupled intramembrane lipid transporter activity", "id": "GO:0140326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140326", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "phospholipid translocation", "id": "GO:0045332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045332", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ], "pmid": "" }, { "name": "Golgi organization", "id": "GO:0007030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LYS5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 616, "end_pos": 618, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-939763", "name": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4J6-1", "A0AAA9T7P4-1", "F1MMX5-1", "A0AAA9SGU3-1", "A0AAA9RSX8-1", "A0AAA9SM02-1", "A0A3Q1LQH9-1", "A0A3Q1M9T8-1", "A0A3Q1LM90-1", "E1BPC3-1", "A0A3Q1LYS5-1", "A0A3Q1M6H4-1", "A0A3Q1MTS5-1" ], "evidence": [ { "id": "R-BTA-939763", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-939763" } ] }, { "id": "R-BTA-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4J6-1", "A0AAA9T7P4-1", "F1MMX5-1", "A0AAA9SGU3-1", "A0AAA9RSX8-1", "A0AAA9SM02-1", "A0A3Q1LQH9-1", "A0A3Q1M9T8-1", "A0A3Q1LM90-1", "E1BPC3-1", "A0A3Q1LYS5-1", "A0A3Q1M6H4-1", "A0A3Q1MTS5-1" ], "evidence": [ { "id": "R-BTA-947591", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-947591" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LM90", "gene_name": "ATP11B", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A3Q1LM90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM90" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A3Q1LM90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM90" } ] } ] }, { "uniprot_ac": "A0A3Q1LQH9", "gene_name": "ATP10B", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A3Q1LQH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQH9" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQH9" } ] } ] }, { "uniprot_ac": "A0A3Q1LYS5", "gene_name": "ATP8B2", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A3Q1LYS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" } ] } ] }, { "uniprot_ac": "A0A3Q1M6H4", "gene_name": "ATP10D", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A3Q1M6H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6H4" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6H4" } ] } ] }, { "uniprot_ac": "A0A3Q1M9T8", "gene_name": "ATP11A", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A3Q1M9T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9T8" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9T8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9T8" } ] } ] }, { "uniprot_ac": "A0A3Q1MTS5", "gene_name": "ATP9A", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0A3Q1MTS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTS5" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0A3Q1MTS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTS5" } ] } ] }, { "uniprot_ac": "A0AAA9RSX8", "gene_name": "ATP11C", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0AAA9RSX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSX8" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0AAA9RSX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSX8" } ] } ] }, { "uniprot_ac": "A0AAA9SGU3", "gene_name": "ATP10A", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0AAA9SGU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU3" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0AAA9SGU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGU3" } ] } ] }, { "uniprot_ac": "A0AAA9SM02", "gene_name": "ATP8A2", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0AAA9SM02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM02" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0AAA9SM02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SM02" } ] } ] }, { "uniprot_ac": "A0AAA9T7P4", "gene_name": "ATP8B3", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A0AAA9T7P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7P4" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A0AAA9T7P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7P4" } ] } ] }, { "uniprot_ac": "A1A4J6", "gene_name": "ATP9B", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "A1A4J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4J6" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "A1A4J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4J6" } ] } ] }, { "uniprot_ac": "E1BPC3", "gene_name": "ATP8B1", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "E1BPC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPC3" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "E1BPC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPC3" } ] } ] }, { "uniprot_ac": "F1MMX5", "gene_name": "ATP8B4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MMX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMX5" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MMX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMX5" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LYS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" }, { "id": "PF16212", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16212" } ], "ann_type": "Domain_Extent_Annotation", 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"start_aa": "Tyr", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR606539-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606539-3" } ], "binding_site_uniprot": 394, "amino_acid": "Ile", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 394, "end_pos": 394, "start_aa": "Ile", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "A0A3Q1LYS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" }, { "id": "PIRSR606539-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606539-3" } ], "binding_site_uniprot": 429, "amino_acid": "Asp", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 429, "end_pos": 429, "start_aa": "Asp", "end_aa": 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{ "evidence": [ { "id": "PIRSR606539-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606539-3" } ], "binding_site_uniprot": 455, "amino_acid": "Phe", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 455, "end_pos": 455, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR606539-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606539-3" } ], "binding_site_uniprot": 814, "amino_acid": "Thr", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 814, "end_pos": 814, "start_aa": "Thr", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR606539-3", "database": "PIR Site Rule", "url": 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"https://www.uniprot.org/uniprotkb/A0A3Q1LYS5" }, { "id": "PIRSR606539-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606539-3" } ], "binding_site_uniprot": 855, "amino_acid": "Asp", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 855, "end_pos": 855, "start_aa": "Asp", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR606539-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606539-3" } ], "binding_site_uniprot": 875, "amino_acid": "Gln", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 875, "end_pos": 875, "start_aa": "Gln", "end_aa": "Gln", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR606539-3", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR606539-3" } ], "binding_site_uniprot": 879, "amino_acid": "Ala", "chebi_lig_id": "CHEBI:18420", "ligand": "Mg(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 879, "end_pos": 879, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "7.6.2.1", "ec_name": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "7.6.2.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=7.6.2.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1033 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 616, "end_pos": 618 } ] }, "class_list": [], "section_stats": [ { "table_id": 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{ "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "A0A3Q1LZ70-1", "uniprot_ac": "A0A3Q1LZ70", "uniprot_id": "A0A3Q1LZ70_BOVIN", "mass": { "chemical_mass": 115205.0, "monoisotopic_mass": 115205.0 }, "refseq": {}, "gene_names": [ { "name": "FAN1", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZ70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70" } ] } ], "protein_names": [ { "name": "Fanconi-associated nuclease", "type": "recommended", "evidence": [ { "id": "A0A3Q1LZ70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70/entry#names_and_taxonomy" } ] }, { "name": "3.1.4.1", "type": "synonym", "evidence": [ { "id": "A0A3Q1LZ70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MGR3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR3#function" }, { "database": "UniProtKB", "id": "RU365033", "url": "https://www.uniprot.org/uniprotkb/RU365033#function" }, { "database": "UniProtKB", "id": "A0A3Q1LZ70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70#function" }, { "database": "UniProtKB", "id": "F1MZ88", "url": "https://www.uniprot.org/uniprotkb/F1MZ88#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAN1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70", "locus": { "chromosome": "21", "start_pos": 27484809, "end_pos": 27412439, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009855", "url": "https://www.ensembl.org/id/ENSBTAG00000009855" } ] } } ], "crossref": [ { "id": "A0A3Q1LZ70", "url": "https://alphafold.ebi.ac.uk/entry/A0A3Q1LZ70", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009855", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009855", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22326", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22326", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508171", "url": "https://www.ncbi.nlm.nih.gov/gene/508171", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006642", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006642", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049132", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049132", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049138", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049138", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MZ88", "url": "https://www.orthodb.org/?gene=F1MZ88", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15749", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15749", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15749:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15749:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08774", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08774", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21170", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21170", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21315", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21315", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LZ70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ70-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGR3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGR3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZ88", "url": "https://www.uniprot.org/uniprotkb/F1MZ88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MZ88-1", "url": "https://www.uniprot.org/uniprotkb/F1MZ88-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMSVGKSSKKRPRTSLSSSKTKKNESNSIISFFNNAPPAKLACPVCSKMVPRYDLNRHLDEMCADHDDVTPGGPRHVSLSSNVPTIDLTNIALEDITPERSSPSTINLTPGQSDSAKMGKKQQTSPYFKSKGDSVCRNQDELRHHNVKVISLGSLSSKLSRRYIKAKRSLNQNEEFTNQSLQRSSCTRVKSLVDQHLEVEGQDALLENSSQKENVFTGDSQEELSAPAHTVEGTKVEEAEGQTAAQECEQSALTPTCTGDAPLLFSSDLILGHRKPASEDHLAKQESIKGVDGEVTEKCETGHSEEVKMTIVSEVTNQGSHREAKPPSSTLGASIQTNSQTLPSEPDSGLEDEITHQMPLEKRSSCDVSWVTSPELPDHPYYLRSFLVVLKAVFENEEDRMLFDEHEKGIVTKFHQLSANGQKLYVRLFQRKFSWIKVNKLDYEEISADLTPVVGELTHAGFLQTESELQELPEVLELLSAPELKALAKTFHLASAHGQKQQLVDAFLRLAKQPSVCTWGRNQPGIGAVILKRAKDVAGRSLRVSRGPRAVFSRALLLFSLSDMVEDEEAACGGQGQLSTVLLVNLGRLEFPRYTVNRKTLIFQDRDDLIRYAVAAHTLNDISTAMASGAWEEARELARCAKQDWDGLKDHPSLRYHENLPLFLRCFTVGWVYTRILSRNVEILQRLHLYEEAVKELENLLSQDVYCSDSRGRWWDRLALNLHQHLKRLEPAVQCIAAGLADPHVRTGHRLALYQRAARLRASPSGQKYMHLLRQLPEVTVEDVRHVTVTGRLCPQRGSGKSVFVLEAGGASPATVLCSVEELALAHYRHCGFDQGIHGEGSTFSTLFGLLLWDIIFMDGVPDAFRNAYQAAPLDLCTDSFFESRASAMEARLQQIHSAPEESLRAWVAAVWQAQEGRVSSLVSWDRFSSLQQAQDLVSCLGGSILSGVCRRLAMDFRHCRGGLPDLVVWSSQSHHVKIAHRGEGEGGREEVRRAWGIVWAAGTEVQPAWGQLGAGGWHGATPGLSQRSAQDIHLIGQQ", "length": 1039, "header": "tr|A0A3Q1LZ70-1|A0A3Q1LZ70_BOVIN Isoform 1 of Fanconi-associated nuclease OS=Bos taurus OX=9913 GN=FAN1 PE=3 SV=2 CANONICAL=A0A3Q1LZ70-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZ70-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70/entry", "sequence": { "sequence": "MMSVGKSSKKRPRTSLSSSKTKKNESNSIISFFNNAPPAKLACPVCSKMVPRYDLNRHLDEMCADHDDVTPGGPRHVSLSSNVPTIDLTNIALEDITPERSSPSTINLTPGQSDSAKMGKKQQTSPYFKSKGDSVCRNQDELRHHNVKVISLGSLSSKLSRRYIKAKRSLNQNEEFTNQSLQRSSCTRVKSLVDQHLEVEGQDALLENSSQKENVFTGDSQEELSAPAHTVEGTKVEEAEGQTAAQECEQSALTPTCTGDAPLLFSSDLILGHRKPASEDHLAKQESIKGVDGEVTEKCETGHSEEVKMTIVSEVTNQGSHREAKPPSSTLGASIQTNSQTLPSEPDSGLEDEITHQMPLEKRSSCDVSWVTSPELPDHPYYLRSFLVVLKAVFENEEDRMLFDEHEKGIVTKFHQLSANGQKLYVRLFQRKFSWIKVNKLDYEEISADLTPVVGELTHAGFLQTESELQELPEVLELLSAPELKALAKTFHLASAHGQKQQLVDAFLRLAKQPSVCTWGRNQPGIGAVILKRAKDVAGRSLRVSRGPRAVFSRALLLFSLSDMVEDEEAACGGQGQLSTVLLVNLGRLEFPRYTVNRKTLIFQDRDDLIRYAVAAHTLNDISTAMASGAWEEARELARCAKQDWDGLKDHPSLRYHENLPLFLRCFTVGWVYTRILSRNVEILQRLHLYEEAVKELENLLSQDVYCSDSRGRWWDRLALNLHQHLKRLEPAVQCIAAGLADPHVRTGHRLALYQRAARLRASPSGQKYMHLLRQLPEVTVEDVRHVTVTGRLCPQRGSGKSVFVLEAGGASPATVLCSVEELALAHYRHCGFDQGIHGEGSTFSTLFGLLLWDIIFMDGVPDAFRNAYQAAPLDLCTDSFFESRASAMEARLQQIHSAPEESLRAWVAAVWQAQEGRVSSLVSWDRFSSLQQAQDLVSCLGGSILSGVCRRLAMDFRHCRGGLPDLVVWSSQSHHVKIAHRGEGEGGREEVRRAWGIVWAAGTEVQPAWGQLGAGGWHGATPGLSQRSAQDIHLIGQQ", "length": 1039, "header": "tr|A0A3Q1LZ70-1|A0A3Q1LZ70_BOVIN Isoform 1 of Fanconi-associated nuclease OS=Bos taurus OX=9913 GN=FAN1 PE=3 SV=2 CANONICAL=A0A3Q1LZ70-1" }, "locus": { "chromosome": "21", "start_pos": 27438915, "end_pos": 27413335, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086891.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086891.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062609.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062609.2" } ] } }, { "isoform_ac": "A0A3Q1MGR3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR3/entry", "sequence": { "sequence": "MMSVGKSSKKRPRTSLSSSKTKKNESNSIISFFNNAPPAKLACPVCSKMVPRYDLNRHLDEMCADHDDVTPGGPRHVSLSSNVPTIDLTNIALEDITPERSSPSTINLTPGQSDSAKMGKKQQTSPYFKSKGDSVCRNQDELRHHNVKVISLGSLSSKLSRRYIKAKRSLNQNEEFTNQSLQRSSCTRVKSLVDQHLEVEGQDALLENSSQKENVFTGDSQEELSAPAHTVEGTKVEEAEGQTAAQECEQSALTPTCTGDAPLLFSSDLILGHRKPASEDHLAKQESIKGVDGEVTEKCETGHSEEVKMTIVSEVTNQGSHREAKPPSSTLGASIQTNSQTLPSEPDSGLEDEITHQMPLEKRSSCDVSWVTSPELPDHPYYLRSFLVVLKAVFENEEDRMLFDEHEKGIVTKFHQLSANGQKLYVRLFQRKFSWIKVNKLDYEEISADLTPVVGELTHAGFLQTESELQELPEVLELLSAPELKALAKTFHLASAHGQKQQLVDAFLRLAKQPSVCTWGRNQPGIGAVILKRAKDVAGRSLRVSRGPRAVFSRALLLFSLSDMVEDEEAACGGQGQLSTVLLVNLGRLEFPRYTVNRKTLIFQDRDDLIRYAVAAHTLNDISTAMASGAWEEARELARCAKQDWDGLKDHPSLRYHENLPLFLRCFTVGWVYTRILSRNVEILQRLHLYEEAVKELENLLSQDVYCSDSRGRWWDRLALNLHQHLKRLEPAVQCIAAGLADPHVRTGHRLALYQRAARLRASPSGQKYMHLLRQLPEVTVEDVRHVTVTGRLCPQRGSGKSVFVLEAGGASPATVLCSVEELALAHYRHCGFDQGIHGEGSTFSTLFGLLLWDIIFMDGVPDAFRNAYQAAPLDLCTDSFFESRASAMEARLQQIHSAPEESLRAWVAAVWQAQEGRVSSLVSWDRFSSLQQAQDLVSCLGGSILSGVCRRLAMDFRHCRGGLPDLVVWSSQSHHVKNLSPHDDGVLPCAR", "length": 992, "header": "tr|A0A3Q1MGR3-1|A0A3Q1LZ70_BOVIN Computationally mapped isoform of Fanconi-associated nuclease OS=Bos taurus OX=9913 GN=FAN1 PE=3 SV=1 CANONICAL=A0A3Q1LZ70-1" }, "locus": { "chromosome": "21", "start_pos": 27442484, "end_pos": 27413335, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080475.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080475.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068227.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068227.2" } ] } }, { "isoform_ac": "F1MZ88-1", "url": "https://www.uniprot.org/uniprotkb/F1MZ88/entry", "sequence": { "sequence": "MMSVGKSSKKRPRTSLSSSKTKKNESNSIISFFNNAPPAKLACPVCSKMVPRYDLNRHLDEMCADHDDVTPGGPRHVSLSSNVPTIDLTNIALEDITPERSSPSTINLTPGQSDSAKMGKKQQTSPYFKSKGDSVCRNQDELRHHNVKVISLGSLSSKLSRRYIKAKRSLNQNEEFTNQSLQRSSCTRVKSLVDQHLEVEGQDALLENSSQKENVFTGDSQEELSAPAHTVEGTKVEEAEGQTAAQECEQSALTPTCTGDAPLLFSSDLILGHRKPASEDHLAKQESIKGVDGEVTEKCETGHSEEVKMTIVSEVTNQGSHREAKPPSSTLGASIQTNSQTLPSEPDSGLEDEITHQMPLEKRSSCDVSWVTSPELPDHPYYLRSFLVVLKAVFENEEDRMLFDEHEKGIVTKFHQLSANGQKLYVRLFQRKFSWIKVNKLDYEEISADLTPVVGELTHAGFLQTESELQELPEVLELLSAPELKALAKTFHLASAHGQKQQLVDAFLRLAKQPSVCTWGRNQPGIGAVILKRAKDVAGRSLRVSRGPRAVFSRALLLFSLSDMVEDEEAACGGQGQLSTVLLVNLGRLEFPRYTVNRKTLIFQDRDDLIRYAVAAHTLNDISTAMASGAWEEARELARCAKQDWDGLKDHPSLRYHENLPLFLRCFTVGWVYTRILSRNVEILQRLHLYEEAVKELENLLSQDVYCSDSRGRWWDRLALNLHQHLKRLEPAVQCIAAGLADPHVRTGHRLALYQRAARLRASPSGQKYMHLLRQLPEVTVEDVRHVTVTGRLCPQRGSGKSVFVLEAGGASPATVLCSVEELALAHYRHCGFDQGIHGEGSTFSTLFGLLLWDIIFMDGVPDAFRNAYQVTLATFRLQSLCTHTRPRWTSAQTVSSRAGHQPWKPGCSRSTAPPRRACGPGWQLCGRPRKAGCPPWSAGIASLLCSKPRILCPAWGAPSSVACAAAWPWTSGTAEGASLTWLCGAPRVITSSWWK", "length": 996, "header": "tr|F1MZ88-1|F1MZ88_BOVIN Computationally mapped isoform of Fanconi-associated nuclease OS=Bos taurus OX=9913 GN=FAN1 PE=3 SV=3 CANONICAL=A0A3Q1LZ70-1" }, "locus": { "chromosome": "21", "start_pos": 27434842, "end_pos": 27413335, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000035195.5", "url": "https://www.ensembl.org/id/ENSBTAT00000035195.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000035073.4", "url": "https://www.ensembl.org/id/ENSBTAP00000035073.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70" } ], "pmid": "" }, { "name": "phosphodiesterase I activity", "id": "GO:0004528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004528", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70" } ], "pmid": "" }, { "name": "5'-3' exonuclease activity", "id": "GO:0008409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008409", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "interstrand cross-link repair", "id": "GO:0036297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036297", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LZ70", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "A0A3Q1LZ70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ70" }, { "id": "PS51908", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51908" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBZ4-type", "eco_id": "ECO_0000259", "start_pos": 40, "end_pos": 68, "start_aa": "Lys", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.4.1", "ec_name": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.", "evidence": [ { "id": "3.1.4.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.4.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 }, { "start_pos": 178, "end_pos": 180 }, { "start_pos": 208, "end_pos": 210 }, { "start_pos": 24, "end_pos": 26 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPB1-1", "uniprot_ac": "E1BPB1", "uniprot_id": "E1BPB1_BOVIN", "mass": { "chemical_mass": 150924.0, "monoisotopic_mass": 150924.0 }, "refseq": { "ac": "NP_001180158", "name": "kinesin-like protein KIF24", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180158" }, "gene_names": [ { "name": "KIF24", "type": "recommended", "evidence": [ { "id": "E1BPB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB1" } ] }, { "name": "KIF24", "type": "synonym", "evidence": [ { "id": "NP_001180158", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180158" } ] } ], "protein_names": [ { "name": "Kinesin-like protein KIF24", "type": "recommended", "evidence": [ { "id": "E1BPB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB1/entry#names_and_taxonomy" } ] }, { "name": "kinesin-like protein KIF24", "type": "synonym", "evidence": [ { "id": "NP_001180158", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180158" } ] } ], "function": [ { "annotation": "Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle. Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole.", "evidence": [ { "database": "UniProtKB", "id": "E1BPB1", "url": "https://www.uniprot.org/uniprotkb/E1BPB1#function" }, { "database": "UniProtKB", "id": "ARBA00057466", "url": "https://www.uniprot.org/uniprotkb/ARBA00057466#function" }, { "database": "UniProtKB", "id": "A0AAA9S0T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0T6#function" }, { "database": "UniProtKB", "id": "A0AAA9T652", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T652#function" }, { "database": "UniProtKB", "id": "A0A3Q1NF41", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NF41#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPB1", "url": "https://www.uniprot.org/uniprotkb/E1BPB1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIF24", "url": "https://www.uniprot.org/uniprotkb/E1BPB1", "locus": { "chromosome": "8", "start_pos": 75651802, "end_pos": 75724191, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012921", "url": "https://www.ensembl.org/id/ENSBTAG00000012921" } ] } } ], "crossref": [ { "id": "ENSBTAG00000012921", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012921", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01367", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01367", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09541", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09541", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513392", "url": "https://www.ncbi.nlm.nih.gov/gene/513392", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513392", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513392", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NF41", "url": "https://www.orthodb.org/?gene=A0A3Q1NF41", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BPB1", "url": "https://www.orthodb.org/?gene=E1BPB1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47971", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47971", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47971:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47971:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00225", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00225", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001180158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180158", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NF41", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NF41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NF41-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NF41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0T6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0T6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0T6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0T6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T652", "url": 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPB1", "url": "https://www.uniprot.org/uniprotkb/E1BPB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPB1-1", "url": "https://www.uniprot.org/uniprotkb/E1BPB1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSWLYECLYEAELAQYYPHFTALGLQKIDELANVTMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSSPDSRLQTSNLCVKPQKSRSGPRRQLHFDSPADNKDRTTSNNQFELCDLSDFSASEQKSNYIKVLEHMLPDDSQYHTQTGILNAAAAHSNIQKAAKISPFSSNHFSPVQGDCDSSVIQRVSHVSGYNYGIPHSYIRQNTSEKENPWTEMEKIRVCVRKRPLGMREVRRGEINIITVKDKETLLVHEKKEAVDLTQYILQHVFYFDEIFDEACTNQDIYMKTTHPLIQHIFNGGNATCFSYGQTGAGKTYTMIGTHQNPGLYALAARDIFRQLEVSQPRRHLFVWISFYEIYCGQLYDLLNRRKRLFAREDSKHVVQIVGLRELQVDSVELLLEVILKGSKERSTRATGVNADSSRSHAIIQIQIKDSAKRTFGRISFIDLAGSERAADARDSDRQTKMEGAEINQSLLALKECIRALDQEHTHTPFRQSKLTQVLKDSFIGNAKTCMIANISPSHVATEHTLNTLRYADRVKELKKGIKCCTPANSRNRTSGNSSNASPKRIQSSPVALPGDKYSPKKVKLGLQQPLTVPSGSMRGKAHPLASHPANIPFASVPKVPGREGGSQGSPPREWVIQTSSSKGTMLSGHVAIKRAEESAALCSEKNPIGNKTPLGWGSRAPGPGGDLVRGKPPSRCKRVQTVQPVQKQLVSRGELSFGSAQRLVEYGQGSKVGALSWPASEAWTNNIPVQQEAREEHLRFYHQQFQQPPLLQQKLQYQPLERFLCRSRPPEGQLQSDILPPFHPHRAESQDGAQVPQAEDPDDSDFSEDSFSHASCQRTTKQGKSPENSEGSFFLHQREQGPEEQVAERQQSLFFSPDGDEEGVTRSWVYSRDPAGHRRIALDHGHSPGQVPLDWSGEEDLDSSGPSPREDLAGKSYCAQVDSVYDRERGGGPAFDLRQEAFRSEVPGQAEGSLPSLEDDGFTCSLFHIAVPGSPDQRDTVSTPLREVSEDSPILETRTMKNSNPFQGDDSKGELGTCSEYASGLMAPLTMSLLESLDDGGAPSWEQPAQAGTAHGLVAVDTEGPAMGHTVSSGDPEAVLPTSSATEHLWLSSSPPDDKPGGSLPALSPSPIRQRPPDELPSGEADPGEACQSRGTTLFSRGHRDANAETELDGSQGFLGKPFLTLHPGGPHAGPTLTPRAGNSDVADQPRAQERKQPTGPSWPELGFSTDPITLSCYKEDIAWLKHRPIPRSLARPGSPLAASCSPETAGTLRQPALGHAQQVVIQAHQEQLDEMAELGFKEETLMSQLAPTDFEGFVIQLDEIMVLKSKCIQSLRSQLQLYLACHKPAAGPKRTAVS", "length": 1368, "header": "tr|E1BPB1-1|E1BPB1_BOVIN Isoform 1 of Kinesin-like protein KIF24 OS=Bos taurus OX=9913 GN=KIF24 PE=3 SV=3 CANONICAL=E1BPB1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NF41-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NF41/entry", "sequence": { "sequence": "MTSWLYECLYEAELAQYYPHFTALGLQKIDELANVTMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSSPDSRLQTSNLCVKPQKSRSGPRRQLHFDSPADNKDRTTSNNQFELCDLSDFSASEQKSNYIKVLEHMLPDDSQYHTQTGILNAAAAHSNIQKAAKISPFSSNHFSPVQGDCDSSVIQRVSHVSGYNYGIPHSYIRSQSFRTLRNSLTNLKLPVSESSLSEEHSLWIPQIRQNTSEKENPWTEMEKIRVCVRKRPLGMREVRRGEINIITVKDKETLLVHEKKEAVDLTQYILQHVFYFDEIFDEACTNQDIYMKTTHPLIQHIFNGGNATCFSYGQTGAGKTYTMIGTHQNPGLYALAARDIFRQLEVSQPRRHLFVWISFYEIYCGQLYDLLNRRKRLFAREDSKHVVQIVGLRELQVDSVELLLEKSPYGFYFQVILKGSKERSTRATGVNADSSRSHAIIQIQIKDSAKRTFGRISFIDLAGSERAADARDSDRQTKMEGAEINQSLLALKECIRALDQEHTHTPFRQSKLTQVLKDSFIGNAKTCMIANISPSHVATEHTLNTLRYADRVKELKKGIKCCTPANSRNRTSGNSSNASPKRIQSSPVALPGDKYSPKKVKLGLQQPLTVPSGSMRGKAHPLASHPANIPFASVPKVPGREGGSQGSPPREWVIQTSSSKGTMLSGHVAIKRAEESAALCSEKNPIGNKTPLGWGSRAPGPGGDLVRGKPPSRCKRVQTVQPVQKQLVSRGELSFGSAQRLVEYGQGSKVGALSWPASEAWTNNIPVQQEAREEHLRFYHQQFQQPPLLQQKLQYQPLERFLCRSRPPEGQLQSDILPPFHPHRAESQDGAQVPQAEDPDDSDFSEDSFSHASCQRTTKQGKSPENSEGSFFLHQREQGPEEQVAERQQSLFFSPDGDEEGVTRSWVYSRDPAGHRRIALDHGHSPGQVPLDWSGEEDLDSSGPSPREDLAGKSYCAQVDSVYDRERGGGPAFDLRQEAFRSEVPGQAEGSLPSLEDDGFTCSLFHIAVPGSPDQRDTVSTPLREVSEDSPILETRTMKNSNPFQGDDSKGELGTCSEYASGLMAPLTMSLLESLDDGGAPSWEQPAQAGTAHGLVAVDTEGPAMGHTVSSGDPEAVLPTSSATEHLWLSSSPPDDKPGGSLPALSPSPIRQRPPDELPSGEADPGEACQSRGTTLFSRGHRDANAETELDGSQGFLGKPFLTLHPGGPHAGPTLTPRAGNSDVADQPRAQERKQPTGPSWPELGFSTDPITLSCYKEDIAWLKHRPIPRSLARPGSPLAASCSPETAGTLRQPALGHAQQVVIQAHQEQLDEMAELGFKEETLMSQLAPTDFEGFVIQLDEIMVLKSKCIQSLRSQLQLYLACHKPAAGPKRTAVS", "length": 1412, "header": "tr|A0A3Q1NF41-1|A0A3Q1NF41_BOVIN Computationally mapped isoform of Kinesin-like protein KIF24 OS=Bos taurus OX=9913 GN=KIF24 PE=3 SV=2 CANONICAL=E1BPB1-1" }, "locus": { "chromosome": "8", "start_pos": 75700606, "end_pos": 75652385, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068576.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068576.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070287.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070287.2" } ] } }, { "isoform_ac": "A0AAA9S0T6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0T6/entry", "sequence": { "sequence": "MTSWLYECLYEAELAQYYPHFTALGLQKIDELANVTMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSSPDSRLQTSNLCVKPQKSRSGPRRQLHFDSPADNKDRTTSNNQFELCDLSDFSASEQKSNYIKVLEHMLPDDSQYHTQTGILNAAAAHSNIQKAAKISPFSSNHFSPVQGDCDSSVIQRVSHVSGYNYGIPHSYISRSQSFRTLRNSLTNLKLPVSESSLSEEHSLWIPQIRQNTSEKENPWTEMEKIRVCVRKRPLGMREVRRGEINIITVKDKETLLVHEKKEAVDLTQYILQHVFYFDEIFDEACTNQDIYMKTTHPLIQHIFNGGNATCFSYGQTGAGKTYTMIGTHQNPGLYALAARDIFRQLEVSQPRRHLFVWISFYEIYCGQLYDLLNRRKRLFAREDSKHVVQIVGLRELQVDSVELLLEVILKGSKERSTRATGVNADSSRSHAIIQIQIKDSAKRTFGRISFIDLAGSERAADARDSDRQTKMEGAEINQSLLALKECIRALDQEHTHTPFRQSKLTQVLKDSFIGNAKTCMIANISPSHVATEHTLNTLRYADRVKELKKGIKCCTPANSRNRTSGNSSNASPKRIQSSPVALPGDKYSPKKVKLGLQQPLTVPSGSMRGKAHPLASHPANIPFASVPKVPGREGGSQGSPPREWVIQTSSSKGTMLSGHVAIKRAEESAALCSEKNPIGNKTPLGWGSRAPGPGGDLVRGKPPSRCKRVQTVQPVQKQLVSRGELSFGSAQRLVEYGQGSKVGALSWPASEAWTNNIPVQQEAREEHLRFYHQQFQQPPLLQQKLQYQPLERFLCRSRPPEGQLQSDILPPFHPHRAESQDGAQVPQAEDPDDSDFSEDSFSHASCQRTTKQGKSPENSEGSFFLHQREQGPEEQVAERQQSLFFSPDGDEEGVTRSWVYSRDPAGHRRIALDHGHSPGQVPLDWSGEEDLDSSGPSPREDLAGKSYCAQVDSVYDRERGGGPAFDLRQEAFRSEVPGQAEGSLPSLEDDGFTCSLFHIAVPGSPDQRDTVSTPLREVSEDSPILETRTMKNSNPFQGDDSKGELGTCSEYASGLMAPLTMSLLESLDDGGAPSWEQPAQAGTAHGLVAVDTEGPAMGHTVSSGDPEAVLPTSSATEHLWLSSSPPDDKPGGSLPALSPSPIRQRPPDELPSGEADPGEACQSRGTTLFSRGHRDANAETELDGSQGFLGKPFLTLHPGGPHAGPTLTPRAGNSDVADQPRAQERKQPTGPSWPELGFSTDPITLSCYKEDIAWLKHRPIPRSLARPGSPLAASCSPETAGTLRQPALGHAQ", "length": 1327, "header": "tr|A0AAA9S0T6-1|E1BPB1_BOVIN Computationally mapped isoform of Kinesin-like protein KIF24 OS=Bos taurus OX=9913 GN=KIF24 PE=3 SV=1 CANONICAL=E1BPB1-1" }, "locus": { "chromosome": "8", "start_pos": 75700606, "end_pos": 75654548, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123557.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123557.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079479.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079479.1" } ] } }, { "isoform_ac": "A0AAA9T652-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T652/entry", "sequence": { "sequence": "MTSWLYECLYEAELAQYYPHFTALGLQKIDELANVTMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSSPDSRLQTSNLCVKPQKSRSGPRRQLHFDSPADNKDRTTSNNQFELCDLSDFSASEQKSNYIKVLEHMLPDDSQYHTQTGILNAAAAHSNIQKAAKISPFSSNHFSPVQGDCDSSVIQRVSHVSGYNYGIPHSYIRSQSFRTLRNSLTNLKLPVSESSLSEEHSLWIPQIRQNTSEKENPWTEMEKIRVCVRKRPLGMREVRRGEINIITVKDKETLLVHEKKEAVDLTQYILQHVFYFDEIFDEACTNQDIYMKTTHPLIQHIFNGGNATCFSYGQTGAGKTYTMIGTHQNPGLYALAARDIFRQLEVSQPRRHLFVWISFYEIYCGQLYDLLNRRKRLFAREDSKHVVQIVGLRELQVDSVELLLEVILKGSKERSTRATGVNADSSRSHAIIQIQIKDSAKRTFGRISFIDLAGSERAADARDSDRQTKMEGAEINQSLLAVLKDSFIGNAKTCMIANISPSHVATEHTLNTLRYADRVKELKKGIKCCTPANSRNRTSGNSSNASPKRIQSSPVALPGDKYSPKKVKLGLQQPLTVPSGSMRGKAHPLASHPANIPFASVPKVPGREGGSQGSPPREWVIQTSSSKGTMLSGHVAIKRAEESAALCSEKNPIGNKTPLGWGSRAPGPGGDLVRGKPPSRCKRVQTVQPVQKQLVSRGELSFGSAQRLVEYGQGSKVGALSWPASEAWTNNIPVQQEAREEHLRFYHQQFQQPPLLQQKLQYQPLERFLCRSRPPEGQLQSDILPPFHPHRAESQDGAQVPQAEDPDDSDFSEDSFSHASCQRTTKQGKSPENSEGSFFLHQREQGPEEQVAERQQSLFFSPDGDEEGVTRSWVYSRDPAGHRRIALDHGHSPGQVPLDWSGEEDLDSSGPSPREDLAGKSYCAQVDSVYDRERGGGPAFDLRQEAFRSEVPGQAEGSLPSLEDDGFTCSLFHIAVPGSPDQRDTVSTPLREVSEDSPILETRTMKNSNPFQGDDSKGELGTCSEYASGLMAPLTMSLLESLDDGGAPSWEQPAQAGTAHGLVAVDTEGPAMGHTVSSGDPEAVLPTSSATEHLWLSSSPPDDKPGGSLPALSPSPIRQRPPDELPSGEADPGEACQSRGTTLFSRGHRDANAETELDGSQGFLGKPFLTLHPGGPHAGPTLTPRAGNSDVADQPRAQERKQPTGPSWPELGFSTDPITLSCYKEDIAWLKHRPIPRSLARPGSPLAASCSPETAGTLRQPALGHAQQVVIQAHQEQLDEMAELGFKEETLMSQLAPTDFEGFVIQLDEIMVLKSKCIQSLRSQLQLYLACHKPAAGPKRTAVS", "length": 1379, "header": "tr|A0AAA9T652-1|E1BPB1_BOVIN Computationally mapped isoform of Kinesin-like protein KIF24 OS=Bos taurus OX=9913 GN=KIF24 PE=3 SV=1 CANONICAL=E1BPB1-1" }, "locus": { "chromosome": "8", "start_pos": 75700606, "end_pos": 75652385, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112841.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112841.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091254.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091254.1" } ] } }, { "isoform_ac": "A0AAA9TFH7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFH7/entry", "sequence": { "sequence": "MTSWLYECLYEAELAQYYPHFTALGLQKIDELANVTMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSSPDSRLQTSNLCVKPQKSRSGPRRQLHFDSPADNKDRTTSNNQFELCDLSDFSASEQKSNYIKVLEHMLPDDSQYHTQTGILNAAAAHSNIQKAAKISPFSSNHFSPVQGDCDSSVIQRVSHVSGYNYGIPHSYIRQNTSEKENPWTEMEKIRVCVRKRPLGMREVRRGEINIITVKDKETLLVHEKKEAVDLTQYILQVILKGSKERSTRATGVNADSSRSHAIIQIQIKDSAKRTFGRISFIDLAGSERAADARDSDRQTKMEGAEINQSLLALKECIRALDQEHTHTPFRQSKLTQVLKDSFIGNAKTCMIANISPSHVATEHTLNTLRYADRVKELKKGIKCCTPANSRNRTSGNSSNASPKRIQSSPVALPGDKYSPKKVKLGLQQPLTVPSGSMRGKAHPLASHPANIPFASVPKVPGREGGSQGSPPREWVIQTSSSKGTMLSGHVAIKRAEESAALCSEKNPIGNKTPLGWGSRAPGPGGDLVRGKPPSRCKRVQTVQPVQKQLVSRGELSFGSAQRLVEYGQGSKVGALSWPASEAWTNNIPVQQEAREEHLRFYHQQFQQPPLLQQKLQYQPLERFLCRSRPPEGQLQSDILPPFHPHRAESQDGAQVPQAEDPDDSDFSEDSFSHASCQRTTKQGKSPENSEGSFFLHQREQGPEEQVAERQQSLFFSPDGDEEGVTRSWVYSRDPAGHRRIALDHGHSPGQVPLDWSGEEDLDSSGPSPREDLAGKSYCAQVDSVYDRERGGGPAFDLRQEAFRSEVPGQAEGSLPSLEDDGFTCSLFHIAVPGSPDQRDTVSTPLREVSEDSPILETRTMKNSNPFQGDDSKGELGTCSEYASGLMAPLTMSLLESLDDGGAPSWEQPAQAGTAHGLVAVDTEGPAMGHTVSSGDPEAVLPTSSATEHLWLSSSPPDDKPGGSLPALSPSPIRQRPPDELPSGEADPGEACQSRGTTLFSRGHRDANAETELDGSQGFLGKPFLTLHPGGPHAGPTLTPRAGNSDVADQPRAQERKQPTGPSWPELGFSTDPITLSCYKEDIAWLKHRPIPRSLARPGSPLAASCSPETAGTLRQPALGHAQQVVIQAHQEQLDEMAELGFKEETLMSQLAPTDFEGFVIQLDEIMVLKSKCIQSLRSQLQLYLACHKPAAGPKRTAVS", "length": 1234, "header": "tr|A0AAA9TFH7-1|E1BPB1_BOVIN Computationally mapped isoform of Kinesin-like protein KIF24 OS=Bos taurus OX=9913 GN=KIF24 PE=3 SV=1 CANONICAL=E1BPB1-1" }, "locus": { "chromosome": "8", "start_pos": 75700606, "end_pos": 75652385, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117759.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117759.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095756.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095756.1" } ] } }, { "isoform_ac": "A0AAA9TYZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYZ9/entry", "sequence": { "sequence": "MTSWLYECLYEAELAQYYPHFTALGLQKIDELANVTMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSSPDSRLQTSNLCVKPQKSRSGPRRQLHFDSPADNKDRTTSNNQFELCDLSDFSASEQKSNYIKVLEHMLPDDSQYHTQTGILNAAAAHSNIQKAAKISPFSSNHFSPVQGDCDSSVIQRVSHVSGYNYGIPHSYIRSQSFRTLRNSLTNLKLPVSESSLSEEHSLWIPQIRQNTSEKENPWTEMEKIRVCVRKRPLGMREVRRGEINIITVKDKETLLVHEKKEAVDLTQYILQHVFYFDEIFDEACTNQDIYMKTTHPLIQHIFNGLFAREDSKHVVQIVGLRELQVDSVELLLEVILKGSKERSTRATGVNADSSRSHAIIQIQIKDSAKRTFGRISFIDLAGSERAADARDSDRQTKMEGAEINQSLLALKECIRALDQEHTHTPFRQSKLTQVLKDSFIGNAKTCMIANISPSHVATEHTLNTLRYADRVKELKKGIKCCTPANSRNRTSGNSSNASPKRIQSSPVALPGDKYSPKKVKLGLQQPLTVPSGSMRGKAHPLASHPANIPFASVPKVPGREGGSQGSPPREWVIQTSSSKGTMLSGHVAIKRAEESAALCSEKNPIGNKTPLGWGSRAPGPGGDLVRGKPPSRCKRVQTVQPVQKQLVSRGELSFGSAQRLVEYGQGSKVGALSWPASEAWTNNIPVQQEAREEHLRFYHQQFQQPPLLQQKLQYQPLERFLCRSRPPEGQLQSDILPPFHPHRAESQDGAQVPQAEDPDDSDFSEDSFSHASCQRTTKQGKSPENSEGSFFLHQREQGPEEQVAERQQSLFFSPDGDEEGVTRSWVYSRDPAGHRRIALDHGHSPGQVPLDWSGEEDLDSSGPSPREDLAGKSYCAQVDSVYDRERGGGPAFDLRQEAFRSEVPGQAEGSLPSLEDDGFTCSLFHIAVPGSPDQRDTVSTPLREVSEDSPILETRTMKNSNPFQGDDSKGELGTCSEYASGLMAPLTMSLLESLDDGGAPSWEQPAQAGTAHGLVAVDTEGPAMGHTVSSGDPEAVLPTSSATEHLWLSSSPPDDKPGGSLPALSPSPIRQRPPDELPSGEADPGEACQSRGTTLFSRGHRDANAETELDGSQGFLGKPFLTLHPGGPHAGPTLTPRAGNSDVADQPRAQERKQPTGPSWPELGFSTDPITLSCYKEDIAWLKHRPIPRSLARPGSPLAASCSPETAGTLRQPALGHAQQVVIQAHQEQLDEMAELGFKEETLMSQLAPTDFEGFVIQLDEIMVLKSKCIQSLRSQLQLYLACHKPAAGPKRTAVS", "length": 1331, "header": "tr|A0AAA9TYZ9-1|E1BPB1_BOVIN Computationally mapped isoform of Kinesin-like protein KIF24 OS=Bos taurus OX=9913 GN=KIF24 PE=3 SV=1 CANONICAL=E1BPB1-1" }, "locus": { "chromosome": "8", "start_pos": 75700606, "end_pos": 75652385, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131619.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131619.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103558.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103558.1" } ] } }, { "isoform_ac": "A0ABI0NS12-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS12/entry", "sequence": { "sequence": "MTSWLYECLYEAELAQYYPHFTALGLQKIDELANVTMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSSPDSRLQTSNLCVKPQKSRSGPRRQLHFDSPADNKDRTTSNNQFELCDLSDFSASEQKSNYIKVLEHMLPDDSQYHTQTGILNAAAAHSNIQKAAKISPFSSNHFSPVQGDCDSSVIQRVSHVSGYNYGIPHSYIRSQSFRTLRNSLTNLKLPVSESSLSEEHSLWIPQIRQNTSEKENPWTEMEKIRVCVRKRPLGMREVRRGEINIITVKDKETLLVHEKKEAVDLTQYILQHVFYFDEIFDEACTNQDIYMKTTHPLIQHIFNGGNATCFSYGQTGAGKTYTMIGTHQNPGLYALAARDIFRQLEVSQPRRHLFVWISFYEIYCGQLYDLLNRRKRLFAREDSKHVVQIVGLRELQVDSVELLLEVLKDSFIGNAKTCMIANISPSHVATEHTLNTLRYADRVKELKKGIKCCTPANSRNRTSGNSSNASPKRIQSSPVALPGDKYSPKKVKLGLQQPLTVPSGSMRGKAHPLASHPANIPFASVPKVPGREGGSQGSPPREWVIQTSSSKGTMLSGHVAIKRAEESAALCSEKNPIGNKTPLGWGSRAPGPGGDLVRGKPPSRCKRVQTVQPVQKQLVSRGELSFGSAQRLVEYGQGSKVGALSWPASEAWTNNIPVQQEAREEHLRFYHQQFQQPPLLQQKLQYQPLERFLCRSRPPEGQLQSDILPPFHPHRAESQDGAQVPQAEDPDDSDFSEDSFSHASCQRTTKQGKSPENSEGSFFLHQREQGPEEQVAERQQSLFFSPDGDEEGVTRSWVYSRDPAGHRRIALDHGHSPGQVPLDWSGEEDLDSSGPSPREDLAGKSYCAQVDSVYDRERGGGPAFDLRQEAFRSEVPGQAEGSLPSLEDDGFTCSLFHIAVPGSPDQRDTVSTPLREVSEDSPILETRTMKNSNPFQGDDSKGELGTCSEYASGLMAPLTMSLLESLDDGGAPSWEQPAQAGTAHGLVAVDTEGPAMGHTVSSGDPEAVLPTSSATEHLWLSSSPPDDKPGGSLPALSPSPIRQRPPDELPSGEADPGEACQSRGTTLFSRGHRDANAETELDGSQGFLGKPFLTLHPGGPHAGPTLTPRAGNSDVADQPRAQERKQPTGPSWPELGFSTDPITLSCYKEDIAWLKHRPIPRSLARPGSPLAASCSPETAGTLRQPALGHAQQVVIQAHQEQLDEMAELGFKEETLMSQLAPTDFEGFVIQLDEIMVLKSKCIQSLRSQLQLYLACHKPAAGPKRTAVS", "length": 1303, "header": "tr|A0ABI0NS12-1|A0ABI0NS12_BOVIN Computationally mapped isoform of Kinesin family member 24 OS=Bos taurus OX=9913 GN=KIF24 PE=3 SV=1 CANONICAL=E1BPB1-1" }, "locus": { "chromosome": "8", "start_pos": 75700606, "end_pos": 75652385, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154638.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154638.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106608.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106608.1" } ] } }, { "isoform_ac": "E1BPB1-1", "url": "https://www.uniprot.org/uniprotkb/E1BPB1/entry", "sequence": { "sequence": "MTSWLYECLYEAELAQYYPHFTALGLQKIDELANVTMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSSPDSRLQTSNLCVKPQKSRSGPRRQLHFDSPADNKDRTTSNNQFELCDLSDFSASEQKSNYIKVLEHMLPDDSQYHTQTGILNAAAAHSNIQKAAKISPFSSNHFSPVQGDCDSSVIQRVSHVSGYNYGIPHSYIRQNTSEKENPWTEMEKIRVCVRKRPLGMREVRRGEINIITVKDKETLLVHEKKEAVDLTQYILQHVFYFDEIFDEACTNQDIYMKTTHPLIQHIFNGGNATCFSYGQTGAGKTYTMIGTHQNPGLYALAARDIFRQLEVSQPRRHLFVWISFYEIYCGQLYDLLNRRKRLFAREDSKHVVQIVGLRELQVDSVELLLEVILKGSKERSTRATGVNADSSRSHAIIQIQIKDSAKRTFGRISFIDLAGSERAADARDSDRQTKMEGAEINQSLLALKECIRALDQEHTHTPFRQSKLTQVLKDSFIGNAKTCMIANISPSHVATEHTLNTLRYADRVKELKKGIKCCTPANSRNRTSGNSSNASPKRIQSSPVALPGDKYSPKKVKLGLQQPLTVPSGSMRGKAHPLASHPANIPFASVPKVPGREGGSQGSPPREWVIQTSSSKGTMLSGHVAIKRAEESAALCSEKNPIGNKTPLGWGSRAPGPGGDLVRGKPPSRCKRVQTVQPVQKQLVSRGELSFGSAQRLVEYGQGSKVGALSWPASEAWTNNIPVQQEAREEHLRFYHQQFQQPPLLQQKLQYQPLERFLCRSRPPEGQLQSDILPPFHPHRAESQDGAQVPQAEDPDDSDFSEDSFSHASCQRTTKQGKSPENSEGSFFLHQREQGPEEQVAERQQSLFFSPDGDEEGVTRSWVYSRDPAGHRRIALDHGHSPGQVPLDWSGEEDLDSSGPSPREDLAGKSYCAQVDSVYDRERGGGPAFDLRQEAFRSEVPGQAEGSLPSLEDDGFTCSLFHIAVPGSPDQRDTVSTPLREVSEDSPILETRTMKNSNPFQGDDSKGELGTCSEYASGLMAPLTMSLLESLDDGGAPSWEQPAQAGTAHGLVAVDTEGPAMGHTVSSGDPEAVLPTSSATEHLWLSSSPPDDKPGGSLPALSPSPIRQRPPDELPSGEADPGEACQSRGTTLFSRGHRDANAETELDGSQGFLGKPFLTLHPGGPHAGPTLTPRAGNSDVADQPRAQERKQPTGPSWPELGFSTDPITLSCYKEDIAWLKHRPIPRSLARPGSPLAASCSPETAGTLRQPALGHAQQVVIQAHQEQLDEMAELGFKEETLMSQLAPTDFEGFVIQLDEIMVLKSKCIQSLRSQLQLYLACHKPAAGPKRTAVS", 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"NP_001178106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178106", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWH1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWH1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWZ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N6T2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6T2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N6T2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6T2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPH4", "url": "https://www.uniprot.org/uniprotkb/E1BPH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPH4-1", "url": "https://www.uniprot.org/uniprotkb/E1BPH4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVQLYNLHPFGSQQVVPCKLEPERFCGGGRDTLFVAAGCKVEAFTVVGQELCQPRCVFSTLGRVLRLAYSEAGDYLVAIEEKNKATFLRAYVNWRSKRTENSRVCIRMVGHDVEAPFSETFRDQMSIVEMPLSEAPLCISCCPVKGDLLVGCTNNLVLFSLKYQIINEEFSILDFERSLVIHIDNITPAEISFCVGYVAVMSELEVLIVKLESDPKNRESVNYRPHKTTNPTKQAEGISNETSQLESDDFVICQKPMELLGEKSKQSGISVTLESTGLADEKIKYFHVRHLLYRRFAPDISSCLLSDDVRLHSLQLLPIYQTGSLTSDRKNSSQEKVLLSLFCFFSLPHVGYLYMIVKSVELLSVYQYPEKSQQAVLTPQFLHVITSNNLQCYTVRCSAAAAREEDPYVDTTLKACPPISMAVCALRIQLFIGLKAICHFKNHVVLLTKADPETVPERRESPKRFLSRKGTSVNPKTPPVAEAGWNLYIVNTISPVQLYKEMVDYSNAYKTAKTQSCVHLLSEAHLLVRAALMDASQLEPGEKAELLEAFKESCGHLGDCYSRLETQHSHLALPYYKMSGLSMAEVLNRVDWAVEDGSQKYERGLIFYINHSLYENLDEELSEELSAKVVQMFYAAEPKQLPHILCSPSMKNIDPLTAIKYLRKLDTSGFSSVLVTLAKAAMALKMGDLDMHRNEMKSHSEMKLVCGFILEPRLLIQQRKGQIVPTEFAVHLKETQPGLLVASVLALQKNNKIGIEEADSFFKVLCGKDGDTIPQLLVDFWEAQLVACLPDVVLQELFFKLTSQYIWRLSKRQPPDTTPLRTSEDLINTCSHYGLINPWVNVLISSESLVDKNYMEDLSKLQSLICGPSFDIASIVPFLEPLSEDTVAGLSVHVLCHTRLKEYDQCIDRLLERCPEAVIPYANHELKEENRTLWWKKLLPELCQRIKCGGEKYQLYLSSLKETLSVVAVELELRDFLNVLPEDGTAAFFLPYLLYCSRKKSLT", "length": 1003, "header": "tr|E1BPH4-1|E1BPH4_BOVIN Isoform 1 of Hermansky-Pudlak syndrome 3 protein homolog OS=Bos taurus OX=9913 GN=HPS3 PE=4 SV=2 CANONICAL=E1BPH4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWH1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWH1/entry", "sequence": { "sequence": "MVQLYNLHPFGSQQVVPCKLEPERFCGGGRDTLFVAAGCKVEAFTVVGQELCQPRCVFSTLGRVLRLAYSEAGDYLVAIEEKNKATFLRAYVNWRSKRTENSRVCIRMVGHDVEAPFSETFRDQMSIVEMPLSEAPLCISCCPVKGDLLVGCTNNLVLFSLKYQIINEEFSILDFERSLVIHIDNITPAEISFCVGYVAVMSELEVLIVKLESDPKNRESVNYRPHKTTNPTKQAEGISNETSQLESDDFVICQKPMELLGEKSKQSGISVTLESTGLADEKIKYFHVRHLLYRRFAPDISSCLLSDDVRLHSLQLLPIYQTGSLTSDRKNSSQEKVLLSLFCFFSLPHVGYLYMIVKSVELLSVYQYPEKSQQAVLTPQFLHVITSNNLQCYTVRCSAAAAREEDPYVDTTLKACPPISMAVCALRIQLFIGLKAICHFKNHVVLLTKADPETVPERRESPKRFLSRKGTSVNPKTPPVAEAGWNLYIVNTISPVQLYKEMVDYSNAYKTAKTQSCVHLLSEAHLLVRAALMDASQLEPGEKAELLEAFKESCGHLGDCYSRLETQHSHLALPYYKMSGLSMAEVLNRVDWAVEDGSQKYERGLIFYINHSLYENLDEELSEELSAKVVQMFYAAEPKQLPHILCSPSMKNIDPLTAIKYLRKLDTSGFSSVLVTLAKAAMALKMGDLDMHRNEMKSHSEMKLVCGFILEPRLLIQQRKGQIVPTEFAVHLKETQPGLLVASVLALQKNNKIGIEEADSFFKVLCGKDGDTIPQLLVDFWEAQLVACLPDVVLQELFFKLTSQYIWRLSKRQPPDTTPLRTSEDLINTCSHYGLINPWVNVLISSESLVDKNYMEDLSKLQSLICGPSFDIASIVPFLEPLSEDTVAGLSVHVLCHTRLKEYDQCIDRLLERCPEAVIPYANHELKEENRTLWWKKLLPELCQRIKCGGEKYQLYLSSLKGVLFTTEPRGKSKKT", "length": 976, "header": "tr|A0A3Q1LWH1-1|E1BPH4_BOVIN Computationally mapped isoform of Hermansky-Pudlak syndrome 3 protein homolog OS=Bos taurus OX=9913 GN=HPS3 PE=4 SV=2 CANONICAL=E1BPH4-1" }, "locus": { "chromosome": "1", "start_pos": 119045977, "end_pos": 119002600, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075485.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075485.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061581.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061581.2" } ] } }, { "isoform_ac": "A0A3Q1MWZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWZ7/entry", "sequence": { "sequence": "MVQLYNLHPFGSQQVVPCKLEPERFCGGGRDTLFVAAGCKVEAFTVVGQELCQPRCVFSTLGRVLRLAYSEAGDYLVAIEEKNKATFLRAYVNWRSKRTENSRVCIRMVGHDVEAPFSETFRDQMSIVEMPLSEAPLCISCCPVKGDLLVGCTNNLVLFSLKYQIINEEFSILDFERSLVIHIDNITPAEISFCVGYVAVMSELEVLIVKLESDPKNRESVNYRPHKTTNPTKQAEGISNETSQLESDDFVICQKPMELLGEKSKQSGISVTLESTGLADEKIKYFHVRHLLYRRFAPDISSCLLSDDVRLHSLQLLPIYQTGSLTSDRKNSSQEKVLLSLFCFFSLPHVGYLYMIVKSVELLSVYQYPEKSQQAVLTPQFLHVITSNNLQCYTVRCSAAAAREEDPYVDTTLKACPPISMAVCALRIQLFIGLKAICHFKNHVVLLTKADPETVPERRESPKRFLSRKGTSVNPKTPPVAEAGWNLYIVNTISPVQLYKEMVDYSNAYKTAKTQSCVHLLSEAHLLVRAALMDASQLEPGEKAELLEAFKESCGHLGDCYSRLETQHSHLALPYYKMSGLSMAEVLNRVDWAVEDGSQKYERGLIFYINHSLYENLDEELSEELSAKVVQMFYAAEPKQLPHILCSPSMKNIDPLTAIKYLRKLDTSGFSSVLVTLAKAAMALKMGDLDMHRNEMKSHSEMKLVCGFILEPRLLIQQRKGQIVPTEFAVHLKETQPGLLVASVLALQKNNKIGIEEADSFFKVLCGKDGDTIPQLLVDFWEAQLVACLPDVVLQELFFKLTSQYIWRLSKRQPPDTTPLRTSEDLINTCSHYGLINPWVNVLISSESLVDKNYMEDLSKLQSLICGPSFDIASIVPFLEPLSEDTVAGLSVHVLCHTRLKEYDQCIDRLLERCPEAVIPYANHELKEENRVCFSDYVF", "length": 939, "header": "tr|A0A3Q1MWZ7-1|E1BPH4_BOVIN Computationally mapped isoform of Hermansky-Pudlak syndrome 3 protein homolog OS=Bos taurus OX=9913 GN=HPS3 PE=4 SV=2 CANONICAL=E1BPH4-1" }, "locus": { "chromosome": "1", "start_pos": 119045977, "end_pos": 119010839, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073655.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073655.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060157.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060157.2" } ] } }, { "isoform_ac": "A0A3Q1N6T2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6T2/entry", "sequence": { "sequence": "MVQLYNLHPFGSQQVVPCKLEPERFCGGGRDTLFVAAGCKVEAFTVVGQELCQPRCVFSTLGRVLRLAYSEAGISNETSQLESDDFVICQKPMELLGEKSKQSGISVTLESTGLADEKIKYFHVRHLLYRRFAPDISSCLLSDDVRLHSLQLLPIYQTGSLTSDRKNSSQEKVLLSLFCFFSLPHVGYLYMIVKSVELLSVYQYPEKSQQAVLTPQFLHVITSNNLQCYTVRCSAAAAREEDPYVDTTLKACPPISMAVCALRIQLFIGLKAICHFKNHVVLLTKADPETVPERRESPKRFLSRKGTSVNPKTPPVAEAGWNLYIVNTISPVQLYKEMVDYSNAYKTAKTQSCVHLLSEAHLLVRAALMDASQLEPGEKAELLEAFKESCGHLGDCYSRLETQHSHLALPYYKMSGLSMAEVLNRVDWAVEDGSQKYERGLIFYINHSLYENLDEELSEELSAKVVQMFYAAEPKQLPHILCSPSMKNIDPLTAIKYLRKLDTSGFSSVLVTLAKAAMALKMGDLDMHRNEMKSHSEMKLVCGFILEPRLLIQQRKGQIVPTEFAVHLKETQPGLLVASVLALQKNNKIGIEEADSFFKVLCGKDGDTIPQLLVDFWEAQLVACLPDVVLQELFFKLTSQYIWRLSKRQPPDTTPLRTSEDLINTCSHYGLINPWVNVLISSESLVDKNYMEDLSKLQSLICGPSFDIASIVPFLEPLSEDTVAGLSVHVLCHTRLKEYDQCIDRLLERCPEAVIPYANHELKEENRTLWWKKLLPELCQRIKCGGEKYQLYLSSLKETLSVVAVELELRDFLNVLPEDGTAAFFLPYLLYCSRKKSLT", "length": 839, "header": "tr|A0A3Q1N6T2-1|E1BPH4_BOVIN Computationally mapped isoform of Hermansky-Pudlak syndrome 3 protein homolog OS=Bos taurus OX=9913 GN=HPS3 PE=4 SV=2 CANONICAL=E1BPH4-1" }, "locus": { "chromosome": "1", "start_pos": 119045977, "end_pos": 119005744, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082730.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082730.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066264.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066264.2" } ] } }, { "isoform_ac": "E1BPH4-1", "url": "https://www.uniprot.org/uniprotkb/E1BPH4/entry", "sequence": { "sequence": "MVQLYNLHPFGSQQVVPCKLEPERFCGGGRDTLFVAAGCKVEAFTVVGQELCQPRCVFSTLGRVLRLAYSEAGDYLVAIEEKNKATFLRAYVNWRSKRTENSRVCIRMVGHDVEAPFSETFRDQMSIVEMPLSEAPLCISCCPVKGDLLVGCTNNLVLFSLKYQIINEEFSILDFERSLVIHIDNITPAEISFCVGYVAVMSELEVLIVKLESDPKNRESVNYRPHKTTNPTKQAEGISNETSQLESDDFVICQKPMELLGEKSKQSGISVTLESTGLADEKIKYFHVRHLLYRRFAPDISSCLLSDDVRLHSLQLLPIYQTGSLTSDRKNSSQEKVLLSLFCFFSLPHVGYLYMIVKSVELLSVYQYPEKSQQAVLTPQFLHVITSNNLQCYTVRCSAAAAREEDPYVDTTLKACPPISMAVCALRIQLFIGLKAICHFKNHVVLLTKADPETVPERRESPKRFLSRKGTSVNPKTPPVAEAGWNLYIVNTISPVQLYKEMVDYSNAYKTAKTQSCVHLLSEAHLLVRAALMDASQLEPGEKAELLEAFKESCGHLGDCYSRLETQHSHLALPYYKMSGLSMAEVLNRVDWAVEDGSQKYERGLIFYINHSLYENLDEELSEELSAKVVQMFYAAEPKQLPHILCSPSMKNIDPLTAIKYLRKLDTSGFSSVLVTLAKAAMALKMGDLDMHRNEMKSHSEMKLVCGFILEPRLLIQQRKGQIVPTEFAVHLKETQPGLLVASVLALQKNNKIGIEEADSFFKVLCGKDGDTIPQLLVDFWEAQLVACLPDVVLQELFFKLTSQYIWRLSKRQPPDTTPLRTSEDLINTCSHYGLINPWVNVLISSESLVDKNYMEDLSKLQSLICGPSFDIASIVPFLEPLSEDTVAGLSVHVLCHTRLKEYDQCIDRLLERCPEAVIPYANHELKEENRTLWWKKLLPELCQRIKCGGEKYQLYLSSLKETLSVVAVELELRDFLNVLPEDGTAAFFLPYLLYCSRKKSLT", "length": 1003, "header": "tr|E1BPH4-1|E1BPH4_BOVIN Isoform 1 of Hermansky-Pudlak syndrome 3 protein homolog OS=Bos taurus OX=9913 GN=HPS3 PE=4 SV=2 CANONICAL=E1BPH4-1" }, "locus": { "chromosome": "1", "start_pos": 119045977, "end_pos": 119005744, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003112.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003112.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003112.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003112.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783104", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783104", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0X460-1", "protein_name": "HPS3 biosis of lysosomal organelles complex 2 subunit 1", "gene_name": "HPS3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVQLYNLHPFGSQRVVPCKQEPAQFCCGHDVLFVASAAASCGVEVFAVRREGRCEPLGSFATLGPVLRMAHSRAGDYLVTIEEKSKATFLRAYVNWRFMSAGSSRVCVRMVGHKMEESYTETLKDQMSIVEMALSDPPLCISCCPVNGDLLVGCKNKLVMFRLKYLVISQNLRVLDFERSLILHIDNFIPAEVAFCARHIAITTELDVLILKLVQQNADRGEQCTYQVSTIEKPVDGGIKDEDLAAHSLQLELDEFVICQKPVELLGEESKLCKIPVTLESTELSTEDKKHFEVQYLLFRRFTPDQSPFGFCEETKLHSVQFLPVYQTGSSVTANEETENKRELLSLFCFFSLPHVGYLYSVGKLVELISTYQYSEKSEQAVLTPQFLHVITSESLQCFTVRCSAAAARDEDPYIDTTVKACPPVTLDVCTLRMQLFIGPRAICHYKNHIILLTKADTEDITERRKPSRRMLSRKADSNKSRTNSESEPGWNLYIINTVSTIQLYREMVDYSRTYENVRTESCIHLLSEAHLLVRAAIMDPSFFKSDEKEELLRAFRESCALLGDCYSRFDTKDYHLALPYYRMSGLSVTEVLERRASESDEIQTYERGFIFYLTHSLNEELNEELSKELADKVLQIFYLADPVQLPHIICSPCMKNVCPLTAVKYLRKVEDIMPSVVLTLTKAFMALKMGDLMMYECEMNSHKETMLACGFVGQPKLLRECKEGIVIPTEFAVHLKAMQPGLLVAATVALHENSKIELEEADMFFKMLCNNGEDTVPQLLVDFWEALLVACSQEEVLPELLLRVTHQYVWRISKKQLPETKPLKTTEDLINSCDHFGFIFPWVTFIMSMESPLGKDCPEDISKLQSVLCGQSIDITAALPILEPLADAGNVGLTIRVLCSTRLGKYEESIDQLLRQYPAAAVLYAQHELKGDSQAVWWNKLLPELCERARLTRSDCPVLISSLKETLSVVATELELRDFLSLLPEDGTAAFFLPHLLHCSQRKLLR", "length": 1007 }, "evidence": [ { "id": "E1BPH4", "url": "https://omabrowser.org/oma/group/E1BPH4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZGG8-1", "protein_name": "Hermansky-Pudlak syndrome 3 protein homolog", "gene_name": "Hps3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVRLYNLHPFGSQQVVPCQREPEQFCCGGSDALFVASGCKVEAFAVQGAELSRQRCTFSTLGRVLRMAYSEAGDYLVAIEEKNKTVFLRAYVNWRSKRNDNSRVCIRMVGHKMEASFCESFRDQMSIIEMPMSEAPLCISCCPVKGDLLVGCTKKLVLFTLKYDVVNEEFSMLNFERSLIIHINNITPVEISFCVGYVAVMADLEVLLLKLESDPIHGEGVNHHPQESINPLEQTEDVSNETSQLESEDFVICLKPLELFGEKCKQSGISVKLESTGLEDEKVKYLHVQHLLYRRFAPDISFYGLSDNIKLHSLQLLPIHQTGFHPDEKDLSQKKEVPSLFCFFSLPHAGYLYMVVKSVTLLSVYWYPEKSQQAVLTPQFLHVITSQSLQCFTVRCSAAVAHEEDLYMDTTLKACPPVSMDVCALRIQLFIGLKAICHFKNHIILLTKAEPEDIPERRESPKRLLSRKDASVKSRIPHVAEAGWNLYIVNTTAPVQLYKEMVDYSNSYKTVKTESCLHLLSEAHLLVRAALMDVSQLEPAEKAELLEAFKESCGHLGDCYSRLNTEQAHLALPYYKMSGLSLAEVLARVEWTEGNESQKYERGLIFYINHSLYENLDEELSEELAGKVAQIFHVAEPKQLPHVLSSPSMKNIDPLIALHYLRKLDTCGASPVLVTLTKAAVALKMGNLDMYRNEMKSHSEMQLVYGFILEPRLLIQQWKGQIVPTELAIDLKETQPGLLVASVLGLQKNGKIGIEEADSFFKVLCGKDEDMVPQLLVDFWEAQLVACLPDVVLEELFFKLISQYVWRLSKRHCPDTLPLRTAEDLINACSHYGLVYPWVHVLMTSDSLADKNYTEDLLKLQSLICSPSLDIVSVIPYLEPLSEDTVAGLSAQVLCHTRLQEYEKCIDTLLERCPEAVIAYANRELKEEHWILWWKKLLPELCHRVKCGGDRYHLHLSLLKETLSVVAVGLDLRDFLNVLPEDGVAAFFLPYLLFCSRKKSLT", "length": 1002 }, "evidence": [ { "id": "E1BPH4", "url": "https://omabrowser.org/oma/group/E1BPH4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91VB4-1", "protein_name": "BLOC-2 complex member HPS3", "gene_name": "Hps3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVRLYNLHPFGSQQVVPCQWEPEQVCCGGSDALFVAAGCKVEAFAVQGEELCRQRCAFSTLGRVLRMAYSEAGDYLVAIEEKNKTIFLRAYVNWRSKRSDNSRVCIRMVGHNVEASFCESFRDQMSIIEMPMSEAPLCFSCCPVKGDLLVGCTNKLVLFTLKYDIINEEFSILNFERSLIIHIDNITPVEISFCVGYVAVMSDLEVLLLKLESDPIHGESVDHHPQETSNPLKEAEGVSNETSQLESEDFVICLKPMELIGEKCEQSGISVKLESTGLEDEKVKYLRVRHLLYRRFAPDISSYVLSDNIKLHSLQLLPIHQSGFHPDENDLSPKKEMPNLFCFFSLPHVGYLYMVVKSVELMSVYWYPEKSQQAVLTPQFLHVITSQSLQCFTVRCSAAVAHEEDLYMDTTLKACPPVSMDVCALRIQLFIGLKAICHFKNHIILLTKAEPEAIPERRESPKKLISRKDASVRSGTPHVAEAAWNLYLVNTTAPVQLYKEMVDYSNSYKTVKTESCLHLLSEAHLLVRAALMDGSQLEPAEKAELLEAFKESCGHLGDCYSRLTTEQSHLALPYYKMSGLSLAEVLARVDWTEESESQKYERGLVFYINHSLYENLDEELSKELAAKVAQIFHMAEPKQLPHVLSSPSMKNIDPLTALHYLRKLDSCGVSPVLVTLTKAAVALKMGDLDMYRNEMKSHSEMKLVYGFILEPRLLIQQWKGQIVPTELAIDLKETQPGLLVASVLGLQKNDKIGIVETDSFFKVLCGKDEDAVPQLLIDFWEAQLVACLPNVVLEELFFKLISQYVWRLSERRCPDTVPLRTAEDLINACSHYGLVNPWVHVLTTSDSLADKNYTDDLLKLQSLICSPSLDVASIIPFLEPLSEDTVAGLSTHALCHTRLQEYEQCIDTLLERCPEAVIAYANQELKEDHWILWWKKLLPELCQRVKSGGERSHLHLSLLKETLSVIAVGLDLRDFLNVLPEDGAAAFFLPYLLFCSRKKSLT", "length": 1002 }, "evidence": [ { "id": "E1BPH4", "url": "https://omabrowser.org/oma/group/E1BPH4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q969F9-1", "protein_name": "BLOC-2 complex member HPS3", "gene_name": "HPS3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVQLYNLHPFGSQQVVPCKLEPDRFCGGGRDALFVAAGCKVEAFAVAGQELCQPRCAFSTLGRVLRLAYSEAGDYLVAIEEKNKATFLRAYVNWRNKRTENSRVCIRMIGHNVEGPFSKAFRDQMYIIEMPLSEAPLCISCCPVKGDLLVGCTNKLVLFSLKYQIINEEFSLLDFERSLIIHIDNITPVEVSFCVGYVAVMSDLEVLIVKLESGPKNGERVHHHPHKTNNRIRRTEEGISNEISQLESDDFVICQKPLELLGEKSEQSGLSVTLESTGLADEKRKYSHFQHLLYRRFAPDISSYVLSDDIKLHSLQLLPIYQTGSLTSDGKNLSQEKELLSLFCFFSLPHVGYLYMVVKSVELMSVYQYPEKSQQAVLTPQFLHVITSNNLQCFTVRCSAAAAREEDPYMDTTLKACPPVSMDVCALRIQLFIGLKAICHFKNHIILLTKAEPEAIPERRQSPKRLLSRKDTSVKIKIPPVAEAGWNLYIVNTISPVQLYKEMVDYSNTYKTVKTQSCIHLLSEAHLLVRAALMDASQLEPGEKAELLEAFKESCGHLGDCYSRLDSQHSHLTLPYYKMSGLSMAEVLARTDWTVEDGLQKYERGLIFYINHSLYENLDEELNEELAAKVVQMFYVAEPKQVPHILCSPSMKNINPLTAMSYLRKLDTSGFSSILVTLTKAAVALKMGDLDMHRNEMKSHSEMKLVCGFILEPRLLIQQRKGQIVPTELALHLKETQPGLLVASVLGLQKNNKIGIEEADSFFKVLCAKDEDTIPQLLVDFWEAQLVACLPDVVLQELFFKLTSQYIWRLSKRQPPDTTPLRTSEDLINACSHYGLIYPWVHVVISSDSLADKNYTEDLSKLQSLICGPSFDIASIIPFLEPLSEDTIAGLSVHVLCRTRLKEYEQCIDILLERCPEAVIPYANHELKEENRTLWWKKLLPELCQRIKCGGEKYQLYLSSLKETLSIVAVELELKDFMNVLPEDGTATFFLPYLLYCSRKKPLT", "length": 1004 }, "evidence": [ { "id": "E1BPH4", "url": "https://omabrowser.org/oma/group/E1BPH4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BPH4", "url": "https://www.uniprot.org/uniprotkb/E1BPH4" } ], "pmid": "" }, { "name": "BLOC-2 complex", "id": "GO:0031084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031084", "evidence": [ { "database": "UniProtKB", "id": "E1BPH4", "url": "https://www.uniprot.org/uniprotkb/E1BPH4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "pigmentation", "id": "GO:0043473", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043473", "evidence": [ { "database": "UniProtKB", "id": "E1BPH4", "url": "https://www.uniprot.org/uniprotkb/E1BPH4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 240, "end_pos": 242, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 610, "end_pos": 612, "annotation": "n_glycosylation_sequon" }, { "start_pos": 930, "end_pos": 932, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPH4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1003, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPH4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPH4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPH4", "database": 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}, { "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB08-1", "url": "https://www.uniprot.org/uniprotkb/F1MB08-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSILKVHAREIFDSRGNPTVEVDLFTAKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSRPVKYINEFLAPALCTQKLNVVEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNAEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAENFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKNAIGKAGYSDKVVIGMDVAASEFYRSGKYDLDFKSPDDPSRYITPDELANLYKSFIRDYPVVSIEDPFDQDDWEAWQKFTASAGIQVVGDDLTVTNPKRIAKAVSEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK", "length": 434, "header": "tr|F1MB08-1|F1MB08_BOVIN Isoform 1 of phosphopyruvate hydratase OS=Bos taurus OX=9913 GN=ENO1 PE=3 SV=3 CANONICAL=F1MB08-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LGA6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGA6/entry", "sequence": { 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"https://www.ensembl.org/id/ENSBTAP00000057441.3" } ] } }, { "isoform_ac": "A0A3Q1MIY8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIY8/entry", "sequence": { "sequence": "MSILKVHAREIFDSRGNPTVEVDLFTAKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVVEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNAEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAENFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKNAIGKAGYSDKVVIGMDVAASEFYRSGKYDLDFKSPDDPSRYITPDELANLYKSFIRDYPVVSIEDPFDQDDWEAWQKFTASAGIQVVGDDLTVTNPKRIAKAVSEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK", "length": 434, "header": "tr|A0A3Q1MIY8-1|F1MB08_BOVIN Computationally mapped isoform of phosphopyruvate hydratase OS=Bos taurus OX=9913 GN=ENO1 PE=3 SV=3 CANONICAL=F1MB08-1" }, "locus": { "chromosome": "16", "start_pos": 44566421, "end_pos": 44555441, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075368.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075368.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074298.3", "url": "https://www.ensembl.org/id/ENSBTAP00000074298.3" } ] } }, { "isoform_ac": "A0A3Q1MXQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXQ0/entry", "sequence": { "sequence": "MSILKVHAREIFDSRGNPTVEVDLFTAKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVVEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNAEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAENFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKNAIGKAGYSDKVVIGMDVAASEFYRSGKYDLDFKSPDDPSRYITPDELANLYKSFIRDYPVVSIEDPFDQDDWEAWQKFTASAGIQVVGDDLTVTNPKRIAKAVSEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRYFVISLVYISDKALLLFFNITTLP", "length": 436, "header": "tr|A0A3Q1MXQ0-1|F1MB08_BOVIN Computationally mapped isoform of phosphopyruvate hydratase OS=Bos taurus OX=9913 GN=ENO1 PE=3 SV=3 CANONICAL=F1MB08-1" }, "locus": { "chromosome": "16", "start_pos": 44565864, "end_pos": 44555441, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085415.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085415.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060578.3", "url": "https://www.ensembl.org/id/ENSBTAP00000060578.3" } ] } }, { "isoform_ac": "A0AAA9S2P0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2P0/entry", "sequence": { "sequence": "MSIEKIWAREILDSRGNPTVEVDLHTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGESLCLFWAPCLSGLSVVEQEKLDNLMLDLDGTENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPADPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACRLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL", "length": 427, "header": "tr|A0AAA9S2P0-1|F1MB08_BOVIN Computationally mapped isoform of phosphopyruvate hydratase OS=Bos taurus OX=9913 GN=ENO1 PE=3 SV=1 CANONICAL=F1MB08-1" }, "locus": { "chromosome": "5", "start_pos": 103545275, "end_pos": 103539159, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131263.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131263.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079317.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079317.1" } ] } }, { "isoform_ac": "A0AAA9S6H6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6H6/entry", "sequence": { "sequence": "MARRRGGGRGLGGVPSGLGRKSCPAARRRARGSRSARSLPLIGHPWCPQHSLPLSRAATSGGRKVTMSILKVHAREIFDSRGNPTVEVDLFTAKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVVEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNAEVILPVPAFNVINGGSHAGNKLAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKNAIGKAGYSDKVVIGMDVAASEFYRSGKYDLDFKSPDDPSRYITPDELANLYKSFIRDYPVVSIEDPFDQDDWEAWQKFTASAGIQVVGDDLTVTNPKRIAKAVSEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK", "length": 483, "header": "tr|A0AAA9S6H6-1|F1MB08_BOVIN Computationally mapped isoform of phosphopyruvate hydratase OS=Bos taurus OX=9913 GN=ENO1 PE=3 SV=1 CANONICAL=F1MB08-1" }, "locus": { "chromosome": "16", "start_pos": 44566421, "end_pos": 44553028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110363.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110363.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079499.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079499.1" } ] } }, { "isoform_ac": "A0AAA9S783-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S783/entry", "sequence": { "sequence": "MGGTSAGHWSEGGLGLVHTPPICWGSGDAPARSSPTSLHSLPLSRAATSGGRKVTMSILKVHAREIFDSRGNPTVEVDLFTAKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVVEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNAEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAENFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKNAIGKAGYSDKVVIGMDVAASEFYRSGKYDLDFKSPDDPSRYITPDELANLYKSFIRDYPVVSIEDPFDQDDWEAWQKFTASAGIQVVGDDLTVTNPKRIAKAVSEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK", "length": 489, "header": "tr|A0AAA9S783-1|F1MB08_BOVIN Computationally mapped isoform of phosphopyruvate hydratase OS=Bos taurus OX=9913 GN=ENO1 PE=3 SV=1 CANONICAL=F1MB08-1" }, "locus": { "chromosome": "16", "start_pos": 44566421, "end_pos": 44552829, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094695.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094695.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081071.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081071.1" } ] } }, { "isoform_ac": "A0AAA9T0Q3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0Q3/entry", "sequence": { "sequence": "MSIEKIWAREILDSRGNPTVEVDLHTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKAKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPADPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACRLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL", "length": 391, "header": "tr|A0AAA9T0Q3-1|F1MB08_BOVIN Computationally mapped isoform of phosphopyruvate hydratase OS=Bos taurus OX=9913 GN=ENO1 PE=3 SV=1 CANONICAL=F1MB08-1" }, "locus": { "chromosome": "5", "start_pos": 103545275, "end_pos": 103539159, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098147.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098147.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090118.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090118.1" } ] } }, { "isoform_ac": "A0AAA9TCS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCS0/entry", "sequence": { "sequence": "MARRRGGGRGLGGVPSGLGRKSCPAARRRARGSRSARSLPLIGHPWCPQHSLPLSRAATSGGRKVTMSILKVHAREIFDSRGNPTVEVDLFTAKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVVEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNAEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAENFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKNAIGKAGYSDKVVIGMDVAASEFYRSGKYDLDFKSPDDPSRYITPDELANLYKSFIRDYPVVSIEDPFDQDDWEAWQKFTASAGIQVVGDDLTVTNPKRIAKAVSEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK", "length": 500, "header": "tr|A0AAA9TCS0-1|F1MB08_BOVIN Computationally mapped isoform of phosphopyruvate hydratase OS=Bos taurus OX=9913 GN=ENO1 PE=3 SV=1 CANONICAL=F1MB08-1" }, "locus": { "chromosome": "16", "start_pos": 44566421, "end_pos": 44553028, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126489.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126489.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093929.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093929.1" } ] } }, { "isoform_ac": "A0AAA9TG96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TG96/entry", "sequence": { "sequence": "MSIEKIWAREILDSRGNPTVEVDLHTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKAVDHINTTIAPVLISSGLSVVEQEKLDNLMLDLDGTENKSLELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPADPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACRLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL", "length": 315, "header": "tr|A0AAA9TG96-1|F1MB08_BOVIN Computationally mapped isoform of phosphopyruvate hydratase OS=Bos taurus OX=9913 GN=ENO1 PE=3 SV=1 CANONICAL=F1MB08-1" }, "locus": { "chromosome": "5", "start_pos": 103545275, "end_pos": 103539159, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099120.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099120.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095891.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095891.1" } ] } }, { "isoform_ac": "A0AAA9TJG0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJG0/entry", "sequence": { "sequence": "MSILKVHAREIFDSRGNPTVEVDLFTAKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVVEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNAEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAENFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKNAIGKAGYSDKVVIGMDVAASEFYRSGKYDLDFKSPDDPSRYITPDELANLYKSFIRDYPVVSIEDPFDQDDWEAWQKFTASAGIQVVGDDLTVTNPKRIAKAVSEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILR", "length": 412, "header": "tr|A0AAA9TJG0-1|F1MB08_BOVIN Computationally mapped isoform of phosphopyruvate hydratase OS=Bos taurus OX=9913 GN=ENO1 PE=3 SV=2 CANONICAL=F1MB08-1" }, "locus": { "chromosome": "16", "start_pos": 44565143, "end_pos": 44555441, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125485.2", "url": "https://www.ensembl.org/id/ENSBTAT00000125485.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097061.2", "url": "https://www.ensembl.org/id/ENSBTAP00000097061.2" } ] } }, { "isoform_ac": "F1MB08-1", "url": "https://www.uniprot.org/uniprotkb/F1MB08/entry", "sequence": { "sequence": "MSILKVHAREIFDSRGNPTVEVDLFTAKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSRPVKYINEFLAPALCTQKLNVVEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNAEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAENFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKNAIGKAGYSDKVVIGMDVAASEFYRSGKYDLDFKSPDDPSRYITPDELANLYKSFIRDYPVVSIEDPFDQDDWEAWQKFTASAGIQVVGDDLTVTNPKRIAKAVSEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK", "length": 434, "header": "tr|F1MB08-1|F1MB08_BOVIN Isoform 1 of phosphopyruvate hydratase OS=Bos taurus OX=9913 GN=ENO1 PE=3 SV=3 CANONICAL=F1MB08-1" }, "locus": { "chromosome": "16", "start_pos": 44566421, "end_pos": 44555441, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017839.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017839.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017839.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017839.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-70171", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70171", "resource": "Reactome", "description": "Glycolysis" }, { "id": "R-BTA-70263", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70263", "resource": "Reactome", "description": "Gluconeogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B6S5-1", "protein_name": "phosphopyruvate hydratase", "gene_name": "ENO1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSILKIHAREIFDSRGNPTVEVDLHTAKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSRPVKYINEFLAPALCTQKLNVVEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNAEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAETFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKNAIGKAGYTDKVVIGMDVAASEFYRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIRDYPVVSIEDPFDQDDWEAWQKFTGSAGIQVVGDDLTVTNPKRISKAVAEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRNFRNPLAK", "length": 434 }, "evidence": [ { "id": "F1MB08", "url": "https://omabrowser.org/oma/group/F1MB08/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P00924-1", "protein_name": "Enolase 1", "gene_name": "ENO1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAVSKVYARSVYDSRGNPTVEVELTTEKGVFRSIVPSGASTGVHEALEMRDGDKSKWMGKGVLHAVKNVNDVIAPAFVKANIDVKDQKAVDDFLISLDGTANKSKLGANAILGVSLAASRAAAAEKNVPLYKHLADLSKSKTSPYVLPVPFLNVLNGGSHAGGALALQEFMIAPTGAKTFAEALRIGSEVYHNLKSLTKKRYGASAGNVGDEGGVAPNIQTAEEALDLIVDAIKAAGHDGKIKIGLDCASSEFFKDGKYDLDFKNPNSDKSKWLTGPQLADLYHSLMKRYPIVSIEDPFAEDDWEAWSHFFKTAGIQIVADDLTVTNPKRIATAIEKKAADALLLKVNQIGTLSESIKAAQDSFAAGWGVMVSHRSGETEDTFIADLVVGLRTGQIKTGAPARSERLAKLNQLLRIEEELGDNAVFAGENFHHGDKL", "length": 437 }, "evidence": [ { "id": "F1MB08", "url": "https://omabrowser.org/oma/group/F1MB08/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P04764-1", "protein_name": "Alpha-enolase", "gene_name": "Eno1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSILKIHAREIFDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDNDKTRFMGKGVSKAVEHINKTIAPALVSKKLNVVEQEKIDQLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNPEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKSAIAKAGYTDQVVIGMDVAASEFYRAGKYDLDFKSPDDASRYITPDQLADLYKSFIKDYPVVSIEDPFDQDDWDAWQKFTATAGIQVVGDDLTVTNPKRIAKAAGEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK", "length": 434 }, "evidence": [ { "id": "F1MB08", "url": "https://omabrowser.org/oma/group/F1MB08/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P06733-1", "protein_name": "Alpha-enolase", "gene_name": "ENO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK", "length": 434 }, "evidence": [ { "id": "F1MB08", "url": "https://omabrowser.org/oma/group/F1MB08/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P15007-1", "protein_name": "Enolase", "gene_name": "Eno", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSWTASVFLRTSTTSMKFLRLRWPLPRIPQNKSANVAPRFRSKSAVSQLSSGFKFVQIRKSTCDSNEMTIKAIKARQIYDSRGNPTVEVDLTTELGLFRAAVPSGASTGVHEALELRDNDKANYHGKSVLKAVGHVNDTLGPELIKANLDVVDQASIDNFMIKLDGTENKSKFGANAILGVSLAVAKAGAAKKGVPLYKHIADLAGNKEIILPVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMKMGSEVYHHLKNVIKAKFGLDATAVGDEGGFAPNIQSNKEALNLISDAIAKAGYTGKIEIGMDVAASEFYKDGQYDLDFKNEKSDKSQWLPADKLANLYQEFIKDFPIVSIEDPFDQDHWEAWSNLTGCTDIQIVGDDLTVTNPKRIATAVEKKACNCLLLKVNQIGTVTESIAAHLLAKKNGWGTMVSHRSGETEDSFIGDLVVGLSTGQIKTGAPCRSERLAKYNQILRIEEEIGAGVKFAGKSFRKPQ", "length": 500 }, "evidence": [ { "id": "F1MB08", "url": "https://omabrowser.org/oma/group/F1MB08/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P17182-1", "protein_name": "Alpha-enolase", "gene_name": "Eno1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSILRIHAREIFDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDNDKTRFMGKGVSQAVEHINKTIAPALVSKKVNVVEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNPEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKTAIAKAGYTDQVVIGMDVAASEFYRSGKYDLDFKSPDDPSRYITPDQLADLYKSFVQNYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVTNPKRIAKAASEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK", "length": 434 }, "evidence": [ { "id": "F1MB08", "url": "https://omabrowser.org/oma/group/F1MB08/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54RK5-1", "protein_name": "Enolase A", "gene_name": "enoA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSVIKSIKAREILNSRGNPTVEVDLYTEKDGVVSSFRAAVPSGASTGIYEAVELRDGDKSRYLGKGVLKAIKNILEVIQPAVIGKSVSDQAAIDKLMIDLDGTPNKGKLGANAILAVSLAVCRAGAADRNLPLYKYISEIAGTKMRLPVPAFNVINGGSHAGNKLAMQEFMILPVGAKDFNEAYRMGSEVYHNLKNVISGRYGQDAINVGDEGGFAPPIQSNKEGLELLKLAIEKAGYTGLVKIGMDCAASEFKVENGYDLDFKTKNNDGSAVISGEKLGDLYREFIKEYPIISIEDPFDQDDWESYTKLTASVDIQIVGDDLLVTNPERIKTGIEKKACNALLLKVNQIGSVTESIRAALDSKNASWGVMVSHRSGETEDTFIADLVVGLGTGQIKTGAPCRSERLAKYNQLVRINEELGENHNYAGLTFRKF", "length": 434 }, "evidence": [ { "id": "F1MB08", "url": "https://omabrowser.org/oma/group/F1MB08/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9C9C4-1", "protein_name": "Enolase 1, chloroplastic", "gene_name": "ENO1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MALTTKPHHLQRSFLSPSRVSGERYLESAPSCLRFRRSGVQCSVVAKECRVKGVKARQIIDSRGNPTVEVDLITDDLYRSAVPSGASTGIYEALELRDGDKSVYGGKGVLQAIKNINELVAPKLIGVDVRNQADVDALMLELDGTPNKSKLGANAILGVSLSVCRAGAGAKGVPLYKHIQETSGTKELVMPVPAFNVINGGSHAGNSLAMQEFMILPVGATSFSEAFQMGSEVYHTLKGIIKTKYGQDACNVGDEGGFAPNVQDNREGLVLLIDAIEKAGYTGKIKIGMDVAASEFFMKDGRYDLNFKKQPNDGAHVLSAESLADLYREFIKDFPIVSIEDPFDQDDWSSWASLQSSVDIQLVGDDLLVTNPKRIAEAIKKQSCNALLLKVNQIGTVTESIQAALDSKAAGWGVMVSHRSGETEDNFIADLSVGLASGQIKTGAPCRSERLSKYNQLLRIEEELGNVRYAGEAFRSP", "length": 477 }, "evidence": [ { "id": "F1MB08", "url": "https://omabrowser.org/oma/group/F1MB08/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "phosphopyruvate hydratase activity", "id": "GO:0004634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004634", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "GTPase binding", "id": "GO:0051020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051020", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "transcription corepressor binding", "id": "GO:0001222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001222", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "glycolytic process", "id": "GO:0006096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006096", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "positive regulation of plasminogen activation", "id": "GO:0010756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010756", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "positive regulation of muscle contraction", "id": "GO:0045933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045933", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "positive regulation of ATP biosynthetic process", "id": "GO:2001171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001171", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "response to virus", "id": "GO:0009615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009615", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "negative regulation of cell growth", "id": "GO:0030308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "canonical glycolysis", "id": "GO:0061621", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061621", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway", "id": "GO:1903298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903298", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "phosphopyruvate hydratase complex", "id": "GO:0000015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000015", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" }, { "name": "nuclear outer membrane", "id": "GO:0005640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005640", "evidence": [ { "database": "UniProtKB", "id": "F1MB08", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10164", "name": "", "equation": "(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F6RG16-1", "Q3ZC09-1", "Q9XSJ4-1", "F1MB08-1" ], "evidence": [ { "id": "10164", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10164" } ] }, { "id": "R-BTA-70494", "name": "Enolase dimers (ENO1,2,3) convert PEP to 2PG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MB08-1", "F6RG16-1", "Q3ZC09-1" ], "evidence": [ { "id": "R-BTA-70494", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70494" } ] }, { "id": "R-BTA-71660", "name": "Enolase dimers dehydrates 2PG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-30485" ], "output_participant_list": [ "R-ALL-29492" ], "enzyme_list": [ "F1MB08-1", "F6RG16-1", "Q3ZC09-1" ], "evidence": [ { "id": "R-BTA-71660", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71660" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29492", "participant_name": "PEP [cytosol]", "crossref": [ { "id": "73-89-2", "database": "CAS", "url": "" }, { "id": "c00074", "database": "KEGG Gene", "url": "" }, { "id": "PHOSPHO-ENOL-PYRUVATE", "database": "AraCyc", "url": "" }, { "id": "ZINC000003870145", "database": "ZINC", "url": "" }, { "id": "C00074", "database": "KEGG Gene", "url": "" }, { "id": "58702", "database": "ChEBI", "url": "" }, { "id": "3674425", "database": "PubChem Compound", "url": "" }, { "id": "138-08-9", "database": "CAS", "url": "" } ] }, { "participant_id": "R-ALL-30485", "participant_name": "2PG [cytosol]", "crossref": [ { "id": "58289", "database": "ChEBI", "url": "" }, { "id": "ZINC000003869232", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F1MB08", "gene_name": "ENO1", "activity": [ { "ec_number": "4.2.1.11", "activity": "(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O.", "evidence": [ { "id": "F1MB08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ] }, { "ec_number": "4.2.1.11", "activity": "", "evidence": [ { "id": "F1MB08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB08" } ] } ] }, { "uniprot_ac": "F6RG16", "gene_name": "ENO4", "activity": [ { "ec_number": "4.2.1.11", "activity": "(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O.", "evidence": [ { "id": "F6RG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG16" } ] }, { "ec_number": "4.2.1.11", "activity": "", "evidence": [ { "id": "F6RG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG16" } ] } ] }, { "uniprot_ac": "Q3ZC09", "gene_name": "ENO3", "activity": [ { "ec_number": "4.2.1.11", "activity": "(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O.", "evidence": [ { "id": "Q3ZC09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC09" } ] }, { "ec_number": "4.2.1.11", "activity": "", "evidence": [ { "id": "Q3ZC09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZC09" } ] } ] }, { "uniprot_ac": "Q9XSJ4", "gene_name": "ENO1", "activity": [ { "ec_number": "4.2.1.11", "activity": "(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O.", "evidence": [ { "id": "Q9XSJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSJ4" } ] }, { "ec_number": "4.2.1.11", "activity": "", "evidence": [ { "id": "Q9XSJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSJ4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { 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[], "enzyme_annotation": [ { "ec_number": "4.2.1.11", "ec_name": "(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O.", "evidence": [ { "id": "4.2.1.11", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.11" }, { "id": "4.2.1.11", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.2.1.11" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E3W9A0-1", "uniprot_ac": "E3W9A0", "uniprot_id": "E3W9A0_BOVIN", "mass": { "chemical_mass": 154697.0, "monoisotopic_mass": 154697.0 }, "refseq": {}, "gene_names": [ { "name": "WC1", "type": "recommended", "evidence": [ { "id": "E3W9A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E3W9A0" } ] } ], "protein_names": [ { "name": "BoWC1.1", "type": "synonym", "evidence": [ { "id": "E3W9A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E3W9A0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E3W9A0", "url": "https://www.uniprot.org/uniprotkb/E3W9A0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WC1", "url": "https://www.uniprot.org/uniprotkb/E3W9A0", "locus": { "chromosome": "5", "start_pos": 102767946, "end_pos": 102819482, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000049861", "url": "https://www.ensembl.org/id/ENSBTAG00000049861" } ] } } ], "crossref": [ { "id": "ENSBTAG00000049861", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000049861", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RIGDNTH", "url": "https://omabrowser.org/oma/group/RIGDNTH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR19331", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19331", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19331:SF468", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19331:SF468", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48071", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48071", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48071:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48071:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00530", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00530", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MZY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MZY9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N0Z7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0Z7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N0Z7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0Z7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E3W9A0", "url": "https://www.uniprot.org/uniprotkb/E3W9A0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E3W9A0-1", "url": "https://www.uniprot.org/uniprotkb/E3W9A0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9QB09", "url": "https://www.uniprot.org/uniprotkb/E9QB09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9QB09-1", "url": "https://www.uniprot.org/uniprotkb/E9QB09-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALGRHLSLRGLCVLLLGTVVGGQALELRLKDGVHRCEGRVEVKHQGEWGTVDGYRWTLKDASVVCRQLGCGAAIGFPGGAYFGPGLGPIWLLYTSCEGTESTVSDCEHSNIKDYRNDGYNHGRDAGVVCSGFVRLAGGDEPCSGRVEVYSGEAWIPVSDGNFTLPTAQVICAELGCGKAVSVQGHELFRESSARVWAEEFRCEGEEPELSVCLRVPCPGGTCHHSGAAQVVCSAYSEVRLMTNGSSQCEGQVEMKFSGRWRALCASHWSLANANVVCRQLGCGVAISTPGGPHLVEGGDQILTARFHCSGAESFLWSCPVTALGGPDCSHGNTASVICSGNQTQVLPQCNNSMAEPAGSAASVESAPYCSDSRQLRVVGGASPCAGRVEIFDQGSWGTICDDGWDLDDAHVVCRQLGCGEALNATGSAHFGAGSGPIWLDDLNCTGKESHVWRCPSRGWGRHDCRHKQDAGVICSEFLALRMVNEDQQCAGWLEVFYNGTWGSVCRSPMEDITVSVICRQLGCGDSGSLNSSVGLREGSRPRWVDGIRCQKTDTSLWQCPSDPWNYTSCSPKEEAYISCADSRQLRLVDGGSHCAGRVEILNQGSWGTICDYSWDLDDARVVCRQLGCGKALDATLSSSFGAGSGPIWLDNVRCTGKESHVWRCPSRDWGKHYCDHSQDAGVICSGFLRLAGGDGPCSGRVEVHSGEAWIPVSDGNFTLPTAQVICAELGCGKAVSVLGHVPFRESNARVWAEEFRCEGEEPELRVCPRVPCPGGTCHHSGAVQVVCSVYTDVRLMTNGSSQCEGQVEMNIFGQWRALCASHWSLANANVVCRQLGCGVAVSTPNRAEGSDQLWKARFHCSGTESFLWTCPVTTLGVPDCSHGNTASVMCSGNQTQVLPQCDHFVSEPAGSAASEERAPYCSDSRQLRLVDGGSHCAGRVEILDQGSWGTICDDGWDLDDARVVCRQLGCGEALNATGSAHFGAGSGPIWLDDLNCAGNESQVWTCPSPRGWGRHDCRHKEDAGVICSEFLALRMVSEDQQCAGWLEVFYNGTWGSVCRSPMEDITVSVICRQLGCGDSGSLNTSVGLREGSRPQWVDLIQCRKMDTSLWQCPSGPWKYSSCSPKEEAYISCAGRRPKSCPTAAPCTDREKLRLRGGDSKCSGRVEVWHSGSWGTVCDDSWSLAEAEVVCQQLGCGQALEAVQSAAFGPGNGSIWLDEVRCGGRESSLWDCAAEPWGQSDCKHEEDAGVRCSGVRTTVPTTTAGTRTTSNSLPGIFSLPGILCVILGALLFLVLVILMTQLLRWRAERRALSSYEDALAEAVYEELDYLLTQKEGLGSPDQRTDVPAENYDDAEEVPVPGTPSASQGNEEEVPPEKEDGVRSSQTGSYLNFSREAADPGEGEESLWLFQGKNEDAGYDDVELSALGTSPVTFCDAVLTRR", "length": 1441, "header": "tr|E3W9A0-1|E3W9A0_BOVIN Isoform 1 of BoWC1.1 OS=Bos taurus OX=9913 GN=WC1 PE=4 SV=4 CANONICAL=E3W9A0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MZY9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZY9/entry", "sequence": { "sequence": "MALGRHLSLQGLCVLLLGTMVGGQVLELRLKDGAHRCEGRVEVKHQGEWGTVDDLEWTLKDASVVCRQLGCGAAIGFPGGAYFGPGLGPIWLSYTSCEGVESTVSDCRHSNIKDYRNDSYLHDWDAGVVCSGFVRLAGGDEPCSGRVEVYSGEAWIPVSDGNFTLPTAQVICAELGCGKAVSVQGHELFRESSARVWAEEFRCEGEEPELSVCLRVPCPGGTCHHSGAAQVVCSAYSEVRLMTNGSSQCEGQVEMKFSGRWRALCASHWSLANANVVCRQLGCGVAISTPGGPHLVEGGDQILTARFHCSGAESFLWSCPVTALGGPDCSHGNTASVICSGNQTQVLPQCNNSMAEPAGSAASVESAPYCSDSRQLRVVGGASPCAGRVEIFDQGSWGTICDDGWDLDDAHVVCRQLGCGEALNATGSAHFGAGSGPIWLDDLNCAGNESQVWTCPSPRGWGRHDCRHKEDAGVICSEFLALRMVSEDQQCAGWLEVFYNGTWGSVCRSPMEDITVSVICRQLGCGDSGSLNTSVGLREGSRPQWVDLIQCRKMDTSLWQCPSGPWKYSSCSPKEEAYISCAGRRPKSCPTAAPCTDREKLRLRGGDSKCSGRVEVWHSGSWGTVCDDSWSLAEAEVVCQQLGCGQALEAVQSAAFGPGNGSIWLDEVRCGGRESSLWDCAAEPWGQSDCKHEEDAGVRCSGVRTTVPTTTAGTRTTSNSLPGIFSLPGILCVILGALLFLVLVILMTQLLRWRAERRALSSYEDALAEAVYEELDYLLTQKEGLGSPDQRTDVPAENYDDAEEVPVPGTPSASQGNEEEVPPEKEDGVRSSQTGSYLNFSREAADPGEGEESLWLFQGKNEDAGYDDVELSALGTSPVTF", "length": 881, "header": "tr|A0A3Q1MZY9-1|E3W9A0_BOVIN Computationally mapped isoform of BoWC1.1 OS=Bos taurus OX=9913 GN=WC1 PE=4 SV=2 CANONICAL=E3W9A0-1" }, "locus": { "chromosome": "5", "start_pos": 102819373, "end_pos": 102768114, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072175.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072175.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061881.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061881.2" } ] } }, { "isoform_ac": "A0A3Q1N0Z7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N0Z7/entry", "sequence": { "sequence": "MALGRHLSLRGLCVLLLGTVVGGQALELRLKDGVHRCEGRVEVKHQGEWGTVDGYRWTLKDASVVCRQLGCGAAIGFPGGAYFGPGLGPIWLLYTSCEGTESTVSDCEHSNIKDYRNDGYNHGRDAGVVCSGFVRLAGGDGPCSGRVEVHSGEAWIPVSDGNFTLATAQIICAELGCGKAVSVLGHELFRESSAQVWAEEFRCEGEEPELWVCPRVPCPGGTCHHSGSAQVVCSAYSEVRLMTNGSSQCEGQVEMNISGQWRALCASHWSLANANVICRQLGCGVAISTPGGPHLVEEGDQILTARFHCSGAESFLWSCPVTVLGGPDCSHGNTASVICSGNQIQVLPQCNDSVSQPTGSAASEDSAPYCSDSRQLRLVDGGGPCAGRVEILDQGSWGTICDDGWDLDDARVVCRQLGCGEALNATGSAHFGAGSGPIWLDNLNCTGKESHVWRCPSRGWGQHNCRHKQDAGVICSEFLALRMVSEDQQCAGWLEVFYNGTWGSVCRNPMEDITVSTICRQLGCGDSGTLNSSVALREGFRPQWVDRIQCRKTDTSLWQCPSDPWNYNSCSPKEEAYIWCADSRQIRLVDGGGRCSGRVEILDQGSWGTICDDRWDLDDARVVCKQLGCGEALDATVSSFFGTGSGPIWLDEVNCRGEESQVWRCPSWGWRQHNCNHQEDAGVICSGFVRLAGGDGPCSGRVEVHSGEAWTPVSDGNFTPPTAQVICAELGCGKAVSVLGHMPFRESDGQVWAEEFRCDGGEPELWSCPRVPCPGGTCLHSGAAQVVCSVYTEVQLMKNGTSQCEGQVEMKISGRWRALCASHWSLANANVVCRQLGCGVAISTPRGPHLVEGGDQISTAQFHCSGAESYLWSCPVTALGGPDCSHGNTASVICSGNQTQVLPQCNNSMAEPAGSAASVESAPYCSDSRQLRVVGGASPCAGRVEIFDQGSWGTICDDGWDLDDAHVVCRQLGCGEALNATGSAHFGAGSGPIWLDDLNCTGKESHVWRCPSRGWGRHDCRHKQDAGVICSEFLALRMVSEDQQCAGWLEVFYNGTWGSVCRSPMEDITVSVICRQLGCGDSGSLNTSVGLREGSRPQWVDLIQCRKMDTSLWQCPSGPWKYSSCSPKEEAYISCAGRRPKSCPTAAPCTDREKLRLRGGDSKCSGRVEVWHSGSWGTVCDDSWSLAEAEVVCQQLGCGQALEAVQSAAFGPGNGSIWLDEVRCGGRESSLWDCAAEPWGQSDCKHEEDAGVRCSGVRTTVPTTTAGTRTTSNSLPGIFSLPGILCVILGALLFLVLVILMTQLLRWRAERRALSSYEDALAEAVYEELDYLLTQKEGLGSPDQRTDVPAENYDDAEEVPVPGTPSASQGNEEEVPPEKEDGVRSSQTGE", "length": 1390, "header": "tr|A0A3Q1N0Z7-1|E3W9A0_BOVIN Computationally mapped isoform of BoWC1.1 OS=Bos taurus OX=9913 GN=WC1 PE=4 SV=3 CANONICAL=E3W9A0-1" }, "locus": { "chromosome": "5", "start_pos": 103003566, "end_pos": 102771451, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083413.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083413.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062530.3", "url": "https://www.ensembl.org/id/ENSBTAP00000062530.3" } ] } }, { "isoform_ac": "E3W9A0-1", "url": "https://www.uniprot.org/uniprotkb/E3W9A0/entry", "sequence": { "sequence": "MALGRHLSLRGLCVLLLGTVVGGQALELRLKDGVHRCEGRVEVKHQGEWGTVDGYRWTLKDASVVCRQLGCGAAIGFPGGAYFGPGLGPIWLLYTSCEGTESTVSDCEHSNIKDYRNDGYNHGRDAGVVCSGFVRLAGGDEPCSGRVEVYSGEAWIPVSDGNFTLPTAQVICAELGCGKAVSVQGHELFRESSARVWAEEFRCEGEEPELSVCLRVPCPGGTCHHSGAAQVVCSAYSEVRLMTNGSSQCEGQVEMKFSGRWRALCASHWSLANANVVCRQLGCGVAISTPGGPHLVEGGDQILTARFHCSGAESFLWSCPVTALGGPDCSHGNTASVICSGNQTQVLPQCNNSMAEPAGSAASVESAPYCSDSRQLRVVGGASPCAGRVEIFDQGSWGTICDDGWDLDDAHVVCRQLGCGEALNATGSAHFGAGSGPIWLDDLNCTGKESHVWRCPSRGWGRHDCRHKQDAGVICSEFLALRMVNEDQQCAGWLEVFYNGTWGSVCRSPMEDITVSVICRQLGCGDSGSLNSSVGLREGSRPRWVDGIRCQKTDTSLWQCPSDPWNYTSCSPKEEAYISCADSRQLRLVDGGSHCAGRVEILNQGSWGTICDYSWDLDDARVVCRQLGCGKALDATLSSSFGAGSGPIWLDNVRCTGKESHVWRCPSRDWGKHYCDHSQDAGVICSGFLRLAGGDGPCSGRVEVHSGEAWIPVSDGNFTLPTAQVICAELGCGKAVSVLGHVPFRESNARVWAEEFRCEGEEPELRVCPRVPCPGGTCHHSGAVQVVCSVYTDVRLMTNGSSQCEGQVEMNIFGQWRALCASHWSLANANVVCRQLGCGVAVSTPNRAEGSDQLWKARFHCSGTESFLWTCPVTTLGVPDCSHGNTASVMCSGNQTQVLPQCDHFVSEPAGSAASEERAPYCSDSRQLRLVDGGSHCAGRVEILDQGSWGTICDDGWDLDDARVVCRQLGCGEALNATGSAHFGAGSGPIWLDDLNCAGNESQVWTCPSPRGWGRHDCRHKEDAGVICSEFLALRMVSEDQQCAGWLEVFYNGTWGSVCRSPMEDITVSVICRQLGCGDSGSLNTSVGLREGSRPQWVDLIQCRKMDTSLWQCPSGPWKYSSCSPKEEAYISCAGRRPKSCPTAAPCTDREKLRLRGGDSKCSGRVEVWHSGSWGTVCDDSWSLAEAEVVCQQLGCGQALEAVQSAAFGPGNGSIWLDEVRCGGRESSLWDCAAEPWGQSDCKHEEDAGVRCSGVRTTVPTTTAGTRTTSNSLPGIFSLPGILCVILGALLFLVLVILMTQLLRWRAERRALSSYEDALAEAVYEELDYLLTQKEGLGSPDQRTDVPAENYDDAEEVPVPGTPSASQGNEEEVPPEKEDGVRSSQTGSYLNFSREAADPGEGEESLWLFQGKNEDAGYDDVELSALGTSPVTFCDAVLTRR", "length": 1441, "header": "tr|E3W9A0-1|E3W9A0_BOVIN Isoform 1 of BoWC1.1 OS=Bos taurus OX=9913 GN=WC1 PE=4 SV=4 CANONICAL=E3W9A0-1" }, "locus": { "chromosome": "5", "start_pos": 103003566, "end_pos": 102768090, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000028129.8", "url": "https://www.ensembl.org/id/ENSBTAT00000028129.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000028129.7", "url": "https://www.ensembl.org/id/ENSBTAP00000028129.7" } ] } }, { "isoform_ac": "E9QB09-1", "url": "https://www.uniprot.org/uniprotkb/E9QB09/entry", "sequence": { "sequence": "MALGRHLSLRGLCVLLLGTVVGGQALELRLKDGAHRCEGRVEVKHQGEWGTVNDYNLIMEDASVVCRQLGCGAAIGFPGKAYFGPGLGPIWLLYTSCEGTESTVSDCEHSNIKDYRNDSYSHDDDAGVVCSGFVHLAGGVGPCSGRVEVHSGEAWTPVSDGNFTLPTAQVICAELGCGKAVSVLGHVPFRESDRWVWAEEFRCEGEEPELWSCPRVPCPGGTCHHSGAAQVVCSVYTEVRLMKNGTSQCEGQVEMNISGHWRALCASHWSLANANVVCRQFGCGVAISTPNGAEGSDQLWKAFHCSGAESFLWKCPVTALGVPDCSRGNTASVICSGNHTQMLPQCNNSVSEQAGSAASEESAPYCSDSRQLRLVDGGGPCAGRVEILDQGSWGTICDDYWDLDDAHVVCRQLGCGEALNATGSAHFRAGSGPIWLDDLNCTGKESHVWRCPSRGWGRHDCRHKEDAGVICSEFLALRMVSEDQQCAGCLEVFYNGTWGSVCCSPMKDITVSMICSQLGCGDSGSLNTSVGLREGSRPRWVDLIQCRKTDTSLWQCPSGPWKYSSCSPKEEAYISCADSRQLRLVDGGSHCAGRVEILNQGSWGTICDYSWDLDDARVVCRQLGCGKALDATLSSSFGAGSGPIWLDNVRCTGKESHVWRCPSRDWGKHYCDHSQDAGVICSGFLRLAGGDGPCSGRVEVHSGEAWIPVSDGNFTLPTAQVICAELGCGKAVSVLGHVPFRESNARVWAEEFRCEGEEPELRVCPRVPCPGGTCHHSGAVQVVCSVYTDVRLMTNGSSQCEGQVEMNIFGQWRALCASHWSLANANVVCRQLGCGVAVSTPNRAEGSDQLWKARFHCSGTESFLWTCPVTTLGVPDCSHGNTASVMCSDQTQVLPQCDHFVSEPAGSAASEERAPYCSDSRQLRLVDGGSHCAGRVEILDQGSWGTICDDGWDLDDARVVCRQLGCGEALNATGSAHFGAGSGPIWLDDLNCAGNESQVWTCPSPRGWGRHDCRHKEDAGVICSEFLALRMVSEDQQCAGWLEVFYNGTWGSVCRSPMEDITVSVICRQLGCGDSGSLNTSVGLREGSRPQWVDLIQCRKMDTSLWQCPSGPWKYSSCSPKEEAYISCAGRRPKSCPTAAPCTDREKLRLRGGDSKCSGRVEVWHSGSWGTVCDDSWSLAEAEVVCQQLGCGQALEAVQSAAFGPGNGSIWLDEVRCGGRESSLWDCAAEPWGQSDCKHEEDAGVRCSDYLQPFFLFSLGTRTTSNSLPGIFSLPGILCVILGALLFLVLVILMTQLLRWRAERRALSSYEDALAEAVYEELDYLLTQKEGLGSPDQRTDVPAENYDDAEEVPVPGTPSASQGNEEEVPPEKEDGVRSSQTGSYLNFSREAADPGEGEESLWLFQGKNEDAGYDDVELSALGTSPVTF", "length": 1428, "header": "tr|E9QB09-1|E9QB09_BOVIN Computationally mapped isoform of BoWC1.1 OS=Bos taurus OX=9913 GN=WC1 PE=4 SV=5 CANONICAL=E3W9A0-1" }, "locus": { "chromosome": "5", "start_pos": 103003566, "end_pos": 102768114, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000057422.5", "url": "https://www.ensembl.org/id/ENSBTAT00000057422.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051763.5", "url": "https://www.ensembl.org/id/ENSBTAP00000051763.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1362, "start_aa": "Thr", "end_pos": 1362, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1362", "evidence": [ { "id": "", "database": 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"Protein" ] }, { "id": "F1MIH9", "url": "https://www.uniprot.org/uniprotkb/F1MIH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIH9-1", "url": "https://www.uniprot.org/uniprotkb/F1MIH9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVAPMYGSPGGRLARAVTRALALALVLALLVGLFLSGLTGAIPTPRGQRGRGMPVPPASRCRSLLLDPETGQLRLVDGRHPDAVAWANLTNAIRETGWAFLELHTNGRFNDSLQAYAAGVVEAAVSEELIYMYWMNTVVNYCGPFEYEVGYCERLKNFLEANLEWMQKEMELNNGSAYWHQVRLTLLQLKGLEDSYEGSVAFPTGKFTVKPLGFLLLQISGDLEDLEVALNKTKTNHAMGSGSCSALIKLLPGQRDLLVAHNTWHSYQYMLRIMKKYWFQFREGPQAESTRAPGNKVIFSSYPGTIFSCDDFYILGSGLVTLETTIGNKNPALWKYVQPTGCVLEWMRNVVANRLALDGDSWADIFKRFNSGTYNNQWMIVDYKAFVPGGPSPGRRVLTVLEQIPGMVVVADRTSELYQKTYWASYNIPSFESVFNASGLPALVARYGPWFSYDGSPRAQIFRRNHSLVHDLDSMMRLMRYNDFLHDPLSLCKACTPKPNGENAISARSDLNPANGSYPFQALHQRSHGGIDVKVTSTALAKALRLLAVSGPTWDQLPPFQWSTSPFSGMLHMGQPDLWKFSPIEVSWD", "length": 589, "header": "tr|F1MIH9-1|F1MIH9_BOVIN Isoform 1 of Phospholipase B domain containing 2 OS=Bos taurus OX=9913 GN=PLBD2 PE=4 SV=2 CANONICAL=F1MIH9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N1J5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1J5/entry", "sequence": { "sequence": "MVAPMYGSPGGRLARAVTRALALALVLALLVGLFLSGLTGAIPTPRGQRGRGMPVPPASRCRSLLLDPETGQLRLVDGRHPDAVAWANLTNAIRETGWAFLELHTNGRFNDSLQAYAAGVVEAAVSEELIYMYWMNTVVNYCGPFEYEVGYCERLKNFLEANLEWMQKEMELNNGSAYWHQVRLTLLQLKGLEDSYEGSVAFPTGKFTVKPLGFLLLQISGDLEDLEVALNKTKTNHAMGSGSCSALIKLLPGQRDLLVAHNTWHSYQYMLRIMKKYWFQFREGPQAESTRAPGNKVIFSSYPGTIFSCDDFYILGSGLTLRNLFLAPLVDFSKPCGHQGNPAEEKKTSLKKQPRSRRHQFLVTLETTIGNKNPALWKYVQPTGCVLEWMRNVVANRLALDGDSWADIFKRFNSGTYNNQWMIVDYKAFVPGGPSPGRRVLTVLEQIPGMVVVADRTSELYQKTYWASYNIPSFESVFNASGLPALVARYGPWFSYDGSPRAQIFRRNHSLVHDLDSMMRLMRYNDFLHDPLSLCKACTPKPNGENAISARSDLNPANGSYPFQALHQRSHGGIDVKVTSTALAKALRLLAVSGPTWDQLPPFQWSTSPFSGMLHMGQPDLWKFSPIEVSWD", "length": 632, "header": "tr|A0A3Q1N1J5-1|F1MIH9_BOVIN Computationally mapped isoform of Phospholipase B domain containing 2 OS=Bos taurus OX=9913 GN=PLBD2 PE=4 SV=1 CANONICAL=F1MIH9-1" }, "locus": { "chromosome": "17", "start_pos": 61063667, "end_pos": 61042086, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085887.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085887.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062939.1", "url": "https://www.ensembl.org/id/ENSBTAP00000062939.1" } ] } }, { "isoform_ac": "A0AAA9SHB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHB7/entry", "sequence": { "sequence": "MVAPMYGSPGGRLARAVTRALALALVLALLVGLFLSGLTGAIPTPRGQRGRGMPVPPASRCRSLLLDPETGQLRLVDGRHPDAVAWANLTNAIRETGWAFLELHTNGRFNDSLQAYAAGVVEAAVSEELIYMYWMNTVVNYCGPFEYEVGYCERLKNFLEANLEWMQKEMELNNGSAYWHQVRLTLLQLKGLEDSYEGSVAFPTGKFTVKPLGFLLLQISGDLEDLEVALNKTKTNHAMGSGSCSALIKLLPGQRDLLVAHNTWHSYQYMLRIMKKYWFQFREGPQAESTRAPGNKVIFSSYPGTIFSCDDFYILGSGLVTLETTIGNKNPALWKYVQPTGCVLEWMRNVVANRLALDGDSWADIFKRFNSGTGMVVVADRTSELYQKTYWASYNIPSFESVFNASGLPALVARYGPWFSYDGSPRAQIFRRNHSLVHDLDSMMRLMRYNDFLHDPLSLCKACTPKPNGENAISARSDLNPANGSYPFQALHQRSHGGIDVKVTSTALAKALRLLAVSGPTWDQLPPFQWSTSPFSGMLHMGQPDLWKFSPIEVSWD", "length": 557, "header": "tr|A0AAA9SHB7-1|F1MIH9_BOVIN Computationally mapped isoform of Phospholipase B domain containing 2 OS=Bos taurus OX=9913 GN=PLBD2 PE=4 SV=1 CANONICAL=F1MIH9-1" }, "locus": { "chromosome": "17", "start_pos": 61063667, "end_pos": 61042086, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100991.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100991.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083103.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083103.1" } ] } }, { "isoform_ac": "F1MIH9-1", "url": "https://www.uniprot.org/uniprotkb/F1MIH9/entry", "sequence": { "sequence": "MVAPMYGSPGGRLARAVTRALALALVLALLVGLFLSGLTGAIPTPRGQRGRGMPVPPASRCRSLLLDPETGQLRLVDGRHPDAVAWANLTNAIRETGWAFLELHTNGRFNDSLQAYAAGVVEAAVSEELIYMYWMNTVVNYCGPFEYEVGYCERLKNFLEANLEWMQKEMELNNGSAYWHQVRLTLLQLKGLEDSYEGSVAFPTGKFTVKPLGFLLLQISGDLEDLEVALNKTKTNHAMGSGSCSALIKLLPGQRDLLVAHNTWHSYQYMLRIMKKYWFQFREGPQAESTRAPGNKVIFSSYPGTIFSCDDFYILGSGLVTLETTIGNKNPALWKYVQPTGCVLEWMRNVVANRLALDGDSWADIFKRFNSGTYNNQWMIVDYKAFVPGGPSPGRRVLTVLEQIPGMVVVADRTSELYQKTYWASYNIPSFESVFNASGLPALVARYGPWFSYDGSPRAQIFRRNHSLVHDLDSMMRLMRYNDFLHDPLSLCKACTPKPNGENAISARSDLNPANGSYPFQALHQRSHGGIDVKVTSTALAKALRLLAVSGPTWDQLPPFQWSTSPFSGMLHMGQPDLWKFSPIEVSWD", "length": 589, "header": "tr|F1MIH9-1|F1MIH9_BOVIN Isoform 1 of Phospholipase B domain containing 2 OS=Bos taurus OX=9913 GN=PLBD2 PE=4 SV=2 CANONICAL=F1MIH9-1" }, "locus": { "chromosome": "17", "start_pos": 61063667, "end_pos": 61042086, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025343.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025343.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025343.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025343.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 18, "start_aa": "Thr", "end_pos": 18, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr18", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1P0Z3-1", "protein_name": "Phospholipase B-like", "gene_name": "PLBD2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAALRALLAAAAVAAWVLGVASGPTPPPRSASVLLEPGSGRLRVLPGRQPAAVAWAELTDHIQAVGWAFLEVSANASFNDSLQAYAAGLAEAAVTEQLIYMHWMNTAVGYCGPFRYETQYCRRLRGYLEANLAWMEEQMASGRDRAYWHQVRLALLQLQGLEDSYRGRVALPAGRISLSPFGFLLLQLGGDLEDLEAAFNRSAPRRLLGSGSCSALLKLLPGRRDLLVAHDTWAPYQSMLRVIKKYTLPFRTEPGSTARVPGSIQVFSSYPGTIFSGDDFYILSSGLVALETTIGNSDEARWRYLRPQGSVLEWLRNIVANRLARSGAEWASIFQRFNSGTYNNQWMLVDYKAFSPGQAAPQQGLLTVLEQIPGLVMVADKTELLYKQGYWASYNVPYFEEIFNASGNLELVQKYGDWFTYDKNPRAQIFRRNETQVHDVDSMVRLMRSNNYLQDPLSQCQGCNPPHNAENAISARSDLNPANGTYPFAALRQRCHGGTDTKVTSFGMARTFGLVAASGPTWDDVPPFRWSTSPCSHLLRMGHPDLWRFPPVKVRWD", "length": 557 }, "evidence": [ { "id": "F1MIH9", "url": "https://omabrowser.org/oma/group/F1MIH9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3I6T1-1", "protein_name": "Phospholipase B-like 2", "gene_name": "Plbd2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAPMDRSPGGRAVRALRLALALASLTEVLLNCPAGALPTQGPGRRRQNLDPPVSRVRSVLLDAASGQLRLVDGIHPYAVAWANLTNAIRETGWAYLDLGTNGSYNDSLQAYAAGVVEASVSEELIYMHWMNTMVNYCGPFEYEVGYCEKLKSFLEINLEWMQREMELSQDSPYWHQVRLTLLQLKGLEDSYEGRLTFPTGRFTIKPLGFLLLQIAGDLEDLEQALNKTSTKLSLGSGSCSAIIKLLPGARDLLVAHNTWNSYQNMLRIIKKYQLQFRQGPQEAYPLIAGNNLVFSSYPGTIFSGDDFYILGSGLVTLETTIGNKNPALWKYVQPQGCVLEWIRNIVANRLALDGATWADIFKQFNSGTYNNQWMIVDYKAFIPNGPSPGSRVLTILEQIPGMVVVADKTEDLYKTTYWASYNIPFFEIVFNASGLQDLVAQYGDWFSYTKNPRAQIFQRDQSLVEDMNSMVRLIRYNNFLHDPLSLCEACIPKPNAENAISARSDLNPANGSYPFQALYQRPHGGIDVKVTSFSLAKRMSMLAASGPTWDQLPPFQWSLSPFRSMLHMGQPDLWTFSPISVPWD", "length": 585 }, "evidence": [ { "id": "F1MIH9", "url": "https://omabrowser.org/oma/group/F1MIH9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3TCN2-1", "protein_name": "Putative phospholipase B-like 2", "gene_name": "Plbd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAPVDGSSGGWAARALRRALALTSLTTLALLASLTGLLLSGPAGALPTLGPGWQRQNPDPPVSRTRSLLLDAASGQLRLEDGFHPDAVAWANLTNAIRETGWAYLDLSTNGRYNDSLQAYAAGVVEASVSEELIYMHWMNTVVNYCGPFEYEVGYCEKLKNFLEANLEWMQREMELNPDSPYWHQVRLTLLQLKGLEDSYEGRLTFPTGRFTIKPLGFLLLQISGDLEDLEPALNKTNTKPSLGSGSCSALIKLLPGGHDLLVAHNTWNSYQNMLRIIKKYRLQFREGPQEEYPLVAGNNLVFSSYPGTIFSGDDFYILGSGLVTLETTIGNKNPALWKYVQPQGCVLEWIRNVVANRLALDGATWADVFKRFNSGTYNNQWMIVDYKAFLPNGPSPGSRVLTILEQIPGMVVVADKTAELYKTTYWASYNIPYFETVFNASGLQALVAQYGDWFSYTKNPRAKIFQRDQSLVEDMDAMVRLMRYNDFLHDPLSLCEACNPKPNAENAISARSDLNPANGSYPFQALHQRAHGGIDVKVTSFTLAKYMSMLAASGPTWDQCPPFQWSKSPFHSMLHMGQPDLWMFSPIRVPWD", "length": 594 }, "evidence": [ { "id": "F1MIH9", "url": "https://omabrowser.org/oma/group/F1MIH9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q4QQW8-1", "protein_name": "Putative aminopeptidase PLBD2", "gene_name": "Plbd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAPMDRTHGGRAARALRRALALASLAGLLLSGLAGALPTLGPGWRRQNPEPPASRTRSLLLDAASGQLRLEYGFHPDAVAWANLTNAIRETGWAYLDLGTNGSYNDSLQAYAAGVVEASVSEELIYMHWMNTVVNYCGPFEYEVGYCEKLKSFLEANLEWMQREMELSPDSPYWHQVRLTLLQLKGLEDSYEGRLTFPTGRFNIKPLGFLLLQISGDLEDLEPALNKTNTKPSVGSGSCSALIKLLPGSHDLLVAHNTWNSYQNMLRIIKKYRLQFREGPQEEYPLIAGNNLIFSSYPGTIFSGDDFYILGSGLVTLETTIGNKNPALWKYVQPQGCVLEWIRNIVANRLALDGATWADVFRRFNSGTYNNQWMIVDYKAFIPNGPSPGSRVLTILEQIPGMVVVADKTAELYKTTYWASYNIPYFESVFNASGLQALVAQYGDWFSYTRNPRAKIFQRDQSLVEDVDTMVRLMRYNDFLHDPLSLCEACSPKPNAENAISARSDLNPANGSYPFQALRQRAHGGIDVKVTSVALAKYMSMLAASGPTWDQLPPFQWSKSPFHNMLHMGQPDLWMFSPVKVPWD", "length": 585 }, "evidence": [ { "id": "F1MIH9", "url": "https://omabrowser.org/oma/group/F1MIH9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q55BJ6-1", "protein_name": "Phospholipase B-like protein B", "gene_name": "plbB", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNKLKSNFILNIVILFTILIFNINFINCENQKQQQHQQQQQQQQQQSSSTTTTLPIYSIKFSSETGFTIYSGNDSTSIAQSGFSNEMMTMGWAYLTITTNSQFEDSLQAEAAGYIEGYLTFEMIWQCWYNILVNEYQNQTIPNQVLNWANENIAYMKQQVATNENDPYWINIGLVLTQLSGMVDGYNAANQDPSRQLSFLDFILINMDADLGDISSTFNQSTSFSEISNFKKSMDHIKKTDHCSGLIKLTDDLTELYSAHTSWSSYINMLRIFKSYNFKFSSITNIKSKLTLFSGYPATIASLDDFYLLDTKLVVLETTNGLNNNDLYYLIKPESVLTWMRVIIANRLANGGQSWCETFERENSGTYNNQWMIVDYNKFVPGVKVRDGTLFVLEQVPGYIEFADVTNVLRTGYWPSYNIPYFETIFNMSGFNDELTDSSDYEAYEEDARSQIFRRDANKVYSLTDFQAIMRYNNFQNDPLSHGDAANQISSRFDLNSPDSQDYDAFGGVDSKVTSFSLVNQLLVIAQSGPTHDQEPPFQWSSANWSNIYPSIGMPNLYDFGWVNFTDISYNY", "length": 572 }, "evidence": [ { "id": "F1MIH9", "url": "https://omabrowser.org/oma/group/F1MIH9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8NHP8-1", "protein_name": "Putative aminopeptidase PLBD2", "gene_name": "PLBD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVGQMYCYPGSHLARALTRALALALVLALLVGPFLSGLAGAIPAPGGRWARDGQVPPASRSRSVLLDVSAGQLLMVDGRHPDAVAWANLTNAIRETGWAFLELGTSGQYNDSLQAYAAGVVEAAVSEELIYMHWMNTVVNYCGPFEYEVGYCERLKSFLEANLEWMQEEMESNPDSPYWHQVRLTLLQLKGLEDSYEGRVSFPAGKFTIKPLGFLLLQLSGDLEDLELALNKTKIKPSLGSGSCSALIKLLPGQSDLLVAHNTWNNYQHMLRVIKKYWLQFREGPWGDYPLVPGNKLVFSSYPGTIFSCDDFYILGSGLVTLETTIGNKNPALWKYVRPRGCVLEWVRNIVANRLASDGATWADIFKRFNSGTYNNQWMIVDYKAFIPGGPSPGSRVLTILEQIPGMVVVADKTSELYQKTYWASYNIPSFETVFNASGLQALVAQYGDWFSYDGSPRAQIFRRNQSLVQDMDSMVRLMRYNDFLHDPLSLCKACNPQPNGENAISARSDLNPANGSYPFQALRQRSHGGIDVKVTSMSLARILSLLAASGPTWDQVPPFQWSTSPFSGLLHMGQPDLWKFAPVKVSWD", "length": 589 }, "evidence": [ { "id": "F1MIH9", "url": "https://omabrowser.org/oma/group/F1MIH9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phospholipase activity", "id": "GO:0004620", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004620", "evidence": [ { "database": "UniProtKB", "id": "F1MIH9", "url": "https://www.uniprot.org/uniprotkb/F1MIH9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "F1MIH9", "url": "https://www.uniprot.org/uniprotkb/F1MIH9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MIH9", "url": "https://www.uniprot.org/uniprotkb/F1MIH9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 436, "end_pos": 438, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" }, { "start_pos": 515, "end_pos": 517, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MIH9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 589, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MIH9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MIH9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 18 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 110, "end_pos": 112 }, { "start_pos": 174, "end_pos": 176 }, { "start_pos": 231, "end_pos": 233 }, { "start_pos": 436, "end_pos": 438 }, { "start_pos": 465, "end_pos": 467 }, { "start_pos": 515, "end_pos": 517 }, { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJ59-1", "uniprot_ac": "F1MJ59", "uniprot_id": "F1MJ59_BOVIN", "mass": { "chemical_mass": 31159.0, "monoisotopic_mass": 31159.0 }, "refseq": {}, "gene_names": [ { "name": "NIT2", "type": "recommended", "evidence": [ { "id": "F1MJ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ59" } ] } ], "protein_names": [ { "name": "Omega-amidase NIT2", "type": "recommended", "evidence": [ { "id": "F1MJ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ59/entry#names_and_taxonomy" } ] }, { "name": "3.5.1.3", "type": "synonym", "evidence": [ { "id": "F1MJ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ59/entry#names_and_taxonomy" } ] }, { "name": "Nitrilase homolog 2", "type": "synonym", "evidence": [ { "id": "F1MJ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ59/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJ59", "url": "https://www.uniprot.org/uniprotkb/F1MJ59" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NIT2", "url": "https://www.uniprot.org/uniprotkb/F1MJ59", "locus": { "chromosome": "1", "start_pos": 44637448, "end_pos": 44617616, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004833", "url": "https://www.ensembl.org/id/ENSBTAG00000004833" } ] } } ], "crossref": [ { "id": "F1MJ59", "url": "https://alphafold.ebi.ac.uk/entry/F1MJ59", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004833", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004833", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07572", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07572", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036526", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036526", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MQSKPYA", "url": "https://omabrowser.org/oma/group/MQSKPYA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJX0", "url": "https://www.orthodb.org/?gene=A0A3Q1LJX0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N1V2", "url": "https://www.orthodb.org/?gene=A0A3Q1N1V2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MJ59", "url": "https://www.orthodb.org/?gene=F1MJ59", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23088", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23088", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23088:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23088:SF30", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00795", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00795", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "32963", "url": "https://www.rhea-db.org/rhea/32963", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "59412", "url": "https://www.rhea-db.org/rhea/59412", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LJX0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJX0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N1V2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1V2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N1V2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1V2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVT8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ59", "url": "https://www.uniprot.org/uniprotkb/F1MJ59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ59-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ59-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLPGRAMATFRLALIQLQVSSIKSENLTRACGLIREASKQGAQIVSLPECFNSPYGTKYFPDYAEKIPGDSTQKLSEVAKECSMYVIGGSIPEKDAGKLYNTCAVFGPDGTLLVKHRKLHLFDIDVPGKITFQESETLSPGDSFSSFDTPYCRVGLGICYDIRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRGRAVDNQVYVATASPARDEKASYVAWGHSTVVNPWGEVLAKAGTEETIVYADIDLKKLAEIRQQIPIFSQKRSDLYAVEAKKS", "length": 283, "header": "tr|F1MJ59-1|F1MJ59_BOVIN Isoform 1 of Omega-amidase NIT2 OS=Bos taurus OX=9913 GN=NIT2 PE=3 SV=2 CANONICAL=F1MJ59-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJX0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJX0/entry", "sequence": { "sequence": "LATLWTVASFRLALIQLQVSSIKSENLTRACGLIREASKQGAQIVSLPECFNSPYGTKYFPDYAEKIPGDSTQKLSEVAKECSMYVIGGSIPEKDAGKLYNTCAVFGPDGTLLVKHRKLHLFDIDVPGKITFQESETLSPGDSFSSFDTPYCRVGLGICYDIRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRGRAVDNQVYVATASPARDEKASYVAWGHSTVVNPWGEVLAKAGTEETIVYADIDLKKLAEIRQQIPIFSQKRSDLYAVEAKKS", "length": 282, "header": "tr|A0A3Q1LJX0-1|F1MJ59_BOVIN Computationally mapped isoform of Omega-amidase NIT2 OS=Bos taurus OX=9913 GN=NIT2 PE=3 SV=2 CANONICAL=F1MJ59-1" }, "locus": { "chromosome": "1", "start_pos": 44637159, "end_pos": 44622246, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075578.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075578.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056778.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056778.2" } ] } }, { "isoform_ac": "A0A3Q1N1V2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N1V2/entry", "sequence": { "sequence": "MALSQGCSTAALLTFAAVVLVTFRLALIQLQVSSIKSENLTRACGLIREASKQGAQIVSLPECFNSPYGTKYFPDYAEKIPGDSTQKLSEVAKECSMYVIGGSIPEKDAGKLYNTCAVFGPDGTLLVKHRKLHLFDIDVPGKITFQESETLSPGDSFSSFDTPYCRVGLGICYDIRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRGRAVDNQVYVATASPARDEKASYVAWGHSTVVNPWGEVLAKAGTEETIVYADIDLKKLAEIRQQIPIFSQKRSDLYAVEAKKS", "length": 295, "header": "tr|A0A3Q1N1V2-1|F1MJ59_BOVIN Computationally mapped isoform of Omega-amidase NIT2 OS=Bos taurus OX=9913 GN=NIT2 PE=3 SV=2 CANONICAL=F1MJ59-1" }, "locus": { "chromosome": "1", "start_pos": 44637159, "end_pos": 44622164, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087123.3", "url": "https://www.ensembl.org/id/ENSBTAT00000087123.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063122.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063122.2" } ] } }, { "isoform_ac": "A0AAA9RVT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVT8/entry", "sequence": { "sequence": "MVLPGRAMATFRLALIQLQVSSIKSENLTRACGLIREASKQGAQIVSLPECFNSPYGTKYFPDYAEKIPGDSTQKLSEVAKECSMYVIGGSIPEKDAGKLYNTCAVFGPDGTLLVKHRKLHLFDIDVPGKITFQESETLSPGDSFSSFDTRCQLLVYPGAFNLTTGPAHWELLQRGRAVDNQVYVATASPARDEKASYVAWGHSTVVNPWGEVLAKAGTEETIVYADIDLKKLAEIRQQIPIFSQKRSDLYAVEAKKS", "length": 258, "header": "tr|A0AAA9RVT8-1|F1MJ59_BOVIN Computationally mapped isoform of Omega-amidase NIT2 OS=Bos taurus OX=9913 GN=NIT2 PE=3 SV=1 CANONICAL=F1MJ59-1" }, "locus": { "chromosome": "1", "start_pos": 44637159, "end_pos": 44617644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132625.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132625.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075211.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075211.1" } ] } }, { "isoform_ac": "F1MJ59-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ59/entry", "sequence": { "sequence": "MVLPGRAMATFRLALIQLQVSSIKSENLTRACGLIREASKQGAQIVSLPECFNSPYGTKYFPDYAEKIPGDSTQKLSEVAKECSMYVIGGSIPEKDAGKLYNTCAVFGPDGTLLVKHRKLHLFDIDVPGKITFQESETLSPGDSFSSFDTPYCRVGLGICYDIRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRGRAVDNQVYVATASPARDEKASYVAWGHSTVVNPWGEVLAKAGTEETIVYADIDLKKLAEIRQQIPIFSQKRSDLYAVEAKKS", "length": 283, "header": "tr|F1MJ59-1|F1MJ59_BOVIN Isoform 1 of Omega-amidase NIT2 OS=Bos taurus OX=9913 GN=NIT2 PE=3 SV=2 CANONICAL=F1MJ59-1" }, "locus": { "chromosome": "1", "start_pos": 44637159, "end_pos": 44617644, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006347.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006347.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006347.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006347.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XIL3-1", "protein_name": "omega-amidase", "gene_name": "NIT2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQAARGAMANFRLALIQLHVSAVKSDNLQRACGLIREASAKGAKVVALPECFNSPYGTQYFKEYAEKIPGESTQKLSAVAKECSIYLIGGSIPEEDGGKLYNTCTVFGPDGAILAKHRKIHLFDINVPGKIQFKESETLSPGDSFSMFDTPYCKVGLGICYDIRFAELAQIYGQKGCQLLIYPGAFNMTTGPAHWELLQRGRAVDNQVYVATVSPARDEKASYVAWGHSTVVNPWGEVIAKAGAEETVIYTDIDLKKLAEIRQQIPILSQKRYDLYGIEMKK", "length": 282 }, "evidence": [ { "id": "F1MJ59", "url": "https://omabrowser.org/oma/group/F1MJ59/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SKY2-1", "protein_name": "Omega-amidase NIT2", "gene_name": "NIT2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVLLDKAMATFRLALIQLHVSSVKSDNLTRACGFIQEAAKQGAKIISLPECFNSPYGTKYFPEYAEKIPGDSTQKLSEVAKECGVYVIGGSIPEEDAGKLYNTCAVFGPDGTLLAKYRKLHLFDIDVPGKITFQESKTLSPGDSFSTFDTPYCRVGLGICYDIRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRGRAVDNQVYVATASPARDDKASYVAWGHSTIVSPWGEVLAKAGTEEKIVYADIDLKKLAEIRQQIPIFSQKRSDLYAVEVKKP", "length": 283 }, "evidence": [ { "id": "F1MJ59", "url": "https://omabrowser.org/oma/group/F1MJ59/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P49954-1", "protein_name": "Omega-amidase NIT3", "gene_name": "NIT3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSASKILSQKIKVALVQLSGSSPDKMANLQRAATFIERAMKEQPDTKLVVLPECFNSPYSTDQFRKYSEVINPKEPSTSVQFLSNLANKFKIILVGGTIPELDPKTDKIYNTSIIFNEDGKLIDKHRKVHLFDVDIPNGISFHESETLSPGEKSTTIDTKYGKFGVGICYDMRFPELAMLSARKGAFAMIYPSAFNTVTGPLHWHLLARSRAVDNQVYVMLCSPARNLQSSYHAYGHSIVVDPRGKIVAEAGEGEEIIYAELDPEVIESFRQAVPLTKQRRFDVYSDVNAH", "length": 291 }, "evidence": [ { "id": "F1MJ59", "url": "https://omabrowser.org/oma/group/F1MJ59/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q497B0-1", "protein_name": "Omega-amidase NIT2", "gene_name": "Nit2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTFRLALIQLQVSSIKSDNITRACSLVREAAKQGANIVSLPECFNSPYGTNYFPEYAEKIPGESTKKLSEVAKENSIYLIGGSIPEEDDGKLYNTCAVFGPDGNLLVKHRKIHLFDIDVPGKITFQESKTLSPGDSFSTFDTPYCRVGLGICYDMRFAELAQIYARRGCQLLVYPGAFNMTTGPAHWELLQRARAVDNQVYVATASPARDEKASYVAWGHSTVVDPWGQVLTKAGTEETILYSDIDLKKLSEIRQQIPILKQKRADLYSVESKKP", "length": 276 }, "evidence": [ { "id": "F1MJ59", "url": "https://omabrowser.org/oma/group/F1MJ59/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q4VBV9-1", "protein_name": "Omega-amidase NIT2", "gene_name": "nit2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSKFRLAVVQLHVSKIKADNLGRAQTLVKEAAGQGAKVVVLPECFNSPYGTGFFKEYAEKIPGESTQVLSETAKKCGIYLVGGSIPEEDGGKLYNTCSVFGPDGTLLVTHRKIHLFDIDVPGKIRFQESETLSPGKSLSMFETPYCKVGVGICYDIRFAELAQIYAKKGCQLLVYPGAFNMTTGPAHWELLQRGRAVDNQVYVATASPARDETASYVAWGHSSVINPWGEVISKAGSEESVVYADIDLQYLADVRQQIPITKQRRNDLYSVNSVQEG", "length": 277 }, "evidence": [ { "id": "F1MJ59", "url": "https://omabrowser.org/oma/group/F1MJ59/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q54JM9-1", "protein_name": "Nitrilase homolog 2", "gene_name": "nit2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MYRGLINSFKNTSKFSTSLFNNNNNCSTTTKSFTHISQQLRKVHLMADKEKVFKFAGIQLLCGDNKEENVQNAIKHIDEAAKNGAKLISLPECFNSPYSTSTFEKYSETEDGETVKKLSEAAKRNQIFLVGGSIPEIDKATGKIYNTCFIFNDKGEVVKKHRKIHLFDIDVPNKIRFKESETLTPGDSFSVVDIGYCKIGVAICYDIRFPELAMLYSKMGAKFLIYPGAFNMVTGPAHWELLQRGRAVDNQVFVAAISPARNPSSTYQAWGHSTIVNSWGTILATTDEHQSIIYSDIDLNTLNETRSSIPIYSQKRDDLYKLDSIKKQ", "length": 328 }, "evidence": [ { "id": "F1MJ59", "url": "https://omabrowser.org/oma/group/F1MJ59/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8RUF8-1", "protein_name": "Omega-amidase, chloroplastic", "gene_name": "NLP3", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKSAISSSLFFNSKNLLNPNPLSRFISLKSNFLPKLSPRSITSHTLKLPSSSTSALRSISSSMASSFNPEQARVPSALPLPAPPLTKFNIGLCQLSVTSDKKRNISHAKKAIEEAASKGAKLVLLPEIWNSPYSNDSFPVYAEEIDAGGDASPSTAMLSEVSKRLKITIIGGSIPERVGDRLYNTCCVFGSDGELKAKHRKIHLFDIDIPGKITFMESKTLTAGETPTIVDTDVGRIGIGICYDIRFQELAMIYAARGAHLLCYPGAFNMTTGPLHWELLQRARATDNQLYVATCSPARDSGAGYTAWGHSTLVGPFGEVLATTEHEEAIIIAEIDYSILEQRRTSLPLNRQRRGDLYQLVDVQRLDSK", "length": 369 }, "evidence": [ { "id": "F1MJ59", "url": "https://omabrowser.org/oma/group/F1MJ59/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9JHW2-1", "protein_name": "Omega-amidase NIT2", "gene_name": "Nit2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTFRLALIQLQVSSIKSDNLTRACSLVREAAKQGANIVSLPECFNSPYGTTYFPDYAEKIPGESTQKLSEVAKESSIYLIGGSIPEEDAGKLYNTCSVFGPDGSLLVKHRKIHLFDIDVPGKITFQESKTLSPGDSFSTFDTPYCKVGLGICYDMRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRARAVDNQVYVATASPARDDKASYVAWGHSTVVDPWGQVLTKAGTEETILYSDIDLKKLAEIRQQIPILKQKRADLYTVESKKP", "length": 276 }, "evidence": [ { "id": "F1MJ59", "url": "https://omabrowser.org/oma/group/F1MJ59/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NQR4-1", "protein_name": "Omega-amidase NIT2", "gene_name": "NIT2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSFRLALIQLQISSIKSDNVTRACSFIREAATQGAKIVSLPECFNSPYGAKYFPEYAEKIPGESTQKLSEVAKECSIYLIGGSIPEEDAGKLYNTCAVFGPDGTLLAKYRKIHLFDIDVPGKITFQESKTLSPGDSFSTFDTPYCRVGLGICYDMRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRSRAVDNQVYVATASPARDDKASYVAWGHSTVVNPWGEVLAKAGTEEAIVYSDIDLKKLAEIRQQIPVFRQKRSDLYAVEMKKP", "length": 276 }, "evidence": [ { "id": "F1MJ59", "url": "https://omabrowser.org/oma/group/F1MJ59/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VHE4-1", "protein_name": "omega-amidase", "gene_name": "Dmel\\CG8132", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSKTSNIMRLALLQLKGSKDKVANVQNAVTKIEAAVKEHKPRLITLPECFNAPYGTKYFREYSETIPDGYTSQQLSNLARKHQVYIVGGTIPELGENDAIYNTCTVWSPTGDLVAKHRKMHLFDIDVKGGIRFKESETLSAGNDFTIINVDGHKIGIGICYDIRFEEMARLYRNAGCEMIIYPAAFNMTTGPLHWELLQRSRANDNQLFVVTTSPARDTSAEYVAYGHSMVVNPWAKVQQSASEGEEIVVADIDFSEVEQVRQQIPVFGQRRLDLYATERKAK", "length": 283 }, "evidence": [ { "id": "F1MJ59", "url": "https://omabrowser.org/oma/group/F1MJ59/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "asparagine metabolic process", "id": "GO:0006528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006528", "evidence": [ { "database": "UniProtKB", "id": "F1MJ59", "url": "https://www.uniprot.org/uniprotkb/F1MJ59" } ], "pmid": "" }, { "name": "oxaloacetate metabolic process", "id": "GO:0006107", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006107", "evidence": [ { "database": "UniProtKB", "id": "F1MJ59", "url": "https://www.uniprot.org/uniprotkb/F1MJ59" } ], "pmid": "" }, { "name": "glutamine metabolic process", "id": "GO:0006541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006541", "evidence": [ { "database": "UniProtKB", "id": "F1MJ59", "url": "https://www.uniprot.org/uniprotkb/F1MJ59" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "omega-amidase activity", "id": "GO:0050152", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050152", "evidence": [ { "database": "UniProtKB", "id": "F1MJ59", "url": "https://www.uniprot.org/uniprotkb/F1MJ59" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MJ59", "url": "https://www.uniprot.org/uniprotkb/F1MJ59" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "32963", "name": "", "equation": "2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJ59-1", "Q2T9R6-1" ], "evidence": [ { "id": "32963", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32963" } ] }, { "id": "59412", "name": "", "equation": "2-oxosuccinamate + H2O = oxaloacetate + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJ59-1", "Q2T9R6-1" ], "evidence": [ { "id": "59412", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/59412" } ] }, { "id": "R-BTA-6798745", "name": "Exocytosis of tertiary granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, tertiary granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P24627-1", "Q3SZH7-1", "A0AAA9S4U4-1", "A0AAA9S9V5-1", "O46414-1", "P25326-1", "F1MMR6-1", "P80189-1", "P52176-1", "Q17QB3-1", "A7YWG4-1", "F1MJ59-1", "F6RY99-1", "A0A140T8A5-1" ], "evidence": [ { "id": "R-BTA-6798745", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798745" } ] }, { "id": "R-BTA-6798749", "name": "Exocytosis of specific granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, specific granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P24627-1", "A0AAA9S9V5-1", "F1N1G1-1", "Q0II59-1", "F1MMR6-1", "P05689-1", "P80189-1", "A7YWG4-1", "E1BPI3-1", "F1MJ59-1", "F6RY99-1", "A6BMK7-1", "Q2KJ64-1" ], "evidence": [ { "id": "R-BTA-6798749", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798749" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T8A5", "gene_name": "IDH1", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "A0A140T8A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T8A5" } ] } ] }, { "uniprot_ac": "A0AAA9S4U4", "gene_name": "ALDOC", "activity": [ { "ec_number": "4.1.2.13", "activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.", "evidence": [ { "id": "A0AAA9S4U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4U4" } ] }, { "ec_number": "4.1.2.13", "activity": "", "evidence": [ { "id": "A0AAA9S4U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4U4" } ] } ] }, { "uniprot_ac": "A0AAA9S9V5", "gene_name": "CANT1", "activity": [ { "ec_number": "3.6.1.6", "activity": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ] }, { "ec_number": "3.6.1.6", "activity": "", "evidence": [ { "id": "A0AAA9S9V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9V5" } ] } ] }, { "uniprot_ac": "A6BMK7", "gene_name": "NEU1", "activity": [ { "ec_number": "3.2.1.18", "activity": "Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.", "evidence": [ { "id": "A6BMK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6BMK7" } ] }, { "ec_number": "3.2.1.18", "activity": "", "evidence": [ { "id": "A6BMK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6BMK7" } ] } ] }, { "uniprot_ac": "A7YWG4", "gene_name": "GGH", "activity": [ { "ec_number": "3.4.19.9", "activity": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate.", "evidence": [ { "id": "A7YWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWG4" } ] }, { "ec_number": "3.4.19.9", "activity": "", "evidence": [ { "id": "A7YWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWG4" } ] } ] }, { "uniprot_ac": "E1BPI3", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] } ] }, { "uniprot_ac": "F1MJ59", "gene_name": "NIT2", "activity": [ { "ec_number": "3.5.1.3", "activity": "2-oxosuccinamate + H2O = oxaloacetate + NH4(+).", "evidence": [ { "id": "F1MJ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ59" } ] }, { "ec_number": "3.5.1.3", "activity": "", "evidence": [ { "id": "F1MJ59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ59" } ] } ] }, { "uniprot_ac": "F1MMR6", "gene_name": "CTSD", "activity": [ { "ec_number": "3.4.23.5", "activity": "Specificity similar to, but narrower than, that of pepsin A. 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"https://www.uniprot.org/uniprotkb/F1MHG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHG6-1", "url": "https://www.uniprot.org/uniprotkb/F1MHG6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVHHSGSIQSFKQQKGMNISKSEIAKETSLKPSRRSLPCLAQSYAYSKSLSQSTSLFQSIESESQDPTSVTSISADKAEQVNTEEERKDSVLKCSFTDLSDFCLDLGKDKDYTDESEHANYDRSRLIKDFVPKNNSEPKPRLPKNDMNYIASSGLLFKDGKKRIDYILVYRKSNIQYDKRNTFEKNLRAEGLMLEKEPAVANSDIMFIKIHIPWDTLCKYAERLNIRMPFRKKSYYTDRRSKSMGRVQKYFRRIKKWMSQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLQHTKYENGISKVGICKLINNGSYIAAFPPHEGAYKSNQPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGILTMNASQVSQEICKATEVFMCPLCDKNCSLQRLNESCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSTLTYTWDLIEWEEEEETLRPQFEAKYYKMERVNPISGKPEPHQPSSDKVTRLLVSISGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFIKQHWQFATSAAAVCINFVIIMALNVAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFNRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWYGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCATHFEYSESCLTGYVNNSLSFFDLSELGIGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKNLYDRIRREKYLVQEMMYEAELEHLQQQRRKSGHPVHHEWP", "length": 981, "header": "tr|F1MHG6-1|F1MHG6_BOVIN Isoform 1 of Anoctamin OS=Bos taurus OX=9913 GN=ANO3 PE=3 SV=3 CANONICAL=F1MHG6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MUE0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUE0/entry", "sequence": { "sequence": "MSTVKFELDNLSPEGFRHEHASSSDFALTCLTELSGDSSQWELQHSNSVPVVTHRSLSSALKWSYLIGMNISKSEIAKETSLKPSRRSLPCLAQSYAYSKSLSQSTSLFQSIESESQDPTSVTSISADKAEQVNTEEERKDSVLKCSFTDLSDFCLDLGKDKDYTDESEHANYDRSRLIKDFVPKNNSEPKPRLPKNDMNYIASSGLLFKDGKKRIDYILVYRKSNIQYDKRNTFEKNLRAEGLMLEKEPAVANSDIMFIKIHIPWDTLCKYAERLNIRMPFRKKSYYTDRRSKSMGRVQKYFRRIKKWMSQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLQHTKYENGISKVGICKLINNGSYIAAFPPHEGAYKSNQPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGILTMNASQVSQEICKATEVFMCPLCDKNCSLQRLNESCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSTLTYTWDLIEWEEEEETLRPQFEAKYYKMERVNPISGKPEPHQPSSDKVTRLLVSISGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFIKQHWQFATSAAAVCINFVIIMALNVAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFNRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWYGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCATHFEYSESCLTGYVNNSLSFFDLSELGIGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKNLYDRIRREKYLVQEMMYEAELEHLQQQRRKSGHPVHHEWP", "length": 1033, "header": "tr|A0A3Q1MUE0-1|F1MHG6_BOVIN Computationally mapped isoform of Anoctamin OS=Bos taurus OX=9913 GN=ANO3 PE=3 SV=1 CANONICAL=F1MHG6-1" }, "locus": { "chromosome": "15", "start_pos": 57350899, "end_pos": 56897156, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078140.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078140.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074171.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074171.1" } ] } }, { "isoform_ac": "A0A3Q1N7W6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7W6/entry", "sequence": { "sequence": "MSTVKFELDNLSPEGFRHEHASSSDFALTCLTELSGDSSQWELQHSNSVPVGMNISKSEIAKETSLKPSRRSLPCLAQSYAYSKSLSQSTSLFQSIESESQDPTSVTSISADKAEQVNTEEERKDSVLKCSFTDLSDFCLDLGKDKDYTDESEHANYDRSRLIKDFVPKNNSEPKPRLPKNDMNYIASSGLLFKDGKKRIDYILVYRKSNIQYDKRNTFEKNLRAEGLMLEKEPAVANSDIMFIKIHIPWDTLCKYAERLNIRMPFRKKSYYTDRRSKSMGRVQKYFRRIKKWMSQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLQHTKYENGISKVGICKLINNGSYIAAFPPHEGAYKSNQPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGILTMNASQVSQEICKATEVFMCPLCDKNCSLQRLNESCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSTLTYTWDLIEWEEEEETLRPQFEAKYYKMERVNPISGKPEPHQPSSDKVTRLLVSISGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFIKQHWQFATSAAAVCINFVIIMALNVAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFNRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWYGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCATHFEYSESCLTGYVNNSLSFFDLSELGIGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKNLYDRIRREKYLVQEMMYEAELEHLQQQRRKSGHPVHHEWP", "length": 1017, "header": "tr|A0A3Q1N7W6-1|F1MHG6_BOVIN Computationally mapped isoform of Anoctamin OS=Bos taurus OX=9913 GN=ANO3 PE=3 SV=2 CANONICAL=F1MHG6-1" }, "locus": { "chromosome": "15", "start_pos": 57350899, "end_pos": 56897156, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072444.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072444.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066961.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066961.2" } ] } }, { "isoform_ac": "F1MHG6-1", "url": "https://www.uniprot.org/uniprotkb/F1MHG6/entry", "sequence": { "sequence": "MVHHSGSIQSFKQQKGMNISKSEIAKETSLKPSRRSLPCLAQSYAYSKSLSQSTSLFQSIESESQDPTSVTSISADKAEQVNTEEERKDSVLKCSFTDLSDFCLDLGKDKDYTDESEHANYDRSRLIKDFVPKNNSEPKPRLPKNDMNYIASSGLLFKDGKKRIDYILVYRKSNIQYDKRNTFEKNLRAEGLMLEKEPAVANSDIMFIKIHIPWDTLCKYAERLNIRMPFRKKSYYTDRRSKSMGRVQKYFRRIKKWMSQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLQHTKYENGISKVGICKLINNGSYIAAFPPHEGAYKSNQPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGILTMNASQVSQEICKATEVFMCPLCDKNCSLQRLNESCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSTLTYTWDLIEWEEEEETLRPQFEAKYYKMERVNPISGKPEPHQPSSDKVTRLLVSISGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFIKQHWQFATSAAAVCINFVIIMALNVAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFNRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWYGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCATHFEYSESCLTGYVNNSLSFFDLSELGIGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKNLYDRIRREKYLVQEMMYEAELEHLQQQRRKSGHPVHHEWP", "length": 981, "header": "tr|F1MHG6-1|F1MHG6_BOVIN Isoform 1 of Anoctamin OS=Bos taurus OX=9913 GN=ANO3 PE=3 SV=3 CANONICAL=F1MHG6-1" }, "locus": { "chromosome": "15", "start_pos": 57350899, "end_pos": 57063261, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029137.8", "url": "https://www.ensembl.org/id/ENSBTAT00000029137.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029137.6", "url": "https://www.ensembl.org/id/ENSBTAP00000029137.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100139986", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100139986", "resource": "KEGG Pathway" }, { "id": "R-BTA-2672351", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "resource": "Reactome", "description": "Stimuli-sensing channels" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZBL9-1", "protein_name": "Anoctamin", "gene_name": "ANO3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAVIIELDKLSSDESESRKDSKSGFKEGKLSEFCAEYCGFQLHCSHSAPAGMNTSKSEMVKEHSLKPSRRSMPCLVQSQTHPQSLSKHSSFLQPNRVQPQPQPLSAGASTATVDVVSERAKVMETLENNLLKLSSTEYSDPFLDIGKDKDPYTDDSEHGNYDVRTDQSLLIQNKLTRQKTEPRTKSSLKTDAMASSGLFFKDGKKRIDYILVYKKSSLQIEKRSTFEKNLRAEGLMLEREPAVTNSDIMFVKIHCPWETLCKYAERMNIRMPFRKKCYYTDWRSKTMGSLQRNMRELKSWLPRNPMKLDKEALPDLEETDCYTAPFSRARIHHFTINNKDSFFSNSTRSRIVHHMLQRTKYEDGKSKMGINRLLNNGTYEAAFPPHEGSHKSRHPIKTHGAQNHRHLLYERWARWGMWYKYQPLDLIRRYFGEKIGLYFAWLGWYTGMLIPAALVGLFVFLYGLFTMDSSQVSKEICEANETIMCPMCERNCTLQKLNESCIYAKVTHLFDNGGTVFFAIFMAIWATVFLEFWKRRRAVLTYDWDLIDWEDEEEELRPQFEAKYSQVERVNPITGKPEPFQPFPDKLSRLMVSVSGIFFMISLVLTAVFAVVVYRLVAMEQFASFKWYFIKKYWQFATSGTGVCINFMIIMSLNVVYEKVAYLLTDLEHPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFAGRPGKYNKLFNRWRLEECHPSGCLIDLCLQMGVIMVLKQMWNNFMELGYPLLQNWWSRRKMKRRGQSMEHKISLPQWEKDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPMPARATDIGIWYGILEGIGVLAVITNAFVIAITSDYIPRFVYAYKYGPCTDQGYRQEKCLKGYVNSSLSVFDLSELGMGYSGYCRYRDYRAPPWSSTPYEFTLQFWHVLAARLAFIIVFEHLVFGIKSFIAYLIPDMPKDLCDRMRREKYLVQEMMYEAELEHLQRERKKNGKQYHHEWP", "length": 1029 }, "evidence": [ { "id": "F1MHG6", "url": "https://omabrowser.org/oma/group/F1MHG6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2AHL1-1", "protein_name": "Anoctamin-3", "gene_name": "Ano3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVHHSGSIQSFKQQKGMNISKSEITTEASLKPSRRSLPCLAQSYAHSKSLSQSASLFQSTESESQAPTSVTFLSADKPEHVTSEESRKDSTLKCSFADLSDFCLALGKDKDYLDESEHANYDRSRLLNDFVTKDKPASKTKLSKNDMSYIASSGLLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIANPDIMFIKIHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSKSRVQNYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLITNGSYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRMYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEVINPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFVKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVKQNENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQEMMYEAELEHLQQQRRKSGQPIHHEWP", "length": 981 }, "evidence": [ { "id": "F1MHG6", "url": "https://omabrowser.org/oma/group/F1MHG6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1M0A0-1", "protein_name": "Anoctamin", "gene_name": "Ano3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVHHSGSIQSFKQQKGMNISKSEITTEASLKPSRRSLPCLAQSYAHSKSLSQSASLFQSTESESQAPTSVTFLSADKPEHVTSEESRKDSTLKCSFADLSEFCLALGKDKDYMDESEHANYDRSRLLNDFVTKDKPESKTKLSKNDMNYIASSGLLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAVANPDIMFIKVHIPWDTLCKYAERLNIRVPFRKKCYYTDQKNKSMSRVQKYFKRIKKWMSQNPMVLDKSAFPELEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSLPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAVVGLCVFFYGLVTMNESQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYRMEIINPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFAVVVYRLVVMEQFASFKWNFIKQHWQFATSGAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFERWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIQDASIPQWENDWNLQPMNIHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVKQNENCLKGYVNNSLSFFDLSELGIGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDIPKGLRERIRREKYLVQEMMYEAELEHLQQQRRKSGQPIHHEWP", "length": 981 }, "evidence": [ { "id": "F1MHG6", "url": "https://omabrowser.org/oma/group/F1MHG6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BYT9-1", "protein_name": "Anoctamin-3", "gene_name": "ANO3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVHHSGSIQSFKQQKGMNISKSEITKETSLKPSRRSLPCLAQSYAYSKSLSQSTSLFQSTESESQAPTSITLISTDKAEQVNTEENKNDSVLRCSFADLSDFCLALGKDKDYTDESEHATYDRSRLINDFVIKDKSEFKTKLSKNDMNYIASSGPLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIASPDIMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYTDGRSKSMGRMQTYFRRIKNWMAQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQEMMYEAELEHLQQQRRKSGQPVHHEWP", "length": 981 }, "evidence": [ { "id": "F1MHG6", "url": "https://omabrowser.org/oma/group/F1MHG6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MHG6", "url": "https://www.uniprot.org/uniprotkb/F1MHG6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "F1MHG6", "url": "https://www.uniprot.org/uniprotkb/F1MHG6" } ], "pmid": "" }, { "name": "phospholipid scramblase activity", "id": "GO:0017128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017128", "evidence": [ { "database": "UniProtKB", "id": "F1MHG6", "url": "https://www.uniprot.org/uniprotkb/F1MHG6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phospholipid translocation", "id": "GO:0045332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045332", "evidence": [ { "database": "UniProtKB", "id": "F1MHG6", "url": "https://www.uniprot.org/uniprotkb/F1MHG6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" }, { "start_pos": 302, "end_pos": 304, "annotation": "n_glycosylation_sequon" }, { "start_pos": 333, "end_pos": 335, "annotation": "n_glycosylation_sequon" }, { "start_pos": 425, "end_pos": 427, "annotation": "n_glycosylation_sequon" }, { "start_pos": 448, "end_pos": 450, "annotation": "n_glycosylation_sequon" }, { "start_pos": 455, "end_pos": 457, "annotation": "n_glycosylation_sequon" }, { "start_pos": 650, "end_pos": 652, "annotation": "n_glycosylation_sequon" }, { "start_pos": 866, "end_pos": 868, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MHG6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 981, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MHG6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MHG6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MHG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHG6" }, { "id": "PF16178", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16178" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Anoctamin dimerisation", "eco_id": "ECO_0000259", "start_pos": 157, "end_pos": 381, "start_aa": "Phe", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MHG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHG6" }, { "id": "PF04547", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04547" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Anoctamin transmembrane", "eco_id": "ECO_0000259", "start_pos": 384, "end_pos": 949, "start_aa": "Ile", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 134, "end_pos": 136 }, { "start_pos": 18, "end_pos": 20 }, { "start_pos": 302, "end_pos": 304 }, { "start_pos": 333, "end_pos": 335 }, { 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"count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGT0-1", "uniprot_ac": "F1MGT0", "uniprot_id": "F1MGT0_BOVIN", "mass": { "chemical_mass": 23954.0, "monoisotopic_mass": 23954.0 }, "refseq": {}, "gene_names": [ { "name": "MND1", "type": "recommended", "evidence": [ { "id": "F1MGT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGT0" } ] } ], "protein_names": [ { "name": "Meiotic nuclear division protein 1 homolog", "type": "recommended", "evidence": [ { "id": "F1MGT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGT0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NEL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEL5#function" }, { "database": "UniProtKB", "id": "PIRNR026991", "url": "https://www.uniprot.org/uniprotkb/PIRNR026991#function" }, { "database": "UniProtKB", "id": "A0AAA9SF30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF30#function" }, { "database": "UniProtKB", "id": "A0A3Q1MBH1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBH1#function" }, { "database": "UniProtKB", "id": "A0A3Q1LTI5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTI5#function" }, { "database": "UniProtKB", "id": "F1MGT0", "url": "https://www.uniprot.org/uniprotkb/F1MGT0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MGT0", "url": "https://www.uniprot.org/uniprotkb/F1MGT0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MND1", "url": "https://www.uniprot.org/uniprotkb/F1MGT0", "locus": { "chromosome": "17", "start_pos": 4187768, "end_pos": 4298314, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000281", "url": "https://www.ensembl.org/id/ENSBTAG00000000281" } ] } } ], "crossref": [ { "id": "F1MGT0", "url": "https://alphafold.ebi.ac.uk/entry/F1MGT0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000281", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000281", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618239", "url": "https://www.ncbi.nlm.nih.gov/gene/618239", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005647", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005647", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040453", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040453", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040661", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040661", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VCYWAFP", "url": "https://omabrowser.org/oma/group/VCYWAFP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LTI5", "url": "https://www.orthodb.org/?gene=A0A3Q1LTI5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBH1", "url": "https://www.orthodb.org/?gene=A0A3Q1MBH1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NEL5", "url": "https://www.orthodb.org/?gene=A0A3Q1NEL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MGT0", "url": "https://www.orthodb.org/?gene=F1MGT0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31398", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31398", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31398:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31398:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03962", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03962", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18517", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18517", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LTI5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTI5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTI5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBH1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBH1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJT7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJT7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NEL5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NEL5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF30", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF30", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF30-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD65", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TD65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGT0", "url": "https://www.uniprot.org/uniprotkb/F1MGT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGT0-1", "url": "https://www.uniprot.org/uniprotkb/F1MGT0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKKKGLSAEEKRTRMMEIFYETKDVFQLKDMEKIAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEVLDSQLSEGNQKYANLQKSIEKAKVGRHETEERTMLAKELSSLRDQREQLKAEVEKYRECDPQVVEEIRQANQVAKEAANRWTDNIFAIKSWAKRKFGFEENKIDKNFGIPEDFDYID", "length": 205, "header": "tr|F1MGT0-1|F1MGT0_BOVIN Isoform 1 of Meiotic nuclear division protein 1 homolog OS=Bos taurus OX=9913 GN=MND1 PE=3 SV=1 CANONICAL=F1MGT0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTI5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTI5/entry", "sequence": { "sequence": "MSKKKGLSAEEKRTRMMEIFYETKDVFQLKDMEKIAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEVLDSQLSEGNQKYANLQKSIEKAKVGRHETEERTMLAKELSSLRDQREQLKAEVEKYRECDPQVVEEIHNIFAIKSWAKRKFGFEENKIDKNFGIPEDFDYID", "length": 190, "header": "tr|A0A3Q1LTI5-1|F1MGT0_BOVIN Computationally mapped isoform of Meiotic nuclear division protein 1 homolog OS=Bos taurus OX=9913 GN=MND1 PE=3 SV=1 CANONICAL=F1MGT0-1" }, "locus": { "chromosome": "17", "start_pos": 4297764, "end_pos": 4218455, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070619.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070619.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063781.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063781.1" } ] } }, { "isoform_ac": "A0A3Q1MBH1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBH1/entry", "sequence": { "sequence": "MSKKKGLSAEEKRTRMMEIFYETDLQSLAWPSLLAVFIIYKYDKDVFQLKDMEKIAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEVLDSQLSEGNQKYANLQKSIEKAKVGRHETEERTMLAKELSSLRDQREQLKAEVEKYRECDPQVVEEIRQANQVAKEAANRWTDNIFAIKSWAKRKFGFEENKIDKNFGIPEDFDYID", "length": 225, "header": "tr|A0A3Q1MBH1-1|F1MGT0_BOVIN Computationally mapped isoform of Meiotic nuclear division protein 1 homolog OS=Bos taurus OX=9913 GN=MND1 PE=3 SV=2 CANONICAL=F1MGT0-1" }, "locus": { "chromosome": "17", "start_pos": 4297764, "end_pos": 4218455, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068183.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068183.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068057.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068057.2" } ] } }, { "isoform_ac": "A0A3Q1MJT7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJT7/entry", "sequence": { "sequence": "RQRRGLKTSSEKKVGLHSAPRTENGSSCESLSASLWSADGRDQAGPAPRIGPAHPDRPLAAAAARGRCAPQERGLVFLPLLAAPPAGRCRRQNQTQPSRPRPSPRAGPAAGRRAAGAMLSEGNQKYANLQKSIEKAKVGRHETEERTMLAKELSSLRDQREQLKAEVEKYRECDPQVVEEIRQANQVAKEAANRWTDNIFAIKSWAKRKFGFEENKIDKNFGIPEDFDYID", "length": 231, "header": "tr|A0A3Q1MJT7-1|F1MGT0_BOVIN Computationally mapped isoform of Meiotic nuclear division protein 1 homolog OS=Bos taurus OX=9913 GN=MND1 PE=3 SV=1 CANONICAL=F1MGT0-1" }, "locus": { "chromosome": "17", "start_pos": 4298115, "end_pos": 4218455, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087414.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087414.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071649.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071649.2" } ] } }, { "isoform_ac": "A0A3Q1NEL5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEL5/entry", "sequence": { "sequence": "IAEEKRTRMMEIFYETKDVFQLKDMEKIAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEVLDSQLSEGNQKYANLQKSIEKAKVGRHETEERTMLAKELSSLRDQREQLKAEVEKYRECDPQVVEEIRQANQVAKEAANRWTDNIFAIKSWAKRKFGFEENKIDKNFGIPEDFDYID", "length": 198, "header": "tr|A0A3Q1NEL5-1|F1MGT0_BOVIN Computationally mapped isoform of Meiotic nuclear division protein 1 homolog OS=Bos taurus OX=9913 GN=MND1 PE=3 SV=1 CANONICAL=F1MGT0-1" }, "locus": { "chromosome": "17", "start_pos": 4292695, "end_pos": 4218455, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072261.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072261.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070076.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070076.1" } ] } }, { "isoform_ac": "A0AAA9SF30-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF30/entry", "sequence": { "sequence": "MSKKKGLSAEEKRTRMMEIFYETKDVFQLKDMEKIAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEVLDSQLSEGNQKYANLQKSIEKAKVGRHETEERTMLAKELSSLRDQREQLKAEVEKYRECDPQVVEEIRQANQVAKEAANRWTGSNEEDLDQRRVGWASLQE", "length": 189, "header": "tr|A0AAA9SF30-1|F1MGT0_BOVIN Computationally mapped isoform of Meiotic nuclear division protein 1 homolog OS=Bos taurus OX=9913 GN=MND1 PE=3 SV=1 CANONICAL=F1MGT0-1" }, "locus": { "chromosome": "17", "start_pos": 4297764, "end_pos": 4187948, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133331.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133331.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084768.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084768.1" } ] } }, { "isoform_ac": "A0AAA9TD65-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD65/entry", "sequence": { "sequence": "MSKKKGLSAEEKRTRMMEIFYETKDVFQLKDMEKIAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEVLDSQLSEGNQKYANLQKSIEKAKVGRHETVKQIKW", "length": 123, "header": "tr|A0AAA9TD65-1|F1MGT0_BOVIN Computationally mapped isoform of Meiotic nuclear division protein 1 homolog OS=Bos taurus OX=9913 GN=MND1 PE=3 SV=1 CANONICAL=F1MGT0-1" }, "locus": { "chromosome": "17", "start_pos": 4297764, "end_pos": 4224432, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127608.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127608.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094090.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094090.1" } ] } }, { "isoform_ac": "F1MGT0-1", "url": "https://www.uniprot.org/uniprotkb/F1MGT0/entry", "sequence": { "sequence": "MSKKKGLSAEEKRTRMMEIFYETKDVFQLKDMEKIAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEVLDSQLSEGNQKYANLQKSIEKAKVGRHETEERTMLAKELSSLRDQREQLKAEVEKYRECDPQVVEEIRQANQVAKEAANRWTDNIFAIKSWAKRKFGFEENKIDKNFGIPEDFDYID", "length": 205, "header": "tr|F1MGT0-1|F1MGT0_BOVIN Isoform 1 of Meiotic nuclear division protein 1 homolog OS=Bos taurus OX=9913 GN=MND1 PE=3 SV=1 CANONICAL=F1MGT0-1" }, "locus": { "chromosome": "17", "start_pos": 4297764, "end_pos": 4218455, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000351.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000351.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000351.3", "url": "https://www.ensembl.org/id/ENSBTAP00000000351.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N339-1", "protein_name": "Meiotic nuclear division protein 1 homolog", "gene_name": "Mnd1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSKKKGLSAEEKRTRMMEIFFETKDVFQLKDLEKLAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEALTSQLSEGNQRHANLQKSIEKARIGRQETEERAMLTKELSSFRDQREQLKAEVEKYRECDPQVVEEIRKANIVAKEAANRWTDNIFAIKSWAKRKFGFEESKIDKNFGIPEDFDYID", "length": 205 }, "evidence": [ { "id": "F1MGT0", "url": "https://omabrowser.org/oma/group/F1MGT0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1LWN6-1", "protein_name": "Meiotic nuclear division protein 1 homolog", "gene_name": "Mnd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSKKRGLSGEEKRTRMMEIFFETKDVFQLKDLEKLAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEALNSQLSEGSQKHADLQKSIEKARVGRQETEERAMLAKELSSFQDQRKKLKAEVEKYRECDPQVVEEIRQANKVAKEAANRWTDNIFAIKSWAKRKYGFEETKIDKNFGIPEDFDYVD", "length": 205 }, "evidence": [ { "id": "F1MGT0", "url": "https://omabrowser.org/oma/group/F1MGT0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P53102-1", "protein_name": "Meiotic nuclear division protein 1", "gene_name": "MND1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGPKRQTVSLQEKKNRILNFFQETYTFYNIKELEKSIPKKCGISPMIVKDLVQQMIDEDGVISVEKCGNINIYWCFKNQTLQKLYDSSELIKKKIQEVKCDIATYKQELDKTLATGRRKKFTVGQKSYNREALLEKRKKIQDEIKKKSNSLQKIESIRWDAAKIQENKQQIRLKKVHLEKTTDNIEILIDYLYKKFFLKPEQIRKEFGIPEEFKEFTEV", "length": 219 }, "evidence": [ { "id": "F1MGT0", "url": "https://omabrowser.org/oma/group/F1MGT0/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54E86-1", "protein_name": "Meiotic nuclear division protein 1 homolog", "gene_name": "mnd1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MATRRKGMSPEEKKEKLKEFFHSNSTIYSSKDVESEASKYTGMTQVQCKETLQMLIDDGVVNTDKMGSSNFYWSFPSFEFDSKKDKIIEQTKLLSETKERIQSETKKIEQLKSERVESETRTKNLEKLQTLKDDNKSFKEELLLYADSSLIDDKKRDIKIAIAAVNRYTDNISSLRQFCDSKYNIRPSDFDTSFGIKPDMDYLEEYNFNDTPQPVNKKKRK", "length": 221 }, "evidence": [ { "id": "F1MGT0", "url": "https://omabrowser.org/oma/group/F1MGT0/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6DC61-1", "protein_name": "Meiotic nuclear division protein 1 homolog", "gene_name": "mnd1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSKKKGLSLEEKRSRMMEIFFETKDVFQLKDIEKIAPKSKGITPMSVKEVLQSLVDDNMVDTERVGTSNYYWAFPSKALHARKRRLEELEKQLEDGSQRKKALQQAVDKAKVGREVNEEREDLLKELTALKGQRDQMKVEIEKYQECDPAVVEEIRNANIAAKEAVARWTGGTFGNYLISYLLTCSLTRQEPWAHHLSPSSGFSPGTACQTCYYYQQAIS", "length": 220 }, "evidence": [ { "id": "F1MGT0", "url": "https://omabrowser.org/oma/group/F1MGT0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8GYD2-1", "protein_name": "Meiotic nuclear division protein 1 homolog", "gene_name": "MND1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSKKRGLSLEEKREKMLQIFYESQDFFLLKELEKMGPKKGVISQSVKDVIQSLVDDDLVAKDKIGISIYFWSLPSCAGNQLRSVRQKLESDLQGSNKRLAELVDQCEALKKGREESEERTEALTQLKDIEKKHKDLKNEMVQFADNDPATLEAKRNAIEVAHQSANRWTDNIFTLRQWCSNNFPQAKEQLEHLYTEAGITEDFDYIELSSFPLSSSHEADTAKQLVQDEA", "length": 230 }, "evidence": [ { "id": "F1MGT0", "url": "https://omabrowser.org/oma/group/F1MGT0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q8K396-1", "protein_name": "Meiotic nuclear division protein 1 homolog", "gene_name": "Mnd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSKKRGLSGEEKRTRMMEIFFETKDVFQLKDLEKLAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKRKLEALNSQLSEGSQKHADLQKSIEKARVGRQETEERAMLAKELSSFRDQRQQLKAEVEKYRECDPQVVEEIREANKVAKEAANRWTDNIFAIKSWAKRKFGFEESKIDKNFGIPEDFDYID", "length": 205 }, "evidence": [ { "id": "F1MGT0", "url": "https://omabrowser.org/oma/group/F1MGT0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BWT6-1", "protein_name": "Meiotic nuclear division protein 1 homolog", "gene_name": "MND1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSKKKGLSAEEKRTRMMEIFSETKDVFQLKDLEKIAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKHKLEVLESQLSEGSQKHASLQKSIEKAKIGRCETEERTRLAKELSSLRDQREQLKAEVEKYKDCDPQVVEEIRQANKVAKEAANRWTDNIFAIKSWAKRKFGFEENKIDRTFGIPEDFDYID", "length": 205 }, "evidence": [ { "id": "F1MGT0", "url": "https://omabrowser.org/oma/group/F1MGT0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MGT0", "url": "https://www.uniprot.org/uniprotkb/F1MGT0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "double-stranded DNA binding", "id": "GO:0003690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", "evidence": [ { "database": "UniProtKB", "id": "F1MGT0", "url": "https://www.uniprot.org/uniprotkb/F1MGT0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "reciprocal meiotic recombination", "id": "GO:0007131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007131", "evidence": [ { "database": "UniProtKB", "id": "F1MGT0", "url": "https://www.uniprot.org/uniprotkb/F1MGT0" } ], "pmid": "" }, { "name": "meiotic cell cycle", "id": "GO:0051321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321", "evidence": [ { "database": "UniProtKB", "id": "F1MGT0", "url": "https://www.uniprot.org/uniprotkb/F1MGT0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MGT0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 205, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MGT0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MGT0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MGT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGT0" }, { "id": "PF18517", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18517" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Leucine zipper with capping helix", "eco_id": "ECO_0000259", "start_pos": 151, "end_pos": 204, "start_aa": "Val", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MGT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGT0" }, { "id": "PF03962", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03962" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Mnd1 HTH", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 75, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MDA9-1", "uniprot_ac": "F1MDA9", "uniprot_id": "F1MDA9_BOVIN", "mass": { "chemical_mass": 46562.0, "monoisotopic_mass": 46562.0 }, "refseq": {}, "gene_names": [ { "name": "NOB1", "type": "recommended", "evidence": [ { "id": "F1MDA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDA9" } ] } ], "protein_names": [ { "name": "RNA-binding protein NOB1", "type": "recommended", "evidence": [ { "id": "F1MDA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDA9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May play a role in mRNA degradation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T7U2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U2#function" }, { "database": "UniProtKB", "id": "PIRNR037125", "url": "https://www.uniprot.org/uniprotkb/PIRNR037125#function" } ] }, { "annotation": "May play a role in mRNA degradation. Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NEN5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEN5#function" }, { "database": "UniProtKB", "id": "ARBA00045628", "url": "https://www.uniprot.org/uniprotkb/ARBA00045628#function" }, { "database": "UniProtKB", "id": "F1MDA9", "url": "https://www.uniprot.org/uniprotkb/F1MDA9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MDA9", "url": "https://www.uniprot.org/uniprotkb/F1MDA9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOB1", "url": "https://www.uniprot.org/uniprotkb/F1MDA9", "locus": { "chromosome": "18", "start_pos": 36812458, "end_pos": 36829147, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020633", "url": "https://www.ensembl.org/id/ENSBTAG00000020633" } ] } } ], "crossref": [ { "id": "F1MDA9", "url": "https://alphafold.ebi.ac.uk/entry/F1MDA9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020633", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020633", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09876", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09876", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033411", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033411", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033461", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033461", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GYELECE", "url": "https://omabrowser.org/oma/group/GYELECE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MDA9", "url": "https://www.orthodb.org/?gene=F1MDA9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12814", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12814", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12814:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12814:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08772", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08772", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17146", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17146", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1NEN5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NEN5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEN5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7U2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7U2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDA9", "url": "https://www.uniprot.org/uniprotkb/F1MDA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDA9-1", "url": "https://www.uniprot.org/uniprotkb/F1MDA9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPVEHVVADAGAFLLDAALQDIGKNIYTIRNVISEIRDKATRRRLAVLPYELRFKEPFPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPEKVKVSSSIQHPETPLHVSGFHLPSKPKPPRETVEHRHPASEPEDLEFSSFMFWRNPLPNIDCELQELLMDGGEDVPNEEEDEENGLDERQDQDSDDDGGGWITPSNIKQIQQEMKQCAVPKDVRVGCVTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCAHCGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSRKARQKTDVFAPDYVAGVSPFAENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR", "length": 413, "header": "tr|F1MDA9-1|F1MDA9_BOVIN Isoform 1 of RNA-binding protein NOB1 OS=Bos taurus OX=9913 GN=NOB1 PE=3 SV=1 CANONICAL=F1MDA9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NEN5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEN5/entry", "sequence": { "sequence": "MCCYFLLQGILPTQGSNPGARIGTERLAEDPRACAVWPRWANMAPVEHVVADAGAFLLDAALQDIGKNIYTIRNVISEIRDKATRRRLAVLPYELRFKEPFPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPEKVKVSSSIQHPETPLHVSGFHLPSKPKPPRETVEHRHPASEPEDLEFSSFMFWRNPLPNIDCELQELLMDGGEDVPNEEEDEENGLDERQDQDSDDDGGGWITPSNIKQIQQEMKQCAVPKDVRVGCVTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCAHCGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSRKARQKTDVFAPDYVAGVSPFAENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR", "length": 455, "header": "tr|A0A3Q1NEN5-1|F1MDA9_BOVIN Computationally mapped isoform of RNA-binding protein NOB1 OS=Bos taurus OX=9913 GN=NOB1 PE=3 SV=1 CANONICAL=F1MDA9-1" }, "locus": { "chromosome": "18", "start_pos": 36822643, "end_pos": 36812790, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073783.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073783.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070112.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070112.2" } ] } }, { "isoform_ac": "A0AAA9T7U2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7U2/entry", "sequence": { "sequence": "MRFSRQEYWGARIGTERLAEDPRACAVWPRWANMAPVEHVVADAGAFLLDAALQDIGKNIYTIRNVISEIRDKATRRRLAVLPYELRFKEPFPEYVRLDIQVLALTYQLEAEFVGVSHLKQEPEKVKVSSSIQHPETPLHVSGFHLPSKPKPPRETVEHRHPASEPEDLEFSSFMFWRNPLPNIDCELQELLMDGGEDVPNEEEDEENGLDERQDQDSDDDGGGWITPSNIKQIQQEMKQCAVPKDVRVGCVTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCAHCGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSRKARQKTDVFAPDYVAGVSPFAENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR", "length": 429, "header": "tr|A0AAA9T7U2-1|F1MDA9_BOVIN Computationally mapped isoform of RNA-binding protein NOB1 OS=Bos taurus OX=9913 GN=NOB1 PE=3 SV=1 CANONICAL=F1MDA9-1" }, "locus": { "chromosome": "18", "start_pos": 36825843, "end_pos": 36812790, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133183.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133183.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094802.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094802.1" } ] } }, { "isoform_ac": "F1MDA9-1", "url": "https://www.uniprot.org/uniprotkb/F1MDA9/entry", "sequence": { "sequence": "MAPVEHVVADAGAFLLDAALQDIGKNIYTIRNVISEIRDKATRRRLAVLPYELRFKEPFPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPEKVKVSSSIQHPETPLHVSGFHLPSKPKPPRETVEHRHPASEPEDLEFSSFMFWRNPLPNIDCELQELLMDGGEDVPNEEEDEENGLDERQDQDSDDDGGGWITPSNIKQIQQEMKQCAVPKDVRVGCVTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCAHCGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSRKARQKTDVFAPDYVAGVSPFAENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR", "length": 413, "header": "tr|F1MDA9-1|F1MDA9_BOVIN Isoform 1 of RNA-binding protein NOB1 OS=Bos taurus OX=9913 GN=NOB1 PE=3 SV=1 CANONICAL=F1MDA9-1" }, "locus": { "chromosome": "18", "start_pos": 36822039, "end_pos": 36812790, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027497.3", "url": "https://www.ensembl.org/id/ENSBTAT00000027497.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027497.2", "url": "https://www.ensembl.org/id/ENSBTAP00000027497.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NRU5-1", "protein_name": "RNA-binding protein NOB1", "gene_name": "NOB1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARVPHVVADAGAFLSGAALQDVAQSVYTVPEVLAEIRDRRARRRLAALPYELQLRRPRADFVRTVTEFAKRTGDFPSLSAADLQVLALTCQLQAETAGPGSVRLQPPDKVRLSSSPRHPEATLHLAGFHLPAKHKRPRKGRQQHGPDSSTELPDNAEFGSFLYWRPPLPSIEDELQEMLKTHSISSSPAATDELQNSEDGDGAEEEEDDEEESDDDNEGWITPSNLKQVQQDTGHCDTVPANVQVGCVTTDFSMQNVLLQMGLHVLAVNGMLIRQARSHILRCHGCFRTTSDMTKVFCPHCGNKTLKKVAVSVSEDGSLHMHFSRNPKVLNPRGLRYPLPAPQGGKHANNPHLVEDQPFPQQRLSRKARQKTNVFDPDYVAGVSPFAENDIYSRAANLQIRDRALGAGRRRLNPNAVTKKFVKRR", "length": 426 }, "evidence": [ { "id": "F1MDA9", "url": "https://omabrowser.org/oma/group/F1MDA9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S396-1", "protein_name": "RNA-binding protein NOB1", "gene_name": "NOB1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPVEHVVADAGAFLQNAALQDIGKNIYTIRDVVSEIRDKATRRRLAVLPYELRFKEPFPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPEKVKVSSSSQHPETPLHISGFHLPSKPKRPQETVEHGEPARASEDLEFTSFVFWRNPLPDIDRDLQELLIDGGGCVPSEEEKEEDGLEEGKDQDSDDDGGGWITPSNIKQIQQELERCSVPKDVRVGCVTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCSHCGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPAPKGGKYAINPHLTEDQRFPQLRLSRKARQKTDVFAPDYVAGVSPFAENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR", "length": 413 }, "evidence": [ { "id": "F1MDA9", "url": "https://omabrowser.org/oma/group/F1MDA9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "I3ISV3-1", "protein_name": "RNA-binding protein NOB1", "gene_name": "nob1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVATIVEHVVVDAGAFIKRAPLHEIGKNIYTLKDVVDEIRDKPTKRSLAFLPYKLDFKEPFPEYIQFVTEFAKKTGDYPSLSATDIKVLALTYQLESENVGTEHLKKEPEKQVQICSTQRHPETPVGIAGFHFPSKSSGKSAIQSPPTTNEPHDPVSSQFNTFQFWRNPLPSIESELLELLAADAITVTQKLESVNLSAESEEHEGNNGEQHEEEEEEEFNSDDEEEEEDDEDGGGWITPSNIKQVQMDAGVRGPSADVKVGCVTTDFAMQNVLIQIGLNVLSVNGMLIKNTRSYILRCHACFKTTTNMNKSFCPNCGNNTLKKIAVTLNEDGTMQMHFSRNPKVLNPKGKRYSLPMPQGGKHGNNPHLVEDQRFPQQRMSRKARQKTNVFDPDYLASSSPFSEHDVYSKSASLQLRDGQTGGGRRRTNPNAARKKFVKK", "length": 440 }, "evidence": [ { "id": "F1MDA9", "url": "https://omabrowser.org/oma/group/F1MDA9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q08444-1", "protein_name": "20S-pre-rRNA D-site endonuclease NOB1", "gene_name": "NOB1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTENQTAHVRALILDATPLITQSYTHYQNYAQSFYTTPTVFQEIKDAQARKNLEIWQSLGTLKLVHPSENSIAKVSTFAKLTGDYSVLSANDLHILALTYELEIKLNNGDWRLRKKPGDALDASKADVGTDGKQKLTEDNKKEEDSESVPKKKNKRRGGKKQKAKREAREAREAENANLELESKAEEHVEEAGSKEQICNDENIKESSDLNEVFEDADDDGDWITPENLTEAIIKDSGEDTTGSLGVEASEEDRHVALNRPENQVALATGDFAVQNVALQMNLNLMNFMSGLKIKRIRNYMLRCHACFKIFPLPKDGKPKHFCASCGGQGTLLRCAVSVDSRTGNVTPHLKSNFQWNNRGNRYSVASPLSKNSQKRYGKKGHVHSKPQENVILREDQKEYEKVIKQEEWTRRHNEKILNNWIGGGSADNYISPFAITGLKQHNVRIGKGRYVNSSKRRS", "length": 459 }, "evidence": [ { "id": "F1MDA9", "url": "https://omabrowser.org/oma/group/F1MDA9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54W91-1", "protein_name": "RNA-binding protein NOB1", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSEPIENNIVDKQQEEEEEVEYEELTEEQLKELNELNENSNDNPFGERSVTAESDELVKSMETLAMTNEKTTASYLIIDTNALISGTRLETLGKELWTIPEVLEEVKDKKTSTFLTSFPFEIKTRQPTHESMVAVSEFSKKTGDYPSLSATDMKLIALTYTFEAQVNGIDHIKTEPEKLQVVTKKPVHKKNNNNNNNNNNNNKKDNKSESASESNTTTESTTTTTTTTSTATTTTTADKPKKKKNKNKNKKSKPISTDNKNIESTTTDSCCDHKHEEKEEEKVEKVEQVEKVEKVEKVEEEKESVNNNNNNTNNNNDNNNNNITGKKKRNNKLMVNLEKIEEEVSKENLVDPKEVLRQLKIKQAEEAEERKKNRVIKVEDEGEWITPDNIKNKLSSTYVQEKVHYDVGCITRDFSMQNVILQMGLHLISADGVVIKQVKQFVLKCVACLNITTDMDKIFCGHCGNKSLYKATTYVDRNGNQRVSVGSAKQFNLRGTIYSIPKPKGGKKSNDIILTEDQYLHKLRVTGQLYKKKVSKEINMNDLDLGFGHKGPSDDIVIGYGNKNPNVARKRIGKKNKSISIF", "length": 582 }, "evidence": [ { "id": "F1MDA9", "url": "https://omabrowser.org/oma/group/F1MDA9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6VEU1-1", "protein_name": "RNA-binding protein NOB1", "gene_name": "Nob1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPVEHVVADAGAFLRDAPLQDIGKNIYTIREVVREIRDKATRRRLAVLPYELRFKEPFPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKKEPEKVKVSSSIQHPETPLHISGFHLPSKSKALQETVDHGPPADGSENLEFSSFMFWRNPLPNIDHELQQLLIDGREEEEEEEEEEEEEDELEDSDDDGGGWITPSNIKQIQHESEQCDIPKDVQVGCVTTDFAMQNVLLQMGLHVLAVNGMLVREARSYILRCHGCFKTTSDMNRVFCGHCGNKTLKKVSVTINDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAVNPHLTEDQRFPQLRLSHKARQKTNVFAPDYIAGVSPFAENDISSRSAILQVRDSMLGAGRRRLNPNASRKKFVKKR", "length": 410 }, "evidence": [ { "id": "F1MDA9", "url": "https://omabrowser.org/oma/group/F1MDA9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BW10-1", "protein_name": "RNA-binding protein NOB1", "gene_name": "Nob1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPVEHVVADAGAFLRDAPLQDIGKNIYTIREVVREIRDKATRRRLAVLPYQLRFKEPLPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKKEPEKAKVSSSIQHPETALHISGFHLPSKSKPLQEAVDRGHAADGPENLEFSSFMFWRTPLPNIDRELQELLIDGREEEEEEEECEDSDDDGGGWITPSNIKQIQQELEQCDTPEDVQVGCVTTDFAMQNVLLQMGLHVLAVNGMLVREARSYILRCHGCFKTTSDMNRVFCGHCGNKTLKKVSVTINDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSQKARQKTDVFAPDYIAGVSPFAENDISSRSAILQVRDGMLGAGRRRLNPNASRKKFVKKR", "length": 403 }, "evidence": [ { "id": "F1MDA9", "url": "https://omabrowser.org/oma/group/F1MDA9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FLL1-1", "protein_name": "RNA-binding NOB1-like protein", "gene_name": "NOB1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDPKPTSMWSSIVKKDPPSKPPVNDGAPAAILGMVGNCKSTKGISIAVVDANAIIEGRQSLTNFADKFVTVPEVLSEIRDPASRRRLAFIPFTIDTMEPSPESLSKVIKFARATGDLQSLSDVDLKLIALSYTLEAQVYGTKNLRDVPPPIQTVRVKRLPEKDLPGWGSNVANLEEWEALENETEEKSNANSKILPLKDLNMNIIASDNVSEVGSVVSHTENHEEDVQEGGKKHRRYPPKKTEIKLEGKMVVEGVDASQGQYDDDDDASDWRPAVSRSTHSKYLRRKARWEHYNALAEQEIQKDQEADKARHTKEANETHAKDSGKNGEDISSILKDMRLEEESLRALQEETEETNAEATLINGEDDIDHDIEVEAEGIDVANQALENLEIASEAEDTFEASSIGDDGSSEQSWSLRALSESSVACITGDYAMQNVILQMGLRLLAPGGMQIRQLHRWILKCHACYTVTPEIGRIFCPKCGNGGTLRKVAVTIGANGAIIAACKPRITLRGTQYSIPMPKGGREAITKNLILREDQLPQKLLHPRTKKKASKPGDEYFVSDDVFLNHHSDRKAPLQPPVRKAMSVFSQKRNPNDNHYSRSMH", "length": 602 }, "evidence": [ { "id": "F1MDA9", "url": "https://omabrowser.org/oma/group/F1MDA9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9ULX3-1", "protein_name": "RNA-binding protein NOB1", "gene_name": "NOB1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPVEHVVADAGAFLRHAALQDIGKNIYTIREVVTEIRDKATRRRLAVLPYELRFKEPLPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPQKVKVSSSIQHPETPLHISGFHLPYKPKPPQETEKGHSACEPENLEFSSFMFWRNPLPNIDHELQELLIDRGEDVPSEEEEEEENGFEDRKDDSDDDGGGWITPSNIKQIQQELEQCDVPEDVRVGCLTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCSHCGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLRLSQKARQKTNVFAPDYIAGVSPFVENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR", "length": 412 }, "evidence": [ { "id": "F1MDA9", "url": "https://omabrowser.org/oma/group/F1MDA9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W2Y4-1", "protein_name": "RNA-binding protein NOB1", "gene_name": "Dmel\\CG2972", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAETSEKIKFLVADTTAFINAVPLNEYAEQVLTVPDVVAEVRNKRQIRRLCVLPFDLQVREPRPESIKHCVEFAKKTGDYASLSGIDLKVISLTYELEADNVGTDHLRQEPVMAQTIASKDKPEEMQDANNKRLVGWYMPEGEEEEEEDSEEEDDYSQEEDDAEGDEQEANESPDTVKAAIEAQLAGKEPFASETIEKEEDQDQEPSQEELDKLFEQLKCAPSAEEEKELSELLVSQPAEVDEEVSEPQEAKQSQNLDEDVGDDGWITHSNIKKAKKALEGKVETDEVPPVACMTTDYALQNVLKQLNLHLAALNGRIIKQLRTYILRCYACYKTTSIMTKVFCPNCGNKTLKRVAVSLDENGRQVIHINTRRPLTNKYKNQSLPRFQGGKHSRNPILFEDQPMPRQMPSRVAKTKTNALDQDYTAGFSPFVLRDVDSKSAMLRSKGNLKEWARNNNFEEDRRRKNYNRLYK", "length": 472 }, "evidence": [ { "id": "F1MDA9", "url": "https://omabrowser.org/oma/group/F1MDA9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MDA9", "url": "https://www.uniprot.org/uniprotkb/F1MDA9" } ], "pmid": "" }, { "name": "preribosome, small subunit precursor", "id": "GO:0030688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030688", "evidence": [ { "database": "UniProtKB", "id": "F1MDA9", "url": "https://www.uniprot.org/uniprotkb/F1MDA9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MDA9", "url": "https://www.uniprot.org/uniprotkb/F1MDA9" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "F1MDA9", "url": "https://www.uniprot.org/uniprotkb/F1MDA9" } ], "pmid": "" }, { "name": "RNA endonuclease activity", "id": "GO:0004521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004521", "evidence": [ { "database": "UniProtKB", "id": "F1MDA9", "url": "https://www.uniprot.org/uniprotkb/F1MDA9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MDA9", "url": "https://www.uniprot.org/uniprotkb/F1MDA9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "ribosomal small subunit biogenesis", "id": "GO:0042274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042274", "evidence": [ { "database": "UniProtKB", "id": "F1MDA9", "url": "https://www.uniprot.org/uniprotkb/F1MDA9" } ], "pmid": "" }, { "name": "maturation of SSU-rRNA", "id": "GO:0030490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030490", "evidence": [ { "database": "UniProtKB", "id": "F1MDA9", "url": "https://www.uniprot.org/uniprotkb/F1MDA9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MDA9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 413, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MDA9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MDA9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [ { "evidence": [ { "id": "PIRSR037125-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR037125-1" } ], "binding_site_uniprot": 287, "amino_acid": "Ala", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 287, "end_pos": 287, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR037125-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR037125-1" } ], "binding_site_uniprot": 290, "amino_acid": "Gly", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 290, "end_pos": 290, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR037125-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR037125-1" } ], "binding_site_uniprot": 302, "amino_acid": "Ser", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 302, "end_pos": 302, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR037125-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR037125-1" } ], "binding_site_uniprot": 305, "amino_acid": "Gly", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 305, "end_pos": 305, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR037125-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR037125-1" } ], "binding_site_uniprot": 313, "amino_acid": "Arg", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": "ECO_0000256", "start_pos": 313, "end_pos": 313, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "PIRSR037125-1", "database": "PIR Site Rule", "url": "https://proteininformationresource.org/cgi-bin/pirrule?id=PIRSR037125-1" } ], "binding_site_uniprot": 316, "amino_acid": "Lys", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "", "eco_id": 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1 of Signal transducer and activator of transcription OS=Bos taurus OX=9913 GN=STAT1 PE=3 SV=4 CANONICAL=E1BPP7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1ME65-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ME65/entry", "sequence": { "sequence": "MIGGSRRRRGVRICLFFPLILSLCCAEFADRSCRTREDASQIQDRAEATWERRHGCVLAHLCGIRRAEMSQWYELQQLESKYLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIICNCLKEERKILDHAQRISQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMSIEHEIKTLEDLQDEYDFKCKTLQNREHETNGVAKNDQKQEQLLLQKMYLMLDNKRKEVVLKIIELLNATELTQKALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQALWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGARTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLNPPCARWSQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLALWNDGCIVGFISKERERALLKDQQPGTFLLRFSESCREGAITFTWVERSQNGGEPYFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKFLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRMVGSVEFDMMNAV", "length": 817, "header": "tr|A0A3Q1ME65-1|A0A3Q1ME65_BOVIN Computationally mapped isoform of Signal transducer and activator of transcription OS=Bos taurus OX=9913 GN=STAT1 PE=3 SV=1 CANONICAL=E1BPP7-1" }, "locus": { "chromosome": "2", "start_pos": 79556694, "end_pos": 79518744, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084342.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084342.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067158.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067158.1" } ] } }, { "isoform_ac": "A0A3S5ZPJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPJ6/entry", "sequence": { "sequence": "MSQWYELQQLESKYLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIICNCLKEERKILDHAQRISQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMSIEHEIKTLEDLQDEYDFKCKTLQNREHETNGVAKNDQKQEQLLLQKMYLMLDNKRKEVVLKIIELLNATELTQKALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQALWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGARTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLNPPCARWSQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLALWNDGCIVGFISKERERALLKDQQPGTFLLRFSESCREGAITFTWVERSQNGGEPYFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKFLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRMVGSVEFDMRFGEPQRNTFTCFMFES", "length": 762, "header": "tr|A0A3S5ZPJ6-1|E1BPP7_BOVIN Computationally mapped isoform of Signal transducer and activator of transcription OS=Bos taurus OX=9913 GN=STAT1 PE=3 SV=2 CANONICAL=E1BPP7-1" }, "locus": { "chromosome": "2", "start_pos": 79553213, "end_pos": 79522355, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010351.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010351.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010351.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010351.7" } ] } }, { "isoform_ac": "A0AAA9SIU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIU1/entry", "sequence": { "sequence": "MSQWYELQQLESKYLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIICNCLKEERKILDHAQRISQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMSIEHEIKTLEDLQDEYDFKCKTLQNREHETNGVAKNDQKQEQLLLQKMYLMLDNKRKEVVLKIIELLNATELTQKALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQALWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGARTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLNPPCARWSQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLALWNDGCIVGFISKERERALLKDQQPGTFLLRFSESCREGAITFTWVERSQNGGEPYFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKFLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRMVGSVEFDMMNAV", "length": 729, "header": "tr|A0AAA9SIU1-1|E1BPP7_BOVIN Computationally mapped isoform of Signal transducer and activator of transcription OS=Bos taurus OX=9913 GN=STAT1 PE=3 SV=1 CANONICAL=E1BPP7-1" }, "locus": { "chromosome": "2", "start_pos": 79553213, "end_pos": 79518744, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091618.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091618.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083699.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083699.1" } ] } }, { "isoform_ac": "A0AAA9THH3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THH3/entry", "sequence": { "sequence": "MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQGDKNSALMNQEVLTLQEMLNSLDFKRKEALSKMTQIVNETDLLMNSMLVEELQDWKRRQQIACIGGPLHSGLDQLQNCFTLLAESLFQLRRQLEKLEEQSSKMTYEGDPIPLQRAHLLERVTFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNASTLSNRRFVLCGTHVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGNKGNEGCHMVTEELHSITFETQICLYGLTIDLETCSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSATLSQLLEVMSWQFSSYVGRGLNSDQLNMLAEKLTVQSSYNDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSENGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTEKGDKGYVPSVFIPISTISSSRSDSTEPHSPSDLLPMSPSVYAVLRENLSPTTIETAVCSLSFHCFQGHFSGSEGGM", "length": 763, "header": "tr|A0AAA9THH3-1|E1BPP7_BOVIN Computationally mapped isoform of Signal transducer and activator of transcription OS=Bos taurus OX=9913 GN=STAT1 PE=3 SV=1 CANONICAL=E1BPP7-1" }, "locus": { "chromosome": "2", "start_pos": 79670661, "end_pos": 79573501, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128022.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128022.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096316.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096316.1" } ] } }, { "isoform_ac": "A0AAA9TLH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLH0/entry", "sequence": { "sequence": "MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQGDKNSALMNQEVLTLQEMLNSLDFKRKEALSKMTQIVNETDLLMNSMLVEELQDWKRRQQIACIGGPLHSGLDQLQNCFTLLAESLFQLRRQLEKLEEQSSKMTYEGDPIPLQRAHLLERVTFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNASTLSNRRFVLCGTHVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGNKGNEGCHMVTEELHSITFETQICLYGLTIDLENLVFFNNPPSATLSQLLEVMSWQFSSYVGRGLNSDQLNMLAEKLTVQSSYNDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSENGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTEKGDKGYVPSVFIPISTISSSRSDSTEPHSPSDLLPMSPSVYAVLRENLSPTTIETAMKSPYSAE", "length": 718, "header": "tr|A0AAA9TLH0-1|E1BPP7_BOVIN Computationally mapped isoform of Signal transducer and activator of transcription OS=Bos taurus OX=9913 GN=STAT1 PE=3 SV=1 CANONICAL=E1BPP7-1" }, "locus": { "chromosome": "2", "start_pos": 79670661, "end_pos": 79569099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102600.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102600.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099275.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099275.1" } ] } }, { "isoform_ac": "A0AAA9TWH0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH0/entry", "sequence": { "sequence": "MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQGDKNSALMNQEVLTLQEMLNSLDFKRKEALSKMTQIVNETDLLMNSMLVEELQDWKRRQQIACIGGPLHSGLDQLQNCFTLLAESLFQLRRQLEKLEEQSSKMTYEGDPIPLQRAHLLERVTFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNASTLSNRRFVLCGTHVKAMSIEESSNGSLSVEFRHLGCHMVTEELHSITFETQICLYGLTIDLETCSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSATLSQLLEVMSWQFSSYVGRGLNSDQLNMLAEKLTVQSSYNDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSENGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTEKGDKGYVPSVFIPISTISSSRSDSTEPHSPSDLLPMSPSVYAVLRENLSPTTIETAMKSPYSAE", "length": 736, "header": "tr|A0AAA9TWH0-1|E1BPP7_BOVIN Computationally mapped isoform of Signal transducer and activator of transcription OS=Bos taurus OX=9913 GN=STAT1 PE=3 SV=1 CANONICAL=E1BPP7-1" }, "locus": { "chromosome": "2", "start_pos": 79670661, "end_pos": 79569099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091249.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091249.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102668.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102668.1" } ] } }, { "isoform_ac": "A0ABI0P2N7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2N7/entry", "sequence": { "sequence": "MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQGDKNSALMNQEVLTLQEMLNSLDFKRKEALSKMTQIVNETDLLMNSMLVEELQDWKRRQQIACIGGPLHSGLDQLQNCFTLLAESLFQLRRQLEKLEEQSSKMTYEGDPIPLQRAHLLERVTFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNASTLSNRRFVLCGTHVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGNKGNEGCHMVTEELHSITFETQICLYGLTIDLETCSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSATLSQLLEVMSWQFSSYVGRGLNSDQLNMLAEKLTVQSSYNDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSENGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEG", "length": 682, "header": "tr|A0ABI0P2N7-1|A0ABI0P2N7_BOVIN Computationally mapped isoform of Signal transducer and activator of transcription OS=Bos taurus OX=9913 GN=STAT4 PE=3 SV=1 CANONICAL=E1BPP7-1" }, "locus": { "chromosome": "2", "start_pos": 79670661, "end_pos": 79576290, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000148130.1", "url": "https://www.ensembl.org/id/ENSBTAT00000148130.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105775.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105775.1" } ] } }, { "isoform_ac": "E1BPP7-1", "url": "https://www.uniprot.org/uniprotkb/E1BPP7/entry", "sequence": { "sequence": "MSQWYELQQLESKYLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIICNCLKEERKILDHAQRISQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMSIEHEIKTLEDLQDEYDFKCKTLQNREHETNGVAKNDQKQEQLLLQKMYLMLDNKRKEVVLKIIELLNATELTQKALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQALWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGARTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLNPPCARWSQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLALWNDGCIVGFISKERERALLKDQQPGTFLLRFSESCREGAITFTWVERSQNGGEPYFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKFLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRMVGSVEFDMMNAV", "length": 749, "header": "tr|E1BPP7-1|E1BPP7_BOVIN Isoform 1 of Signal transducer and activator of transcription OS=Bos taurus OX=9913 GN=STAT1 PE=3 SV=4 CANONICAL=E1BPP7-1" }, "locus": { "chromosome": "2", "start_pos": 79553213, "end_pos": 79518744, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061553.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061553.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053390.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053390.4" } ] } }, { "isoform_ac": "F1N0R2-1", "url": "https://www.uniprot.org/uniprotkb/F1N0R2/entry", "sequence": { "sequence": "MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAASNNETMATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYKTIQTMDQGDKNSALMNQEVLTLQEMLNSLDFKRKEALSKMTQIVNETDLLMNSMLVEELQDWKRRQQIACIGGPLHSGLDQLQNCFTLLAESLFQLRRQLEKLEEQSSKMTYEGDPIPLQRAHLLERVTFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNASTLSNRRFVLCGTHVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGNKGNEGCHMVTEELHSITFETQICLYGLTIDLETCSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSATLSQLLEVMSWQFSSYVGRGLNSDQLNMLAEKLTVQSSYNDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSENGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQPCEVSRPTEKGDKGYVPSVFIPISTISSSRSDSTEPHSPSDLLPMSPSVYAVLRENLSPTTIETAMKSPYSAE", "length": 751, "header": "tr|F1N0R2-1|E1BPP7_BOVIN Computationally mapped isoform of Signal transducer and activator of transcription OS=Bos taurus OX=9913 GN=STAT1 PE=3 SV=3 CANONICAL=E1BPP7-1" }, "locus": { "chromosome": "2", "start_pos": 79670661, "end_pos": 79569099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000030584.5", "url": "https://www.ensembl.org/id/ENSBTAT00000030584.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000030561.5", "url": "https://www.ensembl.org/id/ENSBTAP00000030561.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515988", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515988", "resource": "KEGG Pathway" }, { "id": "R-BTA-1059683", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1059683", "resource": "Reactome", "description": "Interleukin-6 signaling" }, { "id": "R-BTA-1169408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1169408", "resource": "Reactome", "description": "ISG15 antiviral mechanism" }, { "id": "R-BTA-1433557", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1433557", "resource": "Reactome", "description": "Signaling by SCF-KIT" }, { "id": "R-BTA-186763", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-186763", "resource": "Reactome", "description": "Downstream signal transduction" }, { "id": "R-BTA-6785807", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6785807", "resource": "Reactome", "description": "Interleukin-4 and Interleukin-13 signaling" }, { "id": "R-BTA-877300", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-877300", "resource": "Reactome", "description": "Interferon gamma signaling" }, { "id": "R-BTA-877312", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-877312", "resource": "Reactome", "description": "Regulation of IFNG signaling" }, { "id": "R-BTA-8854691", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854691", "resource": "Reactome", "description": "Interleukin-20 family signaling" }, { "id": "R-BTA-8984722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8984722", "resource": "Reactome", "description": "Interleukin-35 Signalling" }, { "id": "R-BTA-8985947", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8985947", "resource": "Reactome", "description": "Interleukin-9 signaling" }, { "id": "R-BTA-9020591", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020591", "resource": "Reactome", "description": "Interleukin-12 signaling" }, { "id": "R-BTA-9020933", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020933", "resource": "Reactome", "description": "Interleukin-23 signaling" }, { "id": "R-BTA-9020956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020956", "resource": "Reactome", "description": "Interleukin-27 signaling" }, { "id": "R-BTA-9020958", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020958", "resource": "Reactome", "description": "Interleukin-21 signaling" }, { "id": "R-BTA-909733", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-909733", "resource": "Reactome", "description": "Interferon alpha/beta signaling" }, { "id": "R-BTA-912694", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-912694", "resource": "Reactome", "description": "Regulation of IFNA/IFNB signaling" }, { "id": "R-BTA-9833482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9833482", "resource": "Reactome", "description": "PKR-mediated signaling" }, { "id": "R-BTA-9860927", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9860927", "resource": "Reactome", "description": "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PNV3-1", "protein_name": "Signal transducer and activator of transcription", "gene_name": "STAT4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": 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"ubiquitin-like protein ligase binding", "id": "GO:0044389", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044389", "evidence": [ { "database": "UniProtKB", "id": "E1BPP7", "url": "https://www.uniprot.org/uniprotkb/E1BPP7" } ], "pmid": "" }, { "name": "tumor necrosis factor receptor binding", "id": "GO:0005164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005164", "evidence": [ { "database": "UniProtKB", "id": "E1BPP7", "url": "https://www.uniprot.org/uniprotkb/E1BPP7" } ], "pmid": "" }, { "name": "promoter-specific chromatin binding", "id": "GO:1990841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990841", "evidence": [ { "database": "UniProtKB", "id": "E1BPP7", "url": "https://www.uniprot.org/uniprotkb/E1BPP7" } ], "pmid": "" }, { "name": "histone acetyltransferase binding", "id": "GO:0035035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035035", "evidence": [ { "database": "UniProtKB", "id": "E1BPP7", "url": "https://www.uniprot.org/uniprotkb/E1BPP7" } ], "pmid": "" }, { "name": "transcription corepressor binding", "id": "GO:0001222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001222", "evidence": [ { "database": "UniProtKB", "id": "E1BPP7", "url": "https://www.uniprot.org/uniprotkb/E1BPP7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" }, { "start_pos": 460, "end_pos": 462, "annotation": "n_glycosylation_sequon" }, { "start_pos": 483, "end_pos": 485, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPP7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 749, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPP7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPP7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP7" }, { "id": "PS50001", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50001" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH2", "eco_id": "ECO_0000259", "start_pos": 573, "end_pos": 670, "start_aa": "Trp", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 222, "end_pos": 224 }, { "start_pos": 397, "end_pos": 399 }, { "start_pos": 460, "end_pos": 462 }, { "start_pos": 483, "end_pos": 485 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPZ8-1", "uniprot_ac": "E1BPZ8", "uniprot_id": "E1BPZ8_BOVIN", "mass": { "chemical_mass": 123445.0, "monoisotopic_mass": 123445.0 }, "refseq": { "ac": "XP_002689720", "name": "GPI ethanolamine phosphate transferase 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689720" }, "gene_names": [ { "name": "PIGO", "type": "recommended", "evidence": [ { "id": "E1BPZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPZ8" } ] }, { "name": "PIGO", "type": "synonym", "evidence": [ { "id": "XP_002689720", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689720" } ] } ], "protein_names": [ { "name": "GPI ethanolamine phosphate transferase 3, catalytic subunit", "type": "recommended", "evidence": [ { "id": "E1BPZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPZ8/entry#names_and_taxonomy" } ] }, { "name": "GPI ethanolamine phosphate transferase 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002689720", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689720" } ] }, { "name": "Phosphatidylinositol-glycan biosynthesis class O protein", "type": "synonym", "evidence": [ { "id": "E1BPZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPZ8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalytic subunit of the ethanolamine phosphate transferase 3 complex that transfers an ethanolamine phosphate (EtNP) from a phosphatidylethanolamine (PE) to the 6-OH position of the third alpha-1,2-linked mannose of the a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H6) intermediate to generate a a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H7) and participates in the tenth step of the glycosylphosphatidylinositol-anchor biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M3A0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3A0#function" }, { "database": "UniProtKB", "id": "ARBA00094126", "url": "https://www.uniprot.org/uniprotkb/ARBA00094126#function" }, { "database": "UniProtKB", "id": "A0AAA9RS00", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RS00#function" }, { "database": "UniProtKB", "id": "E1BPZ8", "url": "https://www.uniprot.org/uniprotkb/E1BPZ8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPZ8", "url": "https://www.uniprot.org/uniprotkb/E1BPZ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIGO", "url": "https://www.uniprot.org/uniprotkb/E1BPZ8", "locus": { "chromosome": "8", "start_pos": 59344270, "end_pos": 59352016, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044135", "url": "https://www.ensembl.org/id/ENSBTAG00000044135" } ] } } ], "crossref": [ { "id": "E1BPZ8", "url": "https://alphafold.ebi.ac.uk/entry/E1BPZ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044135", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044135", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16023", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16023", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "783989", "url": "https://www.ncbi.nlm.nih.gov/gene/783989", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039524", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039524", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045687", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045687", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:783989", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783989", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YPSFDIF", "url": "https://omabrowser.org/oma/group/YPSFDIF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3A0", "url": "https://www.orthodb.org/?gene=A0A3Q1M3A0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BPZ8", "url": "https://www.orthodb.org/?gene=E1BPZ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23071", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23071", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23071:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23071:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01663", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01663", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19316", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19316", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002689720", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689720", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "61012", "url": "https://www.rhea-db.org/rhea/61012", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M3A0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3A0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3A0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3A0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RS00", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RS00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RS00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RS00-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPZ8", "url": "https://www.uniprot.org/uniprotkb/E1BPZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPZ8-1", "url": "https://www.uniprot.org/uniprotkb/E1BPZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQKISVLLFLAWVSFLFYAGIALFTSGFLLTRWELTNHSSCQEPPGPGALPWGGRGEPGACWMASRFSRLVLVVIDALRFDFAQPQRSPVSGEPPVSLPFLGKMGFLQRLLESQPHHARLYQAKADPPTTTMQRLKALTTGSLPTFVDAGSNFASSAIVEDNLIKQLSSTGRRVVFMGDETWNDLFPGVFSQALFFPSFNVRDLETVDNGIMKHLYPTMDSDEWDVLITHFLGVDHCGHKHDPYHPEMAKKLTQMDKMIQGLVKRLKNDTLLVVTGDHGMTISGNHGGESELETSAALFLYSPRALFPSAPAEEPEIIPQISLVPTLALLLGLPIPFGNIGEVIAEVFSEIEDSQPRFSALAQASALHLNAQQVSRFLHTYSATAQDLQVQELHRLQKLFSKASADYQRLLQSPQGAEAVLQTVIPELQQFLRGVRAMCIESWARFSLVRMAGGAALLAATCFLCLLVSQWATSPAFYFGPLLKPTASGLSGAMVCAGLLASTGLKLDSMVLGAMAAVGSLLPFLWKAWASWGSKRPLASLLPMPGPVLLLLLIRFAGFFSDSYIITEARVAPFLLISLILLLVARLHWEGKLLPPKLLSIPRLGFLTPAGPPQYSAMHAVGLGVGLLLCIRLAGLFYRCHEETPVCSSSPLLSPLRSTVDGRTKNLWYGACVGALVALLASVRLWLHCYGNLKSPEPPVLFVRWGLPLMGLGTAAYWALASGADEAPPRLRALVSGASVMLPRAVAGLAASGLMLLLWRPVTVLVKATTGAPRTRTVLTPFSGPPTSQADLDYVVPQIYRHIQEEFRGRLERTKSQGLLTVAAYQLGSVYSAAVVMALTLLAFPLLLLHAERISLVFLLLFLQSFLLLHLLAAGIPITTPGPFTVPWHAVFAWALMATQTFYTTGHQPVFSAIQWHAAFVGVSESRDFTWLSAFLVGANTFASHILFAVGCPLLLLWPFLCENQGSQKRRQPPGNEAEARVRPEEEQEPRMEMRLRDAPHHFSAALLQLGLKYLFVLGIQILACVLAASILRRHLLVWKVFAPKFIFEAMGFIVSSVGLCLGIALVMRVDGAVSSWFRQLVLTQQKAGEQSSLVCTGAGSSARKAQPHLLPPCSQDLLASGTSLFYNSRS", "length": 1131, "header": "tr|E1BPZ8-1|E1BPZ8_BOVIN Isoform 1 of GPI ethanolamine phosphate transferase 3, catalytic subunit OS=Bos taurus OX=9913 GN=PIGO PE=3 SV=3 CANONICAL=E1BPZ8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3A0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3A0/entry", "sequence": { "sequence": "MQKISVLLFLAWVSFLFYAGIALFTSGFLLTRWELTNHSSCQEPPGPGALPWGGRGEPGACWMASRFSRLVLVVIDALRFDFAQPQRSPVSGEPPVSLPFLGKMGFLQRLLESQPHHARLYQAKADPPTTTMQRLKALTTGSLPTFVDAGSNFASSAIVEDNLIKQLSSTGRRVVFMGDETWNDLFPGVFSQALFFPSFNVRDLETVDNGIMKHLYPTMDSDEWDVLITHFLGVDHCGHKHDPYHPEMAKKLTQMDKMIQGLVKRLKNDTLLVVTGDHGMTISGNHGGESELETSAALFLYSPRALFPSAPAEEPEIIPQISLVPTLALLLGLPIPFGNIGEVIAEVFSEIEDSQPRFSALAQASALHLNAQQVSRFLHTYSATAQDLQVQELHRLQKLFSKASADYQRLLQSPQGAEAVLQTVIPELQQFLRGVRAMCIESWARFSLVRMAGGPPTSQADLDYVVPQIYRHIQEEFRGRLERTKSQGLLTVAAYQLGSVYSAAVVMALTLLAFPLLLLHAERISLVFLLLFLQSFLLLHLLAAGIPITTPGPFTVPWHAVFAWALMATQTFYTTGHQPVFSAIQWHAAFVGVSESRDFTWLSAFLVGANTFASHILFAVGCPLLLLWPFLCENQGSQKRRQPPGNEAEARVRPEEEQEPRMEMRLRDAPHHFSAALLQLGLKYLFVLGIQILACVLAASILRRHLLVWKVFAPKFIFEAMGFIVSSVGLCLGIALVMRVDGAVSSWFRQLVLTQQKAGEQSSLVCTGAGSSARKAQPHLLPPCSQDLLASGTSLFYNSRS", "length": 801, "header": "tr|A0A3Q1M3A0-1|E1BPZ8_BOVIN Computationally mapped isoform of GPI ethanolamine phosphate transferase 3, catalytic subunit OS=Bos taurus OX=9913 GN=PIGO PE=3 SV=2 CANONICAL=E1BPZ8-1" }, "locus": { "chromosome": "8", "start_pos": 59351817, "end_pos": 59345274, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079143.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079143.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064568.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064568.2" } ] } }, { "isoform_ac": "A0AAA9RS00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RS00/entry", "sequence": { "sequence": "MQKISVLLFLAWVSFLFYAGIALFTSGFLLTRWELTNHSSCQEPPGPGALPWGGRGEPGACWMASRFSRLVLVVIDALRFDFAQPQRSPVSGEPPVSLPFLGKMGFLQRLLESQPHHARLYQAKADPPTTTMQRLKALTTGSLPTFVDAGSNFASSAIVEDNLIKQLSSTGRRVVFMGDETWNDLFPGVFSQALFFPSFNVRDLETVDNGIMKHLYPTMDSDEWDVLITHFLGVDHCGHKHDPYHPEMAKKLTQMDKMIQGLVKRLKNDTLLVVTGDHGMTISGNHGGESELETSAALFLYSPRALFPSAPAEVSRFLHTYSATAQDLQVQELHRLQKLFSKASADYQRLLQSPQGAEAVLQTVIPELQQFLRGVRAMCIESWARFSLSFLLLHLLAAGIPITTPGPFTVPWHAVFAWALMATQTFYTTGHQPVFSAIQWHAAFVGVSESRDFTWLSAFLVGANTFASHILFAVGCPLLLLWPFLCENQGSQKRRQPPGNEAEARVRPEEEQEPRMEMRLRDAPHHFSAALLQLGLKYLFVLGIQILACVLAASILRRHLLVWKVFAPKFIFEAMGFIVSSVGLCLGIALVMRVDGAVSSWFRQLVLTQQKAGEQSSLVCTGAGSSARKAQPHLLPPCSQDLLASGTSLFYNSRS", "length": 655, "header": "tr|A0AAA9RS00-1|E1BPZ8_BOVIN Computationally mapped isoform of GPI ethanolamine phosphate transferase 3, catalytic subunit OS=Bos taurus OX=9913 GN=PIGO PE=3 SV=1 CANONICAL=E1BPZ8-1" }, "locus": { "chromosome": "8", "start_pos": 59351817, "end_pos": 59345274, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111322.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111322.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075105.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075105.1" } ] } }, { "isoform_ac": "E1BPZ8-1", "url": "https://www.uniprot.org/uniprotkb/E1BPZ8/entry", "sequence": { "sequence": "MQKISVLLFLAWVSFLFYAGIALFTSGFLLTRWELTNHSSCQEPPGPGALPWGGRGEPGACWMASRFSRLVLVVIDALRFDFAQPQRSPVSGEPPVSLPFLGKMGFLQRLLESQPHHARLYQAKADPPTTTMQRLKALTTGSLPTFVDAGSNFASSAIVEDNLIKQLSSTGRRVVFMGDETWNDLFPGVFSQALFFPSFNVRDLETVDNGIMKHLYPTMDSDEWDVLITHFLGVDHCGHKHDPYHPEMAKKLTQMDKMIQGLVKRLKNDTLLVVTGDHGMTISGNHGGESELETSAALFLYSPRALFPSAPAEEPEIIPQISLVPTLALLLGLPIPFGNIGEVIAEVFSEIEDSQPRFSALAQASALHLNAQQVSRFLHTYSATAQDLQVQELHRLQKLFSKASADYQRLLQSPQGAEAVLQTVIPELQQFLRGVRAMCIESWARFSLVRMAGGAALLAATCFLCLLVSQWATSPAFYFGPLLKPTASGLSGAMVCAGLLASTGLKLDSMVLGAMAAVGSLLPFLWKAWASWGSKRPLASLLPMPGPVLLLLLIRFAGFFSDSYIITEARVAPFLLISLILLLVARLHWEGKLLPPKLLSIPRLGFLTPAGPPQYSAMHAVGLGVGLLLCIRLAGLFYRCHEETPVCSSSPLLSPLRSTVDGRTKNLWYGACVGALVALLASVRLWLHCYGNLKSPEPPVLFVRWGLPLMGLGTAAYWALASGADEAPPRLRALVSGASVMLPRAVAGLAASGLMLLLWRPVTVLVKATTGAPRTRTVLTPFSGPPTSQADLDYVVPQIYRHIQEEFRGRLERTKSQGLLTVAAYQLGSVYSAAVVMALTLLAFPLLLLHAERISLVFLLLFLQSFLLLHLLAAGIPITTPGPFTVPWHAVFAWALMATQTFYTTGHQPVFSAIQWHAAFVGVSESRDFTWLSAFLVGANTFASHILFAVGCPLLLLWPFLCENQGSQKRRQPPGNEAEARVRPEEEQEPRMEMRLRDAPHHFSAALLQLGLKYLFVLGIQILACVLAASILRRHLLVWKVFAPKFIFEAMGFIVSSVGLCLGIALVMRVDGAVSSWFRQLVLTQQKAGEQSSLVCTGAGSSARKAQPHLLPPCSQDLLASGTSLFYNSRS", "length": 1131, "header": "tr|E1BPZ8-1|E1BPZ8_BOVIN Isoform 1 of GPI ethanolamine phosphate transferase 3, catalytic subunit OS=Bos taurus OX=9913 GN=PIGO PE=3 SV=3 CANONICAL=E1BPZ8-1" }, "locus": { "chromosome": "8", "start_pos": 59351817, "end_pos": 59345274, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061353.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061353.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053302.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053302.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:783989", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:783989", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y584-1", "protein_name": "GPI ethanolamine phosphate transferase 3, catalytic subunit", "gene_name": "PIGO", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQRWPVLLFLAWVCFLFFSGIGLFMSGFLLTRIELANSSSCSDPLAPPPWDKQSLPPGSCWVPQRFPKVVLVIIDALRFEFALFNPAKVNPLPYENKLSFLHHLATSQPHHARLYRFLADPPTATMQRIKGLTTGSLPTFIDVGSNFATYAIQEDNLLAQLVQNGRRVVFMGDDTWEGLFPKKFFRSYFFPSFNVKDLHTVDNGILQYLYPTVNSGEWDLLIAHFLGVDHCGHKHGPDHPEMAKKLTQMNEMLRSLVDHLGNDTLLLVAGDHGMTETGDHGGDSQREVNAALFVYSKTPLFGTDPPEEPEAIPQVNLVPTVALLLGVPIPYSNIGEVMAELFSGDGDTVSEALQQLLVYHINAKQVDRFLHSYSLVAQDLPAEQLQHLQELFSSAVEEHVQLLAQVQRAMLVSPELESKLRSLISRFQLYLRQARAVCTQSWARFHPLRMVGGCTLIAASCLLCYVASELATVSDSFYRSCLLYPLLWGLMTAVLRGLACVFTQEELDLLLLLSWAAAASLLGFFWHWWGRHPKRARLLGSQPPLASIGLRQRLRVWLGLAFPVSILFFRCGAMFSDSFVVAEAQVAPFLLASLVMLLIGKLHWDGHLTVPEGPKQQALGFSSYRKESWHLLCLVAVLLVCVRLSGFFHQCREEIPQCRPSVFLPPLASLRNTRAKNLFYLLCVALLAGLVYAVRSWLRHYGNLNSSDPLVLFVRWGFPLVVLCIACYWAVASSAEDSLGKLQELVEVAIIAFPWAVYGLVSIGLLLLLCHPMTVFAKDSRESAGSIVTPYQGIPSSKVDLLQVIPQIYKRMQESEKSRLERRSCRATVAAYGLGSVYSAALVIALTLLGFLLMLLHSERLSLAFLLLFLEAFVLLHIHTRARSLAGDTEPFSVPWFSVISWLLAASQFFYSTGHQPIFPAIHWNAAFVGFHLDHSTNLLPAVLVGANTFASHILFAVGCPLLLLWPFVCEMPSSQKKKSKREPQEELQTVDEHMMEMRLRESPEKFSTALLQLGLKYLFVLGAQLLACVCAAVILRRHLMVWKVFAPKFLFESLGFMVSSICLLLGISLVMRVDCAVSTWFSQLQLR", "length": 1088 }, "evidence": [ { "id": "E1BPZ8", "url": "https://omabrowser.org/oma/group/E1BPZ8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LN10-1", "protein_name": "GPI ethanolamine phosphate transferase 3, catalytic subunit", "gene_name": "Pigo", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHTSVVPDCKHCRRTSGRESRMQKISVLLFLAWVCFLFYAGIALFTSGFLLTRLELTNQSSCQEPPGPGSLPWGSQGKPGACWMPSRFSRVVLVLIDALRFDFAQPQCSHVPGEPPVSVPFLGKLGSLKRILEVQPHHARLYQSQVDPPTTTMQRLKALTTGSLPTFIDAGSNFASHAIVEDNLIKQLTSAGKRVVFMGDDTWKDLFPGAFSQAFFFSSFNVRDLHTVDNGILEHLYPTMDSGAWDVLIAHFLGVDHCGHKHGPHHPEMAKKLSQMDQVIQGLIERLENDTLLVVAGDHGMTMNGDHGGDSELEVSAALFLYSPTVLFPSVPPEEPEVIPQISLVPTLALLLGLPIPFGNIGEVMAELFSGGSGGGSSRGDGDASHPDSPALAQVSALYINAQQVSRFLHTYSAATQDLHVKELRRLQELFSKASARYQHLLQHPREAEAALSSLTADFQQFLRGARAVCIESWARFSLVRMAGGAALLAAACLLCLLASQLAVAPGFLFRPLLLIPVAWGLTWTLLYAGVSVTTGSKLDPVVLGAVAAAGSLLPFLWKAWLSWGSKRPLAPLLPVPRPVLALLLIRLATFFSDSFVVAEARATPFLLGSLILFLVAQLHWEGQLLPPKLLTTSRLGSSAPTAPPRHSGTHALLLGIGLLLFTRLAGLFHRCPEETPACRSSPWLSPLASMVGGRAKNLWYGACVGALVALLAAVRLWLRRYGNLKSPEPPVLFVRWGLPLMVLGTAAYWALASGAEEVPPRLRALVAGASAVLPRAVMGLAASGLMLLLWRPVTVLVKAGAATSRTRTILTPFSGPPTSQADLDYVVPQIYRHMQEEFQGRLERTRAQGPITVAAYQLGSVYSAAMVTALILLAFPLLLLHVERVSLVFLLLFLQSFLLLHLLAAGTPVATPGPFTVMWQAVSAWVLLATQTFYSTGHQPVFSAIHWHAAFVGFPDGHGSSTWLPALLVGANTFASHLLFAVGCPLLLLWPFLCERQGPKKRQSLPGSESEARVRPEEEQEEPLMEMRLRDAPHHFNAALLQLGLKYLFVLGAQILACALAASILRRHLMVWKVFAPKFIFEAIGFIVSSVGLLLGIALVMRVDGAVSSWFKKLVLAQQR", "length": 1121 }, "evidence": [ { "id": "E1BPZ8", "url": "https://omabrowser.org/oma/group/E1BPZ8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A1ZB84-1", "protein_name": "GPI ethanolamine phosphate transferase 3, catalytic subunit", "gene_name": "PIG-O", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNLTYLFVLIWLAFLISSGVMLFSRGFLLARVSKTETSTCRRLSTNPNAEYVLTDEVVNEIFKDVNASSNLCLPQKSKVIVLVVDALKYEFGLYRANATDPLPYENKLVVLQELLQQNPDHARLMRFRADPPTTTLQRLKGLTTGSLPTFIDIGSNFASPEINEDNIIDQIVKNDLPVVFLGDSTWTDLYPHRFKRSYSYPSFDIFDLDSVDNEILKHLPKELESKDWQVLVAHFLGVDHCGHKHGPMHEEMARKLGEMNEVIRSVVAAMDNDTTLLVMGDHGMTASGDHGGDTDDETNALLFAYSKQHRFYGNDSGSDSEMLQQIDLVPTLATILGVPIPYSNLGLVNFNIVPDLRVPHLNKFQTLLLHSWQNAQQIYRYFFQYALENKRTFNVEQMDHLETEFILLTHRVQTVYNEVAFKSFVRDLNTNLRDILGTCREIWVRFDPTQMSQGLLFTFLPLFFIFLVVNNSRPADFPHIFKAKEVFYVYLINLAAGVFGYRYFKTFSFKTEEQGVIFFTAISSAVILAFHTLRHWTSIATNWSAVKRFGHMPTRLLLFGSMAVFFSNSFVIQEAKILSYLLAAAILLLSHELLRLSARLDFRTKFKASQFLRSTALRLILASVLAICLIRFAYTLFRCREEQGNCSDFVNTGGAGFSLKKPGTGKTYILAVVVLVVYTTLTRLYLRSCGNLTGNLPNVLLARYGPTVASICAGGHILLANSSIKHIQRTHIDAMALVIYGLLLVQIIVLSWAPLMTFVLPPRSSHTVTINGNESIVPEIFRKMKRMYEGDDDERRSHIPVVYGLATVYSSIVIAFGVFLALVMIVLLEPRASIGLVVCVAVGAILLSVHSILRYRTATSFESCVQPTFTALVGWFLLAHFCFFATSHQTTLSQIEWRAAFVGRTTGIGQSNLVSGALVILNTFCGPIFFFCMYSLLSTETFSLFALFPNLIRSCRSGGKVDASTSMSDLANEAVGFDMTRGELSLYEYEDVFLGTGFKLATQFFMLQGLKIFCAMLACTIHCRHLMVWKIFAPRFIYEALATFVSLPALIVGYLLVLRIHRGVDTLIKRINKAKVH", "length": 1077 }, "evidence": [ { "id": "E1BPZ8", "url": "https://omabrowser.org/oma/group/E1BPZ8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "E9QI13-1", "protein_name": "GPI ethanolamine phosphate transferase 3, catalytic subunit", "gene_name": "pigo", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRRLPILLALLWVCSVFYVGIFLFVGGFLLVRLEVNRMSTCADVLSPVAQLKGDFCLSEPRFRRAVVLIIDALKADFTRYDPENAAPKPFENKLPVLDEMASAHSSHARLYTFRADPPTTTMQRIKGFTTGSLPTFIDVGNNFASNAILEDNLVHQLGQVGKRVVFMGDDTWVSLFPKKFHRSLPFPSFNVKDLHTVDNGILQNIYPTMEGDDWDVLIAHFLGVDHCGHRFGPDHPAMAEKLSQMDGVIRSVIKRLKNDTLLVVMGDHGMTDTGDHGGESQKETDAALFLYSSSPLFPAPGSQVEPEVVPQTDLVPTLALLLGVPIPYSSVGQVLLPLFPQNGSRGAPTGLSQAEALWINVKQVNRFLETYSNMAKDIPPDSLSQLQADFSNISSQYLSAVHKGHLPPLKLVISMQNYLTAVRETCRASWARFNPFKMAAGLLILAVSCVLCYALSELSCVVVQEGLLKLPILSGLAVGLVIAAGQLFLQGYLEFSWCLGTAALSSEVLFLWKTRRVSQKCRWSLSGLLTPALLVLFLRCASLLSDSYVIYEGHVVTFLLFTLSIYIPLRLNWDGLLVPLPPPDTQKPPRLLPTTLPSSVVRREASVLLVWLGVLVGSLYVSLSFHNCREEQGTCQPSSFLSPLSRVQDSQLRNLHYVLSVFSLATWGYLLHRWLRHYGNLNCSSLTVFTACFLIPLACVCIGLHWAVSATPEDTFRSLSELIGLAQVFLPRAAFCLLGLGLLLLWLDPMTVFLKTRTPLSSRGTSLPPPKYRASTGISPQAELHHLIPQLYQRIRHSLEDGSTDSGEVDNRPAVEAYGLGTVYSAPLVLLCGLLGLVLLLLHPEGMALAFLLLLLEAGAVLHIHACSTTLSSLHKHSNDFSVPWAPVVSWSLAAAQFFHASGHLPTFPSIQWGAAFVGFPQGHTGNLLPASLVTLNTFASHIIFAVGCPLLLLWPLVCEVRGSRSTRSAGLEESEDAVMEMRLRENPQNFSSCLLQLAARYLFVSGAQVFASVCAAAILRRHLMVWKVFAPKLMFEAFGFIVGSVFLILGVAMVMRVDLSVGGLFKKLLPQNSR", "length": 1075 }, "evidence": [ { "id": "E1BPZ8", "url": "https://omabrowser.org/oma/group/E1BPZ8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q07830-1", "protein_name": "GPI ethanolamine phosphate transferase 3", "gene_name": "GPI13", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MDEKTIKKSILSSSNDEKIIYKSRIKKFQKNHKFYIILLVFIAILQFISIAFFTRGFLLSRHVLDNISSQNETSKLPPRFNKAVILVIDALRFDFAIPVNESHSNYNLNYHNNILSLYDSFASDKDASSLLLKFIADPPTTTLQRLKGLTTGSLPTFIDAGSNFDGTVIEEDNFLKQLHLANKTVKFAGDDTWMALFHPFLSNDSFPLESLNVWDLDTVDNGVMDYFHDHLQQDKEWDVMIGHMLGIDHVGHKYGPDHFTMREKQIQVDQFIDWILKSIDDDTLLVILGDHGMDHTGNHGGDSIDELESTLFLYSKKPDMWRLKETSNYNIDNLGHDYRSVRQIDLVSSLALLMGQPIPFNNLGWPIDEIARNDREWSQFVNSAISQLQLYKDTMQIHHGNDEILEPLAKNISNTPPTSDPEKFVKLGHKYQKVFLQTCEELWAKFDYYSIATGITLLATSLVLLISITKLIPSIVVNQMVPEFVPGIIIMVLVTNLCFHGIFYVYQQPSFVDQFWGTLLATAIGIIIGCYITIFDRYNFIWIAMRLGETLADYWSRIAVMFMIIHALLFTSNSFTIWEDRIVAFLLSTFGMLTLYEFVFLPKRQSTTALLTATISEKEGTTSGVNPSTANSNYLPLTRFARLLGGYHSAVLIIFTRLASMITICREEQGEYCIPTFNNQNNSSWWVLGLCFLMIFILPACITGYYNLTSSYQAAAPIWINVFLKGILGLNFVYWSLTSLENNSAVIAIPFLRDVTIFKFTLARIIAGFSLIASNVGWLMGPLCIKLNIHNTDVKSHEATILGYTNIYGSEFFLLVINVLISILLFNKPLAQLSYFLMCNQLLSILEIIDLLKLKENIIGPIALGLLSYQHFFTTGHQATIPSVQWDIGFMLSEKVTFPFTQIAIILNTFGPHILVSLSVALLTLWSQPPDVLKPQTLLGRIVSNCGILLTYNTILCLSSFIWVTHFRRHLMVWKIFCPRFIFASLSLIVTQLVVTFGTIAFASGRLIKHINDIFWK", "length": 1017 }, "evidence": [ { "id": "E1BPZ8", "url": "https://omabrowser.org/oma/group/E1BPZ8/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q8TEQ8-1", "protein_name": "GPI ethanolamine phosphate transferase 3, catalytic subunit", "gene_name": "PIGO", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQKASVLLFLAWVCFLFYAGIALFTSGFLLTRLELTNHSSCQEPPGPGSLPWGSQGKPGACWMASRFSRVVLVLIDALRFDFAQPQHSHVPREPPVSLPFLGKLSSLQRILEIQPHHARLYRSQVDPPTTTMQRLKALTTGSLPTFIDAGSNFASHAIVEDNLIKQLTSAGRRVVFMGDDTWKDLFPGAFSKAFFFPSFNVRDLDTVDNGILEHLYPTMDSGEWDVLIAHFLGVDHCGHKHGPHHPEMAKKLSQMDQVIQGLVERLENDTLLVVAGDHGMTTNGDHGGDSELEVSAALFLYSPTAVFPSTPPEEPEVIPQVSLVPTLALLLGLPIPFGNIGEVMAELFSGGEDSQPHSSALAQASALHLNAQQVSRFLHTYSAATQDLQAKELHQLQNLFSKASADYQWLLQSPKGAEATLPTVIAELQQFLRGARAMCIESWARFSLVRMAGGTALLAASCFICLLASQWAISPGFPFCPLLLTPVAWGLVGAIAYAGLLGTIELKLDLVLLGAVAAVSSFLPFLWKAWAGWGSKRPLATLFPIPGPVLLLLLFRLAVFFSDSFVVAEARATPFLLGSFILLLVVQLHWEGQLLPPKLLTMPRLGTSATTNPPRHNGAYALRLGIGLLLCTRLAGLFHRCPEETPVCHSSPWLSPLASMVGGRAKNLWYGACVAALVALLAAVRLWLRRYGNLKSPEPPMLFVRWGLPLMALGTAAYWALASGADEAPPRLRVLVSGASMVLPRAVAGLAASGLALLLWKPVTVLVKAGAGAPRTRTVLTPFSGPPTSQADLDYVVPQIYRHMQEEFRGRLERTKSQGPLTVAAYQLGSVYSAAMVTALTLLAFPLLLLHAERISLVFLLLFLQSFLLLHLLAAGIPVTTPGPFTVPWQAVSAWALMATQTFYSTGHQPVFPAIHWHAAFVGFPEGHGSCTWLPALLVGANTFASHLLFAVGCPLLLLWPFLCESQGLRKRQQPPGNEADARVRPEEEEEPLMEMRLRDAPQHFYAALLQLGLKYLFILGIQILACALAASILRRHLMVWKVFAPKFIFEAVGFIVSSVGLLLGIALVMRVDGAVSSWFRQLFLAQQR", "length": 1089 }, "evidence": [ { "id": "E1BPZ8", "url": "https://omabrowser.org/oma/group/E1BPZ8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "mannose-ethanolamine phosphotransferase activity", "id": "GO:0051377", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051377", "evidence": [ { "database": "UniProtKB", "id": "E1BPZ8", "url": "https://www.uniprot.org/uniprotkb/E1BPZ8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1BPZ8", "url": "https://www.uniprot.org/uniprotkb/E1BPZ8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "GPI anchor biosynthetic process", "id": "GO:0006506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006506", "evidence": [ { "database": "UniProtKB", "id": "E1BPZ8", "url": "https://www.uniprot.org/uniprotkb/E1BPZ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 268, "end_pos": 270, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "61012", "name": "", "equation": "a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "61012", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/61012" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPZ8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1131, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPZ8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPZ8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPZ8" }, { "id": "PF19316", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19316" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GPI ethanolamine phosphate transferase 2 C-terminal", "eco_id": "ECO_0000259", "start_pos": 887, "end_pos": 1056, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 268, "end_pos": 270 }, { "start_pos": 37, "end_pos": 39 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MHM5-1", "uniprot_ac": "F1MHM5", "uniprot_id": "F1MHM5_BOVIN", "mass": { "chemical_mass": 59160.0, "monoisotopic_mass": 59160.0 }, "refseq": {}, "gene_names": [ { "name": "YARS1", "type": "recommended", "evidence": [ { "id": "F1MHM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" } ] } ], "protein_names": [ { "name": "Tyrosine--tRNA ligase", "type": "recommended", "evidence": [ { "id": "F1MHM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHM5/entry#names_and_taxonomy" } ] }, { "name": "6.1.1.1", "type": "synonym", "evidence": [ { "id": "F1MHM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHM5/entry#names_and_taxonomy" } ] }, { "name": "Tyrosyl-tRNA synthetase", "type": "synonym", "evidence": [ { "id": "F1MHM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHM5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity. Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RTW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTW9#function" }, { "database": "UniProtKB", "id": "ARBA00046131", "url": "https://www.uniprot.org/uniprotkb/ARBA00046131#function" }, { "database": "UniProtKB", "id": "A0AAA9RXY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXY4#function" }, { "database": "UniProtKB", "id": "A0AAA9S1K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1K9#function" }, { "database": "UniProtKB", "id": "A0AAA9SNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV2#function" }, { "database": "UniProtKB", "id": "A0AAA9SSB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB5#function" }, { "database": "UniProtKB", "id": "F1MHM5", "url": "https://www.uniprot.org/uniprotkb/F1MHM5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MHM5", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YARS1", "url": "https://www.uniprot.org/uniprotkb/F1MHM5", "locus": { "chromosome": "2", "start_pos": 120881261, "end_pos": 120849154, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018065", "url": "https://www.ensembl.org/id/ENSBTAG00000018065" } ] } } ], "crossref": [ { "id": "F1MHM5", "url": "https://alphafold.ebi.ac.uk/entry/F1MHM5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018065", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018065", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00805", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00805", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd02799", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02799", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002307", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002307", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002547", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002547", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RKIHMLA", "url": "https://omabrowser.org/oma/group/RKIHMLA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11586", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11586", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11586:SF43", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11586:SF43", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00579", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00579", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01588", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01588", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "10220", "url": "https://www.rhea-db.org/rhea/10220", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RTW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1K9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S1K9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1K9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSB5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHM5", "url": "https://www.uniprot.org/uniprotkb/F1MHM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHM5-1", "url": "https://www.uniprot.org/uniprotkb/F1MHM5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDSLSPEEKLSLITRNLQEVLGEEKLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLRFIKGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPALGYSKRIHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLAFIRHVLFPLKSEFVILRDEKWGGNKTYTAYLDLEKDFADEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLSSAAYPDPSKQKPAVKGPAKNSEPEEVIPSRLDIRVGKVISVDKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASVEGVNRKVEPLDPPAGSAPGERVFVKGYEKGQPDEELKPKKKVFEKLQADFKISDEYIAQWKQTNFMTKLGSVSCKSLKGGNIS", "length": 528, "header": "tr|F1MHM5-1|F1MHM5_BOVIN Isoform 1 of Tyrosine--tRNA ligase OS=Bos taurus OX=9913 GN=YARS1 PE=3 SV=1 CANONICAL=F1MHM5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RTW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTW9/entry", "sequence": { "sequence": "FFTLLSPSSRTLLLPLQEVLGEEKLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLRFIKGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPALGYSKRIHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLAFIRHVLFPLKSEFVILRDEKWGGNKTYTAYLDLEKDFADEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLSSAAYPDPSKQKPAVKGPAKNSEPEEVIPSRLDIRVGKVISVDKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASVEGVNRKVEPLDPPAGSAPGERVFVKGYEKGQPDEELKPKKKVFEKLQADFKISDEYIAQWKQTNFMTKLGSVSCKSLKGGNIS", "length": 526, "header": "tr|A0AAA9RTW9-1|F1MHM5_BOVIN Computationally mapped isoform of Tyrosine--tRNA ligase OS=Bos taurus OX=9913 GN=YARS1 PE=3 SV=1 CANONICAL=F1MHM5-1" }, "locus": { "chromosome": "2", "start_pos": 120880531, "end_pos": 120853774, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129797.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129797.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075460.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075460.1" } ] } }, { "isoform_ac": "A0AAA9RXY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXY4/entry", "sequence": { "sequence": "MGDSLSPEEKLSLITRNLQEVLGEEKLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLRFIKGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPALGYSKRIHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLAFIRHVLFPLKSEFVILRDEKWGGNKTYTAYLDLEKDFADEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLSSAAYPDPSKQKPAVKGPAKNSEPEEVIPSRLDIRVGKVISVDKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASVEGVNRKVEPLDPPAGSAPGERVFVKGYEKGQPDEELKPKKKVFEKLQALRADRLLEAACEGLQLFPR", "length": 512, "header": "tr|A0AAA9RXY4-1|F1MHM5_BOVIN Computationally mapped isoform of Tyrosine--tRNA ligase OS=Bos taurus OX=9913 GN=YARS1 PE=3 SV=1 CANONICAL=F1MHM5-1" }, "locus": { "chromosome": "2", "start_pos": 120879394, "end_pos": 120849244, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097287.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097287.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074674.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074674.1" } ] } }, { "isoform_ac": "A0AAA9S1K9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1K9/entry", "sequence": { "sequence": "MGDSLSPEEKLSLITRNLQEVLGEEKLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLRFIKGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLAFIRHVLFPLKSEFVILRDEKWGGNKTYTAYLDLEKDFADEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLSSAAYPDPSKQKPAVKGPAKNSEPEEVIPSRLDIRVGKVISVDKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASVEGVNRKVEPLDPPAGSAPGERVFVKGYEKGQPDEELKPKKKVFEKLQADFKISDEYIAQWKQTNFMTKLGSVSCKSLKGGNIS", "length": 497, "header": "tr|A0AAA9S1K9-1|F1MHM5_BOVIN Computationally mapped isoform of Tyrosine--tRNA ligase OS=Bos taurus OX=9913 GN=YARS1 PE=3 SV=1 CANONICAL=F1MHM5-1" }, "locus": { "chromosome": "2", "start_pos": 120880531, "end_pos": 120849244, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128562.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128562.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077568.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077568.1" } ] } }, { "isoform_ac": "A0AAA9SNV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNV2/entry", "sequence": { "sequence": "MGDSLSPEEKLSLITRNLQEVLGEEKLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLRFIKGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPALGYSKRIHLMNPMVPGLTGSKMSSSEEIFFPRKLLQNIGKSCLCYAESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLAFIRHVLFPLKSEFVILRDEKWGGNKTYTAYLDLEKDFADEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLSSAAYPDPSKQKPAVKGPAKNSEPEEVIPSRLDIRVGKVISVDKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASVEGVNRKVEPLDPPAGSAPGERVFVKGYEKGQPDEELKPKKKVFEKLQADFKISDEYIAQWKQTNFMTKLGSVSCKSLKGGNIS", "length": 547, "header": "tr|A0AAA9SNV2-1|F1MHM5_BOVIN Computationally mapped isoform of Tyrosine--tRNA ligase OS=Bos taurus OX=9913 GN=YARS1 PE=3 SV=1 CANONICAL=F1MHM5-1" }, "locus": { "chromosome": "2", "start_pos": 120880531, "end_pos": 120849244, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117546.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117546.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087041.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087041.1" } ] } }, { "isoform_ac": "A0AAA9SSB5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSB5/entry", "sequence": { "sequence": "MGDSLSPEEKLSLITRNLQVTILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLRFIKGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPALGYSKRIHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLAFIRHVLFPLKSEFVILRDEKWGGNKTYTAYLDLEKDFADEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLSSAAYPDPSKQKPAVKGPAKNSEPEEVIPSRLDIRVGKVISVDKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASVEGVNRKVEPLDPPAGSAPGERVFVKGYEKGQPDEELKPKKKVFEKLQADFKISDEYIAQWKQTNFMTKLGSVSCKSLKGGNIS", "length": 479, "header": "tr|A0AAA9SSB5-1|F1MHM5_BOVIN Computationally mapped isoform of Tyrosine--tRNA ligase OS=Bos taurus OX=9913 GN=YARS1 PE=3 SV=1 CANONICAL=F1MHM5-1" }, "locus": { "chromosome": "2", "start_pos": 120880531, "end_pos": 120849244, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105535.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105535.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085909.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085909.1" } ] } }, { "isoform_ac": "F1MHM5-1", "url": "https://www.uniprot.org/uniprotkb/F1MHM5/entry", "sequence": { "sequence": "MGDSLSPEEKLSLITRNLQEVLGEEKLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLRFIKGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPALGYSKRIHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLAFIRHVLFPLKSEFVILRDEKWGGNKTYTAYLDLEKDFADEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLSSAAYPDPSKQKPAVKGPAKNSEPEEVIPSRLDIRVGKVISVDKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASVEGVNRKVEPLDPPAGSAPGERVFVKGYEKGQPDEELKPKKKVFEKLQADFKISDEYIAQWKQTNFMTKLGSVSCKSLKGGNIS", "length": 528, "header": "tr|F1MHM5-1|F1MHM5_BOVIN Isoform 1 of Tyrosine--tRNA ligase OS=Bos taurus OX=9913 GN=YARS1 PE=3 SV=1 CANONICAL=F1MHM5-1" }, "locus": { "chromosome": "2", "start_pos": 120880531, "end_pos": 120849244, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024051.5", "url": "https://www.ensembl.org/id/ENSBTAT00000024051.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024051.3", "url": "https://www.ensembl.org/id/ENSBTAP00000024051.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LU27-1", "protein_name": "Tyrosine--tRNA ligase", "gene_name": "Yars1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQPEGTGVTVPGTRRRRRARKGRGCRLSAGSGESGAMGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTVYLELEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPPKQKPTAKGPAKNSEPEEIIPSRLDIRVGKIVSVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVDSQGMLLCASIEGVSRQVEPLDPPEGSAPGERVFVKGYEKGQPDEELKPKKKVFEKLQADFRISEECIAQWKQTNFMTKLGCISCKSLKGGNIS", "length": 564 }, "evidence": [ { "id": "F1MHM5", "url": "https://omabrowser.org/oma/group/F1MHM5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1NJU7-1", "protein_name": "Tyrosine--tRNA ligase", "gene_name": "YARS", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQPGHAAAAMETASGPQEKYQLITRNLQEVLGEDKLMAILKEREVKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTRYYEHVIKAMLESIGVPLEKLKFIRGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPSLGYAKRIHLMNPMVPGLTGSKMSSSEEDSKIDLLDRKEDVKKKLKKAFCEPGNIENNGVLSFIKHVLFPLKSEFVILREEKWGGNKTYTAYETLEKDFAEQVVHPGDLKNSVEVALNKLLDPIREKFNSPELKKLTNAAYPNPSKAKPAEKGTKNSEPETIVPSRLDIRVGKVVSVEKHPDADSLYVEKIDVGEPEPRTVVSGLVQFVPKEQLQDRLVVLLCNLKPQKMRGVESQGMVLCASSVGEPRQVEPLDPPAECCAGERVYVEGYEDGEPDDELKPKKKVFEKLQADFRISEDCIAQWKERNFLTKLGSISCKSLKGGSIS", "length": 536 }, "evidence": [ { "id": "F1MHM5", "url": "https://omabrowser.org/oma/group/F1MHM5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3L804-1", "protein_name": "Tyrosine--tRNA ligase", "gene_name": "YARS1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGDALSPEEKLHLITRNLQEVLGEEKLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVDNNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYSDLEKDFADEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLSSAAYPDPSKQKPVAKGPAKNSEPEEVIPSRLDIRVGRVISVDKHPDADSLYVEKVDVGEAEPRTVVSGLVQFVPKEDLQDRLVVVLCNLKPQKMRGIESQGMLLCASVEGVSRKVEPLDPPAGSAPGERVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS", "length": 528 }, "evidence": [ { "id": "F1MHM5", "url": "https://omabrowser.org/oma/group/F1MHM5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P36421-1", "protein_name": "Tyrosine--tRNA ligase, cytoplasmic", "gene_name": "TYS1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSSAATVDPNEAFGLITKNLQEVLNPQIIKDVLEVQKRHLKLYWGTAPTGRPHCGYFVPMTKLADFLKAGCEVTVLLADLHAFLDNMKAPLEVVNYRAKYYELTIKAILRSINVPIEKLKFVVGSSYQLTPDYTMDIFRLSNIVSQNDAKRAGADVVKQVANPLLSGLIYPLMQALDEQFLDVDCQFGGVDQRKIFVLAEENLPSLGYKKRAHLMNPMVPGLAQGGKMSASDPNSKIDLLEEPKQVKKKINSAFCSPGNVEENGLLSFVQYVIAPIQELKFGTNHFEFFIDRPEKFGGPITYKSFEEMKLAFKEEKLSPPDLKIGVADAINELLEPIRQEFANNKEFQEASEKGYPVATPQKSKKAKKPKNKGTKYPGATKTNEIATKLEETKL", "length": 394 }, "evidence": [ { "id": "F1MHM5", "url": "https://omabrowser.org/oma/group/F1MHM5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P54577-1", "protein_name": "Tyrosine--tRNA ligase, cytoplasmic", "gene_name": "YARS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS", "length": 528 }, "evidence": [ { "id": "F1MHM5", "url": "https://omabrowser.org/oma/group/F1MHM5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q4KM49-1", "protein_name": "Tyrosine--tRNA ligase, cytoplasmic", "gene_name": "Yars1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLKFTKGTDYQLSKEYTLDVYRLSSLVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPTLGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFVKHVLFPLKSEFVILRDEKWGGNKTYTIYQELEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPTAKGPAKSSEPEEIIPSRLDIRVGKILSVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVDSQGMLLCASVEGVSRQVEPLDPPAGSAPGERVFVQGYEKGQPDEELKPKKKVFEKLQADFKISDDCVAQWKQTNFMTKLGFVSCKSLKGGNIS", "length": 528 }, "evidence": [ { "id": "F1MHM5", "url": "https://omabrowser.org/oma/group/F1MHM5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8S9J2-1", "protein_name": "Tyrosine--tRNA ligase 1, cytoplasmic", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MADQSSEIVNALSSEMEAVSVSSTQASSSSDGFQMSEEVEKRYKIVRSIGEECIQEEELKNLLAKKAAPICYDGFEPSGRMHIAQGVMKVINVNKMTSAGCRVKIWIADWFAQLNNKMGGDLKKIRVVGEYFQEIWKAAGMDNDKVEFLWSSEEINSKADKYWPLVMDIARKNKLPRILRCVQIMGRSETDELSAAQILYPCMQCADIFFLEADICQLGMDQRKVNVLAREYCDDIKRKNKPIILSHHMLPGLQQGQEKMSKSDPLSAIFMEDEEAEVNVKIKKAYCPPKVVKGNPCLEYIKYIILPWFDEFTVERNEEYGGNKTYKSFEDIAADYESGELHPGDLKKGLMNALNKILQPVRDHFKTDARAKNLLKQIKAYRVTR", "length": 385 }, "evidence": [ { "id": "F1MHM5", "url": "https://omabrowser.org/oma/group/F1MHM5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q91WQ3-1", "protein_name": "Tyrosine--tRNA ligase, cytoplasmic", "gene_name": "Yars1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTVYLELEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPPAKGPAKNSEPEEVIPSRLDIRVGKILSVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVDSQGMLLCASVEGVSRQVEPLDPPAGSAPGERVFVQGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGFVSCKSLKGGNIS", "length": 528 }, "evidence": [ { "id": "F1MHM5", "url": "https://omabrowser.org/oma/group/F1MHM5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VV60-1", "protein_name": "Tyrosine--tRNA ligase", "gene_name": "TyrRS", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVGITPAEKKALITRNLQETLGDDKLTKILAERDLKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWSLLELRTKYYEQVIKAMLSSIGVPLEKLKFVKGSDYQLSKEYTLDVYKLSSVVTQHDAKKAGAEVVKQVEYPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFSEKYLPQLGYEKRIHFMNPMVPGLAGGKMSSSEEDSKIDLLDSPANVKKKLKKAFCEPGNIADNGLLSFVKHVLFSLFKEGEGFEVNREAEHGGDVTFLKYEDLEKYYAEDKLHPGDLKATVEKYINRLLDPIRKAFENPELQKLSAAAYPPPAKVKAGAAPAAGADEDAPHRLDIRVGKVVEVARHPDADTLYVLKIDLAEAQPRTIISGLVKFVTEEELNQRLVAVLCNLKPSKMRGILSEGMVLCTSNADHTVVEPIVLPATATAGSRLSFEGFSGTPDEQLNPKKKVWEKLSADFKTNSDGLAVWKDNFLLTPEGEKLSSKLANCSIK", "length": 525 }, "evidence": [ { "id": "F1MHM5", "url": "https://omabrowser.org/oma/group/F1MHM5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MHM5", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" } ], "pmid": "" }, { "name": "tRNA binding", "id": "GO:0000049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "evidence": [ { "database": "UniProtKB", "id": "F1MHM5", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" } ], "pmid": "" }, { "name": "tyrosine-tRNA ligase activity", "id": "GO:0004831", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004831", "evidence": [ { "database": "UniProtKB", "id": "F1MHM5", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MHM5", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MHM5", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MHM5", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "F1MHM5", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "response to stress", "id": "GO:0006950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006950", "evidence": [ { "database": "UniProtKB", "id": "F1MHM5", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" } ], "pmid": "" }, { "name": "tyrosyl-tRNA aminoacylation", "id": "GO:0006437", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006437", "evidence": [ { "database": "UniProtKB", "id": "F1MHM5", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" } ], "pmid": "" }, { "name": "response to starvation", "id": "GO:0042594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042594", "evidence": [ { "database": "UniProtKB", "id": "F1MHM5", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" }, { "start_pos": 526, "end_pos": 528, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10220", "name": "", "equation": "tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHM5-1", "Q29465-1" ], "evidence": [ { "id": "10220", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10220" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MHM5", "gene_name": "YARS1", "activity": [ { "ec_number": "6.1.1.1", "activity": "tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+).", "evidence": [ { "id": "F1MHM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" } ] }, { "ec_number": "6.1.1.1", "activity": "", "evidence": [ { "id": "F1MHM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" } ] } ] }, { "uniprot_ac": "Q29465", "gene_name": "YARS1", "activity": [ { "ec_number": "6.1.1.1", "activity": "tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+).", "evidence": [ { "id": "Q29465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29465" } ] }, { "ec_number": "6.1.1.1", "activity": "", "evidence": [ { "id": "Q29465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29465" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MHM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHM5" }, { "id": "PS50886", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50886" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TRNA-binding", "eco_id": "ECO_0000259", "start_pos": 364, "end_pos": 468, "start_aa": "Ile", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.1.1.1", "ec_name": "tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+).", "evidence": [ { "id": "6.1.1.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.1" }, { "id": "6.1.1.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.1.1.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 286, "end_pos": 288 }, { "start_pos": 526, "end_pos": 528 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MI38-1", "uniprot_ac": "F1MI38", "uniprot_id": "F1MI38_BOVIN", "mass": { "chemical_mass": 64547.0, "monoisotopic_mass": 64547.0 }, "refseq": {}, "gene_names": [ { "name": "ICAM1", "type": "recommended", "evidence": [ { "id": "F1MI38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI38" } ] } ], "protein_names": [ { "name": "Intercellular adhesion molecule 1", "type": "recommended", "evidence": [ { "id": "F1MI38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI38/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RU48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU48#function" }, { "database": "UniProtKB", "id": "ARBA00094499", "url": "https://www.uniprot.org/uniprotkb/ARBA00094499#function" }, { "database": "UniProtKB", "id": "F1MI38", "url": "https://www.uniprot.org/uniprotkb/F1MI38#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MI38", "url": "https://www.uniprot.org/uniprotkb/F1MI38" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ICAM1", "url": "https://www.uniprot.org/uniprotkb/F1MI38", "locus": { "chromosome": "7", "start_pos": 14824410, "end_pos": 14813530, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010303", "url": "https://www.ensembl.org/id/ENSBTAG00000010303" } ] } } ], "crossref": [ { "id": "F1MI38", "url": "https://alphafold.ebi.ac.uk/entry/F1MI38", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010303", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010303", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20996", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20996", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003988", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003988", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013768", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013768", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048679", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048679", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NLTVYWF", "url": "https://omabrowser.org/oma/group/NLTVYWF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MI38", "url": "https://www.orthodb.org/?gene=F1MI38", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13771", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13771", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13771:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13771:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03921", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03921", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21146", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21146", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RU48", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RU48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI38", "url": "https://www.uniprot.org/uniprotkb/F1MI38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI38-1", "url": "https://www.uniprot.org/uniprotkb/F1MI38-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGPLFRRGKQEVSGKHRPLGPPRPAQRYKRTREALGATVLAARLRPSWSAPPPPAMALGAAPAAQLALLALLGTLLPGPGGAGISIHPSKAIIPRGDSLTVNCSNSCDQKSTFGLETVLIKEEVGRGDNWKVFQLRDVQEDIELFCYSNCHKEQTIASMNLTVYWFPEHVELAPLPLWQPVGEELNLSCLVSGGAPRAHLSVVLLRGEEELARQPVGKGEPAKVMFTVQSRREDHGTNFSCRWELDLRSQGLELFQNTSAPRKLQTYVLPSIDPHLEVPPIVEVGSRWPVNCTLDGLFPASDAKVYLVLGDQKLESNITYDGDSVLAKAWMEENEEGTHSLKCSVSLGEVSRRTQENVTVYSFPLPTLTLSPPEVSEWTTVTVECVARDGAVVKLNGTSAVPPGPRAQLKLNASASDHRSNFSCSAALEIAGQVVHKHQTLELHVLYGPRLDQRDCPGNWTWQEGSEQTLKCEAQGNPIPKLNCSRKGDGASLPIGDLRPVRREVAGTYLCRATSARGRVTREVVLNVLHGQNILDIVIPVVAVTLILGALGTAGYVYNYQRKIQKYELQKARKAQEEAALKLNAQSTPP", "length": 591, "header": "tr|F1MI38-1|F1MI38_BOVIN Isoform 1 of Intercellular adhesion molecule 1 OS=Bos taurus OX=9913 GN=ICAM1 PE=3 SV=2 CANONICAL=F1MI38-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RU48-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RU48/entry", "sequence": { "sequence": "LLLKSSPSPQLSCLTTPLLIPGPGGAGISIHPSKAIIPRGDSLTVNCSNSCDQKSTFGLETVLIKEEVGRGDNWKVFQLRDVQEDIELFCYSNCHKEQTIASMNLTVYWFPEHVELAPLPLWQPVGEELNLSCLVSGGAPRAHLSVVLLRGEEELARQPVGKGEPAKVMFTVQSRREDHGTNFSCRWELDLRSQGLELFQNTSAPRKLQTYVLPSIDPHLEVPPIVEVGSRWPVNCTLDGLFPASDAKVYLVLGDQKLESNITYDGDSVLAKAWMEENEEGTHSLKCSVSLGEVSRRTQENVTVYSFPLPTLTLSPPEVSEWTTVTVECVARDGAVVKLNGTSAVPPGPRAQLKLNASASDHRSNFSCSAALEIAGQVVHKHQTLELHVLYGPRLDQRDCPGNWTWQEGSEQTLKCEAQGNPIPKLNCSRKGDGASLPIGDLRPVRREVAGTYLCRATSARGRVTREVVLNVLHGQNILDIVIPVVAVTLILGALGTAGYVYNYQRKIQKYELQKARKAQEEAALKLNAQSTPP", "length": 534, "header": "tr|A0AAA9RU48-1|F1MI38_BOVIN Computationally mapped isoform of Intercellular adhesion molecule 1 OS=Bos taurus OX=9913 GN=ICAM1 PE=3 SV=1 CANONICAL=F1MI38-1" }, "locus": { "chromosome": "7", "start_pos": 14823201, "end_pos": 14815507, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093824.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093824.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076658.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076658.1" } ] } }, { "isoform_ac": "F1MI38-1", "url": "https://www.uniprot.org/uniprotkb/F1MI38/entry", "sequence": { "sequence": "MPGPLFRRGKQEVSGKHRPLGPPRPAQRYKRTREALGATVLAARLRPSWSAPPPPAMALGAAPAAQLALLALLGTLLPGPGGAGISIHPSKAIIPRGDSLTVNCSNSCDQKSTFGLETVLIKEEVGRGDNWKVFQLRDVQEDIELFCYSNCHKEQTIASMNLTVYWFPEHVELAPLPLWQPVGEELNLSCLVSGGAPRAHLSVVLLRGEEELARQPVGKGEPAKVMFTVQSRREDHGTNFSCRWELDLRSQGLELFQNTSAPRKLQTYVLPSIDPHLEVPPIVEVGSRWPVNCTLDGLFPASDAKVYLVLGDQKLESNITYDGDSVLAKAWMEENEEGTHSLKCSVSLGEVSRRTQENVTVYSFPLPTLTLSPPEVSEWTTVTVECVARDGAVVKLNGTSAVPPGPRAQLKLNASASDHRSNFSCSAALEIAGQVVHKHQTLELHVLYGPRLDQRDCPGNWTWQEGSEQTLKCEAQGNPIPKLNCSRKGDGASLPIGDLRPVRREVAGTYLCRATSARGRVTREVVLNVLHGQNILDIVIPVVAVTLILGALGTAGYVYNYQRKIQKYELQKARKAQEEAALKLNAQSTPP", "length": 591, "header": "tr|F1MI38-1|F1MI38_BOVIN Isoform 1 of Intercellular adhesion molecule 1 OS=Bos taurus OX=9913 GN=ICAM1 PE=3 SV=2 CANONICAL=F1MI38-1" }, "locus": { "chromosome": "7", "start_pos": 14823201, "end_pos": 14813729, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013608.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013608.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013608.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013608.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1S3J9-1", "protein_name": "Intercellular adhesion molecule 1", "gene_name": "ICAM1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAPGATHPGQLALLALLLPLLGALLPGLGGAEISMWPLNTIIPKGGSMKVNCSVACDGNITSFGLETHWHKTEVDHRDKWKIFELSNVENDGTLLCHAVCQGNQTQVQGNLTVYWFPEYVKLANLSWQREGQHFNLSCQVSGGAPRTNLSAVLFRGEEELFRQSVGMEEPANVTFRMLASRKDHGANFSCRTELNLQPQGLELFWNSSAPLKLQTYVLPATHPHLATPELVEVGTPVSVNCSLDGLFPASEATVHLARGDHRPPLTITHNGDSLLAKTWINGTEKEQGTQYLVCEIMLADEKVVTKKNVTFYSFPPPNLTLSEPEVSEGTTVSIECQAHGEAVVTLNEVPAETPSQRAQLKLNVSAEDHGRSFSCSAALTVAGHVLYKNQTQVLSVLYGPRLDERDCPGNWTWPEGSHQTLTCQARGNPTPKLICRREGDGALLPTGDLGPVKREITGTYQCQATSSRGVATRVVVVNVIHNQNNMVIIIPVAAVAILGSVGVAAYIYNYQRKIQKYELQKAQENAAMKLSTPASPP", "length": 537 }, "evidence": [ { "id": "F1MI38", "url": "https://omabrowser.org/oma/group/F1MI38/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P05362-1", "protein_name": "Intercellular adhesion molecule 1", "gene_name": "ICAM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP", "length": 532 }, "evidence": [ { "id": "F1MI38", "url": "https://omabrowser.org/oma/group/F1MI38/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P13597-1", "protein_name": "Intercellular adhesion molecule 1", "gene_name": "Icam1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASTRAKPTLPLLLALVTVVIPGPGDAQVSIHPREAFLPQGGSVQVNCSSSCKEDLSLGLETQWLKDELESGPNWKLFELSEIGEDSSPLCFENCGTVQSSASATITVYSFPESVELRPLPAWQQVGKDLTLRCHVDGGAPRTQLSAVLLRGEEILSRQPVGGHPKDPKEITFTVLASRGDHGANFSCRTELDLRPQGLALFSNVSEARSLRTFDLPATIPKLDTPDLLEVGTQQKLFCSLEGLFPASEARIYLELGGQMPTQESTNSSDSVSATALVEVTEEFDRTLPLRCVLELADQILETQRTLTVYNFSAPVLTLSQLEVSEGSQVTVKCEAHSGSKVVLLSGVEPRPPTPQVQFTLNASSEDHKRSFFCSAALEVAGKFLFKNQTLELHVLYGPRLDETDCLGNWTWQEGSQQTLKCQAWGNPSPKMTCRRKADGALLPIGVVKSVKQEMNGTYVCHAFSSHGNVTRNVYLTVLYHSQNNWTIIILVPVLLVIVGLVMAASYVYNRQRKIRIYKLQKAQEEAIKLKGQAPPP", "length": 537 }, "evidence": [ { "id": "F1MI38", "url": "https://omabrowser.org/oma/group/F1MI38/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q00238-1", "protein_name": "Intercellular adhesion molecule 1", "gene_name": "Icam1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASTRARPMLPLLLVLVAVVIPGPVGAQVSIHPTEAFLPRGGSVQVNCSSSCEDENLGLGLETNWMKDELSSGHNWKLFKLSDIGEDSRPLCFENCGTTQSSASATITVYSFPERVELDPLPAWQQVGKNLILRCLVEGGAPRTQLSVVLLRGNETLSRQAVDGDPKEITFTVLASRGDHGANFSCFTELDLRPQGLSLFKNVSEVRQLRTFDLPTRVLKLDTPDLLEVGTQQKFLCSLEGLFPASEAQIYLEMGGQMLTLESTNSRDFVSATASVEVTEKLDRTLQLRCVLELADQTLEMEKTLRIYNFSAPILTLSQPEVSEGDQVTVKCEAHGGAQVVLLNSTSPRPPTSQGTSPRPPTSQIQFTLNASPEDHKRRFFCSAALEVDGKSLFKNQTLELHVLYGPHLDKKDCLGNWTWQEGSQQTLTCQPQGNPAPNLTCSRKADGVPLPIGMVKSVKREMNGTYKCRAFSSRGSITRDVHLTVLYHDQNTWVIIVGVLVLIIAGFVIVASIYTYYRQRKIRIYKLQKAQEEALKLKVQAPPP", "length": 545 }, "evidence": [ { "id": "F1MI38", "url": "https://omabrowser.org/oma/group/F1MI38/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "integrin binding", "id": "GO:0005178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005178", "evidence": [ { "database": "UniProtKB", "id": "F1MI38", "url": "https://www.uniprot.org/uniprotkb/F1MI38" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "F1MI38", "url": "https://www.uniprot.org/uniprotkb/F1MI38" } ], "pmid": "" }, { "name": "leukocyte cell-cell adhesion", "id": "GO:0007159", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007159", "evidence": [ { "database": "UniProtKB", "id": "F1MI38", "url": "https://www.uniprot.org/uniprotkb/F1MI38" } ], "pmid": "" }, { "name": "leukocyte migration", "id": "GO:0050900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050900", "evidence": [ { "database": "UniProtKB", "id": "F1MI38", "url": "https://www.uniprot.org/uniprotkb/F1MI38" } ], "pmid": "" }, { "name": "cellular response to oxygen-containing compound", "id": "GO:1901701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901701", "evidence": [ { "database": "UniProtKB", "id": "F1MI38", "url": "https://www.uniprot.org/uniprotkb/F1MI38" } ], "pmid": "" }, { "name": "immune effector process", "id": "GO:0002252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002252", "evidence": [ { "database": "UniProtKB", "id": "F1MI38", "url": "https://www.uniprot.org/uniprotkb/F1MI38" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1MI38", "url": "https://www.uniprot.org/uniprotkb/F1MI38" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MI38", "url": "https://www.uniprot.org/uniprotkb/F1MI38" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MI38", "url": "https://www.uniprot.org/uniprotkb/F1MI38" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" }, { "start_pos": 258, "end_pos": 260, "annotation": "n_glycosylation_sequon" }, { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 358, "end_pos": 360, "annotation": "n_glycosylation_sequon" }, { "start_pos": 397, "end_pos": 399, "annotation": "n_glycosylation_sequon" }, { "start_pos": 413, "end_pos": 415, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 460, "end_pos": 462, "annotation": "n_glycosylation_sequon" }, { "start_pos": 484, "end_pos": 486, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MI38-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 591, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MI38-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MI38" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MI38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI38" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": 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Required for auditory function. Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. 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"Protein Classification", "Other" ] }, { "id": "R-BTA-379397", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-379397", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001268972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268972", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17877", "url": "https://www.rhea-db.org/rhea/17877", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53088", "url": "https://www.rhea-db.org/rhea/53088", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53092", "url": "https://www.rhea-db.org/rhea/53092", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53096", "url": "https://www.rhea-db.org/rhea/53096", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53100", "url": "https://www.rhea-db.org/rhea/53100", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53104", "url": 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"MSPAIALAFLPLVVTLLVRYRHYFRLLVRTVLLRSLRDCLSGLRMEERAFSYVLTHALPGDPGHILTTLDHWSSHCEYLSHMGPAKGQILMRLVEEKAPASALELGTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAGFDEHTVELIVGRSEEVIPRLRTQYQLSRADLVLLAHRPRCYLRDLQLLEGHALLPAGATVLADHVLFPGAPRFLQYAKSCGRYRCRLHHTGLPDFPAIKDGIAQLTYAGPG", "length": 258, "header": "tr|F1MCR3-1|F1MCR3_BOVIN Isoform 1 of Catechol O-methyltransferase OS=Bos taurus OX=9913 GN=TOMT PE=3 SV=3 CANONICAL=F1MCR3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUP6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUP6/entry", "sequence": { "sequence": "MTGTRIQAQVGTMSPAIALAFLPLVVTLLVRYRHYFRLLVRTVLLRSLRDCLSGLRMEERAFSYVLTHALPGDPGHILTTLDHWSSHCEYLSHMGPAKGQILMRLVEEKAPASALELGTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAGFDEHTVELIVGRSEEVIPRLRTQYQLSRADLVLLAHRPRCYLRDLQLLEGHALLPAGATVLADHVLFPGAPRFLQYAKSCGRYRCRLHHTGLPDFPAIKDGIAQLTYAGPG", "length": 270, "header": "tr|A0AAA9RUP6-1|F1MCR3_BOVIN Computationally mapped isoform of Catechol O-methyltransferase OS=Bos taurus OX=9913 GN=TOMT PE=3 SV=1 CANONICAL=F1MCR3-1" }, "locus": { "chromosome": "15", "start_pos": 51741517, "end_pos": 51736237, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101796.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101796.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075907.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075907.1" } ] } }, { "isoform_ac": "F1MCR3-1", "url": "https://www.uniprot.org/uniprotkb/F1MCR3/entry", "sequence": { "sequence": "MSPAIALAFLPLVVTLLVRYRHYFRLLVRTVLLRSLRDCLSGLRMEERAFSYVLTHALPGDPGHILTTLDHWSSHCEYLSHMGPAKGQILMRLVEEKAPASALELGTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAGFDEHTVELIVGRSEEVIPRLRTQYQLSRADLVLLAHRPRCYLRDLQLLEGHALLPAGATVLADHVLFPGAPRFLQYAKSCGRYRCRLHHTGLPDFPAIKDGIAQLTYAGPG", "length": 258, "header": "tr|F1MCR3-1|F1MCR3_BOVIN Isoform 1 of Catechol O-methyltransferase OS=Bos taurus OX=9913 GN=TOMT PE=3 SV=3 CANONICAL=F1MCR3-1" }, "locus": { "chromosome": "15", "start_pos": 51741517, "end_pos": 51739209, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003905.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003905.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003905.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003905.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:517795", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517795", "resource": "KEGG Pathway" }, { "id": "R-BTA-379397", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-379397", "resource": "Reactome", "description": "Enzymatic degradation of dopamine by COMT" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A193KX02-1", "protein_name": "Transmembrane O-methyltransferase homolog", "gene_name": "tomt", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVSPAIALAFLPLLLTLIIRYRYYFVLLYRAVLTRWVRDCLSGISREERAFQYILTHATPGDSQSILDTFDTWCSKVEFISNIGPKKGKILDRLLQENCPITVLELGTHCGYSTVRMARSLPIGARIYSVEMDQRNAQVAEKIIRLAGFDDDMVELIQRPSDEVIPRLREDLGVERLDLVLMDHWKRCYLPDLHLLEDSGLIGQGSIILADNVIFPGAPNFLRYARRCGLYEVRVHRATLEYMRGIPDGMAELTYIGIK", "length": 259 }, "evidence": [ { "id": "F1MCR3", "url": "https://omabrowser.org/oma/group/F1MCR3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A1Y9I9-1", "protein_name": "Transmembrane O-methyltransferase homolog", "gene_name": "Tomt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSPAIALAFLPLVVTLLVRYRHHFRLLVRTVLLRGFRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSCCEYLSHMGPVKGQILMRLVEEKAPACVLELGTYCGYSTLLIARALPPGSRLLTVERDSRTAAVAEKVIRLAGFDEQMVELIAGSSEEVIPRLRAQHQLNRADLVLLAHRPRYYLRDLQLLEAHALLPHGATVLADHVLFPGAPRFLQYTKSCGRYRCRLHHTSLPDFPAIKDGIAQLTYTGPG", "length": 258 }, "evidence": [ { "id": "F1MCR3", "url": "https://omabrowser.org/oma/group/F1MCR3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B6CZ62-1", "protein_name": "Transmembrane O-methyltransferase homolog", "gene_name": "Tomt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSPAIALAFLPLVVTLLVRYRHHFRLLVRTVLLRSFRDCLSGLRIEERAFSYVITHALPGDPGHILTTLDHWSSCCEYLSHMGPIKGQILMRLVEEKAPACVLELGTHCGYSTLLIARALPPGSRLLTVERDSRTAAVAEKVIRLAGFDEQMVELIAGSSEEVIPRLRAQHQLNRADLVLLAHRPRYYLRDLQLLEAHALLPHGATVLADHVLFPGAPRFLQYTKSCGRYRCRLHHTSLPDFPAIKDGIAQLTYTGPG", "length": 258 }, "evidence": [ { "id": "F1MCR3", "url": "https://omabrowser.org/oma/group/F1MCR3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8WZ04-1", "protein_name": "Transmembrane O-methyltransferase", "gene_name": "TOMT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGTPWRKRKGIAGPGLPDLSCALVLQPRAQVGTMSPAIALAFLPLVVTLLVRYRHYFRLLVRTVLLRSLRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSRCEYLSHMGPVKGQILMRLVEEKAPACVLELGTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAGFDEHMVELIVGSSEDVIPCLRTQYQLSRADLVLLAHRPRCYLRDLQLLEAHALLPAGATVLADHVLFPGAPRFLQYAKSCGRYRCRLHHTGLPDFPAIKDGIAQLTYAGPG", "length": 291 }, "evidence": [ { "id": "F1MCR3", "url": "https://omabrowser.org/oma/group/F1MCR3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1MCR3", "url": "https://www.uniprot.org/uniprotkb/F1MCR3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MCR3", "url": "https://www.uniprot.org/uniprotkb/F1MCR3" } ], "pmid": "" }, { "name": "apical part of cell", "id": "GO:0045177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "evidence": [ { "database": "UniProtKB", "id": "F1MCR3", "url": "https://www.uniprot.org/uniprotkb/F1MCR3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "positive regulation of protein import", "id": "GO:1904591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904591", "evidence": [ { "database": "UniProtKB", "id": "F1MCR3", "url": "https://www.uniprot.org/uniprotkb/F1MCR3" } ], "pmid": "" }, { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "F1MCR3", "url": "https://www.uniprot.org/uniprotkb/F1MCR3" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "F1MCR3", "url": "https://www.uniprot.org/uniprotkb/F1MCR3" } ], "pmid": "" }, { "name": "auditory receptor cell development", "id": "GO:0060117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060117", "evidence": [ { "database": "UniProtKB", "id": "F1MCR3", "url": "https://www.uniprot.org/uniprotkb/F1MCR3" } ], "pmid": "" }, { "name": "catecholamine catabolic process", "id": "GO:0042424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042424", "evidence": [ { "database": "UniProtKB", "id": "F1MCR3", "url": "https://www.uniprot.org/uniprotkb/F1MCR3" } ], "pmid": "" }, { "name": "developmental process", "id": "GO:0032502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032502", "evidence": [ { "database": "UniProtKB", "id": "F1MCR3", "url": "https://www.uniprot.org/uniprotkb/F1MCR3" } ], "pmid": "" }, { "name": "dopamine metabolic process", "id": "GO:0042417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042417", "evidence": [ { "database": "UniProtKB", "id": "F1MCR3", "url": "https://www.uniprot.org/uniprotkb/F1MCR3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "catechol O-methyltransferase activity", "id": "GO:0016206", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016206", "evidence": [ { "database": "UniProtKB", "id": "F1MCR3", "url": "https://www.uniprot.org/uniprotkb/F1MCR3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17877", "name": "", "equation": "a catechol + S-adenosyl-L-methionine = a guaiacol + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MCR3-1", "A7MBI7-1" ], "evidence": [ { "id": "17877", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17877" } ] }, { "id": "53088", "name": "", "equation": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A7MBI7-1", "F1MCR3-1" ], "evidence": [ { "id": "53088", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53088" } ] }, { "id": "53092", "name": "", "equation": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A7MBI7-1", "F1MCR3-1" ], "evidence": [ { "id": "53092", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53092" } ] }, { "id": "53096", "name": "", "equation": "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 4-methoxy-17beta-estradiol + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A7MBI7-1", "F1MCR3-1" ], "evidence": [ { "id": "53096", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53096" } ] }, { "id": "53100", "name": "", "equation": "2-hydroxyestrone + S-adenosyl-L-methionine = 2-methoxyestrone + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A7MBI7-1", "F1MCR3-1" ], "evidence": [ { "id": "53100", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53100" } ] }, { "id": "53104", "name": "", "equation": "4-hydroxyestrone + S-adenosyl-L-methionine = 4-methoxyestrone + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A7MBI7-1", "F1MCR3-1" ], "evidence": [ { "id": "53104", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53104" } ] }, { "id": "53108", "name": "", "equation": "2-hydroxyestrone + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-estrone + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A7MBI7-1", "F1MCR3-1" ], "evidence": [ { "id": "53108", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53108" } ] }, { "id": "R-BTA-8955010", "name": "LRTOMT transfers Met to DA, forming 3MT", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MCR3-1" ], "evidence": [ { "id": "R-BTA-8955010", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8955010" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A7MBI7", "gene_name": "COMT", "activity": [ { "ec_number": "2.1.1.6", "activity": "a catechol + S-adenosyl-L-methionine = a guaiacol + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A7MBI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBI7" } ] }, { "ec_number": "2.1.1.6", "activity": "", "evidence": [ { "id": "A7MBI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBI7" } ] } ] }, { "uniprot_ac": "F1MCR3", "gene_name": "TOMT", "activity": [ { "ec_number": "2.1.1.6", "activity": "a catechol + S-adenosyl-L-methionine = a guaiacol + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "F1MCR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCR3" } ] }, { "ec_number": "2.1.1.6", "activity": "", "evidence": [ { "id": "F1MCR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCR3" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.6", "ec_name": "a catechol + S-adenosyl-L-methionine = a guaiacol + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "2.1.1.6", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.6" }, { "id": "2.1.1.6", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.6" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJ28-1", "uniprot_ac": "F1MJ28", "uniprot_id": "F1MJ28_BOVIN", "mass": { "chemical_mass": 97279.0, "monoisotopic_mass": 97279.0 }, "refseq": {}, "gene_names": [ { "name": "PYGM", "type": "recommended", "evidence": [ { "id": "F1MJ28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ28" } ] } ], "protein_names": [ { "name": "Alpha-1,4 glucan phosphorylase", "type": "recommended", "evidence": [ { "id": "F1MJ28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ28/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.1", "type": "synonym", "evidence": [ { "id": "F1MJ28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ28/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RVU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVU6#function" }, { "database": "UniProtKB", "id": "RU000587", "url": "https://www.uniprot.org/uniprotkb/RU000587#function" }, { "database": "UniProtKB", "id": "ARBA00037413", "url": "https://www.uniprot.org/uniprotkb/ARBA00037413#function" }, { "database": "UniProtKB", "id": "F1MJ28", "url": "https://www.uniprot.org/uniprotkb/F1MJ28#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJ28", "url": "https://www.uniprot.org/uniprotkb/F1MJ28" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PYGM", "url": "https://www.uniprot.org/uniprotkb/F1MJ28", "locus": { "chromosome": "29", "start_pos": 42985599, "end_pos": 42997435, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001032", "url": "https://www.ensembl.org/id/ENSBTAG00000001032" } ] } } ], "crossref": [ { "id": "F1MJ28", "url": "https://alphafold.ebi.ac.uk/entry/F1MJ28", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001032", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001032", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04300", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04300", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000811", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000811", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011833", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011833", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035090", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035090", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GIEPCRC", "url": "https://omabrowser.org/oma/group/GIEPCRC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MJ28", "url": "https://www.orthodb.org/?gene=F1MJ28", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11468", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11468", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11468:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11468:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00343", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00343", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-70221", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70221", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "41732", "url": "https://www.rhea-db.org/rhea/41732", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RVU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVU6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ28", "url": "https://www.uniprot.org/uniprotkb/F1MJ28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ28-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ28-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRPLTDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAYTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYIGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCLDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDQERLEWEKAWEVTVKTCAYTNHTVLPEALERWPVHLIETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVMCNPGLAEIIAERIGEEYIADLDQLRKLLSYVDDESFIRDVAKVKQENKLKFSAYLEKEYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFFVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVERLDQKGYNAQEYYDRIPELRHVIDQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPTRQRMPAPDEKI", "length": 842, "header": "tr|F1MJ28-1|F1MJ28_BOVIN Isoform 1 of Alpha-1,4 glucan phosphorylase OS=Bos taurus OX=9913 GN=PYGM PE=3 SV=2 CANONICAL=F1MJ28-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RVU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVU6/entry", "sequence": { "sequence": "MSRPLTDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAYTVRDHLVGRWIRTQQHYYEKDPKKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCLDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDQERLEWEKAWEVTVKTCAYTNHTVLPEALERWPVHLIETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVMCNPGLAEIIAERIGEEYIADLDQLRKLLSYVDDESFIRDVAKVKQENKLKFSAYLEKEYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFFVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVERLDQKGYNAQEYYDRIPELRHVIDQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPTRQRMPAPDEKI", "length": 754, "header": "tr|A0AAA9RVU6-1|F1MJ28_BOVIN Computationally mapped isoform of Alpha-1,4 glucan phosphorylase OS=Bos taurus OX=9913 GN=PYGM PE=3 SV=1 CANONICAL=F1MJ28-1" }, "locus": { "chromosome": "29", "start_pos": 42997366, "end_pos": 42985890, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096364.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096364.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076473.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076473.1" } ] } }, { "isoform_ac": "F1MJ28-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ28/entry", "sequence": { "sequence": "MSRPLTDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAYTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYIGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCLDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDQERLEWEKAWEVTVKTCAYTNHTVLPEALERWPVHLIETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVMCNPGLAEIIAERIGEEYIADLDQLRKLLSYVDDESFIRDVAKVKQENKLKFSAYLEKEYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFFVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVERLDQKGYNAQEYYDRIPELRHVIDQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPTRQRMPAPDEKI", "length": 842, "header": "tr|F1MJ28-1|F1MJ28_BOVIN Isoform 1 of Alpha-1,4 glucan phosphorylase OS=Bos taurus OX=9913 GN=PYGM PE=3 SV=2 CANONICAL=F1MJ28-1" }, "locus": { "chromosome": "29", "start_pos": 42997366, "end_pos": 42985890, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001373.6", "url": "https://www.ensembl.org/id/ENSBTAT00000001373.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001373.4", "url": "https://www.ensembl.org/id/ENSBTAP00000001373.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-70221", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70221", "resource": "Reactome", "description": "Glycogen breakdown (glycogenolysis)" } ], "orthologs": [ { "uniprot_canonical_ac": "P09812-1", "protein_name": "Glycogen phosphorylase, muscle form", "gene_name": "Pygm", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRPLSDQDKRKQISVRGLAGVENVSDLKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVDRWIRTQQHYYAKDPKRIYYLSLELYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPPYFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDKFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELIRILVDLERLDWDKAWDVTVKTCAYTNHTVLPEALERWPVHLMETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEEYISDLDQLRKLLSYLDDQAFIRDVAKVKQENKLKFSAYLETEYKVHINPNSLFDVQVKRIHEYKRQLLNCLHIITLYNRIKREPNRFMVPRTIMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPAVGDRFRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEDNFFIFGMRVEDVERLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMVMHHDRFKVFADYEEYIKCQDKVSELYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGLEPSRQRLPAPDEKI", "length": 842 }, "evidence": [ { "id": "F1MJ28", "url": "https://omabrowser.org/oma/group/F1MJ28/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P11217-1", "protein_name": "Glycogen phosphorylase, muscle form", "gene_name": "PYGM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERMDWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFVPRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDKLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEDYIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEAI", "length": 842 }, "evidence": [ { "id": "F1MJ28", "url": "https://omabrowser.org/oma/group/F1MJ28/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P34114-1", "protein_name": "Glycogen phosphorylase 2", "gene_name": "glpD", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEEKRSTNSPGFDKPKLNRSGSITSATSHPPRSNSNPKLVAKHQQQLYEESKNKRNQEQQNQQPQQQQQKQTSNQSEDPATQLSSLKFESDKEKEQALLWAFLASYLPEDKGSLQKEFVKHVEYTLAQTKSECTDFSSFQALSYCTRDRLIERWKDTKLFFKQKNVKQVNYMSLEFLLGRSLQNSLSALGLVGKYSDALMDLGFKLEDLYDEERDAGLGNGGLGRLAACFMDSLATCNFPGYGYGLRYKFGMFYQTLVDGEQVELPDYWLNYGSPWEIERLDVSYPINFYGKVSEVEDENGKKVMKWDQGEQMLAVAYDYPIPGFKTYNTVAIRLWSSKPSDEFNLDSFNRGDYLGAIEEKEKSENITNVLYPNDNTMQGKELRLKQQYLFVSATIQDIISQFKETGKPFSEFHNFHAIQLNDTHPTLGIPELMRILIDEEKKSWDEAWDITTKTFSYTNHTVLPEALEKWSVSMVENVLPRHIMIIYEINERFLKLVDQKWPGDMSKRRALSIIDESDGKFIRMAFLAIVGSHTINGVAYLHSELVKHDVFPLFYEIWPNKFQNKTNGVTPRRWIQQSNPQLAELITRSLNSDRWLVNLDIIKDLVHLADNSSFQKEWMEIKRNNKIRLAKYIEKRCDIQVNVDVLFDVQVKRFHEYKRQLLNVLSVINRYLDIKEGKKVAPRVVIFGGKAAPGYYMAKLIIKLINSVADVVNNDPKVGDLLKVVFIPNYCVSNAEIIIPASDISQHISTAGTEASGTSNMKFSMNGGLIIGTLDGANIEIRDAIGHENMYIFGARSEEVNKVKKIIHDGKFTPDTRWARVLTAIKEDTFGPHEQFQDIINSVSGGNDHYILSYDFGSYLDIQNSIDQDFKDRAKWAKKSIMASVCCGKFSSDRTIKEYAQQIWGIEEWKRPGPVPVSNEEARSLLVPPPSGSPNDINAISIERLSPLTFVKQTSASPLSVISGGDKTNNTLKPKQTTKGFNIGGQPGNPTN", "length": 993 }, "evidence": [ { "id": "F1MJ28", "url": "https://omabrowser.org/oma/group/F1MJ28/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9WUB3-1", "protein_name": "Glycogen phosphorylase, muscle form", "gene_name": "Pygm", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRPLSDQDKRKQISVRGLAGVENVSELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGSRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERLDWDKAWDVTVKTCAYTNHTVLPEALERWPVHLMETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERIGEDYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFSAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHIITLYNRIKREPNRFMVPRTIMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVERLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYIKCQDKVSELYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEKI", "length": 842 }, "evidence": [ { "id": "F1MJ28", "url": "https://omabrowser.org/oma/group/F1MJ28/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "pyridoxal phosphate binding", "id": "GO:0030170", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170", "evidence": [ { "database": "UniProtKB", "id": "F1MJ28", "url": "https://www.uniprot.org/uniprotkb/F1MJ28" } ], "pmid": "" }, { "name": "glycogen phosphorylase activity", "id": "GO:0008184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008184", "evidence": [ { "database": "UniProtKB", "id": "F1MJ28", "url": "https://www.uniprot.org/uniprotkb/F1MJ28" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "glycogen metabolic process", "id": "GO:0005977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005977", "evidence": [ { "database": "UniProtKB", "id": "F1MJ28", "url": "https://www.uniprot.org/uniprotkb/F1MJ28" } ], "pmid": "" }, { "name": "glycogen catabolic process", "id": "GO:0005980", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005980", "evidence": [ { "database": "UniProtKB", "id": "F1MJ28", "url": "https://www.uniprot.org/uniprotkb/F1MJ28" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MJ28", "url": "https://www.uniprot.org/uniprotkb/F1MJ28" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 24, "end_pos": 26, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" }, { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" }, { "start_pos": 482, "end_pos": 484, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "41732", "name": "", "equation": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJ28-1", "Q0VCM4-1", "P79334-1", "F1MU24-1", "Q3B7M9-1" ], "evidence": [ { "id": "41732", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41732" } ] }, { "id": "R-BTA-453338", "name": "PYGM b dimer:AMP complex => PYGM dimer, b form + 2 AMP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJ28-1" ], "evidence": [ { "id": "R-BTA-453338", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-453338" } ] }, { "id": "R-BTA-453342", "name": "PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJ28-1" ], "evidence": [ { "id": "R-BTA-453342", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-453342" } ] }, { "id": "R-BTA-71541", "name": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJ28-1" ], "evidence": [ { "id": "R-BTA-71541", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71541" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MJ28", "gene_name": "PYGM", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "F1MJ28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ28" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "F1MJ28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ28" } ] } ] }, { "uniprot_ac": "F1MU24", "gene_name": "PYGB", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "F1MU24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU24" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "F1MU24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU24" } ] } ] }, { "uniprot_ac": "P79334", "gene_name": "PYGM", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "P79334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79334" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "P79334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79334" } ] } ] }, { "uniprot_ac": "Q0VCM4", "gene_name": "PYGL", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "Q0VCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCM4" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "Q0VCM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCM4" } ] } ] }, { "uniprot_ac": "Q3B7M9", "gene_name": "PYGB", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "Q3B7M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M9" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "Q3B7M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3B7M9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJ28-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 842, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJ28-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJ28" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.4.1.1", "ec_name": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "2.4.1.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1" }, { "id": "2.4.1.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.1.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 24, "end_pos": 26 }, { "start_pos": 275, "end_pos": 277 }, { "start_pos": 339, "end_pos": 341 }, { "start_pos": 377, "end_pos": 379 }, { "start_pos": 482, "end_pos": 484 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MBG2-1", "uniprot_ac": "F1MBG2", "uniprot_id": "F1MBG2_BOVIN", "mass": { "chemical_mass": 45128.0, "monoisotopic_mass": 45128.0 }, "refseq": { "ac": "XP_024836422", "name": "rhomboid-related protein 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836422" }, "gene_names": [ { "name": "RHBDL3", "type": "recommended", "evidence": [ { "id": "F1MBG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBG2" } ] }, { "name": "RHBDL3", "type": "synonym", "evidence": [ { "id": "XP_024836422", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836422" } ] } ], "protein_names": [ { "name": "Rhomboid-related protein 3", "type": "recommended", "evidence": [ { "id": "F1MBG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBG2/entry#names_and_taxonomy" } ] }, { "name": "3.4.21.105", "type": "synonym", "evidence": [ { "id": "F1MBG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBG2/entry#names_and_taxonomy" } ] }, { "name": "rhomboid-related protein 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024836422", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836422" } ] } ], "function": [ { "annotation": "May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.", "evidence": [ { "database": "UniProtKB", "id": "F1MBG2", "url": "https://www.uniprot.org/uniprotkb/F1MBG2#function" }, { "database": "UniProtKB", "id": "PIRNR037470", "url": "https://www.uniprot.org/uniprotkb/PIRNR037470#function" }, { "database": "UniProtKB", "id": "ARBA00057065", "url": "https://www.uniprot.org/uniprotkb/ARBA00057065#function" }, { "database": "UniProtKB", "id": "A0AAA9RYL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYL5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MBG2", "url": "https://www.uniprot.org/uniprotkb/F1MBG2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RHBDL3", "url": "https://www.uniprot.org/uniprotkb/F1MBG2", "locus": { "chromosome": "19", "start_pos": 17823299, "end_pos": 17876082, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020992", "url": "https://www.ensembl.org/id/ENSBTAG00000020992" } ] } } ], "crossref": [ { "id": "F1MBG2", "url": "https://alphafold.ebi.ac.uk/entry/F1MBG2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020992", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020992", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535623", "url": "https://www.ncbi.nlm.nih.gov/gene/535623", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022764", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022764", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535623", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535623", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MAPEDHW", "url": "https://omabrowser.org/oma/group/MAPEDHW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MBG2", "url": "https://www.orthodb.org/?gene=F1MBG2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45840", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45840", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45840:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45840:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01694", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01694", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024836422", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836422", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RYL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBG2", "url": "https://www.uniprot.org/uniprotkb/F1MBG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBG2-1", "url": "https://www.uniprot.org/uniprotkb/F1MBG2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGEHPSPGPAVAACAEAERIEELEPEAEERPPAEDHWKVLFDQFDPGNTGFISTGKFRSLLDSHSSKLDPHKREVLLALADSHANGQICYQDFVNLMSNKRSNSFRQAILQGNRRLCSKALLEEKGLNLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQFVLQVTHPRYLKNPLVYHPQLRAQAWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMSMEFGRAVWLRFHPSAYPPCPHPSFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVAMYTVFVLFAVFWNIFAYTLLDLKLPPPP", "length": 402, "header": "tr|F1MBG2-1|F1MBG2_BOVIN Isoform 1 of Rhomboid-related protein 3 OS=Bos taurus OX=9913 GN=RHBDL3 PE=3 SV=2 CANONICAL=F1MBG2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYL5/entry", "sequence": { "sequence": "MGEHPSPGPAVAACAEAERIEELEPEAEERPPAEDHWKVLFDQFDPGNTGFISTGKFRSLLDSHSSKLDPHKREVLLALADSHANGQICYQDFVNLMSNKRSNSFRQAILQGNRRLCSKALLEEKGLNLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQFVLQVTHPRYLKNPLVYHPQLRAQAWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICRPARERAGRCLGTRGGRRSEHGVWTGRVAALPPVSLPSLPSPELRGALGWRGCGHHPGCGGPEELRAEAARPVAVVDFCGHVHRLRAVRCLLEHLCLHPAGLEAAATPLKA", "length": 423, "header": "tr|A0AAA9RYL5-1|F1MBG2_BOVIN Computationally mapped isoform of Rhomboid-related protein 3 OS=Bos taurus OX=9913 GN=RHBDL3 PE=3 SV=1 CANONICAL=F1MBG2-1" }, "locus": { "chromosome": "19", "start_pos": 17875792, "end_pos": 17824303, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090270.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090270.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078666.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078666.1" } ] } }, { "isoform_ac": "F1MBG2-1", "url": "https://www.uniprot.org/uniprotkb/F1MBG2/entry", "sequence": { "sequence": "MGEHPSPGPAVAACAEAERIEELEPEAEERPPAEDHWKVLFDQFDPGNTGFISTGKFRSLLDSHSSKLDPHKREVLLALADSHANGQICYQDFVNLMSNKRSNSFRQAILQGNRRLCSKALLEEKGLNLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQFVLQVTHPRYLKNPLVYHPQLRAQAWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMSMEFGRAVWLRFHPSAYPPCPHPSFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVAMYTVFVLFAVFWNIFAYTLLDLKLPPPP", "length": 402, "header": "tr|F1MBG2-1|F1MBG2_BOVIN Isoform 1 of Rhomboid-related protein 3 OS=Bos taurus OX=9913 GN=RHBDL3 PE=3 SV=2 CANONICAL=F1MBG2-1" }, "locus": { "chromosome": "19", "start_pos": 17875792, "end_pos": 17824311, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027954.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027954.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027954.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027954.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:535623", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535623", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AJE5-1", "protein_name": "Rhomboid-related protein 3", "gene_name": "RHBDL3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGDRLPEPHASSSPAVAAGSEAEEIEVLDSEDVLPMAAEDHWKALFDQFDPDNTGYISTEKFRSLLQRHGSELDPHKLEVLLALADSNSEGRICYQDFVNLMSNKRSNSFRQAILQGNRRLCSKALLEETGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITITIVEVAFFLYNGVVLDRFVLQVTHPLYLKNALLYHPQLRAQAWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGAARISFVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMSFEFGRAVWLRFHPSAYPPCPHPSFMAHLGGVMVGITLGVIILRNYEQRLQDQTLWWIFLSIYLIFVLFAIFWNIFAYSLLDLKLPPPP", "length": 407 }, "evidence": [ { "id": "F1MBG2", "url": "https://omabrowser.org/oma/group/F1MBG2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4AAW6-1", "protein_name": "Rhomboid-related protein 3", "gene_name": "Rhbdl3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGEHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDHWKVLFEKFDPGSTGYISTGKFRSLLESHSSKLDPHKKEVLLALADSHADGQICYQDFVNLMSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITITLLEARTRVALFLYNGVLLDQFVLQVTHPRYLKNSLVYHPQLRAQAWRYVTYIFMHAGVEQLGLNVALQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMSMEFGRAVWLRFHPSAYPPCPHPSFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVTMYTIFVLFAVFWNIFAYTLLDLKLPPPP", "length": 408 }, "evidence": [ { "id": "F1MBG2", "url": "https://omabrowser.org/oma/group/F1MBG2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P58872-1", "protein_name": "Rhomboid-related protein 3", "gene_name": "RHBDL3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGEHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDHWKVLFDQFDPGNTGYISTGKFRSLLESHSSKLDPHKREVLLALADSHADGQIGYQDFVSLMSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQFVLQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMSMEFGRAVWLRFHPSAYPPCPHPSFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVAMYTVFVLFAVFWNIFAYTLLDLKLPPPP", "length": 404 }, "evidence": [ { "id": "F1MBG2", "url": "https://omabrowser.org/oma/group/F1MBG2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P58873-1", "protein_name": "Rhomboid-related protein 3", "gene_name": "Rhbdl3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGEHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDHWKVLFEKFDPGSTGYISTGKFRSLLESHSSKLDPHKKEVLLALADSHADGQICYQDFVNLMSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITITLLEVALFLYNGVLLDQFVLQVTHPRYLKNSLVYHPQLRAQAWRYVTYIFMHAGVEQLGLNVALQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMSMEFGRAVWLRFHPSAYPPCPHPSFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVTMYTIFVLFAVFWNIFAYTLLDLKLPPAP", "length": 404 }, "evidence": [ { "id": "F1MBG2", "url": "https://omabrowser.org/oma/group/F1MBG2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W0E9-1", "protein_name": "3.4.21.-", "gene_name": "stet", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MWPGSERGSSRALEIPTSQQNAGGSSQQETLADIEHISTIAGSLASIGSLSHTQMRYQCTNDAGYDTEHTSLNSDFDEAELRRELLRDKWKLLFDMFDPEGFGEISVEEFLEALKSPEFLSQVPMNKRELLLERAKKAKLPTGPGYVTFQDFVNVMSGKRTRSFKCAVHHRDREVCSENDFQLVLNEPPLFRKMVHAVAMEILPEERDRKYYADRYTCCPPPFFIILVTLVELGFFVYHSVVTGEAAPRGPIPSDSMFIYRPDKRHEIWRFLFYMVLHAGWLHLGFNVAVQLVFGLPLEMVHGSTRIACIYFSGVLAGSLGTSIFDPDVFLVGASGGVYALLAAHLANVLLNYHQMRYGVIKLLHILVFVSFDFGFAIYARYAGDELQLGSSSEFLAIDQAETAGAVSYVAHLAGAIAGLTIGLLVLKSFEQKLHEQLLWWIALGTYLALVVFAIAFNIMNGFAMFNIRVEKIRVTETIFNDFQV", "length": 485 }, "evidence": [ { "id": "F1MBG2", "url": "https://omabrowser.org/oma/group/F1MBG2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "F1MBG2", "url": "https://www.uniprot.org/uniprotkb/F1MBG2" } ], 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"annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MBG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBG2" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 32, "end_pos": 67, "start_aa": "Pro", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.21.105", "ec_name": "Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.", "evidence": [ { "id": "3.4.21.105", "database": "BRENDA Enzymes", "url": 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"https://www.uniprot.org/uniprotkb/F1MGQ9", "locus": { "chromosome": "4", "start_pos": 65467521, "end_pos": 65585947, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009390", "url": "https://www.ensembl.org/id/ENSBTAG00000009390" } ] } } ], "crossref": [ { "id": "F1MGQ9", "url": "https://alphafold.ebi.ac.uk/entry/F1MGQ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009390", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009390", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR025257", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025257", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059022", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059022", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SCFSTEW", "url": "https://omabrowser.org/oma/group/SCFSTEW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12473", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12473", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12473:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12473:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13898", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13898", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SK93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGQ9", "url": "https://www.uniprot.org/uniprotkb/F1MGQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGQ9-1", "url": "https://www.uniprot.org/uniprotkb/F1MGQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDTLFVEEVAASLIREFLSRKGLKKTYVTMDQERPRSDLSINSRNDLRKVLHLEFLYKENKAKENPLKTNLELITRYFLDHFGNIGNNVTQETRIPELSVPKKSNKLPLRSSETTLVNIYHLADEDETWRTSLSEISKARHDSLDGDVLGHFVSSKRSSHKSRPIKTVAGESPTVASAWEKTDKLPMSEPSLDTKRMGEKVRPKSGLIVRGMMAGPIASSPQDSLRKRSLRRSPALSSATQPHKEGSPQEPELSTHTSTCPTPLEGPASSTASTSRSPQGPLSELTWEKQRTSPGSPPHLPGKGLLPRGSGRWRDLSEDSPAVDSGSEAIRTPPKFSLSSGNVPKTQERPERAFERQGSQPASLRKNQLSVSNKLEGDLDVLQLEDVGDELVREEIILSPVSSVLKLQVVSKPIDLSVAKDIKTILFGSSFCCFSDEWKLQSFSFNDSVSLKYGIVQNKGGPCGVLAAVQGCVLQKLLFEGDSSTDCARLQPSNARRTHCLALAIADIVWRAGGCERAVVTLASGTQHFSPTGKYKADGVLETLILHSLTCYEELVTFLQQSIHQFEAGPYGCVLLTLSAILSRSTELVRQDFDVPTSHLIGAHGYCTQELVNLLLTGKAVSNVFNDVVELDSGNGDVTLLKGISTRSDIGFLSLFEHYKCRRVGCFLKTPRFPIWVVCSESHFSVLFSQQLELLRDWRAERLFDLYYYDGLANQQEQIRLTVDTTQTVPEDRDNGLVPPLELCIRTKWKGASVNWNGSEPIL", "length": 763, "header": "tr|F1MGQ9-1|F1MGQ9_BOVIN Isoform 1 of Ubiquitin carboxyl-terminal hydrolase MINDY OS=Bos taurus OX=9913 GN=MINDY4 PE=3 SV=4 CANONICAL=F1MGQ9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK93/entry", "sequence": { "sequence": "MDTLFVEEVAASLIREFLSRKGLKKTYVTMDQERPRSDLSINSRNDLRKVLHLEFLYKENKAKENPLKTNLELITRYFLDHFGNIGNNVTQETRIPELSVPKKSNKLPLRSSETTLVNIYHLADEDETWRTSLSEISKARHDSLDGDVLGHFVSSKRSSHKSRPIKTVAGESPTVASAWEKTDKLPMSEPSLDTKRMGEKVRPKSGLIVRGMMAGPIASSPQDSLRKRSLRRSPALSSATQPHKEGSPQEPELSTHTSTCPTPLEGPASSTASTSRSPQGPLSELTWEKQRTSPGSPPHLPGKGLLPRGSGRWRDLSEDSPAVDSGSEAIRTPPKFSLSSGNVPKTQERPERAFERQGSQPASLRKNQLSVSNKLEGDLDVLQLEDVGDELVREEIILSPVSSVLKLQVVSKPIDLSVAKGGPCGVLAAVQGCVLQKLLFEGDSSTDCARLQPSNARRTHCLALAIADIVWRAGGCERAVVTLASGTQHFSPTGKYKADGVLETLILHSLTCYEELVTFLQQSIHQFEAGPYGCVLLTLSAILSRSTELVRQDFDVPTSHLIGAHGYCTQELVNLLLTGKAVSNVFNDVVELDSGNGDVTLLKGISTRSDIGFLSLFEHYKCVPGTLRELGARRPRSPAPGDPQEGGRRRAQLQVLGPGSSLNHRGSRKSGLLPEDPEVPHLGGVQREPLQRPLQPAA", "length": 698, "header": "tr|A0AAA9SK93-1|F1MGQ9_BOVIN Computationally mapped isoform of Ubiquitin carboxyl-terminal hydrolase MINDY OS=Bos taurus OX=9913 GN=MINDY4 PE=3 SV=1 CANONICAL=F1MGQ9-1" }, "locus": { "chromosome": "4", "start_pos": 65585911, "end_pos": 65480246, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090259.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090259.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083014.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083014.1" } ] } }, { "isoform_ac": "A0AAA9TRR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRR6/entry", "sequence": { "sequence": "MDTLFVEEVAASLIREFLSRKGLKKTYVTMDQERPRSDLSINSRNDLRKVLHLEFLYKENKAKENPLKTNLELITRYFLDHFGNIGNNVTQETRIPELSVPKKSNKLPLRSSETTLVNIYHLADEDETWRTSLSEISKARHDSLDGDVLGHFVSSKRSSHKSRPIKTVAGESPTVASAWEKTDKLPMSEPSLDTKRMGEKVRPKSGLIVRGMMAGPIASSPQDSLRKRSLRRSPALSSATQPHKEGSPQEPELSTHTSTCPTPLEGPASSTASTSRSPQGPLSELTWEKQRTSPGSPPHLPGKGLLPRGSGRWRDLSEDSPAVDSGSEAIRTPPKFSLSSGNVPKTQERPERAFERQGSQPASLRKNQLSVSNKLEGDLDVLQLEDVGDELVREEIILSPVSSVLKLQVVSKPIDLSVAKDIKTILFGSSFCCFSDEWKLQSFSFNDSVSLKYGIVQNKGGPCGVLAAVQGCVLQKLLFEGDSSTDCARLQPSNARRTHCLALAIADIVWRAGGCERAVVTLASGTQHFSPTGKYKADGVLETLILHSLTCYEELVTFLQQSIHQFEAGPYGCVLLTLSAILSRSTELVRQDFDVPTSHLIGAHGYCTQELVNLLLTGKAVSNVFNDVVELDSGNGDVTLLKGISTRSDIGFLSLFEHYKCVPGTLRELGARRPRSPAPGDPQEGGRRRAQLQVLGPGSSLNHRGSRKSAVSLPSKVHTHSQQTPGKGLQGICSVTVRQNGRSCHVCLCGPGGLLQ", "length": 756, "header": "tr|A0AAA9TRR6-1|F1MGQ9_BOVIN Computationally mapped isoform of Ubiquitin carboxyl-terminal hydrolase MINDY OS=Bos taurus OX=9913 GN=MINDY4 PE=3 SV=1 CANONICAL=F1MGQ9-1" }, "locus": { "chromosome": "4", "start_pos": 65585911, "end_pos": 65486343, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135462.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135462.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099729.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099729.1" } ] } }, { "isoform_ac": "F1MGQ9-1", "url": "https://www.uniprot.org/uniprotkb/F1MGQ9/entry", "sequence": { "sequence": "MDTLFVEEVAASLIREFLSRKGLKKTYVTMDQERPRSDLSINSRNDLRKVLHLEFLYKENKAKENPLKTNLELITRYFLDHFGNIGNNVTQETRIPELSVPKKSNKLPLRSSETTLVNIYHLADEDETWRTSLSEISKARHDSLDGDVLGHFVSSKRSSHKSRPIKTVAGESPTVASAWEKTDKLPMSEPSLDTKRMGEKVRPKSGLIVRGMMAGPIASSPQDSLRKRSLRRSPALSSATQPHKEGSPQEPELSTHTSTCPTPLEGPASSTASTSRSPQGPLSELTWEKQRTSPGSPPHLPGKGLLPRGSGRWRDLSEDSPAVDSGSEAIRTPPKFSLSSGNVPKTQERPERAFERQGSQPASLRKNQLSVSNKLEGDLDVLQLEDVGDELVREEIILSPVSSVLKLQVVSKPIDLSVAKDIKTILFGSSFCCFSDEWKLQSFSFNDSVSLKYGIVQNKGGPCGVLAAVQGCVLQKLLFEGDSSTDCARLQPSNARRTHCLALAIADIVWRAGGCERAVVTLASGTQHFSPTGKYKADGVLETLILHSLTCYEELVTFLQQSIHQFEAGPYGCVLLTLSAILSRSTELVRQDFDVPTSHLIGAHGYCTQELVNLLLTGKAVSNVFNDVVELDSGNGDVTLLKGISTRSDIGFLSLFEHYKCRRVGCFLKTPRFPIWVVCSESHFSVLFSQQLELLRDWRAERLFDLYYYDGLANQQEQIRLTVDTTQTVPEDRDNGLVPPLELCIRTKWKGASVNWNGSEPIL", "length": 763, "header": "tr|F1MGQ9-1|F1MGQ9_BOVIN Isoform 1 of Ubiquitin carboxyl-terminal hydrolase MINDY OS=Bos taurus OX=9913 GN=MINDY4 PE=3 SV=4 CANONICAL=F1MGQ9-1" }, "locus": { "chromosome": "4", "start_pos": 65585911, "end_pos": 65467872, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012360.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012360.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012360.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012360.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 174, "start_aa": "Thr", "end_pos": 174, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr174", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0M5K7-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase MINDY", "gene_name": "Mindy4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLNKTFMTMDQERPRCELSINSRNDLRRVLHLEFLYKENKTKEKPLKTNLELITRYFLDHFGNTDSTESQEAPIPAIPIPKKNSKLPLRYPEATLVNIYDLSDEDTGRRTSWSETGKARHDNLDGDIFGNFMSSKKNPYKSKPAHMVLGDSLPLVPAWEKVDQLHSSEPGIDMKRTVERTRPKSGLIVRGMMAGPVASSSQDSFRKRSLRRSSTLSRKLQAPEESQQQSEPFVHTPVCPGPQEVSASSSDSFSRSPLGQLNELSIEKPNATPSSQGPCQRDRPRLRSISEDSPLGYSHTEIITTPLRLDLPDGNSRMPQERLERAFKRQGGQPPSLRKSQLVSDRTGDKPDALQLEDVEDELIKEDIVLFPPPSMLKLLTVSKPIDLSLAKEIKTLLFGSTFCCFSEEWKLQNFSFNDIASLKYGIVQNKGGPCGVLAAVQGCVLQKLLFEGDNRINSNLQLQPSDAQRTRCLALAIADILWRAGGKEQAVVALASGTPHFSPTGKYKADGVLETLTLYSLTSSEDLVTFLQQSVHQFEAGPYGCILLTLSAILSRSLELVRQDFDVPTSHLIGAHGYCTQELVNLLLTGRAVSNVFNDVVELDSGDGNITLLRGIEARSDIGFLSLFEHYNVCQVGCFLKTPRFPIWVVCSESHFSILFSLQPELLCDWKSERLFDLYYYDGLANQQEEIRLTVDTTKTAPEDNCSDLVPPLELCIRTKWKGASVNWNGSDPIL", "length": 736 }, "evidence": [ { "id": "F1MGQ9", "url": "https://omabrowser.org/oma/group/F1MGQ9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F8W526-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase MINDY", "gene_name": "mindy4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMGKDVEDVSASLVREYLSRKGLKKTIACMDEELPRTHSSVNNRSDLRSILHLEGLYKKNKAEEHPLKSMLEMIVKDRMSEGGKTKGHRQGDVQAHALDQTMSSSSIDMTETIKRDESCLHNLSSNNPRLSESSRVSQVIVSPQTPSEKRQDKAKTSLDLSSSSRDSLLTMSKEGFLSETKVLDTDSQKNRGSRIRRGIMAGPICSSSQESNRRRPTRKTASSVIETMEDCRQASNWTNGFNTTNTKSKPSAFLQVESSSISNLHKGNIDHDGHERMTKAKQKNSAPSLNLDGLHVLEMVLDDIEYEESLCDISRKILPEYSLDKTSMDQMTAVALKEIIFGSSMACFTEEWKQQSFTFSDTPGLKYGIVQKKGGPCGVLAAVQACVLEKLLFEESSCDSVDQRLEVSSIVRTKCLYLALADVIWRAGNMNRATVAINTGRSVFTPIGRYKSDGILEMITYVTVETLDDLTLVLEQHVRQFESGPFGCILLTISAILSRTIAIVRSDMDVPTSTLIGAHGYCTQELVNLLLCGRAVSNVFDDEMKLDSGNGNFTLLRGIKTRSDIGLLSLFEHYNICKVGSHLKNPTFPIWVVCSESHFSVLFSLSKDLASDHCTENEFDLYYYDGLANQQEPIRLTVYPHSAAKAAAHNDNTDDDLIPPLELCIRTKWPNAVVNWNDTDPIL", "length": 683 }, "evidence": [ { "id": "F1MGQ9", "url": "https://omabrowser.org/oma/group/F1MGQ9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q3UQI9-1", "protein_name": "Probable ubiquitin carboxyl-terminal hydrolase MINDY-4", "gene_name": "Mindy4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDSLYVEEVAASLVREFLSRKGLNKTFVTMDQERPRCELSINSRNDLRKVLHLEFLYKENKAKEKPLRTNLELITRYFLDNVGNTDNSESQEVPIPAIPVPKKNNKLPLRHSETTLVNIYDLSDEDTGRRTSWSEAGKARHDSLDGDILGNFVSSKKPSHKSKAAHVDLGDSLPLVPAWEKVDQLHSSEPGIDVKKTMERTRPKSGLIVRGMMAGPVASSPQDSFRKRSLRRSSALSRKLQTPEEIQQQSEPFVHTPAYLGPQEVPDSSSDSVSRSPLGQLNELSIEKPNVTSSSQGLSQRDRPRLRSVSEDSPLGYSHTEGNSRMAQDQLERAFKRQGVQPPSLRKNQLVSDRTDDKPDALQLEDVEDELIKEDIVLFPPPSMLKLQTVSKPIDLSLAKEIKTLLFGSTFCCFSEEWKLQNFSFNDIASLKYGIVQNKGGPCGVLAAVQGCVLQKLLFEGDNRTNSNLRLQPSDAQRTRCLALAIADILWRAGGKEQAVVALASGTPHFSPTGKYKADGVLETLTLYSLTSSEDLVTFIQQSVHQFEAGPYGCILLTLSAILSRSLELVRQDFDVPTSHLIGAHGYCTQELVNLLLTGRAVSNVFNDVVELDSGDGNITLLRGIEARSDIGFLSLFEHYNVCQVGCFLKTPRFPIWVVCSESHFSILFSLQPELLCDWRSERLFDLYYYDGLANQQEEIRLTVDTTKTAPADSCSDLVPPLELCIRTKWKGASVNWNGSDPIL", "length": 744 }, "evidence": [ { "id": "F1MGQ9", "url": "https://omabrowser.org/oma/group/F1MGQ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q4G0A6-1", "protein_name": "Probable ubiquitin carboxyl-terminal hydrolase MINDY-4", "gene_name": "MINDY4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDSLFVEEVAASLVREFLSRKGLKKTCVTMDQERPRSDLSINNRNDLRKVLHLEFLYKENKAKENPLKTSLELITRYFLDHFGNTANNFTQDTPIPALSVPKKNNKVPSRCSETTLVNIYDLSDEDAGWRTSLSETSKARHDNLDGDVLGNFVSSKRPPHKSKPMQTVPGETPVLTSAWEKIDKLHSEPSLDVKRMGENSRPKSGLIVRGMMSGPIASSPQDSFHRHYLRRSSPSSSSTQPQEESRKVPELFVCTQQDILASSNSSPSRTSLGQLSELTVERQKTTASSPPHLPSKRLPPWDRARPRDPSEDTPAVDGSTDTDRMPLKLYLPGGNSRMTQERLERAFKRQGSQPAPVRKNQLLPSDKVDGELGALRLEDVEDELIREEVILSPVPSVLKLQTASKPIDLSVAKEIKTLLFGSSFCCFNEEWKLQSFSFSNTASLKYGIVQNKGGPCGVLAAVQGCVLQKLLFEGDSKADCAQGLQPSDAHRTRCLVLALADIVWRAGGRERAVVALASRTQQFSPTGKYKADGVLETLTLHSLTCYEDLVTFLQQSIHQFEVGPYGCILLTLSAILSRSTELIRQDFDVPTSHLIGAHGYCTQELVNLLLTGKAVSNVFNDVVELDSGDGNITLLRGIAARSDIGFLSLFEHYNMCQVGCFLKTPRFPIWVVCSESHFSILFSLQPGLLRDWRTERLFDLYYYDGLANQQEQIRLTIDTTQTISEDTDNDLVPPLELCIRTKWKGASVNWNGSDPIL", "length": 757 }, "evidence": [ { "id": "F1MGQ9", "url": "https://omabrowser.org/oma/group/F1MGQ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1MGQ9", "url": "https://www.uniprot.org/uniprotkb/F1MGQ9" } ], "pmid": "" }, { "name": "protein K48-linked deubiquitination", "id": "GO:0071108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071108", "evidence": [ { "database": "UniProtKB", "id": "F1MGQ9", "url": "https://www.uniprot.org/uniprotkb/F1MGQ9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "F1MGQ9", "url": "https://www.uniprot.org/uniprotkb/F1MGQ9" } ], "pmid": "" }, { "name": "K48-linked deubiquitinase activity", "id": "GO:1990380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990380", "evidence": [ { "database": "UniProtKB", "id": "F1MGQ9", "url": "https://www.uniprot.org/uniprotkb/F1MGQ9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MGQ9", "url": "https://www.uniprot.org/uniprotkb/F1MGQ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 446, "end_pos": 448, "annotation": "n_glycosylation_sequon" }, { "start_pos": 757, "end_pos": 759, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MGQ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 763, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MGQ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MGQ9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MGQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGQ9" }, { "id": "SM01174", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01174" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Deubiquitinating enzyme MINDY-3/4 conserved", "eco_id": "ECO_0000259", "start_pos": 423, "end_pos": 758, "start_aa": "Lys", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.19.12", "ec_name": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "3.4.19.12", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.19.12" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 174 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 446, "end_pos": 448 }, { "start_pos": 757, "end_pos": 759 }, { "start_pos": 88, "end_pos": 90 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": 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"table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MDM4-1", "uniprot_ac": "F1MDM4", "uniprot_id": "F1MDM4_BOVIN", "mass": { "chemical_mass": 21429.0, "monoisotopic_mass": 21429.0 }, "refseq": {}, "gene_names": [ { "name": "REEP5", "type": "recommended", "evidence": [ { "id": "F1MDM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDM4" } ] } ], "protein_names": [ { "name": "Receptor expression-enhancing protein", "type": "recommended", "evidence": [ { "id": "F1MDM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDM4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SQT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQT5#function" }, { "database": "UniProtKB", "id": "ARBA00037732", "url": "https://www.uniprot.org/uniprotkb/ARBA00037732#function" }, { "database": "UniProtKB", "id": "A0AAA9RWI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWI8#function" }, { "database": "UniProtKB", "id": "A0AAA9SHN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN0#function" }, { "database": "UniProtKB", "id": "A0A3Q1LFH4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFH4#function" }, { "database": "UniProtKB", "id": "F1MDM4", "url": "https://www.uniprot.org/uniprotkb/F1MDM4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MDM4", "url": "https://www.uniprot.org/uniprotkb/F1MDM4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "REEP5", "url": "https://www.uniprot.org/uniprotkb/F1MDM4", "locus": { "chromosome": "10", "start_pos": 1145330, "end_pos": 1094713, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012804", "url": "https://www.ensembl.org/id/ENSBTAG00000012804" } ] } } ], "crossref": [ { "id": "F1MDM4", "url": "https://alphafold.ebi.ac.uk/entry/F1MDM4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012804", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012804", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR004345", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004345", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DTQYWVV", "url": "https://omabrowser.org/oma/group/DTQYWVV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LFH4", "url": "https://www.orthodb.org/?gene=A0A3Q1LFH4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MDM4", "url": "https://www.orthodb.org/?gene=F1MDM4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12300", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12300", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12300:SF93", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12300:SF93", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LFH4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LFH4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHQ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SHQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQT5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDM4", "url": "https://www.uniprot.org/uniprotkb/F1MDM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDM4-1", "url": "https://www.uniprot.org/uniprotkb/F1MDM4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAAMRQRFDQFLHQKNCMTDLLAKIEAKTGVNRSFIALGVIGLLALYLVFGYGASLLCNLIGFGYPAYVSIKAIESPNKEDDTQWLTYWVVYGVFSIVEFFSDLFLSWFPFYYMLKCGFLLWCMAPSPANGADLLYKRIIRPFFLKHESQVDNVVNDLKDKAKETADTISKEARKAAVSLLGEEKKST", "length": 189, "header": "tr|F1MDM4-1|F1MDM4_BOVIN Isoform 1 of Receptor expression-enhancing protein OS=Bos taurus OX=9913 GN=REEP5 PE=3 SV=1 CANONICAL=F1MDM4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LFH4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFH4/entry", "sequence": { "sequence": "MSAAMRQRFDQFLHQKNCMTDLLAKIEAKTGVNRSFIALGVIGLLALYLVFGYGASLLCNLIGFGYPAYVSIKAIESPNKEDDTQWLTYWVVYGVFSIVEFFSDLFLSWFPFYYMLKPGKPP", "length": 122, "header": "tr|A0A3Q1LFH4-1|F1MDM4_BOVIN Computationally mapped isoform of Receptor expression-enhancing protein OS=Bos taurus OX=9913 GN=REEP5 PE=3 SV=2 CANONICAL=F1MDM4-1" }, "locus": { "chromosome": "10", "start_pos": 1143030, "end_pos": 1094780, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073647.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073647.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056918.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056918.2" } ] } }, { "isoform_ac": "A0AAA9RWI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWI8/entry", "sequence": { "sequence": "MSAAMRQRFDQFLHQKNCMTDLLAKIEAKTGVNRSFIALGVIGLLALYLVFGYGASLLCNLIGFGYPAYVSIKAIESPNKEDDTQWLTYWVVYGVFSIVEFFSDLFLSWFPFYYMLKCGFLLWCMAPSPANGADLLYKRIIRPFFLKHESQVDNVVNDLKDKAKETADTISKEEWNIPVTGEEDPSAQDTGRILKSVIIQVTAVLKSDCKFGAKILKK", "length": 218, "header": "tr|A0AAA9RWI8-1|F1MDM4_BOVIN Computationally mapped isoform of Receptor expression-enhancing protein OS=Bos taurus OX=9913 GN=REEP5 PE=3 SV=1 CANONICAL=F1MDM4-1" }, "locus": { "chromosome": "10", "start_pos": 1141600, "end_pos": 1094780, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123194.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123194.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075482.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075482.1" } ] } }, { "isoform_ac": "A0AAA9SHN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHN0/entry", "sequence": { "sequence": "MSAAMRQRFDQFLHQKNCMTDLLAKIEAKTGVNRSFIALGVIGLLALYLVFGYGASLLCNLIGFGYPAYVSIKAIESPNKEDDTQWLTYWVVYGVFSIVEFFSDLFLSWFPFYYMLKVDSLPAEPAGKPKNTGMGSLSLLQGNFPTQESKWGLLPCRQSLCQLSHQGRPGSLSLLGHYLSCFLHQEKCA", "length": 189, "header": "tr|A0AAA9SHN0-1|F1MDM4_BOVIN Computationally mapped isoform of Receptor expression-enhancing protein OS=Bos taurus OX=9913 GN=REEP5 PE=3 SV=1 CANONICAL=F1MDM4-1" }, "locus": { "chromosome": "10", "start_pos": 1140351, "end_pos": 1094780, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092868.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092868.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084855.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084855.1" } ] } }, { "isoform_ac": "A0AAA9SHQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SHQ5/entry", "sequence": { "sequence": "MSAAMRQRFDQFLHQKNCMTDLLAKIEAKTGVNRSFIALGVIGLLALYLVFGYGASLLCNLIGFGYPAYVSVASCCGAWLPALPTEQTCSTSASSGLSS", "length": 99, "header": "tr|A0AAA9SHQ5-1|F1MDM4_BOVIN Computationally mapped isoform of Receptor expression-enhancing protein OS=Bos taurus OX=9913 GN=REEP5 PE=3 SV=1 CANONICAL=F1MDM4-1" }, "locus": { "chromosome": "10", "start_pos": 1140545, "end_pos": 1094780, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102761.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102761.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084875.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084875.1" } ] } }, { "isoform_ac": "A0AAA9SQT5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQT5/entry", "sequence": { "sequence": "MSAAMRQRFDQFLHQKNCMTDLLAKIEAKTGVNRSFIALGVIGLLALYLVFGYGASLLCNLIGFGYPAYVSIKAIESPNKEDDTQWLTYWVVYGVFSIVEFFSDLFLSWFPFYYMLKCGFLLWCMAPSPANGADLLYKRIIRPFFLKHESQVDNVVNDLKDKAKETADTISKEDCVLPKPCSRTQLQSPSVRSYVSSHPPTLGSPVPFEEPGKPP", "length": 215, "header": "tr|A0AAA9SQT5-1|F1MDM4_BOVIN Computationally mapped isoform of Receptor expression-enhancing protein OS=Bos taurus OX=9913 GN=REEP5 PE=3 SV=1 CANONICAL=F1MDM4-1" }, "locus": { "chromosome": "10", "start_pos": 1143030, "end_pos": 1094780, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122929.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122929.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087713.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087713.1" } ] } }, { "isoform_ac": "F1MDM4-1", "url": "https://www.uniprot.org/uniprotkb/F1MDM4/entry", "sequence": { "sequence": "MSAAMRQRFDQFLHQKNCMTDLLAKIEAKTGVNRSFIALGVIGLLALYLVFGYGASLLCNLIGFGYPAYVSIKAIESPNKEDDTQWLTYWVVYGVFSIVEFFSDLFLSWFPFYYMLKCGFLLWCMAPSPANGADLLYKRIIRPFFLKHESQVDNVVNDLKDKAKETADTISKEARKAAVSLLGEEKKST", "length": 189, "header": "tr|F1MDM4-1|F1MDM4_BOVIN Isoform 1 of Receptor expression-enhancing protein OS=Bos taurus OX=9913 GN=REEP5 PE=3 SV=1 CANONICAL=F1MDM4-1" }, "locus": { "chromosome": "10", "start_pos": 1143062, "end_pos": 1094780, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017009.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017009.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017009.4", "url": "https://www.ensembl.org/id/ENSBTAP00000017009.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A1Z9M2-1", "protein_name": "Receptor expression-enhancing protein", "gene_name": "ReepB", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MATQVKQFLNGYKDDVSKSLRDASKPWTKVFDTVEEKTGVDRVNIFVGAVGLCAIYLIFGWGAQLLCNIIGVLYPAYISIHAIESSTKQDDTKWLIYWVTFGIFTVIEFFSSLLTSVIPFYWLLKCAFLIWCMLPTEQNGSTIIYNKLVRPYFLKHHESVDRIIDDGMKKAAGVLKHD", "length": 178 }, "evidence": [ { "id": "F1MDM4", "url": "https://omabrowser.org/oma/group/F1MDM4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "B2RZ37-1", "protein_name": "Receptor expression-enhancing protein 5", "gene_name": "Reep5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAAMRERFDRFLHEKNCMTDLLAKLEAKTGVNRSFIALGVIGLVALYLVFGYGASLLCNLIGFGYPAYISMKAIESPNKDDDTQWLTYWVVYGVFSIAEFFSDLFLSWFPFYYMLKCGFLLWCMAPSPSNGAELLYRRVIRPIFLKHESQVDSVVKDVKDKAKETADAISKEVKKATVNLLGDEKKST", "length": 189 }, "evidence": [ { "id": "F1MDM4", "url": "https://omabrowser.org/oma/group/F1MDM4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RLG5-1", "protein_name": "Receptor expression-enhancing protein", "gene_name": "REEP5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSAAMRQRFDQFLHQKNYLTDILAKIEAKTGVNRSYIALGVIGLVALYLVFGYGASLLCNLIGFGYPAYVSIKAIESPNKEDDTQWLTYWVVYGVFSIAEFFSDLFLSWFPFYYMLKCGFLLWCMAPSPANGADLLYQRIIRPFFLKHESQVDNVVSDLKDKAKETADAITKEAKKAAVNLLGEEKKST", "length": 189 }, "evidence": [ { "id": "F1MDM4", "url": "https://omabrowser.org/oma/group/F1MDM4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q00765-1", "protein_name": "Receptor expression-enhancing protein 5", "gene_name": "REEP5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAAMRERFDRFLHEKNCMTDLLAKLEAKTGVNRSFIALGVIGLVALYLVFGYGASLLCNLIGFGYPAYISIKAIESPNKEDDTQWLTYWVVYGVFSIAEFFSDIFLSWFPFYYMLKCGFLLWCMAPSPSNGAELLYKRIIRPFFLKHESQMDSVVKDLKDKAKETADAITKEAKKATVNLLGEEKKST", "length": 189 }, "evidence": [ { "id": "F1MDM4", "url": "https://omabrowser.org/oma/group/F1MDM4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q60870-1", "protein_name": "Receptor expression-enhancing protein 5", "gene_name": "Reep5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRERFDRFLHEKNCMTDLLAKLEAKTGVNRSFIALGVIGLVALYLVFGYGASLLCNLIGFGYPAYISMKAIESPNKDDDTQWLTYWVVYGVFSIAEFFSDLFLSWLPFYYMLKCGFLLWCMAPSPANGAEMLYRRIIRPIFLRHESQVDSVVKDVKDKAKETADAISKEVKKATVNLLGDVKKST", "length": 185 }, "evidence": [ { "id": "F1MDM4", "url": "https://omabrowser.org/oma/group/F1MDM4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6PBX9-1", "protein_name": "Receptor expression-enhancing protein 5", "gene_name": "reep5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAAALKQRFDNALHEKNMVTDLLAKIEAKTGVNRSYIAYAVIAFIAIYLVIGYGASLLCNLIGFVYPAYISIKAIESPAKDDDTKWLTYWVVYGVFSVVEFFADIFLSWFPFYFLAKCAFLVWCMAPTPSNGSIMLYTRIIRPFFLKNEAKIDNVMKDLTDKAAGAADKIKDEAKKATANIMFEEKKHY", "length": 189 }, "evidence": [ { "id": "F1MDM4", "url": "https://omabrowser.org/oma/group/F1MDM4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "sarcoplasmic reticulum membrane", "id": "GO:0033017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033017", "evidence": [ { "database": "UniProtKB", "id": "F1MDM4", "url": "https://www.uniprot.org/uniprotkb/F1MDM4" } ], "pmid": "" }, { "name": "endoplasmic reticulum tubular network", "id": "GO:0071782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071782", "evidence": [ { "database": "UniProtKB", "id": "F1MDM4", "url": "https://www.uniprot.org/uniprotkb/F1MDM4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MDM4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 189, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MDM4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MDM4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 33, "end_pos": 35 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MG29-1", "uniprot_ac": "F1MG29", "uniprot_id": "F1MG29_BOVIN", "mass": { "chemical_mass": 30234.0, "monoisotopic_mass": 30234.0 }, "refseq": { "ac": "NP_001193754", "name": "testis-specific serine/threonine-protein kinase 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193754" }, "gene_names": [ { "name": "TSSK3", "type": "recommended", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "name": "TSSK3", "type": "synonym", "evidence": [ { "id": "NP_001193754", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193754" } ] } ], "protein_names": [ { "name": "Testis-specific serine/threonine-protein kinase 3", "type": "recommended", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29/entry#names_and_taxonomy" } ] }, { "name": "Serine/threonine-protein kinase 22C", "type": "synonym", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29/entry#names_and_taxonomy" } ] }, { "name": "testis-specific serine/threonine-protein kinase 3", "type": "synonym", "evidence": [ { "id": "NP_001193754", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193754" } ] } ], "function": [ { "annotation": "Serine/threonine protein kinase required for spermatid development and male fertility.", "evidence": [ { "database": "UniProtKB", "id": "F1MG29", "url": "https://www.uniprot.org/uniprotkb/F1MG29#function" }, { "database": "UniProtKB", "id": "ARBA00057250", "url": "https://www.uniprot.org/uniprotkb/ARBA00057250#function" }, { "database": "UniProtKB", "id": "A0AAA9SQZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MG29", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TSSK3", "url": "https://www.uniprot.org/uniprotkb/F1MG29", "locus": { "chromosome": "2", "start_pos": 121198970, "end_pos": 121206119, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020652", "url": "https://www.ensembl.org/id/ENSBTAG00000020652" } ] } } ], "crossref": [ { "id": "F1MG29", "url": "https://alphafold.ebi.ac.uk/entry/F1MG29", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020652", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020652", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14163", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14163", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538659", "url": "https://www.ncbi.nlm.nih.gov/gene/538659", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538659", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538659", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HVMLCAS", "url": "https://omabrowser.org/oma/group/HVMLCAS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MG29", "url": "https://www.orthodb.org/?gene=F1MG29", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24346", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24346", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24346:SF102", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24346:SF102", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193754", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S295", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S295", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S295-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S295-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG29", "url": "https://www.uniprot.org/uniprotkb/F1MG29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG29-1", "url": "https://www.uniprot.org/uniprotkb/F1MG29-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDFLLSNGYQLGKTIGEGTYSKVKEAVSKKHQRKVAIKIIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKIYLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSRRELSQTFCGSTAYAAPEVLQGIPHDSRKGDIWSMGVVLHVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLGISAECQDLLKRLLEPDMILRPSIEEVSWHPWLASTS", "length": 269, "header": "tr|F1MG29-1|F1MG29_BOVIN Isoform 1 of Testis-specific serine/threonine-protein kinase 3 OS=Bos taurus OX=9913 GN=TSSK3 PE=3 SV=3 CANONICAL=F1MG29-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S295-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S295/entry", "sequence": { "sequence": "MPAQSLQSCPTLRNPVDCSLPGSSVHGILQAKFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKIYLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSRRELSQTFCGSTAYAAPEVLQGIPHDSRKGDIWSMGVVLHVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLGISAECQDLLKRLLEPDMILRPSIEEVSWHPWLASTS", "length": 252, "header": "tr|A0AAA9S295-1|F1MG29_BOVIN Computationally mapped isoform of Testis-specific serine/threonine-protein kinase 3 OS=Bos taurus OX=9913 GN=TSSK3 PE=3 SV=1 CANONICAL=F1MG29-1" }, "locus": { "chromosome": "2", "start_pos": 121203979, "end_pos": 121200049, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124827.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124827.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076222.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076222.1" } ] } }, { "isoform_ac": "A0AAA9SQZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ1/entry", "sequence": { "sequence": "MEDFLLSNGYQLGKTIGEGTYSKVKEAVSKKHQRKVAIKIIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKIYLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSRRELSQTFCGSTAYAAPEVLQGIPHDSRKGDIWSMGVVLHVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLGISAECQDLLKRLLEPDMILRPSIEEV", "length": 259, "header": "tr|A0AAA9SQZ1-1|F1MG29_BOVIN Computationally mapped isoform of Testis-specific serine/threonine-protein kinase 3 OS=Bos taurus OX=9913 GN=TSSK3 PE=3 SV=1 CANONICAL=F1MG29-1" }, "locus": { "chromosome": "2", "start_pos": 121201566, "end_pos": 121199150, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103259.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103259.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087766.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087766.1" } ] } }, { "isoform_ac": "A0AAA9TQX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQX0/entry", "sequence": { "sequence": "MGASTEQSLASRAERRHRSNPYRRGYDSLPGAGAGHGEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKIYLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSRRELSQTFCGSTAYAAPEVLQGIPHDSRKGDIWSMGVVLHVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLGISAECQDLLKRLLEPDMILRPSIEEVSWHPWLASTS", "length": 258, "header": "tr|A0AAA9TQX0-1|F1MG29_BOVIN Computationally mapped isoform of Testis-specific serine/threonine-protein kinase 3 OS=Bos taurus OX=9913 GN=TSSK3 PE=3 SV=1 CANONICAL=F1MG29-1" }, "locus": { "chromosome": "2", "start_pos": 121201995, "end_pos": 121200049, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121096.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121096.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099408.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099408.1" } ] } }, { "isoform_ac": "F1MG29-1", "url": "https://www.uniprot.org/uniprotkb/F1MG29/entry", "sequence": { "sequence": "MEDFLLSNGYQLGKTIGEGTYSKVKEAVSKKHQRKVAIKIIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKIYLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSRRELSQTFCGSTAYAAPEVLQGIPHDSRKGDIWSMGVVLHVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLGISAECQDLLKRLLEPDMILRPSIEEVSWHPWLASTS", "length": 269, "header": "tr|F1MG29-1|F1MG29_BOVIN Isoform 1 of Testis-specific serine/threonine-protein kinase 3 OS=Bos taurus OX=9913 GN=TSSK3 PE=3 SV=3 CANONICAL=F1MG29-1" }, "locus": { "chromosome": "2", "start_pos": 121201566, "end_pos": 121200049, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027520.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027520.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027520.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027520.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:538659", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538659", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7I870-1", "protein_name": "Testis-specific serine/threonine-protein kinase 3", "gene_name": "Tssk3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKIIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIRVYEMLESADGKIYLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSRRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLGISTECQDLLKRLLEPDMILRPSIEEVSWHPWLAST", "length": 268 }, "evidence": [ { "id": "F1MG29", "url": "https://omabrowser.org/oma/group/F1MG29/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3L7T3-1", "protein_name": "Testis-specific serine/threonine-protein kinase 3", "gene_name": "TSSK3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEDFLLSNGYQLGKTIGEGTYSKVKEAVSKKHQRKVAIKIIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKIYLVMELAEGGDVFDCVLNGGPLPESRARALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSCRELSQTFCGSTAYAAPEVLQGIPHDSKKGDIWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLGISAECQDLLKRLLEPDMTLRPSIEEVSWHPWLAST", "length": 268 }, "evidence": [ { "id": "F1MG29", "url": "https://omabrowser.org/oma/group/F1MG29/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6V9Y3-1", "protein_name": "Testis-specific serine/threonine-protein kinase 3", "gene_name": "Tssk3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKIIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIRVYEMLESADGKIYLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSRRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLGISTECQDLLKRLLEPDMILRPSIEEVSWHPWLAST", "length": 268 }, "evidence": [ { "id": "F1MG29", "url": "https://omabrowser.org/oma/group/F1MG29/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96PN8-1", "protein_name": "Testis-specific serine/threonine-protein kinase 3", "gene_name": "TSSK3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEPDMILRPSIEEVSWHPWLAST", "length": 268 }, "evidence": [ { "id": "F1MG29", "url": "https://omabrowser.org/oma/group/F1MG29/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "F1MG29", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MG29", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MG29", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "F1MG29", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ], "pmid": "" }, { "name": "manganese ion binding", "id": "GO:0030145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030145", "evidence": [ { "database": "UniProtKB", "id": "F1MG29", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "F1MG29", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MG29", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ], "pmid": "" }, { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "F1MG29", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "F1MG29", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "F1MG29", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", 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"ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": 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"ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": 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}, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": 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"o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MDZ2-1", "uniprot_ac": "F1MDZ2", "uniprot_id": "F1MDZ2_BOVIN", "mass": { "chemical_mass": 103129.0, "monoisotopic_mass": 103129.0 }, "refseq": {}, "gene_names": [ { "name": "NEFM", "type": "recommended", "evidence": [ { "id": "F1MDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2" } ] } ], "protein_names": [ { "name": "Neurofilament medium polypeptide", "type": "recommended", "evidence": [ { "id": "F1MDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2/entry#names_and_taxonomy" } ] }, { "name": "160 kDa neurofilament protein", "type": "synonym", "evidence": [ { "id": "F1MDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2/entry#names_and_taxonomy" } ] }, { "name": "Neurofilament 3", "type": "synonym", "evidence": [ { "id": "F1MDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2/entry#names_and_taxonomy" } ] }, { "name": "Neurofilament triplet M protein", "type": "synonym", "evidence": [ { "id": "F1MDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.", "evidence": [ { "database": "UniProtKB", "id": "F1MDZ2", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2#function" }, { "database": "UniProtKB", "id": "ARBA00046027", "url": "https://www.uniprot.org/uniprotkb/ARBA00046027#function" }, { "database": "UniProtKB", "id": "A0AAA9SR00", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR00#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MDZ2", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NEFM", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2", "locus": { "chromosome": "8", "start_pos": 72186744, "end_pos": 72181225, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039530", "url": "https://www.ensembl.org/id/ENSBTAG00000039530" } ] } } ], "crossref": [ { "id": "F1MDZ2", "url": "https://alphafold.ebi.ac.uk/entry/F1MDZ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039530", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039530", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050405", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050405", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TTYQDTI", "url": "https://omabrowser.org/oma/group/TTYQDTI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MDZ2", "url": "https://www.orthodb.org/?gene=F1MDZ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45652", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45652", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45652:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45652:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04732", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04732", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SR00", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR00-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDZ2", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDZ2-1", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSYTLDSLGNPSAYRRVTETRSSFSRISGSPSSGFRSQSWSRGSPSTVSSSYKRSALAPRLTYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEESSLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRQPSIAISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSVKEEVKEEEAEEKEEKEEAEEEVVAAKKSPVKATAPELKEEEGEKEEEEGQEEEEEEEEAAKSDQAEEGGSEKEGSSEKEEGEQEEEGETEAEGEGEEAAAEAKEEKKMEEKAEEVAPKEELAAEAKVEKPEKAKSPVAKSPTTKSPTAKSPEAKSPTAKSPTAKSPVAKSPTAKSPTAKSPEAKSPEAKSPTAKSPTAKSPAAKSPAAKSPVEEVKPKAEAGAEKGEQKEKVEEEKKEAKESPKEEKAEKKEEKAKDVPEKKKAESPVKAESPVKEEVPAKPVKVSPEKEAKEEEKPQEKEKEKEKVEEVGGKEEGGLKESRKEDIAINGEVEGKEEEQETKEKGSGGEEEKGVVTNGLDVSPGDEKKGGDKSEEKVVVTKMVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD", "length": 926, "header": "tr|F1MDZ2-1|F1MDZ2_BOVIN Isoform 1 of Neurofilament medium polypeptide OS=Bos taurus OX=9913 GN=NEFM PE=3 SV=3 CANONICAL=F1MDZ2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SR00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR00/entry", "sequence": { "sequence": "MSYTLDSLGNPSAYRRVTETRSSFSRISGSPSSGFRSQSWSRGSPSTVSSSYKRSALAPRLTYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEESSLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRQPSIAISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSVKEEVKEEEAEEKEEKEEAEEEVVAAKKSPVKATAPELKEEEGEKEEEEGQEEEEEEEEAAKSDQAEEGGSEKEGSSEKEEGEQEEEGETEAEGEGEEAAAEAKEEKKMEEKAEEVAPKEELAAEAKVEKPEKAKSPVAKSPTTKSPTAKSPEAKSPEAKSPTAKSPTAKSPAAKSPAAKSPVEEVKPKAEAGAEKGEQKEKVEEEKKEAKESPKEEKAEKKEEKAKDVPEKKKAESPVKAESPVKEEVPAKPVKVSPEKEAKEEEKPQEKEKEKEKVEEVGGKEEGGLKESRKEDIAINGEVEGKEEEQETKEKGSGGEEEKGVVTNGLDVSPGDEKKGGDKSEEKVVVTKMVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD", "length": 896, "header": "tr|A0AAA9SR00-1|F1MDZ2_BOVIN Computationally mapped isoform of Neurofilament medium polypeptide OS=Bos taurus OX=9913 GN=NEFM PE=3 SV=1 CANONICAL=F1MDZ2-1" }, "locus": { "chromosome": "8", "start_pos": 72186207, "end_pos": 72181269, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130235.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130235.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085389.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085389.1" } ] } }, { "isoform_ac": "F1MDZ2-1", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2/entry", "sequence": { "sequence": "MSYTLDSLGNPSAYRRVTETRSSFSRISGSPSSGFRSQSWSRGSPSTVSSSYKRSALAPRLTYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEESSLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRQPSIAISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSVKEEVKEEEAEEKEEKEEAEEEVVAAKKSPVKATAPELKEEEGEKEEEEGQEEEEEEEEAAKSDQAEEGGSEKEGSSEKEEGEQEEEGETEAEGEGEEAAAEAKEEKKMEEKAEEVAPKEELAAEAKVEKPEKAKSPVAKSPTTKSPTAKSPEAKSPTAKSPTAKSPVAKSPTAKSPTAKSPEAKSPEAKSPTAKSPTAKSPAAKSPAAKSPVEEVKPKAEAGAEKGEQKEKVEEEKKEAKESPKEEKAEKKEEKAKDVPEKKKAESPVKAESPVKEEVPAKPVKVSPEKEAKEEEKPQEKEKEKEKVEEVGGKEEGGLKESRKEDIAINGEVEGKEEEQETKEKGSGGEEEKGVVTNGLDVSPGDEKKGGDKSEEKVVVTKMVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD", "length": 926, "header": "tr|F1MDZ2-1|F1MDZ2_BOVIN Isoform 1 of Neurofilament medium polypeptide OS=Bos taurus OX=9913 GN=NEFM PE=3 SV=3 CANONICAL=F1MDZ2-1" }, "locus": { "chromosome": "8", "start_pos": 72186207, "end_pos": 72181269, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036581.5", "url": "https://www.ensembl.org/id/ENSBTAT00000036581.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036438.5", "url": "https://www.ensembl.org/id/ENSBTAP00000036438.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1QCR7-1", "protein_name": "Neurofilament, medium polypeptide a", "gene_name": "nefma", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSYPIDTIGSPYRRVMDTRTSYSSPSSGFRSQTWSRTSPSSSSYKRSFNVPVARAYGSAVLSSADSLDFTQNSIINGDYKRSNEKEQLQGLNDRFAGYIDKVHFLEQQNQQIEAEIQALRQKQVSQSQLGELYDQELQELRSMLEQTHHEKAQIQLDTDHIEEDIQRLRDRFDEEARIREETEAIVRALKKDMGDSALVKAELEKKVQSLQDEIAFIRNNHQEEISDLLAQVQASQITVEKRDYQKADITDALREIRSQLEGHSTQNLQQVEDWFMCRYSKLTEAAEQNKSAIKSARDEISDYRRQLQSKTVELESVRGTKESLERQLNDIEDRHNNDLASLQETIHQLENELKSTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEESHFSTFPYRQTVTKGPKVKSEPPKLKVQHKFVEEIIEETRVEDEKSEMDEALAEMAEELSAAKEDEEGGEEEGEAEEGEEGGDDEEGEKEDEGEGEEEEVVASTQAKVASAAPAEEEEEGEKEGGDEEQEEEEEAGKGDEEEEKGEEEEGEEEKKEEEAEEEAEESKAPEAKASPESEKAEEKQASGGEEEAEEEGDENQEGDAGSDKGSTDEKEVEVKEQPKKAEPEAAKEDKKGKEEKEEAKSEKEKATVTETKAESPKAESPKAESPKAESPKSESPKSESPKKETPKTEAPKKDPPKSEPPKTESPKKEEPKAEPSKKETPKSEPSKAEPKEDFPKPADEKATKKSETEKEPEDKKKEATVNGDMGKKDDKKVSDKKEVISNGVDESPTKDESSQRVVITKTVETITTGEDGVKQVTKTVTVTEKGEEVQETVQEKVVSKPAEKQAVKATEAD", "length": 849 }, "evidence": [ { "id": "F1MDZ2", "url": "https://omabrowser.org/oma/group/F1MDZ2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1RJU6-1", "protein_name": "Neurofilament medium polypeptide", "gene_name": "NEFM", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSYTLDSLGNPSAYRRGTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSALAPRLTYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLELVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISSALKEIRSQLECHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRQPSITISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAIAEELAVSMKEEVKEEEAEEKEEKQEAEEVVAAKKSPVKAAAPELKGEEEGEKEEGEGQEEEEEEEEEGAKSDQAEEGGSEKEVSSEKEEGEQEEEGEIEAEGEGEEAEAKEEKKVEEKREEVAPKEELVAEAKVEKPEKAKSPVSKSPVEEVKPKAEAGVGKGEQKEEVEKVEEEKKEAAKESPKEEKVEKKEEKPKDLPEKKKAESPVKEEAGKVSPEKAPSPAKEEAGKVSPEKAPSPAKEEAGKVSPEKAPSPAKEEAGKVSPEKAPSPSKEEAGKVSPEKAPSPSKEEAGKVSPEKAPSPSKEEAGKVSPEKDAKEEKPQQKKEKVEGEGGKEEGGLKESRKEDIAINGEVEGKEEQETKEKGSGGEEEKGVVTNGLDLSPGDRSEEKVVVTKKVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD", "length": 934 }, "evidence": [ { "id": "F1MDZ2", "url": "https://omabrowser.org/oma/group/F1MDZ2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GV00-1", "protein_name": "Neurofilament medium polypeptide", "gene_name": "Nefm", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSALAPRLAYSSAMLSSAESSLDFSQSSSLLNGGSGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQVSHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEESSMVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLECHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFSGSITGPLYTHRQPSVTISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEDTLTAIAEELAASAKEEKEEEAEEKEEDQEAEKSPVKSPEAKEEEEEEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKDEGEQEEEGETEAEGEGEEVEAKEEKKTEEKAEEVAAKEEIKVEKPEKAKSPVPKSPVEEVKPKPETKAEKGEQKEEEKVKEEKKEVIKETPKEEKVEKKEEKPKDVPEKKAESPVKEKAVEEVITITKSVKVSLEKDTKEDKPQPQEKVTEKEKAEEEGGSEEEESDRSPQESKKEDIAINGEVEGKEEEQETQEKGSGREEEKGVVTNGLDVSPADEKKGDDKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQGD", "length": 842 }, "evidence": [ { "id": "F1MDZ2", "url": "https://omabrowser.org/oma/group/F1MDZ2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P07197-1", "protein_name": "Neurofilament medium polypeptide", "gene_name": "NEFM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSMLAPRLAYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD", "length": 916 }, "evidence": [ { "id": "F1MDZ2", "url": "https://omabrowser.org/oma/group/F1MDZ2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P08553-1", "protein_name": "Neurofilament medium polypeptide", "gene_name": "Nefm", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSALAPRLAYSSAMLSSAESSLDFSQSSSLLNGGSGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEESSMVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLECHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFSGSITGPLYTHRQPSVTISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEETLTAIAEELAASAKEEKEEAEEKEEEPEAEKSPVKSPEAKEEEEEGEKEEEEEGQEEEEEEDEGVKSDQAEEGGSEKEGSSEKDEGEQEEEEGETEAEGEGEEAEAKEEKKIEGKVEEVAVKEEIKVEKPEKAKSPMPKSPVEEVKPKPEAKAGKGEQKEEEKVEEEKKEVTKESPKEEKVEKKEEKPKDVADKKKAESPVKEKAVEEVITISKSVKVSLEKDTKEEKPQPQEKVKEKAEEEGGSEEEGSDRSPQESKKEDIAINGEVEGKEEEEQETQEKGSGREEEKGVVTNGLDVSPAEEKKGEDSSDDKVVVTKKVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQGD", "length": 848 }, "evidence": [ { "id": "F1MDZ2", "url": "https://omabrowser.org/oma/group/F1MDZ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P12839-1", "protein_name": "Neurofilament medium polypeptide", "gene_name": "Nefm", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSYTLDSLGNPSAYRRVPTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSALAPRLAYSSAMLSSAESSLDFSQSSSLLNGGSGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIHALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRAVRKDIEESSMVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLECHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFSGSITGPLYTHRQPSVTISSKIQKTKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEDALTVIAEELAASAKEEKEEAEEKEEEPEVEKSPVKSPEAKEEEEGEKEEEEEGQEEEEEEDEGVKSDQAEEGGSEKEGSSEKDEGEQEEEGETEAEGEGEEAEAKEEKKTEGKVEEMAIKEEIKVEKPEKAKSPVPKSPVEEVKPKPEAKAGKDEQKEEEKVEEKKEVAKESPKEEKVEKKEEKPKDVPDKKKAESPVKEKAVEEMITITKSVKVSLEKDTKEEKPQQQEKVKEKAEEEGGSEEEVGDKSPQESKKEDIAINGEVEGKEEEEQETQEKGSGQEEEKGVVTNGLDVSPAEEKKGEDRSDDKVVVTKKVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQGD", "length": 846 }, "evidence": [ { "id": "F1MDZ2", "url": "https://omabrowser.org/oma/group/F1MDZ2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "F1MDZ2", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2" } ], "pmid": "" }, { "name": "intermediate filament", "id": "GO:0005882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005882", "evidence": [ { "database": "UniProtKB", "id": "F1MDZ2", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2" } ], "pmid": "" }, { "name": "postsynaptic intermediate filament cytoskeleton", "id": "GO:0099160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099160", "evidence": [ { "database": "UniProtKB", "id": "F1MDZ2", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "F1MDZ2", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2" } ], "pmid": "" }, { "name": "structural constituent of cytoskeleton", "id": "GO:0005200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", "evidence": [ { "database": "UniProtKB", "id": "F1MDZ2", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "neurofilament bundle assembly", "id": "GO:0033693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033693", "evidence": [ { "database": "UniProtKB", "id": "F1MDZ2", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MDZ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 926, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MDZ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MDZ2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MDZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDZ2" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 101, "end_pos": 412, "start_aa": "Glu", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MB94-1", "uniprot_ac": "F1MB94", "uniprot_id": "F1MB94_BOVIN", "mass": { "chemical_mass": 47676.0, "monoisotopic_mass": 47676.0 }, "refseq": {}, "gene_names": [ { "name": "SRFBP1", "type": "recommended", "evidence": [ { "id": "F1MB94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB94" } ] } ], "protein_names": [ { "name": "Serum response factor-binding protein 1", "type": "recommended", "evidence": [ { "id": "F1MB94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB94/entry#names_and_taxonomy" } ] }, { "name": "SRF-dependent transcription regulation-associated protein", "type": "synonym", "evidence": [ { "id": "F1MB94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB94/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SU87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU87#function" }, { "database": "UniProtKB", "id": "ARBA00025646", "url": "https://www.uniprot.org/uniprotkb/ARBA00025646#function" }, { "database": "UniProtKB", "id": "A0A3Q1M2B4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B4#function" }, { "database": "UniProtKB", "id": "F1MB94", "url": "https://www.uniprot.org/uniprotkb/F1MB94#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MB94", "url": "https://www.uniprot.org/uniprotkb/F1MB94" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRFBP1", "url": "https://www.uniprot.org/uniprotkb/F1MB94", "locus": { "chromosome": "7", "start_pos": 31794203, "end_pos": 31855108, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014320", "url": "https://www.ensembl.org/id/ENSBTAG00000014320" } ] } } ], "crossref": [ { "id": "F1MB94", "url": "https://alphafold.ebi.ac.uk/entry/F1MB94", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014320", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014320", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR015158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037393", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037393", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GFQQNEP", "url": "https://omabrowser.org/oma/group/GFQQNEP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23325", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23325", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23325:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23325:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09073", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09073", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M2B4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2B4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU87-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB94", "url": "https://www.uniprot.org/uniprotkb/F1MB94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB94-1", "url": "https://www.uniprot.org/uniprotkb/F1MB94-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "YVVKMRKEVKRIRVLVIRKLVRSVGRLKSKKGSEDALLKNQRRAQRLLEEIRAMKELKPDVVTKSALGEDINFEKICKKPDSTAAERAIARLAVHPLLKKKIDVLKAAVKSFKDARQNVVEVKSSNSASEENHSKDTLCSNDDASKLQHEGTIIREQKEKEAKILAKKPINNSKEKIAKMDHGPKAMDVPNSLSKPSGKDSPASSASQKTPSDPKMKALSKTKKMKESSSSLDVDSDGEELYEEEKEYFDDSTEERFYKQSSMSEDSDSGDDFFIGKVKRARKKESSCRFSDKEQNPPKNLLLEEGILETHQNLQNDKNKPRTEARRFESVFFQSLSGSKSLERNHREQVPRSKTMDFQHIEPQNKNQFNKKAQRGFENTKQKSQLPLHPSWEASRRRKEQQSKIAVFQGKKITFDD", "length": 417, "header": "tr|F1MB94-1|F1MB94_BOVIN Isoform 1 of Serum response factor-binding protein 1 OS=Bos taurus OX=9913 GN=SRFBP1 PE=4 SV=3 CANONICAL=F1MB94-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M2B4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2B4/entry", "sequence": { "sequence": "MRGSEDALLKNQRRAQRLLEEIRAMKELKPDVVTKSALGEDINFEKICKKPDSTAAERAIARLAVHPLLKKKIDVLKAAVKSFKDARQNVVEVKSSNSASEENHSKDTLCSNDDASKLQHEGTIIREQKEKEAKILAKKPINNSKEKIAKMDHGPKAMDVPNSLSKPSGKDSPASSASQKTPSDPKMKALSKTKKMKESSSSLDVDSDGEELYEEEKEYFDDSTEERFYKQSSMSEDSDSGDDFFIGKVKRARKKESSCRFSDKEQNPPKNLLLEEGILETHQNLQNDKNKPRTEARRFESVFFQSLSGSKSLERNHREQVPRSKTMDFQHIEPQNKNQFNKKAQRGFENTKQKSQLPLHPSWEASRRRKEQQSKIAVFQGKKITFDD", "length": 388, "header": "tr|A0A3Q1M2B4-1|F1MB94_BOVIN Computationally mapped isoform of Serum response factor-binding protein 1 OS=Bos taurus OX=9913 GN=SRFBP1 PE=4 SV=2 CANONICAL=F1MB94-1" }, "locus": { "chromosome": "7", "start_pos": 31854587, "end_pos": 31794301, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087503.2", "url": "https://www.ensembl.org/id/ENSBTAT00000087503.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063913.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063913.2" } ] } }, { "isoform_ac": "A0AAA9SU87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU87/entry", "sequence": { "sequence": "MAEPETLNLNNEVVKMRKEVKRIRVLVIRKLVRSVGRLKSKKGSEDALLKNQRRAQRLLEEIRAMKELKPDVVTKSALGEDINFEKICKKPDSTAAERAIARLAVHPLLKKKIDVLKAAVKSFKDARQNVVEVKSSNSASEENHSKDTLCSNDDASKLQHEGTIIREQKEKEAKILAKKPINNSKEKIAKMDHGPKAMDVPNSLSKPSGKDSPASSASQKTPSDPKMKALSKTKKMKESSSSLDVDSDGEELYEEEKEYFDDSTEERFYKQSSMSEDSDSGDDFFIGKVKRARKKESSCRFSDKEQNPPKNLLLEEGILETHQNLQNDKNKPRTEARRFESVFFQSLSGSKSLERNHREQVPRSKTMDFQHIEPQNKNQFNKKAQRGFENTKQKSQLPLHPSWEASRRRKEQQSKIAVFQGKKITFDD", "length": 428, "header": "tr|A0AAA9SU87-1|F1MB94_BOVIN Computationally mapped isoform of Serum response factor-binding protein 1 OS=Bos taurus OX=9913 GN=SRFBP1 PE=4 SV=1 CANONICAL=F1MB94-1" }, "locus": { "chromosome": "7", "start_pos": 31854618, "end_pos": 31794301, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130814.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130814.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089995.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089995.1" } ] } }, { "isoform_ac": "F1MB94-1", "url": "https://www.uniprot.org/uniprotkb/F1MB94/entry", "sequence": { "sequence": "YVVKMRKEVKRIRVLVIRKLVRSVGRLKSKKGSEDALLKNQRRAQRLLEEIRAMKELKPDVVTKSALGEDINFEKICKKPDSTAAERAIARLAVHPLLKKKIDVLKAAVKSFKDARQNVVEVKSSNSASEENHSKDTLCSNDDASKLQHEGTIIREQKEKEAKILAKKPINNSKEKIAKMDHGPKAMDVPNSLSKPSGKDSPASSASQKTPSDPKMKALSKTKKMKESSSSLDVDSDGEELYEEEKEYFDDSTEERFYKQSSMSEDSDSGDDFFIGKVKRARKKESSCRFSDKEQNPPKNLLLEEGILETHQNLQNDKNKPRTEARRFESVFFQSLSGSKSLERNHREQVPRSKTMDFQHIEPQNKNQFNKKAQRGFENTKQKSQLPLHPSWEASRRRKEQQSKIAVFQGKKITFDD", "length": 417, "header": "tr|F1MB94-1|F1MB94_BOVIN Isoform 1 of Serum response factor-binding protein 1 OS=Bos taurus OX=9913 GN=SRFBP1 PE=4 SV=3 CANONICAL=F1MB94-1" }, "locus": { "chromosome": "7", "start_pos": 31842370, "end_pos": 31794301, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053358.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053358.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049639.3", "url": "https://www.ensembl.org/id/ENSBTAP00000049639.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0X7V0-1", "protein_name": "Serum response factor-binding protein 1", "gene_name": "SRFBP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKYVSPLKGKYWSSGAFTLKKFFLQVVKMRKDVKKARVLTIRRLTRHIGKLKLKKGSEDLKLKNQKRVERLIEEIHAMKEIKPDQVTRLALRKEVNFESVCRKPKSTASERAIARLATHPLLKPKIAELKAAVKAFKDARQNPAKANPSEKKSEVQPKSAQNSNSNLNGQVLKLVQKQQGFGDRTKPSVKMETVGGADKVSEGEPEQEIMEMERIPKEFSPQSIEMQAVTQTGKKLGCKKRKENVSMNKLTAVKQIVRDDSDLEQQSEEEYFDDSTEERFYNQTSNSDSDSNDDFFIGKVKRKKKTAAASDLFSVEEKNTLQKNIPKEEKSTVSGTVQNLVMEGKPHGKARKLESVFCTSLSTCNQKSQNRRNTKDQPLTNRQTALHKKEPQLKKQSFAKASILKRDGKNPRLEQPLHPSWEASRRRREQMSQITAFQGKKIKFDD", "length": 446 }, "evidence": [ { "id": "F1MB94", "url": "https://omabrowser.org/oma/group/F1MB94/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q66H19-1", "protein_name": "Serum response factor-binding protein 1", "gene_name": "Srfbp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAADPSPPSAMAQPRPLNLNNEVVKMRKEVKRIRVLVIRKLVRSVSRLKSKKGSEDALLKNQRRAQRLLQEIHAMKELKPDVITKSALNDDINFEKTCKKPDSTATERAIARLAVHPLLKRKVDALKAAIQAFKDARQNAPEAESSKSASKESQCEDIPRSQAEASESQHPERTVVGEQKGKDKDPTTAKKAGSGSKEKLAKGKQGPKAVATPHSPGKPSEKGAGINSERQGAPTPGNHSQGKASTRTTEDSVCEPDDNSISKEEVSEEEKEYFDDSTEERFYKQSSASEDSDSGDDFFIGKVRRTRKKECAVPSSAKEQKPLPKVSSKTNTLETHWDIRNDKHKLIPEARKLESVFFHSLSGPKSSRRDPREQAPKNKAPDIPENEPPIQNKFTKSARRGFESAKQPSYAPLHPSWEASRRRKEQQSKIAVFQGKKITFDD", "length": 442 }, "evidence": [ { "id": "F1MB94", "url": "https://omabrowser.org/oma/group/F1MB94/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NEF9-1", "protein_name": "Serum response factor-binding protein 1", "gene_name": "SRFBP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQPGTLNLNNEVVKMRKEVKRIRVLVIRKLVRSVGRLKSKKGTEDALLKNQRRAQRLLEEIHAMKELKPDIVTKSALGDDINFEKIFKKPDSTATERAIARLAVHPLLKKKIDVLKAAVQAFKEARQNVAEVESSKNASEDNHSENTLYSNDNGSNLQREATVISEQKVKETKILAKKPIHNSKEKIAKMEHGPKAVTIANSPSKPSEKDSVVSLESQKTPADPKLKTLSQTKKNKGSDSSLSGNSDGGEEFCEEEKEYFDDSTEERFYKQSSMSEDSDSGDDFFIGKVRRTRKKESSCHSSVKEQKPLEKVFLKEDTGETHGDTRNDKIKPSTETRKLESVFFHSLSGSKSSRRNFKEQAPKTRSLDFPQNEPQIKNQFNKKLSGRLENTKQQLQLPLHPSWEASRRRKEQQSNIAVFQGKKITFDD", "length": 429 }, "evidence": [ { "id": "F1MB94", "url": "https://omabrowser.org/oma/group/F1MB94/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CZ91-1", "protein_name": "Serum response factor-binding protein 1", "gene_name": "Srfbp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAADPLPPSAMVQPGTLNLNNEVVKMRKEVKRIRVLVIRKLVRSVGRLKSKKGTEDALLKNQRRAQRLLEEIHAMKELKPDVVTKSALSDDINFEKTCKKPDSTATDRAVARLAGHPLLKKKIDVLKDAVQAFKDARQSAPAAESSESTSGEGRCKDIARSKDDARESQHPERTVVREQKAKDTNTAAKNAASGSKEKLAKTEQAPRAGTTPGSQGRPSGKGAGVNSEHQGAPAPGDSNQGKASTKTPEDSVCEPANNGVSEEEESEGEKEYFDDSTEERFYKQSSASEDSDSGDDFFIGKVRRTRKKESGVHSSAKELKPLPKVPSKTSTLETPWDVRNDKHRPIPEARKFESVFFHSLAGPKSSRRDPREQAPKNKAPDFPENEPPVKKQFTKSAYRGFESVKQTMQAPLHPSWEASRRRKEQQSKIAVFQGKKITFDD", "length": 441 }, "evidence": [ { "id": "F1MB94", "url": "https://omabrowser.org/oma/group/F1MB94/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MB94", "url": "https://www.uniprot.org/uniprotkb/F1MB94" } ], "pmid": "" }, { "name": "90S preribosome", "id": "GO:0030686", "url": 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"database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09073" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Bud22", "eco_id": "ECO_0000259", "start_pos": 319, "end_pos": 416, "start_aa": "Asn", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 132, "end_pos": 134 }, { "start_pos": 171, "end_pos": 173 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"https://www.uniprot.org/uniprotkb/F1MDN4#function" }, { "database": "UniProtKB", "id": "PIRNR039087", "url": "https://www.uniprot.org/uniprotkb/PIRNR039087#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MDN4", "url": "https://www.uniprot.org/uniprotkb/F1MDN4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RPLP0", "url": "https://www.uniprot.org/uniprotkb/F1MDN4", "locus": { "chromosome": "17", "start_pos": 62557772, "end_pos": 62561808, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017389", "url": "https://www.ensembl.org/id/ENSBTAG00000017389" } ] } } ], "crossref": [ { "id": "F1MDN4", "url": "https://alphafold.ebi.ac.uk/entry/F1MDN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017389", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017389", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05795", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05795", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030670", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030670", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040637", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040637", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043141", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043141", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050323", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050323", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DMNPFKL", "url": "https://omabrowser.org/oma/group/DMNPFKL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MDN4", "url": "https://www.orthodb.org/?gene=F1MDN4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45699", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45699", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45699:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45699:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00428", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00428", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00466", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00466", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17777", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17777", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-156827", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72689", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72706", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975956", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954714", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9954716", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T0W1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0W1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TK96", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TK96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDN4", "url": "https://www.uniprot.org/uniprotkb/F1MDN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDN4-1", "url": "https://www.uniprot.org/uniprotkb/F1MDN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLVIQQVFDNGSIYNPEVLDITEETLHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAAPTAAPAATTAAPAKVEAKEESEESDEDMGFGLFD", "length": 318, "header": "tr|F1MDN4-1|F1MDN4_BOVIN Isoform 1 of 60S acidic ribosomal protein P0 OS=Bos taurus OX=9913 GN=RPLP0 PE=3 SV=2 CANONICAL=F1MDN4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T0W1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0W1/entry", "sequence": { "sequence": "RNVSLPQGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAAPTAAPAATTAAPAKVEAKEESEESDEDMGFGLFD", "length": 108, "header": "tr|A0AAA9T0W1-1|F1MDN4_BOVIN Computationally mapped isoform of 60S acidic ribosomal protein P0 OS=Bos taurus OX=9913 GN=RPLP0 PE=3 SV=1 CANONICAL=F1MDN4-1" }, "locus": { "chromosome": "17", "start_pos": 62558746, "end_pos": 62557843, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127980.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127980.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089283.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089283.1" } ] } }, { "isoform_ac": "A0AAA9TK96-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK96/entry", "sequence": { "sequence": "MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAAPTAAPAATTAAPAKVEAKEESEESDEDMGFGLFD", "length": 256, "header": "tr|A0AAA9TK96-1|F1MDN4_BOVIN Computationally mapped isoform of 60S acidic ribosomal protein P0 OS=Bos taurus OX=9913 GN=RPLP0 PE=3 SV=1 CANONICAL=F1MDN4-1" }, "locus": { "chromosome": "17", "start_pos": 62561487, "end_pos": 62557843, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105774.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105774.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097622.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097622.1" } ] } }, { "isoform_ac": "F1MDN4-1", "url": "https://www.uniprot.org/uniprotkb/F1MDN4/entry", "sequence": { "sequence": "MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLVIQQVFDNGSIYNPEVLDITEETLHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAAPTAAPAATTAAPAKVEAKEESEESDEDMGFGLFD", "length": 318, "header": "tr|F1MDN4-1|F1MDN4_BOVIN Isoform 1 of 60S acidic ribosomal protein P0 OS=Bos taurus OX=9913 GN=RPLP0 PE=3 SV=2 CANONICAL=F1MDN4-1" }, "locus": { "chromosome": "17", "start_pos": 62561487, "end_pos": 62557843, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055086.3", "url": "https://www.ensembl.org/id/ENSBTAT00000055086.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048183.2", "url": "https://www.ensembl.org/id/ENSBTAP00000048183.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 286, "start_aa": "Thr", "end_pos": 286, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr286", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-156827", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156827", "resource": "Reactome", "description": "L13a-mediated translational silencing of Ceruloplasmin expression" }, { "id": "R-BTA-1799339", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" }, { "id": "R-BTA-72689", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72689", "resource": "Reactome", "description": "Formation of a pool of free 40S subunits" }, { "id": "R-BTA-72706", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72706", "resource": "Reactome", "description": "GTP hydrolysis and joining of the 60S ribosomal subunit" }, { "id": "R-BTA-975956", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975956", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" }, { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" }, { "id": "R-BTA-9954709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954709", "resource": "Reactome", "description": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide" }, { "id": "R-BTA-9954714", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954714", "resource": "Reactome", "description": "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA" }, { "id": "R-BTA-9954716", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9954716", "resource": "Reactome", "description": "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "P05317-1", "protein_name": "Large ribosomal subunit protein uL10", "gene_name": "RPP0", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MGGIREKKAEYFAKLREYLEEYKSLFVVGVDNVSSQQMHEVRKELRGRAVVLMGKNTMVRRAIRGFLSDLPDFEKLLPFVKGNVGFVFTNEPLTEIKNVIVSNRVAAPARAGAVAPEDIWVRAVNTGMEPGKTSFFQALGVPTKIARGTIEIVSDVKVVDAGNKVGQSEASLLNLLNISPFTFGLTVVQVYDNGQVFPSSILDITDEELVSHFVSAVSTIASISLAIGYPTLPSVGHTLINNYKDLLAVAIAASYHYPEIEDLVDRIENPEKYAAAAPAATSAASGDAAPAEEAAAEEEEESDDDMGFGLFD", "length": 312 }, "evidence": [ { "id": "F1MDN4", "url": "https://omabrowser.org/oma/group/F1MDN4/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P05388-1", "protein_name": "Large ribosomal subunit protein uL10", "gene_name": "RPLP0", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLVIQQVFDNGSIYNPEVLDITEETLHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAKEESEESDEDMGFGLFD", "length": 317 }, "evidence": [ { "id": "F1MDN4", "url": "https://omabrowser.org/oma/group/F1MDN4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P14869-1", "protein_name": "Large ribosomal subunit protein uL10", "gene_name": "Rplp0", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLIIQQVFDNGSIYSPEVLDITEQALHTRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFAAAAPVAAATTAAPAAAAAPAKVEAKEESEESDEDMGFGLFD", "length": 317 }, "evidence": [ { "id": "F1MDN4", "url": "https://omabrowser.org/oma/group/F1MDN4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P22685-1", "protein_name": "Large ribosomal subunit protein uL10", "gene_name": "rplp0", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSGAGSKRKNVFIEKATKLFTTYDKMIVAEADFVGSSQLQKIRKSIRGIGAVLMGKKTMIRKVIRDLADSKPELDALNTYLKQNTCIIFCKDNIAEVKRVINTQRVGAPAKAGVFAPNDVIIPAGPTGMEPTQTSFLQDLKIATKINRGQIDIVNEVHIIKTGQKVGASEATLLQKLNIKPFTYGLEPKIIYDAGACYSPSISEEDLINKFKQGIFNIAAISLEIGYPTVASIPHSVMNAFKNLLAISFETSYTFDAAEKFKSAAAAAPVAAAPSAAAPAAAAKKVVVEEKKEESDDDMGMGLFD", "length": 305 }, "evidence": [ { "id": "F1MDN4", "url": "https://omabrowser.org/oma/group/F1MDN4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "P47826-1", "protein_name": "Large ribosomal subunit protein uL10", "gene_name": "RPLP0", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPREDRATWKSNYFMKIIQLLDDYPKCFVVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCDVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLVIQQVFDNGSIYNPEVLDITEETLHKRFLEGVRNVASVCLQIGYPTIASVPHSIVNGYKRVLAVAVETDYTFPLAEKVKAFLADPSAFVAAAPVVVETAAPAAAAAPAKEAPKEESEESDEDMGFGLFD", "length": 316 }, "evidence": [ { "id": "F1MDN4", "url": "https://omabrowser.org/oma/group/F1MDN4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q29214-1", "protein_name": "Large ribosomal subunit protein uL10", "gene_name": "RPLP0", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPREDRATWKSNYFLKIIQLLDDYPKCFIVGADNVGSKQMQQIRMSLRGKAVVLMGKNTMMRKAIRGHLENNPALEKLLPHIRGNVGFVFTKEDLTEIRDMLLANKVPAAARAGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTKISRGTIEILSDVQLIKTGDKVGASEATLLNMLNISPFSFGLIIQQVFDNGSIYNPEVLDITEETLHSRFLEGVRNVASVCLQIGYPTVASVPHSIINGYKRVLALSVETDYTFPLAEKVKAFLADPSAFVAAAPVAAATTAAPAAAAAAPAKVEAKEESEESDEDMGFGLFD", "length": 318 }, "evidence": [ { "id": "F1MDN4", "url": "https://omabrowser.org/oma/group/F1MDN4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q42112-1", "protein_name": "Large ribosomal subunit protein uL10y", "gene_name": "RPP0B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVKATKAEKKIAYDTKLCQLIDEYTQILVVAADNVGSTQLQNIRKGLRGDSVVLMGKNTMMKRSVRIHSENTGNTAILNLLPLLQGNVGLIFTKGDLKEVSEEVAKYKVGAPARVGLVAPIDVVVQPGNTGLDPSQTSFFQVLNIPTKINKGTVEIITPVELIKQGDKVGSSEAALLAKLGIRPFSYGLVVQSVYDNGSVFSPEVLDLTEDQLVEKFASGISMVTSLALAVSYPTLAAAPHMFINAYKNALAIAVATEYTFPQAEKVKEYLKDPSKFAVASVAAVSADAGGGAPAAAKVEEKEESDEEDYGGDFGLFDEE", "length": 320 }, "evidence": [ { "id": "F1MDN4", "url": "https://omabrowser.org/oma/group/F1MDN4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "F1MDN4", "url": "https://www.uniprot.org/uniprotkb/F1MDN4" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "F1MDN4", "url": "https://www.uniprot.org/uniprotkb/F1MDN4" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MDN4", "url": "https://www.uniprot.org/uniprotkb/F1MDN4" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "F1MDN4", "url": "https://www.uniprot.org/uniprotkb/F1MDN4" } ], "pmid": "" }, { "name": "cytoplasmic ribonucleoprotein granule", "id": "GO:0036464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036464", "evidence": [ { "database": "UniProtKB", "id": "F1MDN4", "url": "https://www.uniprot.org/uniprotkb/F1MDN4" } ], "pmid": "" }, { "name": "cytosolic large ribosomal subunit", "id": "GO:0022625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022625", "evidence": [ { "database": "UniProtKB", "id": "F1MDN4", "url": "https://www.uniprot.org/uniprotkb/F1MDN4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "ribosome biogenesis", "id": "GO:0042254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042254", "evidence": [ { "database": "UniProtKB", "id": "F1MDN4", "url": "https://www.uniprot.org/uniprotkb/F1MDN4" } ], "pmid": "" }, { "name": "cytoplasmic translation", "id": "GO:0002181", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002181", "evidence": [ { "database": "UniProtKB", "id": "F1MDN4", "url": "https://www.uniprot.org/uniprotkb/F1MDN4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "structural constituent of ribosome", "id": "GO:0003735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003735", "evidence": [ { "database": "UniProtKB", "id": "F1MDN4", "url": "https://www.uniprot.org/uniprotkb/F1MDN4" } ], "pmid": "" }, { "name": "large ribosomal subunit rRNA binding", "id": "GO:0070180", "url": 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"PF17777", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17777" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Large ribosomal subunit protein uL10-like insertion", "eco_id": "ECO_0000259", "start_pos": 111, "end_pos": 180, "start_aa": "Ala", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 286 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 179, "end_pos": 181 }, { "start_pos": 195, "end_pos": 197 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { 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}, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPL6-1", "uniprot_ac": "E1BPL6", "uniprot_id": "E1BPL6_BOVIN", "mass": { "chemical_mass": 57780.0, "monoisotopic_mass": 57780.0 }, "refseq": { "ac": "NP_001193004", "name": "REST corepressor 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193004" }, "gene_names": [ { "name": "RCOR2", "type": "recommended", "evidence": [ { "id": "E1BPL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPL6" } ] }, { "name": "RCOR2", "type": "synonym", "evidence": [ { "id": "NP_001193004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193004" } ] } ], "protein_names": [ { "name": "REST corepressor 2", "type": "recommended", "evidence": [ { "id": "E1BPL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPL6/entry#names_and_taxonomy" } ] }, { "name": "REST corepressor 2", "type": "synonym", "evidence": [ { "id": "NP_001193004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193004" } ] } ], "function": [ { "annotation": "May act as a component of a corepressor complex that represses transcription.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T1H5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1H5#function" }, { "database": "UniProtKB", "id": "ARBA00037180", "url": "https://www.uniprot.org/uniprotkb/ARBA00037180#function" }, { "database": "UniProtKB", "id": "E1BPL6", "url": "https://www.uniprot.org/uniprotkb/E1BPL6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPL6", "url": "https://www.uniprot.org/uniprotkb/E1BPL6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RCOR2", "url": "https://www.uniprot.org/uniprotkb/E1BPL6", "locus": { "chromosome": "29", "start_pos": 42253218, "end_pos": 42258511, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007827", "url": "https://www.ensembl.org/id/ENSBTAG00000007827" } ] } } ], "crossref": [ { "id": "E1BPL6", "url": "https://alphafold.ebi.ac.uk/entry/E1BPL6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007827", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007827", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00167", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00167", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "541233", "url": "https://www.ncbi.nlm.nih.gov/gene/541233", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000949", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000949", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:541233", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541233", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CIKQINS", "url": "https://omabrowser.org/oma/group/CIKQINS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPL6", "url": "https://www.orthodb.org/?gene=E1BPL6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16089", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16089", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16089:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16089:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00249", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00249", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01448", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01448", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20878", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20878", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193004", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T1H5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1H5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1H5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1H5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPL6", "url": "https://www.uniprot.org/uniprotkb/E1BPL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPL6-1", "url": "https://www.uniprot.org/uniprotkb/E1BPL6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSVMEKPSAGSGILSRSRAKTAPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDDLEEGRGAVSEGEPDAGDPKREPLPSRPLNTRPGPGKKEAQGSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDGAPGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSGPRSGPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAASRHSARPGPQPPPTLIGAPLEPPAPSL", "length": 523, "header": "tr|E1BPL6-1|E1BPL6_BOVIN Isoform 1 of REST corepressor 2 OS=Bos taurus OX=9913 GN=RCOR2 PE=3 SV=1 CANONICAL=E1BPL6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1H5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1H5/entry", "sequence": { "sequence": "MPSVMEKPSAGSGILSRSRAKTAPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDDLEEGRGAVSEGEPDAGDPKREPLPSRPLNTRPGPGKKEAQGSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQGPDYIRLHVGTPIGAPCAAPSSTSHLAVPAAPTAEATLAHCPHPASPATPTPAGPFPSAPAGPQPATTTSHPPCPGCIPPQCPPWPSAPTHLDWSPSGASGTLALSAEALRQPEAPEALGWASLGTSSFKPRTEGTRGRARSFEDPGLPRRAQLAPWILHVVSGGQAWPGSGAL", "length": 516, "header": "tr|A0AAA9T1H5-1|E1BPL6_BOVIN Computationally mapped isoform of REST corepressor 2 OS=Bos taurus OX=9913 GN=RCOR2 PE=3 SV=1 CANONICAL=E1BPL6-1" }, "locus": { "chromosome": "29", "start_pos": 42258312, "end_pos": 42254222, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121616.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121616.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090428.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090428.1" } ] } }, { "isoform_ac": "E1BPL6-1", "url": "https://www.uniprot.org/uniprotkb/E1BPL6/entry", "sequence": { "sequence": "MPSVMEKPSAGSGILSRSRAKTAPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDDLEEGRGAVSEGEPDAGDPKREPLPSRPLNTRPGPGKKEAQGSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDGAPGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSGPRSGPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAASRHSARPGPQPPPTLIGAPLEPPAPSL", "length": 523, "header": "tr|E1BPL6-1|E1BPL6_BOVIN Isoform 1 of REST corepressor 2 OS=Bos taurus OX=9913 GN=RCOR2 PE=3 SV=1 CANONICAL=E1BPL6-1" }, "locus": { "chromosome": "29", "start_pos": 42258312, "end_pos": 42254431, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010294.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010294.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010294.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010294.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:541233", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:541233", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5FWT8-1", "protein_name": "REST corepressor 2", "gene_name": "Rcor2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSVMEKPSAGSGILSRSRAKTAPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDELEEGRGAVSEGEPDTGDPKREPLPSRPLNARPGPGKKEIQVSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDGAPTAPVPVEEARRGAPVPATALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAASRHSARPGPQPPPTLVGAQLEPPAPSL", "length": 523 }, "evidence": [ { "id": "E1BPL6", "url": "https://omabrowser.org/oma/group/E1BPL6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8C796-1", "protein_name": "REST corepressor 2", "gene_name": "Rcor2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPSVMEKPSAGSGILSRSRAKTAPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKVIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDELEEGRGAVSEGEPDTGDPKREPLPSRPLNARPGPGKKEVQISQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDGAPAAPVPTEEARRGAPVPATALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAASRHSARPGPQPPPTLVGAPLEPPAPSL", "length": 523 }, "evidence": [ { "id": "E1BPL6", "url": "https://omabrowser.org/oma/group/E1BPL6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IZ40-1", "protein_name": "REST corepressor 2", "gene_name": "RCOR2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSVMEKPSAGSGILSRSRAKTVPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDELEEGRGGVSEGEPDPADPKREPLPSRPLNARPGPGKKEVQVSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDGAPGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAAPRHSARPGPQPPPTLIGTPLEPPAPSL", "length": 523 }, "evidence": [ { "id": "E1BPL6", "url": "https://omabrowser.org/oma/group/E1BPL6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BPL6", "url": "https://www.uniprot.org/uniprotkb/E1BPL6" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "E1BPL6", "url": "https://www.uniprot.org/uniprotkb/E1BPL6" } ], "pmid": "" }, { "name": "histone deacetylase complex", "id": "GO:0000118", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000118", "evidence": [ { "database": "UniProtKB", "id": "E1BPL6", "url": "https://www.uniprot.org/uniprotkb/E1BPL6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BPL6", "url": "https://www.uniprot.org/uniprotkb/E1BPL6" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BPL6", "url": "https://www.uniprot.org/uniprotkb/E1BPL6" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "E1BPL6", "url": "https://www.uniprot.org/uniprotkb/E1BPL6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "E1BPL6", "url": "https://www.uniprot.org/uniprotkb/E1BPL6" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "E1BPL6", "url": "https://www.uniprot.org/uniprotkb/E1BPL6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 281, "end_pos": 283, "annotation": "n_glycosylation_sequon" }, { "start_pos": 305, "end_pos": 307, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPL6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 523, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPL6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPL6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPL6" }, { "id": "PS51156", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51156" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ELM2", "eco_id": "ECO_0000259", "start_pos": 44, "end_pos": 129, "start_aa": "Ser", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BPL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPL6" }, { "id": "PS51293", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51293" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SANT", "eco_id": "ECO_0000259", "start_pos": 130, "end_pos": 181, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 127, "end_pos": 129 }, { "start_pos": 281, "end_pos": 283 }, { "start_pos": 305, "end_pos": 307 }, { "start_pos": 360, "end_pos": 362 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MBS0-1", "uniprot_ac": "F1MBS0", "uniprot_id": "F1MBS0_BOVIN", "mass": { "chemical_mass": 36940.0, "monoisotopic_mass": 36940.0 }, "refseq": { "ac": "XP_059731193", "name": "carbonic anhydrase 6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731193" }, "gene_names": [ { "name": "CA6", "type": "recommended", "evidence": [ { "id": "F1MBS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBS0" } ] }, { "name": "CA6", "type": "synonym", "evidence": [ { "id": "XP_059731193", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731193" } ] } ], "protein_names": [ { "name": "Carbonic anhydrase", "type": "recommended", "evidence": [ { "id": "F1MBS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBS0/entry#names_and_taxonomy" } ] }, { "name": "4.2.1.1", "type": "synonym", "evidence": [ { "id": "F1MBS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBS0/entry#names_and_taxonomy" } ] }, { "name": "carbonic anhydrase 6 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059731193", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731193" } ] } ], "function": [ { "annotation": "Reversible hydration of carbon dioxide. Its role in saliva is unknown.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TFU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU6#function" }, { "database": "UniProtKB", "id": "ARBA00025355", "url": "https://www.uniprot.org/uniprotkb/ARBA00025355#function" }, { "database": "UniProtKB", "id": "F1MBS0", "url": "https://www.uniprot.org/uniprotkb/F1MBS0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MBS0", "url": "https://www.uniprot.org/uniprotkb/F1MBS0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CA6", "url": "https://www.uniprot.org/uniprotkb/F1MBS0", "locus": { "chromosome": "16", "start_pos": 44440385, "end_pos": 44465148, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009515", "url": "https://www.ensembl.org/id/ENSBTAG00000009515" } ] } } ], "crossref": [ { "id": "F1MBS0", "url": "https://alphafold.ebi.ac.uk/entry/F1MBS0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009515", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009515", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "280742", "url": "https://www.ncbi.nlm.nih.gov/gene/280742", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PMINNGH", "url": "https://omabrowser.org/oma/group/PMINNGH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MBS0", "url": "https://www.orthodb.org/?gene=F1MBS0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18952", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18952", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18952:SF110", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18952:SF110", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00194", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00194", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1475029", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1475029", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059731193", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731193", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10748", "url": "https://www.rhea-db.org/rhea/10748", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TFU6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBS0", "url": "https://www.uniprot.org/uniprotkb/F1MBS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBS0-1", "url": "https://www.uniprot.org/uniprotkb/F1MBS0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MITLLFLLVVGAQAQHEWTYSEGVLDEKHWRLQYPDCGGTRQSPIDLKMKKVRYNPSLRALNLTGYGLRQGEFPMTNNGHTVQISLPSSMRMTTSDGSQYLAKQMHFHWGGASSEISGSEHTVDGMRYIIEIHVVHYNSKYGSYEEAQNEPDGLAVLAALVEVKDYAENTYYSNFISHLEDIRYAGQSTVLRDLDIQDMLPGDLRYYYSYLGSLTTPSCTENVHWFVVADTVKLSKTQIEKLENSLLNHQNETIQNNYRSTQPLNHRVVEANFVSHPHQEYTLGSKLHFYLNNIDQNLEYLRRFIEQKITKRKKEKYWP", "length": 319, "header": "tr|F1MBS0-1|F1MBS0_BOVIN Isoform 1 of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA6 PE=3 SV=1 CANONICAL=F1MBS0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TFU6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU6/entry", "sequence": { "sequence": "MITLLFLLVVGAQAQHEWTYSEGVLDEKHWRLQYPDCGGTRQSPIDLKMKKVRYNPSLRALNLTGYGLRQGEFPMTNNGHTVQISLPSSMRMTTSDGSQYLAKQMHFHWGGASSEISGSEHTVDGMRYIIEIHVVHYNSKYGSYEEAQNEPDGLAVLAALVEVKDYAENTYYSNFISHLEDIRYAGQSTVLRDLDIQDMLPGDLRYYYSYLGSLTTPSCTENVHWFVVADTVKLSKTQIEKLENSLLNHQNETIQNNYRSTQPLNHRVVEANFVSHPHQGKGYLHMKQGSRVEPSLTCHPLDSGSLQA", "length": 308, "header": "tr|A0AAA9TFU6-1|F1MBS0_BOVIN Computationally mapped isoform of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA6 PE=3 SV=1 CANONICAL=F1MBS0-1" }, "locus": { "chromosome": "16", "start_pos": 44465082, "end_pos": 44440989, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121854.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121854.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097036.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097036.1" } ] } }, { "isoform_ac": "F1MBS0-1", "url": "https://www.uniprot.org/uniprotkb/F1MBS0/entry", "sequence": { "sequence": "MITLLFLLVVGAQAQHEWTYSEGVLDEKHWRLQYPDCGGTRQSPIDLKMKKVRYNPSLRALNLTGYGLRQGEFPMTNNGHTVQISLPSSMRMTTSDGSQYLAKQMHFHWGGASSEISGSEHTVDGMRYIIEIHVVHYNSKYGSYEEAQNEPDGLAVLAALVEVKDYAENTYYSNFISHLEDIRYAGQSTVLRDLDIQDMLPGDLRYYYSYLGSLTTPSCTENVHWFVVADTVKLSKTQIEKLENSLLNHQNETIQNNYRSTQPLNHRVVEANFVSHPHQEYTLGSKLHFYLNNIDQNLEYLRRFIEQKITKRKKEKYWP", "length": 319, "header": "tr|F1MBS0-1|F1MBS0_BOVIN Isoform 1 of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA6 PE=3 SV=1 CANONICAL=F1MBS0-1" }, "locus": { "chromosome": "16", "start_pos": 44465082, "end_pos": 44440685, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012525.4", "url": "https://www.ensembl.org/id/ENSBTAT00000012525.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012525.2", "url": "https://www.ensembl.org/id/ENSBTAP00000012525.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-1475029", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1475029", "resource": "Reactome", "description": "Reversible hydration of carbon dioxide" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LQ08-1", "protein_name": "Carbonic anhydrase", "gene_name": "Ca6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRVLVSVVSLFFLGIQALSEWSYSGDDGLEESRWPEKYPSCGGERQSPIDVKRREVHFSSSLLPLHMVNYEEEGLELSMTNNGHTVQITLPNTMSMRDSDGTVYRTKQMHFHWGGRDSEISGSEHTIDGMRHAIEIHLVHFNEKYETYEKAVDQPDGLAVMAVLVKVEDYTENDYYSTFISELENVKYTGQTTTLRNVNIRNMLPGDIRHYYTYQGSLTTPPCTENVKWFVFQDSATISKAQAERIENAVMDHHNQTIRNGYRRTQPLHNRVVEANFPYSPDEVSKNHFYMHEKISHGLKLKKIKKKRNHSH", "length": 312 }, "evidence": [ { "id": "F1MBS0", "url": "https://omabrowser.org/oma/group/F1MBS0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RIH8-1", "protein_name": "Carbonic anhydrase", "gene_name": "CA6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTALVTLLFLLLLGAQTQHGAEWTYSDGELDEAHWSREYPDCDGRRQSPIDVQRKSVQYNPALRALSLTGYEAQEGEFSMINNGHTVQISLPSTMRLTAPDGTQYIAKQMHFHWGGAFSEISGSEHTIDGIRYVTEVHVVHYNSKYKSYDEAQTAPDGLAVLAALFEIKDYAENTYYSDFISHLKNIRNPGQTTVLSSLNLQDMLPENLHSYYSYQGSLTTPPCTENVHWFVLADTVKLSRTQVWKLQNSLLNDQNKTIHNDYRRTQPLNHRVVEANFKSLPNPRSELHFYLNNIDNNLEYLRRVIEQKKAKGKGPW", "length": 317 }, "evidence": [ { "id": "F1MBS0", "url": "https://omabrowser.org/oma/group/F1MBS0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P23280-1", "protein_name": "Carbonic anhydrase 6", "gene_name": "CA6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEILDYLRRALN", "length": 308 }, "evidence": [ { "id": "F1MBS0", "url": "https://omabrowser.org/oma/group/F1MBS0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MBS0", "url": "https://www.uniprot.org/uniprotkb/F1MBS0" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1MBS0", "url": "https://www.uniprot.org/uniprotkb/F1MBS0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MBS0", "url": "https://www.uniprot.org/uniprotkb/F1MBS0" } ], "pmid": "" }, { "name": "carbonate dehydratase activity", "id": "GO:0004089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004089", "evidence": [ { "database": "UniProtKB", "id": "F1MBS0", "url": "https://www.uniprot.org/uniprotkb/F1MBS0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of bitter taste", "id": "GO:0001580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001580", "evidence": [ { "database": "UniProtKB", "id": "F1MBS0", "url": "https://www.uniprot.org/uniprotkb/F1MBS0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10748", "name": "", "equation": "hydrogencarbonate + H(+) = CO2 + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N5D1-1", "G3MX64-1", "E1BAD9-1", "E1BHA4-1", "F1MBS0-1", "F1MPL2-1", "Q95323-1", "P00921-1", "P18915-1", "Q1LZA1-1", "Q3SZX4-1", "F1N0H3-1", "E1BPA4-1", "A0A0A0MP99-1", "A0A3Q1LYT6-1" ], "evidence": [ { "id": "10748", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10748" } ] }, { "id": "R-BTA-1237045", "name": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MBS0-1" ], "evidence": [ { "id": "R-BTA-1237045", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1237045" } ] }, { "id": "R-BTA-1237081", "name": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MBS0-1" ], "evidence": [ { "id": "R-BTA-1237081", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1237081" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0A0MP99", "gene_name": "LOC100847874", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] }, { "ec_number": "4.2.1.69", "activity": "urea = cyanamide + H2O.", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] }, { "ec_number": "4.2.1.69", "activity": "", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] } ] }, { "uniprot_ac": "A0A3Q1LYT6", "gene_name": "LOC784254", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "A0A3Q1LYT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6" } ] } ] }, { "uniprot_ac": "E1BAD9", "gene_name": "CA5A", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "E1BAD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "E1BAD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" } ] } ] }, { "uniprot_ac": "E1BHA4", "gene_name": "CA7", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "E1BHA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHA4" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "E1BHA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHA4" } ] } ] }, { "uniprot_ac": "E1BPA4", "gene_name": "CA9", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "E1BPA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA4" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "E1BPA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA4" } ] } ] }, { "uniprot_ac": "F1MBS0", "gene_name": "CA6", "activity": [ { "ec_number": "4.2.1.1", "activity": 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"https://www.uniprot.org/uniprotkb/F1MG16" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MG16-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 342, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MG16-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MG16" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MG16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG16" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 4, "end_pos": 121, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 174, "end_pos": 176 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": 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}, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MI92-1", "uniprot_ac": "F1MI92", "uniprot_id": "F1MI92_BOVIN", "mass": { "chemical_mass": 71059.0, "monoisotopic_mass": 71059.0 }, "refseq": { "ac": "XP_005227129", "name": "protein phosphatase Slingshot homolog 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227129" }, "gene_names": [ { "name": "SSH3", "type": "recommended", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] }, { "name": "SSH3", "type": "synonym", "evidence": [ { "id": "XP_005227129", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227129" } ] } ], "protein_names": [ { "name": "protein-serine/threonine phosphatase", "type": "recommended", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.16", "type": "synonym", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92/entry#names_and_taxonomy" } ] }, { "name": "protein phosphatase Slingshot homolog 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005227129", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227129" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MI92", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SSH3", "url": "https://www.uniprot.org/uniprotkb/F1MI92", "locus": { "chromosome": "29", "start_pos": 45232151, "end_pos": 45224295, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000031590", "url": "https://www.ensembl.org/id/ENSBTAG00000031590" } ] } } ], "crossref": [ { "id": "F1MI92", "url": "https://alphafold.ebi.ac.uk/entry/F1MI92", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031590", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031590", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14571", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14571", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514643", "url": "https://www.ncbi.nlm.nih.gov/gene/514643", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043587", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043587", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043588", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043588", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MI92", "url": "https://www.orthodb.org/?gene=F1MI92", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45864", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45864", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45864:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45864:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00782", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00782", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08766", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08766", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23040", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23040", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005227129", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227129", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "47004", "url": "https://www.rhea-db.org/rhea/47004", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TQ78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI92", "url": "https://www.uniprot.org/uniprotkb/F1MI92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI92-1", "url": "https://www.uniprot.org/uniprotkb/F1MI92-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALVTVSRSPPASGHSTPVGPTDPVSQRRSRLQRRQSFAVLRGAVLGLQDGGDDGDASRPSPEPAEEPPGEGQPHGDQTDNGHGPPSPGRQEQSQHLCLMVELLRPQDDIRLAAQLEAARAPRLRYLLVVSTREGLSRDETVLLGVDFPDSSSPSCTLGLVLPLWSDTQVYLDGDGGFSVTSGGQSRIFKPVSIQTMWATLQVLHQACEAALSSGLVPGGSALAWASHYQDRLSSDQSCLNEWMAMADLESLRPPCVESSRPSEQEQMEQAIRAELWEVLDTSDLDNVTSKEIRQALELRLGCPLQQYRDFIDNQMLLLMAQQDRASRIFPHLYLGSEWNAANLEELQRNRVSHILNMAREIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFVEAARAQGTRVLVHCKMGVSRSAATVIAYAMKQYGWSLEQALRHVQELRPIARPNPGFLRQLQTYQGILTASRQSHVWEQKAGGASPEEPLAPEVSTPFPPLQPEPGGSGELSVMGSEDSQAAPKEAPGSRPRINLRGVMRSISLLEPPSELDSPSGDADLPEVFSSKESSDEDPPQPFPQPSSAKGGRQVHRGPWPALKSRQSVAALNSAALVASRTRAFQEQGEAGCASTPRHQKIVRQASVDSSGEEGEV", "length": 648, "header": "tr|F1MI92-1|F1MI92_BOVIN Isoform 1 of protein-serine/threonine phosphatase OS=Bos taurus OX=9913 GN=SSH3 PE=3 SV=2 CANONICAL=F1MI92-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TQ78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ78/entry", "sequence": { "sequence": "MALVTVSRSPPASGHSTPVGPTVSLAWLWSCPRSWLPVGPGGVLAAHGQPPLKPGGVRRGPSRLRLELLGGDLEATRNSDQGKIRSPEHPRRPYPALGPDLGQTLRHLQQRSPSLTSGCRPGPGPGPASVSTWKVDWNRKGFDTLSGSFPHCMGGGRDEGGGGSLHPQPQHPEPGEESFPTTLLCPGGCLLSRTRCPSAEAGSSEGRALQYSEGLSWDCRMEGMMEMLPGPAQSQRRSPPGKGSPTGTRQTMGTGPRVPAAQLEAARAPRLRYLLVVSTREGLSRDETVLLGVDFPDSSSPSCTLGLVLPLWSDTQVYLDGDGGFSVTSGGQSRIFKPVSIQTMWATLQVLHQACEAALSSGLVPGGSALAWASHYQDRLSSDQSCLNEWMAMADLESLRPPCVESSRPSEQEQMEQAIRAELWEVLDTSDLDNVTSKEIRQALELRLGCPLQQYRDFIDNQMLLLMAQQDRASRIFPHLYLGSEWNAANLEELQRNRVSHILNMAREIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFVEAARAQGTRVLVHCKMGVSRSAATVIAYAMKQYGWSLEQALRHVQELRPIARPNPGFLRQLQTYQGILTASRQSHVWEQKAGGASPEEPLAPEVSTPFPPLQPEPGGSGELSVMGSEDSQAAPKEAPGSRPRINLRGVMRSISLLEPPSELDSPSGDADLPEVFSSKESSDEDPPQPFPQPSSAKGGRQVHRGPWPALKSRQSVAALNSAALVASRTRAFQEQGEAGCASTPRHQKIVRQASVDSSGEEGEV", "length": 795, "header": "tr|A0AAA9TQ78-1|F1MI92_BOVIN Computationally mapped isoform of protein-serine/threonine phosphatase OS=Bos taurus OX=9913 GN=SSH3 PE=3 SV=1 CANONICAL=F1MI92-1" }, "locus": { "chromosome": "29", "start_pos": 45231468, "end_pos": 45224494, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108079.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108079.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099442.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099442.1" } ] } }, { "isoform_ac": "F1MI92-1", "url": "https://www.uniprot.org/uniprotkb/F1MI92/entry", "sequence": { "sequence": "MALVTVSRSPPASGHSTPVGPTDPVSQRRSRLQRRQSFAVLRGAVLGLQDGGDDGDASRPSPEPAEEPPGEGQPHGDQTDNGHGPPSPGRQEQSQHLCLMVELLRPQDDIRLAAQLEAARAPRLRYLLVVSTREGLSRDETVLLGVDFPDSSSPSCTLGLVLPLWSDTQVYLDGDGGFSVTSGGQSRIFKPVSIQTMWATLQVLHQACEAALSSGLVPGGSALAWASHYQDRLSSDQSCLNEWMAMADLESLRPPCVESSRPSEQEQMEQAIRAELWEVLDTSDLDNVTSKEIRQALELRLGCPLQQYRDFIDNQMLLLMAQQDRASRIFPHLYLGSEWNAANLEELQRNRVSHILNMAREIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFVEAARAQGTRVLVHCKMGVSRSAATVIAYAMKQYGWSLEQALRHVQELRPIARPNPGFLRQLQTYQGILTASRQSHVWEQKAGGASPEEPLAPEVSTPFPPLQPEPGGSGELSVMGSEDSQAAPKEAPGSRPRINLRGVMRSISLLEPPSELDSPSGDADLPEVFSSKESSDEDPPQPFPQPSSAKGGRQVHRGPWPALKSRQSVAALNSAALVASRTRAFQEQGEAGCASTPRHQKIVRQASVDSSGEEGEV", "length": 648, "header": "tr|F1MI92-1|F1MI92_BOVIN Isoform 1 of protein-serine/threonine phosphatase OS=Bos taurus OX=9913 GN=SSH3 PE=3 SV=2 CANONICAL=F1MI92-1" }, "locus": { "chromosome": "29", "start_pos": 45231468, "end_pos": 45224494, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018426.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018426.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018426.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018426.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 22, "start_aa": "Thr", "end_pos": 22, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr22", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "F1MI92", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ], "pmid": "" }, { "name": "protein serine/threonine phosphatase activity", "id": "GO:0004722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", "evidence": [ { "database": "UniProtKB", "id": "F1MI92", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ], "pmid": "" }, { "name": "phosphoprotein phosphatase activity", "id": "GO:0004721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004721", "evidence": [ { "database": "UniProtKB", "id": "F1MI92", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "F1MI92", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MI92", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of actin filament polymerization", "id": "GO:0030837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030837", "evidence": [ { "database": "UniProtKB", "id": "F1MI92", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "F1MI92", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "47004", "name": "", "equation": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6DLF7-1", "F1MI92-1", "A0A3Q1MV48-1", "E1BEW5-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "A0ABI0P1A3-1", "F1MBQ1-1", "A0AAA9RTM1-1", "G3N3B3-1", "A0AAF6YJP2-1", "P48452-1", "O62829-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "Q0P594-1", "A6H772-1", "O62830-1", "P61287-1", "A0AAA9U0H6-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q1RMV9-1", "Q2KJ36-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "E1BIZ2-1", "F1MI99-1", "F1MP34-1", "F1MEZ2-1", "F1MQM7-1", "F1MM08-1", "F1N719-1", "A0AAA9T455-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0AAA9TV14-1", "A0AAA9S745-1", "F1N580-1", "E1BMD4-1", "E1BF95-1", "E1BIE7-1", "A0A3Q1N224-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "47004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47004" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1MLC5", "gene_name": "DUSP8", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] } ] }, { "uniprot_ac": "A0A3Q1MV48", "gene_name": "CDC14A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] } ] }, { "uniprot_ac": "A0A3Q1MZU1", "gene_name": "CTDSPL2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MZU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZU1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MZU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZU1" } ] } ] }, { "uniprot_ac": "A0A3Q1N224", "gene_name": "PHLPP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N224" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1N224", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N224" } ] } ] }, { "uniprot_ac": "A0A3Q1N5B2", "gene_name": "CDC14B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N5B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5B2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N5B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5B2" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S454", "gene_name": "LOC112441581", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S454" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9S454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S454" } ] } ] }, { "uniprot_ac": "A0AAA9S745", "gene_name": "CTDSPL", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] } ] }, { "uniprot_ac": "A0AAA9SCR0", "gene_name": "LOC112441582", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCR0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCR0" } ] } ] }, { "uniprot_ac": "A0AAA9SWY4", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] } ] }, { "uniprot_ac": "A0AAA9T455", "gene_name": "CDKN3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] } ] }, { "uniprot_ac": "A0AAA9TD32", "gene_name": "CTDP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD32" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD32" } ] } ] }, { "uniprot_ac": "A0AAA9TT76", "gene_name": "PPP3CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] } ] }, { "uniprot_ac": "A0AAA9TV14", "gene_name": "CTDSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YJP2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": 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"A6H772", "gene_name": "PPP4C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] } ] }, { "uniprot_ac": "E1B9Y5", "gene_name": "PPEF2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] } ] }, { "uniprot_ac": "E1BAB2", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] } ] }, { "uniprot_ac": "E1BBD9", "gene_name": "LOC112445820", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] } ] }, { "uniprot_ac": "E1BEW5", "gene_name": "PPTC7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] } ] }, { "uniprot_ac": "E1BF95", "gene_name": "PPM1F", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] } ] }, { "uniprot_ac": "E1BIE7", "gene_name": "PGAM5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] } ] }, { "uniprot_ac": "E1BIZ2", "gene_name": "SSH1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] } ] }, { "uniprot_ac": "E1BMD4", "gene_name": "PHLPP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] } ] }, { "uniprot_ac": "F1MBQ1", "gene_name": "PPEF1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MI92", "gene_name": "SSH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1N580", "gene_name": "PPM1E", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] } ] }, { "uniprot_ac": "F1N719", "gene_name": "PPP5C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] } ] }, { "uniprot_ac": "F6RRD7", "gene_name": "RPAP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] } ] }, { "uniprot_ac": "G3N3B3", "gene_name": "PPM1N", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] } ] }, { "uniprot_ac": "O62829", "gene_name": "PPM1A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] } ] }, { "uniprot_ac": "O62830", "gene_name": "PPM1B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P48452", "gene_name": "PPP3CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] } ] }, { "uniprot_ac": "P61287", "gene_name": "PPP1CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] } ] }, { "uniprot_ac": "P67774", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] } ] }, { "uniprot_ac": "P79126", "gene_name": "PPM1G", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] } ] }, { "uniprot_ac": "Q0IID7", 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"MERAAQGAESGGGSNSSSRSSSRATSAGSSPSCSLAGRGVSGRSAAAGLGGGGSRSSPGSVAASPCGGSGRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGALSLSGAIVSLSDEAPHMLVVYAANGEMYKLRAADAKEKQFWVTQLRACAKYHMETNSKTTPSSRSRSLTLLPHGTSNSASPSSQRHLSAGAPGVVTITHHKSPAAARRAKSQYSGQLHEVREMMTQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLSLLQQSLHHAGQSSHRPGASESILGWHGPKSHSTEQLKNGTLGSLPSASASITWAILPNSTEDEQAFPPEPEPEPEPNSGPELVLSEDEKSDTEDQEETELGVMEDQRSVILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFLAHPDLLLAVAAGATPQDRVIGFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDKVKARRTAPPAPAGHEHPMADDSSKNYKLRFVAEQVSHHPPISCFYCECKEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSILTLPWVELGGKVSITCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLPVYPKKIRPLEKQGPMESRNLWREVTRCLRLGDMEAATEQKRRLEEKQRAEERKRENLRAPWRPKVTAGCTSTPCGRHTDGWRCRAFRNSPDFVGIKVVRYQGSAGLP", "length": 791, "header": "tr|F1MFD9-1|F1MFD9_BOVIN Isoform 1 of Oxysterol-binding protein OS=Bos taurus OX=9913 GN=OSBPL10 PE=3 SV=4 CANONICAL=F1MFD9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TR71-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR71/entry", "sequence": { "sequence": "MERAAQGAESGGGSNSSSRSSSRATSAGSSPSCSLAGRGVSGRSAAAGLGGGGSRSSPGSVAASPCGGSGRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGALSLSGAIVSLSDEAPHMLVVYAANGEMYKLRAADAKEKQFWVTQLRACAKYHMETNSKTTPSSRSRSLTLLPHGTSNSASPSSQRHLSAGAPGVVTITHHKSPAAARRAKSQYSGQLHEVREMMTQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLSLLQQSLHHAGQSSHRPGASESILGWHGPKSHSTEQLKNGTLGSLPSASASITWAILPNSTEDEQAFPPEPEPEPEVGPFAHDEHLSFQSMRAKCGKCVCMCG", "length": 396, "header": "tr|A0AAA9TR71-1|F1MFD9_BOVIN Computationally mapped isoform of Oxysterol-binding protein OS=Bos taurus OX=9913 GN=OSBPL10 PE=3 SV=1 CANONICAL=F1MFD9-1" }, "locus": { "chromosome": "22", "start_pos": 6498868, "end_pos": 6201976, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098852.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098852.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099803.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099803.1" } ] } }, { "isoform_ac": "F1MFD9-1", "url": "https://www.uniprot.org/uniprotkb/F1MFD9/entry", "sequence": { "sequence": "MERAAQGAESGGGSNSSSRSSSRATSAGSSPSCSLAGRGVSGRSAAAGLGGGGSRSSPGSVAASPCGGSGRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGALSLSGAIVSLSDEAPHMLVVYAANGEMYKLRAADAKEKQFWVTQLRACAKYHMETNSKTTPSSRSRSLTLLPHGTSNSASPSSQRHLSAGAPGVVTITHHKSPAAARRAKSQYSGQLHEVREMMTQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLSLLQQSLHHAGQSSHRPGASESILGWHGPKSHSTEQLKNGTLGSLPSASASITWAILPNSTEDEQAFPPEPEPEPEPNSGPELVLSEDEKSDTEDQEETELGVMEDQRSVILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFLAHPDLLLAVAAGATPQDRVIGFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDKVKARRTAPPAPAGHEHPMADDSSKNYKLRFVAEQVSHHPPISCFYCECKEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSILTLPWVELGGKVSITCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLPVYPKKIRPLEKQGPMESRNLWREVTRCLRLGDMEAATEQKRRLEEKQRAEERKRENLRAPWRPKVTAGCTSTPCGRHTDGWRCRAFRNSPDFVGIKVVRYQGSAGLP", "length": 791, "header": "tr|F1MFD9-1|F1MFD9_BOVIN Isoform 1 of Oxysterol-binding protein OS=Bos taurus OX=9913 GN=OSBPL10 PE=3 SV=4 CANONICAL=F1MFD9-1" }, "locus": { "chromosome": "22", "start_pos": 6498868, "end_pos": 6158284, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012114.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012114.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012114.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012114.7" } ] } }, { "isoform_ac": "G3X8E8-1", "url": "https://www.uniprot.org/uniprotkb/G3X8E8/entry", "sequence": { "sequence": "MERAAQGAESGGGSNSSSRSSSRATSAGSSPSCSLAGRGVSGRSAAAGLGGGGSRSSPGSVAASPCGGSGRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGALSLSGAIVSLSDEAPHMLVVYAANGEMYKLRAADAKEKQFWVTQLRACAKYHMETNSKMMTQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLSLLQQSLHHAGQSSHRPGASESILGWHGPKSHSTEQLKNGTLGSLPSASASITWAILPNSTEDEQAFPPEPEPEPEPNSGPELVLSEDEKSDTEDQEETELGVMEDQRSVILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFLAHPDLLLAVAAGATPQDRVIGFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDKVKARRTAPPAPAGHEHPMADDSSKNYKLRFVAEQVSHHPPISCFYCECKEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSILTLPWVELGGKVSITCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLPVYPKKIRPLEKQGPMESRNLWREVTRCLRLGDMEAATEQKRRLEEKQRAEERKRENLRAPWRPKYFIQEGDGWVYFNPLWKAH", "length": 703, "header": "tr|G3X8E8-1|F1MFD9_BOVIN Computationally mapped isoform of Oxysterol-binding protein OS=Bos taurus OX=9913 GN=OSBPL10 PE=3 SV=2 CANONICAL=F1MFD9-1" }, "locus": { "chromosome": "22", "start_pos": 6498868, "end_pos": 6158372, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063253.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063253.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055666.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055666.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1482801", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482801", "resource": "Reactome", "description": "Acyl chain remodelling of PS" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" }, { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" }, { "name": "phospholipid transfer to membrane", "id": "GO:0006649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006649", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" }, { "name": "phospholipid homeostasis", "id": "GO:0055091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055091", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" }, { "name": "lysosomal membrane organization", "id": "GO:0097212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097212", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" }, { "name": "cholesterol binding", "id": "GO:0015485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015485", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" }, { "name": "phosphatidylserine binding", "id": "GO:0001786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" }, { "name": "phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity", "id": "GO:0160270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160270", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" }, { "name": "endoplasmic reticulum-endosome membrane contact site", "id": "GO:0140284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140284", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" }, { "name": "endoplasmic reticulum-trans-Golgi network membrane contact site", "id": "GO:0160258", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160258", "evidence": [ { "database": "UniProtKB", "id": "F1MFD9", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 663, "end_pos": 665, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MFD9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 791, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MFD9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MFD9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFD9" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 74, "end_pos": 171, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 15, "end_pos": 17 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 352, "end_pos": 354 }, { "start_pos": 663, "end_pos": 665 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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} ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPM6-1", "uniprot_ac": "E1BPM6", "uniprot_id": "E1BPM6_BOVIN", "mass": { "chemical_mass": 77385.0, "monoisotopic_mass": 77385.0 }, "refseq": { "ac": "XP_005217157", "name": "telomere zinc finger-associated protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217157" }, "gene_names": [ { "name": "ZBTB48", "type": "recommended", "evidence": [ { "id": "E1BPM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ] }, { "name": "ZBTB48", "type": "synonym", "evidence": [ { "id": "XP_005217157", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217157" } ] } ], "protein_names": [ { "name": "Zinc finger and BTB domain-containing protein 48", "type": "recommended", "evidence": [ { "id": "E1BPM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPM6/entry#names_and_taxonomy" } ] }, { "name": "Telomere zinc finger-associated protein", "type": "synonym", "evidence": [ { "id": "E1BPM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPM6/entry#names_and_taxonomy" } ] }, { "name": "telomere zinc finger-associated protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005217157", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217157" } ] } ], "function": [ { "annotation": "Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A. Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression. In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs.", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6#function" }, { "database": "UniProtKB", "id": "ARBA00058760", "url": "https://www.uniprot.org/uniprotkb/ARBA00058760#function" }, { "database": "UniProtKB", "id": "A0A3Q1MEW4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEW4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZBTB48", "url": "https://www.uniprot.org/uniprotkb/E1BPM6", "locus": { "chromosome": "16", "start_pos": 46815302, "end_pos": 46823674, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016735", "url": "https://www.ensembl.org/id/ENSBTAG00000016735" } ] } } ], "crossref": [ { "id": "E1BPM6", "url": "https://alphafold.ebi.ac.uk/entry/E1BPM6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016735", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016735", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18232", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18232", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534608", "url": "https://www.ncbi.nlm.nih.gov/gene/534608", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050636", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050636", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BPM6", "url": "https://www.orthodb.org/?gene=E1BPM6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47772", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47772", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47772:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47772:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005217157", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217157", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEW4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEW4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPM6-1", "url": "https://www.uniprot.org/uniprotkb/E1BPM6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGSFVQHSVRVLQELNKQRERGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGSVVLPAGFAEIFGLLLDFFYTGHLALTSGNRDQVLLAARELRVPEAVELCQSFKPKASVGQPPSGQSGLGKSAPRDVNSHLKESAGVEKEEVSRTLGQIPRDPELSGSLSPQRPRLGLPAQSESPSFLRGKLKQALKLCPPGDKEPEDCKVPPRPFEAEGVQLQGGTNEWEVVVQVEDDGDGDYDSETETVPTKRKANVIRKPCAAEPARSVGSLAAEPAENRKGTAVPVECPTCHKKFLSKYYLKVHNSRKHTGEKPFECAKCGKCYFRKENLLEHEARNCMNRSEQVFTCSVCQETFRRRMELRVHMVSHTGEMPYKCSSCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKCFLSRTELQLHEAFKHRGEKLFVCEECGHRASSRNGLQMHIKAKHRNERPYVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHLCGKTFRTQASLDKHNRTHTGERPFSCEFCEQRFTEKGPLLRHVASRHQEGRPHFCQICGKTFKAVEQLRVHVRRHKGVRKFECTECGYKFTRQAHLRRHMEIHDRVENYNPRQRKLRNLVIEDEKMVVVALQPPPDLEVGSAEVIVESLAHGSLASQLPGQRLCAEESFTGAGVMEPSLIITAAIPEDCDT", "length": 689, "header": "tr|E1BPM6-1|E1BPM6_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 48 OS=Bos taurus OX=9913 GN=ZBTB48 PE=3 SV=3 CANONICAL=E1BPM6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MEW4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEW4/entry", "sequence": { "sequence": "MPGGGGNWIGSASLSIPLAAIYVVPPPGAGFGGKGLRPRGVPPRPARPDVTSGGGDGGVSALSPGTGTMDGSFVQHSVRVLQELNKQRERGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGSVVLPAGFAEIFGLLLDFFYTGHLALTSGNRDQVLLAARELRVPEAVELCQSFKPKASVGQPPSGQSGLGKSAPRDVNSHLKESAGVEKEEVSRTLGQIPRDPELSGSLSPQRPRLGLPAQSESPSFLRGKLKQALKLCPPGDKEPEDCKVPPRPFEAEGVQLQGGTNEWEVVVQVEDDGDGDYDSETETVPTKRKANVIRKPCAAEPARSVGSLAAEPAENRKGTAVPVECPTCHKKFLSKYYLKVHNRKHTGEKPFECAKCGKCYFRKENLLEHEARNCMNRSEQVFTCSVCQETFRRRMELRVHMVSHTGEMPYKCSSCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKCFLSRTELQLHEAFKHRGEKLFVCEECGHRASSRNGLQMHIKAKHRNERPYVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHLCGKTFRTQASLDKHNRTHTGERPFSCEFCEQRFTEKGPLLRHVASRHQEGRPHFCQICGKTFKAVEQLRVHVRRHKGVRKFECTECGYKFTRQAHLRRHMEIHDRVENYNPRQRKLRNLVIEDEKMVVVALQPPPDLEVGSAEVIVESLAHGSLASQLPGQRLCAEESFTGAGVMEPSLIITAAIPEDCDT", "length": 756, "header": "tr|A0A3Q1MEW4-1|E1BPM6_BOVIN Computationally mapped isoform of Zinc finger and BTB domain-containing protein 48 OS=Bos taurus OX=9913 GN=ZBTB48 PE=3 SV=1 CANONICAL=E1BPM6-1" }, "locus": { "chromosome": "16", "start_pos": 46823607, "end_pos": 46815372, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070680.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070680.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069050.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069050.2" } ] } }, { "isoform_ac": "E1BPM6-1", "url": "https://www.uniprot.org/uniprotkb/E1BPM6/entry", "sequence": { "sequence": "MDGSFVQHSVRVLQELNKQRERGQYCDATLDVGGLVFKAHWSVLACCSHFFQSLYGDGSGGSVVLPAGFAEIFGLLLDFFYTGHLALTSGNRDQVLLAARELRVPEAVELCQSFKPKASVGQPPSGQSGLGKSAPRDVNSHLKESAGVEKEEVSRTLGQIPRDPELSGSLSPQRPRLGLPAQSESPSFLRGKLKQALKLCPPGDKEPEDCKVPPRPFEAEGVQLQGGTNEWEVVVQVEDDGDGDYDSETETVPTKRKANVIRKPCAAEPARSVGSLAAEPAENRKGTAVPVECPTCHKKFLSKYYLKVHNSRKHTGEKPFECAKCGKCYFRKENLLEHEARNCMNRSEQVFTCSVCQETFRRRMELRVHMVSHTGEMPYKCSSCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKCFLSRTELQLHEAFKHRGEKLFVCEECGHRASSRNGLQMHIKAKHRNERPYVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHLCGKTFRTQASLDKHNRTHTGERPFSCEFCEQRFTEKGPLLRHVASRHQEGRPHFCQICGKTFKAVEQLRVHVRRHKGVRKFECTECGYKFTRQAHLRRHMEIHDRVENYNPRQRKLRNLVIEDEKMVVVALQPPPDLEVGSAEVIVESLAHGSLASQLPGQRLCAEESFTGAGVMEPSLIITAAIPEDCDT", "length": 689, "header": "tr|E1BPM6-1|E1BPM6_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 48 OS=Bos taurus OX=9913 GN=ZBTB48 PE=3 SV=3 CANONICAL=E1BPM6-1" }, "locus": { "chromosome": "16", "start_pos": 46822792, "end_pos": 46815372, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022249.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022249.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022249.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022249.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "telomere maintenance via telomere lengthening", "id": "GO:0010833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010833", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "pmid": "" }, { "name": "double-stranded telomeric DNA binding", "id": "GO:0003691", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003691", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BPM6", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 513, "end_pos": 515, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 89, "start_aa": "Cys", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BPM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPM6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 291, "end_pos": 319, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 345, "end_pos": 347 }, { "start_pos": 513, "end_pos": 515 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MFD5-1", "uniprot_ac": "F1MFD5", "uniprot_id": "F1MFD5_BOVIN", "mass": { "chemical_mass": 62942.0, "monoisotopic_mass": 62942.0 }, "refseq": { "ac": "XP_010804064", "name": "ran GTPase-activating protein 1 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010804064" }, "gene_names": [ { "name": "RANGAP1", "type": "recommended", "evidence": [ { "id": "F1MFD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" } ] }, { "name": "RANGAP1", "type": "synonym", "evidence": [ { "id": "XP_010804064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010804064" } ] } ], "protein_names": [ { "name": "Ran GTPase-activating protein 1", "type": "recommended", "evidence": [ { "id": "F1MFD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFD5/entry#names_and_taxonomy" } ] }, { "name": "ran GTPase-activating protein 1 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_010804064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010804064" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFD5", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RANGAP1", "url": "https://www.uniprot.org/uniprotkb/F1MFD5", "locus": { "chromosome": "5", "start_pos": 112396235, "end_pos": 112423352, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012481", "url": "https://www.ensembl.org/id/ENSBTAG00000012481" } ] } } ], "crossref": [ { "id": "F1MFD5", "url": "https://alphafold.ebi.ac.uk/entry/F1MFD5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012481", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012481", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00116", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00116", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616055", "url": "https://www.ncbi.nlm.nih.gov/gene/616055", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027038", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027038", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036720", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036720", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NGSMEAW", "url": "https://omabrowser.org/oma/group/NGSMEAW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1ML29", "url": "https://www.orthodb.org/?gene=A0A3Q1ML29", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MFD5", "url": "https://www.orthodb.org/?gene=F1MFD5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24113", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24113", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24113:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24113:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07834", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07834", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-141430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-141444", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2467813", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2500257", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4615885", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4615885", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9615933", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9615933", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9648025", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9793242", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9793242", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010804064", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010804064", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1ML29", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ML29-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML29-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NF03", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NF03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NF03-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NF03-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFD5", "url": "https://www.uniprot.org/uniprotkb/F1MFD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFD5-1", "url": "https://www.uniprot.org/uniprotkb/F1MFD5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTADDAKDVIKEIEDFDGLEALRLEGNTVGVEAARVIAKALEKKPELKRCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSSACFTLHELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFGIIGTLEEVHMPQNGINHPGVTALAQAFAINPLLRVINLNDNTFTEKGAVAMAKTLKTLRQVEVINFGDCLVRSKGAIAIADAIHGGLPKLKELNLSFGEIKREAALSVAEAVADKTELEKLDLNGNMLGEEGCEQLQEVLEGFNMAAVLASLSDDEGEDDEDEDEEEEEEEEEEEGEEEEEDEEEEEEEEPQQEEQGEESSTPSRKGQGPNSGEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSMLIAQQTDTSDPEKVVSAFLKVSSVFKDEASVRTAVQDAVDALMKKAFSSSAFNSNAFLTRLLIHMGLLKSEDKIKAVANLYGPLMALTHVVQQDYFPKALAPLLLAFMTKPNGALESCSFARHNLLQTLYKV", "length": 585, "header": "tr|F1MFD5-1|F1MFD5_BOVIN Isoform 1 of Ran GTPase-activating protein 1 OS=Bos taurus OX=9913 GN=RANGAP1 PE=3 SV=1 CANONICAL=F1MFD5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1ML29-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML29/entry", "sequence": { "sequence": "MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTADDAKDVIKEIEDFDGLEALRLEGNTVGVEAARVIAKALEKKPELKRCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSSACFTLHELKLNNCGMGIGGGKIIGTLEEVHMPQNGINHPGVTALAQAFAINPLLRVINLNDNTFTEKGAVAMAKTLKTLRQVEVINFGDCLVRSKGAIAIADAIHGGLPKLKELNLSFGEIKREAALSVAEAVADKTELEKLDLNGNMLGEEGCEQLQEVLEGFNMAAVLASLSDDEGEDDEDEDEEEEEEEEEEEGEEEEEDEEEEEEEEPQQEEQGEESSTPSRKGQGPNSGEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSMLIAQQTDTSDPEKVVSAFLKVSSVFKDEASVRTAVQDAVDALMKKAFSSSAFNSNAFLTRLLIHMGLLKSEDKIKAVANLYGPLMALTHVVQQDYFPKALAPLLLAFMTKPNGALESCSFARHNLLQTLYKV", "length": 540, "header": "tr|A0A3Q1ML29-1|F1MFD5_BOVIN Computationally mapped isoform of Ran GTPase-activating protein 1 OS=Bos taurus OX=9913 GN=RANGAP1 PE=3 SV=1 CANONICAL=F1MFD5-1" }, "locus": { "chromosome": "5", "start_pos": 112420680, "end_pos": 112397143, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075094.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075094.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071656.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071656.1" } ] } }, { "isoform_ac": "A0A3Q1NF03-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NF03/entry", "sequence": { "sequence": "MVGWHHQLNGHEFEQAAGDVCRFPEEPTNAATMASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTADDAKDVIKEIEDFDGLEALRLEGNTVGVEAARVIAKALEKKPELKRCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSSACFTLHELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFGIIGTLEEVHMPQNGINHPGVTALAQAFAINPLLRVINLNDNTFTEKGAVAMAKTLKTLRQVEVINFGDCLVRSKGAIAIADAIHGGLPKLKELNLSFGEIKREAALSVAEAVADKTELEKLDLNGNMLGEEGCEQLQEVLEGFNMAAVLASLSDDEGEDDEDEDEEEEEEEEEEEGEEEEEDEEEEEEEEPQQEEQGEESSTPSRKGQGPNSGEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSMLIAQQTDTSDPEKVVSAFLKVSSVFKDEASVRTAVQDAVDALMKKAFSSSAFNSNAFLTRLLIHMGLLKSEDKIKAVANLYGPLMALTHVVQQDYFPKALAPLLLAFMTKPNGALESCSFARHNLLQTLYKV", "length": 617, "header": "tr|A0A3Q1NF03-1|F1MFD5_BOVIN Computationally mapped isoform of Ran GTPase-activating protein 1 OS=Bos taurus OX=9913 GN=RANGAP1 PE=3 SV=1 CANONICAL=F1MFD5-1" }, "locus": { "chromosome": "5", "start_pos": 112421687, "end_pos": 112397143, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084742.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084742.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070267.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070267.2" } ] } }, { "isoform_ac": "F1MFD5-1", "url": "https://www.uniprot.org/uniprotkb/F1MFD5/entry", "sequence": { "sequence": "MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTADDAKDVIKEIEDFDGLEALRLEGNTVGVEAARVIAKALEKKPELKRCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSSACFTLHELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFGIIGTLEEVHMPQNGINHPGVTALAQAFAINPLLRVINLNDNTFTEKGAVAMAKTLKTLRQVEVINFGDCLVRSKGAIAIADAIHGGLPKLKELNLSFGEIKREAALSVAEAVADKTELEKLDLNGNMLGEEGCEQLQEVLEGFNMAAVLASLSDDEGEDDEDEDEEEEEEEEEEEGEEEEEDEEEEEEEEPQQEEQGEESSTPSRKGQGPNSGEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSMLIAQQTDTSDPEKVVSAFLKVSSVFKDEASVRTAVQDAVDALMKKAFSSSAFNSNAFLTRLLIHMGLLKSEDKIKAVANLYGPLMALTHVVQQDYFPKALAPLLLAFMTKPNGALESCSFARHNLLQTLYKV", "length": 585, "header": "tr|F1MFD5-1|F1MFD5_BOVIN Isoform 1 of Ran GTPase-activating protein 1 OS=Bos taurus OX=9913 GN=RANGAP1 PE=3 SV=1 CANONICAL=F1MFD5-1" }, "locus": { "chromosome": "5", "start_pos": 112420680, "end_pos": 112397143, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012125.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012125.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012125.4", "url": "https://www.ensembl.org/id/ENSBTAP00000012125.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-141430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141430", "resource": "Reactome", "description": "Inactivation of APC/C via direct inhibition of the APC/C complex" }, { "id": "R-BTA-141444", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-141444", "resource": "Reactome", "description": "Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" }, { "id": "R-BTA-2467813", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2467813", "resource": "Reactome", "description": "Separation of Sister Chromatids" }, { "id": "R-BTA-2500257", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2500257", "resource": "Reactome", "description": "Resolution of Sister Chromatid Cohesion" }, { "id": "R-BTA-4615885", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4615885", "resource": "Reactome", "description": "SUMOylation of DNA replication proteins" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-9615933", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9615933", "resource": "Reactome", "description": "Postmitotic nuclear pore complex (NPC) reformation" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" }, { "id": "R-BTA-9793242", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9793242", "resource": "Reactome", "description": "SUMOylation of nuclear envelope proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YG17-1", "protein_name": "Ran GTPase-activating protein 1", "gene_name": "RANGAP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASEDIAKLAESLAKTKVGGGQLSFKGQSLKLNTAEDAEEVIKQIEEFDGLEALRLEGNTVGVEAAKVIAKALEKKSELKRCHWSDMFTGRLRSEIPPALISLGDALITAGAQLVELDLSDNAFGPDGVRGFEALLKSPACYTLQELKLNNCGMGIGGGKILAAALKECHRKSSAQGKPLALKIFMAGRNRLENDGATALAEAFGIIGTLEEVHMPQNGINHPGITALAQAFAINSLLKVINLNDNTFTEKGAVAMAETLKALRQVEVINFGDCLVRSKGALAIADALKEGLHKLKELNLSFCEIKRDAALSVAEAIEDKVELEKLDLNGNSLGEEGCEQLQEILEGFNMATVLGSLSDDEGEEEDEEEEEEEEEEEEEEEEEEEEEEEEEQQQLKERGQGEQDSMTPKKIIGSQDSTPVPSPPVDVATFLAFPSPEKLLRLGPKCSVLIAQQTDTSDVEKVVTALLRISSVFKDEAQVKTAVHETADALMKKAFCSATFNSDAFITRLLIHMGLLKSEEKIKAVPSLYGILMTLNHMVQQDYFPKSLAPVLSAFVTKPNRALDSCSFARHMLLQTLHQL", "length": 580 }, "evidence": [ { "id": "F1MFD5", "url": "https://omabrowser.org/oma/group/F1MFD5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P11745-1", "protein_name": "Ran GTPase-activating protein 1", "gene_name": "RNA1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MATLHFVPQHEEEQVYSISGKALKLTTSDDIKPYLEELAALKTCTKLDLSGNTIGTEASEALAKCIAENTQVRESLVEVNFADLYTSRLVDEVVDSLKFLLPVLLKCPHLEIVNLSDNAFGLRTIELLEDYIAHAVNIKHLILSNNGMGPFAGERIGKALFHLAQNKKAASKPFLETFICGRNRLENGSAVYLALGLKSHSEGLKVVKLYQNGIRPKGVATLIHYGLQYLKNLEILDLQDNTFTKHASLILAKALPTWKDSLFELNLNDCLLKTAGSDEVFKVFTEVKFPNLHVLKFEYNEMAQETIEVSFLPAMEKGNLPELEKLEINGNRLDEDSDALDLLQSKFDDLEVDDFEEVDSEDEEGEDEEDEDEDEKLEEIETERLEKELLEVQVDDLAERLAETEIK", "length": 407 }, "evidence": [ { "id": "F1MFD5", "url": "https://omabrowser.org/oma/group/F1MFD5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P46060-1", "protein_name": "Ran GTPase-activating protein 1", "gene_name": "RANGAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDAKDVIKEIEDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEKVVSAFLKVSSVFKDEATVRMAVQDAVDALMQKAFNSSSFNSNTFLTRLLVHMGLLKSEDKVKAIANLYGPLMALNHMVQQDYFPKALAPLLLAFVTKPNSALESCSFARHSLLQTLYKV", "length": 587 }, "evidence": [ { "id": "F1MFD5", "url": "https://omabrowser.org/oma/group/F1MFD5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P46061-1", "protein_name": "Ran GTPase-activating protein 1", "gene_name": "Rangap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASEDIAKLAETLAKTQVAGGQLSFKGKGLKLNTAEDAKDVIKEIEEFDGLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRSEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFGIIGTLEEVHMPQNGINHPGVTALAQAFAINPLLRVINLNDNTFTEKGGVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAVRGGLPKLKELNLSFCEIKRDAALVVAEAVADKAELEKLDLNGNALGEEGCEQLQEVMDSFNMAKVLASLSDDEGEDEDEEEEGEEDDEEEEDEEDEEDDDEEEEEQEEEEEPPQRGSGEEPATPSRKILDPNSGEPAPVLSSPTPTDLSTFLSFPSPEKLLRLGPKVSVLIVQQTDTSDPEKVVSAFLKVASVFRDDASVKTAVLDAIDALMKKAFSCSSFNSNTFLTRLLIHMGLLKSEDKIKAIPSLHGPLMVLNHVVRQDYFPKALAPLLLAFVTKPNGALETCSFARHNLLQTLYNI", "length": 589 }, "evidence": [ { "id": "F1MFD5", "url": "https://omabrowser.org/oma/group/F1MFD5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VIW3-1", "protein_name": "Ran GTPase-activating protein", "gene_name": "RanGAP", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSTFNFASMAAQLGQEQGISFENKVLSWNTAADVQDVVDALNKQTTVHYLNLDGNTLGVEAAKAIGEGLKRHPEFRKALWKNMFTGRLISEIPEALKHLGAALIVAGAKLTVLDLSDNALGPNGMRGLEELLRSPVCYSLQELLLCNCGLGPEGGSMLSRALIDLHANANKAGFPLQLRVFIGSRNRLEDAGATEMATAFQTLKTFEEIVLEQNSIYIEGVEALAESFKHNPHLRVLNMNDNTLKSEGAEKIAEALPFLPLLREMSFGDCLIKTNGAYHFGEALERGNERLEVIDLGFNEINSDGGLVLVNAMGNKPKLRILNLDGNSFGEEGSEKIISEMSKLPTAAALQPFQHQEEEDLEDEYQADKQDADYEEEEEVHEHANDTTEEADEDSEGDEDDEEDEGDEEYSNVAEETAYVTTNAYTTKLFNDTTNSMASETFAVANKTISQKCTPEKFCLSQKPCSQEDFDSLDMDNKLEALQSIVNQFTGDNHLLLLVFTTLKCAHLSQSSKAALDLAVSLYQATFDYAIKTKQETRVLNYVLMQLRLLPCKEVFHSDYDVKNCRFALREALKQPTFANDNIKNSFKTFLEGAES", "length": 596 }, "evidence": [ { "id": "F1MFD5", "url": "https://omabrowser.org/oma/group/F1MFD5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "F1MFD5", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1MFD5", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "F1MFD5", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MFD5", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MFD5", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "F1MFD5", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1MFD5", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "F1MFD5", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1MFD5", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" } ], "pmid": "" }, { "name": "nuclear export", "id": "GO:0051168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051168", "evidence": [ { "database": "UniProtKB", "id": "F1MFD5", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" } ], "pmid": "" }, { "name": "protein sumoylation", "id": "GO:0016925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016925", "evidence": [ { "database": "UniProtKB", "id": "F1MFD5", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" } ], "pmid": "" }, { "name": "negative regulation of protein export from nucleus", "id": "GO:0046826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046826", "evidence": [ { "database": "UniProtKB", "id": "F1MFD5", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFD5" }, { "id": "PF07834", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07834" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ran-GTPase activating protein 1 C-terminal", "eco_id": "ECO_0000259", "start_pos": 404, "end_pos": 582, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 299, "end_pos": 301 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MHH9-1", "uniprot_ac": "F1MHH9", "uniprot_id": "F1MHH9_BOVIN", "mass": { "chemical_mass": 35169.0, "monoisotopic_mass": 35169.0 }, "refseq": { "ac": "XP_005203503", "name": "low affinity immunoglobulin gamma Fc region receptor II-b isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203503" }, "gene_names": [ { "name": "FCGR2B", "type": "recommended", "evidence": [ { "id": "F1MHH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHH9" } ] }, { "name": "CD32", "type": "synonym", "evidence": [ { "id": "XP_005203503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203503" } ] }, { "name": "FCGR2B", "type": "synonym", "evidence": [ { "id": "XP_005203503", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203503" } ] }, { "name": 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"https://www.uniprot.org/uniprotkb/F1MHH9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FCGR2B", "url": "https://www.uniprot.org/uniprotkb/F1MHH9", "locus": { "chromosome": "3", "start_pos": 7931209, "end_pos": 7947843, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021842", "url": "https://www.ensembl.org/id/ENSBTAG00000021842" } ] } } ], "crossref": [ { "id": "F1MHH9", "url": "https://alphafold.ebi.ac.uk/entry/F1MHH9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021842", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021842", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05753", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05753", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282229", "url": "https://www.ncbi.nlm.nih.gov/gene/282229", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050488", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050488", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A452DJ12", "url": "https://www.orthodb.org/?gene=A0A452DJ12", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MHH9", "url": "https://www.orthodb.org/?gene=F1MHH9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N1P1", "url": "https://www.orthodb.org/?gene=G3N1P1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11481", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11481", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11481:SF97", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11481:SF97", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13895", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13895", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2029481", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029481", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2029482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2029485", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029485", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005203503", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203503", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MZW0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZW0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MZW0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZW0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ12", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A452DJ12-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9L0", "url": "https://www.uniprot.org/uniprotkb/E1B9L0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1B9L0-1", "url": "https://www.uniprot.org/uniprotkb/E1B9L0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHH9", "url": "https://www.uniprot.org/uniprotkb/F1MHH9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHH9-1", "url": "https://www.uniprot.org/uniprotkb/F1MHH9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1P1", "url": "https://www.uniprot.org/uniprotkb/G3N1P1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1P1-1", "url": "https://www.uniprot.org/uniprotkb/G3N1P1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGIPSFLAFPAARRNRAHCTPWHPWGHMLLWTALLFLAPVSGKPADLPKAVVTIQPAWINVLREDHVTLTCQGTSFSAGNLTTWFHNGSSIHTQKQPSYSFRAGSNDSGSYRCQREQTSLSDPVHLDVISDWLLLQTPSLVFQEGEPIMLRCHSWRNQPLNKITFYQDRKSKIFSYQRTNFSIPRANLSHSGQYHCTAFIGKMLHSSQPVNITVQESSSSGPSSMTAVAIGTCFAAVAIVAAIITWFRLRRKPISALPGSPERREMGETLPEEPAGLTDAENDAARTEAENTVTYSLLSHPDVAEEDSESDYQKRL", "length": 316, "header": "tr|F1MHH9-1|F1MHH9_BOVIN Isoform 1 of Fc gamma receptor IIb OS=Bos taurus OX=9913 GN=FCGR2B PE=4 SV=3 CANONICAL=F1MHH9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MZW0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZW0/entry", "sequence": { "sequence": "MKEGGRGGANDKATLLFTSSFGLLNLPSGWNLSSLKRSQCLSCWAVRATCSLQEVMGIPSFLAFPAARRNRAHCTPWHPWGHMLLWTALLFLAPVSGKPADLPKAVVTIQPAWINVLREDHVTLTCQGTSFSAGNLTTWFHNGSSIHTQKQPSYSFRAGSNDSGSYRCQREQTSLSDPVHLDVISDWLLLQTPSLVFQEGEPIMLRCHSWRNQPLNKITFYQDRKSKIFSYQRTNFSIPRANLSHSGQYHCTAFIGKMLHSSQPVNITVQESSSSGPSSMTAVAIGTCFAAVAIVAAIITWFRLRRKPISEVGAWHTGIPCVLEMNEDTRCIVSDSFPTS", "length": 340, "header": "tr|A0A3Q1MZW0-1|F1MHH9_BOVIN Computationally mapped isoform of Fc gamma receptor IIb OS=Bos taurus OX=9913 GN=FCGR2B PE=4 SV=2 CANONICAL=F1MHH9-1" }, "locus": { "chromosome": "3", "start_pos": 7947789, "end_pos": 7932588, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073777.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073777.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061834.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061834.2" } ] } }, { "isoform_ac": "A0A452DJ12-1", "url": "https://www.uniprot.org/uniprotkb/A0A452DJ12/entry", "sequence": { "sequence": "MKEGGRGGANDKATLLFTSSFGLLNLPSGWNLSSLKRSQCLSCWAVRATCSLQEVMGIPSFLAFPAARRNRAHCTPWHPWGHMLLWTALLFLAPVSGKPADLPKAVVTIQPAWINVLREDHVTLTCQGTSFSAGNLTTWFHNGSSIHTQKQPSYSFRAGSNDSGSYRCQREQTSLSDPVHLDVISDWLLLQTPSLVFQEGEPIMLRCHSWRNQPLNKITFYQDRKSKIFSYQRTNFSIPRANLSHSGQYHCTAFIGKMLHSSQPVNITVQESSSSGPSSMTAVAIGTCFAAVAIVAAIITWFRLRRKPISAGLTDAENDAARTEAENTVTYSLLSHPDVAEEDSESDYQKRL", "length": 352, "header": "tr|A0A452DJ12-1|F1MHH9_BOVIN Computationally mapped isoform of Fc gamma receptor IIb OS=Bos taurus OX=9913 GN=FCGR2B PE=4 SV=2 CANONICAL=F1MHH9-1" }, "locus": { "chromosome": "3", "start_pos": 7947789, "end_pos": 7931701, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029114.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029114.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029114.6", "url": "https://www.ensembl.org/id/ENSBTAP00000029114.6" } ] } }, { "isoform_ac": "E1B9L0-1", "url": "https://www.uniprot.org/uniprotkb/E1B9L0/entry", "sequence": { "sequence": "MGIPSFLAFPAARRNRAHCTPWHPWGHMLLWTALLFLAPVSGKPADLPKAVVTIQPAWINVLREDHVTLTCQGTSFSAGNLTTWFHNGSSIHTQKQPSYSFRAGSNDSGSYRCQREQTSLSDPVHLDVISDWLLLQTPSLVFQEGEPIMLRCHSWRNQPLNKITFYQDRKSKIFSYQRTNFSIPRANLSHSGQYHCTAFIGKMLHSSQPVNITVQESSSSGPSSMTAVAIGTCFAAVAIVAAIITWFRLRRKPISALPGSPERREMGETLPEEPGRHWG", "length": 279, "header": "tr|E1B9L0-1|F1MHH9_BOVIN Computationally mapped isoform of Fc gamma receptor IIb OS=Bos taurus OX=9913 GN=FCGR2B PE=4 SV=3 CANONICAL=F1MHH9-1" }, "locus": { "chromosome": "3", "start_pos": 7947624, "end_pos": 7932763, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048452.4", "url": "https://www.ensembl.org/id/ENSBTAT00000048452.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045488.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045488.4" } ] } }, { "isoform_ac": "F1MHH9-1", "url": "https://www.uniprot.org/uniprotkb/F1MHH9/entry", "sequence": { "sequence": "MGIPSFLAFPAARRNRAHCTPWHPWGHMLLWTALLFLAPVSGKPADLPKAVVTIQPAWINVLREDHVTLTCQGTSFSAGNLTTWFHNGSSIHTQKQPSYSFRAGSNDSGSYRCQREQTSLSDPVHLDVISDWLLLQTPSLVFQEGEPIMLRCHSWRNQPLNKITFYQDRKSKIFSYQRTNFSIPRANLSHSGQYHCTAFIGKMLHSSQPVNITVQESSSSGPSSMTAVAIGTCFAAVAIVAAIITWFRLRRKPISALPGSPERREMGETLPEEPAGLTDAENDAARTEAENTVTYSLLSHPDVAEEDSESDYQKRL", "length": 316, "header": "tr|F1MHH9-1|F1MHH9_BOVIN Isoform 1 of Fc gamma receptor IIb OS=Bos taurus OX=9913 GN=FCGR2B PE=4 SV=3 CANONICAL=F1MHH9-1" }, "locus": { "chromosome": "3", "start_pos": 7947624, "end_pos": 7931701, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029116.7", "url": "https://www.ensembl.org/id/ENSBTAT00000029116.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029116.6", "url": "https://www.ensembl.org/id/ENSBTAP00000029116.6" } ] } }, { "isoform_ac": "G3N1P1-1", "url": "https://www.uniprot.org/uniprotkb/G3N1P1/entry", "sequence": { "sequence": "MKEGGRGGANDKATLLFTSSFGLLNLPSGWNLSSLKRSQCLSCWAVRATCSLQEVMGIPSFLAFPAARRNRAHCTPWHPWGHMLLWTALLFLAPVSGKPADLPKAVVTIQPAWINVLREDHVTLTCQGTSFSAGNLTTWFHNGSSIHTQKQPSYSFRAGSNDSGSYRCQREQTSLSDPVHLDVISDWLLLQTPSLVFQEGEPIMLRCHSWRNQPLNKITFYQDRKSKIFSYQRTNFSIPRANLSHSGQYHCTAFIGKMLHSSQPVNITVQESSSSGPSSMTAVAIGTCFAAVAIVAAIITWFRLRRKPISGLWFLLVPLVISSFLAKALTPTMARTLIFGLENP", "length": 344, "header": "tr|G3N1P1-1|F1MHH9_BOVIN Computationally mapped isoform of Fc gamma receptor IIb OS=Bos taurus OX=9913 GN=FCGR2B PE=4 SV=2 CANONICAL=F1MHH9-1" }, "locus": { "chromosome": "3", "start_pos": 7947789, "end_pos": 7936136, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065268.3", "url": "https://www.ensembl.org/id/ENSBTAT00000065268.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055792.2", "url": "https://www.ensembl.org/id/ENSBTAP00000055792.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2029481", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029481", "resource": "Reactome", "description": "FCGR activation" }, { "id": "R-BTA-2029482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029482", "resource": "Reactome", "description": "Regulation of actin dynamics for phagocytic cup formation" }, { "id": "R-BTA-2029485", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029485", "resource": "Reactome", "description": "Role of phospholipids in phagocytosis" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MHH9", "url": "https://www.uniprot.org/uniprotkb/F1MHH9" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "F1MHH9", "url": "https://www.uniprot.org/uniprotkb/F1MHH9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of immune system process", "id": "GO:0002682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002682", "evidence": [ { "database": "UniProtKB", "id": "F1MHH9", "url": "https://www.uniprot.org/uniprotkb/F1MHH9" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "F1MHH9", "url": "https://www.uniprot.org/uniprotkb/F1MHH9" } ], "pmid": "" }, { "name": "positive regulation of phagocytosis", "id": "GO:0050766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050766", "evidence": [ { "database": "UniProtKB", "id": "F1MHH9", "url": "https://www.uniprot.org/uniprotkb/F1MHH9" } ], "pmid": "" }, { "name": "positive regulation of tumor necrosis factor production", "id": "GO:0032760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032760", "evidence": [ { "database": "UniProtKB", "id": "F1MHH9", "url": "https://www.uniprot.org/uniprotkb/F1MHH9" } ], "pmid": "" }, { "name": "antibody-dependent cellular cytotoxicity", "id": "GO:0001788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001788", "evidence": [ { "database": "UniProtKB", "id": "F1MHH9", "url": "https://www.uniprot.org/uniprotkb/F1MHH9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "IgG binding", "id": "GO:0019864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019864", "evidence": [ { "database": "UniProtKB", "id": "F1MHH9", "url": "https://www.uniprot.org/uniprotkb/F1MHH9" } ], "pmid": "" }, { "name": "IgG receptor activity", "id": "GO:0019770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019770", "evidence": [ { "database": "UniProtKB", "id": "F1MHH9", "url": "https://www.uniprot.org/uniprotkb/F1MHH9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 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"sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGX5-1", "uniprot_ac": "F1MGX5", "uniprot_id": "F1MGX5_BOVIN", "mass": { "chemical_mass": 33129.0, "monoisotopic_mass": 33129.0 }, "refseq": {}, "gene_names": [ { "name": "HEXIM2", "type": "recommended", "evidence": [ { "id": "F1MGX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX5" } ] } ], "protein_names": [ { "name": "HEXIM P-TEFb complex subunit 2", "type": "synonym", "evidence": [ { "id": "F1MGX5", "database": "UniProtKB", "url": 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"Bgee", "categories": [ "Gene Expression" ] }, { "id": "614679", "url": "https://www.ncbi.nlm.nih.gov/gene/614679", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614679", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614679", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MWNREGS", "url": "https://omabrowser.org/oma/group/MWNREGS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGX5", "url": "https://www.orthodb.org/?gene=F1MGX5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13469", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13469", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13469:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13469:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15313", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15313", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1NKX7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKX7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGX5", "url": "https://www.uniprot.org/uniprotkb/F1MGX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGX5-1", "url": "https://www.uniprot.org/uniprotkb/F1MGX5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQKLSVGPRHWWRHSLSLILSLQISGTCGSPRTSPEPHDPGGSQPLTPRMESHSEEEDRPGAGGGLGWNGRSPRTQSLGACSAEAMLARKKHRRRPSKRKRHWRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPEEPNLDVPQGASHPGSSGESEAGDSDGQGRARGEFQQKDFSEAYERYHTESLQGRSKEELVRDYLDLERRLSQAEEEMRRLRQLRGCTNWRPCYQVEELAAEVERLRTENQRLRQENEMWNREGGRRGGQPGS", "length": 288, "header": "tr|F1MGX5-1|F1MGX5_BOVIN Isoform 1 of HEXIM P-TEFb complex subunit 2 OS=Bos taurus OX=9913 GN=HEXIM2 PE=3 SV=2 CANONICAL=F1MGX5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NKX7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKX7/entry", "sequence": { "sequence": "MKDWEQKKVASPNQPPPAALEEAKISGTCGSPRTSPEPHDPGGSQPLTPRMESHSEEEDRPGAGGGLGWNGRSPRTQSLGACSAEAMLARKKHRRRPSKRKRHWRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPEEPNLDVPQGASHPGSSGESEAGDSDGQGRARGEFQQKDFSEAYERYHTESLQGRSKEELVRDYLDLERRLSQAEEEMRRLRQLRGCTNWRPCYQVEELAAEVERLRTENQRLRQENEMWNREGGRRGGQPGS", "length": 288, "header": "tr|A0A3Q1NKX7-1|F1MGX5_BOVIN Computationally mapped isoform of HEXIM P-TEFb complex subunit 2 OS=Bos taurus OX=9913 GN=HEXIM2 PE=3 SV=1 CANONICAL=F1MGX5-1" }, "locus": { "chromosome": "19", "start_pos": 44828313, "end_pos": 44824149, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079474.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079474.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073035.1", "url": "https://www.ensembl.org/id/ENSBTAP00000073035.1" } ] } }, { "isoform_ac": "F1MGX5-1", "url": "https://www.uniprot.org/uniprotkb/F1MGX5/entry", "sequence": { "sequence": "MEQKLSVGPRHWWRHSLSLILSLQISGTCGSPRTSPEPHDPGGSQPLTPRMESHSEEEDRPGAGGGLGWNGRSPRTQSLGACSAEAMLARKKHRRRPSKRKRHWRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPEEPNLDVPQGASHPGSSGESEAGDSDGQGRARGEFQQKDFSEAYERYHTESLQGRSKEELVRDYLDLERRLSQAEEEMRRLRQLRGCTNWRPCYQVEELAAEVERLRTENQRLRQENEMWNREGGRRGGQPGS", "length": 288, "header": "tr|F1MGX5-1|F1MGX5_BOVIN Isoform 1 of HEXIM P-TEFb complex subunit 2 OS=Bos taurus OX=9913 GN=HEXIM2 PE=3 SV=2 CANONICAL=F1MGX5-1" }, "locus": { "chromosome": "19", "start_pos": 44828313, "end_pos": 44825197, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034824.6", "url": "https://www.ensembl.org/id/ENSBTAT00000034824.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034708.5", "url": "https://www.ensembl.org/id/ENSBTAP00000034708.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614679", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614679", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ADJ6-1", "protein_name": "HEXIM P-TEFb complex subunit 2", "gene_name": "HEXIM2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKDLEQKKVATPNQPNGNTESPAALEEAKISGAPGSPKTSPEPHDPGGSLPLTPQMESHSEEEDPPVAGGGLGWNGRGSGSQSPGGCSVEAVLARKKHRRRPSRRKRHWRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPEEPNLDVPQGASHPGSSGESEAGDSDGQGRAHGEFQQRDFSEAYERYHTESLQGRSKQELVRDYLDLERRLSQAEEETRRLQQLQGCTSRQPWRQVEELAAEVERLRTENQRLRQENEMWNREGSRRGGEPGT", "length": 293 }, "evidence": [ { "id": "F1MGX5", "url": "https://omabrowser.org/oma/group/F1MGX5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HLM9-1", "protein_name": "Protein HEXIM2", "gene_name": "Hexim2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATLNHTNCNTEASAAPEEAKTSRCPPSPQTAHEPRDFGGSLLLPLEKEIHSEDEGIASAGVGSGCNNRGPRTQSPRCCSVEAVLARKKHRRRPSKRKRHWRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPLAPYNTTQFLMDDRDLEEPNLDVLHGLSHPGSSGENEAGDSDGQGRAHGEFQQRDFSEAYERYHTESLQGRSKQELVRDYLDLERRLSQAEQESRRLQQLQGRPSRQPCQQVEELAAEVERLRTENQRLRQENEMWNRDGSCCDQEKPATEGIPRPKDETPFCAHAGQLGHKEADDR", "length": 313 }, "evidence": [ { "id": "F1MGX5", "url": "https://omabrowser.org/oma/group/F1MGX5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q3TVI4-1", "protein_name": "Protein HEXIM2", "gene_name": "Hexim2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATVNHTNCNTASPAALEEAKTSGGLRSPQIAHEPHDFGGSQLLPSGQEIQSEDEGTVPAGDGSSCNIRGSRTQSPGGCSVEAVLARKKHRRRPSKRKRHWRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPLAPYNTTQFLMNDRDLEEPNLDVLHGPSHSGSGGENEAGDSDGQGRAHGEFQQRDFSEAYERYHTESLQGRSKQELVRDYLDLERRLSQAEQETRRLRQLQGCSSRQPCQQVEELAAEVERLRTENQRLRQENEMWNREGGYCDQEKPASEGTPWPKVEAPFQTHTGQLGHREAGDR", "length": 313 }, "evidence": [ { "id": "F1MGX5", "url": "https://omabrowser.org/oma/group/F1MGX5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96MH2-1", "protein_name": "Protein HEXIM2", "gene_name": "HEXIM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMATPNQTACNAESPVALEEAKTSGAPGSPQTPPERHDSGGSLPLTPRMESHSEDEDLAGAVGGLGWNSRSPRTQSPGGCSAEAVLARKKHRRRPSKRKRHWRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPEEPNLDVPHGISHPGSSGESEAGDSDGRGRAHGEFQRKDFSETYERFHTESLQGRSKQELVRDYLELEKRLSQAEEETRRLQQLQACTGQQSCRQVEELAAEVQRLRTENQRLRQENQMWNREGCRCDEEPGT", "length": 286 }, "evidence": [ { "id": "F1MGX5", "url": "https://omabrowser.org/oma/group/F1MGX5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "F1MGX5", "url": "https://www.uniprot.org/uniprotkb/F1MGX5" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MGX5", "url": "https://www.uniprot.org/uniprotkb/F1MGX5" } ], "pmid": "" }, { "name": "negative regulation of G2/M transition of mitotic cell cycle", "id": "GO:0010972", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010972", "evidence": [ { "database": "UniProtKB", "id": "F1MGX5", "url": "https://www.uniprot.org/uniprotkb/F1MGX5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MGX5", "url": "https://www.uniprot.org/uniprotkb/F1MGX5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MGX5", "url": "https://www.uniprot.org/uniprotkb/F1MGX5" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1MGX5", "url": "https://www.uniprot.org/uniprotkb/F1MGX5" } ], "pmid": "" }, { "name": "7SK snRNA binding", "id": "GO:0097322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097322", "evidence": [ { "database": "UniProtKB", "id": "F1MGX5", "url": "https://www.uniprot.org/uniprotkb/F1MGX5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], 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"id": "515128", "url": "https://www.ncbi.nlm.nih.gov/gene/515128", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MB39", "url": "https://www.orthodb.org/?gene=F1MB39", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23121", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23121", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23121:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23121:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024832422", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832422", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RTX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB39", "url": "https://www.uniprot.org/uniprotkb/F1MB39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB39-1", "url": "https://www.uniprot.org/uniprotkb/F1MB39-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"MGCDVRVSGLLRRNLQPTLTYWSVFFSFGLCIAFLGPTLLDLRCQTRSSLPEISWVFFSQQFCLLLGSALGGVFKRTLAQSLWALFTSSLAISLVFATIPFCRDVEVLASVMALAGLAMGCIDTVANMQLVRIYQKDSAVFLQVLHFFVGFGALLSPLIADPFLSEANCLPANSTANATSVFHASRVLGRQHPEAQPRSNRTLPGLPSQDGAGTRVSYAFWIMALINVGVVATYLVLLVFSHNVVFLFVGTASLGLSLSSTFPSMLAYTEDVLQYRGCATTVLVTGAGIGEMVLQMLVGSIFQAQGSYSFLVCGVIFGGLAFTFYILLLFFHRMHPGLSSGPTRDKALGMESLESYQR", "length": 358, "header": "tr|A0AAA9RTX6-1|F1MB39_BOVIN Computationally mapped isoform of Solute carrier family 60 member 1 OS=Bos taurus OX=9913 GN=MFSD4A PE=3 SV=1 CANONICAL=F1MB39-1" }, "locus": { "chromosome": "16", "start_pos": 3360267, "end_pos": 3334988, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102446.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102446.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075471.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075471.1" } ] } }, { "isoform_ac": "F1MB39-1", "url": "https://www.uniprot.org/uniprotkb/F1MB39/entry", 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"https://www.ensembl.org/id/ENSBTAP00000006513.8" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MB39", "url": "https://www.uniprot.org/uniprotkb/F1MB39" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "F1MB39", "url": "https://www.uniprot.org/uniprotkb/F1MB39" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 177, "end_pos": 179, "annotation": 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MIV1-1", "uniprot_ac": "F1MIV1", "uniprot_id": "F1MIV1_BOVIN", "mass": { "chemical_mass": 55968.0, "monoisotopic_mass": 55968.0 }, "refseq": { "ac": "XP_005213224", "name": "zinc finger and BTB domain-containing protein 34 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213224" }, "gene_names": [ { "name": "ZBTB34", "type": "recommended", "evidence": [ { "id": "F1MIV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIV1" } ] }, { "name": "ZBTB34", "type": "synonym", "evidence": [ { "id": "XP_005213224", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213224" } ] } ], "protein_names": [ { "name": "Zinc finger and BTB domain containing 34", "type": "synonym", "evidence": [ { "id": "F1MIV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIV1/entry#names_and_taxonomy" } ] }, { "name": "zinc finger and BTB domain-containing protein 34 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005213224", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213224" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MIV1", "url": "https://www.uniprot.org/uniprotkb/F1MIV1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZBTB34", "url": "https://www.uniprot.org/uniprotkb/F1MIV1", "locus": { "chromosome": "11", "start_pos": 97661262, "end_pos": 97614647, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039343", "url": "https://www.ensembl.org/id/ENSBTAG00000039343" } ] } } ], "crossref": [ { "id": "ENSBTAG00000039343", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039343", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18220", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18220", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518084", "url": "https://www.ncbi.nlm.nih.gov/gene/518084", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518084", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518084", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MVSNTGY", "url": "https://omabrowser.org/oma/group/MVSNTGY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MIV1", "url": "https://www.orthodb.org/?gene=F1MIV1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13894", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13894", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005213224", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213224", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S2Q4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQY5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQY5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIV1", "url": "https://www.uniprot.org/uniprotkb/F1MIV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIV1-1", "url": "https://www.uniprot.org/uniprotkb/F1MIV1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSVEMDSSSFIQFDVPEYSSTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILESIHSKISVGDVDSVTVGAEETPESRNGVKDSSFFANPVEISPPYCSQVRQPTTSSDLRMETTPSKALRSSRLQEEGHSDRGSSGSVSEYEIQIEGDHEQGDLLGRESQITEVKVKMEKSDRPSCSDSSSLGDDGYHTEMVDGEQVVAVNVGSYGSVLQHAYSYCQAASQPAGGVSEAFGSLSNSSPSRSMLSCFRGGRARQKRALSVHLHSDLQGLVQGSDSEAVVSNPGFESSPRERSARGHWYPYNERLICIYCGKSFNQKGSLDRHMRLHMGITPFVCKFCGKKYTRKDQLEYHIRGHTDDKPFRCEICGKCFPFQGTLNQHLRKNHPGVAEVRSRMESPERTDVYAEQKLENDASASEMALDSRMEIHTVSDAPD", "length": 506, "header": "tr|F1MIV1-1|F1MIV1_BOVIN Isoform 1 of Zinc finger and BTB domain containing 34 OS=Bos taurus OX=9913 GN=ZBTB34 PE=4 SV=4 CANONICAL=F1MIV1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2Q4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2Q4/entry", "sequence": { "sequence": "MPPLFSRLRFMSVEMDSSSFIQFDVPEYSSTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILESIHSKISVGDVDSVTVGAEETPESRNGVKDSSFFANPVEISPPYCSQVRQPTTSSDLRMETTPSKALRSSRLQEEGHSDRGSSGSVSEYEIQIEGDHEQGDLLGRESQITEVKVKMEKSDRPSCSDSSSLGDDGYHTEMVDGEQVVAVNVGSYGSVLQHAYSYCQAASQPAGGVSEAFGSLSNSSPSRSMLSCFRGGRARQKRALSVHLHSDLQGLVQGSDSEAVVSNPGFESSPRERSARGHWYPYNERLICIYCGKSFNQKGSLDRHMRLHMGITPFVCKFCGKKYTRKDQLEYHIRGHTDDKPFRCEICGKCFPFQGTLNQHLRKNHPGVAEVRSRMESPERTDVYAEQKLENDASASEMALDSRMEIHTVSDAPD", "length": 516, "header": "tr|A0AAA9S2Q4-1|F1MIV1_BOVIN Computationally mapped isoform of Zinc finger and BTB domain containing 34 OS=Bos taurus OX=9913 GN=ZBTB34 PE=4 SV=1 CANONICAL=F1MIV1-1" }, "locus": { "chromosome": "11", "start_pos": 97654971, "end_pos": 97634246, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125977.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125977.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078006.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078006.1" } ] } }, { "isoform_ac": "A0AAA9SZ25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ25/entry", "sequence": { "sequence": "MDQFAGQRQEMRLRFMSVEMDSSSFIQFDVPEYSSTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILESIHSKISVGDVDSVTVGAEETPESRNGVKDSSFFANPVEISPPYCSQVRQPTTSSDLRMETTPSKALRSSRLQEEGHSDRGSSGSVSEYEIQIEGDHEQGDLLGRESQITEVKVKMEKSDRPSCSDSSSLGDDGYHTEMVDGEQVVAVNVGSYGSVLQHAYSYCQAASQPAGGVSEAFGSLSNSSPSRSMLSCFRGGRARQKRALSVHLHSDLQGLVQGSDSEAVVSNPGFESSPRERSARGHWYPYNERLICIYCGKSFNQKGSLDRHMRLHMGITPFVCKFCGKKYTRKDQLEYHIRGHTDDKPFRCEICGKCFPFQGTLNQHLRKNHPGVAEVRSRMESPERTDVYAEQKLENDASASEMALDSRMEIHTVSDAPD", "length": 521, "header": "tr|A0AAA9SZ25-1|F1MIV1_BOVIN Computationally mapped isoform of Zinc finger and BTB domain containing 34 OS=Bos taurus OX=9913 GN=ZBTB34 PE=4 SV=1 CANONICAL=F1MIV1-1" }, "locus": { "chromosome": "11", "start_pos": 97654971, "end_pos": 97614751, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134643.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134643.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088625.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088625.1" } ] } }, { "isoform_ac": "A0AAA9SZD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZD8/entry", "sequence": { "sequence": "MTVVVFFVHLCLYGLYLSEESLVNYETLSFLRLRFMSVEMDSSSFIQFDVPEYSSTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILESIHSKISVGDVDSVTVGAEETPESRNGVKDSSFFANPVEISPPYCSQVRQPTTSSDLRMETTPSKALRSSRLQEEGHSDRGSSGSVSEYEIQIEGDHEQGDLLGRESQITEVKVKMEKSDRPSCSDSSSLGDDGYHTEMVDGEQVVAVNVGSYGSVLQHAYSYCQAASQPAGGVSEAFGSLSNSSPSRSMLSCFRGGRARQKRALSVHLHSDLQGLVQGSDSEAVVSNPGFESSPRERSARGHWYPYNERLICIYCGKSFNQKGSLDRHMRLHMGITPFVCKFCGKKYTRKDQLEYHIRGHTDDKPFRCEICGKCFPFQGTLNQHLRKNHPGVAEVRSRMESPERTDVYAEQKLENDASASEMALDSRMEIHTVSDAPD", "length": 541, "header": "tr|A0AAA9SZD8-1|F1MIV1_BOVIN Computationally mapped isoform of Zinc finger and BTB domain containing 34 OS=Bos taurus OX=9913 GN=ZBTB34 PE=4 SV=1 CANONICAL=F1MIV1-1" }, "locus": { "chromosome": "11", "start_pos": 97668271, "end_pos": 97660406, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090194.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090194.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091821.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091821.1" } ] } }, { "isoform_ac": "A0AAA9TQY5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQY5/entry", "sequence": { "sequence": "MENLMEESDSRLRFMSVEMDSSSFIQFDVPEYSSTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILESIHSKISVGDVDSVTVGAEETPESRNGVKDSSFFANPVEISPPYCSQVRQPTTSSDLRMETTPSKALRSSRLQEEGHSDRGSSGSVSEYEIQIEGDHEQGDLLGRESQITEVKVKMEKSDRPSCSDSSSLGDDGYHTEMVDGEQVVAVNVGSYGSVLQHAYSYCQAASQPAGGVSEAFGSLSNSSPSRSMLSCFRGGRARQKRALSVHLHSDLQGLVQGSDSEAVVSNPGFESSPRERSARGHWYPYNERLICIYCGKSFNQKGSLDRHMRLHMGITPFVCKFCGKKYTRKDQLEYHIRGHTDDKPFRCEICGKCFPFQGTLNQHLRKNHPGVAEVRSRMESPERTDVYAEQKLENDASASEMALDSRMEIHTVSDAPD", "length": 520, "header": "tr|A0AAA9TQY5-1|F1MIV1_BOVIN Computationally mapped isoform of Zinc finger and BTB domain containing 34 OS=Bos taurus OX=9913 GN=ZBTB34 PE=4 SV=1 CANONICAL=F1MIV1-1" }, "locus": { "chromosome": "11", "start_pos": 97654971, "end_pos": 97636777, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131648.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131648.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100774.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100774.1" } ] } }, { "isoform_ac": "F1MIV1-1", "url": "https://www.uniprot.org/uniprotkb/F1MIV1/entry", "sequence": { "sequence": "MSVEMDSSSFIQFDVPEYSSTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILESIHSKISVGDVDSVTVGAEETPESRNGVKDSSFFANPVEISPPYCSQVRQPTTSSDLRMETTPSKALRSSRLQEEGHSDRGSSGSVSEYEIQIEGDHEQGDLLGRESQITEVKVKMEKSDRPSCSDSSSLGDDGYHTEMVDGEQVVAVNVGSYGSVLQHAYSYCQAASQPAGGVSEAFGSLSNSSPSRSMLSCFRGGRARQKRALSVHLHSDLQGLVQGSDSEAVVSNPGFESSPRERSARGHWYPYNERLICIYCGKSFNQKGSLDRHMRLHMGITPFVCKFCGKKYTRKDQLEYHIRGHTDDKPFRCEICGKCFPFQGTLNQHLRKNHPGVAEVRSRMESPERTDVYAEQKLENDASASEMALDSRMEIHTVSDAPD", "length": 506, "header": "tr|F1MIV1-1|F1MIV1_BOVIN Isoform 1 of Zinc finger and BTB domain containing 34 OS=Bos taurus OX=9913 GN=ZBTB34 PE=4 SV=4 CANONICAL=F1MIV1-1" }, "locus": { "chromosome": "11", "start_pos": 97654971, "end_pos": 97653454, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052718.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052718.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051553.4", "url": "https://www.ensembl.org/id/ENSBTAP00000051553.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518084", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518084", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1ALG4-1", "protein_name": "Zinc finger and BTB domain containing 34", "gene_name": "ZBTB34", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRFHFTSVEMDSSSFIQFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILESIHSKISVGDVDSVTVGAEENSENRNGVKDSSYFANPIEISPPYCSQVRQSTASSDLRMETTPGKTLRSRLQEEGHSDRGSSGSISEYEVQIEGDHEQGDLIVRESQIAEVKVKMEKSDRPSCSDSSSLGDDGYHTEMVDGEQVVAVNVGSYGSVLQHVYSFTHASSQATGVSETFGNLSNSSPSRSMLSCFRGGRARQKRISAGHLHTDVQGLVQGTDGDSMVSNTGYENSPRERNARGHWYPYNERLICIYCGKSFNQKGSLDRHMRLHMGITPFVCKFCGKKYTRKDQLEYHIRGHTDDKPFRCEICGKCFPFQGTLNQHLRKNHPGVTEVRNRVESPDRTEAFVEQKVDNDASASETMDSSMEIHAMSNTSD", "length": 508 }, "evidence": [ { "id": "F1MIV1", "url": "https://omabrowser.org/oma/group/F1MIV1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2ATY4-1", "protein_name": "Zinc finger and BTB domain containing 34", "gene_name": "Zbtb34", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESTLEECNSRLRFVSGEMDNSSFIQFDVPEHSSTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPSVFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILESIHSKISVGDVDSVTIGAEENPESRNGVKDGSFFTNPVEISPPYCPQVRQPPVSSDLRMETTPNKALRSRLQEEGHSDRGSSGSVSEYEIQIEGDHEQGDLLVRESQITEVKVKMEKSDRPSCSDSSSLGDDGYHTEMVDGEQVVAVNVGAYGSVLQHAYPYSQTASQPSSVPEAFGGQTNSSPSRSMLSCFRGRGARQKRALSVHLHSDLQGVVQGSDSEAMMNNPGYESSPRERSARGYWYPYNERLICIYCGKSFNQKGSLDRHMRLHMGITPFVCKFCGKKYTRKDQLEYHIRGHTDDKPFRCEVCGKCFPFQGTLNQHLRKNHPGVTEGRGRMESPERTDMYVEQKLESDASASEMALDSRLEMHTVSDAPD", "length": 518 }, "evidence": [ { "id": "F1MIV1", "url": "https://omabrowser.org/oma/group/F1MIV1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B0V1A3-1", "protein_name": "Zinc finger and BTB domain-containing protein 34", "gene_name": "zbtb34", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEDCGSLIEFDVPEFSNTVLNQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSSLGTMSGLSISVIKSPEVFEQLLAFCYTGRMALRLRDVISFLTAASFLQMQAVIDKCTQILEGIHSKISIPASGEIDPDNECTTSRAGRNGVKDRGIFVNPTEISPSHFSRQNHCMEGQSSGKGIAEEGQSDRGSSDSISEQEASMEVESEQVELIGKDGQVTDVHIKLEKTDRPSYSDSSSAGDDGYHTELVDGEQVLAVSVGSYMPVLSSVGYTYSALPSSCFVSLSSSSPSRSLLSSVRGGRARPKRPVPLPVDMLTQPKPGADEGEPPATTATFENDVRERSLRGQWYPYNERLICIYCGKSFNQKGSLDRHMRLHMGITPFVCKFCGKKYTRKDQLEYHIRGHTDNKPFHCQICGKCFPFQGTLNQHLRKKHMTSGTEINNHTDLLEEAPDGQRGEQEDISEGEAACGAAYPDDLSKKSPSEESGKCSPEEPPASKLLRGY", "length": 508 }, "evidence": [ { "id": "F1MIV1", "url": "https://omabrowser.org/oma/group/F1MIV1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1LW70-1", "protein_name": "Zinc finger and BTB domain containing 34", "gene_name": "Zbtb34", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSSSFIQFDVPEHSSTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPSVFEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILESIHSKISVGDVDSVTIGAEETPESRNGVKDGSFFTSPVEISPPYCPQVRQPPVSSDLRMETTPNKALRSRLQEEGHSDRGSSGSVSEYEVQIEGDHEQGDLLVRESQITEVKVKMEKSDRPSCSDSSSLGDDGYHTEMVDGEQVVAVNVGTYGSVLQHAYPYSQAASQPSSVPEAFGGQTNSSPSRSMLSCFRGRGARQKRALSVHLHSDLQGVVQGSDSEAMMNNPGYESSPRERSARGYWYPYNERLICIYCGKSFNQKGSLDRHMRLHMGITPFVCKFCGKKYTRKDQLEYHIRGHTDDKPFRCEVCGKCFPFQGTLNQHLRKNHPGVTEGRGRMESPERTDVYGEQKLESDASASEMALDSRLEIHTVSDAPD", "length": 500 }, "evidence": [ { "id": "F1MIV1", "url": "https://omabrowser.org/oma/group/F1MIV1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NCN2-1", "protein_name": "Zinc finger and BTB domain-containing protein 34", "gene_name": "ZBTB34", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"UniProtKB", "id": "F1MIV1", "url": "https://www.uniprot.org/uniprotkb/F1MIV1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MIV1", "url": "https://www.uniprot.org/uniprotkb/F1MIV1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MIV1", "url": "https://www.uniprot.org/uniprotkb/F1MIV1" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "F1MIV1", "url": "https://www.uniprot.org/uniprotkb/F1MIV1" } ], "pmid": "" }, { "name": "regulation of immune system process", "id": "GO:0002682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002682", "evidence": [ { "database": "UniProtKB", "id": "F1MIV1", "url": "https://www.uniprot.org/uniprotkb/F1MIV1" } ], "pmid": "" }, { "name": "regulation of cytokine production", "id": "GO:0001817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817", "evidence": [ { "database": "UniProtKB", "id": "F1MIV1", "url": "https://www.uniprot.org/uniprotkb/F1MIV1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MIV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIV1" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 36, "end_pos": 100, "start_aa": "Cys", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MIV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIV1" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 378, "end_pos": 405, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 310, "end_pos": 312 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", 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"total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGH0-1", "uniprot_ac": "F1MGH0", "uniprot_id": "F1MGH0_BOVIN", "mass": { "chemical_mass": 63919.0, "monoisotopic_mass": 63919.0 }, "refseq": { "ac": "XP_024841703", "name": "transcription factor COE3 isoform X5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841703" }, "gene_names": [ { "name": "EBF3", "type": "recommended", "evidence": [ { "id": "F1MGH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH0" } ] }, { "name": "EBF3", "type": "synonym", "evidence": [ { "id": "XP_024841703", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841703" } ] } ], "protein_names": [ { "name": "Transcription factor COE3", "type": "recommended", "evidence": [ { "id": "F1MGH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH0/entry#names_and_taxonomy" } ] }, { "name": "Early B-cell factor 3", 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[9913]" } ], "gene": [ { "name": "EBF3", "url": "https://www.uniprot.org/uniprotkb/F1MGH0", "locus": { "chromosome": "26", "start_pos": 49155258, "end_pos": 49271639, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008272", "url": "https://www.ensembl.org/id/ENSBTAG00000008272" } ] } } ], "crossref": [ { "id": "F1MGH0", "url": "https://alphafold.ebi.ac.uk/entry/F1MGH0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008272", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008272", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01175", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01175", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11606", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11606", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525353", "url": "https://www.ncbi.nlm.nih.gov/gene/525353", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003523", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003523", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038006", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038006", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR10747", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10747", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01833", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01833", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16422", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16422", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16423", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16423", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024841703", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841703", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8U4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8U4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDV5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDV5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWA3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWA3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWA3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGH0", "url": "https://www.uniprot.org/uniprotkb/F1MGH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGH0-1", "url": "https://www.uniprot.org/uniprotkb/F1MGH0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFGIQENIPRGGTTMKEEPLGSGMNPVRSWMHTAGVVDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNEKTNNGIHYKLQLLYSNGVRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQIPTLGNTPAHTGMMGVNSFSSQLAVNVSETSQANDQVGYSRNTSSVSPRGYAPSSTPQQSNYSTVSTSMNGYGSGAMANLGVPGSPGFLNGSSANSPYGIVPSSPTMAASSVTLPSNCSSTHGIFSFSPANVISAVKQKSAFAPVVRPQASPPPSCTSTNGNGLQAMSGLVVPPM", "length": 587, "header": "tr|F1MGH0-1|F1MGH0_BOVIN Isoform 1 of Transcription factor COE3 OS=Bos taurus OX=9913 GN=EBF3 PE=3 SV=4 CANONICAL=F1MGH0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8U4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U4/entry", "sequence": { "sequence": "MFGIQENIPRGGTTMKEEPLGSGMNPVRSWMHTAGVVDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNEKTNNGIHYKLQLLYSNGVRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQIPTLGNTPAHTGMMGVNSFSSQLAVNVSETSQANDQVGYSRNTSSVSPRGYAPSSTPQQSNYSTVSTSMNGYGSGAMANLGVPGSPGFLNGSSANSPYGMKQKSAFAPVVRPQASPPPSCTSTNGNGLQGSLLGAEDATVEKTNWPFCEVGGIFHFDELMLKKGTGKLCLGW", "length": 584, "header": "tr|A0AAA9S8U4-1|F1MGH0_BOVIN Computationally mapped isoform of Transcription factor COE3 OS=Bos taurus OX=9913 GN=EBF3 PE=3 SV=1 CANONICAL=F1MGH0-1" }, "locus": { "chromosome": "26", "start_pos": 49271440, "end_pos": 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taurus OX=9913 GN=EBF3 PE=3 SV=1 CANONICAL=F1MGH0-1" }, "locus": { "chromosome": "26", "start_pos": 49271440, "end_pos": 49158190, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122104.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122104.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101459.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101459.1" } ] } }, { "isoform_ac": "F1MGH0-1", "url": "https://www.uniprot.org/uniprotkb/F1MGH0/entry", "sequence": { "sequence": "MFGIQENIPRGGTTMKEEPLGSGMNPVRSWMHTAGVVDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNEKTNNGIHYKLQLLYSNGVRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQIPTLGNTPAHTGMMGVNSFSSQLAVNVSETSQANDQVGYSRNTSSVSPRGYAPSSTPQQSNYSTVSTSMNGYGSGAMANLGVPGSPGFLNGSSANSPYGIVPSSPTMAASSVTLPSNCSSTHGIFSFSPANVISAVKQKSAFAPVVRPQASPPPSCTSTNGNGLQAMSGLVVPPM", "length": 587, "header": "tr|F1MGH0-1|F1MGH0_BOVIN Isoform 1 of Transcription factor COE3 OS=Bos taurus OX=9913 GN=EBF3 PE=3 SV=4 CANONICAL=F1MGH0-1" }, "locus": { "chromosome": "26", "start_pos": 49271440, "end_pos": 49156262, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010887.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010887.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010887.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010887.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 253, "start_aa": "Thr", "end_pos": 253, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr253", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": 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"https://www.uniprot.org/uniprotkb/A0A3Q1LZV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZV0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9M0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9M0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T404", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T404", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T404-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T404-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCK0", "url": "https://www.uniprot.org/uniprotkb/F1MCK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCK0-1", "url": "https://www.uniprot.org/uniprotkb/F1MCK0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQSRPPPPPPPPPPPPLSPGITSETTSPSAPASARGIYLMGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPKSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRLATELRKTNDINCCLSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLLAVREIYGPHAVSLREYGAIDDVDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQYLNGPVPTVDVFQISTKERFGLGHQLKKIMQTFVTQQWKQSKEKSNCLHNKKLSEKKVKSPLHLFSTLRRSPSYPPPGCGKSKSKLKSEQDGISKTHKLLRRTCSSTVKTEDVCAPKPHRTFGRSLSSDPRAEQAVTTIKSHKLLNRPCSAAVKQEDCLALKSHKLLTRSCSGDPRCEHNASLKPHKLLSRSYSSNLRMEELYGLKNHKLLSKSYSSAPKSSKTELFKEPNTEGRRLSLTSGLIGILTPSSSSSSQPAPNGAKCIPIRDRGFLVQTIEFAEQRIPVLNEYCVVCDEPHVFQNGPMLRPTVCERELCVFAFQTLGVMNEAADEIATGAQVVDLLVSMCRSALESPRKVVIFEPYPSVVDPNDPQMLAFNPRKKNYDRVMKALDSITSIREMTQAPYLEIKKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQLKFMHTPHQFLLLSSPPAKESNFRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSISFGYSGMNKKQKVSAKDEPASSSKNSNASQSQKKGQQSQFLQSRNLKCIALCEVITSPDLHKHGEIWVVPNTDHVCTRFFFVYEDGQVGDANINTQEGGIHKEILRVIGNQTATG", "length": 893, "header": "tr|F1MCK0-1|F1MCK0_BOVIN Isoform 1 of Poly [ADP-ribose] polymerase OS=Bos taurus OX=9913 GN=PARP8 PE=3 SV=3 CANONICAL=F1MCK0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZV0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZV0/entry", "sequence": { "sequence": "MQSRPPPPPPPPPPPPLSPGITSETTSPSAPASARGIYLMGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPKSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRLATELRKTNDINCCLSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLLAVREIYGPHAVSLREYGAIDDVDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQYLNGPVPTVDVFQISTKERFGLGHQLKKIMQTFVTQQWKQSKEKSNCLHNKKLSEKKVKSPLHLFSTLRRSPSYPPPGCGKSKSKLKSEQDGISKTHKLLRRTCSSTVKTEDVCAPKPHRTFGRSLSSDPRAEQAVTTIKSHKLLNRPCSAAVKQEDCLALKSHKLLTRSCSGDPRCEHNASLKPHKLLSRSYSSNLRMEELYGLKNHKLLSKSYSSAPKSSKTELFKEPNTEGRRLSLTSGLIGILTPSSSSSSQPAPNGAKCIPIRDRGFLVQTIEFAEQRIPVLNEYCVVCDEPHVFQNGPMLRPTVCERELCVFAFQTLGVMNEAADEIATGAQKKNYDRVMKALDSITSIREMTQAPYLEIKKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQLKFMHTPHQFLLLSSPPAKESNFRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSISFGYSGMNKKQKVSAKDEPASSSKNSNASQSQKKGQQSQFLQSRNLKCIALCEVITSPDLHKHGEIWVVPNTDHVCTRFFFVYEDGQVGDANINTQEGGIHKEILRVIGNQTATG", "length": 851, "header": "tr|A0A3Q1LZV0-1|F1MCK0_BOVIN Computationally mapped isoform of Poly [ADP-ribose] polymerase OS=Bos taurus OX=9913 GN=PARP8 PE=3 SV=2 CANONICAL=F1MCK0-1" }, "locus": { "chromosome": "20", "start_pos": 28494567, "end_pos": 28303223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069029.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069029.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063189.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063189.2" } ] } }, { "isoform_ac": "A0AAA9S9M0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9M0/entry", "sequence": { "sequence": "MDGKTEQSRTGIYLMGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPKSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRLATELRKTNDINCCLSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLLAVREIYGPHAVSLREYGAIDDVDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQYLNGPVPTVDVFQISTKERFGLGHQLKKIMQTFVTQQWKQSKEKSNCLHNKKLSEKKVKSPLHLFSTLRRSPSYPPPGCGKSKSKLKSEQDGISKTHKLLRRTCSSTVKTEDVCAPKPHRTFGRSLSSDPRAEQAVTTIKSHKLLNRPCSAAVKQEDCLALKSHKLLTRSCSGDPRCEHNASLKPHKLLSRSYSSNLRMEELYGLKNHKLLSKSYSSAPKSSKTELFKEPNTEGRRLSLTSGLIGILTPSSSSSSQPAPNGAKCIPIRDRGFLVQTIEFAEQRIPVLNEYCVVCDEPHVFQNGPMLRPTVCERELCVFAFQTLGVMNEAADEIATGAQVVDLLVSMCRSALESPRKVVIFEPYPSVVDPNDPQMLAFNPRKKNYDRVMKALDSITSIREMTQAPYLEIKKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQLKFMHTPHQFLLLSSPPAKESNFRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSISFGYSGMNKKQKVSAKDEPASSSKNSNASQSQKKGQQSQFLQSRNLKCIALCEVITSPDLHKHGEIWVVPNTDHVCTRFFFVYEDGQVGDANINTQEGGIHKEILRVIGNQTATG", "length": 868, "header": "tr|A0AAA9S9M0-1|F1MCK0_BOVIN Computationally mapped isoform of Poly [ADP-ribose] polymerase OS=Bos taurus OX=9913 GN=PARP8 PE=3 SV=1 CANONICAL=F1MCK0-1" }, "locus": { "chromosome": "20", "start_pos": 28495429, "end_pos": 28303223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116240.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116240.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081986.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081986.1" } ] } }, { "isoform_ac": "A0AAA9T404-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T404/entry", "sequence": { "sequence": "MGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPKSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRLATELRKTNDINCCLSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLLAVREIYGPHAVSLREYGAIDDVDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQYLNGPVPTVDVFQISTKERFGLGHQLKKIMQTFVTQQWKQSKEKSNCLHNKKLSEKKVKSPLHLFSTLRRSPSYPPPGCGKSKSKLKSEQDGISKTHKLLRRTCSSTVKTEDVCAPKPHRTFGRSLSSDPRAEQAVTTIKSHKLLNRPCSAAVKQEDCLALKSHKLLTRSCSGDPRCEHNASLKPHKLLSRSYSSNLRMEELYGLKNHKLLSKSYSSAPKSSKTELFKEPNTEGRRLSLTSGLIGILTPSSSSSSQPAPNGAKCIPIRDRGFLVQTIEFAEQRIPVLNEYCVVCDEPHVFQNGPMLRPTVCERELCVFAFQTLGVMNEAADEIATGAQVVDLLVSMCRSALESPRKVVIFEPYPSVVDPNDPQMLAFNPRKKNYDRVMKALDSITSIREMTQAPYLEIKKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQLKFMHTPHQFLLLSSPPAKESNFRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSISFGYSGMNKKQKVSAKDEPASSSKNSNASQSQKKGQQSQFLQSRNLKCIALCEVITSPDLHKHGEIWVVPNTDHVCTRFFFVYEDGQVGDANINTQEGGIHKEILRVIVYLRREENDQTFKKRKTVIIYL", "length": 869, "header": "tr|A0AAA9T404-1|F1MCK0_BOVIN Computationally mapped isoform of Poly [ADP-ribose] polymerase OS=Bos taurus OX=9913 GN=PARP8 PE=3 SV=1 CANONICAL=F1MCK0-1" }, "locus": { "chromosome": "20", "start_pos": 28494363, "end_pos": 28300361, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120943.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120943.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093533.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093533.1" } ] } }, { "isoform_ac": "A0AAA9TXN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXN7/entry", "sequence": { "sequence": "MPRKKERCPRSLRRPEPLLGGRLSSILLPLEGDRILLPEPTAQRGPLPAARTGKFPPLPWHPALVAGGGHARHPARDFRYSDSTFTFTYVGGPKSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRLATELRKTNDINCCLSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLLAVREIYGPHAVSLREYGAIDDVDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQYLNGPVPTVDVFQISTKERFGLGHQLKKIMQTFVTQQWKQSKEKSNCLHNKKLSEKKVKSPLHLFSTLRRSPSYPPPGCGKSKSKLKSEQDGISKTHKLLRRTCSSTVKTEDVCAPKPHRTFGRSLSSDPRAEQAVTTIKSHKLLNRPCSAAVKQEDCLALKSHKLLTRSCSGDPRCEHNASLKPHKLLSRSYSSNLRMEELYGLKNHKLLSKSYSSAPKSSKTELFKEPNTEGRRLSLTSGLIGILTPSSSSSSQPAPNGAKCIPIRDRGFLVQTIEFAEQRIPVLNEYCVVCDEPHVFQNGPMLRPTVCERELCVFAFQTLGVMNEAADEIATGAQVVDLLVSMCRSALESPRKVVIFEPYPSVVDPNDPQMLAFNPRKKNYDRVMKALDSITSIREMTQAPYLEIKKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQLKFMHTPHQFLLLSSPPAKESNFRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSISFGYSGMNKKQKVSAKDEPASSSKNSNASQSQKKGQQSQFLQSRNLKCIALCEVITSPDLHKHGEIWVVPNTDHVCTRFFFVYEDGQVGDANINTQEGGIHKEILRVIGNQTATG", "length": 900, "header": "tr|A0AAA9TXN7-1|F1MCK0_BOVIN Computationally mapped isoform of Poly [ADP-ribose] polymerase OS=Bos taurus OX=9913 GN=PARP8 PE=3 SV=1 CANONICAL=F1MCK0-1" }, "locus": { "chromosome": "20", "start_pos": 28493712, "end_pos": 28303223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121500.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121500.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102242.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102242.1" } ] } }, { "isoform_ac": "F1MCK0-1", "url": "https://www.uniprot.org/uniprotkb/F1MCK0/entry", "sequence": { "sequence": "MQSRPPPPPPPPPPPPLSPGITSETTSPSAPASARGIYLMGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPKSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRLATELRKTNDINCCLSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLLAVREIYGPHAVSLREYGAIDDVDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQYLNGPVPTVDVFQISTKERFGLGHQLKKIMQTFVTQQWKQSKEKSNCLHNKKLSEKKVKSPLHLFSTLRRSPSYPPPGCGKSKSKLKSEQDGISKTHKLLRRTCSSTVKTEDVCAPKPHRTFGRSLSSDPRAEQAVTTIKSHKLLNRPCSAAVKQEDCLALKSHKLLTRSCSGDPRCEHNASLKPHKLLSRSYSSNLRMEELYGLKNHKLLSKSYSSAPKSSKTELFKEPNTEGRRLSLTSGLIGILTPSSSSSSQPAPNGAKCIPIRDRGFLVQTIEFAEQRIPVLNEYCVVCDEPHVFQNGPMLRPTVCERELCVFAFQTLGVMNEAADEIATGAQVVDLLVSMCRSALESPRKVVIFEPYPSVVDPNDPQMLAFNPRKKNYDRVMKALDSITSIREMTQAPYLEIKKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQLKFMHTPHQFLLLSSPPAKESNFRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSISFGYSGMNKKQKVSAKDEPASSSKNSNASQSQKKGQQSQFLQSRNLKCIALCEVITSPDLHKHGEIWVVPNTDHVCTRFFFVYEDGQVGDANINTQEGGIHKEILRVIGNQTATG", "length": 893, "header": "tr|F1MCK0-1|F1MCK0_BOVIN Isoform 1 of Poly [ADP-ribose] polymerase OS=Bos taurus OX=9913 GN=PARP8 PE=3 SV=3 CANONICAL=F1MCK0-1" }, "locus": { "chromosome": "20", "start_pos": 28494567, "end_pos": 28303223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005313.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005313.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005313.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005313.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "nucleotidyltransferase activity", "id": "GO:0016779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016779", "evidence": [ { "database": "UniProtKB", "id": "F1MCK0", "url": "https://www.uniprot.org/uniprotkb/F1MCK0" } ], "pmid": "" }, { "name": "NAD+ poly-ADP-ribosyltransferase activity", "id": "GO:0003950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003950", "evidence": [ { "database": "UniProtKB", "id": "F1MCK0", "url": "https://www.uniprot.org/uniprotkb/F1MCK0" } ], "pmid": "" }, { "name": "NAD+-protein mono-ADP-ribosyltransferase activity", "id": "GO:1990404", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990404", "evidence": [ { "database": "UniProtKB", "id": "F1MCK0", "url": "https://www.uniprot.org/uniprotkb/F1MCK0" } ], "pmid": "" }, { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "F1MCK0", "url": "https://www.uniprot.org/uniprotkb/F1MCK0" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activator activity", "id": "GO:0043539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043539", "evidence": [ { "database": "UniProtKB", "id": "F1MCK0", "url": "https://www.uniprot.org/uniprotkb/F1MCK0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein auto-ADP-ribosylation", "id": "GO:0070213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070213", "evidence": [ { "database": "UniProtKB", "id": "F1MCK0", "url": "https://www.uniprot.org/uniprotkb/F1MCK0" } ], "pmid": "" }, { "name": "endoplasmic reticulum unfolded protein response", "id": "GO:0030968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968", "evidence": [ { "database": "UniProtKB", "id": "F1MCK0", "url": "https://www.uniprot.org/uniprotkb/F1MCK0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nuclear envelope", "id": "GO:0005635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", "evidence": [ { "database": "UniProtKB", "id": "F1MCK0", "url": "https://www.uniprot.org/uniprotkb/F1MCK0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MCK0", "url": "https://www.uniprot.org/uniprotkb/F1MCK0" } ], "pmid": "" }, { "name": "endoplasmic reticulum tubular network", "id": "GO:0071782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071782", "evidence": [ { "database": "UniProtKB", "id": "F1MCK0", "url": "https://www.uniprot.org/uniprotkb/F1MCK0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 437, "end_pos": 439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 687, "end_pos": 689, "annotation": "n_glycosylation_sequon" }, { "start_pos": 805, "end_pos": 807, "annotation": "n_glycosylation_sequon" }, { "start_pos": 888, "end_pos": 890, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MCK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCK0" }, { "id": "PS51059", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51059" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PARP catalytic", "eco_id": "ECO_0000259", "start_pos": 656, "end_pos": 883, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 159, "end_pos": 161 }, { "start_pos": 170, "end_pos": 172 }, { "start_pos": 437, "end_pos": 439 }, { "start_pos": 687, "end_pos": 689 }, { "start_pos": 805, "end_pos": 807 }, { "start_pos": 888, "end_pos": 890 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", 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"tr|A0AAA9THL6-1|F1MBT2_BOVIN Computationally mapped isoform of Leucine rich repeat and Ig domain containing 1 OS=Bos taurus OX=9913 GN=LINGO1 PE=4 SV=1 CANONICAL=F1MBT2-1" }, "locus": { "chromosome": "21", "start_pos": 32766642, "end_pos": 32764264, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092319.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092319.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095704.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095704.1" } ] } }, { "isoform_ac": "F1MBT2-1", "url": "https://www.uniprot.org/uniprotkb/F1MBT2/entry", "sequence": { "sequence": 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"uniprot_ac": "F1MC73", "uniprot_id": "F1MC73_BOVIN", "mass": { "chemical_mass": 41732.0, "monoisotopic_mass": 41732.0 }, "refseq": { "ac": "XP_005218297", "name": "carbohydrate deacetylase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218297" }, "gene_names": [ { "name": "YDJC", "type": "recommended", "evidence": [ { "id": "F1MC73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC73" } ] }, { "name": "YDJC", "type": "synonym", "evidence": [ { "id": "XP_005218297", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218297" } ] } ], "protein_names": [ { "name": "Carbohydrate deacetylase", "type": "recommended", "evidence": [ { "id": "F1MC73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC73/entry#names_and_taxonomy" } ] }, { "name": "carbohydrate deacetylase isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005218297", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218297" } ] } ], "function": [ { "annotation": "Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SJC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC7#function" }, { "database": "UniProtKB", "id": "ARBA00003451", "url": "https://www.uniprot.org/uniprotkb/ARBA00003451#function" }, { "database": "UniProtKB", "id": "A0AAA9TFL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFL8#function" }, { "database": "UniProtKB", "id": "F1MC73", "url": "https://www.uniprot.org/uniprotkb/F1MC73#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MC73", "url": "https://www.uniprot.org/uniprotkb/F1MC73" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "YDJC", "url": "https://www.uniprot.org/uniprotkb/F1MC73", "locus": { "chromosome": "17", "start_pos": 72126788, "end_pos": 72123850, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013036", "url": "https://www.ensembl.org/id/ENSBTAG00000013036" } ] } } ], "crossref": [ { "id": "F1MC73", "url": "https://alphafold.ebi.ac.uk/entry/F1MC73", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013036", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013036", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10806", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10806", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538763", "url": "https://www.ncbi.nlm.nih.gov/gene/538763", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011330", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011330", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GLHNCDW", "url": "https://omabrowser.org/oma/group/GLHNCDW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MC73", "url": "https://www.orthodb.org/?gene=F1MC73", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31609", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31609", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31609:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31609:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04794", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04794", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005218297", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218297", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SJC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFL8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC73", "url": "https://www.uniprot.org/uniprotkb/F1MC73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC73-1", "url": "https://www.uniprot.org/uniprotkb/F1MC73-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRHFCSRCKSRARGGAGHPACRDPRDRQAARTKAERGRVRRGGASGDVGGGAWTVRSRARTLARPADGGPMARLRVRLVVTADDFGYCPRRDEGIVEAFLAGAVTSVSLLVNGSAAESAAELARRHQIPTGLHANLSEGRPVGPARHGASSLIGSEGFFLGKMGFRRAVAAGEVILPQVREELEAQLSRFRELLGRDPTHVDGHQHVHVLPGVCRVFAEALQACGVRFTRLPLERGVDGCAWLEAPARAFAGAVEQDARAAIGPFVHHGLRWTDVFVGLSTCGRNMSAHRVLEALARALEGVPTGQAVTAELMAHPGYPSVPPLGGCGEGPDAFSCSLDRLHELRVLTAPALRAQLAQDGVQLCTLEDLDGKRPGEGAASRAAREPFVEPSPP", "length": 393, "header": "tr|F1MC73-1|F1MC73_BOVIN Isoform 1 of Carbohydrate deacetylase OS=Bos taurus OX=9913 GN=YDJC PE=3 SV=3 CANONICAL=F1MC73-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC7/entry", "sequence": { "sequence": "DIFAVAASPALGVGRGTRLAGTPGTGRRREQRPSAGACVGAGPRATSGAGPGPSARALEPSRVLRTEAPWPGFACGWWSRQTTLATARGATRALWKPSWPGLSPACPCWSTVRPPRARLNWPAGEWRPSCTVRGGLGDRRPRRRCSLLALRPQAPDPHGPPRQPVRGPPRGPGPPWRLFADRLRGLLPRQDGIPAGGGGWRSDLAPGAQVREELEAQLSRFRELLGRDPTHVDGHQHVHVLPGVCRVFAEALQACGVRFTRLPLERGVDGCAWLEAPARAFAGAVEQDARAAIGPFVHHGLRWTDVFVGLSTCGRNMSAHRVLEALARALEGVPTGQAVTAELMAHPGYPSVPPLGGCGEGPDAFSCSLDRLHELRVLTAPALRAQLAQDGVQLCTLEDLDGKRPGEGAASRAAREPFVEPSPP", "length": 424, "header": "tr|A0AAA9SJC7-1|F1MC73_BOVIN Computationally mapped isoform of Carbohydrate deacetylase OS=Bos taurus OX=9913 GN=YDJC PE=3 SV=1 CANONICAL=F1MC73-1" }, "locus": { "chromosome": "17", "start_pos": 72125784, "end_pos": 72124053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113253.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113253.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084004.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084004.1" } ] } }, { "isoform_ac": "A0AAA9TFL8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFL8/entry", "sequence": { "sequence": "MARLRVRLVVTADDFGYCPRRDEGIVEAFLAGAVTSVSLLVNGSAAESAAELARRHQIPTGLHANLSEGRPVGPARHGASSLIGSEGFFLGKMGFRRAVAAGEVILPQVREELEAQLSRFRELLGRDPTHVDGHQHVHVLPGGPTSSWA", "length": 149, "header": "tr|A0AAA9TFL8-1|F1MC73_BOVIN Computationally mapped isoform of Carbohydrate deacetylase OS=Bos taurus OX=9913 GN=YDJC PE=3 SV=1 CANONICAL=F1MC73-1" }, "locus": { "chromosome": "17", "start_pos": 72125440, "end_pos": 72124259, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108199.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108199.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095651.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095651.1" } ] } }, { "isoform_ac": "F1MC73-1", "url": "https://www.uniprot.org/uniprotkb/F1MC73/entry", "sequence": { "sequence": "MRHFCSRCKSRARGGAGHPACRDPRDRQAARTKAERGRVRRGGASGDVGGGAWTVRSRARTLARPADGGPMARLRVRLVVTADDFGYCPRRDEGIVEAFLAGAVTSVSLLVNGSAAESAAELARRHQIPTGLHANLSEGRPVGPARHGASSLIGSEGFFLGKMGFRRAVAAGEVILPQVREELEAQLSRFRELLGRDPTHVDGHQHVHVLPGVCRVFAEALQACGVRFTRLPLERGVDGCAWLEAPARAFAGAVEQDARAAIGPFVHHGLRWTDVFVGLSTCGRNMSAHRVLEALARALEGVPTGQAVTAELMAHPGYPSVPPLGGCGEGPDAFSCSLDRLHELRVLTAPALRAQLAQDGVQLCTLEDLDGKRPGEGAASRAAREPFVEPSPP", "length": 393, "header": "tr|F1MC73-1|F1MC73_BOVIN Isoform 1 of Carbohydrate deacetylase OS=Bos taurus OX=9913 GN=YDJC PE=3 SV=3 CANONICAL=F1MC73-1" }, "locus": { "chromosome": "17", "start_pos": 72125784, "end_pos": 72124049, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017330.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017330.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017330.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017330.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZX16-1", "protein_name": "Carbohydrate deacetylase", "gene_name": "YDJC", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MFQAKLIVTGDDFGYCPRRNQGIVECFLAGAVSNVSLLVNGSAAADAAKLARRYNIPIGLHANLSEGSPVSEVLKTNSSLLSEAGFFHGKMGFRTALSKGLLNMSEVKQELKAQVDLFHELTGHLPPHMDGHQHVHVLPKVRHVFAEVLEEYGIEYTRVPVEPGLHNCDWIEPSMMDFYVGVEKDSLNTVDVFTKHGIRWPDIYIGLSTMGKNMSVSAIQNAIDTAIVDFTSKVPAHPVPQHRTVTIELMVHPGYPSVPPIGGCGEGPDDFSQSWERLHELQTLIKPELQSHYKTRNIQLCSFKDL", "length": 306 }, "evidence": [ { "id": "F1MC73", "url": "https://omabrowser.org/oma/group/F1MC73/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2BIR6-1", "protein_name": "Carbohydrate deacetylase", "gene_name": "ydjc", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPQPKVKLVVTGDDFGYCERRNQGIVDCFRAGGISNVSLLVNAVSAKHAADLAKRYHMPIGLHANLSEGLPVSQELKGSTLLNKDGFFHGKMGFREVLHSGQLKMSEVEAELRAQVNRFFELIGHMPYHMDGHQHVHVLPDVREVFAQVLSDFGITYTRVPIEPGLRFCNFLPSHLREFNAQVEKDALESVEVFHRNGIRWPDVYLGLSTMGKNMCLSNLKRALEASLDDGVSSPLILTQSNNAASNCYRPVTAELMVHPGYPSQPQQGGCGEGPDDFSQSTDRLHELNTLRDPMVLNFYRQQGIHLCAFKDF", "length": 313 }, "evidence": [ { "id": "F1MC73", "url": "https://omabrowser.org/oma/group/F1MC73/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A8MPS7-1", "protein_name": "Carbohydrate deacetylase", "gene_name": "YDJC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRPRMRLVVTADDFGYCPRRDEGIVEAFLAGAVTSVSLLVNGAATESAAELARRHSIPTGLHANLSEGRPVGPARRGASSLLGPEGFFLGKMGFREAVAAGDVDLPQVREELEAQLSCFRELLGRAPTHADGHQHVHVLPGVCQVFAEALQAYGVRFTRLPLERGVGGCTWLEAPARAFACAVERDARAAVGPFSRHGLRWTDAFVGLSTCGRHMSAHRVSGALARVLEGTLAGHTLTAELMAHPGYPSVPPTGGCGEGPDAFSCSWERLHELRVLTAPTLRAQLAQDGVQLCALDDLDSKRPGEEVPCEPTLEPFLEPSLL", "length": 323 }, "evidence": [ { "id": "F1MC73", "url": "https://omabrowser.org/oma/group/F1MC73/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "F1RKY7-1", "protein_name": "Carbohydrate deacetylase", "gene_name": "YDJC", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGPRVRLVVTADDFGYCPRRDEGIVEAFLAGAVTSVSLLVNGAAAESAAELARRHRIPTGLHANLSEGRPVGPARQGSSSLLSPKGFFLGKMGFREAVAAGDVVLPQVREELEAQLSRFRELLGRDPTHVDGHQHVHVLPGVCQVFAEALQAFGVRFTRLPLERGVGSCTWLEGPARAFACAVEQDARAAIGPFARHGLRWTDAFMGLSTCGRHMSAHRVSGALARALEGIPPRRAVTAELMAHPGYPSVPPAGGCGEGPDAFSCSWERLHELRVLTAPALRARLAQDGVQLCALDDLDSKKSREGKPNEATLETLLEPSSP", "length": 323 }, "evidence": [ { "id": "F1MC73", "url": "https://omabrowser.org/oma/group/F1MC73/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3V683-1", "protein_name": "Carbohydrate deacetylase", "gene_name": "Ydjc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAFPRVRLVVTADDFGYCPRRDEGIVEAFLAGTVTSVSLLVNGTAAESAAELARRHSIPTGLHANLSEGRPVGPARHNASSLLSPEGFFLGKMGFREALAAGDVALPQVREELEAQLSRFRELLGKSPTHVDGHQHVHVLPAGVCQVFAEALQEYGVRFTRLPAERGVGSCAWLEAPARAFACTVERDARAAIGPFSRHGLRWTDAFVGLSTCGRHMSAHRVLGSLARALEDIPAGHALTAELMAHPGYPSVPPAGGCGEGPDAFSCSWERLHELHVLTAPTLRAWLAQNGVQLCAIDDLDSKRPGEGVPL", "length": 311 }, "evidence": [ { "id": "F1MC73", "url": "https://omabrowser.org/oma/group/F1MC73/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14BV6-1", "protein_name": "Carbohydrate deacetylase", "gene_name": "Ydjc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFPRVRLVVTADDFGYCPRRDEGIVEAFLAGTVTSVSLLVNGTAAESAAELARRHSIPTGLHANLSEGRPVGPARHNASSLLSPEGFFLGKMGFREALAAGDVALPQVREELEAQLSRFRELLGRSPTHVDGHQHVHVLPGVCQVFAEALQAYGVRFTRLPAERGVGSCAWLEAPARAFACTVERDARAAIGPFSRHGLRWTDAFVGLSTCGRHMSAHRVLGSLARALEDIPAGHALTAELMAHPGYPSVPPAGGCGEGPDAFSCSWERLHELHVLTAPTLRAWLAQNGVQLCAIDDLDSKRPGEGVPL", "length": 310 }, "evidence": [ { "id": "F1MC73", "url": "https://omabrowser.org/oma/group/F1MC73/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "F1MC73", "url": "https://www.uniprot.org/uniprotkb/F1MC73" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MC73", "url": "https://www.uniprot.org/uniprotkb/F1MC73" } ], "pmid": "" }, { "name": "deacetylase activity", "id": "GO:0019213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019213", "evidence": [ { "database": "UniProtKB", "id": "F1MC73", "url": "https://www.uniprot.org/uniprotkb/F1MC73" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "F1MC73", "url": "https://www.uniprot.org/uniprotkb/F1MC73" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" }, { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MH71-1", "uniprot_ac": "F1MH71", "uniprot_id": "F1MH71_BOVIN", "mass": { "chemical_mass": 120961.0, "monoisotopic_mass": 120961.0 }, "refseq": { "ac": "XP_024852043", "name": "lysine-specific demethylase PHF2 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852043" }, "gene_names": [ { "name": "PHF2", "type": "recommended", "evidence": [ { "id": "F1MH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH71" } ] }, { "name": "PHF2", "type": "synonym", "evidence": [ { "id": "XP_024852043", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852043" } ] } ], "protein_names": [ { "name": "Lysine-specific demethylase PHF2", "type": "recommended", "evidence": [ { "id": "F1MH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH71/entry#names_and_taxonomy" } ] }, { "name": "GRC5", "type": "synonym", "evidence": [ { "id": "F1MH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH71/entry#names_and_taxonomy" } ] }, { "name": "Lysine-specific demethylase phf2", "type": "synonym", "evidence": [ { "id": "F1MH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH71/entry#names_and_taxonomy" } ] }, { "name": "PHD finger protein 2", "type": "synonym", "evidence": [ { "id": "F1MH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH71/entry#names_and_taxonomy" } ] }, { "name": "lysine-specific demethylase PHF2 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_024852043", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852043" } ] } ], "function": [ { "annotation": "Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters.", "evidence": [ { "database": "UniProtKB", "id": "F1MH71", "url": "https://www.uniprot.org/uniprotkb/F1MH71#function" }, { "database": "UniProtKB", "id": "ARBA00053992", "url": "https://www.uniprot.org/uniprotkb/ARBA00053992#function" }, { "database": "UniProtKB", "id": "A0AAA9SP28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP28#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MH71", "url": "https://www.uniprot.org/uniprotkb/F1MH71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PHF2", "url": "https://www.uniprot.org/uniprotkb/F1MH71", "locus": { "chromosome": "8", "start_pos": 84990834, "end_pos": 84898958, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012922", "url": "https://www.ensembl.org/id/ENSBTAG00000012922" } ] } } ], "crossref": [ { "id": "F1MH71", "url": "https://alphafold.ebi.ac.uk/entry/F1MH71", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012922", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012922", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15554", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15554", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537728", "url": "https://www.ncbi.nlm.nih.gov/gene/537728", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041070", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041070", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050690", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050690", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "AWYHILK", "url": "https://omabrowser.org/oma/group/AWYHILK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23123", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23123", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17811", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17811", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3214842", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214842", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024852043", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852043", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "60192", "url": "https://www.rhea-db.org/rhea/60192", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SP28", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SP28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH71", "url": "https://www.uniprot.org/uniprotkb/F1MH71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH71-1", "url": "https://www.uniprot.org/uniprotkb/F1MH71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQTPEVKPVQNGSQLFIKELRSRTFPSAEDVVARVSGSQLTLGYMEEHGFTEPILVPKKEGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNLTNLEFSDTRMSSFVDPPDIVKKLSWVENYWPDDALLAKPKVAKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIKPASANISLYERWQSASNHSEMFFADQVDKCYKCTLKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKSSHKSGKQLPPHLVQGAKILNGAFRSWTRKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKASRPEVTAAVSSDEVCFGDREKEEPPSPIEASPPRSFLEKVSKKKTPKTVKMPKPSKVPKPPKPPKPPKSLKLKDGSKKKGKKCRGSASPTIPNLDLLEAHTKEALTKIEPPKKGKATKNVLSVPNKEVISTQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQKLEKSPLSGNKDTKFSFSFSNKKLLGSKALKPQPGPGVFGALQNFKEDKPQPVRDEYEYVSDDGELKIDEFPIRRKKNAPKRDLSFLLDKKEPLPTPVTKPKLDSALYKQSDDSSDEGSLHIDTDTKPARNAKVKKDSGGSAAGILDLLQASEEVGALEYNPNSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGAGQAKGSSLAAHGARKNGAGGKSAGKRLLKRAAKNSVDLDDYEEEQDHLDACFKDSDYVYPSLESDEDSPVFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSKKKKNTKRKLAPNTTSPSASASAGTTSASTTSASTTSASTTSASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLVDHEYTAAGTFTGAQAGRASQPMAPGVFLTQRRPSSSSPNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL", "length": 1100, "header": "tr|F1MH71-1|F1MH71_BOVIN Isoform 1 of Lysine-specific demethylase PHF2 OS=Bos taurus OX=9913 GN=PHF2 PE=3 SV=3 CANONICAL=F1MH71-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SP28-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SP28/entry", "sequence": { "sequence": "MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSSFPRAPHLGLPRRIWLGEGQQPAWVTGCCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQTPEVKPVQNGSQLFIKELRSRTFPSAEDVVARVSGSQLTLGYMEEHGFTEPILVPKKEGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNLTNLEFSDTRMSSFVDPPDIVKKLSWVENYWPDDALLAKPKVAKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIKPASANISLYERWQSASNHSEMFFADQVDKCYKCTLKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKSSHKSGKQLPPHLVQGAKILNGAFRSWTRKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKASRPEVTAAVSSDEVCFGDREKEEPPSPIEASPPRSFLEKVSKKKTPKTVKMPKPSKVPKPPKPPKPPKSLKLKDGSKKKGKKCRGSASPTIPNLDLLEAHTKEALTKIEPPKKGKATKNVLSVPNKEVISTQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQKLEKSPLSGNKDTKFSFSFSNKKLLGSKALKPQPGPGVFGALQNFKEDKPQPVRDEYEYVSDDGELKIDEFPIRRKKNAPKRDLSFLLDKKEPLPTPVTKPKLDSALYKQSDDSSDEGSLHIDTDTKPARNAKVKKDSGGSAAGILDLLQASEEVGALEYNPNSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGAGQAKGSSLAAHGARKNGAGGKSAGKRLLKRAAKNSVDLDDYEEEQDHLDACFKDSDYVYPSLESDEDSPVFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSKKKKNTKRKLAPNTTSPSASASAGTTSASTTSASTTSASTTSASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLVDHEYTAAGTFTGAQAGRASQPMAPGVFLTQRRPSSSSPNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL", "length": 1128, "header": "tr|A0AAA9SP28-1|F1MH71_BOVIN Computationally mapped isoform of Lysine-specific demethylase PHF2 OS=Bos taurus OX=9913 GN=PHF2 PE=3 SV=1 CANONICAL=F1MH71-1" }, "locus": { "chromosome": "8", "start_pos": 84989830, "end_pos": 84899157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090927.2", "url": "https://www.ensembl.org/id/ENSBTAT00000090927.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085727.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085727.1" } ] } }, { "isoform_ac": "F1MH71-1", "url": "https://www.uniprot.org/uniprotkb/F1MH71/entry", "sequence": { "sequence": "MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQTPEVKPVQNGSQLFIKELRSRTFPSAEDVVARVSGSQLTLGYMEEHGFTEPILVPKKEGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNLTNLEFSDTRMSSFVDPPDIVKKLSWVENYWPDDALLAKPKVAKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIKPASANISLYERWQSASNHSEMFFADQVDKCYKCTLKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKSSHKSGKQLPPHLVQGAKILNGAFRSWTRKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKASRPEVTAAVSSDEVCFGDREKEEPPSPIEASPPRSFLEKVSKKKTPKTVKMPKPSKVPKPPKPPKPPKSLKLKDGSKKKGKKCRGSASPTIPNLDLLEAHTKEALTKIEPPKKGKATKNVLSVPNKEVISTQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQKLEKSPLSGNKDTKFSFSFSNKKLLGSKALKPQPGPGVFGALQNFKEDKPQPVRDEYEYVSDDGELKIDEFPIRRKKNAPKRDLSFLLDKKEPLPTPVTKPKLDSALYKQSDDSSDEGSLHIDTDTKPARNAKVKKDSGGSAAGILDLLQASEEVGALEYNPNSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGAGQAKGSSLAAHGARKNGAGGKSAGKRLLKRAAKNSVDLDDYEEEQDHLDACFKDSDYVYPSLESDEDSPVFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSKKKKNTKRKLAPNTTSPSASASAGTTSASTTSASTTSASTTSASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLVDHEYTAAGTFTGAQAGRASQPMAPGVFLTQRRPSSSSPNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL", "length": 1100, "header": "tr|F1MH71-1|F1MH71_BOVIN Isoform 1 of Lysine-specific demethylase PHF2 OS=Bos taurus OX=9913 GN=PHF2 PE=3 SV=3 CANONICAL=F1MH71-1" }, "locus": { "chromosome": "8", "start_pos": 84989830, "end_pos": 84899157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017171.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017171.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017171.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017171.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 713, "start_aa": "Thr", "end_pos": 713, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr713", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-3214842", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214842", "resource": "Reactome", "description": "HDMs demethylate histones" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZVJ1-1", "protein_name": "Lysine-specific demethylase PHF2", "gene_name": "Phf2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGVRLSGPGRGGRSPCPSHFGVRRKLRPRSCFWLRQGCSGCVHVVRGRGLRGWSLLASRGHPLPRGSPRAQLLAPPGPRAAHLLPRPAFPAAGAGPRPAGGGGATRGADVAAARRPGVPSVGPRLPARHPRASIRFVSRARQGPPRTLSPAPRGPAGGSRRGPSSPRRHCVDAPGRERARGPCRAPPAPSAPAAAPAPAAPAALAARPPARPGPTRAAQRRGERRRGNMATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQTPDMKPVQNGSQLFIKELRSRTFPSAEDVVSRVPGSQLTVGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIRPASANLSLYECWRSASNHSEMFFADQVDKCYKCTVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFRPSQLIKDLAKEIRLSENASKTVRPEVNAVASSDEVCDGDREKEEPPSPIESTPPRSLLEKVSKKKTSKTVKMPKPSKTPKPPKPPKPPKTLKLKDGSKKKGKKCKESASPTIPNLDLLEAHTKEALTKMEPPKKGKTPKSVLSVPNKDTVHTQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLRMEEEQRLEKSPLAGNKDKFSFSFSNRKLLGSKPLRPPSSPGVFGTLQSFKEDKAKPVRDEYEYVSDDGELKIDEFPIRRKKNPPKRDLSFLLDKKETLLIPTSKPKLDSTAYKSDDSSDEGSLHIDTDTKPSRNAKVKKESGSSAAGILDLLQASEEVGALEYNPNSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGTGQAKGGSLAAHGARKNGGSSKGTGKRLLKRTAKNSVDLEDYEEQDHLDACFKDSDYVYPSLESDEDNPVFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKNRKKKNTKRKPTPNTASPSVSTSASASTGTTSASTTPASTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSGLADHEYTAAGTFAGAQAGRASQPMAPGVFLTQRRPSASSPNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL", "length": 1324 }, "evidence": [ { "id": "F1MH71", "url": "https://omabrowser.org/oma/group/F1MH71/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O75151-1", "protein_name": "Lysine-specific demethylase PHF2", "gene_name": "PHF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQAPDVKPVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKAVRPEVNTVASSDEVCDGDREKEEPPSPIEATPPQSLLEKVSKKKTPKTVKMPKPSKIPKPPKPPKPPRPPKTLKLKDGGKKKGKKSRESASPTIPNLDLLEAHTKEALTKMEPPKKGKATKSVLSVPNKDVVHMQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQKLEKSPLAGNKDNKFSFSFSNKKLLGSKALRPPTSPGVFGALQNFKEDKPKPVRDEYEYVSDDGELKIDEFPIRRKKNAPKRDLSFLLDKKAVLPTPVTKPKLDSAAYKSDDSSDEGSLHIDTDTKPGRNARVKKESGSSAAGILDLLQASEEVGALEYNPSSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGAGQAKGSSLAAHGARKNGGGSGKSAGKRLLKRAAKNSVDLDDYEEEQDHLDACFKDSDYVYPSLESDEDNPIFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSKKKKSAKRKLTPNTTSPSTSTSISAGTTSTSTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLADHEYTAAGTFTGAQAGRTSQPMAPGVFLTQRRPSASSPNNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL", "length": 1096 }, "evidence": [ { "id": "F1MH71", "url": "https://omabrowser.org/oma/group/F1MH71/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9WTU0-1", "protein_name": "Lysine-specific demethylase PHF2", "gene_name": "Phf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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{ "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MH71", "url": "https://www.uniprot.org/uniprotkb/F1MH71" } ], "pmid": "" }, { "name": "histone H3K9 demethylase activity", "id": "GO:0032454", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032454", "evidence": [ { "database": "UniProtKB", "id": "F1MH71", "url": "https://www.uniprot.org/uniprotkb/F1MH71" } ], "pmid": "" }, { "name": "histone H3K4me3 reader activity", "id": "GO:0140002", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140002", "evidence": [ { "database": "UniProtKB", "id": "F1MH71", "url": "https://www.uniprot.org/uniprotkb/F1MH71" } ], "pmid": "" }, { "name": "dioxygenase activity", "id": "GO:0051213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051213", "evidence": [ { "database": "UniProtKB", "id": "F1MH71", "url": "https://www.uniprot.org/uniprotkb/F1MH71" } ], "pmid": "" }, { "name": "transcription coregulator 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"categories": [ "Protein Classification" ] }, { "id": "PF02256", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02256", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02906", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02906", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SRG3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRG3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEC7", "url": "https://www.uniprot.org/uniprotkb/F1MEC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEC7-1", "url": "https://www.uniprot.org/uniprotkb/F1MEC7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKCEHCTRKECSKKTKTDDQENASVDVPSPAQENGEKCDTSEHKVLAVSLCPQSLPYFAAKFSLSVTDASRRLCGFLKSLGVHYVFDTTIAADFSILESQKEFVRRFRQHNEEEPALPMLTSACPGWVRYAERVLGHPVTPHLCTAKSPQQIMGSLVKDYFARRQNLSPDKIFHVIVAPCYDKKLEALQEDVLTASRGSRGTDCVLTSGEIAQMMEQSDVSVREAALDTLFGDVKEEELRRHDGAGSDGYLAHIFRHAAKELFNEDVGEVTYRALRNKDFQEVTLEKSGEVLLRFAAAYGFRNIQNVVLKLKKGKFPYHFVEVLACAGGCLNGRGQAQTADGRTDKALLQKMKGIYADIPVQLPEASTHVQELYQEWLDGTDSPRVQEALHTAYQGPGQPADSRDIKW", "length": 408, "header": "tr|F1MEC7-1|F1MEC7_BOVIN Isoform 1 of Nuclear prelamin A recognition factor OS=Bos taurus OX=9913 GN=NARF PE=3 SV=2 CANONICAL=F1MEC7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRG3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRG3/entry", "sequence": { "sequence": "MKCEHCTRKECSKKTKTDDQENASVDVPSPAQENGEKGEFHKLADAKIFLSDCLACDSCVSAEEGIQVSQQNAKDFFQVLNLNKKCDTSEHKVLAVSLCPQSLPYFAAKFSLSVTDASRRLCGFLKSLGVHYVFDTTIAADFSILESQKEFVRRFRQHNEEEPALPMLTSACPGWVRYAERVLGHPVTPHLCTAKSPQQIMGSLVKDYFARRQNLSPDKIFHVIVAPCYDKKLEALQEDVLTASRGSRGTDCVLTSGEIAQMMEQSDVSVREAALDTLFGDVKEEELRRHDGAGSDGYLAHIFRHAAKELFNEDVGEVTYRALRNKDFQEVTLEKSGEVLLRFAAAYGFRNIQNVVLKLKKGCLNGRGQAQTADGRTDKALLQKMKGIYADIPVQLPEASTHVQELYQEWLDGTDSPRVQEALHTAYQGPGQPADSRDIKW", "length": 441, "header": "tr|A0AAA9SRG3-1|F1MEC7_BOVIN Computationally mapped isoform of Nuclear prelamin A recognition factor OS=Bos taurus OX=9913 GN=NARF PE=3 SV=1 CANONICAL=F1MEC7-1" }, "locus": { "chromosome": "19", "start_pos": 50118199, "end_pos": 50101752, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113724.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113724.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086661.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086661.1" } ] } }, { "isoform_ac": "F1MEC7-1", "url": "https://www.uniprot.org/uniprotkb/F1MEC7/entry", "sequence": { "sequence": "MKCEHCTRKECSKKTKTDDQENASVDVPSPAQENGEKCDTSEHKVLAVSLCPQSLPYFAAKFSLSVTDASRRLCGFLKSLGVHYVFDTTIAADFSILESQKEFVRRFRQHNEEEPALPMLTSACPGWVRYAERVLGHPVTPHLCTAKSPQQIMGSLVKDYFARRQNLSPDKIFHVIVAPCYDKKLEALQEDVLTASRGSRGTDCVLTSGEIAQMMEQSDVSVREAALDTLFGDVKEEELRRHDGAGSDGYLAHIFRHAAKELFNEDVGEVTYRALRNKDFQEVTLEKSGEVLLRFAAAYGFRNIQNVVLKLKKGKFPYHFVEVLACAGGCLNGRGQAQTADGRTDKALLQKMKGIYADIPVQLPEASTHVQELYQEWLDGTDSPRVQEALHTAYQGPGQPADSRDIKW", "length": 408, "header": "tr|F1MEC7-1|F1MEC7_BOVIN Isoform 1 of Nuclear prelamin A recognition factor OS=Bos taurus OX=9913 GN=NARF PE=3 SV=2 CANONICAL=F1MEC7-1" }, "locus": { "chromosome": "19", "start_pos": 50118199, "end_pos": 50101752, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024191.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024191.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024191.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024191.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MEC7", "url": "https://www.uniprot.org/uniprotkb/F1MEC7" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1MEC7", "url": "https://www.uniprot.org/uniprotkb/F1MEC7" } ], "pmid": "" }, { "name": "lamin filament", "id": "GO:0005638", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005638", "evidence": [ { "database": "UniProtKB", "id": "F1MEC7", "url": "https://www.uniprot.org/uniprotkb/F1MEC7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lamin binding", "id": "GO:0005521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005521", "evidence": [ { "database": "UniProtKB", "id": "F1MEC7", "url": "https://www.uniprot.org/uniprotkb/F1MEC7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MEC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEC7" }, { "id": "SM00902", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00902" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Iron hydrogenase small subunit", "eco_id": "ECO_0000259", "start_pos": 342, "end_pos": 398, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 166, "end_pos": 168 }, { "start_pos": 22, "end_pos": 24 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MC40-1", "uniprot_ac": "F1MC40", "uniprot_id": "F1MC40_BOVIN", "mass": { "chemical_mass": 138326.0, "monoisotopic_mass": 138326.0 }, "refseq": {}, "gene_names": [ { "name": "FBF1", "type": "recommended", "evidence": [ { "id": "F1MC40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC40" } ] } ], "protein_names": [ { "name": "Fas binding factor 1", "type": "synonym", "evidence": [ { "id": "F1MC40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC40/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MC40", "url": "https://www.uniprot.org/uniprotkb/F1MC40" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBF1", "url": "https://www.uniprot.org/uniprotkb/F1MC40", "locus": { "chromosome": "19", "start_pos": 55716391, "end_pos": 55694918, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030175", "url": "https://www.ensembl.org/id/ENSBTAG00000030175" } ] } } ], "crossref": [ { "id": "F1MC40", "url": "https://alphafold.ebi.ac.uk/entry/F1MC40", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030175", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030175", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR033561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR33689", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33689", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR33689:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33689:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21007", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21007", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9STX4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STX4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TP10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC40", "url": "https://www.uniprot.org/uniprotkb/F1MC40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC40-1", "url": "https://www.uniprot.org/uniprotkb/F1MC40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQV5", "url": "https://www.uniprot.org/uniprotkb/F1MQV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQV5-1", "url": "https://www.uniprot.org/uniprotkb/F1MQV5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPKAKKRVKDSIDDVLGDLLGEEVTPPEKPVKLTSRARDAPGGAQVLPPSGPRPKSLLEDDAFITQAGLAGADAEVSDISDADPQSLLQAMKDLDEMDADLLGLKPSLASNKRPAKGSGKEEPPSPLKIAGVLTANEKDSEDPLAGLLSDDEEGIPKKLPSTETKTSSKKNPAPVRDHGPSIPLTPGDTPVRKKEELLFDDGDDIMATLGFGDSPKAEKRQAGDQEGPLPARSKLDELLGRGPAAKLLARPGTSEHREFKLDKKYQRPQDKEDTWGDEDFTFGAYQPTVGSSEGRQSRRQSVRFLDGGTDPKGEAGSRQSTPAASSPTPPRRGGADWLGLKDDGSDLLPNSPGREARRGPPPASQHSVPVSHPAPAGLPSSSGVKAPAEGTGPPARGSQAAEPGASEEEADEDWLSHALSRKKAQGLARAERTSASEGQHLAGAAGRPRSCSQPAASTQGLEPAAAGEVPGIAAQGPWSPPATSGSPVTWNKAALALHAGDPKRGRAPGDHSGTEPAVVFPNSQEPSGPSVPVQSLARSLLPGSEYQQQLLAAQAELQSGTAELQATLLQNQARLAELEAQVRKLELERTQHKLLLESLQQRHQADLELIECAHRSRVKVLETLYQQREERLRRENEELSAQYLSHCQEAEQARAELTAQHQRRLAAATQEKDQEMERLRELQRASILEMRKDHEEQLQRLKLLKDREIDAVTSATSHTRSLNGIIEQMETFSSSLHELSSRLEASHLSSSQERELGIRQQDKQLQALQERLSQQQRDMEEERSRLQEVIGKMEARLGEQSRLLEQERWRVHAEQSKAEAAQRALEEQRKVMVQQIAMEREELERAKSALLEEQKSVMHKCGEERRRLAAEWAEFFAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAKEDQLAAEREALERERQELRLEKERVSAAAQRIRLRAEEVENMSQVASKKYEDGERALRDARQLQSEQQARLQLVQEQQERLRQQEHHMHQEHLSLAQQRLQLDRVRQDLPSSPVGLLSRAQDPAASGLSATVAPAPAVPRCSQPPVSLGPSHLYAKLVLLKHTAEQWGQEAQAEEGEHSLAPGRAEPTPLPAESSTAGKGQASQTLAVSLREHFLPARLCAEPCEPPLAQPSLAGTVIFSSLQTGQAGPCHVLTRGLPRRESWCVPCPTPSDPEPGRARTSAGRGLIDPLTPRVPSRPVQQSTSLSTEAGAGGSRRAIAHPALPFRTATFWRMNSSSWRP", "length": 1265, "header": "tr|F1MC40-1|F1MC40_BOVIN Isoform 1 of Fas binding factor 1 OS=Bos taurus OX=9913 GN=FBF1 PE=4 SV=5 CANONICAL=F1MC40-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STX4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STX4/entry", "sequence": { "sequence": "MAPKAKKRVKDSIDDVLGDLLGEEVTPPEKPVKLTSRARDAPGGAQVLPPSGPRPKSLLEDDAFITQAGLAGADAEVSDISDADPQSLLQAMKDLDEMDADLLGLKPSLASNKRPAKGSGKEEPPSPLKIAGVLTANEKGDAIPTKKLPPSPSSFGHQYRKFSLEDSEDPLAGLLSDDEEGIPKKLPSTETKTSSKKNPAPVRDHGPSIPLTPGDTPVRKKEELLFDDGDDIMATLGFGDSPKAEKRQAGDQEGPLPARSKLDELLGRGPAAKLLARPGTSEHREFKLDKKYQRPQDKEDTWGDEDFTFGAYQPTVGSSEGRQSRRQSVSRFLDGGTDPKGEAGSRQSTPAASSPTPPRRGGADWLGLKDDGSDLLPNSPGREARRGPPPASQHSVPVSHPAPAGLPSSSGVKAPAEGTGPPARGSQAAEPGASEEEADEDWLSHALSRKKAQGLARAERTSASEGQHLAGAAGRPRSCSQPAASTQGLEPAAAGEVPGIAAQGPWSPPATSGSPVTWNKAALALHAGDPKRGRAPGDHSGTEPAVVFPNSQEPSGPSVPVQSLARSLLPGSEYQQQLLAAQAELQSGTAELQATLLQNQARLAELEAQVRKLELERTQHKLLLESLQQRHQADLELIECAHRSRVKVLETLYQQREERLRRENEELSAQYLSHCQEAEQARAELTAQHQRRLAAATQEKDQEMERLRELQRASILEMRKDHEEQLQRLKLLKDREIDAVTSATSHTRSLNGIIEQMETFSSSLHELSSRLEASHLSSSQERELGIRQQDKQLQALQERLSQQQRDMEEERSRLQEVIGKMEARLGEQSRLLEQERWRVHAEQSKAEAAQRALEEQRKVMVQQIAMEREELERAKSALLEEQKSVMHKCGEERRRLAAEWAEFFAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAKEDQLAAEREALERERQELRLEKERVSAAAQRIRLRAEEVENMSQVASKKYEDGERALRDARQLQSEQQARLQLVQEQQERLRQQEHHMHQEHLSLAQQRLQLDRVRQDLPSSPVGLLSRAQDPAASGLSATVAPAPAVPRCSQPPVSLGPSHLYAKLVLLKHTAEQDRDFLENEQFFLETLKKASYNMASHSA", "length": 1145, "header": "tr|A0AAA9STX4-1|F1MC40_BOVIN Computationally mapped isoform of Fas binding factor 1 OS=Bos taurus OX=9913 GN=FBF1 PE=4 SV=1 CANONICAL=F1MC40-1" }, "locus": { "chromosome": "19", "start_pos": 55715377, "end_pos": 55696336, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111390.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111390.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086555.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086555.1" } ] } }, { "isoform_ac": "A0AAA9TP10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP10/entry", "sequence": { "sequence": "MAPKAKKRVKDSIDDVLGDLLGEEVTPPEKPVKLTSRARDAPGGAQVLPPSGPRPKSLLEDDAFITQAGLAGADAEVSDISDADPQSLLQAMKDLDEMDADLLGLKPSLASNKRPAKGSGKEEPPSPLKIAGVLTANEKGDAIPTKKLPPSPSSFGHQYRKFSLEDSEDPLAGLLSDDEEGIPKKLPSTETKTSSKKNPAPVRDHGPSIPLTPGDTPVRKKEELLFDDGDDIMATLGFGDSPKAEKRQAGDQEGPLPARSKLDELLGRGPAAKLLARPGTSEHREFKLDKKYQRPQDKEDTWGDEDFTFGAYQPTVGSSEGRQSRRQSVRFLDGGTDPKGEAGSRQSTPAASSPTPPRRGGADWLGLKDDGSDLLPNSPGREARRGPPPASQHSVPVSHPAPAGLPSSSGVKAPAEGTGPPARGSQAAEPGASEEEADEDWLSHALSRKKAQGLARAERTSASEGQHLAGAAGRPRSCSQPAASTQGLEPAAAGEVPGIAAQGPWSPPATSGSPVTWNKAALALHAGDPKRGRAPGDHSGTEPAVVFPNSQEPSGPSVPVQSLARSLLPGSEYQQQLLAAQAELQSGTAELQATLLQNQARLAELEAQVRKLELERTQHKLLLESLQQRHQADLELIECAHRSRVKVLETLYQQREERLRRENEELSAQYLSHCQEAEQARAELTAQHQRRLAAATQEKDQEMERLRELQRASILEMRKDHEEQLQRLKLLKDREIDAVTSATSHTRSLNGIIEQMETFSSSLHELSSRLEASHLSSSQERELGIRQQDKQLQALQERLSQQQRDMEEERSRLQEVIGKMEARLGEQSRLLEQERWRVHAEQSKAEAAQRALEEQRKVMVQQIAMEREELERAKSALLEEQKSVMHKCGEERRRLAAEWAEFFAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAKEDQLAAEREALERERQELRLEKERVSAAAQRIRLRAEEVENMSQVASKKYEDGERALRDARQLQSEQQARLQLVQEQQERLRQQEHHMHQEHLSLAQQRLQLDRVRQDLPSSPVGLLSRAQDPAASGLSELDLAAEIP", "length": 1089, "header": "tr|A0AAA9TP10-1|F1MC40_BOVIN Computationally mapped isoform of Fas binding factor 1 OS=Bos taurus OX=9913 GN=FBF1 PE=4 SV=1 CANONICAL=F1MC40-1" }, "locus": { "chromosome": "19", "start_pos": 55714481, "end_pos": 55696336, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098988.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098988.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098082.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098082.1" } ] } }, { "isoform_ac": "F1MC40-1", "url": "https://www.uniprot.org/uniprotkb/F1MC40/entry", "sequence": { "sequence": 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"length": 1265, "header": "tr|F1MC40-1|F1MC40_BOVIN Isoform 1 of Fas binding factor 1 OS=Bos taurus OX=9913 GN=FBF1 PE=4 SV=5 CANONICAL=F1MC40-1" }, "locus": { "chromosome": "19", "start_pos": 55715339, "end_pos": 55696336, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029359.8", "url": "https://www.ensembl.org/id/ENSBTAT00000029359.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029359.8", "url": "https://www.ensembl.org/id/ENSBTAP00000029359.8" } ] } }, { "isoform_ac": "F1MQV5-1", "url": "https://www.uniprot.org/uniprotkb/F1MQV5/entry", "sequence": { "sequence": "MSHGGPFPVPDSIDDVLGDLLGEEVTPPEKPVKLTSRARDAPGGAQVLPPSGPRPKSLLEDDAFITQAGLAGADAEVSDISDADPQSLLQAMKDLDEMDADLLGLKPSLASNKRPAKGSGKEEPPSPLKIAGVLTANEKDSEDPLAGLLSDDEEGIPKKLPSTETKTSSKKNPAPVRDHGPSIPLTPGDTPVRKKEELLFDDGDDIMATLGFGDSPKAEKRQAGDQEGPLPARSKLDELLGRGPAAKLLARPGTSEHREFKLDKKYQRPQDKEDTWGDEDFTFGAYQPTVGSSEGRQSRRQSVSLLGRVRKRWT", "length": 314, "header": "tr|F1MQV5-1|F1MC40_BOVIN Computationally mapped isoform of Fas binding factor 1 OS=Bos taurus OX=9913 GN=FBF1 PE=4 SV=4 CANONICAL=F1MC40-1" }, "locus": { "chromosome": "19", "start_pos": 55705219, "end_pos": 55696336, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000042564.5", "url": "https://www.ensembl.org/id/ENSBTAT00000042564.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040199.5", "url": "https://www.ensembl.org/id/ENSBTAP00000040199.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1194, "start_aa": "Thr", "end_pos": 1194, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1194", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 329, "start_aa": "Thr", "end_pos": 329, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr329", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" } ], "orthologs": [], 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"MRAPALLPPALLTCCGWLLAPVSSVHPECRFHLEIQEEETRCAELLSTQTEKHKACSGIWDNITCWRPADVGETVTVPCPKLFSNFYSKPGNISKNCTSDGWSETFPDFMDACGYSDPEDESKITFYILVKAIYTLGYSVSLISLTTGSIILCLFRKLHCTRNYIHLNLFLSFILRAVSVLVKDDVLYSSSGMLHCLDLPSSWVGCKLSLVFFQYCIMANFYWLLVEGLYLHTLLAVIFAPGRRFRAYLLIGWGIPTVCTGAWTVARLLLEDTGCWDTNDHSVPWWVIRTPILISIIVNFILFVSIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPIRISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQSELRRTWRGLWPSRPSARDYRLHSSSISRTGSDGALQGPRGSRAPSLLQTETSVI", "length": 442, "header": "tr|F1MIT6-1|F1MIT6_BOVIN Isoform 1 of Vasoactive intestinal polypeptide receptor 2 OS=Bos taurus OX=9913 GN=VIPR2 PE=3 SV=3 CANONICAL=F1MIT6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SWJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWJ5/entry", "sequence": { "sequence": "MRAPALLPPALLTCCGWLLAPVSSVHPECRFHLEIQEEETRCAELLSTQTEKHKACSGIWDNITCWRPADVGETVTVPCPKLFSNFYSKPGNISKNCTSDGWSETFPDFMDACGYSDPEDESKITFYILVKAIYTLGYSVSLISLTTGSIILCLFRKLHCTRNYIHLNLFLSFILRAVSVLVKDDVLYSSSGMLHCLDLPSSWVGCKLSLVFFQYCIMANFYWLLVEGLYLHTLLAVIFAPGRRFRAYLLIGWGIPTVCTGAWTVARLLLEDTGCWDTNDHSVPWWVIRTPILISIIVNFILFVSIIRILLQKLTSPDVGGNDQSQYKVQATPHVGLVLNNDSDYLHDQDNHDGVITDLEPDILEWEVKWALESITTNKASGGDGIPVELFQILKDDAVKVLHSICQQIWKTQQWPQDWKRSVFIPVPKKSNAKECSNYHTIALISHASKVMLKILQARLQRYVNHELPNVQAGFRKGRGTRDQIANIRWIIEKAREFQKNIYFCFIDYAKAFDCVDHNKLWKSLIDGNTRPPDLPLEKPICRSGSNS", "length": 548, "header": "tr|A0AAA9SWJ5-1|F1MIT6_BOVIN Computationally mapped isoform of Vasoactive intestinal polypeptide receptor 2 OS=Bos taurus OX=9913 GN=VIPR2 PE=3 SV=1 CANONICAL=F1MIT6-1" }, "locus": { "chromosome": "4", "start_pos": 119695511, "end_pos": 119631586, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098446.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098446.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088430.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088430.1" } ] } }, { "isoform_ac": "F1MIT6-1", "url": "https://www.uniprot.org/uniprotkb/F1MIT6/entry", "sequence": { "sequence": "MRAPALLPPALLTCCGWLLAPVSSVHPECRFHLEIQEEETRCAELLSTQTEKHKACSGIWDNITCWRPADVGETVTVPCPKLFSNFYSKPGNISKNCTSDGWSETFPDFMDACGYSDPEDESKITFYILVKAIYTLGYSVSLISLTTGSIILCLFRKLHCTRNYIHLNLFLSFILRAVSVLVKDDVLYSSSGMLHCLDLPSSWVGCKLSLVFFQYCIMANFYWLLVEGLYLHTLLAVIFAPGRRFRAYLLIGWGIPTVCTGAWTVARLLLEDTGCWDTNDHSVPWWVIRTPILISIIVNFILFVSIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPIRISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQSELRRTWRGLWPSRPSARDYRLHSSSISRTGSDGALQGPRGSRAPSLLQTETSVI", "length": 442, "header": "tr|F1MIT6-1|F1MIT6_BOVIN Isoform 1 of Vasoactive intestinal polypeptide receptor 2 OS=Bos taurus OX=9913 GN=VIPR2 PE=3 SV=3 CANONICAL=F1MIT6-1" }, "locus": { "chromosome": "4", "start_pos": 119695511, "end_pos": 119627565, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047461.4", "url": "https://www.ensembl.org/id/ENSBTAT00000047461.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044668.4", "url": "https://www.ensembl.org/id/ENSBTAP00000044668.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:790124", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:790124", "resource": "KEGG Pathway" }, { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" }, { "id": "R-BTA-420092", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420092", "resource": "Reactome", "description": "Glucagon-type ligand receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AYV5-1", "protein_name": "Vasoactive intestinal polypeptide receptor 2", "gene_name": "VIPR2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRAPALLPPALLTCCGWLLAPVNSIHPECRFHLEIQEEETRCAELLRAPTETYKACSGVWDNITCWRPADVGETVTVPCPKLFSNFYSKPGNISKNCTRDGWSEMFPDFMDACGYSDPEDESKITFYVLVKTIYTLGYSVSLISLTTGSIILCLFRRLHCTRNYIHLNLFLSFILRAVSVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFFQYCIMANFCWLLVEGLYLHTLLVAIFSPSRRFVAYLLIGWGIPTVCTGAWTAARLWLEDTGCWDTNDHSVPWWVIRTPILISIIVNFVLFVSIIRILLQKLTSPDVGGNDQSQYKRLTKSTLLLIPLFGVHYMVFAVFPIKISSKYQILFELCIGSFQGLVVAVLYCFLNSEVQSELRRRWRGLCPSRPSGRDYRLHSSSISRNGSEGALQVPRGSRAPSFLQTETSVI", "length": 442 }, "evidence": [ { "id": "F1MIT6", "url": "https://omabrowser.org/oma/group/F1MIT6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P35000-1", "protein_name": "Vasoactive intestinal polypeptide receptor 2", "gene_name": "Vipr2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRASVVLTCYCWLLVRVSSIHPECRFHLEIQEEETKCAELLSSQMENHRACSGVWDNITCWRPADIGETVTVPCPKVFSNFYSRPGNISKNCTSDGWSETFPDFIDACGYNDPEDESKITFYILVKAIYTLGYSVSLMSLTTGSIIICLFRKLHCTRNYIHLNLFLSFMLRAISVLVKDSVLYSSSGTLRCHDQPGSWVGCKLSLVFFQYCIMANFYWLLVEGLYLHTLLVAILPPSRCFLAYLLIGWGIPSVCIGAWIATRLSLEDTGCWDTNDHSIPWWVIRMPILISIVVNFALFISIVRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAAFPIGISSTYQILFELCVGSFQGLVVAVLYCFLNSEVQCELKRRWRGLCLTQPGSRDYRLHSWSMSRNGSESALQIHRGSRTQSFLQSETSVI", "length": 437 }, "evidence": [ { "id": "F1MIT6", "url": "https://omabrowser.org/oma/group/F1MIT6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P41587-1", "protein_name": "Vasoactive intestinal polypeptide receptor 2", "gene_name": "VIPR2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI", "length": 438 }, "evidence": [ { "id": "F1MIT6", "url": "https://omabrowser.org/oma/group/F1MIT6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P41588-1", "protein_name": "Vasoactive intestinal polypeptide receptor 2", "gene_name": "Vipr2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRASVVLTCYCWLLVRVSSIHPECRFHLEIQEEETKCAELLSSQTENQRACSGVWDNITCWRPADVGETVTVPCPKVFSNFYSRPGNISKNCTSDGWSETFPDFIDACGYNDPEDESKISFYILVKAIYTLGYSVSLMSLTTGSIIICLFRKLHCTRNYIHLNLFLSFMLRAISVLVKDSVLYSSSGLLRCHDQPASWVGCKLSLVFFQYCIMANFYWLLVEGLYLHTLLVAILPPSRCFLAYLLIGWGIPSVCIGAWTATRLSLEDTGCWDTNDHSIPWWVIRMPILISIVVNFALFISIVRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAAFPIGISSTYQILFELCVGSFQGLVVAVLYCFLNSEVQCELKRRWRGLCLTQAGSRDYRLHSWSMSRNGSESALQIHRGSRTQSFLQSETSVI", "length": 437 }, "evidence": [ { "id": "F1MIT6", "url": "https://omabrowser.org/oma/group/F1MIT6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "pituitary adenylate cyclase-activating polypeptide receptor activity", "id": "GO:0001634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001634", "evidence": [ { "database": "UniProtKB", "id": "F1MIT6", "url": "https://www.uniprot.org/uniprotkb/F1MIT6" } ], "pmid": "" }, { "name": "vasoactive intestinal polypeptide receptor activity", "id": "GO:0004999", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004999", "evidence": [ { "database": "UniProtKB", "id": "F1MIT6", "url": "https://www.uniprot.org/uniprotkb/F1MIT6" } ], "pmid": "" }, { "name": "peptide hormone binding", "id": "GO:0017046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017046", "evidence": [ { "database": "UniProtKB", "id": "F1MIT6", "url": "https://www.uniprot.org/uniprotkb/F1MIT6" } ], "pmid": "" }, { "name": "G protein-coupled peptide receptor activity", "id": "GO:0008528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008528", "evidence": [ { "database": "UniProtKB", "id": "F1MIT6", "url": "https://www.uniprot.org/uniprotkb/F1MIT6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MIT6", "url": "https://www.uniprot.org/uniprotkb/F1MIT6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "F1MIT6", "url": "https://www.uniprot.org/uniprotkb/F1MIT6" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "F1MIT6", "url": "https://www.uniprot.org/uniprotkb/F1MIT6" } ], "pmid": "" }, { "name": "adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "id": "GO:0007188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007188", "evidence": [ { "database": "UniProtKB", "id": "F1MIT6", "url": "https://www.uniprot.org/uniprotkb/F1MIT6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIT6" }, { "id": "PS50227", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50227" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 2 profile 1", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 117, "start_aa": "Arg", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIT6" }, { "id": "PS50261", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50261" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 2 profile 2", "eco_id": "ECO_0000259", "start_pos": 130, "end_pos": 383, "start_aa": "Val", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 62, "end_pos": 64 }, { "start_pos": 92, "end_pos": 94 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 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"strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002368", "url": "https://www.ensembl.org/id/ENSBTAG00000002368" } ] } } ], "crossref": [ { "id": "F1MIY1", "url": "https://alphafold.ebi.ac.uk/entry/F1MIY1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002368", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002368", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025659", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025659", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MIY1", "url": "https://www.orthodb.org/?gene=F1MIY1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16517", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16517", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16517:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16517:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01167", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01167", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16322", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16322", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SYT9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYT9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYT9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIY1", "url": "https://www.uniprot.org/uniprotkb/F1MIY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIY1-1", "url": "https://www.uniprot.org/uniprotkb/F1MIY1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRESDTWKKEALGDELAAMRLQKLEQQWRLFEKKQRRKRQEPLMVQANPDASVRPRRPRRREERFSADSGPRNPFLQENVPEAHLCPGSHGILGTVSCGGDGSGERDPLLPPTEAVFKNPSLQFSSLSLPGSSDLELEEVSVEDVPASPPPCEEPPGTLLQRKGWPARQRSGASAEDKSELQDVGIEYEVPSARSSPGMDGDGGLGDLASNKGEDLEEKKEEPEFTMRKSPGTADEVVSEGARGAGSGDVGNSPRTPPCAPGPRLGEDMRAYVLRPAMRGRTVQCRISRDKRGVDKGMFPFYYLYLEAADGLKHFLLAGRKRKRSKTSNYLISLDPTDLSRDGDNFVGKVRSNVLGTKFSIFDNGVNPERKHFFPETARIREELGAVCYETNVLGFRGPRKMNVIIPEINAQNQRICVQPQNEQESLLSRLQRGASQGLVLLQNKAPSWNDESGAYVLNFHGRVTRASVKNFQIVHPDDPDYLVLQFGRVAPDTFTMDFRFPLCPLQAFAICLSSFDGKLACE", "length": 524, "header": "tr|F1MIY1-1|F1MIY1_BOVIN Isoform 1 of Tubby-like protein OS=Bos taurus OX=9913 GN=TULP2 PE=3 SV=4 CANONICAL=F1MIY1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYT9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYT9/entry", "sequence": { "sequence": "MEVVVFSFIFSPGRGCKLQIDSSWHRSHYNFLIPRDYVPGFQREGQLCLEIGQTGKELRCECEKFLQVGEEVSRIPGRMSRESDTWKKEALGDELAAMRLQKLEQQWRLFEKKQRRKRQEPLMVQANPDASVRPRRPRRREERFSADSGPRNPFLQENVPEAHLCPGSHGILGTVSCGGDGSGERDPLLPPTEAGSSDLELEEVSVEDVPASPPPCEEPPGTLLQRKGWPARQRSGASAEDKSELQDVGIEYEVPSARSSPGMDGDGGLGDLASNKGEDLEEKKEEPEFTMRKSPGTADEVVSEGARGAGSGDVGNSPRTPPCAPGPRLGEDMRAYVLRPAMRGRTVQCRISRDKRGVDKGMFPFYYLYLEAADGLKHFLLAGRKRKRSKTSNYLISLDPTDLSRDGDNFVGKVRSNVLGTKFSIFDNGVNPERKHFFPETARIREELGAVCYETNVLGFRGPRKMNVIIPEINAQNQRICVQPQNEQESLLSRLQRGASQGLVLLQNKAPSWNDESGAYVLNFHGRVTRASVKNFQIVHPDDRELLGNGLPWQGGRRKSTSPIST", "length": 566, "header": "tr|A0AAA9SYT9-1|F1MIY1_BOVIN Computationally mapped isoform of Tubby-like protein OS=Bos taurus OX=9913 GN=TULP2 PE=3 SV=1 CANONICAL=F1MIY1-1" }, "locus": { "chromosome": "18", "start_pos": 55487147, "end_pos": 55479294, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102248.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102248.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089260.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089260.1" } ] } }, { "isoform_ac": "A0AAA9TZM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZM9/entry", "sequence": { "sequence": "MSRESDTWKKEALGDELAAMRLQKLEQQWRLFEKKQRRKRQEPLMVQANPDASVRPRRPRRREERFSADSVFKNPSLQFSSLSLPGSSDLELEEVSVEDVPASPPPCEEPPGTLLQRKGWPARQRSGASAEDKSELQDVGIEYEVPSARSSPGMDGDGGLGDLASNKGEDLEEKKEEPEFTMRKSPGTADEVVSEGARGAGSGDVGNSPRTPPCAPGPRLGEDMRAYVLRPAMRGRTVQCRISRDKRGVDKGMFPFYYLYLEAADGLKHFLLAGRKRKRSKTSNYLISLDPTDLSRDGDNFVGKVRSNVLGTKFSIFDNGVNPERKHFFPETARIREELGAVCYETNVLGFRGPRKMNVIIPEINAQNQRICVQPQNEQESLLSRLQRGASQGLVLLQNKAPSWNDESGAYVLNFHGRVTRASVKNFQIVHPDDPDYLVLQFGRVAPDTFTMDFRFPLCPLQAFAICLSSFDGKLACE", "length": 478, "header": "tr|A0AAA9TZM9-1|F1MIY1_BOVIN Computationally mapped isoform of Tubby-like protein OS=Bos taurus OX=9913 GN=TULP2 PE=3 SV=1 CANONICAL=F1MIY1-1" }, "locus": { "chromosome": "18", "start_pos": 55486380, "end_pos": 55478744, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114116.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114116.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102740.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102740.1" } ] } }, { "isoform_ac": "F1MIY1-1", "url": "https://www.uniprot.org/uniprotkb/F1MIY1/entry", "sequence": { "sequence": "MSRESDTWKKEALGDELAAMRLQKLEQQWRLFEKKQRRKRQEPLMVQANPDASVRPRRPRRREERFSADSGPRNPFLQENVPEAHLCPGSHGILGTVSCGGDGSGERDPLLPPTEAVFKNPSLQFSSLSLPGSSDLELEEVSVEDVPASPPPCEEPPGTLLQRKGWPARQRSGASAEDKSELQDVGIEYEVPSARSSPGMDGDGGLGDLASNKGEDLEEKKEEPEFTMRKSPGTADEVVSEGARGAGSGDVGNSPRTPPCAPGPRLGEDMRAYVLRPAMRGRTVQCRISRDKRGVDKGMFPFYYLYLEAADGLKHFLLAGRKRKRSKTSNYLISLDPTDLSRDGDNFVGKVRSNVLGTKFSIFDNGVNPERKHFFPETARIREELGAVCYETNVLGFRGPRKMNVIIPEINAQNQRICVQPQNEQESLLSRLQRGASQGLVLLQNKAPSWNDESGAYVLNFHGRVTRASVKNFQIVHPDDPDYLVLQFGRVAPDTFTMDFRFPLCPLQAFAICLSSFDGKLACE", "length": 524, "header": "tr|F1MIY1-1|F1MIY1_BOVIN Isoform 1 of Tubby-like protein OS=Bos taurus OX=9913 GN=TULP2 PE=3 SV=4 CANONICAL=F1MIY1-1" }, "locus": { "chromosome": "18", "start_pos": 55486380, "end_pos": 55478744, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006390.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006390.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006390.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006390.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MIY1", "url": "https://www.uniprot.org/uniprotkb/F1MIY1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MIY1", "url": "https://www.uniprot.org/uniprotkb/F1MIY1" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "F1MIY1", "url": "https://www.uniprot.org/uniprotkb/F1MIY1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "F1MIY1", "url": "https://www.uniprot.org/uniprotkb/F1MIY1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein localization to cilium", "id": "GO:0061512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061512", "evidence": [ { "database": "UniProtKB", "id": "F1MIY1", "url": "https://www.uniprot.org/uniprotkb/F1MIY1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MIY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIY1" }, { "id": "PF01167", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01167" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tubby C-terminal", "eco_id": "ECO_0000259", "start_pos": 275, "end_pos": 518, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MIY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIY1" }, { "id": "PF16322", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16322" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tubby N-terminal", "eco_id": "ECO_0000259", "start_pos": 27, "end_pos": 256, "start_aa": "Gln", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MHJ5-1", "uniprot_ac": "F1MHJ5", "uniprot_id": "F1MHJ5_BOVIN", "mass": { "chemical_mass": 46323.0, "monoisotopic_mass": 46323.0 }, "refseq": {}, "gene_names": [ { "name": "SNX6", "type": "recommended", "evidence": [ { "id": "F1MHJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ] } ], "protein_names": [ { "name": "Sorting nexin", "type": "recommended", "evidence": [ { "id": "F1MHJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in several stages of intracellular trafficking.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TA46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA46#function" }, { "database": "UniProtKB", "id": "PIRNR036924", "url": "https://www.uniprot.org/uniprotkb/PIRNR036924#function" }, { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNX6", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5", "locus": { "chromosome": "21", "start_pos": 44998870, "end_pos": 45096344, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012873", "url": "https://www.ensembl.org/id/ENSBTAG00000012873" } ] } } ], "crossref": [ { "id": "F1MHJ5", "url": "https://alphafold.ebi.ac.uk/entry/F1MHJ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012873", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012873", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07292", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07292", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07662", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07662", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014637", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014637", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028657", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028657", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45850", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45850", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45850:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45850:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09325", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09325", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TA46", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM33", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM33", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM33-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHJ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLEESWNISLHTKLKAINVDLQSDAALQVDISDALSERDKVKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFIENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRKDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT", "length": 402, "header": "tr|F1MHJ5-1|F1MHJ5_BOVIN Isoform 1 of Sorting nexin OS=Bos taurus OX=9913 GN=SNX6 PE=3 SV=4 CANONICAL=F1MHJ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TA46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA46/entry", "sequence": { "sequence": "VRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDKVKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFIENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRKDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT", "length": 418, "header": "tr|A0AAA9TA46-1|F1MHJ5_BOVIN Computationally mapped isoform of Sorting nexin OS=Bos taurus OX=9913 GN=SNX6 PE=3 SV=1 CANONICAL=F1MHJ5-1" }, "locus": { "chromosome": "21", "start_pos": 45046881, "end_pos": 44999510, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118927.2", "url": 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"strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122911.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122911.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101200.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101200.1" } ] } }, { "isoform_ac": "A0AAF6DM33-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM33/entry", "sequence": { "sequence": "PQEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDKVKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFIENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRKDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKMHSEF", "length": 244, "header": "tr|A0AAF6DM33-1|F1MHJ5_BOVIN Computationally mapped isoform of Sorting nexin OS=Bos taurus OX=9913 GN=SNX6 PE=3 SV=1 CANONICAL=F1MHJ5-1" }, "locus": { "chromosome": "21", "start_pos": 45046691, "end_pos": 45019881, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024786.5", "url": "https://www.ensembl.org/id/ENSBTAT00000024786.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024786.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024786.5" } ] } }, { "isoform_ac": "F1MHJ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5/entry", "sequence": { "sequence": "MLLEESWNISLHTKLKAINVDLQSDAALQVDISDALSERDKVKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFIENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRKDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT", "length": 402, "header": "tr|F1MHJ5-1|F1MHJ5_BOVIN Isoform 1 of Sorting nexin OS=Bos taurus OX=9913 GN=SNX6 PE=3 SV=4 CANONICAL=F1MHJ5-1" }, "locus": { "chromosome": "21", "start_pos": 45053430, "end_pos": 44999510, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017106.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017106.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017106.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017106.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "tubular endosome", "id": "GO:0097422", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097422", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "retromer complex", "id": "GO:0030904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030904", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "postsynaptic early endosome", "id": "GO:0098842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098842", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "cellular response to amyloid-beta", "id": "GO:1904646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904646", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "negative regulation of neuron apoptotic process", "id": "GO:0043524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043524", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "negative regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030512", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "regulation of postsynaptic membrane neurotransmitter receptor levels", "id": "GO:0099072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099072", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "dynactin binding", "id": "GO:0034452", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034452", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" }, { "name": "type I transforming growth factor beta receptor binding", "id": "GO:0034713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034713", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ5", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 8, "end_pos": 10, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MHJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHJ5" }, { "id": "PS50195", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50195" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PX", "eco_id": "ECO_0000259", "start_pos": 22, "end_pos": 169, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 8, "end_pos": 10 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536281", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536281", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YSSLYYE", "url": "https://omabrowser.org/oma/group/YSSLYYE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MC84", "url": "https://www.orthodb.org/?gene=F1MC84", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24025", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24025", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24025:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24025:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24027:SF423", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24027:SF423", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02210", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02210", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193811", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TMT1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMT1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMT1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMT1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC84", "url": "https://www.uniprot.org/uniprotkb/F1MC84", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC84-1", "url": "https://www.uniprot.org/uniprotkb/F1MC84-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLTMGYCVGTRPPSCLILLLLKLLATLSQGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDLEAWTKVSIQVLDMNDLRPLFSPTTYSVTIAENTALRTSVAQVTATDADIGSNGEFYYYFKNKVELFSVHPTSGVISLSGRLNYDEKSRYDLEILAVDRGMKLYGNNGVSSTAKLYVHVERVNEHAPALHVVTHIPFSLDTEPVYAVVTADDLDEGANGEIESVSIVAGDPLDQFFLAKEGKWVNEYRVKEKKPVDWESFPYGYNLTLQAKDKGSPQKFSAVKIVHIANPKRDTVPIRFEKDAYEVSISEFSPPGVVVAIVKLSPEPLDVEYRLSPGEDAQYFKINPQSGLIVTAQPLNTIKKEVYRLGVTNKEGDLKTQVTISIEDANDHTPEFQQLLYEAFVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNVLPFAINQFTGVISTTEDLDFESSPETYRFIVRASDWGSPYRHESEVNVTIRVGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSGIKNGNFALRITATDGENLADPMSVNISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSVNRQGPHFDKSFPSDVAVKENLPVGANILKIKAYDADSGFNGKVLFTISDGNMDSCFNIDMETGQLQVLMPMDREHRDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPIFLQDSYSVNILESSSIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYIADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSRELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVISTADILDRETTGSYWLTVYATDRGVVPLYSTIEVYIEIEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSSEKLTYRITSGNPQNFFAINVKTGLITTTSRKLDREQQAEHFLEVTVTDGGFSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGRFFIDPKTGMVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPVPLTFDEPFYNFTVMENDRVTEIVGVVSVQPANTLLWFDIVGGNFDSSFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILHIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELMYTIEAGNTGNTFKIEPVLGIITVSKEPDMTTMGQFVLSVKVTDQGSPPMSATAIVRISVTMSDNSNPRFTHKDYQAEVNENVDVGTSVILISAISQSTLIYEVKDGNVDGIFTINPYSGVITTRKALDYERTSSYQLIVQATNMAGMASNVTVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIASLDHEAIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSAVDPDSEIPPELTYSLMEGSLDHFLIDSNSGVLTVKNNNLSKDHYMLIVKVSDGKFYSTSMVTILVKEAMDSGLHFTQNFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVSIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILARDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIAMDTPILSINATSPEGQGIIYIIIDGDLYKQFNIDFDTGVLKVISPLDYEMTSVYKLTVRASDALTGARAEVTIDLLVNDVNDNPPIFGQPTYNTTLSEASLIGTPVLQVVSTDADSGNNKMVHYQIVQDTYNSTDYFHIDSASGLILTARMLDHESVQHCTLKVRATDNGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGIITLSNHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENAAAGTKVIHVRATDGDPGMYGQISYAIINDFAKDRFLIDGNGQVTTTERLDRENPLEGDISIFLRALDGGGRTTFCTVRVIVVDENDNAPQFLTVEYRASVRADVGRGHLVTQVQAMDPDDGANARITYSLYSEASVSVADLLEIDPDNGWMVTKGHFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETSVPSFTQSQYSFTVSEDTAIGSTVDTLRILPTQKVTFSTVNGERLENNKGNVFIIEQETGTIKLDKRLDHEVSPAFHFKVAATMPLDKVDAVFTVDVDVKVLDLNDNKPVFETSNYETIIMEGMPVGTKLTQVRAMDVDWGANGQVTYSLHSDSQPEKVMEAFSIDSNTGWISTLKDLDHETDPMFTFSVVASDLGEAFSLSSTALVSVRVTDINDNTPVFAHEVYRGNVKESDPPGEVVAVLSTWDRDTSDINRQVSYHITGGNPRGRFALGLVQSEWKVYVKRHLDREEQDIYFLNITATDGLFVTQAMVEVTVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGPNGDIRYSLYGPGNNEFFLDPESGELKTLAPLDRERVPAYSLVARATDGGGRFCQSDLRLTLEDVNDNPPVFSSDHYNACVYENTATKALLTRVQAVDPDVGVNRKVVYSLADSANGFFSVDSSSGIVVLERPLDREQQSSYTLRVQATDQSPGRALSSLATISITVLDVNDNPPVFERRDYLVSVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFRINPKTGGISVSEALDYELCRKFYLMVEAKDGGTPALSAVTTVGINLTDVNDNPPEFSQDVYSAVISEDALVGDSVILLIAEDADSQPNGQIRFSIVNGDRDNEFAVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGMPAMSSTATVNIDISDVNDNSPVFTPANATAVIQENKPVGTSVLQLMVTDKDSFHNGPPFSFSILSGNEEEAFVLDSDGILRSAVVFQHTESPEYVLCVQAKDSGKPQQVSHSYVRVRVIEESIHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDVLTFALKSEQKSLFKVNSHDGKIIALGGLDSGKYVLNVSVSDGRFQVPIDVVVHVEQLVQEMLQNTVTIRFENVSPEDFVGLHMHGFRRTLRNAVLTQKQDSLHIISIQPVAGTSELDMLFAVETHSSEFYKPAYLIQKLSNARRHLENAMRISAILEKNCSGLDCQEQHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTCDGGLCPGANDPCVEKPCPGDMQCVGYEASRRPFLCQCPPGKLGECSGHTSLSFAGNSYIKYRLSENSKEEDFKLALRLRTLQSNGIIMYTRANPCIILKIVDGRLWFQLDCGSGPGILGISGRAVNDGSWHSVFLELNRNFTSLALDDSYVERRRAPLYFQTLGTDSAIYFGALVQADSIRSLTDARVTQVLSGFQGCLDSVVLNNNELPLQNKRSSFAEVVGLTELKLGCVLYPDACERGPCQHGGSCAGLASGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSCDPIGNTFICSCKAGLTGVTCEEDVNECEREECENGGACVNVFGSFVCNCTPGYVGQYCGLRPVVVPNIQAGHAYVGREELIGIAAVLLVIVALIVLFVVFRKKVFRKSYSRNNITLVQDPATAALLRKSNGVPFRSLRAGDGRHAYQEAGPPQVPVRPMAYTPCFQGDSRSNLDKIGDGLGGEPQEMTTFHPESPRILTARRGVVVCSVAPNLPAVSPCRSDCDSIRKNGWDAGTENKGVDDPGEVTCFAGSNKGSNSEVQSLSSFQSDSGDDNAYHWDTSDWMPGARLSDIEEVPTYESQEGAAPPGSARGLESDYYLGGYDVDSEYPPPHDDDFLGQDPLPPPLPEDFADQYDGLPPARPGSLAGTLSPGCRRRPQFHPSQYLPPHPFPHETDVGGPPAAGEFSTFAVSVNPGAEAAAGPADGVALSLHNSRGPSSSDVSASCGFDDSEVAVSDYESVGELSLASLHIPFLETQQQTQV", "length": 4555, "header": "tr|F1MC84-1|F1MC84_BOVIN Isoform 1 of Protocadherin Fat 3 OS=Bos taurus OX=9913 GN=FAT3 PE=4 SV=3 CANONICAL=F1MC84-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TMT1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMT1/entry", "sequence": { "sequence": "MDLTMGYCVGTRPPSCLILLLLKLLATLSQGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDLEAWTKVSIQVLDMNDLRPLFSPTTYSVTIAENTALRTSVAQVTATDADIGSNGEFYYYFKNKVELFSVHPTSGVISLSGRLNYDEKSRYDLEILAVDRGMKLYGNNGVSSTAKLYVHVERVNEHAPALHVVTHIPFSLDTEPVYAVVTADDLDEGANGEIESVSIVAGDPLDQFFLAKEGKWVNEYRVKEKKPVDWESFPYGYNLTLQAKDKGSPQKFSAVKIVHIANPKRDTVPIRFEKDAYEVSISEFSPPGVVVAIVKLSPEPLDVEYRLSPGEDAQYFKINPQSGLIVTAQPLNTIKKEVYRLGVTNKEGDLKTQVTISIEDANDHTPEFQQLLYEAFVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNVLPFAINQFTGVISTTEDLDFESSPETYRFIVRASDWGSPYRHESEVNVTIRVGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSGIKNGNFALRITATDGENLADPMSVNISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSVNRQGPHFDKSFPSDVAVKENLPVGANILKIKAYDADSGFNGKVLFTISDGNMDSCFNIDMETGQLQVLMPMDREHRDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPIFLQDSYSVNILESSSIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYIADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSRELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVISTADILDRETTGSYWLTVYATDRGVVPLYSTIEVYIEIEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSSEKLTYRITSGNPQNFFAINVKTGLITTTSRKLDREQQAEHFLEVTVTDGGFSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGRFFIDPKTGMVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPVPLTFDEPFYNFTVMENDRVTEIVGVVSVQPANTLLWFDIVGGNFDSSFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILHIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELMYTIEAGNTGNTFKIEPVLGIITVSKEPDMTTMGQFVLSVKVTDQGSPPMSATAIVRISVTMSDNSNPRFTHKDYQAEVNENVDVGTSVILISAISQSTLIYEVKDGNVDGIFTINPYSGVITTRKALDYERTSSYQLIVQATNMAGMASNVTVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIASLDHEAIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSAVDPDSEIPPELTYSLMEGSLDHFLIDSNSGVLTVKNNNLSKDHYMLIVKVSDGKFYSTSMVTILVKEAMDSGLHFTQNFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVSIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILARDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIAMDTPILSINATSPEGQGIIYIIIDGDLYKQFNIDFDTGVLKVISPLDYEMTSVYKLTVRASDALTGARAEVTIDLLVNDVNDNPPIFGQPTYNTTLSEASLIGTPVLQVVSTDADSGNNKMVHYQIVQDTYNSTDYFHIDSASGLILTARMLDHESVQHCTLKVRATDNGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGIITLSNHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENAAAGTKVIHVRATDGDPGMYGQISYAIINDFAKDRFLIDGNGQVTTTERLDRENPLEGDISIFLRALDGGGRTTFCTVRVIVVDENDNAPQFLTVEYRASVRADVGRGHLVTQVQAMDPDDGANARITYSLYSEASVSVADLLEIDPDNGWMVTKGHFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETSVPSFTQSQYSFTVSEDTAIGSTVDTLRILPTQKVTFSTVNGERLENNKGNVFIIEQETGTIKLDKRLDHEVSPAFHFKVAATMPLDKVDAVFTVDVDVKVLDLNDNKPVFETSNYETIIMEGMPVGTKLTQVRAMDVDWGANGQVTYSLHSDSQPEKVMEAFSIDSNTGWISTLKDLDHETDPMFTFSVVASDLGEAFSLSSTALVSVRVTDINDNTPVFAHEVYRGNVKESDPPGEVVAVLSTWDRDTSDINRQVSYHITGGNPRGRFALGLVQSEWKVYVKRHLDREEQDIYFLNITATDGLFVTQAMVEVTVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGPNGDIRYSLYGPGNNEFFLDPESGELKTLAPLDRERVPAYSLVARATDGGGRFCQSDLRLTLEDVNDNPPVFSSDHYNACVYENTATKALLTRVQAVDPDVGVNRKVVYSLADSANGFFSVDSSSGIVVLERPLDREQQSSYTLRVQATDQSPGRALSSLATISITVLDVNDNPPVFERRDYLVSVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFRINPKTGGISVSEALDYELCRKFYLMVEAKDGGTPALSAVTTVGINLTDVNDNPPEFSQDVYSAVISEDALVGDSVILLIAEDADSQPNGQIRFSIVNGDRDNEFAVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGMPAMSSTATVNIDISDVNDNSPVFTPANATAVIQENKPVGTSVLQLMVTDKDSFHNGPPFSFSILSGNEEEAFVLDSDGILRSAVVFQHTESPEYVLCVQAKDSGKPQQVSHSYVRVRVIEESIHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDVLTFALKSEQKSLFKVNSHDGKIIALGGLDSGKYVLNVSVSDGRFQVPIDVVVHVEQLVQEMLQNTVTIRFENVSPEDFVGLHMHGFRRTLRNAVLTQKQDSLHIISIQPVAGTSELDMLFAVETHSSEFYKPAYLIQKLSNARRHLENAMRISAILEKNCSGLDCQEQHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTCDGGLCPGANDPCVEKPCPGDMQCVGYEASRRPFLCQCPPGKLGECSGHTSLSFAGNSYIKYRLSENSKEEDFKLALRLRTLQSNGIIMYTRANPCIILKIVDGRLWFQLDCGSGPGILGISGRAVNDGSWHSVFLELNRNFTSLALDDSYVERRRAPLYFQTLGTDSAIYFGALVQADSIRSLTDARVTQVLSGFQGCLDSVVLNNNELPLQNKRSSFAEVVGLTELKLGCVLYPDACERGPCQHGGSCAGLASGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSCDPIGNTFICSCKAGLTGVTCEEDVNECEREECENGGACVNVFGSFVCNCTPGYVGQYCGLRPVVVPNIQAGHAYVGREELIGIAAVLLVIVALIVLFVVFRKKVFRKSYSRNNITLVQDPATAALLRKSNGVPFRSLRAGDGRHAYQEAGPPQVPVRPMAYTPCFQGDSRSNLDKIGDGLGGEPQEMTTFHPESPRILTARRGVVVCSVAPNLPAVSPCRSDCDSIRKNGWDAGTENKGVDDPGEVTCFAGSNKGSNSEVQSLSSFQSDSGDDNASIVTVIQLVNNVVDTIENEVSVMDQGQNFNRAYHWDTSDWMPGARLSDIEEVPTYESQEGAAPPGSARGLESDYYLGGYDVDSEYPPPHDDDFLGQDPLPPPLPEDFADQYDGLPPARPGSLAGTLSPGCRRRPQFHPSQYLPPHPFPHETDVGGPPAAGEFSTFAVSVNPGAEAAAGPADGVALSLHNSRGPSSSDVSASCGFDDSEVAVSDYESVGELSLASLHIPFLETQQQTQV", "length": 4587, "header": "tr|A0AAA9TMT1-1|F1MC84_BOVIN Computationally mapped isoform of Protocadherin Fat 3 OS=Bos taurus OX=9913 GN=FAT3 PE=4 SV=1 CANONICAL=F1MC84-1" }, "locus": { "chromosome": "29", "start_pos": 2635494, "end_pos": 1996707, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129558.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129558.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099825.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099825.1" } ] } }, { "isoform_ac": "F1MC84-1", "url": "https://www.uniprot.org/uniprotkb/F1MC84/entry", "sequence": { "sequence": "MDLTMGYCVGTRPPSCLILLLLKLLATLSQGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDLEAWTKVSIQVLDMNDLRPLFSPTTYSVTIAENTALRTSVAQVTATDADIGSNGEFYYYFKNKVELFSVHPTSGVISLSGRLNYDEKSRYDLEILAVDRGMKLYGNNGVSSTAKLYVHVERVNEHAPALHVVTHIPFSLDTEPVYAVVTADDLDEGANGEIESVSIVAGDPLDQFFLAKEGKWVNEYRVKEKKPVDWESFPYGYNLTLQAKDKGSPQKFSAVKIVHIANPKRDTVPIRFEKDAYEVSISEFSPPGVVVAIVKLSPEPLDVEYRLSPGEDAQYFKINPQSGLIVTAQPLNTIKKEVYRLGVTNKEGDLKTQVTISIEDANDHTPEFQQLLYEAFVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNVLPFAINQFTGVISTTEDLDFESSPETYRFIVRASDWGSPYRHESEVNVTIRVGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSGIKNGNFALRITATDGENLADPMSVNISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSVNRQGPHFDKSFPSDVAVKENLPVGANILKIKAYDADSGFNGKVLFTISDGNMDSCFNIDMETGQLQVLMPMDREHRDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPIFLQDSYSVNILESSSIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYIADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSRELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVISTADILDRETTGSYWLTVYATDRGVVPLYSTIEVYIEIEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSSEKLTYRITSGNPQNFFAINVKTGLITTTSRKLDREQQAEHFLEVTVTDGGFSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGRFFIDPKTGMVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPVPLTFDEPFYNFTVMENDRVTEIVGVVSVQPANTLLWFDIVGGNFDSSFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILHIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELMYTIEAGNTGNTFKIEPVLGIITVSKEPDMTTMGQFVLSVKVTDQGSPPMSATAIVRISVTMSDNSNPRFTHKDYQAEVNENVDVGTSVILISAISQSTLIYEVKDGNVDGIFTINPYSGVITTRKALDYERTSSYQLIVQATNMAGMASNVTVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIASLDHEAIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSAVDPDSEIPPELTYSLMEGSLDHFLIDSNSGVLTVKNNNLSKDHYMLIVKVSDGKFYSTSMVTILVKEAMDSGLHFTQNFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVSIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILARDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIAMDTPILSINATSPEGQGIIYIIIDGDLYKQFNIDFDTGVLKVISPLDYEMTSVYKLTVRASDALTGARAEVTIDLLVNDVNDNPPIFGQPTYNTTLSEASLIGTPVLQVVSTDADSGNNKMVHYQIVQDTYNSTDYFHIDSASGLILTARMLDHESVQHCTLKVRATDNGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGIITLSNHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENAAAGTKVIHVRATDGDPGMYGQISYAIINDFAKDRFLIDGNGQVTTTERLDRENPLEGDISIFLRALDGGGRTTFCTVRVIVVDENDNAPQFLTVEYRASVRADVGRGHLVTQVQAMDPDDGANARITYSLYSEASVSVADLLEIDPDNGWMVTKGHFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETSVPSFTQSQYSFTVSEDTAIGSTVDTLRILPTQKVTFSTVNGERLENNKGNVFIIEQETGTIKLDKRLDHEVSPAFHFKVAATMPLDKVDAVFTVDVDVKVLDLNDNKPVFETSNYETIIMEGMPVGTKLTQVRAMDVDWGANGQVTYSLHSDSQPEKVMEAFSIDSNTGWISTLKDLDHETDPMFTFSVVASDLGEAFSLSSTALVSVRVTDINDNTPVFAHEVYRGNVKESDPPGEVVAVLSTWDRDTSDINRQVSYHITGGNPRGRFALGLVQSEWKVYVKRHLDREEQDIYFLNITATDGLFVTQAMVEVTVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGPNGDIRYSLYGPGNNEFFLDPESGELKTLAPLDRERVPAYSLVARATDGGGRFCQSDLRLTLEDVNDNPPVFSSDHYNACVYENTATKALLTRVQAVDPDVGVNRKVVYSLADSANGFFSVDSSSGIVVLERPLDREQQSSYTLRVQATDQSPGRALSSLATISITVLDVNDNPPVFERRDYLVSVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFRINPKTGGISVSEALDYELCRKFYLMVEAKDGGTPALSAVTTVGINLTDVNDNPPEFSQDVYSAVISEDALVGDSVILLIAEDADSQPNGQIRFSIVNGDRDNEFAVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGMPAMSSTATVNIDISDVNDNSPVFTPANATAVIQENKPVGTSVLQLMVTDKDSFHNGPPFSFSILSGNEEEAFVLDSDGILRSAVVFQHTESPEYVLCVQAKDSGKPQQVSHSYVRVRVIEESIHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDVLTFALKSEQKSLFKVNSHDGKIIALGGLDSGKYVLNVSVSDGRFQVPIDVVVHVEQLVQEMLQNTVTIRFENVSPEDFVGLHMHGFRRTLRNAVLTQKQDSLHIISIQPVAGTSELDMLFAVETHSSEFYKPAYLIQKLSNARRHLENAMRISAILEKNCSGLDCQEQHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTCDGGLCPGANDPCVEKPCPGDMQCVGYEASRRPFLCQCPPGKLGECSGHTSLSFAGNSYIKYRLSENSKEEDFKLALRLRTLQSNGIIMYTRANPCIILKIVDGRLWFQLDCGSGPGILGISGRAVNDGSWHSVFLELNRNFTSLALDDSYVERRRAPLYFQTLGTDSAIYFGALVQADSIRSLTDARVTQVLSGFQGCLDSVVLNNNELPLQNKRSSFAEVVGLTELKLGCVLYPDACERGPCQHGGSCAGLASGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSCDPIGNTFICSCKAGLTGVTCEEDVNECEREECENGGACVNVFGSFVCNCTPGYVGQYCGLRPVVVPNIQAGHAYVGREELIGIAAVLLVIVALIVLFVVFRKKVFRKSYSRNNITLVQDPATAALLRKSNGVPFRSLRAGDGRHAYQEAGPPQVPVRPMAYTPCFQGDSRSNLDKIGDGLGGEPQEMTTFHPESPRILTARRGVVVCSVAPNLPAVSPCRSDCDSIRKNGWDAGTENKGVDDPGEVTCFAGSNKGSNSEVQSLSSFQSDSGDDNAYHWDTSDWMPGARLSDIEEVPTYESQEGAAPPGSARGLESDYYLGGYDVDSEYPPPHDDDFLGQDPLPPPLPEDFADQYDGLPPARPGSLAGTLSPGCRRRPQFHPSQYLPPHPFPHETDVGGPPAAGEFSTFAVSVNPGAEAAAGPADGVALSLHNSRGPSSSDVSASCGFDDSEVAVSDYESVGELSLASLHIPFLETQQQTQV", "length": 4555, "header": "tr|F1MC84-1|F1MC84_BOVIN Isoform 1 of Protocadherin Fat 3 OS=Bos taurus OX=9913 GN=FAT3 PE=4 SV=3 CANONICAL=F1MC84-1" }, "locus": { "chromosome": "29", "start_pos": 2635494, "end_pos": 1996707, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005332.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005332.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005332.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005332.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:536281", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536281", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A2R8QAL3-1", "protein_name": "Protocadherin Fat 3a isoform X1", "gene_name": "fat3a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAVSMALWAGIWAILLQLALLLFFTVPPGHCQGERFRLQFTQPLYHASVYENSAARTYASSQVRMGIPLQHHSWEVRYRITSGDEEGFFKAEEYTLGDFCFLRIRTKGGNAAILNREVQDNYVLTVKASLKGDTLEAWTKVSVQVLDMNDLRPLFSPTTYSVTIAESTPLRTSIAQVTATDADIGSNGEFYYFFKERMELFAVHPTSGVVSLSGKLDVDIQSRYDLEIQAVDRGMKLYGNNGVSSTAKLFVHVERINEHVPTLSIVTLAPVWTEKSPIIAVVTVEDLDEGKNGEIETVSIVAGDLLELFSIERTDVPSQEMVDEEDSMKGSNEFVLRAMEQFDWDSYPFGLNLSLQARDRGTPQKLSAVQIVHLRLSRPPPVEVTFQKDQYEVLLSEVAPPGTIVEAVKLQPEPDDAEYILTPSADSGFFSINTMTGVISTARWLTQLKQEVFELEVLEVDSDLRVKVKVILEDANDNAPSFAQQSYEVFVNESVAVGTTVVVVTASDDDHGENGYITYSMASLTPLPFSVQQFTGAVTTTQELDFESSLESFSFVVRASDWGSPYRRESEVNITVHLENVNDNKPLFEKVACVGVVSRELPVGEVIATISAIDIDELELVKYKILSGNERGYFELNPDSGVMTLRHSLITAAPKNSFSLKITATDGEHFSDPMFVNISVVQGKSPPKSFSCTETRVAQRLAEKLLKKAKASSKPKMDEGFIDLFSVNRQTPQFDKSFPTDITVREDVEVGTSVFQVKALDGDTGFNGQLLHAIADGNTDSCFSIGILNGVISIFLPLDREKTDRYLLNITLYDLGQPQRSTWRLLTVYIADANDNAPQFLQDGGYHARISENTPIGTEVIQVEATDKDQGLNGEIQYSLLTSTSQFGINSSSGIVYVAGQLDRELVPLFILKVEARDRAERAAQRFSITTLKITLEDVNDCPPAFIPSVANARALEDLPVGTVIAWLDTQDPDLGLGGQVRYLLDNDYDGRFEVDKTSGAIRLTKELDYETQQFFNLTVRAKDKGRPVSLLSVSFVELEVVDVNENLYAPYFSSFAMNGSVKESVRIGTSVLQVSARDDDTGRDGEVQYSIRDGSGLGRFTIDEETGVIYTTDLLDRETQDSYWLTVYATDLGVVPQSAALQVYIQVEDVNDNSPLTSEPMYHATILENSPKDQSVIQIQAQDPDATTAEPRLSFRISSGNPQNFFSINPRTGLITTTSRKLDREQQAEHVLEVTVSDGGSSPRHTTVWVVIQVLDVNDNKPTFPEKMYQVRLPERSRKQRGAPIYRVFAYDQDQGANAELSYSIIDGNEDGKFIIDAKTGVVSSPKKQFSAGTYDILTVKAVDNGRPQRWATARLHIEWIRRPPPNPIPLAFDEPLYNFTIMETDRVADIVGVVSAQQQGSASLWFDITGPRSFREMFYILQTACGRNCSTEGGDVDSMFDVEKGVGTIVIAKPLDAEQRSFYNLTLEVTDGTNVANTQVHITVLDNNDNPPVFSQPTYDITITEDTPPDTEVVQVLASDRDERHRLTFSLQSSVDPSSMRLFRIDPNSGVIYTARRLDHESRTQHILTIMVKDQEFPYRRSLARVLIGVEDVNDHAPLFTMVMYDGQVYESAALGSAVLTVTALDKDKGQNAQISYSIDSGNTGNTFRIDPVLGIISLARELDLSSIGHYVLSVKATDNGSPALSSTAVVRIAVTLSNNAGPKFPQNEYQAEISESVAIGTSVVTVNALSLSTLTYDIRHGNGHRTFRINQYSGVITTQKSLDFETVSSYVLIVTASNMAGQASNATITVVVLDQNDNAPVFQQLHYRGSISEGAGLNSVVQSDDGQPLVIRASDADRNHNALLVYQIMEESARRFFAVDAGTGSIRTIAQLDHETTPTFRFHVNVRDSGHPQLSAERPAEVTIEVQDVNDCSPKFSQDSYEAVLLLPTYEGVEALQVFATDPDGNGQSELTYSLTDGSLEHFSIEPSTGLLTVRNSTFSKERFRFNVRVSDGRFSSTALVTVLVHEALDSGLAFTHSAYNANIEENNGNITTVAVVTALGNKLNEPLRYTLLNAGGKFRIKPTSGAIETVGVPLDREEKEEYGLLVQAGREEDRLRVARALVRVQVTDVNDNAPVFVGLPYYAAVQVEAEPGTAIFRVTAVDRDKGLNGEVNYFLQDELGHFEVDRVSGELRLRRAFEADLSSVEYQVLVFARDMGTPPLSSSVTFPVTVVNRAMPVFDRPFYSVKVSEDIPVWTPILGINASSPEGQSVLYTITHGDPGTLFSIGFDTGVISVIAGLDYETSPAHRLIVRATDCLTGARAEVDVEVTVLDVNDNPPVFEQPSYKAVISESAMIGTAALQVLATDSDSEKNAAVRYQIIPDRTNSTDHFHIDSSSGLILTARSLDHETIQRYVFLVKATDNGFPPLSSEVWVTVDVTDTNDNAPVFNQLLYEASINELAPKGHFVTCIQASDADRSDAERLQYGLVSGNERMLFELDAASGVLTLSGQRRMQRMPSAITLNVSVSDGVFTSTAQVHVRVERANLHSPQFTQGMYEADVRENAPPGSKVIAIRAQDADPGPFGDVRYVLLSDAARDLFTIDSSGQITTLERLDREERSEMVLSVAAVDAGGRSGYCSVRVTVIDENDNVPLFGASEYHASVRSEVEPGTLVIQVQAWDLDQDANGQVSYSLYSEASLQVTELLDIDPDSGWVVTKGNFAPLRGSVLSFLVKASDGGAPIRHSLVSVYIHVLSADAHIPSFSQPQFSFTVPEDMPIGSLLGAVHLHTSTSHSSLPVSFAAVIGQTPESNSEGVFLVDKESGMIKLDKALDRELTQIYHFKVVAMLQQGRLDAVSAVDVEVKVQDVNDNKPAFESDTYETSVTEGLSPGTRILQVRALDPDWAANGQVTYSLAPPGLLGGSGGEDIEEHGAYFTIDSSSGWISTLKGLDHEQNPAHSLTVWAFDLGDPASQSSSTTITIAVSDSNDNIPQFLQPRYYGSVRESDAPGEVVAVLNTRDNDSSPGNRQVTYHITGGNRGGVFALGLVQGEWKLYVKRPLDREEQERYLINVTATDGLYVSTASVDVTVMDTNDNSPVCEPALYSVSVSEDVPLNKQILRVKATDADTGSNAQIQFSLFGSGAEDFFIHPHTGELKTAVALDREKVSRYSLVARATDGGGLWCEAEVVVDLLDVNDSPPMFSMPHYTTSVYENTATKALLTRIQAIDPDLGVNRKVVYSLVDSADGFFSIDKSSGIVVLERLLDREIQSSYHIVVRASDQGVPVRLSSLANITITVLDINDNPPVFERRDYLATLPEDVAVGTEVVQVYAASKDIGTNADIYYNIRSGNQQGHFTINVNTGAISVSRALDFESCKDYFLTVEATDGGTPPLSAVTMVNINLTDVNDNAPIFSRDAYSVSISEDANIGDTVVKVMAEDVDSYVNGDILYSIISGDRENQFFIEPITGQIKVNKQLDRETMAGYSLSVRALDSGTPAMSSTVLVNIDISDVNDNPPTFTPANHTAVIQENKPLGTSVLQLSVIDKDASHNGPPFHFHILSGNEGAWFKLDREGLLTSNQVFRRSEGTEYVIHVQASDSGRPPLSSVASVLVRVIEESVHKPAASPLHVHIVTMEDEFPGGVIGQIHATDQDAFDILTYGHTHQQSSLFKVSPRDGRIIALSGLDAGRYTLNATVTDGRFTVSVPVSVHVEQASVEMLHDAVTVRFDRVSPHDFISRHLPSVRRVLSSVMSTSRPDALHVLSVQPVEATGQLDLLVAVESAEGGGFYKAALVTQKLSSARRQLDQVLRVSAVLDKNCSGLDCREAQCEQTITLDSHSLLTYSSTKTSFVSPKFHRNTRCVCSDGSCSAASEVCADMRCPGDMQCVGTDSSRGPYACQCPPGKLGECAGHTSLSFSGNSYIKYRVTDGERSGEMKLALRIRTLQSKGIIMYTRADPCSVLKIEEGKLWFQLDCGNSPRSIGISGRLVNDGNWHHVVLELRGNYSSLSLDDMYVERRLTTAKFRPLEADLSIYFGAQVLPPDARSLTEMKGPRVTNGFQGCLDSVVLNDNELPLQNKRSPYAEVVGLTDLKLGCVLYPDACVAQPCLNGATCISLPSGGFSCSCSALHTGGRCETEISVCMPNPCQNGGVCKPIGNAFICSCKRGYTGATCEEDVNECERELCENGGICINTFGSFYCNCTPGFVGSACSVRPVLVPDMQAGHAYVGKEELIGIAVVLFLILTLILLFIAFRKKVFQKSYSRNNLSLVQDPATAALLHKANGGHYPPLRCAIGEPISLYTEGGITGPPQVPVRPMAYTPCFPGDARGTLEKRDGRGSELTEMSTFHPSESPRILGGTNRRGVVVCSVAPNLPPVSPCRSDCDSLRKSPWEEDGKVDLLEEVTCFSGSNKGSNSEVQSLSSFQSDSCDDNASIVTVIRLVNDAVDTIENEVSVMDQGQNFNRAYHWDTSDWLPSTRLPDIEEVPTYETPEVGVALESDYYLGGFDIDSDYPPPQEEEFMSQDQLPPPLPTEEFDTSPANQPVSRESTLSGDRKPRPHFHPSQYLPPHQLPLGSTGEEFSTFTGREERLSVNASSASSVSSAPCGFEDSETGGSLDSFEDMHPHTQQTEV", "length": 4601 }, "evidence": [ { "id": "F1MC84", "url": "https://omabrowser.org/oma/group/F1MC84/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0XZB0-1", "protein_name": "Protocadherin Fat 3", "gene_name": "FAT3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEMNMGHWSGTRPPPPCLALLLAELLASLFQVAHGATPLGFHFTHSTYNATVYENSAARTYVNSQTRMGITLSDLSWDIKYRIVSGDDEGFFKAEEVVIADFCFLRIRTKGGNSAILNREIQDNYLLVVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSIAQVTATDADIGSNGEFYYYFKSKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTISVVTHIPFPSDKEPTYAVVNIDDLDEGANGEIESVSIVAGDPLEQFFLIKEGKWMNEYKIKERKPIDWDSFPYGYNLTLQAKDKGSPQKFSAVKLVHIASPKKESIPLKFEKEAYDVSVSEFSPPGVVVAVVKLMPEPLGVEYRISPSEGAENFKINPITGLITTARSLKIIEKDLYELEVYTNKGDDLKAQVTIRLEDANDHTPEFQQTSYSSFVNESVPVGFSVLAVSAVDKDRGENGYITYSIASLNSLPFIINQFTGVISTSEELDFESSPESYRFIVRASDWGSPYRHESEVNVTIYIGNVNDNKPLFEKVACQGVISSDFPVGGHITAVSAIDIDELELVKYKIISGNELGIFYLNPDSGVLQLKKSLINSGIKNSNFGLKITATDGENFADAMFVNISVVHGKVSSKTFSCRETRVAQRLAEKLLKKAKANVKLNLEDGFLDYYSVNRQAPHFDKTFPTDVMVSEDLPVGATILRIKAYDADSGFNGKVVYTISDGNADSCFNIDIETGVLKVLMPLDREKTDLYILNITIYDLGNPQKSAWRLLTVTVGDANDNKPIFLQDSYSVNILESTSLGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGVVYVADQLDRETKANYTLKIEARDKAESGHQQFSVVPLKVFLDDVNDCSPAFIPSSYNVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLYTPYFPDFAVIGSVKENSRIGTSVLQVVARDEDSGRDGEIQYSIRDGSGLGRFSIDEETGVIYTADVLDRETTKSYWLTVYATDHGVVPLYATIEVYIEVEDVNDNAPLTSEPIYYPSVMENSPKDVSVIQIQAQDPDSSTNEKLAYRITSGNPQNFFVINPKTGLITTTSRKLDREQQAEHFLEVTVSDGGTSPKQSSVWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPTPSPVPLTFDEPFYNFTVMESDKVTEIVGVVSVQPSNIPLWFDIVGGKHAREMFYILQTACGQNCSTEGGNYDSSFDAEKGVGTIVIAKPLDAEQRSIYNMTVEVTDGTNVATTQVFIKVLDNNDNGPEFSQPSYDVTISEDILPDTEILQIEAIDRDEKHKLSYTIHSSIDAISMRKFRIDPSAGVLYTAERLDHEAQDKHILNVMVRDQEFPYRRNLARVIINVEDSNDHSPYFTSPLYEASVYESAAVGSAVLQVTALDKDKGENAELVYTIEAGNTGNTFKIEPVLGIITLLKEPDLTTMGQFVLSVKVADQGSPPLSATAIVRISVTMADNSHPKFTLKEYQAEVNENVDIGTSVISLSAISQSTLVYEIKDGNVDGLFTINPYSGVITSQKALDYEHASFYQLTVQATNMAGMASNATVNIQIVDENDNPPVFLFSQYSGSISEAAPINSIVRSTNNSPLVIRATDADSNQNALLVYQIVESTAKKYFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGNPQLTAESPVEVTIEVTDVNDNPPVFSQAVFETVLLLPTYVGVEVLKVKATDPDSEIPPELTYSLIEGNMDHFLIDSNTGVLTIKNNSLSKDHYMLIVRVSDGKFYSTAMVTIMVKEAMDSGLHFTQNFYSTSISENTTNITKIAVVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGISFDREEQELYELVVEASRELDHLRVARVVVRVYIEDINDNAPVFVGLPYYAAVQVDAEPGTLIYRVTAIDKDKDENGDVSYLLKEDYGHFEIDRGTGSVTLKEAFNSDLSNIEYLVVILAKDGGNPSLSASVELPITIVNKAMPVFDKPFYTASVNEDVEIHTPILSINATSPEGQGIIYIIVEGDPHNQFNIDFDTGVLSVISPLDYEINSLFKLMVRASDALTGARAEVTVDLVINDVNDNPPVFDQSAYNATLSEASLIGTPVLQVVATDADSDNNKIVQYQIVQDTFNSTDYFHIDSTSGLILTARMLDHELIQQCSLKVRATDNGFPPLSSEVLVSISITDMNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFIMDSKSGVITLSNHRKQRMEPMYSLNVSVSDGLFTSTAQVHIQILGANLYSPVFSQSVYVAEVRENAAPGTKVLHVKATDGDSGVYGQISYSIINDFAKDRFLIDSNGQILTTERLDRENLLESDIGIFLRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVKADVGKGYLVTQVQAVDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGSFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETILPSFSQPQYSFTLAEDTLIGSTIDIVHIVPNQGALYSTVNGELTENNKDGIFIIEQDTGLIKLDKRLDHETNSAFHFKVAATIQLDKVDIVLTVDVEVKVLDVNDNKPMFETASYDAIIMEGMPIGTKLMQVKAVDADSSANGQVTYTLAVESELEKITEAFTIDSNSGWISTLKDLDHEKDPTFTFAVVASDLGETLSLSSTTLVSVAVTDINDNAPVFEHEVYRGSVKESDPPGEVVAVLSTWDEDTSDVNRQVSYHITGGNPKGKFALGLVQNEWKVYVKRPLDREEQDVYYLNITATDGLFVTQAAVEVTVTDVNDNSPVCEQVAYTALFPEDIPSNKVILKISAKDADIGSNGDIRYSLYGPGNNKFFLDPENGELKSLAPLDREKIPVYNLVARATDGGGRFCQSEIHLILEDVNDNPPVFSSDHYTACVYENTATKALLTRVQATDPDVGVNRKVTYSLADSADGYFSVDRSSGIIILEHPLDRELQSSYNISVKASDQSIVLTLSSFATVTITVLDINDNPPVFERRDYLVTVPEDTSPGTEVLSVFATSQDIGTNAEITYLIRSGNEKGKFNINSKTGAISISESLDYESCKDFYLVVEAKDGGTPALSAVTTVNINVTDVNDNAPKFSQVVYSAVISEDAAIGDSVIMLIAEDLDSPSNGQIHFSIVSGDQDNEFSVDPGSGLVKVKKKLDRERISGYSLVIQARDSGTPPLSSSVTVNVDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDKDSFHNGPPFTFTILTGNEEEEFTLDPNGVLRSAVIFKHMVATEYVLCVQAKDSGKPQQVSHTYIQVRVIEESIHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDVYDVLTYTLKSEQKSLFKVNNHDGKIIALGGLDNGKYILNVSVSDGRFQVPIDVVVQVEQLLQEMLQNTVTIRFDNVSPEDFVGLHMHGFRRTLRNAVLSQKQDSLHIISIQPVAGSNQLDMLFAVQMHSGGFYKPAFLIQKLTNARRHLENVIRISAILEKNCSGLDCQEQHCEQSLSIDSHSLMTYSTARISFVCPRFYRNVRCMCNGGLCPGSNDPCLEKPCPGDMQCVGYEANRRPFICQCPPGKLGECSGHTSLSFAGNSYIKYRVSENSKKEEFKLALRLRTLQSNGIIMYTRANPCIILKIVDGKLWFQLDCGTGPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRKAPLYFQTLSTDSSVYFGAQVQVDNVRSLTDKRTTQVLSGFQGCLDSVVLNNNELPLQNKRSSFAEVVGLTELKLGCVLYPDACERHPCQNGGTCTSVPSGGYQCNCLSQFTGRNCESEITACFPNPCRNGGSCDPIGNAFICNCKNGLTGVTCEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYCGLRPVVVPNIQAGHSYVGKEELIGIAVVLFVIFVLIVLFIIFRKKVFRKNYSRNNITLVQDPATAALLNKSNGIQFKNIRNSGDSRNIYQEVGPPQVPVRPMAYTPCFQSDSRNNLDKIVDGLGVEHQEMTTFHPESPRILTARRGVVVCSVAPNLPAVSPCRSDCDSIRKSTWDAGTESKGVDDAEEVTCFAGSNKGSNSEVQSLSSFQSDSGDDNASIVTVIQLVNNVVDTIENEVSVMDQGQNYNRAYHWDTSDWMPSARLSDIEEVPNFEAADGGSAHHGSTRELETDYYLGGYDIDSDYPPPHEEEFLSQDQLPPPLPEDYPDQYETLPPSQPVSMANTLSPDCRRRPHFHPSQYLPPHQFPHETDTTGAQTGNEFSTFAVGPSQNTENVSAGKMPLTLHNSLDASSSDVSASCGFDDSEVAMSDFESVEELKLENVHIPFVETQHQTQV", "length": 4612 }, "evidence": [ { "id": "F1MC84", "url": "https://omabrowser.org/oma/group/F1MC84/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8BNA6-1", "protein_name": "Protocadherin Fat 3", "gene_name": "Fat3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVTMGHCMGTKPPSCIILLLLKLFATVSQGLPGTGPLGFHFTHSTYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIIKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPIIHVVSHTPFSLDKEPTYAVVTVDDLDEGANGEIESLSIVDGDPLEQFFLAKEGKWLNEYKVKERRQVDWESFSYGYNLTIQAKDKGSPQKFSELKTVHIANPRRDNTPVRFEKDVYEVSISEFSPPGVLVAIVKVSPEPLDVEYKLLPGKDSDYFKINPRSGLIVTAQPLNTVKKEVYKLEVSDKEGDAKAQVTIGIEDANDHTPEFQEALYETFVNESVRVGTNVLTVSASDKDKGENGYITYSIASLNLLPFAINQFTGVISTTEELDFESSPETYRFIVRASDWGSPYRHESEVNVTIRVGNVNDNSPLFEKVACQGVISYDFPVGGHITAISAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSGIKNGNFALRITATDGENFADPMAINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPHFDKSFPSDVAVKEDMLVGTNILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKSSWRLLTVNVEDANDNNPVFLQDSYSVSILESSSIGTEIIQVEARDKDLGSNGEVMYSVLTDTHQFIINSSTGIVYIADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKIFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETQDPDLGLGGQVRYSLVNDYNGRFEVDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADSLDRETTASYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGSSPKQSTIWVVVQVLDENDNRPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDKVTEIVGVVSVQPANTPLWFDIVGGNFDSSFDAEKGVGTIVIAKPLDAEQRSVYNMSVEVTDGTNIAVTQVFIKVLDNNDNGPEFSQPHYDVTISEDVLPDTEILQIEATDRDEKHKLSYTIHSSIDAVSMRKFRMDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSVVLQVTALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMAAMGQFVLSVKVTDQGSPPMSATAIVRISISMSDNSHPKFTHKDYQAEVNENVDIGTSVILISAISQSTLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMAGMASNATISVQIVDENDNPPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEAIAHFHFHVHVRDSGNPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETVLLLPTYIGVEVLKVSATDPDSEVPPELTYSLMEGSVDNFLMDPNTGVLTIKNNNLSKDHYMLIVRVSDGKFYSTAMVTVMVKEAMDSGLHFTQSFYSTSISENSTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDVNDNSPVFVGLPYYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVLQDDYGHFEINPNSGNVILREAFNSDLSNIDYGVTILAKDGGNPSLSTFVELPITIVNKAMPVFDKPFYTASINEDITMNTPILSINATSPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVTSVYKLTVRASDALTGARAEVTVDLLVDDINDNPPVFDQPTYNTTLSESSLIGTPVLQLVSTDADSGNNKLVRYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNGFPSLSSEVLVQIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDLDRLEYSILSGNDRASFLMDSKSGVLTLSSHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENAASGTKVIHVRATDGDPGTYGQVSYSIINDFAKDRFLIDSNGQIITTERLDRENPLEGDISIYLRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQALDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDGGIPVRHSLIPVYIHVLPPETFLPSFTQSQYSFTITEDTSIGSTVDTLRILPNQSVRFSMVNGERPENNKEGVFIIEQETGAIKLDKRLDHEVSPAFHFKVAATIPLDKVDIVFTVDVDVKVLDLNDNKPVFETSTYETIIMEGMPVGTKLAQVRAIDMDWGANGQVTYSLHSDSHLEKVIEAFNIDSNTGWISTLKDLDHETDPAFSFFVVASDLGEAFSLSSMALVSVKVTDINDNAPVFAHEVYRGNVKESDPPGEVVAVLSTLDKDTSNINRQVSYHITGGNPRGQFALGMVQSEWKVYVKRPLDREEQDIYFLNITASDGLFVTQAMVEVTVSDVNDNSPVCDQVAYSASLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNNEFFLDPESGELKTLAVLDRERVPVYNLIARATDGGGRFCSSSVLLLLEDVNDNPPVFSSNHYTACVYENTATKALLTRVQAMDPDVGINRKVVYSLEDSASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSPGQSLSSLASVTITVLDINDNPPVFERRDYLVTVPEDTSLGTQVLSVFATSKDIGTNAEITYLIRSGNEQGKFSINPKTGGISVLEALDYETCRRFYLVVEAKDGGTPALSTAATVSIDLTDVNDNPPRFSQDVYSAVISEDALEGDSVILLIAEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIPAMSSTTTVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEDEEFMLDSHGILRSAVVFRHMESPEYLLCIQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDVLTFALKSEQKSLFKVNSHDGKIIALGGLDSGKYVLNVSVSDGRFQVPIDVVVHVEQLVHEMLQNTVTIRFEDVSPEDFVGLHMHGFRRILRNAVLTQKQDSLRIISIQPVVGTNQLDMLFAVEMHSSEFYKPAYLIQKLSNARRHLENVMHIAAILEKNCSGLDCQEQHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTCNGGVCPGSNDPCVEKPCPEDMQCVGYEASRRPFLCQCPPGKLGECSGHTSLSFAGNSYIKYRLSENSKEEDFKLALRLRTLQSNGIIMYTRANPCMILKIVEGKLWFQLDCGSGPGILGISSRAVNDGSWHSVFLELNRNFTSLALDDSYVERRRAPLYFQTLSTDSAIFFGALVQADNVRSLTDTRVTQVLGGFQGCLDSVVLNHYELPLQNKRSSFAEVVGLTELKLGCVLYPDACQRSPCLHGGSCSSLPSGGYQCSCLSQFTGTNCESEITACFPNPCRNGGSCDPIGNTFVCSCKAGLTGVTCEDDVDECEREECENGGSCVNLFGSFFCNCTPGYVGQYCGLRPVVVPNIQAGHSYVGKEELIGIAVVLFVIFTLIVLFIVFRKKVFRKNYSRNNITLVQDPATAALLHKSNGIPFRSLRAGDGRNVYQEVGPPQVPVRPMAYTPCFQSDSRSNLDKGLDVLGGEPQEMSTFHPESPRILTARRGVVVCSVAPNLPAVSPCRSDCDSIRKNGWDTGSENKGTEDTGEVTCFTNSNKGSNSEVQSLSSFQSDSGDDNAYHWDTSDWMPGARLSDIEEMPNYESQDGGAAHQGSTRELESDYYLGGYDIDSEYPPPHEEEFLSRDQLPPPLPEDFPDQYEALPPSQPTSLTSTMSPDCRRRPRFHPSQYLPPHPLPGETDLGGPSSSCDFSTFAVNMNQGTEVMAPTDSVSLSLHNSRGTSSSEMSARCGFDDSEVAMSDYESAGELSLTNLHIPFVETQQQTQV", "length": 4555 }, "evidence": [ { "id": "F1MC84", "url": "https://omabrowser.org/oma/group/F1MC84/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R508-1", "protein_name": "Protocadherin Fat 3", "gene_name": "Fat3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGVTMRHCIDTRPPSCLIFLLLKLCATVSQGLPGTGPLGFHFTHALYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIIKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPIIHVVTHTPFSLDKEPTYAVVTVDDLDEGANGEIESVSIVDGDPLEQFFLAKEGKWMNEYKVKERRQVDWESFSYGYNLTIQAKDKGSPQKFSELKTVHIANPRRDSTPIKFEKDVYDISISEFSPPGVMVAIVKVNPEPLDVEYKLLPGKDAEYFKINPRSGLIVTAQPLNTVKKEVYKLEVSDKEGDAKAQVTIGIEDANDHTPEFQETLYETFVNESVPVGTNVLTVSASDKDKGENGYITYSIASLNLLPFAINQFTGVISTTEELDFESSPETYRFIVRASDWGSPYRHESEVNVTIRVGNVNDNSPLFEKVACQGVISYDFPVGGHITAISAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSGIKNGNFALRITATDGENFADPMAINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNQEDGFLDFYSINRQGPHFDKSFPSDVAVKENMPVGTNILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKSSWRLLTVNVEDANDNSPVFLQDSYSVSILESSSIGTEIIQVEARDKDLGSNGEVTYSVLTDTHQFVINSSTGIVYIADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKIFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETQDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSISFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADILDRETTASYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGSSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTIMESDKVTEIVGVVSVQPANTPLWFDIIGGNFDSSFDAEKGVGTIVIAKPLDAEQRSVYNMSVEVTDGTNVAVTQVFITVLDNNDNGPEFSQPHYDVTISEDVPPDTEILQIEATDRDEKHKLSYTIHSSIDAISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSVVLQVTALDKDKGENAELIYSIEAGNTGNTFKIEPVLGIITISKEPDMTAMGQFVLSVKVTDQGSPPMSATAIVRISISMSDNSHPKFTHKDYQAEVNENVDIGTSVILISAISQSTLIYEVKDGNINGVFTINPYSGVITTRRALDYEHTSSYQLIIQATNMAGMASNATVSVQVVDENDNPPVFLFSQYSGSLSEAAPINSLVRSLDNSPLVIRATDADSNQNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHEVIAHFHFHVHVRDSGNPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETVLLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSVDHFLMDPNTGVLTIKNNNLSKDHYMLIVRVSDGKFYSTAMVTIMVKEAMDSGLHFTQSFYSTSISENSTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDVNDNSPVFVGLPYYAAVQVDAEPGTLIYRVTAIDKDKGANGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIDYGVTILAKDGGTPSLSTFVELPITIVNKAMPVFDKPFYTASINEDISINTPILSINATSPEGQGIIYLIIDGDPFQQFNIDFDTGVLKVISPLDYEVMSVYKLTVRASDALTGARAEVTVDLLVDDVNDNPPVFDQPTYNTTLSESSLIGTPVLQLVSTDADSGNNNLVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVTATDNGFPSLSSEVLVQIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVLTLSSHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENAASGTKVIHVRATDGDPGTYGQVSYSIINDFAKDRFLIDSNGQIITTERLDRENPLEGDISIYLRALDGGGRTTFCTVRVIVVDENDNAPQFMTLEYRASVRADVGRGHLVTQVQALDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLRNTVLSFFVKAVDGGIPVRHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTSIGSTIDTLRILPNQSVRFSTVNGERPENNKENVFIIEQETGAIKLDKRLDHEVSPAFHFKVAATIPLDKVDIVFTVDVDVKVLDLNDNKPVFETSSYETIIMEGMPVGTKLAQVRAIDTDWGANGQVTYSLHSDSHLEKVMEAFNIDSNTGWISTLKDLDHETDPTFSFFVVASDLGEAFSLSSMALVSVKVTDINDNAPVFAHEVYRGNVKESDPPGEVVAVLSTLDKDTSNINRQVSYHITGGNPRGRFALGMVQSEWKVYVKRPLDREEQDIYFLNITASDGLFVTQAMVEVTVSDVNDNSPVCDQVAYSASLPEDIPSNKIILKVSAKDADIGSNGDIRYSLYGSGNSDFFLDPESGELKTLALLDRERVPVYNLIARATDGGGRFCSSTVLLLLEDVNDNPPVFSSNHYTACVYENTATKALLTRVQAVDPDVGINRKVVYSLEDSASGVFSIDSSSGVIVLEQPLDREQQSSYNISVRATDQSPGQSLSSLTSVTITVLDINDNPPVFERRDYLVTVPEDTSLGTQVLSVFATSKDIGTNAEITYLIRSGNEQGKFRINPKTGGISVLEALDYEMCKRFYLVVEAKDGGTPALSTAATVSIDLTDVNDNPPRFSQDVYSAVISEDALEGDSVILLIAEDVDSKPNGQIRFSIVGGDRDNEFAVDPILGLVKVKKKLDRERVSGYSLLIQAVDSGIPAMSSTTTVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEDEEFMLDSHGILRSAVVFRHMESPEYLLCIQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDVLTFALKSEQKSLFKVNSHDGKIIALGGLDSGKYVLNVSVSDGRFQVPIDVVVHVEQLVHEMLQNTVTIRFENVSPEDFVGLHMHGFRRILRNAVLTQKQDSLRIISIQPVVGTNQLDMLFAVEMHSSEFYKPAYLIQKLSNARRHLENVMHIAAILEKNCSGLDCQEQHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTCNGGVCPGSNDPCVEKPCPEDMQCVGYEASRRPFLCQCPPGKLGECSGHTSLSFAGNSYIKYRLSENSREEDFKLALRLRTLQSNGIIMYTRANPCMILKIVEGKLWFQLDCGSGPGILGISSRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTDSAIFFGALVQADNIRSLTDTRVTQVLGGFQGCLDSVVLNHNELPLQNKRSSFAEVVGLTELKLGCVLYPDACQRSPCLHGGSCSGLPSGGYQCSCLSQFTGTNCESEITACFPNPCRNGGSCDPIGNTFICSCKAGLTGVTCEDDVDECEREECENGGSCVNLFGSFFCNCTPGYVGQYCGLRPVVVPNIQAGHSYVGKEELIGIAVVLFVIFTLIVLFIVFRKKVFRKNYSRNNITLVQDPATAALLHKSNGIPFRSLRAGDGRNVYQEVGPPQVPVRPMAYTPCFQSDSRSNLDKGLDALGGEPQELSTFHPESPRILTARRGVVVCSVAPNLPAVSPCRSDCDSIRKNGWDTGSENKGAEDTGEVTCFANSNKGSNSEVQSLNSFQSDSGDDNAYHWDTSDWMPGARLSDIEEMPNYESQDGGAVHQGSTRELESDYYLGGYDIDSEYPPPHEEEFLSQDQLPPPLPEDFPEQYEALPPSQPTSLTGTMSPDCRRRPRFHPSQYLPPHPLPGETDLGGPPSSCDFSTFAVSMNQGTEVMAPTDSVSLSLHNSRGTSSSDMSARCGFDDSEVAMSDYESAGELSLTNLHIPFVETQHQTQV", "length": 4555 }, "evidence": [ { "id": "F1MC84", "url": "https://omabrowser.org/oma/group/F1MC84/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8TDW7-3", "protein_name": "Protocadherin Fat 3", "gene_name": "FAT3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDIIMGHCVGTRPPACCLILLLFKLLATVSQGLPGTGPLGFHFTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDVLTFALKSEQKSLFKVNSHDGKIIALGGLDSGKYVLNVSVSDGRFQVPIDVVVHVEQLVHEMLQNTVTIRFENVSPEDFVGLHMHGFRRTLRNAVLTQKQDSLRIISIQPVAGTNQLDMLFAVEMHSSEFYKPAYLIQKLSNARRHLENIMRISAILEKNCSGLDCQEQHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTCNGGLCPGSNDPCVEKPCPGDMQCVSYEASRRPFLCQCPPGKLGECSGHTSLSFAGNSYIKYRLSENSKEEDFKLALRLRTLQSNGIIMYTRANPCIILKIVDGKLWFQLDCGSGPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQTLSTESSIYFGALVQADNIRSLTDTRVTQVLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTELKLGCVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSCDPIGNTFICNCKAGLTGVTCEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYCGLRPVVVPNIQAGHSYVGKEELIGIAVVLFVIFILVVLFIVFRKKVFRKNYSRNNITLVQDPATAALLNKSNGIPFRNLRGSGDGRNVYQEVGPPQVPVRPMAYTPCFQSDSRSNLDKIVDGLGGEHQEMTTFHPESPRILTARRGVVVCSVAPNLPAVSPCRSDCDSIRKNGWDAGTENKGVDDPGEVTCFAGSNKGSNSEVQSLSSFQSDSGDDNAYHWDTSDWMPGARLSDIEEVPNYENQDGGSAHQGSTRELESDYYLGGYDIDSEYPPPHEEEFLSQDQLPPPLPEDFPDQYEALPPSQPVSLASTLSPDCRRRPQFHPSQYLPPHPFPNETDLVGPPASCEFSTFAVSMNQGTEPTGPADSVSLSLHNSRGTSSSDVSANCGFDDSEVAMSDYESVGELSLASLHIPFVETQHQTQV", "length": 4557 }, "evidence": [ { "id": "F1MC84", "url": "https://omabrowser.org/oma/group/F1MC84/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VW71-1", "protein_name": "Fat-like cadherin-related tumor suppressor homolog", "gene_name": "kug", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFTMKIKKYVTPVKRKAFTILQWISLLCSLWLIPTVQSKADEKHTATLEYRLENQLQDLYRFSHSVYNVTIPENSLGKTYAKGVLHERLAGLRVGLNAEVKYRIISGDKEKLFKAEEKLVGDFAFLAIRTRTNNVVLNREKTEEYVIRVKAHVHLHDRNVSSYETEANIHIKVLDRNDLSPLFYPTQYTVVIPEDTPKYQSILKVTADDADLGINGEIYYSLLMDSEYFAIHPTTGEITLLQQLQYAENSHFELTVVAYDRGSWVNHQNHQASKTKVSISVKQVNFYAPEIFTKTFSSVTPTSNPLIYGIVRVNDKDTGINGNIGRLEIVDGNPDGTFLLKAAETKDEYYIELNQFAHLNQQHFIYNLTLLAEDLGTPRRFAYKSVPIQIKPESKNIPIFTQEIYEVSIPETAPINMPVIRLKVSDPDLGKNALVYLEIVGGNEGDEFRINPDSGMLYTAKQLDAEKKSSYTLTVSAIDQANVGSRKQSSAKVKISVQDMNDNDPIFENVNKVISINENNLAGSFVVKLTAKDRDSGENSYISYSIANLNAVPFEIDHFSGIVKTTSLLDFETMKRNYELIIRASDWGLPYRRQTEIKLSIVVKDINDNRPQFERVNCYGKVTKSAPMGTEVFVTSAIDFDAGDIISYRLSDGNEDGCFNLDPTSGSLSISCDLKKTTLTNRILKVSATDGTHFSDDLIINVHLMPEDLGGDSSILHGFGSFECRETGVARRLAETLSLAEKNNVKSASPSVFSDLSLTPSRYGQNVHRPEFVNFPQELSINESVQLGETVAWIEAKDRDLGYNGKLVFAISDGDYDSVFRIDPDRGELQIIGYLDRERQNEYVLNITVYDLGNPTKSTSKMLPITILDVNDNRPVIQKTLATFRLTESARIGTVVHCLHATDADSGINAQVTYALSVECSDFTVNATTGCLRLNKPLDREKQDNYALHITAKDGGSPVLSSEALVYVLVDDVNDNAPVFGVQEYIFKVREDLPRGTVLAVIEAVDEDIGPNAEIQFSLKEETQDEELFRIDKHTGAIRTQGYLDYENKQVHNLIVSAIDGGDPSLTSDMSIVIMIIDVNENRFAPEFDDFVYEGKVKENKPKGTFVMNVTARDMDTVDLNSKITYSITGGDGLGIFAVNDQGSITSLSQLDAETKNFYWLTLCAQDCAIVPLSNCVEVYIQVENENDNIPLTDKPVYYVNVTEASVENVEIITLKAFDPDIDPTQTITYNIVSGNLVGYFEIDSKTGVIKTTERKLDRENQAEHILEVAISDNGSPVLSSTSRIVVSVLDINDNSPEFDQRVYKVQVPSSATVNQSIFQVHAIDSDSGENGRITYSIKSGKGKNKFRIDSQRGHIHIAKPLDSDNEFEIHIKAEDNGIPKKSQTARVNIVVVPVNPNSQNAPLIVRKTSENVVDLTENDKPGFLVTQILAVDDDNDQLWYNISNGNDDNTFYIGQDNGNILLSKYLDYETQQSYNLTISVTDGTFTAFTNLLVQVIDINDNPPQFAKDVYHVNISENIEEESVIMQLHATDRDEDKKLFYHLHATQDPSSLALFRIDSISGNVIVTQRLDFEKTAQHILIVFVKDQGAPGKRNYAKIIVNVHDHNDHHPEFTAKIIQSKVPESAAIGSKLAEVRAIDRDSGHNAEIQYSIITGNVGSVFEIDPTFGIITLAGNLNINKIQEYMLQVKAVDLGNPPLSSQIPVHIIVTMSENDPPKFPTNNIAIEIFENLPIGTFVTQVTARSSSSIFFNIISGNINESFRINPSTGVIVINGNIDYESIKVFNLTVKGTNMAAESSCQNIIIHILDANDNIPYFVQNEYVGALPESAAIGSYVLKVHDSSKDHLTLQVKDADVGVNGMVEYHIVDDLAKNFFKIDSTTGAIELLRQLDYETNAGYTFDVTVSDMGKPKLHSTTTAHVTIRVINVNDCPPVFNERELNVTLFLPTFENVFVRQVSAKDADNDTLRFDIVDGNTNECFQIEKYTGIITTRNFEILNNENDRDYALHVRASDGIFSAILIVKIKVLSAIDSNFAFQRESYRFSAFENNTKVATIGLVNVIGNTLDENVEYRILNPTQLFDIGISSGALKTTGVIFDREVKDLYRLFVEAKSMLYDGMNSNVRRAVTSIDISVLDVNDNCPLFVNMPYYATVSIDDPKGTIIMQVKAIDLDSAENGEVRYELKKGNGELFKLDRKSGELSIKQHVEGHNRNYELTVAAYDGAITPCSSEAPLQVKVIDRSMPVFEKQFYTVSVKEDVEMYSALSVSIEAESPLGRSLIYTISSESQSFEIDYNTGSIFVVNELDYEKISSHDVSIRATDSLSGVYAEVVLSVSIMDVNDCYPEIESDIYNLTIPENASFGTQILKINATDNDSGANAKLSYYIESINGQNNSELFYIDVTDGNLYLKTPLDYEQIKYHHIVVNVKDHGSPSLSSRSNVFITVKDLNDNAPCFVEPSYFTKVSVAAVRGQFVALPKAYDKDISDTDSLEYKIVYGNELQTYSIDKLTGVISLQNMLNFTDKSSTVLNISVSDGVHTAYARLKISLLPENVYSPLFDQSTYEAQVPENLLHGHNIITVKASDGDFGTYANLYYEIVSEEMKKIFLIDQTTGVITSKVTFDREKKDEYVVLLKVSDGGGKFGFASLKVIVVDVNDNVPYFLLKEYKMVVSTTVEANQTILTVKAKDDDIVDNGSVHFQIVQKSNDKAVKDVIEINEKTGDIVFKSKAESYGVNSYQFFVRASDRGEPQFHSEVPVSIEIIETDANIPTFEKSSVLLKIIESTPPGTVLTKLHMIGNYTFKFSIAADQDHFMISDSGELILQQTLDREQQESHNLIVVAETSTVPVFFAYADVLIDVRDENDNYPKFDNTFYSASVAENSEKVISLVKVSATDADTGPNGDIRYYLESDTENIQNIFDIDIYSGWITLLTSLDREVQSEYNFKVIAADNGHPKHDAKVPVTIKIVDYNDNAPVFKLPIEGLSVFENALPGTVLINLLLIDPDIEKQEMDFFIVSGDKQAQFQIGKSGELFIAKPLDREQLMFYNLSIIATDGKFTAKANVEIDVKDINDNTPYCLKPRYHISTNESISIGTTLVEVKAIDFDFQSKLRFYLSGKGADDFSIGKESGILKVASALDRETTPKYKLVAHVQDGKDFTQECFSEIIITVNDINDNMPIFSMAQYRVSVPEDAQLNTLITKVHAMDKDFGVNRQIKYSLMGENHDYFKISKSTGIIRLHKSLDRETISLFNLTVKAEDCGVPKLHSIATVAVNILDINDNPPEFSMRQYSCKILENATHGTEVCKVYATSIDIGVNADIHYFIMSGNEQGKFKMDSTTGDLVLNATLDYEMSKFYFLTIQAIDGGTPPLSNNAYVNISILDINDNSPTFLQNLYRINVNEDIFVGSKILDVKATDEDSDVNGLVTYNIERGDNIGQFSIDPKNGTISVSRPLDRETISHYTLEIQACDQGDPQRCNSVPININILDTNDNAPIFSSSNYSVVLQENRLLGYVFLTFKISDADETPNTTPYTFDIRSGNEGGLFRLEQDGSLRTASRFNHNLQDEFVIQVRVFDNGTPPLYSDAWVVVKIIEESQYPPIVTPLEVTINSFEDDFSGAFIGKVHASDQDKYDELNFSLVSGPDDMYQSSKLFNISNNTGKIYAISNLDIGLYKLNVSVSDGKFHVFSIVKINVELVTNDMLKESVVIRFRRISASEFLLSHRKTFMRSIRNIMRCRQKDVILITLQSDYQKASQHAVGNRRARSIDSDLNVVFAVRKQQIIPDSDEFFTSDEIRQTLIDKKNEIENETNLVVEDVLPSTCQSNKNDCVHGECKQILQILKNNVTTTFTDVISFAAPSYIPVNTCVCRPGFDGKHCKETVNACSTDPCSPQRICMPSGSALGYQCVCPKGFSGTYCERKSSKCSNESCDMGLFTAVSFGGKSYAHYKINKVKAKFTLENGFSYSLQIRTVQQTGTLLYASGKVDYNILEIINGAVQYRFDLGSGEGVISVSSINISDGEWHQISLERSLNSAKVMVDNKHVSHGSAPGVNGILNIQSNDIFVGAEVRPHPSIIGYEDIQRGFIGCMANIKIAKESLPLYISGGSTIAALKRFTNVEFKCDPSNVLVRLGICGSQPCANSGICKELDTDVFECACQPRYSGKHCEIDLDPCSSGPCLFGGRCDYHGPNNYSCTCPIHLSGKRCEYGKFCTPNPCKNGGICEEGDGISHCMCRGYTGPTCEIDVDECENQPCGNGATCINEPGSFRCICPSYLTGASCGDPLYSNSISTKLKNFSIEHISGIISGVAVVLVIISCVLCCVVLKRSSSSKRRNRLEKDKNKSSYKEANLNSLVDKDNYCKPNVKLSNLEVNQRPISYTAVPNDNLVLSNRNFVNNLDILRSYGSAGDELENVPFEYQKVNRNKQHVNINSCHSTDADNAYKQEWCEQMHLRTFSENKLNNELKRDFGPSVSRFSTGKLIQVEMPNVCHSSSANFVDYSALANGQYHWDCSDWVRKSHNPLPDITEVPGAEIADSSSLHSNDSNESKSKKAFFVHREDGDVDPTRDIAALNEDIGSEYLDSEAESCLEPFMLPRSSNQPLSRLSSFNNIENEDYKSNTVPLPSKVSHSCKVYLRHPDSYLPTMHFPSETDGESSMTEGPISRMEIKTRRTISENSEEAYLFPCTVGEIGSNSNISVRLCEIEDSELEEFLPQQQTNN", "length": 4699 }, "evidence": [ { "id": "F1MC84", "url": "https://omabrowser.org/oma/group/F1MC84/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MC84", "url": "https://www.uniprot.org/uniprotkb/F1MC84" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "F1MC84", "url": "https://www.uniprot.org/uniprotkb/F1MC84" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "F1MC84", "url": "https://www.uniprot.org/uniprotkb/F1MC84" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "F1MC84", "url": "https://www.uniprot.org/uniprotkb/F1MC84" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "dendrite development", "id": "GO:0016358", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016358", "evidence": [ { "database": "UniProtKB", "id": "F1MC84", "url": "https://www.uniprot.org/uniprotkb/F1MC84" } ], "pmid": "" }, { "name": "neuron migration", "id": "GO:0001764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "evidence": [ { "database": "UniProtKB", "id": "F1MC84", "url": "https://www.uniprot.org/uniprotkb/F1MC84" } ], "pmid": "" }, { "name": "animal organ morphogenesis", "id": "GO:0009887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009887", "evidence": [ { "database": "UniProtKB", "id": "F1MC84", "url": "https://www.uniprot.org/uniprotkb/F1MC84" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "F1MC84", "url": "https://www.uniprot.org/uniprotkb/F1MC84" } ], "pmid": "" }, { "name": "anatomical structure formation involved in morphogenesis", "id": "GO:0048646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048646", "evidence": [ { "database": "UniProtKB", "id": "F1MC84", "url": "https://www.uniprot.org/uniprotkb/F1MC84" } ], "pmid": "" }, { "name": "cell morphogenesis involved in neuron differentiation", "id": "GO:0048667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048667", "evidence": [ { "database": "UniProtKB", "id": "F1MC84", "url": "https://www.uniprot.org/uniprotkb/F1MC84" } ], "pmid": "" }, { "name": "regulation of plasma membrane bounded cell projection organization", "id": "GO:0120035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120035", "evidence": [ { "database": "UniProtKB", "id": "F1MC84", "url": "https://www.uniprot.org/uniprotkb/F1MC84" } ], "pmid": "" }, { "name": "cell-cell adhesion mediated by cadherin", "id": "GO:0044331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044331", "evidence": [ { "database": "UniProtKB", "id": "F1MC84", "url": "https://www.uniprot.org/uniprotkb/F1MC84" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MC84", "url": "https://www.uniprot.org/uniprotkb/F1MC84" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1006, "end_pos": 1008, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1367, "end_pos": 1369, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1429, "end_pos": 1431, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1751, "end_pos": 1753, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1944, "end_pos": 1946, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1993, "end_pos": 1995, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1996, "end_pos": 1998, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2208, "end_pos": 2210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2292, "end_pos": 2294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2331, "end_pos": 2333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2467, "end_pos": 2469, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3000, "end_pos": 3002, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3329, "end_pos": 3331, "annotation": "n_glycosylation_sequon" }, { "start_pos": 341, "end_pos": 343, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3449, "end_pos": 3451, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3618, "end_pos": 3620, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3654, "end_pos": 3656, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3741, "end_pos": 3743, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3926, "end_pos": 3928, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4122, "end_pos": 4124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4187, "end_pos": 4189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 481, "end_pos": 483, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 562, "end_pos": 564, "annotation": "n_glycosylation_sequon" }, { "start_pos": 667, "end_pos": 669, "annotation": "n_glycosylation_sequon" }, { "start_pos": 799, "end_pos": 801, "annotation": "n_glycosylation_sequon" }, { "start_pos": 879, "end_pos": 881, "annotation": "n_glycosylation_sequon" }, { "start_pos": 898, "end_pos": 900, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], 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"id": "ENSBTAP00000100843.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100843.1" } ] } }, { "isoform_ac": "A0AAA9TYA7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYA7/entry", "sequence": { "sequence": "MCGAEAAAGEAAPAPGPSSPQVPGGGCCPSPRDPGPRALSPLFPRLRWDRAAAQPPLLPALRAPRSMSESDMEKAIKESSILEEYNINWTQKLGAGISGPVRVCVKKSTQERFALKILFDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQELKVSLKPLHSVNNPILRKRKLLGTKAKDGVYIHDRENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVVQEAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ", "length": 506, "header": "tr|A0AAA9TYA7-1|F1MH23_BOVIN Computationally mapped isoform of MAP kinase-activated protein kinase 5 OS=Bos taurus OX=9913 GN=MAPKAPK5 PE=3 SV=1 CANONICAL=F1MH23-1" }, "locus": { "chromosome": "17", "start_pos": 62288044, "end_pos": 62257935, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133811.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133811.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101656.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101656.1" } ] } }, { "isoform_ac": "F1MH23-1", "url": "https://www.uniprot.org/uniprotkb/F1MH23/entry", "sequence": { "sequence": "MSESDMEKAIKESSILEEYNINWTQKLGAGISGPVRVCVKKSTQERFALKILFDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALQHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQELKVSLKPLHSVNNPILRKRKLLGTKAKDGVYIHDRENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVVQEAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ", "length": 472, "header": "tr|F1MH23-1|F1MH23_BOVIN Isoform 1 of MAP kinase-activated protein kinase 5 OS=Bos taurus OX=9913 GN=MAPKAPK5 PE=3 SV=2 CANONICAL=F1MH23-1" }, "locus": { "chromosome": "17", "start_pos": 62287559, "end_pos": 62257935, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012303.5", "url": "https://www.ensembl.org/id/ENSBTAT00000012303.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012303.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012303.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-2559580", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559580", "resource": "Reactome", "description": "Oxidative Stress Induced Senescence" }, { "id": "R-BTA-5687128", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5687128", "resource": "Reactome", "description": "MAPK6/MAPK4 signaling" }, { "id": "R-BTA-6804756", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804756", "resource": "Reactome", "description": "Regulation of TP53 Activity through Phosphorylation" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LN87-1", "protein_name": "MAP kinase-activated protein kinase 5", "gene_name": "Mapkapk5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEDSNMEKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCATHSNIVEIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQATLALQHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKVDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGLIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRKKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGSKPKDGVYIHDHENGVEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQEAWKYNRECKLLRDALQSFSWNGRGFTDKVDRLKLAEVVKQVIEEQTLPHEPQSSEIALLVCRAGTWKRL", "length": 490 }, "evidence": [ { "id": "F1MH23", "url": "https://omabrowser.org/oma/group/F1MH23/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O54992-1", "protein_name": "MAP kinase-activated protein kinase 5", "gene_name": "Mapkapk5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEDSDMEKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALQHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKVDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRKKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDGIYIHDHENGTEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQEAWKYNRECKLLRDALQSFSWNGRGFTDKVDRLKLAEVVKQVIEEQTLPHEPQ", "length": 473 }, "evidence": [ { "id": "F1MH23", "url": "https://omabrowser.org/oma/group/F1MH23/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IW41-1", "protein_name": "MAP kinase-activated protein kinase 5", "gene_name": "MAPKAPK5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"name": "regulation of translation", "id": "GO:0006417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006417", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" }, { "name": "Ras protein signal transduction", "id": "GO:0007265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" }, { "name": "negative regulation of TOR signaling", "id": "GO:0032007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032007", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "septin cytoskeleton", "id": "GO:0032156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032156", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" }, { "name": "mitogen-activated protein kinase binding", "id": "GO:0051019", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051019", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" }, { "name": "p53 binding", "id": "GO:0002039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" }, { "name": "calcium-dependent protein serine/threonine kinase activity", "id": "GO:0009931", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009931", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" }, { "name": "calcium/calmodulin-dependent protein kinase activity", "id": "GO:0004683", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004683", "evidence": [ { "database": "UniProtKB", "id": "F1MH23", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" }, { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" }, { "start_pos": 304, "end_pos": 306, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", 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"P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "R-BTA-3238999", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-ALL-29358" ], "output_participant_list": [], "enzyme_list": [ "Q5E9X2-1", "G3X793-1", "A0A3Q1LTT9-1", "F1MH23-1" ], "evidence": [ { "id": "R-BTA-3238999", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3238999" } ] }, { "id": "R-BTA-3239014", "name": "MAPKAPK5 phosphorylates TP53", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3X793-1", "A0A3Q1LTT9-1", "F1MH23-1" ], "evidence": [ { "id": "R-BTA-3239014", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3239014" } ] }, { "id": "R-BTA-3239019", "name": "Active p38 MAPK phosphorylates MAPKAPK5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G3X793-1", "A0A3Q1LTT9-1", "F1MH23-1" ], "evidence": [ { "id": "R-BTA-3239019", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3239019" } ] }, { "id": "R-BTA-5687088", "name": "PKA phosphorylates MAPKAPK5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-2562517" ], "output_participant_list": [ "R-BTA-5687026" ], "enzyme_list": [ "P00517-1", "F1MH23-1" ], "evidence": [ { "id": "R-BTA-5687088", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5687088" } ] }, { "id": "R-BTA-5687091", "name": "p-S MAPK6,4 binds MAPKAPK5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MVV5-1", "G5E577-1", "F1MH23-1" ], "evidence": [ { "id": "R-BTA-5687091", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5687091" } ] }, { "id": "R-BTA-5687094", "name": "p-S MAPK6,4 phosphorylate MAPKAPK5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MVV5-1", "G5E577-1", "F1MH23-1" ], "evidence": [ { "id": "R-BTA-5687094", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5687094" } ] }, { "id": "R-BTA-5687101", "name": "p-T182 MAPKAPK5 phosphorylates FOXO3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-BTA-5687032" ], "output_participant_list": [ "R-BTA-5687014" ], "enzyme_list": [ "F1MH23-1" ], "evidence": [ { "id": "R-BTA-5687101", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5687101" } ] }, { "id": "R-BTA-5687120", "name": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MVV5-1", "G5E577-1", "F1MH23-1" ], "evidence": [ { "id": "R-BTA-5687120", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5687120" } ] }, { "id": "R-BTA-5687121", "name": "p-S MAPKAPK5 phosphorylates HSPB1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-BTA-450563" ], "output_participant_list": [ "R-BTA-5687009" ], "enzyme_list": [ "F1MH23-1" ], "evidence": [ { "id": "R-BTA-5687121", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5687121" } ] }, { "id": "R-BTA-5687123", "name": "p-S115 MAPKAPK5 translocates to the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-BTA-5687028" ], "enzyme_list": [ "F1MH23-1" ], "evidence": [ { "id": "R-BTA-5687123", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5687123" } ] }, { "id": "R-BTA-5690245", "name": "p-T182 MAPKAPK5 binds DNAJB1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MH23-1" ], "evidence": [ { "id": "R-BTA-5690245", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5690245" } ] }, { "id": "R-BTA-5690250", "name": "p-T182-MAPKAPK5 phoshphorylates DNAJB1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MH23-1" ], "evidence": [ { "id": "R-BTA-5690250", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5690250" } ] }, { "id": "R-BTA-5692779", "name": "p-T182 MAPKAPK5 phosphorylates FOXO1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-199300" ], "output_participant_list": [ "R-BTA-5692651" ], "enzyme_list": [ "F1MH23-1" ], "evidence": [ { "id": "R-BTA-5692779", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5692779" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29358", "participant_name": "ATP [nucleoplasm]", "crossref": [ { "id": "30616", "database": "ChEBI", "url": "" }, { "id": "ZINC000004261765", "database": "ZINC", "url": "" }, { "id": "C00002", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-BTA-199300", "participant_name": "FOXO1 [nucleoplasm]", "crossref": [ { "id": "A0A452DJI7", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000044105", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000053389", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000061127", "database": "ENSEMBL", "url": "" }, { "id": "XP_024855821.1", "database": "RefSeq", "url": "" }, { "id": "29098", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-2562517", "participant_name": "MAPKAPK5 [nucleoplasm]", "crossref": [ { "id": "F1MH23", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000009346", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000012303", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000012303", "database": "ENSEMBL", "url": "" }, { "id": "31230", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-450563", "participant_name": "HSPB1 [cytosol]", "crossref": [ { "id": "Q3T149", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000011969", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000041898", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000044397", "database": "ENSEMBL", "url": "" }, { "id": "NP_001020740.2", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-5687009", "participant_name": "phospho-HSPB1 [cytosol]", "crossref": [ { "id": "ENSBTAP00000041898", "database": "ENSEMBL", "url": "" }, { "id": "NP_001020740.2", "database": "RefSeq", "url": "" }, { "id": "Q3T149", "database": "UniProt", "url": "" }, { "id": "ENSBTAT00000044397", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000011969", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-5687014", "participant_name": "phospho-FOXO3 [cytosol]", "crossref": [ { "id": "ENSBTAT00000014920", "database": "ENSEMBL", "url": "" }, { "id": "XP_005210861.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAG00000011234", "database": "ENSEMBL", "url": "" }, { "id": "29099", "database": "VGNC", "url": "" }, { "id": "ENSBTAP00000014920", "database": "ENSEMBL", "url": "" }, { "id": "F1N4K5", "database": "UniProt", "url": "" }, { "id": "NP_001193012.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-5687026", "participant_name": "phospho-MAPKAPK5 [nucleoplasm]", "crossref": [ { "id": "ENSBTAP00000012303", "database": "ENSEMBL", "url": "" }, { "id": "31230", "database": "VGNC", "url": "" }, { "id": "F1MH23", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000009346", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000012303", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-5687028", "participant_name": "phospho-MAPKAPK5 [cytosol]", "crossref": [ { "id": "F1MH23", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000012303", "database": "ENSEMBL", "url": "" }, { "id": "31230", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000012303", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000009346", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-5687032", "participant_name": "FOXO3 [cytosol]", "crossref": [ { "id": "F1N4K5", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000011234", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000014920", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000014920", "database": "ENSEMBL", "url": "" }, { "id": "NP_001193012.1", "database": "RefSeq", "url": "" }, { "id": "XP_005210861.1", "database": "RefSeq", "url": "" }, { "id": "29099", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-5692651", "participant_name": "phospho-FOXO1 [nucleoplasm]", "crossref": [ { "id": "ENSBTAP00000053389", "database": "ENSEMBL", "url": "" }, { "id": "XP_024855821.1", "database": "RefSeq", "url": "" }, { "id": "A0A452DJI7", "database": "UniProt", "url": "" }, { "id": "ENSBTAT00000061127", "database": "ENSEMBL", "url": "" }, { "id": "29098", "database": "VGNC", "url": "" }, { "id": "ENSBTAG00000044105", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": 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"ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": 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"ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": 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"uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": 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"ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G3X793", "gene_name": "MAPK11", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3X793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X793" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G3X793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X793" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": 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"uniprot_id": "F1MCG5_BOVIN", "mass": { "chemical_mass": 79380.0, "monoisotopic_mass": 79380.0 }, "refseq": {}, "gene_names": [ { "name": "TAP2", "type": "recommended", "evidence": [ { "id": "F1MCG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ] } ], "protein_names": [ { "name": "Antigen peptide transporter 2", "type": "recommended", "evidence": [ { "id": "F1MCG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCG5/entry#names_and_taxonomy" } ] }, { "name": "7.4.2.14", "type": "synonym", "evidence": [ { "id": "F1MCG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCG5/entry#names_and_taxonomy" } ] }, { "name": "ATP-binding cassette sub-family B member 3", "type": "synonym", "evidence": [ { "id": "F1MCG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCG5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TAP2", "url": "https://www.uniprot.org/uniprotkb/F1MCG5", "locus": { "chromosome": "23", "start_pos": 7138826, "end_pos": 7146359, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003038", "url": "https://www.ensembl.org/id/ENSBTAG00000003038" } ] } } ], "crossref": [ { "id": "F1MCG5", "url": "https://alphafold.ebi.ac.uk/entry/F1MCG5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003038", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003038", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18590", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18590", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005293", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005293", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013305", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013305", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ERQRMTI", "url": "https://omabrowser.org/oma/group/ERQRMTI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BJS0", "url": "https://www.orthodb.org/?gene=E1BJS0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MCG5", "url": "https://www.orthodb.org/?gene=F1MCG5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43394:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43394:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00664", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00664", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-983170", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983170", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "65972", "url": "https://www.rhea-db.org/rhea/65972", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BJS0", "url": "https://www.uniprot.org/uniprotkb/E1BJS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BJS0-1", "url": "https://www.uniprot.org/uniprotkb/E1BJS0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCG5-1", "url": "https://www.uniprot.org/uniprotkb/F1MCG5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSPDLRPWASLLLADLALLWLLQGPLGALLPLGFPGLWLEGALRLGGLWGLLRLGGLLEGVGALLPILCLVNPLFLSLRALVLGALSAPLVRVAAATWAWLLLGYGAVGLSRALWAVLSPSGAKAEGQGQENRVLMWRLLKLSWPDLPFLVAAFSFLSLAVLGETVIPYYFGRVIDILGGDFDPDAFASAIFFVCLFSVGSSLCAGCRGSIFIFTMSRINLRIREMLFSSLLHQDLPFFQETKTGELNSRLSSDTKLMSNWLPYNTNVLSRSLVKVLGLYGFMLNLSPRLTFLSLFEVPLMIAAEKVYNARRQAVLWEIQDATAKAGQVVRESVGGLQTVRSFGAEEQEVCRYKEALERCRRLWWRRDLERALYLLLRRMLHLAMKVLLLNCALQQILAGDLTRGGLLSFLLYQEDMGNYMHTLVYMFGDMLSNVGAAEKVFRYLDRKPDLPPPGTLAPPTLQGRVNFQNVSFAYPSRPDQPALQGLTFTLSPGQMTALVGPNGSGKSTVAALLQNLYQPTEGQVLLDGKPVSEYEHHYLHRQVVLVGQEPVLFSGSVRDNITYGLKGCSDEKVLAAARAARAEEFIRELELGLDTEVGEKGSQLAVGQKQRLAIARALVRDPRVLILDEATSALDVECEQALQDWRAQGTRTVLVIAHRLQTVQSADQVLVLRQGRLQGLEQLMDGQDLYSWLVQQNRSVETPDTAGPAQGHLSDPE", "length": 719, "header": "tr|F1MCG5-1|F1MCG5_BOVIN Isoform 1 of Antigen peptide transporter 2 OS=Bos taurus OX=9913 GN=TAP2 PE=3 SV=2 CANONICAL=F1MCG5-1" }, "isoforms": [ { "isoform_ac": "E1BJS0-1", "url": "https://www.uniprot.org/uniprotkb/E1BJS0/entry", "sequence": { "sequence": "MERVLEDEAADDLAMRSPDLRPWASLLLADLALLWLLQGPLGALLPLGFPGLWLEGALRLGGLWGLLRLGGLLEGVGALLPILCLVNPLFLSLRALVLGALSAPLVRVAAATWAWLLLGYGAVGLSRALWAVLSPSGAKAEGQGQENRVLMWRLLKLSWPDLPFLVAAFSFLSLAVLGETVIPYYFGRVIDILGGDFDPDAFASAIFFVCLFSVGSSLCAGCRGSIFIFTMSRINLRIREMLFSSLLHQDLPFFQETKTGELNSRLSSDTKLMSNWLPYNTNVLSRSLVKVLGLYGFMLNLSPRLTFLSLFEVPLMIAAEKVYNARRQAVLWEIQDATAKAGQVVRESVGGLQTVRSFGAEEQEVCRYKEALERCRRLWWRRDLERALYLLLRRMLHLAMKVLLLNCALQQILAGDLTRGGLLSFLLYQEDMGNYMHTLVYMFGDMLSNVGAAEKVFRYLDRKPDLPPPGTLAPPTLQGRVNFQNVSFAYPSRPDQPALQGLTFTLSPGQMTALVGPNGSGKSTVAALLQNLYQPTEGQVLLDGKPVSEYEHHYLHRQVVLVGQEPVLFSGSVRDNITYGLKGCSDEKVLAAARAARAEEFIRELELGLDTEVGEKGSQLAVGQKQRLAIARALVRDPRVLILDEATSALDVECEQALQDWRAQGTRTVLVIAHRLQTVQSADQVLVLRQGRLQGLEQLMDGQDLYSWLVQQNRSVETPDTAGPAQGHLSDPE", "length": 733, "header": "tr|E1BJS0-1|F1MCG5_BOVIN Computationally mapped isoform of Antigen peptide transporter 2 OS=Bos taurus OX=9913 GN=TAP2 PE=3 SV=4 CANONICAL=F1MCG5-1" }, "locus": { "chromosome": "23", "start_pos": 7146266, "end_pos": 7139098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036293.6", "url": "https://www.ensembl.org/id/ENSBTAT00000036293.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036155.6", "url": "https://www.ensembl.org/id/ENSBTAP00000036155.6" } ] } }, { "isoform_ac": "F1MCG5-1", "url": "https://www.uniprot.org/uniprotkb/F1MCG5/entry", "sequence": { "sequence": "MRSPDLRPWASLLLADLALLWLLQGPLGALLPLGFPGLWLEGALRLGGLWGLLRLGGLLEGVGALLPILCLVNPLFLSLRALVLGALSAPLVRVAAATWAWLLLGYGAVGLSRALWAVLSPSGAKAEGQGQENRVLMWRLLKLSWPDLPFLVAAFSFLSLAVLGETVIPYYFGRVIDILGGDFDPDAFASAIFFVCLFSVGSSLCAGCRGSIFIFTMSRINLRIREMLFSSLLHQDLPFFQETKTGELNSRLSSDTKLMSNWLPYNTNVLSRSLVKVLGLYGFMLNLSPRLTFLSLFEVPLMIAAEKVYNARRQAVLWEIQDATAKAGQVVRESVGGLQTVRSFGAEEQEVCRYKEALERCRRLWWRRDLERALYLLLRRMLHLAMKVLLLNCALQQILAGDLTRGGLLSFLLYQEDMGNYMHTLVYMFGDMLSNVGAAEKVFRYLDRKPDLPPPGTLAPPTLQGRVNFQNVSFAYPSRPDQPALQGLTFTLSPGQMTALVGPNGSGKSTVAALLQNLYQPTEGQVLLDGKPVSEYEHHYLHRQVVLVGQEPVLFSGSVRDNITYGLKGCSDEKVLAAARAARAEEFIRELELGLDTEVGEKGSQLAVGQKQRLAIARALVRDPRVLILDEATSALDVECEQALQDWRAQGTRTVLVIAHRLQTVQSADQVLVLRQGRLQGLEQLMDGQDLYSWLVQQNRSVETPDTAGPAQGHLSDPE", "length": 719, "header": "tr|F1MCG5-1|F1MCG5_BOVIN Isoform 1 of Antigen peptide transporter 2 OS=Bos taurus OX=9913 GN=TAP2 PE=3 SV=2 CANONICAL=F1MCG5-1" }, "locus": { "chromosome": "23", "start_pos": 7146023, "end_pos": 7139098, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003953.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003953.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003953.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003953.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-983170", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983170", "resource": "Reactome", "description": "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RQ21-1", "protein_name": "Antigen peptide transporter 2", "gene_name": "TAP2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRLPDLRPWAALLLADSALLWLLQGPLEALLPRGLPGLWLEGILRLGGLWWLLRLGGLLGYVRTLLCPLCLVIPFFLSLRALVPGALSAPPARVASAPWSWLLLGSGAAGLSWAVWAVLSPPGAQEKKEDQENNRALMWRLLKLSWPDWPFLAAAFFFLVLAVLGETLIPYYSGLVIDILGGDFDPDAFVSAILFMSLFSVGSSLSAGCRGSAFTLVMSRINLRVREQLFSSLLHQDLAFFQETKTGELNSRLSSDTKLMSLWLPLNANVLLRSLVKVLGLFGFMLSLSPRLTLLSLLQMPLTIAAEKVYNARHLAVLREIQDAVARAGQVVREAVGDLQTVRSFGAEEEEVCRYKEALERCRQLWWRRDLEQALYLLLRRMLNLAMKVLLLSCGLQQILAGDLTQGGLLSFLLYQENMGSYVHTLVYVFGDMLSNVGAAEKVFYYLDRQPDLPPPGTLAPSTLKGVVKFQGVSFAYPNCPDQPVLKGLTFTLHPGQMTALVGPNGSGKSTVAALLQNLYQPTEGQVLLDEEPVSAYEHHYLHQQVVLVGQEPVLFSGSVRDNIAYGLKSCSDEKVMAAARAARAEEFINEMEHGLYTDVGEKGNQLAVGQKQRLAIARALVRDPRVLILDEATSALDAESEQALQDWKSHGNRTVLVIAHRLHTVQNADQILVLKQGELQEHAQLMEGEDLYSYLVRQNQRPEGGTPETLPPSQGHLSDPEELLL", "length": 726 }, "evidence": [ { "id": "F1MCG5", "url": "https://omabrowser.org/oma/group/F1MCG5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P36371-1", "protein_name": "Antigen peptide transporter 2", "gene_name": "Tap2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALSYLRPWVSLLLADMALLGLLQGSLGNLLPQGLPGLWIEGTLRLGVLWGLLKVGELLGLVGTLLPLLCLATPLFFSLRALVGGTASTSVVRVASASWGWLLAGYGAVALSWAVWAVLSPAGVQEKEPGQENRTLMKRLLKLSRPDLPFLIAAFFFLVVAVWGETLIPRYSGRVIDILGGDFDPDAFASAIFFMCLFSVGSSFSAGCRGGSFLFTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTSLMSRWLPFNANILLRSLVKVVGLYFFMLQVSPRLTFLSLLDLPLTIAAEKVYNPRHQAVLKEIQDAVAKAGQVVREAVGGLQTVRSFGAEEQEVSHYKEALERCRQLWWRRDLEKDVYLVIRRVMALGMQVLILNCGVQQILAGEVTRGGLLSFLLYQEEVGQYVRNLVYMYGDMLSNVGAAEKVFSYLDRKPNLPQPGILAPPWLEGRVEFQDVSFSYPRRPEKPVLQGLTFTLHPGTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGEPLTEYDHHYLHRQVVLVGQEPVLFSGSVKDNIAYGLRDCEDAQVMAAAQAACADDFIGEMTNGINTEIGEKGGQLAVGQKQRLAIARALVRNPRVLILDEATSALDAQCEQALQNWRSQGDRTMLVIAHRLHTVQNADQVLVLKQGRLVEHDQLRDGQDVYAHLVQQRLEA", "length": 702 }, "evidence": [ { "id": "F1MCG5", "url": "https://omabrowser.org/oma/group/F1MCG5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q03519-1", "protein_name": "Antigen peptide transporter 2", "gene_name": "TAP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLGFVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLSPPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQKLAQL", "length": 686 }, "evidence": [ { "id": "F1MCG5", "url": "https://omabrowser.org/oma/group/F1MCG5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "TAP1 binding", "id": "GO:0046978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046978", "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "pmid": "" }, { "name": "ABC-type peptide transporter activity", "id": "GO:0015440", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015440", "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "pmid": "" }, { "name": "ABC-type peptide antigen transporter activity", "id": "GO:0015433", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015433", "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "pmid": "" }, { "name": "MHC protein binding", "id": "GO:0042287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042287", "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "pmid": "" }, { "name": "antigen processing and presentation of endogenous peptide antigen via MHC class I", "id": "GO:0019885", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019885", "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "pmid": "" }, { "name": "MHC class I peptide loading complex", "id": "GO:0042824", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042824", "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "pmid": "" }, { "name": "TAP complex", "id": "GO:0042825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042825", "evidence": [ { "database": "UniProtKB", "id": "F1MCG5", "url": "https://www.uniprot.org/uniprotkb/F1MCG5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" }, { "start_pos": 471, "end_pos": 473, "annotation": "n_glycosylation_sequon" }, { "start_pos": 504, "end_pos": 506, "annotation": "n_glycosylation_sequon" }, { "start_pos": 562, "end_pos": 564, "annotation": "n_glycosylation_sequon" }, { "start_pos": 699, "end_pos": 701, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "65972", "name": "", "equation": "a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6DLE2-1", "F1MCG5-1" ], "evidence": [ { "id": "65972", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/65972" } ] }, { "id": "R-BTA-8951499", "name": "Loading of antigenic peptides on to class I MHC", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane, lumenal side of endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MCG5-1" ], "evidence": [ { "id": "R-BTA-8951499", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951499" } ] }, { "id": "R-BTA-983142", "name": "Formation of peptide loading complex (PLC)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane, lumenal side of endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MCG5-1" ], "evidence": [ { "id": "R-BTA-983142", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983142" } ] }, { "id": "R-BTA-983144", "name": "Transport of Antigen peptide in to ER", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-983032" ], "output_participant_list": [], "enzyme_list": [ "F1MCG5-1" ], "evidence": [ { "id": "R-BTA-983144", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983144" } ] }, { "id": "R-BTA-983161", "name": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. 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"MGRAAAAGRGAGGARQWLPWLGLCFWAAGAAAARGTDSGEVLPDSIPSAPGTLPHFIEEPDDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEESLDESSGLKVREVFINVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDEHIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVDGSWEVWSEWSVCSPECEHLRIRECTAPAPRNGGKFCEGLSQESENCTDGLCILGIENASDIALYSGLGAAVVAVAVLVIGITLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNPSMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSGTFPHGNNRSFTTVHARNKTPYIQNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPWAFQEVVSDERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQHDGDLDSLACALEEIGRTHTKLSNITDSQLDEADFTYSRQNGL", "length": 886, "header": "tr|A0A3Q1LZ42-1|F1MHX0_BOVIN Computationally mapped isoform of Netrin receptor UNC5 OS=Bos taurus OX=9913 GN=UNC5D PE=3 SV=2 CANONICAL=F1MHX0-1" }, "locus": { "chromosome": "27", "start_pos": 31370428, "end_pos": 30732560, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075682.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075682.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066081.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066081.2" } ] } }, { "isoform_ac": "A0A3Q1M879-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M879/entry", "sequence": { "sequence": "TDSGEVLPDSIPSAPGTLPHFIEEPDDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEESLDESSGLKVREVFINVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDEHIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVPCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITCTALCPVDGSWEVWSEWSVCSPECEHLRIRECTAPAPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQSIENASDIALYSGLGAAVVAVAVLVIGITLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNPSMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSGTFPHGNNRSFTTVHARNKTPYIQNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPWAFQEVVSDERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQHDGDLDSLACALEEIGRTHTKLSNITDSQLDEADFTYSRQNGL", "length": 918, "header": "tr|A0A3Q1M879-1|F1MHX0_BOVIN Computationally mapped isoform of Netrin receptor UNC5 OS=Bos taurus OX=9913 GN=UNC5D PE=3 SV=2 CANONICAL=F1MHX0-1" }, "locus": { "chromosome": "27", "start_pos": 31370428, "end_pos": 31087152, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085536.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085536.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070093.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070093.2" } ] } }, { "isoform_ac": "F1MHX0-1", "url": "https://www.uniprot.org/uniprotkb/F1MHX0/entry", "sequence": { "sequence": "MGRAAAAGRGAGGARQWLPWLGLCFWAAGAAAARGTDSGEVLPDSIPSAPGTLPHFIEEPDDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEESLDESSGLKVREVFINVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDEHIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVPCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITCTALCPVDGSWEVWSEWSVCSPECEHLRIRECTAPAPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQRWSRRGIENASDIALYSGLGAAVVAVAVLVIGITLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNPSMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSGTFPHGNNRSFTTVHARNKTPYIQNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPWAFQEVVSDERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQHDGDLDSLACALEEIGRTHTKLSNITDSQLDEADFTYSRQNGL", "length": 958, "header": "tr|F1MHX0-1|F1MHX0_BOVIN Isoform 1 of Netrin receptor UNC5 OS=Bos taurus OX=9913 GN=UNC5D PE=3 SV=3 CANONICAL=F1MHX0-1" }, "locus": { "chromosome": "27", "start_pos": 31370428, "end_pos": 30732560, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039849.6", "url": "https://www.ensembl.org/id/ENSBTAT00000039849.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039635.5", "url": "https://www.ensembl.org/id/ENSBTAP00000039635.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MHX0", "url": "https://www.uniprot.org/uniprotkb/F1MHX0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "F1MHX0", "url": "https://www.uniprot.org/uniprotkb/F1MHX0" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "F1MHX0", "url": "https://www.uniprot.org/uniprotkb/F1MHX0" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "F1MHX0", "url": "https://www.uniprot.org/uniprotkb/F1MHX0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "netrin receptor activity", "id": "GO:0005042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005042", "evidence": [ { "database": "UniProtKB", "id": "F1MHX0", "url": "https://www.uniprot.org/uniprotkb/F1MHX0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 353, "end_pos": 355, "annotation": "n_glycosylation_sequon" }, { "start_pos": 381, "end_pos": 383, "annotation": "n_glycosylation_sequon" }, { "start_pos": 510, "end_pos": 512, "annotation": "n_glycosylation_sequon" }, { "start_pos": 520, "end_pos": 522, "annotation": "n_glycosylation_sequon" }, { "start_pos": 530, "end_pos": 532, "annotation": "n_glycosylation_sequon" }, { "start_pos": 537, "end_pos": 539, "annotation": "n_glycosylation_sequon" }, { "start_pos": 892, "end_pos": 894, "annotation": "n_glycosylation_sequon" }, { "start_pos": 939, "end_pos": 941, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MHX0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 958, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MHX0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MHX0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MHX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHX0" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 166, "end_pos": 244, "start_aa": "Gln", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MHX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHX0" }, { "id": "PS51145", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51145" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ZU5", "eco_id": "ECO_0000259", "start_pos": 547, "end_pos": 687, "start_aa": "Leu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 117, "end_pos": 119 }, { "start_pos": 228, "end_pos": 230 }, { "start_pos": 353, "end_pos": 355 }, { "start_pos": 381, "end_pos": 383 }, { "start_pos": 510, "end_pos": 512 }, { "start_pos": 520, "end_pos": 522 }, { "start_pos": 530, "end_pos": 532 }, { "start_pos": 537, "end_pos": 539 }, { "start_pos": 892, "end_pos": 894 }, { "start_pos": 939, "end_pos": 941 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"uniprot_id": "F1MEU5_BOVIN", "mass": { "chemical_mass": 26500.0, "monoisotopic_mass": 26500.0 }, "refseq": { "ac": "XP_059742838", "name": "homeobox protein Hox-C6 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742838" }, "gene_names": [ { "name": "HOXC6", "type": "recommended", "evidence": [ { "id": "F1MEU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEU5" } ] }, { "name": "HOXC6", "type": "synonym", "evidence": [ { "id": "XP_059742838", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742838" } ] } ], "protein_names": [ { "name": "Homeobox C6", "type": "synonym", "evidence": [ { "id": "F1MEU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEU5/entry#names_and_taxonomy" } ] }, { "name": "homeobox protein Hox-C6 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059742838", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059742838" } ] } ], 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} ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MEU5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 231, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MEU5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MEU5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MEU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEU5" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": 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"id": "F1MCX1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCX1-1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARFGLPALFCTLAALSAALLAAEPKSKSCSEVRRLYVSKGFDKNDAPMHEINGDHLKICLQGYTCCSQEMEEKYSLQSKEDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFEELKRYYVAGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVARDVVSKVSVVNPTTQCTHALVKMMYCSHCQGLVTVKPCYNYCSNIMRGCLANQGDLDLEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQENSVQVSQKVFQGCGPPKPLPAGRISRSISEGTFSARFRPFHPEERPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSSVCNDERMAAGSGNEDDCWNGKGQSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQVMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCESQQCPSEFEYNATDHSGKSANDKASSAGVPAAAWPYLLPVFCILSLVMQREWR", "length": 556, "header": "tr|F1MCX1-1|F1MCX1_BOVIN Isoform 1 of Glypican 4 OS=Bos taurus OX=9913 GN=GPC4 PE=1 SV=2 CANONICAL=F1MCX1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M999-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M999/entry", "sequence": { "sequence": "MARFGLPALFCTLAALSAALLAAEPKSKSCSEVRRLYVSKGFDKNDAPMHEINEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFEELKRYYVAGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVARDVVSKVSVVNPTTQCTHALVKMMYCSHCQGLVTVKPCYNYCSNIMRGCLANQGDLDLEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQENSVQVSQKVFQGCGPPKPLPAGRISRSISEGTFSARFRPFHPEERPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSSVCNDERMAAGSGNEDDCWNGKGQSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQVMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCESQQCPSEFEYNATDHSGKSANDKASSAGVPAAAWPYLLPVFCILSLVMQREWR", "length": 503, "header": "tr|A0A3Q1M999-1|F1MCX1_BOVIN Computationally mapped isoform of Glypican 4 OS=Bos taurus OX=9913 GN=GPC4 PE=1 SV=1 CANONICAL=F1MCX1-1" }, "locus": { "chromosome": "X", "start_pos": 17256720, "end_pos": 17149244, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078781.2", "url": "https://www.ensembl.org/id/ENSBTAT00000078781.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066725.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066725.1" } ] } }, { "isoform_ac": "F1MCX1-1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1/entry", "sequence": { "sequence": "MARFGLPALFCTLAALSAALLAAEPKSKSCSEVRRLYVSKGFDKNDAPMHEINGDHLKICLQGYTCCSQEMEEKYSLQSKEDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFEELKRYYVAGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVARDVVSKVSVVNPTTQCTHALVKMMYCSHCQGLVTVKPCYNYCSNIMRGCLANQGDLDLEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQENSVQVSQKVFQGCGPPKPLPAGRISRSISEGTFSARFRPFHPEERPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSSVCNDERMAAGSGNEDDCWNGKGQSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQVMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCESQQCPSEFEYNATDHSGKSANDKASSAGVPAAAWPYLLPVFCILSLVMQREWR", "length": 556, "header": "tr|F1MCX1-1|F1MCX1_BOVIN Isoform 1 of Glypican 4 OS=Bos taurus OX=9913 GN=GPC4 PE=1 SV=2 CANONICAL=F1MCX1-1" }, "locus": { "chromosome": "X", "start_pos": 17256720, "end_pos": 17149244, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027510.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027510.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027510.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027510.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540179", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540179", "resource": "KEGG Pathway" }, { "id": "R-BTA-1971475", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1971475", "resource": "Reactome", "description": "Glycosaminoglycan-protein linkage region biosynthesis" }, { "id": "R-BTA-2022928", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022928", "resource": "Reactome", "description": "HS-GAG biosynthesis" }, { "id": "R-BTA-2024096", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2024096", "resource": "Reactome", "description": "HS-GAG degradation" }, { "id": "R-BTA-975634", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975634", "resource": "Reactome", "description": "Retinoid metabolism and transport" }, { "id": "R-BTA-9769735", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769735", "resource": "Reactome", "description": "Initiation of coagulation cascade" }, { "id": "R-BTA-9769739", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9769739", "resource": "Reactome", "description": "Regulation of clotting cascade" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RTE1-1", "protein_name": "Glypican 4", "gene_name": "GPC4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARFGLPALLCTLAALSAALLAAEPKSKSCSEVRRLYVSKGFDKNDAPTHEINGDHLKICPQGYTCCSQEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFEELKRYYVAGNVNLEEMLQDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVARDVVSKVSVVNPTAQCTHALLKMIYCSHCQGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQENSVQVSQKVFQGCGPPKPLPAGRLSRSISEGAFSARFRPFHPEERPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFEYNATEHSGKNAHDKASSAGAPARAQPYLLTAFGILSLVMPREWR", "length": 556 }, "evidence": [ { "id": "F1MCX1", "url": "https://omabrowser.org/oma/group/F1MCX1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O75487-1", "protein_name": "Glypican-4", "gene_name": "GPC4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARFGLPALLCTLAVLSAALLAAELKSKSCSEVRRLYVSKGFNKNDAPLHEINGDHLKICPQGSTCCSQEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPHHPEERPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFDYNATDHAGKSANEKADSAGVRPGAQAYLLTVFCILFLVMQREWR", "length": 556 }, "evidence": [ { "id": "F1MCX1", "url": "https://omabrowser.org/oma/group/F1MCX1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P51655-1", "protein_name": "Glypican-4", "gene_name": "Gpc4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARLGLLALLCTLAALSASLLAAELKSKSCSEVRRLYVSKGFNKNDAPLYEINGDHLKICPQDYTCCSQEMEEKYSLQSKDDFKTVVSEQCNHLQAIFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVAGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVARDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPYHPEQRPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSTVCNDERMAAGNENEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFEYNATDHSGKSANEKADSAGGAHAEAKPYLLAALCILFLAVQGEWR", "length": 557 }, "evidence": [ { "id": "F1MCX1", "url": "https://omabrowser.org/oma/group/F1MCX1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VUG1-1", "protein_name": "Dally-like, isoform A", "gene_name": "dlp", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLHQQQQQQHLHCRRKATATTTARLVIFSSPLLLLLLTTHLPPTLQADNGPAPQVAALAAPNPAGGVAGSSIIDQFSPNCSAVTHIFQARGIDAIEIPQKPSNERVLRYCESPSVGTCCTYNMETRMAMQSRQQLEGHTKDQISRMSGILGSKATKFKDIFTALLKESRTQFNSMFIRTYGVIYERNSYVFSDLFKELETYFANGRVDLLEVMDKFFNTLYQKMFTVLNTQYTFDENYMRCVSEHMKELKPFGDVPDKLSVQIKRSFVATRTYGQALTTASEVAKKVLNVRLNADCTGALTKMQHCGACKGYTEKPCTNYCVNVIKGCLHYQHEFDSEWENFAMAMDKVAERLLGSFNIVMVVEPLNIKISEAIMNFQDSGQDITNRVFQGCGRPKLKKMKRSISPKLQGVQILNARSPVEADTLDIDETLDEAIVLRERRAAEPGSQETSAQQSQEQGVGKSGNGGGGGGGNNRRQQQRRKQQQQRRKQQNNRDDNDDDDNESGGGREPILDRIVRDIRQRVKDYKKFWSNLPHSVCSNEDIASSSDVDGMCWNGHTIDRYMHSITTEHGSNPEFTGNPASTKQTAQMASQLSHLKNAIVHLRNAYNGQDVEWSEQEELPYAGSGAGSGSGSEDDEDDDEGSGLGPFEPSHKPDVERPSVDADNDDDEDAGGRGHMPTHTSRPTSGVDDKNPLIHTTHFDQDHNDLDEDHRQLDEDEDTDAGHDGANDNRSSDAPEKMTLRRALVVYLLPLYMAWFGGVCADLL", "length": 765 }, "evidence": [ { "id": "F1MCX1", "url": "https://omabrowser.org/oma/group/F1MCX1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MCX1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "F1MCX1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "F1MCX1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "F1MCX1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "F1MCX1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1MCX1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "F1MCX1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "F1MCX1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "F1MCX1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "F1MCX1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1" } ], "pmid": "" }, { "name": "synaptic membrane adhesion", "id": "GO:0099560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099560", "evidence": [ { "database": "UniProtKB", "id": "F1MCX1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1" } ], "pmid": "" }, { "name": "regulation of neurotransmitter receptor localization to postsynaptic specialization membrane", "id": "GO:0098696", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098696", "evidence": [ { "database": "UniProtKB", "id": "F1MCX1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1" } ], "pmid": "" }, { "name": "regulation of presynapse assembly", "id": "GO:1905606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905606", "evidence": [ { "database": "UniProtKB", "id": "F1MCX1", "url": "https://www.uniprot.org/uniprotkb/F1MCX1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 514, "end_pos": 516, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MCX1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 556, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MCX1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MCX1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": 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"count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MD59-1", "uniprot_ac": "F1MD59", "uniprot_id": "F1MD59_BOVIN", "mass": { "chemical_mass": 113733.0, "monoisotopic_mass": 113733.0 }, "refseq": { "ac": "NP_001193107", "name": "solute carrier family 12 member 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193107" }, "gene_names": [ { "name": "SLC12A3", "type": "recommended", "evidence": [ { "id": "F1MD59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ] }, { "name": "SLC12A3", "type": "synonym", "evidence": [ { "id": "NP_001193107", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193107" } ] } ], "protein_names": [ { "name": "Solute carrier family 12 member 3", "type": "recommended", "evidence": [ { "id": "F1MD59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD59/entry#names_and_taxonomy" } ] }, { "name": "Na-Cl symporter", "type": "synonym", "evidence": [ { "id": "F1MD59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD59/entry#names_and_taxonomy" } ] }, { "name": "Thiazide-sensitive sodium-chloride cotransporter", "type": "synonym", "evidence": [ { "id": "F1MD59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD59/entry#names_and_taxonomy" } ] }, { "name": "sodium chloride cotransporter", "type": "synonym", "evidence": [ { "id": "NP_001193107", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193107" } ] }, { "name": "solute carrier family 12 (sodium/chloride transporters), member 3", "type": "synonym", "evidence": [ { "id": "NP_001193107", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193107" } ] }, { "name": "solute carrier family 12 member 3", "type": "synonym", "evidence": [ { "id": "NP_001193107", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193107" } ] } ], "function": [ { "annotation": "Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MAS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAS3#function" }, { "database": "UniProtKB", "id": "ARBA00056815", "url": "https://www.uniprot.org/uniprotkb/ARBA00056815#function" }, { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC12A3", "url": "https://www.uniprot.org/uniprotkb/F1MD59", "locus": { "chromosome": "18", "start_pos": 24953998, "end_pos": 24914602, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006630", "url": "https://www.ensembl.org/id/ENSBTAG00000006630" } ] } } ], "crossref": [ { "id": "F1MD59", "url": "https://alphafold.ebi.ac.uk/entry/F1MD59", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006630", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006630", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "404171", "url": "https://www.ncbi.nlm.nih.gov/gene/404171", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002948", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002948", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018491", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018491", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:404171", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404171", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PWMITEQ", "url": "https://omabrowser.org/oma/group/PWMITEQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MAS3", "url": "https://www.orthodb.org/?gene=A0A3Q1MAS3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MD59", "url": "https://www.orthodb.org/?gene=F1MD59", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11827", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11827:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00324", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00324", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03522", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03522", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08403", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08403", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-426117", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-426117", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193107", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "73887", "url": "https://www.rhea-db.org/rhea/73887", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MAS3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAS3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MD59-1", "url": "https://www.uniprot.org/uniprotkb/F1MD59-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAELPVSEAPRDPALCSGRFTISTLLGGEEPPPPAAYDSSHPSHLTHGNTFYNRTFGYNTIDVVPAYEHYANSALPGEPRKVRPTLADLHSFLKQEGSHLHALAFDSRPSHEMTDGLVEDEAGINGEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGSPIVDPTNDIRIIGVVTVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEEKASKGFFSYRADIFVQNLVPEWRGMDGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTVSYLAISATIGSCVVRDASGGLNDTVTPGSGACEGLACGYGWNFTECAQQRSCRYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCLDQLYPLIGFFGKGYGKNNEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLMGPRKQRMPELRLIANGHTKWLNKRKIKAFYSDVLAEDLRSGVQVLMQAAGLGRMKPNILVIGFKKNWQSAHPATVEDYIGILHDAFDLNYGVCVMRMREGLNISEVMQAHINPMFDPAEDSKEARAGGAHLSVSGTVDPEALVQEEQASTVFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKKRWSKCRIRVFVGGQINRMDQERKAIISLLSKFRLGFHEVHVLPDINQKPRAEHIKRFEDMIAPFRLNDGFKDEATVTEMRRDCPWKISDEEINKNRIKSLRQVRLNEILLDYSRDAALVVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQENVLTFYCQ", "length": 1030, "header": "tr|F1MD59-1|F1MD59_BOVIN Isoform 1 of Solute carrier family 12 member 3 OS=Bos taurus OX=9913 GN=SLC12A3 PE=3 SV=3 CANONICAL=F1MD59-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MAS3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAS3/entry", "sequence": { "sequence": "MGAVSLWAHVVMFIAQSLATQEGSHLHALAFDSRPSHEMTDGLVEDEAGINGEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGSPIVDPTNDIRIIGVVTVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEEKASKGFFSYRADIFVQNLVPEWRGMDGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTVSYLAISATIGSCVVRDASGGLNDTVTPGSGACEGLACGYGWNFTECAQQRSCRYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCLDQLYPLIGFFGKGYGKNNEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLMGPRKQRMPELRLIANGHTKWLNKRKIKAFYSDVLAEDLRSGVQVLMQAAGLGRMKPNILVIGFKKNWQSAHPATVEDYIGILHDAFDLNYGVCVMRMREGLNISEVMQAHKDSKEARAGGAHLSVSGTVDPEALVQEEQASTVFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKKRWSKCRIRVFVGGQINRMDQERKAIISLLSKFRLGFHEVHVLPDINQKPRAEHIKRFEDMIAPFRLNDGFKDEATVTEMRRDCPWKISDEEINKNRIKSLRQVRLNEILLDYSRDAALVVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQENVLTFYCQ", "length": 948, "header": "tr|A0A3Q1MAS3-1|F1MD59_BOVIN Computationally mapped isoform of Solute carrier family 12 member 3 OS=Bos taurus OX=9913 GN=SLC12A3 PE=3 SV=2 CANONICAL=F1MD59-1" }, "locus": { "chromosome": "18", "start_pos": 24953715, "end_pos": 24915053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076302.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076302.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067336.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067336.2" } ] } }, { "isoform_ac": "F1MD59-1", "url": "https://www.uniprot.org/uniprotkb/F1MD59/entry", "sequence": { "sequence": "MAELPVSEAPRDPALCSGRFTISTLLGGEEPPPPAAYDSSHPSHLTHGNTFYNRTFGYNTIDVVPAYEHYANSALPGEPRKVRPTLADLHSFLKQEGSHLHALAFDSRPSHEMTDGLVEDEAGINGEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGSPIVDPTNDIRIIGVVTVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEEKASKGFFSYRADIFVQNLVPEWRGMDGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTVSYLAISATIGSCVVRDASGGLNDTVTPGSGACEGLACGYGWNFTECAQQRSCRYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCLDQLYPLIGFFGKGYGKNNEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLMGPRKQRMPELRLIANGHTKWLNKRKIKAFYSDVLAEDLRSGVQVLMQAAGLGRMKPNILVIGFKKNWQSAHPATVEDYIGILHDAFDLNYGVCVMRMREGLNISEVMQAHINPMFDPAEDSKEARAGGAHLSVSGTVDPEALVQEEQASTVFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKKRWSKCRIRVFVGGQINRMDQERKAIISLLSKFRLGFHEVHVLPDINQKPRAEHIKRFEDMIAPFRLNDGFKDEATVTEMRRDCPWKISDEEINKNRIKSLRQVRLNEILLDYSRDAALVVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQENVLTFYCQ", "length": 1030, "header": "tr|F1MD59-1|F1MD59_BOVIN Isoform 1 of Solute carrier family 12 member 3 OS=Bos taurus OX=9913 GN=SLC12A3 PE=3 SV=3 CANONICAL=F1MD59-1" }, "locus": { "chromosome": "18", "start_pos": 24953715, "end_pos": 24914602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008705.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008705.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008705.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008705.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 410, "start_aa": "Thr", "end_pos": 410, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr410", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:404171", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:404171", "resource": "KEGG Pathway" }, { "id": "R-BTA-426117", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-426117", "resource": "Reactome", "description": "Cation-coupled Chloride cotransporters" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BHP2-1", "protein_name": "Solute carrier family 12 member 3", "gene_name": "SLC12A3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAELSVSETPRDPALCSGRFTISTLLGGDEPPLPAAYDSSHPSHLTHGSTFYMRTFGYNTLDVVPAYEHYANSTLPGEPRKVRPTLADLHSFLKQEGSHLHALAFDSRPSHEMTDGLVEDEAATKAEKNPEEPVRFGWIKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGTPIVDPINDIRIIGVVTITVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGIDGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGLGTCEGLACGYGWNFTECAQQHSCRFGLMNYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCVDQLYPLIGFFGKGYGKNNEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAVISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRRPELRLIANGHTKWLNKRKIKAFYSDVIAEDLRSGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGLLHDAFDFNYGVCVMRMREGLNISKVMQAHINPVFDPAEDSKDASAGGSRPSVSGTADPEALVREEQASTVFQSEQGKKTIDIYWLFDDGGLTLLVPYLLGRKKRWSKCRIRVFVGGQINRMDQERKAIISLLSKFRLRFHEVHVLPDINQKPRAEHTKRFEDMVAPFRLNDGFKDEATVSEMRRDCPWKISDEEINKNRIKSLRQVRLNEILLDYSRDAALVVVTLPIGRQGKCPSSLYMAWLETLSQDLRPPVVLIRGNQENVLTFYCQ", "length": 1030 }, "evidence": [ { "id": "F1MD59", "url": "https://omabrowser.org/oma/group/F1MD59/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7FIT3-1", "protein_name": "Solute carrier family 12 member 3", "gene_name": "Slc12a3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAELPVTEMPGDALCSGRFTISTLLGGDEPPAAACDSSQPSHLTHGSTLYMRTFGYNTIDVVPAYEHYANSALPGETRKMRPTLADLHSFLKQEGSHLHALAFDGRSGHELTDGLVEDETGTNSEKSPGEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWLIILLSVMVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGTPIVDPINDIRIIGVVTVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPASEDKASKGFYSYHGDIFVQNLVPDWRGIDGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGDLNDTVTPGPGTCEGLACGYGWNFTECSQQHSCRYGLINYYQTMSMVSAFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYSKWAALFGAVISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAHSYNLALSYSMGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVSTFTQNLSLMICGHVLIGPRKQRVPEFQHIASGHTKWLNKRKIKAFYSDVIAEDLRSGVQILMQASGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNFGVCVMRMREGLNVSEAMQMHIKKLKMFDPAEEGNGASGGWAPSVSVTAAPEALVQEEQASTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLHRKKRWGKCKIRVFVGGQINRMDEERKAIISLLSKFRLGFHEVHVLPDINQKPQAEHIKRFEDMIAPFRLNDGFKDEATVAEMRRDCPWKISDEEINKNRVKSLRQVRLNEILLDYSRDAALIILTLPIGRKGKCPSSLYMAWLEILSQDLRPPVILIRGNQENVLTFYCQ", "length": 1029 }, "evidence": [ { "id": "F1MD59", "url": "https://omabrowser.org/oma/group/F1MD59/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P55017-1", "protein_name": "Solute carrier family 12 member 3", "gene_name": "SLC12A3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIAVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAHINPVFDPAEDGKEASARVDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQENVLTFYCQ", "length": 1021 }, "evidence": [ { "id": "F1MD59", "url": "https://omabrowser.org/oma/group/F1MD59/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P55018-1", "protein_name": "Solute carrier family 12 member 3", "gene_name": "Slc12a3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAELPVTEMPGDALCSGRFTISTLLGGDEPPPAACDNSQPSHLTHGSTLYLRTFGYNTIDVVPAYEHYANSALPGEPRKVRPTLADLHSFLKQEGSHLHALAFDGRPGHELTDGLVEDETGANSEKSPGEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWLIILLSVMVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQENGTPIVDPINDIRIIGVVTVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPASKDKASKGFYSYHGDIFVQNLVPDWRGIDGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGDVNDTITPGPGLCEGLACGYGWNFTECSQQHSCRYGLINYYQTMSMVSAFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAVISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVSTFTQNLSLMICGHVLIAPGKQRVPELRLIASGHTKWLNKRKIKAFYSDVIAEDLRSGVQILMQASGLGRMKPNILVVGFKKNWQSAHPATLEDYIGILHDAFDFNYGVCIMRMREGLNVSEALQTHTAPEALVQEEQTSTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLHRKKRWGKCKIRVFVGGQINRMDEERKAIISLLSKFRLGFHEVHVLPDINQKPQVEHTKRFEDMIAPFRLNDGFKDEATVAEMRRDYPWKISDEEINKNRIKSLRQVRLNEILLDYSRDAALIILTLPIGRKGKCPSSLYMAWLETLSQDLSPPVLLIRGNQENVLTFYCQ", "length": 1002 }, "evidence": [ { "id": "F1MD59", "url": "https://omabrowser.org/oma/group/F1MD59/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P59158-1", "protein_name": "Solute carrier family 12 member 3", "gene_name": "Slc12a3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAELPVTELPGDALCSGRFTISTLMGGDEPPPAACDSSQPSHLTHGSTLYMRTFGYNTIDVVPAYEHYANSALPGEPRKVRPTLADLHSFLKQEGSHLHALAFDGRQGRELTDGLVEDETGTNSEKSPGEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWLIILLSVMVTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGTPIVDPINDIRIIGVVTVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPASEDKASKGFYSYHGDIFVQNLVPDWRGIDGSFFGMFSIFFPSATGILAGANISGDLKDPAVAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGDVNDTMTPGPGPCEGLACGYGWNFTECSQQRSCRYGLINYYQTMSMVSAFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNREPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFRYYSKWAALFGAVISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVSTFTQNLSLMICGHVLIGPGKQRVPELRLIASGHTKWLNKRKIKAFYSDVIAEDLRSGVQILMQASGLGRMKPNILVVGFKRNWQSAHPATVEDYIGVLHDAFDFNYGVCVMRMREGLNVSEALQTHTTPEALIQEEQASTIFQSEQGKKTIDIYWLFDDGGLTLLIPYLLHRKKRWGKCKIRVFVGGQINRMDEERKAIISLLSKFRLGFHEVHVLPDINQKPQAEHTKRFEDMIAPFRLNDGFKDEATVTEMRRDCPWKISDEEINKNRIKSLRQVRLSEILLDYSRDAALIILTLPIGRKGKCPSSLYMAWLETLSQDLRPPVLLIRGNQENVLTFYCQ", "length": 1002 }, "evidence": [ { "id": "F1MD59", "url": "https://omabrowser.org/oma/group/F1MD59/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" }, { "name": "sodium:chloride symporter activity", "id": "GO:0015378", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015378", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" }, { "name": "sodium:potassium:chloride symporter activity", "id": "GO:0008511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008511", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "cell volume homeostasis", "id": "GO:0006884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006884", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" }, { "name": "chloride transmembrane transport", "id": "GO:1902476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902476", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" }, { "name": "sodium ion transmembrane transport", "id": "GO:0035725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035725", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" }, { "name": "potassium ion homeostasis", "id": "GO:0055075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055075", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" }, { "name": "sodium ion homeostasis", "id": "GO:0055078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055078", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" }, { "name": "potassium ion import across plasma membrane", "id": "GO:1990573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990573", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" }, { "name": "chloride ion homeostasis", "id": "GO:0055064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055064", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" }, { "name": "response to aldosterone", "id": "GO:1904044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904044", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" }, { "name": "response to salt", "id": "GO:1902074", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902074", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" }, { "name": "renal sodium ion absorption", "id": "GO:0070294", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070294", "evidence": [ { "database": "UniProtKB", "id": "F1MD59", "url": "https://www.uniprot.org/uniprotkb/F1MD59" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 359, "end_pos": 361, "annotation": "n_glycosylation_sequon" }, { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" }, { "start_pos": 426, "end_pos": 428, "annotation": "n_glycosylation_sequon" }, { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" }, { "start_pos": 544, "end_pos": 546, "annotation": "n_glycosylation_sequon" }, { "start_pos": 668, "end_pos": 670, "annotation": "n_glycosylation_sequon" }, { "start_pos": 781, "end_pos": 783, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "73887", "name": "", "equation": "chloride(out) + Na(+)(out) = chloride(in) + Na(+)(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "73887", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/73887" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MD59-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1030, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MD59-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MD59" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MD59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD59" }, { "id": "PF08403", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08403" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amino acid permease N-terminal", "eco_id": "ECO_0000259", "start_pos": 46, "end_pos": 116, "start_aa": "Thr", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MD59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD59" }, { "id": "PF00324", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00324" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amino acid permease/ SLC12A", "eco_id": "ECO_0000259", "start_pos": 141, "end_pos": 646, "start_aa": "Gly", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MD59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD59" }, { "id": "PF03522", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03522" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SLC12A transporter C-terminal", "eco_id": "ECO_0000259", "start_pos": 655, "end_pos": 791, "start_aa": "Arg", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 410 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 359, "end_pos": 361 }, { "start_pos": 406, "end_pos": 408 }, { "start_pos": 426, "end_pos": 428 }, { "start_pos": 53, "end_pos": 55 }, { "start_pos": 544, "end_pos": 546 }, { "start_pos": 668, "end_pos": 670 }, { "start_pos": 781, "end_pos": 783 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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}, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MIH4-1", "uniprot_ac": "F1MIH4", "uniprot_id": "F1MIH4_BOVIN", "mass": { "chemical_mass": 48962.0, "monoisotopic_mass": 48962.0 }, "refseq": {}, "gene_names": [ { "name": "CLIC5", "type": "recommended", "evidence": [ { "id": "F1MIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIH4" } ] } ], "protein_names": [ { "name": "Chloride intracellular channel protein", "type": "recommended", "evidence": [ { "id": "F1MIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIH4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MIH4", "url": "https://www.uniprot.org/uniprotkb/F1MIH4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLIC5", "url": "https://www.uniprot.org/uniprotkb/F1MIH4", "locus": { "chromosome": "23", "start_pos": 19158778, "end_pos": 19350762, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010244", "url": "https://www.ensembl.org/id/ENSBTAG00000010244" } ] } } ], "crossref": [ { "id": "F1MIH4", "url": "https://alphafold.ebi.ac.uk/entry/F1MIH4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010244", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010244", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03061", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03061", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd10297", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10297", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002946", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053823", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053823", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "XKPADLH", "url": "https://omabrowser.org/oma/group/XKPADLH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45476", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45476", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45476:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45476:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13410", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13410", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22441", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22441", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "29823", "url": "https://www.rhea-db.org/rhea/29823", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MD28", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MD28-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWK0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8K9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8K9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCR9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJI7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMU0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMU0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIH4", "url": "https://www.uniprot.org/uniprotkb/F1MIH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIH4-1", "url": "https://www.uniprot.org/uniprotkb/F1MIH4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNDENYSTTIYNRVQTERVYEDSDPAENGGPLYDEVHEDVRREDNLYVNELENQEYDSVAVYPVGHQGRTSASLQPETGEYVLPDEPYSKAQDPHPGEPTEDEDISLEELLSPTKDQESDSEEPQASDPEEPQASDPEEPQGPDPEEPQENGSEMEADLPSPSSFTIQNSRAFSTREISPTSYSADDVSEGNESASANPEINLFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPRLAAKHRESNTAGIDIFAKFSAYIKNTKQQSNAALERGLTKALKKLDDYLNTPLPEEIDADTRGDDEKGSRRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDFPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVAKRLSRS", "length": 437, "header": "tr|F1MIH4-1|F1MIH4_BOVIN Isoform 1 of Chloride intracellular channel protein OS=Bos taurus OX=9913 GN=CLIC5 PE=3 SV=1 CANONICAL=F1MIH4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MD28-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD28/entry", "sequence": { "sequence": "MKGALPGSSSSSGRSAGPGAAEVAPPRPGTLAPGADGMTDAATANGDDRDPEIELFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPRLAAKHRESNTAGIDIFAKFSAYIKNTKQQSNAALERGLTKALKKLDDYLNTPLPEEIDADTRGDDEKGSRRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDFPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVAKRLSRS", "length": 289, "header": "tr|A0A3Q1MD28-1|F1MIH4_BOVIN Computationally mapped isoform of Chloride intracellular channel protein OS=Bos taurus OX=9913 GN=CLIC5 PE=3 SV=2 CANONICAL=F1MIH4-1" }, "locus": { "chromosome": "23", "start_pos": 19295253, "end_pos": 19185153, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073323.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073323.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066719.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066719.2" } ] } }, { "isoform_ac": "A0AAA9RWK0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWK0/entry", "sequence": { "sequence": "MTDAATANGDDRDPEIELFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPRLAAKHRESNTAGIDIFAKFSAYIKNTKQQSNAALERGLTKALKKLDDYLNTPLPEEIDADTRGDDEKGSRRKFLDGDELTLADCNLLPKLHVVKVRALYLWVPPRSFIEGPGLLRG", "length": 219, "header": "tr|A0AAA9RWK0-1|F1MIH4_BOVIN Computationally mapped isoform of Chloride intracellular channel protein OS=Bos taurus OX=9913 GN=CLIC5 PE=3 SV=1 CANONICAL=F1MIH4-1" }, "locus": { "chromosome": "23", "start_pos": 19294675, "end_pos": 19191259, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128153.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128153.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076813.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076813.1" } ] } }, { "isoform_ac": "A0AAA9S8K9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8K9/entry", "sequence": { "sequence": "MNDENYSTTIYNRVQTERVYEDSDPAENGGPLYDEVHEDVRREDNLYVNELENQEYDSVAVYPVGHQGRTSASLQPETGEYVLPDEPYSKAQDPHPGEPTEDEDISLEELLSPTKDQESDSEEPQASDPEEPQGPDPEEPQENGSEMEADLPSPSSFTIQNSRAFSTREISPTSYSADDVSEGNESASANPEINLFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPRLAAKHRESNTAGIDIFAKFSAYIKNTKQQSNAALERGLTKALKKLDDYLNTPLPEEIDADTRGDDEKGSRRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDFPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVAKRLSRS", "length": 429, "header": "tr|A0AAA9S8K9-1|F1MIH4_BOVIN Computationally mapped isoform of Chloride intracellular channel protein OS=Bos taurus OX=9913 GN=CLIC5 PE=3 SV=1 CANONICAL=F1MIH4-1" }, "locus": { "chromosome": "23", "start_pos": 19350608, "end_pos": 19185153, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107904.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107904.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082380.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082380.1" } ] } }, { "isoform_ac": "A0AAA9TCR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCR9/entry", "sequence": { "sequence": "MTDAATANGDDRDPEIELFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPRLAAKHRESNTAGIDIFAKFSAYIKNTKQQSNAALERGLTKALKKLDDYLNTPLPEEIDADTRGDDEKGSRRKFLDGDELTLADCNLLPKLHVVKLSLCW", "length": 202, "header": "tr|A0AAA9TCR9-1|F1MIH4_BOVIN Computationally mapped isoform of Chloride intracellular channel protein OS=Bos taurus OX=9913 GN=CLIC5 PE=3 SV=1 CANONICAL=F1MIH4-1" }, "locus": { "chromosome": "23", "start_pos": 19294675, "end_pos": 19158862, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107208.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107208.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094655.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094655.1" } ] } }, { "isoform_ac": "A0AAA9TJI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJI7/entry", "sequence": { "sequence": "MTDAATANGDDRDPEIELFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPRLAAKHRESNTAGIDIFAKFSAYIKNTKQQSNAALERGLTKALKKLDDYLNTPLPEEIDADTRGDDEKGSRRKFLDGDELTLADCNLLPKLHVVKDEVAPLWVI", "length": 206, "header": "tr|A0AAA9TJI7-1|F1MIH4_BOVIN Computationally mapped isoform of Chloride intracellular channel protein OS=Bos taurus OX=9913 GN=CLIC5 PE=3 SV=1 CANONICAL=F1MIH4-1" }, "locus": { "chromosome": "23", "start_pos": 19294675, "end_pos": 19189218, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092225.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092225.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098625.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098625.1" } ] } }, { "isoform_ac": "A0AAA9TMU0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMU0/entry", "sequence": { "sequence": "MTDAATANGDDRDPEIELFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPRLAAKHRESNTAGIDIFAKFSAYIKNTKQQSNAALERGLTKALKKLDDYLNTPLPEEIDADTRGDDEKGSRRKFLDGDELTLADCNLLPKLHVVKTHLLISYSHSLGSLCVGGAWNRGRSRQEKGGARERRTKRNSFY", "length": 240, "header": "tr|A0AAA9TMU0-1|F1MIH4_BOVIN Computationally mapped isoform of Chloride intracellular channel protein OS=Bos taurus OX=9913 GN=CLIC5 PE=3 SV=1 CANONICAL=F1MIH4-1" }, "locus": { "chromosome": "23", "start_pos": 19294675, "end_pos": 19158781, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121598.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121598.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097665.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097665.1" } ] } }, { "isoform_ac": "F1MIH4-1", "url": "https://www.uniprot.org/uniprotkb/F1MIH4/entry", "sequence": { "sequence": "MNDENYSTTIYNRVQTERVYEDSDPAENGGPLYDEVHEDVRREDNLYVNELENQEYDSVAVYPVGHQGRTSASLQPETGEYVLPDEPYSKAQDPHPGEPTEDEDISLEELLSPTKDQESDSEEPQASDPEEPQASDPEEPQGPDPEEPQENGSEMEADLPSPSSFTIQNSRAFSTREISPTSYSADDVSEGNESASANPEINLFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPRLAAKHRESNTAGIDIFAKFSAYIKNTKQQSNAALERGLTKALKKLDDYLNTPLPEEIDADTRGDDEKGSRRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDFPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVAKRLSRS", "length": 437, "header": "tr|F1MIH4-1|F1MIH4_BOVIN Isoform 1 of Chloride intracellular channel protein OS=Bos taurus OX=9913 GN=CLIC5 PE=3 SV=1 CANONICAL=F1MIH4-1" }, "locus": { "chromosome": "23", "start_pos": 19350608, "end_pos": 19185153, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013537.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013537.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013537.4", "url": "https://www.ensembl.org/id/ENSBTAP00000013537.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1MIH4", "url": "https://www.uniprot.org/uniprotkb/F1MIH4" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1MIH4", "url": "https://www.uniprot.org/uniprotkb/F1MIH4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MIH4", "url": "https://www.uniprot.org/uniprotkb/F1MIH4" } ], "pmid": "" }, { "name": "chloride channel complex", "id": "GO:0034707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034707", "evidence": [ { "database": "UniProtKB", "id": "F1MIH4", "url": "https://www.uniprot.org/uniprotkb/F1MIH4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MIH4", "url": "https://www.uniprot.org/uniprotkb/F1MIH4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "F1MIH4", "url": "https://www.uniprot.org/uniprotkb/F1MIH4" } ], "pmid": "" }, { "name": "chloride channel activity", "id": "GO:0005254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005254", "evidence": [ { "database": "UniProtKB", "id": "F1MIH4", "url": "https://www.uniprot.org/uniprotkb/F1MIH4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29823", "name": "", "equation": "chloride(in) = chloride(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MN01-1", "Q5E9B7-1", "Q9XSA7-1", "P35071-1", "P35526-1" ], "evidence": [ { "id": "29823", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29823" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] }, { "uniprot_ac": "Q5E9B7", "gene_name": "CLIC1", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "Q5E9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B7" } ] }, { "ec_number": "1.8.5.1", "activity": "L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate.", "evidence": [ { "id": "Q5E9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9B7" } ] } ] }, { "uniprot_ac": "Q9XSA7", "gene_name": "CLIC4", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "Q9XSA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9XSA7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MIH4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 437, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MIH4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MIH4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIH4" }, { "id": "PS50405", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50405" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GST C-terminal", "eco_id": "ECO_0000259", "start_pos": 263, "end_pos": 427, "start_aa": "Asn", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 151, "end_pos": 153 }, { "start_pos": 192, "end_pos": 194 }, { "start_pos": 235, "end_pos": 237 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MDU9-1", "uniprot_ac": "F1MDU9", "uniprot_id": "F1MDU9_BOVIN", "mass": { "chemical_mass": 242623.0, "monoisotopic_mass": 242623.0 }, "refseq": {}, "gene_names": [ { "name": "HEATR1", "type": "recommended", "evidence": [ { "id": "F1MDU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ] } ], "protein_names": [ { "name": "HEAT repeat-containing protein 1", "type": "recommended", "evidence": [ { "id": "F1MDU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDU9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in nucleolar processing of pre-18S ribosomal RNA.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RTK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTK9#function" }, { "database": "UniProtKB", "id": "RU367065", "url": "https://www.uniprot.org/uniprotkb/RU367065#function" }, { "database": "UniProtKB", "id": "A0AAA9RYM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYM1#function" }, { "database": "UniProtKB", "id": "A0AAA9SF10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF10#function" }, { "database": "UniProtKB", "id": "A0AAA9SR68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR68#function" }, { "database": "UniProtKB", "id": "A0A3Q1MF36", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF36#function" }, { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HEATR1", "url": "https://www.uniprot.org/uniprotkb/F1MDU9", "locus": { "chromosome": "28", "start_pos": 9193305, "end_pos": 9244384, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044100", "url": "https://www.ensembl.org/id/ENSBTAG00000044100" } ] } } ], "crossref": [ { "id": "ENSBTAG00000044100", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044100", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012954", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012954", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040191", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040191", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056473", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056473", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13457", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13457", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13457:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13457:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08146", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08146", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12397", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12397", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23243", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23243", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MF36", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MF36-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF36-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF10", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR68-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDU9-1", "url": "https://www.uniprot.org/uniprotkb/F1MDU9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSLAQQLQRLALPQSDSSLLSRDEVASLLFDPKEAATIDRDTAFAIVFLGCTGLEELLGIDPSFEQFEAPLFSQLAKTLERSVQTKAVNKQLDENISLFLIHLSPYFLLKPAQKCLEWLIHRFHIHLYNQDSLIACVLPYHETRIFVRVIQLLKINNSKHKWFWLLPIKQSGVPLAKGTLVTHCYKDLGFMDFICSLVTKSVKVFAEYPGSSSQLRVLLTFYASTIVSALVAAETLSDNIVAKLFPYIQKGLKSSLPDYRAATYMIICQISVKVTMEDTFVNSLASQIIRTLIRIPSLIKDGLSCLIVLLQRQKPESLGKKPFPHLCNVPNLITLLHGISETYDISPLLRYMLPHLVVSMINQITGEETEEMDGQVYRRLLEAILTNISLKNNLDHLLAGLLFEEYISYSSQDKVDSDKVSLLNEQFLPLIRLLESRYPKTLDAVLEERLKEITDLKKQELFHQFISLSTSGGKYQFLADSDTSLMLSLNHPLAPVRLLAINHLKNVMTTPEESIDESFIKEAILTRLGDDSVDVVLSAVSAFEVFKQHFSSEVTVSHLLNLFQRAELSKNRGWYKVLEIAAGILVKEEILGENDQLSNQVVVHLLPFMIINSDDMESAEMKMAVYLSKSGICSLHPLLRGWKEALENVIKSTKSEELIGVANQKMIELLADNINSGNPSSMLKMVEDLIGVGEKESFSLKQKVTFHVVMAVLVSCCSSLKETHFPFATRVFSLLQKKIKKLENVITTVEISSEWHFELMMDRGIPLELWAHYVKQLKTAQRIAVEDSVLLLFSLKNFIHTLKAPKSFPKDDTWWNPEQLQEDSRDYLRLLIGLFETVLSGADAIHFRVLMKLFIKVHLEDVFQLFKFLSVLWTYGSSLSNPLNCRVTAALQTQALYVGCALLSSQKAQCEHQLASASSPVVVSLLINLGSPIKEVRRAAIHCLQVLSGVASQFHLVIDHVVPKAEEITSDATYVVQDLATLFEELQSEKKLKSHQKLSETLKNLLHCVYSCPSYVTKDLMKVLQDINNELVLSQLLSMIEQLLEKSQKEPAAVLKDEAIALHLILGKYNEYSASLLHKDPKSLDIFIKALHTTKELCMGMPAIQITALEKITKPFFAAITDEKVQQKLLCVLFDLLVNCKNSHCSQTVSSVFKGISVNAEQVRIELEPPDKAKSLGTIQQTRRQKMQHKKSQDQESVQEVGGSYWQRVTLILELLQHKKKLKNPQILIPTLFNLLSRCLEPLPPEQGSMEYTKQLILSCLLNICQKLSPEGGRIPKDVLDEEKFNVELIVQCIRVSEMPQTHHHALLLLGTVAGIFPDKVLHNIMSIFTFMGANVMRLDDTYSFQVINKTVKMVIPALIQSDGGDSAEVTRNVEDIVVKIINVFVDALPHVPEHRRLPVLVQLVDTLGAERFLWVLLVLLFEQYVTKTVLAAAYGEKDAILEADTEFWISVCCEFSVQHQIQSLMTILEYLLKLPEEKEETIPKSVSNKSEPQEEMLQVFNIDAHTSKQLRHFKFLSVSFMSQLLASNNFIRKVVESGGPQVLTGLEQRLLETVLGYINAVAQSMERNADKLTGKFWRALLSKAYDMLDKVNALLPTETFIPVIRGLLENPLPSVRRKALDLLNNKLQQKTSWKKKIIYHFLDLVPVLVAMVKHKRKTLEDQPINRQTALYTLKLLCKNFGAENPEPFVPVLHTTVKLIALGAKEEKNVLGSALLCVAEVVSTLEALAIPQLPSLMPPLLTTMRSTRELVSGEVYLLSALAALQKVVETLPHFISPYLEGVLSQVIHLEKITSEMGPASQANVRLTSLKKTLATMLSPRVLLPAINKTYKQIEKNWKNLMGPFMSVLREHIGVMRKEELASHQPQLTTFFLEALDFRTQHAENDLEEIGKTENYIIDCLVAMVVKLSEVTFRPLFFKLFDWAKTEDAPKDRLLTFYNLADCIAEKLKGLFTLFAGHLVKPFADTLNQVNISKTDEAFFDSENDPEKCCLLLQFILNCLYKIFLFDTQHFLSKERAEALMVPLVDQLENRLGGEEKFQERVTKHLIPCLAQFSVAMADDSLWKPLNYQILLKTRDSSPKVRFAALITVLALAEKLRENYIVLLPESIPFLAELMEDECEEVEHQCQKTIQQLETLLGEPLQSYF", "length": 2145, "header": "tr|F1MDU9-1|F1MDU9_BOVIN Isoform 1 of HEAT repeat-containing protein 1 OS=Bos taurus OX=9913 GN=HEATR1 PE=3 SV=4 CANONICAL=F1MDU9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MF36-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MF36/entry", "sequence": { "sequence": "MTSLAQQLQRLALPQSDSSLLSRDEVASLLFDPKEAATIDRDTAFAIGCTGLEELLGIDPSFEQFEAPLFSQLAKTLERSVQTKAVNKQLDENISLFLIHLSPYFLLKPAQKCLEWLIHRFHIHLYNQDSLIACVLPYHETRIFVRVIQLLKINNSKHKWFWLLPIKQSGVPLAKGTLVTHCYKDLGFMDFICSLVTKSVKVFAEYPGSSSQLRVLLTFYASTIVSALVAAETLSDNIVAKLFPYIQKGLKSSLPDYRAATYMIICQISVKVTMEDTFVNSLASQIIRTLIRIPSLIKDGLSCLIVLLQRQKPESLGKKPFPHLCNVPNLITLLHGISETYDISPLLRYMLPHLVVSMINQITGEETEEMDGQVYRRLLEAILTNISLKNNLDHLLAGLLFEEYISYSSQDKVDSDKVSLLNEQFLPLIRLLESRYPKTLDAVLEERLKEITDLKKQELFHQFISLSTSGGKYQFLADSDTSLMLSLNHPLAPVRLLAINHLKNVMTTPEESIDESFIKEAILTRLGDDSVDVVLSAVSAFEVFKQHFSSEVTVSHLLNLFQRAELSKNRGWYKVLEIAAGILVKEEILGENDQLSNQVVVHLLPFMIINSDDMESAEMKMAVYLSKSGICSLHPLLRGWKEALENVIKSTKSEELIGVANQKMIELLADNINSGNPSSMLKMEISSEWHFELMMDRGIPLELWAHYVKQLKTAQRIAVEDSVLLLFSLKNFIHTLKAPKSFPKDDTWWNPEQLQEDSRDYLRLLIGLFETVLSGADAIHFRVLMKLFIKVHLEDVFQLFKFLSVLWTYGSSLSNPLNCRVTAALQTQALYVGCALLSSQKAQCEHQLASASSPVVVSLLINLGSPIKEVRRAAIHCLQVLSGVASQFHLVIDHVVPKAEEITSDATYVVQDLATLFEELQSEKKLKSHQKLSETLKNLLHCVYSCPSYVTKDLMKVLQDINNELVLSQLLSMIEQLLEKSQKEPAAVLKDEAIALHLILGKYNEYSASLLHKDPKSLDIFIKALHTTKELCMGMPAIQITALEKITKPFFAAITDEKVQQKLLCVLFDLLVNCKNSHCSQTVSSVFKGISVNAEQVRIELEPPDKAKSLGTIQQTRRQKMQHKKSQDQESVQEVGGSYWQRVTLILELLQHKKKLKNPQILIPTLFNLLSRCLEPLPPEQGSMEYTKQLILSCLLNICQKLSPEGGRIPKDVLDEEKFNVELIVQCIRVSEMPQTHHHALLLLGTVAGIFPDKVLHNIMSIFTFMGANVMRLDDTYSFQVINKTVKMVIPALIQSDGGDSAEVTRNVEDIVVKIINVFVDALPHVPEHRRLPVLVQLVDTLGAERFLWVLLVLLFEQYVTKTVLAAAYGEKDAILEADTEFWISVCCEFSVQHQIQSLMTILEYLLKLPEEKEETIPKSVSNKSEPQEEMLQVFNIDAHTSKQLRHFKFLSVSFMSQLLASNNFIRKVVESGGPQVLTGLEQRLLETVLGYINAVAQSMERNADKLTGKFWRALLSKAYDMLDKVNALLPTETFIPVIRGLLENPLPSVRRKALDLLNNKLQQKTSWKKKIIYHFLDLVPVLVAMVKHKRKTLEDQPINRQTALYTLKLLCKNFGAENPEPFVPVLHTTVKLIALGAKEEKNVLGSALLCVAEVVSTLEALAIPQLPSLMPPLLTTMRSTRELVSGEVYLLSALAALQKVVETLPHFISPYLEGVLSQVIHLEKITSEMGPASQANVRLTSLKKTLATMLSPRVLLPAINKTYKQIEKNWKNLMGPFMSVLREHIGVMRKEELASHQPQLTTFFLEALDFRTQHAENDLEEIGKTENYIIDCLVAMVVKLSEVTFRPLFFKLFDWAKTEDAPKDRLLTFYNLADCIAEKLKGLFTLFAGHLVKPFADTLNQVNISKTDEAFFDSENDPEKCCLLLQFILNCLYKIFLFDTQHFLSKERAEALMVPLVDQLENRLGGEEKFQERVTKHLIPCLAQFSVAMADDSLWKPLNYQILLKTRDSSPKVRFAALITVLALAEKLRENYIVLLPESIPFLAELMEDECEEVEHQCQKTIQQLETLLGEPLQSYF", "length": 2078, "header": "tr|A0A3Q1MF36-1|F1MDU9_BOVIN Computationally mapped isoform of HEAT repeat-containing protein 1 OS=Bos taurus OX=9913 GN=HEATR1 PE=3 SV=1 CANONICAL=F1MDU9-1" }, "locus": { "chromosome": "28", "start_pos": 9243946, "end_pos": 9193754, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081527.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081527.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069138.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069138.1" } ] } }, { "isoform_ac": "A0AAA9RTK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTK9/entry", "sequence": { "sequence": "MTSLAQQLQRLALPQSDSSLLSRDEVASLLFDPKEAATIDRDTAFAIGCTGLEELLGIDPSFEQFEAPLFSQLAKTLERSVQTKAVNKQLDENISLFLIHLSPYFLLKPAQKCLEWLIHRFHIHLYNQDSLIACVLPYHETRIFVRVIQLLKINNSKHKWFWLLPIKQSGVPLAKGTLVTHCYKDLGFMDFICSLVTKSVKVFAEYPGSSSQLRVLLTFYASTIVSALVAAETLSDNIVAKLFPYIQKGLKSSLPDYRAATYMIICQISVKVTMEDTFVNSLASQIIRTLIRIPSLIKDGLSCLIVLLQRQKPESLGKKPFPHLCNVPNLITLLHGISETYDISPLLRYMLPHLVVSMINQITGEETEEMDGQVYRRLLEAILTNISLKNNLDHLLAGLLFEEYISYSSQDKVDSDKVSLLNEQFLPLIRLLESRYPKTLDAVLEERLKEITDLKKQELFHQFISLSTSGGKYQFLADSDTSLMLSLNHPLAPVRLLAINHLKNVMTTPEESIDESFIKEAILTRLGDDSVDVVLSAVSAFEVFKQHFSSEVTVSHLLNLFQRAELSKNRGWYKVLEIAAGILVKEEILGENDQLSNQVVVHLLPFMIINSDDMESAEMKMAVYLSKSGICSLHPLLRGWKEALENVIKSTKSEELIGVANQKMIELLADNINSGNPSSMLKMVEDLIGVGEKESFSLKQKVTFHVVMAVLVSCCSSLKETHFPFATRVFSLLQKKIKKLENVITTVEISSEWHFELMMDRGIPLELWAHYVKQLKTAQRIAVEDSVLLLFSLKNFIHTLKAPKSFPKDDTWWNPEQLQEDSRDYLRLLIGLFETVLSGADAIHFRVLMKLFIKVHLEDVFQLFKFLSVLWTYGSSLSNPLNCRVTAALQTQALYVGCALLSSQKAQCEHQLASASSPVVVSLLINLGSPIKEVRRAAIHCLQVLSGVASQFHLVIDHVVPKAEEITSDATYVVQDLATLFEELQSEKKLKSHQKLSETLKNLLHCVYSCPSYVTKDLMKVLQDINNELVLSQLLSMIEQLLEKSQKEPAAVLKDEAIALHLILGKYNEYSASLLHKDPKSLDIFIKALHTTKELCMGMPAIQITALEKITKPFFAAITDEKVQQKLLCVLFDLLVNCKNSHCSQTVSSVFKGISVNAEQVRIELEPPDKAKSLGTIQQTRRQKMQHKKSQDQESVQEVGGSYWQRVTLILELLQHKKKLKNPQILIPTLFNLLSRCLEPLPPEQGSMEYTKQLILSCLLNICQKLSPEGGRIPKDVLDEEKFNVELIVQCIRVSEMPQTHHHALLLLGTVAGIFPDKVLHNIMSIFTFMGANVMRLDDTYSFQVINKTVKMVIPALIQSDGGDSAEVTRNVEDIVVKIINVFVDALPHVPEHRRLPVLVQLVDTLGAERFLWVLLVLLFEQYVTKTVLAAAYGEKDAILEADTEFWISVCCEFSVQHQIQSLMTILEYLLKLPEEKEETIPKSVSNKSEPQEEMLQVFNIDAHTSKQLRHFKFLSVSFMSQLLASNNFIRKVVESGGPQVLTGLEQRLLETVLGYINAVAQSMERNADKLTGKFWRALLSKAYDMLDKVNALLPTETFIPVIRGLLENPLPSVRRKALDLLNNKLQQKTSWKKKIIYHFLDLVPVLVAMVKHKRKTLEDQPINRQTALYTLKLLCKNFGAENPEPFVPVLHTTVKLIALGAKEEKNVLGSALLCVAEVVSTLEALAIPQLPSLMPPLLTTMRSTRELVSGEVYLLSALAALQKVVETLPHFISPYLEGVLSQNLMGPFMSVLREHIGVMRKEELASHQPQLTTFFLEALDFRTQHAENDLEEIGKTENYIIDCLVAMVVKLSEVTFRPLFFKLFDWAKTEDAPKDRLLTFYNLADCIAEKLKGLFTLFAGHLVKPFADTLNQVNISKTDEAFFDSENDPEKCCLLLQFILNCLYKIFLFDTQHFLSKERAEALMVPLVDQLENRLGGEEKFQERVTKHLIPCLAQFSVAMADDSLWKPLNYQILLKTRDSSPKVRFAALITVLALAEKLRENYIVLLPESIPFLAELMEDECEEVEHQCQKTIQQLETLLGEPLQSYF", "length": 2089, "header": "tr|A0AAA9RTK9-1|F1MDU9_BOVIN Computationally mapped isoform of HEAT repeat-containing protein 1 OS=Bos taurus OX=9913 GN=HEATR1 PE=3 SV=1 CANONICAL=F1MDU9-1" }, "locus": { "chromosome": "28", "start_pos": 9243946, "end_pos": 9193754, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128770.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128770.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075258.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075258.1" } ] } }, { "isoform_ac": "A0AAA9RYM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYM1/entry", "sequence": { "sequence": "MTSLAQQLQRLALPQSDSSLLSRDEVASLLFDPKEAATIDRDTAFAIGCTGLEELLGIDPSFEQFEAPLFSQLAKTLERSVQTKAVNKQLDENISLFLIHLSPYFLLKPAQKCLEWLIHRFHIHLYNQDSLIACVLPYHETRIFVRVIQLLKINNSKHKWFWLLPIKQSGVPLAKGTLVTHCYKDLGFMDFICSLVTKSVKVFAEYPGSSSQLRVLLTFYASTIVSALVAAETLSDNIVAKLFPYIQKGLKSSLPDYRAATYMIICQISVKVTMEDTFVNSLASQIIRTLIRIPSLIKDGLSCLIVLLQRQKPESLGKKPFPHLCNVPNLITLLHGISETYDISPLLRYMLPHLVVSMINQITGEETEEMDGQVYRRLLEAILTNISLKNNLDHLLAGLLFEEYISYSSQDKVDSDKVSLLNEQFLPLIRLLESRYPKTLDAVLEERLKEITDLKKQELFHQFISLSTSGGKYQFLADSDTSLMLSLNHPLAPVRLLAINHLKNVMTTPEESIDESFIKEAILTRLGDDSVDVVLSAVSAFEVFKQHFSSEVTVSHLLNLFQRAELSKNRGWYKVLEIAAGILVKEEILGENDQLSNQVVVHLLPFMIINSDDMESAEMKMAVYLSKSGICSLHPLLRGWKEALENVIKSTKSEELIGVANQKMIELLADNINSGNPSSMLKMVEDLIGVGEKESFSLKQKVTFHVVMAVLVSCCSSLKETHFPFATRVFSLLQKKIKKLENVITTVEISSEWHFELMMDRGIPLELWAHYVKQLKTAQRIAVEDSVLLLFSLKNFIHTLKAPKSFPKDDTWWNPEQLQEDSRDYLRLLIGLFETVLSGADAIHFRVLMKLFIKVHLEDVFQLFKFLSVLWTYGSSLSNPLNCRVTAALQTQALYVGCALLSSQKAQCEHQLASASSPVVVSLLINLGSPIKEVRRAAIHCLQVLSGVASQFHLVIDHVVPKAEEITSDATYVVQDLATLFEELQSEKKLKSHQKLSETLKNLLHCVYSCPSYVTKDLMKVLQDINNEISVNAEQVRIELEPPDKAKSLGTIQQTRRQKMQHKKSQDQESVQEVGGSYWQRVTLILELLQHKKKLKNPQILIPTLFNLLSRCLEPLPPEQGSMEYTKQLILSCLLNICQKLSPEGGRIPKDVLDEEKFNVELIVQCIRVSEMPQTHHHALLLLGTVAGIFPDKVLHNIMSIFTFMGANVMRLDDTYSFQVINKTVKMVIPALIQSDGGDSAEVTRNVEDIVVKIINVFVDALPHVPEHRRLPVLVQLVDTLGAERFLWVLLVLLFEQYVTKTVLAAAYGEKDAILEADTEFWISVCCEFSVQHQIQSLMTILEYLLKLPEEKEETIPKSVSNKSEPQEEMLQVFNIDAHTSKQLRHFKFLSVSFMSQLLASNNFIRKVVESGGPQVLTGLEQRLLETVLGYINAVAQSMERNADKLTGKFWRALLSKAYDMLDKVNALLPTETFIPVIRGLLENPLPSVRRKALDLLNNKLQQKTSWKKKIIYHFLDLVPVLVAMVKHKRKTLEDQPINRQTALYTLKLLCKNFGAENPEPFVPVLHTTVKLIALGAKEEKNVLGSALLCVAEVVSTLEALAIPQLPSLMPPLLTTMRSTRELVSGEVYLLSALAALQKVVETLPHFISPYLEGVLSQNLMGPFMSVLREHIGVMRKEELASHQPQLTTFFLEALDFRTQHAENDLEEIGKTENYIIDCLVAMVVKLSEVTFRPLFFKLFDWAKTEDAPKDRLLTFYNLADCIAEKLKGLFTLFAGHLVKPFADTLNQVNISKTDEAFFDSENDPEKCCLLLQFILNCLYKIFLFDTQHFLSKERAEALMVPLVDQLENRLGGEEKFQERVTKHLIPCLAQFSVAMADDSLWKPLNYQILLKTRDSSPKVRFAALITVLALAEKLRENYIVLLPESIPFLAELMEDECEEVEHQCQKTIQQLETLLGEPLQSYF", "length": 1964, "header": "tr|A0AAA9RYM1-1|F1MDU9_BOVIN Computationally mapped isoform of HEAT repeat-containing protein 1 OS=Bos taurus OX=9913 GN=HEATR1 PE=3 SV=1 CANONICAL=F1MDU9-1" }, "locus": { "chromosome": "28", "start_pos": 9243946, "end_pos": 9193754, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116932.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116932.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074900.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074900.1" } ] } }, { "isoform_ac": "A0AAA9SF10-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF10/entry", "sequence": { "sequence": "MTSLAQQLQRLALPQSDSSLLSRDEVASLLFDPKEAATIDRDTAFAIGCTGLEELLGIDPSFEQFEAPLFSQLAKTLERSVQTKAVNKQLDENISLFLIHLSPYFLLKPAQKCLEWLIHRFHIHLYNQDSLIACVLPYHETRIFVRVIQLLKINNSKHKWFWLLPIKQSGVPLAKGTLVTHCYKDLGFMDFICSLVTKSVKVFAEYPGSSSQLRVLLTFYASTIVSALVAAETLSDNIVAKLFPYIQKGLKSSLPDYRAATYMIICQISVKVTMEDTFVNSLASQIIRTLIRIPSLIKDGLSCLIVLLQRQKPESLGKKPFPHLCNVPNLITLLHGISETYDISPLLRYMLPHLVVSMINQITGEETEEMDGQVYRRLLEAILTNISLKNNLDHLLAGLLFEEYISYSSQDKVDSDKVSLLNEQFLPLIRLLESRYPKTLDAVLEERLKEITDLKKQELFHQFISLSTSGGKYQFLADSDTSLMLSLNHPLAPVRLLAINHLKNVMTTPEESIDESFIKEAILTRLGDDSVDVVLSAVSAFEVFKQHFSSEVTVSHLLNLFQRAELSKNRGWYKVLEIAAGILVKEEILGENDQLSNQVVVHLLPFMIINSDDMESAEMKMAVYLSKSGICSLHPLLRGWKEALENVIKSTKSEELIGVANQKMIELLADNINSGNPSSMLKMVEDLIGVGEKESFSLKQKVTFHVVMAVLVSCCSSLKETHFPFATRVFSLLQKKIKKLENVITTVEISSEWHFELMMDRGIPLELWAHYVKQLKTAQRIAVEDSVLLLFSLKNFIHTLKAPKSFPKDDTWWNPEQLQEDSRDYLRLLIGLFETVLSGADAIHFRVLMKLFIKVHLEDVFQLFKFLSVLWTYGSSLSNPLNCRVTAALQTQALYVGCALLSSQKAQCEHQLASASSPVVVSLLINLGSPIKEVRRAAIHCLQVLSGVASQFHLVIDHVVPKAEEITSDATYVVQDLATLFEELQSEKKLKSHQKLSETLKNLLHCVYSCPSYVTKDLMKVLQDINNELVLSQLLSMIEQLLEKSQKEPAAVLKDEAIALHLILGKYNEYSASLLHKDPKSLDIFIKALHTTKELCMGMPAIQITALEKITKPFFAAITDEKVQQKLLCVLFDLLVNCKNSHCSQTVSSVFKGISVNAEQVRIELEPPDKAKSLGTIQQTRRQKMQHKKSQDQESVQEVGGSYWQRVTLILELLQHKKKLKNPQILIPTLFNLLSRCLEPLPPEQGSMEYTKQLILSCLLNICQKLSPEGGRIPKDVLDEEKFNVELIVQCIRVSEMPQTHHHALLLLGTVAGIFPDKVLHNIMSIFTFMGANVMRLDDTYSFQVINKTVKMVIPALIQSDGGDSAEVTRNVEDIVVKIINVFVDALPHVPEHRRLPVLVQLVDTLGAERFLWVLLVLLFEQYVTKTVLAAAYGEKDAILEADTEFWISVCCEFSVQHQIQSLMTILEYLLKLPEEKEETIPKSVSNKSEPQEEMLQVFNIDAHTSKQLRHFKFLSVSFMSQLLASNNFIRKVVESGGPQVLTGLEQRLLETVLGYINAVAQSMERNADKLTGKFWRALLSKAYDMLDKVNALLPTETFIPVIRGLLENPLPSVRRKALDLLNNKLQQKTSWKKKIIYHFLDLVPVLVAMVKHKRKTLEDQPINRQTALYTLKLLCKNFGAENPEPFVPVLHTTVKLIALGAKEEKNVLGSALLCVAEVVSTLEALAIPQLPSLMPPLLTTMRSTRELVSGEVYLLSALAALQKVVETLPHFISPYLEGVLSQVIHLEKITSEMGPASQANVRLTSLKKTLATMLSPRVLLPAINKTYKQIEKNWKNLMGPFMSVLREHIGVMRKEELASHQPQLTTFFLEALDFRTQHAENDLEEIGKTENYIIDCLVAMVVKLSEVTFRPLFFKLFDWAKTEDAPKDRLLTFYNLADCIAEKLKGLFTLFAGHLVKPFADTLNQVNISKTDEAFFDSENDPEKCCLLLQFILNCLYKIFLFDTQHFLSKERAEALMVPLVDQLENRLGGEEKFQERVTKHLIPCLAQFSVAMADDSLWKPLNYQILLKTRDSSPKVRRSGAAWMLCAWHPWPRPQDLHCCV", "length": 2103, "header": "tr|A0AAA9SF10-1|F1MDU9_BOVIN Computationally mapped isoform of HEAT repeat-containing protein 1 OS=Bos taurus OX=9913 GN=HEATR1 PE=3 SV=1 CANONICAL=F1MDU9-1" }, "locus": { "chromosome": "28", "start_pos": 9243946, "end_pos": 9196240, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089481.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089481.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084747.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084747.1" } ] } }, { "isoform_ac": "A0AAA9SR68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR68/entry", "sequence": { "sequence": "MTSLAQQLQRLALPQSDSSLLSRDEVASLLFDPKEAATIDRDTAFAIGCTGLEELLGIDPSFEQFEAPLFSQLAKTLERSVQTKAVNKQLDENISLFLIHLSPYFLLKPAQKCLEWLIHRFHIHLYNQDSLIACVLPYHETRIFVRVIQLLKINNSKHKWFWLLPIKQSGVPLAKGTLVTHCYKDLGFMDFICSLVTKSVKVFAEYPGSSSQLRVLLTFYASTIVSALVAAETLSDNIVAKLFPYIQKGLKSSLPDYRAATYMIICQISVKVTMEDTFVNSLASQIIRTLIRIPSLIKDGLSCLIVLLQRQKPESLGKKPFPHLCNVPNLITLLHGISETYDISPLLRYMLPHLVVSMINQITGEETEEMDGQVYRRLLEAILTNISLKNNLDHLLAGLLFEEYISYSSQDKVDSDKVSLLNEQFLPLIRLLESRYPKTLDAVLEERLKEITDLKKQELFHQFISLSTSGGKYQFLADSDTSLMLSLNHPLAPVRLLAINHLKNVMTTPEESIDESFIKEAILTRLGDDSVDVVLSAVSAFEVFKQHFSSEVTVSHLLNLFQRAELSKNRGWYKVLEIAAGILVKEEILGENDQLSNQVVVHLLPFMIINSDDMESAEMKMAVYLSKSGICSLHPLLRGWKEALENVIKSTKSEELIGVANQKMIELLADNINSGNPSSMLKMVEDLIGVGEKESFSLKQKVTFHVVMAVLVSCCSSLKETHFPFATRVFSLLQKKIKKLENVITTVEISSEWHFELMMDRGIPLELWAHYVKQLKTAQRIAVEDSVLLLFSLKNFIHTLKAPKSFPKDDTWWNPEQLQEDSRDYLRLLIGLFETVLSGADAIHFRVLMKLFIKVHLEDVFQLFKFLSVLWTYGSSLSNPLNCRVTAALQTQALYVGCALLSSQKAQCEHQLASASSPVVVSLLINLGSPIKEVRRAAIHCLQVLSGVASQFHLVIDHVVPKAEEITSDATYVVQDLATLFEELQSEKKLKSHQKLSETLKNLLHCVYSCPSYVTKDLMKVLQDINNEITKPFFAAITDEKVQQKLLCVLFDLLVNCKNSHCSQTVSSVFKGISVNAEQVRIELEPPDKAKSLGTIQQTRRQKMQHKKSQDQESVQEVGGSYWQRVTLILELLQHKKKLKNPQILIPTLFNLLSRCLEPLPPEQGSMEYTKQLILSCLLNICQKLSPEGGRIPKDVLDEEKFNVELIVQCIRVSEMPQTHHHALLLLGTVAGIFPDKVLHNIMSIFTFMGANVMRLDDTYSFQVINKTVKMVIPALIQSDGGDSAEVTRNVEDIVVKIINVFVDALPHVPEHRRLPVLVQLVDTLGAERFLWVLLVLLFEQYVTKTVLAAAYGEKDAILEADTEFWISVCCEFSVQHQIQSLMTILEYLLKLPEEKEETIPKSVSNKSEPQEEMLQVFNIDAHTSKQLRHFKFLSVSFMSQLLASNNFIRKVVESGGPQVLTGLEQRLLETVLGYINAVAQSMERNADKLTGKFWRALLSKAYDMLDKVNALLPTETFIPVIRGLLENPLPSVRRKALDLLNNKLQQKTSWKKKIIYHFLDLVPVLVAMVKHKRKTLEDQPINRQTALYTLKLLCKNFGAENPEPFVPVLHTTVKLIALGAKEEKNVLGSALLCVAEVVSTLEALAIPQLPSLMPPLLTTMRSTRELVSGEVYLLSALAALQKVVETLPHFISPYLEGVLSQVIHLEKITSEMGPASQANVRLTSLKKTLATMLSPRVLLPAINKTYKQIEKNWKNLMGPFMSVLREHIGVMRKEELASHQPQLTTFFLEALDFRTQHAENDLEEIGKTENYIIDCLVAMVVKLSEVTFRPLFFKLFDWAKTEDAPKDRLLTFYNLADCIAEKLKGLFTLFAGHLVKPFADTLNQVNISKTDEAFFDSENDPEKCCLLLQFILNCLYKIFLFDTQHFLSKERAEALMVPLVDQLENRLGGEEKFQERVTKHLIPCLAQFSVAMADDSLWKPLNYQILLKTRDSSPKVRFAALITVLALAEKLRENYIVLLPESIPFLAELMEDECEEVEHQCQKTIQQLETLLGEPLQSYF", "length": 2061, "header": "tr|A0AAA9SR68-1|F1MDU9_BOVIN Computationally mapped isoform of HEAT repeat-containing protein 1 OS=Bos taurus OX=9913 GN=HEATR1 PE=3 SV=1 CANONICAL=F1MDU9-1" }, "locus": { "chromosome": "28", "start_pos": 9243946, "end_pos": 9193754, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135963.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135963.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086473.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086473.1" } ] } }, { "isoform_ac": "F1MDU9-1", "url": "https://www.uniprot.org/uniprotkb/F1MDU9/entry", "sequence": { "sequence": "MTSLAQQLQRLALPQSDSSLLSRDEVASLLFDPKEAATIDRDTAFAIVFLGCTGLEELLGIDPSFEQFEAPLFSQLAKTLERSVQTKAVNKQLDENISLFLIHLSPYFLLKPAQKCLEWLIHRFHIHLYNQDSLIACVLPYHETRIFVRVIQLLKINNSKHKWFWLLPIKQSGVPLAKGTLVTHCYKDLGFMDFICSLVTKSVKVFAEYPGSSSQLRVLLTFYASTIVSALVAAETLSDNIVAKLFPYIQKGLKSSLPDYRAATYMIICQISVKVTMEDTFVNSLASQIIRTLIRIPSLIKDGLSCLIVLLQRQKPESLGKKPFPHLCNVPNLITLLHGISETYDISPLLRYMLPHLVVSMINQITGEETEEMDGQVYRRLLEAILTNISLKNNLDHLLAGLLFEEYISYSSQDKVDSDKVSLLNEQFLPLIRLLESRYPKTLDAVLEERLKEITDLKKQELFHQFISLSTSGGKYQFLADSDTSLMLSLNHPLAPVRLLAINHLKNVMTTPEESIDESFIKEAILTRLGDDSVDVVLSAVSAFEVFKQHFSSEVTVSHLLNLFQRAELSKNRGWYKVLEIAAGILVKEEILGENDQLSNQVVVHLLPFMIINSDDMESAEMKMAVYLSKSGICSLHPLLRGWKEALENVIKSTKSEELIGVANQKMIELLADNINSGNPSSMLKMVEDLIGVGEKESFSLKQKVTFHVVMAVLVSCCSSLKETHFPFATRVFSLLQKKIKKLENVITTVEISSEWHFELMMDRGIPLELWAHYVKQLKTAQRIAVEDSVLLLFSLKNFIHTLKAPKSFPKDDTWWNPEQLQEDSRDYLRLLIGLFETVLSGADAIHFRVLMKLFIKVHLEDVFQLFKFLSVLWTYGSSLSNPLNCRVTAALQTQALYVGCALLSSQKAQCEHQLASASSPVVVSLLINLGSPIKEVRRAAIHCLQVLSGVASQFHLVIDHVVPKAEEITSDATYVVQDLATLFEELQSEKKLKSHQKLSETLKNLLHCVYSCPSYVTKDLMKVLQDINNELVLSQLLSMIEQLLEKSQKEPAAVLKDEAIALHLILGKYNEYSASLLHKDPKSLDIFIKALHTTKELCMGMPAIQITALEKITKPFFAAITDEKVQQKLLCVLFDLLVNCKNSHCSQTVSSVFKGISVNAEQVRIELEPPDKAKSLGTIQQTRRQKMQHKKSQDQESVQEVGGSYWQRVTLILELLQHKKKLKNPQILIPTLFNLLSRCLEPLPPEQGSMEYTKQLILSCLLNICQKLSPEGGRIPKDVLDEEKFNVELIVQCIRVSEMPQTHHHALLLLGTVAGIFPDKVLHNIMSIFTFMGANVMRLDDTYSFQVINKTVKMVIPALIQSDGGDSAEVTRNVEDIVVKIINVFVDALPHVPEHRRLPVLVQLVDTLGAERFLWVLLVLLFEQYVTKTVLAAAYGEKDAILEADTEFWISVCCEFSVQHQIQSLMTILEYLLKLPEEKEETIPKSVSNKSEPQEEMLQVFNIDAHTSKQLRHFKFLSVSFMSQLLASNNFIRKVVESGGPQVLTGLEQRLLETVLGYINAVAQSMERNADKLTGKFWRALLSKAYDMLDKVNALLPTETFIPVIRGLLENPLPSVRRKALDLLNNKLQQKTSWKKKIIYHFLDLVPVLVAMVKHKRKTLEDQPINRQTALYTLKLLCKNFGAENPEPFVPVLHTTVKLIALGAKEEKNVLGSALLCVAEVVSTLEALAIPQLPSLMPPLLTTMRSTRELVSGEVYLLSALAALQKVVETLPHFISPYLEGVLSQVIHLEKITSEMGPASQANVRLTSLKKTLATMLSPRVLLPAINKTYKQIEKNWKNLMGPFMSVLREHIGVMRKEELASHQPQLTTFFLEALDFRTQHAENDLEEIGKTENYIIDCLVAMVVKLSEVTFRPLFFKLFDWAKTEDAPKDRLLTFYNLADCIAEKLKGLFTLFAGHLVKPFADTLNQVNISKTDEAFFDSENDPEKCCLLLQFILNCLYKIFLFDTQHFLSKERAEALMVPLVDQLENRLGGEEKFQERVTKHLIPCLAQFSVAMADDSLWKPLNYQILLKTRDSSPKVRFAALITVLALAEKLRENYIVLLPESIPFLAELMEDECEEVEHQCQKTIQQLETLLGEPLQSYF", "length": 2145, "header": "tr|F1MDU9-1|F1MDU9_BOVIN Isoform 1 of HEAT repeat-containing protein 1 OS=Bos taurus OX=9913 GN=HEATR1 PE=3 SV=4 CANONICAL=F1MDU9-1" }, "locus": { "chromosome": "28", "start_pos": 9243946, "end_pos": 9193754, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061542.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061542.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053851.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053851.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "pmid": "" }, { "name": "t-UTP complex", "id": "GO:0034455", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034455", "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "pmid": "" }, { "name": "90S preribosome", "id": "GO:0030686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030686", "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "pmid": "" }, { "name": "positive regulation of rRNA processing", "id": "GO:2000234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000234", "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "pmid": "" }, { "name": "protein localization to nucleolus", "id": "GO:1902570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902570", "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase I", "id": "GO:0045943", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045943", "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "pmid": "" }, { "name": "neural precursor cell proliferation", "id": "GO:0061351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061351", "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "pmid": "" }, { "name": "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000462", "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "snoRNA binding", "id": "GO:0030515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030515", "evidence": [ { "database": "UniProtKB", "id": "F1MDU9", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1350, "end_pos": 1352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1490, "end_pos": 1492, "annotation": "n_glycosylation_sequon" }, { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1828, "end_pos": 1830, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1971, "end_pos": 1973, "annotation": "n_glycosylation_sequon" }, { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MDU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDU9" }, { "id": "SM01036", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01036" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BP28 C-terminal", "eco_id": "ECO_0000259", "start_pos": 1858, "end_pos": 2011, "start_aa": "Lys", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1350, "end_pos": 1352 }, { "start_pos": 1490, "end_pos": 1492 }, { "start_pos": 157, "end_pos": 159 }, { "start_pos": 1828, "end_pos": 1830 }, { "start_pos": 1971, "end_pos": 1973 }, { "start_pos": 388, "end_pos": 390 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MBE8-1", "uniprot_ac": "F1MBE8", "uniprot_id": "F1MBE8_BOVIN", "mass": { "chemical_mass": 106251.0, "monoisotopic_mass": 106251.0 }, "refseq": {}, "gene_names": [ { "name": "CASD1", "type": "recommended", "evidence": [ { "id": "F1MBE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBE8" } ] } ], "protein_names": [ { "name": "N-acetylneuraminate (7)9-O-acetyltransferase", "type": "recommended", "evidence": [ { "id": "F1MBE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBE8/entry#names_and_taxonomy" } ] }, { "name": "2.3.1.45", "type": "synonym", "evidence": [ { "id": "F1MBE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBE8/entry#names_and_taxonomy" } ] }, { "name": "CAS1 domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "F1MBE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBE8/entry#names_and_taxonomy" } ] }, { "name": "CAS1 protein", "type": "synonym", "evidence": [ { "id": "F1MBE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBE8/entry#names_and_taxonomy" } ] }, { "name": "Sialate O-acetyltransferase", "type": "synonym", "evidence": [ { "id": "F1MBE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBE8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MBE8", "url": "https://www.uniprot.org/uniprotkb/F1MBE8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CASD1", "url": "https://www.uniprot.org/uniprotkb/F1MBE8", "locus": { "chromosome": "4", "start_pos": 11940855, "end_pos": 11886874, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009109", "url": "https://www.ensembl.org/id/ENSBTAG00000009109" } ] } } ], "crossref": [ { "id": "F1MBE8", "url": "https://alphafold.ebi.ac.uk/entry/F1MBE8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009109", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009109", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532541", "url": "https://www.ncbi.nlm.nih.gov/gene/532541", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012419", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012419", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532541", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532541", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WSAREWA", "url": "https://omabrowser.org/oma/group/WSAREWA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MB17", "url": "https://www.orthodb.org/?gene=A0A3Q1MB17", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MHF1", "url": "https://www.orthodb.org/?gene=A0A3Q1MHF1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MQQ4", "url": "https://www.orthodb.org/?gene=A0A3Q1MQQ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MBE8", "url": "https://www.orthodb.org/?gene=F1MBE8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13533", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13533", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13533:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13533:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07779", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07779", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "79499", "url": "https://www.rhea-db.org/rhea/79499", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "79555", "url": "https://www.rhea-db.org/rhea/79555", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "81827", "url": "https://www.rhea-db.org/rhea/81827", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MB17", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MB17-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MHF1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQQ4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBE8", "url": "https://www.uniprot.org/uniprotkb/F1MBE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBE8-1", "url": "https://www.uniprot.org/uniprotkb/F1MBE8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLPPPPPPAAGDPVTPEDSLGSVTPEDWATGPPLQAQPLLRQEAKGKEEEGEETGVQGAWGKGTAEQRRRGWGEAAEAAAAEEGQVDAGGAAGSASPAGAAGGGREGWRRLLAWLRRRQPQCCPCAAPLPRSAAHCCHGGTKMAALAYNLGKREINHYFSVRSAKVLALVAVLLLAVCHLASRRYRGNDSCEYLLSSGRFLGEKVWQPHSCMMHKYKISEAKNCLVDKHIAFIGDSRIRQLFYSFVKIINPQFKEEGNKHENIPFEDKIASVKVDFLWHPEVNGSMKQCIKVWTEDSVAKPHVIVAGAATWSIKIHNGSNEALSQYKMNITSIAPLLEKLAKTSDVYWVLQDPVYEDLLSENRKMITNEKIDAYNEAAVSILNSSTRNSKSHVKVFSVSKLIAQETIMESLDGLHLPESSRETSAMILMNVYCNKILKPVDGSCCQPRPPLTLIQKLAACFFTLSIVGYLIFYIIHRNAHRKNKPCTDLESGEEKKNIINPPVSPLEIFLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSTFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWVKGDFGIHRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYVTLALWPQITQKKANGNCLWHFGLLLKLAFLLLCICFLAYSQGAFEKIFSLWPLSKCFELKGNVYEWWFRWRLDRYVVFHGMLFAFIYLALQKRQILSEGKGEPLFSSKISNFLLFISVVSFLTYSIWASSCKNKAQCNELHPSVSVVQILAFILIRNIPGYARSVYSSFFAWFGKISLELFICQYHIWLAADTRGILVLIPGNPMLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSSLLKRLACIAAFFCGLLILSSIQDKSRH", "length": 940, "header": "tr|F1MBE8-1|F1MBE8_BOVIN Isoform 1 of N-acetylneuraminate (7)9-O-acetyltransferase OS=Bos taurus OX=9913 GN=CASD1 PE=3 SV=3 CANONICAL=F1MBE8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MB17-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB17/entry", "sequence": { "sequence": "MSLPPPPPPAAGDPVTPEDSLGSVTPEDWATGPPLQAQPLLRQEAKGKEEEGEETGVQGAWGKGTAEQRRRGWGEAAEAAAAEEGQVDAGGAAGSASPAGAAGGGREGWRRLLAWLRRRQPQCCPCAAPLPRSAAHCCHGGTKMAALAYNLGKREINHYFSVRSAKVLALVAVLLLAVCHLASRRYRGNDSCEYLLSSGRFLGEKVWQPHSCMMHKYKISEAKNCLVDKHIAFIGDSRIRQLFYSFVKIINPQFKEEGNKHENIPFEDKIASVKVDFLWHPEVNGSMKQCIKVWTEDSVAKPHVIVAGAATWSIKIHNGSNEALSQYKMNITSIAPLLEKLAKTSDVYWVLQDPVYEDLLSENRKMITNEKIDAYNEAAVSILNSSTRNSKSHVKVFSVSKLIAQETIMESLDGLHLPESSRETSAMILMNVYCNKILKPVDGSCCQPRPPLTLIQKLAACFFTLSIVGYLIFYIIHRNAHRKNKPCTDLESGEEKKNIINPPVSPLEIFLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSTFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWVKGDFGIHRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYVTLALWPQITQKKANGNCLWHFGLLLKLAFLLLCICFLAYSQTSLMFRNVPKTSAPSFPDFPDCQINKKGAFEKIFSLWPLSKCFELKGNVYEWWFRWRLDRYVVFHGMLFAFIYLALQKRQILSEGKGEPLFSSKISNFLLFISVVSFLTYSIWASSCKNKAQCNELHPSVSVVQILAFILIRNIPGYARSVYSSFFAWFGKISLELFICQYHIWLAADTRGILVLIPGNPMLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSSLLKRLACIAAFFCGLLILSSIQDKSRH", "length": 967, "header": "tr|A0A3Q1MB17-1|F1MBE8_BOVIN Computationally mapped isoform of N-acetylneuraminate (7)9-O-acetyltransferase OS=Bos taurus OX=9913 GN=CASD1 PE=3 SV=1 CANONICAL=F1MBE8-1" }, "locus": { "chromosome": "4", "start_pos": 11939851, "end_pos": 11887073, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072123.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072123.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067453.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067453.1" } ] } }, { "isoform_ac": "A0A3Q1MHF1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHF1/entry", "sequence": { "sequence": "MSLPPPPPPAAGDPVTPEDSLGSVTPEDWATGPPLQAQPLLRQEAKGKEEEGEETGVQGAWGKGTAEQRRRGWGEAAEAAAAEEGQVDAGGAAGSASPAGAAGGGREGWRRLLAWLRRRQPQCCPCAAPLPRSAAHCCHGGTKMAALAYNLGKREINHYFSVRSAKVLALVAVLLLAVCHLASRRYRGNDSCEYLLSSGRFLGEKVWQPHSCMMHKYKISEAKNCLVDKHIAFIGDSRIRQLFYSFVKIINPQFKEEGNKDSVAKPHVIVAGAATWSIKIHNGSNEALSQYKMNITSIAPLLEKLAKTSDVYWVLQDPVYEDLLSENRKMITNEKIDAYNEAAVSILNSSTRNSKSHVKVFSVSKLIAQETIMESLDGLHLPESSRETSAMILMNVYCNKILKPVDGSCCQPRPPLTLIQKLAACFFTLSIVGYLIFYIIHRNAHRKNKPCTDLESGEEKKNIINPPVSPLEIFLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSTFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWVKGDFGIHRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYVTLALWPQITQKKANGNCLWHFGLLLKLAFLLLCICFLAYSQGAFEKIFSLWPLSKCFELKGNVYEWWFRWRLDRYVVFHGMLFAFIYLALQKRQILSEGKGEPLFSSKISNFLLFISVVSFLTYSIWASSCKNKAQCNELHPSVSVVQILAFILIRNIPGYARSVYSSFFAWFGKISLELFICQYHIWLAADTRGILVLIPGNPMLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSSLLKRLACIAAFFCGLLILSSIQDKSRH", "length": 904, "header": "tr|A0A3Q1MHF1-1|F1MBE8_BOVIN Computationally mapped isoform of N-acetylneuraminate (7)9-O-acetyltransferase OS=Bos taurus OX=9913 GN=CASD1 PE=3 SV=2 CANONICAL=F1MBE8-1" }, "locus": { "chromosome": "4", "start_pos": 11939851, "end_pos": 11887073, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074342.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074342.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070669.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070669.2" } ] } }, { "isoform_ac": "A0A3Q1MQQ4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQQ4/entry", "sequence": { "sequence": "MSLPPPPPPAAGDPVTPEDSLGSVTPEDWATGPPLQAQPLLRQEAKGKEEEGEETGVQGAWGKGTAEQRRRGWGEAAEAAAAEEGQVDAGGAAGSASPAGAAGGGREGWRRLLAWLRRRQPQCCPCAAPLPRSAAHCCHGGTKMAALAYNLGKREINHYFSVRSAKVLALVAVLLLAVCHLASRRYRGNDSCEYLLSSGRFLGEKVWQPHSCMMHKYKISEAKNCLVDKHIAFIGDSRIRQLFYSFVKIINPQFKEEGNKHENIPFEDKIASVKVDFLWHPEVNGSMKQCIKVWTEDSVAKPHVIVAGAATWSIKIHNGSNEALSQYKMNITSIAPLLEKLAKTSDVYWVLQDPVYEDLLSENRKMITNEKIDAYNEAAVSILNSSTRNSKSHVKVFSVSKLIAQETIMESLDGLHLPESSRETSAMILMNVYCNKILKPVDGSCCQPRPPLTLIQKLAACFFTLSIVGYLIFYIIHRNAHRKNKPCTDLESGEEKKNIINPPVSPLEIFLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSTFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWVKGDFGIHRVCQGAFEKIFSLWPLSKCFELKGNVYEWWFRWRLDRYVVFHGMLFAFIYLALQKRQILSEGKGEPLFSSKISNFLLFISVVSFLTYSIWASSCKNKAQCNELHPSVSVVQILAFILIRNIPGYARSVYSSFFAWFGKISLELFICQYHIWLAADTRGILVLIPGNPMLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSSLLKRLACIAAFFCGLLILSSIQDKSRH", "length": 861, "header": "tr|A0A3Q1MQQ4-1|F1MBE8_BOVIN Computationally mapped isoform of N-acetylneuraminate (7)9-O-acetyltransferase OS=Bos taurus OX=9913 GN=CASD1 PE=3 SV=1 CANONICAL=F1MBE8-1" }, "locus": { "chromosome": "4", "start_pos": 11939851, "end_pos": 11887073, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070226.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070226.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074365.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074365.1" } ] } }, { "isoform_ac": "A0AAA9STK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STK8/entry", "sequence": { "sequence": "MAALAYNLGKREINHYFSVRSAKVLALVAVLLLAVCHLASRRYRGNDSCEYLLSSGRFLGEKVWQPHSCMMHKYKISEAKNCLVDKHIAFIGDSRIRQLFYSFVKIINPQFKEEGNKHENIPFEDKIASVKVDFLWHPEVNGSMKQCIKVWTEDSVAKPHVIVAGAATWSIKIHNGSNEALSQYKMNITSIAPLLEKLAKTSDVYWVLQDPVYEDLLSENRKMITNEKIDAYNEAAVSILNSSTRNSKSHVKVFSVSKLIAQETIMESLDGLHLPESSRETSAMILMNVYCNKILKPVDGSCCQPRPPLTLIQKLAACFFTLSIVGYLIFYIIHRNAHRKNKPCTDLESGEEKKNIINPPVSPLEIFLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSTFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWVKGDFGIHRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYVTLALWPQITQKKANGNCLWHFGLLLKLAFLLLCICFLAYSQGAFEKIFSLWPLSKCFELKGNVYEWWFRWRLDRYVVFHGMLFAFIYLALQKRQILSEGKGEPLFSSKISNFLLFISVVSFLTYSIWASSCKNKAQCNELHPSVSVVQLFICQYHIWLAADTRGILVLIPGNPMLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSSLLKRLACIAAFFCGLLILSSIQDKSRH", "length": 766, "header": "tr|A0AAA9STK8-1|F1MBE8_BOVIN Computationally mapped isoform of N-acetylneuraminate (7)9-O-acetyltransferase OS=Bos taurus OX=9913 GN=CASD1 PE=3 SV=1 CANONICAL=F1MBE8-1" }, "locus": { "chromosome": "4", "start_pos": 11939851, "end_pos": 11887502, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102397.2", "url": "https://www.ensembl.org/id/ENSBTAT00000102397.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088685.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088685.1" } ] } }, { "isoform_ac": "F1MBE8-1", "url": "https://www.uniprot.org/uniprotkb/F1MBE8/entry", "sequence": { "sequence": "MSLPPPPPPAAGDPVTPEDSLGSVTPEDWATGPPLQAQPLLRQEAKGKEEEGEETGVQGAWGKGTAEQRRRGWGEAAEAAAAEEGQVDAGGAAGSASPAGAAGGGREGWRRLLAWLRRRQPQCCPCAAPLPRSAAHCCHGGTKMAALAYNLGKREINHYFSVRSAKVLALVAVLLLAVCHLASRRYRGNDSCEYLLSSGRFLGEKVWQPHSCMMHKYKISEAKNCLVDKHIAFIGDSRIRQLFYSFVKIINPQFKEEGNKHENIPFEDKIASVKVDFLWHPEVNGSMKQCIKVWTEDSVAKPHVIVAGAATWSIKIHNGSNEALSQYKMNITSIAPLLEKLAKTSDVYWVLQDPVYEDLLSENRKMITNEKIDAYNEAAVSILNSSTRNSKSHVKVFSVSKLIAQETIMESLDGLHLPESSRETSAMILMNVYCNKILKPVDGSCCQPRPPLTLIQKLAACFFTLSIVGYLIFYIIHRNAHRKNKPCTDLESGEEKKNIINPPVSPLEIFLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSTFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWVKGDFGIHRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYVTLALWPQITQKKANGNCLWHFGLLLKLAFLLLCICFLAYSQGAFEKIFSLWPLSKCFELKGNVYEWWFRWRLDRYVVFHGMLFAFIYLALQKRQILSEGKGEPLFSSKISNFLLFISVVSFLTYSIWASSCKNKAQCNELHPSVSVVQILAFILIRNIPGYARSVYSSFFAWFGKISLELFICQYHIWLAADTRGILVLIPGNPMLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSSLLKRLACIAAFFCGLLILSSIQDKSRH", "length": 940, "header": "tr|F1MBE8-1|F1MBE8_BOVIN Isoform 1 of N-acetylneuraminate (7)9-O-acetyltransferase OS=Bos taurus OX=9913 GN=CASD1 PE=3 SV=3 CANONICAL=F1MBE8-1" }, "locus": { "chromosome": "4", "start_pos": 11939851, "end_pos": 11887073, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012005.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012005.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012005.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012005.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:532541", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532541", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XJ16-1", "protein_name": "N-acetylneuraminate (7)9-O-acetyltransferase", "gene_name": "CASD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGLAYTLGKREINYYFSVRSAKALALAAVLLLAACHAASRRYRGDDTCEYLLSSGRFLGEKVWQPHSCMMHKYKNSEAKSCLIDKHIVFLGDSRIRQLFYSFIKIINPQIKEEGNKHGNIPFEDKSASIKVDFLWYPEVNGSMRQRIKSWTEGSVAKPHIIVAGAATWSIKIHNGSNEALTQYKINITSIAPLLEKLAKSSDVYWILQDPVYEDMLSESRKMITNEKIDAYNEAAVRILNSSSRNSKAKVKVFSVSKLIAQETIMKSSDGLHLPESSRDMNAMILMNVYCNKIMKPIDGSCCQPQPPLTLIQKLAFCFFTLSIIGYFVISLIHRNNYRKNKSCTDLEIGEEKKPTINTPSVSTLEMLLHCFCKLGLIMTYFYLCDRANLFMKENKFYTHSSFFIPIVYILVLGVFYTENTKETKVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWIKGDFGVYRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMIIYATLAMWPQIVQKKANGNCLWHFGLLLKLICLLACIYFLSYSQGAFEKVFSFWPLSKCFELNGNVYEWWFRWKLDRYVVFHGMLFAFIYLALQKHQMISEGKGDPLFSSRVSNVLLFISIVSFLTYSIWASSCKNKAECNELHPSVSVVQILAFILIRNIPGYVRSVYSSFFAWFGKISLELFICQYHIWLAADTKGILVLIPGYPMFNVIVSTFIFVCVAHEISQITNDLAQIVVPKDNSTLLKRLLCIAGFFSGLLFFSAMQEQSRH", "length": 798 }, "evidence": [ { "id": "F1MBE8", "url": "https://omabrowser.org/oma/group/F1MBE8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "M0R6Q0-1", "protein_name": "N-acetylneuraminate (7)9-O-acetyltransferase", "gene_name": "Casd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPVQPSPSAAACDPVTPEARLGPVTPEPRASGPPSQAQPLLRQEATREEEGEETGGQGAWGTGTAEQRRRGLGEADVGTGKAGGTEAAGSGSSADGAGDGQGSWRLLLGWLLRRPPQCCPCAAPLPRSAAHCCHGGTKMAALAYNLGKREINHYFSVRSAKVLALVAVLLLAACHLASRHYRGNDSCEFLLSSGRFLGEKVWQPHSCMMHKYKISEAKTCLVDKHIAFIGDSRIRQLFYSFVKIINPQFKEEGNKHENIPFEDKVASLKVDFLWHPEVNGSMKQCIKLWTEDVVSKPHVIVAGAATWSIKIHNGSEEALSQYKMNITSIAPLLEKLAKTSDVYWVLQDPVYEDLLSENRKMITNEKIDAYNEAAVSILNSSTRTSKSNVKMFSVSKLIAQETIMESLDGLHLPESSRETSAMILMNVYCNKILKPVDGSCCQPRPPLTLIQKLAACFFTLSIIGYLIFYVIHRNAHRKNKPCPDLESGEEKKNIINTPVSSLEILLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWIKGDFGIHRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYITLALWPQVTQKKANGNGFWYLGLLLKLAFLLLCICFLAYSQGAFEKIFSLWPLSKCFELEGSVYEWWFRWRLDRYVVLHGALFAFIYLALQRRQILSEGKGEPLFSNKISNFLLFVSVVSFLTYSIWASSCKNKAECNELHPSVSVVQIVAFILIRNTPGYARSIYSSFFAWFGKISLELFICQYHIWLAADTRGILVLIPGNPTLNIAVSTFIFVCVAHEISQITADLAHVVIPKDNPALFRRLACTLAFFAGLLVLSSIQDKSRL", "length": 935 }, "evidence": [ { "id": "F1MBE8", "url": "https://omabrowser.org/oma/group/F1MBE8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TN73-1", "protein_name": "N-acetylneuraminate (7)9-O-acetyltransferase", "gene_name": "Casd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAALAYNLGKREINHYFSVRSAKVLALVAVLLLAACHLASRRYRGNDSCEYLLSSGRFLGEKVWQPHSCMMHKYKISEAKTCLVDKHIAFIGDSRIRQLFYSFVKIINPQFKEEGNKHENIPFEDKAASVKVDFLWHPEVNGSMKQCIKVWTEDSVLKPHVIVAGAATWSIKIHNGSEEALAQYKMNITSIAPLLEKLAKTSDVYWVLQDPVYEDLLSENRKMITNEKIDAYNEAAVSILNSSTRTSKSNVKMFSVSKLIAQETIMESLDGLHLPESSRETSAMILMNVYCNKVVKPVDGSCCQPRPPLTLIQKLAACFFTLSIIGYFIFYVIHRNAHRKNKPCTDLESGEEKKNIINTPVSSLEILLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWIKGDFGIHRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYVTLALWPQITQKKANGNFFWYLGLLLKLGLLLLCIWFLAYSQGAFEKIFSLWPLSKCFELEGSVYEWWFRWRLDRYVVFHGVLFAFIYLALQRRQILSEGKGEPLFSNKISNFLLFVSVVSFLTYSIWASSCKNKAECNELHPSVSVVQIVAFILIRNIPGYARSIYSSFFAWFGKISLELFICQYHIWLAADTRGILVLIPGNPTLNIIVSTFIFVCVAHEISQITTDLAQVVIPKDNPSLFRRLACTIAFFGGVLILSSIQDKSRL", "length": 797 }, "evidence": [ { "id": "F1MBE8", "url": "https://omabrowser.org/oma/group/F1MBE8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96PB1-1", "protein_name": "N-acetylneuraminate (7)9-O-acetyltransferase", "gene_name": "CASD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALAYNLGKREINHYFSVRSAKVLALVAVLLLAACHLASRRYRGNDSCEYLLSSGRFLGEKVWQPHSCMMHKYKISEAKNCLVDKHIAFIGDSRIRQLFYSFVKIINPQFKEEGNKHENIPFEDKTASVKVDFLWHPEVNGSMKQCIKVWTEDSIAKPHVIVAGAATWSIKIHNGSSEALSQYKMNITSIAPLLEKLAKTSDVYWVLQDPVYEDLLSENRKMITNEKIDAYNEAAVSILNSSTRNSKSNVKMFSVSKLIAQETIMESLDGLHLPESSRETTAMILMNVYCNKILKPVDGSCCQPRPPVTLIQKLAACFFTLSIIGYLIFYIIHRNAHRKNKPCTDLESGEEKKNIINTPVSSLEILLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFYNENTKETKVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWIKGDFGIYRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYVTLALWPQIIQKKANGNCFWHFGLLLKLGFLLLFICFLAYSQGAFEKIFSLWPLSKCFELKGNVYEWWFRWRLDRYVVFHGMLFAFIYLALQKRQILSEGKGEPLFSNKISNFLLFISVVSFLTYSIWASSCKNKAECNELHPSVSVVQILAFILIRNIPGYARSVYSSFFAWFGKISLELFICQYHIWLAADTRGILVLIPGNPMLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSSLLKRLACIAAFFCGLLILSSIQDKSKH", "length": 797 }, "evidence": [ { "id": "F1MBE8", "url": "https://omabrowser.org/oma/group/F1MBE8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W4P0-1", "protein_name": "Cas1p 10 TM acyl transferase domain-containing protein", "gene_name": "Dmel\\CG2938", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MELRELRGGNGGSVGGIGAATTGTPGVSVNGAPSPELGGICIGGAAGGQRMPTRADIFMEQLNATNAKKVALLLVLGFIVYHGLLNWKYGSDSCQWLLSKGRFKGDNEWQPYGCMVHKYSLTDTRRCLRYLAFFDNKNNFVFIGDESIRLLYERFVEQLRLPLAADEMADEEDNNASVTDGSARFEDKKLHMLAQYIRAEEVSPSLVEQLYRLESEKQLSSVYVVGFTYAGLLAGNTTDDVLRQYAANLTLLVAPFHRLVAQTSRVLWKLADRVDEEKLPAHWKLLQNEQIDRLNHVARGVFRYTEASVWESAWHIANGLLDNAIDGHQLCAHGQRLEVQLLWNMYCNDYMNYNDGTCCSSSEPYTTLQIVAYALFGVCMALVCGMCLRRWVLHLRGQTLYVPLQQQQSYDGGRAGGGSPSNALSALITDYGTPMVALSLLGLILAYFYLCDRTNFFMKENKYYSEFSFWIPVGYVFALGLFFTEDSRFTKVLNRDQTDELRGWILLVVLIYYMTGAQRVLPIHMHIKLLISGYFFLTGYTHFTHMWQTGGSGSLFVRFFQAMFRANFLSVLLCFCMNRPYQFYYFVPLLSFWLCIVYFVLALPPRISSASVDANPLHYLYLVCKCIGCLGGITVLFMSEVFFERIFVTRPWKALFVTTDDDLHEWWHQWKLDRYTVAFGMIYAACFHIAQKYNVFDDNNHGNLFSRRTSISVTLLALLGVGVYTSFSFLCRNVQNCEEIHSYILFIPIVGYVVLRNISGILRTRYSAFFAWFGRISLELFVCQYHIWLAADRHGVLVLLPGFPTLNMIITSFIFVCASHEVHRLTQILLPYAVPSDWRLVMRNFVIFLIVLIPVARSDGMF", "length": 862 }, "evidence": [ { "id": "F1MBE8", "url": "https://omabrowser.org/oma/group/F1MBE8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1MBE8", "url": "https://www.uniprot.org/uniprotkb/F1MBE8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MBE8", "url": "https://www.uniprot.org/uniprotkb/F1MBE8" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F1MBE8", "url": "https://www.uniprot.org/uniprotkb/F1MBE8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "F1MBE8", "url": "https://www.uniprot.org/uniprotkb/F1MBE8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transferase activity", "id": "GO:0016740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740", "evidence": [ { "database": "UniProtKB", "id": "F1MBE8", "url": "https://www.uniprot.org/uniprotkb/F1MBE8" } ], "pmid": "" }, { "name": "N-acetylneuraminate 9-O-acetyltransferase activity", "id": "GO:0047186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047186", "evidence": [ { "database": "UniProtKB", "id": "F1MBE8", "url": "https://www.uniprot.org/uniprotkb/F1MBE8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" }, { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 330, "end_pos": 332, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 911, "end_pos": 913, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "79499", "name": "", "equation": "a ganglioside GD3 (d18:1(4E)) + acetyl-CoA = a ganglioside Ac-O-7-GD3(d18:1(4E)) + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MBE8-1" ], "evidence": [ { "id": "79499", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/79499" } ] }, { "id": "79555", "name": "", "equation": "CMP-N-acetyl-beta-neuraminate + acetyl-CoA = CMP-N-acetyl-7-O-acetyl-beta-neuraminate + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MBE8-1" ], "evidence": [ { "id": "79555", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/79555" } ] }, { "id": "81827", "name": "", "equation": "CMP-N-acetyl-beta-neuraminate + acetyl-CoA = CMP-N-acetyl-9-O-acetyl-beta-neuraminate + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MBE8-1" ], "evidence": [ { "id": "81827", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/81827" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MBE8", "gene_name": "CASD1", "activity": [ { "ec_number": "2.3.1.45", "activity": "CMP-N-acetyl-beta-neuraminate + acetyl-CoA = CMP-N-acetyl-9-O-acetyl-beta-neuraminate + CoA.", "evidence": [ { "id": "F1MBE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBE8" } ] }, { "ec_number": "2.3.1.45", "activity": "", "evidence": [ { "id": "F1MBE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBE8" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MBE8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 940, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MBE8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MBE8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MBE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBE8" }, { "id": "PF07779", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07779" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cas1p 10 TM acyl transferase", "eco_id": "ECO_0000259", "start_pos": 439, "end_pos": 918, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MBE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBE8" }, { "id": "PF24536", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24536" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NXPE C-terminal", "eco_id": "ECO_0000259", "start_pos": 207, "end_pos": 262, "start_aa": "Trp", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.1.45", "ec_name": "CMP-N-acetyl-beta-neuraminate + acetyl-CoA = CMP-N-acetyl-9-O-acetyl-beta-neuraminate + CoA.", "evidence": [ { "id": "2.3.1.45", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.45" }, { "id": "2.3.1.45", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.1.45" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 189, "end_pos": 191 }, { "start_pos": 284, "end_pos": 286 }, { "start_pos": 318, "end_pos": 320 }, { "start_pos": 330, "end_pos": 332 }, { "start_pos": 384, "end_pos": 386 }, { "start_pos": 911, "end_pos": 913 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044062", "url": "https://www.ensembl.org/id/ENSBTAG00000044062" } ] } } ], "crossref": [ { "id": "E1BPT6", "url": "https://alphafold.ebi.ac.uk/entry/E1BPT6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044062", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044062", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12472", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12472", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12475", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12475", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "784766", "url": "https://www.ncbi.nlm.nih.gov/gene/784766", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein 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"categories": [ "Protein Classification" ] }, { "id": "E1BPT6", "url": "https://www.orthodb.org/?gene=E1BPT6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24012", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24012", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010815855", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010815855", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWH8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWH8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWH8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7Y6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7Y6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7Y6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7Y6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTT7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTT7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTT7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ69-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPT6", "url": "https://www.uniprot.org/uniprotkb/E1BPT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPT6-1", "url": "https://www.uniprot.org/uniprotkb/E1BPT6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKRLDQPQMYPQYTYYYPHYLQTKQSYAPAPHPMAPPSPSTNSSSNHSSSNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAAQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYLKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVSTYQVQSTSWMPHPPYVMQPTGAVITPAMDHPMSMQPASMMGPLTQQMNHLSLGTTGTIQSQDRIMILHQLLCQYMTAAAPMQGTYIPQYTPVPPTAVSIEGVVADTSPQTVAPSSQDTSGQQQQIAVDTASEHASAYSYQQSKP", "length": 437, "header": "tr|E1BPT6-1|E1BPT6_BOVIN Isoform 1 of RNA binding motif single stranded interacting protein 3 OS=Bos taurus OX=9913 GN=RBMS3 PE=4 SV=4 CANONICAL=E1BPT6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWH8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWH8/entry", "sequence": { "sequence": "MGKRLDQPQMYPQYTYYYPHYLQTKQSYAPAPHPMAPPSPSTNSSSNHSSSNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAAQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYLKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVSTYQGAVITPAMDHPMSMQPASMMGPLTQQMNHLSLGTTGTIQSQDRIMILHQLLCQYMTAAAPMQGTYIPQYTPVPPTAVSIEGVVADTSPQTVAPSSQDTSGQQQQIAVDTASEHASAYSYQQSKP", "length": 420, "header": "tr|A0A3Q1LWH8-1|E1BPT6_BOVIN Computationally mapped isoform of RNA binding motif single stranded interacting protein 3 OS=Bos taurus OX=9913 GN=RBMS3 PE=4 SV=2 CANONICAL=E1BPT6-1" }, "locus": { "chromosome": "22", "start_pos": 4651961, "end_pos": 3856819, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077056.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077056.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061777.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061777.2" } ] } }, { "isoform_ac": "A0A3Q1M7Y6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7Y6/entry", "sequence": { "sequence": "MGKRLDQPQMYPQYTYYYPHYLQTKQSYAPAPHPMAPPSPSTNSSSNHSSSNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAAQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYLKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEILRGRTDPRKNYEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVSTYQVQSTSWMPHPPYVMQPTGAVITPAMDHPMSMQPASMMGPLTQQMNHLSLGTTGTYMTAAAPMQGTYIPQYTPVPPTAVSIEGVVADTSPQTVAPSSQDTSGQQQQIAVDTASEHASAYSYQQSK", "length": 433, "header": "tr|A0A3Q1M7Y6-1|E1BPT6_BOVIN Computationally mapped isoform of RNA binding motif single stranded interacting protein 3 OS=Bos taurus OX=9913 GN=RBMS3 PE=4 SV=2 CANONICAL=E1BPT6-1" }, "locus": { "chromosome": "22", "start_pos": 4627477, "end_pos": 3856819, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072377.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072377.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066199.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066199.2" } ] } }, { "isoform_ac": "A0A3Q1MTT7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTT7/entry", "sequence": { "sequence": "MEMDVEGVSPRPEPIPRSQGAGGACQAPSQPPQPQPQPPLLPPQHPAPDEPPGESAGAEDSDDPEARPSGDKGESKRTAASKPSSVPSYSRWSSSQPHQSSSTVRAYQTSKSRVTMSPGFSSQWNSSQPAWNTYSFPRASLHYQSHASYTYCTGHPASYAPAPHPMAPPSPSTNSSSNHSSSNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAAQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYLKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVSTYQVQSTSWMPHPPYVMQPTGAVITPAMDHPMSMQPASMMGPLTQQMNHLSLGTTGTIQSQDRIMILHQLLCQYMTAAAPMQGTYIPQYTPVPPTAVSIEGVVADTSPQTVAPSSQDTSGQQQQIAVDTASEHASAYSYQQSKP", "length": 568, "header": "tr|A0A3Q1MTT7-1|E1BPT6_BOVIN Computationally mapped isoform of RNA binding motif single stranded interacting protein 3 OS=Bos taurus OX=9913 GN=RBMS3 PE=4 SV=2 CANONICAL=E1BPT6-1" }, "locus": { "chromosome": "22", "start_pos": 4651961, "end_pos": 2984947, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075715.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075715.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073805.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073805.2" } ] } }, { "isoform_ac": "A0AAA9TQ69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ69/entry", "sequence": { "sequence": "MGKRLDQPQMYPQYTYYYPHYLQTKQSYAPAPHPMAPPSPSTNSSSNHSSSNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAAQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYLKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVSTYQVQSTSWMPHPPYVMQPTGAVITPAMDHPMSMQPASMMGPLTQQMNHLSLGTTGTIQSQDRIMILHQLLCQGVVADTSPQTVAPSSQDTSGQQQQIAVDTASEHASAYSYQQSKP", "length": 410, "header": "tr|A0AAA9TQ69-1|E1BPT6_BOVIN Computationally mapped isoform of RNA binding motif single stranded interacting protein 3 OS=Bos taurus OX=9913 GN=RBMS3 PE=4 SV=1 CANONICAL=E1BPT6-1" }, "locus": { "chromosome": "22", "start_pos": 4651961, "end_pos": 3856819, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107038.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107038.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098537.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098537.1" } ] } }, { "isoform_ac": "E1BPT6-1", "url": "https://www.uniprot.org/uniprotkb/E1BPT6/entry", "sequence": { "sequence": "MGKRLDQPQMYPQYTYYYPHYLQTKQSYAPAPHPMAPPSPSTNSSSNHSSSNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAAQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYLKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVSTYQVQSTSWMPHPPYVMQPTGAVITPAMDHPMSMQPASMMGPLTQQMNHLSLGTTGTIQSQDRIMILHQLLCQYMTAAAPMQGTYIPQYTPVPPTAVSIEGVVADTSPQTVAPSSQDTSGQQQQIAVDTASEHASAYSYQQSKP", "length": 437, "header": "tr|E1BPT6-1|E1BPT6_BOVIN Isoform 1 of RNA binding motif single stranded interacting protein 3 OS=Bos taurus OX=9913 GN=RBMS3 PE=4 SV=4 CANONICAL=E1BPT6-1" }, "locus": { "chromosome": "22", "start_pos": 4651961, "end_pos": 3856819, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061510.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061510.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053359.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053359.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 388, "start_aa": "Thr", "end_pos": 388, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr388", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BPT6", "url": "https://www.uniprot.org/uniprotkb/E1BPT6" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "E1BPT6", "url": "https://www.uniprot.org/uniprotkb/E1BPT6" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BPT6", "url": "https://www.uniprot.org/uniprotkb/E1BPT6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BPT6", "url": "https://www.uniprot.org/uniprotkb/E1BPT6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "E1BPT6", "url": "https://www.uniprot.org/uniprotkb/E1BPT6" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "E1BPT6", "url": "https://www.uniprot.org/uniprotkb/E1BPT6" } ], "pmid": "" }, { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "E1BPT6", "url": "https://www.uniprot.org/uniprotkb/E1BPT6" } ], "pmid": "" }, { "name": "defense response to tumor cell", "id": "GO:0002357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002357", "evidence": [ { "database": "UniProtKB", "id": "E1BPT6", "url": "https://www.uniprot.org/uniprotkb/E1BPT6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "poly(A) binding", "id": "GO:0008143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008143", "evidence": [ { "database": "UniProtKB", "id": "E1BPT6", "url": "https://www.uniprot.org/uniprotkb/E1BPT6" } ], "pmid": "" }, { "name": "poly(U) RNA binding", "id": "GO:0008266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008266", "evidence": [ { "database": "UniProtKB", "id": "E1BPT6", "url": "https://www.uniprot.org/uniprotkb/E1BPT6" } ], "pmid": "" }, { "name": "mRNA 3'-UTR AU-rich region binding", "id": "GO:0035925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035925", "evidence": [ { "database": "UniProtKB", "id": "E1BPT6", "url": "https://www.uniprot.org/uniprotkb/E1BPT6" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BPT6", "url": "https://www.uniprot.org/uniprotkb/E1BPT6" } ], "pmid": "" }, { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "E1BPT6", "url": "https://www.uniprot.org/uniprotkb/E1BPT6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 232, "end_pos": 234, "annotation": "n_glycosylation_sequon" }, { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" }, { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPT6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 437, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPT6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPT6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPT6" }, { "id": "PS50102", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50102" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RRM", "eco_id": "ECO_0000259", "start_pos": 61, "end_pos": 134, "start_aa": "Thr", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 388 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 232, "end_pos": 234 }, { "start_pos": 43, "end_pos": 45 }, { "start_pos": 47, "end_pos": 49 }, { "start_pos": 52, "end_pos": 54 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MDT4-1", "uniprot_ac": "F1MDT4", "uniprot_id": "F1MDT4_BOVIN", "mass": { "chemical_mass": 80985.0, "monoisotopic_mass": 80985.0 }, "refseq": { "ac": "XP_059746080", "name": "zinc finger and BTB domain-containing protein 20", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746080" }, "gene_names": [ { "name": "ZBTB20", "type": "recommended", "evidence": [ { "id": "F1MDT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDT4" } ] }, { "name": "ZBTB20", "type": "synonym", "evidence": [ { "id": "XP_059746080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746080" } ] } ], "protein_names": [ { "name": "Zinc finger and BTB domain-containing protein 20", "type": "recommended", "evidence": [ { "id": "F1MDT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDT4/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein 288", "type": "synonym", "evidence": [ { "id": "F1MDT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDT4/entry#names_and_taxonomy" } ] }, { "name": "zinc finger and BTB domain-containing protein 20", "type": "synonym", "evidence": [ { "id": "XP_059746080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746080" } ] } ], "function": [ { "annotation": "May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.", "evidence": [ { "database": "UniProtKB", "id": "F1MDT4", "url": "https://www.uniprot.org/uniprotkb/F1MDT4#function" }, { "database": "UniProtKB", "id": "ARBA00053801", "url": "https://www.uniprot.org/uniprotkb/ARBA00053801#function" }, { "database": "UniProtKB", "id": "A0A3Q1MWJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWJ3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MDT4", "url": "https://www.uniprot.org/uniprotkb/F1MDT4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZBTB20", "url": "https://www.uniprot.org/uniprotkb/F1MDT4", "locus": { "chromosome": "1", "start_pos": 58974734, "end_pos": 59030035, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011928", "url": "https://www.ensembl.org/id/ENSBTAG00000011928" } ] } } ], "crossref": [ { "id": "F1MDT4", "url": "https://alphafold.ebi.ac.uk/entry/F1MDT4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011928", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011928", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18208", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18208", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508864", "url": "https://www.ncbi.nlm.nih.gov/gene/508864", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508864", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508864", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DEFSCYD", "url": "https://omabrowser.org/oma/group/DEFSCYD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059746080", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746080", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDT4", "url": "https://www.uniprot.org/uniprotkb/F1MDT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDT4-1", "url": "https://www.uniprot.org/uniprotkb/F1MDT4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLERKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPGPALIHSTHSLTNSHAHPGSSDCDISCKGMTERIHSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVSHHETALGLPRDHHIEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTEDTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPAQPEQAAEAPAEGAPQPHQLETGASSPERSNEVEVDNTVITVSNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQFVTVSQPGLSTFTAQLPAPQPLAPSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSLKDYLIKHMVTHTGVRAYQCSICNKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVALHSASNGTPPAGTPPGSRAGPPGVGACTEGTTYVCSVCPAKFDQIEQFNDHMRMHVSDG", "length": 741, "header": "tr|F1MDT4-1|F1MDT4_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 20 OS=Bos taurus OX=9913 GN=ZBTB20 PE=4 SV=3 CANONICAL=F1MDT4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MWJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWJ3/entry", "sequence": { "sequence": "MFEKESEETLGDISCKGMTERIHSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVSHHETALGLPRDHHIEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTEDTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPAQPEQAAEAPAEGAPQPHQLETGASSPERSNEVEVDNTVITVSNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQFVTVSQPGLSTFTAQLPAPQPLAPSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSLKDYLIKHMVTHTGVRAYQCSICNKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVALHSASNGTPPAGTPPGSRAGPPGVGACTEGTTYVCSVCPAKFDQIEQFNDHMRMHVSDG", "length": 685, "header": "tr|A0A3Q1MWJ3-1|F1MDT4_BOVIN Computationally mapped isoform of Zinc finger and BTB domain-containing protein 20 OS=Bos taurus OX=9913 GN=ZBTB20 PE=4 SV=2 CANONICAL=F1MDT4-1" }, "locus": { "chromosome": "1", "start_pos": 59003661, "end_pos": 58975738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083461.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083461.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059858.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059858.2" } ] } }, { "isoform_ac": "F1MDT4-1", "url": "https://www.uniprot.org/uniprotkb/F1MDT4/entry", "sequence": { "sequence": "MLERKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPGPALIHSTHSLTNSHAHPGSSDCDISCKGMTERIHSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVSHHETALGLPRDHHIEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTEDTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPAQPEQAAEAPAEGAPQPHQLETGASSPERSNEVEVDNTVITVSNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQFVTVSQPGLSTFTAQLPAPQPLAPSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSLKDYLIKHMVTHTGVRAYQCSICNKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVALHSASNGTPPAGTPPGSRAGPPGVGACTEGTTYVCSVCPAKFDQIEQFNDHMRMHVSDG", "length": 741, "header": "tr|F1MDT4-1|F1MDT4_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 20 OS=Bos taurus OX=9913 GN=ZBTB20 PE=4 SV=3 CANONICAL=F1MDT4-1" }, "locus": { "chromosome": "1", "start_pos": 59021496, "end_pos": 58975738, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015819.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015819.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015819.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015819.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 695, "start_aa": "Thr", "end_pos": 695, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr695", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:508864", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508864", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1W2Q6H7-1", "protein_name": "Zinc finger and BTB domain-containing protein 20", "gene_name": "Zbtb20", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLERKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVSHHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTEDTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGAGATREGQVEAAQPEQAAEAPAESSAQPNQLETGASSPERSTEVEMDNTVITVSNSSDKGVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLTGQQTQFVTVSQPGLSTFTAQLPAPQPLASSASHSTASGQGDKKPYECTLCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSLKDYLIKHMVTHTGVRAYQCSICNKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVALHSASNGTPPAGTPPGARAGPPGVVACTEGTTYVCSVCPAKFDQIEQFNDHMRMHVSDG", "length": 741 }, "evidence": [ { "id": "F1MDT4", "url": "https://omabrowser.org/oma/group/F1MDT4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A286ZTI8-1", "protein_name": "Zinc finger and BTB domain-containing protein 20", "gene_name": "ZBTB20", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLERKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHPTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVSHHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTEDTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPAAARDGPAEPAQPEQAAEAPAEGAPQPHQLETGASSPERSNEVEMDNTVITVSNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQFVTVSQPGLSTFTAQLPAPQPLAPSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSLKDYLIKHMVTHTGVRAYQCSICNKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVALHSASNGTPPAGTPPGARAGPPGVVACTEGTTYVCSVCPAKFDQIEQFNDHMRMHVSDG", "length": 741 }, "evidence": [ { "id": "F1MDT4", "url": "https://omabrowser.org/oma/group/F1MDT4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XLI4-1", "protein_name": "Zinc finger and BTB domain-containing protein 20", "gene_name": "ZBTB20", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAYCNISCKGMTERIHSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGEVYPVIQDSGQETPRGTPESGTSGQSTDTESGYLQSHSQHSVDRIYSALYACSMQNGSGERSFYSGAVVSHHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLMGNIHIKQEMEDDYDYYGQQRVQILERNESEECTEDTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFMTGLGRDGQQESSQADQNDIPGDGSQPQQQQQQHVDANSSSPERSNDVEMDSKGLTVNNSTEKGALQPSVNTTVAQPLPTTQIYLRQTESLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQSAGSGPKPFLFSLPQPIAGQQTQFVTVSQPGLSTFTAQLPAPQPLAPSAGHSTAGGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSLKDYLIKHMVTHTGVRAYQCSICNKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVALHSATNGTPGATGTGARAVPAGVVACTEGTTYVCSVCPAKFDQIEHFNDHMRMHVSDG", "length": 679 }, "evidence": [ { "id": "F1MDT4", "url": "https://omabrowser.org/oma/group/F1MDT4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7FUF5-1", "protein_name": "Zinc finger and BTB domain-containing protein 20", "gene_name": "Zbtb20", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQRGNNRKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVSHHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTEDTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGAGATREGQAEPAQPEQAAEASTEGSAQPNQLETGASSPERSNEVEMDNTVITVSNSSDKGVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLTGQQTQFVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSLKDYLIKHMVTHTGVRAYQCSICNKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVALHSASNGTPPAGTPPGARAGPPGVVACTEGTTYVCSVCPAKFDQMEQFNDHMRMHVSDG", "length": 744 }, "evidence": [ { "id": "F1MDT4", "url": "https://omabrowser.org/oma/group/F1MDT4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8K0L9-1", "protein_name": "Zinc finger and BTB domain-containing protein 20", "gene_name": "Zbtb20", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLERKKPKTAENQKASEENEITQPGGSSAKPALPCLNFEAVLSPAPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVSHHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTEDTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGAAAPRDGQAEPAQPEQAAEAPAESSAQPNQLEPGASSPERSNESEMDNTVITVSNSSDKGVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLTGQQTQFVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGDKKPYECTLCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSLKDYLIKHMVTHTGVRAYQCSICNKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVALHSASNGTPPAGTPPGARAGPPGVVACTEGTTYVCSVCPAKFDQIEQFNDHMRMHVSDG", "length": 741 }, "evidence": [ { "id": "F1MDT4", "url": "https://omabrowser.org/oma/group/F1MDT4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HC78-1", "protein_name": "Zinc finger and BTB domain-containing protein 20", "gene_name": "ZBTB20", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLERKKPKTAENQKASEENEITQPGGSSAKPGLPCLNFEAVLSPDPALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVSHHETALGLPRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILERNESEECTEDTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGPGAARDSQAEPTQPEQAAEAPAEGGPQTNQLETGASSPERSNEVEMDSTVITVSNSSDKSVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFLFSLPQPLAGQQTQFVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSLKDYLIKHMVTHTGVRAYQCSICNKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVALHSASNGTPPAGTPPGARAGPPGVVACTEGTTYVCSVCPAKFDQIEQFNDHMRMHVSDG", 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Classification" ] }, { "id": "IPR028392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3H6", "url": "https://www.orthodb.org/?gene=A0A3Q1M3H6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MWN6", "url": "https://www.orthodb.org/?gene=A0A3Q1MWN6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MF11", "url": "https://www.orthodb.org/?gene=F1MF11", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N3D6", "url": "https://www.orthodb.org/?gene=G3N3D6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10336", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10336:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00387", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00387", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00388", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00388", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09279", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09279", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16457", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16457", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1855204", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855204", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "33179", "url": "https://www.rhea-db.org/rhea/33179", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M3H6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3H6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3H6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3H6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWN6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWN6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF11", "url": "https://www.uniprot.org/uniprotkb/F1MF11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF11-1", "url": "https://www.uniprot.org/uniprotkb/F1MF11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3D6", "url": "https://www.uniprot.org/uniprotkb/G3N3D6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N3D6-1", "url": "https://www.uniprot.org/uniprotkb/G3N3D6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMTNVTTDYCIDIIRKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFQDKLDLSSIDTGETKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYNNGTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQHPDAKESGKKAHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDAQQNPGKETGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKTNGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCSKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHNSSENTCHYIRKRSIGDKILRRTASAPAKGRKKSKMGFQEMVEMKDSVSEAARDQDGVLRRTTRSLQARPVSMPVDRSLLGALSLPVSETTKDTEGKENSQAEDKDARRDGKASVKDQHLPNFNKKLSSSSSALIHKDISQGNSAVSTANLSITEQLVPGPKGGRTKSNMLSDCWEHQCLSRSLSPRQHLAHDPAVSPSKDLCGVKTKENGNAGGFVVGKSTLSGSILSQSNLEIKKLEGNWDKGRAATSFSLSDVSTLCSDAPDLHSTAILQESEISHLIDNVTLTNENEPGSSISALIGQFDETGNQANPTVVSHLQSPSVMSGHPPVPTMDLKMPFKPGFSNGKPKSSFLCSSPEQIALSGHETCECSTHTAVGETMCTPVSKMKPDNDLSGKAMTGAIENNLPQSSNTSHCWLPESPTHGKDWEILKNPSPATSTDLTLEDVIAAPTLSLNSGESSLVEMDGDSENLSLTTYEYRREGTSHLTSPLKVKYSPAAVEHFQRGLRNGYCKETLHPSVSEIFNNTQDVKNQNISHLAYQGAGFMHNHFSNSDAKTNQTSGPLPCAHDLHAPAPEQSTHSALKLSSPCKSKSLGDLTSEDIACNFESKYQCISKSFVTTGIRDKKGMTVKTKSLEPMDALTEQLRKLVSFDQEDGCQVLYSKQDANQFPRALVRKLSSRSQSRVRNIASRAKEKQEANRQKSVNPSTVGGVVLRSKPCAPAPTGNRHSTGSYIAGYLRSAKGGSLEGRGIPEGACAALRSGHVDRFCSHHSVLQTEPSSDDKPEIYFLLRL", "length": 1689, "header": "tr|F1MF11-1|F1MF11_BOVIN Isoform 1 of Phosphoinositide phospholipase C OS=Bos taurus OX=9913 GN=PLCH1 PE=4 SV=3 CANONICAL=F1MF11-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3H6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3H6/entry", "sequence": { "sequence": "MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMTNVTTDYCIDIIRKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFQDKLDLSSIDTGETKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYNNGTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQHPDAKESGKKAHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDAQQNPGKETGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKTNGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCSKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHNSSENTCHYIRKRSIGDKILRRTASAPAKGRKKSKMGFQEMVEMKDSVSEAARDQDGVLRRTTRSLQARPVSMPVDRSLLGALSLPVSETTKDTEGKENSQVQI", "length": 1002, "header": "tr|A0A3Q1M3H6-1|F1MF11_BOVIN Computationally mapped isoform of Phosphoinositide phospholipase C OS=Bos taurus OX=9913 GN=PLCH1 PE=4 SV=2 CANONICAL=F1MF11-1" }, "locus": { "chromosome": "1", "start_pos": 112165494, "end_pos": 111977360, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085396.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085396.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068056.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068056.2" } ] } }, { "isoform_ac": "A0A3Q1MWN6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWN6/entry", "sequence": { "sequence": "MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMTNVTTDYCIDIIRKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFQDKLDLSSIDTGETKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYNNGTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQHPDAKESGKKAHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDAQQNPGKETGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKTNGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCSKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEIYGKNRQLQGLKGLFNKNPRHNSSENTCHYIRKRSIGDKILRRTASAPAKGRKKSKMGFQEMVEMKDSVSEAARDQDGVLRRTTRSLQARPVSMPVDRSLLGALSLPVSETTKDTEGKENSQDASCCTLIEQAKAEMKVLFPRQLEYIMKMEISKT", "length": 1013, "header": "tr|A0A3Q1MWN6-1|F1MF11_BOVIN Computationally mapped isoform of Phosphoinositide phospholipase C OS=Bos taurus OX=9913 GN=PLCH1 PE=4 SV=2 CANONICAL=F1MF11-1" }, "locus": { "chromosome": "1", "start_pos": 112258936, "end_pos": 111977360, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079453.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079453.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059942.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059942.2" } ] } }, { "isoform_ac": "F1MF11-1", "url": "https://www.uniprot.org/uniprotkb/F1MF11/entry", "sequence": { "sequence": "MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMTNVTTDYCIDIIRKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFQDKLDLSSIDTGETKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYNNGTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQHPDAKESGKKAHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDAQQNPGKETGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKTNGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCSKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHNSSENTCHYIRKRSIGDKILRRTASAPAKGRKKSKMGFQEMVEMKDSVSEAARDQDGVLRRTTRSLQARPVSMPVDRSLLGALSLPVSETTKDTEGKENSQAEDKDARRDGKASVKDQHLPNFNKKLSSSSSALIHKDISQGNSAVSTANLSITEQLVPGPKGGRTKSNMLSDCWEHQCLSRSLSPRQHLAHDPAVSPSKDLCGVKTKENGNAGGFVVGKSTLSGSILSQSNLEIKKLEGNWDKGRAATSFSLSDVSTLCSDAPDLHSTAILQESEISHLIDNVTLTNENEPGSSISALIGQFDETGNQANPTVVSHLQSPSVMSGHPPVPTMDLKMPFKPGFSNGKPKSSFLCSSPEQIALSGHETCECSTHTAVGETMCTPVSKMKPDNDLSGKAMTGAIENNLPQSSNTSHCWLPESPTHGKDWEILKNPSPATSTDLTLEDVIAAPTLSLNSGESSLVEMDGDSENLSLTTYEYRREGTSHLTSPLKVKYSPAAVEHFQRGLRNGYCKETLHPSVSEIFNNTQDVKNQNISHLAYQGAGFMHNHFSNSDAKTNQTSGPLPCAHDLHAPAPEQSTHSALKLSSPCKSKSLGDLTSEDIACNFESKYQCISKSFVTTGIRDKKGMTVKTKSLEPMDALTEQLRKLVSFDQEDGCQVLYSKQDANQFPRALVRKLSSRSQSRVRNIASRAKEKQEANRQKSVNPSTVGGVVLRSKPCAPAPTGNRHSTGSYIAGYLRSAKGGSLEGRGIPEGACAALRSGHVDRFCSHHSVLQTEPSSDDKPEIYFLLRL", "length": 1689, "header": "tr|F1MF11-1|F1MF11_BOVIN Isoform 1 of Phosphoinositide phospholipase C OS=Bos taurus OX=9913 GN=PLCH1 PE=4 SV=3 CANONICAL=F1MF11-1" }, "locus": { "chromosome": "1", "start_pos": 112167876, "end_pos": 111977360, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010937.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010937.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010937.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010937.6" } ] } }, { "isoform_ac": "G3N3D6-1", "url": "https://www.uniprot.org/uniprotkb/G3N3D6/entry", "sequence": { "sequence": "MSYWNLEKRNCVQYRRHFLVDNSPFHVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMTNVTTDYCIDIIRKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFQDKLDLSSIDTGETKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYNNGTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQHPDAKESGKKAHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDAQQNPGKETGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKTNGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCSKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEIYGKNRQLQGLKGLFNKNPRHNSSENTCHYIRKRSIGDKILRRTASAPAKGRKKSKMGFQEMVEMKDSVSEAARDQDGVLRRTTRSLQARPVSMPVDRSLLGALSLPVSETTKDTEGKENSQAEDKDARRDGKASVKDQHLPNFNKKLSSSSSALIHKDISQGNSAVSTANLSITEQLVPGPKGGRTKSNMLSDCWEHQCLSRSLSPRQHLAHDPAVSPSKDLCGVKTKENGNAGGFVVGKSTLSGSILSQSNLEIKKLEGNWDKGRAATSFSLSDVSTLCSDAPDLHSTAILQESEISHLIDNVTLTNENEPGSSISALIGQFDETGNQANPTVVSHLQSPSVMSGHPPVPTMDLKMPFKPGFSNGKPKSSFLCSSPEQIALSGHETCECSTHTAVGETMCTPVSKMKPDNDLSGKAMTGAIENNLPQSSNTSHCWLPESPTHGKDWEILKNPSPATSTDLTLEDVIAAPTLSLNSGESSLVEMDGDSENLSLTTYEYRREGTSHLTSPLKVKYSPAAVEHFQRGLRNGYCKETLHPSVSEIFNNTQDVKNQNISHLAYQGAGFMHNHFSNSDAKTNQTSGPLPCAHDLHAPAPEQSTHSALKLSSPCKSKSLGDLTSEDIACNFESKYQCISKSFVTTGIRDKKGMTVKTKSLEPMDALTEQLRKLVSFDQEDGCQVLYSKQDANQFPRALVRKLSSRSQSRVRNIASRAKEKQEANRQKSVNPSTVGGVVLRSKPCAPAPTGNRHSTGSYIAGYLRSAKGGSLEGRGIPEGACAALRSGHVDRFCSHHSVLQTEPSSDDKPEIYFLLRL", "length": 1681, "header": "tr|G3N3D6-1|F1MF11_BOVIN Computationally mapped isoform of Phosphoinositide phospholipase C OS=Bos taurus OX=9913 GN=PLCH1 PE=4 SV=3 CANONICAL=F1MF11-1" }, "locus": { "chromosome": "1", "start_pos": 112167876, "end_pos": 111945804, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065611.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065611.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056439.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056439.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-1855204", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855204", "resource": "Reactome", "description": "Synthesis of IP3 and IP4 in the cytosol" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphatidylinositol-4,5-bisphosphate phospholipase C activity", "id": "GO:0004435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004435", "evidence": [ { "database": "UniProtKB", "id": "F1MF11", "url": "https://www.uniprot.org/uniprotkb/F1MF11" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MF11", "url": "https://www.uniprot.org/uniprotkb/F1MF11" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MF11", "url": "https://www.uniprot.org/uniprotkb/F1MF11" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MF11", "url": "https://www.uniprot.org/uniprotkb/F1MF11" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MF11", "url": "https://www.uniprot.org/uniprotkb/F1MF11" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1MF11", "url": "https://www.uniprot.org/uniprotkb/F1MF11" } ], "pmid": "" }, { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "F1MF11", "url": "https://www.uniprot.org/uniprotkb/F1MF11" } ], "pmid": "" }, { "name": "release of sequestered calcium ion into cytosol", "id": "GO:0051209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051209", "evidence": [ { "database": "UniProtKB", "id": "F1MF11", "url": "https://www.uniprot.org/uniprotkb/F1MF11" } ], "pmid": "" }, { "name": "phosphatidylinositol-mediated signaling", "id": "GO:0048015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048015", "evidence": [ { "database": "UniProtKB", "id": "F1MF11", "url": "https://www.uniprot.org/uniprotkb/F1MF11" } ], "pmid": "" }, { "name": "phosphatidylinositol metabolic process", "id": "GO:0046488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046488", "evidence": [ { "database": "UniProtKB", "id": "F1MF11", "url": "https://www.uniprot.org/uniprotkb/F1MF11" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1048, "end_pos": 1050, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1181, "end_pos": 1183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1309, "end_pos": 1311, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1368, "end_pos": 1370, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1422, "end_pos": 1424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1431, "end_pos": 1433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1455, "end_pos": 1457, "annotation": "n_glycosylation_sequon" }, { "start_pos": 248, "end_pos": 250, "annotation": "n_glycosylation_sequon" }, { "start_pos": 480, "end_pos": 482, "annotation": "n_glycosylation_sequon" }, { "start_pos": 899, "end_pos": 901, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "33179", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SDK5-1", "A0AAA9S613-1", "G3N0S6-1", "F1MF11-1", "E1BH60-1", "A0A3Q1NG43-1", "P10895-1", "A0AAF6YYJ2-1", "P10894-1", "P21671-1", "P08487-1", "Q07722-1", "Q1RML2-1", "A7MB47-1", "F1MSD7-1", "E1B7M6-1", "A0A3Q1MTC3-1", "A0AAA9SMQ6-1" ], "evidence": [ { "id": "33179", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33179" } ] }, { "id": "R-BTA-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P10895-1", "A0A3Q1NG43-1", "A0AAA9S613-1", "F1MF11-1", "A0AAA9SDK5-1" ], "evidence": [ { "id": "R-BTA-1855221", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855221" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MTC3", "gene_name": "PLCL1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0A3Q1MTC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTC3" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0A3Q1MTC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTC3" } ] } 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"A0AAA9S613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S613" } ] } ] }, { "uniprot_ac": "A0AAA9SDK5", "gene_name": "PLCD3", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0AAA9SDK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A0AAA9SDK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDK5" } ] } ] }, { "uniprot_ac": "A0AAA9SMQ6", "gene_name": "PLCG1", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A0AAA9SMQ6", "database": "UniProtKB", "url": 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1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "A7MB47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB47" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "A7MB47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB47" } ] } ] }, { "uniprot_ac": "E1B7M6", "gene_name": "PLCB2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).", "evidence": [ { "id": "E1B7M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M6" } ] }, { "ec_number": "3.1.4.11", "activity": "", "evidence": [ { "id": "E1B7M6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7M6" } ] } ] }, { "uniprot_ac": "E1BH60", "gene_name": "PLCL2", "activity": [ { "ec_number": "3.1.4.11", "activity": "a 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MI98-1", "uniprot_ac": "F1MI98", "uniprot_id": "F1MI98_BOVIN", "mass": { "chemical_mass": 51138.0, "monoisotopic_mass": 51138.0 }, "refseq": { "ac": "NP_001179454", "name": "keratin, type I cuticular Ha6", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179454" }, "gene_names": [ { "name": "KRT35", "type": "recommended", "evidence": [ { "id": "F1MI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI98" } ] }, { "name": "KRT36", "type": "recommended", "evidence": [ { "id": "F1MI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI98" } ] }, { "name": "KRT36", "type": "synonym", "evidence": [ { "id": "NP_001179454", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179454" }, { "id": "F1MI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI98" } ] } ], "protein_names": [ { "name": "Keratin 36", "type": "synonym", "evidence": [ { "id": "F1MI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI98/entry#names_and_taxonomy" } ] }, { "name": "keratin, type I cuticular Ha6", "type": "synonym", "evidence": [ { "id": "NP_001179454", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179454" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MI98", "url": "https://www.uniprot.org/uniprotkb/F1MI98" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRT36", "url": "https://www.uniprot.org/uniprotkb/F1MI98", "locus": { "chromosome": "19", "start_pos": 41678479, "end_pos": 41695018, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000046124", "url": "https://www.ensembl.org/id/ENSBTAG00000046124" } ] } } ], "crossref": [ { "id": "F1MI98", "url": "https://alphafold.ebi.ac.uk/entry/F1MI98", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006807", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006807", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000037560", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037560", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000046124", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046124", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "520668", "url": "https://www.ncbi.nlm.nih.gov/gene/520668", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520668", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520668", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AVRVPYI", "url": "https://omabrowser.org/oma/group/AVRVPYI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A140T8B6", "url": "https://www.orthodb.org/?gene=A0A140T8B6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZF2", "url": "https://www.orthodb.org/?gene=A0A3Q1LZF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MI98", "url": "https://www.orthodb.org/?gene=F1MI98", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239:SF204", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239:SF204", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179454", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A140T8B6", "url": "https://www.uniprot.org/uniprotkb/A0A140T8B6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T8B6-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T8B6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI98", "url": "https://www.uniprot.org/uniprotkb/F1MI98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI98-1", "url": "https://www.uniprot.org/uniprotkb/F1MI98-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASQFCSPIFSSGSIRGHCGATSGISRVSCVRSVGSCRGPSLAGSASSVRLGLSSLGSCLPGSFLSSGFHSSGFAGAGGWFCEGSFNGNEKETMQFLNDRLASYLEKVRQLERENAELESRIREWYESQAPYICPDYQCYFKTIEELQQKILLTKADNARLVLQIDNAKLAADDFRTKYETELGMRQLVEADTNGLRRILDELTLCKADLEMQVESLKEELICLKKNHEEEVNTLRCQLGDRLNVEVDAAPPVDLNKILDEMRCQYETLVENNRRDVEAWFNTQTEELNQQVVSSSEQLQCCQTEIIELRRNVNALEIELQAQHSMRNSLESTLAETEARYSSQLAQMQGLIGNVEAQLAEIRCDLERQNQEYQVLLDVKARLESEIATYRRLLEGEDCKLPAHPCATECKPAVRVPYVSTGPCAPAPQLSTQIRTITEEIRDGKIISSREHVQPL", "length": 456, "header": "tr|F1MI98-1|F1MI98_BOVIN Isoform 1 of Keratin 36 OS=Bos taurus OX=9913 GN=KRT36 PE=3 SV=3 CANONICAL=F1MI98-1" }, "isoforms": [ { "isoform_ac": "A0A140T8B6-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T8B6/entry", "sequence": { "sequence": "MASQFCSPIFSSGSIRGHCGATSGISRVSCVRSVGSCRGPSLAGSASSVRLGLSSLGSCLPGSFLSSGFHSSGFAGAGGWFCEGSFNGNEKETMQFLNDRLASYLEKVRQLERENAELESRIHEWCEQQVPYLCPDYQSYFQTIEELQKKTLCTKSENARLVVQIDNAKLAADDFRTKYETEVSMRQLVESDMNGLRRILDDLTLCKADLEAQVESLKEELLCLKKNHEEEVNSLRCQLGDRLNVEVDAAPPVDLNRVLNEMRCQYETLVENNRREAEDWFNTQTEELNQQVVSSSEQLQSYQAEIIELRRTVNALEIELQAQHSMRDALESTLAETEARYSSQLAQMQGLIGNVESQLAEIRCDLERQNQEYQVLLDVRARLECEINTYRGLLDSEDCKLPCNPCAPDHSPSKSCLPCLPAASCGPGMARTTCSPRPICVPCPGSRF", "length": 448, "header": "tr|A0A140T8B6-1|F1MI98_BOVIN Computationally mapped isoform of Keratin 36 OS=Bos taurus OX=9913 GN=KRT36 PE=3 SV=2 CANONICAL=F1MI98-1" }, "locus": { "chromosome": "19", "start_pos": 41694819, "end_pos": 41678835, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043064.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043064.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000040659.4", "url": "https://www.ensembl.org/id/ENSBTAP00000040659.4" } ] } }, { "isoform_ac": "A0A3Q1LZF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZF2/entry", "sequence": { "sequence": "MASQFCSPIFSSGSIRGHCGATSGISRVSCVRSVGSCRGPSLAGSASSVRLGLSSLGSCLPGSFLSSGFHSSGFAGAGGWFCEGSFNGNEKETMQFLNDRLASYLEKVRQLERENAELESRIREWYESQAPYICPDYQCYFKTIEELQQKILLTKADNARLVLQIDNAKLAADDFRTKYETELGMRQLVEADTNGLRRILDELTLCKADLEMQVESLKEELICLKKNHEEEVNTLRCQLGDRLNVEVDAAPPVDLNKILDEMRCQYETLVENNRRDVEAWFNTQTEELNQQVVSSSEQLQSYQAEIIELRRTVNALEIELQAQHSMRDALESTLAETEARYSSQLAQMQGLIGNVESQLAEIRCDLERQNQEYQVLLDVRARLECEINTYRGLLDSEDCKLPCNPCAPDHSPSKSCLPCLPAASCGPGMARTTCSPRPICVPCPGSRF", "length": 448, "header": "tr|A0A3Q1LZF2-1|F1MI98_BOVIN Computationally mapped isoform of Keratin 36 OS=Bos taurus OX=9913 GN=KRT36 PE=3 SV=2 CANONICAL=F1MI98-1" }, "locus": { "chromosome": "19", "start_pos": 41694819, "end_pos": 41678835, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074051.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074051.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066229.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066229.2" } ] } }, { "isoform_ac": "F1MI98-1", "url": "https://www.uniprot.org/uniprotkb/F1MI98/entry", "sequence": { "sequence": "MASQFCSPIFSSGSIRGHCGATSGISRVSCVRSVGSCRGPSLAGSASSVRLGLSSLGSCLPGSFLSSGFHSSGFAGAGGWFCEGSFNGNEKETMQFLNDRLASYLEKVRQLERENAELESRIREWYESQAPYICPDYQCYFKTIEELQQKILLTKADNARLVLQIDNAKLAADDFRTKYETELGMRQLVEADTNGLRRILDELTLCKADLEMQVESLKEELICLKKNHEEEVNTLRCQLGDRLNVEVDAAPPVDLNKILDEMRCQYETLVENNRRDVEAWFNTQTEELNQQVVSSSEQLQCCQTEIIELRRNVNALEIELQAQHSMRNSLESTLAETEARYSSQLAQMQGLIGNVEAQLAEIRCDLERQNQEYQVLLDVKARLESEIATYRRLLEGEDCKLPAHPCATECKPAVRVPYVSTGPCAPAPQLSTQIRTITEEIRDGKIISSREHVQPL", "length": 456, "header": "tr|F1MI98-1|F1MI98_BOVIN Isoform 1 of Keratin 36 OS=Bos taurus OX=9913 GN=KRT36 PE=3 SV=3 CANONICAL=F1MI98-1" }, "locus": { "chromosome": "19", "start_pos": 41694819, "end_pos": 41691097, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006440.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006440.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006440.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006440.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520668", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520668", "resource": "KEGG Pathway" }, { "id": "R-BTA-6805567", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "resource": "Reactome", "description": "Keratinization" }, { "id": "R-BTA-6809371", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" } ], "orthologs": [ { "uniprot_canonical_ac": "B1AQ75-1", "protein_name": "Keratin, type I cuticular Ha6", "gene_name": "Krt36", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATQICTPTFSAGSAKGLCGTSGSFSRISSIHSMGSCRAPSLVGTVGSVSSFRTGFSGPGSCLPGSYLSSGCHSSGFAGSGGWFCEGAFNGNEKATMQILNDRLANYLEKVRQLEQENTQLECRIREWYECQIPYICPDYQSYFKTAEELQQKILLTKSENARLILQIDNAKLAADDFRTKYETELSLRQLVEADINGLRRILDELTLCKADLEAQVESLKEELLCLKRNHEEEVNALRSQLGDRLNVEVDAAPPVDLNKILDDMRCQYETLVENNRRDVEAWFNTQTEELNQQVVSSSEQLQCCQTEIIELRRTVNSLEIELQAQQSMRNSLESTLAETEARYSSQLGQMQCLITNVESQLAEIRCDLERQNHEYQVLLDVKARLESEIATYRRLLDGEDCKLPAHPCSTECKPAVRVPYIPSTTCTPAGPCTPAGPCTPAPQVSTQIRTITEEIRDGRVISSREHVVPRAM", "length": 473 }, "evidence": [ { "id": "F1MI98", "url": "https://omabrowser.org/oma/group/F1MI98/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G3I8F4-1", "protein_name": "Keratin, type I cuticular Ha6", "gene_name": "LOC100758686", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATQICTPTFSTGSAKGLCGTVGSFSRMSSIHSMGSYRAPSLVGTVGSMPSFRTGFSGLGGCLPGSYLSSGCHSSGFAGSGGWFCEGTFNGNEKATMQVLNDRLANYLEKVRQLEQENASLECRIREWYECQVPYICPDYQSYFKTAEDLQQKILLTKSENARLVLQIDNAKLAADDFRTKYETELSLRQLVEADINGLRRILDELTLCKADLEAQVESLKEELLCLKKNHEEEVNVLRSQLGDRLNVEVDAAPPVDLNKILDDMRCQYETLVENNRRDVEAWFNTQTEELNQQVLSSSEQLQCCQTEIIELRRTVNALEIELQAQHSMRNSLESTLAETEARYGSQLGQMQCLITNVESQLTEIRCDLERQNHEYQVLLDVKARLESEIATYRHLLEGEDCKLPAHPCSTECKPAVRVPYISSTPCTLAGPCTPAPQVSTQIRTITEEIRDGRVVSSREHVVPRAL", "length": 467 }, "evidence": [ { "id": "F1MI98", "url": "https://omabrowser.org/oma/group/F1MI98/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O76013-1", "protein_name": "Keratin, type I cuticular Ha6", "gene_name": "KRT36", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATQTCTPTFSTGSIKGLCGTAGGISRVSSIRSVGSCRVPSLAGAAGYISSARSGLSGLGSCLPGSYLSSECHTSGFVGSGGWFCEGSFNGSEKETMQFLNDRLANYLEKVRQLERENAELESRIQEWYEFQIPYICPDYQSYFKTIEDFQQKILLTKSENARLVLQIDNAKLAADDFRTKYETELSLRQLVEADINGLRRILDELTLCKADLEAQVESLKEELMCLKKNHEEEVSVLRCQLGDRLNVEVDAAPPVDLNKILEDMRCQYEALVENNRRDVEAWFNTQTEELNQQVVSSSEQLQCCQTEIIELRRTVNALEIELQAQHSMRNSLESTLAETEARYSSQLAQMQCLISNVEAQLSEIRCDLERQNQEYQVLLDVKARLEGEIATYRHLLEGEDCKLPPQPCATACKPVIRVPSVPPVPCVPSVPCTPAPQVGTQIRTITEEIRDGKVISSREHVQSRPL", "length": 467 }, "evidence": [ { "id": "F1MI98", "url": "https://omabrowser.org/oma/group/F1MI98/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "F1MI98", "url": "https://www.uniprot.org/uniprotkb/F1MI98" } ], "pmid": "" }, { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "F1MI98", "url": "https://www.uniprot.org/uniprotkb/F1MI98" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "epithelial cell differentiation", "id": "GO:0030855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030855", "evidence": [ { "database": "UniProtKB", "id": "F1MI98", "url": "https://www.uniprot.org/uniprotkb/F1MI98" } ], "pmid": "" }, { "name": "intermediate filament organization", "id": "GO:0045109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045109", "evidence": [ { "database": "UniProtKB", "id": "F1MI98", "url": "https://www.uniprot.org/uniprotkb/F1MI98" } ], "pmid": "" }, { "name": "morphogenesis of an epithelium", "id": "GO:0002009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002009", "evidence": [ { "database": "UniProtKB", "id": "F1MI98", "url": "https://www.uniprot.org/uniprotkb/F1MI98" } ], "pmid": "" }, { "name": "regulation of keratinocyte differentiation", "id": "GO:0045616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045616", "evidence": [ { "database": "UniProtKB", "id": "F1MI98", "url": "https://www.uniprot.org/uniprotkb/F1MI98" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural constituent of skin epidermis", "id": "GO:0030280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030280", "evidence": [ { "database": "UniProtKB", "id": "F1MI98", "url": "https://www.uniprot.org/uniprotkb/F1MI98" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MI98-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 456, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MI98-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MI98" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI98" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 90, "end_pos": 401, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", 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}, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGZ5-1", "uniprot_ac": "F1MGZ5", "uniprot_id": "F1MGZ5_BOVIN", "mass": { "chemical_mass": 100269.0, "monoisotopic_mass": 100269.0 }, "refseq": { "ac": "NP_001193105", "name": "calcium-activated chloride channel regulator 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193105" }, "gene_names": [ { "name": "CLCA1", "type": "recommended", "evidence": [ { "id": "F1MGZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5" } ] }, { "name": "CLCA1", "type": "synonym", "evidence": [ { "id": "NP_001193105", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193105" } ] } ], "protein_names": [ { "name": "Calcium-activated chloride channel regulator 1", "type": "recommended", "evidence": [ { "id": "F1MGZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5/entry#names_and_taxonomy" } ] }, { "name": "CLCA family member 1, chloride channel regulator", "type": "synonym", "evidence": [ { "id": "NP_001193105", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193105" } ] }, { "name": "calcium-activated chloride channel regulator 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001193105", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193105" } ] }, { "name": "chloride channel regulator 1", "type": "synonym", "evidence": [ { "id": "NP_001193105", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193105" } ] }, { "name": "chloride channel, calcium activated, family member 1", "type": "synonym", "evidence": [ { "id": "NP_001193105", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193105" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MGZ5", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CLCA1", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5", "locus": { "chromosome": "3", "start_pos": 57558897, "end_pos": 57592968, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008161", "url": "https://www.ensembl.org/id/ENSBTAG00000008161" } ] } } ], "crossref": [ { "id": "F1MGZ5", "url": "https://alphafold.ebi.ac.uk/entry/F1MGZ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008161", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008161", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00198", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00198", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507643", "url": "https://www.ncbi.nlm.nih.gov/gene/507643", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004727", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004727", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013642", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013642", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507643", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507643", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MQNQKCN", "url": "https://omabrowser.org/oma/group/MQNQKCN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LF34", "url": "https://www.orthodb.org/?gene=A0A3Q1LF34", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MGZ5", "url": "https://www.orthodb.org/?gene=F1MGZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10579", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10579", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10579:SF52", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10579:SF52", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08434", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08434", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13519", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13519", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2672351", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193105", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LF34", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LF34-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF34-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGZ5", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGZ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSFKNSVFILVLHLLEGALSDSLIQLNNNGYEGIVIAIDPNVPEDETLIQHIKDMVTDASPYLFEATEKRFYFKNVAILIPENWKTKPEYVKPKLETYKNADVLVAEPNPTGNDGPYTEQMGGCGEKGDRIYLTPDFLAGKKSRQYGPQGRAFVHEWAHLRWGVFNEYNNDQKFYLSNKRRKPVVCSEGFTGETVIQKCQGGSCVTQPCKLDRKTGLYEEGCEFIPHKDQREKASIMYSQSIDTVVEFCTEKNHNREAPNEQNKKCNHRSTWEVIQDSEDFKTTTPMTTQPPSPTFSLLQIGQRIVCLVLDKSGSMTIGNRLKRLNQAGKLFLLQTVEQGSWVGMVTFDSAAYVQSELVQINSATERDTLTKSLPTTASGGTSICSGLRSAFTVIKKKYPTDGAEIILLTDGEDNTISACFDEVKQSGAIIHTVALGPSAAQELEQMSKMTGGLQTYASDQVQNNGLVDAFAALSSGNKAVSQRSIQLESRGLTLQNSQWMNGTVTVDSTVGKDTLFLITWTTDLPQILLWDPSGNKQDGFIVDKNTKMAYLQIPDIAKIGVWKYSLQASSQTLTLTVTSRASSATLPPVTVTSKMNKDTGKFPSPMVVYVKIHQGTKPILRSKVTALIESVDGKTVTLELLDNGAGADATKDDGIYSRYFTAYDTNGRYSAKVWALGGVNTASQNASPQRNGAMYIPGWIENGEVKWNPPRPEINKDQGKQVCFSRTSSGGSFVATDVPKAPIPDLFPPCKITDLKAKIEGDNLINLTWTAPGDDYDHGRADKYIIRISTNILELRDKFNESLQVNTTDLIPNEANSEEVFVFKPETITFTNGTDLFIAIQAVDEVSLKSEISNIAQVSLFIPPEIPPEKPSPSLPCPDISINSTIPGIHILKIMWKWLGELQISLG", "length": 909, "header": "tr|F1MGZ5-1|F1MGZ5_BOVIN Isoform 1 of Calcium-activated chloride channel regulator 1 OS=Bos taurus OX=9913 GN=CLCA1 PE=1 SV=3 CANONICAL=F1MGZ5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LF34-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF34/entry", "sequence": { "sequence": "MGSFKNSVFILVLHLLEGALSDSLIQLNNNGYEGIVIAIDPNVPEDETLIQHIKDMVTDASPYLFFYQNILESNKIADVLVAEPNPTGNDGPYTEQMGGCGEKGDRIYLTPDFLAGKKSRQYGPQGRAFVHEWAHLRWGVFNEYNNDQKFYLSNKRRKPVVCSEGFTGETVIQKCQGGSCVTQPCKLDRKTGLYEEGCEFIPHKDQREKASIMYSQSIDTVVEFCTEKNHNREAPNEQNKKCNHRSTWEVIQDSEDFKTTTPMTTQPPSPTFSLLQIGQRIVCLVLDKSGSMTIGNRLKRLNQAGKLFLLQTVEQGSWVGMVTFDSAAYVQSELVQINSATERDTLTKSLPTTASGGTSICSGLRSAFTVIKKKYPTDGAEIILLTDGEDNTISACFDEVKQSGAIIHTVALGPSAAQELEQMSKMTGGLQTYASDQVQNNGLVDAFAALSSGNKAVSQRSIQLESRGLTLQNSQWMNGTVTVDSTVGKDTLFLITWTTDLPQILLWDPSGNKQDGFIVDKNTKMAYLQIPDIAKIGVWKYSLQASSQTLTLTVTSRASSATLPPVTVTSKMNKDTGKFPSPMVVYVKIHQGTKPILRSKVTALIESVDGKTVTLELLDNGAGADATKDDGIYSRYFTAYDTNGRYSAKVWALGGVNTASQNASPQRNGAMYIPGWIENGEVKWNPPRPEINKDQGKQVCFSRTSSGGSFVATDVPKAPIPDLFPPCKITDLKAKIEGDNLINLTWTAPGDDYDHGRADKYIIRISTNILELRDKFNESLQVNTTDLIPNEANSEEVFVFKPETITFTNGTDLFIAIQAVDEVSLKSEISNIAQVSLFIPPEIPPEKPSPSLPCPDISINSTIPGIHILKIMWKWLGELQISLG", "length": 884, "header": "tr|A0A3Q1LF34-1|F1MGZ5_BOVIN Computationally mapped isoform of Calcium-activated chloride channel regulator 1 OS=Bos taurus OX=9913 GN=CLCA1 PE=1 SV=1 CANONICAL=F1MGZ5-1" }, "locus": { "chromosome": "3", "start_pos": 57592917, "end_pos": 57559042, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067600.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067600.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056670.1", "url": "https://www.ensembl.org/id/ENSBTAP00000056670.1" } ] } }, { "isoform_ac": "F1MGZ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5/entry", "sequence": { "sequence": "MGSFKNSVFILVLHLLEGALSDSLIQLNNNGYEGIVIAIDPNVPEDETLIQHIKDMVTDASPYLFEATEKRFYFKNVAILIPENWKTKPEYVKPKLETYKNADVLVAEPNPTGNDGPYTEQMGGCGEKGDRIYLTPDFLAGKKSRQYGPQGRAFVHEWAHLRWGVFNEYNNDQKFYLSNKRRKPVVCSEGFTGETVIQKCQGGSCVTQPCKLDRKTGLYEEGCEFIPHKDQREKASIMYSQSIDTVVEFCTEKNHNREAPNEQNKKCNHRSTWEVIQDSEDFKTTTPMTTQPPSPTFSLLQIGQRIVCLVLDKSGSMTIGNRLKRLNQAGKLFLLQTVEQGSWVGMVTFDSAAYVQSELVQINSATERDTLTKSLPTTASGGTSICSGLRSAFTVIKKKYPTDGAEIILLTDGEDNTISACFDEVKQSGAIIHTVALGPSAAQELEQMSKMTGGLQTYASDQVQNNGLVDAFAALSSGNKAVSQRSIQLESRGLTLQNSQWMNGTVTVDSTVGKDTLFLITWTTDLPQILLWDPSGNKQDGFIVDKNTKMAYLQIPDIAKIGVWKYSLQASSQTLTLTVTSRASSATLPPVTVTSKMNKDTGKFPSPMVVYVKIHQGTKPILRSKVTALIESVDGKTVTLELLDNGAGADATKDDGIYSRYFTAYDTNGRYSAKVWALGGVNTASQNASPQRNGAMYIPGWIENGEVKWNPPRPEINKDQGKQVCFSRTSSGGSFVATDVPKAPIPDLFPPCKITDLKAKIEGDNLINLTWTAPGDDYDHGRADKYIIRISTNILELRDKFNESLQVNTTDLIPNEANSEEVFVFKPETITFTNGTDLFIAIQAVDEVSLKSEISNIAQVSLFIPPEIPPEKPSPSLPCPDISINSTIPGIHILKIMWKWLGELQISLG", "length": 909, "header": "tr|F1MGZ5-1|F1MGZ5_BOVIN Isoform 1 of Calcium-activated chloride channel regulator 1 OS=Bos taurus OX=9913 GN=CLCA1 PE=1 SV=3 CANONICAL=F1MGZ5-1" }, "locus": { "chromosome": "3", "start_pos": 57592917, "end_pos": 57559042, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010730.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010730.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010730.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010730.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507643", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507643", "resource": "KEGG Pathway" }, { "id": "R-BTA-2672351", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "resource": "Reactome", "description": "Stimuli-sensing channels" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JWX9-1", "protein_name": "Calcium-activated chloride channel regulator 1", "gene_name": "Clca1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGSLKSPVFLLVLYLLEGVLSNSLIQLNNNGYEGIVIAIDHDVPEDEALIQRIKDMVTQASPYLFEATGKRFYFKNVAILIPENWNTKPEYKRPKLETLKNADVLVSTMSPIGNDEPYTEHIGACGERGIRIHLTPDFLAGKKQTEYGPQDRTFVHEWAHFRWGVFDEYNNNEKFYLSNGKPQAVRCSATITGKHVVRRCQGGSCVTNGKCVIDRVTGLYKDNCVFIPDKNQREKASIMFNQNINSVVEFCTEKNHNKEAPNAQNQRCNLRSTWEVIQESEDFKQTTPMTAQPPAPTFSLLQTRQRIVCLVLDKSGSMQSDNRLNRMNQASRLFLLQTVEQGSWVGMVTFDSTAYVQSELTQLNSGADRDLLIKRLPTVASGGTSICSGLQAAFTSIKKKYPTDGAEIVLLTDGEDNTISSCFDLVKNSGAIIHTVALGPSAAKELEQLSKMTGGLQTYSSDQIQNNGLVDAFAALSSGNAAISQHSIQLESRGVNLQNKQWMNGSVIVDSTVGKDTLFLVTWTTNSPSIFIWDPSGVQQSGFVLDTNTKVAYLQVPGIAKVGFWKYSIQASSQTLTLTVTSRAASATLPPITVTPVVNKNTGKFPSPVTVYASIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKNDGVYSRFFTAFDANGRYSIKIWALGGVTADRQRMAPQRNGVMYIDGWIEDDGEIKMNPPHPETGNVQDSQVCFSRTSSGGSFVATNVPAAPIPDLFPPCQITDLKASIQGQNLVNLTWTAPGDDYDHGRASSYIIRISTSIVDLRNNFSTSLEVNTTDLIPKEASSEEMFEFELDNSFGNGTDVFIAIQAVDKSNLKSEISNIARVSLFIPAQEPPEDSTPSYPEVSINSTIPGIHVLNIVWKWLGEMHVTLGLH", "length": 910 }, "evidence": [ { "id": "F1MGZ5", "url": "https://omabrowser.org/oma/group/F1MGZ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A8K7I4-1", "protein_name": "Calcium-activated chloride channel regulator 1", "gene_name": "CLCA1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGPFKSSVFILILHLLEGALSNSLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQASLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAESTPPGNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKKCQGGSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMTTQPPNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELIQINSGSDRDTLAKRLPAAASGGTSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLIDAFGALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIAKVGTWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKDDGVYSRYFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVASDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKPENITFENGTDLFIAIQAVDKVDLKSEISNIARVSLFIPPQTPPETPSPDETSAPCPNIHINSTIPGIHILKIMWKWIGELQLSIA", "length": 914 }, "evidence": [ { "id": "F1MGZ5", "url": "https://omabrowser.org/oma/group/F1MGZ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D7Z6-1", "protein_name": "Calcium-activated chloride channel regulator 1", "gene_name": "Clca1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESLKSPVFLLILHLLEGVLSESLIQLNNNGYEGIVIAIDHDVPEDEALIQHIKDMVTQASPYLFEATGKRFYFKNVAILIPESWKAKPEYTRPKLETFKNADVLVSTTSPLGNDEPYTEHIGACGEKGIRIHLTPDFLAGKKLTQYGPQDRTFVHEWAHFRWGVFNEYNNDEKFYLSKGKPQAVRCSAAITGKNQVRRCQGGSCITNGKCVIDRVTGLYKDNCVFVPDPHQNEKASIMFNQNINSVVEFCTEKNHNQEAPNDQNQRCNLRSTWEVIQESEDFKQTTPMTAQPPAPTFSLLQIGQRIVCLVLDKSGSMLNDDRLNRMNQASRLFLLQTVEQGSWVGMVTFDSAAYVQSELKQLNSGADRDLLIKHLPTVSAGGTSICSGLRTAFTVIKKKYPTDGSEIVLLTDGEDNTISSCFDLVKQSGAIIHTVALGPAAAKELEQLSKMTGGLQTYSSDQVQNNGLVDAFAALSSGNAAIAQHSIQLESRGVNLQNNQWMNGSVIVDSSVGKDTLFLITWTTHPPTIFIWDPSGVEQNGFILDTTTKVAYLQVPGTAKVGFWKYSIQASSQTLTLTVTSRAASATLPPITVTPVVNKNTGKFPSPVTVYASIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKNDGVYSRFFTAFDANGRYSVKIWALGGVTSDRQRAAPPKNRAMYIDGWIEDGEVRMNPPRPETSYVQDKQLCFSRTSSGGSFVATNVPAAAPIPDLFPPCQITDLKASIQGQNLVNLTWTAPGDDYDHGRASNYIIRMSTSIVDLRDHFNTSLQVNTTGLIPKEASSEEIFEFELGGNTFGNGTDIFIAIQAVDKSNLKSEISNIARVSVFIPAQEPPIPEDSTPPCPDISINSTIPGIHVLKIMWKWLGEMQVTLGLH", "length": 913 }, "evidence": [ { "id": "F1MGZ5", "url": "https://omabrowser.org/oma/group/F1MGZ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ5", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ5", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5" } ], "pmid": "" }, { "name": "secretory granule", "id": "GO:0030141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030141", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ5", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5" } ], "pmid": "" }, { "name": "microvillus", "id": "GO:0005902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005902", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ5", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ5", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5" } ], "pmid": "" }, { "name": "calcium ion transport", "id": "GO:0006816", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006816", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ5", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metallopeptidase activity", "id": "GO:0008237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008237", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ5", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ5", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5" } ], "pmid": "" }, { "name": "intracellularly calcium-gated chloride channel activity", "id": "GO:0005229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005229", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ5", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 503, "end_pos": 505, "annotation": "n_glycosylation_sequon" }, { "start_pos": 687, "end_pos": 689, "annotation": "n_glycosylation_sequon" }, { "start_pos": 768, "end_pos": 770, "annotation": "n_glycosylation_sequon" }, { "start_pos": 802, "end_pos": 804, "annotation": "n_glycosylation_sequon" }, { "start_pos": 808, "end_pos": 810, "annotation": "n_glycosylation_sequon" }, { "start_pos": 834, "end_pos": 836, "annotation": "n_glycosylation_sequon" }, { "start_pos": 885, "end_pos": 887, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MGZ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 909, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MGZ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MGZ5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MGZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGZ5" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 306, "end_pos": 475, "start_aa": "Ile", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 503, "end_pos": 505 }, { "start_pos": 687, "end_pos": 689 }, { "start_pos": 768, "end_pos": 770 }, { "start_pos": 802, "end_pos": 804 }, { "start_pos": 808, "end_pos": 810 }, { "start_pos": 834, "end_pos": 836 }, { "start_pos": 885, "end_pos": 887 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGV0-1", "uniprot_ac": "F1MGV0", "uniprot_id": "F1MGV0_BOVIN", "mass": { "chemical_mass": 70771.0, "monoisotopic_mass": 70771.0 }, "refseq": {}, "gene_names": [ { "name": "MBTD1", "type": "recommended", "evidence": [ { "id": "F1MGV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGV0" } ] } ], "protein_names": [ { "name": "Mbt domain containing 1", "type": "synonym", "evidence": [ { "id": "F1MGV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGV0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MGV0", "url": "https://www.uniprot.org/uniprotkb/F1MGV0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MBTD1", "url": "https://www.uniprot.org/uniprotkb/F1MGV0", "locus": { "chromosome": "19", "start_pos": 35578545, "end_pos": 35518643, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009407", "url": "https://www.ensembl.org/id/ENSBTAG00000009407" } ] } } ], "crossref": [ { "id": "F1MGV0", "url": "https://alphafold.ebi.ac.uk/entry/F1MGV0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009407", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009407", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20120", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20120", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20123", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20123", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20126", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20126", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20129", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20129", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR004092", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004092", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012313", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012313", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038603", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038603", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJT2", "url": "https://www.orthodb.org/?gene=A0A3Q1LJT2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MGV0", "url": "https://www.orthodb.org/?gene=F1MGV0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12247", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12247", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12247:SF79", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12247:SF79", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02820", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02820", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21319", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21319", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LJT2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJT2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJT2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGV0", "url": "https://www.uniprot.org/uniprotkb/F1MGV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGV0-1", "url": "https://www.uniprot.org/uniprotkb/F1MGV0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFDGYDSCSEDTSSSSSSEESEEEAAPLPSSLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKASILARLQVTGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKSAAVSTEGFNWGNYINSNSFIAAPVTCFKHAPMGTCWGDISENVRVEVPNTDCSLPTKVFWIAGIVKLAGYNALLRYEGFENDSGLDFWYSICGSDIHPVGWCAASGKPLVPPRTIQHKYTNWKAFLVKRLTGAKTLPPDFSQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRFKRSDITKKQDGHFDTPPHLFAKVKEVDQSGEWFKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLPFKWFDYLRETGSIAAPVKLFNKDVPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPPASQSSRESQSGSSKQKKKTKSQQYKGHKKMTTLQLKEELIDGEDYSFLQGASDQESNGSANFYIKQEP", "length": 631, "header": "tr|F1MGV0-1|F1MGV0_BOVIN Isoform 1 of Mbt domain containing 1 OS=Bos taurus OX=9913 GN=MBTD1 PE=4 SV=4 CANONICAL=F1MGV0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LJT2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJT2/entry", "sequence": { "sequence": "MFDGYDSCSEDTSSSSSSEESEEEAAPLPSSLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKASILARLQVTGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKSAVSTEGFNWGNYINSNSFIAAPVTCFKHAPMGTCWGDISENVRVEVPNTDCSLPTKVFWIAGIVKLAGYNALLRYEGFENDSGLDFWYSICGSDIHPVGWCAASGKPLVPPRTIQHKYTNWKAFLVKRLTGAKTLPPDFSQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRFKRSDITKKQDGHFDTPPHLFAKVKEVDQSGEWFKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLPFKWFDYLRETGSIAAPVKLFNKDVPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPPASQSSRESQSGSSKQKKKTKSQQYKGHKKKGALLPLKMLTSMTSVATKKPKPH", "length": 615, "header": "tr|A0A3Q1LJT2-1|F1MGV0_BOVIN Computationally mapped isoform of Mbt domain containing 1 OS=Bos taurus OX=9913 GN=MBTD1 PE=4 SV=2 CANONICAL=F1MGV0-1" }, "locus": { "chromosome": "19", "start_pos": 35576451, "end_pos": 35540883, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075446.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075446.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056824.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056824.2" } ] } }, { "isoform_ac": "F1MGV0-1", "url": "https://www.uniprot.org/uniprotkb/F1MGV0/entry", "sequence": { "sequence": "MFDGYDSCSEDTSSSSSSEESEEEAAPLPSSLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKASILARLQVTGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKSAAVSTEGFNWGNYINSNSFIAAPVTCFKHAPMGTCWGDISENVRVEVPNTDCSLPTKVFWIAGIVKLAGYNALLRYEGFENDSGLDFWYSICGSDIHPVGWCAASGKPLVPPRTIQHKYTNWKAFLVKRLTGAKTLPPDFSQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRFKRSDITKKQDGHFDTPPHLFAKVKEVDQSGEWFKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLPFKWFDYLRETGSIAAPVKLFNKDVPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPPASQSSRESQSGSSKQKKKTKSQQYKGHKKMTTLQLKEELIDGEDYSFLQGASDQESNGSANFYIKQEP", "length": 631, "header": "tr|F1MGV0-1|F1MGV0_BOVIN Isoform 1 of Mbt domain containing 1 OS=Bos taurus OX=9913 GN=MBTD1 PE=4 SV=4 CANONICAL=F1MGV0-1" }, "locus": { "chromosome": "19", "start_pos": 35577541, "end_pos": 35540883, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034943.6", "url": "https://www.ensembl.org/id/ENSBTAT00000034943.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034827.5", "url": "https://www.ensembl.org/id/ENSBTAP00000034827.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "F1MGV0", "url": "https://www.uniprot.org/uniprotkb/F1MGV0" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MGV0", "url": "https://www.uniprot.org/uniprotkb/F1MGV0" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "F1MGV0", "url": "https://www.uniprot.org/uniprotkb/F1MGV0" } ], "pmid": "" }, { "name": "NuA4 histone acetyltransferase complex binding", "id": "GO:0062060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062060", "evidence": [ { "database": "UniProtKB", "id": "F1MGV0", "url": "https://www.uniprot.org/uniprotkb/F1MGV0" } ], "pmid": "" }, { "name": "histone H4K20me2 reader activity", "id": "GO:0140005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140005", "evidence": [ { "database": "UniProtKB", "id": "F1MGV0", "url": "https://www.uniprot.org/uniprotkb/F1MGV0" } ], "pmid": "" }, { "name": "histone H4K20me1 reader activity", "id": "GO:0140117", "url": 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"" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1MGV0", "url": "https://www.uniprot.org/uniprotkb/F1MGV0" } ], "pmid": "" }, { "name": "double-strand break repair via homologous recombination", "id": "GO:0000724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000724", "evidence": [ { "database": "UniProtKB", "id": "F1MGV0", "url": "https://www.uniprot.org/uniprotkb/F1MGV0" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "F1MGV0", "url": "https://www.uniprot.org/uniprotkb/F1MGV0" } ], "pmid": "" }, { "name": "positive regulation of double-strand break repair via homologous recombination", "id": "GO:1905168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905168", "evidence": [ { "database": "UniProtKB", "id": "F1MGV0", "url": "https://www.uniprot.org/uniprotkb/F1MGV0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 620, "end_pos": 622, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MGV0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 631, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MGV0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MGV0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MGV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGV0" }, { "id": "PS51024", "database": "PROSITE", 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] }, { "name": "3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit", "type": "synonym", "evidence": [ { "id": "E1BPP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP6/entry#names_and_taxonomy" } ] }, { "name": "3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta", "type": "synonym", "evidence": [ { "id": "E1BPP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP6/entry#names_and_taxonomy" } ] }, { "name": "6.4.1.4", "type": "synonym", "evidence": [ { "id": "E1BPP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.", "evidence": [ { "database": "UniProtKB", "id": "E1BPP6", "url": 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"url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044160", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011762", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034733", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034733", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BPP6", "url": "https://www.orthodb.org/?gene=E1BPP6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22855", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22855", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22855:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22855:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01039", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01039", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-196780", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196780", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-70895", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70895", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "13589", "url": "https://www.rhea-db.org/rhea/13589", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LKL3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKL3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKL3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPP6", "url": "https://www.uniprot.org/uniprotkb/E1BPP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPP6-1", "url": "https://www.uniprot.org/uniprotkb/E1BPP6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1Q0", "url": "https://www.uniprot.org/uniprotkb/G3N1Q0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N1Q0-1", "url": "https://www.uniprot.org/uniprotkb/G3N1Q0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWAALRLALRPCARAAAPALRSYHGDSVATLGTQPDSSSAIYQENYEQMKALVNQLHERAQSIRLGGGEKARARHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYGDEEVPAGGVITGIGRVSGVECMIVANDATVKGGSYYPVTVKKHLRAQEIAMQNRLPCIYLVDSGGANLPRQAEVFPDRDHFGRIFYNQAVMSSKSITQIAVVMGSCTAGGAYVPAMADENIIVRKQGTIFLGGPPLVRTCLFVSFLVKAATGEEVSAEDLGGADLHCRKSGVSDYYALDDNHALHLARKIVRSLNYQKKMDVTIEPSEDPLFPADELYGIVGANLKRNFDVREVIARIVDGSRFNEFKALYGDTLVTGFARIFGYPIGIVGNNGVLFSESAKKGAHFIQLCCQRNIPLLFLQNITGFMVGRDYEAEGIAKDGAKMVTAVACANVPKITVIIGGSYGAGNYGMCGRAYSPRFLYLWPNARISVMGGEQAANVLATVAKDQRAREGKQFSSADEAALKEPIIKRFEEEGNPYYSSARLWDDGIIDPVDTRLVLGLSLSAALNAPIHKTNFGILRM", "length": 573, "header": "tr|E1BPP6-1|E1BPP6_BOVIN Isoform 1 of Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Bos taurus OX=9913 GN=MCCC2 PE=3 SV=4 CANONICAL=E1BPP6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKL3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKL3/entry", "sequence": { "sequence": "MWAALRLALRPCARAAAPALRSYHGDSVATLGTQPDSSSAIYQENYEQMKALVNQLHERAQSIRLGGGEKARARHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYGDEEVPAGGVITGIGRVSGVECMIVANDATVKGGSYYPVTVKKHLRAQEIAMQNRLPCIYLVDSGGANLPRQAEVFPDRDHFGRIFYNQAVMSSKSITQVKAATGEEVSAEDLGGADLHCRKSGVSDYYALDDNHALHLARKIVRSLNYQKKMDVTIEPSEDPLFPADELYGIVGANLKRNFDVREVIARIVDGSRFNEFKALYGDTLVTGFARIFGYPIGIVGNNGVLFSESAKKGAHFIQLCCQRNIPLLFLQNITGFMVGRDYEAEGIAKDGAKMVTAVACANVPKITVIIGGSYGAGNYGMCGRAYSPRFLYLWPNARISVMGGEQAANVLATVAKDQRAREGKQFSSADEAALKEPIIKRFEEEGNPYYSSARLWDDGIIDPVDTRLVLGLSLSAALNAPIHKTNFGILRM", "length": 525, "header": "tr|A0A3Q1LKL3-1|E1BPP6_BOVIN Computationally mapped isoform of Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Bos taurus OX=9913 GN=MCCC2 PE=3 SV=2 CANONICAL=E1BPP6-1" }, "locus": { "chromosome": "20", "start_pos": 9992861, "end_pos": 9917224, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077645.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077645.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057245.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057245.2" } ] } }, { "isoform_ac": "E1BPP6-1", "url": "https://www.uniprot.org/uniprotkb/E1BPP6/entry", "sequence": { "sequence": "MWAALRLALRPCARAAAPALRSYHGDSVATLGTQPDSSSAIYQENYEQMKALVNQLHERAQSIRLGGGEKARARHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYGDEEVPAGGVITGIGRVSGVECMIVANDATVKGGSYYPVTVKKHLRAQEIAMQNRLPCIYLVDSGGANLPRQAEVFPDRDHFGRIFYNQAVMSSKSITQIAVVMGSCTAGGAYVPAMADENIIVRKQGTIFLGGPPLVRTCLFVSFLVKAATGEEVSAEDLGGADLHCRKSGVSDYYALDDNHALHLARKIVRSLNYQKKMDVTIEPSEDPLFPADELYGIVGANLKRNFDVREVIARIVDGSRFNEFKALYGDTLVTGFARIFGYPIGIVGNNGVLFSESAKKGAHFIQLCCQRNIPLLFLQNITGFMVGRDYEAEGIAKDGAKMVTAVACANVPKITVIIGGSYGAGNYGMCGRAYSPRFLYLWPNARISVMGGEQAANVLATVAKDQRAREGKQFSSADEAALKEPIIKRFEEEGNPYYSSARLWDDGIIDPVDTRLVLGLSLSAALNAPIHKTNFGILRM", "length": 573, "header": "tr|E1BPP6-1|E1BPP6_BOVIN Isoform 1 of Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Bos taurus OX=9913 GN=MCCC2 PE=3 SV=4 CANONICAL=E1BPP6-1" }, "locus": { "chromosome": "20", "start_pos": 9992861, "end_pos": 9917224, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061526.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061526.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053392.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053392.4" } ] } }, { "isoform_ac": "G3N1Q0-1", "url": "https://www.uniprot.org/uniprotkb/G3N1Q0/entry", "sequence": { "sequence": "MWAALRLALRPCARAAAPALRSYHGDSVATLGTQPDSSSAIYQENYEQMKALVNQLHERAQSIRLGGGEKARARHISRGKLLPRERIDNLIDPGVECMIVANDATVKGGSYYPVTVKKHLRAQEIAMQNRLPCIYLVDSGGANLPRQAEVFPDRDHFGRIFYNQAVMSSKSITQVKAATGEEVSAEDLGGADLHCRKSGVSDYYALDDNHALHLARKIVRSLNYQKKMDVTIEPSEDPLFPADELYGIVGANLKRNFDVREVIARIVDGSRFNEFKALYGDTLVTGFARIFGYPIGIVGNNGVLFSESAKKGAHFIQLCCQRNIPLLFLQNITGFMVGRDYEAEGIAKDGAKMVTAVACANVPKITVIIGGSYGAGNYGMCGRAYSPRFLYLWPNARISVMGGEQAANVLATVAKDQRAREGKQFSSADEAALKEPIIKRFEEEGNPYYSSARLWDDGIIDPVDTRLVLGLSLSAALNAPIHKTNFGILRM", "length": 491, "header": "tr|G3N1Q0-1|E1BPP6_BOVIN Computationally mapped isoform of Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Bos taurus OX=9913 GN=MCCC2 PE=3 SV=3 CANONICAL=E1BPP6-1" }, "locus": { "chromosome": "20", "start_pos": 9992861, "end_pos": 9917224, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063028.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063028.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000055803.3", "url": "https://www.ensembl.org/id/ENSBTAP00000055803.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-196780", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196780", "resource": "Reactome", "description": "Biotin transport and metabolism" }, { "id": "R-BTA-70895", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70895", "resource": "Reactome", "description": "Branched-chain amino acid catabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "L-leucine catabolic process", "id": "GO:0006552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006552", "evidence": [ { "database": "UniProtKB", "id": "E1BPP6", "url": "https://www.uniprot.org/uniprotkb/E1BPP6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "methylcrotonoyl-CoA carboxylase activity", "id": "GO:0004485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004485", "evidence": [ { "database": "UniProtKB", "id": "E1BPP6", "url": "https://www.uniprot.org/uniprotkb/E1BPP6" } ], "pmid": "" }, { "name": "ligase activity", "id": "GO:0016874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016874", "evidence": [ { "database": "UniProtKB", "id": "E1BPP6", "url": "https://www.uniprot.org/uniprotkb/E1BPP6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BPP6", "url": "https://www.uniprot.org/uniprotkb/E1BPP6" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "E1BPP6", "url": "https://www.uniprot.org/uniprotkb/E1BPP6" } ], "pmid": "" }, { "name": "methylcrotonoyl-CoA carboxylase complex", "id": "GO:1905202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905202", "evidence": [ { "database": "UniProtKB", "id": "E1BPP6", "url": "https://www.uniprot.org/uniprotkb/E1BPP6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 413, "end_pos": 415, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13589", "name": "", "equation": "3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BPP6-1", "A0A3Q1LRD6-1" ], "evidence": [ { "id": "13589", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13589" } ] }, { "id": "R-BTA-2993799", "name": "HLCS biotinylates 6xMCCC1:6xMCCC2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LRD6-1", "E1BPP6-1" ], "evidence": [ { "id": "R-BTA-2993799", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2993799" } ] }, { "id": "R-BTA-3323111", "name": "Cytosolic carboxylases translocate to mitochondrial matrix", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LYL5-1", "Q2TBR0-1", "A0A3Q1LRD6-1", "Q29RK2-1", "E1BPP6-1" ], "evidence": [ { "id": "R-BTA-3323111", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3323111" } ] }, { "id": "R-BTA-508308", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate <=> beta-methylcrotonyl-CoA + ATP + HCO3- (MCCA)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-70772" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LRD6-1", "E1BPP6-1" ], "evidence": [ { "id": "R-BTA-508308", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-508308" } ] }, { "id": "R-BTA-70773", "name": "beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-70744" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LRD6-1", "E1BPP6-1" ], "evidence": [ { "id": "R-BTA-70773", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70773" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-70744", "participant_name": "bMC-CoA [mitochondrial matrix]", "crossref": [ { "id": "57344", "database": "ChEBI", "url": "" }, { "id": "ZINC000008551513", "database": "ZINC", "url": "" }, { "id": "C03069", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-70772", "participant_name": "bMG-CoA [mitochondrial matrix]", "crossref": [ { "id": "57346", "database": "ChEBI", "url": "" }, { "id": "ZINC000096077648", "database": "ZINC", "url": "" }, { "id": "C03231", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LRD6", "gene_name": "MCCC1", "activity": [ { "ec_number": "6.4.1.4", "activity": "3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LRD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRD6" } ] }, { "ec_number": "6.4.1.4", "activity": "", "evidence": [ { "id": "A0A3Q1LRD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRD6" } ] } ] }, { "uniprot_ac": "A0A3Q1LYL5", "gene_name": "PCCA", "activity": [ { "ec_number": "6.4.1.3", "activity": "propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5" } ] }, { "ec_number": "6.4.1.3", "activity": "", "evidence": [ { "id": "A0A3Q1LYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYL5" } ] } ] }, { "uniprot_ac": "E1BPP6", "gene_name": "MCCC2", "activity": [ { "ec_number": "6.4.1.4", "activity": "3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP6" } ] }, { "ec_number": "6.4.1.4", "activity": "", "evidence": [ { "id": "E1BPP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP6" } ] } ] }, { "uniprot_ac": "Q29RK2", "gene_name": "PC", "activity": [ { "ec_number": "6.4.1.1", "activity": "hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+).", "evidence": [ { "id": "Q29RK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RK2" } ] }, { "ec_number": "6.4.1.1", "activity": "", "evidence": [ { "id": "Q29RK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RK2" } ] } ] }, { "uniprot_ac": "Q2TBR0", "gene_name": "PCCB", "activity": [ { "ec_number": "6.4.1.3", "activity": "propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+).", "evidence": [ { "id": "Q2TBR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBR0" } ] }, { "ec_number": "6.4.1.3", "activity": "", "evidence": [ { "id": "Q2TBR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBR0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPP6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 573, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPP6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPP6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP6" }, { "id": "PS50989", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50989" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CoA carboxyltransferase C-terminal", "eco_id": "ECO_0000259", "start_pos": 319, "end_pos": 565, "start_aa": "Asp", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BPP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP6" }, { "id": "PS50980", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50980" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CoA carboxyltransferase N-terminal", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 316, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.4.1.4", "ec_name": "3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+).", "evidence": [ { "id": "6.4.1.4", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.4" }, { "id": "6.4.1.4", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.4.1.4" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 413, "end_pos": 415 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"name": "ADGRE5", "type": "synonym", "evidence": [ { "id": "XP_005208660", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208660" } ] }, { "name": "CD97", "type": "synonym", "evidence": [ { "id": "XP_005208660", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208660" } ] } ], "protein_names": [ { "name": "Adhesion G protein-coupled receptor E5", "type": "recommended", "evidence": [ { "id": "F1MCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCN3/entry#names_and_taxonomy" } ] }, { "name": "Leukocyte antigen CD97", "type": "synonym", "evidence": [ { "id": "F1MCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCN3/entry#names_and_taxonomy" } ] }, { "name": "adhesion G protein-coupled receptor E5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005208660", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208660" } ] } ], "function": [ { "annotation": "Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M0R0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0R0#function" }, { "database": "UniProtKB", "id": "ARBA00055309", "url": "https://www.uniprot.org/uniprotkb/ARBA00055309#function" }, { "database": "UniProtKB", "id": "F1MCN3", "url": "https://www.uniprot.org/uniprotkb/F1MCN3#function" }, { "database": "UniProtKB", "id": "A0A3Q1MD72", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD72#function" }, { "database": "UniProtKB", "id": "A0A3Q1LKL7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKL7#function" }, { "database": "UniProtKB", "id": "F6R6T6", "url": "https://www.uniprot.org/uniprotkb/F6R6T6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MCN3", "url": "https://www.uniprot.org/uniprotkb/F1MCN3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADGRE5", "url": "https://www.uniprot.org/uniprotkb/F1MCN3", "locus": { "chromosome": "7", "start_pos": 11353569, "end_pos": 11371468, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021818", "url": "https://www.ensembl.org/id/ENSBTAG00000021818" } ] } } ], "crossref": [ { "id": "F1MCN3", "url": "https://alphafold.ebi.ac.uk/entry/F1MCN3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021818", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021818", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "338066", "url": "https://www.ncbi.nlm.nih.gov/gene/338066", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057244", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057244", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DKKICRD", "url": "https://omabrowser.org/oma/group/DKKICRD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LKL7", "url": "https://www.orthodb.org/?gene=A0A3Q1LKL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0R0", "url": "https://www.orthodb.org/?gene=A0A3Q1M0R0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MCN3", "url": "https://www.orthodb.org/?gene=F1MCN3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6R6T6", "url": "https://www.orthodb.org/?gene=F6R6T6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12011", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12011", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12011:SF348", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12011:SF348", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01825", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01825", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-373080", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373080", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005208660", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005208660", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKL7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0R0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0R0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0R0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0R0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MD72", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MD72-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCN3", "url": "https://www.uniprot.org/uniprotkb/F1MCN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCN3-1", "url": "https://www.uniprot.org/uniprotkb/F1MCN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R6T6", "url": "https://www.uniprot.org/uniprotkb/F6R6T6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R6T6-1", "url": "https://www.uniprot.org/uniprotkb/F6R6T6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGPHGGPFLLFHVLCFLLTLSEVGSQNSKACALPCPPNSSCVNGTACRCAPGFISFSGEIFTDPLESCDDINECGPPSPVDCGSSADCQNTEGGYYCTCSPGYEPVSGAMIFRNESENTCRDVDECQHRPRVCKGRSVCINTEGSYTCQCPPGLEFSPEDPRHCTDVNECTSGKKPCHSSTHCLNSVGSYECRCRPGWKPIAGSPNGPNNTVCEDVDECSSGQHQCHNSTVCFNTVGSYTCHCREGWEPKHGLKNKQKDTICKEISFPAWTAPPGIKSRSLSAFFERVQKMSRDFKPAMAKKSMQDLVGSVDDLLKNSGDLESLDQSSKHVTVTHLLSGLEQILRTLAKAMPKGSFTYRSLDNTELSLVVQEQGKGNVTVGQSHARMLLDWAVAAAAEESGPTVVGILSSQNMKKLLANASLKLDSEKLKETYKSPVRGAKVTLLSAVSSVFLSNTNTEKLDSNVSFAFALHEQPELKPRQELICAFWKKDSNGNGSWATTGCWKMGRGNGSITCQCSHLSSFAILMAHYDVEDPKLALITKVGLALSLACLLLCILTFLLVRPIQGSRTTVHLHLCICLFVGSAIFLAGIENEGGEVGTRCRLVAVLLHYCFLAAFCWMSLEGVELYFLVVRVFQGQGLRKLWLCLIGYGVPLIIVGISAGAYSKGYGREKFCWLNFEGGFLWSFVGPVTFIVLGNAIIFVITVWKLTQKFSEINPDIKKLKKARVLTITAIAQLFVLGCTWVFGLLLFDPESWVLSYIFSILNCLQGFFLFVLYCLLNKKVREEYRKWACMVAGNKYSEFATTTSGSGSSHNQTQALRPSESGM", "length": 827, "header": "tr|F1MCN3-1|F1MCN3_BOVIN Isoform 1 of Adhesion G protein-coupled receptor E5 OS=Bos taurus OX=9913 GN=ADGRE5 PE=3 SV=1 CANONICAL=F1MCN3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKL7/entry", "sequence": { "sequence": "MGGPHGGPFLLFHVLCFLLTLSEVGSQNSKACALPCPPNSSCVNGTACRCAPGFISFSGEIFTDPLESCDDINECGPPSPVDCGSSADCQNTEGGYYCTCSPGYEPVSGAMIFRNESENTCRDVDECQHRPRVCKGRSVCINTEGSYTCQCPPGLEFSPEDPRHCTDVDECSSGQHQCHNSTVCFNTVGSYTCHCREGWEPKHGLKNKQKDTICKEISFPAWTAPPGIKSRSLSAFFERVQKMSRDFKPAMAKKSMQDLVGSVDDLLKNSGDLESLDQSSKHVTVTHLLSGLEQILRTLAKAMPKGSFTYRSLDNTELSLVVQEQGKGNVTVGQSHARMLLDWAVAAAAEESGPTVVGILSSQNMKKLLANASLKLDSEKLKETYKSPVRGAKVTLLSAVSSVFLSNTNTEKLDSNVSFAFALHEQPELKPRQELICAFWKKDSNGNGSWATTGCWKMGRGNGSITCQCSHLSSFAILMAHYDVEDPKLALITKVGLALSLACLLLCILTFLLVRPIQGSRTTVHLHLCICLFVGSAIFLAGIENEGGEVGTRCRLVAVLLHYCFLAAFCWMSLEGVELYFLVVRVFQGQGLRKLWLCLIGYGVPLIIVGISAGAYSKGYGREKFCWLNFEGGFLWSFVGPVTFIVLGNAIIFVITVWKLTQKFSEINPDIKKLKKARVLTITAIAQLFVLGCTWVFGLLLFDPESWVLSYIFSILNCLQGFFLFVLYCLLNKKVREEYRKWACMVAGNKYSEFATTTSGSGSSHNQTQALRPSESGM", "length": 778, "header": "tr|A0A3Q1LKL7-1|F1MCN3_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor E5 OS=Bos taurus OX=9913 GN=ADGRE5 PE=3 SV=1 CANONICAL=F1MCN3-1" }, "locus": { "chromosome": "7", "start_pos": 11371416, "end_pos": 11354132, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081548.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081548.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057250.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057250.1" } ] } }, { "isoform_ac": "A0A3Q1M0R0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0R0/entry", "sequence": { "sequence": "MPRTHFLLEQQTETQSPSLGGAESPLFLVCVTLGTASALPLLCFLLTLSEVGSQNSKACALPCPPNSSCVNGTACRCAPGFISFSGEIFTDPLESCDDINECGPPSPVDCGSSADCQNTEGGYYCTCSPGYEPVSGAMIFRNESENTCRDVDECSSGQHQCHNSTVCFNTVGSYTCHCREGWEPKHGLKNKQKDTICKEISFPAWTAPPGIKSRSLSAFFERVQKMSRDFKPAMAKKSMQDLVGSVDDLLKNSGDLESLDQSSKHVTVTHLLSGLEQILRTLAKAMPKGSFTYRSLDNTELSLVVQEQGKGNVTVGQSHARMLLDWAVAAAAEESGPTVVGILSSQNMKKLLANASLKLDSEKLKETYKSPVRGAKVTLLSAVSSVFLSNTNTEKLDSNVSFAFALHEQPELKPRQELICAFWKKDSNGNGSWATTGCWKMGRGNGSITCQCSHLSSFAILMAHYDVEDPKLALITKVGLALSLACLLLCILTFLLVRPIQGSRTTVHLHLCICLFVGSAIFLAGIENEGGEVGTRCRLVAVLLHYCFLAAFCWMSLEGVELYFLVVRVFQGQGLRKLWLCLIGYGVPLIIVGISAGAYSKGYGREKFCWLNFEGGFLWSFVGPVTFIVLGNAIIFVITVWKLTQKFSEINPDIKKLKKARVLTITAIAQLFVLGCTWVFGLLLFDPESWVLSYIFSILNCLQGFFLFVLYCLLNKKVGCRPGCGRSWAPPPVLGPVLP", "length": 739, "header": "tr|A0A3Q1M0R0-1|F1MCN3_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor E5 OS=Bos taurus OX=9913 GN=ADGRE5 PE=3 SV=2 CANONICAL=F1MCN3-1" }, "locus": { "chromosome": "7", "start_pos": 11367100, "end_pos": 11354377, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081916.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081916.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066821.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066821.2" } ] } }, { "isoform_ac": "A0A3Q1MD72-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD72/entry", "sequence": { "sequence": "MLSLGPGSDSFLPFLLPYPSAHCPLLGLPGLLGSVLPPTAFSVLCFLLTLSEVGSQNSKACALPCPPNSSCVNGTACRCAPGFISFSGEIFTDPLESCDDINECGPPSPVDCGSSADCQNTEGGYYCTCSPGYEPVSGAMIFRNESENTCRDVDECSSGQHQCHNSTVCFNTVGSYTCHCREGWEPKHGLKNKQKDTICKEISFPAWTAPPGIKSRSLSAFFERVQKMSRDFKPAMAKKSMQDLVGSVDDLLKNSGDLESLDQSSKHVTVTHLLSGLEQILRTLAKAMPKGSFTYRSLDNTELSLVVQEQGKGNVTVGQSHARMLLDWAVAAAAEESGPTVVGILSSQNMKKLLANASLKLDSEKLKETYKSPVRGAKVTLLSAVSSVFLSNTNTEKLDSNVSFAFALHEQPELKPRQELICAFWKKDSNGNGSWATTGCWKMGRGNGSITCQCSHLSSFAILMAHYDVEDPKLALITKVGLALSLACLLLCILTFLLVRPIQGSRTTVHLHLCICLFVGSAIFLAGIENEGGEVGTRCRLVAVLLHYCFLAAFCWMSLEGVELYFLVVRVFQGQGLRKLWLCLIGYGVPLIIVGISAGAYSKGYGREKFCWLNFEGGFLWSFVGPVTFIVLGNAIIFVITVWKLTQKFSEINPDIKKLKKARVLTITAIAQLFVLGCTWVFGLLLFDPESWVLSYIFSILNCLQGFFLFVLYCLLNKKVREEYRKWACMVAGNKYSEFATTTSGSGSSHNQTQALRPSESGM", "length": 763, "header": "tr|A0A3Q1MD72-1|F1MCN3_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor E5 OS=Bos taurus OX=9913 GN=ADGRE5 PE=3 SV=1 CANONICAL=F1MCN3-1" }, "locus": { "chromosome": "7", "start_pos": 11368992, "end_pos": 11354132, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076703.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076703.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068863.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068863.2" } ] } }, { "isoform_ac": "F1MCN3-1", "url": "https://www.uniprot.org/uniprotkb/F1MCN3/entry", "sequence": { "sequence": "MGGPHGGPFLLFHVLCFLLTLSEVGSQNSKACALPCPPNSSCVNGTACRCAPGFISFSGEIFTDPLESCDDINECGPPSPVDCGSSADCQNTEGGYYCTCSPGYEPVSGAMIFRNESENTCRDVDECQHRPRVCKGRSVCINTEGSYTCQCPPGLEFSPEDPRHCTDVNECTSGKKPCHSSTHCLNSVGSYECRCRPGWKPIAGSPNGPNNTVCEDVDECSSGQHQCHNSTVCFNTVGSYTCHCREGWEPKHGLKNKQKDTICKEISFPAWTAPPGIKSRSLSAFFERVQKMSRDFKPAMAKKSMQDLVGSVDDLLKNSGDLESLDQSSKHVTVTHLLSGLEQILRTLAKAMPKGSFTYRSLDNTELSLVVQEQGKGNVTVGQSHARMLLDWAVAAAAEESGPTVVGILSSQNMKKLLANASLKLDSEKLKETYKSPVRGAKVTLLSAVSSVFLSNTNTEKLDSNVSFAFALHEQPELKPRQELICAFWKKDSNGNGSWATTGCWKMGRGNGSITCQCSHLSSFAILMAHYDVEDPKLALITKVGLALSLACLLLCILTFLLVRPIQGSRTTVHLHLCICLFVGSAIFLAGIENEGGEVGTRCRLVAVLLHYCFLAAFCWMSLEGVELYFLVVRVFQGQGLRKLWLCLIGYGVPLIIVGISAGAYSKGYGREKFCWLNFEGGFLWSFVGPVTFIVLGNAIIFVITVWKLTQKFSEINPDIKKLKKARVLTITAIAQLFVLGCTWVFGLLLFDPESWVLSYIFSILNCLQGFFLFVLYCLLNKKVREEYRKWACMVAGNKYSEFATTTSGSGSSHNQTQALRPSESGM", "length": 827, "header": "tr|F1MCN3-1|F1MCN3_BOVIN Isoform 1 of Adhesion G protein-coupled receptor E5 OS=Bos taurus OX=9913 GN=ADGRE5 PE=3 SV=1 CANONICAL=F1MCN3-1" }, "locus": { "chromosome": "7", "start_pos": 11371416, "end_pos": 11354132, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029084.7", "url": "https://www.ensembl.org/id/ENSBTAT00000029084.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029084.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029084.5" } ] } }, { "isoform_ac": "F6R6T6-1", "url": "https://www.uniprot.org/uniprotkb/F6R6T6/entry", "sequence": { "sequence": "MGGPHGGPFLLFHVLCFLLTLSEVGSQNSKACALPCPPNSSCVNGTACRCAPGFISFSGEIFTDPLESCDDINECGPPSPVDCGSSADCQNTEGGYYCTCSPGYEPVSGAMIFRNESENTCRDVNECTSGKKPCHSSTHCLNSVGSYECRCRPGWKPIAGSPNGPNNTVCEDVDECSSGQHQCHNSTVCFNTVGSYTCHCREGWEPKHGLKNKQKDTICKEISFPAWTAPPGIKSRSLSAFFERVQKMSRDFKPAMAKKSMQDLVGSVDDLLKNSGDLESLDQSSKHVTVTHLLSGLEQILRTLAKAMPKGSFTYRSLDNTELSLVVQEQGKGNVTVGQSHARMLLDWAVAAAAEESGPTVVGILSSQNMKKLLANASLKLDSEKLKETYKSPVRGAKVTLLSAVSSVFLSNTNTEKLDSNVSFAFALHEQPELKPRQELICAFWKKDSNGNGSWATTGCWKMGRGNGSITCQCSHLSSFAILMAHYDVEDPKLALITKVGLALSLACLLLCILTFLLVRPIQGSRTTVHLHLCICLFVGSAIFLAGIENEGGEVGTRCRLVAVLLHYCFLAAFCWMSLEGVELYFLVVRVFQGQGLRKLWLCLIGYGVPLIIVGISAGAYSKGYGREKFCWLNFEGGFLWSFVGPVTFIVLGNAIIFVITVWKLTQKFSEINPDIKKLKKARVLTITAIAQLFVLGCTWVFGLLLFDPESWVLSYIFSILNCLQGFFLFVLYCLLNKKVREEYRKWACMVAGNKYSEFATTTSGSGSSHNQTQALRPSESGM", "length": 783, "header": "tr|F6R6T6-1|F1MCN3_BOVIN Computationally mapped isoform of Adhesion G protein-coupled receptor E5 OS=Bos taurus OX=9913 GN=ADGRE5 PE=3 SV=1 CANONICAL=F1MCN3-1" }, "locus": { "chromosome": "7", "start_pos": 11371416, "end_pos": 11354132, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029086.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029086.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029086.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029086.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-373080", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373080", "resource": "Reactome", "description": "Class B/2 (Secretin family receptors)" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LY89-1", "protein_name": "Adhesion G protein-coupled receptor E5", "gene_name": "Adgre5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCFGPCPSSRGDRVSGPRAQSGVAFVPGAGARRALGLFPRHFPVTFQRGGQFRGGPCPRPLHKGPAQPPATALCQPRRCPFRATMRGVSCHLLLVLCFVPNLSGVGTQKASGCARWCPPNSECESNRSCKCKPGFNSSSPDGLITNPAQSCEDINECIQTDNLCGPYAMCMNSEGSYYCVCNLGYKLLSGAESFTNKSENTCQASVDTGMIPVPSSIHTVPTARKLPEQPTTVHPRTQLGDSGERTPKDVNECTSGQNQCHQSTHCINKMGGYSCICRRGWKPAPGSPNGPVNTVCEDVDECSSGQHQCHSSAICKNIPGSYKCRCPPGWIAIPRDKPNNTVCQEPHFPTWTLLPTAHSQALLSFSVEVQNLLRDFNPATVNYTIQKLIEAVDKLLEMPMDIGTQTQQVATQLLSNLEQSLRTLAQFLPKGPFTYKSPSNTELALMVKEQDNKDVTTVHHSQAWMQLDWAVTAGAKSSENGYSVAGILSSPNIQKLLANTSLNLEQKRDTLEDLYGSPVQSVTLTFLSNINAIFLTNTDTEKLASDVTFKFNLTSVKSLKAREELMCAYWKSHDNGSGSWATDGCSMNDTGFCHCNHLTSFAVLMAQYHVQDPRLELITKVGLLLSLVCLLLCILTFLLVKPIQSSRTMVHLHLCICLFLGSVIFLVGVENEGGEVGLRCRLVAMLLHFCFLAAFCWMALEGVELYFLVVRVFQGQGLSTWHRCLVGYGVPLLIVAISAAARMDGYGHATYCWLDFRKQGFLWSFSGPVAFIIFCNAAIFVITVWKLTKKFSEINPNMKKLRKARVLTITAIAQLLVLGCTWGFGLFLFNPHSTWLSYIFTLLNCLQGLFLYVTLCLLNKKVREEYWKWACMVTGNKYTEFTSSTTGTGTSQTRTLRPSESGM", "length": 903 }, "evidence": [ { "id": "F1MCN3", "url": "https://omabrowser.org/oma/group/F1MCN3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "K7GMF6-1", "protein_name": "Adhesion G protein-coupled receptor E5", "gene_name": "ADGRE5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMGVPSHHVLTMVSISTSVPTACARWCPLNSSCVNSTACRCNLGFSASSGEVFTSPSDSCDDINECAPPTTVSCGKNADCQNTEGGYHCTCVPGYELASGAPIFRNENENTCQDVDECQQKPKICKSRGICINTQGSYTCQCPPGFKLNPRDPKLCTDVNECTPGSNPCHNSTHCFNLVGRYECRCRPGWKPIPGSPNGPNNTICEDKDECSSGEHKCHNSTICTNTVGSYACHCRRGWVPKPGFQNKKNTTVCEEVSFPTWTPPPGIKSQSLSLFFERVQNMRRDFKADLTQKTMKDLIVSLDDLLKTPGDLEALNLSSRHQTATSLLTGLEEILRTLGKAFSNDSFTFYSPGGTVLSLVVQEPGSGNITVGQSHARMLLDWAVAAGAGKSDPTVVGILSIPNMQKLLSNSSLDLDLEKKAKLEECYESSVHGAQLRLLSAVNSVFLSNTNTDKLDSPVTFAFSHLPGTQEQKEHGPREERICAFWKHDGSNGGHWATSGCRILGNGNDSTTCQCNHLSSFAILVAHYNVEDPKLALITKVGLSLSLVCLLLCILTFLLVRPIQGSRTTVHLHLCICLFVGSAIFLAGIENEGGQVGLRCSLVAGLLHYWFLAAFCWMSLEGMELYFLVVRVFQGQGLRKRWLCLIGYGVPLVIVVISAIFAATYKEGYGNALYCWLSHKHGFHWSFQGPVTFIVLCNAVIFVTTVWKLTQKFSEINPDIKKLKKARVLTITAIAQLFVLGCTWVFGLLLFDPRSWVLSYIFTILNCLQGFFLFLLYCLLNKKVREEYRKWACMVTRNKYSEFATTTSASSSSHSQTRALRPSQSGM", "length": 828 }, "evidence": [ { "id": "F1MCN3", "url": "https://omabrowser.org/oma/group/F1MCN3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P48960-1", "protein_name": "Adhesion G protein-coupled receptor E5", "gene_name": "ADGRE5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASESGI", "length": 835 }, "evidence": [ { "id": "F1MCN3", "url": "https://omabrowser.org/oma/group/F1MCN3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z0M6-1", "protein_name": "Adhesion G protein-coupled receptor E5", "gene_name": "Adgre5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRGVRCPGLLVVCILLSLSGAGTQKAESKNCAKWCPINSKCVSNRSCVCKPGFSSEKELITNPAESCEDINECLLPGFSCGDFAMCKNSEGSYTCVCNLGYKLLSGAESFVNESENTCQASVNTGTTPVPSRIHTVTTAPGNLPEQTTTVHQTQMGDSEERTPKDVNECISGQNHCHQSTHCINKLGGYSCICRQGWKPVPGSPNGPVSTVCEDVDECSSGQHQCHNSTVCKNTVGSYKCHCRPGWKPTSGSLRGPDTICQEPPFPTWTLLPTAHSQTLLRFSVEVQNLLRDFNPATVNYTIQKLIEAVDKLLEDPMETQTQQVAAQLLSNLEQSLRTLAQFLPKGPFTYTSPSNTELSLMVKEQDNKDVTTVHHGQTWMELDWAVTAGAKISENGSSVAGILSSPNMEKLLGNTPLNLEQRRASLEDFYGSPIPSVSLKLLSNINSVFLTNTNTEKLASNVTFKFDFTSVESIEPRHELICAFWKAHNGNGYWDTDGCSMNGTGFCHCNHLTSFAILMAQYHVQDPRLELITKVGLLLSLICLLLCILTFLLVKPIQSSRTMVHLHLCICLFLGSIIFLVGVENEGGEVGLRCRLVAMMLHFCFLAAFCWMALEGVELYFLVVRVFQGQGLSTWQRCLIGYGVPLLIVAISMAVVKMDGYGHATYCWLDFRKQGFLWSFSGPVAFIIFCNAAIFVITVWKLTKKFSEINPNMKKLRKARVLTITAIAQLLVLGCTWGFGLFLFNPHSTWLSYIFTLLNCLQGLFLYVMLCLLNKKVREEYWKWACMVTGSKYTEFNSSTTGTGTSQTRALRSSESGM", "length": 818 }, "evidence": [ { "id": "F1MCN3", "url": "https://omabrowser.org/oma/group/F1MCN3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MCN3", "url": "https://www.uniprot.org/uniprotkb/F1MCN3" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MCN3", "url": "https://www.uniprot.org/uniprotkb/F1MCN3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MCN3", "url": "https://www.uniprot.org/uniprotkb/F1MCN3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MCN3", "url": "https://www.uniprot.org/uniprotkb/F1MCN3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1MCN3", "url": "https://www.uniprot.org/uniprotkb/F1MCN3" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "F1MCN3", "url": "https://www.uniprot.org/uniprotkb/F1MCN3" } ], "pmid": "" }, { "name": "immune system process", "id": "GO:0002376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002376", "evidence": [ { "database": "UniProtKB", "id": "F1MCN3", "url": "https://www.uniprot.org/uniprotkb/F1MCN3" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "F1MCN3", "url": "https://www.uniprot.org/uniprotkb/F1MCN3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 115, "end_pos": 117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" }, { "start_pos": 378, "end_pos": 380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 420, "end_pos": 422, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" }, { "start_pos": 496, "end_pos": 498, "annotation": "n_glycosylation_sequon" }, { "start_pos": 511, "end_pos": 513, "annotation": "n_glycosylation_sequon" }, { "start_pos": 815, "end_pos": 817, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MCN3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 827, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MCN3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MCN3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCN3" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 71, "end_pos": 110, "start_aa": "Asp", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": 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"label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 115, "end_pos": 117 }, { "start_pos": 210, "end_pos": 212 }, { "start_pos": 229, "end_pos": 231 }, { "start_pos": 378, "end_pos": 380 }, { "start_pos": 39, "end_pos": 41 }, { "start_pos": 420, "end_pos": 422 }, { "start_pos": 44, "end_pos": 46 }, { "start_pos": 465, "end_pos": 467 }, { "start_pos": 496, "end_pos": 498 }, { "start_pos": 511, "end_pos": 513 }, { "start_pos": 815, "end_pos": 817 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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"F1MIF2", "url": "https://alphafold.ebi.ac.uk/entry/F1MIF2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001189", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001189", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506192", "url": "https://www.ncbi.nlm.nih.gov/gene/506192", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002553", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002553", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012295", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012295", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013037", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013037", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013041", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013041", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016342", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016342", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LMB5", "url": "https://www.orthodb.org/?gene=A0A3Q1LMB5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11134", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11134", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01602", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01602", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02883", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02883", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09066", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09066", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2132295", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-432720", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432720", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-432722", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LMB5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMB5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMB5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMB5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M481", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M481", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M481-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M481-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU32", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU32-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8P4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8P4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8P4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8P4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIF2", "url": "https://www.uniprot.org/uniprotkb/F1MIF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIF2-1", "url": "https://www.uniprot.org/uniprotkb/F1MIF2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYTPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEVLKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASSESTESPETAPAGAPPGEQLDAVPTQGDLLGDLLNLDLGPPVSGPPLAASAVQMGAVDLLGGGLDSLMGDEPEGIGAPSFVAPPAAAVPANLGAPMGSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQAGTISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHAPLSPTQTVEISLPLSTAGSVMKTEPLNSLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAVSSRLQSSNIFTVARRNVEGQDMLYQSLKLTNGIWVLAELRIQPGNPSFTDLELSLKCRAPEVSQHVYQAYETILKN", "length": 949, "header": "tr|F1MIF2-1|F1MIF2_BOVIN Isoform 1 of AP complex subunit beta OS=Bos taurus OX=9913 GN=AP1B1 PE=3 SV=3 CANONICAL=F1MIF2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LMB5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMB5/entry", "sequence": { "sequence": "MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYTPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEVLKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASSESTESPETAPAGAPPGEQLDAVPTQGDLLGDLLNLDLGPPVSGPPLAASAVQMGAVDLLGGGLDSLIGAPSFVAPPAAAVPANLGAPMGSGLSDLFDLTSGVGTLSGSYVAPKARLRSGFGHTEASLSRAAPAVGHPEAGTPGRPGRVLLLIPRLTWSSPGGPGRCGPSESPLQVWLPAMKAKGLEISGTFTRQAGTISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHAPLSPTQTVEISLPLSTAGSVMKTEPLNSLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAVSSRLQSSNIFTVARRNVEGQDMLYQSLKLTNGIWVLAELRIQPGNPSFTLSLKCRAPEVSQHVYQAYETILKN", "length": 999, "header": "tr|A0A3Q1LMB5-1|F1MIF2_BOVIN Computationally mapped isoform of AP complex subunit beta OS=Bos taurus OX=9913 GN=AP1B1 PE=3 SV=2 CANONICAL=F1MIF2-1" }, "locus": { "chromosome": "17", "start_pos": 68629034, "end_pos": 68599690, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082015.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082015.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061024.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061024.2" } ] } }, { "isoform_ac": "A0A3Q1M481-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M481/entry", "sequence": { "sequence": "MSTGFGLRPGTLGSSLSFVSLSFVFYKMGIIYRLLRALKGDHMKTLCVSALALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYTPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEVLKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTTAPAGAPPGEQLDAVPTQGDLLGDLLNLDLGPPVSGPPLAASAVQMGAVDLLGGGLDSLVRPGPPDEVDGGLQGGIRNAFSAGCGVGAVAAPSPSFSPQVWLPAMKAKGLEISGTFTRQAGTISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHAPLSPTQTVEISLPLSTAGSVMKTEPLNSLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAVSSRLQSSNIFTVARRNVEGQDMLYQSLKLTNGIWVLAELRIQPGNPSFTLSLKCRAPEVSQHVYQAYETILKN", "length": 924, "header": "tr|A0A3Q1M481-1|F1MIF2_BOVIN Computationally mapped isoform of AP complex subunit beta OS=Bos taurus OX=9913 GN=AP1B1 PE=3 SV=2 CANONICAL=F1MIF2-1" }, "locus": { "chromosome": "17", "start_pos": 68624120, "end_pos": 68599690, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083678.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083678.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068379.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068379.2" } ] } }, { "isoform_ac": "A0AAA9SU32-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU32/entry", "sequence": { "sequence": "MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYTPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEVLKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASSESTESPETAPAGAPPGEQLDAVPTQGDLLGDLLNLDLGPPVSGPPLAASAVQMGAVDLLGGGLDSLIGAPSFVAPPAAAVPANLGAPMGSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQAGTISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHAPLSPTQTVEISLPLSTAGSVMKTEPLNSLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAVSSRLQSSNIFTVARRNVEGQDMLYQSLKLTNGIWVLAELRIQPGNPSFTVRRPLPPKAPGPLPSCPHACPGWGRPWWGGVGWGIHPGVKKHQDSDLRKLQLSPIKCLR", "length": 974, "header": "tr|A0AAA9SU32-1|F1MIF2_BOVIN Computationally mapped isoform of AP complex subunit beta OS=Bos taurus OX=9913 GN=AP1B1 PE=3 SV=1 CANONICAL=F1MIF2-1" }, "locus": { "chromosome": "17", "start_pos": 68629034, "end_pos": 68600802, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097109.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097109.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088845.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088845.1" } ] } }, { "isoform_ac": "A0AAA9T8P4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8P4/entry", "sequence": { "sequence": "MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYTPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEVLKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASSESTESPETAPAGAPPGEQLDAVPTQGDLLGDLLNLDLGPPVSGPPLAASAVQMGAVDLLGGGLDSLMGDEPEGIGAPSFVAPPAAAVPANLGAPMGSGLSDLFDLTSGVGTLSGSYVAPKARLRSGFGHTEASLSRAAPAVGHPEAGTPGRPGRVLLLIPRLTWSSPGGPGRCGPSESPLQVWLPAMKAKGLEISGTFTRQAGTISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHAPLSPTQTVEISLPLSTAGSVMKTEPLNSLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAVSSRLQSSNIFTVARRNVEGQDMLYQSLKLTNGIWVLAELRIQPGNPSFTLSLKCRAPEVSQHVYQAYETILKN", "length": 1006, "header": "tr|A0AAA9T8P4-1|F1MIF2_BOVIN Computationally mapped isoform of AP complex subunit beta OS=Bos taurus OX=9913 GN=AP1B1 PE=3 SV=1 CANONICAL=F1MIF2-1" }, "locus": { "chromosome": "17", "start_pos": 68629034, "end_pos": 68599690, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131160.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131160.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093182.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093182.1" } ] } }, { "isoform_ac": "F1MIF2-1", "url": "https://www.uniprot.org/uniprotkb/F1MIF2/entry", "sequence": { "sequence": "MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYTPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEVLKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASSESTESPETAPAGAPPGEQLDAVPTQGDLLGDLLNLDLGPPVSGPPLAASAVQMGAVDLLGGGLDSLMGDEPEGIGAPSFVAPPAAAVPANLGAPMGSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQAGTISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHAPLSPTQTVEISLPLSTAGSVMKTEPLNSLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAVSSRLQSSNIFTVARRNVEGQDMLYQSLKLTNGIWVLAELRIQPGNPSFTDLELSLKCRAPEVSQHVYQAYETILKN", "length": 949, "header": "tr|F1MIF2-1|F1MIF2_BOVIN Isoform 1 of AP complex subunit beta OS=Bos taurus OX=9913 GN=AP1B1 PE=3 SV=3 CANONICAL=F1MIF2-1" }, "locus": { "chromosome": "17", "start_pos": 68629034, "end_pos": 68599690, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001576.6", "url": "https://www.ensembl.org/id/ENSBTAT00000001576.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001576.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001576.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2132295", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2132295", "resource": "Reactome", "description": "MHC class II antigen presentation" }, { "id": "R-BTA-432720", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432720", "resource": "Reactome", "description": "Lysosome Vesicle Biogenesis" }, { "id": "R-BTA-432722", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-432722", "resource": "Reactome", "description": "Golgi Associated Vesicle Biogenesis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "F1MIF2", "url": "https://www.uniprot.org/uniprotkb/F1MIF2" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "F1MIF2", "url": "https://www.uniprot.org/uniprotkb/F1MIF2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "F1MIF2", "url": "https://www.uniprot.org/uniprotkb/F1MIF2" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "F1MIF2", "url": "https://www.uniprot.org/uniprotkb/F1MIF2" } ], "pmid": "" }, { "name": "clathrin adaptor complex", "id": "GO:0030131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030131", "evidence": [ { "database": "UniProtKB", "id": "F1MIF2", "url": "https://www.uniprot.org/uniprotkb/F1MIF2" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1MIF2", "url": "https://www.uniprot.org/uniprotkb/F1MIF2" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "F1MIF2", "url": "https://www.uniprot.org/uniprotkb/F1MIF2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "clathrin binding", "id": "GO:0030276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030276", "evidence": [ { "database": "UniProtKB", "id": "F1MIF2", "url": "https://www.uniprot.org/uniprotkb/F1MIF2" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "F1MIF2", "url": "https://www.uniprot.org/uniprotkb/F1MIF2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MIF2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 949, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MIF2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MIF2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MIF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIF2" }, { "id": "SM01020", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01020" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Beta-adaptin appendage C-terminal subdomain", "eco_id": "ECO_0000259", "start_pos": 835, "end_pos": 948, "start_aa": "Phe", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MIF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIF2" }, { "id": "SM00809", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00809" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain", "eco_id": "ECO_0000259", "start_pos": 716, "end_pos": 826, "start_aa": "Tyr", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 228, "end_pos": 230 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MAV2-1", "uniprot_ac": "F1MAV2", "uniprot_id": "F1MAV2_BOVIN", "mass": { "chemical_mass": 45288.0, "monoisotopic_mass": 45288.0 }, "refseq": {}, "gene_names": [ { "name": "ARFIP1", "type": "recommended", "evidence": [ { "id": "F1MAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAV2" } ] } ], "protein_names": [ { "name": "ADP ribosylation factor interacting protein 1", "type": "synonym", "evidence": [ { "id": "F1MAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAV2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MAV2", "url": "https://www.uniprot.org/uniprotkb/F1MAV2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ARFIP1", "url": "https://www.uniprot.org/uniprotkb/F1MAV2", "locus": { "chromosome": "17", "start_pos": 4730019, "end_pos": 4887692, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008438", "url": "https://www.ensembl.org/id/ENSBTAG00000008438" } ] } } ], "crossref": [ { "id": "F1MAV2", "url": "https://alphafold.ebi.ac.uk/entry/F1MAV2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008438", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008438", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07660", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07660", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507386", "url": "https://www.ncbi.nlm.nih.gov/gene/507386", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR010504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030798", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030798", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HRRHYER", "url": "https://omabrowser.org/oma/group/HRRHYER/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LN78", "url": "https://www.orthodb.org/?gene=A0A3Q1LN78", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MAV2", "url": "https://www.orthodb.org/?gene=F1MAV2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12141", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12141", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12141:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12141:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06456", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06456", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LN78", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LN78-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTV7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTV7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTV7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTB9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTB9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPQ2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T269", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T269", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T269-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T269-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MAV2", "url": "https://www.uniprot.org/uniprotkb/F1MAV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MAV2-1", "url": "https://www.uniprot.org/uniprotkb/F1MAV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQESPKNSAAEIPVTSNGEVDDSHEHGFNRDLKRSLPAGLGLSETQITSHGFDSTKEGVIEAGSFQGSPAPPLPSVMSPSRVAASRLTQQGSDLIVPAGIHCTDRIKPFLLLLKLNSLTQFPIACFIFLGSQRTQTKSGPVILADETKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKLKTPGVDAPSWLEEQ", "length": 404, "header": "tr|F1MAV2-1|F1MAV2_BOVIN Isoform 1 of ADP ribosylation factor interacting protein 1 OS=Bos taurus OX=9913 GN=ARFIP1 PE=4 SV=3 CANONICAL=F1MAV2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LN78-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN78/entry", "sequence": { "sequence": "MSDCSNDTSTLGTSKPATEEVKSSSEESTMAQESPKNSAAEIPVTSNGEVDDSHEHGFNRDLKRSLPAGLGLSETQITSHGFDSTKEGVIEAGSFQGSPAPPLPSVMSPSRVAASRLTQQGSDLIVPAGSQRTQTKSGPVILADETKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKLKTPGVDAPSWLEEQ", "length": 402, "header": "tr|A0A3Q1LN78-1|F1MAV2_BOVIN Computationally mapped isoform of ADP ribosylation factor interacting protein 1 OS=Bos taurus OX=9913 GN=ARFIP1 PE=4 SV=1 CANONICAL=F1MAV2-1" }, "locus": { "chromosome": "17", "start_pos": 4846862, "end_pos": 4731720, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104168.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104168.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101527.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101527.1" } ] } }, { "isoform_ac": "A0A3Q1LTV7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTV7/entry", "sequence": { "sequence": "MAQESPKNSAAEIPVTSNGEVDDSHEHGFNRDLKRSLPAGLGLSETQITSHGFDSTKEGVIEAGSFQGSQRTQTKSGPVILADETKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKDCPFLPHGIGLHSVMSDSATPWTVTLQAAQSMGFSGQEYWSGLPFLSPGDLPDPGMKPRSPVLQAGATREATFYLIGCFFFLT", "length": 373, "header": "tr|A0A3Q1LTV7-1|F1MAV2_BOVIN Computationally mapped isoform of ADP ribosylation factor interacting protein 1 OS=Bos taurus OX=9913 GN=ARFIP1 PE=4 SV=1 CANONICAL=F1MAV2-1" }, "locus": { "chromosome": "17", "start_pos": 4817277, "end_pos": 4750604, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080264.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080264.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060531.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060531.2" } ] } }, { "isoform_ac": "A0AAA9RTB9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTB9/entry", "sequence": { "sequence": "MILQLLVHLNQPQKKSSLVLRWHRIAGMCWLWPFPKQARLWFLLRESTMAQESPKNSAAEIPVTSNGEVDDSHEHGFNRDLKRSLPAGLGLSETQITSHGFDSTKEGVIEAGSFQGSQRTQTKSGPVILADETKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKLKTPGVDAPSWLEEQ", "length": 389, "header": "tr|A0AAA9RTB9-1|F1MAV2_BOVIN Computationally mapped isoform of ADP ribosylation factor interacting protein 1 OS=Bos taurus OX=9913 GN=ARFIP1 PE=4 SV=1 CANONICAL=F1MAV2-1" }, "locus": { "chromosome": "17", "start_pos": 4846846, "end_pos": 4731720, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101087.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101087.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075084.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075084.1" } ] } }, { "isoform_ac": "A0AAA9SPQ2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPQ2/entry", "sequence": { "sequence": "MRVLCSTVLESTMAQESPKNSAAEIPVTSNGEVDDSHEHGFNRDLKRSLPAGLGLSETQITSHGFDSTKEGVIEAGSFQGSPAPPLPSVMSPSRVAASRLTQQGSDLIVPAGSQRTQTKSGPVILADETKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKLKTPGVDAPSWLEEQ", "length": 385, "header": "tr|A0AAA9SPQ2-1|F1MAV2_BOVIN Computationally mapped isoform of ADP ribosylation factor interacting protein 1 OS=Bos taurus OX=9913 GN=ARFIP1 PE=4 SV=1 CANONICAL=F1MAV2-1" }, "locus": { "chromosome": "17", "start_pos": 4833959, "end_pos": 4731720, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134462.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134462.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085913.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085913.1" } ] } }, { "isoform_ac": "A0AAA9T269-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T269/entry", "sequence": { "sequence": "MCWLWPFPKQARLWFLLRESTMAQESPKNSAAEIPVTSNGEVDDSHEHGFNRDLKRSLPAGLGLSETQITSHGFDSTKEGVIEAGSFQGSPAPPLPSVMSPSRVAASRLTQQGSDLIVPAGSQRTQTKSGPVILADETKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKLKTPGVDAPSWLEEQ", "length": 394, "header": "tr|A0AAA9T269-1|F1MAV2_BOVIN Computationally mapped isoform of ADP ribosylation factor interacting protein 1 OS=Bos taurus OX=9913 GN=ARFIP1 PE=4 SV=1 CANONICAL=F1MAV2-1" }, "locus": { "chromosome": "17", "start_pos": 4832263, "end_pos": 4731720, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089372.1", "url": "https://www.ensembl.org/id/ENSBTAT00000089372.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092893.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092893.1" } ] } }, { "isoform_ac": "A0AAA9TMB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMB0/entry", "sequence": { "sequence": "MAQESPKNSAAEIPVTSNGEVDDSHEHGFNREEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKLKTPGVDAPSWLEEQ", "length": 193, "header": "tr|A0AAA9TMB0-1|F1MAV2_BOVIN Computationally mapped isoform of ADP ribosylation factor interacting protein 1 OS=Bos taurus OX=9913 GN=ARFIP1 PE=4 SV=1 CANONICAL=F1MAV2-1" }, "locus": { "chromosome": "17", "start_pos": 4817277, "end_pos": 4731720, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095485.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095485.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098380.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098380.1" } ] } }, { "isoform_ac": "F1MAV2-1", "url": "https://www.uniprot.org/uniprotkb/F1MAV2/entry", "sequence": { "sequence": "MAQESPKNSAAEIPVTSNGEVDDSHEHGFNRDLKRSLPAGLGLSETQITSHGFDSTKEGVIEAGSFQGSPAPPLPSVMSPSRVAASRLTQQGSDLIVPAGIHCTDRIKPFLLLLKLNSLTQFPIACFIFLGSQRTQTKSGPVILADETKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKLKTPGVDAPSWLEEQ", "length": 404, "header": "tr|F1MAV2-1|F1MAV2_BOVIN Isoform 1 of ADP ribosylation factor interacting protein 1 OS=Bos taurus OX=9913 GN=ARFIP1 PE=4 SV=3 CANONICAL=F1MAV2-1" }, "locus": { "chromosome": "17", "start_pos": 4817277, "end_pos": 4731720, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029827.6", "url": "https://www.ensembl.org/id/ENSBTAT00000029827.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029823.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029823.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287B8Z3-1", "protein_name": "ADP ribosylation factor interacting protein 1", "gene_name": "ARFIP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWLLGPQREGRGPPPGGRWRGPWGRCAGTIETRLGRPDRGRERPSRATDNATSGPLTSGSAALGSGVAGRVGRPRLCVSSAVGQGEAVTAALAPRPRGAEESTMAQESPKNSAAEIPVTSNGEVDDPHDHGFNRDFKRSLPAGLGLSETQITSHGFDGTKEGVIDAGTFQGSPAPPLPSVMSPSRVAASRLAEQGGDLIAPAGGQRTQTKSGPVILADEAKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSIKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKLKTPGVDAPSWLEEQ", "length": 476 }, "evidence": [ { "id": "F1MAV2", "url": "https://omabrowser.org/oma/group/F1MAV2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HQA3-1", "protein_name": "Arfaptin-1 isoform X2", "gene_name": "Arfip1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAQESPKNSAAEIPVTSNGEVEDSHEHAYHRDLKHSLPSGLGLSETQITSHGFDGTKEGVIEAGASQGPSAPPLPSVLSPSRVAASQLAQQGGDLTVPAGGQRTHTKGGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLATQLFQMVHTQKQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYENARIEYDAYRTDLEELNLGPRDANTLPKIEHSQHLFQIHKEKYDKMRSDVSVKLKFLEENKVKVLRNQLVLFHSAVAAYFAGNQKQLELTLKQFHVKLKTPGVDAPSWLEEQ", "length": 373 }, "evidence": [ { "id": "F1MAV2", "url": "https://omabrowser.org/oma/group/F1MAV2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G5E8V9-1", "protein_name": "Arfaptin-1", "gene_name": "Arfip1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQESPKNSAAEIPVTSNGEVDDAHEHGYNRDLKHSLPSGLGLSETQITSHGFDSTKEGVTEAGAPQGSSAPPLPCVLSPSRVAASKLTQQAGDLTVPAGGQRTHTKGGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQKQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYENARVEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQIHKEKYDKMRSDVSVKLKFLEENKVKVLRNQLVLFHSAVAAYFAGNQKQLELTLKQFHVRLKTPGVDAPSWLEEQ", "length": 373 }, "evidence": [ { "id": "F1MAV2", "url": "https://omabrowser.org/oma/group/F1MAV2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P53367-1", "protein_name": "Arfaptin-1", "gene_name": "ARFIP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQESPKNSAAEIPVTSNGEVDDSREHSFNRDLKHSLPSGLGLSETQITSHGFDNTKEGVIEAGAFQGSPAPPLPSVMSPSRVAASRLAQQGSDLIVPAGGQRTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFHNAIAAYFAGNQKQLEQTLKQFHIKLKTPGVDAPSWLEEQ", "length": 373 }, "evidence": [ { "id": "F1MAV2", "url": "https://omabrowser.org/oma/group/F1MAV2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JHU5-1", "protein_name": "Arfaptin-1", "gene_name": "Arfip1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEESPKNSAAEIPVTSNGEVGDAHEHGYNRDLKHSLPSGLGLSETQITSHGFDSTKEGVTEAGASQGSSAPPLPCVLSPSRVAASQLTQHAGGQRTHTKGGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEAQIDILRDNKKKYENILKLAQTLSTQLFQMVHTQKQLGDAFADLSLKSLELHEEFGYNADTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYENARIEYDAYRTDLEELNLGPRDANTLPKIEQSQHLFQIHKEKYDKMRSDVSVKLKFLEENKVKVLRNQLALFHSAVAAYFAGNQKQLEQTLKQFHVKLKTPGVDAPSWLEEQ", "length": 366 }, "evidence": [ { "id": "F1MAV2", "url": "https://omabrowser.org/oma/group/F1MAV2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MAV2", "url": "https://www.uniprot.org/uniprotkb/F1MAV2" } ], "pmid": "" }, { "name": "trans-Golgi network membrane", "id": "GO:0032588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032588", "evidence": [ { "database": "UniProtKB", "id": "F1MAV2", "url": "https://www.uniprot.org/uniprotkb/F1MAV2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MAV2", "url": "https://www.uniprot.org/uniprotkb/F1MAV2" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F1MAV2", "url": "https://www.uniprot.org/uniprotkb/F1MAV2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "F1MAV2", "url": "https://www.uniprot.org/uniprotkb/F1MAV2" } ], "pmid": "" }, { "name": "phosphatidylinositol-4-phosphate binding", "id": "GO:0070273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070273", "evidence": [ { "database": "UniProtKB", "id": "F1MAV2", "url": "https://www.uniprot.org/uniprotkb/F1MAV2" } ], "pmid": "" }, { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "F1MAV2", "url": "https://www.uniprot.org/uniprotkb/F1MAV2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "F1MAV2", "url": "https://www.uniprot.org/uniprotkb/F1MAV2" } ], "pmid": "" }, { "name": "negative regulation of retrograde transport, endosome to Golgi", "id": "GO:1905280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905280", "evidence": [ { "database": "UniProtKB", "id": "F1MAV2", "url": "https://www.uniprot.org/uniprotkb/F1MAV2" } ], "pmid": "" }, { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "F1MAV2", "url": "https://www.uniprot.org/uniprotkb/F1MAV2" } ], "pmid": "" }, { "name": "regulation of Arp2/3 complex-mediated actin nucleation", "id": "GO:0034315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034315", "evidence": [ { "database": "UniProtKB", "id": "F1MAV2", "url": "https://www.uniprot.org/uniprotkb/F1MAV2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MAV2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 404, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MAV2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MAV2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAV2" }, { "id": "PS50870", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50870" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AH", "eco_id": "ECO_0000259", "start_pos": 184, "end_pos": 384, "start_aa": "Thr", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 278, "end_pos": 280 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { 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"database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002893", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002893", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013289", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013289", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014896", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014896", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527740", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527740", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WKHLDHX", "url": "https://omabrowser.org/oma/group/WKHLDHX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LNW6", "url": "https://www.orthodb.org/?gene=A0A3Q1LNW6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MJ18", "url": "https://www.orthodb.org/?gene=F1MJ18", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10379", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10379", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10379:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10379:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01753", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01753", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07531", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07531", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08788", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08788", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002692347", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692347", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNW6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNW6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ18", "url": "https://www.uniprot.org/uniprotkb/F1MJ18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ18-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ18-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGVPGAAAFQLGADKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREESSFERDAIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPSKMIEHREVRDRHHNLSLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRFNENTEMRKTGSELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHSQSRPLLPGGRGSSARSADCSVPSPALDKTSATTSRSSTPASVTAIDTNGL", "length": 595, "header": "tr|F1MJ18-1|F1MJ18_BOVIN Isoform 1 of CBFA2/RUNX1 partner transcriptional co-repressor 2 OS=Bos taurus OX=9913 GN=CBFA2T2 PE=3 SV=2 CANONICAL=F1MJ18-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LNW6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNW6/entry", "sequence": { "sequence": "MVGVPGAAAFQLGADKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREESSFERDAIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPSKMIEHREVRDRHHNLSLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRFNENTEMRKTGSELVSRQHSPGSADSLSNEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHSQSRPLLPGGRGSSARSADCSVPSPALDKTSATTSRSSTPASVTAIDTNGL", "length": 572, "header": "tr|A0A3Q1LNW6-1|F1MJ18_BOVIN Computationally mapped isoform of CBFA2/RUNX1 partner transcriptional co-repressor 2 OS=Bos taurus OX=9913 GN=CBFA2T2 PE=3 SV=2 CANONICAL=F1MJ18-1" }, "locus": { "chromosome": "13", "start_pos": 63094970, "end_pos": 62957800, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084073.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084073.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058542.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058542.2" } ] } }, { "isoform_ac": "F1MJ18-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ18/entry", "sequence": { "sequence": "MVGVPGAAAFQLGADKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREESSFERDAIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPSKMIEHREVRDRHHNLSLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRFNENTEMRKTGSELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHSQSRPLLPGGRGSSARSADCSVPSPALDKTSATTSRSSTPASVTAIDTNGL", "length": 595, "header": "tr|F1MJ18-1|F1MJ18_BOVIN Isoform 1 of CBFA2/RUNX1 partner transcriptional co-repressor 2 OS=Bos taurus OX=9913 GN=CBFA2T2 PE=3 SV=2 CANONICAL=F1MJ18-1" }, "locus": { "chromosome": "13", "start_pos": 63094970, "end_pos": 62957800, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013366.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013366.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013366.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013366.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 278, "start_aa": "Thr", "end_pos": 278, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr278", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:527740", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527740", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0B4KEZ2-1", "protein_name": "Nervy, isoform D", "gene_name": "nvy", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MMALDGKAIIKEEITDKDAYDAAAAAAAAVAAGAALAVASAAAVQVPPASSSSAGSASSAAAAATNNTTSAAATAAAISRRLKASSSGGDKSSTSSSSSKDSSHTSSSRSERDRERERERERERDRLCRTPPDSPPDSSRSLAPRSPHSPLQLHQHPQRNASVSPVVNGSSSGGGGVGSSGTSPTPTPGSQHAASLAAAAAAAAAAHVEQARLVSKMRKFLGALVQFSQELGQPEVCERVRALVLSLCSGSISVEEFRLALQEAINLPLRPYVVPLLKNSIALVQREILALARATNQSALQYVTNNEQAVMEFAPHGVASAEFGDIFIQLEAPTSNGSSAVFKRRSSDSMMEHGGHNGLQEWNEYMASGGAGYPPPPSKRLTLHPAHSVVAYGEYGVSSAEGLPSAAAFMQRDERDLRMSEAQARHAAPPQRAGNPQPNPNAAAPGAPGAGGEEEWKNIHTMLNCISAMVDKTKRAITILQQRGIEPQHPNSGQEVTPAAMAELRRQTEEKVAEFKRNAEDAVTQVKRQAVIEIQRAVVAAETRAAEIMTQERLRMEKFFMEMSRHSSGERDLDNKSPSMASAQNGSNLQQQCWNCGRKATETCSGCNMARYCSASCQYRDWDSHHQVCGNTRASELSAKHLHSASNLSLRNAMATRSPPTPNSAAHLQAAAAAAAAAAGAREAVSAPVGGPGAGIAVGTGAGSGGQSGGGGGGGGGGGGGAAAAAVAAATPGALVANGLGSKXRIRMMKPKKKYLC", "length": 757 }, "evidence": [ { "id": "F1MJ18", "url": "https://omabrowser.org/oma/group/F1MJ18/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "A0A8V0ZGH2-1", "protein_name": "CBFA2/RUNX1 partner transcriptional co-repressor 2", "gene_name": "CBFA2T2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLNLSLPSHEARRTTAAPLHPPSGPAWISAACPLLEALALQSLAGEKRVPVMPGSPVEVKIQTRSSPPNMPPLPPVNPGGPRPVSFTPTALPNGMNHSPPTLNGAPSPPQRFGNGPASSSSSSLTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHILLNTTSSPADSSELLIEVNGNGKRHSPDRRDDNSFEREPLPTEPPAKRVCTISPAPRHSPALSIPMLNPGGQFHPTPPPLQHYTLEDIATSHLYRDPGKMLEHREIRDRHGGLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQEADREELNYWKRRCSEAEPRKAGGELGTARHSPGSSDSIGSDSLREFSSRSGPGYVTEEIWKKAEEAVNEVKRQAMSEVQKAVAEAEQKAFEMIASERARMEQTIADAKRQATEDAFLVINEQEESTESCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRICGQSLHGHSKGLALPAGRSAKGMDGVPSPSMEKSSAATSRSSTPASVTAIDTNGL", "length": 617 }, "evidence": [ { "id": "F1MJ18", "url": "https://omabrowser.org/oma/group/F1MJ18/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0M6K1-1", "protein_name": "CBFA2/RUNX1 partner transcriptional co-repressor 2", "gene_name": "Cbfa2t2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVGVPGAAAFQLGCEKRVPAMPGSPVEVKIQSRASPPIMPPLPPINPGGPRPVSFTPTALSNGISHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPESFFYRRDENNFERDTVPPEPTAKRVCTISPAPRHSPALTVPLLSAGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRERHHNLSLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRCNENTELRKTGTELVSRQHSPGSTDSLSNDSQREFTSRPAAGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQSLHGHSPHSQSRSLLPGGRGSARSADCSVPSPALDKTSATTSRSSTPASVTAIDANGL", "length": 598 }, "evidence": [ { "id": "F1MJ18", "url": "https://omabrowser.org/oma/group/F1MJ18/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3L802-1", "protein_name": "CBFA2/RUNX1 partner transcriptional co-repressor 2", "gene_name": "CBFA2T2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVGVPGAAAFQLGADKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREESSFERDTVPPEPPAKRVCTISPAPRHSPALTVPLMNPAGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHNLSLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTEMRKTGSEMVSRQHSPGGTDSLSNDSQREFSSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHSQGRPLLPGGRGSSARSADCSVPSPALDKTSATTSRSSTPASVTAIDTNGL", "length": 595 }, "evidence": [ { "id": "F1MJ18", "url": "https://omabrowser.org/oma/group/F1MJ18/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O43439-1", "protein_name": "Protein CBFA2T2", "gene_name": "CBFA2T2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKESGISLKEIQVLARQWKVGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVGRGSSARSADCSVPSPALDKTSATTSRSSTPASVTAIDTNGL", "length": 604 }, "evidence": [ { "id": "F1MJ18", "url": "https://omabrowser.org/oma/group/F1MJ18/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O70374-1", "protein_name": "Protein CBFA2T2", "gene_name": "Cbfa2t2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVGVPGAAAFQLGCEKRVPAMPGSPVEVKIQSRSSPPIMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERRDENNFERDTVPPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRERHHNLSLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRFNENTELRKTGTELVSRQHSPGSTDSLSNDSQREFTSRPATGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQSLHGHSPHSQSRPLLPGGRGSARSADCSVPSPALDKTSATTSRSSTPASVTAIDANGL", "length": 594 }, "evidence": [ { "id": "F1MJ18", "url": "https://omabrowser.org/oma/group/F1MJ18/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MJ18", "url": "https://www.uniprot.org/uniprotkb/F1MJ18" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MJ18", "url": "https://www.uniprot.org/uniprotkb/F1MJ18" } ], "pmid": "" }, { "name": "positive regulation of neuron projection development", "id": "GO:0010976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976", "evidence": [ { "database": "UniProtKB", "id": "F1MJ18", "url": "https://www.uniprot.org/uniprotkb/F1MJ18" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "F1MJ18", "url": "https://www.uniprot.org/uniprotkb/F1MJ18" } ], "pmid": "" }, { "name": "negative regulation of Notch signaling pathway", "id": "GO:0045746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045746", "evidence": [ { "database": "UniProtKB", "id": "F1MJ18", "url": "https://www.uniprot.org/uniprotkb/F1MJ18" } ], "pmid": "" }, { "name": "intestinal epithelial cell differentiation", "id": "GO:0060575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060575", "evidence": [ { "database": "UniProtKB", "id": "F1MJ18", "url": "https://www.uniprot.org/uniprotkb/F1MJ18" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MJ18", "url": "https://www.uniprot.org/uniprotkb/F1MJ18" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "F1MJ18", "url": "https://www.uniprot.org/uniprotkb/F1MJ18" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 204, "end_pos": 206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 409, "end_pos": 411, "annotation": "n_glycosylation_sequon" }, { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJ18-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 595, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJ18-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJ18" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJ18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ18" }, { "id": "PS50865", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50865" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MYND-type", "eco_id": "ECO_0000259", "start_pos": 498, "end_pos": 534, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJ18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ18" }, { "id": "PS51119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TAFH", "eco_id": "ECO_0000259", "start_pos": 104, "end_pos": 199, "start_aa": "Ala", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 278 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 141, "end_pos": 143 }, { "start_pos": 204, "end_pos": 206 }, { "start_pos": 314, "end_pos": 316 }, { "start_pos": 409, "end_pos": 411 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", 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"MFLLLALLAALGGLLASQDSEGMFLYVTVPQKISSNESEDWEKQTPYTLHLRKHSFVSQNFLVYTYNETGSLHSESSYFKMPCHYQGYIAGFPNSVVTLSICSGLRGFLQFENISYGIEPLEFSARFEHIIYQVKNDHPDKPMFAENYSNIWQKDQSYTIHLSSQEKTFSELLPQYLEMHIIVEKALYDYMGSEMMAVTQKIIQIIGLVNAMFSQFKLTVILSYLELWSDKNQISTIGDADDLLQRFLAWKQDYLILRPHDVTLLLIYRKQPKYVGATFPGTICNRSYDADVAVYPGTITLEGFSVIIAQLLGLKIGLAYDDIQECSCPTAKCIMNHEAVLSSGVKIFSNCSMHEYRYFVSTFEAQCLQKFSILKPFYQNQSVCGNGILEAHEECDCGSEQECQFKNCCDYNTCQLKGPVQCASGSCCTSKCEISVAGTPCRKSVDPECDFTEYCNGTSSNCVPDTYAMNGQLCRLGNAYCYNGRCQTTDNQCAKVFGKGAQGAPSACFEEVNSLPNSFGNCGFKNSQPLPCEQKDVLCGKLACVWPQNSTYRSDVRSAVYSYSQGLLCVTTASSVRSGGRDYTYVADGTVCGAQMYCINKTCKEVPLMGYNCNATIKCRGNGICNNLGNCHCIPDYTPPDCELHIGSPGGSIDDGYDHKSYTTFTKKGYNTHQNWLILSFYIFLPFFIIFTIMIMKRNEMRKSCNKESVEYEGHSAIVPEHYDMDY", "length": 727, "header": "tr|F1MJ60-1|F1MJ60_BOVIN Isoform 1 of ADAM metallopeptidase domain 18 OS=Bos taurus OX=9913 GN=ADAM18 PE=4 SV=4 CANONICAL=F1MJ60-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPW9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPW9/entry", 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"MFLLLALLAALGGLLASQDSEGMFLYVTVPQKISSNESEDWEKQTPYTLHLRKHSFVSQNFLVYTYNETGSLHSESSYFKMPCHYQGYIAGFPNSVVTLSICSGLRGFLQFENISYGIEPLEFSARFEHIIYQVKNDHPDKPMFAENYSNIWQKDQSYTIHLSSQEKTFSELLPQYLEMHIIVEKALYDYMGSEMMAVTQKIIQIIGLVNAMFSQFKLTVILSYLELWSDKNQISTIGDADDLLQRFLAWKQDYLILRPHDVTLLLIYRKQPKYVGATFPGTICNRSYDADVAVYPGTITLEGFSVIIAQLLGLKIGLAYDDIQECSCPTAKCIMNHEAVLSSGVKIFSNCSMHEYRYFVSTFEAQCLQKFSILKPFYQNQSVCGNGILEAHEECDCGSEQECQFKNCCDYNTCQLKGPVQCASGSCCTSKCEISVAGTPCRKSVDPECDFTEYCNGTSSNCVPDTYAMNGQLCRLGNAYCYNGRCQTTDNQCAKVFGKGAQGAPSACFEEVNSLPNSFGNCGFKNSQPLPCEQKDVLCGKLACVWPQNSTYRSDVRSAVYSYSQGLLCVTTASSVRSGGRDYTYVADGTVCGAQMYCINKTCKEVPLMGYNCNATIKCRGNGICNNLGNCHCIPDYTPPDCELHIGSPGGSIDDGYDHKSYTTFTKKGYNTHQNWLILSFYIFLPFFIIFTIMIMKRNEMRKSCNKESVEYEGHSAIVPEHYDMDY", "length": 727, "header": "tr|F1MJ60-1|F1MJ60_BOVIN Isoform 1 of ADAM metallopeptidase domain 18 OS=Bos taurus OX=9913 GN=ADAM18 PE=4 SV=4 CANONICAL=F1MJ60-1" }, "locus": { "chromosome": "27", "start_pos": 34968193, "end_pos": 34856810, "strand": "-", "evidence": [ { 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], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MJ60", "url": "https://www.uniprot.org/uniprotkb/F1MJ60" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" }, { "start_pos": 380, "end_pos": 382, "annotation": "n_glycosylation_sequon" }, { "start_pos": 456, "end_pos": 458, "annotation": "n_glycosylation_sequon" }, { "start_pos": 549, "end_pos": 551, "annotation": "n_glycosylation_sequon" }, { "start_pos": 600, "end_pos": 602, "annotation": "n_glycosylation_sequon" }, { 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"end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJ60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ60" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 609, "end_pos": 643, "start_aa": "Met", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJ60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ60" }, { "id": "PS50215", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50215" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M12B", "eco_id": "ECO_0000259", "start_pos": 175, "end_pos": 372, "start_aa": "Gln", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 147, "end_pos": 149 }, { "start_pos": 285, "end_pos": 287 }, { "start_pos": 350, "end_pos": 352 }, { "start_pos": 36, "end_pos": 38 }, { "start_pos": 380, "end_pos": 382 }, { "start_pos": 456, "end_pos": 458 }, { "start_pos": 549, "end_pos": 551 }, { "start_pos": 600, "end_pos": 602 }, { "start_pos": 614, "end_pos": 616 }, { "start_pos": 67, "end_pos": 69 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MBQ1-1", "uniprot_ac": "F1MBQ1", "uniprot_id": "F1MBQ1_BOVIN", "mass": { "chemical_mass": 75965.0, "monoisotopic_mass": 75965.0 }, "refseq": { "ac": "XP_015317263", "name": "serine/threonine-protein phosphatase with EF-hands 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015317263" }, "gene_names": [ { "name": "PPEF1", "type": "recommended", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] }, { "name": "PPEF1", "type": "synonym", "evidence": [ { "id": "XP_015317263", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015317263" } ] } ], "protein_names": [ { "name": "Serine/threonine-protein phosphatase with EF-hands", "type": "recommended", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.16", "type": "synonym", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1/entry#names_and_taxonomy" } ] }, { "name": "serine/threonine-protein phosphatase with EF-hands 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015317263", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015317263" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MBQ1", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PPEF1", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1", "locus": { "chromosome": "X", "start_pos": 124612354, "end_pos": 124736812, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009545", "url": "https://www.ensembl.org/id/ENSBTAG00000009545" } ] } } ], "crossref": [ { "id": "F1MBQ1", "url": "https://alphafold.ebi.ac.uk/entry/F1MBQ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009545", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009545", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07420", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07420", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23767", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23767", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504618", "url": "https://www.ncbi.nlm.nih.gov/gene/504618", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013235", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013235", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029052", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029052", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051134", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051134", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504618", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504618", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SHDNEIN", "url": "https://omabrowser.org/oma/group/SHDNEIN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MBQ1", "url": "https://www.orthodb.org/?gene=F1MBQ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45668", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45668", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45668:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45668:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00149", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00149", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08321", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08321", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2514859", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_015317263", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015317263", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "20629", "url": "https://www.rhea-db.org/rhea/20629", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47004", "url": "https://www.rhea-db.org/rhea/47004", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LSU6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSU6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSU6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSU6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBQ1", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBQ1-1", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNTPNLEDMGCGTSSATKDKKSEKALKAALVIQNWYRGYSARLKTRQRYALTIFQSIEYADEQGQLQLSNFFSFMLENYTNVPEKEPGLVTRLFGSSIQDKDRQDYLGLIEIPDSYCGPRLQFPLTFTDIDLLIEAFKQQQILHAYYVLEVLFETKKVLQQMPNFTHTNTSPSKEITICGDLHGKLDDLFLIFYKNGLPSVTNPYVFNGDFVDRGKNSMEILMILFVSFLVYPNDLHLNRGNHEDFMMNMRYGFTKEILHKYKLHGKKILQILEEVYTWLPIGTIIDNEVLVIHGGISESTDLNLLHRIERNKMRSVLMPPIPMDGDRAEKKNKLGTATVALGIRTSGSFSEQLTKQEWEQVIDILWSDPRGKRGCYPNTNRGGGCYFGPDITSKILNKYQLKMLVRSHECKPEGYEICHDGKVITVFSASNYYEEGSNRGAYIRMSSGTTPRFFQYQITKATCFRPLYQRVNAIESSAIRMLKERMISRKTDLIRAFQLQDRNKSGKLSMGQWAFSMENVLGLNLPWRSLSSHLVTTDKDGNIDYMSGFQDVHIQKPVKEVQSSLIETVYRYRSDLQIIFNIIDSDHSGLISMEEFRSMWRLFKSHYSVHIDDSQFDELAERMDLNKDGSIDFNEFLKAFYVVHKFDQLNKSDTKLA", "length": 658, "header": "tr|F1MBQ1-1|F1MBQ1_BOVIN Isoform 1 of Serine/threonine-protein phosphatase with EF-hands OS=Bos taurus OX=9913 GN=PPEF1 PE=3 SV=2 CANONICAL=F1MBQ1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSU6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSU6/entry", "sequence": { "sequence": "MNTPNLEDMGCGTSSATKDKKSEKALKAALVIQNWYRGYSARLKTRQRYALTIFQSIEYADEQGQLQLSNFFSFMLENYTNVPEKEPGLVTRLFGSSIQDKDRQDYLGLIEIPDSYCGPRLQFPLTFTDIDLLIEAFKQQQILHAYYVLEVLFETKKVLQQMPNFTHTNTSPSKEITICGDLHGKLDDLFLIFYKNGLPSVTNPYVFNGDFVDRGKNSMEILMILFVSFLVYPNDLHLNRGNHEDFMMNMRYGFTKEILHKYKMRSVLMPPIPMDGDRAEKKNKLGTATVALGIRTSGSFSEQLTKQEWEQVIDILWSDPRGKRGCYPNTNRGGGCYFGPDITSKILNKYQLKMLVRSHECKPEGYEICHDGKVITVFSASNYYEEGSNRGAYIRMSSGTTPRFFQYQITKATCFRPLYQRVNAIESSAIRMLKERMISRKTDLIRAFQLQDRNKSGKLSMGQWAFSMENVLGLNLPWRSLSSHLVTTDKDGNIDYMSGFQDVHIQKPVKEVQSSLIETVYRYRSDLQIIFNIIDSDHSGLISMEEFRSMWRLFKSHYSVHIDDSQFDELAERMDLNKDGSIDFNEFLKAFYVVHKFDQLNKSDTKLA", "length": 608, "header": "tr|A0A3Q1LSU6-1|F1MBQ1_BOVIN Computationally mapped isoform of Serine/threonine-protein phosphatase with EF-hands OS=Bos taurus OX=9913 GN=PPEF1 PE=3 SV=1 CANONICAL=F1MBQ1-1" }, "locus": { "chromosome": "X", "start_pos": 124729759, "end_pos": 124612767, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068795.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068795.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060353.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060353.2" } ] } }, { "isoform_ac": "F1MBQ1-1", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1/entry", "sequence": { "sequence": "MNTPNLEDMGCGTSSATKDKKSEKALKAALVIQNWYRGYSARLKTRQRYALTIFQSIEYADEQGQLQLSNFFSFMLENYTNVPEKEPGLVTRLFGSSIQDKDRQDYLGLIEIPDSYCGPRLQFPLTFTDIDLLIEAFKQQQILHAYYVLEVLFETKKVLQQMPNFTHTNTSPSKEITICGDLHGKLDDLFLIFYKNGLPSVTNPYVFNGDFVDRGKNSMEILMILFVSFLVYPNDLHLNRGNHEDFMMNMRYGFTKEILHKYKLHGKKILQILEEVYTWLPIGTIIDNEVLVIHGGISESTDLNLLHRIERNKMRSVLMPPIPMDGDRAEKKNKLGTATVALGIRTSGSFSEQLTKQEWEQVIDILWSDPRGKRGCYPNTNRGGGCYFGPDITSKILNKYQLKMLVRSHECKPEGYEICHDGKVITVFSASNYYEEGSNRGAYIRMSSGTTPRFFQYQITKATCFRPLYQRVNAIESSAIRMLKERMISRKTDLIRAFQLQDRNKSGKLSMGQWAFSMENVLGLNLPWRSLSSHLVTTDKDGNIDYMSGFQDVHIQKPVKEVQSSLIETVYRYRSDLQIIFNIIDSDHSGLISMEEFRSMWRLFKSHYSVHIDDSQFDELAERMDLNKDGSIDFNEFLKAFYVVHKFDQLNKSDTKLA", "length": 658, "header": "tr|F1MBQ1-1|F1MBQ1_BOVIN Isoform 1 of Serine/threonine-protein phosphatase with EF-hands OS=Bos taurus OX=9913 GN=PPEF1 PE=3 SV=2 CANONICAL=F1MBQ1-1" }, "locus": { "chromosome": "X", "start_pos": 124729759, "end_pos": 124612767, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012557.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012557.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012557.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012557.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:504618", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504618", "resource": "KEGG Pathway" }, { "id": "R-BTA-2514859", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2514859", "resource": "Reactome", "description": "Inactivation, recovery and regulation of the phototransduction cascade" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1UWE5-1", "protein_name": "Serine/threonine-protein phosphatase", "gene_name": "PPEF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGCGTSSSAKDRKSENALKAALVIQNWYRGYSARLKARQRYALTIFQSIEYADEQGQLQLSNFFSFMLENYTHVHEKDRELVTRLFSGSIQDKKDRQDYLGLIDVPDSYSGPRLQFPLTFTDIDLLIEAFKQQQILHAYYVLEVLFETKKVLQQMPNFTHTKTSPSKEITICGDLHGKLDDLFLIFYKNGLPSVSNPYVFNGDFVDRGKNSMEILMILFVSFLVYPNDLHLNRGNHEDFMMNMRYGFTKEILHKYKLHGKKILQILEDVYTWLPIGTIIDNEVLVIHGGISESTDLNLLHRIERNKMKSVLMPPIPLDGDRVSEKKNKVGPTITAQGIRADGSASEQLTKHEWEQVITVFSASNYYEEGSNRGAYIRMSSGTTPRFFQYQVTRATCLRPLYQRVNAIESSAIRMLKERMISRKTDLIRAFQLQDRNKSGKLSMGQWAFSMENVLGLNLPWRSLSSHLVTTDKDGNIDYMSTFQDLHIQKPVKEVQSSLIETVYRYRSDLQIIFNIIDSDHSGLISMEEFRSMWKLFKSHYSVHIDDSQFDELAERMDLNKDGSIDFNEFLKAFYVVHKFDKLSKSDTKLA", "length": 590 }, "evidence": [ { "id": "F1MBQ1", "url": "https://omabrowser.org/oma/group/F1MBQ1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M9QHP8-1", "protein_name": "Serine/threonine-protein phosphatase with EF-hands", "gene_name": "ppef1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGCGTSIAIENQTRPSETDGSIKQSNPALTIKAAILIQRWYRRYVAHLEMRRRYTWNIFQSIEYAGEQDQLQLSSFFTFMLDNFTQINGNGPDLISHLLDSVVDPLTEEVRQLKYEQIMVPESYSGPRLSFPLSVTDTNALLSAFKEEQTLHGKYVLQLLYETKKFLKQMPNVIYLSTSYAKEITICGDLHGRLDDLLLIFYKNGLPSAENPYIFNGDFVDRGKKSTEIIIILFAFVLLYPDHMHLNRGNHEDHIMNLRYGFTREVMQKYKTHGREILQLLQDVFSLLPVATVIDNKVLIVHGGISDKTDLDFLSTVERHKVKSALRLPKRSTDHLTVRSCSRSSSRNRGRNSRSSSRHSSRSRRKKLSKQGSRSSSSSSSSSSSSSMCSPRVSAKNTPRRPPPSPTDMLQVPFLDSFVSLEPPELPREELEWQQVVDILWSDPKHQNGCSPNSFRGGGCYFGPDVTQTLLQKHGLCLLIRSHECKQEGYELCHNGQVITIFSASNYYEEGSNRGAYVKLGPELVPRFFQYQVSRSTRKLTLHQRVRVAEGSALRALKEKLYAHRSELMAAFQQYDINNTGRISTSEWAQVVESVLRLDLPWRTLRPRLARLGTDGNVEYESCFEDISPGEPIPPVTPNLAETLYRYRTDLEIIFNIIDKDHSGQISIEEFRQTWKLFSSHLGVAVNDQTIDDMARSIDFNKDGSIDFTEFLEAFRVVHKLDVKEQQQG", "length": 729 }, "evidence": [ { "id": "F1MBQ1", "url": "https://omabrowser.org/oma/group/F1MBQ1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E1BTX9-1", "protein_name": "Serine/threonine-protein phosphatase", "gene_name": "PPEF1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MECTISTMGCNASAHYSKHKYNETAIKATVLIQRWYRCKRAQLEVRRRYSLTIFQSIEYADEQEQTQLSNFFTFMLEHCVHRGEVARTSTGSDVSPGTDSYVIKYEKIDVPDSYRGPRLSFPLDISHAKTLLNALKDRQLLHARYVLQLLCETRRVLKEKPNITHVSVSYFKEITICGDLHGNLDDLLLVFHKNGLPSENNPYVFNGDFVDRGKNSMEILIILFVFLLIYPNDFHLNRGNHEDYILNMKYGFAKEVLKKYKDHGKTILHHLQDIFSWLPLATIVNNKVLIVHGGISDTTDLDSLNLLERNKLKTLMKTRKLETDKKNQEEHSELTEKERKQVLDILWSDPNKQHGCTPNQRRGGGCYFGPDTTDQLLKRYNLKMLIRSHEFKPDGYDLTHNGKVITIFSASNYYEAGSNRGAYIRMNPDLVPHFIQYQVCACTDKKKNWERVKTIEQSALQNLQERIFVHKRKLMDTFAKCDCKNTGRISISDWAAVMESVLQLKLPWRMLRSRLVKTDPDGKVDYMSCFCYMDTARPMHQVQPTLVETLCKYRRDLQMIFNVLDEDRSGLISPNEFRKMWKIFSSYLGIHSHDEAVDKLAQSIDFNKDGNIDFSEFLEAFHVVHQLENKAA", "length": 632 }, "evidence": [ { "id": "F1MBQ1", "url": "https://omabrowser.org/oma/group/F1MBQ1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O14829-1", "protein_name": "Serine/threonine-protein phosphatase with EF-hands 1", "gene_name": "PPEF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGCSSSSTKTRRSDTSLRAALIIQNWYRGYKARLKARQHYALTIFQSIEYADEQGQMQLSTFFSFMLENYTHIHKEELELRNQSLESEQDMRDRWDYVDSIDVPDSYNGPRLQFPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLFLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLIPPTETNRDHDTDSKHNKVGVTFNAHGRIKTNGSPTEHLTEHEWEQIIDILWSDPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIKLCSGTTPRFFQYQVTKATCFQPLRQRVDTMENSAIKILRERVISRKSDLTRAFQLQDHRKSGKLSVSQWAFCMENILGLNLPWRSLSSNLVNIDQNGNVEYMSSFQNIRIEKPVQEAHSTLVETLYRYRSDLEIIFNAIDTDHSGLISVEEFRAMWKLFSSHYNVHIDDSQVNKLANIMDLNKDGSIDFNEFLKAFYVVHRYEDLMKPDVTNLG", "length": 653 }, "evidence": [ { "id": "F1MBQ1", "url": "https://omabrowser.org/oma/group/F1MBQ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O35655-1", "protein_name": "Serine/threonine-protein phosphatase with EF-hands 1", "gene_name": "Ppef1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGCGTSSKKGNKSKKVIKAALVIQNWYRRYRARLRVRQHYALAIFQSIEYSDEQGQMQLSSFFSFMLENYTKTNNEDSALVTRIFDNTRRESQIKDRDDFLGLIEVPDSYDGPRLQFPLTFTDIHILLQAFKQQQILHAHYVLEVLFEARKVLKQMPNFSHVKTFPAKEITICGDLHGKLDDLMLIFYKNGLPSENNPYVFNGDFVDRGNNSMEILMILLVCFLVYPSDLHLNRGNHEDFMMNLRYGFTKEILQKYKLHGRKILQVLEEVYTWLPIGTIIDNEILVIHGGISESTDLNTLHQLQRNKMKSVLMPPVLGNQETGEKRNKSASNYVEPRKVEPDKTPSEDLTKQEWEQIVDILWSDPRGKKGCYPNTSRGGGCYFGPDVTSKVLSKNQLKMLIRSHECKPDGYEVSHDGKVITVFSASNYYEEGSNRGAYIRLSYGTMPQFFQYQVTSTSCLNPLHQRMNAMESSAFKILKEKMISRKTDLINAFELRDHSRSGRISLAEWAFSMENILGLNLPWRSLSSHLVTIDSSGSVDYMSSFDDIRIEKPTKDMKSNLTETMYRYRSDLKIIFNIIDSDQSGLISMDEFRTMWKLFNAHYKAHIDDSQIDELASIVDFNKDGNIDFNEFLKAFYVVHKYDKPGTSLA", "length": 650 }, "evidence": [ { "id": "F1MBQ1", "url": "https://omabrowser.org/oma/group/F1MBQ1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q3SWT6-1", "protein_name": "Serine/threonine-protein phosphatase with EF-hands 1", "gene_name": "Ppef1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGCGSSSKKGKKSEKVVRAALIIQNWYRRYRARLSARQHYALAIFQSIEYADEQGQMQLSSFFSFMLENYTNTHKEDSALVSRLFENTRLESKDREEYVGLIDVPDSYDGPRLQFPLTFTDINLLLQAFKQQQTLHAHYVLEVLFEARKILKQMPNFTRIQTFPAKEITICGDLHGKLDDLMLIFYKNGLPSEKNPYVFNGDFVDRGNNSMEILMILLVSFLVYPTDLHLNRGNHEDFMMNLRYGFTKEILQKYKLHGKKILQVLEELYTWLPIGTIIDNEILVIHGGISESTDLNILQQLQRNKMKSVLMPPMSTNQECNIKKNKAGPSEQSASEQLTKLEWEQIIDLLWSDPRGKKGCYPNTSRGGGCYFGPDVTSKVLNKNQLKMVIRSHECKPDGYEICHDGKVITVFSASNYYEEGSNRGAYIRLSYGTSPQFFQYQVTSTSCLNPLYQRVNAMEFSAFRILKERMIARKTDLINAFELRDHSRTGKISLAQWAFSMESILGLNLPWRSLSSHLVSTDSSGSVDYMSSFDDIHIEKPMKDMKSDLIETMYRYRSDLKIIFNIIDTDQSGLISMDEFRTMWKLFNAHYKVHIDDSQIDELASTMDSNKDGNIDFNEFLRAFYVVHKYETPESPLNK", "length": 640 }, "evidence": [ { "id": "F1MBQ1", "url": "https://omabrowser.org/oma/group/F1MBQ1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of stimulus involved in sensory perception", "id": "GO:0050906", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050906", "evidence": [ { "database": "UniProtKB", "id": "F1MBQ1", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "F1MBQ1", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ], "pmid": "" }, { "name": "manganese ion binding", "id": "GO:0030145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030145", "evidence": [ { "database": "UniProtKB", "id": "F1MBQ1", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MBQ1", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ], "pmid": "" }, { "name": "protein serine/threonine phosphatase activity", "id": "GO:0004722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", "evidence": [ { "database": "UniProtKB", "id": "F1MBQ1", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MBQ1", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MBQ1", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 504, "end_pos": 506, "annotation": "n_glycosylation_sequon" }, { "start_pos": 651, "end_pos": 653, "annotation": "n_glycosylation_sequon" }, { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20629", "name": "", "equation": "O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BEW5-1", "A0AAA9TV14-1", "A0AAA9S745-1", "A0A3Q1MV48-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "F1MBQ1-1", "A0AAA9RTM1-1", "A0AAF6YJP2-1", "P48452-1", "F1MI99-1", "G3N3B3-1", "O62830-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "A6H772-1", "O62829-1", "P61287-1", "A0AAA9U0H6-1", "Q3ZBF9-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q0P594-1", "Q1RMV9-1", "Q2KJ36-1", "Q2PC20-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0A3Q1N224-1", "E1BMD4-1", "A0AAF6DLF7-1", "F1N580-1", "F1MQM7-1", "F1MW60-1", "F1N719-1", "E1BF95-1", "E1BIE7-1", "F1MEZ2-1", "F1MM08-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "20629", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20629" } ] }, { "id": "47004", "name": "", "equation": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6DLF7-1", "F1MI92-1", "A0A3Q1MV48-1", "E1BEW5-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "A0ABI0P1A3-1", "F1MBQ1-1", "A0AAA9RTM1-1", "G3N3B3-1", "A0AAF6YJP2-1", "P48452-1", "O62829-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "Q0P594-1", "A6H772-1", "O62830-1", "P61287-1", "A0AAA9U0H6-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q1RMV9-1", "Q2KJ36-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "E1BIZ2-1", "F1MI99-1", "F1MP34-1", "F1MEZ2-1", "F1MQM7-1", "F1MM08-1", "F1N719-1", "A0AAA9T455-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0AAA9TV14-1", "A0AAA9S745-1", "F1N580-1", "E1BMD4-1", "E1BF95-1", "E1BIE7-1", "A0A3Q1N224-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "47004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47004" } ] }, { "id": "R-BTA-74948", "name": "PP2A dephosphorylates p-RHO to RHO", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, photoreceptor disc membrane", "input_participant_list": [ "R-BTA-2581504" ], "output_participant_list": [], "enzyme_list": [ "F1MBQ1-1" ], "evidence": [ { "id": "R-BTA-74948", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-74948" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-2581504", "participant_name": "phospho-p-S334,338,343-RHO [photoreceptor disc membrane]", "crossref": [ { "id": "P02699", "database": "UniProt", "url": "" }, { "id": "2HPY", "database": "PDB", "url": "" }, { "id": "5TE5", "database": "PDB", "url": "" }, { "id": "3PXO", "database": "PDB", "url": "" }, { "id": "1EDS", "database": "PDB", "url": "" }, { "id": "7MT8", "database": "PDB", "url": "" }, { "id": "5TE3", "database": "PDB", "url": "" }, { "id": "1HZX", "database": "PDB", "url": "" }, { "id": "1JFP", "database": "PDB", "url": "" }, { "id": "6NWE", "database": "PDB", "url": "" }, { "id": "3C9L", "database": "PDB", "url": "" }, { "id": "4PXF", "database": "PDB", "url": "" }, { "id": "7ZBC", "database": "PDB", "url": "" }, { "id": "5DYS", "database": "PDB", "url": "" }, { "id": "7MT9", "database": "PDB", "url": "" }, { "id": "5EN0", "database": "PDB", "url": "" }, { "id": "8A6C", "database": "PDB", "url": "" }, { "id": "4J4Q", "database": "PDB", "url": "" }, { "id": "1L9H", "database": "PDB", "url": "" }, { "id": "2X72", "database": "PDB", "url": "" }, { "id": "2G87", "database": "PDB", "url": "" }, { "id": "ENSBTAT00000001730", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000001730", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000001310", "database": "ENSEMBL", "url": "" }, { "id": "8RJB", "database": "PDB", "url": "" }, { "id": "1EDX", "database": "PDB", "url": "" }, { "id": "6FK8", "database": "PDB", "url": "" }, { "id": "3C9M", "database": "PDB", "url": "" }, { "id": "6FKD", "database": "PDB", "url": "" }, { "id": "6OFJ", "database": "PDB", "url": "" }, { "id": "3PQR", "database": "PDB", "url": "" }, { "id": "3DQB", "database": "PDB", "url": "" }, { "id": "8P13", "database": "PDB", "url": "" }, { "id": "1LN6", "database": "PDB", "url": "" }, { "id": "4BEY", "database": "PDB", "url": "" }, { "id": "3OAX", "database": "PDB", "url": "" }, { "id": "1EDV", "database": "PDB", "url": "" }, { "id": "6PEL", "database": "PDB", "url": "" }, { "id": "1VQX", "database": "PDB", "url": "" }, { "id": "8A6D", "database": "PDB", "url": "" }, { "id": "8FCZ", "database": "PDB", "url": "" }, { "id": "6OY9", "database": "PDB", "url": "" }, { "id": "4BEZ", "database": "PDB", "url": "" }, { "id": "7ZBE", "database": "PDB", "url": "" }, { "id": "6FK9", "database": "PDB", "url": "" }, { "id": "6FKC", "database": "PDB", "url": "" }, { "id": "5WKT", "database": "PDB", "url": "" }, { "id": "4X1H", "database": "PDB", "url": "" }, { "id": "6PH7", "database": "PDB", "url": "" }, { "id": "8A6E", "database": "PDB", "url": "" }, { "id": "6FKB", "database": "PDB", "url": "" }, { "id": "1NZS", "database": "PDB", "url": "" }, { "id": "8P12", "database": "PDB", "url": "" }, { "id": "8RJD", "database": "PDB", "url": "" }, { "id": "1EDW", "database": "PDB", "url": "" }, { "id": "6QNO", "database": "PDB", "url": "" }, { "id": "6FK7", "database": "PDB", "url": "" }, { "id": "6OYA", "database": "PDB", "url": "" }, { "id": "8RJC", "database": "PDB", "url": "" }, { "id": "6FKA", "database": "PDB", "url": "" }, { "id": "3CAP", "database": "PDB", "url": "" }, { "id": "6FK6", "database": "PDB", "url": "" }, { "id": "6FUF", "database": "PDB", "url": "" }, { "id": "4A4M", "database": "PDB", "url": "" }, { "id": "6PGS", "database": "PDB", "url": "" }, { "id": "1U19", "database": "PDB", "url": "" }, { "id": "2I35", "database": "PDB", "url": "" }, { "id": "2I36", "database": "PDB", "url": "" }, { "id": "8FD1", "database": "PDB", "url": "" }, { "id": "1F88", "database": "PDB", "url": "" }, { "id": "8FD0", "database": "PDB", "url": "" }, { "id": "7MTB", "database": "PDB", "url": "" }, { "id": "2J4Y", "database": "PDB", "url": "" }, { "id": "1FDF", "database": "PDB", "url": "" }, { "id": "2PED", "database": "PDB", "url": "" }, { "id": "7MTA", "database": "PDB", "url": "" }, { "id": "2I37", "database": "PDB", "url": "" }, { "id": "1GZM", "database": "PDB", "url": "" }, { "id": "P02699", "database": "PRO", "url": "" }, { "id": "NP_001014890.1", "database": "RefSeq", "url": "" }, { "id": "33942", "database": "VGNC", "url": "" }, { "id": "OPSD_BOVIN", "database": "ZINC - Substances", "url": "" }, { "id": "P02699", "database": "ZINC target", "url": "" }, { "id": "8P15", "database": "PDB", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + 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] } ] }, { "uniprot_ac": "A0AAA9SWY4", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] } ] }, { "uniprot_ac": "A0AAA9T455", "gene_name": "CDKN3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": 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"activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] } ] }, { "uniprot_ac": "E1BAB2", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] } ] }, { "uniprot_ac": "E1BBD9", "gene_name": "LOC112445820", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] } ] }, { "uniprot_ac": "E1BEW5", "gene_name": "PPTC7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] } ] }, { "uniprot_ac": "E1BF95", "gene_name": "PPM1F", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] } ] }, { "uniprot_ac": "E1BIE7", "gene_name": "PGAM5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] } ] }, { "uniprot_ac": "E1BIZ2", "gene_name": "SSH1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] } ] }, { "uniprot_ac": "E1BMD4", "gene_name": "PHLPP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] } ] }, { "uniprot_ac": "F1MBQ1", "gene_name": "PPEF1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MI92", "gene_name": "SSH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MW60", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1N580", "gene_name": "PPM1E", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] } ] }, { "uniprot_ac": "F1N719", "gene_name": "PPP5C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] } ] }, { "uniprot_ac": "F6RRD7", "gene_name": "RPAP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] } ] }, { "uniprot_ac": "G3N3B3", "gene_name": "PPM1N", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] } ] }, { "uniprot_ac": "O62829", "gene_name": "PPM1A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] } ] }, { "uniprot_ac": "O62830", "gene_name": "PPM1B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P48452", "gene_name": "PPP3CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] } ] }, { "uniprot_ac": "P61287", "gene_name": "PPP1CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] } ] }, { "uniprot_ac": "P67774", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] } ] }, { "uniprot_ac": "P79126", "gene_name": "PPM1G", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { 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"length": 998, "header": "tr|F1MDF8-1|F1MDF8_BOVIN Isoform 1 of Protein tyrosine phosphatase receptor type N2 OS=Bos taurus OX=9913 GN=PTPRN2 PE=3 SV=3 CANONICAL=F1MDF8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWC4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWC4/entry", "sequence": { "sequence": 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"tr|A0A3Q1LWC4-1|F1MDF8_BOVIN Computationally mapped isoform of Protein tyrosine phosphatase receptor type N2 OS=Bos taurus OX=9913 GN=PTPRN2 PE=3 SV=2 CANONICAL=F1MDF8-1" }, "locus": { "chromosome": "4", "start_pos": 119214331, "end_pos": 118733682, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077476.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077476.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061518.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061518.2" } ] } }, { "isoform_ac": "F1MDF8-1", "url": "https://www.uniprot.org/uniprotkb/F1MDF8/entry", "sequence": { "sequence": "MGPPLALLLLLLLPRAPPVAPAPAPAPRTRPLPGLLGCLFEDGLCRPAETCVNDGVFGRCQEFPAVDALRYEVSPGVLQHLTATLQKLSRTGLTWQDDSTQRVMARELASLPQTHPRHPEASSPARSSKQSVPDERSLSLEGGVLAEALQRYLPYLEALSQAAAAADALPGPELDRPPAQGEDPLADSVLTFVAQTSALTYAPAARADLAGGRPLRTLRRLQPDELSPKVAGGVDRQRLVAALGAYAARKAPAPARDGDPAPRGLVRAPWRAPRVLSAPAAPQRWPSPTDPRDAPITDDEARVQMLLKDLQKRPAGVDGLSALDVDEVVRALAIAVPSGGVAGAPGAAGRAGRRGAEVNGAGAALHRDRVPESRLRDSDEGLYREVNRLGVQLGDLLQGPGSPFLPAAPHLTEPFKTESKKGDDAEASLSSEEEHAGVENVRSQTYSKELLQRPPQARPGPGRAPQEALRLGAGAQVPPGPGLRLQVQPPEEEYGYILMENDSLSLDEGTQALEGVARLLEVPAGVFTDVEVEGPAVTFRVRANAQNVTAAAAAKAAADNRDKLQTMSGLRVLQAGVGSRSRIKLLPHQAAREDSTKFVVLTLVSIVVIVGVLLASGVIYCLRHNSHYRLKEKLSGLVGDPGPDATDAYQELCRQRMAVRTTERPEAAHTSRVSSVSSQFSDGPMPSPSARSSTSSWSEEPVQPNMDISTGHMVLAYMEDHLKNKNRLEKEWEALCAYQAEPSSSLVAQREENLPKNRCPAVLTYDHSRIRLKSENSHSSSDYINASPIMDHDPRKPAYIATQGPLPSTVADFWQMVWESGCVVVVMLTPLAENGVRQCYRYWPDEGSSLYHIYEVHLVSEHIWCEDFLVRSFYLKNLQTSETRTVTQFHFLSWYDQGVPSSTRSLLDFRRKVNKCFRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKAFPQ", "length": 998, "header": "tr|F1MDF8-1|F1MDF8_BOVIN Isoform 1 of Protein tyrosine phosphatase receptor type N2 OS=Bos taurus OX=9913 GN=PTPRN2 PE=3 SV=3 CANONICAL=F1MDF8-1" }, "locus": { "chromosome": "4", "start_pos": 119330001, "end_pos": 118733682, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055262.3", "url": "https://www.ensembl.org/id/ENSBTAT00000055262.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050785.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050785.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 289, "start_aa": "Thr", "end_pos": 289, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr289", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:616515", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616515", "resource": "KEGG Pathway" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "secretory granule", "id": "GO:0030141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030141", "evidence": [ { "database": "UniProtKB", "id": "F1MDF8", "url": "https://www.uniprot.org/uniprotkb/F1MDF8" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1MDF8", "url": "https://www.uniprot.org/uniprotkb/F1MDF8" } ], "pmid": "" }, { "name": "transport vesicle membrane", "id": "GO:0030658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030658", "evidence": [ { "database": "UniProtKB", "id": "F1MDF8", "url": "https://www.uniprot.org/uniprotkb/F1MDF8" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "F1MDF8", "url": "https://www.uniprot.org/uniprotkb/F1MDF8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of secretion", "id": "GO:0051046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051046", "evidence": [ { "database": "UniProtKB", "id": "F1MDF8", "url": "https://www.uniprot.org/uniprotkb/F1MDF8" } ], "pmid": "" }, { "name": "insulin secretion involved in cellular response to glucose stimulus", "id": "GO:0035773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035773", "evidence": [ { "database": "UniProtKB", "id": "F1MDF8", "url": "https://www.uniprot.org/uniprotkb/F1MDF8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "F1MDF8", "url": "https://www.uniprot.org/uniprotkb/F1MDF8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 501, "end_pos": 503, "annotation": "n_glycosylation_sequon" }, { "start_pos": 547, "end_pos": 549, "annotation": "n_glycosylation_sequon" }, { "start_pos": 785, "end_pos": 787, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MDF8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 998, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MDF8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MDF8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MDF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF8" }, { "id": "PS50056", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50056" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine specific protein phosphatases", "eco_id": "ECO_0000259", "start_pos": 907, "end_pos": 979, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MDF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF8" }, { "id": "PS50055", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50055" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine-protein phosphatase", "eco_id": "ECO_0000259", "start_pos": 728, "end_pos": 988, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 289 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 501, "end_pos": 503 }, { "start_pos": 547, "end_pos": 549 }, { "start_pos": 785, "end_pos": 787 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"categories": [ "Protein Classification" ] }, { "id": "IPR016130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NMGDTYA", "url": "https://omabrowser.org/oma/group/NMGDTYA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LX35", "url": "https://www.orthodb.org/?gene=A0A3Q1LX35", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MDF1", "url": "https://www.orthodb.org/?gene=F1MDF1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45983", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45983", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45983:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45983:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00102", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00102", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8863795", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8863795", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001417640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001417640", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10684", "url": "https://www.rhea-db.org/rhea/10684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LX35", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LX35-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX35-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDF1", "url": "https://www.uniprot.org/uniprotkb/F1MDF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDF1-1", "url": "https://www.uniprot.org/uniprotkb/F1MDF1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRSLDAARSFLEQLEALGGRHGVVFAGEFSDIRARSAAWKTESVRSTEAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHGDYINGNFIRGTDGSQAYIATQGPLPHTLLDFWRLIWEFGVKVILMACQEMENGRKKCERYWALQQEPLQIGPFCITLTRDMWLNPDIKLRILQVTFQKESRSVFQLQYMSWPDRGVPSNPDNVLAMVEKARHLQGSGPNPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPNFSLFSVVLEIRKQRPLAIQTEEQYRFLYHTVSQMFLSAIQNASPHYQNLKENCVPLYDDALSLWTSQNLNAIARPSSGVLRSISVLGPPALSMADTYAVVQKRAAPAGTGAGAGARARGTEDTPLYSQVKPRAWRHQALSEDARGAQQGRVPVDESLAGPGAYEDVADRAQTGGLGFNLRIGRPKGPRDPPAEWTRV", "length": 454, "header": "tr|F1MDF1-1|F1MDF1_BOVIN Isoform 1 of protein-tyrosine-phosphatase OS=Bos taurus OX=9913 GN=PTPN18 PE=3 SV=2 CANONICAL=F1MDF1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LX35-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LX35/entry", "sequence": { "sequence": "MSRSLDAARSFLEQLEALGGRHGVVFAGEFSDIRARSAAWKTESVRSTEAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHGDYINGNFIRGTDGSQAYIATQGPLPHTLLDFWRLIWEFGVKVILMACQEMENGRKKCERYWALQQEPLQIGPFCITLTRDMWLNPDIKLRILQVTFQKESRSVFQLQYMSWPDRGVPSNPDNVLAMVEKARHLQGSGPNPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPNFSLFSVVLEIRKQRPLAIQTENCVPLYDDALSLWTSQNLNAIARPSSGVLRSISVLGPPALSMADTYAVVQKRAAPAGTGAGAGARARGTEDTPLYSQVKPRAWRHQALSEDARGAQQGRVPVDESLAGPGAYEDVADRAQTGGLGFNLRIGRPKGPRDPPAEWTRV", "length": 424, "header": "tr|A0A3Q1LX35-1|F1MDF1_BOVIN Computationally mapped isoform of protein-tyrosine-phosphatase OS=Bos taurus OX=9913 GN=PTPN18 PE=3 SV=2 CANONICAL=F1MDF1-1" }, "locus": { "chromosome": "2", "start_pos": 1352535, "end_pos": 1334043, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077372.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077372.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061785.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061785.2" } ] } }, { "isoform_ac": "F1MDF1-1", "url": "https://www.uniprot.org/uniprotkb/F1MDF1/entry", "sequence": { "sequence": "MSRSLDAARSFLEQLEALGGRHGVVFAGEFSDIRARSAAWKTESVRSTEAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHGDYINGNFIRGTDGSQAYIATQGPLPHTLLDFWRLIWEFGVKVILMACQEMENGRKKCERYWALQQEPLQIGPFCITLTRDMWLNPDIKLRILQVTFQKESRSVFQLQYMSWPDRGVPSNPDNVLAMVEKARHLQGSGPNPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPNFSLFSVVLEIRKQRPLAIQTEEQYRFLYHTVSQMFLSAIQNASPHYQNLKENCVPLYDDALSLWTSQNLNAIARPSSGVLRSISVLGPPALSMADTYAVVQKRAAPAGTGAGAGARARGTEDTPLYSQVKPRAWRHQALSEDARGAQQGRVPVDESLAGPGAYEDVADRAQTGGLGFNLRIGRPKGPRDPPAEWTRV", "length": 454, "header": "tr|F1MDF1-1|F1MDF1_BOVIN Isoform 1 of protein-tyrosine-phosphatase OS=Bos taurus OX=9913 GN=PTPN18 PE=3 SV=2 CANONICAL=F1MDF1-1" }, "locus": { "chromosome": "2", "start_pos": 1352535, "end_pos": 1334043, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015484.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015484.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015484.4", "url": "https://www.ensembl.org/id/ENSBTAP00000015484.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-8863795", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8863795", "resource": "Reactome", "description": "Downregulation of ERBB2 signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZN88-1", "protein_name": "protein-tyrosine-phosphatase", "gene_name": "Ptpn18", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRQSDLVRSFLEQQEARDHREGAILAREFSDIKARSVAWKTEGVCSTKAGSQQGNSKKNRYKDVVPYDETRVILSLLQEEGHGDYINANFIRGTDGSQAYIATQGPLPHTLLDFWRLVWEFGVKVILMACQETENGRRKCERYWAQEREPLQAGPFCITLTKETALTADITLRTLQVTFQKESRPVHQLQYMSWPDHGVPSSSDHILTMVEEARCLQGLGPGPLCVHCSAGCGRTGVLCAVDYVRQLLLTQTIPPNFSLFEVVLEMRKQRPAAVQTEEQYRFLYHTVAQLFSRTLQNNSPLYQNLKENRAPICKDSSSLRTSSALPATSRPLGGVLRSISVPGPPTLPMADTYAVVQKRGAPAGTGPGTRAPNSTDTPIYSQVAPRIQRPVSHTENAQGTTALGRVPADENPSGPDAYEEVTDGAQTGGLGFNLRIGRPKGPRDPPAEWTRV", "length": 453 }, "evidence": [ { "id": "F1MDF1", "url": "https://omabrowser.org/oma/group/F1MDF1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A9J7EZC9-1", "protein_name": "protein-tyrosine-phosphatase", "gene_name": "Ptpn18", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSRHLDLVRSFLEQLEARDLREEAILAREFSDIKARSVAWKTGGVCSTKVGSRLGNTKKNRYKDIVPYDETRVILSLLQEEGHGDYINANFIRGTDGSQAYIATQGPLPHTLLDFWRLVWEFRVKVILMACQETENGRKKCERYWAQKQEPLQIGPFCITLTKETPVNADIILRTLQVTFQKESRCVRQLQYMSWPDHGVPSSPDHILTMVEEAHRLQGAGPGPLCVHCSAGCGRTGVLCAVDYVRQLLLTQTIPPNFSLFDVVLEMRKQRPAAVQTEEQYRFLYHTVAQLFSRTLQKASPHYQNLKEGSFPRLSPHELTSAPTVTSIRSVASPPSPPDFLQNCAPICKDASSLRTSPALSATSRPPGGVLRSISVPGPPTLPMADTYAVVQKRGAPAGTGPGTRVPSSADAPIYSQVAPRSQRPVAHTEDARGTTPPGHVPADQNPPGPDAYEEVTNGAQTGALGFNLRIGRPKGPRDPPAEWTRV", "length": 487 }, "evidence": [ { "id": "F1MDF1", "url": "https://omabrowser.org/oma/group/F1MDF1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1RXX2-1", "protein_name": "protein-tyrosine-phosphatase", "gene_name": "PTPN18", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSHSLDAVRSFLEQLEARGGREGAVLAGEFSDIRAHSAAWKTDGVLSTEAGSRQENVRKNRYKDVLPYDQTRVILSLLQEEGHGDYINGNFIRGTDGSQAYIATQGPLPHTVLDFWRLIWEFGVKVILMACRETENGRKKCERYWAQEQEPLQIGPFCVTLIRETWLNADLTLRTLQVTFQKEARSVYQLQYMSWPDRGVPSNPDHVLVMVEEARRLQGSGPSPFCVHCSAGCGRTGVLCIVDYVRQLLLTQMIPPDFSLFNVVLNIRRQRPSAVQTEEQYRFLYHTVAQMFLAALQNASPHYQNLKENCAPLYDDALSLRTSQTLSAMARPSGGVLRSISVPGPPALAMADTYAVVQKRAAPAGTGAGAGSRARGEEEAPLYSQVMSRARRPQAHAEDARGALPGRVTADQNPDGPGAYEDVGNGAQTTGLGFNLRIGRPKGPRDPPAEWTRV", "length": 454 }, "evidence": [ { "id": "F1MDF1", "url": "https://omabrowser.org/oma/group/F1MDF1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q61152-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 18", "gene_name": "Ptpn18", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRHTDLVRSFLEQLEARDYREGAILAREFSDIKARSVAWKSEGVCSTKAGSRLGNTNKNRYKDVVAYDETRVILSLLQEEGHGDYINANFIRGIDGSQAYIATQGPLPHTLLDFWRLVWEFGVKVILMACQETENGRRKCERYWAREQEPLKAGPFCITLTKETTLNADITLRTLQVTFQKEFRSVHQLQYMSWPDHGVPSSSDHILTMVEEARCLQGLGPGPLCVHCSAGCGRTGVLCAVDYVRQLLLTQTIPPNFSLFQVVLEMRKQRPAAVQTEEQYRFLYHTVAQLFSRTLQDTSPHYQNLKENCAPICKEAFSLRTSSALPATSRPPGGVLRSISVPAPPTLPMADTYAVVQKRGASAGTGPGPRAPTSTDTPIYSQVAPRAQRPVAHTEDAQGTTALRRVPADQNSSGPDAYEEVTDGAQTGGLGFNLRIGRPKGPRDPPAEWTRV", "length": 453 }, "evidence": [ { "id": "F1MDF1", "url": "https://omabrowser.org/oma/group/F1MDF1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99952-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 18", "gene_name": "PTPN18", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRSLDSARSFLERLEARGGREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNASPHYQNIKENCAPLYDDALFLRTPQALLAIPRPPGGVLRSISVPGSPGHAMADTYAVVQKRGAPAGAGSGTQTGTGTGTGARSAEEAPLYSKVTPRAQRPGAHAEDARGTLPGRVPADQSPAGSGAYEDVAGGAQTGGLGFNLRIGRPKGPRDPPAEWTRV", "length": 460 }, "evidence": [ { "id": "F1MDF1", "url": "https://omabrowser.org/oma/group/F1MDF1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MDF1", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MDF1", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "non-membrane spanning protein tyrosine phosphatase activity", "id": "GO:0004726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004726", "evidence": [ { "database": "UniProtKB", "id": "F1MDF1", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ], "pmid": "" }, { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "F1MDF1", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1ME76-1", "F1MRH9-1", "A0AAF6DLF7-1", "A0AAA9S9Q3-1", "E1BFE2-1", "E1BL76-1", "G3MXS7-1", "A0A3Q1LUB1-1", "A0AAA9THG9-1", "F1N339-1", "F6RY99-1", "A0AAF6YUC8-1", "A0AAA9RTM1-1", "A0AAA9SMJ6-1", "A0A3Q1LZA9-1", "A7MBD1-1", "A5D7P0-1", "Q58DB6-1", "A0AAA9SEK4-1", "E1BDH9-1", "F1MGK4-1", "E1BIH4-1", "A0A3Q1M6K1-1", "E1BIU8-1", "A7MBJ4-1", "A6H730-1", "A0A3Q1MFX2-1", "A0AAA9U0H6-1", "A2VDT1-1", "E1BPU9-1", "P0C591-1", "P11064-1", "Q0IID7-1", "Q2KJ36-1", "Q2T9S4-1", "E1BPA0-1", "A0AAA9TAZ9-1", "Q5BIP9-1", "A0A3Q1M5K4-1", "F1MM08-1", "E1BJR7-1", "Q17QJ3-1", "Q17QM8-1", "F1MD22-1", "F1MI99-1", "F1MP34-1", "F1MGK5-1", "F1MEZ2-1", "F1MQM7-1", "E1BEZ8-1", "A0A3Q1M0B4-1", "A0AAA9S7W5-1", "A0A3Q1N8V6-1", "A0AAA9TFV5-1", "A0A3Q1MBB1-1", "F1MTZ3-1", "A0AAF6Z8C2-1", "F1MDF1-1", "A0AAA9T5N9-1", "E1BKT4-1", "A0A3Q1MH98-1", "F1N6L3-1", "F1MW70-1", "F1MXF2-1", "A0AAA9TWD1-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] }, { "id": "R-BTA-8864125", "name": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MDF1-1" ], "evidence": [ { "id": "R-BTA-8864125", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8864125" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUB1", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] } ] }, { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B4", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] } ] }, { "uniprot_ac": "A0A3Q1M5K4", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] } ] }, { "uniprot_ac": "A0A3Q1M6K1", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] } ] }, { "uniprot_ac": "A0A3Q1MBB1", "gene_name": "TNS2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] } ] }, { "uniprot_ac": "A0A3Q1MFX2", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1N8V6", "gene_name": "LOC101903026", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S7W5", "gene_name": "PTPRV", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] } ] }, { "uniprot_ac": "A0AAA9S9Q3", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] } ] }, { "uniprot_ac": "A0AAA9SEK4", "gene_name": "PTPRE", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] } ] }, { "uniprot_ac": "A0AAA9SMJ6", "gene_name": "PTPRH", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] } ] }, { "uniprot_ac": "A0AAA9T5N9", "gene_name": "", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] } ] }, { "uniprot_ac": "A0AAA9TAZ9", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] } ] }, { "uniprot_ac": "A0AAA9TFV5", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] } ] }, { "uniprot_ac": "A0AAA9THG9", "gene_name": "PTPRK", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] } ] }, { "uniprot_ac": "A0AAA9TWD1", "gene_name": "PTPN20", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YUC8", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] } ] }, { "uniprot_ac": "A0AAF6Z8C2", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ] }, { "uniprot_ac": "A2VDT1", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] } ] }, { "uniprot_ac": "A5D7P0", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "A7MBJ4", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] } ] }, { "uniprot_ac": "E1BDH9", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] } ] }, { "uniprot_ac": "E1BEZ8", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] } ] }, { "uniprot_ac": "E1BFE2", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] } ] }, { "uniprot_ac": "E1BIH4", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] } ] }, { "uniprot_ac": "E1BIU8", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] } ] }, { "uniprot_ac": "E1BJR7", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] } ] }, { "uniprot_ac": "E1BKT4", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] } ] }, { "uniprot_ac": "E1BL76", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] } ] }, { "uniprot_ac": "E1BPA0", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] } ] }, { "uniprot_ac": "E1BPU9", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] } ] }, { "uniprot_ac": "F1MD22", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] } ] }, { "uniprot_ac": "F1MDF1", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MGK4", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] } ] }, { "uniprot_ac": "F1MGK5", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MRH9", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] } ] }, { "uniprot_ac": "F1MTZ3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1MXF2", "gene_name": "MDP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] } ] }, { "uniprot_ac": "F1N339", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] } ] }, { "uniprot_ac": "F1N6L3", "gene_name": "PTPN22", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] } ] }, { "uniprot_ac": "F6RY99", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] } ] }, { "uniprot_ac": "G3MXS7", "gene_name": "PTPRG", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P11064", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q2KJ36", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] } ] }, { "uniprot_ac": "Q2T9S4", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "2-phosphoglycolate + H2O = glycolate + phosphate.", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] }, { "ec_number": "3.1.3.18", "activity": "", "evidence": [ { "id": "Q2T9S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9S4" } ] } ] }, { "uniprot_ac": "Q58DB6", "gene_name": "EYA2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q58DB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DB6" } ] } ] }, { "uniprot_ac": "Q5BIP9", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5BIP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIP9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5BIP9", "database": 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"OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 257, "end_pos": 259 }, { "start_pos": 298, "end_pos": 300 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPV7-1", "uniprot_ac": "E1BPV7", "uniprot_id": "E1BPV7_BOVIN", "mass": { "chemical_mass": 117620.0, "monoisotopic_mass": 117620.0 }, "refseq": {}, "gene_names": [ { "name": "COL28A1", "type": "recommended", "evidence": [ { "id": "E1BPV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPV7" } ] } ], "protein_names": [ { "name": "Collagen alpha-1(XXVIII) chain", "type": "recommended", "evidence": [ { "id": "E1BPV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPV7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": 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"common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COL28A1", "url": "https://www.uniprot.org/uniprotkb/E1BPV7", "locus": { "chromosome": "4", "start_pos": 15424636, "end_pos": 15607091, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024420", "url": "https://www.ensembl.org/id/ENSBTAG00000024420" } ] } } ], "crossref": [ { "id": "E1BPV7", "url": "https://alphafold.ebi.ac.uk/entry/E1BPV7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024420", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024420", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01450", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01450", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01472", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01472", "database": "CDD", "categories": [ "Protein 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"categories": [ "Protein Classification" ] }, { "id": "IPR050149", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050149", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24023:SF1082", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24023:SF1082", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37456", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37456", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR37456:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR37456:SF6", "database": "PANTHER", "categories": [ 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"UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPV7-1", "url": "https://www.uniprot.org/uniprotkb/E1BPV7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWNRRFVLYLLLLPAFMSQAIYGQRKKGSKTNLLARKNLQDSTCFIDLVFIVDSSESSKIFLFDKQKDFVGSLSDKIFQLTPVGSLKYDIKLAALQFSSSVQIDPPFSSWKDLQTFKQRVKSMNFIGQGTFSYYAIANATRLLKREGRKDGMKVAVLMTDGIDHPKNPDVQSISEDARTAGILFITIGLSAVVNETKLRLISGDLPSVPILLLNDSTLVDKIQDRLDILFEKKCERKICECEKGDPGDPGPPGDAQKGEPGERGPRGIPGYKGEKGERGECGKPGIKGDKGSPGPNGPKGPRGIQGIAGPPGDPGPKGFQGNKGEPGPPGPYGPPGAPGIGQQGVKGQRGQEGRTGPPGPTGVGEPGQTGPRGPEGPPGERGLPGEGLPGPKGEKGSQGAIGPQGEAGPSIKGDKGDMGPVGPQGLMGIPGIGSQGEQGIQGPIGPPGPQGPPGQGSPGPKGEVGQMGPTGPRGPVGLGVQGPKGEPGSIGLPGQPGVPGEDGAAGKKGEAGLPGARGPEGPPGKGQPGLKGDEGKKGSKGNQGQKGSQGPGGPKGDPGIMGPVGMPGISIPGPPGPKGDRGGPGMPGFKGEPGIAIRGPKGAQGPQGPVGAPGLKGDGYPGVPGPRGIPGPPGSRGLPGVGDTGAKGDPGVRGPPGPPGPRGIGTPGPKGDIGQKGLPGPPGSPGYGLQGIKGEQGPQGFPGPKGMTGHGLPGQKGEHGERGDVGKKGDKGEIGDPGPQGEQGLQGPKGDQGLTKEEIIKLIFEICGCGRKCKETPLELLFVIDSSESVGLKNFQIIKNFVKTLTDRVALDLATTRVGIINYSHKVEEVAHLTQFSSKDDLKRAVDNMQYLGEGTYTATALHAANRMFEAAKPGVKKVALVITDGQTDTRDEKNLTEVVKNASDINVEIFVIGVVKRNDPNFHIFHQEMNLIATDPDSEHVYLFDDFITLEDTLKQKLFTKSCEDFEAYLFHILGSSPLQPGFGISGEERHESTPEPQKEISESVHVSRAQDRENEPSERTWAASPATTPSPEAATIPGPLPRPPEDQAKGLETRAPSSTSNLEPENFVHKDPRCLEPLQPGNCSEYVVRWYYDKQVNSCARFWFSGCKGSGNRFNSEKECEEICIQG", "length": 1129, "header": "tr|E1BPV7-1|E1BPV7_BOVIN Isoform 1 of Collagen alpha-1(XXVIII) chain OS=Bos taurus OX=9913 GN=COL28A1 PE=3 SV=4 CANONICAL=E1BPV7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LYA4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYA4/entry", "sequence": { "sequence": "MWNRRFVLYLLLLPAFMSQAIYGQRKKGSKTNLLARKNLQDSTCFIDLVFIVDSSESSKIFLFDKQKDFVGSLSDKIFQLTPVGSLKYDIKLAALQFSSSVQIDPPFSSWKDLQTFKQRVKSMNFIGQGTFSYYAIANATRLLKREGRKDGMKVAVLMTDGIDHPKNPDVQSISEDARTAGILFITIGLSAVVNETKLRLISGDLPSVPILLLNDSTLVDKIQDRLDILFEKKCERKICECEKGDPGDPGPPGTHGNPGIKGERGPKGNPGDAQKGEPGERGPRGIPGYKGEKGERGECGKPGIKGDKGSPGPNGPKGPRGIQGIAGPPGDPGPKGFQGNKGEPGPPGPYGPPGAPGIGQQGVKGQRGQEGRTGPPGPTGVGEPGQTGPRGPEGPPGERGLPGEGLPGPKGEKGSQGAIGPQGEAGPSIKGDKGDMGPVGPQGLMGIPGIGSQGEQGIQGPIGPPGPQGPPGQGSPGPKGEVGQMGPTGPRGPVGLGVQGPKGEPGSIGLPGQPGVPGEDGAAGKKGEAGLPGARGPEGPPGKGQPGLKGDPGIMGPVGMPGISIPGPPGPKGDRGGPGMPGFKGEPGIAIRGPKGAQGPQGPVGAPGLKGDGYPGVPGPRGIPGPPGSRGLPGVGDTGAKGDPGVRGPPGPPGPRGIGTPGPKGDIGQKGLPGPPGSPGYGLQGIKGEQGPQGFPGPKGMTGHGLPGQKGEHGERGDVGKKGDKGEIGDPGPQGEQGLQGPKGDQGLTKEEIIKLIFEICGCGRKCKETPLELLFVIDSSESVGLKNFQIIKNFVKTLTDRVALDLATTRVGIINYSHKVEEVAHLTQFSSKDDLKRAVDNMQYLGEGTYTATALHAANRMFEAAKPGVKKVALVITDGQTDTRDEKNLTEVVKNASDINVEIFVIGVVKRNDPNFHIFHQEMNLIATDPDSEHVYLFDDFITLEDTLKQKLFTKSCEDFEAYLFHILGSSPLQPGFGISGEERHESTPEPQKEISESVHVSRAQDRENEPSERTWAASPATTPSPEAATIPGPLPRPPEDQAKGLETRAPSSTSNLEPENFVHKDPRCLEPLQPGNCSEYVVRWYYDKQVNSCARFWFSGCKGSGNRFNSEKECEEICIQG", "length": 1123, "header": "tr|A0A3Q1LYA4-1|E1BPV7_BOVIN Computationally mapped isoform of Collagen alpha-1(XXVIII) chain OS=Bos taurus OX=9913 GN=COL28A1 PE=3 SV=2 CANONICAL=E1BPV7-1" }, "locus": { "chromosome": "4", "start_pos": 15603392, "end_pos": 15425640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067622.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067622.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062228.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062228.2" } ] } }, { "isoform_ac": "A0AAA9SPL9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL9/entry", "sequence": { "sequence": "MWNRRFVLYLLLLPAFMSQAIYGQRKKGSKTNLLARKNLQDSTCFIDLVFIVDSSESSKIFLFDKQKDFVGSLSDKIFQLTPVGSLKYDIKLAALQFSSSVQIDPPFSSWKDLQTFKQRVKSMNFIGQGTFSYYAIANATRLLKREGRKDGMKVAVLMTDGIDHPKNPDVQSISEDARTAGILFITIGLSAVVNETKLRLISGDLPSVPILLLNDSTLVDKIQDRLDILFEKKCERKICECEKGDPGDPGPPGTHGNPGIKGERGPKGNPGDAQKGEPGERGPRGIPGYKGEKGERGECGKPGIKGDKGSPGPNGPKGPRGIQGIAGPPGDPGPKGFQGNKGEPGPPGPYGPPGAPGIGQQGVKGQRGQEGRTGPPGPTGVGEPGQTGPRGPEGPPGERGLPGEGLPGPKGEKGSQGAIGPQGEAGPSIKGDKGDMGPVGPQGLMGIPGIGSQGEQGIQGPIGPPGPQGPPGQGSPGPKGEVGQMGPTGPRGPVGLGVQGPKGEPGSIGLPGQPGVPGEDGAAGKKGEAGLPGARGPEGPPGKGQPGLKGDEGKKGSKGNQGQKGSQGPGGPKGDPGIMGPVGMPGISIPGPPGPKGDRGGPGMPGFKGEPGIAIRGPKGAQGPQGPVGAPGLKGDGYPGVPGPRGIPGPPGSRGLPGVGDTGAKGDPGVRGPPGPPGPRGIGTPGPKGDIGQKGLPGPPGSPGYGLQGIKGEHGERGDVGKKGDKGEIGDPGPQGEQGLQGPKGDQGLTKEEIIKLIFEICGCGRKCKETPLELLFVIDSSESVGLKNFQIIKNFVKTLTDRVALDLATTRVGIINYSHKVEEVAHLTQFSSKDDLKRAVDNMQYLGEGTYTATALHAANRMFEAAKPGVKKVALVITDGQTDTRDEKNLTEVVKNASDINVEIFVIGVVKRNDPNFHIFHQEMNLIATDPDSEHVYLFDDFITLEDTLKQKLFTKSCEDFEAYLFHILGSSPLQPGFGISGEERHESTPEPQKEISESVHVSRAQDRENEPSERTWAASPATTPSPEAATIPGPLPRPPEDQAKGLETRAPSSTSNLEPENFVHKDPRCLEPLQPGNCSEYVVRWYYDKQVNSCARFWFSGCKGSGNRFNSEKECEEICIQG", "length": 1124, "header": "tr|A0AAA9SPL9-1|E1BPV7_BOVIN Computationally mapped isoform of Collagen alpha-1(XXVIII) chain OS=Bos taurus OX=9913 GN=COL28A1 PE=3 SV=1 CANONICAL=E1BPV7-1" }, "locus": { "chromosome": "4", "start_pos": 15603392, "end_pos": 15425640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115260.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115260.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087303.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087303.1" } ] } }, { "isoform_ac": "A0AAA9TGS7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGS7/entry", "sequence": { "sequence": "MWNRRFVLYLLLLPAFMSQAIYGQRKKGSKTNLLARKNLQDSTCFIDLVFIVDSSESSKIFLFDKQKDFVGSLSDKIFQLTPVGSLKYDIKLAALQFSSSVQIDPPFSSWKDLQTFKQRVKSMNFIGQGTFSYYAIANATRLLKREGRKDGMKVAVLMTDGIDHPKNPDVQSISEDARTAGILFITIGLSAVVNETKLRLISGDLPSVPILLLNDSTLVDKIQDRLDILFEKKCERKICECEKGDPGDPGPPGTHGNPGIKGERGPKGNPGDAQKGEPGERGPRGIPGYKGEKGERGECGKPGIKGDKGSPGPNGPKGPRGIQGIAGPPGDPGPKGFQGNKGEPGPPGPYGPPGAPGIGQQGVKGQRGQEGRTGPPGPTGVGEPGQTGPRGPEGPPGERGLPGEGLPGPKGEKGSQGAIGPQGEAGPSIKGDKGDMGPVGPQGLMGIPGIGSQGEQGIQGPIGPPGPQGPPGQGSPGPKGEVGQMGPTGPRGPVGLGVQGPKGEPGSIGLPGQPGVPGEDGAAGKKGEAGLPGARGPEGPPGKGQPGLKGDEGKKGSKGNQGQKGSQGPGGPKGAQGPQGPVGAPGLKGDGYPGVPGPRGIPGPPGSRGLPGVGDTGAKGDPGVRGPPGPPGPRGIGTPGPKGDIGQKGLPGPPGSPGYGLQGIKGEQGPQGFPGPKGMTGHGLPGQKGEHGERGDVGKKGDKGEIGDPGPQGEQGLQGPKGDQGLTKEEIIKLIFEICGCGRKCKETPLELLFVIDSSESVGLKNFQIIKNFVKTLTDRVALDLATTRVGIINYSHKVEEVAHLTQFSSKDDLKRAVDNMQYLGEGTYTATALHAANRMFEAAKPGVKKVALVITDGQTDTRDEKNLTEVVKNASDINVEIFVIGVVKRNDPNFHIFHQEMNLIATDPDSEHVYLFDDFITLEDTLKQKLFTKSCEDFEAYLFHILGSSPLQPGFGISGEERHESTPEPQKEISESVHVSRAQDRENEPSERTWAASPATTPSPEAATIPGPLPRPPEDQAKGLETRAPSSTSNLEPENFVHKDPRCLEPLQPGNCSEYVVRWYYDKQVNSCARFWFSGCKGSGNRFNSEKECEEICIQG", "length": 1101, "header": "tr|A0AAA9TGS7-1|E1BPV7_BOVIN Computationally mapped isoform of Collagen alpha-1(XXVIII) chain OS=Bos taurus OX=9913 GN=COL28A1 PE=3 SV=1 CANONICAL=E1BPV7-1" }, "locus": { "chromosome": "4", "start_pos": 15603392, "end_pos": 15425640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109423.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109423.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097749.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097749.1" } ] } }, { "isoform_ac": "A0AAA9TJY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJY3/entry", "sequence": { "sequence": "MWNRRFVLYLLLLPAFMSQAIYGQRKKGSKTNLLARKNLQDSTCFIDLVFIVDSSESSKIFLFDKQKDFVGSLSDKIFQLTPVGSLKYDIKLAALQFSSSVQIDPPFSSWKDLQTFKQRVKSMNFIGQGTFSYYAIANATRLLKREGRKDGMKVAVLMTDGIDHPKNPDVQSISEDARTAGILFITIGLSAVVNETKLRLISGDLPSVPILLLNDSTLVDKIQDRLDILFEKKCERKICECEKGDPGDPGPPGTHGNPGIKGERGPKGNPGDAQKGEPGERGPRGIPGYKGEKGERGECGKPGIKGDKGSPGPNGPKGPRGIQGIAGPPGDPGPKGFQGNKGEPGPPGPYGPPGAPGIGQQGVKGQRGQEGRTGPPGPTGVGEPGQTGEKGSQGAIGPQGEAGPSIKGDKGDMGPVGPQGLMGIPGIGSQGEQGIQGPIGPPGPQGPPGQGSPGPKGEVGQMGPTGPRGPVGLGVQGPKGEPGSIGLPGQPGVPGEDGAAGKKGEAGLPGARGPEGPPGKGQPGLKGDEGKKGSKGNQGQKGSQGPGGPKGDPGIMGPVGMPGISIPGPPGPKGDRGGPGMPGFKGEPGIAIRGPKGAQGPQGPVGAPGLKGDGYPGVPGPRGIPGPPGSRGLPGVGDTGAKGDPGVRGPPGPPGPRGIGTPGPKGDIGQKGLPGPPGSPGYGLQGIKGEQGPQGFPGPKGMTGHGLPGQKGEHGERGDVGKKGDKGEIGDPGPQGEQGLQGPKGDQGLTKEEIIKLIFEICGCGRKCKETPLELLFVIDSSESVGLKNFQIIKNFVKTLTDRVALDLATTRVGIINYSHKVEEVAHLTQFSSKDDLKRAVDNMQYLGEGTYTATALHAANRMFEAAKPGVKKVALVITDGQTDTRDEKNLTEVVKNASDINVEIFVIGVVKRNDPNFHIFHQEMNLIATDPDSEHVYLFDDFITLEDTLKQKLFTKSCEDFEAYLFHILGSSPLQPGFGISGEERHESTPEPQKEISESVHVSRAQDRENEPSERTWAASPATTPSPEAATIPGPLPRPPEDQAKGLETRAPSSTSNLEPENFVHKDPRCLEPLQPGNCSEYVVRWYYDKQVNSCARFWFSGCKGSGNRFNSEKECEEICIQG", "length": 1124, "header": "tr|A0AAA9TJY3-1|E1BPV7_BOVIN Computationally mapped isoform of Collagen alpha-1(XXVIII) chain OS=Bos taurus OX=9913 GN=COL28A1 PE=3 SV=1 CANONICAL=E1BPV7-1" }, "locus": { "chromosome": "4", "start_pos": 15603392, "end_pos": 15425640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119270.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119270.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097484.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097484.1" } ] } }, { "isoform_ac": "E1BPV7-1", "url": "https://www.uniprot.org/uniprotkb/E1BPV7/entry", "sequence": { "sequence": "MWNRRFVLYLLLLPAFMSQAIYGQRKKGSKTNLLARKNLQDSTCFIDLVFIVDSSESSKIFLFDKQKDFVGSLSDKIFQLTPVGSLKYDIKLAALQFSSSVQIDPPFSSWKDLQTFKQRVKSMNFIGQGTFSYYAIANATRLLKREGRKDGMKVAVLMTDGIDHPKNPDVQSISEDARTAGILFITIGLSAVVNETKLRLISGDLPSVPILLLNDSTLVDKIQDRLDILFEKKCERKICECEKGDPGDPGPPGDAQKGEPGERGPRGIPGYKGEKGERGECGKPGIKGDKGSPGPNGPKGPRGIQGIAGPPGDPGPKGFQGNKGEPGPPGPYGPPGAPGIGQQGVKGQRGQEGRTGPPGPTGVGEPGQTGPRGPEGPPGERGLPGEGLPGPKGEKGSQGAIGPQGEAGPSIKGDKGDMGPVGPQGLMGIPGIGSQGEQGIQGPIGPPGPQGPPGQGSPGPKGEVGQMGPTGPRGPVGLGVQGPKGEPGSIGLPGQPGVPGEDGAAGKKGEAGLPGARGPEGPPGKGQPGLKGDEGKKGSKGNQGQKGSQGPGGPKGDPGIMGPVGMPGISIPGPPGPKGDRGGPGMPGFKGEPGIAIRGPKGAQGPQGPVGAPGLKGDGYPGVPGPRGIPGPPGSRGLPGVGDTGAKGDPGVRGPPGPPGPRGIGTPGPKGDIGQKGLPGPPGSPGYGLQGIKGEQGPQGFPGPKGMTGHGLPGQKGEHGERGDVGKKGDKGEIGDPGPQGEQGLQGPKGDQGLTKEEIIKLIFEICGCGRKCKETPLELLFVIDSSESVGLKNFQIIKNFVKTLTDRVALDLATTRVGIINYSHKVEEVAHLTQFSSKDDLKRAVDNMQYLGEGTYTATALHAANRMFEAAKPGVKKVALVITDGQTDTRDEKNLTEVVKNASDINVEIFVIGVVKRNDPNFHIFHQEMNLIATDPDSEHVYLFDDFITLEDTLKQKLFTKSCEDFEAYLFHILGSSPLQPGFGISGEERHESTPEPQKEISESVHVSRAQDRENEPSERTWAASPATTPSPEAATIPGPLPRPPEDQAKGLETRAPSSTSNLEPENFVHKDPRCLEPLQPGNCSEYVVRWYYDKQVNSCARFWFSGCKGSGNRFNSEKECEEICIQG", "length": 1129, "header": "tr|E1BPV7-1|E1BPV7_BOVIN Isoform 1 of Collagen alpha-1(XXVIII) chain OS=Bos taurus OX=9913 GN=COL28A1 PE=3 SV=4 CANONICAL=E1BPV7-1" }, "locus": { "chromosome": "4", "start_pos": 15603392, "end_pos": 15425640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000033859.5", "url": "https://www.ensembl.org/id/ENSBTAT00000033859.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000033767.5", "url": "https://www.ensembl.org/id/ENSBTAP00000033767.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1030, "start_aa": "Thr", "end_pos": 1030, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1030", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 361, "start_aa": "Thr", "end_pos": 361, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr361", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1650814", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "resource": "Reactome", "description": "Collagen biosynthesis and modifying enzymes" }, { "id": "R-BTA-8948216", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8948216", "resource": "Reactome", "description": "Collagen chain trimerization" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "E1BPV7", "url": "https://www.uniprot.org/uniprotkb/E1BPV7" } ], "pmid": "" }, { "name": "extracellular matrix structural constituent conferring tensile strength", "id": "GO:0030020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030020", "evidence": [ { "database": "UniProtKB", "id": "E1BPV7", "url": "https://www.uniprot.org/uniprotkb/E1BPV7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "E1BPV7", "url": "https://www.uniprot.org/uniprotkb/E1BPV7" } ], "pmid": "" }, { "name": "collagen fibril organization", "id": "GO:0030199", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030199", "evidence": [ { "database": "UniProtKB", "id": "E1BPV7", "url": "https://www.uniprot.org/uniprotkb/E1BPV7" } ], "pmid": "" }, { "name": "skeletal system morphogenesis", "id": "GO:0048705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048705", "evidence": [ { "database": "UniProtKB", "id": "E1BPV7", "url": "https://www.uniprot.org/uniprotkb/E1BPV7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "E1BPV7", "url": "https://www.uniprot.org/uniprotkb/E1BPV7" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "E1BPV7", "url": "https://www.uniprot.org/uniprotkb/E1BPV7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1084, "end_pos": 1086, "annotation": "n_glycosylation_sequon" }, { "start_pos": 138, "end_pos": 140, "annotation": "n_glycosylation_sequon" }, { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 822, "end_pos": 824, "annotation": "n_glycosylation_sequon" }, { "start_pos": 895, "end_pos": 897, "annotation": "n_glycosylation_sequon" }, { "start_pos": 902, "end_pos": 904, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPV7-F1", "pdb_chain": "global", 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"IPR045831", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045831", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534587", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534587", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KEEMIPP", "url": "https://omabrowser.org/oma/group/KEEMIPP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MIQ3", "url": "https://www.orthodb.org/?gene=F1MIQ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21689", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21689", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21689:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21689:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06584", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06584", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19438", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19438", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1538133", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1538133", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024832477", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832477", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKD4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKD4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKD4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RSE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSE5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIQ3", "url": "https://www.uniprot.org/uniprotkb/F1MIQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIQ3-1", "url": "https://www.uniprot.org/uniprotkb/F1MIQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTGSAVEMPFRNSKRSRLFSDEDDRQINTRSPKRNQRVAMVPQKFTATMSTPDKKASQKIGFRLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVADVSQFKDLPDEIPLPLVIGTKVTARLRGVHDGLFTGQIDAVDTLNATYRVTFDRAGLGTHTIPDYEVLSNEPHETMPIAAFGQKQRPSRFFMTPPRLHYTPPLQSPITDNDPLLGQSPWRSKISGSDTETLGGFPVEFLIQVTRLSKILMIKKEHIKKLREMNTEAEKLKSYSMPIGIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISRLTAILLQIKCLAEGGDLNSFEFKSLTDSLNDIKSTIDASNISCFQNNVEIHVAHIQSGLSQMGNLHAFAANNTNRD", "length": 558, "header": "tr|F1MIQ3-1|F1MIQ3_BOVIN Isoform 1 of Lin-9 DREAM MuvB core complex component OS=Bos taurus OX=9913 GN=LIN9 PE=3 SV=3 CANONICAL=F1MIQ3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKD4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKD4/entry", "sequence": { "sequence": "MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTGSAVEMPFRNSKRSRLFSDEDDRQINTRSPKRNQRVAMVPQKFTATMSTPDKKASQKIGFRLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVADVSQFKDLPDEIPLPLVIGTKVTARLRGVHDGLFTGQIDAVDTLNATYRVTFDRAGLGTHTIPDYEVLSNEPHETMPIAAFGQKQRPSRFFMTPPRLHYTPPLQSPITDNDPLLGQSPWRSKISGSDTETLGGFPVEFLIQVKSYSMPIGIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISRLTAILLQIKCLAEGGDLNSFEFKSLTDSLNDIKSTIDASNISCFQNNVEIHVAHIQSGLSQMGNLHAFAANNTNRD", "length": 531, "header": "tr|A0A3Q1LKD4-1|F1MIQ3_BOVIN Computationally mapped isoform of Lin-9 DREAM MuvB core complex component OS=Bos taurus OX=9913 GN=LIN9 PE=3 SV=2 CANONICAL=F1MIQ3-1" }, "locus": { "chromosome": "16", "start_pos": 29323608, "end_pos": 29239792, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069380.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069380.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057080.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057080.2" } ] } }, { "isoform_ac": "A0AAA9RSE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSE5/entry", "sequence": { "sequence": "MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTGSAVEMKFTATMSTPDKKASQKIGFRLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVADVSQFKDLPDEIPLPLVIGTKVTARLRGVHDGLFTGQIDAVDTLNATYRVTFDRAGLGTHTIPDYEVLSNEPHETMPIAAFGQKQRPSRFFMTPPRLHYTPPLQSPITDNDPLLGQSPWRSKISGSDTETLGGFPVEFLIQVTRLSKILMIKKEHIKKLREMNTEAEKLKSYSMPIGIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISRLTAILLQIKCLAEGGDLNSFEFKSLTDSLNDIKSTIDASNIR", "length": 489, "header": "tr|A0AAA9RSE5-1|F1MIQ3_BOVIN Computationally mapped isoform of Lin-9 DREAM MuvB core complex component OS=Bos taurus OX=9913 GN=LIN9 PE=3 SV=1 CANONICAL=F1MIQ3-1" }, "locus": { "chromosome": "16", "start_pos": 29323608, "end_pos": 29240379, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130203.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130203.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075470.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075470.1" } ] } }, { "isoform_ac": "F1MIQ3-1", "url": "https://www.uniprot.org/uniprotkb/F1MIQ3/entry", "sequence": { "sequence": "MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTGSAVEMPFRNSKRSRLFSDEDDRQINTRSPKRNQRVAMVPQKFTATMSTPDKKASQKIGFRLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVADVSQFKDLPDEIPLPLVIGTKVTARLRGVHDGLFTGQIDAVDTLNATYRVTFDRAGLGTHTIPDYEVLSNEPHETMPIAAFGQKQRPSRFFMTPPRLHYTPPLQSPITDNDPLLGQSPWRSKISGSDTETLGGFPVEFLIQVTRLSKILMIKKEHIKKLREMNTEAEKLKSYSMPIGIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISRLTAILLQIKCLAEGGDLNSFEFKSLTDSLNDIKSTIDASNISCFQNNVEIHVAHIQSGLSQMGNLHAFAANNTNRD", "length": 558, "header": "tr|F1MIQ3-1|F1MIQ3_BOVIN Isoform 1 of Lin-9 DREAM MuvB core complex component OS=Bos taurus OX=9913 GN=LIN9 PE=3 SV=3 CANONICAL=F1MIQ3-1" }, "locus": { "chromosome": "16", "start_pos": 29323608, "end_pos": 29239792, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047257.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047257.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044477.4", "url": "https://www.ensembl.org/id/ENSBTAP00000044477.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:534587", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534587", "resource": "KEGG Pathway" }, { "id": "R-BTA-1538133", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1538133", "resource": "Reactome", "description": "G0 and Early G1" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZRC0-1", "protein_name": "Lin-9 DREAM MuvB core complex component", "gene_name": "LIN9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAELDQLPDESSSAKALVSLKEGSLSNTWNEKYNSLQKTPVWKGRNTASAVEMPFRNSKRSRLFSDEDDRQINTRSPKRNQRVPQKFTAAVSTPDKKASQKIGFRLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVADVSQFKDLPDEIPLPLVIGTKVTARLRGVHDGLFTGQIDAVDTLNATYRVTFDRAGLGTHTVPDYEVLSNDSHETMPIAAFGQKQRPSRFFMTPPRLHYTPPLQSPITDNDPLLGQSPWRSKISGSDTETLGGFPVEFLIQVTRLSKILMIKKEHIKKLREMNTEAEKLKSYSMPIGIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRHANSSTGQPCVENDNLTDLISRLTAILLQIKCLAEGGDLNSFEFKSLTDSLNDIKSTIDASNISCFQNNVEIHVAHIQSGLSQMGNLHAFAANNTNRD", "length": 539 }, "evidence": [ { "id": "F1MIQ3", "url": "https://omabrowser.org/oma/group/F1MIQ3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "M0R885-1", "protein_name": "Lin-9 DREAM MuvB core complex component", "gene_name": "Lin9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNAGPAVEMPFRNSKRSRLFSDEDDRQINTKSPKRNQRVAMIPQKFTATMSTPDKKASQKIGFRLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVADVSQFKDLPDEIPLPLVIGTKVTARLRGIHDGLFTGQIDAVDTLNATYRVTFDRTGLGTHTIPDYEVLSNEPHETMPIAAFGQKQRPSRFFMTPPRLHYTPPLQSPITDGDPLLGQSPWRSKISGSDTETLGGFPVEFLIQVTKLSKILMIKKEHIKKLREMNTEAEKLKSYSMPIGIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRQANSASGQPCVENENLTDLISRLTAILLQIKCLAEGGDLNSFEFKSLTDSLNDIKNTIDASNISCFQNNVEIHVAHIQSGLSQMGNLHAFAANNTNRD", "length": 558 }, "evidence": [ { "id": "F1MIQ3", "url": "https://omabrowser.org/oma/group/F1MIQ3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5RHQ8-1", "protein_name": "Protein lin-9 homolog", "gene_name": "lin9", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAELEQLLDESSSAKALVSLREGSLSNTLNEKNNLPKSQTTRGRSSYVSMETPTRSSKRSRLSCEDEERPIASRSPRRSQRVTTMPQKLTNVATPDKRVSQKIGLRLRNLLKLPKAHKWCIYEWFYSNIDRPLFEGDNDFCLCLKESFPNLKTRKLTRVEWGTIRRLMGKPRRCSSAFFAEERMALKQKRQKMRLLQQRKITDMSLCKDLPDEIPLPLVIGTKVTARLRGVHDGLFTGQIDAVDTSAATYRVTFDRNGLGTHTVPDYEVLSNEPHETMPISAFAQKQRPPRFQNFLTPPRGSYTGSTQSILMDNDPLFSQSPWRSKLTGTDGETLGGFPVKFLVQVTRLSKILMIKKEHIKHLKEMNTEAEKLKSYSMPIGLDLQKRYATTVLDLEQLNKDLNKVLHEVQQFCFELAPDQGMQPADQPSELRRRCEEESQDVLRQNNTLASGEPRVQNTELTQLISRLTALLLQIRCLAEGGDLNSFEFKSLTDSLNDIKSSIDDSNLSCFQDNVEIHVAHIQSGLSQLGNLHAFSANNTNRT", "length": 543 }, "evidence": [ { "id": "F1MIQ3", "url": "https://omabrowser.org/oma/group/F1MIQ3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q5TKA1-1", "protein_name": "Protein lin-9 homolog", "gene_name": "LIN9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTSSAVEMPFRNSKRSRLFSDEDDRQINTRSPKRNQRVAMVPQKFTATMSTPDKKASQKIGFRLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVADVSQFKDLPDEIPLPLVIGTKVTARLRGVHDGLFTGQIDAVDTLNATYRVTFDRTGLGTHTIPDYEVLSNEPHETMPIAAFGQKQRPSRFFMTPPRLHYTPPLQSPIIDNDPLLGQSPWRSKISGSDTETLGGFPVEFLIQVTRLSKILMIKKEHIKKLREMNTEAEKLKSYSMPISIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRHANSSTGQPCVENENLTDLISRLTAILLQIKCLAEGGDLNSFEFKSLTDSLNDIKSTIDASNISCFQNNVEIHVAHIQSGLSQMGNLHAFAANNTNRD", "length": 542 }, "evidence": [ { "id": "F1MIQ3", "url": "https://omabrowser.org/oma/group/F1MIQ3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C735-1", "protein_name": "Protein lin-9 homolog", "gene_name": "Lin9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNAGPAVEMPFRNSKRSRLFSDEDDRQINTKSPKRNQRVAMIPQKFTATMSTPDKKASQKIGFRLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTRVEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVADVSQFKDLPDEIPLPLVIGTKVTARLRGIHDGLFTGQIDAVDTLNATYRVTFDRTGLGTHTIPDYEVLSNEPHETMPISAFGQKQRPSRFFMTPPRLHYTPPLQSPITDGDPLLGQSPWRSKVSGSDTETLGGFPVEFLIQVTKLSKILMIKKEHIKKLREMNTEAEKLKSYSMPIGIEFQRRYATIVLELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRQANSASGQPCVENENLTDLISRLTAILLQIKCLAEGGDLNSFEFKSLTDSLNDIKNTIDASNISCFQNNVEIHVAHIQSGLSQMGNLHAFAANNTNRD", "length": 542 }, "evidence": [ { "id": "F1MIQ3", "url": "https://omabrowser.org/oma/group/F1MIQ3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VZW3-1", "protein_name": "Always early, isoform A", "gene_name": "aly", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSVDPLSIDNFTIQSEICEENEFLANIGLLSTTTMSRHQLKKPRKMVAAWQNDELFIKRPNFAPRIRISEKPEIQGRIKPGVASKRTENFTKKPSNISVDVSEDEKAKEKEKEQDPYSNDFILGKRLYNFLKYLSSHRWIWCEFVDSFLDKPTLTMGYDMKRFIAEYCPLLHSCFMPRRGWQLVRRNMGKARRFSAAFIELEREELECQRRIVRQLQQHKFNPKENVGYLDQIPKRVPLPLAKDATVSSFLHGNSFEGIVNGTVMGYDPQDYTYLVRFNRNDNAVVLSLPDSQLYSDEETAAVPLSIIMRGNKSSSVISESAKTEKFGNKRYTKELLESVLRVGKLQDVKHKILMDLARMNEDFETFKEIGSSSSRRDAKVTPQRENLQRRYSASMITLHRVNADILEPLRILHDYLVEYQKQDEEEESKRGRPASEVYQKCRMQAEQDLKTAADEKFLKIESDRTQEFVRNLHTILYLNGKLGRENSSNLETIIADLVTHMVDNIQPSLGRKLKDGVDSLEPLRQQVVQIFKDVKKPERFQITQQAPMQTEDGIYNFVVEAQPDTPS", "length": 568 }, "evidence": [ { "id": "F1MIQ3", "url": "https://omabrowser.org/oma/group/F1MIQ3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MIQ3", "url": "https://www.uniprot.org/uniprotkb/F1MIQ3" } ], "pmid": "" }, { "name": "transcription repressor complex", "id": "GO:0017053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017053", "evidence": [ { "database": "UniProtKB", "id": "F1MIQ3", "url": "https://www.uniprot.org/uniprotkb/F1MIQ3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MIQ3", "url": "https://www.uniprot.org/uniprotkb/F1MIQ3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MIQ3", "url": "https://www.uniprot.org/uniprotkb/F1MIQ3" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MIQ3", "url": "https://www.uniprot.org/uniprotkb/F1MIQ3" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "F1MIQ3", "url": "https://www.uniprot.org/uniprotkb/F1MIQ3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MIQ3", "url": "https://www.uniprot.org/uniprotkb/F1MIQ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" }, { "start_pos": 463, "end_pos": 465, "annotation": "n_glycosylation_sequon" }, { "start_pos": 475, "end_pos": 477, "annotation": "n_glycosylation_sequon" }, { "start_pos": 522, "end_pos": 524, "annotation": "n_glycosylation_sequon" }, { "start_pos": 553, "end_pos": 555, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MIQ3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 558, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MIQ3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MIQ3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MIQ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIQ3" }, { "id": "SM01135", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01135" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DIRP", "eco_id": "ECO_0000259", "start_pos": 143, "end_pos": 248, "start_aa": "Phe", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 265, "end_pos": 267 }, { "start_pos": 463, "end_pos": 465 }, { "start_pos": 475, "end_pos": 477 }, { "start_pos": 522, "end_pos": 524 }, { "start_pos": 553, "end_pos": 555 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MG35-1", "uniprot_ac": "F1MG35", "uniprot_id": "F1MG35_BOVIN", "mass": { "chemical_mass": 131186.0, "monoisotopic_mass": 131186.0 }, "refseq": { "ac": "XP_010817557", "name": "MHC class II transactivator isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010817557" }, "gene_names": [ { "name": "CIITA", "type": "recommended", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "name": "CIITA", "type": "synonym", "evidence": [ { "id": "XP_010817557", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010817557" } ] } ], "protein_names": [ { "name": "Class II major histocompatibility complex transactivator", "type": "synonym", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35/entry#names_and_taxonomy" } ] }, { "name": "MHC class II transactivator isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010817557", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010817557" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MG35", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CIITA", "url": "https://www.uniprot.org/uniprotkb/F1MG35", "locus": { "chromosome": "25", "start_pos": 9600304, "end_pos": 9542266, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020649", "url": "https://www.ensembl.org/id/ENSBTAG00000020649" } ] } } ], "crossref": [ { "id": "F1MG35", "url": "https://alphafold.ebi.ac.uk/entry/F1MG35", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020649", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020649", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00116", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00116", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "508720", "url": "https://www.ncbi.nlm.nih.gov/gene/508720", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:508720", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508720", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PFAFPRH", "url": "https://omabrowser.org/oma/group/PFAFPRH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LQ73", "url": "https://www.orthodb.org/?gene=A0A3Q1LQ73", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MG35", "url": "https://www.orthodb.org/?gene=F1MG35", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47189", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47189", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47189:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47189:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05729", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05729", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010817557", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010817557", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LQ73", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ73", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQ73-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ73-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZW6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZW6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5S3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5S3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5S3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5S3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG35", "url": "https://www.uniprot.org/uniprotkb/F1MG35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG35-1", "url": "https://www.uniprot.org/uniprotkb/F1MG35-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNHFQTILSQVRMLLSSHRPSQVQALLDNLLAEELLSREYHHALLHESDGEALARKISLTLLEKGDPDFALLGWIWSGLQAPTAERGPSYKDPGGSGQCPTMELGPLEGSYLELLNSSADPLQLYHLYDRMDLTGEEEIELCSEPDTDTINCEQFSRLLCDMEGDEETREAYANIAELDQYVFQDTQLEGLSKDIFIEHIGLEEMISESVELLEEAGQKSQKRPFPEELPVDLKHRKLAEPLTMPVVTGTFLVGPVSDSLVQPCPPPPALFNTEPASSQTRLKDAAPPSSSLLSCLSLPAGPIQIIPTLPTLPQGLWPISGTGTGVSSILIYQSEMPPASQTPPSSGPAVQSLPKSPDRPGSASPFAPSAADLPSMPEPALTSRAGLTEDEMSPTKCPAAGGASSKLPKWPESVEQFYQSLRDKYQAQPTGPEGTLVDMDLVRVRLEKSSGKSQERELATLDWAERQPARGGLAEVLLAASDRQQPRETRVIAVLGKAGHGKSHWARAVSRAWAHGQLPQYDFVFCVPCHRLDRPGTSYRLQDLLSSLGPQPLPVDDEVLSYIARRPNRILLILDGFEDLEAHDGSLHSTGGPGSAEPRSLRGLLAGLLQRKLLRGCTLLLTAWPRGRLAQSLSKVDALFEVAGFSAQQVETYVRRYFESEGTAEHQERALALLQARPFLLSHSHSPTVCRTVCQLAEALLQRSDEAQLPSTLTGLYVGLLGPAARDSPPGALAELARLAWELGRVHQRGLKAGCLPSAEARAWAVAQGWLRPTPGAPETELAFSSFLLQCFLGAVWLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLVGLVFQPRAGCLGALAGPAATTSADRKQKVLTRYLKRLQPGTLQAGRLLELLHCAHEALDPGLWQHVLQGLPARLSFLGTRLTPPDTHVLGSALEAAGRDFSLDLRSTGVDASGLGSLVGLSCVTRFRAALSDTVELWESLQQRGEAKLLRAVEEKFTIEPFKAKSMKDVEDLGNLVQIQRTRSSSEAAAGELPAVRDLKKLEFALGPVLGPQVFPKLVKILEAFTSLQHLDLDSLSENKIGDEGVAQLSATFPQLKALETLNLSQNNITDVGACKLAEALPALATSLLRLSLYNNCICDAGAESLAHALPDMVSLRVLDVQYNKFTAAGAQQLAAGLRKCPQVKTLAMWTPTIPFGVQEHLQQLDPRIILR", "length": 1206, "header": "tr|F1MG35-1|F1MG35_BOVIN Isoform 1 of Class II major histocompatibility complex transactivator OS=Bos taurus OX=9913 GN=CIITA PE=4 SV=3 CANONICAL=F1MG35-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQ73-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQ73/entry", "sequence": { "sequence": "MRCLAPRPAGSYLPEPQGSGQCPTMELGPLEGSYLELLNSSADPLQLYHLYDRMDLTGEEEIELCSEPDTDTINCEQFSRLLCDMEGDEETREAYANIAELDQYVFQDTQLEGLSKDIFIEHIGLEEMISESVELLEEAGQKSQKRPFPEELPVDLKHRKLAEPLTMPVVTGTFLVGPVSDSLVQPCPPPPALFNTEPASSQTRLKDAAPPSSSLLSCLSLPAGPIQIIPTLPTLPQGLWPISGTGTGVSSILIYQSEMPPASQTPPSSGPAVQSLPKSPDRPGSASPFAPSAADLPSMPEPALTSRAGLTEDEMSPTKCPAAGGASSKLPKWPESVEQFYQSLRDKYQAQPTGPEGTLVDMDLVRVRLEKSSGKSQERELATLDWAERQPARGGLAEVLLAASDRQQPRETRVIAVLGKAGHGKSHWARAVSRAWAHGQLPQYDFVFCVPCHRLDRPGTSYRLQDLLSSLGPQPLPVDDEVLSYIARRPNRILLILDGFEDLEAHDGSLHSTGGPGSAEPRSLRGLLAGLLQRKLLRGCTLLLTAWPRGRLAQSLSKVDALFEVAGFSAQQVETYVRRYFESEGTAEHQERALALLQARPFLLSHSHSPTVCRTVCQLAEALLQRSDEAQLPSTLTGLYVGLLGPAARDSPPGALAELARLAWELGRVHQRGLKAGCLPSAEARAWAVAQGWLRPTPGAPETELAFSSFLLQCFLGAVWLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLVGLVFQPRAGCLGALAGPAATTSADRKQKVLTRYLKRLQPGTLQAGRLLELLHCAHEALDPGLWQHVLQGLPARLSFLGTRLTPPDTHVLGSALEAAGRDFSLDLRSTGVDASGLGSLVGLSCVTRFRAALSDTVELWESLQQRGEAKLLRAVEEKFTIEPFKAKSMKDVEDLGNLVQIQRTRSSSEAAAGELPAVRDLKKLEFALGPVLGPQVFPKLVKILEAFTSLQHLDLDSLSENKIGDEGVAQLSATFPQLKALETLNLSQNNITDVGACKLAEALPALATSLLRLSLYNNCICDAGAESLAHALPDMVSLRVLDVQYNKFTAAGAQQLAAGLRKCPQVKTLAMWTPTIPFGVQEHLQQLDPRIILR", "length": 1129, "header": "tr|A0A3Q1LQ73-1|F1MG35_BOVIN Computationally mapped isoform of Class II major histocompatibility complex transactivator OS=Bos taurus OX=9913 GN=CIITA PE=4 SV=2 CANONICAL=F1MG35-1" }, "locus": { "chromosome": "25", "start_pos": 9600270, "end_pos": 9554993, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075660.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075660.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059202.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059202.2" } ] } }, { "isoform_ac": "A0A3Q1LZW6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZW6/entry", "sequence": { "sequence": "MELGPLEGSYLELLNSSADPLQLYHLYDRMDLTGEEEIELCSEPDTDTINCEQFSRLLCDMEGDEETREAYANIAELDQYVFQDTQLEGLSKDIFIEHIGLEEMISESVELLEEAGQKSQKRPFPEELPVDLKHRKLAEPLTMPVVTGTFLVGPVSDSLVQPCPPPPALFNTEPASSQTRLKDAAPPSSSLLSCLSLPAGPIQIIPTLPTLPQGLWPISGTGTGVSSILIYQSEMPPASQTPPSSGPAVQSLPKSPDRPGSASPFAPSAADLPSMPEPALTSRAGLTEDEMSPTKCPAAGGASSKLPKWPESVEQFYQSLRDKYQAQPTGPEGTLVDMDLVRVRLEKSSGKSQERELATLDWAERQPARGGLAEVLLAASDRQQPRETRVIAVLGKAGHGKSHWARAVSRAWAHGQLPQYDFVFCVPCHRLDRPGTSYRLQDLLSSLGPQPLPVDDEVLSYIARRPNRILLILDGFEDLEAHDGSLHSTGGPGSAEPRSLRGLLAGLLQRKLLRGCTLLLTAWPRGRLAQSLSKVDALFEVAGFSAQQVETYVRRYFESEGTAEHQERALALLQARPFLLSHSHSPTVCRTVCQLAEALLQRSDEAQLPSTLTGLYVGLLGPAARDSPPGALAELARLAWELGRVHQRGLKAGCLPSAEARAWAVAQGWLRPTPGAPETELAFSSFLLQCFLGAVWLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLVGLVFQPRAGCLGALAGPAATTSADRKQKVLTRYLKRLQPGTLQAGRLLELLHCAHEALDPGLWQHVLQGLPARLSFLGTRLTPPDTHVLGSALEAAGRDFSLDLRSTGVDASGLGSLVGLSCVTRFRLGPVLGPQVFPKLVKILEAFTSLQHLDLDSLSENKIGDEGVAQLSATFPQLKALETLNLSQNNITDVGACKLAEALPALATSLLRLSLYNNCICDAGAESLAHALPDMVSLRVLDVQYNKFTAAGAQQLAAGLRKCPQVKTLAMWTPTIPFGVQEHLQQLDPRIILR", "length": 1028, "header": "tr|A0A3Q1LZW6-1|F1MG35_BOVIN Computationally mapped isoform of Class II major histocompatibility complex transactivator OS=Bos taurus OX=9913 GN=CIITA PE=4 SV=2 CANONICAL=F1MG35-1" }, "locus": { "chromosome": "25", "start_pos": 9600270, "end_pos": 9574983, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071246.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071246.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066442.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066442.2" } ] } }, { "isoform_ac": "A0A3Q1M5S3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5S3/entry", "sequence": { "sequence": "MRKSNPGKGSDLSKASGWMEQGCRTCGRREGRKLSGELAGGRSRRQRAQESRETMAGSGQCPTMELGPLEGSYLELLNSSADPLQLYHLYDRMDLTGEEEIELCSEPDTDTINCEQFSRLLCDMEGDEETREAYANIAELDQYVFQDTQLEGLSKDIFIEHIGLEEMISESVELLEEAGQKSQKRPFPEELPVDLKHRKLAEPLTMPVVTGTFLVGPVSDSLVQPCPPPPALFNTEPASSQTRLKDAAPPSSSLLSCLSLPAGPIQIIPTLPTLPQGLWPISGTGTGVSSILIYQSEMPPASQTPPSSGPAVQSLPKSPDRPGSASPFAPSAADLPSMPEPALTSRAGLTEDEMSPTKCPAAGGASSKLPKWPESVEQFYQSLRDKYQAQPTGPEGTLVDMDLVRVRLEKSSGKSQERELATLDWAERQPARGGLAEVLLAASDRQQPRETRVIAVLGKAGHGKSHWARAVSRAWAHGQLPQYDFVFCVPCHRLDRPGTSYRLQDLLSSLGPQPLPVDDEVLSYIARRPNRILLILDGFEDLEAHDGSLHSTGGPGSAEPRSLRGLLAGLLQRKLLRGCTLLLTAWPRGRLAQSLSKVDALFEVAGFSAQQVETYVRRYFESEGTAEHQERALALLQARPFLLSHSHSPTVCRTVCQLAEALLQRSDEAQLPSTLTGLYVGLLGPAARDSPPGALAELARLAWELGRVHQRGLKAGCLPSAEARAWAVAQGWLRPTPGAPETELAFSSFLLQCFLGAVWLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLVGLVFQPRAGCLGALAGPAATTSADRKQKVLTRYLKRLQPGTLQAGRLLELLHCAHEALDPGLWQHVLQGLPARLSFLGTRLTPPDTHVLGSALEAAGRDFSLDLRSTGVDASGLGSLVGLSCVTRFRAALSDTVELWESLQQRGEAKLLRAVEEKFTIEPFKAKSMKDVEDLGNLVQIQRTRSSSEAAAGELPAVRDLKKLEFALGPVLGPQVFPKLVKILEAFTSLQHLDLDSLSENKIGDEGVAQLSATFPQLKALETLNLSQNNITDVGACKLAEALPALATSLLRLSLYNNCICDAGAESLAHALPDMVSLRVLDVQYNKFTAAGAQQLAAGLRKCPQVKTLAMWTPTIPFGVQEHLQQLDPRIILR", "length": 1168, "header": "tr|A0A3Q1M5S3-1|F1MG35_BOVIN Computationally mapped isoform of Class II major histocompatibility complex transactivator OS=Bos taurus OX=9913 GN=CIITA PE=4 SV=2 CANONICAL=F1MG35-1" }, "locus": { "chromosome": "25", "start_pos": 9600270, "end_pos": 9556026, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079995.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079995.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069037.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069037.2" } ] } }, { "isoform_ac": "F1MG35-1", "url": "https://www.uniprot.org/uniprotkb/F1MG35/entry", "sequence": { "sequence": "MNHFQTILSQVRMLLSSHRPSQVQALLDNLLAEELLSREYHHALLHESDGEALARKISLTLLEKGDPDFALLGWIWSGLQAPTAERGPSYKDPGGSGQCPTMELGPLEGSYLELLNSSADPLQLYHLYDRMDLTGEEEIELCSEPDTDTINCEQFSRLLCDMEGDEETREAYANIAELDQYVFQDTQLEGLSKDIFIEHIGLEEMISESVELLEEAGQKSQKRPFPEELPVDLKHRKLAEPLTMPVVTGTFLVGPVSDSLVQPCPPPPALFNTEPASSQTRLKDAAPPSSSLLSCLSLPAGPIQIIPTLPTLPQGLWPISGTGTGVSSILIYQSEMPPASQTPPSSGPAVQSLPKSPDRPGSASPFAPSAADLPSMPEPALTSRAGLTEDEMSPTKCPAAGGASSKLPKWPESVEQFYQSLRDKYQAQPTGPEGTLVDMDLVRVRLEKSSGKSQERELATLDWAERQPARGGLAEVLLAASDRQQPRETRVIAVLGKAGHGKSHWARAVSRAWAHGQLPQYDFVFCVPCHRLDRPGTSYRLQDLLSSLGPQPLPVDDEVLSYIARRPNRILLILDGFEDLEAHDGSLHSTGGPGSAEPRSLRGLLAGLLQRKLLRGCTLLLTAWPRGRLAQSLSKVDALFEVAGFSAQQVETYVRRYFESEGTAEHQERALALLQARPFLLSHSHSPTVCRTVCQLAEALLQRSDEAQLPSTLTGLYVGLLGPAARDSPPGALAELARLAWELGRVHQRGLKAGCLPSAEARAWAVAQGWLRPTPGAPETELAFSSFLLQCFLGAVWLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLVGLVFQPRAGCLGALAGPAATTSADRKQKVLTRYLKRLQPGTLQAGRLLELLHCAHEALDPGLWQHVLQGLPARLSFLGTRLTPPDTHVLGSALEAAGRDFSLDLRSTGVDASGLGSLVGLSCVTRFRAALSDTVELWESLQQRGEAKLLRAVEEKFTIEPFKAKSMKDVEDLGNLVQIQRTRSSSEAAAGELPAVRDLKKLEFALGPVLGPQVFPKLVKILEAFTSLQHLDLDSLSENKIGDEGVAQLSATFPQLKALETLNLSQNNITDVGACKLAEALPALATSLLRLSLYNNCICDAGAESLAHALPDMVSLRVLDVQYNKFTAAGAQQLAAGLRKCPQVKTLAMWTPTIPFGVQEHLQQLDPRIILR", "length": 1206, "header": "tr|F1MG35-1|F1MG35_BOVIN Isoform 1 of Class II major histocompatibility complex transactivator OS=Bos taurus OX=9913 GN=CIITA PE=4 SV=3 CANONICAL=F1MG35-1" }, "locus": { "chromosome": "25", "start_pos": 9600270, "end_pos": 9542465, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027518.8", "url": "https://www.ensembl.org/id/ENSBTAT00000027518.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027518.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027518.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 774, "start_aa": "Thr", "end_pos": 774, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr774", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:508720", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508720", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M3AQW0-1", "protein_name": "MHC class II transactivator isoform X1", "gene_name": "ciita", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRLTRSCCPVMVPFEEVLFQVRKALQVDPSLVHDLLRELHEANVFSTQYYQSLYKDGEVAEESLCEVLCTDEDLDRKLSLLVWQNWDVSQDILHSTLNKQEDLVSTDGEANFIDPDPTLELPDSVLGEYLQSLLDGSIEETFDPTFFEDPNYSSLHTTDDKDTNCIPEKTSKVARPKKRKATTIDPQQIPCKQAIVVPESPSYELTPNITSGTEGSFHLSPYQPVFSFPISSPSLPSSALQFIQTISPLTSPLIGTVVQTGSTYVLVSPQSVSPGTQIIPLSPADGTVAPPELTGFVLPVGSSSGLTSVSVDTSPIKEGNPDKNTESPSPKLKNKVRPKAPECVKDYIHRLKSHLRDVCSTMRGGMGMQSHYVDAHLVQRKLLIKSGKNANKCLEKELVVLSDSERKKAKLDTSQLFHNLDSKSKQSFAFLGKSGVGKTTFIQRLCLDWSNSGLPQFQFVFLMNCKILDFKQSNYSLKTLLFDFSTSPHCEDSNAAFKHILSCPDEVLIIFDSFDHIKDLEGLLQSPAKSHTDTKYTIKQLFSGLFQKEILSGCTLLIATRPKDVLNQVLRKMDCLLEIWGFSPEDIELYTSKYFEEASLRESALQKIKNQGYMFSLCSNPLLCWATCFLLKHQDGEDLPSTLTDLYQRVTSKHLELASIGNSTKKKQLDTPQLCKMAWEGFKNHDTHVNLVKSTELLDCALKSGILIPYKTSEQEENHFADLFTQNFLSALHLVQSKQVNDKTVVANTMVQHKKRKVQGESQDVLQRFITGLIFQKTASGLSIIDSSVDLKAKRKAVEAHLESMKPKDLVPARLLELFHCVYETCSVKFAQGLVKNLPDDLSFCGTQLSPSDVYVICHILQHASAMKRTFTINLQDTCIPIRGLKELVGLKCIASFWAHAEDTIDLWEDLHQSNDELNLKSAIEKFTLNPLKATQGYHIESLPVLVQIHREKKLPTSELVPALDEGVPALRHLQKLEFGLGVQNGPELFPKVIEVLPSLQSLLCLDLDKNHIGDSGAEKLSGVLHFLECLKLLILSQNLIGDAGVGKLAQALASVPSLQTLRLYGNAIADSGAEHLALALPDMKSLQDLDVKFNKFTDIGATKLSAALKNCPGMKSLELWNNCIPYGVFEHLRLQDSRIKSL", "length": 1143 }, "evidence": [ { "id": "F1MG35", "url": "https://omabrowser.org/oma/group/F1MG35/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3V6C0-1", "protein_name": "MHC class II transactivator", "gene_name": "Ciita", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNHFQAILAQVQTLLSSQQPRQVRALLDGLLEEELLSREYHCALLHEPDGEALARKISLTLLEKGDLDLAFVSWVCNRLQVPEVERGPNCRDHGGHTLCATMELGSPEGSYLELLNSDADPLHLYHLYDQMDLAGEEEIELNSETDMDTINCDQFSKLLQDMEMDEETREAYANIAELDQYVFQDTQLEGLSKDLFIQHIGPEEGFGENVEGPAESGEKPQKRRFPEEHAMDSKHRKLGEMVPPSRTSLNYLDLPAGHIQIFTTLPQGLWQISGVGTGLSSVLVYHGEMPQVNQLLSSSSPTVPSLPESPDRPGSTSPFAPSTADLPGMPEPALTSRVNETEDTTPPSPCQEDPEPSIKLPKWPESVERFQHSLQDKYQALPGSPSGPLVAMELVRARLERGSNKSQERELATPDWTERQLAHGGLAEVLRVVGDSRRSRETQVVAVLGKAGQGKSHWARTVSHIWAQGQLPQYDFVFYVPCQCLDRPGDTYHLRDLLCPPNLQPLAMDDEVIDHIVRQPDRVLLILDAFEELEAQDSLLHGPCGPLSPEPCSLRGLLAGLFQRKLLRGCTLLLTARPRGRLAQSLSKADAIFEVPSFSTKQAQIYMRHYFENSGTAGSHDKALGLLEGQPFLLTHSHSPVLCSAVCQLSKALLDQGAEAQLPCTLTGLYVGLLGPAAQNSPPGALVELAKLAWELGRRHQSTLQETQFPSVEVKTWAVAQGLMQQTTEAQLAFSSFLLQCFLGAVWLAQCNEMKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLVFQPRAHCLGALVEPAMAAVADRKRKVLTRYLKRLKLGTLRAGRLLELLHCAHETQEPGIWKHVSHQLPGHLSFLGTRLTAPDVYVLGRALETASQDFSLDLRQTGIEPSRLGDLVGLSCVTSFRASLSDTMALWESLQHQGETQLLQAAEEKFTIEPFKAKSPKDVEDLDSLVQTQRLRNPSADAAKDLPAIRDLKKLEFALGPVLGPQAFPTLAKILPAFSSLQHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNSITDVGACKLAEALPALAKSLLRLSLYNNCICDEGAKSLARVLPDMVSLRVMDVQFNKFTAVGAQQLTSSLQKCPQVETLAMWTPTIPFGVQEHLQQLDARISLR", "length": 1156 }, "evidence": [ { "id": "F1MG35", "url": "https://omabrowser.org/oma/group/F1MG35/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P33076-1", "protein_name": "MHC class II transactivator", "gene_name": "CIITA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRCLAPRPAGSYLSEPQGSSQCATMELGPLEGGYLELLNSDADPLCLYHFYDQMDLAGEEEIELYSEPDTDTINCDQFSRLLCDMEGDEETREAYANIAELDQYVFQDSQLEGLSKDIFKHIGPDEVIGESMEMPAEVGQKSQKRPFPEELPADLKHWKPAEPPTVVTGSLLVGPVSDCSTLPCLPLPALFNQEPASGQMRLEKTDQIPMPFSSSSLSCLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSSIFIYHGEVPQASQVPPPSGFTVHGLPTSPDRPGSTSPFAPSATDLPSMPEPALTSRANMTEHKTSPTQCPAAGEVSNKLPKWPEPVEQFYRSLQDTYGAEPAGPDGILVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPSTLTGLYVGLLGRAALDSPPGALAELAKLAWELGRRHQSTLQEDQFPSADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSRISLR", "length": 1130 }, "evidence": [ { "id": "F1MG35", "url": "https://omabrowser.org/oma/group/F1MG35/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P79621-1", "protein_name": "MHC class II transactivator", "gene_name": "Ciita", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNHFQAILAQVQTLLSSQKPRQVRALLDGLLEEELLSREYHCALLHEPDGDALARKISLTLLEKGDLDLTFLSWVCNSLQAPTVERGTSYRDHGDHSLCATMDLGSPEGSYLELLNSDADPLHLYHLYDQMDLAGEEEIELSSEPDTDTINCDQFSKLLQDMELDEETREAYANIAELDQYVFQDTQLEGLSKDLFIEHIGAEEGFGENIEIPVEAGQKPQKRRFPEEHAMDSKHRKLVPTSRTSLNYLDLPTGHIQIFTTLPQGLWQISGAGTGLSSVLIYHGEMPQVNQVLPSSSLSIPSLPESPDRPGSTSPFTPSAADLPSMPEPALTSRVNETEDTSPSPCQEGPESSIKLPKWPEAVERFQHSLQDKYKALPQSPRGPLVAVELVRARLERGSNKSQERELATPDWTERQLAHGGLAEVLQVVSDCRRPGETQVVAVLGKAGQGKSHWARTVSHTWACGQLLQYDFVFYVPCHCLDRPGDTYHLRDLLCPPSLQPLAMDDEVLDYIVRQPDRVLLILDAFEELEAQDGLLHGPCGSLSPEPCSLRGLLAGIFQRKLLRGCTLLLTARPRGRLAQSLSKADAIFEVPSFSTKQAKTYMRHYFENSGTAGNQDKALGLLEGQPLLCSYSHSPVVCRAVCQLSKALLEQGTEAQLPCTLTGLYVSLLGPAAQNSPPGALVELAKLAWELGRRHQSTLQETRFSSVEVKTWAVTQGLMQQTLETTEAQLAFSSFLLQCFLGAVWLAQCNEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLVFQPRAHCLGALVEPAVAAVADRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQPGIWEHVAHQLPGHLSFLGTRLTPPDVYVLGRALETASQDFSLDLRQTGVEPSGLGNLVGLSCVTSFRASLSDTMALWESLQQQGEAQLLQAAEEKFTIEPFKAKSPKDVEDLDRLVQTQRLRNPSEDAAKDLPAIRDLKKLEFALGPILGPQAFPTLAKILPAFSSLQHLDLDSLSENKIGDKGVSKLSATFPQLKALETLNLSQNNITDVGACKLAEALPALAKSLLRLSLYNNCICDKGAKSLAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKCPQVETLAMWTPTIPFGVQEHLQQLDARISLR", "length": 1155 }, "evidence": [ { "id": "F1MG35", "url": "https://omabrowser.org/oma/group/F1MG35/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MG35", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "F1MG35", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1MG35", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ], "pmid": "" }, { "name": "acyltransferase activity", "id": "GO:0016746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016746", "evidence": [ { "database": "UniProtKB", "id": "F1MG35", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1MG35", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MG35", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1MG35", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "F1MG35", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ], "pmid": "" }, { "name": "response to type II interferon", "id": "GO:0034341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034341", "evidence": [ { "database": "UniProtKB", "id": "F1MG35", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ], "pmid": "" }, { "name": "positive regulation of MHC class I biosynthetic process", "id": "GO:0045345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045345", "evidence": [ { "database": "UniProtKB", "id": "F1MG35", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ], "pmid": "" }, { "name": "positive regulation of MHC class II biosynthetic process", "id": "GO:0045348", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045348", "evidence": [ { "database": "UniProtKB", "id": "F1MG35", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "PML body", "id": "GO:0016605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "database": "UniProtKB", "id": "F1MG35", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1097, "end_pos": 1099, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1102, "end_pos": 1104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", 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"id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { "uniprot_ac": "A0A3Q1MI36", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MI36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MI36" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": 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"uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": 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"MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAVSTLPAAPGGSVFPAGGGPLLTGGAAVHISAAGASKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVPHWLDHSKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGARLRRTSTFERKPSKRYPSRRHSTFKASNPVIAAQFCSKTNPEVHNYQPQYHPNLHPGQPRWHPHSPNVSYPLPSPGLSSSDRLPFGLEENGGTPFTAKASGRHHHHHHQHQHHTNYGLSLTLENKEGLSRSPNSSSKSLTKLSPGTPALFSEAAAHLKKLELETVKPAGPWPALHININKAEEKKVSEKTLQTPLLPSPVADHVKCNILKAQLENASRVSAQVGKEESTFVNINKKSTLQDANVRSPIPIRVETTQPAMEKPEIKPPRVRKLTRQYSFDEDDLPPDLAEAVGATTTPTTATTTATTTQVSMPLLSPKVHKISSPQNSEGKGQLSPGAKSPSNRRGAFTLEPGDLLMDFTEATPLAEPASAPHCAHSRCSPPLSLPMKEETTGVCMHPPIKTRLIKTFPADTVTPFPDPFITGPQFTADFRDSKVQCCPGQSSPLIPAATLRPLTEAVSTVQTIYTIRKPVSPATSAETLRQELEREKMMKRLLMTEL", "length": 896, "header": "tr|F1MD05-1|F1MD05_BOVIN Isoform 1 of Band 4.1-like protein 5 OS=Bos 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"MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAVSTLPAAPGGSVFPAGGGPLLTGGAAVHISAAGASKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVPHWLDHSKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGARLRRTSTFERKPSKRYPSRRHSTFKASNPVIAAQFCSKTNPEVHNYQPQYHPNLHPGQPRWHPHSPNVSYPLPSPGLSSSDRLPFGLEENGGTPFTAKASGRHHHHHHQHQHHTNYGLSLTLENKEGLSRSPNSSSKSLTKLSPGTPALFSEAAAHLKKLELETVKPAGPWPALHININKAEEKKVSEKTLQTPLLPSPVADHVKCNILKAQLENASRVSAQVGKEESTFVNINKKSTLQDANVRSPIPIRVETTQPAMEKPEIKPPRVRKLTRQYSFDEDDLPPDLAEAVGATTTPTTATTTATTTQVSMPLLSPKVHKISSPQNSEGKGQLSPGAKSPSNRRGAFTLEPGDLLMDFTEATPLIKTFPADTVTPFPDPFITGPQFTADFRDSKVQCCPGQSSPLIPAATLRPLTEAVSTVQTIYTIRKPVSPATSAETLRQELEREKMMKRLLMTEL", "length": 857, "header": "tr|A0AAA9TUD6-1|F1MD05_BOVIN Computationally mapped isoform of Band 4.1-like protein 5 OS=Bos taurus OX=9913 GN=EPB41L4B PE=4 SV=1 CANONICAL=F1MD05-1" }, "locus": { "chromosome": "8", "start_pos": 98868703, "end_pos": 98732993, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121772.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121772.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100720.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100720.1" } ] } }, { "isoform_ac": "F1MD05-1", "url": "https://www.uniprot.org/uniprotkb/F1MD05/entry", "sequence": { "sequence": "MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAVSTLPAAPGGSVFPAGGGPLLTGGAAVHISAAGASKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVPHWLDHSKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGARLRRTSTFERKPSKRYPSRRHSTFKASNPVIAAQFCSKTNPEVHNYQPQYHPNLHPGQPRWHPHSPNVSYPLPSPGLSSSDRLPFGLEENGGTPFTAKASGRHHHHHHQHQHHTNYGLSLTLENKEGLSRSPNSSSKSLTKLSPGTPALFSEAAAHLKKLELETVKPAGPWPALHININKAEEKKVSEKTLQTPLLPSPVADHVKCNILKAQLENASRVSAQVGKEESTFVNINKKSTLQDANVRSPIPIRVETTQPAMEKPEIKPPRVRKLTRQYSFDEDDLPPDLAEAVGATTTPTTATTTATTTQVSMPLLSPKVHKISSPQNSEGKGQLSPGAKSPSNRRGAFTLEPGDLLMDFTEATPLAEPASAPHCAHSRCSPPLSLPMKEETTGVCMHPPIKTRLIKTFPADTVTPFPDPFITGPQFTADFRDSKVQCCPGQSSPLIPAATLRPLTEAVSTVQTIYTIRKPVSPATSAETLRQELEREKMMKRLLMTEL", "length": 896, "header": "tr|F1MD05-1|F1MD05_BOVIN Isoform 1 of Band 4.1-like protein 5 OS=Bos taurus OX=9913 GN=EPB41L4B PE=4 SV=3 CANONICAL=F1MD05-1" }, "locus": { "chromosome": "8", "start_pos": 98868703, "end_pos": 98732993, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022699.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022699.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022699.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022699.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519310", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519310", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MD05", "url": "https://www.uniprot.org/uniprotkb/F1MD05" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MD05", "url": "https://www.uniprot.org/uniprotkb/F1MD05" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "F1MD05", "url": "https://www.uniprot.org/uniprotkb/F1MD05" } ], "pmid": "" }, { "name": "photoreceptor inner segment", "id": "GO:0001917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001917", "evidence": [ { "database": "UniProtKB", "id": "F1MD05", "url": "https://www.uniprot.org/uniprotkb/F1MD05" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "F1MD05", "url": "https://www.uniprot.org/uniprotkb/F1MD05" } ], "pmid": "" }, { "name": "apical part of cell", "id": "GO:0045177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "evidence": [ { "database": "UniProtKB", "id": "F1MD05", "url": "https://www.uniprot.org/uniprotkb/F1MD05" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cytoskeletal protein binding", "id": "GO:0008092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008092", "evidence": [ { "database": "UniProtKB", "id": "F1MD05", "url": "https://www.uniprot.org/uniprotkb/F1MD05" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "F1MD05", "url": "https://www.uniprot.org/uniprotkb/F1MD05" } ], "pmid": "" }, { "name": "positive regulation of cell adhesion", "id": "GO:0045785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045785", "evidence": [ { "database": "UniProtKB", "id": "F1MD05", "url": 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Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LVX9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVX9#function" }, { "database": "UniProtKB", "id": "ARBA00054898", "url": "https://www.uniprot.org/uniprotkb/ARBA00054898#function" }, { "database": "UniProtKB", "id": "F1MH50", "url": "https://www.uniprot.org/uniprotkb/F1MH50#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MH50", "url": "https://www.uniprot.org/uniprotkb/F1MH50" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLEKHH2", "url": "https://www.uniprot.org/uniprotkb/F1MH50", "locus": { "chromosome": "11", "start_pos": 25994746, "end_pos": 25888939, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032521", "url": "https://www.ensembl.org/id/ENSBTAG00000032521" } ] } } ], "crossref": [ { "id": "ENSBTAG00000032521", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032521", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13206", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13206", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13282", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13282", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd14473", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14473", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17179", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17179", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100299044", "url": "https://www.ncbi.nlm.nih.gov/gene/100299044", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019748", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019748", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035963", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035963", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100299044", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100299044", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NSMRLII", "url": "https://omabrowser.org/oma/group/NSMRLII/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MH50", "url": "https://www.orthodb.org/?gene=F1MH50", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22903", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22903", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22903:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22903:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00784", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00784", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21989", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21989", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691344", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691344", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVX9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVX9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVX9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH50", "url": "https://www.uniprot.org/uniprotkb/F1MH50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH50-1", "url": "https://www.uniprot.org/uniprotkb/F1MH50-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAELSETEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEEKLKAANIQTSESETRLYKKCQDLETLIQEKEDIIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIKTIQSKLQEVQGKKSVASTPKLSEGQRLSSLTFGCFLSRARSPPQVVKSEETSKISSKEPEFMEGKDIEEMEIPEKSVDNQIQENNRGQRTLHQGPCMSEQNRKTRTSFVMDGGTSQNSGAPGSDWSSDEEDGSKGRSKSRYTSTLSSHTSEEGVQSSRMGSETYLTASDDSSSIFEEETFGIKRLEHKKLYSWQQEAQWKAQNCPLGKGNSESRKKERDSSSDELNKKFQSQRLDYSSSSSEANTPSPILTPALSPKHPNPLLGKGTELGPSSTLPPPKLRIPNIFSLSIALAKRHLSQPQLSSDRMFGTNRNAISMIRPLRPQETDLDLVDGDNTEILETMDTNCDDGLFSYDCLESPCSEDQEACDSAKKAACGKPPTPPLHRFPSWESRIYAVAKSGIRMSEAFNMENVHKNSVAVLSYTTSGLYTSLIYKNMTTPVYTTLKGKATQISSSPFLDESSGSEEEDSSRSSSRTSESDSRSRSGPGSPRALKRGVSLSSVASESDYAIPPDAYSTDLEYSQPEQKLLKTCSSSSDNGKNEPLEKSGYLLKMSGKVKTWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLFLQPEGKPTVKGLLTKVKHGYSKRVWCKLIGKTLYYFRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKDQGPTYLLIGSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIEGEPSSQIWRHPTLCHSKEGIISPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEICCQLIKQTRWRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQQPGKWEGTRTVRLTYKNRLYFSMQVRGETDREKLLLMYQTNDQIVNGLFPLNRDLALEMAALLAQVEIGDFERPFSTPAGHVTNQCKANQTLKQAIEKFYPKRYRDDSSEEQLRQLCQRLSTRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFMWLAVHEDGLSILEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNAHSKDKPTEKLIFAMAKPKILEITLLIASYINNFYQQKAVHHLSAPALLSAQTQGCQARVMGSQPLLANSRPTKGPTLL", "length": 1491, "header": "tr|F1MH50-1|F1MH50_BOVIN Isoform 1 of Pleckstrin homology domain-containing family H member 2 OS=Bos taurus OX=9913 GN=PLEKHH2 PE=4 SV=3 CANONICAL=F1MH50-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVX9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVX9/entry", "sequence": { "sequence": "MAELSETEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEEKLKAANIQTSESETRLYKKCQDLETLIQEKEDIIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIKTIQSKLQEVQGKKSVASTPKLSEGQRLSSLTFGCFLSRARSPPQVVKSEETSKISSKEPEFMEGKDIEEMEIPEKSVDNQIQENNRGQRTLHQGPCMSEQNRKTRTSFVMDGGTSQNSGAPGSDWSSDEEDGSKGRSKSRYTSTLSSHTSEEGVQSSRMGSETYLTASDDSSSIFEEETFGIKRLEHKKLYSWQQEAQWKAQNCPLGKGNSESRKKERDSSSDELNKKFQSQRLDYSSSSSEANTPSPILTPALSPKHPNPLLGKGTELGPSSTLPPPKLRIPNIFSLSIALAKRHLSQPQLSSDRMFGTNRNAISMIRPLRPQETDLDLVDGDNTEILETMDTNCDDGLFSYDCLESPCSEDQEACDSAKKAACGKPPTPPLHRFPSWESRIYAVAKSGIRMSEAFNMENVHKNSVAVLSYTTSGLYTSLIYKNMTTPVYTTLKGKATQISSSPFLDESSGSEEEDSSRSSSRTSESDSRSRSGPGSPRALKRGVSLSSVASESDYAIPPDAYSTDLEYSQPEQKLLKTCSSSSDNGKNEPLEKSGYLLKMSGKVKTWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLFLQPEGKPTVKGLLTKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKDQGPTYLLIGSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIEGEPSSQIWRHPTLCHSKEGIISPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEICCQLIKQTRWRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQQPGKWEGTRTVRLTYKNRLYFSMQVRGETDREKLLLMYQTNDQIVNGLFPLNRDLALEMAALLAQVEIGDFERPFSTPAGHVTNQCKANQTLKQAIEKFYPKRYRDDSSEEQLRQLCQRLSTRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFMWLAVHEDGLSILEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNAHSKDKPTEKLIFAMAKPKILEITLLIASYINNFYQQKAVHHLSAPALLSAQTQGCQARVMGSQPLLANSRPTKGPTLL", "length": 1464, "header": "tr|A0A3Q1LVX9-1|F1MH50_BOVIN Computationally mapped isoform of Pleckstrin homology domain-containing family H member 2 OS=Bos taurus OX=9913 GN=PLEKHH2 PE=4 SV=2 CANONICAL=F1MH50-1" }, "locus": { "chromosome": "11", "start_pos": 25993742, "end_pos": 25897183, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073177.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073177.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061342.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061342.2" } ] } }, { "isoform_ac": "F1MH50-1", "url": "https://www.uniprot.org/uniprotkb/F1MH50/entry", "sequence": { "sequence": "MAELSETEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEEKLKAANIQTSESETRLYKKCQDLETLIQEKEDIIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIKTIQSKLQEVQGKKSVASTPKLSEGQRLSSLTFGCFLSRARSPPQVVKSEETSKISSKEPEFMEGKDIEEMEIPEKSVDNQIQENNRGQRTLHQGPCMSEQNRKTRTSFVMDGGTSQNSGAPGSDWSSDEEDGSKGRSKSRYTSTLSSHTSEEGVQSSRMGSETYLTASDDSSSIFEEETFGIKRLEHKKLYSWQQEAQWKAQNCPLGKGNSESRKKERDSSSDELNKKFQSQRLDYSSSSSEANTPSPILTPALSPKHPNPLLGKGTELGPSSTLPPPKLRIPNIFSLSIALAKRHLSQPQLSSDRMFGTNRNAISMIRPLRPQETDLDLVDGDNTEILETMDTNCDDGLFSYDCLESPCSEDQEACDSAKKAACGKPPTPPLHRFPSWESRIYAVAKSGIRMSEAFNMENVHKNSVAVLSYTTSGLYTSLIYKNMTTPVYTTLKGKATQISSSPFLDESSGSEEEDSSRSSSRTSESDSRSRSGPGSPRALKRGVSLSSVASESDYAIPPDAYSTDLEYSQPEQKLLKTCSSSSDNGKNEPLEKSGYLLKMSGKVKTWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLFLQPEGKPTVKGLLTKVKHGYSKRVWCKLIGKTLYYFRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKDQGPTYLLIGSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIEGEPSSQIWRHPTLCHSKEGIISPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEICCQLIKQTRWRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQQPGKWEGTRTVRLTYKNRLYFSMQVRGETDREKLLLMYQTNDQIVNGLFPLNRDLALEMAALLAQVEIGDFERPFSTPAGHVTNQCKANQTLKQAIEKFYPKRYRDDSSEEQLRQLCQRLSTRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFMWLAVHEDGLSILEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNAHSKDKPTEKLIFAMAKPKILEITLLIASYINNFYQQKAVHHLSAPALLSAQTQGCQARVMGSQPLLANSRPTKGPTLL", "length": 1491, "header": "tr|F1MH50-1|F1MH50_BOVIN Isoform 1 of Pleckstrin homology domain-containing family H member 2 OS=Bos taurus OX=9913 GN=PLEKHH2 PE=4 SV=3 CANONICAL=F1MH50-1" }, "locus": { "chromosome": "11", "start_pos": 25993742, "end_pos": 25897183, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046126.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046126.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043452.3", "url": "https://www.ensembl.org/id/ENSBTAP00000043452.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 540, "start_aa": "Thr", "end_pos": 540, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr540", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100299044", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100299044", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZNS6-1", "protein_name": "Pleckstrin homology domain-containing family H member 2", "gene_name": "Plekhh2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEESSEPERPIDWKERCVALEAQLMKFRVQASKIRELLADKMQQLERQVIDAERQAERAFQEVQVMEEKLKAANIQTSESETRLYKKCQDLESVMQEKDDLIQNLALRLEEQKQVRIKEAKTIEEKAAKIKEWVTVKLNELEVENQNLRFINQTQTEELRAIQSKLQELQEKKVSCVSSPKPSEGQRLSSLTFGCFLSRAKSPPCAVRSEEASKMASSEPEFAEARCVEEMEIAEKPADNQVQENSRSQRKLLETSCGSEHNRKTGASFVADGGTPEHSGLPVSDWSSDDDDGSKGRSKSRCTSTLSSHTSEEGGQCGRPGSEAYLTASDDSSSIFEEETFDANRPQHKKLYSWQQKAPWKAPSNLAKGSSQSEVKQRDSSSDELNKKFQSQRLDYSSSSSEANTPSPILTPALTPKHPNSLPGKGTPLVPPPFLPPPKLRIPNVFSISVALTKRHLSQPQLCSDRMFGMNRNAISMIRPLRPQETDLDMVDGDRAEAVDIMDTGCGDLFSYDSQDPPSAEDPENSEATKKASCSKPPTPPLHRFPSWESRIYAVAKSGIRVSEAFNMENANKNAASLLSHSVAGPYMSLIYKNVTTPVYTTLKGKATQISTSPFLDDSSGSDEEDGSRASSRSQSESETRSRSGPNSPRAMKRGVSDSSEGDYAIPPDAYSIDTECSQPEQKLLKTCSTSSDNGKSELLEKSGYLLKMSGRLKTWRRRWFVLKGGELLYYRSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVFQNVLRVQAANPLCLQPEGKPTVKGLLTKVKHGYSKRVWCTLVGKCLYYFRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYETSGRCLLSTHYTIIVHPKDQGPTYLLIGSKHEKEAWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIEGEPSSQIWRHPMLCHSKEGILCPLTSLPSEALQTEAIKLFKTCQLFINAVVDSPAIDYHISLAQSALQVCLTHPELQSEICCQLIKQTRRRQQQNQAGPLQGWQLLALCVGLFLPHHPFLWLLQVHLQRSADSRTEFGKYAIYCQRCVERTLQNGDREARPSRMEILSTLLRNPYHHSRPFSIPVHFMNGIYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKELQPGKCEGSRTVRLTYKNRLYFSMQARGETDREKLLLLYQTNEQIINGLFPLNKDLALEMAALLAQVDIGDFERPFSTPAGHVTNQCKANQTLKQVVEKFYPKRYREGCSEEQLRQLYQRLSTRWMALRGHSTTDCIRIYLTVARKWPFFGAKLFLAKPITPSSLGNNFIWLAVHENGLSILEYTSMRLVTGYVYKSVMTFGGYQEDFMVVISTQAKDRPTEKLLFAMAKPKILEITLLIASYINNFYQQKAAFHHLSAPALLSAKVQEPQAKAMGSQPLLSNNRPTKGPTLL", "length": 1488 }, "evidence": [ { "id": "F1MH50", "url": "https://omabrowser.org/oma/group/F1MH50/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8C115-1", "protein_name": "Pleckstrin homology domain-containing family H member 2", "gene_name": "Plekhh2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEPSEPEGLIDWKERCVALEAQLMKFRVQASKIRELLADKMQQLERQVIDAERQAEKAFQEVQVMEEKLKAANIQTSESETRLYKKCQDLESVMQEKDDIIQNLALRLEEQKQVRIQEAKIIEEKAAKIKEWVTVKLNELEVENQNLRFINQTQTEEIRAIQSKLQELQEKKISCVSSPKTSEGQRNLTFGCFLSRAKSPPCVVRCEEVSKMASNEPEITEGRCVEEMEIAEKPADNQVQENSRSQRKLHETSCSSEQNQKTRASFAMDGGTSQNSGVPVSDWSSDEDDGSKGRSKSRCTSTLSSHTSEEGGQCGRLGSEAYLTASDDSSSIFEEETFDGNRPEQKKLCSWQQKAPWKAQGNLAKGRSQSGVKEQDSSSDELNKKFHSQRLDYTSSSSEANTPSPILTPALTPRYPNSLPGKGGAPLVPPPFQPPPKLRVPNVFSISVALTKRHLSQPQLCSDRMFGTNRNAISMIRPLRPQETDLDVVDGDGAEAVNRMDTGCDDGLFSYDSQDPPPCADDQENSEAPKKAPCNKPPTPPLHRFPSWESRIYAVAKSGIRVSEAFNMEHANKNSADILSYSAASLYTSLIYKNMTTPVYTTLKGKATQISSSPFLDDSSGSDEEDSSRSSSRLSESDARSRSGPSSPRAMKRGVSDSSAASESDYAIPPDAYPIDAECSQPEQKLLKTCLASCDNGKNEPLEKSGYLLKMSVRVKTWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLATEKHTYYLTADSPNILEEWIKVLQSVLRVQAANPLCLQPEGKPAVKGLLTKVKHGYSKRVWCMLVGKVLYYFRNQEDKFPLGQLKLWEAKVEEVDRSCDSDEDYETRGCYLLSTHYTIIVHPKDQGPTYLLIGSKHEKEAWLYHLTVAAGSNNINVGSEFEQLVCKLLNIEGEPSSQIWRHPMLCHSKEGILSPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQVCLTHPELQNEICCQLIKQTRRRQLQNQPGPLQGWQLLALCVGLFLPHHPFLWLLQLHLQRNADSRTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSRPFSIPVHFMNGLYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQQPGKCEGSRTVRLTYKNRLYFSVQARGETDREKTLLLYQTNDQIINGLFPLNKDLALEMAALLAQVDIGDFERPFSTPAGPVTNQCKANQTLKQVIERFYPKRYREGCSEEQLRQLYQRLSTKWMALRGHSAADCIRIYLTVARKWPFFGAKLFFAKPIAPSSLGNNCVWLAVHENGLSILEYTSMRLVTSYMYKGLMTFGGYQEDFMVVVSTQSKDRPTEKLLFAMAKHKILEITLLIASYINSFHQQKTTFHHLSAPALLSPRTQAPQARVMGSQPPLSNSRPTKGPTLL", "length": 1491 }, "evidence": [ { "id": "F1MH50", "url": "https://omabrowser.org/oma/group/F1MH50/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IVE3-1", "protein_name": "Pleckstrin homology domain-containing family H member 2", "gene_name": "PLEKHH2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"categories": [ "Protein Classification" ] }, { "id": "F1MFS1", "url": "https://www.orthodb.org/?gene=F1MFS1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45656", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45656", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45656:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45656:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45656:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45656:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00084", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00084", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00431", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00431", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001411858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411858", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NHU3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NHU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NHU3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NHU3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFS1", "url": "https://www.uniprot.org/uniprotkb/F1MFS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFS1-1", "url": "https://www.uniprot.org/uniprotkb/F1MFS1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGIRKGESRAKESKPREPGTRKCAKCGRLDFILMKKMGIKSGFTFWNLVFLLTVSCVKGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHTTSTGELEEHNRTATGAIAVASTSADVTVSSVTAVTIHRLSEEQRVQVKNLRNSGLDPNTSKDGLSPHQADTQSTRRRPRNAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPDSPVLGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGPIPRCGAPCGGHFSAPSGLILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDPGYRLSHEEPLLCEKNHWWSHSLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSELPSTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGNRIGFTFGVGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDSEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENEMLLKEISGSLIPEGIHSTLNVVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNNMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYILQGYSTLTCIMGDDGRPGWNRVLPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSLVLFECNPGYILHGSIAIRCDTVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTIKLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVKVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNISMFVEFFQTEKEFDVLQVYDGPNIQSPVLVSLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYKLSSKELTTAICQSDGTWSNHNKTPRCVVVTCPSINSFTLEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDSGFMLVGSAVRECLSSGLWSGSDTRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPACVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPVCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRTLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESDFRTKSSVRFACDTGYILHGSEERTCLPNGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCVEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTTNGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNSPFILVGSSTRICQADGTWSGSSPHCIEPTRTSCDNPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLVYTCQPGFFLAGGTEHRVCRSDNTWTGKVPVCEAGSKILVKDPRPALGTPSPKLSVPDDVFAQNYIWKGSYNYKGKKQPMTLTVTSFNASTGRVNATLSNSNMELLLSGVYKSQEARLMLHIYLIKVPAQASVKKMKEENWAMDGFVSAEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNTKSVEGKAVRFDPNLNTVCTMV", "length": 3707, "header": "tr|F1MFS1-1|F1MFS1_BOVIN Isoform 1 of CUB and sushi domain-containing protein 3 OS=Bos taurus OX=9913 GN=CSMD3 PE=3 SV=4 CANONICAL=F1MFS1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWF2/entry", "sequence": { "sequence": "MKGIRKGESRAKESKPREPGTRKCAKCGRLDFILMKKMGIKSGFTFWNLVFLLTVSCVKGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPDSPVLGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGPIPRCGAPCGGHFSAPSGLILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDPGYRLSHEEPLLCEKNHWWSHSLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSELPSTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGNRIGFTFGVGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDSEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENEMLLKEISGSLIPEGIHSTLNVVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNNMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYILQGYSTLTCIMGDDGRPGWNRVLPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSLVLFECNPGYILHGSIAIRCDTVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTIKLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVKVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNISMFVEFFQTEKEFDVLQVYDGPNIQSPVLVSLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYKLSSKELTTAICQSDGTWSNHNKTPRCVVVTCPSINSFTLEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDSGFMLVGSAVRECLSSGLWSGSDTRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPACVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPVCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRTLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESDFRTKSSVRFACDTGYILHGSEERTCLPNGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCVEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTTNGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNSPFILVGSSTRICQADGTWSGSSPHCIEPTRTSCDNPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLVYTCQPGFFLAGGTEHRVCRSDNTWTGKVPVCEAGSKILVKDPRPALGTPSPKLSVPDDVFAQNYIWKGSYNYKGKKQPMTLTVTSFNASTGRVNATLSNSNMELLLSGVYKSQEARLMLHIYLIKVPAQASVKKMKEENWAMDGFVSAEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNTKSVEGKAVRFDPNLNTVCTMV", "length": 3603, "header": "tr|A0A3Q1LWF2-1|F1MFS1_BOVIN Computationally mapped isoform of CUB and sushi domain-containing protein 3 OS=Bos taurus OX=9913 GN=CSMD3 PE=3 SV=2 CANONICAL=F1MFS1-1" }, "locus": { "chromosome": "14", "start_pos": 52273950, "end_pos": 50805866, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083721.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083721.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061554.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061554.2" } ] } }, { "isoform_ac": "A0A3Q1NHU3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NHU3/entry", "sequence": { "sequence": "MKGIRKGESRAKESKPREPGTRKCAKCGRLDFILMKKMGIKSGFTFWNLVFLLTVSCVKGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPDSPVLGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGPIPRCGAPCGGHFSAPSGLILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDPGYRLSHEEPLLCEKNHWWSHSLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSELPSTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGNRIGFTFGVGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDSEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENEMLLKEISGSLIPEGIHSTLNVVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNNMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYILQGYSTLTCIMGDDGRPGWNRVLPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSLVLFECNPGYILHGSIAIRCDTVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTIKLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVKVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNISMFVEFFQTEKEFDVLQVYDGPNIQSPVLVSLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYKLSSKELTTAICQSDGTWSNHNKTPRCVVISCGELPTPPNGNKIGTQTSYGSTAIFTCDSGFMLVGSAVRECLSSGLWSGSDTRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPACVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPVCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRTLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESDFRTKSSVRFACDTGYILHGSEERTCLPNGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCVEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTTNGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNSPFILVGSSTRICQADGTWSGSSPHCIEPTRTSCDNPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLVYTCQPGFFLAGGTEHRVCRSDNTWTGKVPVCEAGSKILVKDPRPALGTPSPKLSVPDDVFAQNYIWKGSYNYKGKKQPMTLTVTSFNASTGRVNATLSNSNMELLLSGVYKSQEARLMLHIYLIKVPAQASVKKMKEENWAMDGFVSAEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNTKSVEGKAVRFDPNLNTVCTMV", "length": 3538, "header": "tr|A0A3Q1NHU3-1|F1MFS1_BOVIN Computationally mapped isoform of CUB and sushi domain-containing protein 3 OS=Bos taurus OX=9913 GN=CSMD3 PE=3 SV=2 CANONICAL=F1MFS1-1" }, "locus": { "chromosome": "14", "start_pos": 52273950, "end_pos": 50805866, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076307.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076307.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071545.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071545.2" } ] } }, { "isoform_ac": "F1MFS1-1", "url": "https://www.uniprot.org/uniprotkb/F1MFS1/entry", "sequence": { "sequence": "MKGIRKGESRAKESKPREPGTRKCAKCGRLDFILMKKMGIKSGFTFWNLVFLLTVSCVKGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHTTSTGELEEHNRTATGAIAVASTSADVTVSSVTAVTIHRLSEEQRVQVKNLRNSGLDPNTSKDGLSPHQADTQSTRRRPRNAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPDSPVLGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGPIPRCGAPCGGHFSAPSGLILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDPGYRLSHEEPLLCEKNHWWSHSLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSELPSTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGNRIGFTFGVGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDSEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENEMLLKEISGSLIPEGIHSTLNVVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNNMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYILQGYSTLTCIMGDDGRPGWNRVLPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSLVLFECNPGYILHGSIAIRCDTVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTIKLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVKVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNISMFVEFFQTEKEFDVLQVYDGPNIQSPVLVSLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYKLSSKELTTAICQSDGTWSNHNKTPRCVVVTCPSINSFTLEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDSGFMLVGSAVRECLSSGLWSGSDTRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPACVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPVCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRTLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESDFRTKSSVRFACDTGYILHGSEERTCLPNGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCVEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTTNGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNSPFILVGSSTRICQADGTWSGSSPHCIEPTRTSCDNPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLVYTCQPGFFLAGGTEHRVCRSDNTWTGKVPVCEAGSKILVKDPRPALGTPSPKLSVPDDVFAQNYIWKGSYNYKGKKQPMTLTVTSFNASTGRVNATLSNSNMELLLSGVYKSQEARLMLHIYLIKVPAQASVKKMKEENWAMDGFVSAEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNTKSVEGKAVRFDPNLNTVCTMV", "length": 3707, "header": "tr|F1MFS1-1|F1MFS1_BOVIN Isoform 1 of CUB and sushi domain-containing protein 3 OS=Bos taurus OX=9913 GN=CSMD3 PE=3 SV=4 CANONICAL=F1MFS1-1" }, "locus": { "chromosome": "14", "start_pos": 52273950, "end_pos": 50805866, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027766.8", "url": "https://www.ensembl.org/id/ENSBTAT00000027766.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027766.7", "url": "https://www.ensembl.org/id/ENSBTAP00000027766.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2764, "start_aa": "Thr", "end_pos": 2764, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2764", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3061, "start_aa": "Thr", "end_pos": 3061, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3061", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3235, "start_aa": "Thr", "end_pos": 3235, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3235", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3483, "start_aa": "Thr", "end_pos": 3483, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3483", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MFS1", "url": "https://www.uniprot.org/uniprotkb/F1MFS1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of dendrite development", "id": "GO:0050773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050773", "evidence": [ { "database": "UniProtKB", "id": "F1MFS1", "url": "https://www.uniprot.org/uniprotkb/F1MFS1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1092, "end_pos": 1094, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1126, "end_pos": 1128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1171, "end_pos": 1173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1280, "end_pos": 1282, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1536, "end_pos": 1538, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1591, "end_pos": 1593, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1709, "end_pos": 1711, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1781, "end_pos": 1783, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1929, "end_pos": 1931, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2019, "end_pos": 2021, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2155, "end_pos": 2157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2286, "end_pos": 2288, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2291, "end_pos": 2293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2324, "end_pos": 2326, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2495, "end_pos": 2497, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2537, "end_pos": 2539, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2684, "end_pos": 2686, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2711, "end_pos": 2713, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2742, "end_pos": 2744, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2862, "end_pos": 2864, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2932, "end_pos": 2934, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2952, "end_pos": 2954, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3099, "end_pos": 3101, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3158, "end_pos": 3160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3167, "end_pos": 3169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3194, "end_pos": 3196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3208, "end_pos": 3210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3218, "end_pos": 3220, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3276, "end_pos": 3278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3364, "end_pos": 3366, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3522, "end_pos": 3524, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3529, "end_pos": 3531, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3612, "end_pos": 3614, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3618, "end_pos": 3620, "annotation": "n_glycosylation_sequon" }, { "start_pos": 361, "end_pos": 363, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3627, "end_pos": 3629, "annotation": "n_glycosylation_sequon" }, { "start_pos": 409, "end_pos": 411, "annotation": "n_glycosylation_sequon" }, { "start_pos": 724, "end_pos": 726, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" }, { "start_pos": 823, "end_pos": 825, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" }, { "start_pos": 966, "end_pos": 968, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFS1" }, { "id": "PS01180", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01180" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CUB", "eco_id": "ECO_0000259", "start_pos": 65, "end_pos": 173, "start_aa": "Cys", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MFS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFS1" }, { "id": "PS50923", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50923" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sushi", "eco_id": "ECO_0000259", "start_pos": 176, "end_pos": 237, "start_aa": "Ser", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 2764, 3061, 3235, 3483 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1092, "end_pos": 1094 }, { "start_pos": 1126, "end_pos": 1128 }, { "start_pos": 1171, "end_pos": 1173 }, { "start_pos": 1280, "end_pos": 1282 }, { "start_pos": 1536, "end_pos": 1538 }, { "start_pos": 1591, "end_pos": 1593 }, { "start_pos": 1709, "end_pos": 1711 }, { "start_pos": 1781, "end_pos": 1783 }, { "start_pos": 1929, "end_pos": 1931 }, { "start_pos": 2019, "end_pos": 2021 }, { "start_pos": 2155, "end_pos": 2157 }, { "start_pos": 2286, "end_pos": 2288 }, { "start_pos": 2291, "end_pos": 2293 }, { "start_pos": 2324, "end_pos": 2326 }, { "start_pos": 2495, "end_pos": 2497 }, { "start_pos": 2537, "end_pos": 2539 }, { "start_pos": 2684, "end_pos": 2686 }, { "start_pos": 2711, "end_pos": 2713 }, { "start_pos": 2742, "end_pos": 2744 }, { "start_pos": 2862, "end_pos": 2864 }, { "start_pos": 2932, "end_pos": 2934 }, { "start_pos": 2952, "end_pos": 2954 }, { "start_pos": 3099, "end_pos": 3101 }, { "start_pos": 3158, "end_pos": 3160 }, { "start_pos": 3167, "end_pos": 3169 }, { "start_pos": 3194, "end_pos": 3196 }, { "start_pos": 3208, "end_pos": 3210 }, { "start_pos": 3218, "end_pos": 3220 }, { "start_pos": 3276, "end_pos": 3278 }, { "start_pos": 3364, "end_pos": 3366 }, { "start_pos": 3522, "end_pos": 3524 }, { "start_pos": 3529, "end_pos": 3531 }, { "start_pos": 3612, "end_pos": 3614 }, { "start_pos": 3618, "end_pos": 3620 }, { "start_pos": 361, "end_pos": 363 }, { "start_pos": 3627, "end_pos": 3629 }, { "start_pos": 409, "end_pos": 411 }, { "start_pos": 724, "end_pos": 726 }, { "start_pos": 73, "end_pos": 75 }, { "start_pos": 823, "end_pos": 825 }, { "start_pos": 90, "end_pos": 92 }, { "start_pos": 966, "end_pos": 968 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 4 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 4 }, { "field": "exact_o_linked_sites", "count": 4 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPP5-1", "uniprot_ac": "E1BPP5", "uniprot_id": "E1BPP5_BOVIN", "mass": { "chemical_mass": 79063.0, "monoisotopic_mass": 79063.0 }, "refseq": { "ac": "NP_001421780", "name": "interleukin-17 receptor C isoform 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421780" }, "gene_names": [ { "name": "IL17RC", "type": "recommended", "evidence": [ { "id": "E1BPP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP5" } ] }, { "name": "IL17RC", "type": "synonym", "evidence": [ { "id": "NP_001421780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421780" } ] } ], "protein_names": [ { "name": "Interleukin-17 receptor C", "type": "recommended", "evidence": [ { "id": "E1BPP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP5/entry#names_and_taxonomy" } ] }, { "name": "Interleukin-17 receptor-like protein", "type": "synonym", "evidence": [ { "id": "E1BPP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP5/entry#names_and_taxonomy" } ] }, { "name": "ZcytoR14", "type": "synonym", "evidence": [ { "id": "E1BPP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP5/entry#names_and_taxonomy" } ] }, { "name": "interleukin-17 receptor C isoform 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001421780", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421780" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPP5", "url": "https://www.uniprot.org/uniprotkb/E1BPP5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL17RC", "url": "https://www.uniprot.org/uniprotkb/E1BPP5", "locus": { "chromosome": "22", "start_pos": 16828786, "end_pos": 16840485, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033669", "url": "https://www.ensembl.org/id/ENSBTAG00000033669" } ] } } ], "crossref": [ { "id": "E1BPP5", "url": "https://alphafold.ebi.ac.uk/entry/E1BPP5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033669", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033669", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504855", "url": "https://www.ncbi.nlm.nih.gov/gene/504855", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXC2", "url": "https://www.orthodb.org/?gene=A0A3Q1LXC2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M600", "url": "https://www.orthodb.org/?gene=A0A3Q1M600", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N7H8", "url": "https://www.orthodb.org/?gene=A0A3Q1N7H8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NJD7", "url": "https://www.orthodb.org/?gene=A0A3Q1NJD7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NML8", "url": "https://www.orthodb.org/?gene=A0A3Q1NML8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BPP5", "url": "https://www.orthodb.org/?gene=E1BPP5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15583", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15583", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15583:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15583:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08357", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08357", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001421780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421780", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXC2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXC2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M600", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M600", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M600-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M600-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7H8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7H8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7H8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7H8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJD7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NJD7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJD7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NML8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NML8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NML8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NML8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF00", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SF00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF00-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLD8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLD8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPP5", "url": "https://www.uniprot.org/uniprotkb/E1BPP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPP5-1", "url": "https://www.uniprot.org/uniprotkb/E1BPP5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVPWFLLSLALGRNPVVLSLERVVGPQDTARCSPGLSCHLWDGDVLCLPGSLVSAPGPVLVPTRLQTELVLRCHEETDCDLCVRVAVHLAVQGYWEDPEDEEKFRRAADPELEEPRNASLQAHIVLSFQAYPTAHCVLLEVQVPAALVQPGQSVGSVVFDCFEAALGAEVQIWSYTQPRYQKELNLTQQLPDCRGLEVQDNIQSCWALPWLNVSADGEDVRLVLDVSEEQRFGLSLYWNQVQGPIKPWWHSNLTGPQTITLNHTDLVPCLCIQVWPLEPDSVRTSICPFREDPRAHRNLWRAARLQLLPPLEWRLDAPCSLPAEATLCWQPLDGGPCLSLVPPLPRENVTVNKVLEFPLLKGHPNVCVQVSTWEKLQLQECLWADSLGPRKDDMLLVETRGPQDNSSLCALEPSGCTPLLSRASTRAARLGEQLLQDVQSGQCLQLWDNDLGALWACPMDKYIHQRWALVWLACLLLAAVLFLLLLLKMSRVKGWLRLLKENIRAGAAARSRAALLLYSADDASFERLVGALASALCQLPLRVAVDLWSRRDLSAQGALAWFHAQRRQTLQEGGVVVLLFSPGAVALCREWLQDATSAPRAHDPHDAFAASLSCVLPDFLQGRAPGRYVGAYFDKLLPADAVPALFRSVPVFSLPSQLPDFLGTLQGSAAPRPRRLAERAEQVSRALQPALESCFRPPGAPGTGRGMGPEAGDRT", "length": 716, "header": "tr|E1BPP5-1|E1BPP5_BOVIN Isoform 1 of Interleukin-17 receptor C OS=Bos taurus OX=9913 GN=IL17RC PE=4 SV=3 CANONICAL=E1BPP5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXC2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXC2/entry", "sequence": { "sequence": "MPVPWFLLSLALGRNPVVLSLERVVGPQDTARCSPGLSCHLWDGDVLCLPGSLVSAPGPVLVPTRLQTELVLRCHEETDCDLCVRVAVHLAVQASLQAHIVLSFQAYPTAHCVLLEVQVPAALVQPGQSVGSVVFDCFEAALGAEVQIWSYTQPRYQKELNLTQQLPALPWLNVSADGEDVRLVLDVSEEQRFGLSLYWNQVQGPIKPWWHSNLTGPQTITLNHTDLVPCLCIQVWPLEPDSVRTSICPFREDPRAHRNLWRAARLQLLPPLEWRLDAPCSLPAEATLCWQPLDGGPCLSLVPPLPRENVTVNKVLEFPLLKGHPNVCVQQVSTWEKLQLQECLWADSLGPRKDDMLLVETRGPQDNSSLCALEPSGCTPLLSRASTRAARLGEQLLQDVQSGQCLQLWDNDLGALWACPMDKYIHQRWALVWLACLLLAAVLFLLLLLKMSRVKAAARSRAALLLYSADDASFERLVGALASALCQLPLRVAVDLWSRRDLSAQGALAWFHAQRRQTLQEGGVVVLLFSPGAVALCREWLQDATSAPRAHDPHDAFAASLSCVLPDFLQGRAPGRYVGAYFDKLLPADAVPALFRSVPVFSLPSQLPDFLGTLQGSAAPRPRRLAERAEQVSRALQPALESCFRPPGAPGTGRGMGPEAGDRT", "length": 664, "header": "tr|A0A3Q1LXC2-1|E1BPP5_BOVIN Computationally mapped isoform of Interleukin-17 receptor C OS=Bos taurus OX=9913 GN=IL17RC PE=4 SV=2 CANONICAL=E1BPP5-1" }, "locus": { "chromosome": "22", "start_pos": 16840283, "end_pos": 16828960, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072246.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072246.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061848.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061848.2" } ] } }, { "isoform_ac": "A0A3Q1M600-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M600/entry", "sequence": { "sequence": "MPVPWFLLSLALGRNPVVLSLERVVGPQDTARCSPGLSCHLWDGDVLCLPGSLVSAPGPVLVPTRLQTELVLRCHEETDCDLCVRVAVHLAVQGYWEDPEDEEKFRRAADPELEEPRNASLQAHIVLSFQAYPTAHCVLLEVQVPAALVQPGQSVGSVVFDCFEAALGAEVQIWSYTQPRYQKELNLTQQLPDCRGLEVQDNIQSCWALPWLNVSADGEDVRLVLDVSEEQRFGLSLYWNQVQGPIKPWWHSNLVWPLEPDSVRTSICPFREDPRAHRNLWRAARLQLLPPLEWRLDAPCSLPAEATLCWQPLDGGPCLSLVPPLPRENVTVNKVLEFPLLKGHPNVCVQVSTWEKLQLQECLWADSLGPRKDDMLLVETRGPQDNSSLCALEPSGCTPLLSRASTRAARLGEQLLQDVQSGQCLQLWDNDLGALWACPMDKYIHQRWALVWLACLLLAAVLFLLLLLKMSRVKAAARSRAALLLYSADDASFERLVGALASALCQLPLRVAVDLWSRRDLSAQGALAWFHAQRRQTLQEGGVVVLLFSPGAVALCREWLQDATSAPRAHDPHDAFAASLSCVLPDFLQGRAPGRYVGAYFDKLLPADAVPALFRSVPVFSLPSQLPDFLGTLQGSAAPRPRRLAERAEQVSRALQPALESCFRPPGAPGTGRGMGPEAGDRT", "length": 683, "header": "tr|A0A3Q1M600-1|E1BPP5_BOVIN Computationally mapped isoform of Interleukin-17 receptor C OS=Bos taurus OX=9913 GN=IL17RC PE=4 SV=2 CANONICAL=E1BPP5-1" }, "locus": { "chromosome": "22", "start_pos": 16840283, "end_pos": 16828960, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067604.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067604.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063711.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063711.2" } ] } }, { "isoform_ac": "A0A3Q1N7H8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7H8/entry", "sequence": { "sequence": "MPVPWFLLSLALGRNPVVLSLERVVGPQDTARCSPGLSCHLWDGDVLCLPGSLVSAPGPVLVPTRLQTELVLRCHEETDCDLCVRVAVHLAVQGYWEDPEDEEKFRRAADPELEEPRNASLQAHIVLSFQAYPTAHCVLLEVQVPAALVQPGQSVGSVVFDCFEAALGAEVQIWSYTQPRYQKELNLTQQLPALPWLNVSADGEDVRLVLDVSEEQRFGLSLYWNQVQGPIKPWWHSNLTGPQTITLNHTDLVPCLCIQVWPLEPDSVRTSICPFREDPRAHRNLWRAARLQLLPPLEWRLDAPCSLPAEATLCWQPLDGGPCLSLVPPLPRENVTVNKVLEFPLLKGHPNVCVQVSTWEKLQLQECLWADSLGPRKDDMLLVETRGPQDNSSLCALEPSGCTPLLSRASTRAARLGEQLLQDVQSGQCLQLWDNDLGALWACPMDKYIHQRWALVWLACLLLAAVLFLLLLLKMSRVKGWLRLLKENIRAGAAARSRAALLLYSADDASFERLVGALASALCQLPLRVAVDLWSRRDLSAQGALAWFHAQRRQTLQEGGVVVLLFSPGAVALCREWLQDATSAPRAHDPHDAFAASLSCVLPDFLQGRAPGRYVGAYFDKLLPADAVPALFRSVPVFSLPSQLPDFLGTLQGSAAPRPRRLAERAEQVSRALQPALESCFRPPGAPGTGRGMGPEAGDRT", "length": 701, "header": "tr|A0A3Q1N7H8-1|E1BPP5_BOVIN Computationally mapped isoform of Interleukin-17 receptor C OS=Bos taurus OX=9913 GN=IL17RC PE=4 SV=2 CANONICAL=E1BPP5-1" }, "locus": { "chromosome": "22", "start_pos": 16840283, "end_pos": 16828960, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071084.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071084.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066663.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066663.2" } ] } }, { "isoform_ac": "A0A3Q1NJD7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NJD7/entry", "sequence": { "sequence": "MPVPWFLLSLALGRNPVVLSLERVVGPQDTARCSPGLSCHLWDGDVLCLPGSLVSAPGPVLVPTRLQTELVLRCHEETDCDLCVRVAVHLAVQGYWEDPEDEEKFRRAADPELEEPRNASLQAHIVLSFQAYPTAHCVLLEVQVPAALVQPGQSVGSVVFDCFEAALGAEVQIWSYTQPRYQKELNLTQQLPDCRGLEVQDNIQSCWALPWLNVSADGEDVRLVLDVSEEQRFGLSLYWNQVQGPIKPWWHSNLTGPQTITLNHTDLVPCLCIQVWPLEPDSVRTSICPFREDPRAHRNLWRAARLQLLPPLEWRLDAPCSLPAEATLCWQPLDGGPCLSLVPPLPRENVTVNVSTWEKLQLQECLWADSLGPRKDDMLLVETRGPQDNSSLCALEPSGCTPLLSRASTRAARLGEQLLQDVQSGQCLQLWDNDLGALWACPMDKYIHQRWALVWLACLLLAAVLFLLLLLKMSRVKAAARSRAALLLYSADDASFERLVGALASALCQLPLRVAVDLWSRRDLSAQGALAWFHAQRRQTLQEGGVVVLLFSPGAVALCREWLQDATSAPRAHDPHDAFAASLSCVLPDFLQGRAPGRYVGAYFDKLLPADAVPALFRSVPVFSLPSQLPDFLGTLQGSAAPRPRRLAERAEQVSRALQPALESCFRPPGAPGTGRGMGPEAGDRT", "length": 686, "header": "tr|A0A3Q1NJD7-1|E1BPP5_BOVIN Computationally mapped isoform of Interleukin-17 receptor C OS=Bos taurus OX=9913 GN=IL17RC PE=4 SV=2 CANONICAL=E1BPP5-1" }, "locus": { "chromosome": "22", "start_pos": 16840283, "end_pos": 16828960, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075684.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075684.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072261.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072261.2" } ] } }, { "isoform_ac": "A0A3Q1NML8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NML8/entry", "sequence": { "sequence": "MPVPWFLLSLALGRNPVVLSLERVVGPQDTARCSPGLSCHLWDGDVLCLPGSLVSAPGPVLVPTRLQTELVLRCHEETDCDLCVRVAVHLAVQGYWEDPEDEEKFRRAADPELEEPRNASLQAHIVLSFQAYPTAHCVLLEVQVPAALVQPGQSVGSVVFDCFEAALGAEVQIWSYTQPRYQKELNLTQQLPDCRGLEVQDNIQSCWALPWLNVSADGEDVRLVLDVSEEQRFGLSLYWNQVQGPIKPWWHSNLTGPQTITLNHTDLVPCLCIQVWPLEPDSVRTSICPFREDPRAHRNLWRAARLQLLPPLEWRLDAPCSLPAEATLCWQPLDGGPCLSLVPPLPRENVTVNKVLEFPLLKGHPNVCVQVSTWEKLQLQECLWADSLGPRKDDMLLVETRGPQDNSSLCALEPSGCTPLLSRASTRAARLGEQLLQDVQSGQCLQLWDNDLGALWACPMDKYIHQRWALVWLACLLLAAVLFLLLLLKMSRVKAAARSRAALLLYSADDASFERLVGALASALCQLPLRVAVDLWSRRDLSAQGALAWFHAQRRQTLQEGGVVVLLFSPGAVALCREWLQDATSAPRAHDPHDAFAASLSCVLPDFLQGRAPGRYVGAYFDKLLPADAVPALFRSVPVFSLPSQLPDFLGTLQGSAAPRPRRLAERAEQVSRALQPALESCFRPPGAPGTGRGMGPEAGDRT", "length": 703, "header": "tr|A0A3Q1NML8-1|E1BPP5_BOVIN Computationally mapped isoform of Interleukin-17 receptor C OS=Bos taurus OX=9913 GN=IL17RC PE=4 SV=2 CANONICAL=E1BPP5-1" }, "locus": { "chromosome": "22", "start_pos": 16840283, "end_pos": 16828960, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074184.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074184.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073862.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073862.2" } ] } }, { "isoform_ac": "A0AAA9SF00-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SF00/entry", "sequence": { "sequence": "MPVPWFLLSLALGRNPVVLSLERVVGPQDTARCSPGLSCHLWDGDVLCLPGSLVSAPGPVLVPTRLQTELVLRCHEETDCDLCVRVAVHLAVQASLQAHIVLSFQAYPTAHCVLLEVQVPAALVQPGQSVGSVVFDCFEAALGAEVQIWSYTQPRYQKELNLTQQLPALPWLNVSADGEDVRLVLDVSEEQRFGLSLYWNQVQGPIKPWWHSNLTGPQTITLNHTDLVPCLCIQVWPLEPDSVRTSICPFREDPRAHRNLWRAARLQLLPPLEWRLDAPCSLPAEATLCWQPLDGGPCLSLVPPLPRENVTVNKVLEFPLLKGHPNVCVQQVSTWEKLQLQECLWADSLGPRKDDMLLVETRGPQDNSSLCALEPSGCTPLLSRASTLWDNDLGALWACPMDKYIHQRWALVWLACLLLAAVLFLLLLLKMSRVKAAARSRAALLLYSADDASFERLVGALASALCQLPLRVAVDLWSRRDLSAQGALAWFHAQRRQTLQEGGVVVLLFSPGAVALCREWLQDATSAPRAHDPHDAFAASLSCVLPDFLQGRAPGRYVGAYFDKLLPADAVPALFRSVPVFSLPSQLPDFLGTLQGSAAPRPRRLAERAEQVSRALQPALESCFRPPGAPGTGRGMGPEAGDRT", "length": 644, "header": "tr|A0AAA9SF00-1|E1BPP5_BOVIN Computationally mapped isoform of Interleukin-17 receptor C OS=Bos taurus OX=9913 GN=IL17RC PE=4 SV=1 CANONICAL=E1BPP5-1" }, "locus": { "chromosome": "22", "start_pos": 16840283, "end_pos": 16828960, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123795.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123795.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084736.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084736.1" } ] } }, { "isoform_ac": "A0AAA9SLD8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLD8/entry", "sequence": { "sequence": "MPVPWFLLSLALGRNPVVLSLERVVGPQDTARCSPHLPHPSHADGDVLCLPGSLVSAPGPVLVPTRLQTELVLRCHEETDCDLCVRVAVHLAVQGYWEDPEDEEKFRRAADPELEEPRNASLQAHIVLSFQAYPTAHCVLLEVQVPAALVQPGQSVGSVVFDCFEAALGAEVQIWSYTQPRYQKELNLTQQLPDCRGLEVQDNIQSCWALPWLNVSADGEDVRLVLDVSEEQRFGLSLYWNQVQGPIKPWWHSNLTGPQTITLNHTDLVPCLCIQVWPLEPDSVRTSICPFREDPRAHRNLWRAARLQLLPPLEWRLDAPCSLPAEATLCWQPLDGGPCLSLVPPLPRENVTVNKVLEFPLLKGHPNVCVQARRGRQRAELGKGPARTPSLLDPLYPWVPGAKWLPTSSLGVPLFTLAVHGMRAWALHLSECQSPHVFNGDDNSNYFTDED", "length": 451, "header": "tr|A0AAA9SLD8-1|E1BPP5_BOVIN Computationally mapped isoform of Interleukin-17 receptor C OS=Bos taurus OX=9913 GN=IL17RC PE=4 SV=1 CANONICAL=E1BPP5-1" }, "locus": { "chromosome": "22", "start_pos": 16840283, "end_pos": 16833547, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100074.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100074.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086069.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086069.1" } ] } }, { "isoform_ac": "E1BPP5-1", "url": "https://www.uniprot.org/uniprotkb/E1BPP5/entry", "sequence": { "sequence": "MPVPWFLLSLALGRNPVVLSLERVVGPQDTARCSPGLSCHLWDGDVLCLPGSLVSAPGPVLVPTRLQTELVLRCHEETDCDLCVRVAVHLAVQGYWEDPEDEEKFRRAADPELEEPRNASLQAHIVLSFQAYPTAHCVLLEVQVPAALVQPGQSVGSVVFDCFEAALGAEVQIWSYTQPRYQKELNLTQQLPDCRGLEVQDNIQSCWALPWLNVSADGEDVRLVLDVSEEQRFGLSLYWNQVQGPIKPWWHSNLTGPQTITLNHTDLVPCLCIQVWPLEPDSVRTSICPFREDPRAHRNLWRAARLQLLPPLEWRLDAPCSLPAEATLCWQPLDGGPCLSLVPPLPRENVTVNKVLEFPLLKGHPNVCVQVSTWEKLQLQECLWADSLGPRKDDMLLVETRGPQDNSSLCALEPSGCTPLLSRASTRAARLGEQLLQDVQSGQCLQLWDNDLGALWACPMDKYIHQRWALVWLACLLLAAVLFLLLLLKMSRVKGWLRLLKENIRAGAAARSRAALLLYSADDASFERLVGALASALCQLPLRVAVDLWSRRDLSAQGALAWFHAQRRQTLQEGGVVVLLFSPGAVALCREWLQDATSAPRAHDPHDAFAASLSCVLPDFLQGRAPGRYVGAYFDKLLPADAVPALFRSVPVFSLPSQLPDFLGTLQGSAAPRPRRLAERAEQVSRALQPALESCFRPPGAPGTGRGMGPEAGDRT", "length": 716, "header": "tr|E1BPP5-1|E1BPP5_BOVIN Isoform 1 of Interleukin-17 receptor C OS=Bos taurus OX=9913 GN=IL17RC PE=4 SV=3 CANONICAL=E1BPP5-1" }, "locus": { "chromosome": "22", "start_pos": 16840283, "end_pos": 16828960, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061562.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061562.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053394.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053394.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BPP5", "url": "https://www.uniprot.org/uniprotkb/E1BPP5" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "E1BPP5", "url": "https://www.uniprot.org/uniprotkb/E1BPP5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "E1BPP5", "url": "https://www.uniprot.org/uniprotkb/E1BPP5" } ], "pmid": "" }, { "name": "positive regulation of interleukin-6 production", "id": "GO:0032755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", "evidence": [ { "database": "UniProtKB", "id": "E1BPP5", "url": "https://www.uniprot.org/uniprotkb/E1BPP5" } ], "pmid": "" }, { "name": "granulocyte chemotaxis", "id": "GO:0071621", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071621", "evidence": [ { "database": "UniProtKB", "id": "E1BPP5", "url": "https://www.uniprot.org/uniprotkb/E1BPP5" } ], "pmid": "" }, { "name": "defense response to fungus", "id": "GO:0050832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050832", "evidence": [ { "database": "UniProtKB", "id": "E1BPP5", "url": "https://www.uniprot.org/uniprotkb/E1BPP5" } ], "pmid": "" }, { "name": "interleukin-17A-mediated signaling pathway", "id": "GO:0038173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038173", "evidence": [ { "database": "UniProtKB", "id": "E1BPP5", "url": "https://www.uniprot.org/uniprotkb/E1BPP5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "interleukin-17 receptor activity", "id": "GO:0030368", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030368", "evidence": [ { "database": "UniProtKB", "id": "E1BPP5", "url": "https://www.uniprot.org/uniprotkb/E1BPP5" } ], "pmid": "" }, { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "E1BPP5", "url": "https://www.uniprot.org/uniprotkb/E1BPP5" } ], "pmid": "" }, { "name": "coreceptor activity", "id": "GO:0015026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015026", "evidence": [ { "database": "UniProtKB", "id": "E1BPP5", "url": "https://www.uniprot.org/uniprotkb/E1BPP5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 213, "end_pos": 215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPP5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 716, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": 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"start_pos": 253, "end_pos": 255 }, { "start_pos": 263, "end_pos": 265 }, { "start_pos": 349, "end_pos": 351 }, { "start_pos": 406, "end_pos": 408 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", 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"XP_005215955", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215955" } ] }, { "name": "MRVI1", "type": "synonym", "evidence": [ { "id": "XP_005215955", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215955" } ] } ], "protein_names": [ { "name": "Inositol 1,4,5-triphosphate receptor associated 1", "type": "synonym", "evidence": [ { "id": "F1MH42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH42/entry#names_and_taxonomy" } ] }, { "name": "inositol 1,4,5-triphosphate receptor associated 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005215955", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215955" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MH42", "url": "https://www.uniprot.org/uniprotkb/F1MH42" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IRAG1", "url": "https://www.uniprot.org/uniprotkb/F1MH42", "locus": { "chromosome": "15", "start_pos": 42098627, "end_pos": 41972410, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007129", "url": "https://www.ensembl.org/id/ENSBTAG00000007129" } ] } } ], "crossref": [ { "id": "F1MH42", "url": "https://alphafold.ebi.ac.uk/entry/F1MH42", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007129", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007129", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "281918", "url": "https://www.ncbi.nlm.nih.gov/gene/281918", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MH42", "url": "https://www.orthodb.org/?gene=F1MH42", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MYA5", "url": "https://www.orthodb.org/?gene=F1MYA5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15352", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15352", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15352:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15352:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05781", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05781", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418457", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418457", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005215955", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215955", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ96", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ96", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ96-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ96-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFI4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFI4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH42", "url": "https://www.uniprot.org/uniprotkb/F1MH42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH42-1", "url": "https://www.uniprot.org/uniprotkb/F1MH42-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MYA5", "url": "https://www.uniprot.org/uniprotkb/F1MYA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MYA5-1", "url": "https://www.uniprot.org/uniprotkb/F1MYA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKAPQSEERLAGGGKGNNSVLACGAQASWSIFGADAAEVPGTRSHSRQEAAMPHIPEDEEPPGEPQAAQSPAGQDPATTGISCSPPTIILTGDASSPEGETDKNPVNRAHSPHRRLSHRHLKVSTASLTSVDPAGHVIDLVNDQLPDISISEEDKKKNLALLEEAKLVSERFLTRRGRKSRSSPGESSPAVSPNLSPGASPASSQSNSLTVPTPPGLDVCSGPPSPLPGAPPQQKGDEAEVPSPHLGESNVLKGLADRKQNDQRTLSQGRLTARSPTVEKSKEITIEHKENFDPLQRPEAIPKGPASGPGSGGKMALNSPQPGPVESELGKPLAKTAKEGNPLPRGPTQGSGGVAPQASQGKSTVGEPAGSKVGSKAELWPPTSRPPLLRGVSWDSGPEEPGPRLQKVLAKLPLAEEEKRFTGKAGSKLAKAPGLKDFQIQVQPVRMQKLTKLREEHILLRNQNLVGLKLPELSEAAEQEKGHPSELSSAIEEEESKGGLDVMPNISDVLLRKLRVHKSLPGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSASLWHHCEHRETYQKLLEDIAVLHRLAARLSSRAEMVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTARSMSLSLGKNMPRRRVSVAVVPKFNILNLPGQSPSSSPIPSLPALSESSNGKGNPPVSSALPALLENGKTNGDPDCEASASVPTPSCLEGISQEAKARMEEEAYNKGYQEGLKKTKELQGLREEEEEQKSESPEEPEEAAETEEEEKEQRSSKLEELVHFLQVMYPKLCQHWQVIWMMAAAMLVLTVVLGLYGSHNSCVEQADGSLGKSTCSAAQRDSWWSSGLQHEQPTEQ", "length": 912, "header": "tr|F1MH42-1|F1MH42_BOVIN Isoform 1 of Inositol 1,4,5-triphosphate receptor associated 1 OS=Bos taurus OX=9913 GN=IRAG1 PE=4 SV=2 CANONICAL=F1MH42-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZ96-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ96/entry", "sequence": { "sequence": "MASSRPVEDPATTGISCSPPTIILTGDASSPEGETDKNPVNRAHSPHRRLSHRHLKVSTASLTSVDPAGHVIDLVNDQLPDISISEEDKKKNLALLEEAKLVSERFLTRRGRKSRSSPGESSPAVSPNLSPGASPASSQSNSLTVPTPPGLDVCSGPPSPLPGAPPQKGDEAEVPSPHLGESNVLKGLADRKQNDQRTLSQGRLTARSPTVEKSKEITIEHKENFDPLQRPEAIPKGPASGPGSGGKMALNSPQPGPVESELGKPLAKTAKEGNPLPRGPTQGSGGVAPQASQGKSTVGEPAGSKVGSKAELWPPTSRPPLLRGVSWDSGPEEPGPRLQKVLAKLPLAEEEKRFTGKAGSKLAKAPGLKDFQIQVQPVRMQKLTKLREEHILLRNQNLVGLKLPELSEAAEQEKGHPSELSSAIEEEESKGGLDVMPNISDVLLRKLRVHKSLPGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSASLWHHCEHRETYQKLLEDIAVLHRLAARLSSRAEMVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTARSMSLSLGKNMPRRRVSVAVVPKFNILNLPGQSPSSSPIPSLPALSESSNGKGNPPVSSALPALLENGKTNGDPDCEASASVPTPSCLEGISQEAKARMEEEAYNKGYQEGLKKTKELQGLREEEEEQKSESPEEPEEAAETEEEEKEQRSSKLEELVHFLQVMYPKLCQHWQVIWMMAAAMLVLTVVLGLYGSHNSCVEQADGSLGKSTCSAAQRDSWWSSGLQHEQPTEQ", "length": 844, "header": "tr|A0A3Q1LZ96-1|F1MH42_BOVIN Computationally mapped isoform of Inositol 1,4,5-triphosphate receptor associated 1 OS=Bos taurus OX=9913 GN=IRAG1 PE=4 SV=1 CANONICAL=F1MH42-1" }, "locus": { "chromosome": "15", "start_pos": 42095337, "end_pos": 42035503, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084912.2", "url": "https://www.ensembl.org/id/ENSBTAT00000084912.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061020.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061020.1" } ] } }, { "isoform_ac": "A0A3Q1MFI4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFI4/entry", "sequence": { "sequence": "MVKAPQSEERLAGGGKGNNSVLACGAQASWSIFGADAAEVPGTRSHSRQEAAMPHIPEDEEPPGEPQAAQSPAGQDPATTGISCSPPTIILTGDASSPEGETDKNPVNRAHSPHRRLSHRHLKVSTASLTSVDPAGHVIDLVNDQLPDISISEEDKKKNLALLEEAKLVSERFLTRRGRKSRSSPGESSPAVSPNLSPGASPASSQSNSLTVPTPPGLDVCSGPPSPLPGAPPQKGDEAEVPSPHLGESEHILLRNQNLVGLKLPELSEAAEQEKGHPSELSSAIEEEESKGGLDVMPNISDVLLRKLRVHKSLPGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSASLWHHCEHRETYQKLLEDIAVLHRLAARLSSRAEMVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTARSMSLSLGKNMPRRRVSVAVVPKFNILNLPGQSPSSSPIPSLPALSESSNGKGNPPVSSALPALLENGKTNGDPDCEASASVPTPSCLEGISQEAKARMEEEAYNKGYQEGLKKTKELQGLREEEEEQKSESPEEPEEAAETEEEEKEQRSSKLEELVHFLQVMYPKLCQHWQVIWMMAAAMLVLTVVLGLYGSHNSCVEQADGSLGKSTCSAAQRDSWWSSGLQHEQPTEQ", "length": 705, "header": "tr|A0A3Q1MFI4-1|F1MH42_BOVIN Computationally mapped isoform of Inositol 1,4,5-triphosphate receptor associated 1 OS=Bos taurus OX=9913 GN=IRAG1 PE=4 SV=2 CANONICAL=F1MH42-1" }, "locus": { "chromosome": "15", "start_pos": 42095337, "end_pos": 41972699, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075172.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075172.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072970.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072970.2" } ] } }, { "isoform_ac": "F1MH42-1", "url": "https://www.uniprot.org/uniprotkb/F1MH42/entry", "sequence": { "sequence": "MVKAPQSEERLAGGGKGNNSVLACGAQASWSIFGADAAEVPGTRSHSRQEAAMPHIPEDEEPPGEPQAAQSPAGQDPATTGISCSPPTIILTGDASSPEGETDKNPVNRAHSPHRRLSHRHLKVSTASLTSVDPAGHVIDLVNDQLPDISISEEDKKKNLALLEEAKLVSERFLTRRGRKSRSSPGESSPAVSPNLSPGASPASSQSNSLTVPTPPGLDVCSGPPSPLPGAPPQQKGDEAEVPSPHLGESNVLKGLADRKQNDQRTLSQGRLTARSPTVEKSKEITIEHKENFDPLQRPEAIPKGPASGPGSGGKMALNSPQPGPVESELGKPLAKTAKEGNPLPRGPTQGSGGVAPQASQGKSTVGEPAGSKVGSKAELWPPTSRPPLLRGVSWDSGPEEPGPRLQKVLAKLPLAEEEKRFTGKAGSKLAKAPGLKDFQIQVQPVRMQKLTKLREEHILLRNQNLVGLKLPELSEAAEQEKGHPSELSSAIEEEESKGGLDVMPNISDVLLRKLRVHKSLPGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSASLWHHCEHRETYQKLLEDIAVLHRLAARLSSRAEMVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTARSMSLSLGKNMPRRRVSVAVVPKFNILNLPGQSPSSSPIPSLPALSESSNGKGNPPVSSALPALLENGKTNGDPDCEASASVPTPSCLEGISQEAKARMEEEAYNKGYQEGLKKTKELQGLREEEEEQKSESPEEPEEAAETEEEEKEQRSSKLEELVHFLQVMYPKLCQHWQVIWMMAAAMLVLTVVLGLYGSHNSCVEQADGSLGKSTCSAAQRDSWWSSGLQHEQPTEQ", "length": 912, "header": "tr|F1MH42-1|F1MH42_BOVIN Isoform 1 of Inositol 1,4,5-triphosphate receptor associated 1 OS=Bos taurus OX=9913 GN=IRAG1 PE=4 SV=2 CANONICAL=F1MH42-1" }, "locus": { "chromosome": "15", "start_pos": 42095337, "end_pos": 41972699, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046140.6", "url": "https://www.ensembl.org/id/ENSBTAT00000046140.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043465.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043465.4" } ] } }, { "isoform_ac": "F1MYA5-1", "url": "https://www.uniprot.org/uniprotkb/F1MYA5/entry", "sequence": { "sequence": "MVKAPQSEERLAGGGKGNNSVLACGAQASWSIFGADAAEVPGTRSHSRQEAAMPHIPEDEEPPGEPQAAQSPAGQDPATTGISCSPPTIILTGDASSPEGETDKNPVNRAHSPHRRLSHRHLKVSTASLTSVDPAGHVIDLVNDQLPDISISEEDKKKNLALLEEAKLVSERFLTRRGRKSRSSPGESSPAVSPNLSPGASPASSQSNSLTVPTPPGLDVCSGPPSPLPGAPPQVMGLLWGFYNVLKGLADRKQNDQRTLSQGRLTARSPTVEKSKEITIEHKENFDPLQRPEAIPKGPASGPGSGGKMALNSPQPGPVESELGKPLAKTAKEGNPLPRGPTQGSGGVAPQASQGKSTVGEPAGSKVGSKAELWPPTSRPPLLRGVSWDSGPEEPGPRLQKVLAKLPLAEEEKRFTGKAGSKLAKAPGLKDFQIQVQPVRMQKLTKLREEHILLRNQNLVGLKLPELSEAAEQEKGHPSELSSAIEEEESKGGLDVMPNISDVLLRKLRVHKSLPGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSASLWHHCEHRETYQKLLEDIAVLHRLAARLSSRAEMVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTARSMSLSLGKNMPRRRVSVAVVPKFNILNLPGQSPSSSPIPSLPALSESSNGKGNPPVSSALPALLENGKTNGDPDCEASASVPTPSCLEGISQEAKARMEEEAYNKGYQEGLKKTKELQGLREEEEEQKSESPEEPEEAAETEEEEKEQRSSKLEELVHFLQVMYPKLCQHWQVIWMMAAAMLVLTVVLGLYGSHNSCVEQADGSLGKSTCSAAQRDSWWSSGLQHEQPTEQ", "length": 905, "header": "tr|F1MYA5-1|F1MH42_BOVIN Computationally mapped isoform of Inositol 1,4,5-triphosphate receptor associated 1 OS=Bos taurus OX=9913 GN=IRAG1 PE=4 SV=2 CANONICAL=F1MH42-1" }, "locus": { "chromosome": "15", "start_pos": 42095337, "end_pos": 41972699, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009387.8", "url": "https://www.ensembl.org/id/ENSBTAT00000009387.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009387.6", "url": "https://www.ensembl.org/id/ENSBTAP00000009387.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 349, "start_aa": "Thr", "end_pos": 349, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr349", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 764, "start_aa": "Thr", "end_pos": 764, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr764", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-418457", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418457", "resource": "Reactome", "description": "cGMP effects" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MH42", "url": "https://www.uniprot.org/uniprotkb/F1MH42" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MH42", "url": "https://www.uniprot.org/uniprotkb/F1MH42" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" }, { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 506, "end_pos": 508, "annotation": "n_glycosylation_sequon" }, { "start_pos": 546, "end_pos": 548, "annotation": "n_glycosylation_sequon" }, { "start_pos": 563, "end_pos": 565, "annotation": "n_glycosylation_sequon" }, { "start_pos": 664, "end_pos": 666, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MH42-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 912, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MH42-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MH42" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 349, 764 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 18, "end_pos": 20 }, { "start_pos": 195, "end_pos": 197 }, { "start_pos": 506, "end_pos": 508 }, { "start_pos": 546, "end_pos": 548 }, { "start_pos": 563, "end_pos": 565 }, { "start_pos": 664, "end_pos": 666 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MB52-1", "uniprot_ac": "F1MB52", "uniprot_id": "F1MB52_BOVIN", "mass": { "chemical_mass": 80373.0, "monoisotopic_mass": 80373.0 }, "refseq": { "ac": "NP_001178275", "name": "BBSome complex member BBS7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178275" }, "gene_names": [ { "name": "BBS7", "type": "recommended", "evidence": [ { "id": "F1MB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB52" } ] }, { "name": "BBS7", "type": "synonym", "evidence": [ { "id": "NP_001178275", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178275" } ] } ], "protein_names": [ { "name": "Bardet-Biedl syndrome 7 protein homolog", "type": "recommended", "evidence": [ { "id": "F1MB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB52/entry#names_and_taxonomy" } ] }, { "name": "BBSome complex member BBS7", "type": "synonym", "evidence": [ { "id": "NP_001178275", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178275" } ] } ], "function": [ { "annotation": "The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.", "evidence": [ { "database": "UniProtKB", "id": "F1MB52", "url": "https://www.uniprot.org/uniprotkb/F1MB52#function" }, { "database": "UniProtKB", "id": "PIRNR011091", "url": "https://www.uniprot.org/uniprotkb/PIRNR011091#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MB52", "url": "https://www.uniprot.org/uniprotkb/F1MB52" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BBS7", "url": "https://www.uniprot.org/uniprotkb/F1MB52", "locus": { "chromosome": "6", "start_pos": 3424379, "end_pos": 3385401, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004945", "url": "https://www.ensembl.org/id/ENSBTAG00000004945" } ] } } ], "crossref": [ { "id": "F1MB52", "url": "https://alphafold.ebi.ac.uk/entry/F1MB52", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004945", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004945", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100138953", "url": "https://www.ncbi.nlm.nih.gov/gene/100138953", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "6VBU", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6VBU&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "6VBV", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6VBV&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "6VNW", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6VNW&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "6VOA", "url": "https://www.ncbi.nlm.nih.gov/Structure/icn3d/?mmdbid=6VOA&bu=0", "database": "iCn3D", "categories": [ "3D Structure" ] }, { "id": "F1MB52", "url": "https://www.ebi.ac.uk/intact/interactors/id:F1MB52*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056334", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056334", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056335", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056335", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100138953", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138953", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KGEGCFK", "url": "https://omabrowser.org/oma/group/KGEGCFK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0R1", "url": "https://www.orthodb.org/?gene=A0A3Q1M0R1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MB52", "url": "https://www.orthodb.org/?gene=F1MB52", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16074", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16074", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16074:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16074:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "pdb_00006vbu", "url": "https://www.rcsb.org/structure/pdb_00006vbu", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00006vbv", "url": "https://www.rcsb.org/structure/pdb_00006vbv", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00006vnw", "url": "https://www.rcsb.org/structure/pdb_00006vnw", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "pdb_00006voa", "url": "https://www.rcsb.org/structure/pdb_00006voa", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VBU", "url": "https://www.rcsb.org/structure/6VBU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VBV", "url": "https://www.rcsb.org/structure/6VBV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VNW", "url": "https://www.rcsb.org/structure/6VNW", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6VOA", "url": "https://www.rcsb.org/structure/6VOA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF23349", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23349", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23360", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23360", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23361", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23361", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23743", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23743", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620922", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620922", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001178275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178275", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0R1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0R1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0R1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0R1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S189", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S189", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S189-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S189-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8W5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8W5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB52", "url": "https://www.uniprot.org/uniprotkb/F1MB52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB52-1", "url": "https://www.uniprot.org/uniprotkb/F1MB52-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDLNLNRADYLQVGVTSQKTMKLLPASKHRATQKVVVGDHDGIVMCFGMKKGEAVTVFKTLPGQKIARLELGGALNTPQEKIFIAAGSEIRGFTKRGKQFLSFETNLTESIKAMHISGSDLFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLLREVPVLACQDRVLRVLQGSDVTYEIEVPGPPTVLALHNGNGGDSGEDLLFGTSDGKLGLIQITTSKPIHKWEIRNEKKRGGILCVDSFDIVGDGVKDLLVGRDDGMVEVYGFDNANEPVLRFDHTLSESVTSIQGGCVGKDGYDEIVVSTYSGWITGLTTEPVHKESGPGEELKFNQEMQNKISSLRSELEQLQYKVLQEREKYQQSSQSSKAKSAVPSFSVNDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLDVDKNSAVVSFSSCDSESNDNFLLATYRCQANTTRLELKIRSIEGQYGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFSELHSWVVFCMPEVPEKPPAGECVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQVHEGNTNFLIPEYRCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDSYDQNALIAFFDAA", "length": 715, "header": "tr|F1MB52-1|F1MB52_BOVIN Isoform 1 of Bardet-Biedl syndrome 7 protein homolog OS=Bos taurus OX=9913 GN=BBS7 PE=1 SV=3 CANONICAL=F1MB52-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0R1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0R1/entry", "sequence": { "sequence": "MDLNLNRADYLQVGVTSQKTMKLLPASKHRATQKVVVGDHDGIVMCFGMKKGEAVTVFKTLPGQKIARLELGGALNTPQEKIFIAAGSEIRGFTKRGKQFLSFETNLTESIKAMHISGSDLFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLLREVPVLACQDRVLRVLQGSDVTYEIEVPGPPTVLALHNGNGGDSGEDLLFGTSDGKLGLIQITTSKPIHKWEIRNEKKRGGILCVDSFDIVGDGVKDLLVGRDDGMVEVYGFDNANEPVLRFDHTLSESVTSIQGGCVGKDGYDEIVVSTYSGWITGLTTEPVHKESGPGEELKFNQEMQNKISSLRSELEQLQYKVLQEREKYQQSSQSSKAKSAVPSFSVNDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLDVDKNSAVVSFSSCDSESNDNFLLATYRCQANTTRLELKIRSIEGQYGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQVHEGNTNFLIPEYRCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDSYDQNALIAFFDAA", "length": 660, "header": "tr|A0A3Q1M0R1-1|F1MB52_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 7 protein homolog OS=Bos taurus OX=9913 GN=BBS7 PE=1 SV=1 CANONICAL=F1MB52-1" }, "locus": { "chromosome": "6", "start_pos": 3423320, "end_pos": 3385519, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081394.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081394.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063577.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063577.1" } ] } }, { "isoform_ac": "A0AAA9S189-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S189/entry", "sequence": { "sequence": "MDLNLNRADYLQVGVTSQKTMKLLPASKHRATQKVVVGDHDGIVMCFGMKKGEAVTVFKTLPGQKIARLELGGALNTPQEKIFIAAGSEIRGFTKRGKQFLSFETNLTESIKAMHISGSDLFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLLREVPVLACQDRVLRVLQGSDVTYEIEVPGPPTVLALHNGNGGDSGEDLLFGTSDGKLGLIQITTSKPIHKWEIRNEKKRGGILCVDSFDIVGDGVKDLLVGRDDGMVEVYGFDNANEPVLRFDHTLSESVTSIQGGCVGKDGYDEIVVSTYSGWITGLTTEPVHKESGPGEELKFNQEMQNKISSLRSELEQLQYKVLQEREKYQQSSQSSKAKSAVPSFSVNDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLDVDKNSAVVSFSSCDSEIRSIEGQYGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFSELHSWVVFCMPEVPEKPPAGECVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQVHEGNTNFLIPEYRCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDSYDQNALIAFFDAA", "length": 693, "header": "tr|A0AAA9S189-1|F1MB52_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 7 protein homolog OS=Bos taurus OX=9913 GN=BBS7 PE=1 SV=1 CANONICAL=F1MB52-1" }, "locus": { "chromosome": "6", "start_pos": 3423320, "end_pos": 3385519, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099901.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099901.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075853.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075853.1" } ] } }, { "isoform_ac": "A0AAA9T8W5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W5/entry", "sequence": { "sequence": "MDLNLNRADYLQVGVTSQKTMKLLPASKHRATQKVVVGDHDGIVMCFGMKKGEAVTVFKTLPGQKIARLELGGALNTPQEKIFIAAGSEIRGFTKRGKQFLSFETNLTESIKAMHISGSDLFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLLREVPVLACQDRVLRVLQGSDVTYEIEVPGPPTVLALHNGNGGDSGEDLLFGTSDGKLGLIQITTSKPIHKWEIRNEKKRGGILCVDSFDIVGDGVKDLLVGRDDGMVEVYGFDNANEPVLRFDHTLSESVTSIQGGCVGKDGYDEIVVSTYSGWITGLTTEPVHKESGPGEELKFNQEMQNKISSLRSELEQLQYKVLQEREKYQQSSQSSKAKSAVPSFSVNDKFTLNKDDASYSLILEVQTAIDNVLIQIRSIEGQYGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFSELHSWVVFCMPEVPEKPPAGECVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQVHEGNTNFLIPEYRCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDSYDQNALIAFFDAA", "length": 668, "header": "tr|A0AAA9T8W5-1|F1MB52_BOVIN Computationally mapped isoform of Bardet-Biedl syndrome 7 protein homolog OS=Bos taurus OX=9913 GN=BBS7 PE=1 SV=1 CANONICAL=F1MB52-1" }, "locus": { "chromosome": "6", "start_pos": 3423320, "end_pos": 3385519, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110416.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110416.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093280.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093280.1" } ] } }, { "isoform_ac": "F1MB52-1", "url": "https://www.uniprot.org/uniprotkb/F1MB52/entry", "sequence": { "sequence": "MDLNLNRADYLQVGVTSQKTMKLLPASKHRATQKVVVGDHDGIVMCFGMKKGEAVTVFKTLPGQKIARLELGGALNTPQEKIFIAAGSEIRGFTKRGKQFLSFETNLTESIKAMHISGSDLFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLLREVPVLACQDRVLRVLQGSDVTYEIEVPGPPTVLALHNGNGGDSGEDLLFGTSDGKLGLIQITTSKPIHKWEIRNEKKRGGILCVDSFDIVGDGVKDLLVGRDDGMVEVYGFDNANEPVLRFDHTLSESVTSIQGGCVGKDGYDEIVVSTYSGWITGLTTEPVHKESGPGEELKFNQEMQNKISSLRSELEQLQYKVLQEREKYQQSSQSSKAKSAVPSFSVNDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLDVDKNSAVVSFSSCDSESNDNFLLATYRCQANTTRLELKIRSIEGQYGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFSELHSWVVFCMPEVPEKPPAGECVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQVHEGNTNFLIPEYRCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDSYDQNALIAFFDAA", "length": 715, "header": "tr|F1MB52-1|F1MB52_BOVIN Isoform 1 of Bardet-Biedl syndrome 7 protein homolog OS=Bos taurus OX=9913 GN=BBS7 PE=1 SV=3 CANONICAL=F1MB52-1" }, "locus": { "chromosome": "6", "start_pos": 3423320, "end_pos": 3385519, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006505.8", "url": "https://www.ensembl.org/id/ENSBTAT00000006505.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006505.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006505.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 473, "start_aa": "Thr", "end_pos": 473, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr473", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Structure and activation mechanism of the BBSome membrane protein trafficking complex.", "journal": "Elife", "date": "2020", "authors": "Singh SK, Gui M, Koh F, Yip MC, Brown A", "evidence": [ { "database": "UniProtKB", "id": "F1MB52", "url": "https://www.uniprot.org/uniprotkb/F1MB52" } ], "reference": [ { "type": "PubMed", "id": "31939736", "url": "https://glygen.org/publication/PubMed/31939736" } ] }, { "title": "Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes.", "journal": "Elife", "date": "2020", "authors": "Yang Shuang, Bahl Kriti, Chou Hui-Ting, Woodsmith Jonathan, Stelzl Ulrich, Walz Thomas, Nachury Maxence V", "evidence": [ { "database": "UniProtKB", "id": "F1MB52", "url": "https://www.uniprot.org/uniprotkb/F1MB52" } ], "reference": [ { "type": "PubMed", "id": "32510327", "url": "https://glygen.org/publication/PubMed/32510327" } ] } ], "pathway": [ { "id": "bta:100138953", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138953", "resource": "KEGG Pathway" }, { "id": "R-BTA-5620922", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620922", "resource": "Reactome", "description": "BBSome-mediated cargo-targeting to cilium" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7F5M3-1", "protein_name": "Bardet-Biedl syndrome 7 protein homolog", "gene_name": "Bbs7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDLTLSRADYLQVGVTSQKTMKLLPASKQKATQKVVVGDQDGVVMCFGMKKGEAVPVFKTLPGQKISRLELGGVLNTPQEKIFLAAGSEIRGFTKRGKQFLSFETNLTESIKAMYISGSDLFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRMMPVLACQDRVLRVLQGSDVMYEIEVPGPPTVLALHNGDGGDSGEGLLFGTSDGKLGLIQITISKPIHKWEIRNDKKRGGILCIDSFDIMGDGVKDLLVGRDDGMVEVYSFENANEPVLRFDQMLSESITSLQGGCVGKDGYDEIVLATYSGWITGLTTEPTHKESGPGEELKLNQEMQNKISSLRSELEHLQFKVLQERENYQQSSQSSKAKSTVPSFSINDKFTLNKDDASYSLVLEVQTAIDNVLIQSDVPIDLLDVDKNSAVVSFSSCDTESNDNFLLATYRCQANTTRLELKIRSIEGQYGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLIGQFSFAEVHSWVVFCLPEVPEKPPAGESATFYFQNTFLDTQLECVYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQVHEGNTNFLIPEYRCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPILLEILDSYDQNTLISFFDAA", "length": 715 }, "evidence": [ { "id": "F1MB52", "url": "https://omabrowser.org/oma/group/F1MB52/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1BXI4-1", "protein_name": "Bardet-Biedl syndrome 7 protein homolog", "gene_name": "BBS7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEVSLARVDYLQVGVTAQKTMRLLPASGRRATQKVVVGDQDGVITCFGIKKGEPVTVFKTLPGPKIARLELGGALNTPQEKVFVATGSEVRGFTKRGKQFLSFETNLTEDIKAMHISGADLFLCASYIYNHYCDCKDKHYYLSRDKINDVLCLPVDKVNCITPVLACQDRVLRVLQGSDLLYEVEVPGPPTVLALNNGDGGDSGEEIVYGTSDGKLGLIQITGSASVPKWEIENEKKRGGILCIDSFDILRDGVKELLVGRDDGVLEIYSFESADDPVLRYDYVLSESISSIQGGCVGKDGYDEVLACTYSGWLTGLTTELAYREGGSGEELKLSQEMQSKISSLRNEVEHLQMKVLGEREKYQQSSQSSSAVSSVPAFSVNDKFTLNKDDASYSLILEVQAAIDIILVQSDVPVDLLDVDKNSAVVSFSNCDSDPNGNCLLATYRCQANTTRLELKIRSIEGRYGTLQAYVTPRIQPKTCQVYQYQIKPLSLHQRTHSIDHDRPMNTLTLKGQFSFAEIHSWVVFCLPEVPERTPPGESVTFYFQNTFLGTQLESTYRIGEGCFKSDNISTISILKDVLSKEATKRKINLNISFDINEESVRHTLKLIHPKLEYQQLLAKKVHLIDALRELQVQEGNVDFLVPEYRSILEEADQLLEEYKKQPAHLERLYGMITDLFIDKFKFRGTNVKSKVPLLLELLDGCEQERLVAFFEAAS", "length": 716 }, "evidence": [ { "id": "F1MB52", "url": "https://omabrowser.org/oma/group/F1MB52/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8IWZ6-1", "protein_name": "BBSome complex member BBS7", "gene_name": "BBS7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDLILNRMDYLQVGVTSQKTMKLIPASRHRATQKVVIGDHDGVVMCFGMKKGEAAAVFKTLPGPKIARLELGGVINTPQEKIFIAAASEIRGFTKRGKQFLSFETNLTESIKAMHISGSDLFLSASYIYNHYCDCKDQHYYLSGDKINDVICLPVERLSRITPVLACQDRVLRVLQGSDVMYAVEVPGPPTVLALHNGNGGDSGEDLLFGTSDGKLALIQITTSKPVRKWEIQNEKKRGGILCIDSFDIVGDGVKDLLVGRDDGMVEVYSFDNANEPVLRFDQMLSESVTSIQGGCVGKDSYDEIVVSTYSGWVTGLTTEPIHKESGPGEELKINQEMQNKISSLRNELEHLQYKVLQERENYQQSSQSSKAKSAVPSFGINDKFTLNKDDASYSLILEVQTAIDNVLIQSDVPIDLLDVDKNSAVVSFSSCDSESNDNFLLATYRCQADTTRLELKIRSIEGQYGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVVFCLPEVPEKPPAGECVTFYFQNTFLDTQLESTYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQIHEGNTNFLIPEYHCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPLLLEILDSYDQNALISFFDAA", "length": 715 }, "evidence": [ { "id": "F1MB52", "url": "https://omabrowser.org/oma/group/F1MB52/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K2G4-1", "protein_name": "BBSome complex member BBS7", "gene_name": "Bbs7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDLTLSRADYLQVGVTSQKTMKLLPTSRQRATQKVVVGDQDGVVICFGVKKGEAVPVFKTLPGQKISRLELGGAVNTPQEKIFIAAGSEIRGFTKRGKQFLSFETNLTESIKAMYISGSDLFLSASYIYNHYCDCKDQNYYLSGDKINDVICLPVEKLSRVTPVLACQDRVLRVLQGSDVMYEIEVPGPPTVLALHNGDGGDSGEGLLFGTSDGRLGLIQITTSKPIHKWEIRNDKKRGGILCVDSFDIMGDGVKDLLVGRDDGMVEVYSFENANEPVLRFDQMLSESVTSIQGGCVGKDGYDEIVLATYSGWVTGLTTEPTHKESGPGEELKLNQEMQNKISSLRSEIEHLQFKVLQERENYQQSSQSSQAKSTVPSFSINDKFTLNKEDASYSLVLEVRTAIDNVLIQSDVPIDLLDVDKNSAVVSFSSCDTESNDNFLLATYRCQANTTRLELKIRSIEGQYGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNTLTLTGQFSFAEVHSWVVFCLPEVPEKPPAGECATFYFQNTFLDTQLECVYRKGEGVFKSDNISTISILKDVLSKEATKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQLIDALKELQVHEGNTDFLTPEYRCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKFKFKGTNVKTKVPMLLEILDSYDQNTLISFFDAA", "length": 715 }, "evidence": [ { "id": "F1MB52", "url": "https://omabrowser.org/oma/group/F1MB52/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "non-motile cilium assembly", "id": "GO:1905515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905515", "evidence": [ { "database": "UniProtKB", "id": "F1MB52", "url": "https://www.uniprot.org/uniprotkb/F1MB52" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1MB52", "url": "https://www.uniprot.org/uniprotkb/F1MB52" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "F1MB52", "url": "https://www.uniprot.org/uniprotkb/F1MB52" } ], "pmid": "" }, { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "F1MB52", "url": "https://www.uniprot.org/uniprotkb/F1MB52" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "BBSome", "id": "GO:0034464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034464", "evidence": [ { "database": "UniProtKB", "id": "F1MB52", "url": "https://www.uniprot.org/uniprotkb/F1MB52" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MB52", "url": "https://www.uniprot.org/uniprotkb/F1MB52" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "F1MB52", "url": "https://www.uniprot.org/uniprotkb/F1MB52" } ], "pmid": "" }, { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "F1MB52", "url": "https://www.uniprot.org/uniprotkb/F1MB52" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "F1MB52", "url": "https://www.uniprot.org/uniprotkb/F1MB52" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 106, "end_pos": 108, "annotation": "n_glycosylation_sequon" }, { "start_pos": 450, "end_pos": 452, "annotation": "n_glycosylation_sequon" }, { "start_pos": 569, "end_pos": 571, "annotation": "n_glycosylation_sequon" }, { "start_pos": 592, "end_pos": 594, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MB52-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 715, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MB52-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MB52" }, { "pdb_id": "6vbu", "pdb_chain": "7", "start_pos": 1, "end_pos": 715, "overlap": "1.0", "method": "Electron_Microscopy", "type": "experimental", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/6vbu.pdb", "url_external": "https://www.rcsb.org/structure/6vbu" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB52" }, { "id": "PF23360", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23360" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BBS7 GAE", "eco_id": "ECO_0000259", "start_pos": 377, "end_pos": 486, "start_aa": "Pro", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB52" }, { "id": "PF23743", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23743" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BBS7 beta-propeller", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 319, "start_aa": "Met", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB52" }, { "id": "PF23349", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23349" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BBS7 helical hairpin", "eco_id": "ECO_0000259", "start_pos": 599, "end_pos": 712, "start_aa": "Glu", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB52" }, { "id": "PF23361", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23361" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BBS7 platform", "eco_id": "ECO_0000259", "start_pos": 494, "end_pos": 596, "start_aa": "His", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 473 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 106, "end_pos": 108 }, { "start_pos": 450, "end_pos": 452 }, { "start_pos": 569, "end_pos": 571 }, { "start_pos": 592, "end_pos": 594 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGH2-1", "uniprot_ac": "F1MGH2", "uniprot_id": "F1MGH2_BOVIN", "mass": { "chemical_mass": 60656.0, "monoisotopic_mass": 60656.0 }, "refseq": { "ac": "NP_001291942", "name": "60 kDa lysophospholipase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291942" }, "gene_names": [ { "name": "ASPG", "type": "recommended", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "name": "ASPG", "type": "synonym", "evidence": [ { "id": "NP_001291942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291942" } ] } ], "protein_names": [ { "name": "60 kDa lysophospholipase", "type": "recommended", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2/entry#names_and_taxonomy" } ] }, { "name": "3.1.1.47", "type": "synonym", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2/entry#names_and_taxonomy" } ] }, { "name": "3.1.1.5", "type": "synonym", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2/entry#names_and_taxonomy" } ] }, { "name": "3.5.1.1", "type": "synonym", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2/entry#names_and_taxonomy" } ] }, { "name": "60 kDa lysophospholipase", "type": "synonym", "evidence": [ { "id": "NP_001291942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291942" } ] }, { "name": "Lysophospholipase-transacylase", "type": "synonym", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2/entry#names_and_taxonomy" } ] }, { "name": "asparaginase homolog", "type": "synonym", "evidence": [ { "id": "NP_001291942", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291942" } ] } ], "function": [ { "annotation": "Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities. Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid.", "evidence": [ { "database": "UniProtKB", "id": "F1MGH2", "url": "https://www.uniprot.org/uniprotkb/F1MGH2#function" }, { "database": "UniProtKB", "id": "ARBA00054432", "url": "https://www.uniprot.org/uniprotkb/ARBA00054432#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MGH2", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASPG", "url": "https://www.uniprot.org/uniprotkb/F1MGH2", "locus": { "chromosome": "21", "start_pos": 68641438, "end_pos": 68618021, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017194", "url": "https://www.ensembl.org/id/ENSBTAG00000017194" } ] } } ], "crossref": [ { "id": "F1MGH2", "url": "https://alphafold.ebi.ac.uk/entry/F1MGH2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017194", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017194", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08963", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08963", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505486", "url": "https://www.ncbi.nlm.nih.gov/gene/505486", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027473", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027473", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027474", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027474", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027475", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027475", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505486", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505486", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EWDLANK", "url": "https://omabrowser.org/oma/group/EWDLANK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M1F9", "url": "https://www.orthodb.org/?gene=A0A3Q1M1F9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MGH2", "url": "https://www.orthodb.org/?gene=F1MGH2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11707", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11707", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11707:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11707:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00710", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00710", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17763", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17763", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001291942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291942", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "15177", "url": "https://www.rhea-db.org/rhea/15177", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "17777", "url": "https://www.rhea-db.org/rhea/17777", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "21016", "url": "https://www.rhea-db.org/rhea/21016", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40435", "url": "https://www.rhea-db.org/rhea/40435", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40807", "url": "https://www.rhea-db.org/rhea/40807", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40827", "url": "https://www.rhea-db.org/rhea/40827", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40879", "url": "https://www.rhea-db.org/rhea/40879", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40887", "url": "https://www.rhea-db.org/rhea/40887", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40891", "url": "https://www.rhea-db.org/rhea/40891", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40895", "url": "https://www.rhea-db.org/rhea/40895", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40899", "url": "https://www.rhea-db.org/rhea/40899", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40903", "url": "https://www.rhea-db.org/rhea/40903", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40907", "url": "https://www.rhea-db.org/rhea/40907", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40959", "url": "https://www.rhea-db.org/rhea/40959", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "41320", "url": "https://www.rhea-db.org/rhea/41320", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "41352", "url": "https://www.rhea-db.org/rhea/41352", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M1F9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1F9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1F9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1F9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGH2", "url": "https://www.uniprot.org/uniprotkb/F1MGH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGH2-1", "url": "https://www.uniprot.org/uniprotkb/F1MGH2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARAAGPERRLLAVYTGGTIGMRSERGVLVPGRGLAAVLKMLPMFHDEEHARARGLPEDTLVLPPASPDQRVIYTVLECQPLFDSSDMTITEWVQIAQTIESHYARYDGFVVIHGTDTMAFAASVLSFVLENLQKTVILTGAQVPIHALWNDGRENLLGALLLAGQYVIPEVCLFFQNQLFRGNRVTKVDARRFAAFCSPNLPPLATVGADVTISQELVRRVRGQGRLVVHSSMERNVGLLRLYPGIPASLVRAFLQPPMKGVVMETFGSGNGPTKPDLLQELRAAAERGLIIVNCTHCLQGAVTSDYGAGMALSGSGTVSGFDMTSEAALAKLSYVLGLPGLSLDGRKELLARDLRGEMTPPTVDEPRPSLRGGVLGRGVAQLLSLRQEADEVWDALVPSLACAAAYVGDLEALQVLVELGSDRSLEDFSGQTPLHAAARAGQAGAVTMLLQRGLDVNARDKGGLSPLLLAVGGRHRDVIGLLRAAGACLSPQELEDSGTELCRLASRADCEGLRAWGQAGADLRQPGYDGRSALHVAEVAGNLEVVALLQNLRGGAGDQAPGPEVLPGV", "length": 571, "header": "tr|F1MGH2-1|F1MGH2_BOVIN Isoform 1 of 60 kDa lysophospholipase OS=Bos taurus OX=9913 GN=ASPG PE=3 SV=3 CANONICAL=F1MGH2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1F9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1F9/entry", "sequence": { "sequence": "MARAAGPERRLLAVYTGGTIGMRSERGVLVPGRGLAAVLKMLPMFHDEEHARARGLPEDTLVLPPASPDQRVIYTVLECQPLFDSSDMTITEWVQIAQTIEVPIHALWNDGRENLLGALLLAGQYVIPEVCLFFQNQLFRGNRVTKVDARRFAAFCSPNLPPLATVGADVTISQELVRRVRGQGRLVVHSSMERNVGLLRLYPGIPASLVRAFLQPPMKGVVMETFGSGNGPTKPDLLQELRAAAERGLIIVNCTHCLQGAVTSDYGAGMALSGSGTVSGFDMTSEAALAKLSYVLGLPGLSLDGRKELLARDLRGEMTPPTVDEPRPSLRGGVLGRGVAQLLSLRQEADEVWDALVPSLACAAAYVGDLEALQVLVELGSDRSLEDFSGQTPLHAAARAGQAGAVTMLLQRGLDVNARDKGGLSPLLLAVGGRHRDVIGLLRAAGACLSPQELEDSGTELCRLASRADCEGLRAWGQAGADLRQPGYDGRSALHVAEVAGNLEVVALLQNLRGGAGDQAPGPEVLPGV", "length": 529, "header": "tr|A0A3Q1M1F9-1|F1MGH2_BOVIN Computationally mapped isoform of 60 kDa lysophospholipase OS=Bos taurus OX=9913 GN=ASPG PE=3 SV=2 CANONICAL=F1MGH2-1" }, "locus": { "chromosome": "21", "start_pos": 68641341, "end_pos": 68618078, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069460.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069460.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063787.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063787.2" } ] } }, { "isoform_ac": "F1MGH2-1", "url": "https://www.uniprot.org/uniprotkb/F1MGH2/entry", "sequence": { "sequence": "MARAAGPERRLLAVYTGGTIGMRSERGVLVPGRGLAAVLKMLPMFHDEEHARARGLPEDTLVLPPASPDQRVIYTVLECQPLFDSSDMTITEWVQIAQTIESHYARYDGFVVIHGTDTMAFAASVLSFVLENLQKTVILTGAQVPIHALWNDGRENLLGALLLAGQYVIPEVCLFFQNQLFRGNRVTKVDARRFAAFCSPNLPPLATVGADVTISQELVRRVRGQGRLVVHSSMERNVGLLRLYPGIPASLVRAFLQPPMKGVVMETFGSGNGPTKPDLLQELRAAAERGLIIVNCTHCLQGAVTSDYGAGMALSGSGTVSGFDMTSEAALAKLSYVLGLPGLSLDGRKELLARDLRGEMTPPTVDEPRPSLRGGVLGRGVAQLLSLRQEADEVWDALVPSLACAAAYVGDLEALQVLVELGSDRSLEDFSGQTPLHAAARAGQAGAVTMLLQRGLDVNARDKGGLSPLLLAVGGRHRDVIGLLRAAGACLSPQELEDSGTELCRLASRADCEGLRAWGQAGADLRQPGYDGRSALHVAEVAGNLEVVALLQNLRGGAGDQAPGPEVLPGV", "length": 571, "header": "tr|F1MGH2-1|F1MGH2_BOVIN Isoform 1 of 60 kDa lysophospholipase OS=Bos taurus OX=9913 GN=ASPG PE=3 SV=3 CANONICAL=F1MGH2-1" }, "locus": { "chromosome": "21", "start_pos": 68641341, "end_pos": 68618078, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022852.8", "url": "https://www.ensembl.org/id/ENSBTAT00000022852.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022852.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022852.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 275, "start_aa": "Thr", "end_pos": 275, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr275", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:505486", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505486", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480JNH1-1", "protein_name": "asparaginase", "gene_name": "ASPG", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARAAGRERRLLAIYTGGTLGMRSERGVLVPGKGLAAVLRTLPMFHDEEHARARGLPEDTLVLPPAGPDQRVVYTVLECQPLFDSSDMTISEWVDIAQTIERHYEQYHGFVVIHGTDTMAFAASTLSFVLENLQKPVILTGAQVPIHALWNDGRENLLGALLLAGQYVIPEVCLFFQNQLFRGNRVTKVDAHRFSAFCSPNLPPLATVGADVTINHELVRRVRGRGRLVVHSCMERDVGLLRLYPGIPAALVRAFLQPPLKGVVLETFGSGNGPTKAGLLQELRAAAERGLVIVNCTHCLQGAVTSTYGAGMAMAGAGTVSGSDMTSEAALAKLSYVLGLPGLSLDGRKELLARDLRGEMTPPAVDLLWPSLQGSKLGRGVAQLLSLSQEADAVREVLAPSLACAAAHAGDLEALRALEELGSDLSLEDFGGQTPLHAAARGGHVGTVTMLLQRGLDANARDKDGLSPLLLAVRGRHQGVIGLLRAAGGCLSPQELEDSGTELCRLASRGDREGLRAWWQAGVDLQQPGYDGRSALCIAEAAGNLEVVSLLQSLQAGGDGQALGSEVLPAV", "length": 571 }, "evidence": [ { "id": "F1MGH2", "url": "https://omabrowser.org/oma/group/F1MGH2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0JNU3-1", "protein_name": "60 kDa lysophospholipase", "gene_name": "Aspg", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARAMGPERRLLAIYTGGTIGMRSEGGVLVPGRGLAAVLKTLHMFHDEEYAQAHSLPEDTLVLPPASPDQRIIYTVLECQPLFDSSDMTITEWVQIAQTIERHYAQYQGFVVIHGTDTMAFAASVLSFMLENLQKPVVLTGAQVPIHALWSDGRENLLGALLMAGQYVIPEVCLFFQNQLFRGNRTTKVDARRFAAFCSPNLPPLATVGADVTINRELVRKACGKSHLVVHSSMEPDVGLLRLYPGIPASLVRTFLQPPLKGVVMETFGSGNGPTKPDLLQELRVAAEQGLIIVNCTHCLQGAVTSDYASGMAMAGAGIVSGFDMTSEAALAKLSYVLGQPGLSLNDRKKLLAKDLRGEMTLPATDVLLQDGMLGCRVAWLLSMNGSQEADTMKDVLLPGLALAAAHAGDLDTLQAFVELDRDLNLKDYSGQTPLHVAARRGHAAVVTMLLQRGADVDARNEDGQSPLLLAVRGRHQSVIGLLRAAGARLSPQELEDVGTELCRLASRGDSEGLRAWWQAGADLGQPDYDGHCALQVAEAAGNADVVALLQSFKDSVCAQPQPH", "length": 564 }, "evidence": [ { "id": "F1MGH2", "url": "https://omabrowser.org/oma/group/F1MGH2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O88202-1", "protein_name": "60 kDa lysophospholipase", "gene_name": "Aspg", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARATGPEQRLLAIYTGGTIGMRSEGGVLVPGRGLAAVLRTLHMLHDEEYARAHSLPEDTLVLPPASSDQRIIYKVLECQPLFDSSDMTITEWVQIAQTIERHYTQYQGFVVIHGTDTMAFAASVLSFMLENLQKPVILTGAQVPIHELWSDGRENLLGALLMAGQYVIPEVCLFFQNQLFRGNRTTKVDARRFAAFCSPNLPPLATVGADVTINRELVRKASWKSHLVVHSNMEPDVGLLRLYPGIPASLVRTFLQPPLKGVVMETFGSGNGPTKPDLIQELRAAAERGLIIVNCTHCLQGAVTSDYAPGMAMAGAGIISGFDMTSEAALAKLSYVLGQPGLSLSDRKKLLAKDLRGEMTLPTTDDLLGDDMLGCRATWLLSMNGSQDADAMKDVLLPGLALAAAHAGDLDTLQAFVELGRDLNLKDYSGQTPLHVAARRGHASVVAMLLQKGVDVDACNEDGQSPLLLAVRGRHQSVIRLLRAAGAHLSPQELEDVGTELCRLASRADSEGLRAWWQAGADLGQPDYDGHCALQVAEAAGNADVVALLQSLEDRVSAQPQPH", "length": 564 }, "evidence": [ { "id": "F1MGH2", "url": "https://omabrowser.org/oma/group/F1MGH2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86U10-1", "protein_name": "60 kDa lysophospholipase", "gene_name": "ASPG", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARAVGPERRLLAVYTGGTIGMRSELGVLVPGTGLAAILRTLPMFHDEEHARARGLSEDTLVLPPASRNQRILYTVLECQPLFDSSDMTIAEWVCLAQTIKRHYEQYHGFVVIHGTDTMAFAASMLSFMLENLQKTVILTGAQVPIHALWSDGRENLLGALLMAGQYVIPEVCLFFQNQLFRGNRATKVDARRFAAFCSPNLLPLATVGADITINRELVRKVDGKAGLVVHSSMEQDVGLLRLYPGIPAALVRAFLQPPLKGVVMETFGSGNGPTKPDLLQELRVATERGLVIVNCTHCLQGAVTTDYAAGMAMAGAGVISGFDMTSEAALAKLSYVLGQPGLSLDVRKELLTKDLRGEMTPPSVEERRPSLQGNTLGGGVSWLLSLSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELEEAGTELCRLAYRADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFLQSLEGAVGAQAPCPEVLPGV", "length": 573 }, "evidence": [ { "id": "F1MGH2", "url": "https://omabrowser.org/oma/group/F1MGH2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VH61-1", "protein_name": "asparaginase", "gene_name": "Dmel\\CG8526", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPAAKCGCLKKEARVHVIYVGGTIGMIRNESGVLHTAPKVLARQLQEFPSCHDRNYTSKDNDGPMMVLPAVSGAPYRVLYDLIEFCPLMDSSCMGFCDWKRIANEVGKTYKSYDGFVILHGTDTLAYSASALAFMLESLNKPVVFTGAQIPIFEARSDGRENFLGALLIAGNYSIPEVLVFFGNKILRGCRSTKLNSDSFHALDSPNFAPLGRASVNIEINSRQIFRPCNIKPFSLHSELEKNVALLRIYPGISASVVQAILKEPTKGVVLQTFGAGNFPVNREDLLDELREAVHRGVIIVNITQCSAGMVANIYETSQGLMEVGVIPGYDMTQEAAFTKLAYVLSKPEWDIPNKKKVMLLSLRGELTTNKVAKINDIDLIEGVARTLHMSTAMERQQMCSTFYPALVAAAVTEGDVHKLGDLKQYGANLCDTNCDGRSAMHLACFLGKLNCVCFLISAGCPVNVHDRFNRTPLHEAIDTDNHDIINALLKNGAKLNDQPLVQAELLRALTERGKIKRLESFRLAGANLTLADRTGRTALHYACQLGNHEVVDYLLPHYENPYIKDELGMSPIDYAKAANHAHILTLMRFKEKELAKKDPCSCTQ", "length": 605 }, "evidence": [ { "id": "F1MGH2", "url": "https://omabrowser.org/oma/group/F1MGH2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "asparaginase activity", "id": "GO:0004067", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004067", "evidence": [ { "database": "UniProtKB", "id": "F1MGH2", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ], "pmid": "" }, { "name": "phosphatidylcholine lysophospholipase activity", "id": "GO:0004622", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004622", "evidence": [ { "database": "UniProtKB", "id": "F1MGH2", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ], "pmid": "" }, { "name": "1-alkyl-2-acetylglycerophosphocholine esterase activity", "id": "GO:0003847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003847", "evidence": [ { "database": "UniProtKB", "id": "F1MGH2", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ], "pmid": "" }, { "name": "acyltransferase activity", "id": "GO:0016746", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016746", "evidence": [ { "database": "UniProtKB", "id": "F1MGH2", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "F1MGH2", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 295, "end_pos": 297, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15177", "name": "", "equation": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T0P5-1", "Q8WMP9-1", "A4IFJ5-1", "A0A3Q1LV96-1", "Q3SZ79-1", "G3X6Z1-1", "F1MNU5-1", "E1BB89-1", "A0AAA9RYE9-1", "E1BC49-1", "F1MG30-1", "F1MGH2-1", "F1MFC1-1" ], "evidence": [ { "id": "15177", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15177" } ] }, { "id": "17777", "name": "", "equation": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P79106-1", "A0AAF7ABT5-1", "P68401-1", "Q28017-1", "Q29460-1", "Q3SZ16-1", "F1MGH2-1" ], "evidence": [ { "id": "17777", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17777" } ] }, { "id": "21016", "name": "", "equation": "L-asparagine + H2O = L-aspartate + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YQE1-1", "Q32LE5-1", "F1MGH2-1" ], "evidence": [ { "id": "21016", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21016" } ] }, { "id": "40435", "name": "", "equation": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T0P5-1", "Q8WMP9-1", "A4IFJ5-1", "A0A3Q1M5Z8-1", "A0A3Q1LV96-1", "Q3SZ79-1", "P30122-1", "Q3MHR0-1", "G3MWX2-1", "G3X6Z1-1", "A0AAA9S0E0-1", "E1BB89-1", "F1MGH2-1" ], "evidence": [ { "id": "40435", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40435" } ] }, { "id": "40807", "name": "", "equation": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (9Z)-octadecenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T0P5-1", "G3X6Z1-1", "F1MGH2-1" ], "evidence": [ { "id": "40807", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40807" } ] }, { "id": "40827", "name": "", "equation": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BB89-1", "F1MGH2-1" ], "evidence": [ { "id": "40827", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40827" } ] }, { "id": "40879", "name": "", "equation": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MGH2-1" ], "evidence": [ { "id": "40879", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40879" } ] }, { "id": "40887", "name": "", "equation": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + sn-glycerol 3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MGH2-1" ], "evidence": [ { "id": "40887", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40887" } ] }, { "id": "40891", "name": "", "equation": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = sn-glycero-3-phosphoethanolamine + hexadecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MGH2-1" ], "evidence": [ { "id": "40891", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40891" } ] }, { "id": "40895", "name": "", "equation": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08DW9-1", "F1MGH2-1" ], "evidence": [ { "id": "40895", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40895" } ] }, { "id": "40899", "name": "", "equation": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MGH2-1" ], "evidence": [ { "id": "40899", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40899" } ] }, { "id": "40903", "name": "", "equation": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MGH2-1" ], "evidence": [ { "id": "40903", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40903" } ] }, { "id": "40907", "name": "", "equation": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MGH2-1" ], "evidence": [ { "id": "40907", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40907" } ] }, { "id": "40959", "name": "", "equation": "2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MGH2-1" ], "evidence": [ { "id": "40959", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40959" } ] }, { "id": "41320", "name": "", "equation": "1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O = 2-acetyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MGH2-1" ], "evidence": [ { "id": "41320", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41320" } ] }, { "id": "41352", "name": "", "equation": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine = a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MGH2-1" ], "evidence": [ { "id": "41352", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41352" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LV96", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] } ] }, { "uniprot_ac": "A0A3Q1M5Z8", "gene_name": "LYPLA1", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0A3Q1M5Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5Z8" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0A3Q1M5Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5Z8" } ] } ] }, { "uniprot_ac": "A0AAA9RYE9", "gene_name": "PNPLA8", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9RYE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE9" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0AAA9RYE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE9" } ] } ] }, { "uniprot_ac": "A0AAA9S0E0", "gene_name": "LYPLA2", "activity": [ { "ec_number": "3.1.2.22", "activity": "S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+).", "evidence": [ { "id": "A0AAA9S0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E0" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "A0AAA9S0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0E0" } ] } ] }, { "uniprot_ac": "A0AAA9T0P5", "gene_name": "PNPLA6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9T0P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0P5" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0AAA9T0P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0P5" } ] } ] }, { "uniprot_ac": "A0AAF6YQE1", "gene_name": "ASRGL1", "activity": [ { "ec_number": "3.4.19.5", "activity": "Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide.", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ] }, { "ec_number": "3.5.1.1", "activity": "L-asparagine + H2O = L-aspartate + NH4(+).", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ] }, { "ec_number": "3.4.19.5", "activity": "", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "A0AAF6YQE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YQE1" } ] } ] }, { "uniprot_ac": "A0AAF7ABT5", "gene_name": "PAFAH1B3", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "A0AAF7ABT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "A0AAF7ABT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF7ABT5" } ] } ] }, { "uniprot_ac": "A4IFJ5", "gene_name": "PLA2G4A", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A4IFJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFJ5" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A4IFJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFJ5" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A4IFJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFJ5" } ] } ] }, { "uniprot_ac": "E1BB89", "gene_name": "PLA2G6", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] } ] }, { "uniprot_ac": "E1BC49", "gene_name": "PLA2G4B", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BC49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC49" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1BC49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC49" } ] } ] }, { "uniprot_ac": "F1MFC1", "gene_name": "PLA2G4E", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1MFC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFC1" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "F1MFC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFC1" } ] } ] }, { "uniprot_ac": "F1MG30", "gene_name": "PLA2G4D", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1MG30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG30" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "F1MG30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG30" } ] } ] }, { "uniprot_ac": "F1MGH2", "gene_name": "ASPG", "activity": [ { "ec_number": "3.5.1.1", "activity": "L-asparagine + H2O = L-aspartate + NH4(+).", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGH2" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "F1MGH2", "database": "UniProtKB", "url": 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"o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGR3-1", "uniprot_ac": "F1MGR3", "uniprot_id": "F1MGR3_BOVIN", "mass": { "chemical_mass": 170031.0, "monoisotopic_mass": 170031.0 }, "refseq": { "ac": "XP_002694095", "name": "arginine-glutamic acid dipeptide repeats protein isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694095" }, "gene_names": [ { "name": "RERE", "type": "recommended", "evidence": [ { "id": "F1MGR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGR3" } ] }, { "name": "RERE", "type": "synonym", "evidence": [ { "id": "XP_002694095", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694095" } ] } ], "protein_names": [ { "name": "Arginine-glutamic acid dipeptide repeats protein", "type": "recommended", "evidence": [ { "id": "F1MGR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGR3/entry#names_and_taxonomy" } ] }, { "name": "arginine-glutamic acid dipeptide repeats protein isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002694095", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694095" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MGR3", "url": "https://www.uniprot.org/uniprotkb/F1MGR3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RERE", "url": "https://www.uniprot.org/uniprotkb/F1MGR3", "locus": { "chromosome": "16", "start_pos": 45029329, "end_pos": 44616328, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018272", "url": "https://www.ensembl.org/id/ENSBTAG00000018272" } ] } } ], "crossref": [ { "id": "ENSBTAG00000018272", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018272", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00202", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00202", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04709", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04709", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11661", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11661", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535394", "url": "https://www.ncbi.nlm.nih.gov/gene/535394", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000679", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000679", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000949", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000949", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001025", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001025", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002951", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002951", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535394", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535394", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M1Q8", "url": "https://www.orthodb.org/?gene=A0A3Q1M1Q8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MNM1", "url": "https://www.orthodb.org/?gene=A0A3Q1MNM1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MWT5", "url": "https://www.orthodb.org/?gene=A0A3Q1MWT5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MGR3", "url": "https://www.orthodb.org/?gene=F1MGR3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13859", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13859", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13859:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13859:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00249", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00249", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00320", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00320", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01426", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01426", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01448", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01448", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03154", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03154", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002694095", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694095", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1Q8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Q8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M1Q8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Q8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNM1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNM1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWT5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MWT5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ56", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGR3", "url": "https://www.uniprot.org/uniprotkb/F1MGR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGR3-1", "url": "https://www.uniprot.org/uniprotkb/F1MGR3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTADKDKDKDKEKDRDRDRDREREKRDKVRESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATTEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKSWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRASPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEATSPLKSTKRQREKGTSDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQTTQPSALQAPGGATPAPSSALPGTAQLPTQGPTPAPAGPSQGSPSASQPPTQPQAPSAAAPHAHIQQAPALHPQRLASPHPPLQPLTGPAGQTTGPPHTQPPLHSQGPPGPHGLQAGSLLQHPGPPQPFGLPPQVSQAAAHPHTSLQPPAPQSALQPQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPVLTQSQGLPPAATSHPATGLHQVPPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGSGPSAQPPCSAAVSSGGSVPGGATCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDPQLGGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYVPLNPTDPLLAYHMPGLYNVDPTIRERELREREIRERELRERELRERMKPGFEVKPPELDPLHPAANPMEHFARHGALTIPPAAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQL", "length": 1545, "header": "tr|F1MGR3-1|F1MGR3_BOVIN Isoform 1 of Arginine-glutamic acid dipeptide repeats protein OS=Bos taurus OX=9913 GN=RERE PE=4 SV=4 CANONICAL=F1MGR3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M1Q8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Q8/entry", "sequence": { "sequence": "MTADKDKDKDKEKDRDRDRDREREKRDKVRESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATTEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKSWTEDEVGELITFYYYWKKTPEAASSRAHRRHRRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRASPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEATSPLKSTKRQREKGTSDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQTTQPSALQAPGGATPAPSSALPGTAQLPTQGPTPAPAGPSQGSPSASQPPTQPQAPSAAAPHAHIQQAPALHPQRLASPHPPLQPLTGPAGQTTGPPHTQPPLHSQGPPGPHGLQAGSLLQHPGPPQPFGLPPQVSQAAAHPHTSLQPPAPQSALQPQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPVLTQSQGLPPAATSHPATGLHQVPPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGSGPSAQPPCSAAVSSGGSVPGGATCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDPQLGGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYVPLNPTDPLLAYHMPGLYNVDPTIRERELREREIRERELRERELRERMKPGFEVKPPELDPLHPAANPMEHFARHGALTIPPAAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQL", "length": 1518, "header": "tr|A0A3Q1M1Q8-1|F1MGR3_BOVIN Computationally mapped isoform of Arginine-glutamic acid dipeptide repeats protein OS=Bos taurus OX=9913 GN=RERE PE=4 SV=2 CANONICAL=F1MGR3-1" }, "locus": { "chromosome": "16", "start_pos": 45028325, "end_pos": 44771878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075404.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075404.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061996.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061996.2" } ] } }, { "isoform_ac": "A0A3Q1MNM1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNM1/entry", "sequence": { "sequence": "MTADKDKDKDKEKDRDRDRDREREKRDKVRESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATTEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKSWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRASPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEATSPLKSTKRQREKGTSDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQTTQPSALQAPGGATPAPSSALPGTAQLPTQGPTPAPAGPSQGSPSASQPPTQPQAPSAAAPHAHIQQAPALHPQRLASPHPPLQPLTGPAGQTTGPPHTQPPLHSQGPPGPHGLQAGSLLQHPGPPQPFGLPPQVSQAAAHPHTSLQPPAPQSALQPQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPVLTQSQGLPPAATSHPATGLHQVPPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGSGPSAQPPCSAAVSSGGSVPGGATCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDPQLGGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYVPLNPTDPLLAYHMPGLYNVDPTIRERELREREIRERELRERELRERMKPGFEVKPPELDPLHPAANPMEHFARHGALTIPPAAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQL", "length": 1503, "header": "tr|A0A3Q1MNM1-1|F1MGR3_BOVIN Computationally mapped isoform of Arginine-glutamic acid dipeptide repeats protein OS=Bos taurus OX=9913 GN=RERE PE=4 SV=2 CANONICAL=F1MGR3-1" }, "locus": { "chromosome": "16", "start_pos": 45028325, "end_pos": 44771878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071089.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071089.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073518.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073518.2" } ] } }, { "isoform_ac": "A0A3Q1MWT5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWT5/entry", "sequence": { "sequence": "MTADKDKDKDKEKDRDRDRDREREKRDKVRESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATTEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKSWTEDEVK", "length": 402, "header": "tr|A0A3Q1MWT5-1|F1MGR3_BOVIN Computationally mapped isoform of Arginine-glutamic acid dipeptide repeats protein OS=Bos taurus OX=9913 GN=RERE PE=4 SV=2 CANONICAL=F1MGR3-1" }, "locus": { "chromosome": "16", "start_pos": 44961814, "end_pos": 44771878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079389.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079389.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060040.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060040.2" } ] } }, { "isoform_ac": "A0AAA9SJ56-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ56/entry", "sequence": { "sequence": "MTADKDKDKDKEKDRDRDRDREREKRDKVRESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATTEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKSWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTSTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQL", "length": 584, "header": "tr|A0AAA9SJ56-1|F1MGR3_BOVIN Computationally mapped isoform of Arginine-glutamic acid dipeptide repeats protein OS=Bos taurus OX=9913 GN=RERE PE=4 SV=1 CANONICAL=F1MGR3-1" }, "locus": { "chromosome": "16", "start_pos": 45028325, "end_pos": 44771878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098451.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098451.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083839.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083839.1" } ] } }, { "isoform_ac": "F1MGR3-1", "url": "https://www.uniprot.org/uniprotkb/F1MGR3/entry", "sequence": { "sequence": "MTADKDKDKDKEKDRDRDRDREREKRDKVRESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATTEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKSWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKKTPEAASSRAHRRHRRQAVFRRIKTRTASTPVNTPSRPPSSEFLDLSSASEDDFDSEDSEQELKGYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRASPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEATSPLKSTKRQREKGTSDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQTTQPSALQAPGGATPAPSSALPGTAQLPTQGPTPAPAGPSQGSPSASQPPTQPQAPSAAAPHAHIQQAPALHPQRLASPHPPLQPLTGPAGQTTGPPHTQPPLHSQGPPGPHGLQAGSLLQHPGPPQPFGLPPQVSQAAAHPHTSLQPPAPQSALQPQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPVLTQSQGLPPAATSHPATGLHQVPPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGSGPSAQPPCSAAVSSGGSVPGGATCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDPQLGGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYVPLNPTDPLLAYHMPGLYNVDPTIRERELREREIRERELRERELRERMKPGFEVKPPELDPLHPAANPMEHFARHGALTIPPAAGPHPFASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQL", "length": 1545, "header": "tr|F1MGR3-1|F1MGR3_BOVIN Isoform 1 of Arginine-glutamic acid dipeptide repeats protein OS=Bos taurus OX=9913 GN=RERE PE=4 SV=4 CANONICAL=F1MGR3-1" }, "locus": { "chromosome": "16", "start_pos": 45028325, "end_pos": 44771878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024320.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024320.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024320.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024320.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1027, "start_aa": "Thr", "end_pos": 1027, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1027", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 144, "start_aa": "Thr", "end_pos": 144, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr144", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 745, "start_aa": "Thr", "end_pos": 745, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr745", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 764, "start_aa": "Thr", "end_pos": 764, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr764", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:535394", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535394", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "F1MGR3", "url": "https://www.uniprot.org/uniprotkb/F1MGR3" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "F1MGR3", "url": "https://www.uniprot.org/uniprotkb/F1MGR3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MGR3", "url": "https://www.uniprot.org/uniprotkb/F1MGR3" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": 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"GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "F1MGR3", "url": "https://www.uniprot.org/uniprotkb/F1MGR3" } ], "pmid": "" }, { "name": "histone deacetylase complex", "id": "GO:0000118", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000118", "evidence": [ { "database": "UniProtKB", "id": "F1MGR3", "url": "https://www.uniprot.org/uniprotkb/F1MGR3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MGR3", "url": "https://www.uniprot.org/uniprotkb/F1MGR3" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1MGR3", "url": "https://www.uniprot.org/uniprotkb/F1MGR3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1400, "end_pos": 1402, "annotation": "n_glycosylation_sequon" }, { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 280, "end_pos": 282, "annotation": "n_glycosylation_sequon" }, { "start_pos": 622, "end_pos": 624, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 708, "end_pos": 710, "annotation": "n_glycosylation_sequon" }, { "start_pos": 721, "end_pos": 723, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MGR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGR3" }, { "id": "PS51038", 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"database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524352", "url": "https://www.ncbi.nlm.nih.gov/gene/524352", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035789", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035789", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046376", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046376", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524352", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524352", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DILKCMA", "url": "https://omabrowser.org/oma/group/DILKCMA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3G8", "url": "https://www.orthodb.org/?gene=A0A3Q1M3G8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M662", "url": "https://www.orthodb.org/?gene=A0A3Q1M662", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M694", "url": "https://www.orthodb.org/?gene=A0A3Q1M694", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NFU0", "url": "https://www.orthodb.org/?gene=A0A3Q1NFU0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MBM9", "url": "https://www.orthodb.org/?gene=F1MBM9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46026", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46026", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46026:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46026:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16523", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16523", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16614", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16614", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-182971", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3928664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-416482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013406", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013406", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013420", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013420", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013424", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013424", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024855645", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855645", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3G8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3G8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3G8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3G8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M662", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M662", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M662-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M662-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M694", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M694", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M694-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M694-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NFU0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFU0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NFU0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFU0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NJA9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NJA9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBM9", "url": "https://www.uniprot.org/uniprotkb/F1MBM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBM9-1", "url": "https://www.uniprot.org/uniprotkb/F1MBM9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSEGECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGPQPAHGRTSQLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFAKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREVKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANTSHLMGNLEEICSFQQMLVQSLEECTKMPEAQQRVGGCFLSLMPQMKTLYLTYCANHPSAVSVLTEHSEELGEFMELKGASSPGILVLTTGLSKPFMRLDKYPALLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEAIRSWEGEDIKTLGSVLYMSQVLIQCAGSEEKNERYLLLFPNILLMLSASSRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCSNQQDLHEWVDRLQKQTKAASAGNPSSKPHSVPSHTLPSHSITPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFALRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQSSLDSLGRRSSLSRVEPSDFSEDSDYDSIWTAHSYRMGSTSRSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL", "length": 862, "header": "tr|F1MBM9-1|F1MBM9_BOVIN Isoform 1 of Rho guanine nucleotide exchange factor 7 OS=Bos taurus OX=9913 GN=ARHGEF7 PE=4 SV=3 CANONICAL=F1MBM9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3G8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3G8/entry", "sequence": { "sequence": "MGGRPGAVSLVVYPEPRSEGECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGPQPAHGRTSQLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFAKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREVKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANTSHLMGNLEEICSFQQMLVQSLEECTKMPEAQQRVGGCFLSLMPQMKTLYLTYCANHPSAVSVLTEHSEELGEFMELKGASSPGILVLTTGLSKPFMRLDKYPALLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEAIRSWEGEDIKTLGSVLYMSQVLIQCAGSEEKNERYLLLFPNILLMLSASSRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCSNQQDLHEWVDRLQKQTKAASAGNPSSKPHSVPSHTLPSHSITPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFALRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL", "length": 759, "header": "tr|A0A3Q1M3G8-1|F1MBM9_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 7 OS=Bos taurus OX=9913 GN=ARHGEF7 PE=4 SV=3 CANONICAL=F1MBM9-1" }, "locus": { "chromosome": "12", "start_pos": 85535515, "end_pos": 85445546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080999.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080999.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068046.3", "url": "https://www.ensembl.org/id/ENSBTAP00000068046.3" } ] } }, { "isoform_ac": "A0A3Q1M662-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M662/entry", "sequence": { "sequence": "MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKTFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGPQPAHGRTSQLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFAKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREVKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANTSHLMGNLEEICSFQQMLVQSLEECTKMPEAQQRVGGCFLSLMPQMKTLYLTYCANHPSAVSVLTEHSEELGEFMELKGASSPGILVLTTGLSKPFMRLDKYPALLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEAIRSWEGEDIKTLGSVLYMSQVLIQCAGSEEKNERYLLLFPNILLMLSASSRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCSNQQDLHEWVDRLQKQTKAASAGNPSSKPHSVPSHTLPSHSITPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFALRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQSSLDSLGRRSSLSRVEPSDFSEDSDYDSIWTAHSYRMGSTSRKSCCSYISHQN", "length": 753, "header": "tr|A0A3Q1M662-1|F1MBM9_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 7 OS=Bos taurus OX=9913 GN=ARHGEF7 PE=4 SV=1 CANONICAL=F1MBM9-1" }, "locus": { "chromosome": "12", "start_pos": 85526847, "end_pos": 85435272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079985.1", "url": "https://www.ensembl.org/id/ENSBTAT00000079985.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065443.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065443.1" } ] } }, { "isoform_ac": "A0A3Q1M694-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M694/entry", "sequence": { "sequence": "MKTFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGPQPAHGRTSQLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFAKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREVKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANTSHLMGNLEEICSFQQMLVQSLEECTKMPEAQQRVGGCFLSLMPQMKTLYLTYCANHPSAVSVLTEHSEELGEFMELKGASSPGILVLTTGLSKPFMRLDKYPALLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEAIRSWEGEDIKTLGSVLYMSQVLIQCAGSEEKNERYLLLFPNILLMLSASSRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCSNQQDLHEWVDRLQKQTKAASAGNPSSKPHSVPSHTLPSHSITPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFALRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL", "length": 721, "header": "tr|A0A3Q1M694-1|F1MBM9_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 7 OS=Bos taurus OX=9913 GN=ARHGEF7 PE=4 SV=2 CANONICAL=F1MBM9-1" }, "locus": { "chromosome": "12", "start_pos": 85535515, "end_pos": 85474394, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071925.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071925.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065485.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065485.2" } ] } }, { "isoform_ac": "A0A3Q1NFU0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFU0/entry", "sequence": { "sequence": "MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSEGECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGPQPAHGRTSQLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFAKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREVKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANTSHLMGNLEEICSFQQMLVQSLEECTKMPEAQQRVGGCFLSLMPQMKTLYLTYCANHPSAVSVLTEHSEELGEFMELKGASSPGILVLTTGLSKPFMRLDKYPALLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEAIRSWEGEDIKTLGSVLYMSQVLIQCAGSEEKNERYLLLFPNILLMLSASSRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCSNQQDLHEWVDRLQKQTKAASAGNPSSKPHSVPSHTLPSHSITPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFALRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQSSLDSLGRRSSLSRVEPSDFSEDSDYDSIWTAHSYRMGSTSRKSCCSYISHQN", "length": 782, "header": "tr|A0A3Q1NFU0-1|F1MBM9_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 7 OS=Bos taurus OX=9913 GN=ARHGEF7 PE=4 SV=2 CANONICAL=F1MBM9-1" }, "locus": { "chromosome": "12", "start_pos": 85526847, "end_pos": 85435272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071631.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071631.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070580.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070580.2" } ] } }, { "isoform_ac": "A0ABI0NJA9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJA9/entry", "sequence": { "sequence": "MGGRPGAVSLVVYPEPRSEGECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGPQPAHGRTSQLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFAKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREVKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANTSHLMGNLEEICSFQQMLVQSLEECTKMPEAQQRVGGCFLSLMPQMKTLYLTYCANHPSAVSVLTEHSEELGEFMELKGASSPGILVLTTGLSKPFMRLDKYPALLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEAIRSWEGEDIKTLGSVLYMSQVLIQCAGSEEKNERYLLLFPNILLMLSASSRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCSNQQDLHEWVDRLQKQTKAASAGNPSSKPHSVPSHTLPSHSITPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFALRKSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL", "length": 729, "header": "tr|A0ABI0NJA9-1|A0ABI0NJA9_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 7 OS=Bos taurus OX=9913 GN=ARHGEF7 PE=4 SV=1 CANONICAL=F1MBM9-1" }, "locus": { "chromosome": "12", "start_pos": 85535515, "end_pos": 85445546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144860.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144860.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104491.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104491.1" } ] } }, { "isoform_ac": "F1MBM9-1", "url": "https://www.uniprot.org/uniprotkb/F1MBM9/entry", "sequence": { "sequence": "MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSEGECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGPQPAHGRTSQLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFAKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREVKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANTSHLMGNLEEICSFQQMLVQSLEECTKMPEAQQRVGGCFLSLMPQMKTLYLTYCANHPSAVSVLTEHSEELGEFMELKGASSPGILVLTTGLSKPFMRLDKYPALLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEAIRSWEGEDIKTLGSVLYMSQVLIQCAGSEEKNERYLLLFPNILLMLSASSRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCSNQQDLHEWVDRLQKQTKAASAGNPSSKPHSVPSHTLPSHSITPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFALRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQSSLDSLGRRSSLSRVEPSDFSEDSDYDSIWTAHSYRMGSTSRSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL", "length": 862, "header": "tr|F1MBM9-1|F1MBM9_BOVIN Isoform 1 of Rho guanine nucleotide exchange factor 7 OS=Bos taurus OX=9913 GN=ARHGEF7 PE=4 SV=3 CANONICAL=F1MBM9-1" }, "locus": { "chromosome": "12", "start_pos": 85535515, "end_pos": 85435272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027619.8", "url": "https://www.ensembl.org/id/ENSBTAT00000027619.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027619.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027619.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524352", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524352", "resource": "KEGG Pathway" }, { "id": "R-BTA-182971", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-182971", "resource": "Reactome", "description": "EGFR downregulation" }, { "id": "R-BTA-3928664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3928664", "resource": "Reactome", "description": "Ephrin signaling" }, { "id": "R-BTA-416482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013406", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013406", "resource": "Reactome", "description": "RHOQ GTPase cycle" }, { "id": "R-BTA-9013420", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013420", "resource": "Reactome", "description": "RHOU GTPase cycle" }, { "id": "R-BTA-9013424", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013424", "resource": "Reactome", "description": "RHOV GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287B6C4-1", "protein_name": "Rho guanine nucleotide exchange factor 7", "gene_name": "ARHGEF7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSEGECLSNIREFLRGCGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQPSHARTSKLFQGQYRSLDMSDNSSSQLVVRAKFNFQQTNEDELSFARGDVIHVTRVEEGGWWEGTLDGRTGWFPSNYVREVKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSAYLRPLQTSEKLSSANMSYLMGNLEEICSFQQMLVQSLEECTKVPEAQQRVGGCFLSLMPQMKTLYLAYCANHPSAVSVLTQHSEELGEFMEMKGASSPGVLVLTTGLSKPFMRLDKYPALLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEAIRSWEGDDIKTLGHVIHMSQVLIQCAGSEEKNERYLLLFPNILLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCSNQQDLHEWVDHLQKQTKVTSAGNPTIKPHSVPSHTLPSHSITPSSKHADSKPAPLTPTYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFALRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEDEQRARRDLEKLLRKVLKSMNDPAWDETNL", "length": 803 }, "evidence": [ { "id": "F1MBM9", "url": "https://omabrowser.org/oma/group/F1MBM9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3Q2TZR1-1", "protein_name": "Rho guanine nucleotide exchange factor 7", "gene_name": "ARHGEF7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTSAEQTVTWLIALGVLESPKKSIADPEGFLQSSLKDGVVLCRLLERLLPGSIEKVYPEPRTEGECLSNIREFLRGCGASLRLETFDANDLYQGQNFSKVLSSLVALNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHSRTSKLFQGQYRSLDMTDNSNHQLVVRAKFNFQQTNEDELSFSKGDIIHVTRVEEGGWWEGTLNGKTGWFPSNYVREIKSNEKPVSPKSGTLKSPPKGFDTSAINKSYYNVVLQNILETENEYSKELQTMLSNYLRPLQASEKLSSTNTSYLMGNLEEISSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMSQMKNLYLAYCANHPSAVNVLTEHSEELGEFMEVKGANSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRPDIQKSMTAFKNLSAQCQEVRKRKELELQILTEAIRCWEGEDIKTLGNVIYMSQVMIQCAGSEEKNERYLLLFPNILLMLSASPRMSGFIYQGKLPMTGMTITKLEDTENHKNAFEISGTMIERILVSCNNQQDLHEWVDHLQKQTKVTAVGNPTIKPHSVPSHTLPSHPVTPSSKHSDSKQIPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFALRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQSSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPSWDETNL", "length": 862 }, "evidence": [ { "id": "F1MBM9", "url": "https://omabrowser.org/oma/group/F1MBM9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8M2BEZ3-1", "protein_name": "Rho guanine nucleotide exchange factor 7a isoform X5", "gene_name": "arhgef7a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNPAEQTVTWLITLGVLESPKKTISDPDGFLQASLKDGVVLCRLLERLRPGTTDKIIQDPKNDSECLSNITEFLKGCAVFRVEPFEAGDLLQGHNISRVLTTLVALNKVTADIGIGSDSVCTRHSSAHRIKSFESLASQSSLGRSSKLLHNQFRSLDMTDNSNAQLVVKARFNFQQTNEDELTFSKGDLISVTRTEEGGWWEGILNGKTGWFPSNYVKEVKGSDKQVSPKSGNLKSPPKGFDTASISKTYYNLVLQNILETETEYSRELQNLLTSYLRPLQMTERLSPADVSVILGNLEEISTFQQTLVQSLEDLTKLPELQQKVGGFFLNLMPQMRSLNVSYCSNHPSTVNVLTVHSEELGEFMEARGASVPGILTLTSGLSKPFMRLDRYPTLLKELERHMEEGHPDRTEIQKCMTAFKNLSAQCQEVRKRKELELQILAETIRLWEGEDIKTLGSVLYMSQAMVQNHGCEEKNERYLLLFPHVLLILSASPRMSGFIYQGKLPLSGMTVTPLEDCESHKDAFELSGSMFERLQVICYNKQDLHDWLEHLNRQTKHTTMAAPSMKPLTVPCHTLPSHPLTPSRHGESRGLTVAPAYHTLPHPSSHGTPHSTMMWGPLEPPKTQKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFALRKSTVALEEDAQILKVIEAYCTSAKTRQTLNSRQWKDGSPALIVPGDEKFSVDELKSNGQTLLEEKSLVDVVYALRDEVQELKQDYKKMKKSLEEEQRARKDLERIVKKMLKNMNDPSWDETNL", "length": 802 }, "evidence": [ { "id": "F1MBM9", "url": "https://omabrowser.org/oma/group/F1MBM9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A9J7KEX7-1", "protein_name": "Rho guanine nucleotide exchange factor 7 isoform X3", "gene_name": "Arhgef7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTDNSNSQLVVRAKFNFQQTNEDELSFTKGDVIHVTRVEEGGWWEGTHSGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSMLSTYLRPLQTSEKLSSANTSYLLGNLEEISSFQQVLVQTLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVGVLTEHSEDLGEFMESKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAHCQEVRKRKELELQILTEPIRSWEGDDIKSLGSVTYMSQVTIQCAGSEEKNERYLLLFPSLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLHEWVDHLQKQTKVTSVTNPTIKPHSVPSHTLPSHPITPSSKHGDSKPVALTPAYHTLPHPSHHGTPHTTISWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQSSLDSLGRRSSLSRLEPSDLSEDSEYDSIWTAHSYRMGSASRSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL", "length": 705 }, "evidence": [ { "id": "F1MBM9", "url": "https://omabrowser.org/oma/group/F1MBM9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O55043-1", "protein_name": "Rho guanine nucleotide exchange factor 7", "gene_name": "Arhgef7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTDNANSQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLWPLQTSEKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLHEWVEHLQRQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGTPHTTISWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSRSPKTMKKLLPKRKPERKPSDEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSSSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL", "length": 646 }, "evidence": [ { "id": "F1MBM9", "url": "https://omabrowser.org/oma/group/F1MBM9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9ES28-1", "protein_name": "Rho guanine nucleotide exchange factor 7", "gene_name": "Arhgef7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSAEQTVTWLITLGVLESPKKTISDPEVFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRNESECLSNIREFLRACGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSSHSRTSKLLQSQYRSLDMTDNTNSQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLRPLQTSDKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCTSQQDLHEWVEHLQKQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGTPHTTISWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQSSLDSLGRRSSLSRLEPSDLSEDSEYDSIWTAHSYRMGSASRSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL", "length": 862 }, "evidence": [ { "id": "F1MBM9", "url": "https://omabrowser.org/oma/group/F1MBM9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "F1MBM9", "url": "https://www.uniprot.org/uniprotkb/F1MBM9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MBM9", "url": "https://www.uniprot.org/uniprotkb/F1MBM9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MBM9", "url": "https://www.uniprot.org/uniprotkb/F1MBM9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MBM9", "url": "https://www.uniprot.org/uniprotkb/F1MBM9" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "F1MBM9", "url": "https://www.uniprot.org/uniprotkb/F1MBM9" } ], "pmid": "" }, { "name": "storage vacuole", "id": "GO:0000322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000322", "evidence": [ { "database": "UniProtKB", "id": "F1MBM9", "url": "https://www.uniprot.org/uniprotkb/F1MBM9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "F1MBM9", "url": "https://www.uniprot.org/uniprotkb/F1MBM9" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "F1MBM9", "url": "https://www.uniprot.org/uniprotkb/F1MBM9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lamellipodium assembly", "id": "GO:0030032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030032", "evidence": [ { "database": "UniProtKB", "id": "F1MBM9", "url": "https://www.uniprot.org/uniprotkb/F1MBM9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" }, { "start_pos": 290, "end_pos": 292, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 710, "end_pos": 712, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MBM9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 862, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MBM9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MBM9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM9" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 112, "start_aa": "Met", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM9" }, { "id": "PS50010", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50010" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DH", "eco_id": "ECO_0000259", "start_pos": 250, "end_pos": 430, "start_aa": "Tyr", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM9" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 452, "end_pos": 557, "start_aa": "Asp", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MBM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM9" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 163, "end_pos": 222, "start_aa": "Asn", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 247, "end_pos": 249 }, { "start_pos": 290, "end_pos": 292 }, { "start_pos": 422, "end_pos": 424 }, { "start_pos": 710, "end_pos": 712 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MHK9-1", "uniprot_ac": "F1MHK9", "uniprot_id": "F1MHK9_BOVIN", "mass": { "chemical_mass": 188235.0, "monoisotopic_mass": 188235.0 }, "refseq": {}, "gene_names": [ { "name": "ABCA14", "type": "recommended", "evidence": [ { "id": "F1MHK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHK9" } ] } ], "protein_names": [ { "name": "ATP binding cassette subfamily A member 14", "type": "synonym", "evidence": [ { "id": "F1MHK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHK9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MHK9", "url": "https://www.uniprot.org/uniprotkb/F1MHK9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABCA14", "url": "https://www.uniprot.org/uniprotkb/F1MHK9", "locus": { "chromosome": "25", "start_pos": 19374100, "end_pos": 19138231, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006717", "url": "https://www.ensembl.org/id/ENSBTAG00000006717" } ] } } ], "crossref": [ { "id": "ENSBTAG00000006717", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006717", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03263", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03263", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056264", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056264", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR19229", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19229:SF139", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19229:SF139", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12698", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12698", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23321", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23321", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26955", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26955", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "39051", "url": "https://www.rhea-db.org/rhea/39051", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M450", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M450", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M450-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M450-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHK9", "url": "https://www.uniprot.org/uniprotkb/F1MHK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHK9-1", "url": "https://www.uniprot.org/uniprotkb/F1MHK9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "CKILIIPSFHFSLWVFFLIKRKMGSLIVEISMTVLFCSLILLLRKHSKREFTQATLFQSLPLNKLPAFLTNKKKDYELVYVPSGSDAAKNITEKVKDDLNANLTVRGFPSEEDFEKYIKYENQSVLVLAAIIFDHEFKNSNDRLPLKVKYRLRFHSIKNTPWFTELLFPVNPSRGPRNPSSTEGGSPDYYKGGFLLVQHALDKAIIVYHNGRAAEMLFANVNIFVSRFPYPTYYKDNFFLSFLSLFPLAVLLIFSLTELTLIRTIVMEKETRLKEYQFMIGLSNGMLWASYFVTFLLMFLIIVCILCVVLFVKIVPVVVLQNSDPSLIFVFFLCFVVATITFGFLITTFFDKTSLAVSIGGFLFFLTFFPFVVVITMYGMLSRTGKLASCLLSNIAVALGITTISKLEIKEYGAKWNNFLSRVSPDDELTLAHIMGMLLFDAFLYGLLAWYIDAVFPGKYGVPKPWYFFMQKGYWLGKATSIRKKEDMPVTNTVQNAYFEEEPVGLIAGIRIQHLYKEFTLQNMTVLAVQDLSLNLYEGQITVLLGHNGAGKTTTLSILTGLYRPTSGKVYISGYDISKDMVQVRKSLGLCPQDDILFHHLTVSEHLYFYCVIKGVPPEIQSKEINKMLISFGLIEKHDALAKSLSGGMKRKLSIIIALIGGSKVVILDEPTSGMDPVSRRFTWDVLQKHKENRTVLLTTHHMDEADVLGDRIAIMAKGTLQCCGSTIFLKKVYGVGYHLIIVKDHHCDVKEISELIKYHIPEARLENNVAAELSFVLPKEYTDRFKALFTEMEDRQEELGIASFGISITTMEEVFIRVSQSNNQILQTLKNEDESEDTNQNMNVPRNFERSYAVMPSSVLLSCQWALYSQQFFAMFMKRAMFSWRNWNLILLQILALLGIFYFLMSDVELSIGEEDLDREMDLEQYGQTIVPFSISGNSEFTTNFVKNLEILLKAKKQKLHEVKGDLKTYLVDSQKCIYSCIIAFSIEVNGNENTVNFWFNDEAYHSSPLSLAVLDNVIFMSLSGPDASITVVNKPQPVRSASRTQIALNLYFGVSILVSGFCLLTVNERVTKAKHIQFLSGVYALNFWLSALLWDFLIFFISCCLLLVVFTFSDLKILVTGYRLLDTLFIFMVFGWAVIPFMYLISFLFSSHTSAYAKLVIFNYCAGIFGILLSWDSSFHINHANVIIFLNTGEEAASKSLLLNAMMVLPIHNFGMSISRHYDIHKSIFYLLLSSVTERSIYTLEYDAVGRYLLAMAVTGLLFLLLIFLLETTLWKVKTFVFRYILFGIFKKSNKVMSKELSGESEDEDVQNERNRILDNPQESLNSIVLIKELIKVYFSKPVVLAVRNISVAIQKQECFGLLGLNGAGKTTTFEILTGEEVASSGDVFVERLSITKNILKVRSKIGYCPQFDALLDYMTAREIMIMYARLWGIPETKINNYVKKSMEALNLESYADKYIYTYSGGNKRRLSTAIALMGKPSVIFLDEPSTGMDPVARRLLWNAVTRTRESGKAIIITSHSMEECDALCTKLAIMVKGKFVCLGSPQHLKNKFGNVYILKVKINIDENKDKLEHFKTFVETAFPGSELKDENRGIINYYVPSKNNSWGKMFGILEKAKEEFNLEDYSISQITLEQVFLTFAGSQNPEVEKKES", "length": 1655, "header": "tr|F1MHK9-1|F1MHK9_BOVIN Isoform 1 of ATP binding cassette subfamily A member 14 OS=Bos taurus OX=9913 GN=ABCA14 PE=4 SV=4 CANONICAL=F1MHK9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M450-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M450/entry", "sequence": { "sequence": "CKILIIPSFHFSLWVFFLIKRKMGSLIVEISMTVLFCSLILLLRKHSKREFTQATLFQSLPLNKLPAFLTNKKKDYELVYVPSGSDAAKNITEKVKDDLNANLTVRGFPSEEDFEKYIKYENQSVLVLAAIIFDHEFKNSNDRLPLKVKYRLRFHSIKNTPWFTELLFPVNPSRGPRNPSSTEGGSPDYYKGGFLLVQHALDKAIIVYHNGRAAEMLFANVNIFVSRFPYPTYYKDNFFLSFLSLFPLAVLLIFSLTELTLIRTIVMEKETRLKEYQFMIGLSNGMLWASYFVTFLLMFLIIVCILCVVLFVKIVPVVVLQNSDPSLIFVFFLCFVVATITFGFLITTFFDKTSLAVSIGGFLFFLTFFPFVVVITMYGMLSRTGKLASCLLSNIAVALGITTISKLEIKEYGAKWNNFLSRVSPDDELTLAHIMGMLLFDAFLYGLLAWYIDAVFPGKYGVPKPWYFFMQKGYWLGKATSIRKKEDMPVTNTVQNAYFEEEPVGLIAGIRIQHLYKEFTLQNMTVLAVQDLSLNLYEGQITVLLGHNGAGKTTTLSILTGLYRPTSGKVYISGYDISKDMVQVRKSLGLCPQDDILFHHLTVSEHLYFYCVIKGVPPEIQSKEINKMLISFGLIEKHDALAKSLSGGMKRKLSIIIALIGGSKVVILDEPTSGMDPVSRRFTWDVLQKHKENRTVLLTTHHMDEADVLGDRIAIMAKGTLQCCGSTIFLKKVYGVGYHLIIVKDHHCDVKEISELIKYHIPEARLENNVAAELSFVLPKEYTDRFKALFTEMEDRQEELGIASFGISITTMEEVFIRVSQSNNQILQTLKNEDESEDTNQNMNVPRNFERSYAVMPSSVLLSCQWALYSQQFFAMFMKRAMFSWRNWNLILLQILALLGIFYFLMSDVELSIGEEDLDREMDLEQYGQTIVPFSISGNSEFTTNFVKNLEILLKAKKQKLHEVKGNQKCIYSCIIAFSIEVNGNENTVNFWFNDEAYHSSPLSLAVLDNVIFMSLSGPDASITVVNKPQPVRSASRTQIALNLYFGVSILVSGFCLLTVNERVTKAKHIQFLSGVYALNFWLSALLWDFLIFFISCCLLLVVFTFSDLKILVTGYRLLDTLFIFMVFGWAVIPFMYLISFLFSSHTSAYAKLVIFNYCAGIFEIIVNNIPNLIKDMNLQTQEIHLLLNAMMVLPIHNFGMSISRHYDIQHTKFSIFYLLLSSVTERSIYTLEYDAVGRYLLAMAVTGLLFLLLIFLLETTLWKVKTFVFRYILFGIFKKSNKDRVSKELSGESEDEDVQNERNRILDNPQESLNSIVLIKELIKVYFSKPVVLAVRNISVAIQKQECFGLLGLNGAGKTTTFEILTGEEVASSGDVFVERLSITKNILKVRSKIGYCPQFDALLDYMTAREIMIMYARLWGIPETKINNYVKKSMEALNLESYADKYIYTYSGGNKRRLSTAIALMGKPSVIFLDEPSTGMDPVARRLLWNAVTRTRESGKAIIITSHSMEECDALCTKLAIMVKGKFVCLGSPQHLKNKFGNVYILKQYAKLRIYPIFSFSGSELKDENRGIINYYVPSKNNSWGKMFGILEKAKEEFNLEDYSISQITLEQVFLTFAGSQNPEVEKKES", "length": 1632, "header": "tr|A0A3Q1M450-1|F1MHK9_BOVIN Computationally mapped isoform of ATP binding cassette subfamily A member 14 OS=Bos taurus OX=9913 GN=ABCA14 PE=4 SV=2 CANONICAL=F1MHK9-1" }, "locus": { "chromosome": "25", "start_pos": 19374097, "end_pos": 19138231, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070268.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070268.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064565.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064565.2" } ] } }, { "isoform_ac": "F1MHK9-1", "url": "https://www.uniprot.org/uniprotkb/F1MHK9/entry", "sequence": { "sequence": "CKILIIPSFHFSLWVFFLIKRKMGSLIVEISMTVLFCSLILLLRKHSKREFTQATLFQSLPLNKLPAFLTNKKKDYELVYVPSGSDAAKNITEKVKDDLNANLTVRGFPSEEDFEKYIKYENQSVLVLAAIIFDHEFKNSNDRLPLKVKYRLRFHSIKNTPWFTELLFPVNPSRGPRNPSSTEGGSPDYYKGGFLLVQHALDKAIIVYHNGRAAEMLFANVNIFVSRFPYPTYYKDNFFLSFLSLFPLAVLLIFSLTELTLIRTIVMEKETRLKEYQFMIGLSNGMLWASYFVTFLLMFLIIVCILCVVLFVKIVPVVVLQNSDPSLIFVFFLCFVVATITFGFLITTFFDKTSLAVSIGGFLFFLTFFPFVVVITMYGMLSRTGKLASCLLSNIAVALGITTISKLEIKEYGAKWNNFLSRVSPDDELTLAHIMGMLLFDAFLYGLLAWYIDAVFPGKYGVPKPWYFFMQKGYWLGKATSIRKKEDMPVTNTVQNAYFEEEPVGLIAGIRIQHLYKEFTLQNMTVLAVQDLSLNLYEGQITVLLGHNGAGKTTTLSILTGLYRPTSGKVYISGYDISKDMVQVRKSLGLCPQDDILFHHLTVSEHLYFYCVIKGVPPEIQSKEINKMLISFGLIEKHDALAKSLSGGMKRKLSIIIALIGGSKVVILDEPTSGMDPVSRRFTWDVLQKHKENRTVLLTTHHMDEADVLGDRIAIMAKGTLQCCGSTIFLKKVYGVGYHLIIVKDHHCDVKEISELIKYHIPEARLENNVAAELSFVLPKEYTDRFKALFTEMEDRQEELGIASFGISITTMEEVFIRVSQSNNQILQTLKNEDESEDTNQNMNVPRNFERSYAVMPSSVLLSCQWALYSQQFFAMFMKRAMFSWRNWNLILLQILALLGIFYFLMSDVELSIGEEDLDREMDLEQYGQTIVPFSISGNSEFTTNFVKNLEILLKAKKQKLHEVKGDLKTYLVDSQKCIYSCIIAFSIEVNGNENTVNFWFNDEAYHSSPLSLAVLDNVIFMSLSGPDASITVVNKPQPVRSASRTQIALNLYFGVSILVSGFCLLTVNERVTKAKHIQFLSGVYALNFWLSALLWDFLIFFISCCLLLVVFTFSDLKILVTGYRLLDTLFIFMVFGWAVIPFMYLISFLFSSHTSAYAKLVIFNYCAGIFGILLSWDSSFHINHANVIIFLNTGEEAASKSLLLNAMMVLPIHNFGMSISRHYDIHKSIFYLLLSSVTERSIYTLEYDAVGRYLLAMAVTGLLFLLLIFLLETTLWKVKTFVFRYILFGIFKKSNKVMSKELSGESEDEDVQNERNRILDNPQESLNSIVLIKELIKVYFSKPVVLAVRNISVAIQKQECFGLLGLNGAGKTTTFEILTGEEVASSGDVFVERLSITKNILKVRSKIGYCPQFDALLDYMTAREIMIMYARLWGIPETKINNYVKKSMEALNLESYADKYIYTYSGGNKRRLSTAIALMGKPSVIFLDEPSTGMDPVARRLLWNAVTRTRESGKAIIITSHSMEECDALCTKLAIMVKGKFVCLGSPQHLKNKFGNVYILKVKINIDENKDKLEHFKTFVETAFPGSELKDENRGIINYYVPSKNNSWGKMFGILEKAKEEFNLEDYSISQITLEQVFLTFAGSQNPEVEKKES", "length": 1655, "header": "tr|F1MHK9-1|F1MHK9_BOVIN Isoform 1 of ATP binding cassette subfamily A member 14 OS=Bos taurus OX=9913 GN=ABCA14 PE=4 SV=4 CANONICAL=F1MHK9-1" }, "locus": { "chromosome": "25", "start_pos": 19374097, "end_pos": 19138231, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008832.8", "url": "https://www.ensembl.org/id/ENSBTAT00000008832.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008832.7", "url": "https://www.ensembl.org/id/ENSBTAP00000008832.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MHK9", "url": "https://www.uniprot.org/uniprotkb/F1MHK9" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "F1MHK9", "url": "https://www.uniprot.org/uniprotkb/F1MHK9" } ], "pmid": "" }, { "name": "ABC-type transporter activity", "id": "GO:0140359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140359", "evidence": [ { "database": "UniProtKB", "id": "F1MHK9", "url": "https://www.uniprot.org/uniprotkb/F1MHK9" } ], "pmid": "" }, { "name": "lipid transporter activity", "id": "GO:0005319", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005319", "evidence": [ { "database": "UniProtKB", "id": "F1MHK9", "url": "https://www.uniprot.org/uniprotkb/F1MHK9" } ], "pmid": "" }, { "name": "ATPase-coupled transmembrane transporter activity", "id": "GO:0042626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042626", "evidence": [ { "database": "UniProtKB", "id": "F1MHK9", "url": "https://www.uniprot.org/uniprotkb/F1MHK9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MHK9", "url": "https://www.uniprot.org/uniprotkb/F1MHK9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MHK9", "url": "https://www.uniprot.org/uniprotkb/F1MHK9" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "F1MHK9", "url": "https://www.uniprot.org/uniprotkb/F1MHK9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid transport", "id": "GO:0006869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006869", "evidence": [ { "database": "UniProtKB", "id": "F1MHK9", "url": "https://www.uniprot.org/uniprotkb/F1MHK9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1351, "end_pos": 1353, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1606, "end_pos": 1608, "annotation": "n_glycosylation_sequon" }, { "start_pos": 523, "end_pos": 525, "annotation": "n_glycosylation_sequon" }, { "start_pos": 693, "end_pos": 695, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "39051", "name": "", "equation": "cholesterol(in) + ATP + H2O = cholesterol(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "39051", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39051" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MHK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHK9" }, { "id": "PS50893", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50893" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ABC transporter", "eco_id": "ECO_0000259", "start_pos": 510, "end_pos": 743, "start_aa": "Ile", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 102, "end_pos": 104 }, { "start_pos": 122, "end_pos": 124 }, { "start_pos": 1351, "end_pos": 1353 }, { "start_pos": 1606, "end_pos": 1608 }, { "start_pos": 523, "end_pos": 525 }, { "start_pos": 693, "end_pos": 695 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPQ9-1", "uniprot_ac": "E1BPQ9", "uniprot_id": "E1BPQ9_BOVIN", "mass": { "chemical_mass": 39739.0, "monoisotopic_mass": 39739.0 }, "refseq": { "ac": "NP_001193707", "name": "immunoglobulin superfamily member 5 isoform 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193707" }, "gene_names": [ { "name": "IGSF5", "type": "recommended", "evidence": [ { "id": "E1BPQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPQ9" } ] }, { "name": "IGSF5", "type": "synonym", "evidence": [ { "id": "NP_001193707", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193707" } ] } ], "protein_names": [ { "name": "Immunoglobulin superfamily member 5", "type": "recommended", "evidence": [ { "id": "E1BPQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPQ9/entry#names_and_taxonomy" } ] }, { "name": "Junctional adhesion molecule 4", "type": "synonym", "evidence": [ { "id": "E1BPQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPQ9/entry#names_and_taxonomy" } ] }, { "name": "immunoglobulin superfamily member 5 isoform 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001193707", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193707" } ] } ], "function": [ { "annotation": "Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells.", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ9", "url": "https://www.uniprot.org/uniprotkb/E1BPQ9#function" }, { "database": "UniProtKB", "id": "ARBA00059983", "url": "https://www.uniprot.org/uniprotkb/ARBA00059983#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPQ9", "url": "https://www.uniprot.org/uniprotkb/E1BPQ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IGSF5", "url": "https://www.uniprot.org/uniprotkb/E1BPQ9", "locus": { "chromosome": "1", "start_pos": 139881435, "end_pos": 139827395, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002029", "url": "https://www.ensembl.org/id/ENSBTAG00000002029" } ] } } ], "crossref": [ { "id": "E1BPQ9", "url": "https://alphafold.ebi.ac.uk/entry/E1BPQ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002029", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002029", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511594", "url": "https://www.ncbi.nlm.nih.gov/gene/511594", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511594", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511594", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HSSYYFV", "url": "https://omabrowser.org/oma/group/HSSYYFV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M5F6", "url": "https://www.orthodb.org/?gene=A0A3Q1M5F6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MNM3", "url": "https://www.orthodb.org/?gene=A0A3Q1MNM3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E1BPQ9", "url": "https://www.orthodb.org/?gene=E1BPQ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44991", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44991", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44991:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44991:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193707", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5F6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5F6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5F6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5F6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNM3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNM3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPQ9", "url": "https://www.uniprot.org/uniprotkb/E1BPQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPQ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BPQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGAAERGVLAVLVVLAVLAACGSSSEIIEGPKNVTALKGSEARFNCTISQGWKLVMWALRGTVVLSMTPNETIITSDRFTSASYQEGGNFISEMIIHDVQLSDAGQVKCSLQNSNRDGAAFLSVQVMGQLLIPGGSLVVIEDKPCNVTCRALNWTLLPDLSWEIGVPVSHSSYYSIPEPEDLQSAVSVLALTPQGNGTVTCVAEMKGLDVRESVTVNLTVVQPPLDSIDKPGTSLPTWAIVLLAVSLSLLLILIIVLIIIFCCCVSRTEKEESSYQSQIRKSATVKTSKDTAGTKLKSANENYGYHSDESRTTQPASLHAKSSEAGVPEQCSSRQPHQESDHRQLGPANHPQVSFYVASPKKVRNVTLV", "length": 370, "header": "tr|E1BPQ9-1|E1BPQ9_BOVIN Isoform 1 of Immunoglobulin superfamily member 5 OS=Bos taurus OX=9913 GN=IGSF5 PE=3 SV=1 CANONICAL=E1BPQ9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M5F6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5F6/entry", "sequence": { "sequence": "MEGAAERGVLAVLVVLAVLAACGSSSEIIEGPKNVTALKGSEARFNCTISQGWKLVMWALRGTVVLSMTPNETIITSDRFTSASYQEGGNFISEMIIHDVQLSDAGQVKCSLQNSNRDGAAFLSVQESSYQSQIRKSATVKTSKDTAGTKLKSANENYGYHSDESRTTQPASLHAKSSEAGVPEQCSSRQPHQESDHRQLGPANHPQVSFYVASPKKVRNVTLV", "length": 224, "header": "tr|A0A3Q1M5F6-1|E1BPQ9_BOVIN Computationally mapped isoform of Immunoglobulin superfamily member 5 OS=Bos taurus OX=9913 GN=IGSF5 PE=3 SV=1 CANONICAL=E1BPQ9-1" }, "locus": { "chromosome": "1", "start_pos": 139879354, "end_pos": 139831370, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072169.1", "url": "https://www.ensembl.org/id/ENSBTAT00000072169.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063506.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063506.1" } ] } }, { "isoform_ac": "A0A3Q1MNM3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNM3/entry", "sequence": { "sequence": "MEGAAERGVLAVLVVLAVLAACGSSSEIIEGPKNVTALKGSEARFNCTISQGWKLVMWALRGTVVLSMTPNETIITSDRFTSASYQEGGNFISEMIIHDVQLSDAGQVKCSLQNSNRDGAAFLSVQDGRTSI", "length": 132, "header": "tr|A0A3Q1MNM3-1|E1BPQ9_BOVIN Computationally mapped isoform of Immunoglobulin superfamily member 5 OS=Bos taurus OX=9913 GN=IGSF5 PE=3 SV=1 CANONICAL=E1BPQ9-1" }, "locus": { "chromosome": "1", "start_pos": 139843685, "end_pos": 139831370, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084235.1", "url": "https://www.ensembl.org/id/ENSBTAT00000084235.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071165.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071165.1" } ] } }, { "isoform_ac": "E1BPQ9-1", "url": "https://www.uniprot.org/uniprotkb/E1BPQ9/entry", "sequence": { "sequence": "MEGAAERGVLAVLVVLAVLAACGSSSEIIEGPKNVTALKGSEARFNCTISQGWKLVMWALRGTVVLSMTPNETIITSDRFTSASYQEGGNFISEMIIHDVQLSDAGQVKCSLQNSNRDGAAFLSVQVMGQLLIPGGSLVVIEDKPCNVTCRALNWTLLPDLSWEIGVPVSHSSYYSIPEPEDLQSAVSVLALTPQGNGTVTCVAEMKGLDVRESVTVNLTVVQPPLDSIDKPGTSLPTWAIVLLAVSLSLLLILIIVLIIIFCCCVSRTEKEESSYQSQIRKSATVKTSKDTAGTKLKSANENYGYHSDESRTTQPASLHAKSSEAGVPEQCSSRQPHQESDHRQLGPANHPQVSFYVASPKKVRNVTLV", "length": 370, "header": "tr|E1BPQ9-1|E1BPQ9_BOVIN Isoform 1 of Immunoglobulin superfamily member 5 OS=Bos taurus OX=9913 GN=IGSF5 PE=3 SV=1 CANONICAL=E1BPQ9-1" }, "locus": { "chromosome": "1", "start_pos": 139879354, "end_pos": 139831370, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002629.5", "url": "https://www.ensembl.org/id/ENSBTAT00000002629.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002629.4", "url": "https://www.ensembl.org/id/ENSBTAP00000002629.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511594", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511594", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A5B2-1", "protein_name": "Immunoglobulin superfamily member 5", "gene_name": "IGSF5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGSCRGVLAALVVLAGLAACGSGNEILEGPRNVTVVKGSEARFNCTISQGWKLIMWALKGTVVLSVTPTEPIITNDRFTSASYEEGGNFISEMIIHDVQLSDAGQVKCSLQNSDRDGSAFLSVQVMGALLIPGGSLVVLAEEPCNVTCRAWGWTPLPDISWEIGAPVSHSSYDSAPEPDDLQSAVSVLALTPLGSGSVTCVADMKGLPLQESVTVNLTVVQPPLGSVDKPGTSLPTWAIALLAVSLSLLSILIIVLIIIFCCCCASRREKEESSYQSQIRKSASVKTNTETFQTKSGKENYGYSSDEPRTTTSLPPKGSESSVPEQRGSRPPHQGLDHRQPGPASRPQVSFNVASPKKVRNATLV", "length": 366 }, "evidence": [ { "id": "E1BPQ9", "url": "https://omabrowser.org/oma/group/E1BPQ9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YEJ1-1", "protein_name": "Immunoglobulin superfamily member 5", "gene_name": "IGSF5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MERFQKFILLPFILAASLTGLGFCYSILNGPTNATVLAGSEARFNCTVANGWAILIWLLNTNPVLTVINSHGPIETSDRFTSQSYNNSQSFTSELIIHNTQLNDSGRIECSIQKIDGSSFAFLSVQVNGTLLIKNSTLIVKENTTVEIVCEALGWAPAPDITWMTNDSLIDKSRYVTQQSQGSNSLYNALSVLTLTPMDTEILTCLADIETLPSPQNATIAVIVGNSTLENNYSEDSTSTWVIVLAVVFSIVGFILLIILIWVVVRCCCLKKGSTYENEVRKISVKKKTDDRLGSRQRSGSENQGYVPEEPPYTGQIPTVVSLPPMSTKFTVPRPDLHTSSAPKGRPQRHTDYPINPKKIRNVTHV", "length": 366 }, "evidence": [ { "id": "E1BPQ9", "url": "https://omabrowser.org/oma/group/E1BPQ9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5VJ70-1", "protein_name": "Immunoglobulin superfamily member 5", "gene_name": "Igsf5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGSWRDVLAVLVILAQLTVSGSSYQIIEGPRNVTALKGSEARFNCTVTHGWKLIMWALNGIVELSLTSQKPIITSNRFTSASYNSTDSFISEMIIHNVQLNDSGPVQCSLQNSNVFGFAFLSVQVMGTLNIPSSNLIVTEGEPCNVTCYAVGWTPLPNISWELEVPVSHSSYYSFLEPGNSLRVLSVLDLTPLGNGTLTCVAEMKDLQASESLTVNLTVVQPPPDSIGGEGQALPTWAIILLAVAFSLLLILIIALIIIFCCCCVSRREKEESTYQNEIRKSANVRTGKADPETWLKSGKENYGYKSDEARAAQIASLPPKSGEVSLPEQRSSLPQQELDKHRPSPVTHPRVSFDIASPQKIRNVTIV", "length": 369 }, "evidence": [ { "id": "E1BPQ9", "url": "https://omabrowser.org/oma/group/E1BPQ9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TSN7-1", "protein_name": "Immunoglobulin superfamily member 5", "gene_name": "Igsf5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGSWRDVLAVLVILAQLTASGSSYQIIEGPQNVTVLKDSEAHFNCTVTHGWKLLMWTLNQMVVLSLTTQGPIITNNRFTYASYNSTDSFISELIIHDVQPSDSGSVQCSLQNSHGFGSAFLSVQVMGTLNIPSNNLIVTEGEPCNVTCYAVGWTSLPDISWELEVPVSHSSYNSFLESGNFMRVLSVLDLTPLGNGTLTCVAELKDLQASKSLTVNLTVVQPPPDSIGEEGPALPTWAIILLAVAFSLLLILIIVLIIIFCCCCASRREKEESTYQNEIRKSANMRTNKADPETKLKGGKENYGYSSDEAKAAQTASLPPKSAEVSLPEKRSSSLPYQELNKHQPGPATHPRVSFDIASPQKVRNVTLV", "length": 370 }, "evidence": [ { "id": "E1BPQ9", "url": "https://omabrowser.org/oma/group/E1BPQ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NSI5-1", "protein_name": "Immunoglobulin superfamily member 5", "gene_name": "IGSF5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQKERSTADTLPDLEEWKSAAGLRWWQTAVVDGSGSGNEVIEGPQNARVLKGSQARFNCTVSQGWKLIMWALSDMVVLSVRPMEPIITNDRFTSQRYDQGGNFTSEMIIHNVEPSDSGNIRCSLQNSRLHGSAYLTVQVMGELFIPSVNLVVAENEPCEVTCLPSHWTRLPDISWELGLLVSHSSYYFVPEPSDLQSAVSILALTPQSNGTLTCVATWKSLKARKSATVNLTVIRCPQDTGGGINIPGVLSSLPSLGFSLPTWGKVGLGLAGTMLLTPTCTLTIRCCCCRRRCCGCNCCCRCCFCCRRKRGFRIQFQKKSEKEKTNKETETESGNENSGYNSDEQKTTDTASLPPKSCESSDPEQRNSSCGPPHQRADQRPPRPASHPQASFNLASPEKVSNTTVV", "length": 407 }, "evidence": [ { "id": "E1BPQ9", "url": "https://omabrowser.org/oma/group/E1BPQ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ9", "url": "https://www.uniprot.org/uniprotkb/E1BPQ9" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ9", "url": "https://www.uniprot.org/uniprotkb/E1BPQ9" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ9", "url": "https://www.uniprot.org/uniprotkb/E1BPQ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ9", "url": "https://www.uniprot.org/uniprotkb/E1BPQ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 366, "end_pos": 368, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPQ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 370, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPQ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPQ9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPQ9" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 126, "start_aa": "Ser", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 147, "end_pos": 149 }, { "start_pos": 154, "end_pos": 156 }, { "start_pos": 197, "end_pos": 199 }, { "start_pos": 218, "end_pos": 220 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 366, "end_pos": 368 }, { "start_pos": 46, "end_pos": 48 }, { "start_pos": 71, "end_pos": 73 } ] }, "class_list": [], "section_stats": [ { 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"count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MCL7-1", "uniprot_ac": "F1MCL7", "uniprot_id": "F1MCL7_BOVIN", "mass": { "chemical_mass": 170127.0, "monoisotopic_mass": 170127.0 }, "refseq": {}, "gene_names": [ { "name": "SHROOM2", "type": "recommended", "evidence": [ { "id": "F1MCL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCL7" } ] } ], "protein_names": [ { "name": "Shroom family member 2", "type": "synonym", "evidence": [ { "id": "F1MCL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCL7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MCL7", "url": "https://www.uniprot.org/uniprotkb/F1MCL7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SHROOM2", "url": "https://www.uniprot.org/uniprotkb/F1MCL7", "locus": { "chromosome": "X", "start_pos": 133111144, "end_pos": 133282716, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000211", "url": "https://www.ensembl.org/id/ENSBTAG00000000211" } ] } } ], "crossref": [ { "id": "ENSBTAG00000000211", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000211", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06750", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06750", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523644", "url": "https://www.ncbi.nlm.nih.gov/gene/523644", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014799", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014799", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014800", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027685", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027685", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:523644", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523644", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AVWHTRY", "url": "https://omabrowser.org/oma/group/AVWHTRY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M8Y2", "url": "https://www.orthodb.org/?gene=A0A3Q1M8Y2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MCL7", "url": "https://www.orthodb.org/?gene=F1MCL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15012", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15012", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15012:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15012:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08687", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08687", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08688", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08688", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M8Y2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8Y2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8Y2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8Y2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ14", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TQ14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ14-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCL7", "url": "https://www.uniprot.org/uniprotkb/F1MCL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCL7-1", "url": "https://www.uniprot.org/uniprotkb/F1MCL7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGAEPRARPERLAEAEARTADGGRLVEVQLSGGAPWGFTLKGGREHGEPLVITKVEEGSKAAAVDKLLAGDEIVGINDVGLSGFRQEAICLVKGSHKTLKLVVKRRNELNWRPHSWHATKFSDSQSEPAAPLLPCPSRPSRYHASSSSQDLSGGAWEPANLQRTSDHFSSLGSVDSLDPSSQPDPSGRLSAAKSSSSIDRLGGASKRDSAYGSFSTRSSTPDHTLPKADASSAENILYKVGLWEASAAADRRPGLAAGDPQGTEEPLGCFPPRVPEDGPEPKLAACGRSSSGPVWYVPDKRRAPPSPPPPPPPLRRDSFAATRIHEQTQGPTVSADAAPAQPLPGLSCVQPHGGDWKRPEPADQLLRPARGADGRRAASSGCAPGAHVDCGWPACDSGSRALLGAPSRLQASLSSTDVRRPQPSPVCQHPRHLSDEGPFFRKGPRATTWLGEPLPADCLGDNTPAAIVIGGPRAADQRGDCSAQSRYYCVMSRPGPQWGAPAPQPRCYPSRLEGAPGARQRSRADPVDRAPEDPPGAGLLDRGGRKRVVGSLDDGGGEICPLQTPMLHSLSRERACPPETRHKDMAPAPPEALAGKPLRRSDRFATTLRNEIQQRRARLQKSRSTATLASSAEEEGEVEDDVETEARGSWAQPVGAPETTFPSGTYKDHLKEAQARVLRATSFRRRDLDLSLADPEPAPRVWEGAPGARPPLCAAGSGSGSGSARIGSRRRFTAEQKLKSYSEPEKMNAVGLTGDQSPAPHDETLWTFADRWKFFEETSKPVGPQPGPRPAPCGFPREKPEMLWTVGPGKDGKAGRPIPPERLGTFAEYQASWREQRKVPEARGGGRYHSTDNILDVGVDQEERPQYVHERSRSSPSTDLYKQDASMEPRWEAGDPEEHTELSSAAPAEDRSPTPRQADGQRSEDHPGALRDPRQTSEPPGSREGPEVSLEARGRAGTLPRDYRYLEPRTPLEPPAQGQEPRPLSAAATARRPALQRPQPPKRELWPPPGDTPSRPHTSVASSEAVDTRSTRRVEEPTARPWREALLPAPFRPLQTSAMDSSRSPSPQFAPQKLTDKPPLLIQDENAARIERVMDNNTTVKMVPIKIVHSESQPEKESRQALARVPEPPPLPRGLERDQIKTLSTSEQSYSRFCPYSRQGAEPQPATGALGPPAKEGRASPPVLSYVKAKDRTADDLKSEELAREIAGRDKSLADILDPGVRMRTTMDLMEGIFPKDEHLLEGAQQRRKLLPKGPSPRTAEERREETSVLAAAPLATNSAYYSTSAPKAELLIKMKDLQEQQEPEEDSGSDLDHDLSVKKQELIESLGRKLQVLREARESLLEDVQANSALGDEVEALVKAVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDSTPPGDRQSLLEKQRVLIQQHEDARELKENLDRREGIVFDILVSYLGPESLADYEHFVKMKSALIIEQRELEDKIHLGTPFSCFFARVHPSLYRTGCQGSRHVPCQVRYADDTTLTGESKEELSVLMEVKEEREKAGLKLNIQKTKIMASGPITS", "length": 1560, "header": "tr|F1MCL7-1|F1MCL7_BOVIN Isoform 1 of Shroom family member 2 OS=Bos taurus OX=9913 GN=SHROOM2 PE=3 SV=4 CANONICAL=F1MCL7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M8Y2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8Y2/entry", "sequence": { "sequence": "MEGAEPRARPERLAEAEARTADGGRLVEVQLSGGAPWGFTLKGGREHGEPLVITKVEEGSKAAAVDKLLAGDEIVGINDVGLSGFRQEAICLVKGSHKTLKLVVKRRNELNWRPHSWHATKFSDSQSEPAAPLLPCPSRPSRYHASSSSQDLSGGAWEPANLQRTSDHFSSLGSVDSLDPSSQPDPSGRLSAAKSSSSIDRLGGASKRDSAYGSFSTRSSTPDHTLPKADASSAENILYKVGLWEASAAADRRPGLAAGDPQGTEEPLGCFPPRVPEDGPEPKLAACGRSSSGPVWYVPDKRRAPPSPPPPPPPLRRDSFAATRIHEQTQGPTVSADAAPAQPLPGLSCVQPHGGDWKRPEPADQLLRPARGADGRRAASSGCAPGAHVDCGWPACDSGSRALLGAPSRLQASLSSTDVRRPQPSPVCQHPRHLSDEGPFFRKGPRATTWLGEPLPADCLGDNTPAAIVIGGPRAADQRGDCSAQSRYYCVMSRPGPQWGAPAPQPRCYPSRLEGAPGARQRSRADPVDRAPEDPPGAGLLDRGGRKRVVGSLDDGGGEICPLQTPMLHSLSRERACPPETRHKDMAPAPPEALAGKPLRRSDRFATTLRNEIQQRRARLQKSRSTATLASSAEEEGEVEDDVETEARGSWAQPVGAPETTFPSGTYKDHLKEAQARVLRATSFRRRDLDLSLADPEPAPRVWEGAPGARPPLCAAGSGSGSGSARIGSRRRFTAEQKLKSYSEPEKMNAVGLTGDQSPAPHDETLWTFADRWKFFEETSKPVGPQPGPRPAPCGFPREKPEMLWTVGPGKDGKAGRPIPPERLGTFAEYQASWREQRKVPEARGGGRYHSTDNILDVGVDQEERPQYVHERSRSSPSTDLYKQDASMEPRWEAGDPEEHTELSSAAPAEDRSPTPRQADGQRSEDHPGALRDPRQTSEPPGSREGPEVSLEARGRAGTLPRDYRYLEPRTPLEPPAQGQEPRPLSAAATARRPALQRPQPPKRELWPPPGDTPSRPHTSVASSEAVDTRSTRRVEEPTARPWREALLPAPFRPLQTSAMDSSRSPSPQFAPQKLTDKPPLLIQDENAARIERVMDNNTTVKMVPIKIVHSESQPEKESRQALARVPEPPPLPRGLERDQIKTLSTSEQSYSRFCPYSRQGAEPQPATGALGPPAKEGRASPPVLSYVKAKDRTADDLKSEELAREIAGRDKSLADILDPGVRMRTTMDLMEGIFPKDEHLLEGAQQRRKLLPKGPSPRTAEERREETSVLAAAPLATNSAYYSTSAPKAELLIKMKDLQEQQEPEEDSGSDLDHDLSVKKQELIESLGRKLQVLREARESLLEDVQANSALGDEVEALVKAVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDSTPPGDRQSLLEKQRVLIQQHEDARELKENLDRREGIVFDILVSYLGPESLADYEHFVKMKSALIIEQRELEDKIHLGGQGKCESE", "length": 1491, "header": "tr|A0A3Q1M8Y2-1|F1MCL7_BOVIN Computationally mapped isoform of Shroom family member 2 OS=Bos taurus OX=9913 GN=SHROOM2 PE=3 SV=3 CANONICAL=F1MCL7-1" }, "locus": { "chromosome": "X", "start_pos": 133282517, "end_pos": 133129143, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076412.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076412.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066938.3", "url": "https://www.ensembl.org/id/ENSBTAP00000066938.3" } ] } }, { "isoform_ac": "A0AAA9TQ14-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQ14/entry", "sequence": { "sequence": "MEGAEPRARPERLAEAEARTADGGRLVEVQLSGGAPWGFTLKGGREHGEPLVITKVEEGSKAAAVDKLLAGDEIVGINDVGLSGFRQEAICLVKGSHKTLKLVVKRRNELNWRPHSWHATKFSDSQSEPAAPLLPCPSRPSRYHASSSSQDLSGGAWEPANLQRTSDHFSSLGSVDSLDPSSQPDPSGRLSAAKSSSSIDRLGGASKRDSAYGSFSTRSSTPDHTLPKADASSAENILYKVGLWEASAAADRRPGLAAGDPQGTEEPLGCFPPRVPEDGPEPKLAACGRSSSGPVWYVPDKRRAPPSPPPPPPPLRRDSFAATRIHEQTQGPTVSADAAPAQPLPGLSCVQPHGGDWKRPEPADQLLRPARGADGRRAASSGCAPGAHVDCGWPACDSGSRALLGAPSRLQASLSSTDVRRPQPSPVCQHPRHLSDEGPFFRKGPRATTWLGEPLPADCLGDNTPAAIVIGGPRAADQRGDCSAQSRYYCVMSRPGPQWGAPAPQPRCYPSRLEGAPGARQRSRADPVDRAPEDPPGAGLLDRGGRKRVVGSLDDGGGEICPLQTPMLHSLSRERACPPETRHKDMAPAPPEALAGKPLRRSDRFATTLRNEIQQRRARLQKSRSTATLASSAEEEGEVEDDVETEARGSWAQPVGAPETTFPSGTYKDHLKEAQARVLRATSFRRRDLDLSLADPEPAPRVWEGAPGARPPLCAAGSGSGSGSARIGSRRRFTAEQKLKSYSEPEKMNAVGLTGDQSPAPHDETLWTFADRWKFFEETSKPVGPQPGPRPAPCGFPREKPEMLWTVGPGKDGKAGRPIPPERLGTFAEYQASWREQRKVPEARGGGRYHSTDNILDVGVDQEERPQYVHERSRSSPSTDLYKQDASMEPRWEAGDPEEHTELSSAAPAEDRSPTPRQADGQRSEDHPGALRDPRQTSEPPGSREGPEVSLEARGRAGTLPRDYRYLEPRTPLEPPAQGQEPRPLSAAATARRPALQRPQPPKRELWPPPGDTPSRPHTSVASSEAVDTRSTRRVEEPTARPWREALLPAPFRPLQTSAMDSSRSPSPQFAPQKLTDKPPLLIQDENAARIERVMDNNTTVKMVPIKIVHSESQPEKESRQALARVPEPPPLPRGLERDQIKTLSTSEQSYSRFCPYSRQGAEPQPATGALGPPAKEGRASPPVLSYVKAKDRTADDLKSEELAREIAGRDKSLADILDPGVRMRTTMDLMEGIFPKDEHLLEGAQQRRKLLPKGPSPRTAEERREETSVLAAAPLATNSAYYSTSAPKAELLIKMKDLQEQQEPEEDSGSDLDHDLSVKKQELIESLGRKLQVLREARESLLEDVQANSALGDEVEALVKAVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDSTPPGDRQSLLEKQRVLIQQHEDARELKENLDRREGIVFDILVSYLGPESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDSLQPERGK", "length": 1500, "header": "tr|A0AAA9TQ14-1|F1MCL7_BOVIN Computationally mapped isoform of Shroom family member 2 OS=Bos taurus OX=9913 GN=SHROOM2 PE=3 SV=1 CANONICAL=F1MCL7-1" }, "locus": { "chromosome": "X", "start_pos": 133282517, "end_pos": 133143244, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088858.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088858.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099118.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099118.1" } ] } }, { "isoform_ac": "F1MCL7-1", "url": "https://www.uniprot.org/uniprotkb/F1MCL7/entry", "sequence": { "sequence": "MEGAEPRARPERLAEAEARTADGGRLVEVQLSGGAPWGFTLKGGREHGEPLVITKVEEGSKAAAVDKLLAGDEIVGINDVGLSGFRQEAICLVKGSHKTLKLVVKRRNELNWRPHSWHATKFSDSQSEPAAPLLPCPSRPSRYHASSSSQDLSGGAWEPANLQRTSDHFSSLGSVDSLDPSSQPDPSGRLSAAKSSSSIDRLGGASKRDSAYGSFSTRSSTPDHTLPKADASSAENILYKVGLWEASAAADRRPGLAAGDPQGTEEPLGCFPPRVPEDGPEPKLAACGRSSSGPVWYVPDKRRAPPSPPPPPPPLRRDSFAATRIHEQTQGPTVSADAAPAQPLPGLSCVQPHGGDWKRPEPADQLLRPARGADGRRAASSGCAPGAHVDCGWPACDSGSRALLGAPSRLQASLSSTDVRRPQPSPVCQHPRHLSDEGPFFRKGPRATTWLGEPLPADCLGDNTPAAIVIGGPRAADQRGDCSAQSRYYCVMSRPGPQWGAPAPQPRCYPSRLEGAPGARQRSRADPVDRAPEDPPGAGLLDRGGRKRVVGSLDDGGGEICPLQTPMLHSLSRERACPPETRHKDMAPAPPEALAGKPLRRSDRFATTLRNEIQQRRARLQKSRSTATLASSAEEEGEVEDDVETEARGSWAQPVGAPETTFPSGTYKDHLKEAQARVLRATSFRRRDLDLSLADPEPAPRVWEGAPGARPPLCAAGSGSGSGSARIGSRRRFTAEQKLKSYSEPEKMNAVGLTGDQSPAPHDETLWTFADRWKFFEETSKPVGPQPGPRPAPCGFPREKPEMLWTVGPGKDGKAGRPIPPERLGTFAEYQASWREQRKVPEARGGGRYHSTDNILDVGVDQEERPQYVHERSRSSPSTDLYKQDASMEPRWEAGDPEEHTELSSAAPAEDRSPTPRQADGQRSEDHPGALRDPRQTSEPPGSREGPEVSLEARGRAGTLPRDYRYLEPRTPLEPPAQGQEPRPLSAAATARRPALQRPQPPKRELWPPPGDTPSRPHTSVASSEAVDTRSTRRVEEPTARPWREALLPAPFRPLQTSAMDSSRSPSPQFAPQKLTDKPPLLIQDENAARIERVMDNNTTVKMVPIKIVHSESQPEKESRQALARVPEPPPLPRGLERDQIKTLSTSEQSYSRFCPYSRQGAEPQPATGALGPPAKEGRASPPVLSYVKAKDRTADDLKSEELAREIAGRDKSLADILDPGVRMRTTMDLMEGIFPKDEHLLEGAQQRRKLLPKGPSPRTAEERREETSVLAAAPLATNSAYYSTSAPKAELLIKMKDLQEQQEPEEDSGSDLDHDLSVKKQELIESLGRKLQVLREARESLLEDVQANSALGDEVEALVKAVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDSTPPGDRQSLLEKQRVLIQQHEDARELKENLDRREGIVFDILVSYLGPESLADYEHFVKMKSALIIEQRELEDKIHLGTPFSCFFARVHPSLYRTGCQGSRHVPCQVRYADDTTLTGESKEELSVLMEVKEEREKAGLKLNIQKTKIMASGPITS", "length": 1560, "header": "tr|F1MCL7-1|F1MCL7_BOVIN Isoform 1 of Shroom family member 2 OS=Bos taurus OX=9913 GN=SHROOM2 PE=3 SV=4 CANONICAL=F1MCL7-1" }, "locus": { "chromosome": "X", "start_pos": 133282517, "end_pos": 133134709, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000256.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000256.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000256.7", "url": "https://www.ensembl.org/id/ENSBTAP00000000256.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 333, "start_aa": "Thr", "end_pos": 333, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr333", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:523644", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:523644", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "K7GQZ0-1", "protein_name": "Shroom family member 2", "gene_name": "SHROOM2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGAEPRAQPERLAEAEARAADGWRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVGKLLAGDEIVGINDVGLSGFRQEAICLVKGSHKTLKLVVKRRNELSWRPHSWHATKFSDGHPESSTSSLSSSSTCPAWPGRHHASSSSQDLSGSAWEQTNLQRASGHFSSLGSVDSLDQPAQSSPSGRLSAAKSNSSIDHLGGPSKRDSAYGSFSTSSSTPDHTLPKADASSAENILYKVGLWEASAAGGGRQGLTAGDPQGVEERLGCFPPRVPCDSSRSPRPENSAEPKLAASGRSTFGPVWYVPEKKKAPSSPPPPPPPLRRDSFAATKSHEKTQGPFAEAATSQHFPGLVGAQAHGDWRPEVAEHLQRPGPANDARRAGGSGWVPGAYLDYGWPPCDSGAPSRLQASLSSTDVRCPQASYRCQHPRHSSDESPFCREGPRATTWLREQPPAEGFQDDSPTQVGWPSAADRKGDGGAQSRYYCVTSRRCLQGGAPDAQPRSYPSGFEGAPGARQRGRAMPADRAAGATELPSGSLLDKASLKKVAGDFTWADQGGGEICPLQTPMLHSLTREGARRPEPSFDGAAERLALEAPAGKPMRRSDRFATTLRNEIQLRRARLQKSRSTATLAGPGAEEEEEEEEEEAEVRGWGAHQAGGAGTAPEATVTSSYKDHLKEAQARVLRATSFRRRDLEPSHVDPDTGPRVREVAPARPPSCATSGGGSALPAPRIGGRRRFTAAQKLKSYSEPEKMNEVGLAGDDPPRRYPGPPDETVRTFADRWKFFEETSKPTGQRPGRRPGPCGFPKEKPERPQTAGPGNGGKAGRSDPPQRLGTFAEYQASWREQRKAPEARSAGRYHSADDILEVGLDQQERPPYIHERSRSSPSTDLYKQEASVDLRREAEEPREQRELFSAVLAEEGRPPQRQADARCVEDAPGAQKPSPVSEVPEGPREGRSRAGTLPRDYTFSEDPAPSAPHARGQDPPPVSAAPLAKKPAPQRPPPPKREPRPFRGPAGAPAAGAPAAPPLGGRPCPPASPAAPDVCLEHPRSAGASVAKPSAAQPAPARPSGEPGGAHVEERTAGAQREALLPARFRPLPTAAMETSRSPSPQFAPQKLTDKPPLLVQDENNTRIERVMENNTTVKMVPIKIVHSESQPARDSRQGLARAAAEPPALPSGLERDQIKTLSTSEQSYSRFCLYSRQGAAPPAPGAPAPPARDGRASPPALGYAKARERTAEDLKSEELAREIAGKDKSLADILDPSVKIRTTMDLMEGIFPKDEHLLEEAQQRRKLLPKVPSPRSAEERKEEPSVPAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEPEEDSGSDLDHDLSVKKQELIESLGRKLRVLREARQSLLEDIQANSALGDEVEALAKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDSASASDRQSLLEKQRVLVQQHEDAKELKENLDRREGIVFDILASYLSQESLADYEHFVKMKSALIIEQRELDDKIHLGEEQLKCLLDSLQPERGK", "length": 1547 }, "evidence": [ { "id": "F1MCL7", "url": "https://omabrowser.org/oma/group/F1MCL7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q13796-1", "protein_name": "Protein Shroom2", "gene_name": "SHROOM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGAEPRARPERLAEAETRAADGGRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQEAICLVKGSHKTLKLVVKRRSELGWRPHSWHATKFSDSHPELAASPFTSTSGCPSWSGRHHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDSLDHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSSTPDHTLSKADTSSAENILYTVGLWEAPRQGGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGPVWYVPDKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDRRPELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVRFPQSPHSGRHPPLYSDHSPLCADSLGQEPGAASFQNDSPPQVRGLSSCDQKLGSGWQGPRPCVQGDLQAAQLWAGCWPSDTALGALESLPPPTVGQSPRHHLPQPEGPPDARETGRCYPLDKGAEGCSAGAQEPPRASRAEKASQRLAASITWADGESSRICPQETPLLHSLTQEGKRRPESSPEDSATRPPPFDAHVGKPTRRSDRFATTLRNEIQMHRAKLQKSRSTVALTAAGEAEDGTGRWRAGLGGGTQEGPLAGTYKDHLKEAQARVLRATSFKRRDLDPNPGDLYPESLEHRMGDPDTVPHFWEAGLAQPPSSTSGGPHPPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSPHQHPRTSEDTVGTFADRWKFFEETSKPVPQRPAQKQALHGIPRDKPERPRTAGRTCEGTEPWSRTTSLGDSLNAHSAAEKAGTSDLPRRLGTFAEYQASWKEQRKPLEARSSGRCHSADDILDVSLDPQERPQHVHGRSRSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCLYTRQGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKEKTVEDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRSTEERKEEPSVPAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEHEEDSGSDLDHDLSVKKQELIESISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDAKELKENLDRRERIVFDILANYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDSLQPERGK", "length": 1616 }, "evidence": [ { "id": "F1MCL7", "url": "https://omabrowser.org/oma/group/F1MCL7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TP36-1", "protein_name": "Protein Shroom2", "gene_name": "Shroom2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRPSTVTSRIWWSESSSSSSHDLSGSWEHTSLQRTSDHFSSMGSIDSLDHSSQLYPSGHLSSAKSNSSIDHLGGHSKRDSAYGSFSTCSSTPDHTLPKADASSTENILYKVGLWEASRPGSSRQSQSTGDPQGLQDRPSSFLPRVPGNSSKSPRPEDNIEPKIATSGRSNFGPVWYVPDKKKAPSPPPLGLPLRSDSFAVAARGHEKARGPPFSDLASMQHFTTLPHVQPRGDRRMETTDRQWKLAHPSSGKEIGNVGYQPEGHLDCRWLCSDDRAGRPSGAPGRHQFSLSSTDVHFLKSYHGSQHPQPCSDESPRFPSSPRELLRITPSGCLQEPPELSQDDNPAQVRWPGSVNQKLDDRGRSHYFSVPHRQPVHGSAHVLIPRSDYWHSDTTPVDLECPLLRPDQRGYPQQYEETPASHERGGYQQLNAGIEGCCSGIHEPPRASHTVRAGLQCPGNDFKLVDAESGRISRQRTPMLHSLTQDGAWRPGNSKDCGNEKPPLLDAQVGKPTRRSDRFATTLRNEIQMRRAKLQKSKSTVTLAGDSEAEDCAGDWRVDVGAVPEGSFPSTYKEHLKEAQTRVLKATSFQRRDLDPTPADQYPGPPEHRTCDHSASSSLSSFPGEPDSAPRLCEAGLAKPPSSAGGVPHILRIGGRKRFTAEQKLKSYSEPEKINEVGLSGDHSPHPTIRTSEDSVGTFADRWKFFEETSKSLLQKPGHRQAFCGIPREKAERPQTQGHECESTEPWFQKRSRATSCGEILSEDRKVEKASEKLNPPRRLGTFAEYQASWKEQKKSLEARSSGRYHSADDILDAGLDQQQRPQYIHERSRSSPSTDHYSQEVPVEPNRQAEDSGGQKEALLCTLQAEEGCSAPSSSVLSSAQPQDSQHVNEDPTSPQPEAQLSSKCQHLQTSTMETSRSPSPQFAPQKLTDKPPLLIHEDNSARYCPVTACYVFIPCRLQVFVAGALPQLQTLGIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAELPALPSGLEKDQIKTLSTSEQCYSRFCVYTRQEVETPHRARPPEPQPPSTPAPPVRDSCSSPPSLNYGKAKEKTVDDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPSPRVTEDNSCPSLSAICYNLGTRSKSVPVSQLIKIKILASSPRKQDPGMPGVVSLATNSTYYSTSAPKAELLIKMKDLQEPEEYSAGDLDHDLSIKKQELIDSISRKLQVLREARESLLEDIQANNALGDEVEAIVKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDSPSPGDRQSLLEKQRVLTQQHEDAKELKENLDRRERIVFDILATYLSEENLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLFDSLQPERSK", "length": 1423 }, "evidence": [ { "id": "F1MCL7", "url": "https://omabrowser.org/oma/group/F1MCL7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "F1MCL7", "url": "https://www.uniprot.org/uniprotkb/F1MCL7" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "F1MCL7", "url": "https://www.uniprot.org/uniprotkb/F1MCL7" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "F1MCL7", "url": "https://www.uniprot.org/uniprotkb/F1MCL7" } ], "pmid": "" }, { "name": "cortical actin cytoskeleton", "id": "GO:0030864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030864", "evidence": [ { "database": "UniProtKB", "id": "F1MCL7", "url": "https://www.uniprot.org/uniprotkb/F1MCL7" } ], "pmid": "" }, { "name": "apical junction complex", "id": "GO:0043296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043296", "evidence": [ { "database": "UniProtKB", "id": "F1MCL7", "url": "https://www.uniprot.org/uniprotkb/F1MCL7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "F1MCL7", "url": "https://www.uniprot.org/uniprotkb/F1MCL7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "F1MCL7", "url": "https://www.uniprot.org/uniprotkb/F1MCL7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1097, "end_pos": 1099, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1098, "end_pos": 1100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MCL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCL7" }, { "id": "PS51306", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51306" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ASD1", "eco_id": "ECO_0000259", "start_pos": 671, "end_pos": 752, "start_aa": "Leu", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MCL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCL7" }, { "id": "PS51307", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51307" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ASD2", "eco_id": "ECO_0000259", "start_pos": 1201, "end_pos": 1495, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MCL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCL7" }, { "id": "PS50106", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50106" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PDZ", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 108, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 333 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1097, "end_pos": 1099 }, { "start_pos": 1098, "end_pos": 1100 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MEI8-1", "uniprot_ac": "F1MEI8", "uniprot_id": "F1MEI8_BOVIN", "mass": { "chemical_mass": 100538.0, "monoisotopic_mass": 100538.0 }, "refseq": { "ac": "XP_003586709", "name": "general transcription factor 3C polypeptide 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586709" }, "gene_names": [ { "name": "GTF3C2", "type": "recommended", "evidence": [ { "id": "F1MEI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEI8" } ] }, { "name": "GTF3C2", "type": "synonym", "evidence": [ { "id": "XP_003586709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586709" } ] } ], "protein_names": [ { "name": "General transcription factor 3C polypeptide 2", "type": "recommended", "evidence": [ { "id": "F1MEI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEI8/entry#names_and_taxonomy" } ] }, { "name": "TF3C-beta", "type": "synonym", "evidence": [ { "id": "F1MEI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEI8/entry#names_and_taxonomy" } ] }, { "name": "Transcription factor IIIC subunit beta", "type": "synonym", "evidence": [ { "id": "F1MEI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEI8/entry#names_and_taxonomy" } ] }, { "name": "general transcription factor 3C polypeptide 2", "type": "synonym", "evidence": [ { "id": "XP_003586709", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586709" } ] } ], "function": [ { "annotation": "Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.", "evidence": [ { "database": "UniProtKB", "id": "F1MEI8", "url": "https://www.uniprot.org/uniprotkb/F1MEI8#function" }, { "database": "UniProtKB", "id": "ARBA00053668", "url": "https://www.uniprot.org/uniprotkb/ARBA00053668#function" }, { "database": "UniProtKB", "id": "A0A3Q1MB06", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB06#function" }, { "database": "UniProtKB", "id": "A0AAA9T3M7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3M7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MEI8", "url": "https://www.uniprot.org/uniprotkb/F1MEI8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GTF3C2", "url": "https://www.uniprot.org/uniprotkb/F1MEI8", "locus": { "chromosome": "11", "start_pos": 72325010, "end_pos": 72308977, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017283", "url": "https://www.ensembl.org/id/ENSBTAG00000017283" } ] } } ], "crossref": [ { "id": "F1MEI8", "url": "https://alphafold.ebi.ac.uk/entry/F1MEI8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017283", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017283", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "782752", "url": "https://www.ncbi.nlm.nih.gov/gene/782752", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052416", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052416", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:782752", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782752", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MB06", "url": "https://www.orthodb.org/?gene=A0A3Q1MB06", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MEI8", "url": "https://www.orthodb.org/?gene=F1MEI8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15052", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15052", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15052:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15052:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-76061", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76061", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-76066", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76066", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_003586709", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586709", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MB06", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB06", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MB06-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB06-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3M7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3M7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3M7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3M7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEI8", "url": "https://www.uniprot.org/uniprotkb/F1MEI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEI8-1", "url": "https://www.uniprot.org/uniprotkb/F1MEI8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDTYGVGYMALEEAGPVGNMTVVDSPGQEVLNQLDVKASSETTSVEASIEMPLSTPFPGYEDSLDERRLLPEQESLSRLQQQDLSSEMSKVPKPRASKPGPKRGGRTRKGPKRPQQPNSPSAPRVPGLLDQSNPLSTPMPKKRGRKSKADLLLLKLSKGLDQPESPHPKMPPEDFETPPGERPRRRAAQVALLYLQELAEELSTALPTPVSCPEGPQVSSPTQPKIIQPQAACLRGEGDNTARDEDFVLQVEAEEAEESEAPSENSSDPEPAAPRSTTRGSTQKQKPHVRGMAHNGLPNHIMAPVWKCLHLTKDIRDQKHSYWEFAEWIPLAWKWRLLSELEAAPYLPQEEKSPLFSVQREGLPEDGTLYRINRFSSITAHPERLDVSFFTGGPLWALDWCPVPEGSAASQYVALFSSPDMNETHSLSQLYSGPGLLQLWDLGTLQQESCLGNRAHFVYGIACDHGCIWDLKFCPSGAWELPGTPRKAPLLPRLGLLALACSDGKVLLFSLPHPEALLAQQPLDAVKPAIYKVHCVATLQVGSMQASEPSECGQCLSLAWMPTRPHHHLAAGYYNGMVVLWNLPTNSPLQRIRLSDGSLKLYPFQCFLAHDQAVRTLQWCKANSHFLASAGSDRKIKFWDLRRPYEPINSIKRFLSTELAWLLPYNGVTVAQDNCYASYGLCGIHYIDAGYLGFKAYFTAPRKGTVWSLSGSDWLGTIAAGDISGELIAAILPDMALNPTNVKRPLDRRFPIYKADLIPYQDSPEGQDHTSASSGAPNPPKARTYAETVNHHYLLFQDTDLRSFHGLPHREPMLRMQEGEGQTRLCLDRLQLEAIHKVRFSPNLDSYGWLVSGGQSGLVRIHFVRGLTCPLGHRMQLESRAHFSAMFQLASPSPGPGFPPTSHCLLPGP", "length": 909, "header": "tr|F1MEI8-1|F1MEI8_BOVIN Isoform 1 of General transcription factor 3C polypeptide 2 OS=Bos taurus OX=9913 GN=GTF3C2 PE=4 SV=3 CANONICAL=F1MEI8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MB06-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB06/entry", "sequence": { "sequence": "MDTYGVGYMALEEAGPVGNMTVVDSPGQEVLNQLDVKASSETTSVEASIEMPLSTPFPGYEDSLDERRLLPEQESLSRLQQQDLSSEMSKVPKPRASKPGPKRGGRTRKGPKRPQQPNSPSAPRVPGLLDQSNPLSTPMPKKRGRKSKADLLLLKLSKGLDQPESPHPKMPPEDFETPPGERPRRRAAQVALLYLQELAEELSTALPTPVSCPEGPQVEAEEAEESEAPSENSSDPEPAAPRSTTRGSTQKQKPHVRGMAHNGLPNHIMAPVWKCLHLTKDIRDQKHSYWEFAEWIPLAWKWRLLSELEAAPYLPQEEKSPLFSVQREGLPEDGTLYRINRFSSITAHPERLDVSFFTGGPLWALDWCPVPEGSAASQYVALFSSPDMNETHSLSQLYSGPGLLQLWDLGTLQQESCLGNRAHFVYGIACDHGCIWDLKFCPSGAWELPGTPRKAPLLPRLGLLALACSDGKVLLFSLPHPEALLAQQPLDAVKPAIYKVHCVATLQVGSMQASEPSECGQCLSLAWMPTRPHHHLAAGYYNGMVVLWNLPTNSPLQRIRLSDGSLKLYPFQCFLAHDQAVRTLQWCKANSHFLASAGSDRKIKFWDLRRPYEPINSIKRFLSTELAWLLPYNGVTVAQDNCYASYGLCGIHYIDAGYLGFKAYFTAPRKGTVWSLSGSDWLGTIAAGDISGELIAAILPDMALNPTNVKRPLDRRFPIYKADLIPYQDSPEGQDHTSASSGAPNPPKARTYAETVNHHYLLFQDTDLRSFHGLPHREPMLRMQEGEGQTRLCLDRLQLEAIHKVRFSPNLDSYGWLVSGGQSGLVRIHFVRGLTCPLGHRMQLESRAHFSAMFQLASPSPGPGFPPTSHCLLPGP", "length": 876, "header": "tr|A0A3Q1MB06-1|F1MEI8_BOVIN Computationally mapped isoform of General transcription factor 3C polypeptide 2 OS=Bos taurus OX=9913 GN=GTF3C2 PE=4 SV=2 CANONICAL=F1MEI8-1" }, "locus": { "chromosome": "11", "start_pos": 72320806, "end_pos": 72309006, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074012.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074012.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065826.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065826.2" } ] } }, { "isoform_ac": "A0AAA9T3M7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3M7/entry", "sequence": { "sequence": "MDTYGVGYMALEEAGPVGNMTVVDSPGQEVLNQLDVKASSETTSVEASIEMPLSTPFPGYEDSLDERRLLPEQESLSRLQQQDLSSEMSKVPKPRASKPGPKRGGRTRKGPKRPQQPNSPSAPRVPGLLDQSNPLSTPMPKKRGRKSKADLLLLKLSKGLDQPESPHPKMPPEDFETPPGERPRRRAAQVALLYLQELAEELSTALPTPVSCPEGPQVSSPTQPKIIQPQAACLRGEGDNTARDEDFVLQVEAEEAEESEAPSENSSDPEPAAPRSTTRGSTQKQKPHVRGMAHNGLPNHIMAPVWKCLHLTKDIRDQKHSYWEFAEWIPLAWKWRLLSELEAAPYLPQEEKSPLFSVQREGLPEDGTLYRINRFSSITAHPERLDVSFFTGGPLWALDWCPVPEGSAASQYVALFSSPDMNETHSLSQLYSGPGLLQLWDLGTLQQESCLGNRAHFVYGIACDHGCIWDLKFCPSGAWELPGTPRKAPLLPRLGLLALACSDGKVLLFSLPHPEALLAQQPLDAVKPAIYKVHCVATLQVGSMQASEPSECGQCLSLAWMPTRPHHHLAAGYYNGMVVLWNLPTNSPLQRIRLSDGSLKLYPFQCFLAHDQAVRTLQWCKANSHFLASAGSDRKIKFWDLRRPYEPINSIKRFLSTELAWLLPYNGVTVAQDNCYASYGLCGIHYIDAGYLGFKAYFTAPRKGTVWSLSGSDWLGTIAAGDISGELIAAILPDMALNPTNVKRPLDRRFPIYKADLIPYQDSPEGQDHTSASSGAPNPPKARTYAETVNHHYLLFQDTDLRSFHGLPHREPMLRMQEGEGQTRLCLDRLQLEAIHKRLGPLLFWPWTQGKPNSQPSGQGGTWGGSPSAHSGHVGEAALAPR", "length": 882, "header": "tr|A0AAA9T3M7-1|F1MEI8_BOVIN Computationally mapped isoform of General transcription factor 3C polypeptide 2 OS=Bos taurus OX=9913 GN=GTF3C2 PE=4 SV=1 CANONICAL=F1MEI8-1" }, "locus": { "chromosome": "11", "start_pos": 72324974, "end_pos": 72309006, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117839.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117839.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091247.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091247.1" } ] } }, { "isoform_ac": "F1MEI8-1", "url": "https://www.uniprot.org/uniprotkb/F1MEI8/entry", "sequence": { "sequence": "MDTYGVGYMALEEAGPVGNMTVVDSPGQEVLNQLDVKASSETTSVEASIEMPLSTPFPGYEDSLDERRLLPEQESLSRLQQQDLSSEMSKVPKPRASKPGPKRGGRTRKGPKRPQQPNSPSAPRVPGLLDQSNPLSTPMPKKRGRKSKADLLLLKLSKGLDQPESPHPKMPPEDFETPPGERPRRRAAQVALLYLQELAEELSTALPTPVSCPEGPQVSSPTQPKIIQPQAACLRGEGDNTARDEDFVLQVEAEEAEESEAPSENSSDPEPAAPRSTTRGSTQKQKPHVRGMAHNGLPNHIMAPVWKCLHLTKDIRDQKHSYWEFAEWIPLAWKWRLLSELEAAPYLPQEEKSPLFSVQREGLPEDGTLYRINRFSSITAHPERLDVSFFTGGPLWALDWCPVPEGSAASQYVALFSSPDMNETHSLSQLYSGPGLLQLWDLGTLQQESCLGNRAHFVYGIACDHGCIWDLKFCPSGAWELPGTPRKAPLLPRLGLLALACSDGKVLLFSLPHPEALLAQQPLDAVKPAIYKVHCVATLQVGSMQASEPSECGQCLSLAWMPTRPHHHLAAGYYNGMVVLWNLPTNSPLQRIRLSDGSLKLYPFQCFLAHDQAVRTLQWCKANSHFLASAGSDRKIKFWDLRRPYEPINSIKRFLSTELAWLLPYNGVTVAQDNCYASYGLCGIHYIDAGYLGFKAYFTAPRKGTVWSLSGSDWLGTIAAGDISGELIAAILPDMALNPTNVKRPLDRRFPIYKADLIPYQDSPEGQDHTSASSGAPNPPKARTYAETVNHHYLLFQDTDLRSFHGLPHREPMLRMQEGEGQTRLCLDRLQLEAIHKVRFSPNLDSYGWLVSGGQSGLVRIHFVRGLTCPLGHRMQLESRAHFSAMFQLASPSPGPGFPPTSHCLLPGP", "length": 909, "header": "tr|F1MEI8-1|F1MEI8_BOVIN Isoform 1 of General transcription factor 3C polypeptide 2 OS=Bos taurus OX=9913 GN=GTF3C2 PE=4 SV=3 CANONICAL=F1MEI8-1" }, "locus": { "chromosome": "11", "start_pos": 72320806, "end_pos": 72309006, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022977.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022977.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022977.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022977.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 669, "start_aa": "Thr", "end_pos": 669, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr669", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:782752", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782752", "resource": "KEGG Pathway" }, { "id": "R-BTA-76061", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76061", "resource": "Reactome", "description": "RNA Polymerase III Transcription Initiation From Type 1 Promoter" }, { "id": "R-BTA-76066", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76066", "resource": "Reactome", "description": "RNA Polymerase III Transcription Initiation From Type 2 Promoter" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MEI8", "url": "https://www.uniprot.org/uniprotkb/F1MEI8" } ], "pmid": "" }, { "name": "transcription factor TFIIIC complex", "id": "GO:0000127", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000127", "evidence": [ { "database": "UniProtKB", "id": "F1MEI8", "url": "https://www.uniprot.org/uniprotkb/F1MEI8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MEI8", "url": "https://www.uniprot.org/uniprotkb/F1MEI8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MEI8", "url": "https://www.uniprot.org/uniprotkb/F1MEI8" } ], "pmid": "" }, { "name": "transcription by RNA polymerase III", "id": "GO:0006383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006383", "evidence": [ { "database": "UniProtKB", "id": "F1MEI8", "url": "https://www.uniprot.org/uniprotkb/F1MEI8" } ], "pmid": "" }, { "name": "transcription initiation at RNA polymerase III promoter", "id": "GO:0006384", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006384", "evidence": [ { "database": "UniProtKB", "id": "F1MEI8", "url": "https://www.uniprot.org/uniprotkb/F1MEI8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MEI8", "url": "https://www.uniprot.org/uniprotkb/F1MEI8" } ], "pmid": "" }, { "name": "RNA polymerase III general transcription initiation factor activity", "id": "GO:0000995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000995", "evidence": [ { "database": "UniProtKB", "id": "F1MEI8", "url": "https://www.uniprot.org/uniprotkb/F1MEI8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MEI8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 909, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MEI8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MEI8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 669 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 19, "end_pos": 21 }, { "start_pos": 265, "end_pos": 267 }, { "start_pos": 422, "end_pos": 424 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MDS5-1", "uniprot_ac": "F1MDS5", "uniprot_id": "F1MDS5_BOVIN", "mass": { "chemical_mass": 84746.0, "monoisotopic_mass": 84746.0 }, "refseq": { "ac": "XP_024855803", "name": "leucine-rich repeat and calponin homology domain-containing protein 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855803" }, "gene_names": [ { "name": "LRCH1", "type": "recommended", "evidence": [ { "id": "F1MDS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS5" } ] }, { "name": "LRCH1", "type": "synonym", "evidence": [ { "id": "XP_024855803", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855803" } ] } ], "protein_names": [ { "name": "Leucine rich repeats and calponin homology domain containing 1", "type": "synonym", "evidence": [ { "id": "F1MDS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS5/entry#names_and_taxonomy" } ] }, { "name": "leucine-rich repeat and calponin homology domain-containing protein 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024855803", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855803" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MDS5", "url": "https://www.uniprot.org/uniprotkb/F1MDS5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRCH1", "url": "https://www.uniprot.org/uniprotkb/F1MDS5", "locus": { "chromosome": "12", "start_pos": 16706785, "end_pos": 16492685, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002959", "url": "https://www.ensembl.org/id/ENSBTAG00000002959" } ] } } ], "crossref": [ { "id": "F1MDS5", "url": "https://alphafold.ebi.ac.uk/entry/F1MDS5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002959", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002959", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21270", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21270", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21271", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21271", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505325", "url": "https://www.ncbi.nlm.nih.gov/gene/505325", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001715", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036872", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KEDVCHR", "url": "https://omabrowser.org/oma/group/KEDVCHR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCI2", "url": "https://www.orthodb.org/?gene=A0A3Q1MCI2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MDS5", "url": "https://www.orthodb.org/?gene=F1MDS5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48051:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48051:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024855803", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855803", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCI2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCI2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCI2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDS5", "url": "https://www.uniprot.org/uniprotkb/F1MDS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDS5-1", "url": "https://www.uniprot.org/uniprotkb/F1MDS5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATPGSEPQPFVSALSVATLHPHHHPHHHHHHHGGTGASGGAAGGGGGGGGGGGGGFNLPLNRGLERALEEAANSGGLNLSARKLKEFPRTAAPAHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIINLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTTDSLYLHTMERPHLHQQVEDGKKDSDSGVGSDNGDKRLSATEPSDEDAVSLNVPMSNIMEEEQMKEDSCHRLSPVQGGFHQEFQPAPSLVSDSDNSGEDRGQFSHGKDVIHSEFINYMKEKTEACEELLRIEEDAHWPSEGTISASKDQDLDIAMIEQLREAVDLLQDPSRLSTDITERSVVNFYPVDPADDLELQDSTLNGQIQLERSPECEAQNDLTLQSNGSEYSPNEMRENSPASSPTNTSTALFGLKPRSDPALTLPPISFNKLTQAQTWDSSSYCVPSAGDSDNVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDGVVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEADLCSPYDILQLDFRHIRKTVDTLLALGEKPPQPTSALRSRDLISFCLVHILFIVLIYITYRWNALPP", "length": 765, "header": "tr|F1MDS5-1|F1MDS5_BOVIN Isoform 1 of Leucine rich repeats and calponin homology domain containing 1 OS=Bos taurus OX=9913 GN=LRCH1 PE=4 SV=3 CANONICAL=F1MDS5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MCI2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCI2/entry", "sequence": { "sequence": "MATPGSEPQPFVSALSVATLHPHHHPHHHHHHHGGTGASGGAAGGGGGGGGGGGGGFNLPLNRGLERALEEAANSGGLNLSARKLKEFPRTAAPAHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIINLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTTDSLYLHTMERPHLHQQVEDGKKDSDSGVGSDNGDKRLSATEPSDEDAVSLNVPMSNIMEEEQMKEDSCHRLSPVQGGFHQEFQPAPSLVSDSDNSGEDRGQFSHGKDVIHSEFINYMKEKTEACEELLRIEEDAHWPSEGTISASKDQDLDIAMIEQLREAVDLLQDPSRLSTDITERSVVNFYPVDPADDLELQDSTLNGQIQLERSPECEAQNDLTLQSNGSEYSPNEMRENSPASSPTNTSTALFGLKPRSVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDGVVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEEKLCLPHHILEEKGLVKVGITVQALLDVTVAKALFT", "length": 698, "header": "tr|A0A3Q1MCI2-1|F1MDS5_BOVIN Computationally mapped isoform of Leucine rich repeats and calponin homology domain containing 1 OS=Bos taurus OX=9913 GN=LRCH1 PE=4 SV=1 CANONICAL=F1MDS5-1" }, "locus": { "chromosome": "12", "start_pos": 16705781, "end_pos": 16492884, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067507.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067507.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068059.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068059.1" } ] } }, { "isoform_ac": "F1MDS5-1", "url": "https://www.uniprot.org/uniprotkb/F1MDS5/entry", "sequence": { "sequence": "MATPGSEPQPFVSALSVATLHPHHHPHHHHHHHGGTGASGGAAGGGGGGGGGGGGGFNLPLNRGLERALEEAANSGGLNLSARKLKEFPRTAAPAHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIINLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTTDSLYLHTMERPHLHQQVEDGKKDSDSGVGSDNGDKRLSATEPSDEDAVSLNVPMSNIMEEEQMKEDSCHRLSPVQGGFHQEFQPAPSLVSDSDNSGEDRGQFSHGKDVIHSEFINYMKEKTEACEELLRIEEDAHWPSEGTISASKDQDLDIAMIEQLREAVDLLQDPSRLSTDITERSVVNFYPVDPADDLELQDSTLNGQIQLERSPECEAQNDLTLQSNGSEYSPNEMRENSPASSPTNTSTALFGLKPRSDPALTLPPISFNKLTQAQTWDSSSYCVPSAGDSDNVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDGVVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEADLCSPYDILQLDFRHIRKTVDTLLALGEKPPQPTSALRSRDLISFCLVHILFIVLIYITYRWNALPP", "length": 765, "header": "tr|F1MDS5-1|F1MDS5_BOVIN Isoform 1 of Leucine rich repeats and calponin homology domain containing 1 OS=Bos taurus OX=9913 GN=LRCH1 PE=4 SV=3 CANONICAL=F1MDS5-1" }, "locus": { "chromosome": "12", "start_pos": 16697011, "end_pos": 16492884, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003856.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003856.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003856.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003856.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3, "start_aa": "Thr", "end_pos": 3, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 732, "start_aa": "Thr", "end_pos": 732, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr732", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8M9QG10-1", "protein_name": "Leucine-rich repeat and calponin homology domain-containing protein 1 isoform X1", "gene_name": "lrch1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MATLGPEPRPLSQLPSAALQTNLSGLGSSTNLPLNRGLERALEDAANSGFLNLSTRKLKEFPRTASNYDLTDTVEADLSKNRLIDVPSEVCHLVSLETLNLYHNCIKSIPDTIISLQSLTCLNISRNQLSVLPACVCGLPLRVLNASNNKLNALPESIGQLTNLMELDVSCNEITALPRQIVQLKSLRELNVHRNLLCVLPEDLADLPLVKFDFCCNKVSTIPVCYRKMTQLQSLQLENNPLQSPPAQICMKGKIHIFKYLAMEACRSDKMADALYLPVTDRLSLTRPSNGSTEDIDQHKKLDSDSGVGSDNGDKRLSATEPSDEDSLSLNVPMTNITEEEGLSKDDSSEHISGLTGDRSSSESLKDHLSYRDSALSSPFVNYIKGRGADFDEPLRIEEDTNWVSEQTAKVNMINQLKEAVEMLQDPNRVNMNSADLSGIKLYPVEMVAVDDSLNGQESDEGQATPKAPGECWEFQRKRQFILERARLEAQLACQQYALHMAQQGDVIGQEGAGDSCENQITMNEEKTPVSSPTLNSPPFGLKPRSASPSVPCSTPPCPLPLTQAPPTDRDTPPSPAEGDMPSSVFFRTHKTLESVDPQFTMRRKMEQLREELELTEQLRESIESRLKVVLPEDLGCSLSDGVVLCHLVNHIRPRSVGSIHVPSPAVPKLSMAKCRRNVENFLDACRKMGVPESSLCSAYDVLQCNLRPLWAVVAALLMVESTGTRHMEGKVEGGREKETEVKKLIPESTQTPPPSWQIWDLIGSSLLHVFCLVMLFVAYSWSEFK", "length": 786 }, "evidence": [ { "id": "F1MDS5", "url": "https://omabrowser.org/oma/group/F1MDS5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F7FCE7-1", "protein_name": "Leucine rich repeats and calponin homology domain containing 1", "gene_name": "Lrch1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATPGSEPQAFAPALSVTALHPHIHQHHQHHGSTGSAGFNLPLNRGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTHLNLSRNQLSALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPPELVDLPLVKFDFSCNKVLVIPVCFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHSIERPHSHQHVEDSKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIAEEDQTTKEDACHRLAPAEGDFQPTPSLLGDSGSSGQEREQFAGRADVLHCELMNYIKDQAEDCEELLRIEEDAHWQTEELLNSSKDQDLDIVMIEQLREAEDLLQGPNGLTTDITERSILNLYPMCSAEALEFPDSSLNGQLQLERSPEREVQNDVTLQSNGSQCSPNEIREDSPSGSPTANITAPFGLKPRSDPALILPPVSFNKLTQAQTWDSSSYSVPSEGDSDNVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEADLCSPYDILLLDFRHIRKTVDTLLALGEKPPQSTSALRSRDLIGFCLIHVLLTVLVLIAYRWNALSA", "length": 744 }, "evidence": [ { "id": "F1MDS5", "url": "https://omabrowser.org/oma/group/F1MDS5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P62046-1", "protein_name": "Leucine-rich repeat and calponin homology domain-containing protein 1", "gene_name": "Lrch1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATPGSEPQAFAPALSVTALHPHLHQHHQHHQHHQHHGGTGGTGFNLPLNRGLERALEEAANSGGLNLSARKLKEFPRTTAPGHDLSDTVRADLSKNRLVEVPMELCQFVSLEILNLYHNCIRVIPEAIVNLQMLTHLNLSRNQLSALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPPELVDLPLVKFDFSCNKVLVIPVCFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTSDSLYLPTIERPHLHQHVEDSKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNAPMSNIVEEDQTIKEDACHRLTPTKGEFQPKPSILGDSGISGQEREQLAGRADARHSGLMNYIKDQAEDCEELLRIEEDAHWHMEELLNSSKDRELDIAMIEQLREAELLQDPNGLSADIIERSILNLFPMDSGEASEFPDPSLNGQLQLETSPDREVQNDLMLQSNGSQYSPNEIRENSPSVSPTANITAPFGLKPRSGSWCPEEVQGSLQAESSPRRPQLLSRHVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVTLHEDLGAALMDGVVLCHLANHVRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEEKLCLPHHILEEKGLVKVGTTVQALLDVTVTKALFT", "length": 709 }, "evidence": [ { "id": "F1MDS5", "url": "https://omabrowser.org/oma/group/F1MDS5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y2L9-1", "protein_name": "Leucine-rich repeat and calponin homology domain-containing protein 1", "gene_name": "LRCH1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATPGSEPQPFVPALSVATLHPLHHPHHHHHHHQHHGGTGAPGGAGGGGGGSGGFNLPLNRGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLSLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQIIKEDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAEDCEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNLYPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRENSPAVSPTTNSTAPFGLKPRSVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDGVVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEADLCSPCDILQLDFRHIRKTVDTLLALGEKAPPPTSALRSRDLIGFCLVHILFIVLVYITYHWNALSA", "length": 728 }, "evidence": [ { "id": "F1MDS5", "url": "https://omabrowser.org/oma/group/F1MDS5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cellular response to chemokine", "id": "GO:1990869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990869", "evidence": [ { "database": "UniProtKB", "id": "F1MDS5", "url": "https://www.uniprot.org/uniprotkb/F1MDS5" } ], "pmid": "" }, { "name": "negative regulation of T cell migration", "id": "GO:2000405", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000405", "evidence": [ { "database": "UniProtKB", "id": "F1MDS5", "url": "https://www.uniprot.org/uniprotkb/F1MDS5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MDS5", "url": "https://www.uniprot.org/uniprotkb/F1MDS5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 151, "end_pos": 153, "annotation": "n_glycosylation_sequon" }, { "start_pos": 521, "end_pos": 523, "annotation": "n_glycosylation_sequon" }, { "start_pos": 541, "end_pos": 543, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MDS5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 765, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MDS5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MDS5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MDS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS5" }, { "id": "PS50021", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50021" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calponin-homology (CH)", "eco_id": "ECO_0000259", "start_pos": 613, "end_pos": 729, "start_aa": "Met", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 3, 732 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 151, "end_pos": 153 }, { "start_pos": 521, "end_pos": 523 }, { "start_pos": 541, "end_pos": 543 }, { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MFS4-1", "uniprot_ac": "F1MFS4", "uniprot_id": "F1MFS4_BOVIN", "mass": { "chemical_mass": 124024.0, "monoisotopic_mass": 124024.0 }, "refseq": { "ac": "NP_001192597", "name": "SLIT-ROBO Rho GTPase-activating protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192597" }, "gene_names": [ { "name": "SRGAP1", "type": "recommended", "evidence": [ { "id": "F1MFS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFS4" } ] }, { "name": "SRGAP1", "type": "synonym", "evidence": [ { "id": "NP_001192597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192597" } ] } ], "protein_names": [ { "name": "SLIT-ROBO Rho GTPase-activating protein 1", "type": "recommended", "evidence": [ { "id": "F1MFS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFS4/entry#names_and_taxonomy" } ] }, { "name": "Rho GTPase-activating protein 13", "type": "synonym", "evidence": [ { "id": "F1MFS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFS4/entry#names_and_taxonomy" } ] }, { "name": "SLIT-ROBO Rho GTPase-activating protein 1", "type": "synonym", "evidence": [ { "id": "NP_001192597", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192597" } ] } ], "function": [ { "annotation": "GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.", "evidence": [ { "database": "UniProtKB", "id": "F1MFS4", "url": "https://www.uniprot.org/uniprotkb/F1MFS4#function" }, { "database": "UniProtKB", "id": "ARBA00056458", "url": "https://www.uniprot.org/uniprotkb/ARBA00056458#function" }, { "database": "UniProtKB", "id": "A0A3Q1MCM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCM9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFS4", "url": "https://www.uniprot.org/uniprotkb/F1MFS4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SRGAP1", "url": "https://www.uniprot.org/uniprotkb/F1MFS4", "locus": { "chromosome": "5", "start_pos": 49582507, "end_pos": 49889557, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011892", "url": "https://www.ensembl.org/id/ENSBTAG00000011892" } ] } } ], "crossref": [ { "id": "F1MFS4", "url": "https://alphafold.ebi.ac.uk/entry/F1MFS4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011892", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011892", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04383", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04383", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07683", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07683", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11955", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11955", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539452", "url": "https://www.ncbi.nlm.nih.gov/gene/539452", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035648", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035648", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037451", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037451", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:539452", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539452", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CPVHQPH", "url": "https://omabrowser.org/oma/group/CPVHQPH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCM9", "url": "https://www.orthodb.org/?gene=A0A3Q1MCM9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MFS4", "url": "https://www.orthodb.org/?gene=F1MFS4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14166", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14166", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00611", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00611", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192597", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCM9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCM9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFS4", "url": "https://www.uniprot.org/uniprotkb/F1MFS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFS4-1", "url": "https://www.uniprot.org/uniprotkb/F1MFS4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETDYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNAKLFNGDLETFIKDSGQIIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNRDINSVAGVLKLYFRGLENPLFPKERFNDLISCVRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIVKTIIIHHETIFPDAKELDGPVYEKCMAGDEYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGVDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRHPDGYLARQRKRGEPPPPARRPGRTSDGHCPLHPPHGLSNSSIDLGSPSLGSHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYSGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHSVALRSSEPQIRRSTSSSSDTLSTFKPAVAPRMGVQLKPPALRPKPAVLPKTNPTVGPAPPSQGPADKSCTM", "length": 1085, "header": "tr|F1MFS4-1|F1MFS4_BOVIN Isoform 1 of SLIT-ROBO Rho GTPase-activating protein 1 OS=Bos taurus OX=9913 GN=SRGAP1 PE=4 SV=3 CANONICAL=F1MFS4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MCM9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCM9/entry", "sequence": { "sequence": "MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETDYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTSRGRRNSHARHQDSGQIIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNRDINSVAGVLKLYFRGLENPLFPKERFNDLISCVRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIVKTIIIHHETIFPDAKELDGPVYEKCMAGDEYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGVDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRHPDGYLARQRKRGEPPPPARRPGRTSDGHCPLHPPHGLSNSSIDLGSPSLGSHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYSGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHSVALRSSEPQIRRSTSSSSDTLSTFKPAVAPRMGVQLKPPALRPKPAVLPKTNPTVGPAPPSQGPADKSCTM", "length": 1062, "header": "tr|A0A3Q1MCM9-1|F1MFS4_BOVIN Computationally mapped isoform of SLIT-ROBO Rho GTPase-activating protein 1 OS=Bos taurus OX=9913 GN=SRGAP1 PE=4 SV=1 CANONICAL=F1MFS4-1" }, "locus": { "chromosome": "5", "start_pos": 49889515, "end_pos": 49582755, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072463.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072463.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071878.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071878.1" } ] } }, { "isoform_ac": "F1MFS4-1", "url": "https://www.uniprot.org/uniprotkb/F1MFS4/entry", "sequence": { "sequence": "MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETDYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNAKLFNGDLETFIKDSGQIIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNRDINSVAGVLKLYFRGLENPLFPKERFNDLISCVRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIVKTIIIHHETIFPDAKELDGPVYEKCMAGDEYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGVDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRHPDGYLARQRKRGEPPPPARRPGRTSDGHCPLHPPHGLSNSSIDLGSPSLGSHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYSGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHSVALRSSEPQIRRSTSSSSDTLSTFKPAVAPRMGVQLKPPALRPKPAVLPKTNPTVGPAPPSQGPADKSCTM", "length": 1085, "header": "tr|F1MFS4-1|F1MFS4_BOVIN Isoform 1 of SLIT-ROBO Rho GTPase-activating protein 1 OS=Bos taurus OX=9913 GN=SRGAP1 PE=4 SV=3 CANONICAL=F1MFS4-1" }, "locus": { "chromosome": "5", "start_pos": 49889515, "end_pos": 49582755, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015786.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015786.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015786.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015786.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1001, "start_aa": "Thr", "end_pos": 1001, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1001", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:539452", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539452", "resource": "KEGG Pathway" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M6Z228-1", "protein_name": "SLIT-ROBO Rho GTPase-activating protein 1", "gene_name": "srgap1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLKMSNPPVKFKKDKEIIVEYETQVKEIRAQLVEQQKCLEQQTDMRVQLLQDLQDFFRKKSEIEMEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRLMKKSKEITFQLQEDLMKVLNELYTVMKTYHMYHTESISAEGKLKEAEKQEEKQIGRVGDPVFHIRLEDRHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASIFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDSLDPRSDRQRFMEMYPTAFCPPVKFEFQAHMGDEVCQITAQPPVQAELLLRFQQLQSRLTTLKIENEEIKKTSEATLTTIQDMVTVEDYDVSECFHHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKFREYLEGSNLITKLQAKHDLLKRTLGDGYRPEYATTRPPSLPPKPFGTQRARPRSVFNVKLFNGNLESFVKDSGQAIPRVVESCIRFINLYGLQHQGIFRVPGSQVEVNDIKNSFERGNDPLTDEENNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIENLYERALYIRKILLTAPRSVLVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPTPETQDQVSCQAHVNEVIKTIIIHHETIFPDSKELDGPLYEKCMAGGDYCESPYSEHGALEEVDQDGGAETHTSEDEGEPIEAIAKFDYVGRSARELSFKKGASLLLYQRASDDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGHGGEEKCSSRDMGSPTDSRLPDAYISRHRKRSDPPTRRPPARPTDTHCLVHPSHHSSHTNPDLGSPVMGHYSPRDMLRGRGHMPMDSPERRRRTGHGSLTNISRHESIKKMESPPIRRSTSSGQYSSFNEPHVKSLDPESIAQDIEETMNTALNELKELERQSSAKHAPDVVLDTLEQMKNAPTPASSTESLSQLHGLLLRPAGTELHMRRSTSSSSDTMSTFKPAVAPRMGVQLKPPTLRPKPMVPVPKTGAAQHPAAPPQDPLDKSCTM", "length": 1096 }, "evidence": [ { "id": "F1MFS4", "url": "https://omabrowser.org/oma/group/F1MFS4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1M287-1", "protein_name": "SLIT-ROBO Rho GTPase-activating protein 1", "gene_name": "Srgap1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQQFKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHSESISAESKLKEAEKQEEKQMGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRNQQLQSRLATLKIESEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREFLEGSSLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNAKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIHKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIVKTIIIHHETIFPDAKELDGPVYEKCMAGGDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVPEDKSSSKDMNSPTDRHSDSYLARQRKRGEPPPPGRRPGRTSDGHCPLHPPHALSNSSIDLGSPNLTGHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTVKHAPDVVLDTLEQVKNSPTPATSTESLSPLHSVTLRSSEPQLRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPAVLPKTNPTVGPAAPSQGPTDKSCTM", "length": 1085 }, "evidence": [ { "id": "F1MFS4", "url": "https://omabrowser.org/oma/group/F1MFS4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7Z6B7-1", "protein_name": "SLIT-ROBO Rho GTPase-activating protein 1", "gene_name": "SRGAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRHPDGYLARQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSSEPQIRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPAVLPKTNPTIGPAPPPQGPTDKSCTM", "length": 1085 }, "evidence": [ { "id": "F1MFS4", "url": "https://omabrowser.org/oma/group/F1MFS4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91Z69-1", "protein_name": "SLIT-ROBO Rho GTPase-activating protein 1", "gene_name": "Srgap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQQFKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHSESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRNQQLQSRLATLKIESEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREFLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTSRGRRNSHARHQDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLSDEQSNHDINSVAGVLKLYFRGLENPLFPKERFTDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIVKTIIIHHETIFPDAKELDGPVYEKCMAGGDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRHSDSYLARQRKRGEPPPPGRRPGRTSDGHCPLHPPHALSNSSIDLGSPNLASHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTVKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRGSEPQIRRSTSSSSETMSTFKPMVAPRMGVQLKPPALRPKPAVLPKTNPTMGPAAPSQGPTDKSCTM", "length": 1062 }, "evidence": [ { "id": "F1MFS4", "url": "https://omabrowser.org/oma/group/F1MFS4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "F1MFS4", "url": "https://www.uniprot.org/uniprotkb/F1MFS4" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "F1MFS4", "url": "https://www.uniprot.org/uniprotkb/F1MFS4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1MFS4", "url": "https://www.uniprot.org/uniprotkb/F1MFS4" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "F1MFS4", "url": "https://www.uniprot.org/uniprotkb/F1MFS4" } ], "pmid": "" }, { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "F1MFS4", "url": "https://www.uniprot.org/uniprotkb/F1MFS4" } ], "pmid": "" }, { "name": "regulation of synapse assembly", "id": "GO:0051963", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051963", "evidence": [ { "database": "UniProtKB", "id": "F1MFS4", "url": "https://www.uniprot.org/uniprotkb/F1MFS4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 879, "end_pos": 881, "annotation": "n_glycosylation_sequon" }, { "start_pos": 904, "end_pos": 906, "annotation": "n_glycosylation_sequon" }, { "start_pos": 920, "end_pos": 922, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MFS4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1085, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MFS4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MFS4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFS4" }, { "id": "PS51741", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51741" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F-BAR", "eco_id": "ECO_0000259", "start_pos": 19, "end_pos": 314, "start_aa": "Ser", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MFS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFS4" }, { "id": "PS50238", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50238" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rho-GAP", "eco_id": "ECO_0000259", "start_pos": 506, "end_pos": 694, "start_aa": "Gly", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MFS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFS4" }, { "id": "PS50002", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50002" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SH3", "eco_id": "ECO_0000259", "start_pos": 743, "end_pos": 802, "start_aa": "Cys", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1001 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 251, "end_pos": 253 }, { "start_pos": 879, "end_pos": 881 }, { "start_pos": 904, "end_pos": 906 }, { "start_pos": 920, "end_pos": 922 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], 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"tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MCN4-1", "uniprot_ac": "F1MCN4", "uniprot_id": "F1MCN4_BOVIN", "mass": { "chemical_mass": 127073.0, "monoisotopic_mass": 127073.0 }, "refseq": { "ac": "XP_005213724", "name": "stAR-related lipid transfer protein 13 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213724" }, "gene_names": [ { "name": "STARD13", "type": "recommended", "evidence": [ { "id": "F1MCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCN4" } ] }, { "name": "STARD13", "type": "synonym", "evidence": [ { "id": "XP_005213724", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213724" } ] } ], "protein_names": [ { "name": "StAR-related lipid transfer protein 13", "type": "recommended", "evidence": [ { "id": "F1MCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCN4/entry#names_and_taxonomy" } ] }, { "name": "Deleted in liver cancer 1 protein 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"https://www.uniprot.org/uniprotkb/F1MCN4", "locus": { "chromosome": "12", "start_pos": 28012399, "end_pos": 27520069, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021815", "url": "https://www.ensembl.org/id/ENSBTAG00000021815" } ] } } ], "crossref": [ { "id": "F1MCN4", "url": "https://alphafold.ebi.ac.uk/entry/F1MCN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021815", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021815", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04375", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04375", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08909", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08909", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09592", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09592", "database": "CDD", 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538697", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538697", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CVNAMST", "url": "https://omabrowser.org/oma/group/CVNAMST/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12659", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12659", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12659:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12659:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01852", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01852", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07647", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07647", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005213724", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213724", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDL7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDL7-1", "database": 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"url": "https://www.uniprot.org/uniprotkb/F1MCN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"length": 1108, "header": "tr|A0A3Q1MDL7-1|F1MCN4_BOVIN Computationally mapped isoform of StAR-related lipid transfer protein 13 OS=Bos taurus OX=9913 GN=STARD13 PE=4 SV=1 CANONICAL=F1MCN4-1" }, "locus": { "chromosome": "12", "start_pos": 28011188, "end_pos": 27785642, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067678.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067678.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066929.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066929.1" } ] } }, { "isoform_ac": "A0AAA9S3E7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3E7/entry", "sequence": { "sequence": "MVLSDKRSKERAEIEAKEACDWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDLVEPLYRRLNTLNKCASMKLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLHTLFPGGDRNGSSGDIRMKNTTSSESVLTDLSEPEVCSIHSESSGGSDGRSQPGGHGVGREAFEGPGQYCVDGPVMLDAALVGNSLLPSSKDGLQHPLHPKNEKPSRARAKSFLKRMETLRGKGAQGRHKGRPGGLVISGPVLQQEPESFRAMQCVQIPNGHLQNSPPATGSAGLPGATKWGAESSPSENSSSGGSTPGLKERKCQEAHKRGGMYLEDLDVLAGTALQDAGDRKHHAHEFHSQENLVVHVPKDHKPGTFPKALSIESLSPTDNSHGASWRTGSISLGRQPGPGAREPRLVGSCHRASRVSIYDNVPGSHLYASTGDLLDLEKDDLFPHLDDILHHVNGLQEVVDDWSRNVLPEPQTHSSGEAGFSPFPSPNQITLDFEGNSVSEGRTTPSDMERDGASLTESEATGVRERRDSGVGASLTRPNRRLRWNSFQLSHQPQPSTASPHISGQTAGQLNLLQRFSLLRLTAIMEKHSMSNKHGWTWAVPKFMKRMKVPDYRDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPENVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAVLLLADESREVLQTLLCFLNDVVHAVEENQMTPMNLAVCLAPSLFHLNLLKKESSPRVIQKKYAAGKPDQKDLSENLAAAQGLAHMIMECDRLFEVPLEMVAQSHNSYVEAEIHPPTLEELGAQLEDSGATFHTYLEHLVQGLQKEAKEKFKGWVTCPSTDSTELAFKKVGDGPPLRLWKASAEVEAPPSVVLNRVLRERHLWDEDFVQWKVVETLDKQTEVYQYVLNSMAPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLMGGVRAAVMDSQYLIEPCGSGKSRLTHICRVDLRGHSPEWYNKGFGHLCAAEVARIRNSFQPLIAEGPETKI", "length": 1079, "header": "tr|A0AAA9S3E7-1|F1MCN4_BOVIN Computationally mapped isoform of StAR-related lipid transfer protein 13 OS=Bos taurus OX=9913 GN=STARD13 PE=4 SV=1 CANONICAL=F1MCN4-1" }, "locus": { "chromosome": "12", "start_pos": 28011188, "end_pos": 27624116, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106344.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106344.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079628.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079628.1" } ] } }, { "isoform_ac": "A0AAA9S968-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S968/entry", "sequence": { "sequence": "MSTGARPKTQVLSDKRSKERAEIEAKEACDWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDLVEPLYRRLNTLNKCASMKLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLHTLFPGGDRNGSSGDIRMKNTTSSESVLTDLSEPEVCSIHSESSGGSDGRSQPGGHGVGREAFEGPGQYCVDGPVMLDAALVGNSLLPSSKDGLQHPLHPKNEKPSRARAKSFLKRMETLRGKGAQGRHKGRPGGLVISGPVLQQEPESFRAMQCVQIPNGHLQNSPPATGSAGLPGATKWGAESSPSENSSSGGSTPGLKERKCQEAHKRGGMYLEDLDVLAGTALQDAGDRKHHAHEFHSQENLVVHVPKDHKPGTFPKALSIESLSPTDNSHGASWRTGSISLGRQPGPGAREPRLVGSCHRASRVSIYDNVPGSHLYASTGDLLDLEKDDLFPHLDDILHHVNGLQEVVDDWSRNVLPEPQTHSSGEAGFSPFPSPNQITLDFEGNSVSEGRTTPSDMERDGASLTESEATGVRERRDSGVGASLTRPNRRLRWNSFQLSHQPQPSTASPHISGQTAGQLNLLQRFSLLRLTAIMEKHSMSNKHGWTWAVPKFMKRMKVPDYRDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPENVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAVLLLADESREVLQTLLCFLNDVVHAVEENQMTPMNLAVCLAPSLFHLNLLKKESSPRVIQKKYAAGKPDQKDLSENLAAAQGLAHMIMECDRLFEVPLEMVAQSHNSYVEAEIHPPTLEELGAQLEDSGATFHTYLEHLVQGLQKEAKEKFKGWVTCPSTDSTELAFKKVGDGPPLRLWKASAEVEAPPSVVLNRVLRERHLWDEDFVQWKVVETLDKQTEVYQYVLNSMAPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLMGGVRAAVMDSQYLIEPCGSGKSRLTHICRVDLRGHSPEWYNKGFGHLCAAEVARIRNSFQPLIAEGPETKI", "length": 1088, "header": "tr|A0AAA9S968-1|F1MCN4_BOVIN Computationally mapped isoform of StAR-related lipid transfer protein 13 OS=Bos taurus OX=9913 GN=STARD13 PE=4 SV=1 CANONICAL=F1MCN4-1" }, "locus": { "chromosome": "12", "start_pos": 28011188, "end_pos": 27647210, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132123.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132123.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079928.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079928.1" } ] } }, { "isoform_ac": "A0AAA9SKL2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKL2/entry", "sequence": { "sequence": "MSTGARPKTQVLSDKRSKERAGCFTLFGKKEERLYEIEAKEACDWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDLVEPLYRRLNTLNKCASMKLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLHTLFPGGDRNGSSGDIRMKNTTSSESVLTDLSEPEVCSIHSESSGGSDGRSQPGGHGVGREAFEGPGQYCVDGPVMLDAALVGNSLLPSSKDGLQHPLHPKNEKPSRARAKSFLKRMETLRGKGAQGRHKGRPGGLVISGPVLQQEPESFRAMQCVQIPNGHLQNSPPATGSAGLPGATKWGAESSPSENSSSGGSTPGLKERKCQEAHKRGGMYLEDLDVLAGTALQDAGDRKHHAHEFHSQENLVVHVPKDHKPGTFPKALSIESLSPTDNSHGASWRTGSISLGRQPGPGAREPRLVGSCHRASRVSIYDNVPGSHLYASTGDLLDLEKDDLFPHLDDILHHVNGLQEVVDDWSRNVLPEPQTHSSGEAGFSPFPSPNQITLDFEGNSVSEGRTTPSDMERDGASLTESEATGVRERRDSGVGASLTRPNRRLRWNSFQLSHQPQPSTASPHISGQTAGQLNLLQRFSLLRLTAIMEKHSMSNKHGWTCLSPQCAPRGVHDLVSVNSRAVPKFMKRMKVPDYRDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPENVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAVLLLADESREVLQTLLCFLNDVVHAVEENQMTPMNLAVCLAPSLFHLNLLKKESSPRVIQKKYAAGKPDQKDLSENLAAAQGLAHMIMECDRLFEVPLEMVAQSHNSYVEAEIHPPTLEELGAQLEDSGATFHTYLEHLVQGLQKEAKEKFKGWVTCPSTDSTELAFKKVGDGPPLRLWKASAEVEAPPSVVLNRVLRERHLWDEDFVQWKVVETLDKQTEVYQYVLNSMAPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLMGGVRAAVMDSQYLIEPCGSGKSRLTHICRVDLRGHSPEWYNKGFGHLCAAEVARIRNSFQPLIAEGPETKI", "length": 1121, "header": "tr|A0AAA9SKL2-1|F1MCN4_BOVIN Computationally mapped isoform of StAR-related lipid transfer protein 13 OS=Bos taurus OX=9913 GN=STARD13 PE=4 SV=1 CANONICAL=F1MCN4-1" }, "locus": { "chromosome": "12", "start_pos": 28011188, "end_pos": 27647210, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088023.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088023.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084453.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084453.1" } ] } }, { "isoform_ac": "F1MCN4-1", "url": "https://www.uniprot.org/uniprotkb/F1MCN4/entry", "sequence": { "sequence": "MLSQGPRTPASGCYYLNAMTPEGQEMYLRFDQTTRRSPYRMSRILARHQLVTKIQQEIEAKEACDWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDLVEPLYRRLNTLNKCASMKLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLHTLFPGGDRNGSSGDIRMKNTTSSESVLTDLSEPEVCSIHSESSGGSDGRSQPGGHGVGREAFEGPGQYCVDGPVMLDAALVGNSLLPSSKDGLQHPLHPKNEKPSRARAKSFLKRMETLRGKGAQGRHKGRPGGLVISGPVLQQEPESFRAMQCVQIPNGHLQNSPPATGSAGLPGATKWGAESSPSENSSSGGSTPGLKERKCQEAHKRGGMYLEDLDVLAGTALQDAGDRKHHAHEFHSQENLVVHVPKDHKPGTFPKALSIESLSPTDNSHGASWRTGSISLGRQPGPGAREPRLVGSCHRASRVSIYDNVPGSHLYASTGDLLDLEKDDLFPHLDDILHHVNGLQEVVDDWSRNVLPEPQTHSSGEAGFSPFPSPNQITLDFEGNSVSEGRTTPSDMERDGASLTESEATGVRERRDSGVGASLTRPNRRLRWNSFQLSHQPQPSTASPHISGQTAGQLNLLQRFSLLRLTAIMEKHSMSNKHGWTCLSPQCAPRGVHDLVSVNSRAVPKFMKRMKVPDYRDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPENVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAVLLLADESREVLQTLLCFLNDVVHAVEENQMTPMNLAVCLAPSLFHLNLLKKESSPRVIQKKYAAGKPDQKDLSENLAAAQGLAHMIMECDRLFEVPLEMVAQSHNSYVEAEIHPPTLEELGAQLEDSGATFHTYLEHLVQGLQKEAKEKFKGWVTCPSTDSTELAFKKVGDGPPLRLWKASAEVEAPPSVVLNRVLRERHLWDEDFVQWKVVETLDKQTEVYQYVLNSMAPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLMGGVRAAVMDSQYLIEPCGSGKSRLTHICRVDLRGHSPEWYNKGFGHLCAAEVARIRNSFQPLIAEGPETKI", "length": 1142, "header": "tr|F1MCN4-1|F1MCN4_BOVIN Isoform 1 of StAR-related lipid transfer protein 13 OS=Bos taurus OX=9913 GN=STARD13 PE=4 SV=4 CANONICAL=F1MCN4-1" }, "locus": { "chromosome": "12", "start_pos": 28011188, "end_pos": 27845170, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029081.8", "url": "https://www.ensembl.org/id/ENSBTAT00000029081.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029081.7", "url": "https://www.ensembl.org/id/ENSBTAP00000029081.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 356, "start_aa": "Thr", "end_pos": 356, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr356", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538697", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538697", "resource": "KEGG Pathway" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013106", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "resource": "Reactome", "description": "RHOC GTPase cycle" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7JLP2-1", "protein_name": "StAR-related lipid transfer protein 13", "gene_name": "Stard13", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MFSQVPRTPAAGCYYLNPMTPESQEMYLRFDQTARRSPYRTSRILARQHLVTKIQQEIEAKEACDWLRAAGFPQYAQLYEDSQFPINIVAVKKDHDFLERDLVETLCRRLNTLNKCASMRLDVNFLRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLHTLFPGADRNGSPGGPRMRNTTSSESVLTDLSEPEVCSIHSESSGGSDSRSQSGHQCADNTLVLEGTQVSSSLPQSPRDSLSYPSHPKNEKPARARAKSFLKRMDTLRTKGAHGRHKGSGRTGGLVISGPVLQQEPESFKAMQHVQMPNGDVQTSPPAACRKGLPCSRKSSGESSPLENSSRVSTPCTKERKCHHEANKRGGMYLEDLDVLAGTELPDTWDQNHKHGFHSQENLVVHIPKDHKPGTFPKALSIESLSPTDNSNGVNWRTGGISLGRQQGPGMREPRLMASCHRASRVSIYDNVPGSHLYASTGDLLDLEKDGLLPQLDAILQHVNGIQEVVDDWSKHILPELQSHDVLTGEPGLSPFPSPNQITLDFEGNSVSEGRTTPSDVERDGTSLNESEAAGVKERRDSGVGASLTRPNRRLRWSSFQLSHQPQPSPATLHISSQTAAQLNLFQRFSLLRLTAIMEKCSMSNKHGWTCLSARCAPGALHDLVSVNSRSVPKFMKRMKVPDYKDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRILALRQMNENFPENVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVKENQMTPMNLAVCLAPSLFHLNLAKKESSPRVIQKKYATGKPDLKDLNDNQAAAQGLAHMITECNRLFEVPYEMVLQSRSSYLEAEIHTPSLEDLGTQLAESGATFHTYLEHLIQGLQKEAREKFKGWVTCPSPDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDEDFVQWKVVETLDRQTEIYQYVLNSMAPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLIGGVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVARIRNSFQPLIAEGPETKI", "length": 1132 }, "evidence": [ { "id": "F1MCN4", "url": "https://omabrowser.org/oma/group/F1MCN4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZU63-1", "protein_name": "StAR-related lipid transfer protein 13", "gene_name": "Stard13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFSQVPRTPAAGCYCLNPLTPESQEMYLRFDQTARRSPYRMSRILARHHLVTKIQQEIEAKEACDWLRAAGFPQYAQLYEDSQFPINIAAVKKDHDFLERDLVEPLCRRLNTLNKCASMRLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLHPLLPGADRNGSPGGPRMRNTASSESVLTDLSEPEVCSIHSESSGGSDGRGQSGHHFADGTPVLEGTLVGGSLPQSPRDSLSQSFHPKNEKPTRTRAKSFLRRMDTLRVKGALGRHKGPGRTGGLVISRPMLQQEPESFKTMQHVQIPNGDLQTSPPAACKKGLPGSSKSSGENSPLESSRVSTPCMKERKCQHEANKRGGMYLEDLDVLAGTTLPDTGDQNHIHGFHSQENLVVHVPKDHKPGTFPKALSIESLSPTDSSNGVNWRTGSISLGRQQGPGIREPRLVSSCHRASRVSIYDNVPSSHLYASTGDLLDLEKDGLLPQLDDIIQHVNGIQEVVDDWSRNILPELQSHDAVAGDPGQPPFQSPHQITLDFEGNSVSEGQTTPSDVERDRTSLNESDTTGVRERRDSGVGASLTRPNRRLRWSSFQLSHQPQLSPATPHISSQTAAQLNLLQRFSLLRLTAIMEKYSMSNKHGWTCLSAQSAPGALHDLVSVNSRSVPKFMKRIKAPDYRDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLFHLNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMITECNRLFEVPHEMVAQSRNSYLEAEIHAPSLEDLGTQLAENGATFHTYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDEDFVQWKVVETLDRQTEIYQYVLNSMVPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLMGDVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVARIRNSFQPLVAEGPETKI", "length": 1131 }, "evidence": [ { "id": "F1MCN4", "url": "https://omabrowser.org/oma/group/F1MCN4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q923Q2-1", "protein_name": "StAR-related lipid transfer protein 13", "gene_name": "Stard13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSQVPRTPAAGCYYLNPLTPESQEMYLRFDQTARRSPYRMSRILARHHLVTKIQQEIEAKEACDWLRAAGFPQYAQLYEDSQFPINIAAVKKDHDFLERDLVEPLCRRLNTLNKCASMRLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLHTLFPVADRNGSPGGPRMRNTASSESVLTDLSEPEVCSIHSESSGGSDSRSQSGHHSADSTHALEATLVSSSLPQSTREGLNQSFHPKNEKPTRTRAKSFLKRMDTLRVKGALGRHKGPGRTGGLVISRPVLQQEPESFKTMQCVQIPNGDLQTSPPAACRKGLPCSSKSSGESSPLENSSTVSTPCMKERKCHHEANKRGGMYLEDLDVLAGTALPDTSDQNHMHGFHSQENLVVHIPKDHKPGTFPKALSIESLSPTDNSNGVNWRTGSISLGRQQGPGMREPRLMSSCHRASRVSIYDNVPSSHLYASTGDLLDLEKDGLLPQLDDILQHVNGIQEVVDDWSKNILPELQSHSTLAGDPGLSPFPSPNQVTLDFEGNSVSEGRTTPSDVERDRTSLNESEATGVRERRDSGVGASLTRPNRRLRWSSFQLSHQPQPSPATPHISSQTAAQLNLLQRFSLLRLTAIMEKYSMSNKHGWTWSVPKFMKRIKAPDYRDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLFHLNLLKKESSPKVIQKKYATGKPDQKDLNENLAAAQGLAHMITECNRLFEVPHEMVAQSRDSYLEAEIHVPSLEDLGAQLAESGATFHTYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLAFKKVGDGHPLKLWKASVEVEAPPSVVLNRVLRERHLWDEDFVQWKVVERLDKQTEIYQYVLNSMVPHPSRDFLVLRTWKTDLPKGMCTLVSLSVEYEEAQLMGGVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVTRIRNSFQPLVAEGPETKI", "length": 1113 }, "evidence": [ { "id": "F1MCN4", "url": "https://omabrowser.org/oma/group/F1MCN4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y3M8-1", "protein_name": "StAR-related lipid transfer protein 13", "gene_name": "STARD13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFSQVPRTPASGCYYLNSMTPEGQEMYLRFDQTTRRSPYRMSRILARHQLVTKIQQEIEAKEACDWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDLVEPLCRRLNTLNKCASMKLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLYTLLPRGDRNGSPGGTGMRNTTSSESVLTDLSEPEVCSIHSESSGGSDSRSQPGQCCTDNPVMLDAPLVSSSLPQPPRDVLNHPFHPKNEKPTRARAKSFLKRMETLRGKGAHGRHKGSGRTGGLVISGPMLQQEPESFKAMQCIQIPNGDLQNSPPPACRKGLPCSGKSSGESSPSEHSSSGVSTPCLKERKCHEANKRGGMYLEDLDVLAGTALPDAGDQSRMHEFHSQENLVVHIPKDHKPGTFPKALSIESLSPTDSSNGVNWRTGSISLGREQVPGAREPRLMASCHRASRVSIYDNVPGSHLYASTGDLLDLEKDDLFPHLDDILQHVNGLQEVVDDWSKDVLPELQTHDTLVGEPGLSTFPSPNQITLDFEGNSVSEGRTTPSDVERDVTSLNESEPPGVRDRRDSGVGASLTRPNRRLRWNSFQLSHQPRPAPASPHISSQTASQLSLLQRFSLLRLTAIMEKHSMSNKHGWTWSVPKFMKRMKVPDYKDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPENVNYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPSLFHLNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMIMECDRLFEVPHELVAQSRNSYVEAEIHVPTLEELGTQLEESGATFHTYLNHLIQGLQKEAKEKFKGWVTCSSTDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDEDFVQWKVVETLDRQTEIYQYVLNSMAPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLLGGVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVARIRNSFQPLIAEGPETKI", "length": 1113 }, "evidence": [ { "id": "F1MCN4", "url": "https://omabrowser.org/oma/group/F1MCN4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "F1MCN4", "url": "https://www.uniprot.org/uniprotkb/F1MCN4" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "F1MCN4", "url": "https://www.uniprot.org/uniprotkb/F1MCN4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "F1MCN4", "url": "https://www.uniprot.org/uniprotkb/F1MCN4" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "F1MCN4", "url": "https://www.uniprot.org/uniprotkb/F1MCN4" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MCN4", "url": "https://www.uniprot.org/uniprotkb/F1MCN4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1MCN4", "url": "https://www.uniprot.org/uniprotkb/F1MCN4" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "F1MCN4", "url": "https://www.uniprot.org/uniprotkb/F1MCN4" } ], "pmid": "" }, { "name": "regulation of Rho protein signal transduction", "id": "GO:0035023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035023", "evidence": [ { "database": "UniProtKB", "id": "F1MCN4", "url": "https://www.uniprot.org/uniprotkb/F1MCN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 749, "end_pos": 751, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MCN4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1142, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MCN4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MCN4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCN4" }, { "id": "PS50238", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50238" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rho-GAP", "eco_id": "ECO_0000259", "start_pos": 692, "end_pos": 897, "start_aa": "Val", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCN4" }, { "id": "PS50848", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50848" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "START", "eco_id": "ECO_0000259", "start_pos": 943, "end_pos": 1111, "start_aa": "Val", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 356 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 169, "end_pos": 171 }, { "start_pos": 179, "end_pos": 181 }, { "start_pos": 349, "end_pos": 351 }, { "start_pos": 749, "end_pos": 751 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MEL4-1", "uniprot_ac": "F1MEL4", "uniprot_id": "F1MEL4_BOVIN", "mass": { "chemical_mass": 68518.0, "monoisotopic_mass": 68518.0 }, "refseq": {}, "gene_names": [ { "name": "COIL", "type": "recommended", "evidence": [ { "id": "F1MEL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEL4" } ] } ], "protein_names": [ { "name": "Coilin", "type": "synonym", "evidence": [ { "id": "F1MEL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEL4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MEL4", "url": "https://www.uniprot.org/uniprotkb/F1MEL4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COIL", "url": "https://www.uniprot.org/uniprotkb/F1MEL4", "locus": { "chromosome": "19", "start_pos": 7765322, "end_pos": 7786904, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017275", "url": "https://www.ensembl.org/id/ENSBTAG00000017275" } ] } } ], "crossref": [ { "id": "F1MEL4", "url": "https://alphafold.ebi.ac.uk/entry/F1MEL4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017275", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017275", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR024822", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024822", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031722", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031722", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CEYKKQT", "url": "https://omabrowser.org/oma/group/CEYKKQT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MEJ5", "url": "https://www.orthodb.org/?gene=A0A3Q1MEJ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MEL4", "url": "https://www.orthodb.org/?gene=F1MEL4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15197", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15197", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15197:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15197:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15862", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15862", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23086", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23086", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MEJ5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ99", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZ99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ99-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEL4", "url": "https://www.uniprot.org/uniprotkb/F1MEL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEL4-1", "url": "https://www.uniprot.org/uniprotkb/F1MEL4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESTPLRVALQSSVAATPTNRGHSFIGSRGRAPSTPLGRPVESLGFRCASSKMAASETVRLRLQFDYPPPGAPHCTSFWLLIDLNGCRVVTDLISLIRQRFGFSSGALLGLYLEGALLPPAESARLVRDNDCLRVKLEERGIAESPVTVSNGDSIRLSPRKAKKRAFKLDEDEETELDYRNSKKHWKRHENNNSEKTLDLEPKATTDQSVSKKNKRKNKAMCDAVEVDDGETEKKLPKKKEKREYKKHAKTPKSSKAQSVKEWTIQKCSPKALPARNSLVKAKRKGGMVVRTKDSPDSSSESESYHESTSDGLSNVILEVRHSSEKISTDVSKEGSSVKTTAANKVAPKTGFTSVPVKGKTSRTSSSSSDSSSESDDQCVMPKSTPECTAEFLKTVGLFVGRNCPGPSSQAPNTAGWKQSDPNSGSRTQTVLCPPPNVTLPASLGRGWGRGEDLLSWKGARGRGMRGRGRGRGHAVPYVLNRNADYQKQQQLNEMVTNSSTIIQNPIETQKKDYSLLPLLAAAPQVGEKIAFKLLELTSNYSPDVSDYKEGRILSHNPETQQVDIEILSSLPAMKEPGKFDLVYHNENGAEVVEYAVTQEKRITVLWRELIDPRLIIESPSNT", "length": 623, "header": "tr|F1MEL4-1|F1MEL4_BOVIN Isoform 1 of Coilin OS=Bos taurus OX=9913 GN=COIL PE=4 SV=3 CANONICAL=F1MEL4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MEJ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEJ5/entry", "sequence": { "sequence": "MESTPLRVALQSSVAATPTNRGHSFIGSRGRAPSTPLGRPVESLGFRCASSKMAASETVRLRLQFDYPPPGAPHCTSFWLLIDLNGCRVVTDLISLIRQRFGFSSGALLGLYLEGALLPPAESARLVRDNDCLRVKLEERGIAESPVTVSNGDSIRLSPRKAKKRAFKLDEDEETELDYRNSKKHWKRHENNNSEKTLDLEPKATTDQSVSKKNKRKNKAMCDAVEVDDGETEKKLPKKKEKREYKKHAKTPKSSKAQSVKEWTIQKCSPKALPARNSLVKAKRKGGMVVRTKDSPDSSSESESYHESTSDGLSNVILEVRHSSEKISTDVSKEGSSVKTTAANKVAPKTGFTSVPVKGKTSRTSSSSSDSSSESDDQCVMPKSTPECTAEFLKTVGLFVGRNCPGPSSQAPNTAGWKQSDPNSGSRTQTVLCPPPNVTLPASLGRGWGRGEDLLSWKGARGRGMRGRGRGRGHAVPYVLNRNADYQKQQQLNEMVTNSSTIIQNPIETQKKDYSLLPLLAAAPQVGEKIAFKEGRILSHNPETQQVDIEILSSLPAMKEPGKFDLVYHNENGAEVVEYAVTQEKRITVLWRELIDPRLIIESPSNT", "length": 607, "header": "tr|A0A3Q1MEJ5-1|F1MEL4_BOVIN Computationally mapped isoform of Coilin OS=Bos taurus OX=9913 GN=COIL PE=4 SV=1 CANONICAL=F1MEL4-1" }, "locus": { "chromosome": "19", "start_pos": 7786808, "end_pos": 7766220, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083949.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083949.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069440.1", "url": "https://www.ensembl.org/id/ENSBTAP00000069440.1" } ] } }, { "isoform_ac": "A0AAA9SZ99-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZ99/entry", "sequence": { "sequence": "MESTPLRVALQSSVAATPTNRGHSFIGSRGRAPSTPLGRPVESLGFRCASSKMAASETVRLRLQFDYPPPGAPHCTSFWLLIDLNGCRVVTDLISLIRQRFGFSSGALLGLYLEGALLPPAESARLVRDNDCLRVKLEERGIAESPVTVSNGDSIRLSPRKAKKRAFKLDEDEETELDYRNSKKHWKRHENNNSEKTLDLEPKATTDQSVSKKNKRKNKAMCDAVEVDDGETEKKLPKKKEKREYKKHAKTPKSSKAQSVKEWTIQKCSPKALPARNSLVKAKRKGGMVVRTKDSPDSSSESESYHESTSDGLSNVILEVRHSSEKISTDVSKEGSSVKTTAANKVAPKTGFTSVPVKGKTSRTSSSSSDSSSESDDQCVMPKSTPECTAEFLKTVGLFVGRNCPGPSSQAPNTAGWKQSDPNSGSRTQTVLCPPPNVTLPASLGRGWGRGEDLLSWKGARGRGMRGRGRGRGHAVPYVLNRNADYQKQQQLNEMVTNSSTIIQNPIETQKKDYSLLPLLAAAPQVGEKIAFKLLELTSNYSPDVSDYKEGRILSHNPETQQVDIEILSSLPDNRSLERVN", "length": 581, "header": "tr|A0AAA9SZ99-1|F1MEL4_BOVIN Computationally mapped isoform of Coilin OS=Bos taurus OX=9913 GN=COIL PE=4 SV=1 CANONICAL=F1MEL4-1" }, "locus": { "chromosome": "19", "start_pos": 7786808, "end_pos": 7766257, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099373.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099373.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089623.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089623.1" } ] } }, { "isoform_ac": "F1MEL4-1", "url": "https://www.uniprot.org/uniprotkb/F1MEL4/entry", "sequence": { "sequence": "MESTPLRVALQSSVAATPTNRGHSFIGSRGRAPSTPLGRPVESLGFRCASSKMAASETVRLRLQFDYPPPGAPHCTSFWLLIDLNGCRVVTDLISLIRQRFGFSSGALLGLYLEGALLPPAESARLVRDNDCLRVKLEERGIAESPVTVSNGDSIRLSPRKAKKRAFKLDEDEETELDYRNSKKHWKRHENNNSEKTLDLEPKATTDQSVSKKNKRKNKAMCDAVEVDDGETEKKLPKKKEKREYKKHAKTPKSSKAQSVKEWTIQKCSPKALPARNSLVKAKRKGGMVVRTKDSPDSSSESESYHESTSDGLSNVILEVRHSSEKISTDVSKEGSSVKTTAANKVAPKTGFTSVPVKGKTSRTSSSSSDSSSESDDQCVMPKSTPECTAEFLKTVGLFVGRNCPGPSSQAPNTAGWKQSDPNSGSRTQTVLCPPPNVTLPASLGRGWGRGEDLLSWKGARGRGMRGRGRGRGHAVPYVLNRNADYQKQQQLNEMVTNSSTIIQNPIETQKKDYSLLPLLAAAPQVGEKIAFKLLELTSNYSPDVSDYKEGRILSHNPETQQVDIEILSSLPAMKEPGKFDLVYHNENGAEVVEYAVTQEKRITVLWRELIDPRLIIESPSNT", "length": 623, "header": "tr|F1MEL4-1|F1MEL4_BOVIN Isoform 1 of Coilin OS=Bos taurus OX=9913 GN=COIL PE=4 SV=3 CANONICAL=F1MEL4-1" }, "locus": { "chromosome": "19", "start_pos": 7786808, "end_pos": 7766220, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022956.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022956.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022956.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022956.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1APB5-1", "protein_name": "Coilin", "gene_name": "COIL", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAGGAPVRLRLQFDFPPPGSPGCALCWLLLEPGQARLVTDLLSIIRHRFGFSRRARLSLFLDGALLPPTESARLVRDNDALRVTLEEIAEEGCEEADDDFYAPKDDKKRHKRRQKAQGLSRSGEEKHQREKKKNKYSPECSSGREGTSGDVSDTRKKSKKRKRREENSGTVPRPSEGKKGRADRPPKLQKAQKEERPAAKAKDGRRAALPAAKAAHGRVGGSAPLMAAKSTSKNLTAEAQKQRVGTSESSSTSSDSDSSESNVKQSKSSHRPAAAALPRDKAQTAVTAAACNQMANAEHCSKAAVSKNAKKSQSSSSDSDSSSEDERAAAAQGSTTEQVLPNSAAAAQTGPTGAPKARSSSSSSDSSDSDTIVIKKPAANAGLSNSIARNGSKQSPAGIQGPAAGLGRGRGRAVVEGNFWRGPRGRGFRGMVRGRGRGESPGFFYSYSSEGQKQRQLHEAVTNTSVPVQNAVDVPKRDYSVLPLLAAPPQVGERIAFKRLELNENYSPEVSSYKEGRIISWNADKKQIELEILSSPASQIAKEPGKFDLVYQSADGAELIEYAVPQDTKITESWDSLIEPRLIVEPPMNGSGIENGAV", "length": 600 }, "evidence": [ { "id": "F1MEL4", "url": "https://omabrowser.org/oma/group/F1MEL4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LLE4-1", "protein_name": "Coilin", "gene_name": "Coil", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSKMAASETVRVRLQFDYPPPATPHCTVFWLLVDLNRCRVVTDLISLIRQRFGFSSGALLGLYLEGGLLPPSESARLVRDNDCLRVKLEDQGLPEALIVSNGGDSNFPCRKSKKRAFKLVEDEETDQGYKYPDKYWKRQEDSGPNEKASDLETKLFPDEVRRTKNKRKSKVAGIPAEEDEEETKKKSSKRKEKCEQKKQTRASKSPKQQTHKEGGSQNCSFPRASYRSSLAKARRRSSTGAKGSPSYLSESESCPDSVSDGHCSVTTMQGVTLSEKLSAELLKDGATKTAAANRQSSKPSFTFSSGKGKASRASSSSSDSSSESEDQFLVSKNMLEGASDFLKTTGLFAGQGCSSPGLSLETPGIMGWKPSDSNRGRQAPGPNVPVPTSLGRGWGRGEDFLFGKGLRGRGIRGRGRGRGQTVSCILNRSSESQKQKQLNDILTNSSTVIQVSERLLFVSWPPFPHASYLSPVVWCGVGPPFLTSNEDTCLLQNPVETSKKDYSLLPLLAAAPQVGEKIAFKLLELTSDYSPDVSDYKEGKILSHDPETQQVDIEVLSSLPALKEPGKFDLVYHNENGTEVVEYAVTQEKRITVFWKELIDPRLIIDSSSSISSK", "length": 614 }, "evidence": [ { "id": "F1MEL4", "url": "https://omabrowser.org/oma/group/F1MEL4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "B0S7K8-1", "protein_name": "Coilin", "gene_name": "coil", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MATSSLNTARVRLYFDYPPPATPECRMCWLLVDLNKCRVVADLSSIIKEKFGYSRKTILDLFIEECYLPSAESIYIVRDNDSVRVKVSCPVQVNGTEAEAQNSKSKKRGREDETQTCDGLSKKQKQDNAQMNGLGPDEDEKKKKKKKKKKKKKEVKESITKPATPQKSTAALSTKTKSKSTSAVASSDKTNRTKNHKPASSSSDSSEDESQKKAPPPKPKPSKKPCVAAQKESTDSSSSDETEKLKSSIPLPITPKPSSSTSKLQTPQQRESSSSSSSSPIIKNSQAAGQSSSTTQKSLQPVSSSVPKKPQDEGESSSSDESEIELVIKKPNLQGLGLRIAGVSPGFGEAAGRGRGNAQGQERGRGRGANRGSGRGGFSRARGTPWKQNFHYSYENEERQKPEDSLTNESFILQNPPELAPKRDYATLPLLAAPPAVGQKIAFKLLELTENYTPEVSDYKEGKILAFNPQTKVTELELLSRPQAPAEPGKFDLVYQNPDGSERVEYAVTQGSQLTERWDSLLEPRLIVENAK", "length": 532 }, "evidence": [ { "id": "F1MEL4", "url": "https://omabrowser.org/oma/group/F1MEL4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P38432-1", "protein_name": "Coilin", "gene_name": "COIL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASETVRLRLQFDYPPPATPHCTAFWLLVDLNRCRVVTDLISLIRQRFGFSSGAFLGLYLEGGLLPPAESARLVRDNDCLRVKLEERGVAENSVVISNGDINLSLRKAKKRAFQLEEGEETEPDCKYSKKHWKSRENNNNNEKVLDLEPKAVTDQTVSKKNKRKNKATCGTVGDDNEEAKRKSPKKKEKCEYKKKAKNPKSPKVQAVKDWANQRCSSPKGSARNSLVKAKRKGSVSVCSKESPSSSSESESCDESISDGPSKVTLEARNSSEKLPTELSKEEPSTKNTTADKLAIKLGFSLTPSKGKTSGTTSSSSDSSAESDDQCLMSSSTPECAAGFLKTVGLFAGRGRPGPGLSSQTAGAAGWRRSGSNGGGQAPGASPSVSLPASLGRGWGREENLFSWKGAKGRGMRGRGRGRGHPVSCVVNRSTDNQRQQQLNDVVKNSSTIIQNPVETPKKDYSLLPLLAAAPQVGEKIAFKLLELTSSYSPDVSDYKEGRILSHNPETQQVDIEILSSLPALREPGKFDLVYHNENGAEVVEYAVTQESKITVFWKELIDPRLIIESPSNTSSTEPA", "length": 576 }, "evidence": [ { "id": "F1MEL4", "url": "https://omabrowser.org/oma/group/F1MEL4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5SU73-1", "protein_name": "Coilin", "gene_name": "Coil", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAASETVRLRLQFDYPPPATPHCTVFWLLVDLNRCRVVTDLISLIRQRFGFSSGALLGLYLEGGLLPPAESARLVRDNDSLRVKLEDQGLPENLIVSNGGDSSFPCRKAKKRAFKLMEDEETDQGYKSLKKHCKRQEDSGQNEKASDLETKLLPDETGRTKSKKKSKVTGSPAEEDEEETKKKSSKRKEKCEPKKQTRASKSSKQQTPKEGASQNCSFPRASPRSLGKARRRSSTGLKGSSGHLSESESCPESVSDGHCSVMMQEVTFSEKLSAELLKDAPATKTAAANRQASKPGFTFSSGKGKASRTSSSSSDSSSESEDQFLVSKNMLEGASAGFLKPTGLFAGQGGSGPGLSLETPGIMGWKSSDSNRGRQAPGPPSTPVPTSLGRGWGRGEDLLFGKGLRGRGVRGRGRGRGQAVSCVFNRSSESQKQRQLNDILTNSSVVIQNPVEPPKKDYSLLPLLAAAPQVGEKIAFKLLELTSDYSPDVSDYKEGKILSHDPETQQVDIEVLSSLPALKEPGKFDLVYHNENGTEVVEYAVTQEKRITVLWRELIDPRLIIDSSGSISST", "length": 570 }, "evidence": [ { "id": "F1MEL4", "url": "https://omabrowser.org/oma/group/F1MEL4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8RWK8-1", "protein_name": "Coilin", "gene_name": "COIL", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEEEKVRVRLVFEDRRILSKYQKKQGLTRSWVVLNRKCHRTISEFSDHIFHTFSLCEACPHGLSLSMEGFVLPPFESSCVLKDKDIVCVKKKKESLLEIVGEDSDENVYNAIEVEERPQIRPGEMLLANEEFQKETGGYESESEEDELEEEAEEFVPEKKASKKRKTSSKNQSTKRKKCKLDTTEESPDERENTAVVSNVVKKKKKKKSLDVQSANNDEQNNDSTKPMTKSKRSSQQEESKEHNDLCQLSAETKKTPSRSARRKKAKRQWLREKTKLEKEELLQTQLVVAPSQKPVITIDHQATKEKHCETLENQQAEEVSDGFGDEVVPVEVRPGHIRFKPLAGTDEASLDSEPLVENVLWNGNMTKKKGQKWGTEKSGFSKRYAQDFNEDATTQPAEAETLANCPIDYEQLVAYTGSVKKGDVIAYRLIELTSSWTPEVSSFRVGKISYYDPDSKMVTLMPVQEFPIEKKTEEDDDFCMQPDTSLYKEDGSLEIEFSALLDVRSVKTSSSDSAEVAKSALPEPDQSAKKPKLSANKELQTPAKENGEVSPWEELSEALSAKKAALSQANNGWNKKGSSSGGSWSYKALRGSAMGPVMNYLRSQKEI", "length": 608 }, "evidence": [ { "id": "F1MEL4", "url": "https://omabrowser.org/oma/group/F1MEL4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "U2 snRNA binding", "id": "GO:0030620", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030620", "evidence": [ { "database": "UniProtKB", "id": "F1MEL4", "url": "https://www.uniprot.org/uniprotkb/F1MEL4" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1MEL4", "url": "https://www.uniprot.org/uniprotkb/F1MEL4" } ], "pmid": "" }, { "name": "U1 snRNA binding", "id": "GO:0030619", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030619", "evidence": [ { "database": "UniProtKB", "id": "F1MEL4", "url": "https://www.uniprot.org/uniprotkb/F1MEL4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "F1MEL4", "url": "https://www.uniprot.org/uniprotkb/F1MEL4" } ], "pmid": "" }, { "name": "Cajal body", "id": "GO:0015030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015030", "evidence": [ { "database": "UniProtKB", "id": "F1MEL4", "url": "https://www.uniprot.org/uniprotkb/F1MEL4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "spliceosomal snRNP assembly", "id": "GO:0000387", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000387", "evidence": [ { "database": "UniProtKB", "id": "F1MEL4", "url": "https://www.uniprot.org/uniprotkb/F1MEL4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 437, "end_pos": 439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 498, "end_pos": 500, "annotation": "n_glycosylation_sequon" }, { "start_pos": 540, "end_pos": 542, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MEL4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 623, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MEL4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MEL4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MEL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEL4" }, { "id": "PF15862", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15862" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Coilin N-terminal", "eco_id": "ECO_0000259", "start_pos": 59, "end_pos": 191, "start_aa": "Val", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MEL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEL4" }, { "id": "PF23086", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23086" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Coilin tudor", "eco_id": "ECO_0000259", "start_pos": 511, "end_pos": 603, "start_aa": "Lys", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 192, "end_pos": 194 }, { "start_pos": 437, "end_pos": 439 }, { "start_pos": 498, "end_pos": 500 }, { "start_pos": 540, "end_pos": 542 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MEB9-1", "uniprot_ac": "F1MEB9", "uniprot_id": "F1MEB9_BOVIN", "mass": { "chemical_mass": 45255.0, "monoisotopic_mass": 45255.0 }, "refseq": { "ac": "NP_001193802", "name": "protein arginine N-methyltransferase 8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193802" }, "gene_names": [ { "name": "PRMT8", "type": "recommended", "evidence": [ { "id": "F1MEB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ] }, { "name": "PRMT8", "type": "synonym", "evidence": [ { "id": "NP_001193802", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193802" } ] } ], "protein_names": [ { "name": "type I protein arginine methyltransferase", "type": "recommended", "evidence": [ { "id": "F1MEB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEB9/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.319", "type": "synonym", "evidence": [ { "id": "F1MEB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEB9/entry#names_and_taxonomy" } ] }, { "name": "protein arginine N-methyltransferase 8", "type": "synonym", "evidence": [ { "id": "NP_001193802", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193802" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PRMT8", "url": "https://www.uniprot.org/uniprotkb/F1MEB9", "locus": { "chromosome": "5", "start_pos": 106319035, "end_pos": 106468342, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009447", "url": "https://www.ensembl.org/id/ENSBTAG00000009447" } ] } } ], "crossref": [ { "id": "F1MEB9", "url": "https://alphafold.ebi.ac.uk/entry/F1MEB9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009447", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009447", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615834", "url": "https://www.ncbi.nlm.nih.gov/gene/615834", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR025799", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025799", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615834", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615834", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CTHTKVK", "url": "https://omabrowser.org/oma/group/CTHTKVK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MEB9", "url": "https://www.orthodb.org/?gene=F1MEB9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11006", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11006", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11006:SF47", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11006:SF47", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06325", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06325", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22528", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22528", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193802", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "48096", "url": "https://www.rhea-db.org/rhea/48096", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48100", "url": "https://www.rhea-db.org/rhea/48100", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MGF2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEB9-1", "url": "https://www.uniprot.org/uniprotkb/F1MEB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGMKHSSRCLLLRRKMAENAAESTEVSSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLATVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQVQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNYYKMR", "length": 394, "header": "tr|F1MEB9-1|F1MEB9_BOVIN Isoform 1 of type I protein arginine methyltransferase OS=Bos taurus OX=9913 GN=PRMT8 PE=4 SV=2 CANONICAL=F1MEB9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MGF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGF2/entry", "sequence": { "sequence": "MEPLAAEEFGLKEVSLVSSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLATVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQVQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNYYKMR", "length": 385, "header": "tr|A0A3Q1MGF2-1|F1MEB9_BOVIN Computationally mapped isoform of type I protein arginine methyltransferase OS=Bos taurus OX=9913 GN=PRMT8 PE=4 SV=1 CANONICAL=F1MEB9-1" }, "locus": { "chromosome": "5", "start_pos": 106468342, "end_pos": 106319800, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077297.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077297.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070259.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070259.2" } ] } }, { "isoform_ac": "F1MEB9-1", "url": "https://www.uniprot.org/uniprotkb/F1MEB9/entry", "sequence": { "sequence": "MGMKHSSRCLLLRRKMAENAAESTEVSSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLATVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQVQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNYYKMR", "length": 394, "header": "tr|F1MEB9-1|F1MEB9_BOVIN Isoform 1 of type I protein arginine methyltransferase OS=Bos taurus OX=9913 GN=PRMT8 PE=4 SV=2 CANONICAL=F1MEB9-1" }, "locus": { "chromosome": "5", "start_pos": 106389418, "end_pos": 106319800, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012430.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012430.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012430.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012430.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:615834", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615834", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QGR4-1", "protein_name": "type I protein arginine methyltransferase", "gene_name": "PRMT8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGMKHSSRCLLLRRKMAENAAENTEVSSPPIQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNYYKMR", "length": 394 }, "evidence": [ { "id": "F1MEB9", "url": "https://omabrowser.org/oma/group/F1MEB9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LPN7-1", "protein_name": "type I protein arginine methyltransferase", "gene_name": "Prmt8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGMKHSSRCLLLRRKMAENAVESTEVSSAPPQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNVITIFKGKVEEVELPVDKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR", "length": 394 }, "evidence": [ { "id": "F1MEB9", "url": "https://omabrowser.org/oma/group/F1MEB9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0ABK0M8P3-1", "protein_name": "type I protein arginine methyltransferase", "gene_name": "Prmt8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGMKHSSRCLLLRRKMAENAVESTEVSSAPPQPPQPVIPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNVITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR", "length": 394 }, "evidence": [ { "id": "F1MEB9", "url": "https://omabrowser.org/oma/group/F1MEB9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NJK8-1", "protein_name": "type I protein arginine methyltransferase", "gene_name": "PRMT1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGMKHSSRCLLLRRKMAENGAESTEVCPVPSQTPQPTVVPKPVQSVIHVPLQPGCPGRGKMAKFLSPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKIVLDVGSGTGILSMFAAKAGAKKVYGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVDKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELAFTSAFCLQIQRNDYIHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTIDLDFKGQLCEASVSNDYKMR", "length": 394 }, "evidence": [ { "id": "F1MEB9", "url": "https://omabrowser.org/oma/group/F1MEB9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P38074-1", "protein_name": "Protein arginine N-methyltransferase 1", "gene_name": "HMT1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSKTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYKFESNGIDGNSRSRKNEGSYLMH", "length": 348 }, "evidence": [ { "id": "F1MEB9", "url": "https://omabrowser.org/oma/group/F1MEB9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54EF2-1", "protein_name": "Protein arginine N-methyltransferase 1", "gene_name": "prmt1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTETNKNVDALEKINQMSSADYYFDSYSHFGIHEEMLKDEVRTLAYRRAIINNRKLFEGKVVLDVGCGTGILCMFAAQAGAKMVIGVDNSEMLPIAQKIITANNFDKTITLIKGKMEEVVLPVDKVDIIISEWMGYFMLYEGMLDTVLYARDKYLVPGGVILPDKASLYITAIEDQDYKEEKINYWNNVYGFDMSCIREIALKEPLVDVVQPNMIVTNDCCILTVDIMTITKDELKFRSDFKLKALRDDLIHAFVVYFDIEFSKGDKPVCFSTGPKAKYTHWKQSIMYFEDHIKIQQGEIITGTMDCAPFDKNQRDLKIKLDFNFAGELMKSSSSLEYHMR", "length": 341 }, "evidence": [ { "id": "F1MEB9", "url": "https://omabrowser.org/oma/group/F1MEB9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6PAK3-1", "protein_name": "Protein arginine N-methyltransferase 8", "gene_name": "Prmt8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGMKHSSRCLLLRRKMAENAVESTEVSSAPPQPPQPVIPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNVITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR", "length": 394 }, "evidence": [ { "id": "F1MEB9", "url": "https://omabrowser.org/oma/group/F1MEB9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NR22-1", "protein_name": "Protein arginine N-methyltransferase 8", "gene_name": "PRMT8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGMKHSSRCLLLRRKMAENAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR", "length": 394 }, "evidence": [ { "id": "F1MEB9", "url": "https://omabrowser.org/oma/group/F1MEB9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9SU94-1", "protein_name": "Protein arginine N-methyltransferase 1.1", "gene_name": "PRMT11", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MTKNSNHDENEFISFEPNQNTKIRFEDADEDEVAEGSGVAGEETPQDESMFDAGESADTAEVTDDTTSADYYFDSYSHFGIHEEMLKDVVRTKTYQNVIYQNKFLIKDKIVLDVGAGTGILSLFCAKAGAAHVYAVECSQMADMAKEIVKANGFSDVITVLKGKIEEIELPTPKVDVIISEWMGYFLLFENMLDSVLYARDKWLVEGGVVLPDKASLHLTAIEDSEYKEDKIEFWNSVYGFDMSCIKKKAMMEPLVDTVDQNQIVTDSRLLKTMDISKMSSGDASFTAPFKLVAQRNDYIHALVAYFDVSFTMCHKLLGFSTGPKSRATHWKQTVLYLEDVLTICEGETITGTMSVSPNKKNPRDIDIKLSYSLNGQHCKISRTQHYKMR", "length": 390 }, "evidence": [ { "id": "F1MEB9", "url": "https://omabrowser.org/oma/group/F1MEB9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VGW7-1", "protein_name": "type I protein arginine methyltransferase", "gene_name": "Art1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MASTDIPMEAAVESATGITPNSNANSNNVAKKLPAEGSTGDNPNANADEMTSRDYYFDSYAHFGIHEEMLKDEVRTVTYRNAMYHNKHLFQGKTVLDVGCGTGILSMFAAKAGAAQVIAVDCSNIIEFARQVVIDNNLQDVITVVKGKIEEIELPNGIEGVDIIISEWMGYCLFYESMLDTVLYARDKWLKKDGMMFPDRGTLYITAIEDRQYKDEKINWWDDVYGFDMSCIRKVAVTEPLVDVVDPKQVVSTSCMVKEVDLYTVQKADLNFSSKFSLCIKRNDFVQALVTYFNIEFTKCHKRLGFSTSPDSTYTHWKQTVFYLDDHMTAKKNEEITGTFQMKPNERNNRDLDFVIDINFKGELSQIQESNTYRMR", "length": 376 }, "evidence": [ { "id": "F1MEB9", "url": "https://omabrowser.org/oma/group/F1MEB9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "protein-arginine omega-N asymmetric methyltransferase activity", "id": "GO:0035242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035242", "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "pmid": "" }, { "name": "histone methyltransferase activity", "id": "GO:0042054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042054", "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "pmid": "" }, { "name": "protein-arginine omega-N monomethyltransferase activity", "id": "GO:0035241", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035241", "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "pmid": "" }, { "name": "S-adenosyl-L-methionine binding", "id": "GO:1904047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904047", "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "pmid": "" }, { "name": "histone H4 methyltransferase activity", "id": "GO:0140939", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140939", "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "pmid": "" }, { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "pmid": "" }, { "name": "regulation of modification of postsynaptic actin cytoskeleton", "id": "GO:1905274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905274", "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "pmid": "" }, { "name": "cytoplasmic side of plasma membrane", "id": "GO:0009898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009898", "evidence": [ { "database": "UniProtKB", "id": "F1MEB9", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "48096", "name": "", "equation": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0ABZ3NNC5-1", "A0A3Q1MWG1-1", "Q5E9L5-1", "F1MEB9-1", "F1MQ97-1", "F6R040-1" ], "evidence": [ { "id": "48096", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48096" } ] }, { "id": "48100", "name": "", "equation": "L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0ABZ3NNC5-1", "A6QQV6-1", "F1MQX7-1", "F1MEB9-1" ], "evidence": [ { "id": "48100", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48100" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MWG1", "gene_name": "CARM1", "activity": [ { "ec_number": "2.1.1.319", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "A0A3Q1MWG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWG1" } ] }, { "ec_number": "2.1.1.319", "activity": "", "evidence": [ { "id": "A0A3Q1MWG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MWG1" } ] } ] }, { "uniprot_ac": "A0ABZ3NNC5", "gene_name": "PRMT1", "activity": [ { "ec_number": "2.1.1.319", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "A0ABZ3NNC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNC5" } ] }, { "ec_number": "2.1.1.319", "activity": "", "evidence": [ { "id": "A0ABZ3NNC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABZ3NNC5" } ] } ] }, { "uniprot_ac": "A6QQV6", "gene_name": "PRMT7", "activity": [ { "ec_number": "2.1.1.321", "activity": "L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "A6QQV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQV6" } ] }, { "ec_number": "2.1.1.321", "activity": "", "evidence": [ { "id": "A6QQV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQV6" } ] } ] }, { "uniprot_ac": "F1MEB9", "gene_name": "PRMT8", "activity": [ { "ec_number": "2.1.1.319", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "F1MEB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ] }, { "ec_number": "2.1.1.319", "activity": "", "evidence": [ { "id": "F1MEB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" } ] } ] }, { "uniprot_ac": "F1MQ97", "gene_name": "METTL23", "activity": [ { "ec_number": "2.1.1.319", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "F1MQ97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ97" } ] }, { "ec_number": "2.1.1.319", "activity": "", "evidence": [ { "id": "F1MQ97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ97" } ] } ] }, { "uniprot_ac": "F1MQX7", "gene_name": "PRMT7", "activity": [ { "ec_number": "2.1.1.321", "activity": "L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "F1MQX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQX7" } ] }, { "ec_number": "2.1.1.321", "activity": "", "evidence": [ { "id": "F1MQX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQX7" } ] } ] }, { "uniprot_ac": "F6R040", "gene_name": "PRMT2", "activity": [ { "ec_number": "2.1.1.319", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "F6R040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R040" } ] }, { "ec_number": "2.1.1.319", "activity": "", "evidence": [ { "id": "F6R040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R040" } ] } ] }, { "uniprot_ac": "Q5E9L5", "gene_name": "PRMT6", "activity": [ { "ec_number": "2.1.1.319", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "Q5E9L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L5" } ] }, { "ec_number": "2.1.1.319", "activity": "", "evidence": [ { "id": "Q5E9L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MEB9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 394, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MEB9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MEB9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MEB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEB9" }, { "id": "PF22528", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22528" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein arginine N-methyltransferase", "eco_id": "ECO_0000259", "start_pos": 217, "end_pos": 381, "start_aa": "Asp", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.319", "ec_name": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "2.1.1.319", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319" }, { "id": "2.1.1.319", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.319" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MAZ0-1", "uniprot_ac": "F1MAZ0", "uniprot_id": "F1MAZ0_BOVIN", "mass": { "chemical_mass": 81988.0, "monoisotopic_mass": 81988.0 }, "refseq": { "ac": "NP_001179930", "name": "zinc finger and BTB domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179930" }, "gene_names": [ { "name": "ZBTB1", "type": "recommended", "evidence": [ { "id": "F1MAZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ] }, { "name": "ZBTB1", "type": "synonym", "evidence": [ { "id": "NP_001179930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179930" } ] } ], "protein_names": [ { "name": "Zinc finger and BTB domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "F1MAZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0/entry#names_and_taxonomy" } ] }, { "name": "zinc finger and BTB domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001179930", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179930" } ] } ], "function": [ { "annotation": "Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development.", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0#function" }, { "database": "UniProtKB", "id": "ARBA00059022", "url": "https://www.uniprot.org/uniprotkb/ARBA00059022#function" }, { "database": "UniProtKB", "id": "A0A3Q1MJA0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJA0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZBTB1", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0", "locus": { "chromosome": "10", "start_pos": 76675068, "end_pos": 76612009, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040551", "url": "https://www.ensembl.org/id/ENSBTAG00000040551" } ] } } ], "crossref": [ { "id": "ENSBTAG00000040551", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040551", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18192", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18192", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526903", "url": "https://www.ncbi.nlm.nih.gov/gene/526903", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526903", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526903", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EDDWPEA", "url": "https://omabrowser.org/oma/group/EDDWPEA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MJA0", "url": "https://www.orthodb.org/?gene=A0A3Q1MJA0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MAZ0", "url": "https://www.orthodb.org/?gene=F1MAZ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179930", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJA0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJA0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MAZ0-1", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDADCSSSKCSSSASSKQNSKMIFGVRMYEDTVARNGSEANRWCAEPSSTVNTPHNREPDEESLQLGNFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHSYQNTRSYHRLVDIRDGKDSNIKAEFGEKDSSKTFSAQTDKYRGDTSQAADDSASTTGSRKSSTVESELASEEKSRAAERKRIIIKMEPEDIPTDELKDFNIIKVTDKDCNESTDNDELEDEAEEPFYRYYVEEDVSIKKSGRKTLKPRMSINADERGGLENMRPPNNSSPVQEDTENASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNAEEKMDMEENPDEQSEIRDMFVEMLDDFRDNHFQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDVFKSAIMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSAGETICQVCFQIFPNNEQLEQHMDIHLYTCGICGAKFNLRKDMRSHYNAKHLKRT", "length": 713, "header": "tr|F1MAZ0-1|F1MAZ0_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 1 OS=Bos taurus OX=9913 GN=ZBTB1 PE=4 SV=2 CANONICAL=F1MAZ0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MJA0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJA0/entry", "sequence": { "sequence": "MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDADCSSSKCSSSASSKQNSKMIFGVRMYEDTVARNGSEANRWCAEPSSTVNTPHNREPDEESLQLGNFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHSYQNTRSYHRLVDIRDGKDSNIKAEFGEKDSSKTFSAQTDKYRGDTSQAADDSASTTGSRKSSTVESELASEEKSRAAERKRIIIKMEPEDIPTDELKDFNIIKVTDKDCNESTDNDELEDEAEEPFYRYYVEEDVSIKKSGRKTLKPRMSINADERGGLENMRPPNNSSPVQEDTENASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNAEEKMDMEENPDEQSEIRDMFVEMLDDFRDNHFQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDVFKSAIMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMASGQIGPSKPLEK", "length": 644, "header": "tr|A0A3Q1MJA0-1|F1MAZ0_BOVIN Computationally mapped isoform of Zinc finger and BTB domain-containing protein 1 OS=Bos taurus OX=9913 GN=ZBTB1 PE=4 SV=1 CANONICAL=F1MAZ0-1" }, "locus": { "chromosome": "10", "start_pos": 76672893, "end_pos": 76663877, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072466.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072466.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071409.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071409.1" } ] } }, { "isoform_ac": "F1MAZ0-1", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0/entry", "sequence": { "sequence": "MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDADCSSSKCSSSASSKQNSKMIFGVRMYEDTVARNGSEANRWCAEPSSTVNTPHNREPDEESLQLGNFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHSYQNTRSYHRLVDIRDGKDSNIKAEFGEKDSSKTFSAQTDKYRGDTSQAADDSASTTGSRKSSTVESELASEEKSRAAERKRIIIKMEPEDIPTDELKDFNIIKVTDKDCNESTDNDELEDEAEEPFYRYYVEEDVSIKKSGRKTLKPRMSINADERGGLENMRPPNNSSPVQEDTENASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNAEEKMDMEENPDEQSEIRDMFVEMLDDFRDNHFQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDVFKSAIMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSAGETICQVCFQIFPNNEQLEQHMDIHLYTCGICGAKFNLRKDMRSHYNAKHLKRT", "length": 713, "header": "tr|F1MAZ0-1|F1MAZ0_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 1 OS=Bos taurus OX=9913 GN=ZBTB1 PE=4 SV=2 CANONICAL=F1MAZ0-1" }, "locus": { "chromosome": "10", "start_pos": 76666015, "end_pos": 76663877, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095679.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095679.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084745.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084745.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:526903", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526903", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480E3Y5-1", "protein_name": "Zinc finger and BTB domain-containing protein 1", "gene_name": "ZBTB1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDADCSSSKCSSSASSKQNSKMIFGVRMYEDTVARNGSEASRWCAEPSSTVNTPHNREPDEESLQLGNFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHSYQNTRSYHRIVDIRDGKDSNIKTEFGEKDSSKAFCAQTDKYRGDTSQAADDSTSTTGSRKSSTVETELASEEKSRAAERKRIIIKMEPEDIPTDELKDFNIIKVTDKDCNESTDNDELEDEPEEPFYRYYVEEDVSIKKSGRKTLKPRMSINADERGGLENMRPPNNSSPVQEDTENASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNAEEKMDMEENPDEQSEIRDMFVEMLDDFRDNHFQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDMFKSAIMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSAGETICQVCFQIFPNNEQLEQHMDVHLYTCGICGAKFNLRKDMRSHYNAKHLKRT", "length": 713 }, "evidence": [ { "id": "F1MAZ0", "url": "https://omabrowser.org/oma/group/F1MAZ0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7G6E1-1", "protein_name": "Zinc finger and BTB domain-containing protein 1", "gene_name": "Zbtb1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDADCSSSKCSSSASSKQNSKMIFGVRMYEDTVARNGNEANRWCAEPSSTVNTPHNREPDEESLQLATFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHSYQNTARAYHRIVDIRDGKDSNIKAELGEKDSSKTFSAQTDKYREDASQAPDGSASTTASRKSTVESGMAGEEKSRAAETKRIIIKMEPEDIPTDEMKDFNIIKVTDKDCNESTDNDELEDEPEEPFYRYYVEEDVGIKKSGRKTLKPRMSVSVDERSGLESMRPPNNSSPIQEDTDNASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNAEEKMDMEENPDEQSEIRDMFVEMLDDFRDSHYQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDMFKSAIMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMARMNHTNNIDKGYDLFKVKTKALPQSSRKPSVVSSLGRACLFCYTTDNTDGQNLADLIIFNGL", "length": 694 }, "evidence": [ { "id": "F1MAZ0", "url": "https://omabrowser.org/oma/group/F1MAZ0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1NNE5-1", "protein_name": "Zinc finger and BTB domain-containing protein 1", "gene_name": "PPP1R36", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARTSHSNYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMFFMNHQHTTAQLNLSNMKISAECFDLILQFMYLGKIMTAPANFEQFKVAMNYLQLYNVPECLEDIQDTDSSSLKCSSSASSTQNSKMIFGVRMYEDTLARNGSETNRWGMEPPSSTVNTSHNKEPEEEALQLSSFPEQLFDVCKKSTTSKYSHTKERVSHSRRFGRSFTCDSCGFSFSCEKLLDEHVLSCTNRHSYQSARYYGAEKIDFNEKDSASKIISTQTEKCKGDSSQVADDSSSPVSNITSRKSSTVASETSGEEGSRASERKRIVIKMEPEDSPADELKDYNIIKVTDKDCNESSDNDDLDDEQEEPLYRYYVEEEMREKRNARKTLKPRLSMDEDERRCLKSPRHLNRKAPSVQEDVENAPCELCGLTITEEDLSSHYLSKHIENICACGKCGQILVKGKQLQDHAQTCGEPQDLTMNGIRNSEEKMDLEENPEEQSEIRDMMFADMLEDFRDSHFQMNSLQKKQLYKHSACPFRCPNCGQRFETENLVVEHMSNCLEQDLFKNSMMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSAGETICQVCFQIFPNNEQLEQHMDVHLYTCGVCGAKFNLRKDMRSHYNAKHLKRT", "length": 711 }, "evidence": [ { "id": "F1MAZ0", "url": "https://omabrowser.org/oma/group/F1MAZ0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q672J3-1", "protein_name": "Zinc finger and BTB domain containing 1", "gene_name": "Zbtb1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVDSRSACLLEVTTVGLTRGRTETDRPKSSSLVLNRCKQAHRQEMAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDTYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKILTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDSDCSSSKCSSSASSKHNSKMIFGVRMYEDTVARNGSEANRWSAEPSSTVNTPHNREPEEESLPLANFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHSYQSTARAYHRVVDARDGKDSAIKAELGDKGSPTAFSAHTDKYREDASQAPDDSASPTGSRKSTVESGTAGEEKSRAAETKRVVIKMEPEDVPADDMKDFTIVKVTEKDCNESTDNDELEDEPEEPFYRYYVEEDVGIKKSGRKTLKPRMSVGVDERGGLENMRPPNNSSPRQEDAENASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNTDEKMDMEENPDEQSEIRDMFVEMLDDFRDNHYQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDMFKGAVMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSGGETICQVCFQIFPNNEQLEQHMDVHLYTCGICGAKFNLRKDMRSHYNAKHLKRT", "length": 757 }, "evidence": [ { "id": "F1MAZ0", "url": "https://omabrowser.org/oma/group/F1MAZ0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91VL9-1", "protein_name": "Zinc finger and BTB domain-containing protein 1", "gene_name": "Zbtb1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDADCSSSKCSSSASSRQSSKMIFGVRMYEDTVARNGNEANRWCAEPSSTVNTPHHREPEEESLQLANFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHSYQNTTRAYHRIVDIRDGKDSNIKAELAEKDSSKTFSAQPDKYREDANQAPDDSASTTGSRKSTVEAGIAGEEKSRATETKRIIIKMEPEDIPADDMKDFNIIKVTEKDCNESTDNDELEDEPEEPFYRYYVEEDVGIKKSGRKTLKPRMSISVDERGGLENMRPPNNTSPIQEDAENASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNADEKMDMEENPDEQSEIRDMFVEMLDDFRDNHYQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDMFKGAIMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSGGETICQVCFQIFPNNEQLEQHMDVHLYTCGICGAKFNLRKDMRSHYNAKHLKRT", "length": 713 }, "evidence": [ { "id": "F1MAZ0", "url": "https://omabrowser.org/oma/group/F1MAZ0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y2K1-1", "protein_name": "Zinc finger and BTB domain-containing protein 1", "gene_name": "ZBTB1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDADCSSSKCSSSASSKQNSKMIFGVRMYEDTVARNGNEANRWCAEPSSTVNTPHNREADEESLQLGNFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHLYQNTRSYHRIVDIRDGKDSNIKAEFGEKDSSKTFSAQTDKYRGDTSQAADDSASTTGSRKSSTVESEIASEEKSRAAERKRIIIKMEPEDIPTDELKDFNIIKVTDKDCNESTDNDELEDEPEEPFYRYYVEEDVSIKKSGRKTLKPRMSVSADERGGLENMRPPNNSSPVQEDAENASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNTEEKMDLEENPDEQSEIRDMFVEMLDDFRDNHYQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDMFKSAIMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSAGETICQVCFQIFPNNEQLEQHMDVHLYTCGICGAKFNLRKDMRSHYNAKHLKRT", "length": 713 }, "evidence": [ { "id": "F1MAZ0", "url": "https://omabrowser.org/oma/group/F1MAZ0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "K63-linked polyubiquitin modification-dependent protein binding", "id": "GO:0070530", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070530", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 15, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "positive regulation of T cell mediated immunity", "id": "GO:0002711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002711", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "thymus development", "id": "GO:0048538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048538", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "cellular response to UV", "id": "GO:0034644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034644", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "mRNA transcription by RNA polymerase II", "id": "GO:0042789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042789", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "translesion synthesis", "id": "GO:0019985", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019985", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "positive regulation of pro-T cell differentiation", "id": "GO:2000176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000176", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" }, { "name": "positive regulation of natural killer cell differentiation", "id": "GO:0032825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032825", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ0", "url": "https://www.uniprot.org/uniprotkb/F1MAZ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 353, "end_pos": 355, "annotation": "n_glycosylation_sequon" }, { "start_pos": 409, "end_pos": 411, "annotation": "n_glycosylation_sequon" }, { "start_pos": 410, "end_pos": 412, "annotation": "n_glycosylation_sequon" }, { "start_pos": 420, "end_pos": 422, "annotation": "n_glycosylation_sequon" }, { "start_pos": 64, "end_pos": 66, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1ME62-1", "uniprot_ac": "F1ME62", "uniprot_id": "F1ME62_BOVIN", "mass": { "chemical_mass": 441084.0, "monoisotopic_mass": 441084.0 }, "refseq": {}, "gene_names": [ { "name": "CMYA5", "type": "recommended", "evidence": [ { "id": "F1ME62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME62" } ] } ], "protein_names": [ { "name": "Cardiomyopathy-associated protein 5", "type": "recommended", "evidence": [ { "id": "F1ME62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME62/entry#names_and_taxonomy" } ] }, { "name": "Myospryn", "type": "synonym", "evidence": [ { "id": "F1ME62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME62/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1ME62", "url": "https://www.uniprot.org/uniprotkb/F1ME62" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CMYA5", "url": "https://www.uniprot.org/uniprotkb/F1ME62", "locus": { "chromosome": "10", "start_pos": 10773418, "end_pos": 10675335, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006823", "url": "https://www.ensembl.org/id/ENSBTAG00000006823" } ] } } ], "crossref": [ { "id": "ENSBTAG00000006823", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006823", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050617", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050617", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KPNLAPN", "url": "https://omabrowser.org/oma/group/KPNLAPN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MLM4", "url": "https://www.orthodb.org/?gene=A0A3Q1MLM4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1ME62", "url": "https://www.orthodb.org/?gene=F1ME62", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24099", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24099", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24099:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24099:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MLM4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLM4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME62", "url": "https://www.uniprot.org/uniprotkb/F1ME62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME62-1", "url": "https://www.uniprot.org/uniprotkb/F1ME62-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSDGSHAAESALGADEEETRAPDAEEQSGGEEDESAVESESESESEPDARLSDQDEEGKTEKKCIISDPSFSMVTVQQEDSGITWETSSSRPSTPWASEESQTSGVCSLEGSTLNSPPGNVSFILDEVKKVRKRKPKSKHGSPSLRRKGNKKRNSFESQDVPANKTSTPLISESQELTTQKDKSSTGAYDKMRKKKSTSSTPPITGAIYKEYKPLVLRPVYIGTVQYKIKMFNSVKEELIPLQFYGTLPKGYVIKEIHYRKGKEASISLEPESGNCDLKVVSKTGKSVAQSIEDVKVKELAPPWRDAFSKGSKSLTSLFSHEDQKKTYDDFPLRAASAAQHTASSHTSHAIAERESQLSPPRVVPRLLVDEAKPREMKPSFLTPDTSVATFLETAKEESEADSQEIVIAEPDSSASPPVLDEVKTEDMSSVDHSISLEAEKGSLESGAPGLTASIQEDFSPERDKLDLTSRERVEPVTDQLTPPHLIIKGGKGETVPEPSISLFEPLVLEEPEKEEIEMPLPMAATPEPEDSNLVEEEIIELDYPESPSVSEEPFPPRLAPEVEEKEETPLPLLTTSTPEHVTLSEEEREENESVSTDSAFVSEYSAPQDWNYELEKQEAEPVSLPHVKAVSEHAVLSEEEDDKFEPSSPTSASIFVSPSTTEKTLECQSPLFSAVTPEPMILSGEEASESGHYTPDSTSASEYLVPSQATEESPKKTVDLKSPLKSQGVSEPLILSEEENEDPGLCSPEVASLSERSVSPHTTEGTSEGQAPLLSAVTSEHAILSEEENLGNEGVTRDSALTFQNAVPPNVRQESPKNIIDDVSLLKSEGVSEHKTVLEEEKEDAGFYTPEVASLPEGFLPPSTTEGTPECQVPRLSVAPPDHVVLSEEETVEMERYTPSSTSASELSEPPYATPESQEEEIVHTSPLNLKGSSSPMIFSEEEQEDIGPFSPDSAFVSEFSFPPYATTGKREFECDSPICLTSPSEHTILSDEDTEETELFSPDSASQASIPPYRIPEMNKKEIEPDSLLTAMAASGYPRFSEADEEEIAPTTTTPVPEHLSSLQKQRAEPSVSAPEDLSQLPSTNEAEKAEIKPDAQTTSASVSEYLILAQKQRTQTYLEPEPEDSIPPSLTSDSERGETKSSSSLAAAPAVKEVPTVKEETKPVLPASQCSVSPDSVHAIKKEQEPQTSLTPKSADEQMALLKVESKEEIVPDSQEAIAHVLQDQEMEPQPPNVPDSGMKDSVLPDLADEPKKDVKPNLAPTLTSELEQRRLSEKEPEVTKPYSPLKETSLSRPEISSVVKTEVKLDSKVTGTPRVLRSASPGVEQEVEHGPPVPEFEFSALSEEIKKEIEPSSSITATSETKHDSNLTKLAKEEIPKNLPLTTPIEHQVLTKGEKSELGSGLPPVDEHSLFKEDKVAIKASPSPTETAASQYPAWSEVEKEIKFDLPASISSISEHSVLSKVETEDIKPGLAITKTLSSQHSDVSKEARVEDKQDLSFPTVLDSEYLDLSQKKISVSASEMSGPEHVPSLSLGGEIKKTETELPSSQNMSPAPKYIVPKGKDEVTASSVPELKHLTSEDLASTFLTFSGDKREQAVETPSVIQGDFRSEKAGLALAQLSLEPEKRDKTHPVSEFPDTGNAGSEFAGDVNRQSGSIQTEHIKSPLPETENSALEKGLPELRSRGEGKEENRELHVSTTVPKISEVSSYLREEPQIQEMKSLSAKVVSLGSREAFTSQLEGDSLEEFQSHTLSSKGLSEELNRSADFKKEEKQEISPLQPAGNLKAQETEDTVTKPNETDQPNSFHVLQSITEPSNITSSDLFVQQKPEEAFVSDQAATLPEISRSFADKQDLGIKQVLFMKENLPLEESKLFMTTEPTNVRETHMKEALISPKDENWMLKEPEGDLVSHHEERAMESVQLDHSGTNDLMTGQLKPALPEKDHMPEIRKQILPPSAEEPHIAFQEPVSTLDTSRDNVETLATETYSSEDIKLAPKPKSLVPAGNVERSEAEGKQTLSFVGGESLVVEKANTEISRPCKEGSQEEIKTPYEGGLQKPVSGPSVEQVKSETPPSLVKAARALAEEAEPALGVEKEAHGRISPLPGEKPLEESNVVQPKVADDANERGKPPSEVKAPTQIKPLSSTQENEEPQPLESPEVIQKPPKQQKAVEPSISEEKGKKGISSFTSWVSSFFFRSSTLDNEVAEKEDLEAQPSPSEEKTVTVIDSEGPAPADVHGTEKPVSHLFLEAKRETASESAGSLVKSGEHQDFKEKPALLSDVEVSPQPKSNFEASSDDYGKKEVLDYSGEMDLTSVVTSADGEGHLRIQSDSPMGEKSIMEEAKNAVPLHVTDSKRLQKPEISPRSKWNISILKEEPRSDQKEKTLFLVDATDKVPQQPESGSSSFASKDITEESEKLESIILPGEEPKGSLIDLGEDRLGKEMPKPVSLKISEEEVKLRSVSPAEEKGNLGMRSYSLAEKKVLAEKQEIAAPLEHRDINEIEKAKIIHGPSPVKLEEPKAATVLQQVYQNEDHKERYKIIEEEKGEEKEERSHAFSEGREQEIQPYSISIAGHPPEESDISFHLTLGETQPFSLVKTTEAAETLETTISEAYSEIRETKAVGSQPHPLEEREVLVEETKAFLPVDLPYHDEINEPSLPKEGNLVLEKSSRDVVTHSEEKGQVIVSELPKAGSVGTTEESKQGSPSKESERILDRPFGETKSLETPSYLLSSVKPQTLTSEASPEVSPEKKQELPWSEVTPHRPTVHTTQTSKDQTSEMFEQPVLVSKHHLEAVEDSQVYEPCPSASSNYAQFITNASTISADEVVSKEPEDTSVRDEEFTVTSKPAGLSEEQKSAFSIISEGCEILNIHAPAFISSVDQEESEQMQDKLEYLEEKISFKPILLRDESEEVACHKTLQSKLEDSDIKVISLKEDQQKEIHTTKEEIPTDSETGDLAFNQPTSPDEEDYFEKYTLIDYNIFPDPEKQSAPWKLEAGLSKEVPEETVSFPEHSEEGALEHEYDLVKLDESFYGLEKDYSKLSDPETQKSLVIQKLTDRDAPKSTDRDVGSKSPGMPLFDEEEGVLSRTQIFPTTAKAINPELLEEPPALAFLYKDLYEEAVGEKKKEGETASEGDSVNSEASFPSRNSDTDDGTGIYFEKYILKDDILHDTCVTEKDQGQGLEEKPIDKDDSYQPITAEGEIWGKFATIGREESLEEKQKAAYREGESVGHMETLDNVAMQRKAPITEEVRVVTQRISYAVPFEDTHHVLERVDETSSQTNEAANANPEVSLNVPVQVSFPEEEFASGATCMQEILQEEPQIMVPPEPSEDWVRSSPVQDEYEFAESLNYEVVTQDTLSEDLYSESTPEDVLSQGKESFEHVSENELVTEAEQRKSAEQKELDIEMAEQDQLLSELVTEKEQKEMKTSQIDTYCYTCKSPISAVDKMLGTHKDHEISTLDTAISAVKVQLADFLEDLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQSFEEVKRKKMEFLHDQMVHFLQSMDTAKDTLETIVREAEELDETVFLTSFEEINERLLSAMENTASLEKMPAAFSLFEHYDDSSARSDQMLKQVAVPQPPRLEPQELNSATSTTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNDLVEEYRVTVKESYCVFEDLEPDRCYQVWVMAVNFTGCSLPSERAIFRTAPSTPVIRAEDCTVCWNTATIRWRPASPEATETYTLEYCRQHAPEGEGLRSFSGIKGLQLKVNLQPNDNYFFYVRAINAFGTSEQSEAALISTRGTRFLLLRETAHPALQISSNGTVISFAERRRLTEIPSVLGEELPACGQHYWETTVTDCPAYRLGVCSSSAVQAGALAQGETSWYMHCSEPQRYTFFYSGIVSDVHVTERPARVGILLDYTTQRLLFINAETGQMLFIIRHRFNEGVHPAFALEKPGKCTLHLGIEPPDSARQK", "length": 3988, "header": "tr|F1ME62-1|F1ME62_BOVIN Isoform 1 of Cardiomyopathy-associated protein 5 OS=Bos taurus OX=9913 GN=CMYA5 PE=4 SV=3 CANONICAL=F1ME62-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MLM4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLM4/entry", "sequence": { "sequence": "MASSDGSHAAESALGADEEETRAPDAEEQSGGEEDESAVESESESESEPDARLSDQDEEGKTEKKCIISDPSFSMVTVQQEDSGITWETSSSRPSTPWASEESQTSGVCSLEGSTLNSPPGNVSFILDEVKKVRKRKPKSKHGSPSLRRKGNKKRNSFESQDVPANKTSTPLISESQELTTQKDKSSTGAYDKMRKKKSTSSTPPITGAIYKEYKPLVLRPVYIGTVQYKIKMFNSVKEELIPLQFYGTLPKGYVIKEIHYRKGKEASISLEPESGNCDLKVVSKTGKSVAQSIEDVKVKELAPPWRDAFSKGSKSLTSLFSHEDQKKTYDDFPLRAASAAQHTASSHTSHAIAERESQLSPPRVVPRLLVDEAKPREMKPSFLTPDTSVATFLETAKEESEADSQEIVIAEPDSSASPPVLDEVKTEDMSSVDHSISLEAEKGSLESGAPGLTASIQEDFSPERDKLDLTSRERVEPVTDQLTPPHLIIKGGKGETVPEPSISLFEPLVLEEPEKEEIEMPLPMAATPEPEDSNLVEEEIIELDYPESPSVSEEPFPPRLAPEVEEKEETPLPLLTTSTPEHVTLSEEEREENESVSTDSAFVSEYSAPQDWNYELEKQEAEPVSLPHVKAVSEHAVLSEEEDDKFEPSSPTSASIFVSPSTTEKTLECQSPLFSAVTPEPMILSGEEASESGHYTPDSTSASEYLVPSQATEESPKKTVDLKSPLKSQGVSEPLILSEEENEDPGLCSPEVASLSERSVSPHTTEGTSEGQAPLLSAVTSEHAILSEEENLGNEGVTRDSALTFQNAVPPNVRQESPKNIIDDVSLLKSEGVSEHKTVLEEEKEDAGFYTPEVASLPEGFLPPSTTEGTPECQVPRLSVAPPDHVVLSEEETVEMERYTPSSTSASELSEPPYATPESQEEEIVHTSPLNLKGSSSPMIFSEEEQEDIGPFSPDSAFVSEFSFPPYATTGKREFECDSPICLTSPSEHTILSDEDTEETELFSPDSASQASIPPYRIPEMNKKEIEPDSLLTAMAASGYPRFSEADEEEIAPTTTTPVPEHLSSLQKQRAEPSVSAPEDLSQLPSTNEAEKAEIKPDAQTTSASVSEYLILAQKQRTQTYLEPEPEDSIPPSLTSDSERGETKSSSSLAAAPAVKEVPTVKEETKPVLPASQCSVSPDSVHAIKKEQEPQTSLTPKSADEQMALLKVESKEEIVPDSQEAIAHVLQDQEMEPQPPNVPDSGMKDSVLPDLADEPKKDVKPNLAPTLTSELEQRRLSEKEPEVTKPYSPLKETSLSRPEISSVVKTEVKLDSKVTGTPRVLRSASPGVEQEVEHGPPVPEFEFSALSEEIKKEIEPSSSITATSETKHDSNLTKLAKEEIPKNLPLTTPIEHQVLTKGEKSELGSGLPPVDEHSLFKEDKVAIKASPSPTETAASQYPAWSEVEKEIKFDLPASISSISEHSVLSKVETEDIKPGLAITKTLSSQHSDVSKEARVEDKQDLSFPTVLDSEYLDLSQKKISVSASEMSGPEHVPSLSLGGEIKKTETELPSSQNMSPAPKYIVPKGKDEVTASSVPELKHLTSEDLASTFLTFSGDKREQAVETPSVIQGDFRSEKAGLALAQLSLEPEKRDKTHPVSEFPDTGNAGSEFAGDVNRQSGSIQTEHIKSPLPETENSALEKGLPELRSRGEGKEENRELHVSTTVPKISEVSSYLREEPQIQEMKSLSAKVVSLGSREAFTSQLEGDSLEEFQSHTLSSKGLSEELNRSADFKKEEKQEISPLQPAGNLKAQETEDTVTKPNETDQPNSFHVLQSITEPSNITSSDLFVQQKPEEAFVSDQAATLPEISRSFADKQDLGIKQVLFMKENLPLEESKLFMTTEPTNVRETHMKEALISPKDENWMLKEPEGDLVSHHEERAMESVQLDHSGTNDLMTGQLKPALPEKDHMPEIRKQILPPSAEEPHIAFQEPVSTLDTSRDNVETLATETYSSEDIKLAPKPKSLVPAGNVERSEAEGKQTLSFVGGESLVVEKANTEISRPCKEGSQEEIKTPYEGGLQKPVSGPSVEQVKSETPPSLVKAARALAEEAEPALGVEKEAHGRISPLPGEKPLEESNVVQPKVADDANERGKPPSEVKAPTQIKPLSSTQENEEPQPLESPEVIQKPPKQQKAVEPSISEEKGKKGISSFTSWVSSFFFRSSTLDNEVAEKEDLEAQPSPSEEKTVTVIDSEGPAPADVHGTEKPVSHLFLEAKRETASESAGSLVKSGEHQDFKEKPALLSDVEVSPQPKSNFEASSDDYGKKEVLDYSGEMDLTSVVTSADGEGHLRIQSDSPMGEKSIMEEAKNAVPLHVTDSKRLQKPEISPRSKWNISILKEEPRSDQKEKTLFLVDATDKVPQQPESGSSSFASKDITEESEKLESIILPGEEPKGSLIDLGEDRLGKEMPKPVSLKISEEEVKLRSVSPAEEKGNLGMRSYSLAEKKVLAEKQEIAAPLEHRDINEIEKAKIIHGPSPVKLEEPKAATVLQQVYQNEDHKERYKIIEEEKGEEKEERSHAFSEGREQEIQPYSISIAGHPPEESDISFHLTLGETQPFSLVKTTEAAETLETTISEAYSEIRETKAVGSQPHPLEEREVLVEETKAFLPVDLPYHDEINEPSLPKEGNLVLEKSSRDVVTHSEEKGQVIVSELPKAGSVGTTEESKQGSPSKESERILDRPFGETKSLETPSYLLSSVKPQTLTSEASPEVSPEKKQELPWSEVTPHRPTVHTTQTSKDQTSEMFEQPVLVSKHHLEAVEDSQVYEPCPSASSNYAQFITNASTISADEVVSKEPEDTSVRDEEFTVTSKPAGLSEEQKSAFSIISEGCEILNIHAPAFISSVDQEESEQMQDKLEYLEEKISFKPILLRDESEEVACHKTLQSKLEDSDIKVISLKEDQQKEIHTTKEEIPTDSETGDLAFNQPTSPDEEDYFEKYTLIDYNIFPDPEKQSAPWKLEAGLSKEVPEETVSFPEHSEEGALEHEYDLVKLDESFYGLEKDYSKLSDPETQKSLVIQKLTDRDAPKSTDRDVGSKSPGMPLFDEEEGVLSRTQIFPTTAKAINPELLEEPPALAFLYKDLYEEAVGEKKKEGETASEGDSVNSEASFPSRNSDTDDGTGIYFEKYILKDDILHDTCVTEKDQGQGLEEKPIDKDDSYQPITAEGEIWGKFATIGREESLEEKQKAAYREGESVGHMETLDNVAMQRKAPITEEVRVVTQRISYAVPFEDTHHVLERVDETSSQTNEAANANPEVSLNVPVQVSFPEEEFASGATCMQEILQEEPQIMVPPEPSEDWVRSSPVQDEYEFAESLNYEVVTQDTLSEDLYSESTPEDVLSQGKESFEHVSENELVTEAEQRKSAEQKELDIEMAEQDQLLSELVTEKEQKEMKTSQIDTYCYTCKSPISAVDKMLGTHKDHEISTLDTAISAVKVQLADFLEDLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQSFEEVKRKKMEFLHDQMVHFLQSMDTAKDTLETIVREAEELDETVFLTNYFPNRLLSAMENTASLEKMPAAFSLFEHYDDSSARSDQMLKQVAVPQPPRLEPQELNSATSTTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNDLVEEYRVTVKESYCVFEDLEPDRCYQVWVMAVNFTGCSLPSERAIFRTAPSTPVIRAEDCTVCWNTATIRWRPASPEATETYTLEYCRQHAPEGEGLRSFSGIKGLQLKVNLQPNDNYFFYVRAINAFGTSEQSEAALISTRGTRFLLLRETAHPALQISSNGTVISFAERRRLTEIPSVLGEELPACGQHYWETTVTDCPAYRLGVCSSSAVQAGALAQGETSWYMHCSEPQRYTFFYSGIVSDVHVTERPARVGILLDYTTQRLLFINAETGQMLFIIRHRFNEGVHPAFALEKPGKCTLHLGIEPPDSARQK", "length": 3986, "header": "tr|A0A3Q1MLM4-1|F1ME62_BOVIN Computationally mapped isoform of Cardiomyopathy-associated protein 5 OS=Bos taurus OX=9913 GN=CMYA5 PE=4 SV=2 CANONICAL=F1ME62-1" }, "locus": { "chromosome": "10", "start_pos": 10772777, "end_pos": 10675370, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075459.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075459.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072607.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072607.2" } ] } }, { "isoform_ac": "F1ME62-1", "url": "https://www.uniprot.org/uniprotkb/F1ME62/entry", "sequence": { "sequence": "MASSDGSHAAESALGADEEETRAPDAEEQSGGEEDESAVESESESESEPDARLSDQDEEGKTEKKCIISDPSFSMVTVQQEDSGITWETSSSRPSTPWASEESQTSGVCSLEGSTLNSPPGNVSFILDEVKKVRKRKPKSKHGSPSLRRKGNKKRNSFESQDVPANKTSTPLISESQELTTQKDKSSTGAYDKMRKKKSTSSTPPITGAIYKEYKPLVLRPVYIGTVQYKIKMFNSVKEELIPLQFYGTLPKGYVIKEIHYRKGKEASISLEPESGNCDLKVVSKTGKSVAQSIEDVKVKELAPPWRDAFSKGSKSLTSLFSHEDQKKTYDDFPLRAASAAQHTASSHTSHAIAERESQLSPPRVVPRLLVDEAKPREMKPSFLTPDTSVATFLETAKEESEADSQEIVIAEPDSSASPPVLDEVKTEDMSSVDHSISLEAEKGSLESGAPGLTASIQEDFSPERDKLDLTSRERVEPVTDQLTPPHLIIKGGKGETVPEPSISLFEPLVLEEPEKEEIEMPLPMAATPEPEDSNLVEEEIIELDYPESPSVSEEPFPPRLAPEVEEKEETPLPLLTTSTPEHVTLSEEEREENESVSTDSAFVSEYSAPQDWNYELEKQEAEPVSLPHVKAVSEHAVLSEEEDDKFEPSSPTSASIFVSPSTTEKTLECQSPLFSAVTPEPMILSGEEASESGHYTPDSTSASEYLVPSQATEESPKKTVDLKSPLKSQGVSEPLILSEEENEDPGLCSPEVASLSERSVSPHTTEGTSEGQAPLLSAVTSEHAILSEEENLGNEGVTRDSALTFQNAVPPNVRQESPKNIIDDVSLLKSEGVSEHKTVLEEEKEDAGFYTPEVASLPEGFLPPSTTEGTPECQVPRLSVAPPDHVVLSEEETVEMERYTPSSTSASELSEPPYATPESQEEEIVHTSPLNLKGSSSPMIFSEEEQEDIGPFSPDSAFVSEFSFPPYATTGKREFECDSPICLTSPSEHTILSDEDTEETELFSPDSASQASIPPYRIPEMNKKEIEPDSLLTAMAASGYPRFSEADEEEIAPTTTTPVPEHLSSLQKQRAEPSVSAPEDLSQLPSTNEAEKAEIKPDAQTTSASVSEYLILAQKQRTQTYLEPEPEDSIPPSLTSDSERGETKSSSSLAAAPAVKEVPTVKEETKPVLPASQCSVSPDSVHAIKKEQEPQTSLTPKSADEQMALLKVESKEEIVPDSQEAIAHVLQDQEMEPQPPNVPDSGMKDSVLPDLADEPKKDVKPNLAPTLTSELEQRRLSEKEPEVTKPYSPLKETSLSRPEISSVVKTEVKLDSKVTGTPRVLRSASPGVEQEVEHGPPVPEFEFSALSEEIKKEIEPSSSITATSETKHDSNLTKLAKEEIPKNLPLTTPIEHQVLTKGEKSELGSGLPPVDEHSLFKEDKVAIKASPSPTETAASQYPAWSEVEKEIKFDLPASISSISEHSVLSKVETEDIKPGLAITKTLSSQHSDVSKEARVEDKQDLSFPTVLDSEYLDLSQKKISVSASEMSGPEHVPSLSLGGEIKKTETELPSSQNMSPAPKYIVPKGKDEVTASSVPELKHLTSEDLASTFLTFSGDKREQAVETPSVIQGDFRSEKAGLALAQLSLEPEKRDKTHPVSEFPDTGNAGSEFAGDVNRQSGSIQTEHIKSPLPETENSALEKGLPELRSRGEGKEENRELHVSTTVPKISEVSSYLREEPQIQEMKSLSAKVVSLGSREAFTSQLEGDSLEEFQSHTLSSKGLSEELNRSADFKKEEKQEISPLQPAGNLKAQETEDTVTKPNETDQPNSFHVLQSITEPSNITSSDLFVQQKPEEAFVSDQAATLPEISRSFADKQDLGIKQVLFMKENLPLEESKLFMTTEPTNVRETHMKEALISPKDENWMLKEPEGDLVSHHEERAMESVQLDHSGTNDLMTGQLKPALPEKDHMPEIRKQILPPSAEEPHIAFQEPVSTLDTSRDNVETLATETYSSEDIKLAPKPKSLVPAGNVERSEAEGKQTLSFVGGESLVVEKANTEISRPCKEGSQEEIKTPYEGGLQKPVSGPSVEQVKSETPPSLVKAARALAEEAEPALGVEKEAHGRISPLPGEKPLEESNVVQPKVADDANERGKPPSEVKAPTQIKPLSSTQENEEPQPLESPEVIQKPPKQQKAVEPSISEEKGKKGISSFTSWVSSFFFRSSTLDNEVAEKEDLEAQPSPSEEKTVTVIDSEGPAPADVHGTEKPVSHLFLEAKRETASESAGSLVKSGEHQDFKEKPALLSDVEVSPQPKSNFEASSDDYGKKEVLDYSGEMDLTSVVTSADGEGHLRIQSDSPMGEKSIMEEAKNAVPLHVTDSKRLQKPEISPRSKWNISILKEEPRSDQKEKTLFLVDATDKVPQQPESGSSSFASKDITEESEKLESIILPGEEPKGSLIDLGEDRLGKEMPKPVSLKISEEEVKLRSVSPAEEKGNLGMRSYSLAEKKVLAEKQEIAAPLEHRDINEIEKAKIIHGPSPVKLEEPKAATVLQQVYQNEDHKERYKIIEEEKGEEKEERSHAFSEGREQEIQPYSISIAGHPPEESDISFHLTLGETQPFSLVKTTEAAETLETTISEAYSEIRETKAVGSQPHPLEEREVLVEETKAFLPVDLPYHDEINEPSLPKEGNLVLEKSSRDVVTHSEEKGQVIVSELPKAGSVGTTEESKQGSPSKESERILDRPFGETKSLETPSYLLSSVKPQTLTSEASPEVSPEKKQELPWSEVTPHRPTVHTTQTSKDQTSEMFEQPVLVSKHHLEAVEDSQVYEPCPSASSNYAQFITNASTISADEVVSKEPEDTSVRDEEFTVTSKPAGLSEEQKSAFSIISEGCEILNIHAPAFISSVDQEESEQMQDKLEYLEEKISFKPILLRDESEEVACHKTLQSKLEDSDIKVISLKEDQQKEIHTTKEEIPTDSETGDLAFNQPTSPDEEDYFEKYTLIDYNIFPDPEKQSAPWKLEAGLSKEVPEETVSFPEHSEEGALEHEYDLVKLDESFYGLEKDYSKLSDPETQKSLVIQKLTDRDAPKSTDRDVGSKSPGMPLFDEEEGVLSRTQIFPTTAKAINPELLEEPPALAFLYKDLYEEAVGEKKKEGETASEGDSVNSEASFPSRNSDTDDGTGIYFEKYILKDDILHDTCVTEKDQGQGLEEKPIDKDDSYQPITAEGEIWGKFATIGREESLEEKQKAAYREGESVGHMETLDNVAMQRKAPITEEVRVVTQRISYAVPFEDTHHVLERVDETSSQTNEAANANPEVSLNVPVQVSFPEEEFASGATCMQEILQEEPQIMVPPEPSEDWVRSSPVQDEYEFAESLNYEVVTQDTLSEDLYSESTPEDVLSQGKESFEHVSENELVTEAEQRKSAEQKELDIEMAEQDQLLSELVTEKEQKEMKTSQIDTYCYTCKSPISAVDKMLGTHKDHEISTLDTAISAVKVQLADFLEDLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQSFEEVKRKKMEFLHDQMVHFLQSMDTAKDTLETIVREAEELDETVFLTSFEEINERLLSAMENTASLEKMPAAFSLFEHYDDSSARSDQMLKQVAVPQPPRLEPQELNSATSTTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNDLVEEYRVTVKESYCVFEDLEPDRCYQVWVMAVNFTGCSLPSERAIFRTAPSTPVIRAEDCTVCWNTATIRWRPASPEATETYTLEYCRQHAPEGEGLRSFSGIKGLQLKVNLQPNDNYFFYVRAINAFGTSEQSEAALISTRGTRFLLLRETAHPALQISSNGTVISFAERRRLTEIPSVLGEELPACGQHYWETTVTDCPAYRLGVCSSSAVQAGALAQGETSWYMHCSEPQRYTFFYSGIVSDVHVTERPARVGILLDYTTQRLLFINAETGQMLFIIRHRFNEGVHPAFALEKPGKCTLHLGIEPPDSARQK", "length": 3988, "header": "tr|F1ME62-1|F1ME62_BOVIN Isoform 1 of Cardiomyopathy-associated protein 5 OS=Bos taurus OX=9913 GN=CMYA5 PE=4 SV=3 CANONICAL=F1ME62-1" }, "locus": { "chromosome": "10", "start_pos": 10772777, "end_pos": 10675370, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008967.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008967.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008967.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008967.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 917, "start_aa": "Thr", "end_pos": 917, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr917", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "M0R557-1", "protein_name": "Cardiomyopathy-associated protein 5", "gene_name": "Cmya5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASSDSGLAAQGLLGWGAEEEEPETEEESEGEGEETAAESEEEPDARLSDEDEEGKIKQECIISDPSFSMVAVQREDSGITWETNSSRSSTPWASEESQTSGICSLEGSALTSPPGSVSFIMDEVKRTRKRTQKSKRGSPSLRRKGSKKRNSLESQDVLTNQEDGPLISEKPVLNTEKEKSSIGTYDKTRRKKTESNTPPITGAIYKEHKPLVLKPVYIGTVQYKIKMFNSVKEELIPLQFYGTLPKGYVIKEIHYRRGKESSISLEPDLSNGGSNIASQRKLAQSPEEDRARELAPPWRGALSKGSMTSLFSHEEQKKTYTDSLLNATSSTEHTLPSYSRNDTADQEEHLRPSQTVQQQPADESKTYRTEPPSTPATMVPERAKEELEQNSQGMESSEDASGLSGLANDVEQEGMVSVNHSMSWEAEKESLKTGPSRPGPAIQEGFEPDMEELEPISREKMEPVSEPVTSSEPIDHREEEHAPEPIDHREEEHAPEPLVHREEEHAPEPLVHREEEHAPEPIVHREEEHAPEPIVHREEEHAPEPIVHREEEHAPEPIDHREEHAPEPLVHREEEHAPEPLVHREEEHAPEPIVHREQEHAPEPIVHREKHAPEPIVHREEEHAPEPIVRREEEHAPEPIVHREEEHAPEPLVHREKHAPEPIVHREEEHAPEPIVHREEEHAPEPLLSLASQEVESGAETSLPITDTIEPEDSSLEEEIIELDYPESPLVSEKDSPLPLSPEVEHRKEPILPSQMTFTPEHITLSEEEREESESVSTDSAFVSEYSVLQDLNRKSEKLEVEAVSVSDVKSSEPAVFSEDEEERESYSPAVTSVSEHSLSPSTTEKTSSTQSPLFSTVSPDNLVLSGDEASETEASDSLSATEYSGPAHVQELLVRAGDPKLPLKSQHVSEPIIQTEDEKEDIGLLSSAVDATSEYPHSPSLSEKASECHLPPLATTLRHAALSEDEGLESGSFVSDSKLPFKPSVPQSATQEPPEKTGDDTPQFKPKGLAEPTILLEEEKEAIELSSSSEVPAAERTLPPQTTELLSESQAPPSWPTSSEQEGLSEERSGEGQQRSFSSTPELVHTSPLLLKGASSPSALSEPGQEEDSIGPLSPDSAFASEFSFSPYPTQELERRELGRDSPLCLTSPSEHTVLSDEDTEEAELFSPDSASQVSIPPYRIAETERNKVEADELLPMSPVPDFPYFSGADEEETGSSVATPVPEHSAPSKERKEEPFPSIPVFEDLSLPPSAVMTTTGQAETKPDVPTVSTSVSEYLILAQRQKTQASLEPEAEDVVPPPLTSGWEETDAKSSSTASTIAASASAVSSVVKEETASILSTSQFSVSPESARVPKTEREPKASLTLTSAEEQMALPKVRREEIVPDSQEATAHKSQDQTPEPQPPNVPGSGMRYSVLSDMGDEPKADVKPDLAPAVTSELEQRMLSKNEPEVVKPHSPPEETSISGRKVLSAVQKEVKQESKITRELPAASSGIEREVEHHPPAPTALPALREETERETKASVSATPVPVTKLDSNSAALGRDEILTDSSLAGPAEHPGFKGVGERGLGSGEPSLTMSAADPTVLRAGEKEPIKEAAAVLDSSSFRGSAWPEAEEKGRLESSLSLSSPSELSDWSKVETEEVKRGWPGAKVPSDVAAETGVEDKRGISLSPAPESKESTSPQKKNLVSVSEVLRPEPKLPIDLWSEVEREDTEPPPSQVSPTPKHTVPDDKPEEMTRSPDSENLVSDDLAPTLLALRDEMNGQAEETSSPVLGSFLSGKEELVKLPPEPKKPKRFSEAPTVGLELTDSRDRDGSLGIEIVKPSVLEKGPTELRSAGKEQEEHRGLPVPATSPLETASSDLPIKQKELKKTLPEGQAVKVPDVGSSFAEKPDLGIKQLAQRKENLEQPKPFMTAEPADVIGTEVKETLISPKDNTRMLDKPDGLVSQHEDRKPGPRQLESSESKDLMPEKLGAAPLDSDHTPGIRKQEEPHLPLQEQASILRVSSGKVETFTTKTYLSEETEAVVPVGKTDRGRAEERQNSSFMESENSVSEKTNAEFPKPCKEDVQMELKLPLGRTIQKSGTGPSVEQATPIPASSAHFLAEVVEPTVGKNQEASIAPVSGEKPSQEPTRVQSKAVGDAEEGRKLAPDVQVPAVKANVAPQPPETPGVTQKPSEKSLVAEQCLPAEKGKKGISSFKSWMSSLLFGSSTPDNKVADNKDLETQPSPSLEKALTAVEPKGAVPAEVTVAEKPGVHSLPEVTVKLGEEPRGGEKLTFLPNTDVLKQPASNSENYGKKGLPGFSEGMGENLATSAGDEHPGIHPRSPMGEKVGMEEAQNTAPLHVTESQRHQKPEIAPPSMWSISVLKEEPSSGHKEAQLLSSDVVDRTPQRPESTLSAFARMDSEKQAPVSLPVESEDSLIDLGEDRLRQEMPKPTSLERHEEEVERPAVEKDGWGTRSFSLAGEKGLAEKQEIMAPLEVGENKAVGKLQMMPESRPFKSEGSKAAERLEQRISPREELMEKPSKTLASERREKEAQERVFPEGEKEGGLSSSPAAAMPVPGASAISWDKAQPPSPVKPPPVIEKPEHIFTEVYPEIGERKAAETKPHPQEEGKTLVEKTKASRVEPPHGEEVDGHSFTQGGNLELEKSRESRVDLKEERRQFVMPELSLAASVAAEDGHAQPRPLSRAAERTAGHITDETNNLGPPTLETSLEQTAKKQETRSDRPTVHTIQTSKDHPEEMPKQSVLISKRHLEAMEDVHRNEPLSSAASSYTQFMLSASAVSADGAPPVGGTPQEPEGTSGKGEEFSVTSKPAGLSEEQKSAFSIISEGCEILNIHAPAFIPSVDQEESEQMQDNLQYLEEKSSFKSISVCDERKAVASHKTQKSELEVPDRKITSPTENEPKESYQTKEETATGSRSGDFTSIQPGVSGEEDYFEKYTLIDYNLSPGSERQKSTVEGSSEEATETLTSFPESSAEQTLDHEYDLVKLDESFYGPEKNGSKSSHAEMPKSLVIQKPSEENAPKGVGVDVDSRSPGMPLFDVEEGVLSRRQIFPTTPKAVNPELLEEPPALSFFYKDLYEGALGEKNEGETASEGGSVDSETSFPRRHSDTDDGTGMYFEKYVLKDDILHDESVNQEDQGQSLEEKPVGENGSQQLRIAESEIGRKPGTSFWERNLEEQHKVIDREGEPVSHTETLNEVATQQKAPVTEQVTAITQEMSYAVPFQDTHRVRTSEPSSQGHEAGNASPEVNLNVPVQVSFPEEESTAGATYAPEVSQEELVPCVSREERLHNIPVQDEYDFVDSLNQEIVSQGILPGEPYSEAPPKEVLPQGTESLSHAGERELMSEGEPRKSASQEEWDRGGEDQSARESVTTKTQKEQKKAQVDSYCYTCKSLVSEMDKVLDIHKHHEVSALDTAISAVKVQLGEFLENLQEKSLRIEAFVSEIESFFNTIEEKCSKNEKRLEMQNEEMMKKVLAQYDEKAQSFEEVKKKKMEFLHDQMVHFLQSMDTAKDTLETIVREAEELDETVFLASFEEINERLLSAMESTASLENMPAAFSLFEHYDDSSARGDQMLKQVAVPQPPRLEPQEPNSATSTTIAVYWSVNKEDVVDSFQVYCVEEPQDDQEINELVEEYRLTVKESCCIFEDLEPDRCYQVWVMAVNFTGCSLPSERAIFRTAPFTPVIHVEDCTVCWNTATVRWRPANPEATETYTLEYCRQHSPEGEGLRSFSGIKGLQLKVNLSPNDNYFFYVRATNASGTSEQSEAALISTRGTRFLLLRETAHPALQISSNGTVISFSERRRLTEIPSVLGEELPACGQHYWETTVTDSPAYRLGICSSSAVRAGALGQGESSWYMHCSEPQRYTFFYSGIVSEVHATERPARVGILLDYTNQRLLFVNAESGQLLFTVRHRFNEGVHPAFALEKPGKCTLHLGLEPPDSVRHK", "length": 3943 }, "evidence": [ { "id": "F1ME62", "url": "https://omabrowser.org/oma/group/F1ME62/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q70KF4-1", "protein_name": "Cardiomyopathy-associated protein 5", "gene_name": "Cmya5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESGDSGLAAQGFLGWGADEEVAQELETEEESEGEGEETAAESEEEPDARLSDEDEEGKTKQECIVSDPSFSMVAVQREDSGITWETNSSRSSTPWASGESQTSGICSLEGSALTSPPGSVSFIMDEVKRTRKRTQKSKRGSPSLRRKGSKKRNSLESQDVLTNQEDGPSISESPVLNIENEKSSIGTYDKTRRKKTASNTPPITGAIYKEHKPLVLKPVYIGTVQYKIKMFNSVKEELIPLQFYGTLPKGYVIKEIHYRRGKDSSISLEPDLSNGGSNIVPQRKLAQSPEEDKVRELAPPWRGALSKGSRTSLFSHEEQKKTYADSNLNVPSSTEHAFPSSARNDTADQEENLSLPQMMPQQPADESKTHRMEPPSIPATMVLERAKEELEQNAQGKESSEDDASVLTGSADDVQQEGLVSVNHSMPWEAEKESLETGPPRPAPAIQEKFEPDMEGLEPISTEKTEQASEYVTSSEPIVHREEEHAPEPIVHREEEHAPEPIVHREEEHAPEPESIVHREEEHAPESIVHREEEHAPEPVPIVHREEEHAPEPESIVHREEEHAPEPIVHRDKGHALEPIVHREEEHAPEPIVHRDEGHAPEPIVHREEEHVPEPESIVRKGEEHAPEPIVHREEEQVPEPESIVHREEEHAPEPIVHREEEQVPEPESIVHREEEHAPEPMVLREEHAPEPIVRREEEHAPEPIVHREEEHAPEPMVHRKAQQLERGVETSTPITDITEPEDSSLEEEIIELDYPESPLASKETSPSPLSPEVEHRKEPILPTQMTFTPERITLSEEEREENESVSTDSAFVSEYSVLQDLNHTPEKLEVEAVSVSDVKSSNEPAVFSEDDEERESYSPAMTSVSEQSLSPSTTEKTSAIQSPLFSTVSPVLSGDEASENVCHSPESESAAEYSVPAHAQELLLKTGDHKLPLKSQRVSEPIIQAEDEKEDIGLLPPAALSQAVLSEDESLGSGSFASDSKLPFKPSVSQNATRESPQKTIDDMPQFKPRGLSDPATLLEEEKEAIGVGLSSSNEVSAVECALPPQTTELLSESHAPPPWAISSEQVVQSEEGSRDQQRGSFSSTPELGHTSLLLKGASSPTGLSEQGQEEDNIGPLSPDSAFASEFSFSPYPTQELEKRELGRDSPLCLTSPSEQTVLSEEDTEEADLFSPDSASQVSIPPYRIAETEQNKVEPDELLPTRSAPDYPYFSEADEEEAGSSVVTLVPEHSEPSQEREESSPCRPVFEDLSLPPSADKTGQAETMSDVPTISTSVSEYLILARQAKTQASLEPEAEDLVPPPTSGWEKRDAKSSLPAVTIAASSSALSSVVKEETTSVLPTSQPSVSPESTCVLKPEQEPTAPLTLTSADEQMALPRVGREKAVLDSQEATAHKSQDQTPEPRLPNVPGSGMKYSVLSDLGDEPKADVKLNLAPTVTSELEQRMLSKNEPEVAKPHSPPEETSISGPKVLSAVKTEVKQESKITRELPAASSGRERGAEHSPPVPPALPALTEETGKDTEASSSATTVPVTKLDSNSTKLGRDEVLTDPSLASPVEHPGLKGIGKSELGSGLPLPSMSASEVLRPEPKLPVNSGVEVEREDNEPPPLQVSPTSKPTVPNDKHEEITRSPDSENLVSDDLAPTLLAFRHEMNRQAEETSSPVPGSFLSGEQELIKLPPEPEKHKQLSEVPTAGSELIDSRDRDRSLGIEPVKPIGTEPGPSILEKGPAELQRRGKEQEENRKLPVPASAPLETASFDLPIEQKEPKRTLHEGQAVEVPDESSSSADKPELGVKQLAEKKENLEQPKPFVTTERASVTGSKVKESLISPKDNIWMLEKPDGLVNQHEDRKPGTGQLESSESTDLMSEKLGAASLDTDHTSETRNQETSKAPVSGEKLSQEPRRVQSKAVDDSEEGRKLASGNVEVLTQSKSVPAVKAKATPQPPETPEVTQKPSEKSLVTEQGLPAEKGKKGISSFKSWMSSLLFGSSIPDSKVSDNEDLETRPGPSVEKAVPAIEPKGTVPAEVNIAEKPAVHSLPEVTVKLAEEPKGVSVKSSISQDLKEKLTFLSNEDVLKQPKSNSENYGQKELPGFSEGMGESLATSVGDKHPGIHPCSPMGEKVGMEEAQNMAPLHITESQRRQKPEVSPPSMWNISARKEEPSSDHKETWLSSSDVVDRMPQKPKSAQSAFTRMNSEEPASMILPVESKGSLSDLGEDRLRQEMPKPTSLEHCEEEVERPTEEKDGWETRSFSLAGKRGLAEKQEIMAPLELRENEAVGELQRMPESRPFKLEESKAAERLEQRISPTEKLMEKPSKTLALDRREKEVQEWVFSEGEKQEYPPAAMPVPGASAVSLDKAQPHLLAKPTPVVEKPEHIVTEVYPEIRERKAAETQPHPQEEGKTLVEKTKVSRVESPHGEETDGHSLTQEGNLELEKSGESRVDLKEERRRFVMPELPLGASVAAEDGSVQPRPLSKDAARASDMTDETKHLGTPPTQPSAVEPQTLVLGTSVEHAVKKQETWSDRPTVHTFQTSKDDTEEMLKQSVLISKHHLEAVEDVHRNEPPSSAASNYAQFMLSASEISADGVPPMGGTAQEPEGTSVKDEEFSVTSKPAGLSEDQKSAFSIISEGCEILNIHAPAFIPSVDQEESEQMQDKLQYLEEKASFKSISVHDEKKAAASHKTQKSKLEVPDRKITSLKENKTKETHKTKEEIATDSGMGDFTPIQPTVSGEEDYFEKYTLIDYNLSPGSGKQKSTVEESSEEATKTLTSFPESSAEQALDHEYNLVKLDESFYGPEKDDSKLSHAEMQKSLAIQKPDDRNAPKGISRDVDSRSPGMPLFDVEEGVLSKRQIFPTTPKAVNPELLEEPPALSFFYKDLYEGACGEKNEGETASEGDSVDSETSFPRRHSDTDDGPGMYFEKYILKDDILHDESVTQEDQGQGLEEKPVGEEDSQQLRVAEREIRRKPETSFWEKNLEEQHKVVGREGEPTGHMETLDEAAMQQKAPITEQVRAVTQKMSYAVPFQDTRCVLESEPSSQGNEAGNASPDVNLNVPVQVSFPEEESAAGATYAPEVLQERLVPSVSREERLHNTPVQDEYDFVGSLNQEAASQAILPEEPGSESSPKEVLSQGSESFEHIREQELTSEGEPRMSASQEVWDRTEDQSARESVTAKTQKEPKKTQAESYCYTCKSLVSEMDKALDIHKDHEVSALDTAISAVKVQLGEFLENLQEKSLRIEAFVSEIESFFNTIEEKCSKNEKRLEMQNEEMMKRVLAQYDEKAQSFEEVKKKKMEFLHDQMVHFLQSMDTAKDTLETIVREAEELDETVFLASFEEINERLLSAMESTASLENMPAAFSLFEHYDDSSARSDQMLKQVAVPQPPRLEPQEPSSATSTTIAVYWSVNKEDVVDSFQVYCVEEPQDDQEINELVEEYRLTVKESCCIFEDLEPDRCYQVWVMAVNFTGCSLPSERAIFRTAPSTPVIHVEDCTVCWNTATVRWRPANPEATETYTLEYCRQHSPEGEGLRSFSGIKGHQLKVNLPPNDNYFFYVRATNASGTSEQSEAALISTRGTRFLLLRETAHPALQISANGTVISFSERRRLTEIPSVLGEELPACGQHYWETTVADSPAYRLGICTSSAVRAGALGQGETSWYMHCSEPQRYTFFYSGIVSEVHATERPARVGILLDYTNQRLLFINAESGQLLFIVRHRFNEGVHPAFALEKPGRCTLHLGLEPPDSVRHK", "length": 3739 }, "evidence": [ { "id": "F1ME62", "url": "https://omabrowser.org/oma/group/F1ME62/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N3K9-1", "protein_name": "Cardiomyopathy-associated protein 5", "gene_name": "CMYA5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASRDSNHAGESFLGSDGDEEATRELETEEESEGEEDETAAESEEEPDSRLSDQDEEGKIKQEYIISDPSFSMVTVQREDSGITWETNSSRSSTPWASEESQTSGVCSREGSTVNSPPGNVSFIVDEVKKVRKRTHKSKHGSPSLRRKGNRKRNSFESQDVPTNKKGSPLTSASQVLTTEKEKSYTGIYDKARKKKTTSNTPPITGAIYKEHKPLVLRPVYIGTVQYKIKMFNSVKEELIPLQFYGTLPKGYVIKEIHYRKGKDASISLEPDLDNSGSNTVSKTRKLVAQSIEDKVKEVFPPWRGALSKGSESLTLMFSHEDQKKIYADSPLNATSALEHTVPSYSSSGRAEQGIQLRHSQSVPQQPEDEAKPHEVEPPSVTPDTPATMFLRTTKEECELASPGTAASENDSSVSPSFANEVKKEDVYSAHHSISLEAASPGLAASTQDGLDPDQEQPDLTSIERAEPVSAKLTPTHPSVKGEKEENMLEPSISLSEPLMLEEPEKEEIETSLPIAITPEPEDSNLVEEEIVELDYPESPLVSEKPFPPHMSPEVEHKEEELILPLLAASSPEHVALSEEEREEIASVSTGSAFVSEYSVPQDLNHELQEQEGEPVPPSNVEAIAEHAVLSEEENEEFEAYSPAAAPTSESSLSPSTTEKTSENQSPLFSTVTPEYMVLSGDEASESGCYTPDSTSASEYSVPSLATKESLKKTIDRKSPLILKGVSEYMIPSEEKEDTGSFTPAVAPASEPSLSPSTTEKTSECQSPLPSTATSEHVVPSEGEDLGSERFTPDSKLISKYAAPLNATQESQKKIINEASQFKPKGISEHTVLSVDGKEVIGPSSPDLVVASEHSFPPHTTEMTSECQAPPLSATPSEYVVLSDEEAVELERYTPSSTSASEFSVPPYATPEAQEEEIVHRSLNLKGASSPMNLSEEDQEDIGPFSPDSAFVSEFSFPPYATQEAEKREFECDSPICLTSPSEHTILSDEDTEEAELFSPDSASQVSIPPFRISETEKNELEPDSLLTAVSASGYSCFSEADEEDIGSTAATPVSEQFSSSQKQKAETFPLMSPLEDLSLPPSTDKSEKAEIKPEIPTTSTSVSEYLILAQKQKTQAYLEPESEDLIPSHLTSEVEKGEREASSSVAAIPAALPAQSSIVKEETKPASPHSVLPDSVPAIKKEQEPTAALTLKAADEQMALSKVRKEEIVPDSQEATAHVSQDQKMEPQPPNVPESEMKYSVLPDMVDEPKKGVKPKLVLNVTSELEQRKLSKNEPEVIKPYSPLKETSLSGPEALSAVKMEMKHDSKITTTPIVLHSASSGVEKQVEHGPPALAFSALSEEIKKEIEPSSSTTTASVTKLDSNLTRAVKEEIPTDSSLITPVDRPVLTKVGKGELGSGLPPLVTSADEHSVLAEEDKVAIKGASPIETSSKHLAWSEAEKEIKFDSLPSVSSIAEHSVLSEVEAKEVKAGLPVIKTSSSQHSDKSEEARVEDKQDLLFSTVCDSERLVSSQKKSLMSTSEVLEPEHELPLSLWGEIKKKETELPSSQNVSPASKHIIPKGKDEETASSSPELENLASGLAPTLLLLSDDKNKPAVEVSSTAQGDFPSEKQDVALAELSLEPEKKDKPHQPLELPNAGSEFSSDLGRQSGSIGTKQAKSPITETEDSVLEKGPAELRSREGKEENRELCASSTMPAISELSSLLREESQNEEIKPFSPKIISLESKEPPASVAEGGNPEEFQPFTFSLKGLSEEVSHPADFKKGGNQEIGPLPPTGNLKAQVMGDILDKLSEETGHPNSSQVLQSITEPSKIAPSDLLVEQKKTEKALHSDQTVKLPDVSTSSEDKQDLGIKQFSLMRENLPLEQSKSFMTTKPADVKETKMEEFFISPKDENWMLGKPENVASQHEQRIAGSVQLDSSSSNELRPGQLKAAVSSKDHTCEVRKQVLPHSAEESHLSSQEAVSALDTSSGNTETLSSKSYSSEEVKLAEEPKSLVLAGNVERNIAEGKEIHSLMESESLLLEKANTELSWPSKEDSQEKIKLPPERFFQKPVSGLSVEQVKSETISSSVKTAHFPAEGVEPALGNEKEAHRSTPPFPEEKPLEESKMVQSKVIDDADEGKKPSPEVKIPTQRKPISSIHAREPQSPESPEVTQNPPTQPKVAKPDLPEEKGKKGISSFKSWMSSLFFGSSTPDNKVAEQEDLETQPSPSVEKAVTVIDPEGTIPTNFNVAEKPADHSLSEVKLKTADEPRGTLVKSGDGQNVKEKSMILSNVEDLQQPKFISEVSREDYGKKEISGDSEEMNINSVVTSADGENLEIQSYSLIGEKLVMEEAKTIVPPHVTDSKRVQKPAIAPPSKWNISIFKEEPRSDQKQKSLLSFDVVDKVPQQPKSASSNFASKNITKESEKPESIILPVEESKGSLIDFSEDRLKKEMQNPTSLKISEEETKLRSVSPTEKKDNLENRSYTLAEKKVLAEKQNSVAPLELRDSNEIGKTQITLGSRSTELKESKADAMPQHFYQNEDYNERPKIIVGSEKEKGEEKENQVYVLSEGKKQQEHQPYSVNVAESMSRESDISLGHSLGETQSFSLVKATSVTEKSEAMLAEAHPEIREAKAVGTQPHPLEESKVLVEKTKTFLPVALSCRDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFRESELSKGGSVDITKETVKQGFQEKAVGTQPRPLEESKVLVEKTKTFLPVVLSCHDEIENHSLSQEGNLVLEKSSRDMPDHSEEKEQFKESELWKGGSVDITKESMKEGFPSKESERTLARPFDETKSSETPPYLLSPVKPQTLASGASPEINAVKKKEMPRSELTPERHTVHTIQTSKDDTSDVPKQSVLVSKHHLEAAEDTRVKEPLSSAKSNYAQFISNTSASNADKMVSNKEMPKEPEDTYAKGEDFTVTSKPAGLSEDQKTAFSIISEGCEILNIHAPAFISSIDQEESEQMQDKLEYLEEKASFKTIPLPDDSETVACHKTLKSRLEDEKVTPLKENKQKETHKTKEEISTDSETDLSFIQPTIPSEEDYFEKYTLIDYNISPDPEKQKAPQKLNVEEKLSKEVTEETISFPVSSVESALEHEYDLVKLDESFYGPEKGHNILSHPETQSQNSADRNVSKDTKRDVDSKSPGMPLFEAEEGVLSRTQIFPTTIKVIDPEFLEEPPALAFLYKDLYEEAVGEKKKEEETASEGDSVNSEASFPSRNSDTDDGTGIYFEKYILKDDILHDTSLTQKDQGQGLEEKRVGKDDSYQPIAAEGEIWGKFGTICREKSLEEQKGVYGEGESVDHVETVGNVAMQKKAPITEDVRVATQKISYAVPFEDTHHVLERADEAGSHGNEVGNASPEVNLNVPVQVSFPEEEFASGATHVQETSLEEPKILVPPEPSEERLRNSPVQDEYEFTESLHNEVVPQDILSEELSSESTPEDVLSQGKESFEHISENEFASEAEQSTPAEQKELGSERKEEDQLSSEVVTEKAQKELKKSQIDTYCYTCKCPISATDKVFGTHKDHEVSTLDTAISAVKVQLAEFLENLQEKSLRIEAFVSEIESFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQSFEEVKKKKMEFLHEQMVHFLQSMDTAKDTLETIVREAEELDEAVFLTSFEEINERLLSAMESTASLEKMPAAFSLFEHYDDSSARSDQMLKQVAVPQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLTVKESYCIFEDLEPDRCYQVWVMAVNFTGCSLPSERAIFRTAPSTPVIRAEDCTVCWNTATIRWRPTTPEATETYTLEYCRQHSPEGEGLRSFSGIKGLQLKVNLQPNDNYFFYVRAINAFGTSEQSEAALISTRGTRFLLLRETAHPALHISSSGTVISFGERRRLTEIPSVLGEELPSCGQHYWETTVTDCPAYRLGICSSSAVQAGALGQGETSWYMHCSEPQRYTFFYSGIVSDVHVTERPARVGILLDYNNQRLIFINAESEQLLFIIRHRFNEGVHPAFALEKPGKCTLHLGIEPPDSVRHK", "length": 4069 }, "evidence": [ { "id": "F1ME62", "url": "https://omabrowser.org/oma/group/F1ME62/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1ME62", "url": "https://www.uniprot.org/uniprotkb/F1ME62" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1ME62", "url": "https://www.uniprot.org/uniprotkb/F1ME62" } ], "pmid": "" }, { "name": "M band", "id": "GO:0031430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031430", "evidence": [ { "database": "UniProtKB", "id": "F1ME62", "url": "https://www.uniprot.org/uniprotkb/F1ME62" } ], "pmid": "" }, { "name": "sarcoplasmic reticulum", "id": "GO:0016529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016529", "evidence": [ { "database": "UniProtKB", "id": "F1ME62", "url": "https://www.uniprot.org/uniprotkb/F1ME62" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1ME62", "url": "https://www.uniprot.org/uniprotkb/F1ME62" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1372, "end_pos": 1374, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1554, "end_pos": 1556, "annotation": "n_glycosylation_sequon" }, { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1766, "end_pos": 1768, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1801, "end_pos": 1803, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1820, "end_pos": 1822, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2369, "end_pos": 2371, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2816, "end_pos": 2818, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3499, "end_pos": 3501, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3706, "end_pos": 3708, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3835, "end_pos": 3837, "annotation": "n_glycosylation_sequon" }, { "start_pos": 594, "end_pos": 596, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1ME62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME62" }, { "id": "PS50188", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B30.2/SPRY", "eco_id": "ECO_0000259", "start_pos": 3799, "end_pos": 3984, "start_aa": "Asn", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1ME62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME62" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 3623, "end_pos": 3724, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 917 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 122, "end_pos": 124 }, { "start_pos": 1372, "end_pos": 1374 }, { "start_pos": 1554, "end_pos": 1556 }, { "start_pos": 166, "end_pos": 168 }, { "start_pos": 1766, "end_pos": 1768 }, { "start_pos": 1801, "end_pos": 1803 }, { "start_pos": 1820, "end_pos": 1822 }, { "start_pos": 2369, "end_pos": 2371 }, { "start_pos": 2816, "end_pos": 2818 }, { "start_pos": 3499, "end_pos": 3501 }, { "start_pos": 3706, "end_pos": 3708 }, { "start_pos": 3835, "end_pos": 3837 }, { "start_pos": 594, "end_pos": 596 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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}, { "field": "total_sites", "count": 1315 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 41 }, { "field": "total_sites", "count": 41 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 31 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MIH7-1", "uniprot_ac": "F1MIH7", "uniprot_id": "F1MIH7_BOVIN", "mass": { "chemical_mass": 79880.0, "monoisotopic_mass": 79880.0 }, "refseq": { "ac": "XP_005226359", "name": "rho-related BTB domain-containing protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226359" }, "gene_names": [ { "name": "RHOBTB1", "type": "recommended", "evidence": [ { "id": "F1MIH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ] }, { "name": "RHOBTB1", "type": "synonym", "evidence": [ { "id": "XP_005226359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226359" } ] } ], "protein_names": [ { "name": "Rho-related BTB domain-containing protein 1", "type": "recommended", "evidence": [ { "id": "F1MIH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIH7/entry#names_and_taxonomy" } ] }, { "name": "rho-related BTB domain-containing protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005226359", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226359" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RHOBTB1", "url": "https://www.uniprot.org/uniprotkb/F1MIH7", "locus": { "chromosome": "28", "start_pos": 16637420, "end_pos": 16711288, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019164", "url": "https://www.ensembl.org/id/ENSBTAG00000019164" } ] } } ], "crossref": [ { "id": "F1MIH7", "url": "https://alphafold.ebi.ac.uk/entry/F1MIH7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019164", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019164", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01873", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01873", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18355", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18355", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18358", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18358", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18530", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18530", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540513", "url": "https://www.ncbi.nlm.nih.gov/gene/540513", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YLDETQC", "url": "https://omabrowser.org/oma/group/YLDETQC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MIH7", "url": "https://www.orthodb.org/?gene=F1MIH7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24072", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24072", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24413", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24413", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9013422", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013422", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005226359", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226359", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQL7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N2U6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2U6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N2U6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2U6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIH7-1", "url": "https://www.uniprot.org/uniprotkb/F1MIH7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDADMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKTMWYQEIKHFCPRTPVVLVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGIPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSTGTNEAACLLDNPLCADVLFILQDQEQIFAHRIYLATSSSKFYDLFLMECEETPHWSEGACEREKQSRDSQEWAQSLDPDEEREEGTPRTPQADQWTPSSQNLSQQETLGLDAEDLVAETQTLLGWSKGFIGMHKEMQVNPVSKRLGPVTVVRMDASVQPGPFRTLLQFLYTGQLDEKEKDLVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFKLDDGAISAHKPLLICSCKWMAAMFGGSFVESANSEVYLPNINKMSMQAVLDYLYTKHLPPNLDLDPLELIALANRFCLPHLVALAEQHAVQELTKAAMSGVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDIALNKHHSRRKWCFWNSSPAVA", "length": 698, "header": "tr|F1MIH7-1|F1MIH7_BOVIN Isoform 1 of Rho-related BTB domain-containing protein 1 OS=Bos taurus OX=9913 GN=RHOBTB1 PE=3 SV=1 CANONICAL=F1MIH7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MQL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQL7/entry", "sequence": { "sequence": "MDADMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKTMWYQEIKHFCPRTPVVLVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGIPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSTGTNEAACLLDNPLCADVLFILQDQEQIFAHRIYLATSSSKFYDLFLMECEETPHWSEGACEREKQSRDSQEWAQSLDPDEEREEGTPRTPQADQWTPSSQNLSQQETLGLDAEDLVAETQTLLGWSKGFIGMHKEMQVNPVSKRLGPVTVVRMDASVQPGPFRTLLQFLYTGQLDEKEKDLVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFKLDDGAISAHKPLLICSCKWMAAMFGGSFVESANSEVYLPNINKMSMQAVLDYLYTKHLPPNLDLDPLELIALANRFCLPHLVALAEQHAVQELTKAAMSGVGIDGEVLSYLELAQGEIYYQGKLEALAKIVCPAGLVICREFLELVSRDVGFSLGLCSGH", "length": 652, "header": "tr|A0A3Q1MQL7-1|F1MIH7_BOVIN Computationally mapped isoform of Rho-related BTB domain-containing protein 1 OS=Bos taurus OX=9913 GN=RHOBTB1 PE=3 SV=1 CANONICAL=F1MIH7-1" }, "locus": { "chromosome": "28", "start_pos": 16676185, "end_pos": 16639269, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071425.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071425.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074320.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074320.2" } ] } }, { "isoform_ac": "A0A3Q1N2U6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2U6/entry", "sequence": { "sequence": "MDADMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSVSLRLWDTFGDHHKDRRFAYGRPIKRGDILPPEKGREVAKELGIPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSTGTNEAACLLDNPLCADVLFILQDQEQIFAHRIYLATSSSKFYDLFLMECEETPHWSEGACEREKQSRDSQEWAQSLDPDEEREEGTPRTPQADQWTPSSQNLSQQETLGLDAEDLVAETQTLLGWSKGFIGMHKEMQVNPVSKRLGPVTVVRMDASVQPGPFRTLLQFLYTGQLDEKEKDLVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFKLDDGAISAHKPLLICSCKWMAAMFGGSFVESANSEVYLPNINKMSMQAVLDYLYTKHLPPNLDLDPLELIALANRFCLPHLVALAEQHAVQELTKAAMSGVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDIALNKHHSRRKWCFWNSSPAVA", "length": 636, "header": "tr|A0A3Q1N2U6-1|F1MIH7_BOVIN Computationally mapped isoform of Rho-related BTB domain-containing protein 1 OS=Bos taurus OX=9913 GN=RHOBTB1 PE=3 SV=1 CANONICAL=F1MIH7-1" }, "locus": { "chromosome": "28", "start_pos": 16676185, "end_pos": 16637710, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082891.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082891.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063646.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063646.2" } ] } }, { "isoform_ac": "F1MIH7-1", "url": "https://www.uniprot.org/uniprotkb/F1MIH7/entry", "sequence": { "sequence": "MDADMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKTMWYQEIKHFCPRTPVVLVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGIPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSTGTNEAACLLDNPLCADVLFILQDQEQIFAHRIYLATSSSKFYDLFLMECEETPHWSEGACEREKQSRDSQEWAQSLDPDEEREEGTPRTPQADQWTPSSQNLSQQETLGLDAEDLVAETQTLLGWSKGFIGMHKEMQVNPVSKRLGPVTVVRMDASVQPGPFRTLLQFLYTGQLDEKEKDLVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFKLDDGAISAHKPLLICSCKWMAAMFGGSFVESANSEVYLPNINKMSMQAVLDYLYTKHLPPNLDLDPLELIALANRFCLPHLVALAEQHAVQELTKAAMSGVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDIALNKHHSRRKWCFWNSSPAVA", "length": 698, "header": "tr|F1MIH7-1|F1MIH7_BOVIN Isoform 1 of Rho-related BTB domain-containing protein 1 OS=Bos taurus OX=9913 GN=RHOBTB1 PE=3 SV=1 CANONICAL=F1MIH7-1" }, "locus": { "chromosome": "28", "start_pos": 16676185, "end_pos": 16637710, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025506.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025506.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025506.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025506.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9013422", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013422", "resource": "Reactome", "description": "RHOBTB1 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AL07-1", "protein_name": "Rho-related BTB domain-containing protein 1", "gene_name": "RHOBTB1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDTDMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKTMWYQEIKHFCPRTPVVLVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGIPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSMGTKEAACLLDNPLCADVLFVLQGQEQIFAHRIYLATSSSKFYDLFLMECEETPNWSEGACEREKPSLDFQAQELSLDLNEEREEGSPRTPQADQRTSPSQNVLQPEGPGLEAEGTVVETQSLSGWSKGFLGMHREMQVNPISKRVGPVTVVRMDASVQPGPFRTLLQFLYTGQLDEKEKDLMGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFKLDDGAISAHKPLLICSCKWMAAMFGGSFVESANSEVYLPNINKMSMQAVLDYLYTKQLSPNLDLDPLELIALANRFCLPHLVALAEQHAVQELTKAAMSGVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQAYFERHRWPPVWYLKEEDHYQRVKREREKEDIALNKHHSRRKWCFWNSSPAVA", "length": 698 }, "evidence": [ { "id": "F1MIH7", "url": "https://omabrowser.org/oma/group/F1MIH7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2N378-1", "protein_name": "Rho-related BTB domain-containing protein 1", "gene_name": "Rhobtb1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDTDMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSISLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKTMWYQEIKHFCPRTPVVLVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGIPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSAGTSDAACLLDNPLCADVLFVLQGQEHIFAHRIYLATSSSKFYDLFLMECEESPGWGGGAGEEMPCRDFQGRTQSIGPAEEGKKSSQRTLQAAGPGASSVQDLLESLALQTEASGSEAQALTGWSKGFVSMHREARVNPISKRVGPVTVVRLDSSMQSGPFRTLLRFLYTGQLDEKEKDLLGLAQMAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFTLDDGAISAHKPLLICSCEWMAAMFGGSFVESANSEVHLPSINKMSMQAVLEYLYTKQLSPNLDLDPLELIALANRFCLPHLVALVEQHAVQELTKAAMSGVGIDGEVLSYLELAQFHNANQLAAWCLHHICTNYNSVCSKFRKEIKSKSTDNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDLALKKHYSRRKWCFWHSSPAVA", "length": 696 }, "evidence": [ { "id": "F1MIH7", "url": "https://omabrowser.org/oma/group/F1MIH7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8M1RSW5-1", "protein_name": "Rho-related BTB domain-containing protein 1", "gene_name": "rhobtb1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDDVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKTMWYLEIKHFCPRTPVILVGCQLDLRYADLEAVNRARRPLSRPIKPGDILPPESGREVAKELGIPYYETSVFDQFGIKDIFDNAIRAALISRRHLQFWKSHLRRVQKPLLQAPFLPPKAPPPLIKIPECPAKNRDGPKQLLETPLCADVMFIVQEHVHLYAHRIYLSTSSSKFFDLFQMDFSDESQCLVVTERHGRDQLMRTLSLDTEEDVMVLPNLSPCSLRASKSDGTLKMLSFSGMHRRTRLSLASWSKAFYSIHKENVINPVTGTPALMTIVKMDHSIHHGPFSAVLRFLYTGELDEKEKDLMKIAQIAEILEVFDLRMMVENIMNNEGFMNQEITKAFHVRKANRIKECLAKNNFTDVVFRLDDGTINAHKPLLISSCDWMAALFGGSFMESANDEVSFPNTSRVCMQAVLEYLYTNQLSPMADLDPMELIALANRLCLPRLIALTEQYAVSELLKASKDGQDIDGEVLTYLELAQFHNANQLAAWCLHHICTHYNRICANYRKEIKSKSPENQEYFEKHRWPPVWYLKEEDHYQRVKKEREKEDVVLNKHHSRRRWCFWSTSPAVA", "length": 687 }, "evidence": [ { "id": "F1MIH7", "url": "https://omabrowser.org/oma/group/F1MIH7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZD37-1", "protein_name": "Rho-related BTB domain-containing protein 1", "gene_name": "Rhobtb1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDSDMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSISLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKTMWYQEIKHFCPRTPVVLVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGIPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSTGTSDAACLLDNPLCADVLFILHDQEHIFAHRIYLATSSSKFYDLFLMECEDSPGWSGGAGEEVPCRDFQGRTQSLGAAEEGQEGSQRTPQADPGASSGQDLLESLASQTDASVSEAHALTGWSKGFVSMHREVRVNPISKRVGPVTVVRLDSSMQSGPFRTLLRFLYSGQLDEKEKDLLGLAQMAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFTLDDGAISAHKPLLICSCEWMAAMFGGSFVESTNSEVHLPNINKMSMQAVLEYLYTKQLSPNLDLDPLELIALANRFCLTHLVALVEQHAVQELTKAAVSGVSIDGEVLSYLELAQFHNANQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDLALNKHHSRRKWCFWHPSPAVA", "length": 695 }, "evidence": [ { "id": "F1MIH7", "url": "https://omabrowser.org/oma/group/F1MIH7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O94844-1", "protein_name": "Rho-related BTB domain-containing protein 1", "gene_name": "RHOBTB1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDADMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKSMWYPEIKHFCPRTPVILVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGLPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKIPECPSMGTNEAACLLDNPLCADVLFILQDQEHIFAHRIYLATSSSKFYDLFLMECEESPNGSEGACEKEKQSRDFQGRILSVDPEEEREEGPPRIPQADQWKSSNKSLVEALGLEAEGAVPETQTLTGWSKGFIGMHREMQVNPISKRMGPMTVVRMDASVQPGPFRTLLQFLYTGQLDEKEKDLVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFKLDDGAISAHKPLLICSCEWMAAMFGGSFVESANSEVYLPNINKISMQAVLDYLYTKQLSPNLDLDPLELIALANRFCLPHLVALAEQHAVQELTKAATSGVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDIALNKHRSRRKWCFWNSSPAVA", "length": 696 }, "evidence": [ { "id": "F1MIH7", "url": "https://omabrowser.org/oma/group/F1MIH7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DAK3-1", "protein_name": "Rho-related BTB domain-containing protein 1", "gene_name": "Rhobtb1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDSDMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSISLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKTMWYQEIKHFCPRTPVVLVGCQLDLRYADLEAVNRARRPLARPIKRGDILPPEKGREVAKELGIPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSAGTSDAACLLDNPLCADVLFVLHDEEHIFAHRIYLATSSSKFYDLFLMECEESPCWGGGAGEEVPCRDFQGRTQSLGSAEEGKEGPQRTPQADPGASSGQDLPESLALQMEASGSEGHALSGWSKGFVSMHREVRVNPISKRVGPVTVVRLDPSMQSGPFRTLLRFLYSGQLDEKEKDLLGLAQMAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFTLDDGAISAHKPLLICSCEWMAAMFGGSFVESANREVHLPNINKMSMQAVLEYLYTKQLSPNLDLDPLELIALANRFCLTHLVALVEQHAVQELTKAAVSGVSIDGEVLSYLELAQFHNANQLAAWCLHHICTNYNSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDLALNKHHSRRKWCFWHSSPAVA", "length": 695 }, "evidence": [ { "id": "F1MIH7", "url": "https://omabrowser.org/oma/group/F1MIH7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" }, { "name": "cell projection", "id": "GO:0042995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" }, { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" }, { "name": "regulation of actin cytoskeleton organization", "id": "GO:0032956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032956", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" }, { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" }, { "name": "establishment or maintenance of cell polarity", "id": "GO:0007163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007163", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" }, { "name": "cortical cytoskeleton organization", "id": "GO:0030865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030865", "evidence": [ { "database": "UniProtKB", "id": "F1MIH7", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" }, { "start_pos": 692, "end_pos": 694, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MIH7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 698, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MIH7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MIH7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MIH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIH7" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 266, "end_pos": 429, "start_aa": "Ala", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 352, "end_pos": 354 }, { "start_pos": 37, "end_pos": 39 }, { "start_pos": 692, "end_pos": 694 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MHD9-1", "uniprot_ac": "F1MHD9", "uniprot_id": "F1MHD9_BOVIN", "mass": { "chemical_mass": 81286.0, "monoisotopic_mass": 81286.0 }, "refseq": {}, "gene_names": [ { "name": "LARP4", "type": "recommended", "evidence": [ { "id": "F1MHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHD9" } ] } ], "protein_names": [ { "name": "La ribonucleoprotein 4", "type": "synonym", "evidence": [ { "id": "F1MHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHD9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MHD9", "url": "https://www.uniprot.org/uniprotkb/F1MHD9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LARP4", "url": "https://www.uniprot.org/uniprotkb/F1MHD9", "locus": { "chromosome": "5", "start_pos": 29433902, "end_pos": 29503649, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017164", "url": "https://www.ensembl.org/id/ENSBTAG00000017164" } ] } } ], "crossref": [ { "id": "F1MHD9", "url": "https://alphafold.ebi.ac.uk/entry/F1MHD9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017164", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017164", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08035", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08035", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12707", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12707", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539286", "url": "https://www.ncbi.nlm.nih.gov/gene/539286", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006630", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006630", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MHD9", "url": "https://www.orthodb.org/?gene=F1MHD9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22792", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22792", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22792:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22792:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05383", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05383", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26088", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26088", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MUP2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUP2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUG1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUG1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUG1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7G2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7G2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7G2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7G2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEI9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1X2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1X2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1X2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1X2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHD9", "url": "https://www.uniprot.org/uniprotkb/F1MHD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHD9-1", "url": "https://www.uniprot.org/uniprotkb/F1MHD9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWGRRGRKQVTSKGTGLNPNAKVWQEIPPGNTDATPVAHGTESSWHETAATSGSLPEGNRELADDMCKEYEVMYSSCETTRNITGIEESTDGMILGPEDLNYQIYDVSGESNSAISTEELKECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEEIKKLTTDPDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPIEEVKALFKNENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAKNGYRLMDSSMYSQPIQTQAQYASPVFMQPVYNPHQQYSVYSIVPQSWSPNPAPYFETPLAPFPNGSFVNGFNSPGSYKTNAAAAAAAAAAAAAVNMGRPFQKNRVKTHFRSGGSEHSTEGSVSLGDGPLTRSGSRNFATERHNPAVTGHQEQSYLPKETPTLQMEQNGDYGRGRRTLFRGRRRREDERIPRPHPSTAEAKVPTPKFDLLASNFPPLPGSSSRTPGELVLESRMSDVVKGVCKEKDNEEFRVSCPVPAEDGQTDCTSAQQLSMSPSPPCTAELSALSTTQPEKDLVEDSTVQKDVPSQPTVPVSSPSTAKPSRTNTASPCNSNISAAVAVALQEPRKLSYAEVCQKPPKEPAPALAQPLRELRSNAVSPTKNEENGAPEKSFEKQHEKPEARASKDYSGFRGNAIPRGAAGKIREQRRQFGHRSIPQGVTRRNGKEQYVPPRSPK", "length": 735, "header": "tr|F1MHD9-1|F1MHD9_BOVIN Isoform 1 of La ribonucleoprotein 4 OS=Bos taurus OX=9913 GN=LARP4 PE=4 SV=4 CANONICAL=F1MHD9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MUP2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUP2/entry", "sequence": { "sequence": "MLLFVEQVTSKGTGLNPNAKVWQEIPPGNTDATPVAHGTESSWHETAATSGSLPEGNRELADDMCKEYEVMYSSCETTRNITGIEESTDGMILGPEDLNYQIYDVSGESNSAISTEELKECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEEIKKLTTDPDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPIEAFKYLREEVKTFQGKPIMARIKAINTFFAKNGYRLMDSSMYSQPIQTQAQYASPVFMQPVYNPHQQYSVYSIVPQSWSPNPAPYFETPLAPFPNGSFVNGFNSPGSYKTNAAAAAAAAAAAAAVNMGRPFQKNRVKTHFRSGGSEHSTEGSVSLGDGPLTRSGSRNFATERHNPAVTGHQEQSYLPKETPTLQMEQNGDYGRGRRTLFRGRRRREDERIPRPHPSTAEAKVPTPKFDLLASNFPPLPGSSSRTPGELVLESRMSDVVKGVCKEKDNEEFRVSCPVPAEDGQTDCTSAQQLSMSPSPPCTAELSALSTTQPEKDLVEDSTVQKDVPSQPTVPVSSPSTAKPSRTNTASPCNSNISAAVAVALQEPRKLSYAEVCQKPPKEPAPALAQPLRELRSNAVSPTKNEENGAPEKSFEKQHEKPEARASKDYSGFRGNAIPRGAAGKIREQRRQFGHRSIPQGVTRRNGKEQYVPPRSPK", "length": 696, "header": "tr|A0A3Q1MUP2-1|F1MHD9_BOVIN Computationally mapped isoform of La ribonucleoprotein 4 OS=Bos taurus OX=9913 GN=LARP4 PE=4 SV=1 CANONICAL=F1MHD9-1" }, "locus": { "chromosome": "5", "start_pos": 29503340, "end_pos": 29435969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072760.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072760.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074341.2", "url": "https://www.ensembl.org/id/ENSBTAP00000074341.2" } ] } }, { "isoform_ac": "A0AAA9SUG1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUG1/entry", "sequence": { "sequence": "MLLFVEQVTSKGTGLNPNAKVWQEIPPGNTDATPVAHGTESSWHETAATSGSLPEGNRELADDMCKEYEVMYSSCETTRNITGIEESTDGMILGPEDLNYQIYDVSGESNSAISTEELKECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEEIKKLTTDPDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPIEARIKAINTFFAKNGYRLMDSSMYSQPIQTQAQYASPVFMQPVYNPHQQYSVYSIVPQSWSPNPAPYFETPLAPFPNGSFVNGFNSPGSYKTNAAAAAAAAAAAAAVNMGRPFQKNRVKTHFRSGGSEHSTEGSVSLGDGPLTRSGSRNFATERHNPAVTGHQEQSYLPKETPTLQMEQNGDYGRGRRTLFRGRRRREDERIPRPHPSTAEAKVPTPKFDLLASNFPPLPGSSSRTPGELVLESRMSDVVKGVCKEKDNEEFRVSCPVPAEDGQTDCTSAQQLSMSPSPPCTAELSALSTTQPEKDLVEDSTVQKDVPSQPTVPVSSPSTAKPSRTNTASPCNSNISAAVAVALQEPRKLSYAEVCQKPPKEPAPALAQPLRELRSNAVSPTKNEENGAPEKSFEKQHEKPEARASKDYSGFRGNAIPRGAAGKIREQRRQFGHRSIPQGVTRRNGKEQYVPPRSPK", "length": 678, "header": "tr|A0AAA9SUG1-1|F1MHD9_BOVIN Computationally mapped isoform of La ribonucleoprotein 4 OS=Bos taurus OX=9913 GN=LARP4 PE=4 SV=1 CANONICAL=F1MHD9-1" }, "locus": { "chromosome": "5", "start_pos": 29503340, "end_pos": 29435969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094639.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094639.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090087.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090087.1" } ] } }, { "isoform_ac": "A0AAA9T7G2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7G2/entry", "sequence": { "sequence": "MLLFVEVTSKGTGLNPNAKVWQEIPPGNTDATPVAHGTESSWHETAATSGSLPEGNRELADDMCKEYEVMYSSCETTRNITGIEESTDGMILGPEDLNYQIYDVSGESNSAISTEELKECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEEIKKLTTDPDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPIEEVKALFKNENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAKNGYRLMDSSMYSQPIQTQAQYASPVFMQPVYNPHQQYSVYSIVPQSWSPNPAPYFETPLAPFPNGSFVNGFNSPGSYKTNAAAAAAAAAAAAAVNMGRPFQKNRVKTHFRSGGSEHSTEGSVSLGDGPLTRSGSRNFATERHNPAVTGHQEQSYLPKETPTLQMEQNGDYGRGRRTLFRGRRRREDERIPRPHPSTAEAKVPTPKFDLLASNFPPLPGSSSRTPGELVLESRMSDVVKGVCKEKDNEEFRVSCPVPAEDGQTDCTSAQQLSMSPSPPCTAELSALSTTQPEKDLVEDSTVQKDVPSQPTVPVSSPSTAKPSRTNTASPCNSNISAAVAVALQEPRKLSYAEVCQKPPKEPAPALAQPLRELRSNAVSPTKNEENGAPEKSFEKQHEKPEARASKDYSGFRGNAIPRGAAGKIREQRRQFGHRSIPQGVTRRNGKEQYVPPRSPK", "length": 732, "header": "tr|A0AAA9T7G2-1|F1MHD9_BOVIN Computationally mapped isoform of La ribonucleoprotein 4 OS=Bos taurus OX=9913 GN=LARP4 PE=4 SV=1 CANONICAL=F1MHD9-1" }, "locus": { "chromosome": "5", "start_pos": 29503340, "end_pos": 29435969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127225.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127225.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092542.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092542.1" } ] } }, { "isoform_ac": "A0AAA9TEI9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEI9/entry", "sequence": { "sequence": "MLLFVEQVTSKGTGLNPNAKVWQEIPPGNTDATPVAHGTESSWHETAATSGSLPEGNRELADDMCKEYEVMYSSCETTRNITGIEESTDGMILGPEDLNYQIYDVSGESNSAISTEELKECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEEIKKLTTDPDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPIEEVKALFKNENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAKNGYRLMDSSMYSQPIQTQAQYASPVFMQPVYNPHQQYSVYSIVPQSWSPNPAPYFETPLAPFPNGSFVNGFNSPGSYKTNAAAAAAAAAAAAAVNMGRPFQKNRVKTHFRSGGSEHSTEGSVSLGDGPLTRSGSRNFATERHNPAVTGHQEQSYLPKETPTLQMEQNGDYGRGRRTLFRGRRRREDERIPDNEEFRVSCPVPAEDGQTDCTSAQQLSMSPSPPCTAELSALSTTQPEKDLVEDSTVQKDVPSQPTVPVSSPSTAKPSRTNTASPCNSNISAAVAVALQEPRKLSYAEVCQKPPKEPAPALAQPLRELRSNAVSPTKNEENGAPEKSFEKQHEKPEARASKDYSGFRGNAIPRGAAGKIREQRRQFGHRSIPQGVTRRNGKEQYVPPRSPK", "length": 679, "header": "tr|A0AAA9TEI9-1|F1MHD9_BOVIN Computationally mapped isoform of La ribonucleoprotein 4 OS=Bos taurus OX=9913 GN=LARP4 PE=4 SV=1 CANONICAL=F1MHD9-1" }, "locus": { "chromosome": "5", "start_pos": 29503340, "end_pos": 29435969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121993.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121993.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097025.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097025.1" } ] } }, { "isoform_ac": "A0AAA9U1X2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1X2/entry", "sequence": { "sequence": "MLGKIEGKRRRGRQRMRWLDGITDSEDMSLRKFWEIVKDREDWSAAVRGVTESDTTERLNNIRENLSKDLYLISQMDSDQFVPIWTVANMEEIKKLTTDPDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPIEEVKALFKNENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAKNGYRLMDSSMYSQPIQTQAQYASPVFMQPVYNPHQQYSVYSIVPQSWSPNPAPYFETPLAPFPNGSFVNGFNSPGSYKTNAAAAAAAAAAAAAVNMGRPFQKNRVKTHFRSGGSEHSTEGSVSLGDGPLTRSGSRNFATERHNPAVTGHQEQSYLPKETPTLQMEQNGDYGRGRRTLFRGRRRREDERIPRPHPSTAEAKVPTPKFDLLASNFPPLPGSSSRTPGELVLESRMSDVVKGVCKEKDNEEFRVSCPVPAEDGQTDCTSAQQLSMSPSPPCTAELSALSTTQPEKDLVEDSTVQKDVPSQPTVPVSSPSTAKPSRTNTASPCNSNISAAVAVALQEPRKLSYAEVCQKPPKEPAPALAQPLRELRSNAVSPTKNEENGAPEKSFEKQHEKPEARASKDYSGFRGNAIPRGAAGKIREQRRQFGHRSIPQGVTRRNGKEQYVPPRSPK", "length": 664, "header": "tr|A0AAA9U1X2-1|F1MHD9_BOVIN Computationally mapped isoform of La ribonucleoprotein 4 OS=Bos taurus OX=9913 GN=LARP4 PE=4 SV=1 CANONICAL=F1MHD9-1" }, "locus": { "chromosome": "5", "start_pos": 29472773, "end_pos": 29435969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093746.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093746.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103898.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103898.1" } ] } }, { "isoform_ac": "F1MHD9-1", "url": "https://www.uniprot.org/uniprotkb/F1MHD9/entry", "sequence": { "sequence": "MWGRRGRKQVTSKGTGLNPNAKVWQEIPPGNTDATPVAHGTESSWHETAATSGSLPEGNRELADDMCKEYEVMYSSCETTRNITGIEESTDGMILGPEDLNYQIYDVSGESNSAISTEELKECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEEIKKLTTDPDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPIEEVKALFKNENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAKNGYRLMDSSMYSQPIQTQAQYASPVFMQPVYNPHQQYSVYSIVPQSWSPNPAPYFETPLAPFPNGSFVNGFNSPGSYKTNAAAAAAAAAAAAAVNMGRPFQKNRVKTHFRSGGSEHSTEGSVSLGDGPLTRSGSRNFATERHNPAVTGHQEQSYLPKETPTLQMEQNGDYGRGRRTLFRGRRRREDERIPRPHPSTAEAKVPTPKFDLLASNFPPLPGSSSRTPGELVLESRMSDVVKGVCKEKDNEEFRVSCPVPAEDGQTDCTSAQQLSMSPSPPCTAELSALSTTQPEKDLVEDSTVQKDVPSQPTVPVSSPSTAKPSRTNTASPCNSNISAAVAVALQEPRKLSYAEVCQKPPKEPAPALAQPLRELRSNAVSPTKNEENGAPEKSFEKQHEKPEARASKDYSGFRGNAIPRGAAGKIREQRRQFGHRSIPQGVTRRNGKEQYVPPRSPK", "length": 735, "header": "tr|F1MHD9-1|F1MHD9_BOVIN Isoform 1 of La ribonucleoprotein 4 OS=Bos taurus OX=9913 GN=LARP4 PE=4 SV=4 CANONICAL=F1MHD9-1" }, "locus": { "chromosome": "5", "start_pos": 29502906, "end_pos": 29435969, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022821.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022821.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022821.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022821.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MHD9", "url": "https://www.uniprot.org/uniprotkb/F1MHD9" } ], "pmid": "" }, { "name": "cytoplasmic stress granule", "id": "GO:0010494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010494", "evidence": [ { "database": "UniProtKB", "id": "F1MHD9", "url": "https://www.uniprot.org/uniprotkb/F1MHD9" } ], "pmid": "" }, { "name": "cytosolic small ribosomal subunit", "id": "GO:0022627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022627", "evidence": [ { "database": "UniProtKB", "id": "F1MHD9", "url": "https://www.uniprot.org/uniprotkb/F1MHD9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of translation", "id": "GO:0045727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045727", "evidence": [ { "database": "UniProtKB", "id": "F1MHD9", "url": "https://www.uniprot.org/uniprotkb/F1MHD9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "mRNA 3'-UTR binding", "id": "GO:0003730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003730", "evidence": [ { "database": "UniProtKB", "id": "F1MHD9", "url": "https://www.uniprot.org/uniprotkb/F1MHD9" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1MHD9", "url": "https://www.uniprot.org/uniprotkb/F1MHD9" } ], "pmid": "" }, { "name": "poly(A) binding", "id": "GO:0008143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008143", "evidence": [ { "database": "UniProtKB", "id": "F1MHD9", "url": "https://www.uniprot.org/uniprotkb/F1MHD9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 613, "end_pos": 615, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MHD9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 735, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MHD9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MHD9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHD9" }, { "id": "PS50961", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50961" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HTH La-type RNA-binding", "eco_id": "ECO_0000259", "start_pos": 114, "end_pos": 203, "start_aa": "Ala", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 136, "end_pos": 138 }, { "start_pos": 345, "end_pos": 347 }, { "start_pos": 613, "end_pos": 615 }, { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MFC9-1", "uniprot_ac": "F1MFC9", "uniprot_id": "F1MFC9_BOVIN", "mass": { "chemical_mass": 63971.0, "monoisotopic_mass": 63971.0 }, "refseq": { "ac": "XP_005217838", "name": "tectonic-1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217838" }, "gene_names": [ { "name": "TCTN1", "type": "recommended", "evidence": [ { "id": "F1MFC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFC9" } ] }, { "name": "TCTN1", "type": "synonym", "evidence": [ { "id": "XP_005217838", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217838" } ] } ], "protein_names": [ { "name": "Tectonic family member 1", "type": "synonym", "evidence": [ { "id": "F1MFC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFC9/entry#names_and_taxonomy" } ] }, { "name": "tectonic-1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005217838", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217838" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFC9", "url": "https://www.uniprot.org/uniprotkb/F1MFC9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TCTN1", "url": "https://www.uniprot.org/uniprotkb/F1MFC9", "locus": { "chromosome": "17", "start_pos": 54505170, "end_pos": 54477705, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009208", "url": "https://www.ensembl.org/id/ENSBTAG00000009208" } ] } } ], "crossref": [ { "id": "F1MFC9", "url": "https://alphafold.ebi.ac.uk/entry/F1MFC9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009208", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009208", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510513", "url": "https://www.ncbi.nlm.nih.gov/gene/510513", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040354", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040354", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057724", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057724", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "AGDVKIC", "url": "https://omabrowser.org/oma/group/AGDVKIC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MVR4", "url": "https://www.orthodb.org/?gene=A0A3Q1MVR4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MFC9", "url": "https://www.orthodb.org/?gene=F1MFC9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N2E4", "url": "https://www.orthodb.org/?gene=G3N2E4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14611", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14611", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14611:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14611:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07773", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07773", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25752", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25752", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005217838", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217838", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVR4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVR4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RST6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RST6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RST6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RST6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPV6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TPV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPV6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFC9", "url": "https://www.uniprot.org/uniprotkb/F1MFC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFC9-1", "url": "https://www.uniprot.org/uniprotkb/F1MFC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2E4", "url": "https://www.uniprot.org/uniprotkb/G3N2E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N2E4-1", "url": "https://www.uniprot.org/uniprotkb/G3N2E4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPRAVPRLLLVLLDCWASVSAQAGTTPVVTTEGLNSTKPVPTTLRSVISSKPPEIPRASRPFSGPRPAPVTDVAALCVCDLSPAQCDVNCCCDPDCSSVDFSVFSACSIPVVTGDSHFCSQKAAVYSLNFTADPPQRVFKLVDQINPSIFCVHITNYKPALSFINPEVTDESSFDKLMKAPDGFSLNAESDVSTRLDAPQTAKYEYGVPLQTSDSFLRFPSPLTSSLCTDNNPAAFLVNQAVKCTRRINLEHCEEMETLSMAYYSSPKILRVPGSGIEVPIMVQSIVIRSLNKTLTRLEDTEILRVSKQGVVEAGHIKICTNVVLEVMYSLTYTDTGEVIKADLFLLLGAVSSAMVPLQQKFEIYFIQQNAKPVPLSGNPGYVVGLPLVAGFQPQKGSGIIQTTNRYGQLTLLRSTTEQDCLAAEGIRAPVLFGYNMQSGCKLRLTKALTCRLVAQKMKSLLKGQGFPDYVAPFGNSQAQDVLDWVPVYFITQTSHVKDSCQLPVALTVEVKWTKYGSLLNPQAKIVNVTARLISSSFPETNSGNERTILISTAVTFVDVSAPAEAGFRARPTINARLPFNFFFPFV", "length": 588, "header": "tr|F1MFC9-1|F1MFC9_BOVIN Isoform 1 of Tectonic family member 1 OS=Bos taurus OX=9913 GN=TCTN1 PE=3 SV=3 CANONICAL=F1MFC9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MVR4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVR4/entry", "sequence": { "sequence": "MGPRAVPRLLLVLLDCWASVSAQAGTTPVVTTEGLNSTKPVPTTLRSVISSKPPEIPRASRPFSGPRPAPVTDVAALCVCDLSPAQCDVNCCCDPDCSSVDFSVFSACSIPVVTGDSHFCSQKAAVYSLNFTADPPQRVFKLVDQINPSIFCVHITNYKPALSFINPEVTDESSFDKLMKAPDGFSLNAESDVSTRLDAPQTAKYEYGVPLQTSDSFLRFPSPLTSSLCTDNNPAAFLVNQAVKCTRRINLEHCEEMETLSMAYYSSPKILRVPGSGIEVPIMVQSIVIRSLNKTLTRLEDTEILRVSKQGVVEAGHIKICTNVVLEVMYSLTYTDTGEVIKADLFLLLGAVSSAMVPLQQKFEIYFIQDSCQLPVALTVEVKWTKYGSLLNPQAKIVNVTARLISSSFPETNSGNERTILISTAVTFVDVSAPAEAGFRARPTINARLPFNFFFPFV", "length": 458, "header": "tr|A0A3Q1MVR4-1|F1MFC9_BOVIN Computationally mapped isoform of Tectonic family member 1 OS=Bos taurus OX=9913 GN=TCTN1 PE=3 SV=2 CANONICAL=F1MFC9-1" }, "locus": { "chromosome": "17", "start_pos": 54504176, "end_pos": 54477770, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077603.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077603.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059226.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059226.2" } ] } }, { "isoform_ac": "A0AAA9RST6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RST6/entry", "sequence": { "sequence": "MGPRAVPRLLLVLLDCWASVSAQAGTTPVVTTEGLNSTKPVPTTLRSVISSKPPEIPRASRPFSGPRPAPVTDVAALCVCDLSPAQCDVNCCCDPDCSSVDFSVFSACSIPVVTGDSHFCSQKAAVYSLNFTADPPQRVFKLVDQINPSIFCVHITNYKPALSFINPEVTDESSFDKLMKAPDGFSLNAESDVSTRLDAPQTAKYEYGVPLQTSDSFLRFPSPLTSSLCTDNNPAAFLVNQAVKCTRRINLEHCEEMETLSMAYYSSPKILRVPGSGIEDSCQLPVALTVEVKWTKYGSLLNPQAKIVNVTARLISSSFPETNSGNERTILISTAVTFVDVSAPAEAGFRARPTINARLPFNFFFPFV", "length": 368, "header": "tr|A0AAA9RST6-1|F1MFC9_BOVIN Computationally mapped isoform of Tectonic family member 1 OS=Bos taurus OX=9913 GN=TCTN1 PE=3 SV=1 CANONICAL=F1MFC9-1" }, "locus": { "chromosome": "17", "start_pos": 54504176, "end_pos": 54477770, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098673.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098673.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075759.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075759.1" } ] } }, { "isoform_ac": "A0AAA9TPV6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPV6/entry", "sequence": { "sequence": "MGPRAVPRLLLVLLDCWASVSAQAGTTPVVTTEGLNSTKPVPTTLRSVISSKPPEIPRASRPFSGPRPAPVTDVAALCVCDLSPAQCDVNCCCDPDCSSVDFSVFSACSIPVVTGDSHFCSQKAAVYSLNFTADPPQRVFKLVDQINPSIFCVHITNYKPALSFINPEVTDESSFDKLMKAPDGFSLNAESDVSTRLDAPQTAKYEYGVPLQTSDSFLRFPSPLTSSLCTDNNPAAFLVNQAVKCTRRINLEHCEEMETLSMAYYSSPKILRVPGSGIEVPIMVQSIVIRSLNKTLTRLEDTEILRVSKQGVVEAGHIKICTNVVLEVMYSLTYTDTGEVIKADLFLLLGAVSSAMVPLQQKFEIYFIQTTNRYGQLTLLRSTTEQDCLAAEGIRAPVLFGYNMQSGCKLRLTKALTCRLVAQKMKSLLKGQGFPDYVAPFGNSQAQDVLDWVPVYFITQTSHVKDSCQLPVALTVEVKWTKYGSLLNPQAKIVNVTARLISSSFPETNSGNERTILISTAVTFVDVSAPAEAGFRARPTINARLPFNFFFPFV", "length": 554, "header": "tr|A0AAA9TPV6-1|F1MFC9_BOVIN Computationally mapped isoform of Tectonic family member 1 OS=Bos taurus OX=9913 GN=TCTN1 PE=3 SV=2 CANONICAL=F1MFC9-1" }, "locus": { "chromosome": "17", "start_pos": 54504176, "end_pos": 54477770, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121273.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121273.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099057.2", "url": "https://www.ensembl.org/id/ENSBTAP00000099057.2" } ] } }, { "isoform_ac": "F1MFC9-1", "url": "https://www.uniprot.org/uniprotkb/F1MFC9/entry", "sequence": { "sequence": "MGPRAVPRLLLVLLDCWASVSAQAGTTPVVTTEGLNSTKPVPTTLRSVISSKPPEIPRASRPFSGPRPAPVTDVAALCVCDLSPAQCDVNCCCDPDCSSVDFSVFSACSIPVVTGDSHFCSQKAAVYSLNFTADPPQRVFKLVDQINPSIFCVHITNYKPALSFINPEVTDESSFDKLMKAPDGFSLNAESDVSTRLDAPQTAKYEYGVPLQTSDSFLRFPSPLTSSLCTDNNPAAFLVNQAVKCTRRINLEHCEEMETLSMAYYSSPKILRVPGSGIEVPIMVQSIVIRSLNKTLTRLEDTEILRVSKQGVVEAGHIKICTNVVLEVMYSLTYTDTGEVIKADLFLLLGAVSSAMVPLQQKFEIYFIQQNAKPVPLSGNPGYVVGLPLVAGFQPQKGSGIIQTTNRYGQLTLLRSTTEQDCLAAEGIRAPVLFGYNMQSGCKLRLTKALTCRLVAQKMKSLLKGQGFPDYVAPFGNSQAQDVLDWVPVYFITQTSHVKDSCQLPVALTVEVKWTKYGSLLNPQAKIVNVTARLISSSFPETNSGNERTILISTAVTFVDVSAPAEAGFRARPTINARLPFNFFFPFV", "length": 588, "header": "tr|F1MFC9-1|F1MFC9_BOVIN Isoform 1 of Tectonic family member 1 OS=Bos taurus OX=9913 GN=TCTN1 PE=3 SV=3 CANONICAL=F1MFC9-1" }, "locus": { "chromosome": "17", "start_pos": 54504176, "end_pos": 54477770, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012137.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012137.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012137.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012137.5" } ] } }, { "isoform_ac": "G3N2E4-1", "url": "https://www.uniprot.org/uniprotkb/G3N2E4/entry", "sequence": { "sequence": "MGPRAVPRLLLVLLDCWASVSAQAGTTPVVTTEGLNSTKPVPTTLRSVISSKPPEIPRASRPFSGPRPAPVTDVAALCVCDLSPAQCDVNCCCDPDCSSVDFSVFSACSIPVVTGDSHFCSQKAAVYSLNFTADPPQRVFKLVDQINPSIFCVHITNYKPALSFINPEVTDESSFDKLMKAPDGFSLNAESDVSTRLDAPQTAKYEYGVPLQTSDSFLRFPSPLTSSLCTDNNPAAFLVNQAVKCTRRINLEHCEEMETLSMAYYSSPKILRVPGSGIEVPIMVQSIVIRSLNKTLTRLEDTEILRVSKQGVVEAGHIKICTNVVLEVMYSLTYTDTGEVIKADLFLLLGAVSSAMVPLQQKFEIYFIQQNAKPVPLSGNPGYVVGLPLVAGFQPQKGKALTCRLVAQKMKSLLKGQGFPDYVAPFGNSQAQDVLDWVPVYFITQTSHVKDSCQLPVALTVEVKWTKYGSLLNPQAKIVNVTARLISSSFPETNSGNERTILISTAVTFVDVSAPAEAGFRARPTINARLPFNFFFPFV", "length": 539, "header": "tr|G3N2E4-1|F1MFC9_BOVIN Computationally mapped isoform of Tectonic family member 1 OS=Bos taurus OX=9913 GN=TCTN1 PE=3 SV=3 CANONICAL=F1MFC9-1" }, "locus": { "chromosome": "17", "start_pos": 54504176, "end_pos": 54477770, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065505.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065505.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056056.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056056.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A5X0-1", "protein_name": "Tectonic family member 1", "gene_name": "TCTN1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAALRLGLLLFLSPLRAAEPSTELPSSPEASSKTRATAWKRGRSGPAPLTDVAKLCVCDLLVAQCDVNCCCDPDCSAEDFSLFTTCSVPIVTGDSRLCSQKAAIYSLDTEANPPERVFKLVDHINPSVFCIHATNYEQALSFSSPETPTAENFDQLLKKYGGATFSAEPNSWSMNSDASDPSDANKSYRYEYGVPIQTVDAFLRLPSPVVSSWCSDANPAGFLVHQATKCIRSISVENCGNIQAVSMLFYINSSILAVPKSSQMVNITVQSVVVQSLNGMRTLLNSRDVLRHPMILDELCINIVLGVSYHITYTDTGEIIEAAASFVLGAVNKEALSVQQSFEISFTQVNTNPVPFSGNPGYVVGLAVRAGFKPQGYPFPIVILLSVLFLDQLHSDFLSWTPYIFHLFFTESKCVLFGYILEVTNVSVLTAISWNCSARITAAMNCQPLAQVLLDLLMGQSFPEYVAPFGNSQAQDVLDWVPITHLRTSEQSSCQIPVALEIEVKWTKYGSLVNPQARIVNVTATTTTTTLKQLPLGRERTIPITSSVVFTDISSPAEPGYKAWPTINAKLPHDFFFPFV", "length": 581 }, "evidence": [ { "id": "F1MFC9", "url": "https://omabrowser.org/oma/group/F1MFC9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0M228-1", "protein_name": "Tectonic family member 1", "gene_name": "Tctn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGSRCLPPLLLVLLNCCTSSSTQVVATPAAATPVVTNEDLNFTEATPVVTNEDLNFTEATPVVTNEDLNFTEATPVVTNEDLNFTEATPATLRPSWSPRTPGTPRPPELSGPRPTPVTDVAALCVCDLLPAQCDINCCCDPDCSPGDFSVFSACSIPVVTGDRQFCSQKAAFYSMNLTADPPHRDFKLIDQINPSIFCIHISNYKPALSFANPEVPDENNFDRLMGASGGFTLSAESGVPSTATSDDPQPTKYEYGALLQTAGESSGSFLKLPSPLTSSLCADENPAAFLVNQAFECSRRVAIEECERMEALSMAHYSSPAILRVPNSTTQVSIKIQSIMYRSLNHTLTQLEGRGILRPSLVSTGQDRLCSNVVLQVKYSLLYTASGQIQEAGLSLVLGTLISTVSLLQQKFEIHFIQHGTKPVPLSGNPGYRVGLPLAAGFQPQKGSGIIQTTNRQGQLTILRSTGKQDCLASHGQRAPVLFGYNVQSGCQLRLTGTIPCGLLAQKMQDLLRGQAFPDYVAAFGNSRAQDVQDWVPVHFVTHSSNTKGSCQLPVALGIEVKWTKYGSLLNPQARIVNVTAQLISIPEPLPGPERTMVISTAVTFVDVSAPAEAGFRAPPTINARLPFSFFFPFV", "length": 635 }, "evidence": [ { "id": "F1MFC9", "url": "https://omabrowser.org/oma/group/F1MFC9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q2MV58-1", "protein_name": "Tectonic-1", "gene_name": "TCTN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRPRGLPPLLVVLLGCWASVSAQTDATPAVTTEGLNSTEAALATFGTFPSTRPPGTPRAPGPSSGPRPTPVTDVAVLCVCDLSPAQCDINCCCDPDCSSVDFSVFSACSVPVVTGDSQFCSQKAVIYSLNFTANPPQRVFELVDQINPSIFCIHITNYKPALSFINPEVPDENNFDTLMKTSDGFTLNAESYVSFTTKLDIPTAAKYEYGVPLQTSDSFLRFPSSLTSSLCTDNNPAAFLVNQAVKCTRKINLEQCEEIEALSMAFYSSPEILRVPDSRKKVPITVQSIVIQSLNKTLTRREDTDVLQPTLVNAGHFSLCVNVVLEVKYSLTYTDAGEVTKADLSFVLGTVSSVVVPLQQKFEIHFLQENTQPVPLSGNPGYVVGLPLAAGFQPHKGSGIIQTTNRYGQLTILHSTTEQDCLALEGVRTPVLFGYTMQSGCKLRLTGALPCQLVAQKVKSLLWGQGFPDYVAPFGNSQAQDMLDWVPIHFITQSFNRKDSCQLPGALVIEVKWTKYGSLLNPQAKIVNVTANLISSSFPEANSGNERTILISTAVTFVDVSAPAEAGFRAPPAINARLPFNFFFPFV", "length": 587 }, "evidence": [ { "id": "F1MFC9", "url": "https://omabrowser.org/oma/group/F1MFC9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BZ64-1", "protein_name": "Tectonic-1", "gene_name": "Tctn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSRGLPPLLLVLLNCYTSSSTQVIAIPAAATPAVTKEDLNSTKATPTTLQPSLSPRTPGTPRAPERSGPRPTPVTDVAALCVCDLLPAQCDVNCCCDPDCSPADFSIFSACSVPVVTGDRQFCSQKAAFYSMNLTADPPHRDFKLIDQINPSVFCIHISNYKPALSFANPEVPDENNFDRLMQTSGGFTLSAESAVPSTAASDGPQPTKYEYGAPLQTAGASSGSFLKLPSPLTSSLCADQNPAAFLVSQAFECSRRVDIEQCEGMEALSMAHYSSPAILRVPNSMTQVSIKIQSVMYRSLNHTLTQLEGHGVLRPSLVSTGQDRLCSNVVLQVKYSLLYTATGQIHEAGLSLVLGTLSSAVSLLQQKFEIHFIQHGTKPVPLSGNPGYRVGLPLAAGFQPQKGSGIIQTTNRQGQFTILRSTSQQDCLASEGLRTPVLFGYNVQSGCQLRLTGTIPCGLLAQKVQDLLRGQAFPDYVAAFGNSRAQDVQDWVPVHFVTYSSNMKGSCQLPVALAIEVKWTKYGSLLNPQARIVNVTAQLVSVPEPLPGPERTVVISTAVTFVDVSAPAEAGFRAPPTINARLPFSFFFPFV", "length": 593 }, "evidence": [ { "id": "F1MFC9", "url": "https://omabrowser.org/oma/group/F1MFC9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell projection organization", "id": "GO:0030030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "database": "UniProtKB", "id": "F1MFC9", "url": "https://www.uniprot.org/uniprotkb/F1MFC9" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "F1MFC9", "url": "https://www.uniprot.org/uniprotkb/F1MFC9" } ], "pmid": "" }, { "name": "protein localization to ciliary transition zone", "id": "GO:1904491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904491", "evidence": [ { "database": "UniProtKB", "id": "F1MFC9", "url": "https://www.uniprot.org/uniprotkb/F1MFC9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1MFC9", "url": "https://www.uniprot.org/uniprotkb/F1MFC9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MFC9", "url": "https://www.uniprot.org/uniprotkb/F1MFC9" } ], "pmid": "" }, { "name": "MKS complex", "id": "GO:0036038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036038", "evidence": [ { "database": "UniProtKB", "id": "F1MFC9", "url": "https://www.uniprot.org/uniprotkb/F1MFC9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 293, "end_pos": 295, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" }, { "start_pos": 529, "end_pos": 531, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MFC9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 588, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MFC9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MFC9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFC9" }, { "id": "PF07773", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07773" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tectonic-1-3", "eco_id": "ECO_0000259", "start_pos": 203, "end_pos": 369, "start_aa": "Ala", "end_aa": "Gln", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MFC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFC9" }, { "id": "PF25752", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25752" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tectonic-1-3 N-terminal", "eco_id": "ECO_0000259", "start_pos": 71, "end_pos": 174, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 }, { "start_pos": 293, "end_pos": 295 }, { "start_pos": 36, "end_pos": 38 }, { "start_pos": 529, "end_pos": 531 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MHB3-1", "uniprot_ac": "F1MHB3", "uniprot_id": "F1MHB3_BOVIN", "mass": { "chemical_mass": 174928.0, "monoisotopic_mass": 174928.0 }, "refseq": { "ac": "XP_024840316", "name": "SET-binding protein isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840316" }, "gene_names": [ { "name": "SETBP1", "type": "recommended", "evidence": [ { "id": "F1MHB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHB3" } ] }, { "name": "SETBP1", "type": "synonym", "evidence": [ { "id": "XP_024840316", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840316" } ] } ], "protein_names": [ { "name": "SET binding protein 1", "type": "synonym", "evidence": [ { "id": "F1MHB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHB3/entry#names_and_taxonomy" } ] }, { "name": "SET-binding protein isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024840316", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840316" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MHB3", "url": "https://www.uniprot.org/uniprotkb/F1MHB3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SETBP1", "url": "https://www.uniprot.org/uniprotkb/F1MHB3", "locus": { "chromosome": "24", "start_pos": 44682326, "end_pos": 44277350, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018088", "url": "https://www.ensembl.org/id/ENSBTAG00000018088" } ] } } ], "crossref": [ { "id": "ENSBTAG00000018088", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018088", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "617265", "url": "https://www.ncbi.nlm.nih.gov/gene/617265", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017956", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017956", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617265", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617265", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MXX5", "url": "https://www.orthodb.org/?gene=A0A3Q1MXX5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MHB3", "url": "https://www.orthodb.org/?gene=F1MHB3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46147", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46147", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46147:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46147:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_024840316", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840316", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXX5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MXX5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWZ4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9B5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9B5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHB3", "url": "https://www.uniprot.org/uniprotkb/F1MHB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHB3-1", "url": "https://www.uniprot.org/uniprotkb/F1MHB3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESREVLSGSRQRVSESEFLPVSSAKPSTTPSCTGEPLLSAPETGKGIPAGGERMEPEEEDELGSGRDVDSNSNADSEKWVAGDGLEEQEFSIKEANFTEGSLKLKIQTTKRAKKPPKNLENYICPPEIKITIKQSDQKVSRAGKNSKATKEEDRSHSKKKLLTASDLAASDLKGFQPQAYERPQKHSALHYDPGLPQDFTSDTLKPKHQQKSSSQNHMDWSTNSDNGPATQNCFISPESGRETASTSKIPALEPMASFAKAQGKKGSAGSTWNQLPNSNKDLLLGGVVPSPSNHSSPAPPSSSAECSGIQPLVDQDGGSTKEPLEPPTISSKKKSSKKDVISQTIPNSDLDWVKNAQKAFDSTEGKREGYSADSAQEASPARQNVSSVSNPENDSSHVRITIPIKAPCLDPSSHKRKKRQSIKAVVEKIMPEKALTSGITMSSEVVNRIFSNPEGNKKDPRVPKLGKMMENESPSAGLETGVNAEKVVPGGVPKQRKPPMVMTPPTCTDHSARKLPEIQHPKFAAKRRWTCSKPKPTSLLREAVMATSDKLMVEPPSAYPITPSSPLYTNTDSLTVITPVKKKRGRPKKQPLLTVETIHEGTSTSPVSPISREFPGTKKRKRRRSLAKLAQLVPGEDKPMSEMKFHKKVGKLGVLDKKTIKTINKMKTLKRKNILNQILSCSSSIALKAKAPPETSPGAAAIESKLGKQINVSKRGTIYIGKKRGRKPRAELPPPSEEPKTAIKHPRPVSSQPDVPAVPSNLQSLVASSPAAMHPLSTQLGGSNGNLSPASTETNFSELKTMPNLQPISALPTKTQKGIHSGTWKLSPPRLMANSPSHLCEIGSLKEITLSPVSESHSEETIPSDSGIGTDNNSTSDQAEKSSESRRRYSFDFCSLDNPEAIPSDTSTKNRHGHRQKHLIVDNFLAHESLKKPKHKRKRKSLQNRDDLQFLADLEELITKFQVFRISHRSYTFYHENPYPSIFRINFDHYYPVPYIQYDPLLYLRRTSDLKSKKKRGRPAKTNDTMTKVPFLQGFSYPIPSGSYYAPYGMPYTSMPMMNLGYYSQYPAPVYLSHTLGAASPFMRPTVPPPQFHTSSHVKMSGTAKHKAKHGVHLQGPVGMGLGDRQPSLNPPKVGSASLSSGRLHKRKHKHKHKHKEDRLLGTHDNLSGLFAGKATGFSSHILSERLSSADKELSLVSEKNKHKEKQKHQHSEASHKASKNNFEVDTLSTLSLSDAQHWTQAKDKGDLSSEPADSCAKRYSGNGGDGGGARPESLDVFSEMNPPNDKWDSDVSASKRRSYEGFGTYREKDIQAFKMNRKERSPYDSSVSPGIPSPHLKVDQTATHGKNESSASTVMTRKKPATVDSVAIPPAPVLSLLAASAATSDAASSSLKKRFKRREIEAIQCEVRKMCNYTKILSTKKNLDHVNKILKAKRLQRQSKTGNNFVKKRRGRPRKQPTQFDEDSRDQMPVLEKCIDLPSKRGQKPSLSPLVLEPAASQDTIMATIEAVIHMAREAPPLPPPPPPPLPPPPPPPPPPPPPLPKTPRGGGKRKHKPQPPAQPPQQAPPPQPLPPEEEVKAKRQRKSRGSESDVLP", "length": 1595, "header": "tr|F1MHB3-1|F1MHB3_BOVIN Isoform 1 of SET binding protein 1 OS=Bos taurus OX=9913 GN=SETBP1 PE=4 SV=3 CANONICAL=F1MHB3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MXX5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXX5/entry", "sequence": { "sequence": "MESREVLSGSRQRVSESEFLPVSSAKPSTTPSCTGEPLLSAPETGKGIPAGGERMEPEEEDELGSGRDVDSNSNADSEKWVAGDGLEEQEFSIKEANFTEGSLKLKIQTTKRAKKPPKNLENYICPPEIKITIKQSDQKVSRAGKNSKATKEEDRSHSKKKLLTASDLAASDLKGFQPQAYERPQKHSALHYDPGLPQDFTSDTLKPKHQQKSSSQNHMDWSTNSDNGPATQNCFISPESGRETASTSKIPALEPMASFAKAQGKKGSAGSTWNQLPNSNKDLLLGGVVPSPSNHSSPAPPSSSAECSGIQPLVDQDGGSTKEPLEPPTISSKKKSSKKDVISQTIPNSDLDWVKNAQKAFDSTEGKREGYSADSAQEASPARQNVSSVSNPENDSSHVRITIPIKAPCLDPSSHKRKKRQSIKAVVEKIMPEKALTSGITMSSEVVNRIFSNPEGNKKDPRVPKLGKMMENESPSAGLETGVNAEKVVPGGVPKQRKPPMVMTPPTCTDHSARKLPEIQHPKFAAKRRWTCSKPKPTSLLREAVMATSDKLMVEPPSAYPITPSSPLYTNTDSLTVITPVKKKRGRPKKQPLLTVETIHEGTSTSPVSPISREFPGTKKRKRRRSLAKLAQLVPGEDKPMSEMKFHKKVGKLGVLDKKTIKTINKMKTLKRKNILNQILSCSSSIALKAKAPPETSPGAAAIESKLGKQINVSKRGTIYIGKKRGRKPRAELPPPSEEPKTAIKHPRPVSSQPDVPAVPSNLQSLVASSPAAMHPLSTQLGGSNGNLSPASTETNFSELKTMPNLQPISALPTKTQKGIHSGTWKLSPPRLMANSPSHLCEIGSLKEITLSPVSESHSEETIPSDSGIGTDNNSTSDQAEKSSESRRRYSFDFCSLDNPEAIPSDTSTKNRHGHRQKHLIVDNFLAHESLKKPKHKRKRKSLQNRDDLQFLADLEELITKFQVFRISHRSYTFYHENPYPSIFRINFDHYYPVPYIQYDPLLYLRRTSDLKSKKKRGRPAKTNDTMTKVPFLQGFSYPIPSGSYYAPYGMPYTSMPMMNLGYYSQYPAPVYLSHTLGAASPFMRPTVPPPQFHTSSHVKMSGTAKHKAKHGVHLQGPVGMGLGDRQPSLNPPKVGSASLSSGRLHKRKHKHKHKHKEDRLLGTHDNLSGLFAGKATGFSSHILSERLSSADKELSLVSEKNKHKEKQKHQHSEASHKASKNNFEVDTLSTLSLSDAQHWTQAKDKGDLSSEPADSCAKRYSGNGGDGGGARPESLDVFSEMNPPNDKWDSDVSASKRRSYEGFGTYREKDIQAFKMNRKERSPYDSSVSPGIPSPHLKVDQTATHGKNESSASTVMTRKKPATVDSVAIPPAPVLSLLAASAATSDAASSSLKKRFKRREIEAIQCEVRKMCNYTKILSTKKNLDHVNKILKAKRLQRQSKTGNNFVKKRRGRPRKQPTQFDEDSRDQMPVLEKCIDLPSKRGQKPSLSPLVLEPAASQDTIMATIEAVIHMAREAPPLPPPPP", "length": 1525, "header": "tr|A0A3Q1MXX5-1|F1MHB3_BOVIN Computationally mapped isoform of SET binding protein 1 OS=Bos taurus OX=9913 GN=SETBP1 PE=4 SV=2 CANONICAL=F1MHB3-1" }, "locus": { "chromosome": "24", "start_pos": 44681112, "end_pos": 44299029, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079033.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079033.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060730.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060730.2" } ] } }, { "isoform_ac": "A0AAA9RWZ4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWZ4/entry", "sequence": { "sequence": "MESREVLSGSRQRVSESEFLPVSSAKPSTTPSCTGEPLLSAPETGKGIPAGGERMEPEEEDELGSGRDVDSNSNADSEKWVAGDGLEEQEFSIKEANFTEGSLKLKIQTTKRAKKPPKNLENYICPPEIKITIKQSDQKVSRAGKNSKATKEEDRSHSKKKLLTASDLAASDLKGFQPQAYERPQKHSALHYDPGLPQDFTSDTLKPKHQQKSSSQNHMDWSTNSDNGPATQNCFISPESGRETASTSKIPALEPMASFAKAQGKKGSAGSTWNQLPNSNKDLLLGGVVPSPSNHSSPAPPSSSAECSGIQPLVDQDGGSTKEPLEPPTISSKKKSSKKDVISQTIPNSDLDWVKNAQKAFDSTEGKREGYSADSAQEASPARQNVSSVSNPENDSSHVRITIPIKAPCLDPSSHKRKKRQSIKAVVEKIMPEKALTSGITMSSEVVNRIFSNPEGNKKDPRVPKLGKMMENESPSAGLETGVNAEKVVPGGVPKQRKPPMVMTPPTCTDHSARKLPEIQHPKFAAKRRWTCSKPKPTSLLREAVMATSDKLMVEPPSAYPITPSSPLYTNTDSLTVITPVKKKRGRPKKQPLLTVETIHEGTSTSPVSPISREFPGTKKRKRRRSLAKLAQLVPGEDKPMSEMKFHKKVGKLGVLDKKTIKTINKMKTLKRKNILNQILSCSSSIALKAKAPPETSPGAAAIESKLGKQINVSKRGTIYIGKKRGRKPRAELPPPSEEPKTAIKHPRPVSSQPDVPAVPSNLQSLVASSPAAMHPLSTQLGGSNGNLSPASTETNFSELKTMPNLQPISALPTKTQKGIHSGTWKLSPPRLMANSPSHLCEIGSLKEITLSPVSESHSEETIPSDSGIGTDNNSTSDQAEKSSESRRRYSFDFCSLDNPEAIPSDTSTKNRHGHRQKHLIVDNFLAHESLKKPKHKRKRKSLQNRDDLQFLADLEELITKFQVFRISHRSYTFYHENPYPSIFRINFDHYYPVPYIQYDPLLYLRRTSDLKSKKKRGRPAKTNDTMTKVPFLQGFSYPIPSGSYYAPYGMPYTSMPMMNLGYYSQYPAPVYLSHTLGAASPFMRPTVPPPQFHTSSHVKMSGTAKHKAKHGVHLQGPVGMGLGDRQPSLNPPKVGSASLSSGRLHKRKHKHKHKHKEDRLLGTHDNLSGLFAGKATGFSSHILSERLSSADKELSLVSEKNKHKEKQKHQHSEASHKASKNNFEVDTLSTLSLSDAQHWTQAKDKGDLSSEPADSCAKRYSGNGGDGGGARPESLDVFSEMNPPNDKWDSDVSASKRRSYEGFGTYREKDIQAFKMNRKERSPYDSSVSPASSSLKKRFKRREIEAIQCEVRKMCNYTKILSTKKNLDHVNKILKAKRLQRQSKTGNNFVKKRRGRPRKQPTQFDEDSRDQMPVLEKCIDLPSKRGQKPSLSPLVLEPAASQDTIMATIEAVIHMAREAPPLPPPPPPPLPPPPPPPPPPPPPLPKTPRGGGKRKHKPQPPAQPPQQAPPPQPLPPEEEVKAKRQRKSRGSESDVLP", "length": 1538, "header": "tr|A0AAA9RWZ4-1|F1MHB3_BOVIN Computationally mapped isoform of SET binding protein 1 OS=Bos taurus OX=9913 GN=SETBP1 PE=4 SV=1 CANONICAL=F1MHB3-1" }, "locus": { "chromosome": "24", "start_pos": 44681322, "end_pos": 44299029, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120782.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120782.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077997.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077997.1" } ] } }, { "isoform_ac": "A0AAA9T9B5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9B5/entry", "sequence": { "sequence": "MESREVLSGSRQRVSESEFLPVSSAKPSTTPSCTGEPLLSAPETGKGIPAGGERMEPEEEDELGSGRDVDSNSNADSEKWVAGDGLEEQEFSIKEANFTEGSLKLKIQTTKRAKKPPKNLENYICPPEIKITIKQSDQKVSRAGKNSKATKEEDRSHSKKKLLTASDLAASDLKGFQPQAYERPQKHSALHYDPGLPQDFTSDTLKPKHQQKSSSQNHMDWSTNSDNGPATQNCFISPESGRETASTSKIPALEPMASFAKAQGKKGSAGSTWNQLPNSNKDLLLGGVVPSPSNHSSPAPPSSSAECSGIQPLVDQDGGSTKEPLEPPTISSKKKSSKKDVISQTIPNSDLDWVKNAQKAFDSTEGKREGYSADSAQEASPARQNVSSVSNPENDSSHVRITIPIKAPCLDPSSHKRKKRQSIKAVVEKIMPEKALTSGITMSSEVVNRIFSNPEGNKKDPRVPKLGKMMENESPSAGLETGVNAEKVVPGGVPKQRKPPMVMTPPTCTDHSARKLPEIQHPKFAAKRRWTCSKPKPTSLLREAVMATSDKLMVEPPSAYPITPSSPLYTNTDSLTVITPVKKKRGRPKKQPLLTVETIHEGTSTSPVSPISREFPGTKKRKRRRSLAKLAQLVPGEDKPMSEMKFHKKVGKLGVLDKKTIKTINKMKTLKRKNILNQILSCSSSIALKAKAPPETSPGAAAIESKLGKQINVSKRGTIYIGKKRGRKPRAELPPPSEEPKTAIKHPRPVSSQPDVPAVPSNLQSLVASSPAAMHPLSTQLGGSNGNLSPASTETNFSELKTMPNLQPISALPTKTQKGIHSGTWKLSPPRLMANSPSHLCEIGSLKEITLSPVSESHSEETIPSDSGIGTDNNSTSDQAEKSSESRRRYSFDFCSLDNPEAIPSDTSTKNRHGHRQKHLIVDNFLAHESLKKPKHKRKRKSLQNRDDLQFLADLEELITKFQVFRISHRSYTFYHENPYPSIFRINFDHYYPVPYIQYDPLLYLRRTSDLKSKKKRGRPAKTNDTMTKVPFLQGFSYPIPSGSYYAPYGMPYTSMPMMNLGYYSQYPAPVYLSHTLGAASPFMRPTVPPPQFHTSSHVKMSGTAKHKAKHGVHLQGPVGMGLGDRQPSLNPPKVGSASLSSGRLHKRKHKHKHKHKEDRLLGTHDNLSGLFAGKATGFSSHILSERLSSADKELSLVSEKNKHKEKQKHQHSEASHKASKNNFEVDTLSTLSLSDAQHWTQAKDKGDLSSEPADSCAKRYSGNGGDGGGARPESLDVFSEMNPPNDKWDSDVSASKRRSYEGFGTYREKDIQAFKMNRKERSPYDSSVSPGIPSPHLKVDQTATHGKNESSASTVMTRKKPATVDSVAIPPAPVLSLLAASAATSDAGLENCLWIKEKSSSSLKKRFKRREIEAIQCEVRKMCNYTKILSTKKNLDHVNKILKAKRLQRQSKTGNNFVKKRRGRPRKQPTQFDEDSRDQMPVLEKCIDLPSKRGQKPSLSPLVLEPAASQDTIMATIEAVIHMAREAPPLPPPPPPP", "length": 1538, "header": "tr|A0AAA9T9B5-1|F1MHB3_BOVIN Computationally mapped isoform of SET binding protein 1 OS=Bos taurus OX=9913 GN=SETBP1 PE=4 SV=1 CANONICAL=F1MHB3-1" }, "locus": { "chromosome": "24", "start_pos": 44681118, "end_pos": 44299029, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102220.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102220.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095290.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095290.1" } ] } }, { "isoform_ac": "F1MHB3-1", "url": "https://www.uniprot.org/uniprotkb/F1MHB3/entry", "sequence": { "sequence": "MESREVLSGSRQRVSESEFLPVSSAKPSTTPSCTGEPLLSAPETGKGIPAGGERMEPEEEDELGSGRDVDSNSNADSEKWVAGDGLEEQEFSIKEANFTEGSLKLKIQTTKRAKKPPKNLENYICPPEIKITIKQSDQKVSRAGKNSKATKEEDRSHSKKKLLTASDLAASDLKGFQPQAYERPQKHSALHYDPGLPQDFTSDTLKPKHQQKSSSQNHMDWSTNSDNGPATQNCFISPESGRETASTSKIPALEPMASFAKAQGKKGSAGSTWNQLPNSNKDLLLGGVVPSPSNHSSPAPPSSSAECSGIQPLVDQDGGSTKEPLEPPTISSKKKSSKKDVISQTIPNSDLDWVKNAQKAFDSTEGKREGYSADSAQEASPARQNVSSVSNPENDSSHVRITIPIKAPCLDPSSHKRKKRQSIKAVVEKIMPEKALTSGITMSSEVVNRIFSNPEGNKKDPRVPKLGKMMENESPSAGLETGVNAEKVVPGGVPKQRKPPMVMTPPTCTDHSARKLPEIQHPKFAAKRRWTCSKPKPTSLLREAVMATSDKLMVEPPSAYPITPSSPLYTNTDSLTVITPVKKKRGRPKKQPLLTVETIHEGTSTSPVSPISREFPGTKKRKRRRSLAKLAQLVPGEDKPMSEMKFHKKVGKLGVLDKKTIKTINKMKTLKRKNILNQILSCSSSIALKAKAPPETSPGAAAIESKLGKQINVSKRGTIYIGKKRGRKPRAELPPPSEEPKTAIKHPRPVSSQPDVPAVPSNLQSLVASSPAAMHPLSTQLGGSNGNLSPASTETNFSELKTMPNLQPISALPTKTQKGIHSGTWKLSPPRLMANSPSHLCEIGSLKEITLSPVSESHSEETIPSDSGIGTDNNSTSDQAEKSSESRRRYSFDFCSLDNPEAIPSDTSTKNRHGHRQKHLIVDNFLAHESLKKPKHKRKRKSLQNRDDLQFLADLEELITKFQVFRISHRSYTFYHENPYPSIFRINFDHYYPVPYIQYDPLLYLRRTSDLKSKKKRGRPAKTNDTMTKVPFLQGFSYPIPSGSYYAPYGMPYTSMPMMNLGYYSQYPAPVYLSHTLGAASPFMRPTVPPPQFHTSSHVKMSGTAKHKAKHGVHLQGPVGMGLGDRQPSLNPPKVGSASLSSGRLHKRKHKHKHKHKEDRLLGTHDNLSGLFAGKATGFSSHILSERLSSADKELSLVSEKNKHKEKQKHQHSEASHKASKNNFEVDTLSTLSLSDAQHWTQAKDKGDLSSEPADSCAKRYSGNGGDGGGARPESLDVFSEMNPPNDKWDSDVSASKRRSYEGFGTYREKDIQAFKMNRKERSPYDSSVSPGIPSPHLKVDQTATHGKNESSASTVMTRKKPATVDSVAIPPAPVLSLLAASAATSDAASSSLKKRFKRREIEAIQCEVRKMCNYTKILSTKKNLDHVNKILKAKRLQRQSKTGNNFVKKRRGRPRKQPTQFDEDSRDQMPVLEKCIDLPSKRGQKPSLSPLVLEPAASQDTIMATIEAVIHMAREAPPLPPPPPPPLPPPPPPPPPPPPPLPKTPRGGGKRKHKPQPPAQPPQQAPPPQPLPPEEEVKAKRQRKSRGSESDVLP", "length": 1595, "header": "tr|F1MHB3-1|F1MHB3_BOVIN Isoform 1 of SET binding protein 1 OS=Bos taurus OX=9913 GN=SETBP1 PE=4 SV=3 CANONICAL=F1MHB3-1" }, "locus": { "chromosome": "24", "start_pos": 44681322, "end_pos": 44299029, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024078.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024078.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024078.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024078.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 563, "start_aa": "Thr", "end_pos": 563, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr563", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:617265", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617265", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MHB3", "url": "https://www.uniprot.org/uniprotkb/F1MHB3" } ], "pmid": "" }, { "name": "histone H3K4 methyltransferase activity", "id": "GO:0042800", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042800", "evidence": [ { "database": "UniProtKB", "id": "F1MHB3", "url": "https://www.uniprot.org/uniprotkb/F1MHB3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MHB3", "url": "https://www.uniprot.org/uniprotkb/F1MHB3" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MHB3", "url": "https://www.uniprot.org/uniprotkb/F1MHB3" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "F1MHB3", "url": "https://www.uniprot.org/uniprotkb/F1MHB3" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "F1MHB3", "url": "https://www.uniprot.org/uniprotkb/F1MHB3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1MHB3", "url": "https://www.uniprot.org/uniprotkb/F1MHB3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1024, "end_pos": 1026, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1167, "end_pos": 1169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1349, "end_pos": 1351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1414, "end_pos": 1416, "annotation": "n_glycosylation_sequon" }, { "start_pos": 294, "end_pos": 296, "annotation": "n_glycosylation_sequon" }, { "start_pos": 385, "end_pos": 387, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" }, { "start_pos": 472, "end_pos": 474, "annotation": "n_glycosylation_sequon" }, { "start_pos": 712, "end_pos": 714, "annotation": "n_glycosylation_sequon" }, { "start_pos": 787, "end_pos": 789, "annotation": "n_glycosylation_sequon" }, { "start_pos": 796, "end_pos": 798, "annotation": "n_glycosylation_sequon" }, { "start_pos": 873, "end_pos": 875, "annotation": "n_glycosylation_sequon" }, { "start_pos": 874, "end_pos": 876, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 563 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1024, "end_pos": 1026 }, { "start_pos": 1167, "end_pos": 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GN=MTSS2 PE=3 SV=2 CANONICAL=F1MGT3-1" }, "locus": { "chromosome": "18", "start_pos": 1508024, "end_pos": 1488712, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073898.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073898.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062194.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062194.2" } ] } }, { "isoform_ac": "F1MGT3-1", "url": "https://www.uniprot.org/uniprotkb/F1MGT3/entry", "sequence": { "sequence": "MGRRPPGLPADPSPRPAPRAHVTPRPPRSGYGRRASPRAEAAPPAARAAPPALPASPAATWPAPPRGGPRPPSAVRPAAERGPEAAGPARPRSDSRRGAGPSALPAPPPGPSMETAEKECGALGGLFQAIVNDMKSSYPIWEDFNSKATKLHSQLRTTVLAAVAFLDAFQKVADMATNTRGATRDIGSALTRMCMRHRSIETKLRQFTNALLESLINPLQERIEDWKKSANQLDKDHAKEYKRARHEIKKKSSDTLKLQKKARKELLGKGDLQPQLDSALQDVNDMYLLLEETEKQAVRRALIEERGRFCTFITFLQPVVNGELTMLGEITHLQGIIDDLVVLTAEPHKLPPASEQVITDLKGSDYSWSYQTPPSSPSSSSSRKSSMCSAPSSGSSAKGGGGPWPGGAQTCSPGPACRYRSLAQPAPAARLSSVSSHDSGFVSQEATYSKPPSPMPSDITSQKSSSSASSEASETCQSVSECSSPTSDWAKAGPHEQPAGTALQRRKDRVELLRDPELGPAGGGAPGPSGEEAPRPRMSPATIAAKHGEEVSPAASDLAMVLTRGLSLEHQKSSRDSLQYSSGYSTQTTTPSCSEDTIPSQGSDYDCYSVNGDADGEGPPEFDKSSTIPRNSNIAQNYRRLIQTKRPASTAGLPTASGAPPGVATIRRTPSTKPTVRRALSSAGPIPIRPPIVPVKTPTVPDSPGYVGPTRAGSEECVFYTDEAAAALAPDLAKASPKRLSLPNTAWGSPSPEAAGYAGLAAQDDEEQQQQLAANRHSLVEKLGELVAGAHALAEGQFPFPSALSAAPAEGTPAPPPAAPGEPPAEDMLVAIRRGVRLRRTVTNDRSAPRIL", "length": 852, "header": "tr|F1MGT3-1|F1MGT3_BOVIN Isoform 1 of MTSS I-BAR domain containing 2 OS=Bos taurus OX=9913 GN=MTSS2 PE=3 SV=4 CANONICAL=F1MGT3-1" }, "locus": { "chromosome": "18", "start_pos": 1508024, "end_pos": 1488712, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012316.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012316.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012316.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012316.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 23, "start_aa": "Thr", "end_pos": 23, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr23", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": 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"evidence": [ { "database": "UniProtKB", "id": "F1MGT3", "url": "https://www.uniprot.org/uniprotkb/F1MGT3" } ], "pmid": "" }, { "name": "cellular response to platelet-derived growth factor stimulus", "id": "GO:0036120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036120", "evidence": [ { "database": "UniProtKB", "id": "F1MGT3", "url": "https://www.uniprot.org/uniprotkb/F1MGT3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MGT3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 852, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MGT3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MGT3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MGT3", "database": "UniProtKB", 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"relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPZ7-1", "uniprot_ac": "E1BPZ7", "uniprot_id": "E1BPZ7_BOVIN", "mass": { "chemical_mass": 135020.0, "monoisotopic_mass": 135020.0 }, "refseq": { "ac": "XP_024850124", "name": "F-box only protein 38 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850124" }, "gene_names": [ { "name": "FBXO38", "type": "recommended", "evidence": [ { "id": "E1BPZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPZ7" } ] }, { "name": "FBXO38", "type": "synonym", "evidence": [ { "id": "XP_024850124", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850124" } ] } ], "protein_names": [ { "name": "F-box only protein 38 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024850124", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850124" } ] }, { "name": "F-box protein 38", "type": "synonym", "evidence": [ { "id": "E1BPZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPZ7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPZ7", "url": "https://www.uniprot.org/uniprotkb/E1BPZ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBXO38", "url": "https://www.uniprot.org/uniprotkb/E1BPZ7", "locus": { "chromosome": "7", "start_pos": 59865455, "end_pos": 59808734, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020303", "url": "https://www.ensembl.org/id/ENSBTAG00000020303" } ] } } ], "crossref": [ { "id": "E1BPZ7", "url": "https://alphafold.ebi.ac.uk/entry/E1BPZ7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020303", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020303", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22107", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22107", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533554", "url": "https://www.ncbi.nlm.nih.gov/gene/533554", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042354", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042354", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BPZ7", "url": "https://www.orthodb.org/?gene=E1BPZ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14753", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14753", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14753:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14753:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00646", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00646", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024850124", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850124", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N848", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N848", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N848-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N848-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW68", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TW68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW68-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPZ7", "url": "https://www.uniprot.org/uniprotkb/E1BPZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPZ7-1", "url": "https://www.uniprot.org/uniprotkb/E1BPZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPRKKSVKTCLVNNEIPEEAVSDETKDYMNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDSSFLTLLKKMPDVEQLYGLHPRYLERRRVRGHEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMPHVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWVRLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLGGLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKDGVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGMKAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWTRLVDINLVRCHALKLDSFGQFIELLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDNDNNAQNNANIHDNNHHHPDDSDEENDFRQDLQPGEQQFAADALNEMEDMVQEDGEVMAESGHETPAHSQAVVPVDVDEEQAGPSGLQRVVKPTPITVHDSESDDEEDSLELQEVWIPKNGARRFSEREEKTGESVQSRELSVSGKGKTPLRKRYNSHQMGQSKQFPLEESSCEKGCQVTSEQIKADMKAARDIPEKKKNKDVYPSCSSTTASTVGNSSSHSTASQSPDFVRTVNSSGSSEPSPTEVDVSRQCVCSPGGSEDSEAMEEGDAESSVCPRCCCHRPQESQRRTSRCSDEERPSTSRACVVNGPDGTRSAFSFRTLPQGGSSGPAHDERTNGSGSGATGEDRRGSSQPERCDVQSNEDYPRRPLTRARSRLSHVPLVSESGMTMLPGLATAEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEDDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSADICMETIGEEISEMRQMKKGVFQRVVAIFIHYCDVNGEPVEDDYI", "length": 1199, "header": "tr|E1BPZ7-1|E1BPZ7_BOVIN Isoform 1 of F-box protein 38 OS=Bos taurus OX=9913 GN=FBXO38 PE=4 SV=3 CANONICAL=E1BPZ7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N848-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N848/entry", "sequence": { "sequence": "MGPRKKSVKTCLVNNEIPEEAVSDETKDYMNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDSSFLTLLKKMPDVEQLYGLHPRYLERRRVRGHEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMPHVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWVRLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLGGLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKDGVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGMKAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWTRLVDINLVRCHALKLDSFGQFIELLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDNDNNAQNNANIHDNNHHHPDDSDEENDFRQDLQPGEQQFAADALNEMEDMVQEDGEVMAESGHETPAHSQAVVPVDVDEEQAGPSGLQRVVKPTPITVHDSESDDEEDSLELQEVWIPKNGARRFSEREEKTGESVQSRELSVSGKGKTPLRKRYNSHQMGQSKQFPLEESSCEKGCQVTSEQIKADMKAARDIPEKKKNKDVYPSCSSTTASTVGNSSSHSTASQSPDFVRTVNSSGSSEPSPTEVDVSRQCVCSPGGSEDSEAMEEGDAESSVCPRCCCHRPQESQRRTSRCSDEERPSTSRACVVNGPDGEDRRGSSQPERCDVQSNEDYPRRPLTRARSRLSHVPLVSESEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEDDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSADICMETIGEEISEMRQMKKGVFQRVVAIFIHYCDVNGEPVEDDYI", "length": 1155, "header": "tr|A0A3Q1N848-1|E1BPZ7_BOVIN Computationally mapped isoform of F-box protein 38 OS=Bos taurus OX=9913 GN=FBXO38 PE=4 SV=1 CANONICAL=E1BPZ7-1" }, "locus": { "chromosome": "7", "start_pos": 59864767, "end_pos": 59808831, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082253.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082253.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067102.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067102.2" } ] } }, { "isoform_ac": "A0AAA9TW68-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW68/entry", "sequence": { "sequence": "MGPRKKSVKTCLVNNEIPEEAVSDETKDYMNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDSSFLTLLKKMPDVEQLYGLHPRYLERRRVRGHEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMPHVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWVRLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLGGLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKDGVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGMKAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWTRLVDINLVRCHALKLDSFGQFIELLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDNDNNAQNNANIHDNNHHHPDDSDEENDFRQDLQPGEQQFAADALNEMEDMVQEDGEVMAESGHETPAHSQAVVPVDVDEEQAGPSGLQRVVKPTPITVHDSESDDEEDSLELQEVWIPKNGARRFSEREEKTGESVQSRELSEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEDDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSADICMETIGEEISEMRQMKKGVFQRVVAIFIHYCDVNGEPVEDDYI", "length": 943, "header": "tr|A0AAA9TW68-1|E1BPZ7_BOVIN Computationally mapped isoform of F-box protein 38 OS=Bos taurus OX=9913 GN=FBXO38 PE=4 SV=1 CANONICAL=E1BPZ7-1" }, "locus": { "chromosome": "7", "start_pos": 59864767, "end_pos": 59808831, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105825.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105825.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100859.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100859.1" } ] } }, { "isoform_ac": "E1BPZ7-1", "url": "https://www.uniprot.org/uniprotkb/E1BPZ7/entry", "sequence": { "sequence": "MGPRKKSVKTCLVNNEIPEEAVSDETKDYMNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDSSFLTLLKKMPDVEQLYGLHPRYLERRRVRGHEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMPHVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWVRLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLGGLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKDGVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGMKAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWTRLVDINLVRCHALKLDSFGQFIELLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDNDNNAQNNANIHDNNHHHPDDSDEENDFRQDLQPGEQQFAADALNEMEDMVQEDGEVMAESGHETPAHSQAVVPVDVDEEQAGPSGLQRVVKPTPITVHDSESDDEEDSLELQEVWIPKNGARRFSEREEKTGESVQSRELSVSGKGKTPLRKRYNSHQMGQSKQFPLEESSCEKGCQVTSEQIKADMKAARDIPEKKKNKDVYPSCSSTTASTVGNSSSHSTASQSPDFVRTVNSSGSSEPSPTEVDVSRQCVCSPGGSEDSEAMEEGDAESSVCPRCCCHRPQESQRRTSRCSDEERPSTSRACVVNGPDGTRSAFSFRTLPQGGSSGPAHDERTNGSGSGATGEDRRGSSQPERCDVQSNEDYPRRPLTRARSRLSHVPLVSESGMTMLPGLATAEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEDDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSADICMETIGEEISEMRQMKKGVFQRVVAIFIHYCDVNGEPVEDDYI", "length": 1199, "header": "tr|E1BPZ7-1|E1BPZ7_BOVIN Isoform 1 of F-box protein 38 OS=Bos taurus OX=9913 GN=FBXO38 PE=4 SV=3 CANONICAL=E1BPZ7-1" }, "locus": { "chromosome": "7", "start_pos": 59864767, "end_pos": 59808831, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027060.8", "url": "https://www.ensembl.org/id/ENSBTAT00000027060.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027060.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027060.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0031146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031146", "evidence": [ { "database": "UniProtKB", "id": "E1BPZ7", "url": "https://www.uniprot.org/uniprotkb/E1BPZ7" } ], "pmid": "" }, { "name": "positive regulation of T cell mediated immune response to tumor cell", "id": "GO:0002842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002842", "evidence": [ { "database": "UniProtKB", "id": "E1BPZ7", "url": "https://www.uniprot.org/uniprotkb/E1BPZ7" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "E1BPZ7", "url": "https://www.uniprot.org/uniprotkb/E1BPZ7" } ], "pmid": "" }, { "name": "positive regulation of T cell activation", "id": "GO:0050870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050870", "evidence": [ { "database": "UniProtKB", "id": "E1BPZ7", "url": "https://www.uniprot.org/uniprotkb/E1BPZ7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BPZ7", "url": "https://www.uniprot.org/uniprotkb/E1BPZ7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BPZ7", "url": "https://www.uniprot.org/uniprotkb/E1BPZ7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "E1BPZ7", "url": "https://www.uniprot.org/uniprotkb/E1BPZ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 714, "end_pos": 716, "annotation": "n_glycosylation_sequon" }, { "start_pos": 732, "end_pos": 734, "annotation": "n_glycosylation_sequon" }, { "start_pos": 835, "end_pos": 837, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], 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Classification" ] }, { "id": "IPR044666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059998", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059998", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DDWYDVY", "url": "https://omabrowser.org/oma/group/DDWYDVY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45625", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45625", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45625:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45625:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00160", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00160", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059734662", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734662", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RRL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RRL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRL4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ45", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZ45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T999", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T999", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T999-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T999-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDB0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN63", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBE0", "url": "https://www.uniprot.org/uniprotkb/F1MBE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBE0-1", "url": "https://www.uniprot.org/uniprotkb/F1MBE0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGTGGESIYGVPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKVTGDTVYNMLRLTEVDIDDEERPRNPHKIRSCEVLFNPFDDIIPREIKKPKKEKPEEEVKKLKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPAVESERGDAAEDSDDDGEYEGAEHDEYVDGDEKNQMRERIAKKLKKDTSENVKRAGEGEVEKKPVSRSEELRKEARQLKRELLAAKQKKAENSAIQAEKRSEEEEAAPDGAVAEYRREKQKYEALRKQQAKTGTSREDQTLALLNQFKSKLTQAIAETPENDISETEVEDDEGWMSHVLQFEDKSRKVKDASMQDSDTFEIYDPRNPVNKRRREESKKLMREKKERR", "length": 473, "header": "tr|F1MBE0-1|F1MBE0_BOVIN Isoform 1 of Spliceosome-associated protein CWC27 homolog OS=Bos taurus OX=9913 GN=CWC27 PE=3 SV=3 CANONICAL=F1MBE0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RRL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRL4/entry", "sequence": { "sequence": "MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGTGGESIYGVPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKVTGDTVYNMLRLTEVDIDDEERPRNPHKIRSCEVLFNPFDDIIPREIKKPKKEKPEEEVKKLKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPAVESERGDAAEDSDDDGEYEGAEHDEYVDGDEKNQMRERIAKKLKKDTSENVKRAGEGEVEKKPVSRSEELRKEARQLKRELLAAKQKKAENSAIQAEKRSEEEEAAPDGAVAEYRREKQKYEALRKQQAKTGTSREDQTLALLNQFKSKLTQAIAETPENDISETEVEDDEGCHLTRKSGEGNGTPLQYSCLENPMDGEAW", "length": 448, "header": "tr|A0AAA9RRL4-1|F1MBE0_BOVIN Computationally mapped isoform of Spliceosome-associated protein CWC27 homolog OS=Bos taurus OX=9913 GN=CWC27 PE=3 SV=1 CANONICAL=F1MBE0-1" }, "locus": { "chromosome": "20", "start_pos": 14726144, "end_pos": 14496828, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097511.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097511.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074805.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074805.1" } ] } }, { "isoform_ac": "A0AAA9RVC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVC3/entry", "sequence": { "sequence": "MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGTGGESIYGVPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKVTGDTVYNMLRLTEVDIDDEERPRNPHKIRSCEVLFNPFDDIIPREIKKPKKEKPEEEVKKLKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPAVESERGDAAEDSDDDGEYEGAEHDEYVDGDEKNQMRERIAKKLKKDTSENVKRAGEGEVEKKPVSRSEELRKEARQLKRELLAAKQKKAENSAIQAEKRSEEEEAAPDGAVAEYRREKQKYEALRKQQAKTGTSREDQGEQPVTWI", "length": 393, "header": "tr|A0AAA9RVC3-1|F1MBE0_BOVIN Computationally mapped isoform of Spliceosome-associated protein CWC27 homolog OS=Bos taurus OX=9913 GN=CWC27 PE=3 SV=1 CANONICAL=F1MBE0-1" }, "locus": { "chromosome": "20", "start_pos": 14726144, "end_pos": 14371110, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118013.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118013.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077263.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077263.1" } ] } }, { "isoform_ac": "A0AAA9RZ45-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ45/entry", "sequence": { "sequence": "MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGTGGESIYGVPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKVTGDTVYNMLRLTEVDIDDEERPRNPHKIRSCEVLFNPFDDIIPREIKKPKKEKPEEEVKKLKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPAVESERGDAAEDSDDDGEYEGAEHDEYVDGDEKNQMRERIAKKLKKDTSENVKRAGEGEVEKKPVSRSKC", "length": 316, "header": "tr|A0AAA9RZ45-1|F1MBE0_BOVIN Computationally mapped isoform of Spliceosome-associated protein CWC27 homolog OS=Bos taurus OX=9913 GN=CWC27 PE=3 SV=1 CANONICAL=F1MBE0-1" }, "locus": { "chromosome": "20", "start_pos": 14726144, "end_pos": 14657531, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110285.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110285.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077904.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077904.1" } ] } }, { "isoform_ac": "A0AAA9T999-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T999/entry", "sequence": { "sequence": "MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGTGGESIYGVPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKVTGDTVYNMLRLTEVDIDDEERPRNPHKIRSCEVLFNPFDDIIPREIKKPKKEKPEEEVKKLKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPAVESERGDAAEDSDDDGEYEGAEHDEYVDGDEKNQMRERIAKKLKKDTSENVKRAGEGEVEKKPVSRSEELRKEARQLKRELLAAKQKKAENSAIQAEKRSEEEEAAPDGAVAEYRREKQKYEALRKQQAKTGTSREDQDVACTSV", "length": 392, "header": "tr|A0AAA9T999-1|F1MBE0_BOVIN Computationally mapped isoform of Spliceosome-associated protein CWC27 homolog OS=Bos taurus OX=9913 GN=CWC27 PE=3 SV=1 CANONICAL=F1MBE0-1" }, "locus": { "chromosome": "20", "start_pos": 14726144, "end_pos": 14466554, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123904.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123904.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095268.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095268.1" } ] } }, { "isoform_ac": "A0AAA9TDB0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDB0/entry", "sequence": { "sequence": "MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGTGGESIYGVPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKVTGDTVYNMLRLTEVDIDDEERPRNPHKIRSCEVLFNPFDDIIPREIKKPKKEKPEEEVKKLKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPAVESERGDAAEDSDDDGEYEGAEHDEYVDGDEKNQMRERIAKKLKKDTSENVKRAGEGEVEKKPVSRSEELRKEARQLKRELLAAKQKKAENSAIQAEKRSEEEEAAPDGAVAEYRREKQKYEALRKQQAKTGTSREDQTLALLNQFKSKLTQAIAETPENDISETEVEDDEGWRQETISRGLLLLFSHCAQLFATPQTAARQASQSLTICQSLLKPMSIESVMPSNHLILCRPLLHPPVNRGYSLFMVW", "length": 496, "header": "tr|A0AAA9TDB0-1|F1MBE0_BOVIN Computationally mapped isoform of Spliceosome-associated protein CWC27 homolog OS=Bos taurus OX=9913 GN=CWC27 PE=3 SV=1 CANONICAL=F1MBE0-1" }, "locus": { "chromosome": "20", "start_pos": 14726144, "end_pos": 14456749, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132063.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132063.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094742.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094742.1" } ] } }, { "isoform_ac": "A0AAA9TN63-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN63/entry", "sequence": { "sequence": "MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGTGGESIYGVPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKVLFNPFDDIIPREIKKPKKEKPEEEVKKLKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPAVESERGDAAEDSDDDGEYEGAEHDEYVDGDEKNQMRERIAKKLKKDTSENVKRAGEGEVEKKPVSRSEELRKEARQLKRELLAAKQKKAENSAIQAEKRSEEEEAAPDGAVAEYRREKQKYEALRKQQAKTGTSREDQTLALLNQFKSKLTQAIAETPENDISETEVEDDEGWMSHVLQFEDKSRKVKDASMQDSDTFEIYDPRNPVNKRRREESKKLMREKKERR", "length": 440, "header": "tr|A0AAA9TN63-1|F1MBE0_BOVIN Computationally mapped isoform of Spliceosome-associated protein CWC27 homolog OS=Bos taurus OX=9913 GN=CWC27 PE=3 SV=1 CANONICAL=F1MBE0-1" }, "locus": { "chromosome": "20", "start_pos": 14726144, "end_pos": 14466415, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134222.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134222.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099793.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099793.1" } ] } }, { "isoform_ac": "A0AAA9TWA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWA5/entry", "sequence": { "sequence": "MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGTGGESIYGVPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKVTGDTVYNMLRLTEVDIDDEERPRNPHKIRSCEVLFNPFDDIIPREIKKPKKEKPEEEVKKLKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPAVESERGDAAEDSDDDGEYEGAEHDEYVDGDEKNQMRERIAKKLKKDTSENVKRAGEGEVEKKPVSRSEELRKEARQLKRELLAAKQKKAENSAIQAEKRSEEEEAAPDGAVAEYRREKQKYEALRKQQAKTGTSREDQTLALLNQFKSKLTQAIAETPENDISETEVEDDEGCFQLRREEQHLITASLVHEMYDIYQVIDRNCKMQSNTASPFLCH", "length": 463, "header": "tr|A0AAA9TWA5-1|F1MBE0_BOVIN Computationally mapped isoform of Spliceosome-associated protein CWC27 homolog OS=Bos taurus OX=9913 GN=CWC27 PE=3 SV=1 CANONICAL=F1MBE0-1" }, "locus": { "chromosome": "20", "start_pos": 14726144, "end_pos": 14473233, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094044.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094044.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101727.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101727.1" } ] } }, { "isoform_ac": "F1MBE0-1", "url": "https://www.uniprot.org/uniprotkb/F1MBE0/entry", "sequence": { "sequence": "MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGTGGESIYGVPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKVTGDTVYNMLRLTEVDIDDEERPRNPHKIRSCEVLFNPFDDIIPREIKKPKKEKPEEEVKKLKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPAVESERGDAAEDSDDDGEYEGAEHDEYVDGDEKNQMRERIAKKLKKDTSENVKRAGEGEVEKKPVSRSEELRKEARQLKRELLAAKQKKAENSAIQAEKRSEEEEAAPDGAVAEYRREKQKYEALRKQQAKTGTSREDQTLALLNQFKSKLTQAIAETPENDISETEVEDDEGWMSHVLQFEDKSRKVKDASMQDSDTFEIYDPRNPVNKRRREESKKLMREKKERR", "length": 473, "header": "tr|F1MBE0-1|F1MBE0_BOVIN Isoform 1 of Spliceosome-associated protein CWC27 homolog OS=Bos taurus OX=9913 GN=CWC27 PE=3 SV=3 CANONICAL=F1MBE0-1" }, "locus": { "chromosome": "20", "start_pos": 14726144, "end_pos": 14466415, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000040.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000040.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000040.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000040.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1L1RWB5-1", "protein_name": "Spliceosome-associated protein CWC27 homolog", "gene_name": "CWC27", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSNIYIQEPPTNGKVLLRTTAGDIDIELWSKEAPKACRNFIQLCMEEYYNNTIFHRVVPGFIVQGGDPTGTGSGGDSIYGAPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKVTGDTIYNMLRLAEVEVDKEERPLSPHKIRSSEVLFNPFDDIVPRPNRKLKKEKPEEEDKKAKVKGTKNFNLLSFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPAVKSDAANEESYLSEEEDENDEDVDSAEGEAASNERFQMKERVAKKLKMDTNETVKLQLPEEETKTEKKTTSRSEELRKEARQLKRELLEAKQKKEEQTLKPKEKEEEEPAPNSVVEEYLQEKRKYEDKRKQQPKKGVSREDQTLALLDRFKSKLTQAIEETPENEVSESEIDTDEGWMSHVLQFEDRSRKVKDASMQDEDTFEIYDPRNPVTKRRREESKKIMREKKERR", "length": 477 }, "evidence": [ { "id": "F1MBE0", "url": "https://omabrowser.org/oma/group/F1MBE0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q3TKY6-1", "protein_name": "Spliceosome-associated protein CWC27 homolog", "gene_name": "Cwc27", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGTGGESIYGAPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKVTGDTVYNMLRLTEVDIDDEERPRNPHRIKSCEVLFNPFDDITPREIKKPKNEKPEEEVKKLKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGRSKSSHDLLKDDPHLSSVPAVESEKDDATGDLEDDGEDDSAERDEYMEDDEKNLMRERIAKRLKKDASASVKSAGDGEKKPASRSEELRKEARQLKRELLAAKQKKETAIKVEEGREEEEAAPDGAVAEYRREKQKYEALRKQQPKKGTSREDQTLALLSQFKSKLTQAITETPENSVPEAEVEDDEGWMSHVLQFEDKTRKVKDASMQDSDTFEIYDPRNPVNKRRREESKKLLREKKERR", "length": 469 }, "evidence": [ { "id": "F1MBE0", "url": "https://omabrowser.org/oma/group/F1MBE0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5XIB2-1", "protein_name": "Spliceosome-associated protein CWC27 homolog", "gene_name": "Cwc27", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGTGGESVYGAPFKDEFHSRLRFNRRGLVAMANAGPHDNGSQFFFTLGRADELNNKHTIFGKVTGDTVYNMLRLTEVDIDDEERPRNPHRIKSCEVLFNPFDDIIPREIKKPKKEKAEEEIKKLKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGRSKSSHDLLKDDPHLSSVPAVESEKDDATGDLEDDAEDDSVEHDGSMEEDEKNLMRERIAKRLKKDASANVKSAGDGEKKPASRSEELRKEARQLKRELLAAKQKKESATKAEKGSEEEEAVPDGPVAEYRREKQKYEALRKQQPKKGTSREDQTLALLSQFKSKLTQAITEMPENCAEAEVEDDEGWMSHVLQFEDKTRKVKDASMQDSDTFEIYDPRNPVNKRRREESKKLLREKKERR", "length": 468 }, "evidence": [ { "id": "F1MBE0", "url": "https://omabrowser.org/oma/group/F1MBE0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6UX04-1", "protein_name": "Spliceosome-associated protein CWC27 homolog", "gene_name": "CWC27", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSNIYIQEPPTNGKVLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGSGGESIYGAPFKDEFHSRLRFNRRGLVAMANAGSHDNGSQFFFTLGRADELNNKHTIFGKVTGDTVYNMLRLSEVDIDDDERPHNPHKIKSCEVLFNPFDDIIPREIKRLKKEKPEEEVKKLKPKGTKNFSLLSFGEEAEEEEEEVNRVSQSMKGKSKSSHDLLKDDPHLSSVPVVESEKGDAPDLVDDGEDESAEHDEYIDGDEKNLMRERIAKKLKKDTSANVKSAGEGEVEKKSVSRSEELRKEARQLKRELLAAKQKKVENAAKQAEKRSEEEEAPPDGAVAEYRREKQKYEALRKQQSKKGTSREDQTLALLNQFKSKLTQAIAETPENDIPETEVEDDEGWMSHVLQFEDKSRKVKDASMQDSDTFEIYDPRNPVNKRRREESKKLMREKKERR", "length": 472 }, "evidence": [ { "id": "F1MBE0", "url": "https://omabrowser.org/oma/group/F1MBE0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VTN7-1", "protein_name": "Spliceosome-associated protein CWC27 homolog", "gene_name": "Dmel\\CG10907", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSNIYIQEPPTSGKVLLKTTVGDIDIELWARECPKACRNFVQLCLEGYYKNTEFHRLVKGFIVQGGDPNGDGTGGESIYGQPFKDEFHSRLRYTRRGLVGMANSGKDDNGSQFFFTFAPTPELQNKNTLFGKITGDTIYNMLKLEDGIVDHQERPMHAHRIVSTEVLSNPFDDIVPRILSQPSTKSKKTKKERQGVKNFGLLSFGEEAEGDEEETNVYVKQNAGKAKSLHDVTDDPKLSKEPIRVPKVEKADIEEHLSDDCPEDSVKDKPSTASSDLIKMKLSKRSKSGADKKVQPVEEKSDSEDDEDVLLTREEEQSRKVSEEKSKIREEIASLKKQYQMDKQSKDKLVNGQEKAAKSNEIKGSSENHYINDFIESKEKYTAKVKLQPKGQSREAFTLSLLSKFRTKLDNLKQKSSSDDGESEPKDIDDRVVEQEIIGDDWLSHTLNFNSTTPVLAKDANKKGDDWYDAYDPRNPLNKRKRGETGSSKSSSGKSKSSKRDF", "length": 502 }, "evidence": [ { "id": "F1MBE0", "url": "https://omabrowser.org/oma/group/F1MBE0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MBE0", "url": "https://www.uniprot.org/uniprotkb/F1MBE0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MBE0", "url": "https://www.uniprot.org/uniprotkb/F1MBE0" } ], "pmid": "" }, { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "F1MBE0", "url": "https://www.uniprot.org/uniprotkb/F1MBE0" } ], "pmid": "" }, { "name": "U2-type precatalytic spliceosome", "id": "GO:0071005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071005", "evidence": [ { "database": "UniProtKB", "id": "F1MBE0", "url": "https://www.uniprot.org/uniprotkb/F1MBE0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "F1MBE0", "url": "https://www.uniprot.org/uniprotkb/F1MBE0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "peptidyl-prolyl cis-trans isomerase activity", "id": "GO:0003755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003755", "evidence": [ { "database": "UniProtKB", "id": "F1MBE0", "url": "https://www.uniprot.org/uniprotkb/F1MBE0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 109, "end_pos": 111, "annotation": "n_glycosylation_sequon" }, { "start_pos": 201, "end_pos": 203, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MBE0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 473, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MBE0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MBE0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MBE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBE0" }, { "id": "PS50072", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50072" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PPIase cyclophilin-type", "eco_id": "ECO_0000259", "start_pos": 19, "end_pos": 166, "start_aa": "Thr", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 201, "end_pos": 203 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MIY0-1", "uniprot_ac": "F1MIY0", "uniprot_id": "F1MIY0_BOVIN", "mass": { "chemical_mass": 40756.0, "monoisotopic_mass": 40756.0 }, "refseq": { "ac": "XP_005216006", "name": "protein RIC-3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216006" }, "gene_names": [ { "name": "RIC3", "type": "recommended", "evidence": [ { "id": "F1MIY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIY0" } ] }, { "name": "RIC3", "type": "synonym", "evidence": [ { "id": "XP_005216006", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216006" } ] } ], "protein_names": [ { "name": "RIC3 acetylcholine receptor chaperone", "type": "synonym", "evidence": [ { "id": "F1MIY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIY0/entry#names_and_taxonomy" } ] }, { "name": "protein RIC-3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005216006", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216006" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MIY0", "url": "https://www.uniprot.org/uniprotkb/F1MIY0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RIC3", "url": "https://www.uniprot.org/uniprotkb/F1MIY0", "locus": { "chromosome": "15", "start_pos": 44433237, "end_pos": 44368098, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004863", "url": "https://www.ensembl.org/id/ENSBTAG00000004863" } ] } } ], "crossref": [ { "id": "F1MIY0", "url": "https://alphafold.ebi.ac.uk/entry/F1MIY0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004863", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004863", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "516280", "url": "https://www.ncbi.nlm.nih.gov/gene/516280", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR026160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MIY0", "url": "https://www.orthodb.org/?gene=F1MIY0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21723", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21723", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21723:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21723:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15361", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15361", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005216006", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216006", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RUK6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL08", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIY0", "url": "https://www.uniprot.org/uniprotkb/F1MIY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIY0-1", "url": "https://www.uniprot.org/uniprotkb/F1MIY0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAYSTVQRVALASGLVLAVSLLLPKAFLSRGKRQEPPPAPEGKLGRFPPMMHQQQAPSDGQTPGARFQRSHLAEAFAKSKGSGGGAGAGSGGRGLMGQIIPIYGFGIFLYILYILFKLSRGKSTAEDRKCSTATPGNTHRKITNFELVQLQEKLKETEEAMEKLINRVGPNGESRAQTVTSDQEKRLLHQLREITRVMKEGKFIDRSTPEKEAEEAPYMEDWEGYPEETYPIYDLSDCIKHRQETILVDYPDSKEPSAEEIAERMGMLEEEESDRVGWAMPTEPRAQEDNSVTSCDPEPEPCSCWSPEEEDPAVLAENAGFGANSYSEQEETTNEVWPYDLRGEGSGISADKADPGGMLRKRHPQGLE", "length": 368, "header": "tr|F1MIY0-1|F1MIY0_BOVIN Isoform 1 of RIC3 acetylcholine receptor chaperone OS=Bos taurus OX=9913 GN=RIC3 PE=3 SV=3 CANONICAL=F1MIY0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUK6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK6/entry", "sequence": { "sequence": "MQIEGFGGKLGRFPPMMHQQQAPSDGQTPGARFQRSHLAEAFAKSKGSGGGAGAGSGGRGLMGQIIPIYGFGIFLYILYILFKLSRGKSTAEDRKCSTATPGNTHRKITNFELVQLQEKLKETEEAMEKLINRVGPNGERAQTVTSDQEKRLLHQLREITRVMKEGKFIDRSTPEKEAEEAPYMEDWEGYPEETYPIYDLSDCIKHRQETILVDYPDSKEPSAEEIAERMGMLEEEESDRVGWAMPTEPRAQEDNSVTSCDPEPEPCSCWSPEEEDPAVLAENAGFGANSYSEQEETTNEVWPYDLRGEGSGISADKADPGGMLRKRHPQGLE", "length": 333, "header": "tr|A0AAA9RUK6-1|F1MIY0_BOVIN Computationally mapped isoform of RIC3 acetylcholine receptor chaperone OS=Bos taurus OX=9913 GN=RIC3 PE=3 SV=1 CANONICAL=F1MIY0-1" }, "locus": { "chromosome": "15", "start_pos": 44427864, "end_pos": 44401233, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120895.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120895.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076901.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076901.1" } ] } }, { "isoform_ac": "A0AAA9SL08-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL08/entry", "sequence": { "sequence": "MAYSTVQRVALASGLVLAVSLLLPKAFLSRGKRQEPPPAPEGKLGRFPPMMHQQQAPSDGQTPGARFQRSHLAEAFAKSKGSGGGAGAGSGGRGLMGQIIPIYGFGIFLYILYILFKLSRGKSTAEDRKCSTATPGNTHRKITNFELVQLQEKLKETEEAMEKLINRVGPNGERAQTVTSDQEKRLLHQLREITRVMKEGKFIDRSTPEKEAEEAPYMEDWEGYPEETYPIYDLSDCIKHRQETILVDYPDSKEPSAEEIAERMGMLEEEESDRVGWAMPTEPRAQEDNSVTSCDPEPEPCSCWSPEEEDPAVLAENAGFGANSYSEQEETTNEVWPYDLRVVSCICYFPEASHGERPQSSSTALRVFLWARPTGFTRKQQPALPAGTAEPAKDSLT", "length": 397, "header": "tr|A0AAA9SL08-1|F1MIY0_BOVIN Computationally mapped isoform of RIC3 acetylcholine receptor chaperone OS=Bos taurus OX=9913 GN=RIC3 PE=3 SV=1 CANONICAL=F1MIY0-1" }, "locus": { "chromosome": "15", "start_pos": 44432233, "end_pos": 44368165, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124833.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124833.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085971.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085971.1" } ] } }, { "isoform_ac": "A0AAA9TZI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZI8/entry", "sequence": { "sequence": "MAYSTVQRVALASGLVLAVSLLLPKAFLSRGKRQEPPPAPEGKLGRFPPMMHQQQAPSDGQTPGARFQRSHLAEAFAKSKGSGGGAGAGSGGRGLMGQIIPIYGFGIFLYILYILFKLSRGKSTAEDRKCSTATPGNTHRKISYPEETYPIYDLSDCIKHRQETILVDYPDSKEPSAEEIAERMGMLEEEESDRVGWAMPTEPRAQEDNSVTSCDPEPEPCSCWSPEEEDPAVLAENAGFGANSYSEQEETTNEVWPYDLRGEGSGISADKADPGGMLRKRHPQGLE", "length": 287, "header": "tr|A0AAA9TZI8-1|F1MIY0_BOVIN Computationally mapped isoform of RIC3 acetylcholine receptor chaperone OS=Bos taurus OX=9913 GN=RIC3 PE=3 SV=1 CANONICAL=F1MIY0-1" }, "locus": { "chromosome": "15", "start_pos": 44427864, "end_pos": 44368165, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126018.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126018.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103737.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103737.1" } ] } }, { "isoform_ac": "F1MIY0-1", "url": "https://www.uniprot.org/uniprotkb/F1MIY0/entry", "sequence": { "sequence": "MAYSTVQRVALASGLVLAVSLLLPKAFLSRGKRQEPPPAPEGKLGRFPPMMHQQQAPSDGQTPGARFQRSHLAEAFAKSKGSGGGAGAGSGGRGLMGQIIPIYGFGIFLYILYILFKLSRGKSTAEDRKCSTATPGNTHRKITNFELVQLQEKLKETEEAMEKLINRVGPNGESRAQTVTSDQEKRLLHQLREITRVMKEGKFIDRSTPEKEAEEAPYMEDWEGYPEETYPIYDLSDCIKHRQETILVDYPDSKEPSAEEIAERMGMLEEEESDRVGWAMPTEPRAQEDNSVTSCDPEPEPCSCWSPEEEDPAVLAENAGFGANSYSEQEETTNEVWPYDLRGEGSGISADKADPGGMLRKRHPQGLE", "length": 368, "header": "tr|F1MIY0-1|F1MIY0_BOVIN Isoform 1 of RIC3 acetylcholine receptor chaperone OS=Bos taurus OX=9913 GN=RIC3 PE=3 SV=3 CANONICAL=F1MIY0-1" }, "locus": { "chromosome": "15", "start_pos": 44427864, "end_pos": 44368165, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006392.8", "url": "https://www.ensembl.org/id/ENSBTAT00000006392.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006392.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006392.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 134, "start_aa": "Thr", "end_pos": 134, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr134", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1MIY0", "url": "https://www.uniprot.org/uniprotkb/F1MIY0" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "F1MIY0", "url": "https://www.uniprot.org/uniprotkb/F1MIY0" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1MIY0", "url": "https://www.uniprot.org/uniprotkb/F1MIY0" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "F1MIY0", "url": "https://www.uniprot.org/uniprotkb/F1MIY0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of protein localization to cell surface", "id": "GO:2000010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000010", "evidence": [ { "database": "UniProtKB", "id": "F1MIY0", "url": "https://www.uniprot.org/uniprotkb/F1MIY0" } ], "pmid": "" }, { "name": "synaptic transmission, cholinergic", "id": "GO:0007271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007271", "evidence": [ { "database": "UniProtKB", "id": "F1MIY0", "url": "https://www.uniprot.org/uniprotkb/F1MIY0" } ], "pmid": "" }, { "name": "protein localization to cell surface", "id": "GO:0034394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034394", "evidence": [ { "database": "UniProtKB", "id": "F1MIY0", "url": "https://www.uniprot.org/uniprotkb/F1MIY0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein folding chaperone", "id": "GO:0044183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044183", "evidence": [ { "database": "UniProtKB", "id": "F1MIY0", "url": "https://www.uniprot.org/uniprotkb/F1MIY0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MIY0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 368, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MIY0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MIY0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MIY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIY0" }, { "id": "PF15361", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15361" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Resistance to inhibitors of cholinesterase protein 3 N-terminal", "eco_id": "ECO_0000259", "start_pos": 15, "end_pos": 166, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 134 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "F1MHJ3", "url": "https://www.uniprot.org/uniprotkb/F1MHJ3#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MHJ3", "url": "https://www.uniprot.org/uniprotkb/F1MHJ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF268", "url": "https://www.uniprot.org/uniprotkb/F1MHJ3", "locus": { "chromosome": "17", "start_pos": 44230138, "end_pos": 44194889, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040336", "url": "https://www.ensembl.org/id/ENSBTAG00000040336" } ] } } ], "crossref": [ { "id": "F1MHJ3", "url": "https://alphafold.ebi.ac.uk/entry/F1MHJ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039316", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039316", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506621", "url": "https://www.ncbi.nlm.nih.gov/gene/506621", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050589", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050589", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506621", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506621", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MHJ3", "url": "https://www.orthodb.org/?gene=F1MHJ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24404:SF41", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24404:SF41", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001077115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077115", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RYI2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYI2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLB8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLB8-1", 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"MATRVRTAAIWVPPLQERDSSCNVSRKLQSEKSILDQGTPDQKPLSGGPWQRPRRPGVLEWLLISQDQPKAKKSWGPLSFMDVFVDFTWEEWQLLDSAQKHLYRSVMLENFRNLVSLGYQYTKPSIIFQLEQEELWMMHSPSQGHSDEVWEIDGCVEWHQENQGKLGSMAEGYPCTAFGKLCLITANNASSRQRLHKCVTNGKSLKCNIGLSNNYAGKNPNDIHALRESSVLSKHEQAVIGIKYCESDESGKTANRKPLLICQQMHMGGKSFECNSCGKAFSSKSNFVVHQETHEEAKPYKCDGCGKDSSNKSYLVAHQRTHKGEQLHECSDLKTFSFNSQLVLHQRIHTQENPYECCECGKVFTRRDQLVSHQRTHSGLKPYGCHECGKAFGLKSQLIIHQRIHTGEKPYECSDCRKAFNTKSNLMVHQRTHTGEKPYSCSECGKAFTFKSQLIVHQGAHSGVKPYGCNQCGKAFSLKSQLIVHQRSHTGVKPYGCNECGKAFRSKSYLVIHQRTHTGEKLHECCECGRAFSFNSQLVIHQRIHTGENPYECSECGKAFSRKYQLISHQRTHAGEKPYECSDCGKTFGLKSQLVIHQRTHTGEKPYECSECQKAFNTKSNLIVHQRTHTGEKPYGCSECGKSFTFKSQLIVHQGAHTGIKPYGCNQCGKAFSLKSQLIVHQRSHTGLKPYGCIECGKAFRSKSYLIIHTRTHTGEKPHECSECGKSFSFNSQLIVHQRIHTGENPYECSDCGKAFNRKDQLISHQRTHAGEKPYGCSECGKAFSSKSYLIIHMRTHSGEKPYECHKCGKAFIWKSLLIVHERTHAGENPYKCSQCEKSFSGKLRLLVHQRMHMREKPYECNECEKAFIRKSQLIVHQRTHSGEKPYECSECRKTFSQKSILSAHQRTHTGEKPCKCTECGKAFCWKSQLIMHQRTHADEKHIGELNIRNFFSKVNSPEFLENSYRGETL", "length": 970, "header": "tr|F1MHJ3-1|F1MHJ3_BOVIN Isoform 1 of Zinc finger protein 268 OS=Bos taurus OX=9913 GN=ZNF268 PE=3 SV=4 CANONICAL=F1MHJ3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYI2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYI2/entry", "sequence": { "sequence": "MATRVRTAAIWVPPLQERDSSCNVSRKLQSEKSILDQGTPDQKPLSGGPWQRPRRPGVLEWLLISQDQPKAKKSWTKSGKLMVVWNGIRKIKASWEVWQKAIPVLLLENCVLLLQIMLLQDRDFINVSQMGRV", "length": 133, "header": "tr|A0AAA9RYI2-1|F1MHJ3_BOVIN Computationally mapped isoform of Zinc finger protein 268 OS=Bos taurus OX=9913 GN=ZNF268 PE=3 SV=1 CANONICAL=F1MHJ3-1" }, "locus": { "chromosome": "17", "start_pos": 44224683, "end_pos": 44195552, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097475.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097475.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077667.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077667.1" } ] } }, { "isoform_ac": "A0AAA9TLB8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLB8/entry", "sequence": { "sequence": "MATRVRTAAIWVPPLQERDSSCNVSRKLQSEKSILDQGTPDQKPLSGGPWQRPRRPGVLEWLLISQDQPKAKKSWVSPCLFISTSFLYSFLIFFLVGKGMEVLRWAFLIIVYNFPFTGYQYTKPSIIFQLEQEELWMMHSPSQGHSGE", "length": 148, "header": "tr|A0AAA9TLB8-1|F1MHJ3_BOVIN Computationally mapped isoform of Zinc finger protein 268 OS=Bos taurus OX=9913 GN=ZNF268 PE=3 SV=1 CANONICAL=F1MHJ3-1" }, "locus": { "chromosome": "17", "start_pos": 44220896, "end_pos": 44195552, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108282.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108282.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099229.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099229.1" } ] } }, { "isoform_ac": "F1MHJ3-1", "url": "https://www.uniprot.org/uniprotkb/F1MHJ3/entry", "sequence": { "sequence": 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH25/entry#names_and_taxonomy" } ] }, { "name": "archaemetzincin-2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005221412", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221412" } ] } ], "function": [ { "annotation": "Probable zinc metalloprotease.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RYP7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYP7#function" }, { "database": "UniProtKB", "id": "ARBA00024316", "url": "https://www.uniprot.org/uniprotkb/ARBA00024316#function" }, { "database": "UniProtKB", "id": "A0AAA9SZR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZR1#function" }, { "database": "UniProtKB", "id": "F1MH25", "url": "https://www.uniprot.org/uniprotkb/F1MH25#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MH25", "url": "https://www.uniprot.org/uniprotkb/F1MH25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AMZ2", "url": "https://www.uniprot.org/uniprotkb/F1MH25", "locus": { "chromosome": "19", "start_pos": 61889088, "end_pos": 61896148, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009345", "url": "https://www.ensembl.org/id/ENSBTAG00000009345" } ] } } ], "crossref": [ { "id": "F1MH25", "url": "https://alphafold.ebi.ac.uk/entry/F1MH25", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009345", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009345", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11375", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11375", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515126", "url": 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"PTHR32205:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32205:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07998", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07998", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005221412", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221412", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RYP7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZR1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZR1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZR1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH25", "url": "https://www.uniprot.org/uniprotkb/F1MH25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH25-1", "url": "https://www.uniprot.org/uniprotkb/F1MH25-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQTVGHSEHTLKTALISKNPELVKQYEQLDPGEQRLLNEAFRPRSDLFGPITLHSPSDWIISHPEAPQDFEQFFSNLHRKSPSPGKQTIYIQCIGLLGNTRSISEEYLKWLKGYCEAFFYGLTVKLLEPIPVSATRCSFRINDSTLNLQIHAGQILTFLKKKKPEDAFCVVGVTMIDLYPRESWNFVFGQASLTEGVGIFSFARYGTDFYSSHYKGKLKKLERKSSSDYSVFNDYYLPEATSVLLLRSCKTLTHEIGHIFGLRHCQWLACLMQGSNHLEEADRRPLDLCPICLRKLQSAVGFRLRDRYKALVRWIDAESTDTPRVTPKHSREELVTLPKPVEAFKEWKEWVTRCLAVLQK", "length": 360, "header": "tr|F1MH25-1|F1MH25_BOVIN Isoform 1 of Archaemetzincin-2 OS=Bos taurus OX=9913 GN=AMZ2 PE=3 SV=3 CANONICAL=F1MH25-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYP7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYP7/entry", "sequence": { "sequence": 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"uniprot_canonical_ac": "Q400C7-1", "protein_name": "Archaemetzincin-2", "gene_name": "Amz2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQVLRHSEHTLKTALLSKNPDLVSQYEKLDAGEQRLMNEAFQPRNNLFEPITLHSQSDWISSHPEAPQDFEQFFSDRYRKAPCPKKHIIYIQPIGFLGNTRVISEEYIKWLKGYCEAFFYGLKVKFLEPVSVSATKCSFRVNENTQNLQIHTGHILAFLKRNKPEDAFCIVGITMIDLYPRDSWNFVFGQASLSSGVGIFSFARYGKDFYTSKYEGSVKVPQRTVSSDYSIFDNYYIPEITSVLLLRSCKTLTHEIGHILGLRHCQWLACLMQGSNHLEESDRRPLNVCPICLRKLQSAIGFNIVERYKALVKWIDDESCGESGATPKSSSEHVYLPKPVEAFKDWREWILRCIAVLEK", "length": 359 }, "evidence": [ { "id": "F1MH25", "url": "https://omabrowser.org/oma/group/F1MH25/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q400C8-1", "protein_name": "Archaemetzincin-2", "gene_name": "Amz2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQVLRHSEHTLKTALLSKNPVLVSQYEKLDAGEQRLMNEAFQPRSNLFEPITVHSQSDWISSHPEAPQDFEQFFSDRYRKAPCPKKHIIYIQSIGSLGNTRVISEEYIKWLKGYCEAFFYGLKVKFLEPVSVSETKCSFRVNEHTQNLQIHTGHILAFLKKNKPEDAFCIVGITMIDLYPRDSWNFVFGQASLSSGVGIFSFARYGKDFYTSKYEGNVTSLQLTSPTDYSIFDNYYIPEITSVLLLRSCKTLTHEIGHILGLRHCQWLACLMQGSNHLEESDRRPLNVCPICLRKLQSAIGFNIVERYRALVKWIDDESCNESGATPKSSSEHAHLPKPVEAFKDWREWLMRCIALLEK", "length": 359 }, "evidence": [ { "id": "F1MH25", "url": "https://omabrowser.org/oma/group/F1MH25/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86W34-4", "protein_name": "Archaemetzincin-2", "gene_name": "AMZ2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQIIRHSEQTLKTALISKNPVLVSQYEKLNAGEQRLMNEAFQPASDLFGPITLHSPSDWITSHPEAPQDFEQFFSDPYRKTPSPNKRSIYIQSIGSLGNTRIISEEYIKWLTGYCKAYFYGLRVKLLEPVPVSVTRCSFRVNENTHNLQIHAGDILKFLKKKKPEDAFCVVGITMIDLYPRDSWNFVFGQASLTDGVGIFSFARYGSDFYSMHYKGKVKKLKKTSSSDYSIFDNYYIPEITSVLLLRSCKTLTHEIGHIFGLRHCQWLACLMQGSNHLEEADRRPLNLCPICLHKLQCAVGFSIVERYKALVRWIDDESSDTPGATPEHSHEDNGNLPKPVEAFKEWKEWIIKCLAVLQK", "length": 360 }, "evidence": [ { "id": "F1MH25", "url": "https://omabrowser.org/oma/group/F1MH25/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1MH25", "url": "https://www.uniprot.org/uniprotkb/F1MH25" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metallopeptidase activity", "id": "GO:0008237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008237", "evidence": [ { "database": "UniProtKB", "id": "F1MH25", "url": "https://www.uniprot.org/uniprotkb/F1MH25" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MH25", "url": "https://www.uniprot.org/uniprotkb/F1MH25" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MH25-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 360, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MH25-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MH25" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MC45-1", "uniprot_ac": "F1MC45", "uniprot_id": "F1MC45_BOVIN", "mass": { "chemical_mass": 106460.0, "monoisotopic_mass": 106460.0 }, "refseq": {}, "gene_names": [ { "name": "LOC100336868", "type": "recommended", "evidence": [ { "id": "F1MC45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC45" } ] } ], "protein_names": [ { "name": "Sushi domain-containing protein", "type": "recommended", "evidence": [ { "id": "F1MC45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC45/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MC45", "url": "https://www.uniprot.org/uniprotkb/F1MC45" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100336868", "url": "https://www.uniprot.org/uniprotkb/F1MC45", "locus": {} } ], "crossref": [ { "id": "F1MC45", "url": "https://alphafold.ebi.ac.uk/entry/F1MC45", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039995", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039995", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000040409", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040409", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00033", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00033", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45785", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45785", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45785:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45785:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00084", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00084", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-977606", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977606", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RYW4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T839", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T839", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T839-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T839-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFN5", "url": "https://www.uniprot.org/uniprotkb/E1BFN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BFN5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFN5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC45", "url": "https://www.uniprot.org/uniprotkb/F1MC45", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC45-1", "url": "https://www.uniprot.org/uniprotkb/F1MC45-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MW79", "url": "https://www.uniprot.org/uniprotkb/F1MW79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MW79-1", "url": "https://www.uniprot.org/uniprotkb/F1MW79-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X7F3", "url": "https://www.uniprot.org/uniprotkb/G3X7F3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3X7F3-1", "url": "https://www.uniprot.org/uniprotkb/G3X7F3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "DTFRIIFRKKWKYKTLFLLLLFQGKPCNYPVIKHGRLYYSYRGYFPAHVNQQFVYNCDHYFVPPSQRSWDHLTCTAEGWSPEEPCLRQCIFNYLENGHTPHPEEKYLQGETVRVRCYEGYSLQNDQNTMTCTESGWSPPPRCIRVKTCSKSNIRIENGFLSKSTFTYPLNKQTEYKCKPGYVTADGKTSGLITCLQNGWSAQPVCIKSCDRPVFEKARVKSDGMWFRLNDRLDYECVDGYENRDGRTTGSIVCSQDGWSDKAACYERECSIPEMDPYLNAYPRKEIYKVGDVLKFSCSQGRIMVGADSVQCYHFGWSPKLPKCKARKVKSCAPPPQLLNGKGKKLHKEEYAHNEVVEYACNPRFLMKGSHKIQCVDGEWTALPVCIEEKRTCGDIPDLDHADIKPSVPPYHHGDSVEFSCREAFTMIGPRFITCISGEWTQPPQCIATDELRKCKWSTLFPPEGKPARRIEYDHSTNKSYQCRGKSEHKHSICINGKWDPKVDCKEEAQKQPCPPPPQIPNARDMTTTVKYQDGEKISILCKENYLIQDAEEIVCKDGRWQSIPRCTGKKIGCSQPPQIDHGTINSSSCAEERREIHEQRLYAHGTKLSYACEEGFEISENDVIICHMGKWSSPPQCAGLPPYILNGVVSHKKDSYQYGEEVTYKCDEGFGTDGPASVRCLGREWSCPQNCISTNCVNLPTFDDAVLIDQEKDFYRSGEQVAFKCLSYYQLDGSNTIQCIKSKWIGRTAYRDVSWVNPPQVENAIIHNQKSRYHSGEKAHYECIGNYDLFGEIHVVCLNGTWTKPPQCKGKCGPPPTIENGDITSLLKSVYPPGVIVEYRCQAYYELRGNRNVVCQNGEWSEPPKCLEACAISEETMKNHHIQLRWKHDTKLYSKTEDNIVFMCQHSYRRMTPQHTFRTTCQEGKVMYP", "length": 929, "header": "tr|F1MC45-1|F1MC45_BOVIN Isoform 1 of Sushi domain-containing protein OS=Bos taurus OX=9913 GN=LOC100336868 PE=4 SV=4 CANONICAL=F1MC45-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYW4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYW4/entry", "sequence": { "sequence": "MLLLINVLLTSWFYTAHGQGKPCNYPVIKHGRLYYSYRGYFPAHVNQQFVYNCDHYFVPPSQRSWDHLTCTAEGWSPEEPCLRQCIFNYLENGHTPHPEEKYLQGETVRVRCYEGYSLQNDQNTMTCTESGWSPPPRCIRVRKCGPPPPIDNGEITSLLQSVYPPGMIVEYRCQAYYELQGNRKVVCRNGKWSQPPKCLEACLISEETMRKHHIELRWKYDKKLYSKTEDTIEFMCQYGYRQLTPKHTFRTTCREGKVVYPQCG", "length": 264, "header": "tr|A0AAA9RYW4-1|F1MC45_BOVIN Computationally mapped isoform of Sushi domain-containing protein OS=Bos taurus OX=9913 GN=LOC100336868 PE=4 SV=2 CANONICAL=F1MC45-1" }, "locus": { "chromosome": "16", "start_pos": 5723824, "end_pos": 5658299, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116142.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116142.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076334.2", "url": "https://www.ensembl.org/id/ENSBTAP00000076334.2" } ] } }, { "isoform_ac": "A0AAA9T839-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T839/entry", "sequence": { "sequence": "QNKYFSMSAEFHNKTLFLLLLFQGKPCNYPVIKHGRLYYSYRGYFPAHVNQQFVYNCDHYFVPPSQRSWDHLTCTAEGWSPEEPCLRQCIFNYLENGHTPHPEEKYLQGETVRVRCYEGYSLQNDQNTMTCTESGWSPPPRCIRVKTCSKSNIRIENGFLSKSTFTYPLNKQTEYKCKPGYVTADGKTSGLITCLQNGWSAQPVCIKRECSIPEMDPYLNAYPRKEIYKVGDVLKFSCSQGRIMVGADSVQCYHFGWSPKLPKCKARKVKSCAPPPQLLNGKGKKLHKEEYAHNEVVEYACNPRFLMKGSHKIQCVDGEWTALPVCIEEKRTCGDIPDLDHADIKPSVPPYHHGDSVEFSCREAFTMIGPRFITCISGEWTQPPQCIATDELRKCKWSTLFPPEGKPARRIEYDHSTNKSYQCRGKSEHKHSICINGKWDPKVDCKEAQKQPCPPPPQIPNARDMTTTVKYQDGEKISILCKENYLIQDAEEIVCKDGRWQSIPRCTGKKIGCSQPPQIDHGTINSSSCAEERREIHEQRLYAHGTKLSYACEEGFEISENDVIICHMGKWSSPPQCAGLPPYILNGVVSHKKDSYQYGEEVTYKCDEGFGTDGPASVRCLGREWSCPQNCISTNCVNLPTFDDAVLIDQEKDFYRSGEQVAFKCLSYYQLDGSNTIQCIKSKWIGRTAYRDVSWVNPPQVENAIIHNQKSRYHSGEKAHYECIGNYDLFGEIHVVCLNGTWTKPPQCKGKCGPPPTIENGDITSLLKSVYPPGVIVEYRCQAYYELRGNRNVVCQNGEWSEPPKCLEACAISEETMKNHHIQLRWKHDTKLYSKTEDNIVFMCQHSYRRMTPQHTFRTTCQEGKVMYP", "length": 869, "header": "tr|A0AAA9T839-1|F1MC45_BOVIN Computationally mapped isoform of Sushi domain-containing protein OS=Bos taurus OX=9913 GN=LOC100336868 PE=4 SV=2 CANONICAL=F1MC45-1" }, "locus": { "chromosome": "16", "start_pos": 5723597, "end_pos": 5627224, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088937.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088937.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092972.2", "url": "https://www.ensembl.org/id/ENSBTAP00000092972.2" } ] } }, { "isoform_ac": "E1BFN5-1", "url": "https://www.uniprot.org/uniprotkb/E1BFN5/entry", "sequence": { "sequence": "DTFRIIFRKKWKYKTLFLLLLFQGKPCNYPVIKHGRLYYSYRGYFPAHVNQQFVYNCDHYFVPPSQRSWDHLTCTAEGWSPEEPCLRQCIFNYLENGHTPHPEEKYLQGETVRVRCYEGYSLQNDQNTMTCTESGWSPPPRCIRVKTCSKSNIRIENGFLSKSTFTYPLNKQTEYKCKPGYVTADGKTSGLITCLQNGWSAQPVCIKSCDRPVFEKARVKSDGMWFRLNDRLDYECVDGYENRDGRTTGSIVCSQDGWSDKAACYERECSIPEMDPYLNAYPRKEIYKVGDVLKFSCSQGRIMVGADSVQCYHFGWSPKLPKCKARKVKSCAPPPQLLNGKGKKLHKEEYAHNEVVEYACNPRFLMKGSHKIQCVDGEWTALPVCIEEKRTCGDIPDLDHADIKPSVPPYHHGDSVEFSCREAFTMIGPRFITCISGEWTQPPQCIEAQKQPCPPPPQIPNARDMTTTVKYQDGEKISILCKENYLIQDAEEIVCKDGRWQSIPRCTGKKIGCSQPPQIDHGTINSSSCAEERREIHEQRLYAHGTKLSYACEEGFEISENDVIICHMGKWSSPPQCAGLPPYILNGVVSHKKDSYQYGEEVTYKCDEGFGTDGPASVRCLGREWSCPQNCISTNCVNLPTFDDAVLIDQEKDFYRSGEQVAFKCLSYYQLDGSNTIQCIKSKWIGRTAYRDVSWVNPPQVENAIIHNQKSRYHSGEKAHYECIGNYDLFGEIHVVCLNGTWTKPPQCKGKCGPPPTIENGDITSLLKSVYPPGVIVEYRCQAYYELRGNRNVVCQNGEWSEPPKCLEACAISEETMKNHHIQLRWKHDTKLYSKTEDNIVFMCQHSYRRMTPQHTFRTTCQEGKVMYP", "length": 869, "header": "tr|E1BFN5-1|F1MC45_BOVIN Computationally mapped isoform of Sushi domain-containing protein OS=Bos taurus OX=9913 GN=LOC100336868 PE=4 SV=4 CANONICAL=F1MC45-1" }, "locus": { "chromosome": "16", "start_pos": 5723201, "end_pos": 5627224, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031527.6", "url": "https://www.ensembl.org/id/ENSBTAT00000031527.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031480.6", "url": "https://www.ensembl.org/id/ENSBTAP00000031480.6" } ] } }, { "isoform_ac": "F1MC45-1", "url": "https://www.uniprot.org/uniprotkb/F1MC45/entry", "sequence": { "sequence": "DTFRIIFRKKWKYKTLFLLLLFQGKPCNYPVIKHGRLYYSYRGYFPAHVNQQFVYNCDHYFVPPSQRSWDHLTCTAEGWSPEEPCLRQCIFNYLENGHTPHPEEKYLQGETVRVRCYEGYSLQNDQNTMTCTESGWSPPPRCIRVKTCSKSNIRIENGFLSKSTFTYPLNKQTEYKCKPGYVTADGKTSGLITCLQNGWSAQPVCIKSCDRPVFEKARVKSDGMWFRLNDRLDYECVDGYENRDGRTTGSIVCSQDGWSDKAACYERECSIPEMDPYLNAYPRKEIYKVGDVLKFSCSQGRIMVGADSVQCYHFGWSPKLPKCKARKVKSCAPPPQLLNGKGKKLHKEEYAHNEVVEYACNPRFLMKGSHKIQCVDGEWTALPVCIEEKRTCGDIPDLDHADIKPSVPPYHHGDSVEFSCREAFTMIGPRFITCISGEWTQPPQCIATDELRKCKWSTLFPPEGKPARRIEYDHSTNKSYQCRGKSEHKHSICINGKWDPKVDCKEEAQKQPCPPPPQIPNARDMTTTVKYQDGEKISILCKENYLIQDAEEIVCKDGRWQSIPRCTGKKIGCSQPPQIDHGTINSSSCAEERREIHEQRLYAHGTKLSYACEEGFEISENDVIICHMGKWSSPPQCAGLPPYILNGVVSHKKDSYQYGEEVTYKCDEGFGTDGPASVRCLGREWSCPQNCISTNCVNLPTFDDAVLIDQEKDFYRSGEQVAFKCLSYYQLDGSNTIQCIKSKWIGRTAYRDVSWVNPPQVENAIIHNQKSRYHSGEKAHYECIGNYDLFGEIHVVCLNGTWTKPPQCKGKCGPPPTIENGDITSLLKSVYPPGVIVEYRCQAYYELRGNRNVVCQNGEWSEPPKCLEACAISEETMKNHHIQLRWKHDTKLYSKTEDNIVFMCQHSYRRMTPQHTFRTTCQEGKVMYP", "length": 929, "header": "tr|F1MC45-1|F1MC45_BOVIN Isoform 1 of Sushi domain-containing protein OS=Bos taurus OX=9913 GN=LOC100336868 PE=4 SV=4 CANONICAL=F1MC45-1" }, "locus": { "chromosome": "16", "start_pos": 5723201, "end_pos": 5627224, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029340.7", "url": "https://www.ensembl.org/id/ENSBTAT00000029340.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029340.7", "url": "https://www.ensembl.org/id/ENSBTAP00000029340.7" } ] } }, { "isoform_ac": "F1MW79-1", "url": "https://www.uniprot.org/uniprotkb/F1MW79/entry", "sequence": { "sequence": "DTFRIIFRKKWKYKTLFLLLLFQGKPCNYPVIKHGRLYYSYRGYFPAHVNQQFVYNCDHYFVPPSQRSWDHLTCTAEGWSPEEPCLRQCIFNYLENGHTPHPEEKYLQGETVRVRCYEGYSLQNDQNTMTCTESGWSPPPRCIRVKTCSKSNIRIENGFLSKSTFTYPLNKQTEYKCKPGYVTADGKTSGLITCLQNGWSAQPVCIKSCDRPVFEKARVKSDGMWFRLNDRLDYECVDGYENRDGRTTGSIVCSQDGWSDKAACYERECSIPEMDPYLNAYPRKEIYKVGDVLKFSCSQGRIMVGADSVQCYHFGWSPKLPKCKARKVKSCAPPPQLLNGKGKKLHKEEYAHNEVVEYACNPRFLMKGSHKIQCVDGEWTALPVCIEEKRTCGDIPDLDHADIKPSVPPYHHGDSVEFSCREAFTMIGPRFITCISGEWTQPPQCIATDELRKCKWSTLFPPEGKPARRIEYDHSTNKSYQCRGKSEHKHSICINGKWDPKVDCKEGNLLKIGCSQPPQIDHGTINSSSCAEERREIHEQRLYAHGTKLSYACEEGFEISENDVIICHMGKWSSPPQCAGLPPYILNGVVSHKKDSYQYGEEVTYKCDEGFGTDGPASVRCLGREWSCPQNCISTNCVNLPTFDDAVLIDQEKDFYRSGEQVAFKCLSYYQLDGSNTIQCIKSKWIGRTAYRDVSWVNPPQVENAIIHNQKSRYHSGEKAHYECIGNYDLFGEIHVVCLNGTWTKPPQCKGKCGPPPTIENGDITSLLKSVYPPGVIVEYRCQAYYELRGNRNVVCQNGEWSEPPKCLEACAISEETMKNHHIQLRWKHDTKLYSKTEDNIVFMCQHSYRRMTPQHTFRTTCQEGKVMYP", "length": 870, "header": "tr|F1MW79-1|F1MC45_BOVIN Computationally mapped isoform of Sushi domain-containing protein OS=Bos taurus OX=9913 GN=LOC100336868 PE=4 SV=4 CANONICAL=F1MC45-1" }, "locus": { "chromosome": "16", "start_pos": 5723201, "end_pos": 5627224, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055302.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055302.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047973.4", "url": "https://www.ensembl.org/id/ENSBTAP00000047973.4" } ] } }, { "isoform_ac": "G3X7F3-1", "url": "https://www.uniprot.org/uniprotkb/G3X7F3/entry", "sequence": { "sequence": "MLLLINVLLTSWFYTAHGQGKPCNYPVIKHGRLYYSYRGYFPAHVNQQFVYNCDHYFVPPSQRSWDHLTCTAEGWSPEEPCLRQCIFNYLENGHTPHPEEKYLQGETVRVRCYEGYSLQNDQNTMTCTESGWSPPPRCIRVKTCSKSNIRIENGFLSKSTFTYPLNKQTEYKCKPGYVTADGKTSGLITCLQNGWSAQPVCIKSCDRPVFEKARVKSDGMWFRLNDRLDYECVDGYENRDGRTTGSIVCSQDGWSDKAACYERECSIPEMDPYLNAYPRKEIYKVGDVLKFSCSQGRIMVGADSVQCYHFGWSPKLPKCKARKVKSCAPPPQLLNGKGKKLHKEEYAHNEVVEYACNPRFLMKGSHKIQCVDGEWTALPVCIEEKRTCGDIPDLDHADIKPSVPPYHHGDSVEFSCREAFTMIGPRFITCISGEWTQPPQCIATDELRKCKWSTLFPPEGKPARRIEYDHSTNKSYQCRGKSEHKHSICINGKWDPKVDCKEEAQKQPCPPPPQIPNARDMTTTVKYQDGEKISILCKENYLIQDAEEIVCKDGRWQSIPRCTGKKIGCSQPPQIDHGTINSSSCAEERREIHEQRLYAHGTKLSYACEEGFEISENDVIICHMGKWSSPPQCAGLPPYILNGVVSHKKDSYQYGEEVTYKCDEGFGTDGPASVRCLGREWSCPQNCISTNCVNLPTFDDAVLIDQEKDFYRSGEQVAFKCLSYYQLDGSNTIQCIKSKWIGRTAYRDVSWVNPPQVENAIIHNQKSRYHSGEKAHYECIGNYDLFGEIHVVCLNGTWTKPPQCKGKCGPPPTIENGDITSLLKSVYPPGVIVEYRCQAYYELRGNRNVVCQNGEWSEPPKCLEACAISEETMKNHHIQLRWKHDTKLYSKTEDNIVFMCQHSYRRMTPQHTFRTTCQEGKVMYP", "length": 925, "header": "tr|G3X7F3-1|F1MC45_BOVIN Computationally mapped isoform of Sushi domain-containing protein OS=Bos taurus OX=9913 GN=LOC100336868 PE=4 SV=3 CANONICAL=F1MC45-1" }, "locus": { "chromosome": "16", "start_pos": 5723824, "end_pos": 5627224, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025846.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025846.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025846.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025846.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-977606", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-977606", "resource": "Reactome", "description": "Regulation of Complement cascade" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MC45", "url": "https://www.uniprot.org/uniprotkb/F1MC45" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1MC45", "url": "https://www.uniprot.org/uniprotkb/F1MC45" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "complement component C3b binding", "id": "GO:0001851", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001851", "evidence": [ { "database": "UniProtKB", "id": "F1MC45", "url": "https://www.uniprot.org/uniprotkb/F1MC45" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "complement activation", "id": "GO:0006956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006956", "evidence": [ { "database": "UniProtKB", "id": "F1MC45", "url": "https://www.uniprot.org/uniprotkb/F1MC45" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 477, "end_pos": 479, "annotation": "n_glycosylation_sequon" }, { "start_pos": 585, "end_pos": 587, "annotation": "n_glycosylation_sequon" }, { "start_pos": 799, "end_pos": 801, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MC45-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 929, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MC45-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MC45" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MC45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC45" }, { "id": "PS50923", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50923" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sushi", "eco_id": "ECO_0000259", "start_pos": 87, "end_pos": 144, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 477, "end_pos": 479 }, { "start_pos": 585, "end_pos": 587 }, { "start_pos": 799, "end_pos": 801 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MF28-1", "uniprot_ac": "F1MF28", "uniprot_id": "F1MF28_BOVIN", "mass": { "chemical_mass": 56416.0, "monoisotopic_mass": 56416.0 }, "refseq": {}, "gene_names": [ { "name": "NTN5", "type": "recommended", "evidence": [ { "id": "F1MF28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF28" } ] } ], "protein_names": [ { "name": "Netrin 5", "type": "synonym", "evidence": [ { "id": "F1MF28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF28/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MF28", "url": "https://www.uniprot.org/uniprotkb/F1MF28" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NTN5", "url": "https://www.uniprot.org/uniprotkb/F1MF28", "locus": { "chromosome": "18", "start_pos": 55293919, "end_pos": 55299756, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044132", "url": "https://www.ensembl.org/id/ENSBTAG00000044132" } ] } } ], "crossref": [ { "id": "F1MF28", "url": "https://alphafold.ebi.ac.uk/entry/F1MF28", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044132", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044132", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00055", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00055", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd03579", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03579", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "785970", "url": "https://www.ncbi.nlm.nih.gov/gene/785970", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001134", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001134", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018933", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018933", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050440", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050440", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MF28", "url": "https://www.orthodb.org/?gene=F1MF28", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10574", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10574", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10574:SF262", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10574:SF262", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00053", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00053", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01759", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01759", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24973", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24973", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S037", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S037", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S037-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S037-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF28", "url": "https://www.uniprot.org/uniprotkb/F1MF28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF28-1", "url": "https://www.uniprot.org/uniprotkb/F1MF28-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVTFALWLLLSQASADPCYHPGGRPRFCLPPVTQLAGMAASCPQACGPSPGVDLGPRAPCNGSLTLGLGGPFLLSSVSLRFCTPGPPALVLSAAWATGGPWRSLWRRPAWPGVLGGPERVIFRVPAGPKASVVASHLRLELGGRGGLAAAGVRGRCQCHGHAARCAARDRPPRCRCRHHTTGPGCESCQPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCERCRHHTAGRHCHYCQPGFWRDPGQPISSRKACRACQCHPIGATGGACNQTNGQCSCKLGVTGLTCNRCGPGYQQSRSPRMPCQRESWGRGPESQVGWEGDSQTSRGQDGNPRGDNHPCYNPSCLQLGPSVSKLLQYFGHQDTHEPSEVLPTGLRAPRAGAGVRGRGHDMAAAGRARAGRVQAGSTARAPWQPGRLGAPRRSDLRMLAPAPRQPLPAAGQNGWRPRSYTPRPRPPRPRAALEAALGPAAAAAAAGRARRGVPHLAAFDPEPRTQALEPKPRCLECHRRS", "length": 528, "header": "tr|F1MF28-1|F1MF28_BOVIN Isoform 1 of Netrin 5 OS=Bos taurus OX=9913 GN=NTN5 PE=4 SV=3 CANONICAL=F1MF28-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S037-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S037/entry", "sequence": { "sequence": "MPVTFALWLLLSQASADPCYHPGGRPRFCLPPVTQLAGMAASCPQACGPSPGVDLGPRAPCNGSLTLGLGGPFLLSSVSLRFCTPGPPALVLSAAWATGGPWRSLWRRPAWPGVLGGPERVIFRVPAGPKASVVASHLRLELGGRGGLAAAGVRGRCQCHGHAARCAARDRPPRCRCRHHTTGPGCESCQPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCERCRHHTAGRHCHYCQPGFWRDPGQPISSRKACRACQCHPIGATGGACNQTNGQCSCKLGVTGLTCNRCGPGYQQSRSPRMPCQRILEATTTLATTPHAYSSVLHAQVLASEAADTTWQRLAVRVLAVYKQGAQPVRRGSQAAWVPRADLTCGCLRLRPASHYLLLGRTAGGPDPTRLVLDRHGLALPWRPRWARPLRRLQQEERAGGCRTLRPSTLSPEPRL", "length": 462, "header": "tr|A0AAA9S037-1|F1MF28_BOVIN Computationally mapped isoform of Netrin 5 OS=Bos taurus OX=9913 GN=NTN5 PE=4 SV=1 CANONICAL=F1MF28-1" }, "locus": { "chromosome": "18", "start_pos": 55299557, "end_pos": 55294413, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127192.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127192.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079214.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079214.1" } ] } }, { "isoform_ac": "F1MF28-1", "url": "https://www.uniprot.org/uniprotkb/F1MF28/entry", "sequence": { "sequence": "MPVTFALWLLLSQASADPCYHPGGRPRFCLPPVTQLAGMAASCPQACGPSPGVDLGPRAPCNGSLTLGLGGPFLLSSVSLRFCTPGPPALVLSAAWATGGPWRSLWRRPAWPGVLGGPERVIFRVPAGPKASVVASHLRLELGGRGGLAAAGVRGRCQCHGHAARCAARDRPPRCRCRHHTTGPGCESCQPSHRDWPWRPATPRHPHPCLPCSCNQHARRCRFNSELFRLSGGRSGGVCERCRHHTAGRHCHYCQPGFWRDPGQPISSRKACRACQCHPIGATGGACNQTNGQCSCKLGVTGLTCNRCGPGYQQSRSPRMPCQRESWGRGPESQVGWEGDSQTSRGQDGNPRGDNHPCYNPSCLQLGPSVSKLLQYFGHQDTHEPSEVLPTGLRAPRAGAGVRGRGHDMAAAGRARAGRVQAGSTARAPWQPGRLGAPRRSDLRMLAPAPRQPLPAAGQNGWRPRSYTPRPRPPRPRAALEAALGPAAAAAAAGRARRGVPHLAAFDPEPRTQALEPKPRCLECHRRS", "length": 528, "header": "tr|F1MF28-1|F1MF28_BOVIN Isoform 1 of Netrin 5 OS=Bos taurus OX=9913 GN=NTN5 PE=4 SV=3 CANONICAL=F1MF28-1" }, "locus": { "chromosome": "18", "start_pos": 55299557, "end_pos": 55294372, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061223.4", "url": 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"https://www.uniprot.org/uniprotkb/A0AAA9S1G0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHT2-1", "url": "https://www.uniprot.org/uniprotkb/F1MHT2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGMGGSLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT", "length": 416, "header": "tr|F1MHT2-1|F1MHT2_BOVIN Isoform 1 of 1-phosphatidylinositol-5-phosphate 4-kinase OS=Bos taurus OX=9913 GN=PIP4K2B PE=4 SV=2 CANONICAL=F1MHT2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S1G0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1G0/entry", "sequence": { "sequence": 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"https://www.uniprot.org/uniprotkb/A0AAA9TMS6/entry", "sequence": { "sequence": "MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGMGGSLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT", "length": 403, "header": "tr|A0AAA9TMS6-1|F1MHT2_BOVIN Computationally mapped isoform of 1-phosphatidylinositol-5-phosphate 4-kinase OS=Bos taurus OX=9913 GN=PIP4K2B PE=4 SV=1 CANONICAL=F1MHT2-1" }, "locus": { "chromosome": "19", "start_pos": 39381127, "end_pos": 39358844, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135968.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135968.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098535.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098535.1" } ] } }, { "isoform_ac": "F1MHT2-1", "url": "https://www.uniprot.org/uniprotkb/F1MHT2/entry", "sequence": { "sequence": "MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGMGGSLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT", "length": 416, "header": "tr|F1MHT2-1|F1MHT2_BOVIN Isoform 1 of 1-phosphatidylinositol-5-phosphate 4-kinase OS=Bos taurus OX=9913 GN=PIP4K2B PE=4 SV=2 CANONICAL=F1MHT2-1" }, "locus": { "chromosome": "19", "start_pos": 39381127, "end_pos": 39358844, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008517.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008517.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008517.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008517.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:539211", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539211", "resource": "KEGG Pathway" }, { "id": "R-BTA-1660499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660499", "resource": "Reactome", "description": "Synthesis of PIPs at the plasma membrane" }, { "id": "R-BTA-6811555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811555", "resource": "Reactome", "description": "PI5P Regulates TP53 Acetylation" }, { "id": "R-BTA-6811558", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811558", "resource": "Reactome", "description": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" }, { "id": "R-BTA-8847453", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8847453", "resource": "Reactome", "description": "Synthesis of PIPs in the nucleus" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480I421-1", "protein_name": "1-phosphatidylinositol-5-phosphate 4-kinase", "gene_name": "PIP4K2B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGMGGSLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT", "length": 416 }, "evidence": [ { "id": "F1MHT2", "url": "https://omabrowser.org/oma/group/F1MHT2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZGK7-1", "protein_name": "1-phosphatidylinositol-5-phosphate 4-kinase", "gene_name": "PIP4K2B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "TEAAGTAAGRGAASKTKTKKKHFVCQKVKLFRASEPLLSVLMWGANHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPLVFRNLRERFGIDDQDYQNSVTRSAPVNSDSQGRCGARFLTTYDRRFVIKAVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVSREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEDRAEDEECENDGLGGNPISSYGTPPDSPGNLLNYPRFFGPGEFDPSVDVYAMKSHDSAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT", "length": 411 }, "evidence": [ { "id": "F1MHT2", "url": "https://omabrowser.org/oma/group/F1MHT2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O88377-1", "protein_name": "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta", "gene_name": "Pip4k2b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLRVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEETEVEDRAEEEECENDGVGGGLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT", "length": 416 }, "evidence": [ { "id": "F1MHT2", "url": "https://omabrowser.org/oma/group/F1MHT2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P78356-1", "protein_name": "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta", "gene_name": "PIP4K2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT", "length": 416 }, "evidence": [ { "id": "F1MHT2", "url": "https://omabrowser.org/oma/group/F1MHT2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q80XI4-1", "protein_name": "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta", "gene_name": "Pip4k2b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEEEECENDGVGGSLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT", "length": 416 }, "evidence": [ { "id": "F1MHT2", "url": "https://omabrowser.org/oma/group/F1MHT2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "1-phosphatidylinositol-5-phosphate 4-kinase activity", "id": "GO:0016309", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016309", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" }, { "name": "1-phosphatidylinositol-4-phosphate 5-kinase activity", "id": "GO:0016308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016308", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" }, { "name": "autophagosome", "id": "GO:0005776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "phosphatidylinositol metabolic process", "id": "GO:0046488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046488", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" }, { "name": "negative regulation of insulin receptor signaling pathway", "id": "GO:0046627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046627", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" }, { "name": "positive regulation of autophagosome assembly", "id": "GO:2000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000786", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" }, { "name": "phosphatidylinositol phosphate biosynthetic process", "id": "GO:0046854", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046854", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" }, { "name": "autophagosome-lysosome fusion", "id": "GO:0061909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061909", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" }, { "name": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "id": "GO:1902635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902635", "evidence": [ { "database": "UniProtKB", "id": "F1MHT2", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" }, { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12280", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YLH5-1", "F1MHR4-1", "Q0P5F7-1", "F1MHT2-1" ], "evidence": [ { "id": "12280", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12280" } ] }, { "id": "55964", "name": "", "equation": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YLH5-1", "F1MHR4-1", "Q0P5F7-1", "F1MHT2-1" ], "evidence": [ { "id": "55964", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/55964" } ] }, { "id": "55992", "name": "", "equation": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6YLH5-1", "F1MHR4-1", "Q0P5F7-1", "F1MHT2-1" ], "evidence": [ { "id": "55992", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/55992" } ] }, { "id": "R-BTA-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-ALL-1806240" ], "output_participant_list": [], "enzyme_list": [ "F1MHR4-1", "Q0P5F7-1", "F1MHT2-1" ], "evidence": [ { "id": "R-BTA-1675776", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1675776" } ] }, { "id": "R-BTA-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-ALL-1806276" ], "output_participant_list": [], "enzyme_list": [ "F1MHR4-1", "F1MHT2-1" ], "evidence": [ { "id": "R-BTA-1676145", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1676145" } ] }, { "id": "R-BTA-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-ALL-6810408" ], "output_participant_list": [ "R-ALL-113582", "R-ALL-6810412" ], "enzyme_list": [ "F1MHR4-1", "Q0P5F7-1", "F1MHT2-1" ], "evidence": [ { "id": "R-BTA-6811522", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811522" } ] }, { "id": "R-BTA-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHR4-1", "Q5E9X2-1", "Q0P5F7-1", "F1MHT2-1" ], "evidence": [ { "id": "R-BTA-8877691", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8877691" } ] }, { "id": "R-BTA-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHR4-1", "Q0P5F7-1", "F1MHT2-1", "Q5BIN5-1" ], "evidence": [ { "id": "R-BTA-8877692", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8877692" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-113582", "participant_name": "ADP [nucleoplasm]", "crossref": [ { "id": "ZINC000012360703", "database": "ZINC", "url": "" }, { "id": "C00008", "database": "COMPOUND", "url": "" }, { "id": "456216", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1806240", "participant_name": "PI5P [plasma membrane]", "crossref": [ { "id": "57795", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1806276", "participant_name": "PI3P [plasma membrane]", "crossref": [ { "id": "58088", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-6810408", "participant_name": "PI5P [nucleoplasm]", "crossref": [ { "id": "57795", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-6810412", "participant_name": "PI(4,5)P2 [nucleoplasm]", "crossref": [ { "id": "58456", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6YLH5", "gene_name": "PIP4K2C", "activity": [ { "ec_number": "2.7.1.149", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAF6YLH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ] }, { "ec_number": "2.7.1.149", "activity": "", "evidence": [ { "id": "A0AAF6YLH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YLH5" } ] } ] }, { "uniprot_ac": "F1MHR4", "gene_name": "PIP4K2A", "activity": [ { "ec_number": "2.7.1.149", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MHR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHR4" } ] }, { "ec_number": "2.7.1.149", "activity": "", "evidence": [ { "id": "F1MHR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHR4" } ] } ] }, { "uniprot_ac": "F1MHT2", "gene_name": "PIP4K2B", "activity": [ { "ec_number": "2.7.1.149", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MHT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ] }, { "ec_number": "2.7.1.149", "activity": "", "evidence": [ { "id": "F1MHT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" } ] } ] }, { "uniprot_ac": "Q0P5F7", "gene_name": "PIP4K2C", "activity": [ { "ec_number": "2.7.1.149", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "Q0P5F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5F7" } ] }, { "ec_number": "2.7.1.149", "activity": "", "evidence": [ { "id": "Q0P5F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5F7" } ] } ] }, { "uniprot_ac": "Q5BIN5", "gene_name": "PIN1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q5BIN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIN5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q5BIN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5BIN5" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MHT2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 416, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MHT2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MHT2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MHT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHT2" }, { "id": "PS51455", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51455" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PIPK", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 415, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.149", "ec_name": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "2.7.1.149", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149" }, { "id": "2.7.1.149", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.149" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 4, "end_pos": 6 }, { "start_pos": 51, "end_pos": 53 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGN7-1", "uniprot_ac": "F1MGN7", "uniprot_id": "F1MGN7_BOVIN", "mass": { "chemical_mass": 43304.0, "monoisotopic_mass": 43304.0 }, "refseq": { "ac": "XP_024831274", "name": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831274" }, "gene_names": [ { "name": "B3GNT6", "type": "recommended", "evidence": [ { "id": "F1MGN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGN7" } ] }, { "name": "B3GNT6", "type": "synonym", "evidence": [ { "id": "XP_024831274", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831274" } ] } ], "protein_names": [ { "name": "Hexosyltransferase", "type": "recommended", "evidence": [ { "id": "F1MGN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGN7/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.-", "type": "synonym", "evidence": [ { "id": "F1MGN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGN7/entry#names_and_taxonomy" } ] }, { "name": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024831274", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831274" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MGN7", "url": "https://www.uniprot.org/uniprotkb/F1MGN7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "B3GNT6", "url": "https://www.uniprot.org/uniprotkb/F1MGN7", "locus": { "chromosome": "15", "start_pos": 56459264, "end_pos": 56447986, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000047129", "url": "https://www.ensembl.org/id/ENSBTAG00000047129" } ] } } ], "crossref": [ { "id": "F1MGN7", "url": "https://alphafold.ebi.ac.uk/entry/F1MGN7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000047129", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000047129", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540848", "url": "https://www.ncbi.nlm.nih.gov/gene/540848", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002659", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002659", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MWKALHN", "url": "https://omabrowser.org/oma/group/MWKALHN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGN7", "url": "https://www.orthodb.org/?gene=F1MGN7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11214", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11214", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11214:SF382", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11214:SF382", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01762", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01762", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-913709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024831274", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831274", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S2C3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2C3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2C3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2C3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGN7", "url": "https://www.uniprot.org/uniprotkb/F1MGN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGN7-1", "url": "https://www.uniprot.org/uniprotkb/F1MGN7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIQMAFPCRKFLKPKILTCLLAGLSFSILHHWFLRDPRFQQKQRSDGSLQVTHVAPAAMSPSSPGPPCVANASANATADFEKLPERIQDFLRYRHCRHFPLLWDAPAKCRGSRGPFLLLAVKSAPANFERRELIRRTWGQERSYGGRPVRRLFLLGTPAPEDAERAEQLAELAALEAREHGDVLQWAFTDTFLNLTLKQVHLLDWLEARCPHARFLLSGDDDVFVHTANVLRFLEAKSPDRHLFAGQLMSGSVPIRESWSKYFVPPQLFPGSVYPVYCSGGGFLLSRYTVKALRQAARHTPLFPIDDAYMGMCLERVGLKPSGHEGIRPFGVQLPGARQPSFDPCMYRELLLVHRFAPYEMLLMWKALHNPGLSCHRGHRVS", "length": 382, "header": "tr|F1MGN7-1|F1MGN7_BOVIN Isoform 1 of Hexosyltransferase OS=Bos taurus OX=9913 GN=B3GNT6 PE=3 SV=3 CANONICAL=F1MGN7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2C3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2C3/entry", "sequence": { "sequence": "MAFPCRKFLKPKILTCLLAGLSFSILHHWFLRDPRFQQKQRSDGSLQVTHVAPAAMSPSSPGPPCVANASANATADFEKLPERIQDFLRYRHCRHFPLLWDAPAKCRGSRGPFLLLAVKSAPANFERRELIRRTWGQERSYGGRPVRRLFLLGTPAPEDAERAEQLAELAALEAREHGDVLQWAFTDTFLNLTLKQVHLLDWLEARCPHARFLLSGDDDVFVHTANVLRFLEAKSPDRHLFAGQLMSGSVPIRESWSKYFVPPQLFPGSVYPVYCSGGGFLLSRYTVKALRQAARHTPLFPIDDAYMGMCLERVGLKPSGHEGIRPFGVQLPGARQPSFDPCMYRELLLVHRFAPYEMLLMWKALHNPGLSCHRGHRVS", "length": 379, "header": "tr|A0AAA9S2C3-1|F1MGN7_BOVIN Computationally mapped isoform of Hexosyltransferase OS=Bos taurus OX=9913 GN=B3GNT6 PE=3 SV=1 CANONICAL=F1MGN7-1" }, "locus": { "chromosome": "15", "start_pos": 56453577, "end_pos": 56452441, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131794.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131794.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093799.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093799.1" } ] } }, { "isoform_ac": "F1MGN7-1", "url": "https://www.uniprot.org/uniprotkb/F1MGN7/entry", "sequence": { "sequence": "MIQMAFPCRKFLKPKILTCLLAGLSFSILHHWFLRDPRFQQKQRSDGSLQVTHVAPAAMSPSSPGPPCVANASANATADFEKLPERIQDFLRYRHCRHFPLLWDAPAKCRGSRGPFLLLAVKSAPANFERRELIRRTWGQERSYGGRPVRRLFLLGTPAPEDAERAEQLAELAALEAREHGDVLQWAFTDTFLNLTLKQVHLLDWLEARCPHARFLLSGDDDVFVHTANVLRFLEAKSPDRHLFAGQLMSGSVPIRESWSKYFVPPQLFPGSVYPVYCSGGGFLLSRYTVKALRQAARHTPLFPIDDAYMGMCLERVGLKPSGHEGIRPFGVQLPGARQPSFDPCMYRELLLVHRFAPYEMLLMWKALHNPGLSCHRGHRVS", "length": 382, "header": "tr|F1MGN7-1|F1MGN7_BOVIN Isoform 1 of Hexosyltransferase OS=Bos taurus OX=9913 GN=B3GNT6 PE=3 SV=3 CANONICAL=F1MGN7-1" }, "locus": { "chromosome": "15", "start_pos": 56453577, "end_pos": 56451900, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063600.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063600.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054309.3", "url": "https://www.ensembl.org/id/ENSBTAP00000054309.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-913709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "resource": "Reactome", "description": "O-linked glycosylation of mucins" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZC66-1", "protein_name": "Hexosyltransferase", "gene_name": "B3gnt6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALPCSRRSKTPKTLAFLLVGMTFVVLNQWLLQEPMREKANGSVVTPWSSEAAVLRLPLLPAPPCAANVSVDLLDGFQELPARIQDFLRYRHCRRFPQLWDAPHKCVGPRGVFLLLAVKSSPAHYERRELIRRTWGQERSYSGQQVRRLFLVGTSSPEEAAREPQLADLLSLEAREHGDVLQWDFKDTFLNLTLKHLHLLDWTEEHCPGMSFLLSCDDDVFVHTANVLRFLEVQSPERHLFTGQLMAGSVPIRESWSKYFVPRQLFPGTAYPVYCSGGGFLMSRRTAQDLRRASHHVPLFPIDDAYMGMCLQQAGLAPSNHEGIRPFGVQLPGTKRSSFDPCMYRELLLVHRFAPYEMLLMWKALHDPALQCSHRQDAGSPEARGEMISDAH", "length": 392 }, "evidence": [ { "id": "F1MGN7", "url": "https://omabrowser.org/oma/group/F1MGN7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3USF0-1", "protein_name": "Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase", "gene_name": "B3gnt6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MALPSSRRFKSPTTLAFFLVGVTLVVLNQWFLQEHRQEKAKGPVATRRSLAAVVQRSPLFQVPPCVANASANLLTGFQLLPARIQDFLRYRHCRRFPQLWDAPPKCAGPRGVFLLLAVKSSPAHYERRELIRRTWGQERSYSGRQVLRLFLVGTSPPEEAAREPQLADLLSLEAREYGDVLQWDFSDTFLNLTLKHLHLLDWTAEHCPGVSFLLSCDDDVFVHTANVLSFLEVQSPEHHLFTGQLMVGSVPVRESGSKYFVPPQIFPGVAYPAYCSGGGFLLSRYTVRNLRSAAHHVPLFPIDDAYMGMCLQQAGLAPSSHQGIRPFGVQLPNVQRLSLDPCMYRELLLVHRFAPYEMLLMWKALHNPALHCSHKQVAGSPTAGEQNPDAH", "length": 391 }, "evidence": [ { "id": "F1MGN7", "url": "https://omabrowser.org/oma/group/F1MGN7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6ZMB0-1", "protein_name": "Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase", "gene_name": "B3GNT6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAFPCRRSLTAKTLACLLVGVSFLALQQWFLQAPRSPREERSPQEETPEGPTDAPAADEPPSELVPGPPCVANASANATADFEQLPARIQDFLRYRHCRHFPLLWDAPAKCAGGRGVFLLLAVKSAPEHYERRELIRRTWGQERSYGGRPVRRLFLLGTPGPEDEARAERLAELVALEAREHGDVLQWAFADTFLNLTLKHLHLLDWLAARCPHARFLLSGDDDVFVHTANVVRFLQAQPPGRHLFSGQLMEGSVPIRDSWSKYFVPPQLFPGSAYPVYCSGGGFLLSGPTARALRAAARHTPLFPIDDAYMGMCLERAGLAPSGHEGIRPFGVQLPGAQQSSFDPCMYRELLLVHRFAPYEMLLMWKALHSPALSCDRGHRVS", "length": 384 }, "evidence": [ { "id": "F1MGN7", "url": "https://omabrowser.org/oma/group/F1MGN7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F1MGN7", "url": "https://www.uniprot.org/uniprotkb/F1MGN7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein O-linked glycosylation via N-acetyl-galactosamine", "id": "GO:0016266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016266", "evidence": [ { "database": "UniProtKB", "id": "F1MGN7", "url": "https://www.uniprot.org/uniprotkb/F1MGN7" } ], "pmid": "" }, { "name": "poly-N-acetyllactosamine biosynthetic process", "id": "GO:0030311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030311", "evidence": [ { "database": "UniProtKB", "id": "F1MGN7", "url": "https://www.uniprot.org/uniprotkb/F1MGN7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity", "id": "GO:0008499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008499", "evidence": [ { "database": "UniProtKB", "id": "F1MGN7", "url": "https://www.uniprot.org/uniprotkb/F1MGN7" } ], "pmid": "" }, { "name": "UDP-glycosyltransferase activity", "id": "GO:0008194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008194", "evidence": [ { "database": "UniProtKB", "id": "F1MGN7", "url": "https://www.uniprot.org/uniprotkb/F1MGN7" } ], "pmid": "" }, { "name": "galactosyltransferase activity", "id": "GO:0008378", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008378", "evidence": [ { "database": "UniProtKB", "id": "F1MGN7", "url": "https://www.uniprot.org/uniprotkb/F1MGN7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-914010", "name": "B3GNT6 transfers GlcNAc to Tn antigen", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q17QZ8-1", "A0AAA9TA32-1", "F1MG37-1", "F1MGN7-1", "F1MSS4-1" ], "evidence": [ { "id": "R-BTA-914010", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-914010" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9TA32", "gene_name": "B3GNT5", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9TA32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA32" } ] } ] }, { "uniprot_ac": "F1MG37", "gene_name": "B3GNT7", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F1MG37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG37" } ] } ] }, { "uniprot_ac": "F1MGN7", "gene_name": "B3GNT6", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F1MGN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGN7" } ] } ] }, { "uniprot_ac": "F1MSS4", "gene_name": "B3GNT4", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F1MSS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSS4" } ] } ] }, { "uniprot_ac": "Q17QZ8", "gene_name": "B3GNT9", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q17QZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MGN7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 382, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MGN7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MGN7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAV4/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "F1MAV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAV4/entry#names_and_taxonomy" } ] }, { "name": "BRCA1-associated RING domain protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005202844", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202844" } ] }, { "name": "RING-type E3 ubiquitin transferase BARD1", "type": "synonym", "evidence": [ { "id": "F1MAV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAV4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. 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"database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005202844", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202844", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S2D0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2D0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2D0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2D0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1T0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1T0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1T0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1T0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7K7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7K7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7K7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7K7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9V2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9V2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMS5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMS5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MAV4-1", "url": "https://www.uniprot.org/uniprotkb/F1MAV4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQGNRQPRVRSGNQPHPAPAMKPAGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGSECPVCYTPAWIQDVKINRQLDSMIQLCSKLQNLLHDTDLSDLKEKTSRKSLFNDAQSKKNSIKMWFSPRSKKVRYTVSKLSVQTQPSVKNDENAQQTSMYEFVSPSPPVEVSEGPKKPSTRSRKKQKKKTLAEVNRKWNLEAEKEDGDLDCKGESKEKLVSFCSQPSVIANLQINGEIDLLASGSVTESECLDEVFLPLAEHIESPEIESKNEVVTPEKTVSANYLPSKKSLPSGRNGKRGRHNRISSPVSKRCRSSSQSTGGNSVKQTVLLENMPLLGCSSPPSNKLKVGDTLSRNSRTILDESISLSPGTPPSTLNSPSYRRMMCSPSATKLWPISHTAVKRNHRGETLLHIASIKGDIPSVEYLLQSGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAVKNGHVDIVKLLLTYGASREAVNIFGLRPVDYADSENMKSLLLLPEKKESSSTSHCSVVNTGQRRDGPLVLIGSGLSSEQQKMLSELATILKAKKCAEFDGTVTHVIVPGDTVQSTLKCMLGILSGCWILKFEWVKACLQSKECEQEEKYEIPEGPQKSRLNREQLLPKLFDGCYFYLGGTFKHHPKDNLIKLVAAGGGQILIRKPKPDSDVTQSINTVAYHAKPDSDQRFCTQYIIYEDLSNHRPERVRQGKVWMAPSSWFIDCVMSFELLPLDN", "length": 773, "header": "tr|F1MAV4-1|F1MAV4_BOVIN Isoform 1 of BRCA1-associated RING domain protein 1 OS=Bos taurus OX=9913 GN=BARD1 PE=4 SV=3 CANONICAL=F1MAV4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2D0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2D0/entry", "sequence": { "sequence": "MQGNRQPRVRSGNQPHPAPAMKPAGRGAWAHSRAALDRLEKLLRCSRCNCVSDCIGSECPVCYTPAWIQDVKINRQLDSMIQLCSKLQNLLHDTDLSDLKEKTSRKSLFNDAQSKKNSIKMWFSPRSKKVRYTVSKLSVQTQPSVKNDENAQQTSMYEFVSPSPPVEVSEGPKKPSTRSRKKQKKKTLAEVNRKWNLEAEKEDGDLDCKGESKEKLVSFCSQPSVIANLQINGEIDLLASGSVTESECLDEVFLPLAEHIESPEIESKNEVVTPEKTVSANYLPSKKSLPSGRNGKRGRHNRISSPVSKRCRSSSQSTGGNSVKQTVLLENMPLLGCSSPPSNKLKVGDTLSRNSRTILDESISLSPGTPPSTLNSPSYRRMMCSPSATKLWPISHTAVKRNHRGETLLHIASIKGDIPSVEYLLQSGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAVKNGHVDIVKLLLTYGASREAVNIFGLRPVDYADSENMKSLLLLPEKKESSSTSHCSVVNTGQRRDGPLVLIGSGLSSEQQKMLSELATILKAKKCAEFDGTVTHVIVPGDTVQSTLKCMLGILSGCWILKFEWVKACLQSKECEQEEKYEIPEGPQKSRLNREQLLPKLFDGCYFYLGGTFKHHPKDNLIKLVAAGGGQILIRKPKPDSDVTQSINTVAYHAKPDSDQRFCTQYIIYEDLSNHRPERVRQGKVWMAPSSWFIDCVMSFELLPLDN", "length": 754, "header": "tr|A0AAA9S2D0-1|F1MAV4_BOVIN Computationally mapped isoform of BRCA1-associated RING domain protein 1 OS=Bos taurus OX=9913 GN=BARD1 PE=4 SV=1 CANONICAL=F1MAV4-1" }, "locus": { "chromosome": "2", "start_pos": 102854150, "end_pos": 102762085, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104736.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104736.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079194.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079194.1" } ] } }, { "isoform_ac": "A0AAA9T1T0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1T0/entry", "sequence": { "sequence": "MQGNRQPRVRSGNQPHPAPAMKPAGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGSECPVCYTPAWIQDVKINRQLDSMIQLCSKLQNLLHDTDLSGVKACLQSKECEQEEKYEIPEGPQKSRLNREQLLPKLFDGCYFYLGGTFKHHPKDNLIKLVAAGGGQILIRKPKPDSDVTQSINTVAYHAKPDSDQRFCTQYIIYEDLSNHRPERVRQGKVWMAPSSWFIDCVMSFELLPLDN", "length": 259, "header": "tr|A0AAA9T1T0-1|F1MAV4_BOVIN Computationally mapped isoform of BRCA1-associated RING domain protein 1 OS=Bos taurus OX=9913 GN=BARD1 PE=4 SV=1 CANONICAL=F1MAV4-1" }, "locus": { "chromosome": "2", "start_pos": 102854150, "end_pos": 102762085, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128602.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128602.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091693.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091693.1" } ] } }, { "isoform_ac": "A0AAA9T7K7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7K7/entry", "sequence": { "sequence": "MQGNRQPRVRSGNQPHPAPAMKPAGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGSECPVCYTPAWIQDVKINRQLDSMIQLCSKLQNLLHDTDLSGRHPFC", "length": 122, "header": "tr|A0AAA9T7K7-1|F1MAV4_BOVIN Computationally mapped isoform of BRCA1-associated RING domain protein 1 OS=Bos taurus OX=9913 GN=BARD1 PE=4 SV=1 CANONICAL=F1MAV4-1" }, "locus": { "chromosome": "2", "start_pos": 102854150, "end_pos": 102805383, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104559.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104559.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091830.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091830.1" } ] } }, { "isoform_ac": "A0AAA9T9V2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9V2/entry", "sequence": { "sequence": "MQGNRQPRVRSGNQPHPAPAMKPAGRGAWAHSRAALDRLEKLLRCSRCNIFGLRPVDYADSENMKSLLLLPEKKESSSTSHCSVVNTGQRRDGPLVLIGSGLSSEQQKMLSELATILKAKKCAEFDGTVTHVIVPGDTVQSTLKCMLGILSGCWILKFEWVKACLQSKECEQEEKYEIPEGPQKSRLNREQLLPKLFDGCYFYLGGTFKHHPKDNLIKLVAAGGGQILIRKPKPDSDVTQSINTVAYHAKPDSDQRFCTQYIIYEDLSNHRPERVRQGKVWMAPSSWFIDCVMSFELLPLDN", "length": 302, "header": "tr|A0AAA9T9V2-1|F1MAV4_BOVIN Computationally mapped isoform of BRCA1-associated RING domain protein 1 OS=Bos taurus OX=9913 GN=BARD1 PE=4 SV=1 CANONICAL=F1MAV4-1" }, "locus": { "chromosome": "2", "start_pos": 102854150, "end_pos": 102762085, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107123.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107123.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094793.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094793.1" } ] } }, { "isoform_ac": "A0AAA9TMS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMS5/entry", "sequence": { "sequence": "MQGNRQPRVRSGNQPHPAPAMKPAGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNIFGLRPVDYADSENMKSLLLLPEKKESSSTSHCSVVNTGQRRDGPLVLIGSGLSSEQQKMLSELATILKAKKCAEFDGTVTHVIVPGDTVQSTLKCMLGILSGCWILKFEWVKACLQSKECEQEEKYEIPEGPQKSRLNREQLLPKLFDGCYFYLGGTFKHHPKDNLIKLVAAGGGQILIRKPKPDSDVTQSINTVAYHAKPDSDQRFCTQYIIYEDLSNHRPERVRQGKVWMAPSSWFIDCVMSFELLPLDN", "length": 321, "header": "tr|A0AAA9TMS5-1|F1MAV4_BOVIN Computationally mapped isoform of BRCA1-associated RING domain protein 1 OS=Bos taurus OX=9913 GN=BARD1 PE=4 SV=1 CANONICAL=F1MAV4-1" }, "locus": { "chromosome": "2", "start_pos": 102854150, "end_pos": 102762085, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129718.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129718.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098289.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098289.1" } ] } }, { "isoform_ac": "F1MAV4-1", "url": "https://www.uniprot.org/uniprotkb/F1MAV4/entry", "sequence": { "sequence": "MQGNRQPRVRSGNQPHPAPAMKPAGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGSECPVCYTPAWIQDVKINRQLDSMIQLCSKLQNLLHDTDLSDLKEKTSRKSLFNDAQSKKNSIKMWFSPRSKKVRYTVSKLSVQTQPSVKNDENAQQTSMYEFVSPSPPVEVSEGPKKPSTRSRKKQKKKTLAEVNRKWNLEAEKEDGDLDCKGESKEKLVSFCSQPSVIANLQINGEIDLLASGSVTESECLDEVFLPLAEHIESPEIESKNEVVTPEKTVSANYLPSKKSLPSGRNGKRGRHNRISSPVSKRCRSSSQSTGGNSVKQTVLLENMPLLGCSSPPSNKLKVGDTLSRNSRTILDESISLSPGTPPSTLNSPSYRRMMCSPSATKLWPISHTAVKRNHRGETLLHIASIKGDIPSVEYLLQSGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAVKNGHVDIVKLLLTYGASREAVNIFGLRPVDYADSENMKSLLLLPEKKESSSTSHCSVVNTGQRRDGPLVLIGSGLSSEQQKMLSELATILKAKKCAEFDGTVTHVIVPGDTVQSTLKCMLGILSGCWILKFEWVKACLQSKECEQEEKYEIPEGPQKSRLNREQLLPKLFDGCYFYLGGTFKHHPKDNLIKLVAAGGGQILIRKPKPDSDVTQSINTVAYHAKPDSDQRFCTQYIIYEDLSNHRPERVRQGKVWMAPSSWFIDCVMSFELLPLDN", "length": 773, "header": "tr|F1MAV4-1|F1MAV4_BOVIN Isoform 1 of BRCA1-associated RING domain protein 1 OS=Bos taurus OX=9913 GN=BARD1 PE=4 SV=3 CANONICAL=F1MAV4-1" }, "locus": { "chromosome": "2", "start_pos": 102854150, "end_pos": 102762085, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047858.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047858.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045022.4", "url": "https://www.ensembl.org/id/ENSBTAP00000045022.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-5685938", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685938", "resource": "Reactome", "description": "HDR through Single Strand Annealing (SSA)" }, { "id": "R-BTA-5685942", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685942", "resource": "Reactome", "description": "HDR through Homologous Recombination (HRR)" }, { "id": "R-BTA-5689603", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689603", "resource": "Reactome", "description": "UCH proteinases" }, { "id": "R-BTA-5689901", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689901", "resource": "Reactome", "description": "Metalloprotease DUBs" }, { "id": "R-BTA-5693537", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693537", "resource": "Reactome", "description": "Resolution of D-Loop Structures" }, { "id": "R-BTA-5693565", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693565", "resource": "Reactome", "description": "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" }, { "id": "R-BTA-5693568", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693568", "resource": "Reactome", "description": "Resolution of D-loop Structures through Holliday Junction Intermediates" }, { "id": "R-BTA-5693571", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693571", "resource": "Reactome", "description": "Nonhomologous End-Joining (NHEJ)" }, { "id": "R-BTA-5693579", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693579", "resource": "Reactome", "description": "Homologous DNA Pairing and Strand Exchange" }, { "id": "R-BTA-5693607", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693607", "resource": "Reactome", "description": "Processing of DNA double-strand break ends" }, { "id": "R-BTA-5693616", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693616", "resource": "Reactome", "description": "Presynaptic phase of homologous DNA pairing and strand exchange" }, { "id": "R-BTA-6804756", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804756", "resource": "Reactome", "description": "Regulation of TP53 Activity through Phosphorylation" }, { "id": "R-BTA-69473", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69473", "resource": "Reactome", "description": "G2/M DNA damage checkpoint" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2RET1-1", "protein_name": "BRCA1-associated RING domain protein 1", "gene_name": "BARD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPGNRLPRVRSGNEPHPAPSMEPAGRGAWAHSRAALARLEKLLRCSRCTDILREPVCLGGCEHIFCSNCISDCFGSGCPVCYTPAWIQDVKINRQLDSMIQLCSKLRNLLHDADSSDLKEETSRKSLFSDAEYKKNSIKMWFSPRSKKVRYVVSKVSVQTHPPMINDENAQQASLYEFVSTSPPVDVSERAKKASTRCRKKQKKKTLAEINQKWNLEAEKEDGKLDSKEEFKEKLVSFCSQPSVIASPQMNGEIDLLASGSVTESECLGSFTEVSLPLAEHIESPEMESKNEAVTPEKTLCENVLDESKKSLPSRHNGNRGCRSRLTSPVSKRCRNSIPSTSGNSVKQTVLSENVPSPGCSSPPSNKLKRGATLRRKTSNILDESISLSPGTPPSTLNSPSYRRMMSSPSAVKLSPSSLTAVKRNHRGETLLHIASIKGDIPSVEYLLGNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAVKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDSENMKSLLLLPEKDESSSTSHCSAVNTGQRRDGPLVLIGSGLSSEQQKMLSELAAMLKAKKCAEFDSAVTHVVVPGDTVQSTLKCMLGILSGCWILKFEWVKACLQRKKCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYFGGTFKHHPKDNLIKLVTAAGGQILSRKPKPDSDVTQTINTVAYHAKPDSDQRFCTQYIIYEDLSNHRPERVRQGKVWMAPSSWFIDCVMSFELLPLDS", "length": 777 }, "evidence": [ { "id": "F1MAV4", "url": "https://omabrowser.org/oma/group/F1MAV4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YD08-1", "protein_name": "BRCA1 associated RING domain 1", "gene_name": "BARD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MREVLRGRSGNRPAPGGQPGPAASMARPWAHTRAALERLERALSCSRCAGVLREPVSLGGCEHVFCLSCMGDHVGKGCPVCHVPAWVQDMQINRQLDDMVQLCGKLRHLLDAGTSDSMESTPTPMCSDFGENSKKGQIKMWFSPRSRKIRCIVNKNQPKTNSNDLCQDPSSVYHFFPSPVHEKPSKPTKKPTQRQSKKMKKKRLADINKAWGLEKPEQKEGVEEKASKEKCVTICNEPVVLCTPEQHSPKETLPQESIQEVDSTKNLVEVEVSPEVKSSQEEDNNKAVCPVQVSKETNCAAEKSPSIESKAMHLKRGREQSKLPGTSQTKRRRSEGSLNRNSDSQTSCSEDLSQDCPIPQVTEPRTPVQVCGSAMKTRSSAASSPLLPKSPSTPSTFKACDQVGIPQSPSVFKSPGSNPIARRNYKGETLLHIASIKGDLAAVEELLKNGADPNVKDNAGWTPLHEACNHGHQEVVELLLQHKALVNSTGYQNDSPLHDAAKNGHVSIVELLLLHGASRDAVPNVNGAQFHLTIWSKSFNPQQHGGFLLLFNLTADRFDNIFGLRPVDYAESEKMKSVLMLPVKNESFSFSQPSESPSQPRDGPLGILGSGLSSKQQKLLNKLATVLKARRCTEFNSTVTHVVVPDVPMPSTVKCMMAVLSGCWVLKFEWVQACLQSTVREQEEKYEIQGGPQRGRLNREQLLPKLFDGCYFYFLGSFNSHQKSDLVELVKAGGGQILVRQPKPDSDVTQTINTVAYHAESTSDQRFCTQYVIYDASSKFKPEKIRQGKVWFAPSSWIVDCIMSFQLLPVK", "length": 811 }, "evidence": [ { "id": "F1MAV4", "url": "https://omabrowser.org/oma/group/F1MAV4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O70445-1", "protein_name": "BRCA1-associated RING domain protein 1", "gene_name": "Bard1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRRPPRVCSGNQPAPVPAMEPATDGLWAHSRAALARLEKLLRCSRCANILKEPVCLGGCEHIFCSGCISDCVGSGCPVCYTPAWILDLKINRQLDSMIQLSSKLQNLLHDNKDSKDNTSRASLFGDAERKKNSIKMWFSPRSKKVRYVVTKVSVQTQPQKAKDDKAQEASMYEFVSATPPVAVPKSAKTASRTSAKKHPKKSVAKINREENLRPETKDSRFDSKEELKEEKVVSCSQIPVMERPRVNGEIDLLASGSVVEPECSGSLTEVSLPLAEHIVSPDTVSKNEETPEKKVCVKDLRSGGSNGNRKGCHRPTTSTSDSCGSNIPSTSRGIGEPALLAENVVLVDCSSLPSGQLQVDVTLRRKSNASDDPLSLSPGTPPPLLNNSTHRQMMSSPSTVKLSSGMPARKRNHRGETLLHIASIKGDIPSVEYLLQNGNDPNVKDHAGWTPLHEACSHGHLKVVELLLQHNALVNTPGYQNDSPLHDAVKSGHIDIVKVLLSHGASRNAVNIFGVRPVDYTDNENIRSLLLLPEENESFSTSQCSIVNTGQRKNGPLVFIGSGLSSQQQKMLSKLETVLKAKKCMEFDSTVTHVIVPDEEAQSTLKCMLGILSGCWILKFDWVKACLDSKVREQEEKYEVPGGPQRSRLNREQLLPKLFDGCYFFLGGNFKHHPRDDLLKLIAAAGGKVLSRKPKPDSDVTQTINTVAYHAKPESDQRFCTQYIVYEDLFNCHPERVRQGKVWMAPSTWLISCIMAFELLPLDS", "length": 765 }, "evidence": [ { "id": "F1MAV4", "url": "https://omabrowser.org/oma/group/F1MAV4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99728-1", "protein_name": "BRCA1-associated RING domain protein 1", "gene_name": "BARD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS", "length": 777 }, "evidence": [ { "id": "F1MAV4", "url": "https://omabrowser.org/oma/group/F1MAV4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QZH2-1", "protein_name": "BRCA1-associated RING domain protein 1", "gene_name": "Bard1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPRRPPRVCSGNKPPPVPAMEPATDGLWAHSRAALARLEKLLRCSRCANILREPVCLGGCEHIFCSGCISDCVGSGCPVCHTPAWILDLKINRQLDSMIQLYSKLQNLLHDNKGSDSKDDTSRASLFGDAERKKNSVKMWFSPRSKKIRCVVNKVSVQTQPQKAKDDKAQEASVFEFVSATPPVVVSTRAKTASRTSAKKHPKKSVAKINREGNFRPETRDSRFDSKEKLKEEKVVSFSQTLVMENSRVNGEIDLLASGSVVESVFSGSFAEVSLPLAEHIVSPDTVSKSEEAPEKKVCVEDRCPVGSDGNPKGCHRPPTSTSKKCGSNVPSASGEIREPTLLAENVVLVDCSSLPSGRLQVDVTLRRQSNASDDSLSLSPGTPPSLLNNSTHRQMMSKPSTVKLSSGIPARKRNHRGETLLHIASIKGDISSVEYLLQNGNDPNVKDHAGWTPLHEACSHGHLKIVELLLQHNALVNTTGYHNDSPLHDAAKNGHIDIVKVLLSHGASRNAVNIFGERPVDYTDAENIRSLLLLPEKTDSFSTSQCSVQVNTGQRKSGPLVLIGSGLSSQQQKLLSKLETVLKAKKCAEFDNTVTHVIVPDEEAQSTLKCMLGILNGCWVLKFDWVKACLDSQEREQEEKYEVPGGPQRSRLNREQLLPKLFDGCYFFLGGNFKHHPKEDLLKLIAAAGGRILSRKPKPDSDVTQTINTVAYHAKPDSDQRFCTQYIVYEDLFNCHPERVRQGKVWMAPSTWLISCVMAFELLPLDS", "length": 768 }, "evidence": [ { "id": "F1MAV4", "url": "https://omabrowser.org/oma/group/F1MAV4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "BRCA1-A complex", "id": "GO:0070531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070531", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "BRCA1-BARD1 complex", "id": "GO:0031436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031436", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "DNA damage tolerance", "id": "GO:0006301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006301", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "protein monoubiquitination", "id": "GO:0006513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006513", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "cellular response to ionizing radiation", "id": "GO:0071479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071479", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "negative regulation of protein export from nucleus", "id": "GO:0046826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046826", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "protein K6-linked ubiquitination", "id": "GO:0085020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0085020", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "F1MAV4", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 484, "end_pos": 486, "annotation": "n_glycosylation_sequon" }, { "start_pos": 490, "end_pos": 492, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-5659781", "name": "BRCA1 forms a heterodimer with BARD1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SKW6-1", "F1MAV4-1" ], "evidence": [ { "id": "R-BTA-5659781", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5659781" } ] }, { "id": "R-BTA-5683385", "name": "Formation of BRCA1-A complex at DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0P5K3-1", "F1MMY4-1", "A0AAA9SKW6-1", "Q0IIM1-1", "Q2HJ46-1", "E1B782-1", "E1BEI6-1", "F1MAV4-1", "A5PJP6-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5683385", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5683385" } ] }, { "id": "R-BTA-5683735", "name": "CHEK2 is recruited to DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0P5K3-1", "F1MMY4-1", "A0AAA9SKW6-1", "Q0IIM1-1", "Q2HJ46-1", "E1B782-1", "E1BEI6-1", "F1MAV4-1", "A5PJP6-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5683735", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5683735" } ] }, { "id": "R-BTA-5683801", "name": "CHEK2 phosphorylates BRCA1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0P5K3-1", "F1MMY4-1", "A0AAA9SKW6-1", "Q0IIM1-1", "Q2HJ46-1", "E1B782-1", "E1BEI6-1", "F1MAV4-1", "A5PJP6-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5683801", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5683801" } ] }, { "id": "R-BTA-5684052", "name": "PIAS4 SUMOylates MDC1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0P5K3-1", "F1MMY4-1", "A0AAA9SKW6-1", "Q0IIM1-1", "Q2HJ46-1", "E1B782-1", "E1BEI6-1", "F1MAV4-1", "A5PJP6-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5684052", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5684052" } ] }, { "id": "R-BTA-5684071", "name": "RNF4 ubiquitinates MDC1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0P5K3-1", "F1MMY4-1", "A0AAA9SKW6-1", "Q0IIM1-1", "Q2HJ46-1", "E1B782-1", "E1BEI6-1", "F1MAV4-1", "A5PJP6-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5684071", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5684071" } ] }, { "id": "R-BTA-5684108", "name": "BRCA1 binds phosphorylated RBBP8", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SKW6-1", "E1BEI6-1", "F1MAV4-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5684108", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5684108" } ] }, { "id": "R-BTA-5684875", "name": "Binding of ATR:ATRIP to RPA at resected DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MLY7-1", "F1MMS0-1", "A0AAA9SKW6-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5684875", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5684875" } ] }, { "id": "R-BTA-5685011", "name": "ATR activation at DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MLY7-1", "F1MMS0-1", "A0AAA9SKW6-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5685011", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685011" } ] }, { "id": "R-BTA-5685156", "name": "ATR phosphorylates RPA2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MLY7-1", "F1MMS0-1", "A0AAA9SKW6-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5685156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685156" } ] }, { "id": "R-BTA-5685341", "name": "BCDX2 complex stabilizes RAD51 filament", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MMS0-1", "A0AAA9SKW6-1", "Q2KJ94-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5685341", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685341" } ] }, { "id": "R-BTA-5685838", "name": "CX3 complex binds D-loop structures", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MMS0-1", "A0AAA9SKW6-1", "Q2KJ94-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5685838", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685838" } ] }, { "id": "R-BTA-5685985", "name": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MMS0-1", "A0AAA9SKW6-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5685985", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685985" } ] }, { "id": "R-BTA-5685994", "name": "Long-range resection of DNA DSBs by EXO1 or DNA2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MMS0-1", "A0AAA9SKW6-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5685994", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5685994" } ] }, { "id": "R-BTA-5686440", "name": "MUS81:EME1,EME2 cleaves D-loop", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MMS0-1", "A0AAA9SKW6-1", "Q2KJ94-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5686440", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5686440" } ] }, { "id": "R-BTA-5686642", "name": "RAD52 promotes single strand annealing at resected DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MLY7-1", "F1MMS0-1", "A0AAA9SKW6-1", "Q2KJ94-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5686642", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5686642" } ] }, { "id": "R-BTA-5686657", "name": "ERCC1:XPF cleaves flaps generated by SSA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MLY7-1", "F1MMS0-1", "A0AAA9SKW6-1", "Q2KJ94-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5686657", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5686657" } ] }, { "id": "R-BTA-5686663", "name": "Completion of SSA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MLY7-1", "F1MMS0-1", "A0AAA9SKW6-1", "Q2KJ94-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3S5ZPU0-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5686663", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5686663" } ] }, { "id": "R-BTA-5686685", "name": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-480742", "R-BTA-5619395" ], "output_participant_list": [ "R-BTA-5682574", "R-BTA-5682575", "R-BTA-5682577", "R-BTA-5682579", "R-BTA-5682582" ], "enzyme_list": [ "Q0P5K3-1", "F1MMY4-1", "A0AAA9SKW6-1", "Q0IIM1-1", "Q2HJ46-1", "E1B782-1", "E1BEI6-1", "F1MAV4-1", "A5PJP6-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5686685", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5686685" } ] }, { "id": "R-BTA-5689649", "name": "BAP1 binds BRCA1:BARD1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MAV4-1", "G3MYU1-1" ], "evidence": [ { "id": "R-BTA-5689649", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689649" } ] }, { "id": "R-BTA-5691411", "name": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SKW6-1", "F1MAV4-1", "A5PJP6-1" ], "evidence": [ { "id": "R-BTA-5691411", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5691411" } ] }, { "id": "R-BTA-5693539", "name": "Ligation of DNA and formation of Holliday structures following repair synthesis", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MMS0-1", "A0AAA9SKW6-1", "Q2KJ94-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5693539", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693539" } ] }, { "id": "R-BTA-5693542", "name": "Association of RPA complexes with ssDNA at resected DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MMS0-1", "A0AAA9SKW6-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5693542", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693542" } ] }, { "id": "R-BTA-5693551", "name": "Phosphorylation of BRCA1-A complex at multiple sites by ATM", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q0P5K3-1", "F1MMY4-1", "A0AAA9SKW6-1", "Q0IIM1-1", "Q2HJ46-1", "E1B782-1", "E1BEI6-1", "F1MAV4-1", "A5PJP6-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5693551", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693551" } ] }, { "id": "R-BTA-5693564", "name": "Association of RAD51 with RAD52:DNA double-strand break ends", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MLY7-1", "F1MMS0-1", "A0AAA9SKW6-1", "Q2KJ94-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5693564", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693564" } ] }, { "id": "R-BTA-5693580", "name": "Association of RAD52 with the RPA complex at resected DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MLY7-1", "F1MMS0-1", "A0AAA9SKW6-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5693580", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693580" } ] }, { "id": "R-BTA-5693584", "name": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MMS0-1", "A0AAA9SKW6-1", "Q2KJ94-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "Q32PI0-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5693584", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693584" } ] }, { "id": "R-BTA-5693593", "name": "D-loop extension by DNA polymerases", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BNZ6-1", "F1MMS0-1", "A0AAA9SKW6-1", "Q2KJ94-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9SFP0-1", "A0AAA9TDU0-1", "A0AAA9RXS9-1", "F1MAV4-1", "A0AAA9SV16-1", "F1MZ79-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5693593", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693593" } ] }, { "id": "R-BTA-5693608", "name": "Initial resection of double-strand break ends", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SKW6-1", "E1BEI6-1", "F1MAV4-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5693608", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693608" } ] }, { "id": "R-BTA-5693620", "name": "D-loop formation mediated by PALB2, BRCA2 and RAD51", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "chromosome, nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MMS0-1", "A0AAA9SKW6-1", "Q2KJ94-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-5693620", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5693620" } ] }, { "id": "R-BTA-6799332", "name": "ATR phosphorylates TP53", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MLY7-1", "F1MMS0-1", "A0AAA9SKW6-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-6799332", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799332" } ] }, { "id": "R-BTA-69891", "name": "Phosphorylation and activation of CHEK2 by ATM", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-BTA-113825" ], "enzyme_list": [ "Q0P5K3-1", "F1MMY4-1", "A0AAA9SKW6-1", "Q0IIM1-1", "Q2HJ46-1", "E1B782-1", "E1BEI6-1", "F1MAV4-1", "A5PJP6-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-69891", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-69891" } ] }, { "id": "R-BTA-9700998", "name": "BAP1 disrupts the BRCA1:BARD1 heterodimer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SKW6-1", "F1MAV4-1", "G3MYU1-1" ], "evidence": [ { "id": "R-BTA-9700998", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9700998" } ] }, { "id": "R-BTA-9701000", "name": "BRCA1:BARD1 heterodimer autoubiquitinates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SKW6-1", "F1MAV4-1", "G3MYU1-1" ], "evidence": [ { "id": "R-BTA-9701000", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9701000" } ] }, { "id": "R-BTA-9701003", "name": "BAP1 binds BRCA1:BARD1 heterodimer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SKW6-1", "F1MAV4-1", "G3MYU1-1" ], "evidence": [ { "id": "R-BTA-9701003", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9701003" } ] }, { "id": "R-BTA-9707051", "name": "UBXN1 binds BRCA1:BARD1 heterodimer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SKW6-1", "F1MAV4-1" ], "evidence": [ { "id": "R-BTA-9707051", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9707051" } ] }, { "id": "R-BTA-9853389", "name": "FIGNL1 binds RAD51", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MMS0-1", "A0AAA9SKW6-1", "Q2KJ94-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-9853389", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9853389" } ] }, { "id": "R-BTA-9980006", "name": "ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MLY7-1", "F1MMS0-1", "A0AAA9SKW6-1", "Q2KJ94-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-9980006", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9980006" } ] }, { "id": "R-BTA-9980021", "name": "LIG1 binds SSA sites", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MLY7-1", "F1MMS0-1", "A0AAA9SKW6-1", "Q2KJ94-1", "A0AAA9SD97-1", "E1BEI6-1", "E1BF15-1", "A0AAA9TDU0-1", "F1MAV4-1", "A0AAA9SV16-1", "A0A3S5ZPU0-1", "A0A3Q1MIR9-1" ], "evidence": [ { "id": "R-BTA-9980021", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9980021" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-113825", "participant_name": "phospho-CHEK2 [nucleoplasm]", "crossref": [ { "id": "ENSBTAT00000006518", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000004956", "database": "ENSEMBL", "url": "" }, { "id": "F6R5E4", "database": "UniProt", "url": "" }, { "id": "ENSBTAP00000006518", "database": "ENSEMBL", "url": "" }, { "id": "27286", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-480742", "participant_name": "RIF1 [nucleoplasm]", "crossref": [ { "id": "E1BCK1", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000021020", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000027997", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000027997", "database": "ENSEMBL", "url": "" }, { "id": "33965", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-5619395", "participant_name": "PAXIP1 [nucleoplasm]", "crossref": [ { "id": "A0JNA8", "database": "UniProt", "url": "" }, { "id": "NP_001071385.1", "database": "RefSeq", "url": "" }, { "id": "XP_059741522.1", "database": "RefSeq", "url": "" }, { "id": "32602", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-5682574", "participant_name": "UIMC1 [nucleoplasm]", "crossref": [ { "id": "ENSBTAP00000055437", "database": "ENSEMBL", "url": "" }, { "id": "NP_001106693.1", "database": "RefSeq", "url": "" }, { "id": "G3N0S0", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000001707", "database": "ENSEMBL", "url": "" }, { "id": "36657", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000065067", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-5682575", "participant_name": "phospho-ABRAXAS1 [nucleoplasm]", "crossref": [ { "id": "Q5E9P1", "database": "UniProt", "url": "" }, { "id": "53684", "database": "VGNC", "url": "" }, { "id": "NP_001015516.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-5682577", "participant_name": "BRCC3 [nucleoplasm]", "crossref": [ { "id": "NP_001422372.1", "database": "RefSeq", "url": "" }, { "id": "ENSBTAG00000007817", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000010280", "database": "ENSEMBL", "url": "" }, { "id": "A5PJP6", "database": "UniProt", "url": "" }, { "id": "NP_001069258.1", "database": "RefSeq", "url": "" }, { "id": "26555", "database": "VGNC", "url": "" }, { "id": "ENSBTAP00000010280", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-BTA-5682579", "participant_name": "BABAM2 [nucleoplasm]", "crossref": [ { "id": "26399", "database": "VGNC", "url": "" }, { "id": "XP_059747459.1", "database": "RefSeq", "url": "" }, { "id": "NP_001095744.1", "database": "RefSeq", "url": "" }, { "id": "A6QQW8", "database": "UniProt", "url": "" }, { "id": "XP_059747461.1", "database": "RefSeq", "url": "" }, { "id": "XP_059747460.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-BTA-5682582", "participant_name": "BABAM1 [nucleoplasm]", "crossref": [ { "id": "Q08E57", "database": "UniProt", "url": "" }, { "id": "XP_005208544.1", "database": "RefSeq", "url": "" }, { "id": "55198", "database": "VGNC", "url": "" }, { "id": "XP_005208543.1", "database": "RefSeq", "url": "" }, { "id": "NP_001070269.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MIR9", "gene_name": "KAT5", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "A0A3Q1MIR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIR9" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A3Q1MIR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIR9" } ] } ] }, { "uniprot_ac": "A0A3S5ZPU0", "gene_name": "LIG1", "activity": [ { "ec_number": "6.5.1.1", "activity": "ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.", "evidence": [ { "id": "A0A3S5ZPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPU0" } ] }, { "ec_number": "6.5.1.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPU0" } ] } ] }, { "uniprot_ac": "A0AAA9RXS9", "gene_name": "POLK", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0AAA9RXS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXS9" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0AAA9RXS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXS9" } ] } ] }, { "uniprot_ac": "A0AAA9SD97", "gene_name": "WRN", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SD97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD97" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9SD97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD97" } ] } ] }, { "uniprot_ac": "A0AAA9SFP0", "gene_name": "POLE", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0AAA9SFP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFP0" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0AAA9SFP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFP0" } ] } ] }, { "uniprot_ac": "A0AAA9SKW6", "gene_name": "BRCA1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9SKW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKW6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9SKW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKW6" } ] } ] }, { "uniprot_ac": "A0AAA9SV16", "gene_name": "TOP3A", "activity": [ { "ec_number": "5.6.2.1", "activity": "ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.", "evidence": [ { "id": "A0AAA9SV16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV16" } ] }, { "ec_number": "5.6.2.1", "activity": "", "evidence": [ { "id": "A0AAA9SV16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV16" } ] } ] }, { "uniprot_ac": "A0AAA9TDU0", "gene_name": "BLM", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TDU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU0" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9TDU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDU0" } ] } ] }, { "uniprot_ac": "A5PJP6", "gene_name": "BRCC3", "activity": [ { "ec_number": "3.4.19.-", "activity": "", "evidence": [ { "id": "A5PJP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJP6" } ] } ] }, { "uniprot_ac": "E1B782", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": 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"type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MAV4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MAV4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MAV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" }, { "id": "PS50172", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50172" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BRCT", "eco_id": "ECO_0000259", "start_pos": 566, "end_pos": 649, "start_aa": "Leu", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MAV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAV4" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 81, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.27", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.27", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.27" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 484, "end_pos": 486 }, { "start_pos": 490, "end_pos": 492 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MIU3-1", "uniprot_ac": "F1MIU3", "uniprot_id": "F1MIU3_BOVIN", "mass": { "chemical_mass": 113496.0, "monoisotopic_mass": 113496.0 }, "refseq": { "ac": "XP_002698024", "name": "transmembrane channel-like protein 5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698024" }, "gene_names": [ { "name": "TMC5", "type": "recommended", "evidence": [ { "id": "F1MIU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIU3" } ] }, { "name": "TMC5", "type": "synonym", "evidence": [ { "id": "XP_002698024", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698024" } ] } ], "protein_names": [ { "name": "Transmembrane channel-like protein", "type": "recommended", "evidence": [ { "id": "F1MIU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIU3/entry#names_and_taxonomy" } ] }, { "name": "transmembrane channel-like protein 5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002698024", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698024" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MIU3", "url": "https://www.uniprot.org/uniprotkb/F1MIU3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMC5", "url": "https://www.uniprot.org/uniprotkb/F1MIU3", "locus": { "chromosome": "25", "start_pos": 17094132, "end_pos": 17029435, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002097", "url": "https://www.ensembl.org/id/ENSBTAG00000002097" } ] } } ], "crossref": [ { "id": "F1MIU3", "url": "https://alphafold.ebi.ac.uk/entry/F1MIU3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002097", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002097", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513865", "url": "https://www.ncbi.nlm.nih.gov/gene/513865", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513865", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513865", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SLPHAYF", "url": "https://omabrowser.org/oma/group/SLPHAYF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MIU3", "url": "https://www.orthodb.org/?gene=F1MIU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23302", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23302", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23302:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23302:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07810", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07810", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002698024", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698024", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S3C9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3C9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S3C9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3C9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD79", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SD79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD79-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU80", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIU3", "url": "https://www.uniprot.org/uniprotkb/F1MIU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIU3-1", "url": "https://www.uniprot.org/uniprotkb/F1MIU3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFAYRNSAYEEDPDYPDYSGSQNHTQRYLKSPGPLNNSDEPSTRSNPYPAESRTSPDYLGSLAEPDYPGCQSNPDYPGTTSHPYSAGTDYPKPLAEPEYIGSRRNPYQPGSSGEPDYSQFQQNPDFPGSKGSGNYTGSRINPDYLDSLGEPDYPGAQENLNSSGPRASSNHPGSRRNPEHASPRVKAYTDSLGEPDYPGAESQSNHPHFFGEPDYLGAEDHRNSPNFWGEPDYPGAENGHDYGSSEDPEMARQMLSRTSSVQPSFHHEGVGPLGILGREDVDYPESIEMKSVGMANPYPGAPGNGYVNPAYVGDEGPGPAYGDPPLSGHDWLSSPQGQKLIESLITMTSRDRIKAIRNQPRTMEEKRNLRKMVDKEKSKKSRRILELNCCAQCLNSISLAYRRFKNNLSELLNSISLWQKTLKVIGGKFGTSVLSYFNFLRWLLKFNIFSFIVTFSFIIIPQLTVMEKNHLQFTGLEFLTGAGYFTNTVMYYGFYTNSTIQHDNSGASYNMQLAYIFTIGGCLVVCFFSLLFSMARYFRNNFINPHIYSRGIAKLIFCWDFTVTHESAVKLKQKNLSTEIRENLSEILQENVKLTFNQQFIRFSAHVAAWVVSSGVAITCCAAVYYLAENNLQFLANHSNPGAVLLLPFVVSCINLVVPRFYSMFRLVERYEMPRHEVYTLLIRNIFLKISIIGILCYYWLNTVALNSEECWETLIGQEIYRLLLMDFVFSLADSLLGEFLRRIIGMRLITSLGLQEFDIARNVLELIYAQTLVWIGTFFCPLLPFIQMITLFIMFYVKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLSFFIESIYRWINTLNQTPSYLWVVWIYQNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIDKLIKLQGMEKRANPTLFTLERRDLEQWGPQRVRQHDAPRDLRFRQSFQEDNPKA", "length": 993, "header": "tr|F1MIU3-1|F1MIU3_BOVIN Isoform 1 of Transmembrane channel-like protein OS=Bos taurus OX=9913 GN=TMC5 PE=3 SV=3 CANONICAL=F1MIU3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S3C9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3C9/entry", "sequence": { "sequence": "MFAYRNSAYEEDPDYPDYSGSQNHTQRYLKSPGPLNNSDEPSTRSNPYPAESRTSPDYLGSLAEPDYPGCQSNPDYPGTTSHPYSAGTDYPKPLAEPEYIGSRRNPYQPGSSGEPDYSQFQQNPDFPGSKGSGNYTGSRINPDYLDSLGEPDYPGAQENLNSSGPRASSNHPGSRRNPEHASPRVKAYTDSLGEPDYPGAESQSNHPHFFGEPDYLGAEDHRNSPNFWGEPDYPGAENGHDYGSSEDPEMARQMLSRTSSVQPSFHHEGVGPLGILGREDVDYPESIEMKSVGMANPYPGAPGNGYVNPAYVGDEGPGPAYGDPPLSGHDWLSSPQGQKLIESLITMTSRDRIKAIRNQPRTMEEKRNLRKMVDKEKSKKSRRILELNCCAQCLNSISLAYRRFKNNLSELLNSISLWQKTLKVIGGKFGTSVLSYFNFLRWLLKFNIFSFIVTFSFIIIPQLTVMEKNHLQFTGLEFLTGAGYFTNTVMYYGFYTNSTIQHDNSGASYNMQLAYIFTIGGCLVVCFFSLLFSMARYFRNNFINPHIYSRGIAKLIFCWDFTVTHESAVKLKQKNLSTEIRFLANHSNPGAVLLLPFVVSCINLVVPRFYSMFRLVERYEMPRHEVYTLLIRNIFLKISIIGILCYYWLNTVALNSEECWETLIGQEIYRLLLMDFVFSLADSLLGEFLRRIIGMRLITSLGLQEFDIARNVLELIYAQTLVWIGTFFCPLLPFIQMITLFIMFYVKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLSFFIESIYRWINTLNQTPSYLWVVWIYQNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIDKLIKLQGMEKRANPTLFTLERRDLEQWGPQRVRQHDAPRDLRFRQSFQEDNPKA", "length": 941, "header": "tr|A0AAA9S3C9-1|F1MIU3_BOVIN Computationally mapped isoform of Transmembrane channel-like protein OS=Bos taurus OX=9913 GN=TMC5 PE=3 SV=1 CANONICAL=F1MIU3-1" }, "locus": { "chromosome": "25", "start_pos": 17093128, "end_pos": 17038473, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100902.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100902.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077777.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077777.1" } ] } }, { "isoform_ac": "A0AAA9SD79-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SD79/entry", "sequence": { "sequence": "MFAYRNSAYEEDPDYPDYSGSQNHTQRYLKSPGPLNNSDEPSTRSNPYPAESRTSPDYLGSLAEPDYPGCQSNPDYPGTTSHPYSAGTDYPKPLAEPEYIGSRRNPYQPGSSGEPDYSQFQQNPDFPGSKGSGNYTGSRINPDYLDSLGEPDYPGAQENLNSSGPRASSNHPGSRRNPEHASPRVKAYTDSLGEPDYPGAESQSNHPHFFGEPDYLGAEDHRNSPNFWGEPDYPGAENGHDYGSSEDPEMARQMLSRTSSVQPSFHHEGVGPLGILGREDVDYPESIEMKSVGMANPYPGAPGNGYVNPAYVGDEGPGPAYGDPPLSGHDWLSSPQGQKLIESLITMTSRDRIKAIRNQPRTMEEKRNLRKMVDKEKSKKSRRILELNCCAQCLNSISLAYRRFKNNLSELLNSISLWQKTLKVIGGKFGTSVLSYFNFLRWLLKFNIFSFIVTFSFIIIPQLTVMEKNHLQFTGLEFLTGAGYFTNTVMYYGFYTNSTIQHDNSGASYNMQLAYIFTIGGCLVVCFFSLLFSMARYFRNNFINPHIYSRGIAKLIFCWDFTVTHESAVKLKQKNLSTEIRENLSEILQENVKLTFNQQFIRFSAHVAAWVVSSGVAITCCAAVYYLAENNLQFLANHSNPGAVLLLPFVVSCINLVVPRFYSMFRLVERYEMPRHEVYTLLIRNIFLKISIIGILCYYWLNTVALNSEECWETLIGQEIYRLLLMDFVFSLADSLLGEFLRRIIGMRLITSLGLQEFDIARNVLELIYAQTLVWIGTFFCPLLPFIQMITLFIMFYVKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIDKLIKLQGMEKRANPTLFTLERRDLEQWGPQRVRQHDAPRDLRFRQSFQEDNPKA", "length": 935, "header": "tr|A0AAA9SD79-1|F1MIU3_BOVIN Computationally mapped isoform of Transmembrane channel-like protein OS=Bos taurus OX=9913 GN=TMC5 PE=3 SV=1 CANONICAL=F1MIU3-1" }, "locus": { "chromosome": "25", "start_pos": 17093128, "end_pos": 17038473, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132066.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132066.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084073.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084073.1" } ] } }, { "isoform_ac": "A0AAA9SU80-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU80/entry", "sequence": { "sequence": "MLSGGQVNEIIVEVEHVPSGIQSHPSSSQIVPEKTPVNSNSILVSSISDSDVTDSQIFSNRNDKKGKQLLQFATPLKESFALTLHNSENTGLDTPHTSHENIQGQKLIESLITMTSRDRIKAIRNQPRTMEEKRNLRKMVDKEKSKKSRRILELNCCAQCLNSISLAYRRFKNNLSELLNSISLWQKTLKVIGGKFGTSVLSYFNFLRWLLKFNIFSFIVTFSFIIIPQLTVMEKNHLQFTGLEFLTGAGYFTNTVMYYGFYTNSTIQHDNSGASYNMQLAYIFTIGGCLVVCFFSLLFSMARYFRNNFINPHIYSRGIAKLIFCWDFTVTHESAVKLKQKNLSTEIRENLSEILQENVKLTFNQQFIRFSAHVAAWVVSSGVAITCCAAVYYLAENNLQFLANHSNPGAVLLLPFVVSCINLVVPRFYSMFRLVERYEMPRHEVYTLLIRNIFLKISIIGILCYYWLNTVALNSEECWETLIGQEIYRLLLMDFVFSLADSLLGEFLRRIIGMRLITSLGLQEFDIARNVLELIYAQTLVWIGTFFCPLLPFIQMITLFIMFYVKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLSFFIESIYRWINTLNQTPSYLWVVWIYQNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIDKLIKLQGMEKRANPTLFTLERRDLEQWGPQRVRQHDAPRDLRFRQSFQEDNPKA", "length": 760, "header": "tr|A0AAA9SU80-1|F1MIU3_BOVIN Computationally mapped isoform of Transmembrane channel-like protein OS=Bos taurus OX=9913 GN=TMC5 PE=3 SV=1 CANONICAL=F1MIU3-1" }, "locus": { "chromosome": "25", "start_pos": 17093128, "end_pos": 17049698, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099895.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099895.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086674.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086674.1" } ] } }, { "isoform_ac": "F1MIU3-1", "url": "https://www.uniprot.org/uniprotkb/F1MIU3/entry", "sequence": { "sequence": "MFAYRNSAYEEDPDYPDYSGSQNHTQRYLKSPGPLNNSDEPSTRSNPYPAESRTSPDYLGSLAEPDYPGCQSNPDYPGTTSHPYSAGTDYPKPLAEPEYIGSRRNPYQPGSSGEPDYSQFQQNPDFPGSKGSGNYTGSRINPDYLDSLGEPDYPGAQENLNSSGPRASSNHPGSRRNPEHASPRVKAYTDSLGEPDYPGAESQSNHPHFFGEPDYLGAEDHRNSPNFWGEPDYPGAENGHDYGSSEDPEMARQMLSRTSSVQPSFHHEGVGPLGILGREDVDYPESIEMKSVGMANPYPGAPGNGYVNPAYVGDEGPGPAYGDPPLSGHDWLSSPQGQKLIESLITMTSRDRIKAIRNQPRTMEEKRNLRKMVDKEKSKKSRRILELNCCAQCLNSISLAYRRFKNNLSELLNSISLWQKTLKVIGGKFGTSVLSYFNFLRWLLKFNIFSFIVTFSFIIIPQLTVMEKNHLQFTGLEFLTGAGYFTNTVMYYGFYTNSTIQHDNSGASYNMQLAYIFTIGGCLVVCFFSLLFSMARYFRNNFINPHIYSRGIAKLIFCWDFTVTHESAVKLKQKNLSTEIRENLSEILQENVKLTFNQQFIRFSAHVAAWVVSSGVAITCCAAVYYLAENNLQFLANHSNPGAVLLLPFVVSCINLVVPRFYSMFRLVERYEMPRHEVYTLLIRNIFLKISIIGILCYYWLNTVALNSEECWETLIGQEIYRLLLMDFVFSLADSLLGEFLRRIIGMRLITSLGLQEFDIARNVLELIYAQTLVWIGTFFCPLLPFIQMITLFIMFYVKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLSFFIESIYRWINTLNQTPSYLWVVWIYQNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIDKLIKLQGMEKRANPTLFTLERRDLEQWGPQRVRQHDAPRDLRFRQSFQEDNPKA", "length": 993, "header": "tr|F1MIU3-1|F1MIU3_BOVIN Isoform 1 of Transmembrane channel-like protein OS=Bos taurus OX=9913 GN=TMC5 PE=3 SV=3 CANONICAL=F1MIU3-1" }, "locus": { "chromosome": "25", "start_pos": 17093128, "end_pos": 17038473, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037444.7", "url": "https://www.ensembl.org/id/ENSBTAT00000037444.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037277.5", "url": "https://www.ensembl.org/id/ENSBTAP00000037277.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513865", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513865", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZFR8-1", "protein_name": "Transmembrane channel-like protein", "gene_name": "TMC5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSYHYNEAFENPAYRFSETLEVDRSRNYQENPFSYQNPYDSSSYSYQGEHRGRRQNYTPDIPMASLRHNSEYSDSLPRVEVLSRSGRSHDNLSFEPEPELAYNPQSSFSPLDDPYTHRFSSASEDDFVRRRNRRPSDVTMFSTQSQATPVCGEEEKLVGSLASMSKHERIKAIQKMPENMKRKREIRNKVLREITKKSGGCGTLCGCCTHCMRRAKVSFRRFRNSLSEYFHRLNFWHKTLKIIAGEFGTSVLSYFIFLKWLLNFNIFSFLINFGFITVPQFVTAEPNNLSFTGLELLTGAGYFQQTVLYYGFYTNATIRQRKNGASYNMQLAYIFTVGIYFVICLLILLFSMAKSFHRNFINTQVYSGNASKLLCAWDFNITNEKAVKLKQKNLSTQIKEDLAEGKKEAPKLSVTERIVRILIHLGSWAASLGTAVAACAGVYFLSINNLQLFMKGYRNDLESQAAMLVLAIVTSLLNVVLPFFYSWLGNLEKFQDPKNKIYVTIARIIILKISIIGILCYYWLNVVAASESQCWETLVGQDIYRLVLVDFIFCLLGSFFGEFLRRIIGTTVYIRLGVPEFDIGRSVLDLIYAQTLTWLKPSKECGPFRGLPSIYAAISEWVKILENYIDSKWVAWIYYNLITSELFFFILSVPILVFTYLYWQIIKGRKTVAKLFLEQIVNKGRDKRFLLEQIRMLQRKQNPSAPRRQDQQRSSWLDHSSMPPAQQEPNYLGRTFDRNRNASYDEYPYSAGISRGTGFPSDWETSQPSSSSGMSEAVALALRARQAAQLEDLQDDINFRP", "length": 801 }, "evidence": [ { "id": "F1MIU3", "url": "https://omabrowser.org/oma/group/F1MIU3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7FDU7-1", "protein_name": "Transmembrane channel-like protein", "gene_name": "tmc5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRRMSVYPQHGTALENLGLTAHEIQQEVENNTSELVSDLSDLSAGARFQAIRSLPMSYNERKAIRNRVNNIKLSKTILPTDCRQQVSLSFRRFRASLTSARQRLVVWQDTLKEIGGRFGTSVLSYFLFLKWLLKFNVFSFVINFCFITIPQIVHAPNISHVTGFRGLELLTGVGYFNQTVLFYGGYDGEVIVSKPAYNMQLAYFFTIAAYMVLCGLSLIYSMSRSFQKNFVLETGPVSGGAWRLLCSWDFSVVNEKAIQYNKNNLGIQLKESLSERLQMKNKISLSDRIKHLSLNLVAWLLCLLLALGSGAGIYFLGTEQLTFSFNQDPNDLVSEASTLLLPVVVSLINLIVPLLYSLIGKMETYSNPRAKIYISIARNIILKMSLLGILCFYWLNFVPDKIPCWESFVGQSVYRLLIIDFIFCLLGIFFGEFLRNVIGTMCIQSLGVPEFDIARNVLDLIYAQTLAWIGIYFSPLLPVMQVLKLFIIFYLKKLSLSMNCQPPKHTGRAAQIQTVFIALLFFPSFVGALSMVAFTVWSLQPSDQCGPFQGLKTPFHTIFNWTDSIQGPPETHWVWWIFENVLRSELFYYLISLIVLVITFFLWQITQGRKQLIKSLREQIVNGGKDKAFLLNKLQNIQRQRREIASYSPQPIRRSMRGSVRTVAQEFDQTTYYNPNWINTLPMDM", "length": 685 }, "evidence": [ { "id": "F1MIU3", "url": "https://omabrowser.org/oma/group/F1MIU3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q32NZ6-1", "protein_name": "Transmembrane channel-like protein 5", "gene_name": "Tmc5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSFHQNSSYMEDADYPGYSGSRNHTHNYLETQDYPEFPGSQNNPGFHHPRSNPHSSGSRTNPDYPYFQEEPDYPGSLSNTVYQDTRSHPFSAHSRTRPDYESSIEPDYNDFRSESYHAGLPMEPDYPGSQSHPGFAGVGRSSMNYTGPRTNLGYLGSLEEPDYPGAQDNSYYHSGSRPHSNLPGSRRDAGYAGSRINSYPDDLGEPDYPGAENQPNSPRFYGKPDYPGAEEGDGYSSSKSLAVIRRGNGPFGMLGRRNEDYPEGIGMVSMEMAGDPRNGYVNPAYTRRISPVCPDRNLLLCAHDWHTSVQGQKLIASLIPMTTRDRIKTIRNQPRTMQEKRELRKIVDKEKNKQSHGILEANCCAQCLGSLSLTYRRTRNGLSELLNYITLWQKRFKVIGGKFGTSVLSYFSFLRWLLKFNIFSFVMNFSFIIIPQFTVGAKNTLQFTGLEFFTGAGYFGDTVMYYGFYTNSTIRHRMGGASYNMQLAYIFTIGACLVVCFFSLLFSMAKYFRNNFINPHIYSRGIAKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQENYRLTFNQQLTRFSAHVAAWLVSTGVTAACCVAVYYLAEYNSEFLKTHRNPGAVLLLPFVVSCINLAVPRFYSMFRLVERYEIPRQEVYVLLVRNIFLKISIVGILCYYWLNIVALSGEECWETLIGQDIYRLLLMDFVFSLADSLLGEFLRRLIGMKFTSLSLQEFDIARNVLELIYAQTLTWLGIFFCPLLPFIQMITLFIMFYVKNVSLMMNFQPPSKAWRASQMITFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPSFIQSIYSWIDTLSRRPGYLWVVWIYQNLIGSVHFFFILTLIVLIITYLYWQITEGRKVMIRLLHEQIINEGKDKMFLIEKLTKLQDMEKRVNPSALDLERREVEPQIPLHLEELGAAPDLRLRRSAQEENPIA", "length": 967 }, "evidence": [ { "id": "F1MIU3", "url": "https://omabrowser.org/oma/group/F1MIU3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5M7W4-1", "protein_name": "Transmembrane channel-like protein 5", "gene_name": "Tmc5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSFHKNSSYMEDPDYPGYSGSQNHTQNYLRTQDDLEFPGCLDNPGFHHPRRNPYSSDSRTNPDYHHSLAEPDYPGSPSDADYQNTRCHPRSAHPRTRPDYEPDYEPDYNDFQSESYHPDLSMEPDYPGSHGHPGFAGVRSSVNSTGPRTNLGYLDLEEPDYPGAQGNSYHSGPRSHSNLPGSRRNAGYAGSRINSYPDSLGEPDYPGAENQPNSPDFYGKPDYPGAEEGDVYSPSKTLGVIGRSRGSFGILGREDGDYPEGIEMASLGMAGDPRNGYVNPAYMRGSSPVCPDRNLLLCARDWNTSPQGQKLIASLVPMTSRDRIKTIRNQPRTMQEKRELRKIVDKEKNKQSHGTFEANCCAQCLSSLSLAYRRTKSSLSELLNYISLWQKRFKVIGGKFGTSVLSYFSFLRWLLKFNIFSFVMNFSFIIIPQFTVGEKNTLQFTGLEFFTGAGYFRETVMYYGFYTNSTIRHRMGGASYNMQLAYIFTIGACLVICFFSLLFSMAKYFRNNFINPHIYSRGIAKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSEIRQENDRLTLNQKLTRFSVHVAAWLVSTGITAACCVAVYYLAEYNSEFLKTHKNPGAVLLLPFVVSCINLAVPRFYSMFRLVERYEIPRQEVYVLLIRNIFLKISIVGILCYYWLNIVALSGEECWETLIGQDIYRLLLMDFVFSLADSLLGEFLRRLIGMKFITSLSLQEFDIARNVLELIYAQTLAWLGIFFCPLLPFIQMITLFIMFYVKNVSLMMNFQPPSKAWRASQMITFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPSFIQSIYSWIDTLSHRPGYLWVVWIYQNLIGSVHFFFILTLIVLIITYLYWQITEGRKVMIRLLHEQIINEGKDKMFLIEKLTKLQDIERRANPSTLVLERREVEQQSPLHLEELDAAPDLRLRRSMQEENAIA", "length": 965 }, "evidence": [ { "id": "F1MIU3", "url": "https://omabrowser.org/oma/group/F1MIU3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6UXY8-1", "protein_name": "Transmembrane channel-like protein 5", "gene_name": "TMC5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAYYRNNWSEEDPDYPDYSGSQNRTQGYLKTQGYPDVPGPLNNPDYPGTRSNPYSVASRTRPDYPGSLAEPNYPRSLSNPDYSGTRSNAYSAASRTSPDHPTSLPEPDYSEFQSHPYHRASSRQPDYPGSQRNPDFAGSSSSGNYAGSRTHPDHFGSLEPDYPGAQSNSDHPGPRANLNHPGSRKNLEHTSFRINPYADSLGKPDYPGADIQPNSPPFFGEPDYPSAEDNQNLPSTWREPDYSDAENGHDYGSSETPKMTRGVLSRTSSIQPSFRHRSDDPVGSLWGENDYPEGIEMASMEMANSYGHSLPGAPGSGYVNPAYVGESGPVHAYGNPPLSECDWHKSPQGQKLIASLIPMTSRDRIKAIRNQPRTMEEKRNLRKIVDKEKSKQTHRILQLNCCIQCLNSISRAYRRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIPQFTVAKKNTLQFTGLEFFTGVGYFRDTVMYYGFYTNSTIQHGNSGASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFCWDFTVTHEKAVKLKQKNLSTEIRENLSELRQENSKLTFNQLLTRFSAYMVAWVVSTGVAIACCAAVYYLAEYNLEFLKTHSNPGAVLLLPFVVSCINLAVPCIYSMFRLVERYEMPRHEVYVLLIRNIFLKISIIGILCYYWLNTVALSGEECWETLIGQDIYRLLLMDFVFSLVNSFLGEFLRRIIGMQLITSLGLQEFDIARNVLELIYAQTLVWIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTGVLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSWIDTLSTRPGYLWVVWIYRNLIGSVHFFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKLQDMEKKANPSSLVLERREVEQQGFLHLGEHDGSLDLRSRRSVQEGNPRA", "length": 1006 }, "evidence": [ { "id": "F1MIU3", "url": "https://omabrowser.org/oma/group/F1MIU3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MIU3", "url": "https://www.uniprot.org/uniprotkb/F1MIU3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "mechanosensitive monoatomic ion channel activity", "id": "GO:0008381", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008381", "evidence": [ { "database": "UniProtKB", "id": "F1MIU3", "url": "https://www.uniprot.org/uniprotkb/F1MIU3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 161, "end_pos": 163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" }, { "start_pos": 36, "end_pos": 38, "annotation": "n_glycosylation_sequon" }, { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" }, { "start_pos": 497, "end_pos": 499, "annotation": "n_glycosylation_sequon" }, { "start_pos": 575, "end_pos": 577, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" }, { "start_pos": 637, "end_pos": 639, "annotation": "n_glycosylation_sequon" }, { "start_pos": 800, "end_pos": 802, "annotation": "n_glycosylation_sequon" }, { "start_pos": 873, "end_pos": 875, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MIU3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 993, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MIU3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MIU3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MIU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIU3" }, { "id": "PF07810", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07810" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TMC", "eco_id": "ECO_0000259", "start_pos": 711, "end_pos": 817, "start_aa": "Cys", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 134, "end_pos": 136 }, { "start_pos": 161, "end_pos": 163 }, { "start_pos": 23, "end_pos": 25 }, { "start_pos": 36, "end_pos": 38 }, { "start_pos": 407, "end_pos": 409 }, { "start_pos": 497, "end_pos": 499 }, { "start_pos": 575, "end_pos": 577 }, { "start_pos": 583, "end_pos": 585 }, { "start_pos": 637, "end_pos": 639 }, { "start_pos": 800, "end_pos": 802 }, { "start_pos": 873, "end_pos": 875 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { 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"count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPL4-1", "uniprot_ac": "E1BPL4", "uniprot_id": "E1BPL4_BOVIN", "mass": { "chemical_mass": 74916.0, "monoisotopic_mass": 74916.0 }, "refseq": {}, "gene_names": [ { "name": "KIRREL2", "type": "recommended", "evidence": [ { "id": "E1BPL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPL4" } ] } ], "protein_names": [ { "name": "Kin of IRRE-like protein 2", "type": "recommended", "evidence": [ { "id": "E1BPL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPL4/entry#names_and_taxonomy" } ] }, { "name": "Kin of irregular chiasm-like protein 2", "type": "synonym", "evidence": [ { "id": "E1BPL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPL4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May regulate basal insulin secretion.", "evidence": [ { "database": "UniProtKB", "id": "E1BPL4", "url": "https://www.uniprot.org/uniprotkb/E1BPL4#function" }, { "database": "UniProtKB", "id": "ARBA00053990", "url": "https://www.uniprot.org/uniprotkb/ARBA00053990#function" }, { "database": "UniProtKB", "id": "A0AAA9S5Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Q5#function" }, { "database": "UniProtKB", "id": "A0AAA9TJQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJQ3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPL4", "url": "https://www.uniprot.org/uniprotkb/E1BPL4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIRREL2", "url": "https://www.uniprot.org/uniprotkb/E1BPL4", "locus": { "chromosome": "18", "start_pos": 46565614, "end_pos": 46556439, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007826", "url": "https://www.ensembl.org/id/ENSBTAG00000007826" } ] } } ], "crossref": [ { "id": "E1BPL4", "url": "https://alphafold.ebi.ac.uk/entry/E1BPL4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007826", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007826", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051275", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051275", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BPL4", "url": "https://www.orthodb.org/?gene=E1BPL4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11640", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11640", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11640:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11640:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08205", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-373753", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373753", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S5Q5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Q5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5Q5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Q5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJQ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNG9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNG9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNG9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPL4", "url": "https://www.uniprot.org/uniprotkb/E1BPL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPL4-1", "url": "https://www.uniprot.org/uniprotkb/E1BPL4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TLRMLVPVLLVLSFCLRGRAGLAPHFLQQPEDQVVLLGDEARLPCALGDYRGLVQWTKDGLALGGERDLPGWSRYWISGNAASGQHDLHIRPVELEDQASYECQATQAGLRSRPAQLHVLVPPDPPQVLGGPSVSLVAGVPANLTCRSRGDAHPTPELLWFRDGIRLDGAIFRQTPLKEGTIGSVESILSLTPSSHDDGATLVCRARSQALPAGKDTAVTLSLQYPPVVTLSAEPQTVQEGEKVTFLCQATAQPPVTGYRWAKGGSPVLGARGPMLEIVADASFLTAPVSCEVSNAVGSANRSTALDVQFGPILQAKPKALSVDVGEDASFSCVWRGNPLPRVTWTRRGDAQVLASGPTLRLPAVGPEDAGDYVCRAEPGLSGRGGGSAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPTPEAVVWSWDEGFLTAGSRGRFLVETFPAPEGLKGQGPGLISVLHISGTQESDFHRGFNCTARNRLGEGGTQVSLGRRDLLPTVRIVAGVAAMAMTLLMIITGVALCCWRHGRASASFSKQKNLVRIPGSSDGSSSRGPEEETGISKDQGPIVHTDHSDLVLDEEGALETKDPTNGYYKVRGVSVSLSLGEAPGGGLFLPPSSPLGPPGTPTFYDFNPHLGMVPPCRLYRSRAGYLTTPHPRAFTSYIKPTSFGPPDLAPSTPPFPYAAFPTPSHPRLQTHV", "length": 707, "header": "tr|E1BPL4-1|E1BPL4_BOVIN Isoform 1 of Kin of IRRE-like protein 2 OS=Bos taurus OX=9913 GN=KIRREL2 PE=3 SV=4 CANONICAL=E1BPL4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S5Q5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5Q5/entry", "sequence": { "sequence": "TLRMLVPVLLVLSFCLRGRAGLAPHFLQQPEDQVVLLGDEARLPCALGDYRGLVQWTKDGLALGGERDLPGWSRYWISGNAASGQHDLHIRPVELEDQASYECQATQAGLRSRPAQLHVLVPPDPPQVLGGPSVSLVAGVPANLTCRSRGDAHPTPELLWFRDGIRLDGAIFRQTPLKEGTIGSVESILSLTPSSHDDGATLVCRARSQALPAGKDTAVTLSLQYPPVVTLSAEPQTVQEGEKVTFLCQATAQPPVTGYRWAKGGSPVLGARGPMLEIVADASFLTAPVSCEVSNAVGSANRSTALDVQFGPILQAKPKALSVDVGEDASFSCVWRGNPLPRVTWTRRGDAQVLASGPTLRLPAVGPEDAGDYVCRAEPGLSGRGGGSAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPTPEAVVWSWDEGFLTAGSRGRFLVETFPAPEGLKGQGPGLISVLHISGTQESDFHRGFNCTARNRLGEGGTQVSLGRRASASFSKQKNLVRIPGSSDGSSSRGPEEETGISKDQGPIVHTDHSDLVLDEEGALETKDPTNGYYKVRGVSVSLSLGEAPGGGLFLPPSSPLGPPGTPTFYDFNPHLGMVPPCRLYRSRAGYLTTPHPRAFTSYIKPTSFGPPDLAPSTPPFPYAAFPTPSHPRLQTHV", "length": 672, "header": "tr|A0AAA9S5Q5-1|E1BPL4_BOVIN Computationally mapped isoform of Kin of IRRE-like protein 2 OS=Bos taurus OX=9913 GN=KIRREL2 PE=3 SV=1 CANONICAL=E1BPL4-1" }, "locus": { "chromosome": "18", "start_pos": 46565015, "end_pos": 46556689, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134003.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134003.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080543.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080543.1" } ] } }, { "isoform_ac": "A0AAA9TJQ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJQ3/entry", "sequence": { "sequence": "TLRMLVPVLLVLSFCLRGRAGLAPHFLQQPEDQVVLLGDEARLPCALGDYRGLVQWTKDGLALGGERDLPGWSRYWISGNAASGQHDLHIRPVELEDQASYECQATQAGLRSRPAQLHVLVPPDPPQVLGGPSVSLVAGVPANLTCRSRGDAHPTPELLWFRDGIRLDGAIFRQTPLKEGTIGSVESILSLTPSSHDDGATLVCRARSQALPAGKDTAVTLSLQYPPVVTLSAEPQTVQEGEKVTFLCQATAQPPVTGYRWAKGGSPVLGARGPMLEIVADASFLTAPVSCEVSNAVGSANRSTALDVQFGPILQAKPKALSVDVGEDASFSCVWRGNPLPRVTWTRRGDAQVLASGPTLRLPAVGPEDAGDYVCRAEPGLSGRGGGSAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPTPEAVVWSWDEGFLTAGSRGRFLVETFPAPEGLKGQGPGLISVLHISGTQESDFHRGFNCTARNRLGEGGTQVSLGRRDLLPTVRIVAGVAAMAMTLLMIITGVALCCWRHGRASASFSKQKNLVRIPGSSDGSSSRGPEEETGISKDQGPIVHTDHSDLVLDEEGALETKDPTNGYYKVRGVSPPTSPDSCVTSLQLKSPGIFNLQ", "length": 632, "header": "tr|A0AAA9TJQ3-1|E1BPL4_BOVIN Computationally mapped isoform of Kin of IRRE-like protein 2 OS=Bos taurus OX=9913 GN=KIRREL2 PE=3 SV=1 CANONICAL=E1BPL4-1" }, "locus": { "chromosome": "18", "start_pos": 46565056, "end_pos": 46556689, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118331.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118331.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097379.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097379.1" } ] } }, { "isoform_ac": "A0AAA9TNG9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNG9/entry", "sequence": { "sequence": "TLRMLVPVLLVLSFCLRGRAGWSRYWISGNAASGQHDLHIRPVELEDQASYECQATQAGLRSRPAQLHVLVPPDPPQVLGGPSVSLVAGVPANLTCRSRGDAHPTPELLWFRDGIRLDGAIFRQTPLKEGTIGSVESILSLTPSSHDDGATLVCRARSQALPAGKDTAVTLSLQYPPVVTLSAEPQTVQEGEKVTFLCQATAQPPVTGYRWAKGGSPVLGARGPMLEIVADASFLTAPVSCEVSNAVGSANRSTALDVQFGPILQAKPKALSVDVGEDASFSCVWRGNPLPRVTWTRRGDAQVLASGPTLRLPAVGPEDAGDYVCRAEPGLSGRGGGSAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPTPEAVVWSWDEGFLTAGSRGRFLVETFPAPEGLKGQGPGLISVLHISGTQESDFHRGFNCTARNRLGEGGTQVSLGRRDLLPTVRIVAGVAAMAMTLLMIITGVALCCWRHGRASASFSKQKNLVRIPGSSDGSSSRGPEEETGISKDQGPIVHTDHSDLVLDEEGALETKDPTNGYYKVRGVSPPTSPDSCVTSLQLKSPGIFNLQ", "length": 582, "header": "tr|A0AAA9TNG9-1|E1BPL4_BOVIN Computationally mapped isoform of Kin of IRRE-like protein 2 OS=Bos taurus OX=9913 GN=KIRREL2 PE=3 SV=1 CANONICAL=E1BPL4-1" }, "locus": { "chromosome": "18", "start_pos": 46565056, "end_pos": 46556689, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134957.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134957.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098571.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098571.1" } ] } }, { "isoform_ac": "E1BPL4-1", "url": "https://www.uniprot.org/uniprotkb/E1BPL4/entry", "sequence": { "sequence": "TLRMLVPVLLVLSFCLRGRAGLAPHFLQQPEDQVVLLGDEARLPCALGDYRGLVQWTKDGLALGGERDLPGWSRYWISGNAASGQHDLHIRPVELEDQASYECQATQAGLRSRPAQLHVLVPPDPPQVLGGPSVSLVAGVPANLTCRSRGDAHPTPELLWFRDGIRLDGAIFRQTPLKEGTIGSVESILSLTPSSHDDGATLVCRARSQALPAGKDTAVTLSLQYPPVVTLSAEPQTVQEGEKVTFLCQATAQPPVTGYRWAKGGSPVLGARGPMLEIVADASFLTAPVSCEVSNAVGSANRSTALDVQFGPILQAKPKALSVDVGEDASFSCVWRGNPLPRVTWTRRGDAQVLASGPTLRLPAVGPEDAGDYVCRAEPGLSGRGGGSAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPTPEAVVWSWDEGFLTAGSRGRFLVETFPAPEGLKGQGPGLISVLHISGTQESDFHRGFNCTARNRLGEGGTQVSLGRRDLLPTVRIVAGVAAMAMTLLMIITGVALCCWRHGRASASFSKQKNLVRIPGSSDGSSSRGPEEETGISKDQGPIVHTDHSDLVLDEEGALETKDPTNGYYKVRGVSVSLSLGEAPGGGLFLPPSSPLGPPGTPTFYDFNPHLGMVPPCRLYRSRAGYLTTPHPRAFTSYIKPTSFGPPDLAPSTPPFPYAAFPTPSHPRLQTHV", "length": 707, "header": "tr|E1BPL4-1|E1BPL4_BOVIN Isoform 1 of Kin of IRRE-like protein 2 OS=Bos taurus OX=9913 GN=KIRREL2 PE=3 SV=4 CANONICAL=E1BPL4-1" }, "locus": { "chromosome": "18", "start_pos": 46565015, "end_pos": 46556689, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010297.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010297.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010297.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010297.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 697, "start_aa": "Thr", "end_pos": 697, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr697", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-373753", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-373753", "resource": "Reactome", "description": "Nephrin family interactions" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BPL4", "url": "https://www.uniprot.org/uniprotkb/E1BPL4" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BPL4", "url": "https://www.uniprot.org/uniprotkb/E1BPL4" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "E1BPL4", "url": "https://www.uniprot.org/uniprotkb/E1BPL4" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "E1BPL4", "url": "https://www.uniprot.org/uniprotkb/E1BPL4" } ], "pmid": "" }, { "name": "slit diaphragm", "id": "GO:0036057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036057", "evidence": [ { "database": "UniProtKB", "id": "E1BPL4", "url": "https://www.uniprot.org/uniprotkb/E1BPL4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BPL4", "url": "https://www.uniprot.org/uniprotkb/E1BPL4" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "E1BPL4", "url": "https://www.uniprot.org/uniprotkb/E1BPL4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "E1BPL4", "url": "https://www.uniprot.org/uniprotkb/E1BPL4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 301, "end_pos": 303, "annotation": "n_glycosylation_sequon" }, { "start_pos": 484, "end_pos": 486, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPL4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 707, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPL4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPL4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPL4" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 24, "end_pos": 118, "start_aa": "Pro", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 697 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 143, "end_pos": 145 }, { "start_pos": 301, "end_pos": 303 }, { "start_pos": 484, "end_pos": 486 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MFJ7-1", "uniprot_ac": "F1MFJ7", "uniprot_id": "F1MFJ7_BOVIN", "mass": { "chemical_mass": 57305.0, "monoisotopic_mass": 57305.0 }, "refseq": { "ac": "XP_024831487", "name": "sestrin-3 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831487" }, "gene_names": [ { "name": "SESN3", "type": "recommended", "evidence": [ { "id": "F1MFJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ] }, { "name": "SESN3", "type": "synonym", "evidence": [ { "id": "XP_024831487", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831487" } ] } ], "protein_names": [ { "name": "Sestrin 3", "type": "synonym", "evidence": [ { "id": "F1MFJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7/entry#names_and_taxonomy" } ] }, { "name": "sestrin-3 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024831487", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831487" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SESN3", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7", "locus": { "chromosome": "15", "start_pos": 15265116, "end_pos": 15192617, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004034", "url": "https://www.ensembl.org/id/ENSBTAG00000004034" } ] } } ], "crossref": [ { "id": "F1MFJ7", "url": "https://alphafold.ebi.ac.uk/entry/F1MFJ7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004034", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004034", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515914", "url": "https://www.ncbi.nlm.nih.gov/gene/515914", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006730", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006730", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515914", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515914", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CSYLINI", "url": "https://omabrowser.org/oma/group/CSYLINI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MFJ7", "url": "https://www.orthodb.org/?gene=F1MFJ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12474", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12474", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12474:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12474:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04636", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04636", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5628897", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024831487", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831487", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "67124", "url": "https://www.rhea-db.org/rhea/67124", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S637", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S637", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S637-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S637-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SC09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFJ7-1", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNRGGSSPSAAASYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPHRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLQYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLIPVNNFCVCDLANDNNIENASLTGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMTTRFEKEKKESLFVVSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRHLT", "length": 492, "header": "tr|F1MFJ7-1|F1MFJ7_BOVIN Isoform 1 of Sestrin 3 OS=Bos taurus OX=9913 GN=SESN3 PE=3 SV=3 CANONICAL=F1MFJ7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S637-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S637/entry", "sequence": { "sequence": "MSLHTQYLESFLRSQFYMLRMDGPLPLPHRHYIAIMKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLIPVNNFCVCDLANDNNIENASLTGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMTTRFEKEKKESLFVVSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRHLT", "length": 353, "header": "tr|A0AAA9S637-1|F1MFJ7_BOVIN Computationally mapped isoform of Sestrin 3 OS=Bos taurus OX=9913 GN=SESN3 PE=3 SV=1 CANONICAL=F1MFJ7-1" }, "locus": { "chromosome": "15", "start_pos": 15264112, "end_pos": 15247587, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129388.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129388.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078774.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078774.1" } ] } }, { "isoform_ac": "A0AAA9SC09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC09/entry", "sequence": { "sequence": "MNRGGSSPSAAASYLLCTNCRKVLRKVWCHSFPSNFRSSSSLLLCNSQPTSTNNLQIFFKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPHRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLQYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLIPVNNFCVCDLANDNNIENASLTGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMTTRFEKEKKESLFVVSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRHLT", "length": 526, "header": "tr|A0AAA9SC09-1|F1MFJ7_BOVIN Computationally mapped isoform of Sestrin 3 OS=Bos taurus OX=9913 GN=SESN3 PE=3 SV=1 CANONICAL=F1MFJ7-1" }, "locus": { "chromosome": "15", "start_pos": 15264112, "end_pos": 15192816, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088066.2", "url": "https://www.ensembl.org/id/ENSBTAT00000088066.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083639.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083639.1" } ] } }, { "isoform_ac": "F1MFJ7-1", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7/entry", "sequence": { "sequence": "MNRGGSSPSAAASYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPHRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLQYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLIPVNNFCVCDLANDNNIENASLTGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMTTRFEKEKKESLFVVSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRHLT", "length": 492, "header": "tr|F1MFJ7-1|F1MFJ7_BOVIN Isoform 1 of Sestrin 3 OS=Bos taurus OX=9913 GN=SESN3 PE=3 SV=3 CANONICAL=F1MFJ7-1" }, "locus": { "chromosome": "15", "start_pos": 15264112, "end_pos": 15192816, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005267.8", "url": "https://www.ensembl.org/id/ENSBTAT00000005267.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005267.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005267.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515914", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515914", "resource": "KEGG Pathway" }, { "id": "R-BTA-5628897", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5628897", "resource": "Reactome", "description": "TP53 Regulates Metabolic Genes" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A0W1-1", "protein_name": "Sestrin 3", "gene_name": "SESN3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNRGSSSPSAAANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPHRHYIAIMAAARHQCSYLINMHVDEFLKTGGNAEWLNGLEYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDLANDNNIENASLTGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMTTRFEKEKKESLFVVSGDTFHSFPHSDFEDDMVITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTTLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRHLT", "length": 492 }, "evidence": [ { "id": "F1MFJ7", "url": "https://omabrowser.org/oma/group/F1MFJ7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XTS4-1", "protein_name": "Sestrin 3", "gene_name": "SESN3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAHHQLWKNLYGNNSRYLISLFFAGVPVCMQRSFPLFSQQPSLEKRVQVSPPLTRGPSAFIPENEVMQANGLDERTNLLVEEYSTSGRLDNITQVMSIHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYIPQRLKNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPDTSNGVRLIAVNNFCVCDLANDNNIENASLTSSNFGIADSLSELEALMERMKRLQEDKEDEEASQEEMDTRFEKEKKESLLVISGAFDDEIVSTDVSRYVEDPGFGYKDFARRGEDHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTTLRRALFNYVHCMYGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRHLT", "length": 499 }, "evidence": [ { "id": "F1MFJ7", "url": "https://omabrowser.org/oma/group/F1MFJ7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LZQ4-1", "protein_name": "Sestrin 3", "gene_name": "Sesn3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNRGGSSASASANYLLCTNCRKVLRKDKRIRMSQPLTRGPSAFIPEKEVVQANTADERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPDRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLRNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVYGSGINPERDPGIANGFRLISVSSFCVCDLANDNSIGNASLAGGNFGIVDSLGELEALMERMKRLQEDREDEETTPEEMSTRFEKEKKESLFVVPGETFHSFPHSGFLCVAMDILEFTLWSRLASNSESSLPLPLIPSAEMQDFEDDMIVTADVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTTLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFTHSEKVHVNLLLMEARMQAELLYALRAITRHLT", "length": 529 }, "evidence": [ { "id": "F1MFJ7", "url": "https://omabrowser.org/oma/group/F1MFJ7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1R1P4-1", "protein_name": "Sestrin-3", "gene_name": "sesn3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNGTAGICNHCRNTIREKEKMSRHISTGPSSFIPENEIIGAMPLSDSTVMLLDEEFSGRMDNLTQVMGLHPHYLQAFLRCHYYLLRMDGPLPLHYRHYIAIMAAARHQCSTLVCHHVQEFEQIGVCSDWLRGLEFCPQRLRNLNEINKILAHRPWLITKQHIQALVKTGEHSWSLAELVHAVVLLAHFHALASFVFGSGVNPDPEVTEVNGVTGDLCPPVMKGLCTCHLTNSNQANGNPNTGSELEALMERMKRLLEEREDDDASEEEMFTRFEKEKKESLLVVSAGFDEEVVPPSPVARFVDDPSFGYQDFARHGEDNPPTFKAQDYSWEDHGFSLVNRLYSDIGHLLDDKFRTACDLTYYNMASHEGVDTSMLRRALFNYVHCMYGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTCRMYESYWHQFRHSEKVHVNLLLMEARMQAELLYALRAITHYMT", "length": 466 }, "evidence": [ { "id": "F1MFJ7", "url": "https://omabrowser.org/oma/group/F1MFJ7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P58005-1", "protein_name": "Sestrin-3", "gene_name": "SESN3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNRGGGSPSAAANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDLANDNNIENASLSGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMSTRFEKEKKESLFVVSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRHLT", "length": 492 }, "evidence": [ { "id": "F1MFJ7", "url": "https://omabrowser.org/oma/group/F1MFJ7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CYP7-1", "protein_name": "Sestrin-3", "gene_name": "Sesn3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNRGGSSASASANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTADERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPDRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLRNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPGIANGFRLISVSSFCVCDLANDNSIENTSLAGSNFGIVDSLGELEALMERMKRLQEDREDDETTREEMTTRFEKEKKESLFVVPGETLHAFPHSDFEDDVIVTADVSRYIEDPSFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTTLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFTHSEKVHVNLLLMEARMQAELLYALRAITRHLT", "length": 492 }, "evidence": [ { "id": "F1MFJ7", "url": "https://omabrowser.org/oma/group/F1MFJ7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ], "pmid": "" }, { "name": "TORC2 complex", "id": "GO:0031932", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031932", "evidence": [ { "database": "UniProtKB", "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ], "pmid": "" }, { "name": "GATOR2 complex", "id": "GO:0061700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061700", "evidence": [ { "database": "UniProtKB", "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "negative regulation of TORC1 signaling", "id": "GO:1904262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904262", "evidence": [ { "database": "UniProtKB", "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ], "pmid": "" }, { "name": "regulation of response to reactive oxygen species", "id": "GO:1901031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901031", "evidence": [ { "database": "UniProtKB", "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ], "pmid": "" }, { "name": "response to insulin", "id": "GO:0032868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "evidence": [ { "database": "UniProtKB", "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ], "pmid": "" }, { "name": "cellular response to glucose starvation", "id": "GO:0042149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042149", "evidence": [ { "database": "UniProtKB", "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ], "pmid": "" }, { "name": "cellular response to amino acid starvation", "id": "GO:0034198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", "evidence": [ { "database": "UniProtKB", "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ], "pmid": "" }, { "name": "cellular response to amino acid stimulus", "id": "GO:0071230", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071230", "evidence": [ { "database": "UniProtKB", "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ], "pmid": "" }, { "name": "TORC2 signaling", "id": "GO:0038203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038203", "evidence": [ { "database": "UniProtKB", "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ], "pmid": "" }, { "name": "regulation of insulin receptor signaling pathway", "id": "GO:0046626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046626", "evidence": [ { "database": "UniProtKB", "id": "F1MFJ7", "url": "https://www.uniprot.org/uniprotkb/F1MFJ7" } ], "pmid": "" }, { "name": 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] } ], "protein_names": [ { "name": "MRN complex interacting protein", "type": "synonym", "evidence": [ { "id": "F1MIA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIA0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MIA0", "url": "https://www.uniprot.org/uniprotkb/F1MIA0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MRNIP", "url": "https://www.uniprot.org/uniprotkb/F1MIA0", "locus": { "chromosome": "7", "start_pos": 1435525, "end_pos": 1417994, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015602", "url": "https://www.ensembl.org/id/ENSBTAG00000015602" } ] } } ], "crossref": [ { "id": "F1MIA0", "url": "https://alphafold.ebi.ac.uk/entry/F1MIA0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015602", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015602", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "614757", "url": "https://www.ncbi.nlm.nih.gov/gene/614757", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614757", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614757", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GHQQAEN", "url": "https://omabrowser.org/oma/group/GHQQAEN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MIA0", "url": "https://www.orthodb.org/?gene=F1MIA0", "database": 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taurus OX=9913 GN=MRNIP PE=4 SV=1 CANONICAL=F1MIA0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8E6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8E6/entry", "sequence": { "sequence": "MAPPQQARVLRCCCCSLFQAHQVKKSLKWTCKACGKKQSFLQAYGEGSGADCRRHVQKLNLLQGQISEMSLRSLGESISANEEENVGPWQAARASPQETLQPSKNRWLKYLERDSKELGLKGGGVCFNSQPSSETEKPDPPFSTGLPRKRKWNQSTVQPLCGPHVQDSRNCEVTLKSLKDRAGLAGKGRESSREDLDTTELVPRGEPPCPAQQVRTMSKWEQCLGNSSHLDTEPLTPLQRGLRPIQAAQAEQGAPRAQTPREGGLCRLPGARQSPQTTHTPMPGPKWLCGRIPEQSQGIGPWAEGVPLVKGMQARSSLMRLCDLFKTGEDFDDDL", "length": 335, "header": "tr|A0AAA9S8E6-1|F1MIA0_BOVIN Computationally mapped isoform of MRN complex interacting protein OS=Bos taurus OX=9913 GN=MRNIP PE=4 SV=1 CANONICAL=F1MIA0-1" }, "locus": { "chromosome": "7", "start_pos": 1435279, "end_pos": 1418041, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094156.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094156.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082319.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082319.1" } ] } }, { "isoform_ac": "A0ABI0P2Z9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2Z9/entry", "sequence": { "sequence": "MAPPQQARVLRCCCCSLFQAHQVKKSLKWTCKACGKKQSFLQETLQPSKNRWLKYLERDSKELGLKGGGVCFNSQPSSETEKPDPPFSTGLPRKRKWNQSTVQPLCGPHVQDSRNCEVTLKSLKDRAGLAGKGRESSREDLDTTELVPRGEPPCPAQQNGYKAILL", "length": 166, "header": "tr|A0ABI0P2Z9-1|A0ABI0P2Z9_BOVIN Computationally mapped isoform of MRN complex interacting protein OS=Bos taurus OX=9913 GN=MRNIP PE=4 SV=1 CANONICAL=F1MIA0-1" }, "locus": { "chromosome": "7", "start_pos": 1435546, "end_pos": 1418041, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000142761.1", "url": "https://www.ensembl.org/id/ENSBTAT00000142761.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107665.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107665.1" } ] } }, { "isoform_ac": "F1MIA0-1", "url": "https://www.uniprot.org/uniprotkb/F1MIA0/entry", "sequence": { "sequence": "MAPPQQARVLRCCCCSLFQAHQVKKSLKWTCKACGKKQSFLQAYGEGSGADCRRHVQKLNLLQGQISEMSLRSLGESISANEEENVGPWQAARASPQETLQPSKNRWLKYLERDSKELGLKGGGVCFNSQPSSETEKPDPPFSTGLPRKRKWNQSTVQPLCGPHVQDSRNCEVTLKSLKARPLHPTWGARSSPDCSTWDLPCISEELPPSFTQDRAGLAGKGRESSREDLDTTELVPRGEPPCPAQQVRTMSKWEQCLGNSSHLDTEPLTPLQRGLRPIQAAQAEQGAPRAQTPREGGLCRLPGARQSPQTTHTPMPGPKWLCGRIPEQSQGIGPWAEGVPLVKGMQARSSLMRLCDLFKTGEDFDDDL", "length": 369, "header": "tr|F1MIA0-1|F1MIA0_BOVIN Isoform 1 of MRN complex interacting protein OS=Bos taurus OX=9913 GN=MRNIP PE=4 SV=1 CANONICAL=F1MIA0-1" }, "locus": { "chromosome": "7", "start_pos": 1435279, "end_pos": 1418041, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020727.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020727.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020727.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020727.5" } ] } } ], "glycosylation": [], 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} ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MF76-1", "uniprot_ac": "F1MF76", "uniprot_id": "F1MF76_BOVIN", "mass": { "chemical_mass": 134069.0, "monoisotopic_mass": 134069.0 }, "refseq": { "ac": "XP_002698082", "name": "BOS complex subunit NOMO1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698082" }, "gene_names": [ { "name": "LOC515570", "type": "recommended", "evidence": [ { "id": "F1MF76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF76" } ] }, { "name": "LOC515570", "type": "synonym", "evidence": [ { "id": "XP_002698082", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698082" } ] } ], "protein_names": [ { "name": "BOS complex subunit NOMO1", "type": "synonym", "evidence": [ { "id": "XP_002698082", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698082" } ] }, { "name": "Uncharacterized protein", "type": "synonym", "evidence": [ { "id": "F1MF76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF76/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions.", "evidence": [ { "database": "UniProtKB", "id": "F1MF76", "url": "https://www.uniprot.org/uniprotkb/F1MF76#function" }, { "database": "UniProtKB", "id": "ARBA00056484", "url": "https://www.uniprot.org/uniprotkb/ARBA00056484#function" }, { "database": "UniProtKB", "id": "A0AAA9SCA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCA4#function" }, { "database": "UniProtKB", "id": "A0AAA9SDD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD6#function" }, { "database": "UniProtKB", "id": "A0AAA9T2E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E5#function" }, { "database": "UniProtKB", "id": "A0AAA9TTD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTD1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MF76", "url": "https://www.uniprot.org/uniprotkb/F1MF76" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC515570", "url": "https://www.uniprot.org/uniprotkb/F1MF76", "locus": {} } ], "crossref": [ { "id": "F1MF76", "url": "https://alphafold.ebi.ac.uk/entry/F1MF76", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017759", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017759", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515570", "url": "https://www.ncbi.nlm.nih.gov/gene/515570", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013784", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013784", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056189", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056189", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056191", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056191", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056319", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056319", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515570", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515570", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FVFKGFG", "url": "https://omabrowser.org/oma/group/FVFKGFG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MF76", "url": "https://www.orthodb.org/?gene=F1MF76", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23303", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23303", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23303:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23303:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17802", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17802", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22898", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22898", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22902", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22902", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22904", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22904", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23141", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23141", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23192", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23192", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23194", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23194", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23660", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23660", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002698082", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698082", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SCA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDD6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SDD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2E5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2E5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTD1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTD1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF76", "url": "https://www.uniprot.org/uniprotkb/F1MF76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF76-1", "url": "https://www.uniprot.org/uniprotkb/F1MF76-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGRRGMGPPEPAVVAATVLLLLSRVEPACGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELYVDGVSDICTKGGDINFVFTGFSVSGKVLSKGQPLGPAGVQVSLRNTGTDAKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWPLKEASTTVRVTNSNANAAGPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNLSPVPGFQPQDESLEYLCHAVSKEDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGEGVPDAVVTLNSQIKVRTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIIATGFSVCGQISITRFPDTVKQMGKYKVVLASQDKDKSLVTVETDAQGSFCFKAKPGTYKVQVMVPEAETRAGLTLKPQTLLLAVTDRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLHLSGKVNSMTFMFDNVLPGKYKISILHEDWCWKNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAITLEFYQDGNGPENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIESRRQERERSGGEAGGEGRTKPPVQEMVDELQGPFFYDFSYWARSGEKITVTPSSKELLFYPPSMEATVSGESCPGKLIEIQGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVSSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGVFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTAYSCYGTVSSLNGEPEQGVAVEAVGQSDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERALPHHRVIVVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKSDNLDNPIQTVSLGQSLFFHFPPLLRDGQNYVVLLDSTLPRSQYDFVLPQVSFTAAGYHKHITLVFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVRALGQTASDNSGPEDAKRQAKKQKTRRT", "length": 1222, "header": "tr|F1MF76-1|F1MF76_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC515570 PE=4 SV=2 CANONICAL=F1MF76-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCA4/entry", "sequence": { "sequence": "MRGRRGMGPPEPAVVAATVLLLLSRVEPACGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELYVDGVSDICTKGGDINFVFTGFSVSGKVLSKGQPLGPAGVQVSLRNTGTDAKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWPLKEASTTVRVTNSNANAAGPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNLSPVPGFQPQDESLEYLCHAVSKEDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGEGVPDAVVTLNSQIKVRTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIIATGFSVCGQISITRFPDTVKQMGKYKVVLASQDKDKSLVTVETDAQGSFCFKAKPGTYKVQVMVPEAETRAGLTLKPQTLLLAVTDRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLHLSGKVNSMTFMFDNVLPGKYKISILHEDWCWKNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAITLEFYQDGNGPENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIESRRQERERSGGEAGGEGRTKPPVQEMVDELQGPFFYDFSYWARSGEKITVTPSSKELLFYPPSMEATVSGESCPGKLIEIQGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVSSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGVFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTAYSCYGTVSSLNGEPEQGVAVEAVGQSDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERALPHHRVIVVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKSDNLDNPIQTVSLGQSLFFHFPPLLRDGQNYVVLLDSTLPRSQYDFVLPQVSFTAAGYHKHITLVFNPTLIPLLLQLTSRLQGVRALGQTASDNSGPEDAKRQAKKQKTRRT", "length": 1191, "header": "tr|A0AAA9SCA4-1|F1MF76_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC515570 PE=4 SV=1 CANONICAL=F1MF76-1" }, "locus": { "chromosome": "25", "start_pos": 14612829, "end_pos": 14556878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100780.2", "url": "https://www.ensembl.org/id/ENSBTAT00000100780.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081158.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081158.1" } ] } }, { "isoform_ac": "A0AAA9SDD6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDD6/entry", "sequence": { "sequence": "MRGRRGMGPPEPAVVAATVLLLLSRVEPACGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELYVDGVSDICTKGGDINFVFTGFSVSGKASTTVRVTNSNANAAGPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNLSPVPGFQPQDESLEYLCHAVSKEDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGEGVPDAVVTLNSQIKVRTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIIATGFSVCGQISITRFPDTVKQMGKYKVVLASQDKDKSLVTVETDAQGSFCFKAKPGTYKVQVMVPEAETRAGLTLKPQTLLLAVTDRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLHLSGKVNSMTFMFDNVLPGKYKISILHEDWCWKNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAITLEFYQDGNGPENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIESRRQERERSGGEAGGEGRTKPPVQEMVDELQGPFFYDFSYWARSGEKITVTPSSKELLFYPPSMEATVSGESCPGKLIEIQGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVSSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGVFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTAYSCYGTVSSLNGEPEQGVAVEAVGQSDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERALPHHRVIVVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKSDNLDNPIQTVSLGQSLFFHFPPLLRDGQNYVVLLDSTLPRSQYDFVLPQVSFTAAGYHKHITLVFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVRALGQTASDNSGPEDAKRQAKKQKTRRT", "length": 1162, "header": "tr|A0AAA9SDD6-1|F1MF76_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC515570 PE=4 SV=1 CANONICAL=F1MF76-1" }, "locus": { "chromosome": "25", "start_pos": 14612829, "end_pos": 14556878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104150.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104150.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083422.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083422.1" } ] } }, { "isoform_ac": "A0AAA9T2E5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2E5/entry", "sequence": { "sequence": "MRGRRGMGPPEPAVVAATVLLLLSRVEPACGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELYVDGVSDICTKGGDINFVFTGFSVSGKVLSKGQPLGPAGVQVSLRNTGTDAKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWPLKEASTTVRVTNSNANAAGPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNLSPVPGFQPQDESLEYLCHAVSKEDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGEGVPDAVVTLNSQIKVRTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIIATGFSVCGQISITRFPDTVKQMGKYKVVLASQDKDKSLVTVETDAQGSFCFKAKPGTYKVQVMVPEAETRAGLTLKPQTLLLAVTDRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLHLSGKVNSMTFMFDNVLPGKYKISILHEDWCWKNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAITLEFYQDGNGPENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIESRRQERERSGGEAGGEGRTKPPVQEMVDELQGPFFYDFSYWARSGEKITVTPSSKELLFYPPSMEATVSGESCPGKLIEIQGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVSSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGVFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTAYSCYGTVSSLNGEPEQGVAVEAVGQSDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERALPHHRVIVVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKSDNLDNPIQTVSLGQSLFFHFPPLLRDGQRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVRALGQTASDNSGPEDAKRQAKKQKTRRT", "length": 1182, "header": "tr|A0AAA9T2E5-1|F1MF76_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC515570 PE=4 SV=1 CANONICAL=F1MF76-1" }, "locus": { "chromosome": "25", "start_pos": 14612829, "end_pos": 14556878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109584.2", "url": "https://www.ensembl.org/id/ENSBTAT00000109584.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090602.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090602.1" } ] } }, { "isoform_ac": "A0AAA9TTD1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTD1/entry", "sequence": { "sequence": "MRGRRGMGPPEPAVVAATVLLLLSRVEPACGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELYVDGVSDICTKGGDINFVFTGFSVSGKVLSKGQPLGPAGVQVSLRNTGTDAKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWPLKEASTTVRVTNSNANAAGPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGEGVPDAVVTLNSQIKVRTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIIATGFSVCGQISITRFPDTVKQMGKYKVVLASQDKDKSLVTVETDAQGSFCFKAKPGTYKVQVMVPEAETRAGLTLKPQTLLLAVTDRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLHLSGKVNSMTFMFDNVLPGKYKISILHEDWCWKNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAITLEFYQDGNGPENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIESRRQERERSGGEAGGEGRTKPPVQEMVDELQGPFFYDFSYWARSGEKITVTPSSKELLFYPPSMEATVSGESCPGKLIEIQGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVSSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGVFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTAYSCYGTVSSLNGEPEQGVAVEAVGQSDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERALPHHRVIVVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKSDNLDNPIQTVSLGQSLFFHFPPLLRDGQNYVVLLDSTLPRSQYDFVLPQVSFTAAGYHKHITLVFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVRALGQTASDNSGPEDAKRQAKKQKTRRT", "length": 1176, "header": "tr|A0AAA9TTD1-1|F1MF76_BOVIN Computationally mapped isoform of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC515570 PE=4 SV=1 CANONICAL=F1MF76-1" }, "locus": { "chromosome": "25", "start_pos": 14612829, "end_pos": 14556878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133049.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133049.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100605.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100605.1" } ] } }, { "isoform_ac": "F1MF76-1", "url": "https://www.uniprot.org/uniprotkb/F1MF76/entry", "sequence": { "sequence": "MRGRRGMGPPEPAVVAATVLLLLSRVEPACGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELYVDGVSDICTKGGDINFVFTGFSVSGKVLSKGQPLGPAGVQVSLRNTGTDAKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWPLKEASTTVRVTNSNANAAGPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNLSPVPGFQPQDESLEYLCHAVSKEDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGEGVPDAVVTLNSQIKVRTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIIATGFSVCGQISITRFPDTVKQMGKYKVVLASQDKDKSLVTVETDAQGSFCFKAKPGTYKVQVMVPEAETRAGLTLKPQTLLLAVTDRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLHLSGKVNSMTFMFDNVLPGKYKISILHEDWCWKNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAITLEFYQDGNGPENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIESRRQERERSGGEAGGEGRTKPPVQEMVDELQGPFFYDFSYWARSGEKITVTPSSKELLFYPPSMEATVSGESCPGKLIEIQGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVSSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGVFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTAYSCYGTVSSLNGEPEQGVAVEAVGQSDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERALPHHRVIVVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKSDNLDNPIQTVSLGQSLFFHFPPLLRDGQNYVVLLDSTLPRSQYDFVLPQVSFTAAGYHKHITLVFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVRALGQTASDNSGPEDAKRQAKKQKTRRT", "length": 1222, "header": "tr|F1MF76-1|F1MF76_BOVIN Isoform 1 of Uncharacterized protein OS=Bos taurus OX=9913 GN=LOC515570 PE=4 SV=2 CANONICAL=F1MF76-1" }, "locus": { "chromosome": "25", "start_pos": 14612829, "end_pos": 14556878, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046252.6", "url": "https://www.ensembl.org/id/ENSBTAT00000046252.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043570.3", "url": "https://www.ensembl.org/id/ENSBTAP00000043570.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 637, "start_aa": "Thr", "end_pos": 637, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr637", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:515570", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515570", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1I9LSH2-1", "protein_name": "Carbohydrate-binding-like fold", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAASRKICHSLIVFLIAISTVYGVSADSIKGCGGFVEASSSLVRSRKGSDGKLDFSHITVELQTVDGLVKDSTQCAPNGYYFIPVYDKGSFILKINGPDGWSWNPDKVTVVVDDSSCNNNDDINFHFTGFTLSGKVLGAVGGESCLIKNGGPADVNVELLSSDGSEDPVASVLTSSDGSYLFKNIIPGTYNIRASHPELQVEVRGSTEVELGFANGMVDDIFFVLGYDLKGSVVAQGNPILGVHIYLHSDDVSMVDCPQGSGDAAGERKSLCHAVSDAEGIFSFKSIPCGKYELVPHYKGENTVFDVSPPVMPVSVEHQHVTVPQKFQVTGFSIGGRVVDGNSVGVEGVKILVDGSLRSVTDKEGYYKLDQVTSNQYTIDAVKEHYKFDKLKKFMVLPNMASLPDINAVSYDICGVVRMFGSRHKAKVALTHGPTNVKPQMKLTDETGAFCFEVPPGEYRLSALAATPKGASELLFLPAYVDVAVKSPLLNIEFSQARVNVHGSVTCKEKCGPSVSVVLVGAAGDRDKKTVVLTDESSQFLFSDILPGKYRVEVKSISPEAASDEDSWCWDRSSIDVNVGTEDIKGIEFVQKGYWINIISTHEVDARIAHPDGSPTSLKIKKGSQKICIESPGGHELQLSDSCMSFGSNSIKIDVSNPQPIHLKAEKYLLKGLINVESSSTIESELQENFIVDIQDKKGNVINTIAAKLASDGSGVYEYYTWASLGEKISFVPQDSRGNVEKKMLFYPKEIHAVVSKDGCQASVSPFTGRLGLYIQGSVSPPLPGVNIKIFAAKDSLISSLKKGEIAIETSTLSAGSFVAGPLYDDIPYATEASKPGYHIKRLGPYSFSCQKLGQISVRVNSKDNAETSIPPLLLSLSGDHGYRNNSISGAGGLFVFDSLFPGNFYLRPLLKEYSFKPSTLAIELNSGESSEAVFEATRVAYSAMGRVALLSGQPQEGVAIEARSDSKGYYEETTSDINGNYRLRGLHPDTAYVIKVSKKIGSANNQIERASPESVSLQIGYEDINGLDFLVFEQPETTILTCHVEGKQNEDLNSNLLVEIKSAIDKSKIENVFPLPLSNFFQVKGLPKGKHLVQLKSSRPLISHKVESEIIEVDFETNAQIHIGPLRYSIVADHQSQEVTPAAILPLVIGVSAIALFLSIPRLKDIYQATVGISSPGFTTSAKREPRKAVARKKTF", "length": 1197 }, "evidence": [ { "id": "F1MF76", "url": "https://omabrowser.org/oma/group/F1MF76/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "A0A8V0ZFY8-1", "protein_name": "Prealbumin-like fold domain-containing protein", "gene_name": "PM5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRAWVAVLGCALCCALVRGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTSVDIHVDGINDICTKGGDINFVFTGFSVNGKVLSKGQSLGPAGVQVVLRNAGSDVNLQATVTQPGGKFAFFKVLPGEYEIFASHPTWMLKESNTVVRVTSSNAYAASPLIVAGYNVSGSVRSDGEPMKGVMFLLFSSSVTKEDVVGCNVSPVDGFQSRDESLSYLCNVVSKEDGSFSFLSLPSGKYTVIPFYRGERITFDVAPSRLDFFVEHDSLQIEPVFHVMGFSVTGRVLNGPEGEGVADATVTLNNQIKVKTKADGSFRLENITTGTYTIHARKEHLFFDTITVKIAPNTPQLADIIATGFSVCGQISVIRLPDAVKQINKYKVTMVSQDKDKASMVTTETDPHGAFCFKAKSGAYIVKVVIPEAETRAGLALKPKVFPVTVTDRPVMDVTFSQFLASVSGKISCLDACGDLVVMLQSVSRQGEKRNLQLSGSTDSVAFMFENVLPGKYKVSIVHEDWCWKNKSLEVEIMEEDVSGVEFRQTGYMLRCSLSHAITLEFYQDGNGPENVGVYNLSKGVNRFCLSKPGVYEVTPRSCHQFEHEYYTYDTSSPSILTLTAVRHHVLGTIVTDKLMDVTITIKSSIDSEPALVLGPLKSVQELRREQQLAEIETRRQEREKKGQEEEGTKPPVQEMVEELQGPFLYEFSYWARSGEKITVTPSSKELLFYPPYVETVVSGESCPGKLIEIHGKAGLFMEGQIHPELEGVEIVIGEKGAPSPLITVFTDDKGAYSVGPLHSDLEYTVTAQKEGFVLTAVEGTVGDFKAFALAGVTFEIKSEDDQALAGVLLSLSGGVFRSNLLTQDNGMLTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKIWITGYRTAYSCYGTVSSLNGEPEQGVSVEAVGQEGCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERALPQHRAIEVGNSDIDDVNIIAFRQINQFDLSGNVITSSEYLSTLCVKLYKSENLDNPIHTVNLGQSLFFHFPPLLRDGENYMVLLDSTLSKSQYDYILPQVSFTAIGYHKHITLVFSPTRKLPEQDIAQGSYIALPLTLLLLLAGYNHDKLIPLLLQLTTRLQGVRALGQTGSDTGGPEDAKRQTKKQKTRRT", "length": 1208 }, "evidence": [ { "id": "F1MF76", "url": "https://omabrowser.org/oma/group/F1MF76/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A1Z843-1", "protein_name": "Nodal modulator 3", "gene_name": "Dmel\\CG1371", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRFFSGVFVILLIKLFQNANAGEVEVVGCGGFIKSHAEIDFSRVEIKLLTKQGSLKDKTDCSPSNGYYFLPIYDKGDYLLSISPPPGWSFEPEQVELNFDGKTDVCSQGRDVNFVFKGFGITGQVALAAGGGARGVDVELRSEQGEVRRTKSDANGVFSFTPIIPGNYVVKASHARWHFSKAEHKVVVVSGNTELPANSLVVSGFDVVGRFDSSSPLPGNLGVALYKKKGQSLVPKCETSSPAPPNSVNSAYESASSCFSQLDKSGEYIFKNVPSGKYLLQAINLDSKLKLHLSPELLELEVGKDTLQIKDEFKITGFTVSGRVLTSAGGEPLKSAVIKVNGKKVAETDAQGSYTLENLKAGTVNIEVESSQLQFSPLQVKAQINTASLPTIVPSAYEVCGKVVSPKSHNVGLTKIGSTFHSSASTNAETGNWCAFLPVGKYTIEVLTTDADKAAGVQFFPVQQQTEVRDAPVNGITFSQLRAKIRGELQCLPDATATCTSAEVTLQALDATGQPTENKWKARAHRGKYVFKDMLPGPYELTIPQGNLCYESTRVFLNVASAEEDAPPFVHKGYEVSIISSHRALMKYTHVTGPSEPKAPTESLKIASGVNTFCVKKYGSYDFKLEGCHTYDESLPSKFITPEPDQLQTLIINAVAHKTGVRVLSTEPTADSIKLVLESESLGQEVITPVAESHKVDGKFAYRYDTYLKPEQVLRITPVSDVLLFAPQQHEIVGSSDCVDIAFNFVATRGLILRGKVVPAIKDAKITLSFPDQPELESLEVLTSVTGEFKFGPIEESLAFDLKAEKESYVFSDYNRQTASFSAHKLCEISVVVKDEAGQTLGGVLLSLSGGESYRKNLVTGDNGAINFHSLSPSQYYLRPMMKEYKFEPNSKMIDIKDGETVSVTLVGKRFAYSIFGTVSSLNGDPFAGVNVQATADNSCPQQPEEATSEANGQYRIRGLQPGCSYSVRVVPDKEIVERSIPAQHTVKVANEDVRDINLVAISPLKIVDITARVTATLNEHYKTLRIVMYRKGNSDSPVFSQRVGTPVNPKARLNPGITVFFPRIPLDGKSYVVELQSTLSDKTYTYKLPSTTFVADRGSVFVELEFKPEVRAAEADLNQNSISALVLIALVAIAFFKQDLATSFLSFVWSKLNDVAADLAQRQKSKTQVRKNEPINQREIEQMADQINAIKKKKTKKI", "length": 1199 }, "evidence": [ { "id": "F1MF76", "url": "https://omabrowser.org/oma/group/F1MF76/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "D3ZSA9-1", "protein_name": "Nodal modulator 1", "gene_name": "Nomo1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRAGRCAAVLLLLLLSGPGRAIGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTNVELHVDGVSDVCTRGGDINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRSTGADSKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAAGPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVNKEDVLGCNVSPVSGFQPPDESLVYLCYAVSKEDGSFSFYSLPSGGYTVVPFYRGERITFDVAPSRLDFTVEHDSLRIEPVFHVMGFSVTGRVLNGPDGEGVPEAVVTLNNQIKVRTKADGSFRLENITTGTYTIHAQKEHLYFDMVTIKIAPNTPQLADLIATGFSICGQISIIRSPDTIKQMNKYKVVLSSQDKDKALVTVETDAHGSFCFKAKPGIYKVQVVVPEAETRAGLMLKPQTFPITVTNKPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLQLSGKVNSMTFTFDKVLPGKYKISIMHEDWCWRNKSLEVEVLEDDVSAVEFRQTGYMLRCALSHAITLEFHQDGNGPENVGIYNLSRGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTIITDKMMDVTVTIKSSIDSEPALVLGPLKSAQELRREQQLAEIETRRQEREKNGKEEGEEGRARPPGQEMVDELQGPFSYDFSYWARCGEKITVTPSSKELLFYPPSMEATVSGESCPGKLIEIHGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVTSQKEGFVLTAVEGTVGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGVFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLRITITGFRTAYSCYGTVSSLNGEPEQGVAVEAVGQKDCSIYGEDTVTDEEGKFRLRGLLPGCMYHVQLKAEGNDHIERALPHHRVIEVGNNDVDDVNIIVFRQINQFDLSGNVITSSEYLSTLWVKLYKSESLDNPIQTVSLGQSLFFHFPPLLRDGENYVVLLDSTLPRSQYDYVLPQVSFAAVGYHKHITLVFSPTWSMSENLQGVTAIPLQRKLPEQDIAQGSYIALPLTLLLLLAGYNHDKLIPLLLQLTSRLQGVRALGQAASDSSGPEDMKRQTKKQKTRRT", "length": 1230 }, "evidence": [ { "id": "F1MF76", "url": "https://omabrowser.org/oma/group/F1MF76/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P69849-1", "protein_name": "BOS complex subunit NOMO3", "gene_name": "NOMO3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLVGQGAGPLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELHVDGVSDICTKGGDINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNVSPVPGFQPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEAVVTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIVATGFSVCGQISIIRFPDTVKQMNKYKVVLSSQDKDKSLVTVETDAHGSFCFKANPGTYKVQVMVPEAETRAGLTLKPQTFPLTVTDRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLQLSGKVNAMTFTFDNVLPGKYKISIMHEDWCWKNKSLEVEVLEDDVSAVEFRQTGYMLRCSLSHAITLEFYQDGNGRENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIEARRQEREKNGNEEGEERMTKPPVQEMVDELQGPFSYDFSYWARSGEKITVTPSSKELLFYPPSMEAVVSGESCPGKLIEIHGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVTSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGLFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTAYSCYGTVSSLNGEPEQGVAMEAVGQNDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERALPHHRVIEVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKSENLDNPIQTVSLGQSLFFHFPPLLRDGENYVVLLDSTLPRSQYDYILPQVSFTAVGYHKHITLIFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVGALGQAASDNSGPEDAKRQAKKQKTRRT", "length": 1222 }, "evidence": [ { "id": "F1MF76", "url": "https://omabrowser.org/oma/group/F1MF76/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6GQT9-1", "protein_name": "BOS complex subunit NOMO1", "gene_name": "Nomo1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRAGRCAAALLLLLLSGAGRAIGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTNVELRVDGVSDICTKGGDINFLFTGFSVNGKVLSKGQPLGPAGVQVSLRSTGADSKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAAGPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVNKEDVLGCNVSPVSGFQPPDESLVYLCYAVSKEDGSFSFYSLPSGGYTVVPFYRGERITFDVAPSRLDFTVEHDSLRIEPVFHVMGFSVTGRVLNGPDGEGVPEAVVTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFEMVTIKIAPNTPQLADLIATGFSICGQIAIVRSPDTIKQMSKYRVVLSSQDKDKALLTVDSDAHGSFCFKAKPGAYKVQVVVPEAETRAGLMLKPQVFPLTVTNRPVMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLQLSGKVNSMTFTFDKVLPGRYKISIMHEDWCWRNKSLEVEVLEDDVSAVEFRQTGYMLRCALSHAITLEFHQDGNGPENVGIYNLSRGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTIITDKMMDVTVTIKSSIDSEPALVLGPLKSAQELRREQQLAEIETRRQEREKNGKEEGEEGRARPPGQEMVDELQGPFSYDFSYWARSGEKITVTPSSKELLFYPPSMEATVSGESCPGKLIEIHGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVNSQKEGYVLTAVEGTVGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGVFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLRITITGFRTAYSCYGTVSSLNGEPEQGVAVEAVGQKDCSIYGEDTVTDEEGKFRLRGLLPGCMYHVQLKAEGNDHIERALPHHRVIEVGNNDVDDVNIIVFRQINQFDLSGNVITSSEYLSTLWVKLYKSESLDNPIQTVSLGQSLFFHFPPLLRDGENYVVLLDTTLPRSQYDYVLPQVSFTAVGYHKHITLVFSPTRKLPEQDIAQGSYIALPLTLLLLLAGYNHDKLIPLLLQLTSRLQGVRALGQAASDSSGPEDMKRQTKKQKTRRT", 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"IPR017983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050332", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050332", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SKSQHPW", "url": "https://omabrowser.org/oma/group/SKSQHPW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45620", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45620", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45620:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45620:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02793", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02793", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-420092", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420092", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SCE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SCE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6P7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6P7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF07", "url": "https://www.uniprot.org/uniprotkb/F1MF07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF07-1", "url": "https://www.uniprot.org/uniprotkb/F1MF07-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPTCPPPARWFCLLTGALVCVLGPAGGWAVGLQQEECDYLRMIAVQHEQCLEEAQLENETAGCGKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTEAGWTPLEPGPYPVACGLDDNSSSLDEQQTMFYSSVKTGYTIGYSLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFNSGETDHCSKGSVGCKAAVVLFQYCVMANFFWLLVEGLYLHTLLAVSFFSERKYFWGYIFIGWGVPSTFTLVWTIIRIHFEDYGCWDTINSSLWWIIKAPILASILVNFILFIRIIGILVQKLRPDVGKSDSSPYSRLAKSTLLLIPLFGVHYIMFAFFPDNFKAEVKLVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWDPKYQHPSAGSNGATCSTQVSMLTRVSPGAGRSSSFQAEVSLV", "length": 457, "header": "tr|F1MF07-1|F1MF07_BOVIN Isoform 1 of Vasoactive intestinal polypeptide receptor 1 OS=Bos taurus OX=9913 GN=VIPR1 PE=3 SV=3 CANONICAL=F1MF07-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SCE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCE2/entry", "sequence": { "sequence": "MLADRRPSLRPRPRGCGKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTEAGWTPLEPGPYPVACGLDDNSSSLDEQTMFYSSVKTGYTIGYSLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFNSGETDHCSKGSVGCKAAVVLFQYCVMANFFWLLVEGLYLHTLLAVSFFSERKYFWGYIFIGWGVPSTFTLVWTIIRIHFEDYGCWDTINSSLWWIIKAPILASILVNFILFIRIIGILVQKLRPDVGKSDSSPYSRLAKSTLLLIPLFGVHYIMFAFFPDNFKAEVKLVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWDPKYQHPSAGSNGATCSTQVSMLTRVSPGAGRSSSFQAEVSLV", "length": 408, "header": "tr|A0AAA9SCE2-1|F1MF07_BOVIN Computationally mapped isoform of Vasoactive intestinal polypeptide receptor 1 OS=Bos taurus OX=9913 GN=VIPR1 PE=3 SV=2 CANONICAL=F1MF07-1" }, "locus": { "chromosome": "22", "start_pos": 14688737, "end_pos": 14658245, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097908.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097908.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083057.2", "url": "https://www.ensembl.org/id/ENSBTAP00000083057.2" } ] } }, { "isoform_ac": "A0AAA9T6P7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6P7/entry", "sequence": { "sequence": "MTIHRVWMRWAARQPWSYSSTVSWPTSSGCWWRASTCTPCSPSPSSPSGSTSGGVPSTFTLVWTIIRIHFEDYGCWDTINSSLWWIIKAPILASILVNFILFIRIIGILVQKLRPDVGKSDSSPYSRLAKSTLLLIPLFGVHYIMFAFFPDNFKAEVKLVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWDPKYQHPSAGSNGATCSTQVSMLTRVSPGAGRSSSFQAEVSLV", "length": 246, "header": "tr|A0AAA9T6P7-1|F1MF07_BOVIN Computationally mapped isoform of Vasoactive intestinal polypeptide receptor 1 OS=Bos taurus OX=9913 GN=VIPR1 PE=3 SV=1 CANONICAL=F1MF07-1" }, "locus": { "chromosome": "22", "start_pos": 14688737, "end_pos": 14678527, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105463.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105463.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093567.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093567.1" } ] } }, { "isoform_ac": "F1MF07-1", "url": "https://www.uniprot.org/uniprotkb/F1MF07/entry", "sequence": { "sequence": "MRPTCPPPARWFCLLTGALVCVLGPAGGWAVGLQQEECDYLRMIAVQHEQCLEEAQLENETAGCGKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTEAGWTPLEPGPYPVACGLDDNSSSLDEQQTMFYSSVKTGYTIGYSLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFNSGETDHCSKGSVGCKAAVVLFQYCVMANFFWLLVEGLYLHTLLAVSFFSERKYFWGYIFIGWGVPSTFTLVWTIIRIHFEDYGCWDTINSSLWWIIKAPILASILVNFILFIRIIGILVQKLRPDVGKSDSSPYSRLAKSTLLLIPLFGVHYIMFAFFPDNFKAEVKLVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWDPKYQHPSAGSNGATCSTQVSMLTRVSPGAGRSSSFQAEVSLV", "length": 457, "header": "tr|F1MF07-1|F1MF07_BOVIN Isoform 1 of Vasoactive intestinal polypeptide receptor 1 OS=Bos taurus OX=9913 GN=VIPR1 PE=3 SV=3 CANONICAL=F1MF07-1" }, "locus": { "chromosome": "22", "start_pos": 14688737, "end_pos": 14658210, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008625.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008625.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008625.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008625.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" }, { "id": "R-BTA-420092", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-420092", "resource": "Reactome", "description": "Glucagon-type ligand receptors" } ], "orthologs": [ { "uniprot_canonical_ac": "P30083-1", "protein_name": "Vasoactive intestinal polypeptide receptor 1", "gene_name": "Vipr1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRPPSPPHVRWLCVLAGALACALRPAGSQAASPQHECEYLQLIEIQRQQCLEEAQLENETTGCSKMWDNLTCWPTTPRGQAVVLDCPLIFQLFAPIHGYNISRSCTEEGWSQLEPGPYHIACGLNDRASSLDEQQQTKFYNTVKTGYTIGYSLSLASLLVAMAILSLFRKLHCTRNYIHMHLFMSFILRATAVFIKDMALFNSGEIDHCSEASVGCKAAVVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSVFITIWTVVRIYFEDFGCWDTIINSSLWWIIKAPILLSILVNFVLFICIIRILVQKLRPPDIGKNDSSPYSRLAKSTLLLIPLFGIHYVMFAFFPDNFKAQVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWSSKSQHPWGGSNGATCSTQVSMLTRVSPSARRSSSFQAEVSLV", "length": 459 }, "evidence": [ { "id": "F1MF07", "url": "https://omabrowser.org/oma/group/F1MF07/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P32241-1", "protein_name": "Vasoactive intestinal polypeptide receptor 1", "gene_name": "VIPR1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSLWWIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRHPSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV", "length": 457 }, "evidence": [ { "id": "F1MF07", "url": "https://omabrowser.org/oma/group/F1MF07/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P97751-1", "protein_name": "Vasoactive intestinal polypeptide receptor 1", "gene_name": "Vipr1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRPPSLPPARWLCVLAGALACALGPAGSRAASPHQECEYLQMIEKQRQQCLEEAQLENETTGCSKMWDNLTCWPTTPWGQVVVLDCPLIFQLFSPIHGYNISRNCTEEGWSQLEPGPYHIACGLNDRASSMDEQQQTEFYDAVKTGYTIGYSLSLASLLVAMAILSLFRKLHCTRNYIHMHLFMSFILRATAVFIKDMALFNNGETDHCSEASVSCKAAVVFFQYCVMANFFWLLVEGLYLHTLLAVSFFSERKYFWGYILIGWGVPSVFIMIWTIVRIHFEDFGCWDTIINSSLWWIIKGPILISILVNFILFICIIRILVQKLRPPDIGKNDSSPYSRLAKSTLLLIPLFGVHYVMFAFFPDNFKAQVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWSSKSQHPWGGSNGVSCSTQVSMLTRVSPSARRSSSFQAEVSLV", "length": 459 }, "evidence": [ { "id": "F1MF07", "url": "https://omabrowser.org/oma/group/F1MF07/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MF07", "url": "https://www.uniprot.org/uniprotkb/F1MF07" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MF07", "url": "https://www.uniprot.org/uniprotkb/F1MF07" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "F1MF07", "url": "https://www.uniprot.org/uniprotkb/F1MF07" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "F1MF07", "url": "https://www.uniprot.org/uniprotkb/F1MF07" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "F1MF07", "url": "https://www.uniprot.org/uniprotkb/F1MF07" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger", "id": "GO:0007187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007187", "evidence": [ { "database": "UniProtKB", "id": "F1MF07", "url": "https://www.uniprot.org/uniprotkb/F1MF07" } ], "pmid": "" }, { "name": "adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "id": "GO:0007188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007188", "evidence": [ { "database": "UniProtKB", "id": "F1MF07", "url": "https://www.uniprot.org/uniprotkb/F1MF07" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "vasoactive intestinal polypeptide receptor activity", "id": "GO:0004999", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004999", "evidence": [ { "database": "UniProtKB", "id": "F1MF07", "url": "https://www.uniprot.org/uniprotkb/F1MF07" } ], "pmid": "" }, { "name": "pituitary adenylate cyclase-activating polypeptide receptor activity", "id": "GO:0001634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001634", "evidence": [ { "database": "UniProtKB", "id": "F1MF07", "url": "https://www.uniprot.org/uniprotkb/F1MF07" } ], "pmid": "" }, { "name": "peptide hormone binding", "id": "GO:0017046", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017046", "evidence": [ { "database": "UniProtKB", "id": "F1MF07", "url": "https://www.uniprot.org/uniprotkb/F1MF07" } ], "pmid": "" }, { "name": "G protein-coupled peptide receptor activity", "id": "GO:0008528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008528", "evidence": [ { "database": "UniProtKB", "id": "F1MF07", "url": "https://www.uniprot.org/uniprotkb/F1MF07" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MF07-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 457, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MF07-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MF07" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MF07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF07" }, { "id": "PS50227", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50227" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 2 profile 1", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 127, "start_aa": "Gln", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MF07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF07" }, { "id": "PS50261", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50261" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 2 profile 2", "eco_id": "ECO_0000259", "start_pos": 143, "end_pos": 392, "start_aa": "Val", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 }, { "start_pos": 128, "end_pos": 130 }, { "start_pos": 291, "end_pos": 293 }, { "start_pos": 59, "end_pos": 61 }, { "start_pos": 70, "end_pos": 72 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MEP8-1", "uniprot_ac": "F1MEP8", "uniprot_id": "F1MEP8_BOVIN", "mass": { "chemical_mass": 96281.0, "monoisotopic_mass": 96281.0 }, "refseq": {}, "gene_names": [ { "name": "ATMIN", "type": "recommended", "evidence": [ { "id": "F1MEP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEP8" } ] } ], "protein_names": [ { "name": "ATM interactor", "type": "synonym", "evidence": [ { "id": "F1MEP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEP8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { 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"MRLRGTYTSYLFPGPPVKFYTPPASPGCAPPQTCPPPPAGGAATRAPPDANKAPPPAGSRCGGRRSRLAWSVCGARAMAASEAAAAADPAALASGAPAVPAAARGAAAASGPWVPPGRLRGSRPRPPPARQQPAGSAPPARELIQPSVSELSRAVRTNILCTVRGCGKILPNSPALNMHLVKSHRLQDGIVNPTVRKDLKTVPKFYCCPIEGCPRGPDRPFSQFSLVKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFQCTCGCPYASRTALQSHIYRTGHEIPAEHRDPPSKKRKMEGCLHSQKLSRKTVESLSKQPIPRPDAPQLETSEIKLVASFEDSCSSNAKQQTLAAAPRYPQKLLLPKPKVALVKLPVMQFSPVPVFVPTADSSAQPVVLGVDHQGSAPGAVHLLPLSIGTLILSLDSEACSLKESLPLSKVVNPVAVEPISTGIQVNLGKSPFSPLQELGNTCQKNSISSINVQTDLSYTTPQFMPTAQWASPDSSVSSCSQTDLTFGSQVSLPISVQTQTFLPSSKVTSSIAAQTDAFIDASFQPGGISRETQTSGMQSPADDRVQMDQAVMCGDIFESVHSSYGVSTDSIISSSLVAESVTHDLLPQNHAKTLTQDIEKSTPIINFSAPNSMLSSQNMTDNQTQTMDLLSDLENILSSNLPGQTLDNRSLLSDTNTGPDTQLPSGPTQNPAIDFDIEEFFSASNIQTQTEESELSTMTTEPVLESLDIETQTDFFLADPSAQAYSCRGNSSFLGLEMFDTQTQTDLNFFLDSSPRLPLGSILKHSSFSMSTDSSDTETQTDGISTAKNLPALESKVQLNSAETQTMNSGFETLGSLFFTSNETQTAMDDFLLADLAWNTMESQFSSVETQTCAELHPVSNF", "length": 899, "header": "tr|F1MEP8-1|F1MEP8_BOVIN Isoform 1 of ATM interactor OS=Bos taurus OX=9913 GN=ATMIN PE=4 SV=3 CANONICAL=F1MEP8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SDP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SDP3/entry", "sequence": { "sequence": "MLLSPHHNPESESEVSQSCLTLCDPVDCSPPGSSVHGILQDGIVNPTVRKDLKTVPKFYCCPIEGCPRGPDRPFSQFSLVKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFQCTCGCPYASRTALQSHIYRTGHEIPAEHRDPPSKKRKMEGCLHSQKLSRKTVESLSKQPIPRPDAPQLETSEIKLVASFEDSCSSNAKQQTLAAAPRYPQKLLLPKPKVALVKLPVMQFSPVPVFVPTADSSAQPVVLGVDHQGSAPGAVHLLPLSIGTLILSLDSEACSLKESLPLSKVVNPVAVEPISTGIQVNLGKSPFSPLQELGNTCQKNSISSINVQTDLSYTTPQFMPTAQWASPDSSVSSCSQTDLTFGSQVSLPISVQTQTFLPSSKVTSSIAAQTDAFIDASFQPGGISRETQTSGMQSPADDRVQMDQAVMCGDIFESVHSSYGVSTDSIISSSLVAESVTHDLLPQNHAKTLTQDIEKSTPIINFSAPNSMLSSQNMTDNQTQTMDLLSDLENILSSNLPGQTLDNRSLLSDTNTGPDTQLPSGPTQNPAIDFDIEEFFSASNIQTQTEESELSTMTTEPVLESLDIETQTDFFLADPSAQAYSCRGNSSFLGLEMFDTQTQTDLNFFLDSSPRLPLGSILKHSSFSMSTDSSDTETQTDGISTAKNLPALESKVQLNSAETQTMNSGFETLGSLFFTSNETQTAMDDFLLADLAWNTMESQFSSVETQTCAELHPVSNF", "length": 752, "header": "tr|A0AAA9SDP3-1|F1MEP8_BOVIN Computationally mapped isoform of ATM interactor OS=Bos taurus OX=9913 GN=ATMIN PE=4 SV=1 CANONICAL=F1MEP8-1" }, "locus": { "chromosome": "18", "start_pos": 7734823, "end_pos": 7729454, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133291.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133291.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084261.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084261.1" } ] } }, { "isoform_ac": "F1MEP8-1", "url": "https://www.uniprot.org/uniprotkb/F1MEP8/entry", "sequence": { "sequence": "MRLRGTYTSYLFPGPPVKFYTPPASPGCAPPQTCPPPPAGGAATRAPPDANKAPPPAGSRCGGRRSRLAWSVCGARAMAASEAAAAADPAALASGAPAVPAAARGAAAASGPWVPPGRLRGSRPRPPPARQQPAGSAPPARELIQPSVSELSRAVRTNILCTVRGCGKILPNSPALNMHLVKSHRLQDGIVNPTVRKDLKTVPKFYCCPIEGCPRGPDRPFSQFSLVKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFQCTCGCPYASRTALQSHIYRTGHEIPAEHRDPPSKKRKMEGCLHSQKLSRKTVESLSKQPIPRPDAPQLETSEIKLVASFEDSCSSNAKQQTLAAAPRYPQKLLLPKPKVALVKLPVMQFSPVPVFVPTADSSAQPVVLGVDHQGSAPGAVHLLPLSIGTLILSLDSEACSLKESLPLSKVVNPVAVEPISTGIQVNLGKSPFSPLQELGNTCQKNSISSINVQTDLSYTTPQFMPTAQWASPDSSVSSCSQTDLTFGSQVSLPISVQTQTFLPSSKVTSSIAAQTDAFIDASFQPGGISRETQTSGMQSPADDRVQMDQAVMCGDIFESVHSSYGVSTDSIISSSLVAESVTHDLLPQNHAKTLTQDIEKSTPIINFSAPNSMLSSQNMTDNQTQTMDLLSDLENILSSNLPGQTLDNRSLLSDTNTGPDTQLPSGPTQNPAIDFDIEEFFSASNIQTQTEESELSTMTTEPVLESLDIETQTDFFLADPSAQAYSCRGNSSFLGLEMFDTQTQTDLNFFLDSSPRLPLGSILKHSSFSMSTDSSDTETQTDGISTAKNLPALESKVQLNSAETQTMNSGFETLGSLFFTSNETQTAMDDFLLADLAWNTMESQFSSVETQTCAELHPVSNF", "length": 899, "header": "tr|F1MEP8-1|F1MEP8_BOVIN Isoform 1 of ATM interactor OS=Bos taurus 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"https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MEP8", "url": "https://www.uniprot.org/uniprotkb/F1MEP8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "F1MEP8", "url": "https://www.uniprot.org/uniprotkb/F1MEP8" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1MEP8", "url": "https://www.uniprot.org/uniprotkb/F1MEP8" } ], "pmid": "" }, { "name": "dynein complex binding", "id": "GO:0070840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070840", "evidence": [ { "database": "UniProtKB", "id": "F1MEP8", "url": "https://www.uniprot.org/uniprotkb/F1MEP8" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "F1MEP8", "url": "https://www.uniprot.org/uniprotkb/F1MEP8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MEP8", "url": "https://www.uniprot.org/uniprotkb/F1MEP8" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "F1MEP8", "url": "https://www.uniprot.org/uniprotkb/F1MEP8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 643, "end_pos": 645, "annotation": "n_glycosylation_sequon" }, { "start_pos": 655, "end_pos": 657, "annotation": 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"mass": { "chemical_mass": 43063.0, "monoisotopic_mass": 43063.0 }, "refseq": { "ac": "NP_001179714", "name": "LIM/homeobox protein Lhx4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179714" }, "gene_names": [ { "name": "LHX4", "type": "recommended", "evidence": [ { "id": "F1MFM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" } ] }, { "name": "LHX4", "type": "synonym", "evidence": [ { "id": "NP_001179714", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179714" } ] }, { "name": "LXH4", "type": "synonym", "evidence": [ { "id": "NP_001179714", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179714" } ] } ], "protein_names": [ { "name": "LIM homeobox 4", "type": "synonym", "evidence": [ { "id": "F1MFM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFM7/entry#names_and_taxonomy" } ] }, { "name": "LIM homeobox protein 4", "type": "synonym", "evidence": [ { "id": 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"NP_001179714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179714" }, { "database": "PubMed", "id": "19283511", "url": "https://glygen.org/publication/PubMed/19283511" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFM7", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LHX4", "url": "https://www.uniprot.org/uniprotkb/F1MFM7", "locus": { "chromosome": "16", "start_pos": 61474955, "end_pos": 61416843, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003992", "url": "https://www.ensembl.org/id/ENSBTAG00000003992" } ] } } ], "crossref": [ { "id": "F1MFM7", "url": "https://alphafold.ebi.ac.uk/entry/F1MFM7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003992", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003992", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09376", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09376", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09468", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09468", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540797", "url": "https://www.ncbi.nlm.nih.gov/gene/540797", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047956", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047956", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050453", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050453", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540797", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540797", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GLDYTMD", "url": "https://omabrowser.org/oma/group/GLDYTMD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MFM7", "url": "https://www.orthodb.org/?gene=F1MFM7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24208", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24208", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24208:SF116", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24208:SF116", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179714", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SEY0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGE2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQZ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5C8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFM7", "url": "https://www.uniprot.org/uniprotkb/F1MFM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFM7-1", "url": "https://www.uniprot.org/uniprotkb/F1MFM7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMQSAAVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGGSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVSGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPASWLDEMDHPPF", "length": 390, "header": "tr|F1MFM7-1|F1MFM7_BOVIN Isoform 1 of LIM homeobox 4 OS=Bos taurus OX=9913 GN=LHX4 PE=4 SV=2 CANONICAL=F1MFM7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEY0/entry", "sequence": { "sequence": "MTRFLPQQYLKEIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGGSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVSGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPASWLDEMDHPPF", "length": 376, "header": "tr|A0AAA9SEY0-1|F1MFM7_BOVIN Computationally mapped isoform of LIM homeobox 4 OS=Bos taurus OX=9913 GN=LHX4 PE=4 SV=1 CANONICAL=F1MFM7-1" }, "locus": { "chromosome": "16", "start_pos": 61473951, "end_pos": 61429063, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106763.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106763.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083949.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083949.1" } ] } }, { "isoform_ac": "A0AAA9SGE2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGE2/entry", "sequence": { "sequence": "MDEIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGGSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVSGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPASWLDEMDHPPF", "length": 367, "header": "tr|A0AAA9SGE2-1|F1MFM7_BOVIN Computationally mapped isoform of LIM homeobox 4 OS=Bos taurus OX=9913 GN=LHX4 PE=4 SV=1 CANONICAL=F1MFM7-1" }, "locus": { "chromosome": "16", "start_pos": 61473951, "end_pos": 61434530, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121926.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121926.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084435.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084435.1" } ] } }, { "isoform_ac": "A0AAA9SQZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQZ0/entry", "sequence": { "sequence": "MPRNSTVQQQYKSQPQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGGSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVSGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPASWLDEMDHPPF", "length": 380, "header": "tr|A0AAA9SQZ0-1|F1MFM7_BOVIN Computationally mapped isoform of LIM homeobox 4 OS=Bos taurus OX=9913 GN=LHX4 PE=4 SV=1 CANONICAL=F1MFM7-1" }, "locus": { "chromosome": "16", "start_pos": 61473951, "end_pos": 61418495, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135537.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135537.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085379.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085379.1" } ] } }, { "isoform_ac": "A0AAA9T5C8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C8/entry", "sequence": { "sequence": "MERAVPSVLQRKARLGLSAGFIHPLGLREIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGGSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVSGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPASWLDEMDHPPF", "length": 393, "header": "tr|A0AAA9T5C8-1|F1MFM7_BOVIN Computationally mapped isoform of LIM homeobox 4 OS=Bos taurus OX=9913 GN=LHX4 PE=4 SV=1 CANONICAL=F1MFM7-1" }, "locus": { "chromosome": "16", "start_pos": 61473951, "end_pos": 61433360, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114332.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114332.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093030.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093030.1" } ] } }, { "isoform_ac": "F1MFM7-1", "url": "https://www.uniprot.org/uniprotkb/F1MFM7/entry", "sequence": { "sequence": "MMQSAAVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGGSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVSGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPASWLDEMDHPPF", "length": 390, "header": "tr|F1MFM7-1|F1MFM7_BOVIN Isoform 1 of LIM homeobox 4 OS=Bos taurus OX=9913 GN=LHX4 PE=4 SV=2 CANONICAL=F1MFM7-1" }, "locus": { "chromosome": "16", "start_pos": 61473951, "end_pos": 61427758, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005216.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005216.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005216.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005216.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 360, "start_aa": "Thr", "end_pos": 360, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr360", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "A coding SNP of LHX4 gene is associated with body weight and body length in bovine.", "journal": "Molecular biology reports", "date": "2010-01", "authors": "Ren G, Chen H, Zhang L Z, Lan X Y, Wei T B, Li M J, Jing Y J, Lei C Z, Wang J Q", "evidence": [ { "database": "RefSeq", "id": "NP_001179714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179714" } ], "reference": [ { "type": "PubMed", "id": "19283511", "url": "https://glygen.org/publication/PubMed/19283511" } ] }, { "title": "Linkage disequilibrium and haplotype distribution of the bovine LHX4 gene in relation to growth.", "journal": "Gene", "date": "2014-04-01", "authors": "Ren Gang, Huang Yong-Zhen, Wei Tian-Bao, Liu Jun-Xia, Lan Xian-Yong, Lei Chu-Zhao, Zhang Chun-Lei, Zhang Zhi-Ying, Qi Xing-Lei, Chen Hong", "evidence": [ { "database": "RefSeq", "id": "NP_001179714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179714" } ], "reference": [ { "type": "PubMed", "id": "24463020", "url": "https://glygen.org/publication/PubMed/24463020" } ] } ], "pathway": [ { "id": "bta:540797", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540797", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7G2S2-1", "protein_name": "LIM/homeobox protein Lhx4", "gene_name": "Lhx4", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MMQSAAVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLVDRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGGSKQGKESSAEDCGVSDSELSFQEDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGVIAHAGQGVSQTLRAMAGGPTSDLSTGSSVGYPDFPTSPASWLDEMDHPPF", "length": 390 }, "evidence": [ { "id": "F1MFM7", "url": "https://omabrowser.org/oma/group/F1MFM7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "B0S5S7-1", "protein_name": "LIM/homeobox protein Lhx4", "gene_name": "lhx4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKMMQSAAVLPGESAVKGLPDILGVPLQQIPQCAGCSQHILDKFILKVLDRHWHSKCLKCADCHALLADKCFSRAGNVYCKEDFFKRFGTKCASCQQGIPPTQVVRKAQDFVYHLHCFACVMCSRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSETGAKRPRTTITAKQLETLKSAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRNRGSSKTEKESSADDAGLSDSELSFRDDQILSDLGHANGLYGSVGDVSNGNMLNGSFSLDGGGQPYHDLRAGSPYGLPQSPSSITSLPGHTPLLNNLGFSMDGLMGQAGQPSVGQALRAMAGGPTSDLSTGSSTGYPDFPTSPASWLDEMDHSQF", "length": 391 }, "evidence": [ { "id": "F1MFM7", "url": "https://omabrowser.org/oma/group/F1MFM7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1LZ08-1", "protein_name": "LIM homeobox 4", "gene_name": "Lhx4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMQSAAVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGGSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLSGLDYTVDSNLGVIAHPGQGVSQTLRAMAGGPTSDLSTGSSVGYPDFPTSPASWLDEMDHPPF", "length": 390 }, "evidence": [ { "id": "F1MFM7", "url": "https://omabrowser.org/oma/group/F1MFM7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S681-1", "protein_name": "LIM homeobox 4", "gene_name": "LHX4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMQSAAVPAEGAVKGLSEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLPCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIVAHAGQGGSQTLRAMAGGPTSDISTGSSVGYPDFPTSPASWLDEMDHPPF", "length": 390 }, "evidence": [ { "id": "F1MFM7", "url": "https://omabrowser.org/oma/group/F1MFM7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P53776-1", "protein_name": "LIM/homeobox protein Lhx4", "gene_name": "Lhx4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMQSAAVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGGSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDLSTGSSVGYPDFPTSPASWLDEMDHPPF", "length": 390 }, "evidence": [ { "id": "F1MFM7", "url": "https://omabrowser.org/oma/group/F1MFM7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q969G2-1", "protein_name": "LIM/homeobox protein Lhx4", "gene_name": "LHX4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF", "length": 390 }, "evidence": [ { "id": "F1MFM7", "url": "https://omabrowser.org/oma/group/F1MFM7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MFM7", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MFM7", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1MFM7", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" } ], "pmid": "" }, { "name": "methyl-CpG binding", "id": "GO:0008327", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008327", "evidence": [ { "database": "UniProtKB", "id": "F1MFM7", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "F1MFM7", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "F1MFM7", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "F1MFM7", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MFM7", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MFM7", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MFM7", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "F1MFM7", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MFM7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 390, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MFM7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MFM7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 155, "end_pos": 215, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MFM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFM7" }, { "id": "PS50023", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50023" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LIM zinc-binding", "eco_id": "ECO_0000259", "start_pos": 28, "end_pos": 87, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 360 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 287, "end_pos": 289 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MC31-1", "uniprot_ac": "F1MC31", "uniprot_id": "F1MC31_BOVIN", "mass": { "chemical_mass": 100243.0, "monoisotopic_mass": 100243.0 }, "refseq": { "ac": "XP_005227170", "name": "splicing factor 3B subunit 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227170" }, "gene_names": [ { "name": "SF3B2", "type": "recommended", "evidence": [ { "id": "F1MC31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC31" } ] }, { "name": "SF3B2", "type": "synonym", "evidence": [ { "id": "XP_005227170", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227170" } ] } ], "protein_names": [ { "name": "Splicing factor 3b subunit 2", "type": "synonym", "evidence": [ { "id": "F1MC31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC31/entry#names_and_taxonomy" } ] }, { "name": "splicing factor 3B subunit 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005227170", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227170" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MC31", "url": "https://www.uniprot.org/uniprotkb/F1MC31" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SF3B2", "url": "https://www.uniprot.org/uniprotkb/F1MC31", "locus": { "chromosome": "29", "start_pos": 44151409, "end_pos": 44137627, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002778", "url": "https://www.ensembl.org/id/ENSBTAG00000002778" } ] } } ], "crossref": [ { "id": "F1MC31", "url": "https://alphafold.ebi.ac.uk/entry/F1MC31", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002778", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002778", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "531931", "url": "https://www.ncbi.nlm.nih.gov/gene/531931", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006568", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006568", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007180", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007180", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052584", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052584", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12785", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12785", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12785:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12785:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72165", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9770562", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9943411", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9943411", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005227170", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227170", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SFK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC31", "url": "https://www.uniprot.org/uniprotkb/F1MC31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC31-1", "url": "https://www.uniprot.org/uniprotkb/F1MC31-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAEHPEPPKGELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGSREELVERLQTYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLSGIPMPPPPMGLPPLQPPPPPPPPPPGLGLGFPMAVGPRPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDTRSSLGHSASETEEDTMSVSKKEKNRKRRNRKKKKKPQRARAASSESSGDRDKESGRSRGSESPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKMENSAVPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAMTQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF", "length": 895, "header": "tr|F1MC31-1|F1MC31_BOVIN Isoform 1 of Splicing factor 3b subunit 2 OS=Bos taurus OX=9913 GN=SF3B2 PE=4 SV=2 CANONICAL=F1MC31-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFK9/entry", "sequence": { "sequence": "MAAEHPEPPKGELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGSREELVERLQTYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLSGIPMPPPPMGLPPLQPPPPPPPPPPGLGLGFPMAVGPRPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDTRSSLGHSASETEEDTMSVSKKEKNRKRRNRKKKKKPQRARAASSESSGDRDKESGRSRGSESPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKMENSAVPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAMTQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF", "length": 878, "header": "tr|A0AAA9SFK9-1|F1MC31_BOVIN Computationally mapped isoform of Splicing factor 3b subunit 2 OS=Bos taurus OX=9913 GN=SF3B2 PE=4 SV=1 CANONICAL=F1MC31-1" }, "locus": { "chromosome": "29", "start_pos": 44151245, "end_pos": 44137826, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111179.2", "url": "https://www.ensembl.org/id/ENSBTAT00000111179.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082393.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082393.1" } ] } }, { "isoform_ac": "F1MC31-1", "url": "https://www.uniprot.org/uniprotkb/F1MC31/entry", "sequence": { "sequence": "MAAEHPEPPKGELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGSREELVERLQTYTRQTGIVLNRPVLRGEDGDKAAPPPMSAQLSGIPMPPPPMGLPPLQPPPPPPPPPPGLGLGFPMAVGPRPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQQKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPTPTVLPMGAPVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDTRSSLGHSASETEEDTMSVSKKEKNRKRRNRKKKKKPQRARAASSESSGDRDKESGRSRGSESPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKMENSAVPKKKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDVTAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREALQEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETRLKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPESCSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSEEEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSETPQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAMTQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF", "length": 895, "header": "tr|F1MC31-1|F1MC31_BOVIN Isoform 1 of Splicing factor 3b subunit 2 OS=Bos taurus OX=9913 GN=SF3B2 PE=4 SV=2 CANONICAL=F1MC31-1" }, "locus": { "chromosome": "29", "start_pos": 44151245, "end_pos": 44137826, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003602.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003602.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003602.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003602.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 233, "start_aa": "Thr", "end_pos": 233, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr233", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" }, { "id": "R-BTA-72165", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "resource": "Reactome", "description": "mRNA Splicing - Minor Pathway" }, { "id": "R-BTA-9770562", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9770562", "resource": "Reactome", "description": "mRNA Polyadenylation" }, { "id": "R-BTA-9943411", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9943411", "resource": "Reactome", "description": "CHD1 and CHD2 subfamily" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MC31", "url": "https://www.uniprot.org/uniprotkb/F1MC31" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1MC31", "url": "https://www.uniprot.org/uniprotkb/F1MC31" } ], "pmid": "" }, { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "F1MC31", "url": "https://www.uniprot.org/uniprotkb/F1MC31" } ], "pmid": "" }, { "name": "U2 snRNP", "id": "GO:0005686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005686", "evidence": [ { "database": "UniProtKB", "id": "F1MC31", "url": "https://www.uniprot.org/uniprotkb/F1MC31" } ], "pmid": "" }, { "name": "precatalytic spliceosome", "id": "GO:0071011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071011", "evidence": [ { "database": "UniProtKB", "id": "F1MC31", "url": "https://www.uniprot.org/uniprotkb/F1MC31" } ], "pmid": "" }, { "name": "U12-type spliceosomal complex", "id": "GO:0005689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005689", "evidence": [ { "database": "UniProtKB", "id": "F1MC31", "url": "https://www.uniprot.org/uniprotkb/F1MC31" } ], "pmid": "" }, { "name": "U2-type spliceosomal complex", "id": "GO:0005684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005684", "evidence": [ { "database": "UniProtKB", "id": "F1MC31", "url": "https://www.uniprot.org/uniprotkb/F1MC31" } ], "pmid": "" }, { "name": "U2-type precatalytic spliceosome", "id": "GO:0071005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071005", "evidence": [ { "database": "UniProtKB", "id": "F1MC31", "url": "https://www.uniprot.org/uniprotkb/F1MC31" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "F1MC31", "url": "https://www.uniprot.org/uniprotkb/F1MC31" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MC31-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 895, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MC31-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MC31" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MC31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC31" }, { "id": "PS50800", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50800" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAP", "eco_id": "ECO_0000259", "start_pos": 24, "end_pos": 58, "start_aa": "Tyr", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 233 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": 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"table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MHZ3-1", "uniprot_ac": "F1MHZ3", "uniprot_id": "F1MHZ3_BOVIN", "mass": { "chemical_mass": 155663.0, "monoisotopic_mass": 155663.0 }, "refseq": { "ac": "XP_002693021", "name": "protein NPAT isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693021" }, "gene_names": [ { "name": "NPAT", "type": "recommended", "evidence": [ { "id": "F1MHZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHZ3" } ] }, { "name": "NPAT", "type": "synonym", "evidence": [ { "id": "XP_002693021", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693021" } ] } ], "protein_names": [ { "name": "Nuclear protein, coactivator of histone transcription", "type": "synonym", "evidence": [ { "id": "F1MHZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHZ3/entry#names_and_taxonomy" } ] }, { "name": "protein NPAT isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002693021", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693021" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MHZ3", "url": "https://www.uniprot.org/uniprotkb/F1MHZ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NPAT", "url": "https://www.uniprot.org/uniprotkb/F1MHZ3", "locus": { "chromosome": "15", "start_pos": 17789813, "end_pos": 17842981, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010286", "url": "https://www.ensembl.org/id/ENSBTAG00000010286" } ] } } ], "crossref": [ { "id": "ENSBTAG00000010286", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010286", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "526583", "url": "https://www.ncbi.nlm.nih.gov/gene/526583", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031442", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031442", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526583", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526583", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PMRSNFV", "url": "https://omabrowser.org/oma/group/PMRSNFV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MHZ3", "url": "https://www.orthodb.org/?gene=F1MHZ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15087", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15087", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15087:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15087:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15712", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15712", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002693021", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693021", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SFM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYU1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYU1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHZ3", "url": "https://www.uniprot.org/uniprotkb/F1MHZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHZ3-1", "url": "https://www.uniprot.org/uniprotkb/F1MHZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLPSDVARLVLGYLQQENLTSTCQAFILESSDLKEYAEHCTDEGFIPACLLSLFGKNLTTILNEYVAMKAKETSNDVPAIMSSLWKKLDHTLSQIRSMQSSPGFAASQRARTRNGIAEIKRQRRLASQAAPVSSEPLPYLLGQFTNSPLTATQVIRPTGQISAPLRSDFVVVNHSQSQDTMTTGEALNNNTGAQERKNHASLMSPGRRKSESQRKSGPHSTIRNLQDPNAFVVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDNSIAQVPKQTDSNPSEPETSIDELLGLQSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNISQGICSQHMETNPSVVLAGETNLAVKGTFETEESDDPSGQPSFCTSYQNEDTSNILKNGSNHDELRQEAQEHFSHIDSSIQKKAFKTVVSTEQKCNLDITFESVPSLSDFNERVNSDAECNQHCAELYTSQMSTETEMALEVEKNSLSPNVQNESQLQPDQSPIPISSVVSLGGETNSENLILSGKTSQLLPQNIPLAGKASKKGQFCESSDDTRRLKADFHNSKSPDSREIHQNKIEINNVLPVTSQHLRDCQDNSSLQILPASIENSGLTVSEQKGEIHLEDSVSSIKQPSNDSSSVELNHTIHETQSSKSEKAALDSQEPSSSVKEDGDSIFLSLGENNCEEVTLMPSESNPIEDRHSLPSESVCSSMRESHPESQNTNNKPANDKSTEIDASNIVSLKIIISDDPFVSSDTELNSAVSSISGENLPTIILSSPAKSPARNAELVKCLSSEETTGAISSAEGTGDSASMEQSLLALKPEDSKVNNMQNEDSIALSTNVTPCVSKDGGYIQLMPATSTTFGNSSNILIATCVTDPTALGTTVSQSNVVVLPGNSAPMTAQPPLSQLQTPPRSNSVFAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNTFSAPPRQVLHMPLAAPVCNRSISQFPIPQKSLKSQGLKNKPCTGKQVNNLVDSSSHSVGCHAQRTEVSDKIMATDLGKKLEETTVPFSVESTVPVSKPFESHRRVLCFDTTASPVANTQGTNQKLVSQSKERNDISFSNLDSPIVSSTLKPPANNAVRREREKPSMPKILSKSETPIGRHATIKETPSEKKVSPTETILESFHKATANKENELCSDVERQKNPETSKLSNGQQNGGVRNEKTVTSLQELTRKQGTSSNSKNVFSVGAPVKDLKQDQTRSASSLINPLTKHTTEMLQDTQWHSPVNRLTDSTDLSVPRTSSSGAGEKLKEEPTDGIKVPSSRRFGEDSTPKVMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSSTPLKDNTQQFRASSRSTTKKRKIEEVDEHERNSRTSNKGLANSSMPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE", "length": 1433, "header": "tr|F1MHZ3-1|F1MHZ3_BOVIN Isoform 1 of Nuclear protein, coactivator of histone transcription OS=Bos taurus OX=9913 GN=NPAT PE=4 SV=2 CANONICAL=F1MHZ3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SFM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM4/entry", "sequence": { "sequence": "MLLPSDVARLVLGYLQQENLTSTCQAFILESSDLKEYAEHCTDEGFIPACLLSLFGKNLTTILNEYVAMKAKARTRNGIAEIKRQRRLASQAAPVSSEPLPYLLGQFTNSPLTATQVIRPTGQISAPLRSDFVVVNHSQSQDTMTTGEALNNNTGAQERKNHASLMSPGRRKSESQRKSGPHSTIRNLQDPNAFVVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDNSIAQVPKQTDSNPSEPETSIDELLGLQSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNISQGICSQHMETNPSVVLAGETNLAVKGTFETEESDDPSGQPSFCTSYQNEDTSNILKNGSNHDELRQEAQEHFSHIDSSIQKKAFKTVVSTEQKCNLDITFESVPSLSDFNERVNSDAECNQHCAELYTSQMSTETEMALEVEKNSLSPNVQNESQLQPDQSPIPISSVVSLGGETNSENLILSGKTSQLLPQNIPLAGKASKKGQFCESSDDTRRLKADFHNSKSPDSREIHQNKIEINNVLPVTSQHLRDCQDNSSLQILPASIENSGLTVSEQKGEIHLEDSVSSIKQPSNDSSSVELNHTIHETQSSKSEKAALDSQEPSSSVKEDGDSIFLSLGENNCEEVTLMPSESNPIEDRHSLPSESVCSSMRESHPESQNTNNKPANDKSTEIDASNIVSLKIIISDDPFVSSDTELNSAVSSISGENLPTIILSSPAKSPARNAELVKCLSSEETTGAISSAEGTGDSASMEQSLLALKPEDSKVNNMQNEDSIALSTNVTPCVSKDGGYIQLMPATSTTFGNSSNILIATCVTDPTALGTTVSQSNVVVLPGNSAPMTAQPPLSQLQTPPRSNSVFAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNTFSAPPRQVLHMPLAAPVCNRSISQFPIPQKSLKSQGLKNKPCTGKQVNNLVDSSSHSVGCHAQRTEVSDKIMATDLGKKLEETTVPFSVESTVPVSKPFESHRRVLCFDTTASPVANTQGTNQKLVSQSKERNDISFSNLDSPIVSSTLKPPANNAVRREREKPSMPKILSKSETPIGRHATIKETPSEKKVSPTETILESFHKATANKENELCSDVERQKNPETSKLSNGQQNGGVRNEKTVTSLQELTRKQGTSSNSKNVFSVGAPVKDLKQDQTRSASSLINPLTKHTTEMLQDTQWHSPVNRLTDSTDLSVPRTSSSGAGEKLKEEPTDGIKVPSSRRFGEDSTPKVMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSSTPLKDNTQQFRASSRSTTKKRKIEEVDEHERNSRTSNKGLANSSMPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE", "length": 1395, "header": "tr|A0AAA9SFM4-1|F1MHZ3_BOVIN Computationally mapped isoform of Nuclear protein, coactivator of histone transcription OS=Bos taurus OX=9913 GN=NPAT PE=4 SV=1 CANONICAL=F1MHZ3-1" }, "locus": { "chromosome": "15", "start_pos": 17842715, "end_pos": 17790817, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135043.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135043.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082674.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082674.1" } ] } }, { "isoform_ac": "A0AAA9SYU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYU1/entry", "sequence": { "sequence": "MQNTVQMKVLSQPAYWSMQSSPGFAASQRARTRNGIAEIKRQRRLASQAAPVSSEPLPYLLGQFTNSPLTATQVIRPTGQISAPLRSDFVVVNHSQSQDTMTTGEALNNNTGAQERKNHASLMSPGRRKSESQRKSGPHSTIRNLQDPNAFVVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDNSIAQVPKQTDSNPSEPETSIDELLGLQSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNISQGICSQHMETNPSVVLAGETNLAVKGTFETEESDDPSGQPSFCTSYQNEDTSNILKNGSNHDELRQEAQEHFSHIDSSIQKKAFKTVVSTEQKCNLDITFESVPSLSDFNERVNSDAECNQHCAELYTSQMSTETEMALEVEKNSLSPNVQNESQLQPDQSPIPISSVVSLGGETNSENLILSGKTSQLLPQNIPLAGKASKKGQFCESSDDTRRLKADFHNSKSPDSREIHQNKIEINNVLPVTSQHLRDCQDNSSLQILPASIENSGLTVSEQKGEIHLEDSVSSIKQPSNDSSSVELNHTIHETQSSKSEKAALDSQEPSSSVKEDGDSIFLSLGENNCEEVTLMPSESNPIEDRHSLPSESVCSSMRESHPESQNTNNKPANDKSTEIDASNIVSLKIIISDDPFVSSDTELNSAVSSISGENLPTIILSSPAKSPARNAELVKCLSSEETTGAISSAEGTGDSASMEQSLLALKPEDSKVNNMQNEDSIALSTNVTPCVSKDGGYIQLMPATSTTFGNSSNILIATCVTDPTALGTTVSQSNVVVLPGNSAPMTAQPPLSQLQTPPRSNSVFAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNTFSAPPRQVLHMPLAAPVCNRSISQFPIPQKSLKSQGLKNKPCTGKQVNNLVDSSSHSVGCHAQRTEVSDKIMATDLGKKLEETTVPFSVESTVPVSKPFESHRRVLCFDTTASPVANTQGTNQKLVSQSKERNDISFSNLDSPIVSSTLKPPANNAVRREREKPSMPKILSKSETPIGRHATIKETPSEKKVSPTETILESFHKATANKENELCSDVERQKNPETSKLSNGQQNGGVRNEKTVTSLQELTRKQGTSSNSKNVFSVGAPVKDLKQDQTRSASSLINPLTKHTTEMLQDTQWHSPVNRLTDSTDLSVPRTSSSGAGEKLKEEPTDGIKVPSSRRFGEDSTPKVMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSSTPLKDNTQQFRASSRSTTKKRKIEEVDEHERNSRTSNKGLANSSMPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE", "length": 1352, "header": "tr|A0AAA9SYU1-1|F1MHZ3_BOVIN Computationally mapped isoform of Nuclear protein, coactivator of histone transcription OS=Bos taurus OX=9913 GN=NPAT PE=4 SV=1 CANONICAL=F1MHZ3-1" }, "locus": { "chromosome": "15", "start_pos": 17831174, "end_pos": 17790817, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130150.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130150.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090539.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090539.1" } ] } }, { "isoform_ac": "F1MHZ3-1", "url": "https://www.uniprot.org/uniprotkb/F1MHZ3/entry", "sequence": { "sequence": "MLLPSDVARLVLGYLQQENLTSTCQAFILESSDLKEYAEHCTDEGFIPACLLSLFGKNLTTILNEYVAMKAKETSNDVPAIMSSLWKKLDHTLSQIRSMQSSPGFAASQRARTRNGIAEIKRQRRLASQAAPVSSEPLPYLLGQFTNSPLTATQVIRPTGQISAPLRSDFVVVNHSQSQDTMTTGEALNNNTGAQERKNHASLMSPGRRKSESQRKSGPHSTIRNLQDPNAFVVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDNSIAQVPKQTDSNPSEPETSIDELLGLQSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNISQGICSQHMETNPSVVLAGETNLAVKGTFETEESDDPSGQPSFCTSYQNEDTSNILKNGSNHDELRQEAQEHFSHIDSSIQKKAFKTVVSTEQKCNLDITFESVPSLSDFNERVNSDAECNQHCAELYTSQMSTETEMALEVEKNSLSPNVQNESQLQPDQSPIPISSVVSLGGETNSENLILSGKTSQLLPQNIPLAGKASKKGQFCESSDDTRRLKADFHNSKSPDSREIHQNKIEINNVLPVTSQHLRDCQDNSSLQILPASIENSGLTVSEQKGEIHLEDSVSSIKQPSNDSSSVELNHTIHETQSSKSEKAALDSQEPSSSVKEDGDSIFLSLGENNCEEVTLMPSESNPIEDRHSLPSESVCSSMRESHPESQNTNNKPANDKSTEIDASNIVSLKIIISDDPFVSSDTELNSAVSSISGENLPTIILSSPAKSPARNAELVKCLSSEETTGAISSAEGTGDSASMEQSLLALKPEDSKVNNMQNEDSIALSTNVTPCVSKDGGYIQLMPATSTTFGNSSNILIATCVTDPTALGTTVSQSNVVVLPGNSAPMTAQPPLSQLQTPPRSNSVFAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNTFSAPPRQVLHMPLAAPVCNRSISQFPIPQKSLKSQGLKNKPCTGKQVNNLVDSSSHSVGCHAQRTEVSDKIMATDLGKKLEETTVPFSVESTVPVSKPFESHRRVLCFDTTASPVANTQGTNQKLVSQSKERNDISFSNLDSPIVSSTLKPPANNAVRREREKPSMPKILSKSETPIGRHATIKETPSEKKVSPTETILESFHKATANKENELCSDVERQKNPETSKLSNGQQNGGVRNEKTVTSLQELTRKQGTSSNSKNVFSVGAPVKDLKQDQTRSASSLINPLTKHTTEMLQDTQWHSPVNRLTDSTDLSVPRTSSSGAGEKLKEEPTDGIKVPSSRRFGEDSTPKVMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSSTPLKDNTQQFRASSRSTTKKRKIEEVDEHERNSRTSNKGLANSSMPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE", "length": 1433, "header": "tr|F1MHZ3-1|F1MHZ3_BOVIN Isoform 1 of Nuclear protein, coactivator of histone transcription OS=Bos taurus OX=9913 GN=NPAT PE=4 SV=2 CANONICAL=F1MHZ3-1" }, "locus": { "chromosome": "15", "start_pos": 17842715, "end_pos": 17790817, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013589.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013589.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013589.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013589.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1291, "start_aa": "Thr", "end_pos": 1291, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1291", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:526583", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526583", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IH22-1", "protein_name": "Protein NPAT isoform X1", "gene_name": "npat", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLLPSDVARLVLGYLQQEGLNATSRAFIYESPNLKEYAEHSSEDGIIPACVFSLFGKNLITILNEYVAVKTKETCQENQIPAVMTSLWKKLDFTLSQIKSLQNSPAVQLNQRMRTRNSIQNMRRQQRPLLVVESPISGHQPVTPSGQCVVASTVSTPQSMLGHSTPVSYTSLPTRPSTLCLSQPGESTLHILVPDNRLNPGPLSPARRKCDSPRRRGGGQLGAIGTSKATVVSSSLIVENQNEETVTENLSQIVIENAREKILNDRSLQEKLAENINKILGSDNSPQTSKATCSTVEQEQSIDEILGLQGEIHMTDDAIQDILAQTESDPAFQALFDLFDCGKSKTAEGGEQADGSFSTSTSAQESDEAGHVDSASENATGQEDSTSGGESSAQNIRNQNTSESNGKKNFPGLHKSSSTAPQAHHLTKQTGRGSTNSKRGLIRARVSPGNKQSRVATSTSLLLNDKADSRSPDKTVTSSSFTEDGIGMEIDEPENENSDSVNIQNQQVVLHESSLITKTLNNVSSQVSVSNKSPQTTSTTETSDNTSVNEPGRVTGQNVEMETPSSIQSEPASTLYQPQPDRDTSIKITSPPSSNKTPVTPSYTSNTMKNNLPLANASPSTSTTSASGAQVKEPDPNKIVSLKIIISDEEHEVPADAALNQAVSSITSDHIPTIFLSSPAKSPAKTLPMTSLVITQDETAQAVSCLQGAEGVGSFATPTMSLQSNAPLTRLAGQETGFIQLLQANPTFGPSSGYYVVTDPAGTEQRSNVVLLPSNVPQGTVSSLPHMVATPPRQRTVVSMGPNVSQTYSPGSTIIISSPVQPMLQNVVLPVSVMGQNTGKLTVLPNQMLTLPRSTTVRQPTKVISQHKLAPKENTDTAKTGTPGSVQVSKVLSQTSEQEKGVNGSSPSHRRILCFDVTPENNATGPNSSQTSMLTSSAVTSSSTQKEITPTKAKQPSASDTSKRRIETTRLPEVNTNTGAKDSTKVTIFHQQKEALKSSVTDKELNIIESTKPSHKESVVISESSQKSQSKDAGPLTSSVPGPKQKPSDNSKESSGEKTLSNPPEMSSEKTSLQDSPGITANKENELESSQTLARPTDNLVPSPAKFATPLLNSSSKTLCKTSPLTKQAVEMLQDIQGQTPVATPPKKQAIGCPDLPLPRTPGPGRALEDLTDGLRTPSRQRLRREGECTPRHLPLPATPDIPSCSPASETGSENSINMAAHTLMILSRAARTGGPLKDSLRQEEAGAGKSAISKGKKRKIEASPTAKKELQLSRSSSGKKKSKKQKKLLDSFPDDLDVDKFLSSLHYDE", "length": 1310 }, "evidence": [ { "id": "F1MHZ3", "url": "https://omabrowser.org/oma/group/F1MHZ3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0XE31-1", "protein_name": "Nuclear protein, coactivator of histone transcription", "gene_name": "NPAT", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLLPSDVARLVLGYLQQEKLLATCREFILESSDLKEYAEHCTEDGFIPACLLSLCGKNLTTILNEYVAMKTKETTNEVPAMMSSLWKKLDYTLSQIRSMQGSTGFSANQRTRTRSGIVEMKRQRMLQQSAPPNSGLLSVAPQPGPQYHSSTISPQVIHKPAINQSISQARLNTLFVHQPQAQENRIGTGDFIHIQVPASQERKLHSNLLSPGRRKSESQKRRSVATSGPPAGSRSSQDPDEVIIEKESEPLEEFIDGNFPQLIIENAREKILSNKSLQEKLAENINKILGSDGSVTQAPKQTESGPTEQETSIDEILGLQGEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKNKVNKNLPAGISGQSGVENTILVDADNLETLESSLGTEETSKCDSSREVLSCKGFQLEETSCALKNPINDDNMAKKNATSEQLHGNCRLRKEADVLKTITHEHIGELEIAFDSVPVLTESNKRQISDGEHHEHCQDSYGKKDSSTPVPGSEKCMEIEKDTLSHSTQSSPNLEYVHSGSPQIPLVSLEEGCRANENRTRPAGKCHFSPHTSVPEKTLTKSPSDGSPAHSALLRKNNTSISSPSADAGKEQAVANDTAPLLNISQENLSHHTNQQDQSVQSDCATKSAVNMSDLDKTELQLEAAGTCKKTQPDDQRALDNPKKDFNLPSGLSNSEGAQVEMQETSSSAKADTDNIYFSSGDDACTGISVVPTENNLTASEMCHSPLPETTSSTDELSTKAKSASGVSSSSQPMDVDPSNIMSLKIIISDDPFISSDTELNNAVSSITGENLPTIILSSPAKSPNKTAGLSKCLTSEDTEKNVESALAEQNLLVLRPKDPVVTAVNTQNEDCTVFSVASTSNLSKEGGFIQLMPATSTAFGSTNNLYIATCVTDPAALGTAVTPSNVVVLPGSSMPLAAQAPAVQQLRTPPRSSSTFAGNQAVSPGFPQGSAIIITSPVQPVLQGMVGMIPLSVVGQNGNSFSAPARQVLHMPVANPVCNRNVPKLPIPPKSQKIPGARNKTNAGKPVPSVSETSNHINARTQRAGNSDKLITAELGRKAEENLPAAPAESTSSNSRQGESHRRVLCFDNILPAAGGNTQAQTAKSLPQKERNENSSFPVDSAPSSAKTQAAKREKDKTLPRILCKPEVAGNRSTAVKEPQPERKVVTAGLPSDPFHKATANKENELRRDSDEKQKNQDTAKLSNGQQSVSLWNEKTVASVQELNKKQASLSNGNSKSSPSVSLSSKEPKREAAKVSNQGLCLSSPFTKQCVEMLQDIQWHSPSSKTVENGELPVPRTPSGVGDRHTDDTTDSVRTPTCRRFNEDSATPRIMVPPATPDLPACSPASETGSENSVSMAAHTLMILSRAAIARTSAATPLKDNTQQFRSLRSTVKKRKLEDLNEGERNSRSTNRKDLQSSPTPSKKKKIKKKKLPNSFPAGMDVDKFLLSLHYDE", "length": 1465 }, "evidence": [ { "id": "F1MHZ3", "url": "https://omabrowser.org/oma/group/F1MHZ3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A6Y1-1", "protein_name": "Nuclear protein, co-activator of histone transcription", "gene_name": "Npat", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLPSDVARLVLGYLQQENLTSTCQTFILESSNLKEYAEHCTDEGFIPACLLSLFGKNLTTILNEYVAMKAKETSNDVPTIMSSLWKKLDHTLSQIRSMQSSPGFAAHQRARTRNGIAEIKRQRWLASQAAPVSSELLVLPYASGQFTTSPLAATQTIKPTGQISTPVRSNIVVVNHSQTQNTVTNTAGESLNIIPGPQERKTQTSLMSPGRRKSESQKKSLPSSGAHSSRNLQDPNAFAVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDSNIAQVPKQTESSLTEPETSIDELLGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNISQSVSSQSVETNPNIVIPEETNLTIKSSFETEESDGQSGQPPFCTSYQNEDVVLNDLKSGNNHDVLPQESQGNFSQISANIQKTAVPAEQKCALDITFESVSNLSDFNQRGSATECDEHCSELYTSQMPTDAGAAVGEESSLSPDSLNQSQYQPDQPRVPVTSFVSLGGETNDKNLILSGKNSQLLSQSTPLTGKPSKSQFCENSNNIIKVKTNSHASESPDSSDTHSSKDETNSKSPVAAQTQPDCQDNSPLQSRTSPVIIEGLGVNVTEKIEISIEETSPSDKQLPNDSASVDLNPMGSESEPLQSENTQEPPSVKDGDTIFLSLSGHNGCEEVALVPGEGNPVKNNHSLSSESGGSVGVSAETQNTDGKASDPAEVDASSIVSLKIIISDDPFVSSDAELNSAVSSISGENLPTIILSSKSPAKNAEFVTCLSSEETASAVVSVEVGDSGSMEQNLLVLKPEEPTVNSTQNEDGIAFSANVAPCVPKDGGFIQLMPATSTAFGNSSNILIATCMTDPTALGPTVSQSNVVVLPGSSAPLTAQPPPQQLQTPPKSNSAFAVSQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNTFSTPPQQVLHMPLAAPVCNRSITQFPIPQKSQKAQGLRNKPITGKQVNNLTSLSSLSEACHTQRTEASDKNTATELGKKMEDTTIPLSAERVAPPSRPFESHRRVLCFDSTVSSVANTQGPLYKVTSQNKEKKETSFPRLDSPILSSTLKSPTNNAIKREREKTVPKILSKSETASSRHTTVKEVQSEKKVSPIETTLESFHKATANKENELCSDGERPKNPDTSKLPGGQQNGSLKNEKAMASLQELTRKQATPSNNKNATTVSGTVKDQKQEQSKPAGSLTGLETLQDVPLHNPANRTADSDLPGPRTTGAGAGEKHKEEPTDSMKAPASRRCGEEGSVPRAMIPAVTADLPACSPASETGSENSVSMAAHTLMILSRAAIARTTATPLKDNTQQFRTSSRSTTKKRKIEELDECERNSRTSSKNLANSSVPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE", "length": 1415 }, "evidence": [ { "id": "F1MHZ3", "url": "https://omabrowser.org/oma/group/F1MHZ3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14207-1", "protein_name": "Protein NPAT", "gene_name": "NPAT", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLPSDVARLVLGYLQQENLISTCQTFILESSDLKEYAEHCTDEGFIPACLLSLFGKNLTTILNEYVAMKTKETSNNVPAIMSSLWKKLDHTLSQIRSMQSSPRFAGSQRARTRTGIAEIKRQRKLASQTAPASAELLTLPYLSGQFTTPPSTGTQVTRPSGQISDPSRSYFVVVNHSQSQDTVTTGEALNVIPGAQEKKAHASLMSPGRRKSESQRKSTTLSGPHSTIRNFQDPNAFAVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDNNIAQVPKQTDNNPTEPETSIDEFLGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNISQSISSQPMESNPSIVLADETNLAVKGSFETEESDGQSGQPAFCTSYQNDDPLNALKNSNNHDVLRQEDQENFSQISTSIQKKAFKTAVPTEQKCDIDITFESVPNLNDFNQRGNSNAECNPHCAELYTNQMSTETEMAIGIEKNSLSSNVPSESQLQPDQPDIPITSFVSLGCEANNENLILSGKSSQLLSQDTSLTGKPSKKSQFCENSNDTVKLKINFHGSKSSDSSEVHKSKIEINVLEPVMSQLSNCQDNSCLQSEILPVSVESSHLNVSGQVEIHLGDSLSSTKQPSNDSASVELNHTENEAQASKSENSQEPSSSVKEENTIFLSLGGNANCEKVALTPPEGTPVENSHSLPPESVCSSVGDSHPESQNTDDKPSSNNSAEIDASNIVSLKVIISDDPFVSSDTELTSAVSSINGENLPTIILSSPTKSPTKNAELVKCLSSEETVGAVVYAEVGDSASMEQSLLTFKSEDSAVNNTQNEDGIAFSANVTPCVSKDGGYIQLMPATSTAFGNSNNILIATCVTDPTALGTSVSQSNVVVLPGNSAPMTAQPLPPQLQTPPRSNSVFAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNNFSTPPRQVLHMPLTAPVCNRSIPQFPVPPKSQKAQGLRNKPCIGKQVNNLVDSSGHSVGCHAQKTEVSDKSIATDLGKKSEETTVPFPEESIVPAAKPCHRRVLCFDSTTAPVANTQGPNHKMVSQNKERNAVSFPNLDSPNVSSTLKPPSNNAIKREKEKPPLPKILSKSESAISRHTTIRETQSEKKVSPTEIVLESFHKATANKENELCSDVERQKNPENSKLSIGQQNGGLRSEKSIASLQEMTKKQGTSSNNKNVLSVGTAVKDLKQEQTKSASSLITTEMLQDIQRHSSVSRLADSSDLPVPRTPGSGAGEKHKEEPIDIIKAPSSRRFSEDSSTSKVMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSATPLKDNTQQFRASSRSTTKKRKIEELDERERNSRPSSKNLTNSSIPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE", "length": 1427 }, "evidence": [ { "id": "F1MHZ3", "url": "https://omabrowser.org/oma/group/F1MHZ3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BMA5-1", "protein_name": "Protein NPAT", "gene_name": "Npat", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLPSDVARLVLGYLQQENLTSTCQTFILESSNLKEYAEHCTDEGFIPACLLSLFGKNLTTILNEYVAMKAKETSNDVPTIMSSLWKKLDHTLSQIRSMHSSPGFAAHQRARTRNGIAEIKRQRWLASQAAPVSSELLVLPYASGQFTTSPLVATQAVKPTGPISTPVRSNIVVVNQSQPQSTVTNTAGESLNIIPGPQERKTQTSLMSPGRRKSESQKKSLTSSGPHSSRNFQDPNAFAVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDSSVAQVPKQTDSNPTEPETSIDELLGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNMPQISSQPMETNSNIVLPEETNLTIKSSFETEESDGQSGQPPFCTSYQNEDVLLNDLKSGNSHDVLPQESQENFSQISSNIQKKTFKTAIPAEQKCALDITLESVSNLSDFNQRGSSAECNEHCSELFASQIPTEAEVAVGEKNSLSADILSQSQYQPDQPSVPVTSFVSLGGETNDKNLVLSGKNSQLLSQSTPLTTKPSKSQLCENSNNIIKVKTNPQASESADSSETANRKTETNTVSPAAAQPQADCQDNSPLQSKPPPGIGESLGVNVTEKIEIHLEEPAPSDKQLSNDAASVDLNPTESKTEPLQSASAQEPEPPSVKDGDTIFLSLSEHNSCEEVALVLGEGNPVKNNNSLSSESGGSVGVSPETQNTDGKTSNSTEVDASSIVSLKIIISDDPFVSSDAELNSAVSSISGENLPTIILSSKSPAKNAEFVTCLSSEETASAVVSVEVGDSGSMEQNLLVLKPEEPMVNNTQNEDGIAFSANVAPCVPKDGGYIQLMPTTSTAFGNSSNILIATCMTDSTALGPTVSQSNVVVLPGSSAPMTAQPPQQQLQTPPKSNSAFAVSQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNTFSTPPQQVLHMPLAAPVCNRSIAQLPIPQKSQKAQGLRNKLITGKQVNNLTNLSSLSEACHTQRTEASDKNIATELGKKMEDTTISLSGERVAPPSKPFESHRRVLCFDSTVSSVANTQGSLYKMTSENKEKKEASFSHLDSPILSSTLKPPPNNAIKREREKTVPKILSKSETASSRHTTVKEVQSEKKVSPTEVALESLHKATANKENELCGDGERPKNADTSKLPGGQQNGSLRNEKAIASLQELTKKQATPSNNKNATSVGGTVKDQKQEQSKPASSLIGAEILQDVPIHSPANRSADTDLPVPRTPGSGAGEKHKEEPSDSMKAPASRRCGEEGSMPRVMIPPVTADLPACSPASETGSENSVSMAAHTLMILSRAAIARTTATPLKDNTQQFRTSSRSTTKKRKIEELDECERNSRTSGKNLANSSVPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE", 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} ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MHZ3", "url": "https://www.uniprot.org/uniprotkb/F1MHZ3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MHZ3", "url": "https://www.uniprot.org/uniprotkb/F1MHZ3" } ], "pmid": "" }, { "name": "Cajal body", "id": "GO:0015030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015030", "evidence": [ { "database": "UniProtKB", "id": "F1MHZ3", "url": "https://www.uniprot.org/uniprotkb/F1MHZ3" } ], "pmid": "" }, { "name": "Gemini of Cajal bodies", "id": "GO:0097504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097504", "evidence": [ { "database": "UniProtKB", "id": "F1MHZ3", "url": "https://www.uniprot.org/uniprotkb/F1MHZ3" } ], "pmid": "" } ] }, { 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"database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MEP0", "url": "https://www.orthodb.org/?gene=F1MEP0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR28554", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28554", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28554:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28554:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04280", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04280", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9937383", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SG39", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG39-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEP0", "url": "https://www.uniprot.org/uniprotkb/F1MEP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEP0-1", "url": "https://www.uniprot.org/uniprotkb/F1MEP0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPLPRSLSCLSRAVGWWSRQPILMTQSTAVVPVRTKKRFTPPIYQPKYKTEKEFTEYARKAGLVIPQESLERPIHLACTASIFDAYVPPEGDARVSSLSKEGLAQRTERLKKNVASQLSIRRIKESDPNFKVKDFPEKAQDIFIEAHLCLNNSDHDRLHTLVTENCFPDMVWDIKYKTVRWSFVESLEPPQVVQVRCSSLVTKSNAYGQVTVRMHTRQTLAIYDRFGRLMYGQEDVPRDVLEYVVFEKHLANPYGSWRMHGKIVPPWAPPKQPILKTVMIPGPQLKPGEEYEELQREAHKPQLA", "length": 306, "header": "tr|F1MEP0-1|F1MEP0_BOVIN Isoform 1 of Large ribosomal subunit protein mL45 OS=Bos taurus OX=9913 GN=MRPL45 PE=3 SV=1 CANONICAL=F1MEP0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG39-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG39/entry", "sequence": { "sequence": "MAAPLPRSLSCLSRAVGWWSRQPILMTQSTAVVPVRTKKRFTPPIYQPKYKTEKEFTEYARKAGLVIPQESLERPIHLACTASIFDAYVPPEGDARVSSLSKEGLAQRTERLKKNVASQLSIRRIKESDPNFKVKDFPEKAQDIFIEAHLCLNNSDHDRLHTLVTENCFPTLAIYDRFGRLMYGQEDVPRDVLEYVVFEKHLANPYGSWRMHGKIVPPWAPPKQPILKTVMIPGPQLKPGEEYEELQREAHKPQLA", "length": 256, "header": "tr|A0AAA9SG39-1|F1MEP0_BOVIN Computationally mapped isoform of Large ribosomal subunit protein mL45 OS=Bos taurus OX=9913 GN=MRPL45 PE=3 SV=1 CANONICAL=F1MEP0-1" }, "locus": { "chromosome": "19", "start_pos": 38985182, "end_pos": 38966325, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115514.2", "url": "https://www.ensembl.org/id/ENSBTAT00000115514.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082627.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082627.1" } ] } }, { "isoform_ac": "F1MEP0-1", "url": "https://www.uniprot.org/uniprotkb/F1MEP0/entry", "sequence": { "sequence": "MAAPLPRSLSCLSRAVGWWSRQPILMTQSTAVVPVRTKKRFTPPIYQPKYKTEKEFTEYARKAGLVIPQESLERPIHLACTASIFDAYVPPEGDARVSSLSKEGLAQRTERLKKNVASQLSIRRIKESDPNFKVKDFPEKAQDIFIEAHLCLNNSDHDRLHTLVTENCFPDMVWDIKYKTVRWSFVESLEPPQVVQVRCSSLVTKSNAYGQVTVRMHTRQTLAIYDRFGRLMYGQEDVPRDVLEYVVFEKHLANPYGSWRMHGKIVPPWAPPKQPILKTVMIPGPQLKPGEEYEELQREAHKPQLA", "length": 306, "header": "tr|F1MEP0-1|F1MEP0_BOVIN Isoform 1 of Large ribosomal subunit protein mL45 OS=Bos taurus OX=9913 GN=MRPL45 PE=3 SV=1 CANONICAL=F1MEP0-1" }, "locus": { "chromosome": "19", "start_pos": 38985182, "end_pos": 38966325, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034867.4", "url": "https://www.ensembl.org/id/ENSBTAT00000034867.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034751.1", "url": "https://www.ensembl.org/id/ENSBTAP00000034751.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5389840", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-BTA-5419276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5419276", "resource": "Reactome", "description": "Mitochondrial translation termination" }, { "id": "R-BTA-9937383", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9937383", "resource": "Reactome", "description": "Mitochondrial ribosome-associated quality control" } ], "orthologs": [ { "uniprot_canonical_ac": "E9QEK4-1", "protein_name": "Large ribosomal subunit protein mL45", "gene_name": "mrpl45", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAASICRTLKCLQPTSCQNIKYGSSLLDVRLWQAVLRVPVRTKRRLFIPPSANIKSKTQDEQEKKARAAGVVVRQEYMERPINISCTAGIYDPYVPPEGDARLSTLTKEGLKQRTEQLRQTAASQLAIRKIKDYDSTFTSKEFPGIGQQIFIDAHAALTEFNKEKLHSLVTERCYPEMVRGNRYKTLRWRFIESLEPPRLVQARCPDMISKGNLYGQVTVRMHSRQTLAIYDRFGRLMLGDEEEPRDVLEYLVMERHLVNPYGRWRLHGKIVPAWAPPKDPIIKTVMIPGPKLKSGEQFEDLNYQIPKPNAVQWHK", "length": 316 }, "evidence": [ { "id": "F1MEP0", "url": "https://omabrowser.org/oma/group/F1MEP0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "I3LGM5-1", "protein_name": "Large ribosomal subunit protein mL45", "gene_name": "MRPL45", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAPVTRGLSCLPRVLGWWSRQPVLVTQSTAVVPVRTKKRFTPPTYQPKYKSEKEFVEHARKAGLVIPHERLERPIHLACTAGIFDAYVPPEGDARISSLSKEGLAQRAERLKKNVASQLSIRKIRESDPNFKIKDFPEKAKDIFIEAHLCLNNSDHDRLHTLVTENCFPDMVWDIRYKTVRWSFVESLEPPQVVQVRCSSLMNQGNIYGQVTVRMHTRQTLAIYDRFGRLMYGQEDVPRDVLEYVVFEKHLVDPYGSWRMHGKIIPPWAPPKQPILKTVMIPGPQLKPWEEFEEPQGEVHKPQPA", "length": 306 }, "evidence": [ { "id": "F1MEP0", "url": "https://omabrowser.org/oma/group/F1MEP0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9BRJ2-1", "protein_name": "Large ribosomal subunit protein mL45", "gene_name": "MRPL45", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPIPQGFSCLSRFLGWWFRQPVLVTQSAAIVPVRTKKRFTPPIYQPKFKTEKEFMQHARKAGLVIPPEKSDRSIHLACTAGIFDAYVPPEGDARISSLSKEGLIERTERMKKTMASQVSIRRIKDYDANFKIKDFPEKAKDIFIEAHLCLNNSDHDRLHTLVTEHCFPDMTWDIKYKTVRWSFVESLEPSHVVQVRCSSMMNQGNVYGQITVRMHTRQTLAIYDRFGRLMYGQEDVPKDVLEYVVFEKQLTNPYGSWRMHTKIVPPWAPPKQPILKTVMIPGPQLKPEEEYEEAQGEAQKPQLA", "length": 306 }, "evidence": [ { "id": "F1MEP0", "url": "https://omabrowser.org/oma/group/F1MEP0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1MEP0", "url": "https://www.uniprot.org/uniprotkb/F1MEP0" } ], "pmid": "" }, { "name": "ribosome", "id": "GO:0005840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005840", "evidence": [ { "database": "UniProtKB", "id": "F1MEP0", "url": "https://www.uniprot.org/uniprotkb/F1MEP0" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "F1MEP0", "url": "https://www.uniprot.org/uniprotkb/F1MEP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MEP0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 306, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MEP0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MEP0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MEP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEP0" }, { "id": "SM00978", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00978" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tim44-like", "eco_id": "ECO_0000259", "start_pos": 118, "end_pos": 266, "start_aa": "Ser", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 153, "end_pos": 155 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BQ34-1", "uniprot_ac": "E1BQ34", "uniprot_id": "E1BQ34_BOVIN", "mass": { "chemical_mass": 130803.0, "monoisotopic_mass": 130803.0 }, "refseq": { "ac": "NP_001103468", "name": "homeodomain-interacting protein kinase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103468" }, "gene_names": [ { "name": "HIPK1", "type": "recommended", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "name": "HIPK1", "type": "synonym", "evidence": [ { "id": "NP_001103468", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103468" } ] } ], "protein_names": [ { "name": "non-specific serine/threonine protein kinase", "type": "recommended", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34/entry#names_and_taxonomy" } ] }, { "name": "homeodomain-interacting protein kinase 1", "type": "synonym", "evidence": [ { "id": "NP_001103468", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103468" } ] } ], "function": [ { "annotation": "TNFalpha-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha-induced ASK1-JNK/p38 activation", "evidence": [ { "database": "RefSeq", "id": "NP_001103468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103468" }, { "database": "PubMed", "id": "15701637", "url": "https://glygen.org/publication/PubMed/15701637" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BQ34", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HIPK1", "url": "https://www.uniprot.org/uniprotkb/E1BQ34", "locus": { "chromosome": "3", "start_pos": 29399811, "end_pos": 29449947, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011322", "url": "https://www.ensembl.org/id/ENSBTAG00000011322" } ] } } ], "crossref": [ { "id": "E1BQ34", "url": "https://alphafold.ebi.ac.uk/entry/E1BQ34", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011322", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011322", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14228", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14228", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512233", "url": "https://www.ncbi.nlm.nih.gov/gene/512233", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512233", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512233", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QVNAHSH", "url": "https://omabrowser.org/oma/group/QVNAHSH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BQ34", "url": "https://www.orthodb.org/?gene=E1BQ34", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24058", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24058", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24058:SF43", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24058:SF43", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804756", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001103468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103468", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SG61", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SG61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGU1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BQ34", "url": "https://www.uniprot.org/uniprotkb/E1BQ34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BQ34-1", "url": "https://www.uniprot.org/uniprotkb/E1BQ34-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSASAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAVIPEAMGSGQQLTDWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPAVSVITIRSDTDEEEDNKYKPNSSGLKARSNVISYVTVNDSPDSDSSLSSPYSTETLSALRGNSGSLPEGPGRVVGDGPGTRTIIVPPLKTQLGDCTVATQASGLLSSKTKPVASVSGQSSGCCITPTGYRAQRGGTSAAQPLNLSQNQQSSSAPTSQERSSNPAPRRQQAFVAPLSQAPYAFQHGSPLHSTGHPHLAPAPAHLPSQPHLYTYAAPTSAAALGPTTSIAHLFSPQGSSRHAAAYATHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL", "length": 1210, "header": "tr|E1BQ34-1|E1BQ34_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=HIPK1 PE=3 SV=1 CANONICAL=E1BQ34-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SG61-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG61/entry", "sequence": { "sequence": "MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSASAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAVIPEAMGSGQQLTDWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPAVSVITIRSDTDEEEDNKYKPNSSGLKARSNVISYVTVNDSPDSDSSLSSPYSTETLSALRGNSGSLPEGPGRVVGDGPGTRTIIVPPLKTQLGDCTVATQASGLLSSKTKPVASVSGQSSGCCITPTGYRAQRGGTSAAQPLNLSQNQQSSSAPTSQERSSNPAPRRQQAFVAPLSQAPYAFQHGSPLHSTGHPHLAPAPAHLPSQPHLYTYAAPTSAAALGPTTSIAHLFSPQGSSRHAAAYATHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL", "length": 1165, "header": "tr|A0AAA9SG61-1|E1BQ34_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=HIPK1 PE=3 SV=1 CANONICAL=E1BQ34-1" }, "locus": { "chromosome": "3", "start_pos": 29439125, "end_pos": 29400234, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133629.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133629.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082653.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082653.1" } ] } }, { "isoform_ac": "A0AAA9TGU1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGU1/entry", "sequence": { "sequence": "MGFSRPISKMFDFMMLFFHILIGMASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSASAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAVIPEAMGSGQQLTDWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPAVSVITIRSDTDEEEDNKYKPNSSGLKARSNVISYVTVNDSPDSDSSLSSPYSTETLSALRGNSGSLPEGPGRVVGDGPGTRTIIVPPLKTQLGDCTVATQASGLLSSKTKPVASVSGQSSGCCITPTGYRAQRGGTSAAQPLNLSQNQQSSSAPTSQERSSNPAPRRQQAFVAPLSQAPYAFQHGSPLHSTGHPHLAPAPAHLPSQPHLYTYAAPTSAAALGPTTSIAHLFSPQGSSRHAAAYATHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL", "length": 1233, "header": "tr|A0AAA9TGU1-1|E1BQ34_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=HIPK1 PE=3 SV=1 CANONICAL=E1BQ34-1" }, "locus": { "chromosome": "3", "start_pos": 29442754, "end_pos": 29400234, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111434.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111434.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096268.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096268.1" } ] } }, { "isoform_ac": "E1BQ34-1", "url": "https://www.uniprot.org/uniprotkb/E1BQ34/entry", "sequence": { "sequence": "MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSASAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAVIPEAMGSGQQLTDWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPAVSVITIRSDTDEEEDNKYKPNSSGLKARSNVISYVTVNDSPDSDSSLSSPYSTETLSALRGNSGSLPEGPGRVVGDGPGTRTIIVPPLKTQLGDCTVATQASGLLSSKTKPVASVSGQSSGCCITPTGYRAQRGGTSAAQPLNLSQNQQSSSAPTSQERSSNPAPRRQQAFVAPLSQAPYAFQHGSPLHSTGHPHLAPAPAHLPSQPHLYTYAAPTSAAALGPTTSIAHLFSPQGSSRHAAAYATHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL", "length": 1210, "header": "tr|E1BQ34-1|E1BQ34_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=HIPK1 PE=3 SV=1 CANONICAL=E1BQ34-1" }, "locus": { "chromosome": "3", "start_pos": 29439125, "end_pos": 29400234, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015051.5", "url": "https://www.ensembl.org/id/ENSBTAT00000015051.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015051.4", "url": "https://www.ensembl.org/id/ENSBTAP00000015051.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1126, "start_aa": "Thr", "end_pos": 1126, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1126", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Li X, Zhang R, Luo D, Park SJ, Wang Q, Kim Y, Min W", "evidence": [ { "database": "RefSeq", "id": "NP_001103468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103468" } ], "reference": [ { "type": "PubMed", "id": "15701637", "url": "https://glygen.org/publication/PubMed/15701637" } ] } ], "pathway": [ { "id": "bta:512233", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512233", "resource": "KEGG Pathway" }, { "id": "R-BTA-6804756", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6804756", "resource": "Reactome", "description": "Regulation of TP53 Activity through Phosphorylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SZC5-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "HIPK1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSASAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAVIPEAMGSGQQLTDWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPNSSGLKARSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGPLPEGPGRVVGDGTGTRTIIVPPLKTQLGDCTVATQASGLLSSKTKPVASVSGQSSGCCITPTGYRAQRGGTSAAQPLNLSQNQQSSSAPTSQERSSNPAPRRQQAFVAPLSQAPYAFQHGSPLHSSGHPHLAPAPAHLPSQPHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSAIYTGYPLSPTKISQYSYL", "length": 1210 }, "evidence": [ { "id": "E1BQ34", "url": "https://omabrowser.org/oma/group/E1BQ34/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1A4V7-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "HIPK1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASQLQVFSPPSVSSSAFCSAKKLKVEPSVWDVSGQSSSDKYYTHSKNLPAAQGQASSSHQVANFSVPAYDQNLLLPAPSVEHIVVTAADSTGSSATASFQNSQTLTHRTNLSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRPAVGAAATTTTVTTKSSNSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPARQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTSRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHPFVTMTHLLDFPHSNHVKSCFQNMEICKRRVNMYDTVNQIKSPFTTHVAPNTSTNLTMSFNNQLNTVHNQASVLASNSTAAATLSLANSDVSLLNYQSALYPSSAAPVAGVAQQSVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMENAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLNCAAGRPALVEQTAAVLAWPGGTQQILLPSTWQQLPGVALHNSVQPAAVIPETIGSSQQLADWRNAHSHGNQYSTLMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSNVPAKKNKQPAPSTAKSSSTLETVPTQVYSLIGSSPLRSTSSSSNVLVPVQEQHQPIVIPDTPSPPVSVITIRSDTDEEEDSKYKPASLGMKQRSNVISYVTVNDSPDSDSSLNSPYATDPLSSLRSTGGALELPSRGAADSSNSRTIIVPPLKTQLNDCIVATQASGILSNTSKTKPVASVSGQSSGCCITPTGYRPHRVVANGVQPLNLSQNQQTTVLASQERSGNAVPRRQQAYVAPLTSTISQAPYTFQHSSPVHPHLAAATANAHLSSQPHMYTYAPTTAATLGSTTSIAHLFSPQGSSRHTQYAAHPSTLVHQVPVSVGPSLLTSANVPPAQYQHQFAPQSYIGASRGSAIYTGYPLSPTKINQYSYL", "length": 1211 }, "evidence": [ { "id": "E1BQ34", "url": "https://omabrowser.org/oma/group/E1BQ34/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A4L9P5-1", "protein_name": "Homeodomain-interacting protein kinase 1", "gene_name": "Hipk1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQASSSHQVANFNIPAYDQGLLLQAPAVEHIVVTAADSSGSAATATFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRVTPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPSTSTNLTMSFSNQLSTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPPSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPLVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVQQAWPGGTQQILLPSAWQQLPGVALHNSVQPTAVIPEAMGSSQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSRKNKQSAPVSSTSSLEVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKFKPSSSSLKARSNVISYVTVNDSPDSDSSLSSPYPTDTLSALRGNSGTLLEGPGRTAADGIGTRTIIVPPLKTQLGDCTGATQASGLLSSSKTKPVASVSGQSSGCCITPTGYRAQRGGASAVQPLNLSQNQQSSSASTSQERSSNPAPRRQQAFVAPLSQAPYAFQHGSPLHSTGHPHLAPAPAHLPSQPHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL", "length": 1211 }, "evidence": [ { "id": "E1BQ34", "url": "https://omabrowser.org/oma/group/E1BQ34/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O88904-1", "protein_name": "Homeodomain-interacting protein kinase 1", "gene_name": "Hipk1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQASSSHQVANFNLPAYDQGLLLPAPAVEHIVVTAADSSGSAATATFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVESNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMSHLLDFPHSSHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSAWQQLPGVALHNSVQPAAVIPEAMGSSQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLEVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPNSSSLKARSNVISYVTVNDSPDSDSSLSSPHPTDTLSALRGNSGTLLEGPGRPAADGIGTRTIIVPPLKTQLGDCTVATQASGLLSSKTKPVASVSGQSSGCCITPTGYRAQRGGASAVQPLNLSQNQQSSSASTSQERSSNPAPRRQQAFVAPLSQAPYAFQHGSPLHSTGHPHLAPAPAHLPSQPHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL", "length": 1210 }, "evidence": [ { "id": "E1BQ34", "url": "https://omabrowser.org/oma/group/E1BQ34/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86Z02-1", "protein_name": "Homeodomain-interacting protein kinase 1", "gene_name": "HIPK1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGTSAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAPLSQAPYTFQHGSPLHSTGHPHLAPAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL", "length": 1210 }, "evidence": [ { "id": "E1BQ34", "url": "https://omabrowser.org/oma/group/E1BQ34/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "E1BQ34", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BQ34", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ], "pmid": "" }, { "name": "protein tyrosine kinase activity", "id": "GO:0004713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004713", "evidence": [ { "database": "UniProtKB", "id": "E1BQ34", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ], "pmid": "" } ] 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"neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "E1BQ34", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ], "pmid": "" }, { "name": "extrinsic apoptotic signaling pathway", "id": "GO:0097191", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097191", "evidence": [ { "database": "UniProtKB", "id": "E1BQ34", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ], "pmid": "" }, { "name": "retina layer formation", "id": "GO:0010842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010842", "evidence": [ { "database": "UniProtKB", "id": "E1BQ34", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ], "pmid": "" }, { "name": "regulation of tumor necrosis factor-mediated signaling pathway", "id": "GO:0010803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010803", "evidence": [ { "database": "UniProtKB", "id": "E1BQ34", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ], "pmid": "" }, { 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"name": "iris morphogenesis", "id": "GO:0061072", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061072", "evidence": [ { "database": "UniProtKB", "id": "E1BQ34", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "id": "GO:0042771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042771", "evidence": [ { "database": "UniProtKB", "id": "E1BQ34", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ], "pmid": "" }, { "name": "smoothened signaling pathway", "id": "GO:0007224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007224", "evidence": [ { "database": "UniProtKB", "id": "E1BQ34", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1045, "end_pos": 1047, "annotation": "n_glycosylation_sequon" }, { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 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"F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "R-BTA-6799431", "name": "TP53 binds HIPK1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BQ34-1" ], "evidence": [ { "id": "R-BTA-6799431", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799431" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + 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ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { 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"uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BQ34-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1210, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BQ34-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BQ34" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 190, "end_pos": 518, "start_aa": "Tyr", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.1", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1" }, { "id": "2.7.11.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1126 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1045, "end_pos": 1047 }, { "start_pos": 111, "end_pos": 113 }, { "start_pos": 133, "end_pos": 135 }, { "start_pos": 149, "end_pos": 151 }, { "start_pos": 262, "end_pos": 264 }, { "start_pos": 471, "end_pos": 473 }, { "start_pos": 566, "end_pos": 568 }, { "start_pos": 570, "end_pos": 572 }, { "start_pos": 57, "end_pos": 59 }, { "start_pos": 923, "end_pos": 925 }, { 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"count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MC18-1", "uniprot_ac": "F1MC18", "uniprot_id": "F1MC18_BOVIN", "mass": { "chemical_mass": 36916.0, "monoisotopic_mass": 36916.0 }, "refseq": { "ac": "NP_001179482", "name": "homeobox protein aristaless-like 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179482" }, "gene_names": [ { "name": "ALX3", "type": "recommended", "evidence": [ { "id": "F1MC18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC18" } ] }, { "name": "ALX3", "type": "synonym", "evidence": [ { "id": "NP_001179482", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179482" } ] } ], "protein_names": [ { "name": "ALX homeobox 3", "type": "synonym", "evidence": [ { "id": "F1MC18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC18/entry#names_and_taxonomy" } ] }, { "name": "aristaless-like homeobox 3", "type": "synonym", "evidence": [ { "id": "NP_001179482", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179482" } ] }, { "name": "homeobox protein aristaless-like 3", "type": "synonym", "evidence": [ { "id": "NP_001179482", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179482" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MC18", "url": "https://www.uniprot.org/uniprotkb/F1MC18" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ALX3", "url": "https://www.uniprot.org/uniprotkb/F1MC18", "locus": { "chromosome": "3", "start_pos": 33370814, "end_pos": 33360421, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020966", "url": "https://www.ensembl.org/id/ENSBTAG00000020966" } ] } } ], "crossref": [ { "id": "F1MC18", "url": "https://alphafold.ebi.ac.uk/entry/F1MC18", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020966", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020966", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522085", "url": "https://www.ncbi.nlm.nih.gov/gene/522085", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050649", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050649", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522085", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522085", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GSHFYEG", "url": "https://omabrowser.org/oma/group/GSHFYEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MC18", "url": "https://www.orthodb.org/?gene=F1MC18", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24329", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24329", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24329:SF578", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24329:SF578", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179482", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SI03", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI03-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI03-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC18", "url": "https://www.uniprot.org/uniprotkb/F1MC18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC18-1", "url": "https://www.uniprot.org/uniprotkb/F1MC18-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPERCAPFGVGPGPGPYAAAGDEPPGPQGTPAAASHLHPAPPRGPRLTRFPACGPLEPYLPEPAKPPAKYLQDLGPGPALNGGHFYESPEEAEEKASKAASFPQLPLDCRGGPRDGTSNLPGSPGPCLASLRVPLSPGLPDSMELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLAVRTDLTEARVQVWFQNRRAKWRKRERYGKIQEGRNPFTSAYDISMLPRTDSHPQLQNSLWPSSGSGSPGGPCLVSPEGVPSPCMSPYSHPHGNVAGFMGVPTSPGAHPGIYSIHGFSPALGGHSFEPSPDGDYKSPSLISLRVKPKEPPSLLNWTT", "length": 343, "header": "tr|F1MC18-1|F1MC18_BOVIN Isoform 1 of ALX homeobox 3 OS=Bos taurus OX=9913 GN=ALX3 PE=3 SV=3 CANONICAL=F1MC18-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SI03-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI03/entry", "sequence": { "sequence": "MKNERIKSGGGSKEEGKWRRGERTKREAADNMKKKKHPKSAENSKMGTSRRRKLTMRVEQRTDQTKWRRGGCEPKLAEEKASKAASFPQLPLDCRGGPRDGTSNLPGSPGPCLASLRVPLSPGLPDSMELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLAVRTDLTEARVQVWFQNRRAKWRKRERYGKIQEGRNPFTSAYDISMLPRTDSHPQLQNSLWPSSGSGSPGGPCLVSPEGVPSPCMSPYSHPHGNVAGFMGVPTSPGAHPGIYSIHGFSPALGGHSFEPSPDGDYKSPSLISLRVKPKEPPSLLNWTT", "length": 327, "header": "tr|A0AAA9SI03-1|F1MC18_BOVIN Computationally mapped isoform of ALX homeobox 3 OS=Bos taurus OX=9913 GN=ALX3 PE=3 SV=1 CANONICAL=F1MC18-1" }, "locus": { "chromosome": "3", "start_pos": 33369810, "end_pos": 33362329, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000123482.1", "url": "https://www.ensembl.org/id/ENSBTAT00000123482.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084970.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084970.1" } ] } }, { "isoform_ac": "F1MC18-1", "url": "https://www.uniprot.org/uniprotkb/F1MC18/entry", "sequence": { "sequence": "MDPERCAPFGVGPGPGPYAAAGDEPPGPQGTPAAASHLHPAPPRGPRLTRFPACGPLEPYLPEPAKPPAKYLQDLGPGPALNGGHFYESPEEAEEKASKAASFPQLPLDCRGGPRDGTSNLPGSPGPCLASLRVPLSPGLPDSMELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLAVRTDLTEARVQVWFQNRRAKWRKRERYGKIQEGRNPFTSAYDISMLPRTDSHPQLQNSLWPSSGSGSPGGPCLVSPEGVPSPCMSPYSHPHGNVAGFMGVPTSPGAHPGIYSIHGFSPALGGHSFEPSPDGDYKSPSLISLRVKPKEPPSLLNWTT", "length": 343, "header": "tr|F1MC18-1|F1MC18_BOVIN Isoform 1 of ALX homeobox 3 OS=Bos taurus OX=9913 GN=ALX3 PE=3 SV=3 CANONICAL=F1MC18-1" }, "locus": { "chromosome": "3", "start_pos": 33369810, "end_pos": 33360536, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027924.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027924.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027924.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027924.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 31, "start_aa": "Thr", "end_pos": 31, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr31", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:522085", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522085", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LN97-1", "protein_name": "ALX homeobox 3", "gene_name": "Alx3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDPERCAPFAVGPAAGPYAAARDEAPGPQGTPDAAPHLRPAPPRGPRLSRFPACGPLEPYLPEPAKPPAKYLQDLGPGPVLNGGHFYKGSSEAEEKASKAASFPQLPVDCRGGPRDGPSNVQGSPGPCLASLSVPLSPGLPDSMELAKSKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKIQEGRNPFTTAYDISVLPRTDSHPQLQNSLWSSPGSGSPGGPCLMPPEGIPSPCMSPYSHSHGNVAGFMGVPASPAAHPGIYSIHGFPPALGGHSFEPSPDGDYKSPSLVSLRMKPKEPPSLLNWTT", "length": 343 }, "evidence": [ { "id": "F1MC18", "url": "https://omabrowser.org/oma/group/F1MC18/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S615-1", "protein_name": "ALX homeobox 3", "gene_name": "ALX3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDPERCAPFGVGPESGPYAAAGDEPPGPQRTPAAAPHLHPAPPRGPRLTRFPACGPLEPYLPEPAKPPAKYLQDLGPGPALNGGHFYEGPAEAEEKASKAASFPQLPLDCRGGPRDGPSNLPGSPGPCLASLRVPLSPGLPDSMELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKIQEGRNPFTSAYDISVLPRTDSHPQLQNALWPSPGSGSPGGPCLVSPEGIPSPCMSPYPHSHGNVAGFMGVPASPGAPPSIYSIHSFSPALGAHSFEPSPDGDYKSPSLISLRVKPKEPPNLLNWTT", "length": 343 }, "evidence": [ { "id": "F1MC18", "url": "https://omabrowser.org/oma/group/F1MC18/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O70137-1", "protein_name": "Homeobox protein aristaless-like 3", "gene_name": "Alx3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPERCAPFSVGPAAGPYAAAGDEAPGPQGTPDAAPHLHPAPPRGPRLSRFPACGPLEPYLPEPAKPPAKYLQDLGPGPVLNGGHFYEGSAEAEEKASKAASFPQLPVDCRGGPRDGPSNVQASPGPCLASLSVPLSPGLPDSMELAKTKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKMQEGRNPFTTAYDISVLPRTDSHPQLQNSLWPSPGSGSPGGPCLMSPEGIPSPCMSPYSHSHGNVAGFMGVPASPAAHPGIYSIHGFPPALGGHSFEPSPDGDYKSPSLVSLRMKPKEPPGLLNWTT", "length": 343 }, "evidence": [ { "id": "F1MC18", "url": "https://omabrowser.org/oma/group/F1MC18/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O95076-1", "protein_name": "Homeobox protein aristaless-like 3", "gene_name": "ALX3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPEHCAPFRVGPAPGPYVASGDEPPGPQGTPAAAPHLHPAPPRGPRLTRFPACGPLEPYLPEPAKPPAKYLQDLGPGPALNGGHFYEGPAEAEEKTSKAASFPQLPLDCRGGPRDGPSNLQGSPGPCLASLHLPLSPGLPDSMELAKNKSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRERYGKIQEGRNPFTAAYDISVLPRTDSHPQLQNSLWASPGSGSPGGPCLVSPEGIPSPCMSPYSHPHGSVAGFMGVPAPSAAHPGIYSIHGFPPTLGGHSFEPSSDGDYKSPSLVSLRVKPKEPPGLLNWTT", "length": 343 }, "evidence": [ { "id": "F1MC18", "url": "https://omabrowser.org/oma/group/F1MC18/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MC18", "url": "https://www.uniprot.org/uniprotkb/F1MC18" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1MC18", "url": "https://www.uniprot.org/uniprotkb/F1MC18" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "F1MC18", "url": "https://www.uniprot.org/uniprotkb/F1MC18" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MC18", "url": "https://www.uniprot.org/uniprotkb/F1MC18" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MC18", "url": "https://www.uniprot.org/uniprotkb/F1MC18" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MC18", "url": "https://www.uniprot.org/uniprotkb/F1MC18" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "F1MC18", "url": "https://www.uniprot.org/uniprotkb/F1MC18" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 340, "end_pos": 342, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MC18-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 343, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MC18-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MC18" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MC18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC18" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 151, "end_pos": 211, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 31 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 149, "end_pos": 151 }, { "start_pos": 156, "end_pos": 158 }, { "start_pos": 340, "end_pos": 342 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MD94-1", "uniprot_ac": "F1MD94", "uniprot_id": "F1MD94_BOVIN", "mass": { "chemical_mass": 52524.0, "monoisotopic_mass": 52524.0 }, "refseq": { "ac": "XP_015329057", "name": "matrilin-3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329057" }, "gene_names": [ { "name": "MATN3", "type": "recommended", "evidence": [ { "id": "F1MD94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD94" } ] }, { "name": "MATN3", "type": "synonym", "evidence": [ { "id": "XP_015329057", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329057" } ] } ], "protein_names": [ { "name": "Matrilin-3", "type": "recommended", "evidence": [ { "id": "F1MD94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD94/entry#names_and_taxonomy" } ] }, { "name": "matrilin-3", "type": "synonym", "evidence": [ { "id": "XP_015329057", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329057" } ] } ], "function": [ { "annotation": "Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.", "evidence": [ { "database": "UniProtKB", "id": "F1MD94", "url": "https://www.uniprot.org/uniprotkb/F1MD94#function" }, { "database": "UniProtKB", "id": "ARBA00056017", "url": "https://www.uniprot.org/uniprotkb/ARBA00056017#function" }, { "database": "UniProtKB", "id": "A0AAA9SIL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL5#function" }, { "database": "UniProtKB", "id": "A0AAA9THC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THC1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MD94", "url": "https://www.uniprot.org/uniprotkb/F1MD94" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MATN3", "url": "https://www.uniprot.org/uniprotkb/F1MD94", "locus": { "chromosome": "11", "start_pos": 78841622, "end_pos": 78823423, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020893", "url": "https://www.ensembl.org/id/ENSBTAG00000020893" } ] } } ], "crossref": [ { "id": "F1MD94", "url": "https://alphafold.ebi.ac.uk/entry/F1MD94", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020893", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020893", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540041", "url": "https://www.ncbi.nlm.nih.gov/gene/540041", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "F1MD94", "url": "https://www.ebi.ac.uk/intact/interactors/id:F1MD94*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540041", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540041", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MD94", "url": "https://www.orthodb.org/?gene=F1MD94", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24020", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24020", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24020:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24020:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10393", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10393", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14670", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14670", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_015329057", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015329057", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SIL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THC1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MD94", "url": "https://www.uniprot.org/uniprotkb/F1MD94", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MD94-1", "url": "https://www.uniprot.org/uniprotkb/F1MD94-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRHLPGLLLLLWPLLLLPPPPAAPSPMARPGLRRLGTRGPGGSPGRRGPAPAAPASVPYSGTGQPGGARGAGVCKSRPLDLVFIIDSSRSVRPLQFTKVKTFVSKIIDTLDIGPMDTRVAVVNYASTVKIEFHLQTHSDKQSLKRAVARITPLSTGTMSGLAIQTAMDEAFTVEAGARGPSSNIPKVAIIVTDGRPQDQVNEVAARARASGIELYAVGVDRADMESLKMMASEPLDEHVFYVETYGVIEKLSSRFQETFCALDPCALGTHQCQHVCISDGEGRHHCECSQGYSLNADKKTCSAIDKCALNTHGCEHICVNDRTGSYHCECYEGYTLNEDRKTCSAQDQCALGTHGCQHICVNDRAGSHHCECYEGYTLNEDKKTCSVLNQCALGSHGCQHICVYDGNASYHCDCDTGYTLNEDKKTCSAIEEARRLISTEDACACEATLAFQDKVNSYLQRLNSKLDDILEKLQANEYGQVHR", "length": 484, "header": "tr|F1MD94-1|F1MD94_BOVIN Isoform 1 of Matrilin-3 OS=Bos taurus OX=9913 GN=MATN3 PE=4 SV=3 CANONICAL=F1MD94-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIL5/entry", "sequence": { "sequence": "MPRHLPGLLLLLWPLLLLPPPPAAPSPMARPGLRRLGTRGPGGSPGRRGPAPAAPASVPYSGTGQPGGARGAGVCKSRPLDLVFIIDSSRSVRPLQFTKVKTFVSKIIDTLDIGPMDTRVAVVNYASTVKIEFHLQTHSDKQSLKRAVARITPLSTGTMSGLAIQTAMDEAFTVEAGARGPSSNIPKVAIIVTDGRPQDQVNEVAARARASGIELYAVGVDRADMESLKMMASEPLDEHVFYVETYGVIEKLSSRFQETFCAIDKCALNTHGCEHICVNDRTGSYHCECYEGYTLNEDRKTCSAQDQCALGTHGCQHICVNDRAGSHHCECYEGYTLNEDKKTCSVLNQCALGSHGCQHICVYDGNASYHCDCDTGYTLNEDKKTCSAIEEARRLISTEDACACEATLAFQDKVNSYLQRLNSKLDDILEKLQANEYGQVHR", "length": 442, "header": "tr|A0AAA9SIL5-1|F1MD94_BOVIN Computationally mapped isoform of Matrilin-3 OS=Bos taurus OX=9913 GN=MATN3 PE=4 SV=1 CANONICAL=F1MD94-1" }, "locus": { "chromosome": "11", "start_pos": 78841619, "end_pos": 78823440, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133329.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133329.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082390.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082390.1" } ] } }, { "isoform_ac": "A0AAA9THC1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THC1/entry", "sequence": { "sequence": "MPRHLPGLLLLLWPLLLLPPPPAAPSPMARPGLRRLGTRGPGGSPGRRGPAPAAPASVPYSGTGQPGGARGAGVCKSRPLDLVFIIDSSRSVRPLQFTKVKTFVSKIIDTLDIGPMDTRVAVVNYASTVKIEFHLQTHSDKQSLKRAVARITPLSTGTMSGLAIQTAMDEAFTVEAGARGPSSNIPKVAIIVTDGRPQDQVNEVAARARASGIELYAVGVDRADMESLKMMASEPLDEHVFYVETYGVIEKLSSRFQETFCALDPCALGTHQCQHVCISDGEGRHHCECSQGYSLNADKKTCSAIDKCALNTHGCEHICVNDRTGSYHCECYEGYTLNEDRKTCSAQDQCALGTHGCQHICVNDRAGSHHCECYEGYTLNEDKKTCSVLNQCALGSHGCQHICVYDGNASYHCDCDTGYTLNEDKKTCSAIEEARRLISTEDACACEATLAFQDKVNSYLQRLNSKHILFGRISTSA", "length": 477, "header": "tr|A0AAA9THC1-1|F1MD94_BOVIN Computationally mapped isoform of Matrilin-3 OS=Bos taurus OX=9913 GN=MATN3 PE=4 SV=1 CANONICAL=F1MD94-1" }, "locus": { "chromosome": "11", "start_pos": 78838768, "end_pos": 78823440, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097002.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097002.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096269.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096269.1" } ] } }, { "isoform_ac": "F1MD94-1", "url": "https://www.uniprot.org/uniprotkb/F1MD94/entry", "sequence": { "sequence": "MPRHLPGLLLLLWPLLLLPPPPAAPSPMARPGLRRLGTRGPGGSPGRRGPAPAAPASVPYSGTGQPGGARGAGVCKSRPLDLVFIIDSSRSVRPLQFTKVKTFVSKIIDTLDIGPMDTRVAVVNYASTVKIEFHLQTHSDKQSLKRAVARITPLSTGTMSGLAIQTAMDEAFTVEAGARGPSSNIPKVAIIVTDGRPQDQVNEVAARARASGIELYAVGVDRADMESLKMMASEPLDEHVFYVETYGVIEKLSSRFQETFCALDPCALGTHQCQHVCISDGEGRHHCECSQGYSLNADKKTCSAIDKCALNTHGCEHICVNDRTGSYHCECYEGYTLNEDRKTCSAQDQCALGTHGCQHICVNDRAGSHHCECYEGYTLNEDKKTCSVLNQCALGSHGCQHICVYDGNASYHCDCDTGYTLNEDKKTCSAIEEARRLISTEDACACEATLAFQDKVNSYLQRLNSKLDDILEKLQANEYGQVHR", "length": 484, "header": "tr|F1MD94-1|F1MD94_BOVIN Isoform 1 of Matrilin-3 OS=Bos taurus OX=9913 GN=MATN3 PE=4 SV=3 CANONICAL=F1MD94-1" }, "locus": { "chromosome": "11", "start_pos": 78841619, "end_pos": 78823440, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027836.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027836.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027836.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027836.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540041", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540041", "resource": "KEGG Pathway" }, { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MD94", "url": "https://www.uniprot.org/uniprotkb/F1MD94" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "F1MD94", "url": "https://www.uniprot.org/uniprotkb/F1MD94" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MD94", "url": "https://www.uniprot.org/uniprotkb/F1MD94" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "skeletal system development", "id": "GO:0001501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001501", "evidence": [ { "database": "UniProtKB", "id": "F1MD94", "url": "https://www.uniprot.org/uniprotkb/F1MD94" } ], "pmid": "" }, { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "F1MD94", "url": "https://www.uniprot.org/uniprotkb/F1MD94" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 408, "end_pos": 410, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MD94-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 484, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MD94-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MD94" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MD94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD94" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 262, "end_pos": 303, "start_aa": "Ala", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MD94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD94" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 81, "end_pos": 256, "start_aa": "Asp", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 408, "end_pos": 410 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MH69-1", "uniprot_ac": "F1MH69", "uniprot_id": "F1MH69_BOVIN", "mass": { "chemical_mass": 41608.0, "monoisotopic_mass": 41608.0 }, "refseq": {}, "gene_names": [ { "name": "TM6SF1", "type": "recommended", "evidence": [ { "id": "F1MH69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH69" } ] } ], "protein_names": [ { "name": "Transmembrane 6 superfamily member 1", "type": "recommended", "evidence": [ { "id": "F1MH69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH69/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May function as sterol isomerase.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SK54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK54#function" }, { "database": "UniProtKB", "id": "ARBA00037773", "url": "https://www.uniprot.org/uniprotkb/ARBA00037773#function" }, { "database": "UniProtKB", "id": "F1MH69", "url": "https://www.uniprot.org/uniprotkb/F1MH69#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MH69", "url": "https://www.uniprot.org/uniprotkb/F1MH69" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TM6SF1", "url": "https://www.uniprot.org/uniprotkb/F1MH69", "locus": { "chromosome": "21", "start_pos": 24920143, "end_pos": 24951743, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012926", "url": "https://www.ensembl.org/id/ENSBTAG00000012926" } ] } } ], "crossref": [ { "id": "F1MH69", "url": "https://alphafold.ebi.ac.uk/entry/F1MH69", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012926", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012926", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21106", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21106", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR033118", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033118", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FFMKPKQ", "url": "https://omabrowser.org/oma/group/FFMKPKQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MH69", "url": "https://www.orthodb.org/?gene=F1MH69", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14568", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14568", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14568:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14568:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05241", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05241", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26083", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26083", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SK54", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SK54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK54-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH69", "url": "https://www.uniprot.org/uniprotkb/F1MH69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH69-1", "url": "https://www.uniprot.org/uniprotkb/F1MH69-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSASAATGVFVLSLSAIPVTYVFNHLAAQHDSWTIVGAAAVVLLLVALLARVLVKRKPPRDPLFYVYAVFGFTSVVNLIIGLEQDGIIDGFMTHYLREGEPYLNTAYGHMICYWDGSAHYLMYLVMVAAIAWEESYRTIGLYWVGSIIMSIVVFVPGNIVGKYGTRICPAFFLSIPYTCLPVWAGFRIYNQPSENYNYPSKVIQEVQAKDLLRRPFDLILVLCLLLATGFCVFRGLIALDCPAELCRLYTQFQEPYLKDPAAYPKIQMLAYLFYSVPYFVIALYGLVVPGCFWMPDITLIHAGGLAQAQFSHIGASLHARTAYVYRVPEEAKIIFLALNIAYGVLPQLLAYRCIYRPEFFIKTKADEKVE", "length": 370, "header": "tr|F1MH69-1|F1MH69_BOVIN Isoform 1 of Transmembrane 6 superfamily member 1 OS=Bos taurus OX=9913 GN=TM6SF1 PE=3 SV=1 CANONICAL=F1MH69-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SK54-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK54/entry", "sequence": { "sequence": "MSASAATGVFVLSLSAIPVTYVFNHLAAQHDSWTIVGAAAVVLLLVALLARVLVKRKPPRDPLFYVYAVFGFTSVVNLIIGLEQDGIIDGFMTHYLREGEPYLNTAYGHMICYWDGSAHYLMYLVMVAAIAWEESYRTIGLYWVGSIIMSIVVFVPGNIVGKYGTRICPAFFLSIPYTCLPVWAGFRIYNQPSENYNYPSKVIQEVQAKDLLRRPFDLILVLCLLLATGFCVFRGLIALDCPAELCRLYTQFQEPYLKDPAAYPKIQMLAYLFYSVPYFVIALYGLVVPGCFWMPDITLIHAGGLAQLVTKIRKPKRKWCPDQCMDNVQCEFRGPLNCKLFNYKPRIRERCSKDKHNRIDKTQTD", "length": 365, "header": "tr|A0AAA9SK54-1|F1MH69_BOVIN Computationally mapped isoform of Transmembrane 6 superfamily member 1 OS=Bos taurus OX=9913 GN=TM6SF1 PE=3 SV=1 CANONICAL=F1MH69-1" }, "locus": { "chromosome": "21", "start_pos": 24951719, "end_pos": 24921092, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111256.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111256.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085685.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085685.1" } ] } }, { "isoform_ac": "F1MH69-1", "url": "https://www.uniprot.org/uniprotkb/F1MH69/entry", "sequence": { "sequence": "MSASAATGVFVLSLSAIPVTYVFNHLAAQHDSWTIVGAAAVVLLLVALLARVLVKRKPPRDPLFYVYAVFGFTSVVNLIIGLEQDGIIDGFMTHYLREGEPYLNTAYGHMICYWDGSAHYLMYLVMVAAIAWEESYRTIGLYWVGSIIMSIVVFVPGNIVGKYGTRICPAFFLSIPYTCLPVWAGFRIYNQPSENYNYPSKVIQEVQAKDLLRRPFDLILVLCLLLATGFCVFRGLIALDCPAELCRLYTQFQEPYLKDPAAYPKIQMLAYLFYSVPYFVIALYGLVVPGCFWMPDITLIHAGGLAQAQFSHIGASLHARTAYVYRVPEEAKIIFLALNIAYGVLPQLLAYRCIYRPEFFIKTKADEKVE", "length": 370, "header": "tr|F1MH69-1|F1MH69_BOVIN Isoform 1 of Transmembrane 6 superfamily member 1 OS=Bos taurus OX=9913 GN=TM6SF1 PE=3 SV=1 CANONICAL=F1MH69-1" }, "locus": { "chromosome": "21", "start_pos": 24951719, "end_pos": 24922778, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017175.5", "url": "https://www.ensembl.org/id/ENSBTAT00000017175.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017175.4", "url": "https://www.ensembl.org/id/ENSBTAP00000017175.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D4A3E7-1", "protein_name": "Transmembrane 6 superfamily member 1", "gene_name": "Tm6sf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSASAATGVFVLSLSAIPVTYIFNHLAAQHDSWTIVGVAALILLLVALLARVLVRRKPPRDPLFYVYAVFGFTSVVNLIIGLEQDGIIDGFMTHYLREGEPYLNTAYGHMICYWDGSVHYLMYLVMVAAIAWEESYRTIGLYWVGSIIMSIVVFVPGNIVGKYGTRICPAFFLSIPYTCLPVWAGFRIYNQPSENYNYPSKVLQEAQAKTLLRRPFDLVLVMCLFLATGFCLFRGLIALDCPAELCRLYTQFQEPYLKDPAAYPKIQMLAYMFYSVPYFVIALYGLVVPGCSWMPDITLVHAGGLAQAQFSHIGASLHARTAYVYRVPEEAKIFFLALNVAYGVLPQLLAYRCTYSPEFFIRTKADEKLE", "length": 370 }, "evidence": [ { "id": "F1MH69", "url": "https://omabrowser.org/oma/group/F1MH69/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1N951-1", "protein_name": "Transmembrane 6 superfamily member 1", "gene_name": "TM6SF1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSASAATGVFVLSLTAIPVTYLFNCLAAGGSSWSIVAVGLLVLVFIALLARVLVKRKPPKDPLFYVYAVFAFTSVVNLIIGLEQDGIIDGFMTHYLREGEPYLNTAYGHVICYWDGSVHYLMYLLMVAAIAWEQSYRTIGLYWLGSIFMSIIVFMPGNIVGKYGTKVCPAFFLSVPYICLPIWAGFRIYNQPSATHDTPVKVVQEVQKKGLLRRPVDLMLAAYLILAAGFCIFRGMIALDCPAELCRLYIQLHEPYIKDPAAYPKLQMLAYMFYSVPYYVIALYGLLVPGCSWMPDLTLIHAGGLAQAQFSHIGASLHARTPYIYRVPEEAKQFFLILNIMYGILPQLLAYRCVNKPEFFMKAKEEEKTE", "length": 370 }, "evidence": [ { "id": "F1MH69", "url": "https://omabrowser.org/oma/group/F1MH69/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P58749-1", "protein_name": "Transmembrane 6 superfamily member 1", "gene_name": "Tm6sf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSASAATGVFVLSLSAIPVTYIFNHLAAQHDSWTIVGVAALILLLVALLARVLVRRKPPRDPLFYVYAVFGFTSVVNLIIGLEQDGIIDGFMTHYLREGEPYLNTAYGHMICYWDGSVHYLMYLVMVAAIAWEESYRTIGLYWVGSIIMSIVVFVPGNIVGKYGTRICPAFFLSIPYTCLPVWAGFRIYNQPSENYNYPSKVLQEAQAKALLRRPFDLVLVLCLFLATGFCLFRGLIALDCPAELCRLYTQFQEPYLKDPAAYPKIQMLAYMFYSVPYFVIALYGLVVPGCSWMPDITLVHAGGLAQAQFSHIGASLHARTAYVYRVPEEAKIFFLALNIAYGVLPQLLAYRCTYNPEFFLRTKADEKLE", "length": 370 }, "evidence": [ { "id": "F1MH69", "url": "https://omabrowser.org/oma/group/F1MH69/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BZW5-1", "protein_name": "Transmembrane 6 superfamily member 1", "gene_name": "TM6SF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSASAATGVFVLSLSAIPVTYVFNHLAAQHDSWTIVGVAALILFLVALLARVLVKRKPPRDPLFYVYAVFGFTSVVNLIIGLEQDGIIDGFMTHYLREGEPYLNTAYGHMICYWDGSAHYLMYLVMVAAIAWEETYRTIGLYWVGSIIMSVVVFVPGNIVGKYGTRICPAFFLSIPYTCLPVWAGFRIYNQPSENYNYPSKVIQEAQAKDLLRRPFDLMLVVCLLLATGFCLFRGLIALDCPSELCRLYTQFQEPYLKDPAAYPKIQMLAYMFYSVPYFVTALYGLVVPGCSWMPDITLIHAGGLAQAQFSHIGASLHARTAYVYRVPEEAKILFLALNIAYGVLPQLLAYRCIYKPEFFIKTKAEEKVE", "length": 370 }, "evidence": [ { "id": "F1MH69", "url": "https://omabrowser.org/oma/group/F1MH69/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "F1MH69", "url": "https://www.uniprot.org/uniprotkb/F1MH69" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MH69-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 370, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MH69-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MH69" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MH69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH69" }, { "id": "PS51751", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51751" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EXPERA", "eco_id": "ECO_0000259", "start_pos": 60, "end_pos": 185, "start_aa": "Arg", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MEY1-1", "uniprot_ac": "F1MEY1", "uniprot_id": "F1MEY1_BOVIN", "mass": { "chemical_mass": 164755.0, "monoisotopic_mass": 164755.0 }, "refseq": { "ac": "NP_001193679", "name": "ATPase family AAA domain-containing protein 2B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193679" }, "gene_names": [ { "name": "ATAD2B", "type": "recommended", "evidence": [ { "id": "F1MEY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEY1" } ] }, { "name": "ATAD2B", "type": "synonym", "evidence": [ { "id": "NP_001193679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193679" } ] } ], "protein_names": [ { "name": "ATPase family AAA domain containing 2B", "type": "synonym", "evidence": [ { "id": "F1MEY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEY1/entry#names_and_taxonomy" } ] }, { "name": "ATPase family AAA domain-containing protein 2B", "type": "synonym", "evidence": [ { "id": "NP_001193679", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193679" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MEY1", "url": "https://www.uniprot.org/uniprotkb/F1MEY1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ATAD2B", "url": "https://www.uniprot.org/uniprotkb/F1MEY1", "locus": { "chromosome": "11", "start_pos": 75213880, "end_pos": 75091774, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017255", "url": "https://www.ensembl.org/id/ENSBTAG00000017255" } ] } } ], "crossref": [ { "id": "ENSBTAG00000017255", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017255", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05528", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05528", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19517", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19517", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518785", "url": "https://www.ncbi.nlm.nih.gov/gene/518785", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045199", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045199", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518785", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518785", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DKQCTTN", "url": "https://omabrowser.org/oma/group/DKQCTTN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MEY1", "url": "https://www.orthodb.org/?gene=F1MEY1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23069", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23069", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23069:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23069:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00004", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00004", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00439", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00439", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17862", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17862", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193679", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SKQ9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SML1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SML1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SML1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SML1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEY1", "url": "https://www.uniprot.org/uniprotkb/F1MEY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEY1-1", "url": "https://www.uniprot.org/uniprotkb/F1MEY1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVNTRKSSLRLLGSKSPGPGPGPGAGVEPGATGGSSHFISSRTRSSKTRAASCPAAKAGGSGSAGVALDEARKAEADGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRTTGQREEWNISSGQARLTSQPGATLPNGHSSLSLRSHPHRGEKKGDGELSCINGDMEVRKSCRSRKNRFESVNQSLLFDQLVNSTAEAVLQEMDNINIRRNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKSLRRNSYGIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSDTTSSDEERFERRKSKSMARARNRCLPMNLRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLNAQDFYHAMQNIVPASQRAVMSSGHALSPIIKPLLERSFNNILAVLQKVFPHAEISQSDKKEDIETLILDDSEDENALSIFETSCHSGSPKKQSSAAAVHKPYLHFTMSPYHQPTSYRPRLLLSGERGSGQTSHLAPALLHTLEKFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPHIGDWWEAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYIQRPIEEDRRKFFQELILNQASMAPPRRKHTGLCAMEVLPLALPSPPRQLSESEKIRMEDQEENTLRELRLFLRDVTKRLATDKRFNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKHNYLTAKDFLKDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKEARIKRGLSVTAEQINPHGTGARKTETRVEEAFRHKQRNPMDVWHSSANKCAFRVRRKSRRRSQWGKGIIKKRKVNNLKKDEDDTKFTDYENHMEDRKLLENGEFEVSTDCHEENGEETGDLSMTNDESSCDIMDMDQGQRLNNGASTKENFASTEEESSNESLLINSSSSLNPEQTSRKEPFLKEGCLNGEASTDSFEGIPVLECQNGKAEVVSCCGSGDKCSSEQKTLLEDQSKEKPETSNENHGDDPEKLEALECSTNEKLEPGPDVEVKDAELDKEGASKVKKYRKLILEQAKTTSLELVPEEPSEPVPPLIVDHERLKKLLDLLVDKSNNLAVDQLERLYSLLSQCIYRHRKDYDKSQLVEEMERTVHMFETFL", "length": 1458, "header": "tr|F1MEY1-1|F1MEY1_BOVIN Isoform 1 of ATPase family AAA domain containing 2B OS=Bos taurus OX=9913 GN=ATAD2B PE=3 SV=3 CANONICAL=F1MEY1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKQ9/entry", "sequence": { "sequence": "MVNTRKSSLRLLGSKSPGPGPGPGAGVEPGATGGSSHFISSRTRSSKTRAASCPAAKAGGSGSAGVALDEARKAEADGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRTTGQREEWNISSGQARLTSQPGATLPNGHSSLSLRSHPHRGEKKGDGELSCINGDMEVRKSCRSRKNRFESVNQSLLFDQLVNSTAEAVLQEMDNINIRRNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKSLRRNSYGIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSDTTSSDEERFERRKSKSMARARNRCLPMNLRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLNAQDFYHAMQNIVPASQRAVMSSGHALSPIIKPLLERSFNNILAVLQKVFPHAEISQSDKKEDIETLILDDSEDENALSIFETSCHSGSPKKQSSAAAVHKPYLHFTMSPYHQPTSYRPRLLLSGERGSGQTSHLAPALLHTLEKFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPHIGDWWEAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYIQRPIEEDRRKFFQELILNQASMAPPRRKHTGLCAMEVLPLALPSPPRQLSESEKIRMEDQEENTLRELRLFLRDVTKRLATDKRFNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKHNYLTAKDFLKDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKEARIKRGLSVTAEQINPHGTGARKTETRVEEAFRHKQRNPMDVWHSSANKCAFRVRRKSRRRSQWGKGIIKKRKVNNLKKDEDDTKFTDYENHMEDRKLLENGEFEVSTDCHEENGEETGDLSMTNDESSCDIMDMDQGQRLNNGASTKENFASTEEESSNESLLINSSSSLNPEQTSRKEPFLKEGCLNGEASTDSFEGIPVLECQNGKAEVVSCCGSGDKCSSEQKTLLEDQSKEKPETSNENHGDDPEKLEALECSTNEKLEPGPDVEVKDAELDKEGASKVKKYRKLILEQAKTTSLELVPEEPSEPVPPLIVDHERLKKLLDLLVDKSNNLAVDQLERLYSLLSQCIYRHRKDYDKSQLVENRSNLGFFVYQNTEIHGWQTHGIAWRSSPLPCFSATSQMMRITWAC", "length": 1491, "header": "tr|A0AAA9SKQ9-1|F1MEY1_BOVIN Computationally mapped isoform of ATPase family AAA domain containing 2B OS=Bos taurus OX=9913 GN=ATAD2B PE=3 SV=1 CANONICAL=F1MEY1-1" }, "locus": { "chromosome": "11", "start_pos": 75207784, "end_pos": 75091973, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098013.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098013.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085874.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085874.1" } ] } }, { "isoform_ac": "A0AAA9SML1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SML1/entry", "sequence": { "sequence": "MVNTRKSSLRLLGSKSPGPGPGPGAGVEPGATGGSSHFISSRTRSSKTRAASCPAAKAGGSGSAGVALDEARKAEADGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRTTGQREEWNISSGQARLTSQPGATLPNGHSSLSLRSHPHRGEKKGDGELSCINGDMEVRKSCRSRKNRFESVNQSLLFDQLVNSTAEAVLQEMDNINIRRNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKSLRRNSYGIQNHHEVSTEGEEEARTSILLPLEKISIESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSDTTSSDEERFERRKSKSMARARNRCLPMNLRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLNAQDFYHAMQNIVPASQRAVMSSGHALSPIIKPLLERSFNNILAVLQKVFPHAEISQSDKKEDIETLILDDSEDENALSIFETSCHSGSPKKQSSAAAVHKPYLHFTMSPYHQPTSYRPRLLLSGERGSGQTSHLAPALLHTLEKFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPHIGDWWEAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYIQRPIEEDRRKFFQELILNQASMAPPRRKHTGLCAMEVLPLALPSPPRQLSESEKIRMEDQEENTLRELRLFLRDVTKRLATDKRFNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKHNYLTAKDFLKDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKEARIKRGLSVTAEQINPHGTGARKTETRVEEAFRHKQRNPMDVWHSSANKCAFRVRRKSRRRSQWGKGIIKKRKVNNLKKDEDDTKFTDYENHMEDRKLLENGEFEVSTDCHEENGEETGDLSMTNDESSCDIMDMDQGQRLNNGASTKENFASTEEESSNESLLINSSSSLNPEQTSRKEPFLKEGCLNGEASTDSFEGIPVLECQNGKAEVVSCCGSGDKCSSEQKTLLEDQSKEKPETSNENHGDDPEKLEALECSTNEKLEPGPDVEVKDAELDKEGASKVKKYRKLILEQAKTTSLELVPEEPSEPVPPLIVDHERLKKLLDLLVDKSNNLAVDQLERLYSLLSQCIYRHRKDYDKSQLVEEMERTVHMFETFL", "length": 1472, "header": "tr|A0AAA9SML1-1|F1MEY1_BOVIN Computationally mapped isoform of ATPase family AAA domain containing 2B OS=Bos taurus OX=9913 GN=ATAD2B PE=3 SV=1 CANONICAL=F1MEY1-1" }, "locus": { "chromosome": "11", "start_pos": 75210465, "end_pos": 75091973, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129238.2", "url": "https://www.ensembl.org/id/ENSBTAT00000129238.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086547.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086547.1" } ] } }, { "isoform_ac": "F1MEY1-1", "url": "https://www.uniprot.org/uniprotkb/F1MEY1/entry", "sequence": { "sequence": "MVNTRKSSLRLLGSKSPGPGPGPGAGVEPGATGGSSHFISSRTRSSKTRAASCPAAKAGGSGSAGVALDEARKAEADGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRTTGQREEWNISSGQARLTSQPGATLPNGHSSLSLRSHPHRGEKKGDGELSCINGDMEVRKSCRSRKNRFESVNQSLLFDQLVNSTAEAVLQEMDNINIRRNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKSLRRNSYGIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSDTTSSDEERFERRKSKSMARARNRCLPMNLRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLNAQDFYHAMQNIVPASQRAVMSSGHALSPIIKPLLERSFNNILAVLQKVFPHAEISQSDKKEDIETLILDDSEDENALSIFETSCHSGSPKKQSSAAAVHKPYLHFTMSPYHQPTSYRPRLLLSGERGSGQTSHLAPALLHTLEKFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPHIGDWWEAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYIQRPIEEDRRKFFQELILNQASMAPPRRKHTGLCAMEVLPLALPSPPRQLSESEKIRMEDQEENTLRELRLFLRDVTKRLATDKRFNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKHNYLTAKDFLKDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKEARIKRGLSVTAEQINPHGTGARKTETRVEEAFRHKQRNPMDVWHSSANKCAFRVRRKSRRRSQWGKGIIKKRKVNNLKKDEDDTKFTDYENHMEDRKLLENGEFEVSTDCHEENGEETGDLSMTNDESSCDIMDMDQGQRLNNGASTKENFASTEEESSNESLLINSSSSLNPEQTSRKEPFLKEGCLNGEASTDSFEGIPVLECQNGKAEVVSCCGSGDKCSSEQKTLLEDQSKEKPETSNENHGDDPEKLEALECSTNEKLEPGPDVEVKDAELDKEGASKVKKYRKLILEQAKTTSLELVPEEPSEPVPPLIVDHERLKKLLDLLVDKSNNLAVDQLERLYSLLSQCIYRHRKDYDKSQLVEEMERTVHMFETFL", "length": 1458, "header": "tr|F1MEY1-1|F1MEY1_BOVIN Isoform 1 of ATPase family AAA domain containing 2B OS=Bos taurus OX=9913 GN=ATAD2B PE=3 SV=3 CANONICAL=F1MEY1-1" }, "locus": { "chromosome": "11", "start_pos": 75210465, "end_pos": 75091973, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022935.8", "url": "https://www.ensembl.org/id/ENSBTAT00000022935.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022935.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022935.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518785", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518785", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A096MJU1-1", "protein_name": "ATPase family, AAA domain containing 2B", "gene_name": "Atad2b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVNTRKSSLRLLGSKSPGPGPGPGAGVEPGATGGSSHFISSRTRSSKTRAASCPAAKAGGSGGALDEARKAEVDGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRSTGQREEWNIPSGQARLTSQPGATLPNGHSSLSLRSHPLRGEKKGDGDLSCINGDMEVRKSCRSRKNRFESVNQSLLFDQLVNSTAEAVLQEMDNINIRRNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKSLRRNSYGIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSDTTSSDEERFERRKSKSMARARNRCLPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQRARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYRAMQNIVPASQRAVMSSGQALSPIIRPLLERSFNNILAVLQKIFPHAEISQSDKKEDVENLILDDSEDENALSIFEMSCHSASPKKSSPAAVTKPYLHFTMSPYHQPTSYRPRLLLSGERGSGQTSHLAPALLHTLERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPHIGDWWDAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYVQRPIEEDRRKFFQELILHQASMAPPRRKHTALRAMEVLPLALPCPPRQLSESEKSRMEDQEENTLRELRLFLRDVTKRLATDKRFNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKHNYLTAKDFLQDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKEARIKRGLSVTAEQVTPHGAGARKSETRVEEAFRHKQRNPMDAWHNSANKCAFRVRRKSRRRSQWGKGIIKKRKVNNLKKDEEDTKFTDYDHTEDRKLLENGEFEVSTDCHEENGEETGDLSMTNDESSCDIMDLDQSQRLNSGAGTKENFASTEEESSNESLLVHSSSSLNPEQTSKKEPFLKGTCLNGEASTDSFEGIPILECQNGRVLEAAPLPGAGEKSSSEQKTALEEQLKDKPETANERHGDDPEKLEVLGYSSNEIDPGPDGDGKDAELDKEGACKVKKYRKLILEQAKTTNLELVPEEPSEPVPPLVVDHERLQKLLDLLVDKSNNLTVDQLERLYSLLSQCVYRHRKDYDKSQLVEEMERTVHMFETFL", "length": 1453 }, "evidence": [ { "id": "F1MEY1", "url": "https://omabrowser.org/oma/group/F1MEY1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0AB13A7R6-1", "protein_name": "ATPase family AAA domain-containing protein 2", "gene_name": "atad2b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVNTRKSSEHKPSSPFISGRTRSSQRNNPNLDEHNSRVRKRETPAAYSLRQPKEPSSDANSSSPRLSPPPKRTRRQTPPSSTDTSPSPQSKGQRGSWTMSKHCTRLSTGALQNGHTIGRMSLRGDSTSGGDHARMNGHVELKRSRRVRKSQFEHLNQSLLFDQLVNSTAEAVLQEMDNISSIRQSREVERLRMWTDTELENMDMYSRVKRRKSLRRNTYGMQSHHKVMSKSKDPEEEEGTEESNEEGEEDEDVEADDDDEDDEGDEAEEAGEENDRPYNLRQRKTVQRYEAPPIEPVNRKQSKGSLFDTHRSPARRSHIRIKKHAIHSSESTSSSDEERFERRKSKSMSRARNRCLPMNLRAEDLASGVLRDRVKVGASLADVDPMNLDTSVKFDSVGGLTHHIQSLKEMVVFPLLYPQVFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDRKVSFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDKKARKHILEIHTRDWSPKLAEPFIDELAERCVGYCGADIKALCTEAALAALRRRYPQIYGSSQRYQLDVASIVLGPQDFGRALRSIVPAGQRALAPPGQALSCVLKPLLEPTLNQTLACLTRVFPHAELLHREHTHDSDNHLLVEDSYSEDEECLGASSIYETQSGSPKKAASCTTHKPFLHFTTSAYQQPTSYRPRLLLTGPQGAGQSTHLAPALLHHLEKFTVHRLDLPTLYSVSAKTPEESCAQVFREARRCVPSIIYMPHISAWWEAISETVKSSFLMLLQDVPSFTPLLILATAESVYQQLPDELKCIFSRSYGEVFCLSMPGEEARRKFFSDLILVQAAKAPPRRRKSACALEVLTLSEDPGPRQLSAEEQRRLEEQEENTLRELRLFLRDVTKRLATDKRFQIFSKPVDIEEVSDYLEVITQPMDLSAIMMKIDKHKYMVAKDFLADIDLICSNALEYNPDKDPGDKIIRHRACSLKDTAHAMIASELDPEFDRMCEEIKESRRKRAPQTAPQPPVTPSTVATRKPMGEEAGLSSSQGDGVDKHCSNNIKRKFRRRPIWGRGIIRKKKSYKKEEAEEDDEPEEEEGAEDSTVMAQGDACLTLDESSCDTMELHPEKQPLQANGHVLSTEEENSCEPTAARDAQGQEEAPSEEPTVAPTVPAPQECVNGNESMDSVYSEAPDKDTIKRDALEQKPTEHKEASGTECSTGENTRTAEAVASDGDHEKEGSSKGKECGKGLSEVQAEEPAVRLQEAVQLPPPPDLVVDHQRLKALLEQAVVKSEGFSVDHLERVFSALSQCIYQHRRDYDKTRLIEAMERQVEHFETFL", "length": 1402 }, "evidence": [ { "id": "F1MEY1", "url": "https://omabrowser.org/oma/group/F1MEY1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E9Q166-1", "protein_name": "ATPase family, AAA domain containing 2B", "gene_name": "Atad2b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVNTRKSSLRLLGSKSPGPGPGPGAGAGAEPGATGGSSHFISSRTRSSKTRAASCPAAKAGGSGGALDEARKAEVDGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRSTGQREEWNIPSGQTRLTSQPGATLPNGHSSLSLRSHPLRGEKKGDGDLSCINGDIEVRKSCRSRKNRFESVNQSLLFDQLVNSTAEAVLQEMDNINIRRNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKSLRRNSYGIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSDTTSSDEERFERRKSKSMARARNRCLPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQRARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALTALRRRYPQIYASSHKLQLDVTSIVLSAHDFYHAMQNIVPASQRAVMSSGQALSPIIRPLLERSFNNILAVLQKIFPHAETSQNFVAGSDLNCPSLEISSDYEETSIPEVKSSGKCFLGKKLCSKDSQGSTFVHLNFNMAFGPTSYRPRLLLSGERGSGQTSHLAPALLHTLERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPHIGDWWDAVSDTVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYIQRPIEEDRRKFFQELILHQASMAPPRRKHTALRAMEVLPLALPSPPRQLSESEKNRMEDQEENTLRELRLFLRDVTKRLATDKRFNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKHNYLTAKDFLQDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKEARIKRGLSVTAEQITPHGAGARKTETRVEEAFRHKQRNPMDAWHNSANKCAFRVRRKSRRRSQWGKGIIKKRKVNNLKKDEEDTKFTDYDHTEDRKLLENGEFEVSTDCHEENGEETGDLSMTNDESSCDIMDMDQGQRLNSGAGTKENFASTEEESSNESLLVHSSSSLNPEQTSKKEPFLKGTCLNGEASTDSSEGIPVLECQNGRVLEVVPLPDGGEKSSSEQKIALEEQLKDKPETWNENRGDAAEKLEVLECSSSEKPEPGPDAEGKETELDREGASKVKKYRKLLLEQAKPTNLELVPEEPSEPAPPLVVDHERLQKLLDLLVDKSNNLTVDQLERLYSLLSQSIYRHRKDYDKSQLVEEMERTVHMFETFL", "length": 1460 }, "evidence": [ { "id": "F1MEY1", "url": "https://omabrowser.org/oma/group/F1MEY1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9ULI0-1", "protein_name": "ATPase family AAA domain-containing protein 2B", "gene_name": "ATAD2B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVNTRKSSLRLLGSKSPGPGPGPGAGAEPGATGGSSHFISSRTRSSKTRAASCPAAKAGGSGGAGVTLDEARKVEVDGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRSTGQREEWNLSTGQARLTSQPGATLPNGHSGLSLRSHPLRGEKKGDGDLSCINGDMEVRKSCRSRKNRFESVNQSLLFDQLVNSTAEAVLQEMDNINIRRNRRSGEVERLRMWTDTEFENMDMYSRVKRRRKSLRRNSYGIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRYQAPPIVPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSDTTSSDEERFERRKSKSMARARNRCLPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYHAMQNIVPASQRAVMSSGHALSPIIRPLLERSFNNILAVLQKVFPHAEISQSDKKEDIETLILEDSEDENALSIFETNCHSGSPKKQSSSAAIHKPYLHFTMSPYHQPTSYRPRLLLSGERGSGQTSHLAPALLHTLERFSVHRLDLPALYSVSAKTPEESCAQIFREARRTVPSIVYMPHIGDWWEAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYIQRPIEEDRRKFFQELILNQASMAPPRRKHAALCAMEVLPLALPSPPRQLSESEKSRMEDQEENTLRELRLFLRDVTKRLATDKRFNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKHNYLTAKDFLKDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKEARIKRGLSVTSEQINPHSTGARKTETRVEEAFRHKQRNPMDVWHNSANKCAFRVRRKSRRRSQWGKGIIKKRKVNNLKKDEEDTKFADYENHTEDRKLLENGEFEVSTDCHEENGEETGDLSMTNDESSCDIMDLDQGQRLNNGAGTKENFASTEEESSNESLLVNSSSSLNPEQTSRKETFLKGNCLNGEASTDSFEGIPVLECQNGKLEVVSFCDSGDKCSSEQKILLEDQSKEKPETSTENHGDDLEKLEALECSNNEKLEPGSDVEVKDAELDKEGASKVKKYRKLILEQAKTTSLELVPEEPSEPVPPLIVDRERLKKLLDLLVDKSNNLAVDQLERLYSLLSQCIYRHRKDYDKSQLVEEMERTVHMFETFL", "length": 1458 }, "evidence": [ { "id": "F1MEY1", "url": "https://omabrowser.org/oma/group/F1MEY1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MEY1", "url": "https://www.uniprot.org/uniprotkb/F1MEY1" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "F1MEY1", "url": "https://www.uniprot.org/uniprotkb/F1MEY1" } ], "pmid": "" }, { "name": "histone reader activity", "id": "GO:0140566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140566", "evidence": [ { "database": "UniProtKB", "id": "F1MEY1", "url": "https://www.uniprot.org/uniprotkb/F1MEY1" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "F1MEY1", "url": "https://www.uniprot.org/uniprotkb/F1MEY1" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "F1MEY1", "url": "https://www.uniprot.org/uniprotkb/F1MEY1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MEY1", "url": "https://www.uniprot.org/uniprotkb/F1MEY1" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MEY1", "url": "https://www.uniprot.org/uniprotkb/F1MEY1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "transcription initiation-coupled chromatin remodeling", "id": "GO:0045815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045815", "evidence": [ { "database": "UniProtKB", "id": "F1MEY1", "url": "https://www.uniprot.org/uniprotkb/F1MEY1" } ], "pmid": "" }, { "name": "nucleosome assembly", "id": "GO:0006334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006334", "evidence": [ { "database": "UniProtKB", "id": "F1MEY1", "url": "https://www.uniprot.org/uniprotkb/F1MEY1" } ], "pmid": "" }, { "name": "nucleosome disassembly", "id": "GO:0006337", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006337", "evidence": [ { "database": "UniProtKB", "id": "F1MEY1", "url": "https://www.uniprot.org/uniprotkb/F1MEY1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1240, "end_pos": 1242, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1246, "end_pos": 1248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MEY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEY1" }, { "id": "PS50014", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50014" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Bromo", "eco_id": "ECO_0000259", "start_pos": 975, "end_pos": 1038, "start_aa": "Ala", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 116, "end_pos": 118 }, { "start_pos": 1240, "end_pos": 1242 }, { "start_pos": 1246, "end_pos": 1248 }, { "start_pos": 180, "end_pos": 182 }, { "start_pos": 190, "end_pos": 192 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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Classification" ] }, { "id": "PTHR13388", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13388", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13388:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13388:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15705", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15705", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15706", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15706", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16070", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16070", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23039", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23039", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23481", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23481", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23486", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23486", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23487", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23487", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005226915", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226915", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SLI7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLI7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THX3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEA1", "url": "https://www.uniprot.org/uniprotkb/F1MEA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEA1-1", "url": "https://www.uniprot.org/uniprotkb/F1MEA1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"length": 1031, "header": "tr|F1MEA1-1|F1MEA1_BOVIN Isoform 1 of Transmembrane protein 132A OS=Bos taurus OX=9913 GN=TMEM132A PE=3 SV=3 CANONICAL=F1MEA1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SLI7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLI7/entry", "sequence": { "sequence": 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"tr|A0AAA9SLI7-1|F1MEA1_BOVIN Computationally mapped isoform of Transmembrane protein 132A OS=Bos taurus OX=9913 GN=TMEM132A PE=3 SV=1 CANONICAL=F1MEA1-1" }, "locus": { "chromosome": "29", "start_pos": 37275456, "end_pos": 37261964, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121437.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121437.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087233.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087233.1" } ] } }, { "isoform_ac": "A0AAA9THX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THX3/entry", "sequence": { "sequence": "MCAWMAGRTAAAPRGPRGPWLCLLVAFALDIVRVDCDQDPLDPVYLPAALGLLDAPEHFRVQQVGRYPPANSSLGSRSETFLLLQPWPRAQPLLRASYPPFATQQVVPPRVTEPHQRPVPWDVRAVSVEAAVTPAEPHARVLFHLRGQDWPPGPGSLPCARLHATHPAGTAHRACRFQPSLGACVVELEFPSHWFSQGSATRAELAYTLEPAAEGPGGCGPGGEEDPGEQALPVGSVELRPADPPQHQEVPLDEAVTLRVPDVPVRPGQLFSATLLLRHNFTAGVLTLRIKVKKGLHVMAARLAQPTLWTTKLERFKGSKHHTTLITCHRVGPVEPNSSSPLELSEFLWVDFLVENGTSGGVAVTRPVTWQLEYPGQAPEAEKDKMVWEILVSEQDIRALVPLAKVSEACDAVFVSGKESRGALGVRVDFWWRRLRASLRMTVWAPLLPLRIEVTDTTLEQVRGWRVPGPAEGAREPEAAGVEEAERRARGCRLQYQRAGVRFLVPFAAHPLDGGRRLTHLLGPDWLLDVSHLVAPHARVQDPRVASLEGGRVLVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELRVQPVMGISLALSRGTAHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTLAPAELYDHHDLGLSVSAEEPGAVLPAEEQGAQLRVVVSGAGTEGLPLHVALHPPEPCRRGRHRVPLASGTAWLGLPPAPTSAPALPSSPARSSSPAPGASVGGGRWAAGSMGGSGDVRGKFEQTEEEARKEEAEAREEEEEEGEEEMVPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQRKEPPDGATDPASPQPHNWVWLGTDQEELSRQLDRQSPGPPKGEGGCPCESGGGGEALTLAQAQAQAPPTGATTSSSGTLARKEAGGRRKRVEFVTFAPAPPAQLPEEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEELRSYMERIRGSS", "length": 983, "header": "tr|A0AAA9THX3-1|F1MEA1_BOVIN Computationally mapped isoform of Transmembrane protein 132A OS=Bos taurus OX=9913 GN=TMEM132A PE=3 SV=1 CANONICAL=F1MEA1-1" }, "locus": { "chromosome": "29", "start_pos": 37275456, "end_pos": 37261964, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089958.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089958.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097867.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097867.1" } ] } }, { "isoform_ac": "F1MEA1-1", "url": "https://www.uniprot.org/uniprotkb/F1MEA1/entry", "sequence": { "sequence": "MCAWMAGRTAAAPRGPRGPWLCLLVAFALDIVRVDCDQDPLDPVYLPAALGLLDAPEHFRVQQVGRYPPANSSLGSRSETFLLLQPWPRAQPLLRASYPPFATQQVVPPRVTEPHQRPVPWDVRAVSVEAAVTPAEPHARVLFHLRGQDWPPGPGSLPCARLHATHPAGTAHRACRFQPSLGACVVELEFPSHWFSQGSATRAELAYTLEPAAEGPGGCGPGGEEDPGEQALPVGSVELRPADPPQHQEVPLDEAVTLRVPDVPVRPGQLFSATLLLRHNFTAGVLTLRIKVKKGLHVMAARLAQPTLWTTKLERFKGSKHHTTLITCHRVGPVEPNSSSPLELSEFLWVDFLVENGTSGGVAVTRPVTWQLEYPGQAPEAEKDKMVWEILVSEQDIRALVPLAKAEELVNTAPLTGVPRRIPVRLVTVDSGGALVEVTEHIGCESANTQVLQVSEACDAVFVSGKESRGALGVRVDFWWRRLRASLRMTVWAPLLPLRIEVTDTTLEQVRGWRVPGPAEGAREPEAAGVEEAERRARGCRLQYQRAGVRFLVPFAAHPLDGGRRLTHLLGPDWLLDVSHLVAPHARVQDPRVASLEGGRVLVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELRVQPVMGISLALSRGTAHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTLAPAELYDHHDLGLSVSAEEPGAVLPAEEQGAQLRVVVSGAGTEGLPLHVALHPPEPCRRGRHRVPLASGTAWLGLPPAPTSAPALPSSPARSSSPAPGASVGGGRWAAGSMGGSGDVRGKFEQTEEEARKEEAEAREEEEEEGEEEMVPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQRKEPPDGATDPASPQPHNWVWLGTDQEELSRQLDRQSPGPPKGEGGCPCESGGGGEALTLAQAQAQAPPTGATTSSSGTLARKEAGGRRKRVEFVTFAPAPPAQLPEEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEELRSYMERIRGSS", "length": 1031, "header": "tr|F1MEA1-1|F1MEA1_BOVIN Isoform 1 of Transmembrane protein 132A OS=Bos taurus OX=9913 GN=TMEM132A PE=3 SV=3 CANONICAL=F1MEA1-1" }, "locus": { "chromosome": "29", "start_pos": 37275456, "end_pos": 37261964, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024433.8", "url": "https://www.ensembl.org/id/ENSBTAT00000024433.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024433.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024433.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 133, "start_aa": "Thr", "end_pos": 133, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr133", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 365, "start_aa": "Thr", "end_pos": 365, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr365", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 772, "start_aa": "Thr", "end_pos": 772, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr772", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": 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ribonucleoprotein", "type": "synonym", "evidence": [ { "id": "F1MIZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIZ7/entry#names_and_taxonomy" } ] }, { "name": "TROVE domain family member 2", "type": "synonym", "evidence": [ { "id": "F1MIZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIZ7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MIZ7", "url": "https://www.uniprot.org/uniprotkb/F1MIZ7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RO60", "url": "https://www.uniprot.org/uniprotkb/F1MIZ7", "locus": { "chromosome": "16", "start_pos": 12164240, "end_pos": 12191080, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013812", "url": 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"https://www.ebi.ac.uk/interpro/entry/IPR040322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056800", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WWYEWLK", "url": "https://omabrowser.org/oma/group/WWYEWLK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR14202", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14202", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14202:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14202:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05731", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05731", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25045", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25045", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SMK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIZ7", "url": "https://www.uniprot.org/uniprotkb/F1MIZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIZ7-1", "url": "https://www.uniprot.org/uniprotkb/F1MIZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAPGVETGDFQVVKWRPGRRVRASEPSPGASNPGDTFLSLRGGSQIATETRLAGTEALPFPRLSPTSGFGSRLLSDARRPEPQRSARDQLRPPPVTRHRPRTAPLALTKSFNELGEDPGVALHEAPLPGIARHGPGRAPPRSTSGSGRPGPSLLPPPATELGKPAAGSSTTRHPAYFPTASAAPSPGARQSAGGRSSHPGAGETLPGPRWTRSGFGRGRGRAVWAKSEKGRGLGPLRREHPGPSPVWGRGGARPGGGARAREPNPEAPAAAPEQSSRVRPPCVVVLRWRRVAAQHFSRWRGGFGGLAAGHRLPKDRKMEESVNQMQPLNEKQIANSEGGYVWQVTDMNRLHRFLCFGSEGGTYCIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTAKQEPTLFALAICSQCSDISTKQAAFKAVPEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAVADWYNEKGGMALALAVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHEMYKEKALSVEAEKLLKYLEAVEKVKRTKDELEVIHLIEEHRLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHVLIALETYKTGHGLRGKLKWRPDEEILQALDAAFYKTFKTVEPTGKRFLLAIDVSGSMDQRVLGSVLNASTVAAAMCMVVTRTEKDSSIVAFSDEMVPCPVTTDMTLQQVLLAMSQIPAGGTDCSLPMIWAQKTNTAADVFIVFTDNETFAGSVHPAIALREYRKNMDIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTGALDVIRSFTLDMI", "length": 856, "header": "tr|F1MIZ7-1|F1MIZ7_BOVIN Isoform 1 of RNA-binding protein RO60 OS=Bos taurus OX=9913 GN=RO60 PE=3 SV=3 CANONICAL=F1MIZ7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMK8/entry", "sequence": { "sequence": "MGAPGVETGDFQVVKWRPGRRVRASEPSPGASNPGDTFLSLRGGSQIATETRLAGTEALPFPRLSPTSGFGSRLLSDARRPEPQRSARDQLRPPPVTRHRPRTAPLALTKSFNELGEDPGVALHEAPLPGIARHGPGRAPPRSTSGSGRPGPSLLPPPATELGKPAAGSSTTRHPAYFPTASAAPSPGARQSAGGRSSHPGAGETLPGPRWTRSGFGRGRGRAVWAKSEKGRGLGPLRREHPGPSPVWGRGGARPGGGARAREPNPEAPAAAPEQSSRVRPPCVVVLRWRRVAAQHFSRWRGGFGGLAAGHRLPKDRKMEESVNQMQPLNEKQIANSEGGYVWQVTDMNRLHRFLCFGSEGGTYCIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTAKQEPTLFALAICSQCSDISTKQAAFKAVPEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAVADWYNEKGGMALALAVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHEMYKEKALSVEAEKLLKYLEAVEKVKRTKDELEVIHLIEEHRLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHVLIALETYKTGHGLRGKLKWRPDEEILQALDAAFYKTFKVVTRTEKDSSIVAFSDEMVPCPVTTDMTLQQVLLAMSQIPAGGTDCSLPMIWAQKTNTAADVFIVFTDNETFAGSVHPAIALREYRKNMDIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTGALDVIRSFTLDMI", "length": 817, "header": "tr|A0AAA9SMK8-1|F1MIZ7_BOVIN Computationally mapped isoform of RNA-binding protein RO60 OS=Bos taurus OX=9913 GN=RO60 PE=3 SV=1 CANONICAL=F1MIZ7-1" }, "locus": { "chromosome": "16", "start_pos": 12190959, "end_pos": 12165328, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099095.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099095.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085187.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085187.1" } ] } }, { "isoform_ac": "F1MIZ7-1", "url": "https://www.uniprot.org/uniprotkb/F1MIZ7/entry", "sequence": { "sequence": "MGAPGVETGDFQVVKWRPGRRVRASEPSPGASNPGDTFLSLRGGSQIATETRLAGTEALPFPRLSPTSGFGSRLLSDARRPEPQRSARDQLRPPPVTRHRPRTAPLALTKSFNELGEDPGVALHEAPLPGIARHGPGRAPPRSTSGSGRPGPSLLPPPATELGKPAAGSSTTRHPAYFPTASAAPSPGARQSAGGRSSHPGAGETLPGPRWTRSGFGRGRGRAVWAKSEKGRGLGPLRREHPGPSPVWGRGGARPGGGARAREPNPEAPAAAPEQSSRVRPPCVVVLRWRRVAAQHFSRWRGGFGGLAAGHRLPKDRKMEESVNQMQPLNEKQIANSEGGYVWQVTDMNRLHRFLCFGSEGGTYCIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTAKQEPTLFALAICSQCSDISTKQAAFKAVPEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAVADWYNEKGGMALALAVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHEMYKEKALSVEAEKLLKYLEAVEKVKRTKDELEVIHLIEEHRLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHVLIALETYKTGHGLRGKLKWRPDEEILQALDAAFYKTFKTVEPTGKRFLLAIDVSGSMDQRVLGSVLNASTVAAAMCMVVTRTEKDSSIVAFSDEMVPCPVTTDMTLQQVLLAMSQIPAGGTDCSLPMIWAQKTNTAADVFIVFTDNETFAGSVHPAIALREYRKNMDIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTGALDVIRSFTLDMI", "length": 856, "header": "tr|F1MIZ7-1|F1MIZ7_BOVIN Isoform 1 of RNA-binding protein RO60 OS=Bos taurus OX=9913 GN=RO60 PE=3 SV=3 CANONICAL=F1MIZ7-1" }, "locus": { "chromosome": "16", "start_pos": 12190959, "end_pos": 12165328, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018350.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018350.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018350.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018350.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287B6J4-1", "protein_name": "RNA-binding protein RO60", "gene_name": "RO60", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEESVSQMQPMHETQLANSEGGYVWQVTDMNRLHRFLCFGSEGGTYYIQEQRLGLQNAEALLRLIEDGRGCEVIQEIKSFSQEGRNAKQEPTLFALAICSQCSDTSTKQAAFKAVPEVCRIPTHLFTFIQFKKDLKESMHCGMWGRALRKAVADWYNEKGGMALALAVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHDTYKEKALSVETERLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHVLVALETYKTGHGLRGKLKWRPDEEILQALDAAFYKTFKMVEPTGKRFLLAVDVSGSMEQRVLGSILSASTVAAAMCMVVTRTESDSYIVAFSDEMVPCPLTTDMTLQQVLMAMSQIPAGETDCSLPMIWAQKTNTAADVFIVFTDNETFAGSVHPAAALREYRKKMGIPAKLIVCGMASNGFTIADPDDRGMLDMCGFDTGALDVIRNFTLDVI", "length": 538 }, "evidence": [ { "id": "F1MIZ7", "url": "https://omabrowser.org/oma/group/F1MIZ7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A3L7HK29-1", "protein_name": "RNA-binding protein RO60", "gene_name": "Ro60", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEESANQLQPLSESQVANSEGGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTAKQEPLLFALAICSQCSDIKTKQAAFKAVPEVCRIPTHLFTFIQFKKDLKQSMKCGMWGRALRKAVADWYNEKGGMAIALAVTKYKQRNGWSHKDLLRLSHLKPSSEGLAVVTKYITKGWKEVHELYREKALSVETEKLLKYLEAVEKVKRTKDELEVIHLIEEHQLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHVLIALETYRTGHGLRGKLKWTPDKEILQALDTAFYKTFKTVEPTGKRFLLAVDVSASMNQRVLGNILNASTVAAAMCMVVTRTEKESSIVAFACDMVPFPVTTDMTLQQVLTAMNKVPAGSTDCSLPMIWAQKTNTAADVFIVFTDNETYAGQVHPAVALREYRKKMNIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTSALDVIRNFTLDVI", "length": 538 }, "evidence": [ { "id": "F1MIZ7", "url": "https://omabrowser.org/oma/group/F1MIZ7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0YF85-1", "protein_name": "RNA-binding protein RO60", "gene_name": "TROVE2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MMEDEANQVQPLNEMQVPNSDSDYVWHVTDMNRLHRFLCFGSEGGTYCVKEQRLGFESAAALMRLVEEGRGCEVVQEIKTFSQEGRTAKQEPLLFALAICSQCSDAKTKQAAFKAVPEVCCVPTHLFTFIQFKKDLKEGMKCGMWGRALRKAVADWYNGKNGMAVALAVTKYKQRSGWSHKDLLRLSHLKPASEGVAIVTKYITKGWKDVQEAYKDKAVSAETEKLLKYLEAVDRVKHTKDELEVIHLIEEYGLVREHLLTNHLKSKEVWKALLKDMPISVLLRNLGKMTANSVLEPRSSEVAIVCERLRNEKLLKKGRIHPFHVWVALETYKSGHGSRGKLWWRPDEDILEALDASFYKTFETVEPTGKRFVVAVDVSASMTQKVLGSVLNANTVAAIMCMVVARTEKDSHIVAFSHELVPCPVTADMTLPQVLVKMYEIPMGTTDCSLPMIWAQKTQTAADVFIVFTDNETFAGNTRPATALREYREKMGIPAKLIVCGMTSNGFTIADPDDRGMLDICGFDAGALDVIRNFILDLI", "length": 539 }, "evidence": [ { "id": "F1MIZ7", "url": "https://omabrowser.org/oma/group/F1MIZ7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZRN5-1", "protein_name": "RNA-binding protein RO60", "gene_name": "Ro60", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEESANQLQPLSDNQVANSEGGYVWQVTDMNRLHRFLCFGSEGGTCYIKEQKLGLENAEALIRLIEDGRGSEVIQEIKSFSQEGRTAKQEPLLFALAICSQCADVSTKQAAFKAVPEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAVADWYNEKGGMAVALAVTKYKQRNGWSHKDLLRLSHLKPNSEGLAIVTKYITKGWKEVHEQYKEKPLSVETDKLLKYLEAVEKVKRTKDDLEVTHLIEEHQLVREQLLTSHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGSSEVSLVCEKLSNEKLLKKARIHPFHVLTALETYRTGHGLRGKLKWIPDKEILQALDAAFYKTFKTVEPTGKRFLLAVDVSGSMDQRVLGSVLNASTVAAAMCMVVTRTEKESSVVAFACDMVPFPVTTDMTLQQVLTAMNKVPAGTTDCSLPMIWAQKTGTAADVFIVFTDNETFAGQVHPAIALREYRKKMAIPAKLLVCGMTSNGFTIADPDDRGMLDMCGFDTAALDVIRNFTLDVI", "length": 538 }, "evidence": [ { "id": "F1MIZ7", "url": "https://omabrowser.org/oma/group/F1MIZ7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O08848-1", "protein_name": "RNA-binding protein Ro60", "gene_name": "RO60", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGSANQLQPLSETQVVNSEGGCVWQVTDMNRLRRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTAKQEPLLFALAVCSQCADINTKQAAFKAVPEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAVADWYNEKGGMAVALVVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHEEYKEKALSVEAEKLLKYLEAVEKVKRTKDDLEVIHLIEEHQLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLICEKLSNEKLLKKARIHPFHVLIALETYRAGHGLRGKLKWIPDKDILQALDAAFYTTFKTVEPTGKRFLLAVDVSASMNQRALGSVLNASTVAAAMCMVVTRTEKESSVVAFACDMVPFPVTTDMTLQQVLTAMNKVPAGNTDCSLPMIWAQKTDTAADVFVVFTDNETFAGQVHPAVALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTAALDVIRNFTLDVI", "length": 538 }, "evidence": [ { "id": "F1MIZ7", "url": "https://omabrowser.org/oma/group/F1MIZ7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P10155-1", "protein_name": "RNA-binding protein RO60", "gene_name": "RO60", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTTKQEPMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAIADWYNEKGGMALALAVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKLLKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKTFKTVEPTGKRFLLAVDVSASMNQRVLGSILNASTVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLPMIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTGALDVIRNFTLDMI", "length": 538 }, "evidence": [ { "id": "F1MIZ7", "url": "https://omabrowser.org/oma/group/F1MIZ7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1MIZ7", "url": "https://www.uniprot.org/uniprotkb/F1MIZ7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MIZ7", "url": "https://www.uniprot.org/uniprotkb/F1MIZ7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MIZ7", "url": "https://www.uniprot.org/uniprotkb/F1MIZ7" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "F1MIZ7", "url": "https://www.uniprot.org/uniprotkb/F1MIZ7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell projection organization", "id": "GO:0030030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "database": "UniProtKB", "id": "F1MIZ7", "url": "https://www.uniprot.org/uniprotkb/F1MIZ7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 709, "end_pos": 711, "annotation": "n_glycosylation_sequon" }, { "start_pos": 788, "end_pos": 790, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MIZ7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 856, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MIZ7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MIZ7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MIZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIZ7" }, { "id": "PS50988", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50988" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TROVE", "eco_id": "ECO_0000259", "start_pos": 334, "end_pos": 687, "start_aa": "Ile", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 709, "end_pos": 711 }, { "start_pos": 788, "end_pos": 790 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MCF4-1", "uniprot_ac": "F1MCF4", "uniprot_id": "F1MCF4_BOVIN", "mass": { "chemical_mass": 43226.0, "monoisotopic_mass": 43226.0 }, "refseq": { "ac": "XP_024857654", "name": "transmembrane protein 64 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857654" }, "gene_names": [ { "name": "TMEM64", "type": "recommended", "evidence": [ { "id": "F1MCF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCF4" } ] }, { "name": "TMEM64", "type": "synonym", "evidence": [ { "id": "XP_024857654", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857654" } ] } ], "protein_names": [ { "name": "Transmembrane protein 64", "type": "synonym", "evidence": [ { "id": "F1MCF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCF4/entry#names_and_taxonomy" } ] }, { "name": "transmembrane protein 64 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024857654", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857654" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MCF4", "url": "https://www.uniprot.org/uniprotkb/F1MCF4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMEM64", "url": "https://www.uniprot.org/uniprotkb/F1MCF4", "locus": { "chromosome": "14", "start_pos": 73570954, "end_pos": 73535404, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011268", "url": "https://www.ensembl.org/id/ENSBTAG00000011268" } ] } } ], "crossref": [ { "id": "F1MCF4", "url": "https://alphafold.ebi.ac.uk/entry/F1MCF4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011268", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011268", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "536822", "url": "https://www.ncbi.nlm.nih.gov/gene/536822", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR032816", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032816", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536822", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536822", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MCF4", "url": "https://www.orthodb.org/?gene=F1MCF4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46593", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46593", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46593:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46593:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09335", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09335", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024857654", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857654", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SNM7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCF4", "url": "https://www.uniprot.org/uniprotkb/F1MCF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCF4-1", "url": "https://www.uniprot.org/uniprotkb/F1MCF4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWSAGGSLLQSLPRLLQYAAALPGHTEPPPPAGWALPRAAGGDGPAERLPPRGGGASAAAVAAAAPGALLGACLERHAPSDASELPGPGGALAGGPGGGGVVVDVAEVRSWRCCCLGSTCWCRSLVLVCVLAAVCFASLALVRRYLQHLLLWAESLDSLLGVLLFVVGFIVVSFPCGWGYIVLNVAAGYLYGFVLGMGLMVVGVLIGTFIAHVVCKRLLTAWVAARIQSSEKLSAVIRVVEGGSGLKVVALARLTPIPFGLQNAVFSITDLSLPNYLVASSAGLLPTQLLNSYLGTTLRTMEDVIAEQSASGYFVFCLQVSLSAFGIRVMVASQNEFGSFPSSAVVWNSFRRIIISIGLMFYVVHRAQVELNAAIVACEMELKTSLVKGNQPNISGSSFYKRTLTFSGDGINIV", "length": 414, "header": "tr|F1MCF4-1|F1MCF4_BOVIN Isoform 1 of Transmembrane protein 64 OS=Bos taurus OX=9913 GN=TMEM64 PE=4 SV=4 CANONICAL=F1MCF4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SNM7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNM7/entry", "sequence": { "sequence": "MWSAGGSLLQSLPRLLQYAAALPGHTEPPPPAGWALPRAAGGDGPAERLPPRGGGASAAAVAAAAPGALLGACLERHAPSDASELPGPGGALAGGPGGGGVVVDVAEVRSWRCCCLGSTCWCRSLVLVCVLAAVCFASLALVRRYLQHLLLWAESLDSLLGVLLFVVGFIVVSFPCGWGYIVLNVAAGYLYGFVLGMGLMVVGVLIGTFIAHVVCKRLLTAWVAARIQSSEKLSAVIRVVEGGSGLKVVALARLTPIPFGLQNAVFSITDLSLPNYLVASSAGLLPTQLLNSYLGTTLRTMEDVIAEQSASGYFVFCLQIIISIGLMFYVVHRAQVELNAAIVACEMELKTSLVKGNQPNISGSSFYKRTLTFSGDGINIV", "length": 381, "header": "tr|A0AAA9SNM7-1|F1MCF4_BOVIN Computationally mapped isoform of Transmembrane protein 64 OS=Bos taurus OX=9913 GN=TMEM64 PE=4 SV=1 CANONICAL=F1MCF4-1" }, "locus": { "chromosome": "14", "start_pos": 73569950, "end_pos": 73535603, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094317.2", "url": "https://www.ensembl.org/id/ENSBTAT00000094317.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086948.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086948.1" } ] } }, { "isoform_ac": "F1MCF4-1", "url": "https://www.uniprot.org/uniprotkb/F1MCF4/entry", "sequence": { "sequence": "MWSAGGSLLQSLPRLLQYAAALPGHTEPPPPAGWALPRAAGGDGPAERLPPRGGGASAAAVAAAAPGALLGACLERHAPSDASELPGPGGALAGGPGGGGVVVDVAEVRSWRCCCLGSTCWCRSLVLVCVLAAVCFASLALVRRYLQHLLLWAESLDSLLGVLLFVVGFIVVSFPCGWGYIVLNVAAGYLYGFVLGMGLMVVGVLIGTFIAHVVCKRLLTAWVAARIQSSEKLSAVIRVVEGGSGLKVVALARLTPIPFGLQNAVFSITDLSLPNYLVASSAGLLPTQLLNSYLGTTLRTMEDVIAEQSASGYFVFCLQVSLSAFGIRVMVASQNEFGSFPSSAVVWNSFRRIIISIGLMFYVVHRAQVELNAAIVACEMELKTSLVKGNQPNISGSSFYKRTLTFSGDGINIV", "length": 414, "header": "tr|F1MCF4-1|F1MCF4_BOVIN Isoform 1 of Transmembrane protein 64 OS=Bos taurus OX=9913 GN=TMEM64 PE=4 SV=4 CANONICAL=F1MCF4-1" }, "locus": { "chromosome": "14", "start_pos": 73569950, "end_pos": 73535603, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045778.5", "url": "https://www.ensembl.org/id/ENSBTAT00000045778.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043140.5", "url": "https://www.ensembl.org/id/ENSBTAP00000043140.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:536822", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536822", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1MCF4", "url": "https://www.uniprot.org/uniprotkb/F1MCF4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of fat cell differentiation", "id": "GO:0045600", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045600", "evidence": [ { "database": "UniProtKB", "id": "F1MCF4", "url": "https://www.uniprot.org/uniprotkb/F1MCF4" } ], "pmid": "" }, { "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "evidence": [ { "database": "UniProtKB", "id": "F1MCF4", "url": "https://www.uniprot.org/uniprotkb/F1MCF4" } ], "pmid": "" }, { "name": "negative regulation of osteoblast differentiation", "id": "GO:0045668", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045668", "evidence": [ { "database": "UniProtKB", "id": "F1MCF4", "url": "https://www.uniprot.org/uniprotkb/F1MCF4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MCF4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 414, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MCF4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MCF4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MCF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCF4" }, { "id": "PF09335", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09335" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VTT", "eco_id": "ECO_0000259", "start_pos": 182, "end_pos": 296, "start_aa": "Val", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 393, "end_pos": 395 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { 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"uniprot_ac": "F1MFR7", "uniprot_id": "F1MFR7_BOVIN", "mass": { "chemical_mass": 55287.0, "monoisotopic_mass": 55287.0 }, "refseq": { "ac": "NP_001421749", "name": "sodium/hydrogen exchanger 9B1 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421749" }, "gene_names": [ { "name": "SLC9B1", "type": "recommended", "evidence": [ { "id": "F1MFR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR7" } ] }, { "name": "NHEDC1", "type": "synonym", "evidence": [ { "id": "NP_001421749", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421749" } ] }, { "name": "SLC9B1", "type": "synonym", "evidence": [ { "id": "NP_001421749", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421749" } ] } ], "protein_names": [ { "name": "Na+/H+ exchanger domain containing 1", "type": "synonym", "evidence": [ { "id": "NP_001421749", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421749" } ] }, { "name": "Solute carrier family 9 member B1", "type": "synonym", "evidence": [ { "id": "F1MFR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR7/entry#names_and_taxonomy" } ] }, { "name": "sodium/hydrogen exchanger 9B1 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001421749", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421749" } ] }, { "name": "solute carrier family 9, subfamily B (cation proton antiporter 2), member 1", "type": "synonym", "evidence": [ { "id": "NP_001421749", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421749" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFR7", "url": "https://www.uniprot.org/uniprotkb/F1MFR7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC9B1", "url": "https://www.uniprot.org/uniprotkb/F1MFR7", "locus": { "chromosome": "6", "start_pos": 21965495, "end_pos": 21861360, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009673", "url": "https://www.ensembl.org/id/ENSBTAG00000009673" } ] } } ], "crossref": [ { "id": "F1MFR7", "url": "https://alphafold.ebi.ac.uk/entry/F1MFR7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009673", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009673", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509608", "url": "https://www.ncbi.nlm.nih.gov/gene/509608", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VPMKRAF", "url": "https://omabrowser.org/oma/group/VPMKRAF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR31102", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31102", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31102:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31102:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00999", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00999", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2672351", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001421749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421749", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SRQ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TJP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFR7", "url": "https://www.uniprot.org/uniprotkb/F1MFR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFR7-1", "url": "https://www.uniprot.org/uniprotkb/F1MFR7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYTEEPQNEHLEDENVQSSTTPEILKATSANEHEETKETILPETEETKPQMEKKGSCPPQGTLNKAITNGAILFMIWCVVWAFSGPEVLPNGSLFGLLVIFYCALIGGKLLEVIRLPSVPEIPPLLGMLLAGFAVRNVPFLSDITYISNELSSTLRNTALTIILVRAGLGLDPQALKNLKRVCLRLSMGPCLMEACSTAVISHFLMNFPWQWGFLLGFVVGAVSPAVVVPSMLHLQEKGYGIEKGIPTLLIAASSLDDILAITGFNACFSIVFSSGNISSNVLSSLRDVILGVLLGIVLGMFARHFPGSDQGKLEVKRAFLILSMCISAVLGSHRFGMNTAGGLCALVLSFTAGTGWSKEKVRVQKIIGTAWDIFQPLLFGLVGAEVSVLSLKSNAIGLSVGTMSLALLIRISFTFVLMSCAGFNFKEKIFIALSWMPKATVQAVLGPLALEKARMSAPHLESYSEDVMTVAFLAILITAPNGALIIGILGPKVLTRYDKSKVKMELSGLELH", "length": 513, "header": "tr|F1MFR7-1|F1MFR7_BOVIN Isoform 1 of Solute carrier family 9 member B1 OS=Bos taurus OX=9913 GN=SLC9B1 PE=3 SV=2 CANONICAL=F1MFR7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRQ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRQ1/entry", "sequence": { "sequence": "MYTEEPQNEHLEDENVQSSTTPEILKATSANEHEETKETILPETEETKPQMEKKGSCPPQGTLNKAITNGAILFMIWCVVWAFSGPEVLPNGSLFGLLVIFYCALIGGKLLEVIRLPSVPEIPPLLGMLLAGFAVRNVPFLSDITYISNELSSTLRNTALTIILVRAGLGLDPQALKNLKRVCLRLSMGPCLMEACSTAVISHFLMNFPWQWGFLLGFVVGAVSPAVVVPSMLHLQEKGYGIEKGIPTLLIAASSLDDILAITGFNACFSIVFSSGNISSNVLSSLRDVILGVLLGIVLGMFARHFPGSDQGKLEVKRAFLILSMCISAVLGSHRFGMNTAGGLCALVLSFTAGTGWSKEKVRVQKIIGTAWDIFQPLLFGLVGAEVSVLSLKSNAIGLSVGTMSLALLIRISFTFVLMSCAGFNFKEKIFIALSWMPKATVQNQLPAAAKSLQSCPTLCDPMDCSLPGFSVHGVLQARTLEWVAISFSNAGKWKVKVKSLSRV", "length": 504, "header": "tr|A0AAA9SRQ1-1|F1MFR7_BOVIN Computationally mapped isoform of Solute carrier family 9 member B1 OS=Bos taurus OX=9913 GN=SLC9B1 PE=3 SV=1 CANONICAL=F1MFR7-1" }, "locus": { "chromosome": "6", "start_pos": 21938049, "end_pos": 21892209, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126817.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126817.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086642.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086642.1" } ] } }, { "isoform_ac": "A0AAA9TJP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJP3/entry", "sequence": { "sequence": "MYTEEPQNEHLEDENVQSSTTPEILKATSANEHEETKETILPETEETKPQMEKKGSCPPQGTLNKAITNGAILFMIWCVVWAFSGPEVLPNGSLFGLLVIFYCALIGGKLLEVIRLPSVPEIPPLLGMLLAGFAVRNVPFLSDITYISNELSSTLRNTALTIILVRAGLGLDPQALKNLKRVCLRLSMGPCLMEACSTAVISHFLMNFPWQWGFLLGFVVGAVSPAVVVPSMLHLQEKGYGIEKGIPTLLIAASSLDDILAITGFNACFSIVFSSGNISSNVLSSLRDVILGVLLGIVLGMFARHFPGSDQGKLEVKRAFLILSMCISAVLGSHRFGMNTAGGLCALVLSFTAGTGWSKEKVRVQKIIGTAWDIFQPLLFGLVGAEVSVLSLKSNAIGLSVGTMSLALLIRISFTFVLMSCAGFNFKEKIFIALSWMPKATVQINQAILLLLFLREEWTNCKVAKCEYAKERQQ", "length": 474, "header": "tr|A0AAA9TJP3-1|F1MFR7_BOVIN Computationally mapped isoform of Solute carrier family 9 member B1 OS=Bos taurus OX=9913 GN=SLC9B1 PE=3 SV=1 CANONICAL=F1MFR7-1" }, "locus": { "chromosome": "6", "start_pos": 21965495, "end_pos": 21892209, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117041.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117041.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096472.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096472.1" } ] } }, { "isoform_ac": "F1MFR7-1", "url": "https://www.uniprot.org/uniprotkb/F1MFR7/entry", "sequence": { "sequence": "MYTEEPQNEHLEDENVQSSTTPEILKATSANEHEETKETILPETEETKPQMEKKGSCPPQGTLNKAITNGAILFMIWCVVWAFSGPEVLPNGSLFGLLVIFYCALIGGKLLEVIRLPSVPEIPPLLGMLLAGFAVRNVPFLSDITYISNELSSTLRNTALTIILVRAGLGLDPQALKNLKRVCLRLSMGPCLMEACSTAVISHFLMNFPWQWGFLLGFVVGAVSPAVVVPSMLHLQEKGYGIEKGIPTLLIAASSLDDILAITGFNACFSIVFSSGNISSNVLSSLRDVILGVLLGIVLGMFARHFPGSDQGKLEVKRAFLILSMCISAVLGSHRFGMNTAGGLCALVLSFTAGTGWSKEKVRVQKIIGTAWDIFQPLLFGLVGAEVSVLSLKSNAIGLSVGTMSLALLIRISFTFVLMSCAGFNFKEKIFIALSWMPKATVQAVLGPLALEKARMSAPHLESYSEDVMTVAFLAILITAPNGALIIGILGPKVLTRYDKSKVKMELSGLELH", "length": 513, "header": "tr|F1MFR7-1|F1MFR7_BOVIN Isoform 1 of Solute carrier family 9 member B1 OS=Bos taurus OX=9913 GN=SLC9B1 PE=3 SV=2 CANONICAL=F1MFR7-1" }, "locus": { "chromosome": "6", "start_pos": 21928364, "end_pos": 21892209, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027774.8", "url": "https://www.ensembl.org/id/ENSBTAT00000027774.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027774.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027774.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2672351", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "resource": "Reactome", "description": "Stimuli-sensing channels" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8C0X2-1", "protein_name": "Sodium/hydrogen exchanger 9B1", "gene_name": "Slc9b1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEHDVESNKKDDGFQSSVTVEMSKDPDSFHEETVEPKPELKEPEPKEPEPKEPERKEPERKEPERKEPERKEPERKVPGRRETQTKETQTTEIERKETKKKRGTNSYCPPQGTINKTITDGAALIALWTLLWALIGQEVLPGGNLFGLVVIFYSAFLGGKILEFIKIPVVPPLPPLIGMLLAGFTIRNVPIIYEFVHIPTTWSSALRNTALTIILVRAGLGLDPQALKHLKGVCLRLSFGPCFLEACSAALFSHFIMNFPWQWGFLLGFVLGAVSPAVVVPNMLMLQENGYGVEKGIPTLLVAASSMDDIVAITGFNTFLSIVFSSGSVISNILSSLRDVLIGVLVGIVMGVFVQYFPSGDQERLTQRRAFLVLSMCISAVLGCQHIGLHGSGGLVTLVLSFMAAKRWAEEKVGIQKIVANTWNVFQPLLFGLVGTEVSVESLESKTIGMCLATLGLALSVRILSTFVLMSFANFRFKEKVFIALSWIPKATVQAVLGPLALETARVMAPHLEGYAKAVMTVAFLAILITAPNGALLIGILGPKILEQSEVTFPLKVELSNFHH", "length": 565 }, "evidence": [ { "id": "F1MFR7", "url": "https://omabrowser.org/oma/group/F1MFR7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MFR7", "url": "https://www.uniprot.org/uniprotkb/F1MFR7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MFR7", "url": "https://www.uniprot.org/uniprotkb/F1MFR7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MFR7", "url": "https://www.uniprot.org/uniprotkb/F1MFR7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "antiporter activity", "id": "GO:0015297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015297", "evidence": [ { "database": "UniProtKB", "id": "F1MFR7", "url": "https://www.uniprot.org/uniprotkb/F1MFR7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proton transmembrane transport", "id": "GO:1902600", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902600", "evidence": [ { "database": "UniProtKB", "id": "F1MFR7", "url": "https://www.uniprot.org/uniprotkb/F1MFR7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MFR7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 513, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MFR7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MFR7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR7" }, { "id": "PF00999", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00999" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cation/H+ exchanger transmembrane", "eco_id": "ECO_0000259", "start_pos": 113, "end_pos": 481, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 277, "end_pos": 279 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"monoisotopic_mass": 138568.0 }, "refseq": {}, "gene_names": [ { "name": "ABCB5", "type": "recommended", "evidence": [ { "id": "F1MC51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC51" } ] } ], "protein_names": [ { "name": "ATP-binding cassette sub-family B member 5", "type": "recommended", "evidence": [ { "id": "F1MC51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC51/entry#names_and_taxonomy" } ] }, { "name": "7.6.2.2", "type": "synonym", "evidence": [ { "id": "F1MC51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC51/entry#names_and_taxonomy" } ] }, { "name": "ABCB5 P-gp", "type": "synonym", "evidence": [ { "id": "F1MC51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC51/entry#names_and_taxonomy" } ] }, { "name": "p-glycoprotein ABCB5", "type": "synonym", "evidence": [ { "id": "F1MC51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC51/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells. 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} ] } } ], "crossref": [ { "id": "F1MC51", "url": "https://alphafold.ebi.ac.uk/entry/F1MC51", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002595", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002595", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03249", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03249", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18577", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18577", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18578", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18578", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011527", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011527", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036640", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036640", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR43394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43394:SF27", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43394:SF27", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00005", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00005", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00664", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00664", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "33147", "url": "https://www.rhea-db.org/rhea/33147", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9STC7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9STC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXM5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC51", "url": "https://www.uniprot.org/uniprotkb/F1MC51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC51-1", "url": "https://www.uniprot.org/uniprotkb/F1MC51-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANSEQAEEMQKNYQRNGTAELPKVRKQVVGPFEIFRFADGLDITLMILGLLASLVNGACLPVMSLILGEMSDNLISGCLVKTNTTNYRNCTQSQEKVNEDMIVLTLYYVGIGVTALIFGYIQISFWVMTAARQTKRIRKQFFHSVLAQDISWFDSCDIGELNTRMTEDINKINDGIGDKIALLFQNMSTFSVGLAIGLVKGWKLTLVTLSTSPLIIASAAIFSRIVISLSSKELNAYSKAGAVAEEVLSSIRTVIAFGAQEKEIQRYTQNLKDAKDVGIKKAIASKLSLGAVYFFMNGTYGLAFWYGTSLILSGEPDYTIGTVLAVFFSVIHSSYCIGAAAPNFETFTIARGAAFNIFHIIDKKPTIDNFSTTGYKLECIEGTVEFKNVSFSYPSRPSIKILKGLNLKIKSGETVALVGPNGSGKSTAVQLLQRLYDPDDGFITVDGNDIRTLNVRHYREHFGVVSQEPVLFGTTINNNIRYGQDGVTNEDIEKAAKEANAYDFIMEFPKKFNTLVGEKGIQMSGGQKQRIAIARALVRNPKILILDEATSALDTESESAVQAALVKASKGRTTIVVAHRLSTIRSADMIVTIKDGMVVEKGTHAELMTKQGLYYSLAMSQDIKKADEQIESVAYSAEKDTSSIPLCSVNSMKSDFTDKVEESTQYKETNLPEVSLLKIFKLYKSEWPSVVLGTLASVLNGTVHPIFSIIFAKIVTMFENDDKTTLKHDAEIYSMIFVILGVMCFVSYFIQGLFYGRAGEILTMRLRHLAFKAMLYQDISWFDDKENTTGALTTILAIDIAQIQGATGSRVGVLTQNATNMGLSVIISFIYGWEMTLLILSIAPVLALTGMIETAAMTGFANKDKQELLRAGKIATEAVENIRTIMSLTREKAFEQMYEETLQTQHRNTLKKAQIIGICYAFSHAFVYFAYAVGFRFGTYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSRAKSGAAHLFALLEKKPTIDSYSQEGKKTDICEGNIEFREVSFFYPSRPDVLILRSLSLSIEKGKTVAFVGSSGCGKSTSVQLLQRFYDPVKGQVLFDGVDAKELNVQWLRSQIAIVSQEPVLFNCSIAENIAYGDNSRVVSLNEIKEVANAANIHSFIESLPEKYNTHVGLKGTQLSGGQKQRLAIARALLRKPKILLLDEATSALDNESEKVVQHALDKASKGRTCLVVAHRLSTIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSVQ", "length": 1256, "header": "tr|F1MC51-1|F1MC51_BOVIN Isoform 1 of ATP-binding cassette sub-family B member 5 OS=Bos taurus OX=9913 GN=ABCB5 PE=3 SV=4 CANONICAL=F1MC51-1" }, "isoforms": [ { "isoform_ac": "A0AAA9STC7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STC7/entry", "sequence": { "sequence": "TVDGNDIRTLNVRHYREHFGVVSQEPVLFGTTINNNIRYGQDGVTNEDIEKAAKEANAYDFIMEFPKKFNTLVGEKGIQMSGGQKQRIAIARALVRNPKILILDEATSALDTESESAVQAALVKKE", "length": 126, "header": "tr|A0AAA9STC7-1|F1MC51_BOVIN Computationally mapped isoform of ATP-binding cassette sub-family B member 5 OS=Bos taurus OX=9913 GN=ABCB5 PE=3 SV=1 CANONICAL=F1MC51-1" }, "locus": { "chromosome": "4", "start_pos": 29403856, "end_pos": 29383504, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112221.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112221.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088605.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088605.1" } ] } }, { "isoform_ac": "A0AAA9SXM5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXM5/entry", "sequence": { "sequence": "TVDGNDIRTLNVRHYREHFGVVSQEPVLFGTTINNNIRYGQDGVTNEDIEKAAKEANAYDFIMEFPKKFNTLVGEKGIQMSGGQKQRIAIARALVRNPKILILDEATSALDTESESAVQAALVKGNPRYSF", "length": 131, "header": "tr|A0AAA9SXM5-1|F1MC51_BOVIN Computationally mapped isoform of ATP-binding cassette sub-family B member 5 OS=Bos taurus OX=9913 GN=ABCB5 PE=3 SV=1 CANONICAL=F1MC51-1" }, "locus": { "chromosome": "4", "start_pos": 29394079, "end_pos": 29383504, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118846.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118846.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088055.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088055.1" } ] } }, { "isoform_ac": "F1MC51-1", "url": "https://www.uniprot.org/uniprotkb/F1MC51/entry", "sequence": { "sequence": "MANSEQAEEMQKNYQRNGTAELPKVRKQVVGPFEIFRFADGLDITLMILGLLASLVNGACLPVMSLILGEMSDNLISGCLVKTNTTNYRNCTQSQEKVNEDMIVLTLYYVGIGVTALIFGYIQISFWVMTAARQTKRIRKQFFHSVLAQDISWFDSCDIGELNTRMTEDINKINDGIGDKIALLFQNMSTFSVGLAIGLVKGWKLTLVTLSTSPLIIASAAIFSRIVISLSSKELNAYSKAGAVAEEVLSSIRTVIAFGAQEKEIQRYTQNLKDAKDVGIKKAIASKLSLGAVYFFMNGTYGLAFWYGTSLILSGEPDYTIGTVLAVFFSVIHSSYCIGAAAPNFETFTIARGAAFNIFHIIDKKPTIDNFSTTGYKLECIEGTVEFKNVSFSYPSRPSIKILKGLNLKIKSGETVALVGPNGSGKSTAVQLLQRLYDPDDGFITVDGNDIRTLNVRHYREHFGVVSQEPVLFGTTINNNIRYGQDGVTNEDIEKAAKEANAYDFIMEFPKKFNTLVGEKGIQMSGGQKQRIAIARALVRNPKILILDEATSALDTESESAVQAALVKASKGRTTIVVAHRLSTIRSADMIVTIKDGMVVEKGTHAELMTKQGLYYSLAMSQDIKKADEQIESVAYSAEKDTSSIPLCSVNSMKSDFTDKVEESTQYKETNLPEVSLLKIFKLYKSEWPSVVLGTLASVLNGTVHPIFSIIFAKIVTMFENDDKTTLKHDAEIYSMIFVILGVMCFVSYFIQGLFYGRAGEILTMRLRHLAFKAMLYQDISWFDDKENTTGALTTILAIDIAQIQGATGSRVGVLTQNATNMGLSVIISFIYGWEMTLLILSIAPVLALTGMIETAAMTGFANKDKQELLRAGKIATEAVENIRTIMSLTREKAFEQMYEETLQTQHRNTLKKAQIIGICYAFSHAFVYFAYAVGFRFGTYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSRAKSGAAHLFALLEKKPTIDSYSQEGKKTDICEGNIEFREVSFFYPSRPDVLILRSLSLSIEKGKTVAFVGSSGCGKSTSVQLLQRFYDPVKGQVLFDGVDAKELNVQWLRSQIAIVSQEPVLFNCSIAENIAYGDNSRVVSLNEIKEVANAANIHSFIESLPEKYNTHVGLKGTQLSGGQKQRLAIARALLRKPKILLLDEATSALDNESEKVVQHALDKASKGRTCLVVAHRLSTIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSVQ", "length": 1256, "header": "tr|F1MC51-1|F1MC51_BOVIN Isoform 1 of ATP-binding cassette sub-family B member 5 OS=Bos taurus OX=9913 GN=ABCB5 PE=3 SV=4 CANONICAL=F1MC51-1" }, "locus": { "chromosome": "4", "start_pos": 29473183, "end_pos": 29355410, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031698.6", "url": "https://www.ensembl.org/id/ENSBTAT00000031698.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031647.6", "url": "https://www.ensembl.org/id/ENSBTAP00000031647.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-382556", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "resource": "Reactome", "description": "ABC-family protein mediated transport" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MC51", "url": "https://www.uniprot.org/uniprotkb/F1MC51" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "F1MC51", "url": "https://www.uniprot.org/uniprotkb/F1MC51" } ], "pmid": "" }, { "name": "ATPase-coupled transmembrane transporter activity", "id": "GO:0042626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042626", "evidence": [ { "database": "UniProtKB", "id": "F1MC51", "url": "https://www.uniprot.org/uniprotkb/F1MC51" } ], "pmid": "" }, { "name": "ABC-type xenobiotic transporter activity", "id": "GO:0008559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008559", "evidence": [ { "database": "UniProtKB", "id": "F1MC51", "url": "https://www.uniprot.org/uniprotkb/F1MC51" } ], "pmid": "" }, { "name": "efflux transmembrane transporter activity", "id": "GO:0015562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015562", "evidence": [ { "database": "UniProtKB", "id": "F1MC51", "url": "https://www.uniprot.org/uniprotkb/F1MC51" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MC51", "url": "https://www.uniprot.org/uniprotkb/F1MC51" } ], "pmid": "" }, { "name": "regulation of membrane potential", "id": "GO:0042391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042391", "evidence": [ { "database": "UniProtKB", "id": "F1MC51", "url": "https://www.uniprot.org/uniprotkb/F1MC51" } ], "pmid": "" }, { "name": "transmembrane transport", "id": "GO:0055085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055085", "evidence": [ { "database": "UniProtKB", "id": "F1MC51", "url": "https://www.uniprot.org/uniprotkb/F1MC51" } ], "pmid": "" }, { "name": "eye development", "id": "GO:0001654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001654", "evidence": [ { "database": "UniProtKB", "id": "F1MC51", "url": "https://www.uniprot.org/uniprotkb/F1MC51" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "F1MC51", "url": "https://www.uniprot.org/uniprotkb/F1MC51" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1103, "end_pos": 1105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1187, "end_pos": 1189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 17, "end_pos": 19, "annotation": "n_glycosylation_sequon" }, { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 389, "end_pos": 391, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 701, "end_pos": 703, "annotation": "n_glycosylation_sequon" }, { "start_pos": 788, "end_pos": 790, "annotation": "n_glycosylation_sequon" }, { "start_pos": 818, "end_pos": 820, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "33147", "name": "", "equation": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8HXQ5-1", "A0A3Q1NLJ8-1", "F1N3Y6-1", "F1MC51-1" ], "evidence": [ { "id": "33147", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33147" } ] }, { "id": "R-BTA-1467457", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MC51-1" ], "evidence": [ { "id": "R-BTA-1467457", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1467457" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1NLJ8", "gene_name": "ABCC2", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NLJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NLJ8" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NLJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NLJ8" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "A0A3Q1NLJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NLJ8" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "A0A3Q1NLJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NLJ8" } ] } ] }, { "uniprot_ac": "F1MC51", "gene_name": "ABCB5", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "F1MC51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC51" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "F1MC51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC51" } ] } ] }, { "uniprot_ac": "F1N3Y6", "gene_name": "ABCC3", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "F1N3Y6", 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"url": "https://alphafold.ebi.ac.uk/entry/F1MFG2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012111", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012111", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537500", "url": "https://www.ncbi.nlm.nih.gov/gene/537500", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537500", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537500", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YKNHKKX", "url": "https://omabrowser.org/oma/group/YKNHKKX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MFG2", "url": "https://www.orthodb.org/?gene=F1MFG2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384:SF189", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384:SF189", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24390", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24390", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24390:SF249", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24390:SF249", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394:SF29", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394:SF29", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12874", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12874", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13894", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13894", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21549", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21549", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179836", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SUJ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SY25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFG2-1", "url": "https://www.uniprot.org/uniprotkb/F1MFG2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQEGENIFYLAIEDIETDTELLIGYLDSDMEADEEEQQIMTMINEEEGKNSKGQSTASRKDRFGCKEDYACPYCESSFTSEEILAEHLQTLHQKPTEEKEYKCKSCGKKFPVKQALQRHVLQCSAKSSLKDSSRSFQCSVCNTSFSSASSFEQHQETCQGDARFVCKADSCGKRLKSKEALRRHQENVHTGDPKKKLICSVCNKKCSSASSLQEHRKIHEIFDCQECMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRLDQVGAHKVIHSEDKPYKCKLCGKGFAHRNVYKNHKKTHSEERPFQCEECKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPSVLRSHKKTHTGEKEKICPYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTREKPYKCSECGKAFSQKRGLDEHTRTHTGEKPFQCDVCDLAFSLKKMLIRHKMTHNPNRPLAECQFCHKKFTRNDYLKVHMDNIHGEADS", "length": 630, "header": "tr|F1MFG2-1|F1MFG2_BOVIN Isoform 1 of Zinc finger protein OS=Bos taurus OX=9913 GN=PRDM5 PE=3 SV=2 CANONICAL=F1MFG2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SUJ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUJ6/entry", "sequence": { "sequence": "MLGMYVPDRFSLKSSRVQDGMGLYTARRVRKVGDPAGARARPLPPRRAPLSRARGLRARRLSAGAPRGAGPAGRLPSPAPPEPAAPRRCGRARSAAGRPAARCLSSAAGSGAGCCLPPPWPRRGVVSWRWQRHARVSVSRARTQLRRLSCFRMWKCDQGRLAFPGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQEGENIFYLAIEDIETDTELLIGYLDSDMEADEEEQQIMTMINEEEGKNSKGQSTASRKDRFGCKEDYACPYCESSFTSEEILAEHLQTLHQKPTEEKEYKCKSCGKKFPVKQALQRHFEQHQETCQGDARFVCKADSCGKRLKSKEALRRHQENVHTGDPKKKLICSVCNKKCSSASSLQEHRKIHEIFDCQECMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRLDQVGAHKVIHSEDKPYKCKLCGKGFAHRNVYKNHKKTHSEERPFQCEECKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPSVLRSHKKTHTGEKEKICPYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTREKPYKCSECGKAFSQKRGLDEHTRTHTGEKPFQCDVCDLAFSLKKMLIRHKMTHNPNRPLAECQFCHKKFTRNDYLKVHMDNIHGEADS", "length": 732, "header": "tr|A0AAA9SUJ6-1|F1MFG2_BOVIN Computationally mapped isoform of Zinc finger protein OS=Bos taurus OX=9913 GN=PRDM5 PE=3 SV=1 CANONICAL=F1MFG2-1" }, "locus": { "chromosome": "6", "start_pos": 4777586, "end_pos": 4526911, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117087.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117087.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090126.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090126.1" } ] } }, { "isoform_ac": "A0AAA9SY25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SY25/entry", "sequence": { "sequence": "MLGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQEGENIFYLAIEDIETDTELLIGYLDSDMEADEEEQQIMTMINEEEGKNSKGQSTASRKDRFGCKEDYACPYCESSFTSEEILAEHLQTLHQKPTEEKEYKCKSCGKKFPVKQALQRHFEQHQETCQGDARFVCKADSCGKRLKSKEALRRHQENVHTGDPKKKLICSVCNKKCSSASSLQEHRKIHEIFDCQECMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRLDQVGAHKVIHSEDKPYKCKLCGKGFAHRNVYKNHKKTHSEERPFQCEECKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPSVLRSHKKTHTGEKEKICPYCGQKFASSGTLRVHIRSHTGEAIQVLRVRQGLQPEARPGRAHEDTHRGEAFPVRRL", "length": 518, "header": "tr|A0AAA9SY25-1|F1MFG2_BOVIN Computationally mapped isoform of Zinc finger protein OS=Bos taurus OX=9913 GN=PRDM5 PE=3 SV=1 CANONICAL=F1MFG2-1" }, "locus": { "chromosome": "6", "start_pos": 4777429, "end_pos": 4526911, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116857.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116857.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091373.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091373.1" } ] } }, { "isoform_ac": "F1MFG2-1", "url": "https://www.uniprot.org/uniprotkb/F1MFG2/entry", "sequence": { "sequence": "MLGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQEGENIFYLAIEDIETDTELLIGYLDSDMEADEEEQQIMTMINEEEGKNSKGQSTASRKDRFGCKEDYACPYCESSFTSEEILAEHLQTLHQKPTEEKEYKCKSCGKKFPVKQALQRHVLQCSAKSSLKDSSRSFQCSVCNTSFSSASSFEQHQETCQGDARFVCKADSCGKRLKSKEALRRHQENVHTGDPKKKLICSVCNKKCSSASSLQEHRKIHEIFDCQECMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRLDQVGAHKVIHSEDKPYKCKLCGKGFAHRNVYKNHKKTHSEERPFQCEECKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPSVLRSHKKTHTGEKEKICPYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTREKPYKCSECGKAFSQKRGLDEHTRTHTGEKPFQCDVCDLAFSLKKMLIRHKMTHNPNRPLAECQFCHKKFTRNDYLKVHMDNIHGEADS", "length": 630, "header": "tr|F1MFG2-1|F1MFG2_BOVIN Isoform 1 of Zinc finger protein OS=Bos taurus OX=9913 GN=PRDM5 PE=3 SV=2 CANONICAL=F1MFG2-1" }, "locus": { "chromosome": "6", "start_pos": 4777586, "end_pos": 4526911, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049757.4", "url": "https://www.ensembl.org/id/ENSBTAT00000049757.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046605.2", "url": "https://www.ensembl.org/id/ENSBTAP00000046605.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:537500", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537500", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LNR1-1", "protein_name": "Zinc finger protein", "gene_name": "Prdm5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLGMYVPDRFALKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRFVHEAPSQERKNLAAIQGQVLMRRPFVSLTPEAIAIVNSTSTEGQLHEGENIFYLAVDDIETDTELLIGYLDSDVEAEEEEQQALTMAREGKVDHSKGQLAAGSKGHLGCEEDFACPQCESSFPSEEVLTEHLQSLHQKPTGEKEFKCENCGKKFPVRQALQRHFEQHQKACRGDARFVCKVDSCGKRLKSKDALKRHRENVHTGDPKRKLICSVCNRRCTSLSSLQEHRKIHEIFDCQECMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRLDQVGAHKVIHSEDKPYQCKLCGKGFAHRNVYKNHKKTHSEERPFQCDECKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCSKAFVTPSVLRSHKKTHTGEKEKVCPYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTREKPYQCSECSKAFSQKRGLDEHKRTHTGEKPFQCDVCDLAFSLKKMLIRHKMTHNPNRPMAECHFCHKKFTRNDYLKVHMDNIHGVADS", "length": 629 }, "evidence": [ { "id": "F1MFG2", "url": "https://omabrowser.org/oma/group/F1MFG2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1Q8J8-1", "protein_name": "PR domain zinc finger protein 5", "gene_name": "prdm5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRMLGMYVPDRFVLKSSQVQDGMGLYTTRTVKKGEKFGPFAGEKRMLGDLDESMDPRLMWEVRGNKGDVLYILDASNPRHANWLRFVHQAPSQEQKNLAAIQDGENIFYLAVDDIETDTELLIGYLDSDMEEEEEDLEEEQDIKDEDENSKDSKQLSADTELMIKKEDYPCLLCESSFPSEDVLAEHLQSLHNRGSAEDKEFKCRSCGKEFPVRQALQRHLLHCTESSSSSGDPSKAYQCVLCHGSFSSQSSFLQHKEACKGDERFICKAESCGKRFKSKDALKKHKGNIHIGGARRKLVCTICNKKCSSSLNLQEHRKVHEVFDCDACDKKFISTNQLKRHMITHSEKRPYTCEICSRSFKRLDQATAHKIIHSEDKPYKCKLCWKEFAHRNVYKNHKKTHSEERPFQCEECKALFRTPFSLQRHLLIHNNERTFKCDHCDATFKRKDTLNVHIQVVHDGHKKYKCDLCEKAFVTPSVLKSHKKTHTGEKEKICPYCGQKFASNGTLRVHIRSHTGERPYQCPYCDKAFSKNDGLKMHIRTHTREKPYKCSECNKAFSQKRGLDEHMRTHTGEKPFQCDVCDLSFSLKKMLIRHKLTHNPNRPMAECSLCHKKFTRNDYLKVHMENVHGETEG", "length": 634 }, "evidence": [ { "id": "F1MFG2", "url": "https://omabrowser.org/oma/group/F1MFG2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9CXE0-1", "protein_name": "PR domain zinc finger protein 5", "gene_name": "Prdm5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLGMYVPDRFALKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRFVHEAPSQERKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSDVEAEEEEQQALTMTKEGKVDHSKGQLAAGSKGHLGCEEDFACPQCESSFPSEEVLTEHLQSLHQKPTGEKEFKCENCGKKFPVRQALQRHFEQHRKACRGEARFVCKADSCGKRLKSKDALRRHQENVHTGDPKRKLICSVCNRKCTSVSSLQEHRKIHEIFDCQECMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRLDQVGAHKVIHSEDKPYQCKLCGKGFAHRNVYKNHKKTHSEERPFQCDACKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPSVLRSHKKTHTGEKEKVCPYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTREKPYQCSECSKAFSQKRGLDEHKRTHTGEKPFQCDVCDLAFSLKKMLIRHKMTHNPNRPMAECHFCHKKFTRNDYLKVHMDNIHGVADS", "length": 599 }, "evidence": [ { "id": "F1MFG2", "url": "https://omabrowser.org/oma/group/F1MFG2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NQX1-1", "protein_name": "PR domain zinc finger protein 5", "gene_name": "PRDM5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDSDMEAEEEEQQIMTVIKEGEVENSRRQSTAGRKDRLGCKEDYACPQCESSFTSEDILAEHLQTLHQKPTEEKEFKCKNCGKKFPVKQALQRHVLQCTAKSSLKESSRSFQCSVCNSSFSSASSFEQHQETCRGDARFVCKADSCGKRLKSKDALKRHQENVHTGDPKKKLICSVCNKKCSSASSLQEHRKIHEIFDCQECMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRLDQVGAHKVIHSEDKPYKCKLCGKGFAHRNVYKNHKKTHSEERPFQCEECKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHERHKKYRCELCNKAFVTPSVLRSHKKTHTGEKEKICPYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTREKPYKCSECSKAFSQKRGLDEHKRTHTGEKPFQCDVCDLAFSLKKMLIRHKMTHNPNRPLAECQFCHKKFTRNDYLKVHMDNIHGVADS", "length": 630 }, "evidence": [ { "id": "F1MFG2", "url": "https://omabrowser.org/oma/group/F1MFG2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" }, { "name": "regulation of extracellular matrix organization", "id": "GO:1903053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903053", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" }, { "name": "methyltransferase activity", "id": "GO:0008168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor binding", "id": "GO:0140297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140297", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": "https://www.uniprot.org/uniprotkb/F1MFG2" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "F1MFG2", "url": 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"https://www.uniprot.org/uniprotkb/F1MII3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MII3", "url": "https://www.uniprot.org/uniprotkb/F1MII3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" }, { "start_pos": 620, "end_pos": 622, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MII3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 716, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MII3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MII3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MII3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MII3" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 630, "end_pos": 690, "start_aa": "Ser", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MII3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MII3" }, { "id": "PS51179", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51179" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "POU-specific", "eco_id": "ECO_0000259", "start_pos": 501, "end_pos": 611, "start_aa": "Val", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 289, 312, 397 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 173, "end_pos": 175 }, { "start_pos": 620, "end_pos": 622 }, { "start_pos": 82, "end_pos": 84 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1ME16-1", "uniprot_ac": "F1ME16", "uniprot_id": "F1ME16_BOVIN", "mass": { "chemical_mass": 53243.0, "monoisotopic_mass": 53243.0 }, "refseq": { "ac": "XP_002687186", "name": "zinc finger protein 212 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687186" }, "gene_names": [ { "name": "ZNF212", "type": "recommended", "evidence": [ { "id": "F1ME16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME16" } ] }, { "name": "ZNF212", "type": "synonym", "evidence": [ { "id": "XP_002687186", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687186" } ] } ], "protein_names": [ { "name": "Zinc finger protein 212", "type": "synonym", "evidence": [ { "id": "F1ME16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME16/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein 212 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002687186", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687186" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1ME16", "url": "https://www.uniprot.org/uniprotkb/F1ME16" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF212", "url": "https://www.uniprot.org/uniprotkb/F1ME16", "locus": { "chromosome": "4", "start_pos": 112343378, "end_pos": 112326767, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000389", "url": "https://www.ensembl.org/id/ENSBTAG00000000389" } ] } } ], "crossref": [ { "id": "F1ME16", "url": "https://alphafold.ebi.ac.uk/entry/F1ME16", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000389", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000389", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507268", "url": "https://www.ncbi.nlm.nih.gov/gene/507268", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050752", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050752", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507268", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507268", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CMRSFSC", "url": "https://omabrowser.org/oma/group/CMRSFSC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1ME16", "url": "https://www.orthodb.org/?gene=F1ME16", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24384:SF246", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24384:SF246", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13465", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002687186", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687186", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SVG3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SVG3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME16", "url": "https://www.uniprot.org/uniprotkb/F1ME16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME16-1", "url": "https://www.uniprot.org/uniprotkb/F1ME16-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAELAPARHRRKHRSSPLTSSRPPPQATEKSSYLETTEISLWTVVAAIQAMEKKVESQAARLLTLEGRAGTAEKKLADCEKTAVELGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSNGEVPKVSRSLENDGVCFSEQEWENLEDWQKELYANVMKSNYETLVSLKVLGQPEGEVELGAEMPGDLEEEESRGVHPVEEVVVKQETLYTQDSSADLPGECSGFANEQALLSPEQAELWDGQGSSILLESGPADTRLQEPTDGGRDPGSGRTLGCPPKRKCHKQLQPGRECGQGLQLRRDSAGPCGCPECEAPHPQTPSEPEASPRPRPQLKPPARKAQSLQCDACARSFRCRVSLLTHQRCHLQEAARAGHPAQERFSPNSLVALPGHIPWRRSRGSLLCGYCGKSFSHPSDLVRHQRIHTGERPYSCPECEKSFVQKQHLLQHQKIHQRERGGPALQPARPSGLL", "length": 480, "header": "tr|F1ME16-1|F1ME16_BOVIN Isoform 1 of Zinc finger protein 212 OS=Bos taurus OX=9913 GN=ZNF212 PE=3 SV=2 CANONICAL=F1ME16-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SVG3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVG3/entry", "sequence": { "sequence": "MAELAPARHRRKHRSSPLTSSRPPPQATEKSSYLETTEISLWTVVAAIQAMEKKLADCEKTAVELGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSNGEVPKVSRSLENDGVCFSEQEWENLEDWQKELYANVMKSNYETLVSLKVLGQPEGEVELGAEMPGDLEEEESRGVHPVEEVVVKQETLYTQDSSADLPGECSGFANEQALLSPEQAELWDGQGSSILLESGPADTRLQEPTDGGRDPGSGRTLGCPPKRKCHKQLQPGRECGQGLQLRRDSAGPCGCPECEAPHPQTPSEPEASPRPRPQLKPPARKAQSLQCDACARSFRCRVSLLTHQRCHLQEAARAGHPAQERFSPNSLVALPGHIPWRRSRGSLLCGYCGKSFSHPSDLVRHQRIHTGERPYSCPECEKSFVQKQHLLQHQKIHQRERGGPALQPARPSGLL", "length": 459, "header": "tr|A0AAA9SVG3-1|F1ME16_BOVIN Computationally mapped isoform of Zinc finger protein 212 OS=Bos taurus OX=9913 GN=ZNF212 PE=3 SV=1 CANONICAL=F1ME16-1" }, "locus": { "chromosome": "4", "start_pos": 112342374, "end_pos": 112326966, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097151.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097151.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090458.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090458.1" } ] } }, { "isoform_ac": "F1ME16-1", "url": "https://www.uniprot.org/uniprotkb/F1ME16/entry", "sequence": { "sequence": "MAELAPARHRRKHRSSPLTSSRPPPQATEKSSYLETTEISLWTVVAAIQAMEKKVESQAARLLTLEGRAGTAEKKLADCEKTAVELGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSNGEVPKVSRSLENDGVCFSEQEWENLEDWQKELYANVMKSNYETLVSLKVLGQPEGEVELGAEMPGDLEEEESRGVHPVEEVVVKQETLYTQDSSADLPGECSGFANEQALLSPEQAELWDGQGSSILLESGPADTRLQEPTDGGRDPGSGRTLGCPPKRKCHKQLQPGRECGQGLQLRRDSAGPCGCPECEAPHPQTPSEPEASPRPRPQLKPPARKAQSLQCDACARSFRCRVSLLTHQRCHLQEAARAGHPAQERFSPNSLVALPGHIPWRRSRGSLLCGYCGKSFSHPSDLVRHQRIHTGERPYSCPECEKSFVQKQHLLQHQKIHQRERGGPALQPARPSGLL", "length": 480, "header": "tr|F1ME16-1|F1ME16_BOVIN Isoform 1 of Zinc finger protein 212 OS=Bos taurus OX=9913 GN=ZNF212 PE=3 SV=2 CANONICAL=F1ME16-1" }, "locus": { "chromosome": "4", "start_pos": 112342374, "end_pos": 112326966, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000499.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000499.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000499.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000499.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507268", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507268", "resource": "KEGG Pathway" }, { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1ADJ0-1", "protein_name": "Zinc finger family member 767", "gene_name": "ZNF767", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASALPGSCLCSSSLPQAPGEAVPSSTASISLWTVVAAVQAVEKSVEAHASRLLNLERRTVTTEKKYLDCEKTVVDFGNQLESKLTVLGTLIREYGQLQRRLEHMENLLKNRNFCILRLPPAPKGPEASESETACFAEQEWENLEEWQKELYRNMLRGNSESLNSLDYSVSRSDLSQLQRGEAPCSEVTSAQKEVPTEPSADFSIPEPSFTGTLKQNEEVCAEEQEATEGAEFTELSVVPADEVIAFKIEQLDSDECLQSSECPTALSGESEDMFFQSANEALPFDSQFSSPVPLGNQSLSRLVPSASGEGDLGEISTVTFYRQEYPEERPHSCAACRKGLCLKKMLMMQQQNHSTLCGGEPTEDENIFIHQPHQQIHIATESFKQNLKVKAPAGISATNKARGSSRCMKSINTNRNKPGHPQGKPYKCSKCQECFSQKKTLIIHQRVHSGRSPGVLWCSYCGKTFSHPSNLIRHQRIHTEDSSIRVKEEEESCTAAQEELEAAGAVQEPCPGQTKGGTEVYSRELPGTAREDLPGDTESQTCMTAVLSWIKQEEELQCPEQQGSEKEEIPTEPGAVHDENRRDTLADSFVSTMCDSGMLERPEEKFHKDPSPALTWDSQWGSEMMETTTSRNGFGGGAQYDRAFGEHLDLFNAQQSDVRKRLCVSSGCERNYIQQEHLSALQGAQEELLPVPKCENSPIEVAFQHPVDAAGEKFEGLPAKLAPSSAGRTRLREHNGLCREDRPSVGSRGKLPAENVLSSPCEANTRDASEAPRGGLASQQQSQGKGKSYICNDCGKSFVCHSWLVRHQTSHTSERPYKCSKCDKSYRRKDYLLKHLRRHSGEGLFPCHLCSKRFVLRRSLIKHQESHVQRTHQTAIRPCAEIKESVLHSR", "length": 891 }, "evidence": [ { "id": "F1ME16", "url": "https://omabrowser.org/oma/group/F1ME16/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3V6U6-1", "protein_name": "Zinc finger protein 212", "gene_name": "Zfp212", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAESTPARHRRKRRSTPLAPATPPSQTTEKSQYFQTTEISLWTVVAAIQAVEKKMESQAARLQSLEGRAGSAEKKLADFEKTAVEFSNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNKNFWVLRLPPGSKGETPKVSGPLENDGVCFSEQEWENLEDWQKELYRNVMESNYETLVSLKVLGQPEEEVELGAEMVGDLVEEGTHLADRAMVKQEMLYKQEGPSGLPSMFSSAAEPQACFGSEQAVFWNSPGDSALLESGPGDSNPESVESSRDPAPGRNLDCPRKQKSHRQVQLGQECGQGPKVKRDTSPYKCSECQISFRYKQQLTAHLQSHTSRESYSATEPEESLRPRPRLKPQAKRSKLHQCDVCHRSFSCKVSLVTHQRCHQQEGPSTSPQIQERFSPNSLVALPGHIPWRKSRSSLICGYCGKSFSHPSDLVRHQRIHTGERPYSCPECEKSFVQKQHLLQHQKIHQRERGGLASESARPNGLL", "length": 492 }, "evidence": [ { "id": "F1ME16", "url": "https://omabrowser.org/oma/group/F1ME16/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3X8R7-1", "protein_name": "Zinc finger protein 212", "gene_name": "Zfp212", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAESTPTRHRRKRRATPLAPATPPSQTTEKSPYFQTTEISLWTVVAAIQAVEKKMESQAARLQSLEGRAGSAEKKLADFEKTAVEFSNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNKNFWVLRLPPGSKGETPKVSGSLENDGVCFSEQEWENLEDWQKELYRNVMESNYETLVSLKVLGQPEEEVELGAEMVGDLVEEGTHLADRAMVKQEMLYKQEGPAGLPNMFSSAVEQQAFFGAEQAMFWNSPGDSALLESGPGDSNPESVETSRDPAPGRNLDCPRKQKSHRQVQLGQECGQGLKVKRDSSPYKCPECQISFRYKQQLTAHLQSHAGRESYSATEPEESLRPRPRLKPQAKRSKLHQCDVCHRSFSCKVSLVTHQRCHQQEGPSTSPQIQERFSPNSLVALPGHIPWRKSRSSLICGYCGKSFSHPSDLVRHQRIHTGERPYSCPECEKSFVQKQHLLQHQKIHQRERGGLASESARPNGLL", "length": 492 }, "evidence": [ { "id": "F1ME16", "url": "https://omabrowser.org/oma/group/F1ME16/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UDV6-1", "protein_name": "Zinc finger protein 212", "gene_name": "ZNF212", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAESAPARHRRKRRSTPLTSSTLPSQATEKSSYFQTTEISLWTVVAAIQAVEKKMESQAARLQSLEGRTGTAEKKLADCEKMAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKVSRSLENDGVCFTEQEWENLEDWQKELYRNVMESNYETLVSLKVLGQTEGEAELGTEMLGDLEEEGPGGAHPAGGVMIKQELQYTQEGPADLPGEFSCIAEEQAFLSPEQTELWGGQGSSVLLETGPGDSTLEEPVGSRVPSSSRTVGCPKQKSHRQVQLDQECGQGLKLKKDTSRPYECSECEITFRYKQQLATHLRSHSGWGSCTPEEPEESLRPRPRLKPQTKKAKLHQCDVCLRSFSCKVSLVTHQRCHLQEGPSAGQHVQERFSPNSLVALPGHIPWRKSRSSLICGYCGKSFSHPSDLVRHQRIHTGERPYSCTECEKSFVQKQHLLQHQKIHQRERGGLALEPGRPNGLL", "length": 495 }, "evidence": [ { "id": "F1ME16", "url": "https://omabrowser.org/oma/group/F1ME16/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1ME16", "url": "https://www.uniprot.org/uniprotkb/F1ME16" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1ME16", "url": "https://www.uniprot.org/uniprotkb/F1ME16" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "F1ME16", "url": "https://www.uniprot.org/uniprotkb/F1ME16" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1ME16", "url": "https://www.uniprot.org/uniprotkb/F1ME16" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1ME16", "url": "https://www.uniprot.org/uniprotkb/F1ME16" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "F1ME16", "url": "https://www.uniprot.org/uniprotkb/F1ME16" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1ME16", "url": "https://www.uniprot.org/uniprotkb/F1ME16" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1ME16", "url": "https://www.uniprot.org/uniprotkb/F1ME16" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1ME16", "url": "https://www.uniprot.org/uniprotkb/F1ME16" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1ME16", "url": "https://www.uniprot.org/uniprotkb/F1ME16" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1ME16", "url": "https://www.uniprot.org/uniprotkb/F1ME16" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1ME16-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 480, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1ME16-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ME16" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1ME16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME16" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 354, "end_pos": 381, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1ME16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME16" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 141, "end_pos": 219, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MI65-1", "uniprot_ac": "F1MI65", "uniprot_id": "F1MI65_BOVIN", "mass": { "chemical_mass": 47233.0, "monoisotopic_mass": 47233.0 }, "refseq": {}, "gene_names": [ { "name": "KRT23", "type": "recommended", "evidence": [ { "id": "F1MI65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI65" } ] } ], "protein_names": [ { "name": "Keratin 23", "type": "synonym", "evidence": [ { "id": "F1MI65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI65/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MI65", "url": "https://www.uniprot.org/uniprotkb/F1MI65" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KRT23", "url": "https://www.uniprot.org/uniprotkb/F1MI65", "locus": { "chromosome": "19", "start_pos": 41114841, "end_pos": 41134104, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040460", "url": "https://www.ensembl.org/id/ENSBTAG00000040460" } ] } } ], "crossref": [ { "id": "F1MI65", "url": "https://alphafold.ebi.ac.uk/entry/F1MI65", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040460", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040460", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018039", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018039", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SCILEWH", "url": "https://omabrowser.org/oma/group/SCILEWH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MI65", "url": "https://www.orthodb.org/?gene=F1MI65", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23239:SF44", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239:SF44", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00038", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00038", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6805567", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6809371", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SXG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI65", "url": "https://www.uniprot.org/uniprotkb/F1MI65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI65-1", "url": "https://www.uniprot.org/uniprotkb/F1MI65-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNSNQSFSQKRSGSLYATGGSWGRPGSFLRAPSVHGGAGGVRISLSFSSPSCPLPEGSWRSGRGSSLLGGNEKEMMQNLNDRLATYLEKVRALEEANVKLESCILKWHQQRDSGNKQDYSQYEESISHLQEQIADGKVNNAQIILLIDNARMAVDDFSLKYENEHSFKKDLEIEVEGLRKTLDDLTIVTTDLEQEVEGMRKELILMKKRHEQEVEEHRVPNDFKVNVKVDTTPGEDLIKVLEDMRQEYEFIIKKKHQDLDTWYKQQSAAVAQEAASPTGVQSSQSDLHELKRTFQALEIDLQAQCSKKSALENMLSETQSRYSCQLQDMQQIISHYEEELTQLRHDLERQNNEYKVLLGIKTHLEKEITTYRQLLEGENGGKMEESKSNVKAPKIKAITQESVNGRIILSQVNEI", "length": 415, "header": "tr|F1MI65-1|F1MI65_BOVIN Isoform 1 of Keratin 23 OS=Bos taurus OX=9913 GN=KRT23 PE=3 SV=3 CANONICAL=F1MI65-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXG2/entry", "sequence": { "sequence": "MNSNQSFSQKRSGSLYATGGSWGRPGSFLRAPSVHGGAGGVRISLSFSSPSCPLPEGSWRSGRGSSLLGGNEKEMMQNLNDRLATYLEKVRALEEANVKLESCILKWHQQRDSGNKQDYSQYEESISHLQEQIADGKVNNAQIILLIDNARMAVDDFSLKYENEHSFKKDLEIEVEGLRKTLDDLTIVTTDLEQEVEGMRKELILMKKRHEQEVEEHRVPNDFKVNVKVDTTPGEDLIKVLEDMRQEYEFIIKKKHQDLDTWYKQQSAAVAQEAASPTGVQSSQSDLHELKRTFQALEIDLQAQCSKKSALENMLSETQSRYSCQLQDMQQIISHYEEELTQLRHDLERQNNEYKVLLGIKTHLEKEITTYRQLLEGENGGKMEESKSNVKGMGFTI", "length": 397, "header": "tr|A0AAA9SXG2-1|F1MI65_BOVIN Computationally mapped isoform of Keratin 23 OS=Bos taurus OX=9913 GN=KRT23 PE=3 SV=1 CANONICAL=F1MI65-1" }, "locus": { "chromosome": "19", "start_pos": 41134055, "end_pos": 41115057, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090655.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090655.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088765.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088765.1" } ] } }, { "isoform_ac": "F1MI65-1", "url": "https://www.uniprot.org/uniprotkb/F1MI65/entry", "sequence": { "sequence": "MNSNQSFSQKRSGSLYATGGSWGRPGSFLRAPSVHGGAGGVRISLSFSSPSCPLPEGSWRSGRGSSLLGGNEKEMMQNLNDRLATYLEKVRALEEANVKLESCILKWHQQRDSGNKQDYSQYEESISHLQEQIADGKVNNAQIILLIDNARMAVDDFSLKYENEHSFKKDLEIEVEGLRKTLDDLTIVTTDLEQEVEGMRKELILMKKRHEQEVEEHRVPNDFKVNVKVDTTPGEDLIKVLEDMRQEYEFIIKKKHQDLDTWYKQQSAAVAQEAASPTGVQSSQSDLHELKRTFQALEIDLQAQCSKKSALENMLSETQSRYSCQLQDMQQIISHYEEELTQLRHDLERQNNEYKVLLGIKTHLEKEITTYRQLLEGENGGKMEESKSNVKAPKIKAITQESVNGRIILSQVNEI", "length": 415, "header": "tr|F1MI65-1|F1MI65_BOVIN Isoform 1 of Keratin 23 OS=Bos taurus OX=9913 GN=KRT23 PE=3 SV=3 CANONICAL=F1MI65-1" }, "locus": { "chromosome": "19", "start_pos": 41134055, "end_pos": 41116831, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052645.3", "url": "https://www.ensembl.org/id/ENSBTAT00000052645.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051816.3", "url": "https://www.ensembl.org/id/ENSBTAP00000051816.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6805567", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6805567", "resource": "Reactome", "description": "Keratinization" }, { "id": "R-BTA-6809371", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6809371", "resource": "Reactome", "description": "Formation of the cornified envelope" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PQ65-1", "protein_name": "Keratin 23", "gene_name": "KRT23", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSTSQGPFQFYSGSLRGSAGCGLAQQGTSYRPPSADGASGTHTSFSSTRPLSLAAGGGASWGCFGEHHWESIFLGGNEKQTMQNLNDRLAAYLDKVRSLEAANAQLESCILEWHKTKSHGKRHDFNQYEQNVTDMQRQIEDGKITNASILLQIDNANMASEDFRLKYEAEKTRRQGVQCDLENLRKELDGLTIITTDLEMEIEGLREEHILRRKDHEEDMEANRSSQDFKVNVKVNAPPPEDLTKILAEIREDYEAIIEKNRQSLDSWYKELSTAVSLAADPNPEQVQSSENEIKDLTRTLQSLDIELQAQMSKKHMLEDTLADTRNYYAVALQNMQQTISKCEEELSQLRHDIRQQHNQYRVLLGIKTRLEKEISTYRLLLEGNVDRITRTCESKAEEYAELTNGKIKAIVHDSMNGQLLSSTTAIHQEE", "length": 431 }, "evidence": [ { "id": "F1MI65", "url": "https://omabrowser.org/oma/group/F1MI65/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8I5ZLV8-1", "protein_name": "Keratin 23", "gene_name": "Krt23", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNSSHSFNQTYSASVHSLGSTWGQRGSCHRTPSVHGGAGGVRISLSFTTPGCLPPGGSWGSGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANSKLESRILQWHQEREPSTKKDYSQYEENISHLQEQIVDGKMANAHIVVLIDNARMAVDDFNLKFENEHSLKKDLEIEVEGLRKTLDDLTIVTTDLEQEVEGMRKELILMKKRHEQEMEENHWPSDFKVNVKVDTTPGEDLIKVLEDMRQEYELIIKKKHQELDTWFREQSASMAQGVASPVPVQGSQSDIHELRRTFQALEIDLQAQHNRKSALENMLTETQARYSCRLQDMQQIISHYEEELIQLRQDLERQNNEHKVLLGIKTHLEKEIATYRRLLEGDTEGTRDEPESRLKGSPASMIKAITQESVNGRIVLSQVNEIQKHL", "length": 422 }, "evidence": [ { "id": "F1MI65", "url": "https://omabrowser.org/oma/group/F1MI65/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99PS0-1", "protein_name": "Keratin, type I cytoskeletal 23", "gene_name": "Krt23", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSSHSFNQTYSASVHSLGSTRGRQGSCHRAPSVHGGAGGVRISLSFTTPGCLPPGGSWGSGRSSPLLGGNGKATMQNLNDRLATYLEKVRALEEANSKLETRILRWHQEREPSHRKDYSQYEENISRLQEQIVDGKMANAHIVVLIDNARMAVDDFNLKFENEHSLKKDLEIEVEGLRKTLDDLTIVTTDLEQEVEGMRKELILMKKRHEQEMEENHLPSDFKVSVKVDTTPGEDLIKVLEDMRQEYELIIKKKHQELDTWFREQSAAMAQEVASPAPVQGNQSDIHELRRTFQALEIDLQAQHSRKTALENMLTETRARYSCRLQDMQQIISHYEEELIQLRQDLERQNNEHKVLLGIKTHLEKEIATYRRLLEGDTEGTMDGSESRLKGSEASTIKAITQESVNGRIVLSQVNEIQKHI", "length": 422 }, "evidence": [ { "id": "F1MI65", "url": "https://omabrowser.org/oma/group/F1MI65/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9C075-1", "protein_name": "Keratin, type I cytoskeletal 23", "gene_name": "KRT23", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNSGHSFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWGSGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYSQYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAASPATVQSRQGDIHELKRTFQALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRRLLEGESEGTREESKSSMKVSATPKIKAITQETINGRLVLCQVNEIQKHA", "length": 422 }, "evidence": [ { "id": "F1MI65", "url": "https://omabrowser.org/oma/group/F1MI65/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "intermediate filament", "id": "GO:0005882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005882", "evidence": [ { "database": "UniProtKB", "id": "F1MI65", "url": "https://www.uniprot.org/uniprotkb/F1MI65" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "F1MI65", "url": "https://www.uniprot.org/uniprotkb/F1MI65" } ], "pmid": "" }, { "name": "keratin filament", "id": "GO:0045095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045095", "evidence": [ { "database": "UniProtKB", "id": "F1MI65", "url": "https://www.uniprot.org/uniprotkb/F1MI65" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "F1MI65", "url": "https://www.uniprot.org/uniprotkb/F1MI65" } ], "pmid": "" }, { "name": "structural constituent of skin epidermis", "id": "GO:0030280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030280", "evidence": [ { "database": "UniProtKB", "id": "F1MI65", "url": "https://www.uniprot.org/uniprotkb/F1MI65" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "epithelial cell differentiation", "id": "GO:0030855", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030855", "evidence": [ { "database": "UniProtKB", "id": "F1MI65", "url": "https://www.uniprot.org/uniprotkb/F1MI65" } ], "pmid": "" }, { "name": "intermediate filament organization", "id": "GO:0045109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045109", "evidence": [ { "database": "UniProtKB", "id": "F1MI65", "url": "https://www.uniprot.org/uniprotkb/F1MI65" } ], "pmid": "" }, { "name": "morphogenesis of an epithelium", "id": "GO:0002009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002009", "evidence": [ { "database": "UniProtKB", "id": "F1MI65", "url": "https://www.uniprot.org/uniprotkb/F1MI65" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MI65-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 415, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MI65-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MI65" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MI65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI65" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 72, "end_pos": 382, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 4, "end_pos": 6 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.", "evidence": [ { "database": "UniProtKB", "id": "F1MGI7", "url": "https://www.uniprot.org/uniprotkb/F1MGI7#function" }, { "database": "UniProtKB", "id": "ARBA00054691", "url": "https://www.uniprot.org/uniprotkb/ARBA00054691#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MGI7", "url": "https://www.uniprot.org/uniprotkb/F1MGI7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL22RA2", "url": "https://www.uniprot.org/uniprotkb/F1MGI7", "locus": { "chromosome": "9", "start_pos": 75054412, "end_pos": 75073856, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017000", "url": "https://www.ensembl.org/id/ENSBTAG00000017000" } ] } } ], "crossref": [ { "id": "F1MGI7", "url": "https://alphafold.ebi.ac.uk/entry/F1MGI7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017000", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017000", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533061", "url": "https://www.ncbi.nlm.nih.gov/gene/533061", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015373", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015373", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533061", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533061", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SMENYYE", "url": "https://omabrowser.org/oma/group/SMENYYE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGI7", "url": "https://www.orthodb.org/?gene=F1MGI7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20859", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20859", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20859:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20859:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01108", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01108", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09294", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09294", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8854691", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854691", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010806925", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010806925", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T0L9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0L9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0L9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGI7", "url": "https://www.uniprot.org/uniprotkb/F1MGI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGI7-1", "url": "https://www.uniprot.org/uniprotkb/F1MGI7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTPKCCFLGFLLSVLLPGVVETQPANESLKPQRVHFQSRNFHNILRWQPGQACLGNNSIYFVQYKMYGERQWKNKETCWGIREFFCDLTNETSDIWEPYYGRVKTALAGIHSGWTMTQRFIPWWETKIDPPVMNITHVNGSLLVNLHAPNLPYRDQEGENVSMEYYELVYRVFIFNNSLEKEQKVYEGAHRVVEIKVTSPHTGYCVVAELYQPMLDRKSQRSRERCMETP", "length": 230, "header": "tr|F1MGI7-1|F1MGI7_BOVIN Isoform 1 of Interleukin-22 receptor subunit alpha-2 OS=Bos taurus OX=9913 GN=IL22RA2 PE=3 SV=3 CANONICAL=F1MGI7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T0L9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0L9/entry", "sequence": { "sequence": "MTPKCCFLGFLLSVLLPGVVETQPANESLKPQRVHFQSRNFHNILRWQPGQACLGNNSIYFVQYKMYGERQWKNKETCWGIREFFCDLTNETSDIWEPYYGRVKTALAGIHSGWTMTQRFIPWWERAKGV", "length": 130, "header": "tr|A0AAA9T0L9-1|F1MGI7_BOVIN Computationally mapped isoform of Interleukin-22 receptor subunit alpha-2 OS=Bos taurus OX=9913 GN=IL22RA2 PE=3 SV=1 CANONICAL=F1MGI7-1" }, "locus": { "chromosome": "9", "start_pos": 75073840, "end_pos": 75054619, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120312.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120312.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089196.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089196.1" } ] } }, { "isoform_ac": "F1MGI7-1", "url": "https://www.uniprot.org/uniprotkb/F1MGI7/entry", "sequence": { "sequence": "MTPKCCFLGFLLSVLLPGVVETQPANESLKPQRVHFQSRNFHNILRWQPGQACLGNNSIYFVQYKMYGERQWKNKETCWGIREFFCDLTNETSDIWEPYYGRVKTALAGIHSGWTMTQRFIPWWETKIDPPVMNITHVNGSLLVNLHAPNLPYRDQEGENVSMEYYELVYRVFIFNNSLEKEQKVYEGAHRVVEIKVTSPHTGYCVVAELYQPMLDRKSQRSRERCMETP", "length": 230, "header": "tr|F1MGI7-1|F1MGI7_BOVIN Isoform 1 of Interleukin-22 receptor subunit alpha-2 OS=Bos taurus OX=9913 GN=IL22RA2 PE=3 SV=3 CANONICAL=F1MGI7-1" }, "locus": { "chromosome": "9", "start_pos": 75073840, "end_pos": 75054486, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022606.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022606.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022606.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022606.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533061", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533061", "resource": "KEGG Pathway" }, { "id": "R-BTA-8854691", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854691", "resource": "Reactome", "description": "Interleukin-20 family signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7FFK5-1", "protein_name": "Interleukin-22 receptor subunit alpha-2", "gene_name": "Il22ra2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPNHCFLGFFIMSFLISAKGIQPTHGSLKPQKVQFQSRNFHNILRWQPGSSLTTNGSVYFVQYKMYGQREWKNKTDCWGTTALFCDLTNETLELYEPYYGRVMTAWAGSYSAWSRTPRFTPWWETKLDPPVVTTVQVNASLLVLLRAPELPYRNQNGKNTSMENYYDLVYRVFITDNSLQKEQKAYEGTQKTVQIESLTPRSGYCIVAEIYQPMLDKKSPRSEQRCVQIP", "length": 230 }, "evidence": [ { "id": "F1MGI7", "url": "https://omabrowser.org/oma/group/F1MGI7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q7TNI4-1", "protein_name": "Interleukin-22 receptor subunit alpha-2", "gene_name": "Il22ra2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKHCFLGLLIMLLTTATETQPAHVSLKPQKVQFQSRNFHNILHWQPGNSLTSNGSVYFVQYKTYGQGQWKDKNDCWGTTALFCDLTKETLDPYEPYYGRVMMAWAGSYSEWTRTPRFTPWWETKLDPPVVTITRVNASLRVRLRPPELPHRNQTGKNTSMENYYNLVYRVSIINNSLEKEQKAYEGTQRAVEIQGLTPHCSYCVVAEMYQPMFDRRSPRSKERCVQIP", "length": 229 }, "evidence": [ { "id": "F1MGI7", "url": "https://omabrowser.org/oma/group/F1MGI7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80XF5-1", "protein_name": "Interleukin-22 receptor subunit alpha-2", "gene_name": "Il22ra2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMPKHCLLGLLIILLSSATEIQPARVSLTPQKVRFQSRNFHNILHWQAGSSLPSNNSIYFVQYKMYGQSQWEDKVDCWGTTALFCDLTNETLDPYELYYGRVMTACAGRHSAWTRTPRFTPWWETKLDPPVVTITRVNASLRVLLRPPELPNRNQSGKNASMETYYGLVYRVFTINNSLEKEQKAYEGTQRAVEIEGLIPHSSYCVVAEMYQPMFDRRSPRSKERCVHIP", "length": 230 }, "evidence": [ { "id": "F1MGI7", "url": "https://omabrowser.org/oma/group/F1MGI7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q969J5-1", "protein_name": "Interleukin-22 receptor subunit alpha-2", "gene_name": "IL22RA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMPKHCFLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNSSVYFVQYKIMFSCSMKSSHQKPSGCWQHISCNFPGCRTLAKYGQRQWKNKEDCWGTQELSCDLTSETSDIQEPYYGRVRAASAGSYSEWSMTPRFTPWWETKIDPPVMNITQVNGSLLVILHAPNLPYRYQKEKNVSIEDYYELLYRVFIINNSLEKEQKVYEGAHRAVEIEALTPHSSYCVVAEIYQPMLDRRSQRSEERCVEIP", "length": 263 }, "evidence": [ { "id": "F1MGI7", "url": "https://omabrowser.org/oma/group/F1MGI7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1MGI7", "url": "https://www.uniprot.org/uniprotkb/F1MGI7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MGI7", "url": "https://www.uniprot.org/uniprotkb/F1MGI7" } ], "pmid": "" }, { 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"tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MBP8-1", "uniprot_ac": "F1MBP8", "uniprot_id": "F1MBP8_BOVIN", "mass": { "chemical_mass": 37565.0, "monoisotopic_mass": 37565.0 }, "refseq": { "ac": "NP_001179068", "name": "COP9 signalosome complex subunit 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179068" }, "gene_names": [ { "name": "COPS5", "type": "recommended", "evidence": [ { "id": "F1MBP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ] }, { "name": "COPS5", "type": "synonym", "evidence": [ { "id": "NP_001179068", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179068" } ] } ], "protein_names": [ { "name": "COP9 signalosome complex subunit 5", "type": "recommended", "evidence": [ { "id": "F1MBP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBP8/entry#names_and_taxonomy" } ] }, { "name": "COP9 constitutive photomorphogenic homolog subunit 5", "type": 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"locus": { "chromosome": "14", "start_pos": 31193333, "end_pos": 31213212, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002784", "url": "https://www.ensembl.org/id/ENSBTAG00000002784" } ] } } ], "crossref": [ { "id": "F1MBP8", "url": "https://alphafold.ebi.ac.uk/entry/F1MBP8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002784", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002784", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08069", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08069", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507179", "url": "https://www.ncbi.nlm.nih.gov/gene/507179", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000555", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000555", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037518", "url": 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] }, { "id": "PF01398", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01398", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18323", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18323", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5696394", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696394", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6781823", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6781823", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9929356", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929356", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179068", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T0R6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0R6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0R6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0R6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7H4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7H4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7H4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7H4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1B8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1B8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U1B8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1B8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBP8-1", "url": "https://www.uniprot.org/uniprotkb/F1MBP8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASGSGMAQKTWELANNMQEAQSVDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS", "length": 334, "header": "tr|F1MBP8-1|F1MBP8_BOVIN Isoform 1 of COP9 signalosome complex subunit 5 OS=Bos taurus OX=9913 GN=COPS5 PE=3 SV=2 CANONICAL=F1MBP8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T0R6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0R6/entry", "sequence": { "sequence": "MAASGSGMAQKTWELANNMQEAQSVDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTPTRLLCPWDSPGKNTGVGCQALLQGIFPTQGSNPCFFRSDHISRSVVSGSLRPHESQHARPPCPSPTSGVHSDSRPSSL", "length": 336, "header": "tr|A0AAA9T0R6-1|F1MBP8_BOVIN Computationally mapped isoform of COP9 signalosome complex subunit 5 OS=Bos taurus OX=9913 GN=COPS5 PE=3 SV=1 CANONICAL=F1MBP8-1" }, "locus": { "chromosome": "14", "start_pos": 31212589, "end_pos": 31199780, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092900.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092900.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090134.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090134.1" } ] } }, { "isoform_ac": "A0AAA9T7H4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7H4/entry", "sequence": { "sequence": "MAEAEPAQNEQGGTIPVSGITLHALLPVQKAIPFPSHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS", "length": 322, "header": "tr|A0AAA9T7H4-1|F1MBP8_BOVIN Computationally mapped isoform of COP9 signalosome complex subunit 5 OS=Bos taurus OX=9913 GN=COPS5 PE=3 SV=1 CANONICAL=F1MBP8-1" }, "locus": { "chromosome": "14", "start_pos": 31213013, "end_pos": 31193493, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117755.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117755.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092713.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092713.1" } ] } }, { "isoform_ac": "A0AAA9U1B8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1B8/entry", "sequence": { "sequence": "MAASGSGMAQKTWELANNMQEAQSVDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTRQVC", "length": 261, "header": "tr|A0AAA9U1B8-1|F1MBP8_BOVIN Computationally mapped isoform of COP9 signalosome complex subunit 5 OS=Bos taurus OX=9913 GN=COPS5 PE=3 SV=1 CANONICAL=F1MBP8-1" }, "locus": { "chromosome": "14", "start_pos": 31212589, "end_pos": 31200878, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094344.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094344.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103566.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103566.1" } ] } }, { "isoform_ac": "F1MBP8-1", "url": "https://www.uniprot.org/uniprotkb/F1MBP8/entry", "sequence": { "sequence": "MAASGSGMAQKTWELANNMQEAQSVDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS", "length": 334, "header": "tr|F1MBP8-1|F1MBP8_BOVIN Isoform 1 of COP9 signalosome complex subunit 5 OS=Bos taurus OX=9913 GN=COPS5 PE=3 SV=2 CANONICAL=F1MBP8-1" }, "locus": { "chromosome": "14", "start_pos": 31212589, "end_pos": 31193493, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003609.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003609.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003609.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003609.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:507179", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507179", "resource": "KEGG Pathway" }, { "id": "R-BTA-5696394", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696394", "resource": "Reactome", "description": "DNA Damage Recognition in GG-NER" }, { "id": "R-BTA-6781823", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6781823", "resource": "Reactome", "description": "Formation of TC-NER Pre-Incision Complex" }, { "id": "R-BTA-8856825", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8856825", "resource": "Reactome", "description": "Cargo recognition for clathrin-mediated endocytosis" }, { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-9929356", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9929356", "resource": "Reactome", "description": "GSK3B-mediated proteasomal degradation of PD-L1(CD274)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A976-1", "protein_name": "COP9 signalosome complex subunit 5", "gene_name": "COPS5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSHSFLGVEDTAQNQVPCTLKLRVKRKTSRCHGCLESLVPVCTCGGVGLKPTPGNLARLKLRLGCRGNNFSESSAMAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS", "length": 409 }, "evidence": [ { "id": "F1MBP8", "url": "https://omabrowser.org/oma/group/F1MBP8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "F7EUU4-1", "protein_name": "COP9 signalosome complex subunit 5", "gene_name": "Cops5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVWTNVTSGLKCHGCLESLVSVHPWWGRCKARTLRPSRIKLHLGCGDYSFSGPSAMTASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINVA", "length": 389 }, "evidence": [ { "id": "F1MBP8", "url": "https://omabrowser.org/oma/group/F1MBP8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O35864-1", "protein_name": "COP9 signalosome complex subunit 5", "gene_name": "Cops5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINVA", "length": 334 }, "evidence": [ { "id": "F1MBP8", "url": "https://omabrowser.org/oma/group/F1MBP8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54PF3-1", "protein_name": "COP9 signalosome complex subunit 5", "gene_name": "csn5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSKNGAADALKTFELENNIQTIDHDQLFKYDPQQYQQFLQSKPWSKDPHYFKHVKISAIALLKMVMHARSGGKLEVMGMLMGKVENNTMIIMDSFALPVEGTETRVNAQVEAYEYMVEYLELIKQTGRLENALGWYHSHPGYGCWLSGIDVGTQSVNQQYSEPWLGIVIDPTRTVSAGKVEIGAFRTYPQGYKPPNEGPSEYQSIPLSKIEDFGVHCKQYYSLEITYFKSSLDQQLLDKLWNKYWVNTLSSSPIFSNRDYITGQINDLSEKLEQAETQLSHSRSSILDKKKEESLLSKVSKDSSKVTIEQVQGIMSQVFKNSIFNECQTTKQ", "length": 332 }, "evidence": [ { "id": "F1MBP8", "url": "https://omabrowser.org/oma/group/F1MBP8/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6PC30-1", "protein_name": "COP9 signalosome complex subunit 5", "gene_name": "cops5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAGSSIAMKTWELSNSMQEVQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKLSALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQAEAQLGRGSFMLGLDTHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQVNTSAN", "length": 334 }, "evidence": [ { "id": "F1MBP8", "url": "https://omabrowser.org/oma/group/F1MBP8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q8LAZ7-1", "protein_name": "COP9 signalosome complex subunit 5a", "gene_name": "CSN5A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEGSSSAIARKTWELENNILPVEPTDSASDSIFHYDDASQAKIQQEKPWASDPNYFKRVHISALALLKMVVHARSGGTIEIMGLMQGKTEGDTIIVMDAFALPVEGTETRVNAQSDAYEYMVEYSQTSKLAGRLENVVGWYHSHPGYGCWLSGIDVSTQMLNQQYQEPFLAVVIDPTRTVSAGKVEIGAFRTYPEGHKISDDHVSEYQTIPLNKIEDFGVHCKQYYSLDITYFKSSLDSHLLDLLWNKYWVNTLSSSPLLGNGDYVAGQISDLAEKLEQAESQLANSRYGGIAPAGHQRRKEDEPQLAKITRDSAKITVEQVHGLMSQVIKDILFNSARQSKKSADDSSDPEPMITS", "length": 357 }, "evidence": [ { "id": "F1MBP8", "url": "https://omabrowser.org/oma/group/F1MBP8/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q92905-1", "protein_name": "COP9 signalosome complex subunit 5", "gene_name": "COPS5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS", "length": 334 }, "evidence": [ { "id": "F1MBP8", "url": "https://omabrowser.org/oma/group/F1MBP8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9XZ58-1", "protein_name": "COP9 signalosome complex subunit 5", "gene_name": "CSN5", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDSDAAQKTWELENNIQTLPSCDEIFRYDAEQQRQIIDAKPWEKDPHFFKDIKISALALLKMVMHARSGGTLEVMGLMLGKVEDNTMIVMDAFALPVEGTETRVNAQAQAYEYMTAYMEAAKEVGRMEHAVGWYHSHPGYGCWLSGIDVSTQMLNQTYQEPFVAIVVDPVRTVSAGKVCLGAFRTYPKGYKPPNEEPSEYQTIPLNKIEDFGVHCKQYYPLEISYFKSALDRRLLDSLWNKYWVNTLGSSGLLTNTEYTTGQIMDLSEKLEQSENFLGRGTDVNEKRSEDKLSKATRDCSRSTIELIHGLMAQIVKDKLFNKVGLGK", "length": 327 }, "evidence": [ { "id": "F1MBP8", "url": "https://omabrowser.org/oma/group/F1MBP8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "macrophage migration inhibitory factor binding", "id": "GO:0035718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035718", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "metal-dependent deubiquitinase activity", "id": "GO:0140492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140492", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "metallopeptidase activity", "id": "GO:0008237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008237", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "deNEDDylase activity", "id": "GO:0019784", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019784", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "regulation of IRE1-mediated unfolded protein response", "id": "GO:1903894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903894", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "exosomal secretion", "id": "GO:1990182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990182", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "protein deneddylation", "id": "GO:0000338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000338", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "regulation of JNK cascade", "id": "GO:0046328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046328", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "synaptic vesicle", "id": "GO:0008021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008021", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "COP9 signalosome", "id": "GO:0008180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008180", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MBP8", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MBP8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 334, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MBP8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MBP8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MBP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBP8" }, { "id": "PS50249", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50249" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MPN", "eco_id": "ECO_0000259", "start_pos": 55, "end_pos": 192, "start_aa": "Cys", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 332, "end_pos": 334 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", 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0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPI1-1", "uniprot_ac": "E1BPI1", "uniprot_id": "E1BPI1_BOVIN", "mass": { "chemical_mass": 70065.0, "monoisotopic_mass": 70065.0 }, "refseq": { "ac": "NP_001193832", "name": "sodium- and chloride-dependent GABA transporter 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193832" }, "gene_names": [ { "name": "SLC6A11", "type": "recommended", "evidence": [ { "id": "E1BPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI1" } ] }, { "name": "SLC6A11", "type": "synonym", "evidence": [ { "id": "NP_001193832", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193832" } ] } ], "protein_names": [ { "name": "Transporter", "type": "recommended", "evidence": [ { "id": "E1BPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI1/entry#names_and_taxonomy" } ] }, { "name": "sodium- and chloride-dependent GABA transporter 3", "type": "synonym", "evidence": [ { "id": "NP_001193832", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193832" } ] }, { "name": "solute carrier family 6 (neurotransmitter transporter, GABA), member 11", "type": "synonym", "evidence": [ { "id": "NP_001193832", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193832" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPI1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC6A11", "url": "https://www.uniprot.org/uniprotkb/E1BPI1", "locus": { "chromosome": "22", "start_pos": 54984793, "end_pos": 54859524, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038962", "url": "https://www.ensembl.org/id/ENSBTAG00000038962" } ] } } ], "crossref": [ { "id": "E1BPI1", "url": "https://alphafold.ebi.ac.uk/entry/E1BPI1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038962", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038962", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11508", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11508", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616071", "url": "https://www.ncbi.nlm.nih.gov/gene/616071", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "499109", "url": "https://www.iedb.org/epitope/499109", "database": "IEDB", "categories": [ "Other" ] }, { "id": "499110", "url": "https://www.iedb.org/epitope/499110", "database": "IEDB", "categories": [ "Other" ] }, { "id": "IPR000175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002982", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002982", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616071", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616071", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KRWKYAG", "url": "https://omabrowser.org/oma/group/KRWKYAG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPI1", "url": "https://www.orthodb.org/?gene=E1BPI1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11616", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11616:SF124", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616:SF124", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00209", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00209", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-442660", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442660", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-71288", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71288", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-888593", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-888593", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193832", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T1C7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1C7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1C7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1C7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPI1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPI1-1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTAEKALPLGNGKAAEEARESEVLSGGGGGGGGAVSARDKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFATELPWATCGHEWNTENCVEFQKLNATNHSHVSLQNATSPVMEFWERRVLAISDGIEHIGDLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYVMLLILLIRGVTLPGASEGVKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVTSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPVWVCIKVWKTEGTLPERFRKLMIPSADLKMRGMLGAGPRTVAVNDCDAKLKGDGTVAAITEKETHF", "length": 630, "header": "tr|E1BPI1-1|E1BPI1_BOVIN Isoform 1 of Transporter OS=Bos taurus OX=9913 GN=SLC6A11 PE=3 SV=3 CANONICAL=E1BPI1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1C7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1C7/entry", "sequence": { "sequence": "MTAEKALPLGNGKAAEEARESEVLSGGGGGGGGAVSARDKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFATELPWATCGHEWNTENCVEFQKLNATNHSHVSLQNATSPVMEFWERRVLAISDGIEHIGDLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYVMLLILLIRGVTLPGASEGVKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVTSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGHLHFLPGQIQAPQVQQRVHLPRLGLRHRLAHGPVLHALHPGLGLHQGVEDRGDAAREIPQVDDPQRRPENAGHAWGRPTDGGG", "length": 573, "header": "tr|A0AAA9T1C7-1|E1BPI1_BOVIN Computationally mapped isoform of Transporter OS=Bos taurus OX=9913 GN=SLC6A11 PE=3 SV=1 CANONICAL=E1BPI1-1" }, "locus": { "chromosome": "22", "start_pos": 54982468, "end_pos": 54859564, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109114.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109114.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090202.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090202.1" } ] } }, { "isoform_ac": "E1BPI1-1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1/entry", "sequence": { "sequence": "MTAEKALPLGNGKAAEEARESEVLSGGGGGGGGAVSARDKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFATELPWATCGHEWNTENCVEFQKLNATNHSHVSLQNATSPVMEFWERRVLAISDGIEHIGDLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYVMLLILLIRGVTLPGASEGVKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVTSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPVWVCIKVWKTEGTLPERFRKLMIPSADLKMRGMLGAGPRTVAVNDCDAKLKGDGTVAAITEKETHF", "length": 630, "header": "tr|E1BPI1-1|E1BPI1_BOVIN Isoform 1 of Transporter OS=Bos taurus OX=9913 GN=SLC6A11 PE=3 SV=3 CANONICAL=E1BPI1-1" }, "locus": { "chromosome": "22", "start_pos": 54982538, "end_pos": 54859564, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000038826.5", "url": "https://www.ensembl.org/id/ENSBTAT00000038826.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000038635.5", "url": "https://www.ensembl.org/id/ENSBTAP00000038635.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "High-resolution analysis of the murine MHC class II immunopeptidome.", "journal": "European journal of immunology", "date": "2016-02", "authors": "Sofron Adriana, Ritz Danilo, Neri Dario, Fugmann Tim", "evidence": [ { "database": "IEDB", "id": "499109", "url": "https://www.iedb.org/epitope/499109" }, { "database": "IEDB", "id": "499110", "url": "https://www.iedb.org/epitope/499110" } ], "reference": [ { "type": "PubMed", "id": "26495903", "url": "https://glygen.org/publication/PubMed/26495903" } ] } ], "pathway": [ { "id": "bta:616071", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616071", "resource": "KEGG Pathway" }, { "id": "R-BTA-442660", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-442660", "resource": "Reactome", "description": "SLC-mediated transport of neurotransmitters" }, { "id": "R-BTA-71288", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71288", "resource": "Reactome", "description": "Creatine metabolism" }, { "id": "R-BTA-888593", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-888593", "resource": "Reactome", "description": "Reuptake of GABA" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480E2J0-1", "protein_name": "Transporter", "gene_name": "SLC6A11", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTAEKALPLGNGKAAEEARESEVLGGGGGGSAASARDPRDRRDKAVHERGQWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNHSYVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYVMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWVFIKLWKTEGTLPEKFQKLTVPSADLKMRGKLGAGPRTVTVNDCEAKLKGDGTIAAITEKETHF", "length": 631 }, "evidence": [ { "id": "E1BPI1", "url": "https://omabrowser.org/oma/group/E1BPI1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P31647-1", "protein_name": "Sodium- and chloride-dependent GABA transporter 3", "gene_name": "Slc6a11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTAEQALPLGNGKAAEEARGSEALGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIVSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRMVTVNDCEAKVKGDGTISAITEKETHF", "length": 627 }, "evidence": [ { "id": "E1BPI1", "url": "https://omabrowser.org/oma/group/E1BPI1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P31650-1", "protein_name": "Sodium- and chloride-dependent GABA transporter 3", "gene_name": "Slc6a11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTAEQALPLGNGKAAEEARGSETLGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRTVTVNDCEAKVKGDGTISAITEKETHF", "length": 627 }, "evidence": [ { "id": "E1BPI1", "url": "https://omabrowser.org/oma/group/E1BPI1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P48066-1", "protein_name": "Sodium- and chloride-dependent GABA transporter 3", "gene_name": "SLC6A11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF", "length": 632 }, "evidence": [ { "id": "E1BPI1", "url": "https://omabrowser.org/oma/group/E1BPI1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "E1BPI1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BPI1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "E1BPI1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1" } ], "pmid": "" }, { "name": "cell projection", "id": "GO:0042995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "evidence": [ { "database": "UniProtKB", "id": "E1BPI1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "E1BPI1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1" } ], "pmid": "" }, { "name": "symporter activity", "id": "GO:0015293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015293", "evidence": [ { "database": "UniProtKB", "id": "E1BPI1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1" } ], "pmid": "" }, { "name": "gamma-aminobutyric acid:sodium:chloride symporter activity", "id": "GO:0005332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005332", "evidence": [ { "database": "UniProtKB", "id": "E1BPI1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1" } ], "pmid": "" }, { "name": "taurine:sodium symporter activity", "id": "GO:0005369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005369", "evidence": [ { "database": "UniProtKB", "id": "E1BPI1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "E1BPI1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1" } ], "pmid": "" }, { "name": "sodium ion transmembrane transport", "id": "GO:0035725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035725", "evidence": [ { "database": "UniProtKB", "id": "E1BPI1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1" } ], "pmid": "" }, { "name": "neurotransmitter uptake", "id": "GO:0001504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001504", "evidence": [ { "database": "UniProtKB", "id": "E1BPI1", "url": "https://www.uniprot.org/uniprotkb/E1BPI1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPI1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 630, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPI1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPI1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 185, "end_pos": 187 }, { "start_pos": 188, "end_pos": 190 }, { "start_pos": 196, "end_pos": 198 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BQ07-1", "uniprot_ac": "E1BQ07", "uniprot_id": "E1BQ07_BOVIN", "mass": { "chemical_mass": 46876.0, "monoisotopic_mass": 46876.0 }, "refseq": {}, "gene_names": [ { "name": "TMPRSS11A", "type": "recommended", "evidence": [ { "id": "E1BQ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ07" } ] } ], "protein_names": [ { "name": "Transmembrane protease serine", "type": "recommended", "evidence": [ { "id": "E1BQ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ07/entry#names_and_taxonomy" } ] }, { "name": "3.4.21.-", "type": "synonym", "evidence": [ { "id": "E1BQ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ07/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BQ07", "url": "https://www.uniprot.org/uniprotkb/E1BQ07" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TMPRSS11A", "url": "https://www.uniprot.org/uniprotkb/E1BQ07", "locus": { "chromosome": "6", "start_pos": 83613944, "end_pos": 83677120, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020298", "url": "https://www.ensembl.org/id/ENSBTAG00000020298" } ] } } ], "crossref": [ { "id": "E1BQ07", "url": "https://alphafold.ebi.ac.uk/entry/E1BQ07", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020298", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020298", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00190", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517049", "url": "https://www.ncbi.nlm.nih.gov/gene/517049", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001254", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001314", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009003", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017329", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017329", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018114", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24252:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24252:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00089", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00089", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01390", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01390", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T1G9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1G9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1G9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1G9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BQ07", "url": "https://www.uniprot.org/uniprotkb/E1BQ07", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BQ07-1", "url": "https://www.uniprot.org/uniprotkb/E1BQ07-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "IMYRAAVFDTGSRGLKPWMIALLIVLLLTVVAVAIGLLVHFLVSDQKMEYYHATFKISDLRGNGNSRQNSPYRFMELREISENLVDETFIDSALNKHYIKNQVVKLTPEEDGMTVDVIMVFQFPSAESSAVRNRKIRSILDEKIRNTRALSINTSSVEVNAMSSSTGKLTVQACCGKRVVPLVSNRIMSGEIAGKAAWPWQASLQHNKIHQCGATLISNTWLVTAAHCFKNKENPHQWTVSFGTKINPPLMKRNIKRIIVHERYSSPAREYDIAVVQFSPRVSFTDDIRRICLPEASASFQPNSTVYITGFGALFYGGESQNDLREARLKIISDDVCKQPHVYGSDIKFGMMCAGYLEGIYDACRGDSGGPLVGKDFKDTWYLIGIVSWGDNCGQRNKPGVYTKVTYYRNWIASKTGL", "length": 418, "header": "tr|E1BQ07-1|E1BQ07_BOVIN Isoform 1 of Transmembrane protease serine OS=Bos taurus OX=9913 GN=TMPRSS11A PE=3 SV=4 CANONICAL=E1BQ07-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T1G9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1G9/entry", "sequence": { "sequence": "MYRAAVFDTGSRGLKPWMIALLIVLLLTVVAVAIGLLVHFLVSDQKMEYYHATFKISDLRGNGNSRQNSPYRFMELREISENLVDETFIDSALNKHYIKNQVVKLTPEEDGMTVDVIMVFQFPSAESSAVRNRKIRSILDEKIRNTRALSINTSSVEVNGCGKRVVPLVSNRIMSGEIAGKAAWPWQASLQHNKIHQCGATLISNTWLVTAAHCFKNKENPHQWTVSFGTKINPPLMKRNIKRIIVHERYSSPAREYDIAVVQFSPRVSFTDDIRRICLPEASASFQPNSTVYITGFGALFYGGESQNDLREARLKIISDDVCKQPHVYGSDIKFGMMCAGYLEGIYDACRGDSGGPLVGKDFKDTWYLIGIVSWGDNCGQRNKPGVYTKVTYYRNWIASKTGL", "length": 404, "header": "tr|A0AAA9T1G9-1|E1BQ07_BOVIN Computationally mapped isoform of Transmembrane protease serine OS=Bos taurus OX=9913 GN=TMPRSS11A PE=3 SV=1 CANONICAL=E1BQ07-1" }, "locus": { "chromosome": "6", "start_pos": 83676771, "end_pos": 83614948, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090542.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090542.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090423.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090423.1" } ] } }, { "isoform_ac": "E1BQ07-1", "url": "https://www.uniprot.org/uniprotkb/E1BQ07/entry", "sequence": { "sequence": "IMYRAAVFDTGSRGLKPWMIALLIVLLLTVVAVAIGLLVHFLVSDQKMEYYHATFKISDLRGNGNSRQNSPYRFMELREISENLVDETFIDSALNKHYIKNQVVKLTPEEDGMTVDVIMVFQFPSAESSAVRNRKIRSILDEKIRNTRALSINTSSVEVNAMSSSTGKLTVQACCGKRVVPLVSNRIMSGEIAGKAAWPWQASLQHNKIHQCGATLISNTWLVTAAHCFKNKENPHQWTVSFGTKINPPLMKRNIKRIIVHERYSSPAREYDIAVVQFSPRVSFTDDIRRICLPEASASFQPNSTVYITGFGALFYGGESQNDLREARLKIISDDVCKQPHVYGSDIKFGMMCAGYLEGIYDACRGDSGGPLVGKDFKDTWYLIGIVSWGDNCGQRNKPGVYTKVTYYRNWIASKTGL", "length": 418, "header": "tr|E1BQ07-1|E1BQ07_BOVIN Isoform 1 of Transmembrane protease serine OS=Bos taurus OX=9913 GN=TMPRSS11A PE=3 SV=4 CANONICAL=E1BQ07-1" }, "locus": { "chromosome": "6", "start_pos": 83676774, "end_pos": 83614948, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027052.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027052.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027052.7", "url": "https://www.ensembl.org/id/ENSBTAP00000027052.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "E1BQ07", "url": "https://www.uniprot.org/uniprotkb/E1BQ07" } ], "pmid": "" }, { "name": "serine-type peptidase activity", "id": "GO:0008236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008236", "evidence": [ { "database": "UniProtKB", "id": "E1BQ07", "url": "https://www.uniprot.org/uniprotkb/E1BQ07" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "E1BQ07", "url": "https://www.uniprot.org/uniprotkb/E1BQ07" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BQ07", "url": "https://www.uniprot.org/uniprotkb/E1BQ07" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "E1BQ07", "url": "https://www.uniprot.org/uniprotkb/E1BQ07" } ], "pmid": "" }, { "name": "protein processing", "id": "GO:0016485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016485", "evidence": [ { "database": "UniProtKB", "id": "E1BQ07", "url": "https://www.uniprot.org/uniprotkb/E1BQ07" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BQ07-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 418, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BQ07-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BQ07" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BQ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ07" }, { "id": "PS50240", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50240" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S1", "eco_id": "ECO_0000259", "start_pos": 187, "end_pos": 417, "start_aa": "Ile", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BQ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ07" }, { "id": "PS50024", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50024" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SEA", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 164, "start_aa": "Lys", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 153, "end_pos": 155 }, { "start_pos": 303, "end_pos": 305 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MFL5-1", "uniprot_ac": "F1MFL5", "uniprot_id": "F1MFL5_BOVIN", "mass": { "chemical_mass": 20835.0, "monoisotopic_mass": 20835.0 }, "refseq": { "ac": "NP_001178301", "name": "histone deacetylase complex subunit SAP30L", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178301" }, "gene_names": [ { "name": "SAP30L", "type": "recommended", "evidence": [ { "id": "F1MFL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ] }, { "name": "SAP30L", "type": "synonym", "evidence": [ { "id": "NP_001178301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178301" } ] } ], "protein_names": [ { "name": "Histone deacetylase complex subunit SAP30L", "type": "recommended", "evidence": [ { "id": "F1MFL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFL5/entry#names_and_taxonomy" } ] }, { "name": "Sin3 corepressor complex subunit SAP30L", "type": "synonym", "evidence": [ { "id": "F1MFL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFL5/entry#names_and_taxonomy" } ] }, { "name": "Sin3-associated protein p30-like", "type": "synonym", "evidence": [ { "id": "F1MFL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFL5/entry#names_and_taxonomy" } ] }, { "name": "histone deacetylase complex subunit SAP30L", "type": "synonym", "evidence": [ { "id": "NP_001178301", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178301" } ] } ], "function": [ { "annotation": "Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T2Z1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Z1#function" }, { "database": "UniProtKB", "id": "ARBA00045340", "url": "https://www.uniprot.org/uniprotkb/ARBA00045340#function" }, { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SAP30L", "url": "https://www.uniprot.org/uniprotkb/F1MFL5", "locus": { "chromosome": "7", "start_pos": 65730940, "end_pos": 65722338, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004000", "url": "https://www.ensembl.org/id/ENSBTAG00000004000" } ] } } ], "crossref": [ { "id": "F1MFL5", "url": "https://alphafold.ebi.ac.uk/entry/F1MFL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004000", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004000", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533462", "url": "https://www.ncbi.nlm.nih.gov/gene/533462", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR024145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025718", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025718", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533462", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533462", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SDQICCL", "url": "https://omabrowser.org/oma/group/SDQICCL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MFL5", "url": "https://www.orthodb.org/?gene=F1MFL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13286", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13286", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13286:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13286:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13866", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13866", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13867", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13867", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3214815", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214815", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001178301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178301", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T2Z1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Z1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2Z1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Z1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFL5-1", "url": "https://www.uniprot.org/uniprotkb/F1MFL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNGFSTEEDSREGPPAAPAAAPGYGQSCCLIEDGERCVRPAGNASFSKRVQKSISQKKLKLDIDKSVRHLYICDFHKNFIQSVRNKRKRKTSDDGGDSPEHDTDIPEVDLFQLQVNTLRRYKRHYKLQTRPGFNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNKSRLDQKSESGKQLE", "length": 182, "header": "tr|F1MFL5-1|F1MFL5_BOVIN Isoform 1 of Histone deacetylase complex subunit SAP30L OS=Bos taurus OX=9913 GN=SAP30L PE=3 SV=2 CANONICAL=F1MFL5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2Z1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2Z1/entry", "sequence": { "sequence": "MNGFSTEEDSREGPPAAPAAAPGYGQSCCLIEDGERCVRPAGNASFSKRVQKSISQKKLKLDIDKSVDLFQLQVNTLRRYKRHYKLQTRPGFNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNKSRLDQKSESGKQLE", "length": 141, "header": "tr|A0AAA9T2Z1-1|F1MFL5_BOVIN Computationally mapped isoform of Histone deacetylase complex subunit SAP30L OS=Bos taurus OX=9913 GN=SAP30L PE=3 SV=1 CANONICAL=F1MFL5-1" }, "locus": { "chromosome": "7", "start_pos": 65730711, "end_pos": 65722652, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118757.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118757.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090835.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090835.1" } ] } }, { "isoform_ac": "F1MFL5-1", "url": "https://www.uniprot.org/uniprotkb/F1MFL5/entry", "sequence": { "sequence": "MNGFSTEEDSREGPPAAPAAAPGYGQSCCLIEDGERCVRPAGNASFSKRVQKSISQKKLKLDIDKSVRHLYICDFHKNFIQSVRNKRKRKTSDDGGDSPEHDTDIPEVDLFQLQVNTLRRYKRHYKLQTRPGFNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNKSRLDQKSESGKQLE", "length": 182, "header": "tr|F1MFL5-1|F1MFL5_BOVIN Isoform 1 of Histone deacetylase complex subunit SAP30L OS=Bos taurus OX=9913 GN=SAP30L PE=3 SV=2 CANONICAL=F1MFL5-1" }, "locus": { "chromosome": "7", "start_pos": 65730711, "end_pos": 65722652, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005222.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005222.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005222.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005222.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:533462", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533462", "resource": "KEGG Pathway" }, { "id": "R-BTA-3214815", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214815", "resource": "Reactome", "description": "HDACs deacetylate histones" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ABA7-1", "protein_name": "Histone deacetylase complex subunit SAP30L", "gene_name": "SAP30L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNGFSTEEDSREGPPAAPAAAPGYGQSCCLIEDGERCVRPAGNASFSKRVQKSISQKKLKLDIDKSVRHLYICDFHKNFIQSVRNKRKRKTSDDGGDSPEHDTDIPEVDLFQLQVNTLRRYKRHYKLQTRPGFNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNKSRLDQKSEGGKQLE", "length": 182 }, "evidence": [ { "id": "F1MFL5", "url": "https://omabrowser.org/oma/group/F1MFL5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZJK3-1", "protein_name": "Histone deacetylase complex subunit SAP30L", "gene_name": "Sap30l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNGFSTEEDSREGPPAAPAAAPGYGQSCCLIADGERCVRPAGNASFSKRVQKSISQKKLKLDIDKSVRHLYICDFHKNFIQSVRNKRKRKTSDDGGDSPEHDADIPEVDLFQLQVNTLRRYKRHYKLQTRPGFNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNRSRLDQKPEGSKQLE", "length": 182 }, "evidence": [ { "id": "F1MFL5", "url": "https://omabrowser.org/oma/group/F1MFL5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5SQF8-1", "protein_name": "Histone deacetylase complex subunit SAP30L", "gene_name": "Sap30l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNGFSTEEDSREGPPAAPAAAPGYGQSCCLIADGERCVRPAGNASFSKRVQKSISQKKLKLDIDKSVRHLYICDFHKNFIQSVRNKRKRKASDDGGDSPEHDADIPEVDLFQLQVNTLRRYKRHYKLQTRPGFNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNRSRLDQKSEGSKQLE", "length": 182 }, "evidence": [ { "id": "F1MFL5", "url": "https://omabrowser.org/oma/group/F1MFL5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6NYV5-1", "protein_name": "Histone deacetylase complex subunit SAP30L", "gene_name": "sap30l", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNGFSTEEDSHDGPPAPPFFGQSCCLIEDAERCGRPAGNASFSKRIQKSISQRKLKLDIDKSVRHLYICDFHKNFIQSVRNKRKRKTSDDGGESPDHEVEVPEVDLFQLQVNTLRRYKRHYKIQTRPGLNKAQLAETVSRHFRNIPVNEKETLTYFIYMVKSSKSRLDQKSDSSKQVE", "length": 178 }, "evidence": [ { "id": "F1MFL5", "url": "https://omabrowser.org/oma/group/F1MFL5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9HAJ7-1", "protein_name": "Histone deacetylase complex subunit SAP30L", "gene_name": "SAP30L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNGFSTEEDSREGPPAAPAAAAPGYGQSCCLIEDGERCVRPAGNASFSKRVQKSISQKKLKLDIDKSVRHLYICDFHKNFIQSVRNKRKRKTSDDGGDSPEHDTDIPEVDLFQLQVNTLRRYKRHYKLQTRPGFNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNKSRLDQKSEGGKQLE", "length": 183 }, "evidence": [ { "id": "F1MFL5", "url": "https://omabrowser.org/oma/group/F1MFL5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VXB3-1", "protein_name": "Histone deacetylase complex subunit SAP30 homolog", "gene_name": "Sap30", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNNGFSTGEEDSRGHTDQTCCLIDDMERCRNQAGYASYSKRIQKTVAQKRLKLSSDPAAQHIYICDHHKERIQSVRTKRRRKDSEDDSNETDTDLHEFPDLYQLGVSTLRRYKRHFKVQTRQGMKRAQLADTIMKHFKTIPIKEKEIITFFVYMVKMGSNKLDQKNGLGNDTT", "length": 173 }, "evidence": [ { "id": "F1MFL5", "url": "https://omabrowser.org/oma/group/F1MFL5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ], "pmid": "" }, { "name": "phosphatidylinositol-5-phosphate binding", "id": "GO:0010314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010314", "evidence": [ { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ], "pmid": "" }, { "name": "nucleosome binding", "id": "GO:0031491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031491", "evidence": [ { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ], "pmid": "" }, { "name": "non-sequence-specific DNA binding, bending", "id": "GO:0044378", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044378", "evidence": [ { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ], "pmid": "" }, { "name": "histone deacetylase complex", "id": "GO:0000118", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000118", "evidence": [ { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1MFL5", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 43, "end_pos": 45, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MFL5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 182, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MFL5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MFL5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" }, { "id": "PF13867", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13867" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Histone deacetylase complex subunit SAP30 Sin3 binding", "eco_id": "ECO_0000259", "start_pos": 113, "end_pos": 165, "start_aa": "Leu", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MFL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFL5" }, { "id": "PF13866", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13866" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Histone deacetylase complex subunit SAP30 zinc-finger", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 94, "start_aa": "Gly", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 167, "end_pos": 169 }, { "start_pos": 43, "end_pos": 45 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MFA7-1", "uniprot_ac": "F1MFA7", "uniprot_id": "F1MFA7_BOVIN", "mass": { "chemical_mass": 104122.0, "monoisotopic_mass": 104122.0 }, "refseq": { "ac": "XP_024841885", "name": "coiled-coil domain-containing protein 186 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841885" }, "gene_names": [ { "name": "CCDC186", "type": "recommended", "evidence": [ { "id": "F1MFA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFA7" } ] }, { "name": "CCDC186", "type": "synonym", "evidence": [ { "id": "XP_024841885", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841885" } ] } ], "protein_names": [ { "name": "Coiled-coil domain containing 186", "type": "synonym", "evidence": [ { "id": "F1MFA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFA7/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain-containing protein 186 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_024841885", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841885" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFA7", "url": "https://www.uniprot.org/uniprotkb/F1MFA7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCDC186", "url": "https://www.uniprot.org/uniprotkb/F1MFA7", "locus": { "chromosome": "26", "start_pos": 34590596, "end_pos": 34634165, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020233", "url": "https://www.ensembl.org/id/ENSBTAG00000020233" } ] } } ], "crossref": [ { "id": "F1MFA7", "url": "https://alphafold.ebi.ac.uk/entry/F1MFA7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020233", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020233", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535781", "url": "https://www.ncbi.nlm.nih.gov/gene/535781", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR038830", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038830", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535781", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535781", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TLSNGMC", "url": "https://omabrowser.org/oma/group/TLSNGMC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR18911", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18911", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18911:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18911:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27942", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27942", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024841885", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841885", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T5L2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5L2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFA7", "url": "https://www.uniprot.org/uniprotkb/F1MFA7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFA7-1", "url": "https://www.uniprot.org/uniprotkb/F1MFA7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSETEHIASISSDQNIEKTSETKEGSCNSSSGDESSSLENESKLLSLNLDKTLCQPNEHNNQTETQENYIPDHGGGKDSCAKTDTGPESSEQIASFPGGDFTKQVLKTSEAEQTVTQILAELRSSTFTAAGNQKTYSESPYDTDCTKKLISKIKNVSTSEDLLEEIESELLSTEFAKEHRVPNGMNKGENALIMFEKCVQDKYLQQEHTIKKLIKENKKHQELILDICSEKDNLREELKKRTETEKQHMNTIKQLETRIEELNKEVQASKDKVLAQDIAAKNAIQQLHKEMAHRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKEMLEKKLRDANKECEKNTNKIKQLSQEKGRLHQLYETKEGEATRLIREIDKLKEDINSHIIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKIADQIQEQHQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTEKLTSKNAQLQSESNSLQSQFDKLSCSESQLQSQCEHMKQTNMNLESRLLKEEELRKEEVQALQAELTCRQTEVKALSTQVEELKDELVTQRRKHASSVKDLTKQLQQARRKLDQVENGSCDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPEVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTNVLFYRIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADTGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKT", "length": 904, "header": "tr|F1MFA7-1|F1MFA7_BOVIN Isoform 1 of Coiled-coil domain containing 186 OS=Bos taurus OX=9913 GN=CCDC186 PE=4 SV=4 CANONICAL=F1MFA7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5L2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5L2/entry", "sequence": { "sequence": "MSETEHIASISSDQNIEKTSETKEGSCNSSSGDESSSLENESKLLSLNLDKTLCQPNEHNNQTETQENYIPDHGGGKDSCAKTDTGPESSEQIASFPGGDFTKQVLKTSEAEQTVTQILAELRSSTFTAAGNQKTYSESPYDTDCTKKLISKIKNVSTSEDLLEEIESELLSTEFAKEHRVPNGMNKGENALIMFEKCVQDKYLQQEHTIKKLIKENKKHQELILDICSEKDNLREELKKRTETEKQHMNTIKQLETRIEELNKEVQASKDKVLAQDIAAKNAIQQLHKEMAHRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKEMLEKKLRDANKECEKNTNKIKQLSQEKGRLHQLYETKEGEATRLIREIDKLKEDINSHIIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKIADQIQEQHQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTEKLTSKNAQLQSESNSLQSQFDKLSCSESQLQSQCEHMKQTNMNLESRLLKEEELRKEEVQALQAELTCRQTEVKALSTQVEELKDELVTQRRKHASSVKDLTKQLQQARRKLDQVENGSCDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPEVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADTGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKT", "length": 899, "header": "tr|A0AAA9T5L2-1|F1MFA7_BOVIN Computationally mapped isoform of Coiled-coil domain containing 186 OS=Bos taurus OX=9913 GN=CCDC186 PE=4 SV=1 CANONICAL=F1MFA7-1" }, "locus": { "chromosome": "26", "start_pos": 34624779, "end_pos": 34591600, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132865.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132865.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091857.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091857.1" } ] } }, { "isoform_ac": "F1MFA7-1", "url": "https://www.uniprot.org/uniprotkb/F1MFA7/entry", "sequence": { "sequence": "MSETEHIASISSDQNIEKTSETKEGSCNSSSGDESSSLENESKLLSLNLDKTLCQPNEHNNQTETQENYIPDHGGGKDSCAKTDTGPESSEQIASFPGGDFTKQVLKTSEAEQTVTQILAELRSSTFTAAGNQKTYSESPYDTDCTKKLISKIKNVSTSEDLLEEIESELLSTEFAKEHRVPNGMNKGENALIMFEKCVQDKYLQQEHTIKKLIKENKKHQELILDICSEKDNLREELKKRTETEKQHMNTIKQLETRIEELNKEVQASKDKVLAQDIAAKNAIQQLHKEMAHRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKEMLEKKLRDANKECEKNTNKIKQLSQEKGRLHQLYETKEGEATRLIREIDKLKEDINSHIIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKIADQIQEQHQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTEKLTSKNAQLQSESNSLQSQFDKLSCSESQLQSQCEHMKQTNMNLESRLLKEEELRKEEVQALQAELTCRQTEVKALSTQVEELKDELVTQRRKHASSVKDLTKQLQQARRKLDQVENGSCDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPEVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTNVLFYRIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADTGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKT", "length": 904, "header": "tr|F1MFA7-1|F1MFA7_BOVIN Isoform 1 of Coiled-coil domain containing 186 OS=Bos taurus OX=9913 GN=CCDC186 PE=4 SV=4 CANONICAL=F1MFA7-1" }, "locus": { "chromosome": "26", "start_pos": 34624779, "end_pos": 34591600, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031607.6", "url": "https://www.ensembl.org/id/ENSBTAT00000031607.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031558.6", "url": "https://www.ensembl.org/id/ENSBTAP00000031558.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:535781", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535781", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZN75-1", "protein_name": "Coiled-coil domain containing 186", "gene_name": "CCDC186", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MMEEYSPGMQSTLEPVGLSEEASYHSSDSKKSCETSGMKDCSSISCTGDDVGVLEAEPRLLSSDRDSAAADMSGGGGLTERQEQQCAPLDHSEGQDCGANTCSEIRVEGSMETGCLSKEEFGQDPKTNQTEQSLIELLQELREESDLVRKSGDKIYSESPYDTDCTKKLISTIQQTSSQEDLLKEIESELLSTDFSKECKCPNGVRKGEHALAVFDKCVQDKYLQQEQTIKKLIKENKKHQELILEICSEKDNLKDELKKRSETEKQHLNIIKQLEARIEELNKEVKANKDKLVAQDAAAKNAIQQLHKEMAFRMEQANKKCEEARHEKETMVMKYVRGEKESLDLRKEKEILERRVRDANKEIEKHTNKIKQLSQEKGRLHQLYETKDAEATRLNKEIEKLKEEINSHIIKVKWAQNKLKTEMDSHKESKERLKDATTKLTQAKEEADQIRKNCQEMIKTYQESEEIKSNELDAKFKVTKGELEKQMQEKSDQLEVPHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKTEIQSLLDRVKTVDRLQDQHQRDEQDISALKEEVDGLNSLIADLQKDIEGSRKRESELLIFTEKLTSKNAQLQSENNSLQSQLDKLSYSERELQNQLECVQQAKDDLATKLQKEEDQRKLEVEMLQAQLASEQKELTALKTHVDELKDELTTQKRKHAANLKDLSKQLQLARRKLDQIENGNYDKEVSSMGSRSSSSGSLNARSGNEDRSPENTGSSVAVDSFPEVDKSVLVERILRLQKAHARKNEKMEFMEDHIKHLVEEIRKKTKIIQSYILREEAGALSSEASDFNKVHLSRRGGIMASLYTSHPADSGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHKHELEQKIKQT", "length": 919 }, "evidence": [ { "id": "F1MFA7", "url": "https://omabrowser.org/oma/group/F1MFA7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q7Z3E2-1", "protein_name": "Coiled-coil domain-containing protein 186", "gene_name": "CCDC186", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSETDHIASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDHGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKT", "length": 898 }, "evidence": [ { "id": "F1MFA7", "url": "https://omabrowser.org/oma/group/F1MFA7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C9S4-1", "protein_name": "Coiled-coil domain-containing protein 186", "gene_name": "Ccdc186", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKIRSRFEEMQSELVPVSMSETEHIASISSDATTEKTSELRDDSCISVSGDESSRLETGAELLSLDSDRILCQTNEHCSQIEVQESHIPDCGSGENSCANTDTCPEDSGQIDDFPGGDFTEQVSKTKEPEQTVTQILAELKSSAPAEAANPKTASASLYDTDCTRKLISEMKTVSASDDLLGEIESELLSAEFAEGHQVPNGLNKGEQALALFEKCVHSRYLQQELTVKQLIKENKNHQELILNICSEKDSLREELRKRTETEKQHMNTIKQLELRIEELNKEIKASKDQLVAQDVTAKNAIQQIHKEMAQRMDQANKKCEEARQEKEAMVMKYVRGEKEALDLRKEKETLERKLRDASKELEKNTNKIKQLSQEKGRLQQLYESKEGETTRLIREIEKLKEEMNSQVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEAEQIRQNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKAKCLEDERLRTEDELSKYREIINRQKSEIQNLLDKVKITDQLHEQLQSGKQEIEHLKEEMESLNSLINDLQKDIEGSRKRESELLLFTEKLTSKNAQLQSESSALQSQVDNLSCTESQLQSQCQQMGQANRNLESKLLKEEELRKEEVQTLQAELSAAQTEVKALSTQVEELKDELVTQRRKHASNVKDLSKQLQQARRKLEQTENGNHDKDISSMGSRSSSSGSLNARISAEDRSPENTSSSVAVDNFPEVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYVLREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADSGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKA", "length": 917 }, "evidence": [ { "id": "F1MFA7", "url": "https://omabrowser.org/oma/group/F1MFA7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "F1MFA7", "url": "https://www.uniprot.org/uniprotkb/F1MFA7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "F1MFA7", "url": "https://www.uniprot.org/uniprotkb/F1MFA7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "vesicle cytoskeletal trafficking", "id": "GO:0099518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099518", "evidence": [ { "database": "UniProtKB", "id": "F1MFA7", "url": "https://www.uniprot.org/uniprotkb/F1MFA7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" }, { "start_pos": 711, "end_pos": 713, "annotation": "n_glycosylation_sequon" }, { "start_pos": 873, "end_pos": 875, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MFA7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 904, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MFA7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MFA7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 155, "end_pos": 157 }, { "start_pos": 28, "end_pos": 30 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 61, "end_pos": 63 }, { "start_pos": 711, "end_pos": 713 }, { "start_pos": 873, "end_pos": 875 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MIX0-1", "uniprot_ac": "F1MIX0", "uniprot_id": "F1MIX0_BOVIN", "mass": { "chemical_mass": 47830.0, "monoisotopic_mass": 47830.0 }, "refseq": {}, "gene_names": [ { "name": "ABRAXAS2", "type": "recommended", "evidence": [ { "id": "F1MIX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIX0" } ] } ], "protein_names": [ { "name": "Abraxas 2, BRISC complex subunit", "type": "synonym", "evidence": [ { "id": "F1MIX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIX0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MIX0", "url": "https://www.uniprot.org/uniprotkb/F1MIX0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ABRAXAS2", "url": "https://www.uniprot.org/uniprotkb/F1MIX0", "locus": { "chromosome": "26", "start_pos": 44410582, "end_pos": 44381561, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023840", "url": "https://www.ensembl.org/id/ENSBTAG00000023840" } ] } } ], "crossref": [ { "id": "F1MIX0", "url": "https://alphafold.ebi.ac.uk/entry/F1MIX0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023840", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023840", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23524", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23524", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR023238", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023238", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023240", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023240", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MIX0", "url": "https://www.orthodb.org/?gene=F1MIX0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31728", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31728", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31728:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31728:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21125", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21125", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5689901", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689901", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T5V8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5V8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5V8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5V8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGM3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TGM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIX0", "url": "https://www.uniprot.org/uniprotkb/F1MIX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIX0-1", "url": "https://www.uniprot.org/uniprotkb/F1MIX0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMGELELSIMAASISGYTFSAVCFHSANSNADHEGFLLGEVRQEETFSISDSQISSTEFLQVIEIHNHQPCSKLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVIHKQLTRILGVPDLVFLLFSFISTANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGADFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQRKNEKEQERRLQQAMVSRQMPSESVDPTFSPRMPYPGFTAEGRSTLGDTEASDPPPPYSDLHPNNQESTLSHSRMESSVFMPRPQAVGSSSYASTSAGLKYPGSGADAPPSHRAAGDSAEESDDSDYENLIDPTEPPNSEYSRSRDSRPMTHPDGGSRNTQTSQI", "length": 424, "header": "tr|F1MIX0-1|F1MIX0_BOVIN Isoform 1 of Abraxas 2, BRISC complex subunit OS=Bos taurus OX=9913 GN=ABRAXAS2 PE=3 SV=3 CANONICAL=F1MIX0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5V8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5V8/entry", "sequence": { "sequence": "MQGAWPVSGCLEYRRREEIHNHQPCSKLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVIHKQLTRILGVPDLVFLLFSFISTANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGADFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQRKNEKEQERRLQQAMVSRQMPSESVDPTFSPRMPYPGFTAEGRSTLGDTEASDPPPPYSDLHPNNQESTLSHSRMESSVFMPRPQAVGSSSYASTSAGLKYPGSGADAPPSHRAAGDSAEESDDSDYENLIDPTEPPNSEYSRSRDSRPMTHPDGGSRNTQTSQI", "length": 378, "header": "tr|A0AAA9T5V8-1|F1MIX0_BOVIN Computationally mapped isoform of Abraxas 2, BRISC complex subunit OS=Bos taurus OX=9913 GN=ABRAXAS2 PE=3 SV=1 CANONICAL=F1MIX0-1" }, "locus": { "chromosome": "26", "start_pos": 44408893, "end_pos": 44386879, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130703.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130703.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094145.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094145.1" } ] } }, { "isoform_ac": "A0AAA9TGM3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGM3/entry", "sequence": { "sequence": "MQERALAWHAHKSSISEIHNHQPCSKLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVIHKQLTRILGVPDLVFLLFSFISTANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGADFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQRKNEKEQERRLQQAMVSRQMPSESVDPTFSPRMPYPGFTAEGRSTLGDTEASDPPPPYSDLHPNNQESTLSHSRMESSVFMPRPQAVGSSSYASTSAGLKYPGSGADAPPSHRAAGDSAEESDDSDYENLIDPTEPPNSEYSRSRDSRPMTHPDGGSRNTQTSQI", "length": 377, "header": "tr|A0AAA9TGM3-1|F1MIX0_BOVIN Computationally mapped isoform of Abraxas 2, BRISC complex subunit OS=Bos taurus OX=9913 GN=ABRAXAS2 PE=3 SV=1 CANONICAL=F1MIX0-1" }, "locus": { "chromosome": "26", "start_pos": 44408893, "end_pos": 44387346, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090936.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090936.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097339.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097339.1" } ] } }, { "isoform_ac": "F1MIX0-1", "url": "https://www.uniprot.org/uniprotkb/F1MIX0/entry", "sequence": { "sequence": "MMGELELSIMAASISGYTFSAVCFHSANSNADHEGFLLGEVRQEETFSISDSQISSTEFLQVIEIHNHQPCSKLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVIHKQLTRILGVPDLVFLLFSFISTANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGADFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQRKNEKEQERRLQQAMVSRQMPSESVDPTFSPRMPYPGFTAEGRSTLGDTEASDPPPPYSDLHPNNQESTLSHSRMESSVFMPRPQAVGSSSYASTSAGLKYPGSGADAPPSHRAAGDSAEESDDSDYENLIDPTEPPNSEYSRSRDSRPMTHPDGGSRNTQTSQI", "length": 424, "header": "tr|F1MIX0-1|F1MIX0_BOVIN Isoform 1 of Abraxas 2, BRISC complex subunit OS=Bos taurus OX=9913 GN=ABRAXAS2 PE=3 SV=3 CANONICAL=F1MIX0-1" }, "locus": { "chromosome": "26", "start_pos": 44408893, "end_pos": 44381760, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032734.6", "url": "https://www.ensembl.org/id/ENSBTAT00000032734.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032663.5", "url": "https://www.ensembl.org/id/ENSBTAP00000032663.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5689901", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689901", "resource": "Reactome", "description": "Metalloprotease DUBs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "response to ischemia", "id": "GO:0002931", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002931", "evidence": [ { "database": "UniProtKB", "id": "F1MIX0", "url": "https://www.uniprot.org/uniprotkb/F1MIX0" } ], "pmid": "" }, { "name": "attachment of spindle microtubules to kinetochore", "id": "GO:0008608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008608", "evidence": [ { "database": "UniProtKB", "id": "F1MIX0", "url": "https://www.uniprot.org/uniprotkb/F1MIX0" } ], "pmid": "" }, { "name": "cell 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"https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "F1MH47", "url": "https://www.uniprot.org/uniprotkb/F1MH47" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MH47-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 232, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MH47-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MH47" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MH47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH47" }, { "id": "PF15913", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15913" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "R-spondin Fu-CRD", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 135, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 34, "end_pos": 36 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGS3-1", "uniprot_ac": "F1MGS3", "uniprot_id": "F1MGS3_BOVIN", "mass": { "chemical_mass": 66222.0, "monoisotopic_mass": 66222.0 }, "refseq": { "ac": "NP_001192452", "name": "interactor of HORMAD1 protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192452" }, "gene_names": [ { "name": "IHO1", "type": "recommended", "evidence": [ { "id": "F1MGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGS3" } ] }, { "name": "CCDC36", "type": "synonym", "evidence": [ { "id": "NP_001192452", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192452" } ] }, { "name": "IHO1", "type": "synonym", "evidence": [ { "id": "NP_001192452", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192452" } ] } ], "protein_names": [ { "name": "Interactor of HORMAD1 1", "type": "synonym", "evidence": [ { "id": "F1MGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGS3/entry#names_and_taxonomy" } ] }, { "name": "coiled-coil domain containing 36", "type": "synonym", "evidence": [ { "id": "NP_001192452", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192452" } ] }, { "name": "interactor of HORMAD1 protein 1", "type": "synonym", "evidence": [ { "id": "NP_001192452", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192452" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MGS3", "url": "https://www.uniprot.org/uniprotkb/F1MGS3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IHO1", "url": "https://www.uniprot.org/uniprotkb/F1MGS3", "locus": { "chromosome": "22", "start_pos": 50813643, "end_pos": 50840886, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009371", "url": "https://www.ensembl.org/id/ENSBTAG00000009371" } ] } } ], "crossref": [ { "id": "F1MGS3", "url": "https://alphafold.ebi.ac.uk/entry/F1MGS3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009371", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009371", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "520504", "url": "https://www.ncbi.nlm.nih.gov/gene/520504", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031529", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031529", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:520504", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520504", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PGHVKDS", "url": "https://omabrowser.org/oma/group/PGHVKDS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGS3", "url": "https://www.orthodb.org/?gene=F1MGS3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR35662", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35662", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR35662:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35662:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15771", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15771", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192452", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T6D0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6D0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6D0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6D0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGS3", "url": "https://www.uniprot.org/uniprotkb/F1MGS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGS3-1", "url": "https://www.uniprot.org/uniprotkb/F1MGS3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNFNVWNIKDMFSIPSGSGATKSSNWNNNQTDYSSLSDSQFLFGSQFCPEGSQTLSTPVDSEVHLRHPKQSQQNSLDSEPSIFTKYQTKPQLLGGDPKDGGLFPLPLSLGKPKGLLEQFEEKKKSAKDKCDSETLYNFISHIKESIHKLQTSVEESEEHLSSRSQSILDSLETVAKTWQETAKAQSGLMLEIVQDKGNVDQAILELQKRLEARQAEFTEMKSDLKHLEVLVIQQSKDFQQLCEHLGQLNMPSVLAELKRLTSIALTPKHVKDSASQTSPPLAQSLSFPRQDKYTSEKPVTWQAQALPAACSLSVGSPRPREFAVWGEGSKRDALQEEAVQPAVGTGKRNRQIKGRAVKTNCQNSVTKTGSENCGSAILGHKVPKDRDPVFQGDSQLISRGYKDLNNSATSIKNTSQKWQAKGAFSCHPCEQRLVTEQKGVTVERGKKDKQQPRKAPRRRSLRRKQEQMPSKTCVSNSKYPRPPVSSPQSSPWGQQETLAQPLQLWGPRSPTNLVCSAQGGTVMPSKTTRAEQGNLVQCSGHSSQDNSLLFPSFQGDHKMSWFSDLNDLNPRAESLQSQESGKNILYDLGFDSSDDGF", "length": 597, "header": "tr|F1MGS3-1|F1MGS3_BOVIN Isoform 1 of Interactor of HORMAD1 1 OS=Bos taurus OX=9913 GN=IHO1 PE=4 SV=2 CANONICAL=F1MGS3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T6D0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6D0/entry", "sequence": { "sequence": "MNFNVWNIKDMFSIPSGSGATKSSNWNNNQTDYSSLSDSQFLFGSQFCPEGSQTLSTPVDSEVHLRHPKQSQQNSLDSEPSIFTKYQTKPQLLGGDPKDGGLFPLPLSLGKPKGLLEQFEEKKKSAKDKCDSYRHQWKSLRNISVPEVSLFWILWKLWPRHVSVSCLRYQQGALVSSDRELADPSQVSASGEVPQSVSDERMGT", "length": 204, "header": "tr|A0AAA9T6D0-1|F1MGS3_BOVIN Computationally mapped isoform of Interactor of HORMAD1 1 OS=Bos taurus OX=9913 GN=IHO1 PE=4 SV=1 CANONICAL=F1MGS3-1" }, "locus": { "chromosome": "22", "start_pos": 50836271, "end_pos": 50820621, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117735.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117735.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092287.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092287.1" } ] } }, { "isoform_ac": "F1MGS3-1", "url": "https://www.uniprot.org/uniprotkb/F1MGS3/entry", "sequence": { "sequence": "MNFNVWNIKDMFSIPSGSGATKSSNWNNNQTDYSSLSDSQFLFGSQFCPEGSQTLSTPVDSEVHLRHPKQSQQNSLDSEPSIFTKYQTKPQLLGGDPKDGGLFPLPLSLGKPKGLLEQFEEKKKSAKDKCDSETLYNFISHIKESIHKLQTSVEESEEHLSSRSQSILDSLETVAKTWQETAKAQSGLMLEIVQDKGNVDQAILELQKRLEARQAEFTEMKSDLKHLEVLVIQQSKDFQQLCEHLGQLNMPSVLAELKRLTSIALTPKHVKDSASQTSPPLAQSLSFPRQDKYTSEKPVTWQAQALPAACSLSVGSPRPREFAVWGEGSKRDALQEEAVQPAVGTGKRNRQIKGRAVKTNCQNSVTKTGSENCGSAILGHKVPKDRDPVFQGDSQLISRGYKDLNNSATSIKNTSQKWQAKGAFSCHPCEQRLVTEQKGVTVERGKKDKQQPRKAPRRRSLRRKQEQMPSKTCVSNSKYPRPPVSSPQSSPWGQQETLAQPLQLWGPRSPTNLVCSAQGGTVMPSKTTRAEQGNLVQCSGHSSQDNSLLFPSFQGDHKMSWFSDLNDLNPRAESLQSQESGKNILYDLGFDSSDDGF", "length": 597, "header": "tr|F1MGS3-1|F1MGS3_BOVIN Isoform 1 of Interactor of HORMAD1 1 OS=Bos taurus OX=9913 GN=IHO1 PE=4 SV=2 CANONICAL=F1MGS3-1" }, "locus": { "chromosome": "22", "start_pos": 50836271, "end_pos": 50813756, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012334.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012334.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012334.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012334.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:520504", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520504", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7JHK8-1", "protein_name": "Interactor of HORMAD1 protein 1", "gene_name": "Iho1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNFNVWNIKEMLSIPSSSGITKPSNWNSNQTDCSSPSDSQFLFGSQFCPENSESLSASLDIGAYSRHPKQTQQNSVDNEPSIFTKYQTKPQLFGGDTKDEGLFSLPLPVGKSKGLLKQFEEKKRRATDKCDSEMLYNFVSHFQEVIHKLQTSVEKSEENLSSRSQSILDSLETVAKTFQESAQVQRDLIFDAMRDKGNMEQAILELQRSSETRQAEFMEMKSNLKNLEVLVTQQSKDFQQLCEKLGQLNVPGVLEELKKLSAPRLVGHLKDSTSQTSPALAQSLHFTGQEKCTSEAQVSPTGSSQRPREFGVWDEGAESGVFQKAALLTDEPHRGNEHVKNNAMQTYYKNWVITTRSLTNHCASLPSQKADHDEDLVADEASQLDLNKFESRVKNACPQIEAQNMCSSDLFEQSATEQKDRTRGKERKGKKQHPRKSQRGRLLARKQEQTPRKACAFVSRHCRTQTSVSSPQGSIICWRAPRIAMKSARPILGRIVRTNKTARATPGSIQQSTQCSSPVCESLSSSSQEDQQINWFSDLSLENPEPPLCKKGGKNLLCDPDFDSSDDNL", "length": 569 }, "evidence": [ { "id": "F1MGS3", "url": "https://omabrowser.org/oma/group/F1MGS3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "M0R8J7-1", "protein_name": "Interactor of HORMAD1 1", "gene_name": "Iho1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNFNVWNVKEMLSIPSGSGLTKPSNWNSNQTDCSSLSDSQFLFGSQFCPENSETLLPPLDAGTYLRYPKQTQQNSVDNEPSIFTKYQAKPQLFGGDTKGEGLFSLPLPVGKPKGLSKQFEEKKRRATDQSDSETLHNFVSHFPEVIHKLQTAVEKSEEHLSSRSQSILDSVETIAKTFQETARVQHDLMVEAVKDKGSVEQAVLEIQRACAARQAEFMEMKSTLKNLEVLVVQQSKDFQQFCDNLGQLIVPSVLGELKKFTSVPQVVGHLKDSASQTSPSLTQSHHYPRQEPYPSEEPATWQGQEPPAGNSSRGSQRPTEFGVWDEGAESDVFQKATLPTDRPHRGSEHVKGKAVQTYCKNWVMTSRSLSNHFSVPDQKAGSEQDLTAPGASQLDCESEARVEGICPTYEAQSKCALDSFEQSAAEQKRGRTCRKRRRGKKPQPRRAKRGRLLARVQKQTSGEACAITAERPCPQSSVCSSQGPLICWPPLRSSTKSACHILGGRGETSMTAGAVQGSLLKSSQHSSTDSSSQEDQQINWFSDISLENLEPPLCKKGGKNLLSDPDFDSSDDNF", "length": 574 }, "evidence": [ { "id": "F1MGS3", "url": "https://omabrowser.org/oma/group/F1MGS3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6PDM4-1", "protein_name": "Interactor of HORMAD1 protein 1", "gene_name": "Iho1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNFNVWNVKEMLSIPSGSGITKPSNWNNNQTDCSLSDSQFLFGSQFCPENSETLLPSLDAGACLRHPKQTQQNSVDSEPSIFIKYQAKPQLLGGDTKDESLFSLPLPVGKSKGLSKQFEEKKRRATDQSDSETLHSFVSHFPEVINKLQTSVEKTEENLSSRSQSILDSVETIAKTFQETARVQHDLMVESVRDKGSMEQAILEIQRTCAARQAEFMEMKSTLKNLEVLVVEQTKNLQQFCDNLSQLIVPGILEELKKFTSVPQVAGHLKDSTSQTSPSLTQSLHFTRQEKHPSEEPATWQAQEAPAGNPSTSSQRPGECGVWDEGAESGVFQKAALPTDGLHRGDGHVKNKTVPTYCKNWVMTTRSVSNHFSNLPSQRAGNGQGLMAQGASQRDVSKFEARVKNACPEYGPQSMCSFDSLEQSATEQKGRPCRKRRRGKKQQPQRSKRGGLLDRKQGQTSKAACAFIARHHCPQSPVCDPQGPLICWLTPRSSTKSTCHILGGTGETSQTARAAQGNLVQHSQRSSTDSSSQGDQQINWFSDLSLENLEPPQCKKGGTNLLCDPDFDSSDDNF", "length": 574 }, "evidence": [ { "id": "F1MGS3", "url": "https://omabrowser.org/oma/group/F1MGS3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IYA8-1", "protein_name": "Interactor of HORMAD1 protein 1", "gene_name": "IHO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNFNVWNIKEMLSIPSGSGNKKSSNWNNNQNDYSSLSDSQFLFGSQFCPENSETLSAPLDFGAHLRHSKQSQQNYLEGEPSIFTKYQTKPQLFGGDIKDGGLFPPPLSVGKSKGLLEQFEEKKKRAKDKCDSETLYNFVSNVRESILRLQTSVEKSEDHLSSRSQSILDSLETVAKTLQETIQAQNDLVFEAVQDKGNMEQAILEMKKRFEARQGEFIEMKSNLKHLEVLVAQQSQEFQQLCEQLGQLNVPSVLAELKRLISVPPVKDSASQTSPPLAQSLNLTRQEKYTSEKPVLWQAQALPAAWNPGMGSLQPGEFDVWGEGAKNDDLQEEAALPAFGSHERNRHVKDKVVQTNCKNWAVTKTGAKNHGSSVPGHKIPSDRDLVSQGASQLTSLEINFSTSIKNACQKYQAQSMFLCDPREHLVIKQKDGTVEMRGKDKKQQPRKAHRAHRGRLIASKQKQIPIQTCKFNSKYQSPQPAISVPQSPFLGQQEPRAQPLHLQCPRSPRKPVCPILGGTVMPNKTVRAVQGRLLQLSRCSSQDNWLLSSSSQGDHQMSWFSDLNLGCSETPLCKEAGKNLLYDLGFDSSDDDGF", "length": 594 }, "evidence": [ { "id": "F1MGS3", "url": "https://omabrowser.org/oma/group/F1MGS3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA recombination", "id": "GO:0006310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006310", "evidence": [ { "database": "UniProtKB", "id": "F1MGS3", "url": "https://www.uniprot.org/uniprotkb/F1MGS3" } ], "pmid": "" }, { "name": "meiotic DNA double-strand break formation", "id": "GO:0042138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042138", "evidence": [ { "database": "UniProtKB", "id": "F1MGS3", "url": "https://www.uniprot.org/uniprotkb/F1MGS3" } ], "pmid": "" }, { "name": "regulation of homologous chromosome segregation", "id": "GO:0060629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060629", "evidence": [ { "database": "UniProtKB", "id": "F1MGS3", "url": "https://www.uniprot.org/uniprotkb/F1MGS3" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "F1MGS3", "url": "https://www.uniprot.org/uniprotkb/F1MGS3" } ], "pmid": "" }, { "name": "oogenesis", "id": "GO:0048477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048477", "evidence": [ { "database": "UniProtKB", "id": "F1MGS3", "url": "https://www.uniprot.org/uniprotkb/F1MGS3" } ], "pmid": "" }, { "name": "homologous chromosome pairing at meiosis", "id": "GO:0007129", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007129", "evidence": [ { "database": "UniProtKB", "id": "F1MGS3", "url": "https://www.uniprot.org/uniprotkb/F1MGS3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "condensed nuclear chromosome", "id": "GO:0000794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000794", "evidence": [ { "database": "UniProtKB", "id": "F1MGS3", "url": "https://www.uniprot.org/uniprotkb/F1MGS3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 29, "end_pos": 31, "annotation": "n_glycosylation_sequon" }, { "start_pos": 405, "end_pos": 407, "annotation": "n_glycosylation_sequon" }, { "start_pos": 413, "end_pos": 415, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], 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"tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MFD4-1", "uniprot_ac": "F1MFD4", "uniprot_id": "F1MFD4_BOVIN", "mass": { "chemical_mass": 35361.0, "monoisotopic_mass": 35361.0 }, "refseq": {}, "gene_names": [ { "name": "LOC618409", "type": "recommended", "evidence": [ { "id": "F1MFD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFD4" } ] } ], "protein_names": [ { "name": "Forkhead box protein L2", "type": "recommended", "evidence": [ { "id": "F1MFD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFD4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFD4", "url": "https://www.uniprot.org/uniprotkb/F1MFD4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC618409", "url": "https://www.uniprot.org/uniprotkb/F1MFD4", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000009206", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009206", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20037", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20037", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030456", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030456", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QKEPWGP", "url": "https://omabrowser.org/oma/group/QKEPWGP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MFD4", "url": "https://www.orthodb.org/?gene=F1MFD4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11829:SF370", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11829:SF370", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00250", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00250", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T6F8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6F8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T6F8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6F8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFD4", "url": "https://www.uniprot.org/uniprotkb/F1MFD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFD4-1", "url": "https://www.uniprot.org/uniprotkb/F1MFD4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQQPPPPGPLAPAAEPTKPPYSYIALIAMAIQNSPGQRATLSGIYRYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDPDCHDMFEHGSFLRRRRRFTRRAGAEGTKGPTKARRGPLRATSQDPGAPDVAASRQCPFPPEPLEPKGLSYGGLVGALPASMCPATTNARPQTPSEAKEMPTPKAAGPGELPVATSSSSCPAFGFPTSFSEAEGFSKAPAPILTPEATIGSSYQCRLQALNFCMGTDPGLEHLLASAAPSPAPSTPPASLRAPLPLPADPKEPWVAGSFPVQGSSSYPLGLTPCLYRTPGMFFFE", "length": 330, "header": "tr|F1MFD4-1|F1MFD4_BOVIN Isoform 1 of Forkhead box protein L2 OS=Bos taurus OX=9913 GN=LOC618409 PE=4 SV=1 CANONICAL=F1MFD4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T6F8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T6F8/entry", "sequence": { "sequence": "MVARSPNTRSGCALVRSTRGPRTSPRSGSLWPMWSQSSPGSSSCTRRSTASYIALIAMAIQNSPGQRATLSGIYRYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDPDCHDMFEHGSFLRRRRRFTRRAGAEGTKGPTKARRGPLRATSQDPGAPDVAASRQCPFPPEPLEPKGLSYGGLVGALPASMCPATTNARPQTPSEAKEMPTPKAAGPGELPVATSSSSCPAFGFPTSFSEAEGFSKAPAPILTPEATIGSSYQCRLQALNFCMGTDPGLEHLLASAAPSPAPSTPPASLRAPLPLPADPKEPWVAGSFPVQGSSSYPLGLTPCLYRTPGMFFFE", "length": 359, "header": "tr|A0AAA9T6F8-1|F1MFD4_BOVIN Computationally mapped isoform of Forkhead box protein L2 OS=Bos taurus OX=9913 GN=LOC618409 PE=4 SV=1 CANONICAL=F1MFD4-1" }, "locus": { "chromosome": "13", "start_pos": 61383278, "end_pos": 61378889, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111821.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111821.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092318.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092318.1" } ] } }, { "isoform_ac": "A0AAA9TNL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL4/entry", "sequence": { "sequence": "MVARSPNTRSGCALVRSTRGPRTSPRSGSLWPIYIALIAMAIQNSPGQRATLSGIYRYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDPDCHDMFEHGSFLRRRRRFTRRAGAEGTKGPTKARRGPLRATSQDPGAPDVAASRQCPFPPEPLEPKGLSYGGLVGALPASMCPATTNARPQTPSEAKEMPTPKAAGPGELPVATSSSSCPAFGFPTSFSEAEGFSKAPAPILTPEATIGSSYQCRLQALNFCMGTDPGLEHLLASAAPSPAPSTPPASLRAPLPLPADPKEPWVAGSFPVQGSSSYPLGLTPCLYRTPGMFFFE", "length": 341, "header": "tr|A0AAA9TNL4-1|F1MFD4_BOVIN Computationally mapped isoform of Forkhead box protein L2 OS=Bos taurus OX=9913 GN=LOC618409 PE=4 SV=1 CANONICAL=F1MFD4-1" }, "locus": { "chromosome": "13", "start_pos": 61383278, "end_pos": 61378889, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121443.1", "url": "https://www.ensembl.org/id/ENSBTAT00000121443.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099952.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099952.1" } ] } }, { "isoform_ac": "F1MFD4-1", "url": "https://www.uniprot.org/uniprotkb/F1MFD4/entry", "sequence": { "sequence": "MQQPPPPGPLAPAAEPTKPPYSYIALIAMAIQNSPGQRATLSGIYRYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDPDCHDMFEHGSFLRRRRRFTRRAGAEGTKGPTKARRGPLRATSQDPGAPDVAASRQCPFPPEPLEPKGLSYGGLVGALPASMCPATTNARPQTPSEAKEMPTPKAAGPGELPVATSSSSCPAFGFPTSFSEAEGFSKAPAPILTPEATIGSSYQCRLQALNFCMGTDPGLEHLLASAAPSPAPSTPPASLRAPLPLPADPKEPWVAGSFPVQGSSSYPLGLTPCLYRTPGMFFFE", "length": 330, "header": "tr|F1MFD4-1|F1MFD4_BOVIN Isoform 1 of Forkhead box protein L2 OS=Bos taurus OX=9913 GN=LOC618409 PE=4 SV=1 CANONICAL=F1MFD4-1" }, "locus": { "chromosome": "13", "start_pos": 61379878, "end_pos": 61378889, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103586.2", "url": "https://www.ensembl.org/id/ENSBTAT00000103586.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075139.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075139.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 280, "start_aa": "Thr", "end_pos": 280, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr280", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZYV2-1", "protein_name": "Forkhead box protein L2", "gene_name": "FOXS1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MQQQPPPGPPAPAAEPTKPPYSYIALIAMAIQSSPGQRATLSGIYRYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDPDCHDMFEHGSFLRRRRRFTRRAGAEVAKGPAKARRGALRATGQDPGAPDAATGRQGPFLPELPEPKGLSFGGLVGALPASMCPATTDARPRPPSEPKEMPTSKLAGPGELPVATSSSPCPAFGFPASFSEAEGFSKAPAPILAPEAAVGSSYQCRLQALNFCMGTDPGFEHLLASAAPSPAPPTPPASLRAPLPLPADPKEPWVAGSFPVQGGSGYPLGLTPCLYRTPGMFFFE", "length": 330 }, "evidence": [ { "id": "F1MFD4", "url": "https://omabrowser.org/oma/group/F1MFD4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HEA4-1", "protein_name": "Forkhead box protein S1", "gene_name": "Foxs1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MQQQPSPRSLAPSAEPTKPPYSYIALIAMAIQSSPGQRATLSGIYGYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDPDCHDMFQHGSFLRRRRRFTKRTGAQGTKGPVKADHRLLRAASPDPGAPNTTTGRLCPFPPEAPNPKGLNFGDLMGSLPASICPATSDARPQLATESKEMCSPKSACPRELTEATSPSPCPAFSFSAAFPEAESLGKAPTPGVAPEGAGSSYQCRMQALNFCMGTDSGLEHLLASAVPAPAPSTPSASHRAPLPLPADSKEPWVTGNFPVQGGSGYPLALPPCLYRTPGMFFFE", "length": 329 }, "evidence": [ { "id": "F1MFD4", "url": "https://omabrowser.org/oma/group/F1MFD4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O43638-1", "protein_name": "Forkhead box protein S1", "gene_name": "FOXS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQQQPLPGPGAPTTEPTKPPYSYIALIAMAIQSSPGQRATLSGIYRYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDPDCHDMFEHGSFLRRRRRFTRQTGAEGTRGPAKARRGPLRATSQDPGVPNATTGRQCSFPPELPDPKGLSFGGLVGAMPASMCPATTDGRPRPPMEPKEISTPKPACPGELPVATSSSSCPAFGFPAGFSEAESFNKAPTPVLSPESGIGSSYQCRLQALNFCMGADPGLEHLLASAAPSPAPPTPPGSLRAPLPLPTDHKEPWVAGGFPVQGGSGYPLGLTPCLYRTPGMFFFE", "length": 330 }, "evidence": [ { "id": "F1MFD4", "url": "https://omabrowser.org/oma/group/F1MFD4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q61574-1", "protein_name": "Forkhead box protein S1", "gene_name": "Foxs1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQKQPSPESLAPSAEPTKPPYSYIALIAMAIQSSPGQRATLSGIYRYIMGRFAFYRHNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDPDCHDMFQHGSFLRRRRRFTKRTGAQGTKGPVKIDHRPHRATSPDPGAPKTTTGRLCPFPQEVPNPKGLSFEGLMGSLPANMSSTTSDVRPQLPTGPKEMCSAKSGGPRELSEATSPSPCPAFGFSSAFSDAESLGKAPTPGVAPESVGSSYQCRMQTLNFCMGTDPGLEHLLVSSVPTPGSSTPSASHRAPLPLPADSKEPWVAGSFPVQGGSGYPLGLPPCLYRTPGMFFFE", "length": 329 }, "evidence": [ { "id": "F1MFD4", "url": "https://omabrowser.org/oma/group/F1MFD4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MFD4", "url": "https://www.uniprot.org/uniprotkb/F1MFD4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": 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phosphatase 5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002698781", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698781" } ] } ], "function": [ { "annotation": "Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules.", "evidence": [ { "database": "UniProtKB", "id": "F1MH11", "url": "https://www.uniprot.org/uniprotkb/F1MH11#function" }, { "database": "UniProtKB", "id": "ARBA00056498", "url": "https://www.uniprot.org/uniprotkb/ARBA00056498#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MH11", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLPP5", "url": "https://www.uniprot.org/uniprotkb/F1MH11", "locus": { "chromosome": "27", "start_pos": 33416455, "end_pos": 33421676, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000027635", "url": "https://www.ensembl.org/id/ENSBTAG00000027635" } ] } } ], "crossref": [ { "id": "F1MH11", "url": "https://alphafold.ebi.ac.uk/entry/F1MH11", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000027635", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000027635", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03390", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03390", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616337", "url": "https://www.ncbi.nlm.nih.gov/gene/616337", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000326", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000326", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616337", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616337", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CTPLIVI", "url": "https://omabrowser.org/oma/group/CTPLIVI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MH11", "url": "https://www.orthodb.org/?gene=F1MH11", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10165", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10165", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10165:SF87", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10165:SF87", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01569", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01569", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2029485", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029485", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002698781", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698781", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "27429", "url": "https://www.rhea-db.org/rhea/27429", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "27449", "url": "https://www.rhea-db.org/rhea/27449", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "39835", "url": "https://www.rhea-db.org/rhea/39835", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "42856", "url": "https://www.rhea-db.org/rhea/42856", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "42860", "url": "https://www.rhea-db.org/rhea/42860", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T7D9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7D9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7D9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7D9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH11", "url": "https://www.uniprot.org/uniprotkb/F1MH11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH11-1", "url": "https://www.uniprot.org/uniprotkb/F1MH11-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKGKAAALAAELGVRLALFAVFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYLPTKPMFVIAFLAPLAPVLLARCLKAADAADSRQACLAASLALALNGIFTNTIKLIVGRPRPDFFYRCFPDGQAHGDLMCTGDKAVVNEGRKSFPSGHASFAFAGLAFASFYLAGKLHCFTPRGRGKSWRFCSFLSPLLFAAVIALSRTCDYKHHWQDVLAGSAIGLTFAYSCYRQYYPPLTDAECHRPLPLSPALPAPQKQPRDLQPFCV", "length": 264, "header": "tr|F1MH11-1|F1MH11_BOVIN Isoform 1 of Phospholipid phosphatase 5 OS=Bos taurus OX=9913 GN=PLPP5 PE=3 SV=2 CANONICAL=F1MH11-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7D9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7D9/entry", "sequence": { "sequence": "MGKGKAAALAAELGVRLALFAVFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYLPTKPMFVIAFLAPLAPVLLARCLKAADAADSRQACLAASLALALNGIFTNTIKLIVGRPRPDFFYRCFPDGQAHGDLMCTGDKAVVNEGRKSFPSGHASFAFAGLAFASFYLAGKLHCFTPRGRGKSWRFCSFLSPLLFAAVIALSRTCDYKHHWQEPFEW", "length": 215, "header": "tr|A0AAA9T7D9-1|F1MH11_BOVIN Computationally mapped isoform of Phospholipid phosphatase 5 OS=Bos taurus OX=9913 GN=PLPP5 PE=3 SV=1 CANONICAL=F1MH11-1" }, "locus": { "chromosome": "27", "start_pos": 33421404, "end_pos": 33417924, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114385.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114385.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091748.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091748.1" } ] } }, { "isoform_ac": "F1MH11-1", "url": "https://www.uniprot.org/uniprotkb/F1MH11/entry", "sequence": { "sequence": "MGKGKAAALAAELGVRLALFAVFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYLPTKPMFVIAFLAPLAPVLLARCLKAADAADSRQACLAASLALALNGIFTNTIKLIVGRPRPDFFYRCFPDGQAHGDLMCTGDKAVVNEGRKSFPSGHASFAFAGLAFASFYLAGKLHCFTPRGRGKSWRFCSFLSPLLFAAVIALSRTCDYKHHWQDVLAGSAIGLTFAYSCYRQYYPPLTDAECHRPLPLSPALPAPQKQPRDLQPFCV", "length": 264, "header": "tr|F1MH11-1|F1MH11_BOVIN Isoform 1 of Phospholipid phosphatase 5 OS=Bos taurus OX=9913 GN=PLPP5 PE=3 SV=2 CANONICAL=F1MH11-1" }, "locus": { "chromosome": "27", "start_pos": 33421404, "end_pos": 33417459, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039797.5", "url": "https://www.ensembl.org/id/ENSBTAT00000039797.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039585.3", "url": "https://www.ensembl.org/id/ENSBTAP00000039585.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:616337", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616337", "resource": "KEGG Pathway" }, { "id": "R-BTA-2029485", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029485", "resource": "Reactome", "description": "Role of phospholipids in phagocytosis" } ], "orthologs": [ { "uniprot_canonical_ac": "Q3UMZ3-1", "protein_name": "Phospholipid phosphatase 5", "gene_name": "Plpp5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGTAALGAELGVRVLLFVAFLVTELLPPFQRRIQPEELWLYRNPYVEAEYFPTGRMFVIAFLTPLSLIFLAKFLRKADATDSKQACLAASLALALNGVFTNIIKLIVGRPRPDFFYRCFPDGLAHSDLTCTGDEDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRGKSWRLCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPLTDVECHKPFQDKHKLPSSQKPSELHHLEI", "length": 260 }, "evidence": [ { "id": "F1MH11", "url": "https://omabrowser.org/oma/group/F1MH11/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NEB5-1", "protein_name": "Phospholipid phosphatase 5", "gene_name": "PLPP5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGKAAAAVAFGAEVGVRLALFAAFLVTELLPPFQRLIQPEEMWLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGMTFAYVCYRQYYPPLTDAECHKPFQDKLVLSTAQKPGDSYCFDI", "length": 264 }, "evidence": [ { "id": "F1MH11", "url": "https://omabrowser.org/oma/group/F1MH11/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MH11", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MH11", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "phospholipid metabolic process", "id": "GO:0006644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006644", "evidence": [ { "database": "UniProtKB", "id": "F1MH11", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ], "pmid": "" }, { "name": "phospholipid dephosphorylation", "id": "GO:0046839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046839", "evidence": [ { "database": "UniProtKB", "id": "F1MH11", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphatidate phosphatase activity", "id": "GO:0008195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008195", "evidence": [ { "database": "UniProtKB", "id": "F1MH11", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ], "pmid": "" }, { "name": "diacylglycerol diphosphate phosphatase activity", "id": "GO:0000810", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000810", "evidence": [ { "database": "UniProtKB", "id": "F1MH11", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "27429", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BPE8-1", "A0A3Q1M9U2-1", "E1BLQ9-1", "A0AAA9STE8-1", "Q3SZE3-1", "Q2HJ61-1", "F1MH11-1", "F1MXQ6-1" ], "evidence": [ { "id": "27429", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/27429" } ] }, { "id": "27449", "name": "", "equation": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9STE8-1", "F1MH11-1", "F1MXQ6-1" ], "evidence": [ { "id": "27449", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/27449" } ] }, { "id": "39835", "name": "", "equation": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9STE8-1", "A6H730-1", "A6H757-1", "F1MH11-1", "F1MXQ6-1" ], "evidence": [ { "id": "39835", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39835" } ] }, { "id": "42856", "name": "", "equation": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MH11-1", "F1MXQ6-1" ], "evidence": [ { "id": "42856", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42856" } ] }, { "id": "42860", "name": "", "equation": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctanoyl-sn-glycerol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MH11-1", "F1MXQ6-1" ], "evidence": [ { "id": "42860", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42860" } ] }, { "id": "R-BTA-2029468", "name": "Conversion of PA into DAG by PAP-1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MH11-1", "F1MXQ6-1" ], "evidence": [ { "id": "R-BTA-2029468", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2029468" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M9U2", "gene_name": "LPIN2", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "A0A3Q1M9U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9U2" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "A0A3Q1M9U2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9U2" } ] } ] }, { "uniprot_ac": "A0AAA9STE8", "gene_name": "PLPP1", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "A0AAA9STE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE8" } ] }, { "ec_number": "3.1.3.106", "activity": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "A0AAA9STE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE8" } ] }, { "ec_number": "3.6.1.75", "activity": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE8" } ] }, { "ec_number": "3.6.1.75", "activity": "", "evidence": [ { "id": "A0AAA9STE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE8" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "A0AAA9STE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE8" } ] }, { "ec_number": "3.1.3.106", "activity": "", "evidence": [ { "id": "A0AAA9STE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STE8" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A6H757", "gene_name": "ACP6", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] }, { "ec_number": "3.1.3.106", "activity": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] }, { "ec_number": "3.1.3.106", "activity": "", "evidence": [ { "id": "A6H757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H757" } ] } ] }, { "uniprot_ac": "E1BLQ9", "gene_name": "LPIN3", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "E1BLQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ9" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "E1BLQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ9" } ] } ] }, { "uniprot_ac": "E1BPE8", "gene_name": "LPIN1", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "E1BPE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "E1BPE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPE8" } ] } ] }, { "uniprot_ac": "F1MH11", "gene_name": "PLPP5", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "F1MH11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ] }, { "ec_number": "3.6.1.75", "activity": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + phosphate + H(+).", "evidence": [ { "id": "F1MH11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "F1MH11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ] }, { "ec_number": "3.6.1.75", "activity": "", "evidence": [ { "id": "F1MH11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH11" } ] } ] }, { "uniprot_ac": "F1MXQ6", "gene_name": "PLPP4", "activity": [ { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "F1MXQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXQ6" } ] }, { "ec_number": "3.6.1.75", "activity": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + phosphate + H(+).", "evidence": [ { "id": "F1MXQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXQ6" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "F1MXQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXQ6" } ] }, { "ec_number": "3.6.1.75", "activity": "", "evidence": [ { "id": "F1MXQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXQ6" } ] } ] }, { "uniprot_ac": "Q2HJ61", "gene_name": "PLPP2", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q2HJ61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ61" } ] }, { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "Q2HJ61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ61" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "Q2HJ61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ61" } ] } ] }, { "uniprot_ac": "Q3SZE3", "gene_name": "PLPP3", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q3SZE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE3" } ] }, { "ec_number": "3.1.3.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "Q3SZE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE3" } ] }, { "ec_number": "3.1.3.4", "activity": "", "evidence": [ { "id": "Q3SZE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZE3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MH11-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 264, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MH11-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MH11" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MH11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH11" }, { "id": "SM00014", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00014" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosphatidic acid phosphatase type 2/haloperoxidase", "eco_id": "ECO_0000259", "start_pos": 88, "end_pos": 227, "start_aa": "Ala", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.4", "ec_name": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate.", "evidence": [ { "id": "3.1.3.4", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4" }, { "id": "3.1.3.4", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.4" } ] }, { "ec_number": "3.6.1.75", "ec_name": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + phosphate + H(+).", "evidence": [ { "id": "3.6.1.75", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75" }, { "id": "3.6.1.75", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.6.1.75" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"uniprot_ac": "F1MFZ5", "uniprot_id": "F1MFZ5_BOVIN", "mass": { "chemical_mass": 103483.0, "monoisotopic_mass": 103483.0 }, "refseq": {}, "gene_names": [ { "name": "UNC45B", "type": "recommended", "evidence": [ { "id": "F1MFZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5" } ] } ], "protein_names": [ { "name": "Protein unc-45 homolog B", "type": "recommended", "evidence": [ { "id": "F1MFZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development.", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ5", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5#function" }, { "database": "UniProtKB", "id": "ARBA00053758", "url": "https://www.uniprot.org/uniprotkb/ARBA00053758#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFZ5", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UNC45B", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5", "locus": { "chromosome": "19", "start_pos": 14914285, "end_pos": 14946535, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002898", "url": "https://www.ensembl.org/id/ENSBTAG00000002898" } ] } } ], "crossref": [ { "id": "F1MFZ5", "url": "https://alphafold.ebi.ac.uk/entry/F1MFZ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002898", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002898", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MFZ5", "url": "https://www.orthodb.org/?gene=F1MFZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45994", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45994", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45994:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45994:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11701", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11701", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T7Z3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7Z3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFZ5", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFZ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEAEAMQLKEEGNQHFQLQDYKAATKSYSQALKLTKDKALLATLYRNRAACGLKMESYVQAASDASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPQNQSFQETLRRLNTSIQEKLRVQFSTDSRVQTMFEILLDRNSEADKLEKAANNLIVLSREEAGAERIFQNNGVALLMQLLDTKRPELMLAAVRTLSGVCSSHRARATATLHAVRIDRICSLMAVESEEMSLAVCNLLQGIIDALSGEDKQEHRGKEEALVLDSKKDLKQITNHLLDMLVSKKVSGQGRDQALNLLNKNVPRKDLAIHDNSRTIYVVDNGLRKILKVVGQVPDLPSCLPLTDNTRMLASILINKLYDDLRCDPERDHFRKICEEHITGTFDPQDMDKNVIAIQTVSGILQGPFDLGNQLLGLKGVMEMMVALCGSERETDQLVAVEALIHASTKLSRATFIITNGVSLLKEIYKTTKNEKIKIRALVGLCKLGSAGGTDYALRQFAEGSTEKLAKQCRKWLCNASIDTRTRKWAVEGLAYLTLDADVKDDFVQDIPALQAMFELAKASTPDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFSKQHVPEEHPKDKKDFVDMRVKRLLKAGVTSALVCMVKADNAILTDQTKELLARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHALAKIAAVSNPDIAFPGERVYEVVRPLVSLLNTQRDGLQNYEALLGLTNLSGRSDKLRKKIFKEKALPDIENYMFENHDQLRQAATECMCNMVVNKEVQERFLADGNDRLKLVVLLCGEDDDKLQNAAAGALAMLTAAHKKLCFKMTEVTTQWLEILQRLCLHDRLSVQHRGLVIAYNLLAADAELAKKLVESELLEILTVVGKQEPDEKRAAVVQTARECLIKCMDYGFIKPVA", "length": 931, "header": "tr|F1MFZ5-1|F1MFZ5_BOVIN Isoform 1 of Protein unc-45 homolog B OS=Bos taurus OX=9913 GN=UNC45B PE=4 SV=3 CANONICAL=F1MFZ5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7Z3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z3/entry", "sequence": { "sequence": 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PE=4 SV=1 CANONICAL=F1MFZ5-1" }, "locus": { "chromosome": "19", "start_pos": 14946533, "end_pos": 14914707, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128755.1", "url": "https://www.ensembl.org/id/ENSBTAT00000128755.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092730.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092730.1" } ] } }, { "isoform_ac": "F1MFZ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5/entry", "sequence": { "sequence": "MAEAEAMQLKEEGNQHFQLQDYKAATKSYSQALKLTKDKALLATLYRNRAACGLKMESYVQAASDASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPQNQSFQETLRRLNTSIQEKLRVQFSTDSRVQTMFEILLDRNSEADKLEKAANNLIVLSREEAGAERIFQNNGVALLMQLLDTKRPELMLAAVRTLSGVCSSHRARATATLHAVRIDRICSLMAVESEEMSLAVCNLLQGIIDALSGEDKQEHRGKEEALVLDSKKDLKQITNHLLDMLVSKKVSGQGRDQALNLLNKNVPRKDLAIHDNSRTIYVVDNGLRKILKVVGQVPDLPSCLPLTDNTRMLASILINKLYDDLRCDPERDHFRKICEEHITGTFDPQDMDKNVIAIQTVSGILQGPFDLGNQLLGLKGVMEMMVALCGSERETDQLVAVEALIHASTKLSRATFIITNGVSLLKEIYKTTKNEKIKIRALVGLCKLGSAGGTDYALRQFAEGSTEKLAKQCRKWLCNASIDTRTRKWAVEGLAYLTLDADVKDDFVQDIPALQAMFELAKASTPDKTILYSVATTLVNCTNSYDVKEVIPELVQLAKFSKQHVPEEHPKDKKDFVDMRVKRLLKAGVTSALVCMVKADNAILTDQTKELLARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHALAKIAAVSNPDIAFPGERVYEVVRPLVSLLNTQRDGLQNYEALLGLTNLSGRSDKLRKKIFKEKALPDIENYMFENHDQLRQAATECMCNMVVNKEVQERFLADGNDRLKLVVLLCGEDDDKLQNAAAGALAMLTAAHKKLCFKMTEVTTQWLEILQRLCLHDRLSVQHRGLVIAYNLLAADAELAKKLVESELLEILTVVGKQEPDEKRAAVVQTARECLIKCMDYGFIKPVA", "length": 931, "header": "tr|F1MFZ5-1|F1MFZ5_BOVIN Isoform 1 of Protein unc-45 homolog B OS=Bos taurus OX=9913 GN=UNC45B PE=4 SV=3 CANONICAL=F1MFZ5-1" }, "locus": { "chromosome": "19", "start_pos": 14946533, "end_pos": 14914707, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003766.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003766.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003766.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003766.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ5", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5" } ], "pmid": "" }, { "name": "muscle organ development", "id": "GO:0007517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007517", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ5", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5" } ], "pmid": "" }, { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ5", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ5", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5" } ], "pmid": "" }, { "name": "Z disc", "id": "GO:0030018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030018", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ5", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5" } ], "pmid": "" }, { "name": "A band", "id": "GO:0031672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031672", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ5", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ5", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ5", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "Hsp90 protein binding", "id": "GO:0051879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051879", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ5", "url": "https://www.uniprot.org/uniprotkb/F1MFZ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 110, "end_pos": 112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 121, "end_pos": 123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 520, "end_pos": 522, "annotation": "n_glycosylation_sequon" }, { "start_pos": 581, "end_pos": 583, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" }, { "start_pos": 745, "end_pos": 747, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MFZ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 931, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MFZ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MFZ5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFZ5", "database": "UniProtKB", "url": 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"graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MF85-1", "uniprot_ac": "F1MF85", "uniprot_id": "F1MF85_BOVIN", "mass": { "chemical_mass": 57306.0, "monoisotopic_mass": 57306.0 }, "refseq": { "ac": "NP_001193911", "name": "cell division cycle protein 20 homolog B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193911" }, "gene_names": [ { "name": "CDC20B", "type": "recommended", "evidence": [ { "id": "F1MF85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF85" } ] }, { "name": "CDC20B", "type": "synonym", "evidence": [ { "id": "NP_001193911", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193911" } ] } ], "protein_names": [ { "name": "Cell division cycle 20B", "type": "synonym", "evidence": [ { "id": "F1MF85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF85/entry#names_and_taxonomy" } ] }, { "name": "cell division cycle 20 homolog B", "type": "synonym", "evidence": [ { "id": "NP_001193911", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193911" } ] }, { "name": "cell division cycle protein 20 homolog B", "type": "synonym", "evidence": [ { "id": "NP_001193911", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193911" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MF85", "url": "https://www.uniprot.org/uniprotkb/F1MF85" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDC20B", "url": "https://www.uniprot.org/uniprotkb/F1MF85", "locus": { "chromosome": "20", "start_pos": 24005261, "end_pos": 23940884, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021959", "url": "https://www.ensembl.org/id/ENSBTAG00000021959" } ] } } ], "crossref": [ 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"id": "IPR033010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056150", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056150", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522049", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522049", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GTASVWK", "url": "https://omabrowser.org/oma/group/GTASVWK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MF85", "url": "https://www.orthodb.org/?gene=F1MF85", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19918", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19918", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19918:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19918:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12894", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12894", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24807", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24807", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193911", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T9R7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9R7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9R7-1", "url": 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"ENSBTAT00000093286.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093286.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092658.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092658.1" } ] } }, { "isoform_ac": "F1MF85-1", "url": "https://www.uniprot.org/uniprotkb/F1MF85/entry", "sequence": { "sequence": "MEWKLERAARRRVRTEEEILWEDVMRVLDKDMKQRRGQVSPKVFNVVNTTYSNFTSNLAKRLSAEVPVASSPITTRWRQSQAGDVTALSFGEEHSTADLPETVLKMTPEKETLTPGSYKEPLKTPNKGSSGTNNSAFQFGKAPHALNRGWKDKVASKDPKCLNQLFSTQNVAQQVNGSMQFCERSQCTWKGCRDGVRDGYFQRFSDINYSILQPEVKIHLTGLRNDYYLNILDWNFQNLIAIALGSSVYVWNGDNHNRIENMYFSLPCNYVSSVSWMTEGTCLAVGTSEGEIQLWDLVTKKRLRNMLGHLSVVGALSWNHYILSSGSRLGRVYHHDVRVAQHHVGTLQHTQAVCGLKWAPGGRLLSSGCSDGLLTIWPYDPGANAQGPPLKVIHQSTAVKAIDWCPWQTEVLAVGGGMKDGRLHILDISTGQSIQTPSTDSQICSLTWLPKTKEIATGQGSPKNDVTMWTCPGLARSRGFFDHRGRVLHLALSPDQMRVFSAAADGTACIWNCC", "length": 514, "header": "tr|F1MF85-1|F1MF85_BOVIN Isoform 1 of Cell division cycle 20B OS=Bos taurus OX=9913 GN=CDC20B PE=3 SV=2 CANONICAL=F1MF85-1" }, "locus": { "chromosome": "20", "start_pos": 24005187, "end_pos": 23941051, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029276.5", "url": "https://www.ensembl.org/id/ENSBTAT00000029276.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029276.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029276.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522049", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522049", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3Z3I0-1", "protein_name": "Cell division cycle protein 20 homolog B", "gene_name": "Cdc20b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEWKLQRTARRKIRTEEEMLWENIMRVLANGMKQQRNQGSPKELDSVAVTYSSFKSNFVKRLSAEIPVASSPITTRWQLSPARDPESSSSVEEGPPSHTPESLASGLKITPAADTLTLRSHNKNSPKTLSKGSSEVNNSTLRFCKTPLAGDRGWKENLATKGQRCLNQPFSTQKGAQQIDGKMHLCEESRCVRTGCRFGARDEFYLRRFSGVYHSTCQPEVKIHLTGLRNDYYLNTLDWSSQNLVAVALGTSVYIWNGQNHSWIENIDLSVCCHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSWNHCTLSSGSRLGRVHHHDVRVAQHRVGTLYHKEAVCSLKWSPDGRLLSSGCNDGLLTIWPHDPGAGVQGLPLKVIPQSTAVKAMEWCPWQSEVLAVGGGVKDGCLHVLDINTGKNIQTPSTQSQICSLIWLPKTKEIATGQGAPKNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGTACVWKCC", "length": 519 }, "evidence": [ { "id": "F1MF85", "url": "https://omabrowser.org/oma/group/F1MF85/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86Y33-1", "protein_name": "Cell division cycle protein 20 homolog B", "gene_name": "CDC20B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAKRLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGSRKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANGKMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGGGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSRSGGFFGHRGRVLHLSLSPDQTRVFSAAADGTASVWNCY", "length": 519 }, "evidence": [ { "id": "F1MF85", "url": "https://omabrowser.org/oma/group/F1MF85/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ubiquitin-protein transferase activator activity", "id": "GO:0097027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097027", "evidence": [ { "database": "UniProtKB", "id": "F1MF85", "url": 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"UniProtKB", "id": "F1MF85", "url": "https://www.uniprot.org/uniprotkb/F1MF85" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "anaphase-promoting complex-dependent catabolic process", "id": "GO:0031145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031145", "evidence": [ { "database": "UniProtKB", "id": "F1MF85", "url": "https://www.uniprot.org/uniprotkb/F1MF85" } ], "pmid": "" }, { "name": "positive regulation of anaphase-promoting complex-dependent catabolic process", "id": "GO:1905786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905786", "evidence": [ { "database": "UniProtKB", "id": "F1MF85", "url": "https://www.uniprot.org/uniprotkb/F1MF85" } ], "pmid": "" }, { "name": "de novo centriole assembly", "id": "GO:0097742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097742", "evidence": [ { "database": "UniProtKB", "id": "F1MF85", "url": "https://www.uniprot.org/uniprotkb/F1MF85" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" }, { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MF85-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 514, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MF85-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MF85" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MF85", "database": "UniProtKB", "url": 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"R-BTA-380320", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5620912", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8854518", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TAA9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TAA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME99", "url": "https://www.uniprot.org/uniprotkb/F1ME99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME99-1", "url": "https://www.uniprot.org/uniprotkb/F1ME99-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTAAERKYLNIRKRLDQLGYRQTLTVDCIPLVEKLFSDLVHTTESLRKSKLSAVKAEKESANFDFVLEPYKLENARLSKENNELYLELMKLREQSGQHIKELKTTLKKCARETADLKFLNNQYVHKLKLMEKESKAKNEKIQQLQEKNLQAVVQTPGGKKRNIAFRRQRMQIDEPVPPSEISSYPVPQPDDPYIADLLHVADNRIQELQQEVCQLQEKLAMMESELRDYNKQIELREREIERLSIALDGGRSSDILSLETRNKANEKLIAHLNIQVDFLQQANKDLEKHIQELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLKTADKELEEAKKEIKKKLSEMRNLEETIGKLQLELSLCHKEKERLSDELLIKSDLETVVHQLEQEKQRLNKKIESFAVTERELTVEIERMRLEHGIKRRDKSPSRLDTFLKGIEDERDFYKKELEKLQHIIQRRSCSRSHSTCEKTPVFKTLEKGDYDSDIHLITRERDELQRMLERFEKHMVDIQSNVKLLTAERDKLSVLYNEHLQEMSVFGKSELEKTIEHLTCVNHQLENEKCELKSKIFIMKETMESLEKKAKFQAQKLSHVAGDSSHQKTEMNSLRLVNEQLQRSLEDYQHRLNMKRSELESAQAQVKILEEKIGKLHLRMTSQNEEAHVMKKTIGVIDKEKDILQETVDEKTEKIANLHENLASKEKTITQMKITVSEYESSLNHLKETLINRDREISSLRRQLDAAHKELDEVGRSKEMSFKENRRLQDDLATMARENQQISLELEAAVQEKEEMKSRVHNYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHMNAHHAYESQISSMAKAISRLEEELRHQEDEKAAVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVTMELENIKSESELLKKQLLSERHTIKNLESLLATNRDKEFHSHLTSHEKDTEIQILKEKLTLSESKLNSQSRENTMLRAKMAQLQTDLDVLKRQISTERYERERAIQEMRRHGLRTPPLSSTMRSPLHSPEHIN", "length": 1088, "header": "tr|F1ME99-1|F1ME99_BOVIN Isoform 1 of Centrosomal protein 135 OS=Bos taurus OX=9913 GN=CEP135 PE=3 SV=4 CANONICAL=F1ME99-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TAA9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAA9/entry", "sequence": { "sequence": "MTTAAERKYLNIRKRLDQLGYRQTLTVDCIPLVEKLFSDLVHTTESLRKSKLSAVKAEKESANFDFVLEPYKLENARLSKENNELYLELMKLREQSGQHIKELKTTLKKCARETADLKFLNNQYVHKLKLMEKESKAKNEKIQQLQEKNLQAVVQTPGGKKRNIAFRRQRMQIDEPVPPSEISSYPVPQPDDPYIADLLHVADNRIQELQQEVCQLQEKLAMMESELRDYNKQIELREREIERLSIALDGGRSSDILSLETRNKANEKLIAHLNIQVDFLQQANKDLEKHIQELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLKTADKELEEAKKEIKKKLSEMRNLEETIGKLQLELSLCHKEKERLSDELLIKSDLETVVHQLEQEKQRLNKKIESFAVTERELTVEIERMRLEHGIKRRDKSPSRLDTFLKGIEDERDFYKKELEKLQHIIQRRSCSRSHSTCEKTPVFKTLEKGDYDSDIHLITRERDELQRMLERFEKHMVDIQSNVKLLTAERDKLSVLYNELENEKCELKSKIFIMKETMESLEKKAKFQAQKLSHVAGDSSHQKTEMNSLRLVNEQLQRSLEDYQHRLNMKRSELESAQAQVKILEEKIGKLHLRMTSQNEEAHVMKKTIGVIDKEKDILQETVDEKTEKIANLHENLASKEKTITQMKITVSEYESSLNHLKETLINRDREISSLRRQLDAAHKELDEVGRSKEMSFKENRRLQDDLATMARENQQISLELEAAVQEKEEMKSRVHNYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHMNAHHAYESQISSMAKAISRLEEELRHQEDEKAAVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVTMELENIKSESELLKKQLLSERHTIKNLESLLATNRDKEFHSHLTSHEKDTEIQILKEKLTLSESKLNSQSRENTMLRAKMAQLQTDLDVLKRQISTERYERERAIQEMRRHGLRTPPLSSTMRSPLHSPEHIN", "length": 1062, "header": "tr|A0AAA9TAA9-1|F1ME99_BOVIN Computationally mapped isoform of Centrosomal protein 135 OS=Bos taurus OX=9913 GN=CEP135 PE=3 SV=1 CANONICAL=F1ME99-1" }, "locus": { "chromosome": "6", "start_pos": 71427244, "end_pos": 71360600, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099437.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099437.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092908.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092908.1" } ] } }, { "isoform_ac": "F1ME99-1", "url": "https://www.uniprot.org/uniprotkb/F1ME99/entry", "sequence": { "sequence": "MTTAAERKYLNIRKRLDQLGYRQTLTVDCIPLVEKLFSDLVHTTESLRKSKLSAVKAEKESANFDFVLEPYKLENARLSKENNELYLELMKLREQSGQHIKELKTTLKKCARETADLKFLNNQYVHKLKLMEKESKAKNEKIQQLQEKNLQAVVQTPGGKKRNIAFRRQRMQIDEPVPPSEISSYPVPQPDDPYIADLLHVADNRIQELQQEVCQLQEKLAMMESELRDYNKQIELREREIERLSIALDGGRSSDILSLETRNKANEKLIAHLNIQVDFLQQANKDLEKHIQELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLKTADKELEEAKKEIKKKLSEMRNLEETIGKLQLELSLCHKEKERLSDELLIKSDLETVVHQLEQEKQRLNKKIESFAVTERELTVEIERMRLEHGIKRRDKSPSRLDTFLKGIEDERDFYKKELEKLQHIIQRRSCSRSHSTCEKTPVFKTLEKGDYDSDIHLITRERDELQRMLERFEKHMVDIQSNVKLLTAERDKLSVLYNEHLQEMSVFGKSELEKTIEHLTCVNHQLENEKCELKSKIFIMKETMESLEKKAKFQAQKLSHVAGDSSHQKTEMNSLRLVNEQLQRSLEDYQHRLNMKRSELESAQAQVKILEEKIGKLHLRMTSQNEEAHVMKKTIGVIDKEKDILQETVDEKTEKIANLHENLASKEKTITQMKITVSEYESSLNHLKETLINRDREISSLRRQLDAAHKELDEVGRSKEMSFKENRRLQDDLATMARENQQISLELEAAVQEKEEMKSRVHNYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHMNAHHAYESQISSMAKAISRLEEELRHQEDEKAAVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVTMELENIKSESELLKKQLLSERHTIKNLESLLATNRDKEFHSHLTSHEKDTEIQILKEKLTLSESKLNSQSRENTMLRAKMAQLQTDLDVLKRQISTERYERERAIQEMRRHGLRTPPLSSTMRSPLHSPEHIN", "length": 1088, "header": "tr|F1ME99-1|F1ME99_BOVIN Isoform 1 of Centrosomal protein 135 OS=Bos taurus OX=9913 GN=CEP135 PE=3 SV=4 CANONICAL=F1ME99-1" }, "locus": { "chromosome": "6", "start_pos": 71427244, "end_pos": 71360600, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012468.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012468.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012468.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012468.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2565942", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "resource": "Reactome", "description": "Regulation of PLK1 Activity at G2/M Transition" }, { "id": "R-BTA-380259", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "resource": "Reactome", "description": "Loss of Nlp from mitotic centrosomes" }, { "id": "R-BTA-380270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "resource": "Reactome", "description": "Recruitment of mitotic centrosome proteins and complexes" }, { "id": "R-BTA-380284", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "resource": "Reactome", "description": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "id": "R-BTA-380320", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "resource": "Reactome", "description": "Recruitment of NuMA to mitotic centrosomes" }, { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-BTA-8854518", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "resource": "Reactome", "description": "AURKA Activation by TPX2" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "F1ME99", "url": "https://www.uniprot.org/uniprotkb/F1ME99" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1ME99", "url": "https://www.uniprot.org/uniprotkb/F1ME99" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of establishment of protein localization", "id": "GO:1904951", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904951", "evidence": [ { "database": "UniProtKB", "id": "F1ME99", "url": "https://www.uniprot.org/uniprotkb/F1ME99" } ], "pmid": "" }, { "name": "positive regulation of non-motile cilium assembly", "id": "GO:1902857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902857", "evidence": [ { "database": "UniProtKB", "id": "F1ME99", "url": "https://www.uniprot.org/uniprotkb/F1ME99" } ], "pmid": "" }, { "name": "centriole-centriole cohesion", "id": "GO:0010457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010457", "evidence": [ { "database": "UniProtKB", "id": "F1ME99", "url": "https://www.uniprot.org/uniprotkb/F1ME99" } ], "pmid": "" }, { "name": "centriole replication", "id": "GO:0007099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007099", "evidence": [ { "database": "UniProtKB", "id": "F1ME99", "url": "https://www.uniprot.org/uniprotkb/F1ME99" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "F1ME99", "url": "https://www.uniprot.org/uniprotkb/F1ME99" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1ME99", "url": "https://www.uniprot.org/uniprotkb/F1ME99" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1ME99-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1088, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1ME99-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ME99" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 307, "end_pos": 309 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MER8-1", "uniprot_ac": "F1MER8", "uniprot_id": "F1MER8_BOVIN", "mass": { "chemical_mass": 92796.0, "monoisotopic_mass": 92796.0 }, "refseq": { "ac": "XP_002689233", "name": "follistatin-related protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689233" }, "gene_names": [ { "name": "FSTL4", "type": "recommended", "evidence": [ { "id": "F1MER8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MER8" } ] }, { "name": "FSTL4", "type": "synonym", "evidence": [ { "id": "XP_002689233", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689233" } ] } ], "protein_names": [ { "name": "Follistatin like 4", 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"https://www.ensembl.org/id/ENSBTAG00000017105" } ] } } ], "crossref": [ { "id": "F1MER8", "url": "https://alphafold.ebi.ac.uk/entry/F1MER8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017105", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017105", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00104", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00104", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05736", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05736", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540809", "url": "https://www.ncbi.nlm.nih.gov/gene/540809", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050653", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050653", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:540809", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540809", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RYLPVCG", "url": "https://omabrowser.org/oma/group/RYLPVCG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MER8", "url": "https://www.orthodb.org/?gene=F1MER8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10913", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10913", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10913:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10913:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07648", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07648", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002689233", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689233", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TBR7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MER8", "url": "https://www.uniprot.org/uniprotkb/F1MER8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MER8-1", "url": "https://www.uniprot.org/uniprotkb/F1MER8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPGGFWLHLTLLGASLPAALGWMNPGASGGWNVGVGESPAEESRSLDVRRREGLSSHDELPASCGKKLCGRGSRCMLNRETGEPECRCLEACRPSYVPVCGSDGRVYENHCELHRAACLLGKKIVMVRNKDCFLKGDPCTVADYARLKKVLLALQSRLQPLHEGDSRQDPASQKRLLVESLFKDFDADGDGHLGTSELAQHMLKEQDLEEDFLGCSPGDLLRFDDYNKDGLLTLHEFYTAFQVVQLSLAPEERVSVATVTVGLSTVLTCAIRGDLRPPIVWKRNGLALNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPETQAQEPGVAASLRCHAEGIPMPRITWLKNGMDVSTQMSKQLSLLANGSELHIGSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVLHPVDCEIQRHLKPTEKIFMSYEEICPQKDGDATQPCQWASAVNVRHHYIYVAQPTLSRVLVVDVQAQKVLQSIGVDPLPAKLSYDKSHDQVWVLSWGNVHKSQPSLQVITEASTGQGQRLIRTPFAGVDDFFIPPTNLIINHIRFGFIFNKSDPAIHKVDLETLMPLKTIKLQSHGCLPQAMAHTHLGGYFFVQCRQDSSSEASPQLLIDSVTDTVVGPNGQVTGTPHTSPDGRFVVSAAPGSPQLHVQEISLRGEIRTLYNLKVSPGVSDVAFQRSFTQGDQYHVYATLETEPDLLFLELSTGKMGVLKGLKEPAPAGPARAWAGPRRIVRDSGLFGQHLLTPARESLFLINGRQNALRCEVAGVKGGTTVVWVGEV", "length": 843, "header": "tr|F1MER8-1|F1MER8_BOVIN Isoform 1 of Follistatin like 4 OS=Bos taurus OX=9913 GN=FSTL4 PE=4 SV=2 CANONICAL=F1MER8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TBR7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBR7/entry", "sequence": { "sequence": "MVTKQETLPAPGLSSHDELPASCGKKLCGRGSRCMLNRETGEPECRCLEACRPSYVPVCGSDGRVYENHCELHRAACLLGKKIVMVRNKDCFLKGDPCTVADYARLKKVLLALQSRLQPLHEGDSRQDPASQKRLLVESLFKDFDADGDGHLGTSELAQHMLKEQDLEEDFLGCSPGDLLRFDDYNKDGLLTLHEFYTAFQVVQLSLAPEERVSVATVTVGLSTVLTCAIRGDLRPPIVWKRNGLALNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPETQAQEPGVAASLRCHAEGIPMPRITWLKNGMDVSTQMSKQLSLLANGSELHIGSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVLHPVDCEIQRHLKPTEKIFMSYEEICPQKDGDATQPCQWASAVNVRHHYIYVAQPTLSRVLVVDVQAQKVLQSIGVDPLPAKLSYDKSHDQVWVLSWGNVHKSQPSLQVITEASTGQGQRLIRTPFAGVDDFFIPPTNLIINHIRFGFIFNKSDPAIHKVDLETLMPLKTIKLQSHGCLPQAMAHTHLGGYFFVQCRQDSSSEASPQLLIDSVTDTVVGPNGQVTGTPHTSPDGRFVVSAAPGSPQLHVQEISLRGEIRTLYNLKVSPGVSDVAFQRSFTQGDQYHVYATLETEPDLLFLELSTGKMGVLKGLKEPAPAGPARAWAGPRRIVRDSGLFGQHLLTPARESLFLINGRQNALRCEVAGVKGGTTVVWVGEV", "length": 801, "header": "tr|A0AAA9TBR7-1|F1MER8_BOVIN Computationally mapped isoform of Follistatin like 4 OS=Bos taurus OX=9913 GN=FSTL4 PE=4 SV=1 CANONICAL=F1MER8-1" }, "locus": { "chromosome": "7", "start_pos": 45059452, "end_pos": 44828002, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108613.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108613.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094127.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094127.1" } ] } }, { "isoform_ac": "F1MER8-1", "url": "https://www.uniprot.org/uniprotkb/F1MER8/entry", "sequence": { "sequence": "MRPGGFWLHLTLLGASLPAALGWMNPGASGGWNVGVGESPAEESRSLDVRRREGLSSHDELPASCGKKLCGRGSRCMLNRETGEPECRCLEACRPSYVPVCGSDGRVYENHCELHRAACLLGKKIVMVRNKDCFLKGDPCTVADYARLKKVLLALQSRLQPLHEGDSRQDPASQKRLLVESLFKDFDADGDGHLGTSELAQHMLKEQDLEEDFLGCSPGDLLRFDDYNKDGLLTLHEFYTAFQVVQLSLAPEERVSVATVTVGLSTVLTCAIRGDLRPPIVWKRNGLALNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPETQAQEPGVAASLRCHAEGIPMPRITWLKNGMDVSTQMSKQLSLLANGSELHIGSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVLHPVDCEIQRHLKPTEKIFMSYEEICPQKDGDATQPCQWASAVNVRHHYIYVAQPTLSRVLVVDVQAQKVLQSIGVDPLPAKLSYDKSHDQVWVLSWGNVHKSQPSLQVITEASTGQGQRLIRTPFAGVDDFFIPPTNLIINHIRFGFIFNKSDPAIHKVDLETLMPLKTIKLQSHGCLPQAMAHTHLGGYFFVQCRQDSSSEASPQLLIDSVTDTVVGPNGQVTGTPHTSPDGRFVVSAAPGSPQLHVQEISLRGEIRTLYNLKVSPGVSDVAFQRSFTQGDQYHVYATLETEPDLLFLELSTGKMGVLKGLKEPAPAGPARAWAGPRRIVRDSGLFGQHLLTPARESLFLINGRQNALRCEVAGVKGGTTVVWVGEV", "length": 843, "header": "tr|F1MER8-1|F1MER8_BOVIN Isoform 1 of Follistatin like 4 OS=Bos taurus OX=9913 GN=FSTL4 PE=4 SV=2 CANONICAL=F1MER8-1" }, "locus": { "chromosome": "7", "start_pos": 45251352, "end_pos": 44828002, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022743.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022743.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022743.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022743.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 261, "start_aa": "Thr", "end_pos": 261, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr261", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:540809", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540809", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M9PQK6-1", "protein_name": "Follistatin-related protein 4 isoform X1", "gene_name": "fstl4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGCLGLWVLSVLLGASLWLVNGAAAGTTAKELQEGLQDTKHGEPENKVKQNAAVCQRSSCGRGRECVVRAATGRAECVCQERCHSTFVPVCGSDGRFYQNHCELYRSACVRRRTISALHSKHCFLRGDACTMAEYNKLKSILMDMQPQSSTNAENSMAQRRTLVLNMFTYFDRNQDGRVSSEELAEISVKEHLENVLLECSMQDLLRYDDYNNDGHLTLQELYTAFQVIELSLAEDRRLSVSTVTVGLSVVLSCAVQGSLRPPIIWKRNGIILNFLDLEDINDFGDDGSLYITKVTTIHMGNYSCHAHGYEELSQTHLLQVNVPPVILVYPETQAQEPGVAASLRCHADGVPNPKLTWLKNGMDLQPHGSKQISLLANGSELHISSVRYEDTGAYTCIARNEVGVDEDISSLFVEDSARKTLANILWREEGLSVGNMFYVFSNEGITVLQPGNCEIRRHITHTERILGTHEELCPRISGVSSQECVWSSAVSVREKYVFVSQPLLNRLLVMDTQAQRVVQAVETDAMPVKLFYDKSHDQLWVLSWRDLLKSRSTLQVITSASTAAEQRQIIRTQFERVQDFYIPPTNLIITHVRFGFVYLKSEPAVHKVDLETLRVVKSISLQNFSCFPLSMAYTHLSGYYFIECQSEKRPTFQLLIDAVSDAIIGRNPNIHGQPFISPNGRFVVSVDKQRGKLQVQSVSISGELQIHYEADAKMSIADLEFQPSFTDANEFTAVVSSARGSKVLFLDLATGRIKTIGNVKNPVPASSWPWGDANRMVISSGVFGRYLLTSSADSMFILDGKQSAFHCEVSDVKFGNTAVWVGEV", "length": 825 }, "evidence": [ { "id": "F1MER8", "url": "https://omabrowser.org/oma/group/F1MER8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZJ81-1", "protein_name": "Follistatin-like 4", "gene_name": "Fstl4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKPGGFWPHLALLGVSLPAVLGWMDQGASRSPNVVLGQSQTEETRGFEVTRREGLPSPGLSSSCGKKLCSHGSRCLHNRTTGQPLCHCLEVCRPRYMPVCGSDGKLYGNHCELRRAACLLGKRIVSVHSKDCFLKGDMCTVAGYARLKNVLLALQSRRQPLQQETHRQSLASQKRLLVESLFKALDTDGNGRLGSLELAQYVLKEQDMDGSLNRCSPGDLLRFDDYNSDGSLTLGEFYTAFQVIQLSLAPEDKVSVTTVTVGLSTVLTCAIRGDLRPPIIWKRNGLTLSFLGLEDINDFGEDDSLYITKVTTIHMGNYTCHALGHEQLFQTHVLQVNVPPVIRVYPETQAQEPGVAASLRCHAEGIPLPRIVWLKNGMDVSTQMSKQLSLLANGSELHIRSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTRLSVGNMFYVFSDDGIVVIHPVDCEVQRRFKPTEKIFMSYEEICPRVEGDTTQPCQWASAVNVRNRYIYVAQPALNRVLVVDVQAQKVLQSIGVDPLPAKLSYDKSHDQVWVLSWGDMHKSQPSLQVITEASTGQGQHLIRTPFAGVDNFFIPPTNLIINHIRFGFIFNKTDPAVHKVDLETLMSLKTISLQHYGCMPQAMAHTHLGGYFFVQCRQDTPTSTGPQLLIDSVTDSVLGPNSDITGTPHVSPDGRFIVSVSNKGPWLHVQEVTVRGEIQTLYDLKINPGISDLAFQHSFTEGNQYNAYATLDKEPDLLFLELSTGKMGRLKNLKEPSRGPAPPWGGPRRVLRDSGLFGQYLLTAAQDSLFLVNGRQNALRCEVSGIKGAATVVWVGEV", "length": 832 }, "evidence": [ { "id": "F1MER8", "url": "https://omabrowser.org/oma/group/F1MER8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5STE3-1", "protein_name": "Follistatin-related protein 4", "gene_name": "Fstl4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKPGGFWPHLALLGVSLPAVLGWMDQGASRSPNMVPGESQAEETRGFEVTRREGLPSPGLSASCGKKLCSHGSRCLLNRTTGQPSCQCLEVCRPRYMPVCGSDGRLYGNHCELRRAACLLGKRIVSVHSKDCFLKGDMCTMAGYARLKNVLLALQSRRQPLPQGTPRQSLASQKRLLVESLFKDLDADGNGHLGSLELAQYVLKEQDMDGSLNRCSPSDLLRFDDYNSDGSLTLGEFYTAFQVIQLSLAPEDKVSVTTVTVGLSTVLTCAIRGDLRPPIIWKRNGLTLSFLGLEDINDFGEDGSLYITKVTTVHMGNYTCHALGHEQLVQTHVLQVNVPPVIRVYPETQAQEPGVAASLRCHAEGIPLPRIIWLKNGMDVSTQMSKQLSLLANGSELHIGSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFAEDGIVVIHPVDCEVQRRLKPTEKIFMSYEEICPRVEGDATQPCQWASAVNVRNRYIYVAQPALNRVLVVDVQAQKVLQSIGVDPLPVKLSYDKSHDQVWVLSWGDMHKSQPSLQVITEASTGQGQHLIRTPFAGVDNFFIPPTNLIINHIRFGFIFNKTDPAVHKVDLETLMALKTISLRHYGCMPQAMAHTHLGGYFFVQCQQDTPTSTGPQLLIDSVTDSVLGPNSDITGTPHVSPDGRFIVSVSNKGPWLHVQEVTVRGEIQTLYDLKINPGISDLAFQHSFTEGSQYNAYATLDKEPDLLFLELSTGKMGRLKNLKEPPRGPAPTWGGPRRVLRDSGLFGQYLLTPAQESLFLVNGRQNALRCEVSGIKGAATVVWVGEV", "length": 841 }, "evidence": [ { "id": "F1MER8", "url": "https://omabrowser.org/oma/group/F1MER8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6MZW2-1", "protein_name": "Follistatin-related protein 4", "gene_name": "FSTL4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKPGGFWLHLTLLGASLPAALGWMDPGTSRGPDVGVGESQAEEPRSFEVTRREGLSSHNELLASCGKKFCSRGSRCVLSRKTGEPECQCLEACRPSYVPVCGSDGRFYENHCKLHRAACLLGKRITVIHSKDCFLKGDTCTMAGYARLKNVLLALQTRLQPLQEGDSRQDPASQKRLLVESLFRDLDADGNGHLSSSELAQHVLKKQDLDEDLLGCSPGDLLRFDDYNSDSSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVIHPVDCEIQRHLKPTEKIFMSYEEICPQREKNATQPCQWVSAVNVRNRYIYVAQPALSRVLVVDIQAQKVLQSIGVDPLPAKLSYDKSHDQVWVLSWGDVHKSRPSLQVITEASTGQSQHLIRTPFAGVDDFFIPPTNLIINHIRFGFIFNKSDPAVHKVDLETMMPLKTIGLHHHGCVPQAMAHTHLGGYFFIQCRQDSPASAARQLLVDSVTDSVLGPNGDVTGTPHTSPDGRFIVSAAADSPWLHVQEITVRGEIQTLYDLQINSGISDLAFQRSFTESNQYNIYAALHTEPDLLFLELSTGKVGMLKNLKEPPAGPAQPWGGTHRIMRDSGLFGQYLLTPARESLFLINGRQNTLRCEVSGIKGGTTVVWVGEV", "length": 842 }, "evidence": [ { "id": "F1MER8", "url": "https://omabrowser.org/oma/group/F1MER8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MER8", "url": "https://www.uniprot.org/uniprotkb/F1MER8" } ], "pmid": "" }, { "name": "secretory granule", "id": "GO:0030141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030141", "evidence": [ { "database": "UniProtKB", "id": "F1MER8", "url": "https://www.uniprot.org/uniprotkb/F1MER8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MER8", "url": "https://www.uniprot.org/uniprotkb/F1MER8" } ], "pmid": "" }, { "name": "brain-derived neurotrophic factor binding", "id": "GO:0048403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048403", "evidence": [ { "database": "UniProtKB", "id": "F1MER8", "url": "https://www.uniprot.org/uniprotkb/F1MER8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MER8", "url": "https://www.uniprot.org/uniprotkb/F1MER8" } ], "pmid": "" }, { "name": "regulation of BMP signaling pathway", "id": "GO:0030510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030510", "evidence": [ { "database": "UniProtKB", "id": "F1MER8", "url": "https://www.uniprot.org/uniprotkb/F1MER8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" }, { "start_pos": 615, "end_pos": 617, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MER8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 843, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MER8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MER8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MER8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MER8" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 174, "end_pos": 209, "start_aa": "Gln", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MER8", "database": "UniProtKB", "url": 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"tr|A0AAA9TD51-1|F1ME38_BOVIN Computationally mapped isoform of Ubiquitin-like modifier-activating enzyme 6 OS=Bos taurus OX=9913 GN=UBA6 PE=3 SV=1 CANONICAL=F1ME38-1" }, "locus": { "chromosome": "6", "start_pos": 83415764, "end_pos": 83330538, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108645.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108645.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094073.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094073.1" } ] } }, { "isoform_ac": "F1ME38-1", "url": "https://www.uniprot.org/uniprotkb/F1ME38/entry", "sequence": { "sequence": 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"length": 1048, "header": "tr|F1ME38-1|F1ME38_BOVIN Isoform 1 of Ubiquitin-like modifier-activating enzyme 6 OS=Bos taurus OX=9913 GN=UBA6 PE=3 SV=2 CANONICAL=F1ME38-1" }, "locus": { "chromosome": "6", "start_pos": 83411270, "end_pos": 83330538, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008985.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008985.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008985.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008985.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-8866652", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8866652", "resource": "Reactome", "description": "Synthesis of active ubiquitin: roles of E1 and E2 enzymes" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1ME38", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ], "pmid": "" }, { "name": "ubiquitin activating enzyme activity", "id": "GO:0004839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004839", "evidence": [ { "database": "UniProtKB", "id": "F1ME38", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1ME38", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ], "pmid": "" }, { "name": "FAT10 activating enzyme activity", "id": "GO:0019780", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019780", "evidence": [ { "database": "UniProtKB", "id": "F1ME38", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1ME38", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1ME38", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1ME38", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1ME38", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "F1ME38", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "F1ME38", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "F1ME38", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 248, "end_pos": 250, "annotation": "n_glycosylation_sequon" }, { "start_pos": 329, "end_pos": 331, "annotation": "n_glycosylation_sequon" }, { "start_pos": 686, "end_pos": 688, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-8852127", "name": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MHP1-1", "Q17QG5-1", "Q1RMX2-1", "Q2T9X7-1", "Q2TA10-1", "Q1RML1-1", "F1N1X8-1", "F1ME38-1" ], "evidence": [ { "id": "R-BTA-8852127", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8852127" } ] }, { "id": "R-BTA-983152", "name": "Transfer of ubiquitin from E1 to E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A3KMV5-1", "A3KN22-1", "A6H795-1", "Q32PA5-1", "Q3MHP1-1", "A5PJC4-1", "Q0P5K3-1", "Q17QG5-1", "Q1RMW1-1", "Q1RMX2-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32P99-1", "Q1RML1-1", "A0A3Q1MLB6-1", "F1N1X8-1", "F1N3I3-1", "F1ME38-1", "A0A3Q1MAR8-1", "Q32L27-1", "A0ABI0NWC8-1" ], "evidence": [ { "id": "R-BTA-983152", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983152" } ] }, { "id": "R-BTA-983153", "name": "E1 mediated ubiquitin activation", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-29926" ], "output_participant_list": [], "enzyme_list": [ "A3KMV5-1", "F1ME38-1" ], "evidence": [ { "id": "R-BTA-983153", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983153" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29926", "participant_name": "Mg2+ [cytosol]", "crossref": [ { "id": "18420", "database": "ChEBI", "url": "" }, { "id": "C00305", "database": "COMPOUND", "url": "" }, { "id": "11533268", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000547", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MAR8", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] } ] }, { "uniprot_ac": "A0A3Q1MLB6", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] } ] }, { "uniprot_ac": "A0ABI0NWC8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] } ] }, { "uniprot_ac": "A3KMV5", "gene_name": "UBA1", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "A3KMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KMV5" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "A3KMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KMV5" } ] } ] }, { "uniprot_ac": "A3KN22", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] } ] }, { "uniprot_ac": "A5PJC4", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] } ] }, { "uniprot_ac": "A6H795", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] } ] }, { "uniprot_ac": "F1ME38", "gene_name": "UBA6", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "F1ME38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "F1ME38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME38" } ] } ] }, { "uniprot_ac": "F1N1X8", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] } ] }, { "uniprot_ac": "F1N3I3", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] } ] }, { "uniprot_ac": "P61085", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] } ] }, { "uniprot_ac": "Q0P5K3", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] } ] }, { "uniprot_ac": "Q17QG5", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] } ] }, { "uniprot_ac": "Q1RML1", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] } ] }, { "uniprot_ac": "Q1RMW1", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] } ] }, { "uniprot_ac": "Q1RMX2", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] } ] }, { "uniprot_ac": "Q2T9X7", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] } ] }, { "uniprot_ac": "Q2TA03", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] } ] }, { "uniprot_ac": "Q32L27", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] } ] }, { "uniprot_ac": "Q32LN1", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] } ] }, { "uniprot_ac": "Q32P99", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] } ] }, { "uniprot_ac": "Q32PA5", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] } ] }, { "uniprot_ac": "Q3MHP1", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1ME38-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1048, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1ME38-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ME38" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1ME38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME38" }, { "id": "SM00985", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00985" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-activating enzyme E1 C-terminal", "eco_id": "ECO_0000259", "start_pos": 912, "end_pos": 1034, "start_aa": "Tyr", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.2.1.45", "ec_name": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "6.2.1.45", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.2.1.45" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 134, "end_pos": 136 }, { "start_pos": 19, "end_pos": 21 }, { "start_pos": 248, "end_pos": 250 }, { "start_pos": 329, "end_pos": 331 }, { "start_pos": 686, "end_pos": 688 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPP1-1", "uniprot_ac": "E1BPP1", "uniprot_id": "E1BPP1_BOVIN", "mass": { "chemical_mass": 103612.0, "monoisotopic_mass": 103612.0 }, "refseq": {}, "gene_names": [ { "name": "TTK", "type": "recommended", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ], "protein_names": [ { "name": "Dual specificity protein kinase TTK", "type": "recommended", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1/entry#names_and_taxonomy" } ] }, { "name": "2.7.12.1", "type": "synonym", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates. Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment.", "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1#function" }, { "database": "UniProtKB", "id": "ARBA00093413", "url": "https://www.uniprot.org/uniprotkb/ARBA00093413#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTK", "url": "https://www.uniprot.org/uniprotkb/E1BPP1", "locus": { "chromosome": "9", "start_pos": 19745540, "end_pos": 19702111, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005456", "url": "https://www.ensembl.org/id/ENSBTAG00000005456" } ] } } ], "crossref": [ { "id": "E1BPP1", "url": "https://alphafold.ebi.ac.uk/entry/E1BPP1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005456", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005456", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14131", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14131", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027084", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027084", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BPP1", "url": "https://www.orthodb.org/?gene=E1BPP1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22974", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22974", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22974:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22974:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "10596", "url": "https://www.rhea-db.org/rhea/10596", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TE04", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TE04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPP1-1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSRGQHWPIGDRVGSGGEIQTCVWRGAGVSIFSSQLRFSVERPTLAANGGAEAAGVCGRLSRAARAEMEAEELSGKELTIDSIMNKMRDIKNKFKNEDLTDELSLTKASTDTTDNSGTVNQIMMMANNPEDWLNLLLKLEKNSVPLNDALLNKLIGRYNQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNFKKSKQLLHKAVECGAAPLEMLEIAIQNLNLQKKQLLSEEERKSLSASTVSSAQEPFPSTLGHLQNRNISCDSKGQTTKARFLYGENIPPQDTEIGYRNPLKQTSKAKRSCPFGRVPVNLLSSPDSHEKMDVSVAPHFTKRHISGSECRDTITPGCKSSGNDSSELRHLKSVQNVRSKEPVISDEKSSELITDSVTLKNKSESSFLTKLEETKEHQELKVPESELKQRQSKRKSECANQNAAAFSSQWQIPEVIPKIDTEKQTTFEQPAFSVSKQSPPISTPKWIDPKSICKTPSNSALDDYMSCFRTPVVKNDFPPACQLSTPYSQLAYFQQQQQQIPVTPLQNLQISASSSTNECISVKGKIYSILKQIGSGGSSKVFQVLNEKKQIHAIKYVNLEEADSQTVESYQNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNTWLKKKKSISPWERKSYWKNMLEAVYTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTVNYMPPEAIKDMSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQHIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLIRDPKKRISIPELLAHPYVQLQTHPGNQTAKETAEEMKYVLGQLVGLNSPNSILKAAKTLYEQYSGGESHGSSSSSKTLAKKWQRK", "length": 923, "header": "tr|E1BPP1-1|E1BPP1_BOVIN Isoform 1 of Dual specificity protein kinase TTK OS=Bos taurus OX=9913 GN=TTK PE=4 SV=4 CANONICAL=E1BPP1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TE04-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TE04/entry", "sequence": { "sequence": "MEAEELSGKELTIDSIMNKMRDIKNKFKNEDLTDELSLTKASTDTTGCELHEGMVFICSIYRTKNGSWQVITQELLTK", "length": 78, "header": "tr|A0AAA9TE04-1|E1BPP1_BOVIN Computationally mapped isoform of Dual specificity protein kinase TTK OS=Bos taurus OX=9913 GN=TTK PE=4 SV=1 CANONICAL=E1BPP1-1" }, "locus": { "chromosome": "9", "start_pos": 19706579, "end_pos": 19703656, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110875.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110875.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094404.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094404.1" } ] } }, { "isoform_ac": "E1BPP1-1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1/entry", "sequence": { "sequence": "MLSRGQHWPIGDRVGSGGEIQTCVWRGAGVSIFSSQLRFSVERPTLAANGGAEAAGVCGRLSRAARAEMEAEELSGKELTIDSIMNKMRDIKNKFKNEDLTDELSLTKASTDTTDNSGTVNQIMMMANNPEDWLNLLLKLEKNSVPLNDALLNKLIGRYNQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNFKKSKQLLHKAVECGAAPLEMLEIAIQNLNLQKKQLLSEEERKSLSASTVSSAQEPFPSTLGHLQNRNISCDSKGQTTKARFLYGENIPPQDTEIGYRNPLKQTSKAKRSCPFGRVPVNLLSSPDSHEKMDVSVAPHFTKRHISGSECRDTITPGCKSSGNDSSELRHLKSVQNVRSKEPVISDEKSSELITDSVTLKNKSESSFLTKLEETKEHQELKVPESELKQRQSKRKSECANQNAAAFSSQWQIPEVIPKIDTEKQTTFEQPAFSVSKQSPPISTPKWIDPKSICKTPSNSALDDYMSCFRTPVVKNDFPPACQLSTPYSQLAYFQQQQQQIPVTPLQNLQISASSSTNECISVKGKIYSILKQIGSGGSSKVFQVLNEKKQIHAIKYVNLEEADSQTVESYQNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNTWLKKKKSISPWERKSYWKNMLEAVYTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTVNYMPPEAIKDMSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQHIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLIRDPKKRISIPELLAHPYVQLQTHPGNQTAKETAEEMKYVLGQLVGLNSPNSILKAAKTLYEQYSGGESHGSSSSSKTLAKKWQRK", "length": 923, "header": "tr|E1BPP1-1|E1BPP1_BOVIN Isoform 1 of Dual specificity protein kinase TTK OS=Bos taurus OX=9913 GN=TTK PE=4 SV=4 CANONICAL=E1BPP1-1" }, "locus": { "chromosome": "9", "start_pos": 19745133, "end_pos": 19702310, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048817.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048817.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045797.5", "url": "https://www.ensembl.org/id/ENSBTAP00000045797.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "meiotic spindle assembly checkpoint signaling", "id": "GO:0033316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033316", "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ], "pmid": "" }, { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ], "pmid": "" }, { "name": "mitotic spindle assembly checkpoint signaling", "id": "GO:0007094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007094", "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ], "pmid": "" }, { "name": "protein localization to kinetochore", "id": "GO:0034501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034501", "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ], "pmid": "" }, { "name": "repair of mitotic kinetochore microtubule attachment defect", "id": "GO:0140273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140273", "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ], "pmid": "" }, { "name": "protein tyrosine kinase activity", "id": "GO:0004713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004713", "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ], "pmid": "" }, { "name": "protein serine/threonine/tyrosine kinase activity", "id": "GO:0004712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004712", "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ], "pmid": "" }, { "name": "kinetochore", "id": "GO:0000776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "evidence": [ { "database": "UniProtKB", "id": "E1BPP1", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 294, "end_pos": 296, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 425, "end_pos": 427, "annotation": "n_glycosylation_sequon" }, { "start_pos": 864, "end_pos": 866, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10596", "name": "", "equation": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MWN2-1", "A0AAF6DMB3-1", "E1BI01-1", "A0AAA9TQL1-1", "F1MQH2-1", "F1N781-1", "F6QXU6-1", "A0A3Q1MKW9-1", "A0A3Q1M0U5-1", "F6S1J8-1", "A5D791-1", "F1N664-1", "E1BMP9-1", "F1MS00-1", "P43481-1", "A0A3Q1LR28-1", "A0A3Q1LVP1-1", "Q06807-1", "A0AAA9TD48-1", "Q5E9X2-1", "Q05688-1", "Q17R13-1", "E1BG90-1", "Q0VBZ0-1", "F1N758-1", "A0A3Q1LTC6-1", "A0A3Q1LNU2-1", "F1N1Q0-1", "A0A3Q1MHB0-1", "A0AAA9SN20-1", "A0AAA9TMY2-1", "A0A3Q1LI98-1", "E1BJ31-1", "A0A3Q1LRR9-1", "F1MX49-1", "A0A3Q1MHG9-1", "A0JNB0-1", "E1BER5-1", "E1BIM8-1", "E1BNE0-1", "A0A3Q1LT44-1", "A0A3Q1MJG0-1", "F1MII5-1", "F1N0D3-1", "F1N261-1", "F1N759-1", "F1N780-1", "F1MC14-1", "F1N3R6-1", "A0ABI0P1V8-1", "A0A3Q1LUE0-1", "F1MFH7-1", "F1MNW2-1", "A0AAA9SPC9-1", "F1N381-1", "F1MS29-1", "G1K218-1", "Q4TVR5-1", "A0AAA9SXH6-1", "E1BJS9-1", "A0AAA9SBR4-1", "F1MKR1-1", "F1MN51-1", "E1BCZ6-1", "E1BEL4-1", "F1MCX4-1", "F1N6J0-1", "Q3SZJ2-1", "Q769I5-1", "Z4YHD9-1", "Q06805-1", "Q3SX21-1", "A0A3Q1MAM7-1", "E1BPB5-1", "A0A3Q1MF99-1", "A0AAA9SA57-1", "A0AAA9TAT1-1", "A0AAA9THG2-1", "F1MC23-1", "A0AAA9SVL9-1", "F1MRU0-1", "A0AAA9T042-1", "E1BKP7-1", "E1BNA8-1", "F1ML02-1", "E1BPI3-1", "A0AAA9SW95-1", "G3X680-1", "A0AAA9TRY4-1", "A0A3Q1MEZ6-1", "E1B9H4-1", "E1B6X6-1", "E1B9Q2-1", "E1BPP1-1", "F1N6H6-1", "A0ABI0NRQ5-1" ], "evidence": [ { "id": "10596", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10596" } ] }, { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", 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"A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LI98", "gene_name": "ABL1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI98" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3Q1LI98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LI98" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LRR9", "gene_name": "TYRO3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRR9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1LRR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRR9" } ] } ] }, { "uniprot_ac": "A0A3Q1LT44", "gene_name": "NTRK2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LT44", "database": 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ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { 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"ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MJG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJG0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MJG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJG0" } ] } ] }, { "uniprot_ac": "A0A3Q1MKC7", "gene_name": "CAMK2A", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MKW9", "gene_name": "ALK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKW9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1MKW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKW9" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MRW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRW3" } ] } ] }, { "uniprot_ac": "A0A3Q1MS69", "gene_name": "NEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MS69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS69" } ] } ] }, { "uniprot_ac": "A0A3Q1MUZ6", "gene_name": "MARK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] } ] }, { "uniprot_ac": "A0A3Q1N860", "gene_name": "RPS6KL1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N860" } ] } ] }, { "uniprot_ac": "A0A3Q1N9F5", "gene_name": "PRKD1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SA57", "gene_name": "ABL2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SA57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA57" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9SA57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SA57" } ] } ] }, { "uniprot_ac": "A0AAA9SBR4", "gene_name": "ERBB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SBR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBR4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SBR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBR4" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SN20", "gene_name": "FLT1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SN20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN20" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SN20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN20" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SPC9", "gene_name": "KDR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SPC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPC9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SPC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPC9" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVL9", "gene_name": "FLT4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9SVL9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVL9" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SW95", "gene_name": "TEC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SW95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW95" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9SW95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SW95" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": 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"ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SXH6", "gene_name": "JAK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9SXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXH6" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TAT1", "gene_name": "FGFR3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TAT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9TAT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAT1" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9THG2", "gene_name": "EPHB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9THG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9THG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG2" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TMY2", "gene_name": "WEE2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMY2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9TMY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMY2" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TQL1", "gene_name": "DDR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TQL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQL1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9TQL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQL1" } ] } ] }, { "uniprot_ac": "A0AAA9TRY4", "gene_name": "CSF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TRY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRY4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAA9TRY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRY4" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMB3", "gene_name": "DDR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AAF6DMB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMB3" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P1V8", "gene_name": "JAK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1V8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0ABI0P1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1V8" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A0JNB0", "gene_name": "FYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0JNB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNB0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0JNB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNB0" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B6X6", "gene_name": "BAZ1B", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B6X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1B6X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B6X6" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9H4", "gene_name": "PKDCC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1B9H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9H4" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BCZ6", "gene_name": "MST1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BCZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCZ6" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEL4", "gene_name": "JAK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEL4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BEL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEL4" } ] } ] }, { "uniprot_ac": "E1BER5", "gene_name": "EPHA4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BER5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BER5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BER5" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BIM8", "gene_name": "SRC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BIM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIM8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BIM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIM8" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJ31", "gene_name": "EPHA2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ31" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BJ31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ31" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BJS9", "gene_name": "EPHA3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BJS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS9" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKP7", "gene_name": "MUSK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKP7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E1BKP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKP7" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BMP9", "gene_name": "ZAP70", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BMP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP9" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNA8", "gene_name": "PTK6", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNA8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BNA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNA8" } ] } ] }, { "uniprot_ac": "E1BNE0", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNE0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BNE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNE0" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPI3", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC14", "gene_name": "NTRK1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC14" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MC14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC14" } ] } ] }, { "uniprot_ac": "F1MC23", "gene_name": "INSRR", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC23" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MC23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC23" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MCX4", "gene_name": "TYK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCX4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1MCX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCX4" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFH7", "gene_name": "EPHA1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFH7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MFH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFH7" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MII5", "gene_name": "EPHB1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MII5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MII5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MII5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MII5" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKR1", "gene_name": "EPHA8", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKR1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKR1" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1ML02", "gene_name": "EPHB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1ML02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML02" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1ML02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML02" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MN51", "gene_name": "FGFR4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN51" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MN51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN51" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MNW2", "gene_name": "FGFR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MNW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNW2" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MQH2", "gene_name": "EPHA6", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQH2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MQH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQH2" } ] } ] }, { "uniprot_ac": "F1MRU0", "gene_name": "FLT3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MRU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRU0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MRU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRU0" } ] } ] }, { "uniprot_ac": "F1MS00", "gene_name": "RET", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MS00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS00" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MS00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS00" } ] } ] }, { "uniprot_ac": "F1MS29", "gene_name": "PTK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MS29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS29" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1MS29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS29" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWN2", "gene_name": "HCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1MWN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN2" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MX49", "gene_name": "PDGFRA", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MX49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX49" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MX49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MX49" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N0D3", "gene_name": "AXL", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N0D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0D3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N0D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0D3" } ] } ] }, { "uniprot_ac": "F1N1Q0", "gene_name": "SRMS", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N1Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Q0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1N1Q0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1Q0" } ] } ] }, { "uniprot_ac": "F1N261", "gene_name": "LYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N261" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1N261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N261" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N381", "gene_name": "MERTK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N381", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N381" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N381", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N381" } ] } ] }, { "uniprot_ac": "F1N3R6", "gene_name": "EPHB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3R6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N3R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3R6" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F1N6H6", "gene_name": "EPHA10", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N6H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6H6" } ] } ] }, { "uniprot_ac": "F1N6J0", "gene_name": "NTRK3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6J0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6J0" } ] } ] }, { "uniprot_ac": "F1N758", "gene_name": "ERBB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N758" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N758" } ] } ] }, { "uniprot_ac": "F1N759", "gene_name": "PDGFRB", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N759" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N759" } ] } ] }, { "uniprot_ac": "F1N780", "gene_name": "EPHA7", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N780" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N780" } ] } ] }, { "uniprot_ac": "F1N781", "gene_name": "EPHA5", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1N781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N781" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QXU6", "gene_name": "LCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QXU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QXU6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6QXU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QXU6" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "F6S1J8", "gene_name": "YES1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6S1J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6S1J8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6S1J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6S1J8" } ] } ] }, { "uniprot_ac": "G1K218", "gene_name": "IGF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "G1K218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G1K218" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "G1K218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G1K218" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G3X680", "gene_name": "BMX", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3X680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X680" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "G3X680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X680" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P43481", "gene_name": "KIT", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "P43481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43481" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P43481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P43481" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q05688", "gene_name": "IGF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q05688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05688" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q05688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05688" } ] } ] }, { "uniprot_ac": "Q06805", "gene_name": "TIE1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q06805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q06805" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q06805" } ] } ] }, { "uniprot_ac": "Q06807", "gene_name": "TEK", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q06807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q06807" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q06807" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VBZ0", "gene_name": "CSK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.4", "activity": "ATP + [a protein]-(L-tyrosine) = ADP + [a protein]-(L-tyrosine)-phosphate. The optimal peptide substrate contains the sequence (relative to the phosphorylated tyrosine): Glu-Glu-Asp/Glu-Ile-Tyr-Phe-Phe-Phe-Phe. Physiological substrates are C-terminal tail of Src-family protein kinases.", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.4", "activity": "", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q769I5", "gene_name": "MET", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q769I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q769I5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q769I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q769I5" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] } ] }, { "uniprot_ac": "Q8MIT6", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q8MIT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8MIT6" } ] } ] }, { "uniprot_ac": "Q95KV0", "gene_name": "IKBKB", "activity": [ { "ec_number": "2.7.11.10", "activity": "L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q95KV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q95KV0" } ] } ] }, { "uniprot_ac": "Q9N0P9", "gene_name": "PIM1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q9N0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9N0P9" } ] } ] }, { "uniprot_ac": "V6F977", "gene_name": "SIK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] }, { "uniprot_ac": "Z4YHD9", "gene_name": "MET", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Z4YHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Z4YHD9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Z4YHD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Z4YHD9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPP1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 923, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPP1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPP1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 591, "end_pos": 856, "start_aa": "Tyr", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.12.1", "ec_name": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.12.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1" }, { "id": "2.7.12.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.12.1" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 174, "end_pos": 176 }, { "start_pos": 294, "end_pos": 296 }, { "start_pos": 387, "end_pos": 389 }, { "start_pos": 425, "end_pos": 427 }, { "start_pos": 864, "end_pos": 866 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPQ0-1", "uniprot_ac": "E1BPQ0", "uniprot_id": "E1BPQ0_BOVIN", "mass": { "chemical_mass": 29227.0, "monoisotopic_mass": 29227.0 }, "refseq": { "ac": "NP_001179896", "name": "UBX domain-containing protein 2A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179896" }, "gene_names": [ { "name": "UBXN2A", "type": "recommended", "evidence": [ { "id": "E1BPQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ] }, { "name": "UBXD4", "type": "synonym", "evidence": [ { "id": "NP_001179896", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179896" } ] }, { "name": "UBXN2A", "type": "synonym", "evidence": [ { "id": "NP_001179896", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179896" } ] } ], "protein_names": [ { "name": "UBX domain-containing protein 2A", "type": "recommended", "evidence": [ { "id": "E1BPQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0/entry#names_and_taxonomy" } ] }, { "name": "UBX domain-containing protein 2A", "type": "synonym", "evidence": [ { "id": "NP_001179896", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179896" } ] } ], "function": [ { "annotation": "Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons. Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation. Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9. Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TNI4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNI4#function" }, { "database": "UniProtKB", "id": "ARBA00053310", "url": "https://www.uniprot.org/uniprotkb/ARBA00053310#function" }, { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0#function" }, { "database": "UniProtKB", "id": "A0AAA9TH23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH23#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UBXN2A", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0", "locus": { "chromosome": "11", "start_pos": 75052239, "end_pos": 75081589, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002033", "url": "https://www.ensembl.org/id/ENSBTAG00000002033" } ] } } ], "crossref": [ { "id": "E1BPQ0", "url": "https://alphafold.ebi.ac.uk/entry/E1BPQ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002033", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002033", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17160", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613578", "url": "https://www.ncbi.nlm.nih.gov/gene/613578", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036241", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036241", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:613578", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613578", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SRCQRSC", "url": "https://omabrowser.org/oma/group/SRCQRSC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPQ0", "url": "https://www.orthodb.org/?gene=E1BPQ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23333:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23333:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00789", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00789", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08059", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179896", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TH23", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH23-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMR9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TMR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMR9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNI4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPQ0-1", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKEVDNLESIKEEWVCETGSDHQPLSDSQQKNCEYFVDSLFEEAQKVGAKCLSPTEQKKQVDVSIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPLELQGVFDKEEVDVKVEDKKNEVCMSTKPVFQPFSGQGHRLGSATPKIVSKAKNIEVENKNKLSAVPLNNLEPITNIQIWLANGKRIVQKFNISHRISHIKDFIEKYQGSQRSPPFSLATALPFLKLLDETLTLEEADLQNAVIIQRLKKTAEPFKELS", "length": 258, "header": "tr|E1BPQ0-1|E1BPQ0_BOVIN Isoform 1 of UBX domain-containing protein 2A OS=Bos taurus OX=9913 GN=UBXN2A PE=4 SV=1 CANONICAL=E1BPQ0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TH23-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH23/entry", "sequence": { "sequence": "MFVWGGPFLVKQKRMKEVDNLESIKEEWVCETGSDHQPLSDSQQKNCEYFVDSLFEEAQKVGAKCLSPTEQKKQVDVSIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPLELQGVFDKEEVDVKVEDKKNEVCMSTKPVFQPFSGQGHRLGSATPKIVSKAKNIEVENKNKLSAVPLNNLEPITNIQIWLANGKRIVQKFNISHRISHIKDFIEKYQGSQRSPPFSLATALPFLKLLDETLTLEEADLQNAVIIQRLKKTAEPFKELS", "length": 272, "header": "tr|A0AAA9TH23-1|E1BPQ0_BOVIN Computationally mapped isoform of UBX domain-containing protein 2A OS=Bos taurus OX=9913 GN=UBXN2A PE=4 SV=1 CANONICAL=E1BPQ0-1" }, "locus": { "chromosome": "11", "start_pos": 75080884, "end_pos": 75053618, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119841.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119841.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097525.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097525.1" } ] } }, { "isoform_ac": "A0AAA9TMR9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMR9/entry", "sequence": { "sequence": "PREARAVPAARPPSSVGPGGGCAPPLRGSSPAAAATAAPERTETEAARRRRGAAPSSGRTGRVCETGSDHQPLSDSQQKNCEYFVDSLFEEAQKVGAKCLSPTEQKKQVDVSIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPLELQGVFDKEEVDVKVEDKKNEVCMSTKPVFQPFSGQGHRLGSATPKIVSKAKNIEVENKNKLSAVPLNNLEPITNIQIWLANGKRIVQKFNISHRQQPTRLPRPWDSPGKNTGVGCHFLLQCMKVKSESEVTQSCPTPSDPMDCSLPGSSVHGIF", "length": 303, "header": "tr|A0AAA9TMR9-1|E1BPQ0_BOVIN Computationally mapped isoform of UBX domain-containing protein 2A OS=Bos taurus OX=9913 GN=UBXN2A PE=4 SV=1 CANONICAL=E1BPQ0-1" }, "locus": { "chromosome": "11", "start_pos": 75081390, "end_pos": 75054402, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092238.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092238.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097644.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097644.1" } ] } }, { "isoform_ac": "A0AAA9TNI4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNI4/entry", "sequence": { "sequence": "PREARAVPAARPPSSVGPGGGCAPPLRGSSPAAAATAAPERTETEAARRRRGAAPSSGRTGRVCETGSDHQPLSDSQQKNCEYFVDSLFEEAQKVGAKCLSPTEQKKQVDVSIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPLELQGVFDKEEVDVKVEDKKNEVCMSTKPVFQPFSGQGHRLGSATPKIVSKAKNIEVENKNKLSAVPLNNLEPITNIQIWLANGKRIVQKFNISHRISHIKDFIEKYQGSQRSPPFSLATALPFLKLLDETLTLEEADLQNAVIIQRLKKTAEPFKELS", "length": 306, "header": "tr|A0AAA9TNI4-1|E1BPQ0_BOVIN Computationally mapped isoform of UBX domain-containing protein 2A OS=Bos taurus OX=9913 GN=UBXN2A PE=4 SV=1 CANONICAL=E1BPQ0-1" }, "locus": { "chromosome": "11", "start_pos": 75081390, "end_pos": 75053618, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119834.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119834.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098586.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098586.1" } ] } }, { "isoform_ac": "E1BPQ0-1", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0/entry", "sequence": { "sequence": "MKEVDNLESIKEEWVCETGSDHQPLSDSQQKNCEYFVDSLFEEAQKVGAKCLSPTEQKKQVDVSIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPLELQGVFDKEEVDVKVEDKKNEVCMSTKPVFQPFSGQGHRLGSATPKIVSKAKNIEVENKNKLSAVPLNNLEPITNIQIWLANGKRIVQKFNISHRISHIKDFIEKYQGSQRSPPFSLATALPFLKLLDETLTLEEADLQNAVIIQRLKKTAEPFKELS", "length": 258, "header": "tr|E1BPQ0-1|E1BPQ0_BOVIN Isoform 1 of UBX domain-containing protein 2A OS=Bos taurus OX=9913 GN=UBXN2A PE=4 SV=1 CANONICAL=E1BPQ0-1" }, "locus": { "chromosome": "11", "start_pos": 75072860, "end_pos": 75053618, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000002634.6", "url": "https://www.ensembl.org/id/ENSBTAT00000002634.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000002634.5", "url": "https://www.ensembl.org/id/ENSBTAP00000002634.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:613578", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:613578", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZRS5-1", "protein_name": "UBX domain-containing protein 2A", "gene_name": "UBXN2A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MKEVDNLESIKEEWVCETGSDHQPLSDNQQINCEYFVDSLFEEAQKVGAKSLSPTEQKKQVDVSIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPLELQGVFDKEEVDVRVEDKKNEVCMSTKPVFQPFSGQGHRLGSATPKIVSKAKSIEVENKNKLSTVPLNNLEPITNVQIWLANGKRIVQKFNISHRISHIKDFIEKYQGPQRSPPFSLATALPFLKLLDETLTLEEADLQNAVIIQRLKKTAEPFKELS", "length": 258 }, "evidence": [ { "id": "E1BPQ0", "url": "https://omabrowser.org/oma/group/E1BPQ0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Y4Y2-1", "protein_name": "UBX domain-containing protein 2A", "gene_name": "UBXN2A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAALHRLLCGRGAALPARPGPAVGVRAARGRACAVERGTVRTWCAAEAAGGAALRGREEPQDENMDNIKTVKEEWMCKSRTGDQILNGTEQNHDYFVDNLFEEAQKIGAICMSPTTVKNQVDVIIKLWKNGFTVNDGELRSYTDVGNQQFLDSVKKGELPFELQKVFEKEEVDVKVEDKKDELYLSSKKPIFHPFSGHGYRLGSATPRIISKAREDHQGAADKRCLPVVPLNDLEPITNIQIWLADGERIIQKFNVSHRISHVRDFITKYQGSEGGVPFMLTTSLPFRELQDETLTLQEAKLQNAVVVQRLRKTTEPFRLLAMKAPDDDCKTAATPNGRLKNEQKNAMKSTSSN", "length": 354 }, "evidence": [ { "id": "E1BPQ0", "url": "https://omabrowser.org/oma/group/E1BPQ0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZID8-1", "protein_name": "UBX domain-containing protein 2A", "gene_name": "Ubxn2a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKEVDNLDSIKEEWVCETGPPDNQPLNDNPQKDCEYFVDSLFEEAEKAGAKCLSPTEQKKQVDVNIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPSELQGVFDKDEVDVKVEDKKNEVCMSTKPVFQPFSGQGHRLGSATPRIVSKAKSIEVDNKSTLSAVSLNNLEPITRIQIWLANGERTVQRFNISHRVSHIKDFIEKYQGTQRSPPFALATALPFLRFLDETLTLEEADLQNAVIIQRLQKTAEPFRKL", "length": 258 }, "evidence": [ { "id": "E1BPQ0", "url": "https://omabrowser.org/oma/group/E1BPQ0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7EY86-1", "protein_name": "UBX domain-containing protein 2A isoform X1", "gene_name": "ubxn2a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MMKNIDSRERHEDDTWCEGAQNEEEEEEEDEEASPIRSSFSVEDLLDEVEKISSVASSGKKVEIVVRLWKNGFTLNDEDLRSYTQEENQEFLEAIKKGELPLELEGRAEDEELEVNVEDMKDEVYVPKKKIFHPFTGRGYRLGSVAPRVVARSRSIHEDCSGPPVPAVELNEDLPVTSLQIWLADGRRLVQRFNLCHRISDVQRFVEQAQITDTPFILTTSLPFRELTDEAQSLEEADLANAVIVQRPVNTHAPFGHS", "length": 258 }, "evidence": [ { "id": "E1BPQ0", "url": "https://omabrowser.org/oma/group/E1BPQ0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3GZP5-1", "protein_name": "UBX domain-containing protein 2A", "gene_name": "Ubxn2a", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKEVDNLDSIKEEWVCETGPPDNQSLNDNQQRDCEYFVDSLFEEAEKVGAKCLSPTEQKKQVDINIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPSELQGIFDKEEVDVKVEDKKNEVCMSTKPVFQPFSGQGHRLGSATPKVISKAKSIEVENKSTLSAVPLNNLEPITRIQIWLANGERTVQRFNVSHRVSHIKDFIEKYQGSQRSPPFALATAFPFLRLLDETLTLEEADLQNAVIIQRLQITSEPFRKL", "length": 258 }, "evidence": [ { "id": "E1BPQ0", "url": "https://omabrowser.org/oma/group/E1BPQ0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P68543-1", "protein_name": "UBX domain-containing protein 2A", "gene_name": "UBXN2A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKDVDNLKSIKEEWVCETGSDNQPLGNNQQSNCEYFVDSLFEEAQKVSSKCVSPAEQKKQVDVNIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPSELQGIFDKEEVDVKVEDKKNEICLSTKPVFQPFSGQGHRLGSATPKIVSKAKNIEVENKNNLSAVPLNNLEPITNIQIWLANGKRIVQKFNITHRVSHIKDFIEKYQGSQRSPPFSLATALPVLRLLDETLTLEEADLQNAVIIQRLQKTASFRELSEH", "length": 259 }, "evidence": [ { "id": "E1BPQ0", "url": "https://omabrowser.org/oma/group/E1BPQ0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99KJ0-1", "protein_name": "UBX domain-containing protein 2A", "gene_name": "Ubxn2a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKEVDNLDSIKEEWACETGPPDSQPLNDNQQKDCEYFVDSLFEEAGKAGAKCLSPTEQKKQVDVNIKLWKNGFTVNDDFRSYSDGASQQFLNSIKKGELPSELWGIFDKEEVDVKVEDKKNEVCMSTKPVFQPFSGQGHRLGSATPRIVSKAKSVEVDNKSTLSAVSLNNLEPITRIQIWLANGERTVQRFNVSHRVSHIKDFIEKYQGSQRSPPFALATALPFLRFLDETLTLEEADLKNAVIIQRLQKTAEPFRKL", "length": 258 }, "evidence": [ { "id": "E1BPQ0", "url": "https://omabrowser.org/oma/group/E1BPQ0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" }, { "name": "perikaryon", "id": "GO:0043204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043204", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" }, { "name": "cis-Golgi network", "id": "GO:0005801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005801", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "regulation of macromolecule metabolic process", "id": "GO:0060255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060255", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" }, { "name": "positive regulation of protein catabolic process", "id": "GO:0045732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045732", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" }, { "name": "negative regulation of ERAD pathway", "id": "GO:1904293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904293", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" }, { "name": "nuclear membrane reassembly", "id": "GO:0031468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031468", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" }, { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" }, { "name": "membrane fusion", "id": "GO:0061025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061025", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" }, { "name": "Golgi organization", "id": "GO:0007030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "acetylcholine receptor binding", "id": "GO:0033130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033130", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" }, { "name": "ubiquitin binding", "id": "GO:0043130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ0", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 191, "end_pos": 193, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPQ0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 258, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPQ0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPQ0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" }, { "id": "PS51399", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51399" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SEP", "eco_id": "ECO_0000259", "start_pos": 60, "end_pos": 124, "start_aa": "Gln", "end_aa": "Met", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BPQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPQ0" }, { "id": "PS50033", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50033" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "UBX", "eco_id": "ECO_0000259", "start_pos": 169, "end_pos": 246, "start_aa": "Asn", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 191, "end_pos": 193 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MFA3-1", "uniprot_ac": "F1MFA3", "uniprot_id": "F1MFA3_BOVIN", "mass": { "chemical_mass": 116294.0, "monoisotopic_mass": 116294.0 }, "refseq": { "ac": "XP_002692237", "name": "presequence protease, mitochondrial isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692237" }, "gene_names": [ { "name": "PITRM1", "type": "recommended", "evidence": [ { "id": "F1MFA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFA3" } ] }, { "name": "PITRM1", "type": "synonym", "evidence": [ { "id": "XP_002692237", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692237" } ] } ], "protein_names": [ { "name": "Presequence protease, mitochondrial", "type": "recommended", "evidence": [ { "id": "F1MFA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFA3/entry#names_and_taxonomy" } ] }, { "name": "Pitrilysin metalloproteinase 1", "type": "synonym", "evidence": [ { "id": "F1MFA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFA3/entry#names_and_taxonomy" } ] }, { "name": "presequence protease, mitochondrial isoform X2", "type": "synonym", "evidence": [ { "id": "XP_002692237", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692237" } ] } ], "function": [ { "annotation": "Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently. It is also able to degrade amyloid-beta protein 42.", "evidence": [ { "database": "UniProtKB", "id": "F1MFA3", "url": "https://www.uniprot.org/uniprotkb/F1MFA3#function" }, { "database": "UniProtKB", "id": "ARBA00060344", "url": "https://www.uniprot.org/uniprotkb/ARBA00060344#function" }, { "database": "UniProtKB", "id": "A0ABI0P2B3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2B3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFA3", "url": "https://www.uniprot.org/uniprotkb/F1MFA3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PITRM1", "url": "https://www.uniprot.org/uniprotkb/F1MFA3", "locus": { "chromosome": "13", "start_pos": 45107760, "end_pos": 45081062, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002685", "url": "https://www.ensembl.org/id/ENSBTAG00000002685" } ] } } ], "crossref": [ { "id": "F1MFA3", "url": "https://alphafold.ebi.ac.uk/entry/F1MFA3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002685", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002685", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "513230", "url": "https://www.ncbi.nlm.nih.gov/gene/513230", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513230", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513230", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NYLYYIR", "url": "https://omabrowser.org/oma/group/NYLYYIR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MFA3", "url": "https://www.orthodb.org/?gene=F1MFA3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43016", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43016", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43016:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43016:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00675", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00675", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08367", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08367", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1268020", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1268020", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002692237", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692237", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9THE0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2B3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2B3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P2B3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2B3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFA3", "url": "https://www.uniprot.org/uniprotkb/F1MFA3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFA3-1", "url": "https://www.uniprot.org/uniprotkb/F1MFA3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWRGGWRARGVLRRLSGGAHLGAWRWGSTKACERALQYRIGERIHGFTVNQVTPVPELSLTAVKLSHDGTGAQYLHLAREDGNNLFSVQFRTTPTDSSGAPHILEHTVLCGSQRYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDAAFFPCLRELDFWQEGWRLEHEDPNDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPDLTWEQLRRFHAMHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQRIEPRTSVPAQKPWDEPREFQITCAPDSLAEGPSGQTTISVSFLLPEITDTFEAFTLSLLSSLLISGPNAPFYKALIESGLGTDFSPDVGYNGCTREAYFSVGLQGIAEKDVQTVRDIVDRTLDDVIEKGFEEDHIEALLHKIEIQMKHQSVSFGLTLTSYIASCWNHDGDPVELLKLGSQVAQFRKCLEENPRFLQEKVKQYFKNNRHKLTLSMKPDDKYSEKQAQMETEKLQQKVTSLSPEEKQQIYEKGLELQAQQSRPPDASCLPALRVSDIEPRIPVTELEVVQAARDTPVQYCAQPTNGVVYFRAFSSLNALPEELRPYVPLFCSVLTKLGCGSLDYRELAQQVELKTGGLAAAPQVLPDDSHLNTYEQGVLFSSFCLDRNLADMMHLWSEILNNPRFEEEEHFRVLVRMAAQELSNGVPDSGHLYASIRAGRTLAPAGDLQETFGGMDQVLLMKRIAEMTDLQPVLGKLLRIWKHLLSCDSLRCSVNATAQQMLQVEGAVEAFLRSLSRTEKEQRSMCPHVVEKPAPKASSGSCLVIRRLVTDPTFEPCQMKTHFLLPFPVNYVAECIRTAPYTAPDHASLKILARLMTAKFLHTEIREKGGAYGGGARLSYGGMFTLYSYRDPRSTETLQSFMKAIDWAKAGRFTQQDIDEAKLSVFSAVDAPVAPSDKGLDHFLYGLSDEMKQVHREQLFTVCHEDLVDVSNRYLGARRSTHGVALLGPDNASIAKDPSWVIRQR", "length": 1031, "header": "tr|F1MFA3-1|F1MFA3_BOVIN Isoform 1 of Presequence protease, mitochondrial OS=Bos taurus OX=9913 GN=PITRM1 PE=3 SV=3 CANONICAL=F1MFA3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9THE0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THE0/entry", "sequence": { "sequence": "MWRGGWRARGVLRRLSGGSAHLGAWRWGSTKACERALQYRIGERIHGFTVNQVTPVPELSLTAVKLSHDGTGAQYLHLAREDGNNLFSVQFRTTPTDSSGAPHILEHTVLCGSQRYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDAAFFPCLRELDFWQEGWRLEHEDPNDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPDLTWEQLRRFHAMHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQRIEPRTSVPAQKPWDEPREFQITCAPDSLAEGPSGQTTISVSFLLPEITDTFEAFTLSLLSSLLISGPNAPFYKALIESGLGTDFSPDVGKGFEEDHIEALLHKIEIQMKHQSVSFGLTLTSYIASCWNHDGDPVELLKLGSQVAQFRKCLEENPRFLQEKVKQYFKNNRHKLTLSMKPDDKYSEKQAQMETEKLQQKVTSLSPEEKQQIYEKGLELQAQQSRPPDASCLPALRVSDIEPRIPVTELEVVQAARDTPVQYCAQPTNGVVYFRAFSSLNALPEELRPYVPLFCSVLTKLGCGSLDYRELAQQVELKTGGLAAAPQVLPDDSHLNTYEQGVLFSSFCLDRNLADMMHLWSEILNNPRFEEEEHFRVLVRMAAQELSNGVPDSGHLYASIRAGRTLAPAGDLQETFGGMDQVLLMKRIAEMTDLQPVLGKLLRIWKHLLSCDSLRCSVNATAQQMLQVEGAVEAFLRSLSRTEKEQRSMCPHVVEKPAPKASSGSCLVIRRLVTDPTFEPCQMKTHFLLPFPVNYVAECIRTAPYTAPDHASLKILARLMTAKFLHTEIREKGGAYGGGARLSYGGMFTLYSYRDPRSTETLQSFMKAIDWAKAGRFTQQDIDEAKLSVFSAVDAPVAPSDKGLDHFLYGLSDEMKQVHREQLFTVCHEDLVDVSNRYLGARRSTHGVALLGPDNASIAKDPSWVIRQR", "length": 994, "header": "tr|A0AAA9THE0-1|F1MFA3_BOVIN Computationally mapped isoform of Presequence protease, mitochondrial OS=Bos taurus OX=9913 GN=PITRM1 PE=3 SV=1 CANONICAL=F1MFA3-1" }, "locus": { "chromosome": "13", "start_pos": 45106998, "end_pos": 45081196, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116048.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116048.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096492.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096492.1" } ] } }, { "isoform_ac": "A0ABI0P2B3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2B3/entry", "sequence": { "sequence": "MLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDAAFFPCLRELDFWQEGWRLEHEDPNDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPDLTWEQLRRFHAMHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQRIEPRTSVPAQKPWDEPREFQITCAPDSLAEGPSGQTTISVSFLLPEITDTFEAFTLSLLSSLLISGPNAPFYKALIESGLGTDFSPDVGYNGCTREAYFSVGLQGIAEKDVQTVRDIVDRTLDDVIEKGFEEDHIEALLHKIEIQMKHQSVSFGLTLTSYIASCWNHDGDPVELLKLGSQVAQFRKCLEENPRFLQEKVKQYFKNNRHKLTLSMKPDDKYSEKQAQMETEKLQQKVTSLSPEEKQQIYEKGLELQAQQSRPPDASCLPALRVSDIEPRIPVTELEVVQAARDTPVQYCAQPTNGVVYFRAFSSLNALPEELRPYVPLFCSVLTKLGCGSLDYRELAQQVELKTGGLAAAPQVLPDDSHLNTYEQGVLFSSFCLDRNLADMMHLWSEILNNPRFEEEEHFRVLVRMAAQELSNGVPDSGHLYASIRAGRTLAPAGDLQETFGGMDQVLLMKRIAEMTDLQPVLGKLLRIWKHLLSCDSLRCSVNATAQQMLQVEGAVEAFLRSLSRTEKEQRSMCPHVVEDPTFEPCQMKTHFLLPFPVNYVAECIRTAPYTAPDHASLKILARLMTAKFLHTEIREKGGAYGGGARLSYGGMFTLYSYRDPRSTETLQSFMKAIDWAKAGRFTQQDIDEAKLSVFSAVDAPVAPSDKGLDHFLYGLSDEMKQVHREQLFTVCHEDLVDVSNRYLGARRSTHGVALLGPDNASIAKDPSWVIQG", "length": 888, "header": "tr|A0ABI0P2B3-1|A0ABI0P2B3_BOVIN Computationally mapped isoform of Presequence protease, mitochondrial OS=Bos taurus OX=9913 GN=PITRM1 PE=3 SV=1 CANONICAL=F1MFA3-1" }, "locus": { "chromosome": "13", "start_pos": 45107027, "end_pos": 45087201, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000150679.1", "url": "https://www.ensembl.org/id/ENSBTAT00000150679.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105193.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105193.1" } ] } }, { "isoform_ac": "F1MFA3-1", "url": "https://www.uniprot.org/uniprotkb/F1MFA3/entry", "sequence": { "sequence": "MWRGGWRARGVLRRLSGGAHLGAWRWGSTKACERALQYRIGERIHGFTVNQVTPVPELSLTAVKLSHDGTGAQYLHLAREDGNNLFSVQFRTTPTDSSGAPHILEHTVLCGSQRYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDAAFFPCLRELDFWQEGWRLEHEDPNDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPDLTWEQLRRFHAMHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQRIEPRTSVPAQKPWDEPREFQITCAPDSLAEGPSGQTTISVSFLLPEITDTFEAFTLSLLSSLLISGPNAPFYKALIESGLGTDFSPDVGYNGCTREAYFSVGLQGIAEKDVQTVRDIVDRTLDDVIEKGFEEDHIEALLHKIEIQMKHQSVSFGLTLTSYIASCWNHDGDPVELLKLGSQVAQFRKCLEENPRFLQEKVKQYFKNNRHKLTLSMKPDDKYSEKQAQMETEKLQQKVTSLSPEEKQQIYEKGLELQAQQSRPPDASCLPALRVSDIEPRIPVTELEVVQAARDTPVQYCAQPTNGVVYFRAFSSLNALPEELRPYVPLFCSVLTKLGCGSLDYRELAQQVELKTGGLAAAPQVLPDDSHLNTYEQGVLFSSFCLDRNLADMMHLWSEILNNPRFEEEEHFRVLVRMAAQELSNGVPDSGHLYASIRAGRTLAPAGDLQETFGGMDQVLLMKRIAEMTDLQPVLGKLLRIWKHLLSCDSLRCSVNATAQQMLQVEGAVEAFLRSLSRTEKEQRSMCPHVVEKPAPKASSGSCLVIRRLVTDPTFEPCQMKTHFLLPFPVNYVAECIRTAPYTAPDHASLKILARLMTAKFLHTEIREKGGAYGGGARLSYGGMFTLYSYRDPRSTETLQSFMKAIDWAKAGRFTQQDIDEAKLSVFSAVDAPVAPSDKGLDHFLYGLSDEMKQVHREQLFTVCHEDLVDVSNRYLGARRSTHGVALLGPDNASIAKDPSWVIRQR", "length": 1031, "header": "tr|F1MFA3-1|F1MFA3_BOVIN Isoform 1 of Presequence protease, mitochondrial OS=Bos taurus OX=9913 GN=PITRM1 PE=3 SV=3 CANONICAL=F1MFA3-1" }, "locus": { "chromosome": "13", "start_pos": 45106998, "end_pos": 45081196, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046212.6", "url": "https://www.ensembl.org/id/ENSBTAT00000046212.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043531.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043531.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513230", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513230", "resource": "KEGG Pathway" }, { "id": "R-BTA-1268020", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1268020", "resource": "Reactome", "description": "Mitochondrial protein import" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K6D5-1", "protein_name": "Presequence protease, mitochondrial", "gene_name": "Pitrm1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWRFSGRRGLCAVQRLSSGVHHKVWREKSDQACDRALQYKVGEKIHGFTVNQVTPVPELFLTAVKLSHDNTGARYLHLAREDNNNLFSVQFRTTPMDSTGVPHVLEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTMYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHEDPSDPQTPLIFKGVVFNEMKGAFTDNERIFSQHLQNKLLPDHTYSVVSGGDPLCIPELTWEQLKQFHTTHYHPSNARFFTYGNFPLEDHLKQIHEEALSKFQKMEESTAVPAQKYWDKPREFHITCGPDSLATDATKQTTVSVSFLLPDITNTFEAFTLNLLSSLLISGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAENDVKTVRELVDRTIEEVIEKGFEDDQIEALLHKIEIQMKHQSASFGMALTSYIASCWNHDGDPVELLQMGSQLTKFRKCLKENPKFLQEKVEQYFKNNPHRLTLSMKPDDRYYEKQTQMETEKLEQKVNSLSQADKKQIYEKGLELQKQQSKHQDASCLPALKVSDIEPTMPFTKFDIALSAGDVPVQYCPQPTNGIVYFRAFSSLNTLPEELRPFVPLFCTVLTKLGCGILNYREQAQQIELKTGGMTVTPHVLPDDSQLDTYEQGVLFSSLCLERNLPDMMHLWSEIFNNPCFEEEEHFKVLVRMSAQELSNGIPDSGHLYAALRAGKTLTPAGDLQETFSGMDQVKVMKRIAEMTDIKPILRKLPRIKKYLLNCDNMRCSVNATPQQMPQAEKEVENFLRNVGRSKKERKPVRPHIVEKPTPSGPSGGAHADGSQIIRKLITDPTFKPCQMKTHFVLPFPVNYVGECVRTVPYADPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKVTHTGIFTLYSYRDPNSIETLQSFGKAIDWAKSGKFTQQDIDEAKLSVFSAVDSPVAPSDKGMDHFLYGLSDEMKQTYREQLFAVTHDKLTSVSHKYLGIGKSTHGLAILGPENSKLAKDPSWIIR", "length": 1035 }, "evidence": [ { "id": "F1MFA3", "url": "https://omabrowser.org/oma/group/F1MFA3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0XRX1-1", "protein_name": "Presequence protease, mitochondrial", "gene_name": "PITRM1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MWSRYRAAAGLLSRGRSLNQKSWRWKSVPANERALLYRVGEQIHGFTVTQVTAVPELFLTAVKLSHDTTGARYLHVAREDSNNLFSLQFRTTPMDSTGVPHILEHTVLCGSQQYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFRNLLSVYLDAAFFPCLRQLDFWQEGWRLEHENPTDPQTPLIFKGVVFNEMKGAFTDNERVFAQHLQNKLLPDHTYGVVSGGHPLSIPDLTWEQLKQFHASHYHPSNSRFFTYGNFPLEHHLKQIHEEALVKFERIESKTDIPKQKIWEKPQEHHITCGLDSFASDPSKQTTVSVSYLLTDITDIFETFTLSLLSSLLVDGPNSPFYKALIESGVGTDFSPDVGFNGSTREAYFSVGLQGIAERDIETVKQIIARTVDEVITKGFEEDRIEALLHKIEIQLKHQSTSFGLALTSYIASCWNQDGDPVELLKIADKVSQFRQCLKENPTFLQEKVKMYFKDNPHRLTLSMSPEEDYYDKQAKLEAEKLKKKVNALSEEEKTQIFEKGLELIDLQSKPQDTSCLPALKVSDIEPKIPFTVLETTFAADEVPVQYCSQPTNGVVYFRAVSSLNTLPEELKPYVPLFCNVITKLGCGALDYREQAQRIELKTGGMSVSPHIIPDDSHLDVYEQGVLFSSLCLDRNLPDMMHLWSEIFNNPRFEEEEHFRVLVKKTAQELSNGIPDCGHLYASIRASKNLTPSGELQEMFSGMDQVKLMKRIAEMPDIKPILRKLPRIKKYLLNSDNIRCSVNAAPQQMSEASKEIEKFLKGITRSKKERKPVRPHVIEKSSEVRPVGSKMLSSLQITRKLINDPTFKPCPMKTHFVLPFPVNYIGECVRTVPYTATDYASLRILARLMTSKFLHREIREKGGAYGGGAKLSHNGIFTFYSYRDPNSLATLKTFEKAVEWAKSGEFTQEDIDEAKLAVFAAVDAPIAPSDKGMDHFLYGISDEMKQSHREQLFAVNKDNLVDVANEYLAVGKSTRGLAVLGPENTDITKDPSWVKR", "length": 1033 }, "evidence": [ { "id": "F1MFA3", "url": "https://omabrowser.org/oma/group/F1MFA3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3GR85-1", "protein_name": "Presequence protease, mitochondrial", "gene_name": "Pitrm1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MWRFRGHRGLCALQRLSCGRVHHRVWREKSDQACERALQYKVGDKIHGFTVKQVTPVPELFLTAVKLSHDNTGARYLHLAREDKNNLFSVQFRTTPMDSTGVPHVLEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTMYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLIFKGVVFNEMKGAFTDNERIFSQHLQNKLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGSFQLEQHLKQIHEEALSKFQKMEQSTAVPAQQHWDKPREFHITCGPDSLATDATKQTTVSVSFLLPDITDTFEAFTLNLLSSLLIAGPNSPFYKALIESGLGTDFSPDVGYNGYTREAFFSVGLQGIAEKDVKTVRELVDRTIEEVIEKGFEDDRIEALLHKIEIQMKHQSTSFGLALTSYIASCWNHDGDPVELLQMGNQLTKFRQCLKENPKFLQEKVEQYFKHNQHKLTLSMKPDDKYYEKQTQMETEKLEQKVNSLSQADKQQIYQKGLELRTQQSKPQDASCLPALKVSDIEPIMPFTKFDIALAAGDIPVQYCPQPTNGVVYFRAFSSLNTLPEELRPYVPLFCNVLTKLGCGILDYREQAQQIELKTGGMTVSPYVLPDDSQLDTYEQGVLFSSLCLERNLPDMMHLWSEIFNNPCFEEEEHFKVLVKMTAQELSNGIPDSGHLYASLRASKTLTPSGDLQETFGGMDQVRLMKRIAEMTDIKPILRKLPRIKKYLLNCDNMRCSVNATPQQMLQAEKEVENFLRNVGRSKKERKPVRPHIVEKPTHNGPDGGAHVNGSQIIRKLITDPTFKPCQMKTHFVLPFPVNYVGECVRTVPYADPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHSGIFTLYSYRDPNSIETLQSFGKAIDWAKSGKFTQQDIDEAKLSVFSAVDSPVAPSDKGMDHFLYGLSDEMKQAYREQLFAVSHDKLTSVSHKYLGIGKSTHGLAILGPENSKIAKDPSWLIR", "length": 1036 }, "evidence": [ { "id": "F1MFA3", "url": "https://omabrowser.org/oma/group/F1MFA3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5JRX3-1", "protein_name": "Presequence protease, mitochondrial", "gene_name": "PITRM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIQ", "length": 1037 }, "evidence": [ { "id": "F1MFA3", "url": "https://omabrowser.org/oma/group/F1MFA3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K411-1", "protein_name": "Presequence protease, mitochondrial", "gene_name": "Pitrm1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWRFSGRRGLCAVQRLSCGRVHHRVWREKSDQACERALQYKVGEKIHGFTVNQVTPVPELFLTAVKLSHDNTGARYLHLAREDKNNLFSVQFRTTPMDSTGVPHVLEHTVLCGSQKYPCRDPFFKMLNRSLSTFMNAMTASDYTIYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQEGWRLEHENPRDPQTPLIFKGVVFNEMKGAFTDNERIFSQHLQNKLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFQLEGHLKQIHEEALSKFQRLEQSTAVPAQPHWDKPREFHITCGPDSLATETAKQTTVSVSFLLPDITDTFEAFTLSLLSSLLIAGPNSPFYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDVKTVRELVDRTIEEVIEKGFEDDRIEALLHKIEIQTKHQSASFGLTLTSYIASCWNHDGDPVELLQIGSQLTRFRKCLKENPKFLQEKVEQYFKNNQHKLTLSMKPDDKYYEKQTQMETEKLEQKVNSLSPADKQQIYEKGLELQTQQSKHQDASCLPALKVSDIEPSMPFTKLDIGLAAGDIPVQYCPQPTNGMVYFRAFSSLNTLPEDLRPIVPLFCSVLTKLGCGILNYREQAQQIELKTGGMSVTPHVLPDDSQLDTYEQGVLFSSLCLERNLPDMMHLWSEIFNNPCFEEEEHFKVLVKMTAQELSNGISDSGHLYAALRASKTLTPSGDLQETFSGMDQVKVMKRIAEMTDIKPILRKLPRIKKYLLNCDNMRCSVNATPQQMPQAEKEVENFLRNVGRSKKERKPVRPHIVEKPTPSGPSGAAHVSGSQIVRKLVTDPTFKPCQMKTHFVLPFPVNYIGECVRTVPYADPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLTHSGIFTLYSYRDPNSIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDSPVAPSDKGMDHFLYGLSDEMKQAYREQLFAVNHDKLTSVSHKYLGIGKSTHGLAILGPENSKIAKDPSWIIK", "length": 1036 }, "evidence": [ { "id": "F1MFA3", "url": "https://omabrowser.org/oma/group/F1MFA3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8MP58-1", "protein_name": "Presequence protease, mitochondrial", "gene_name": "pitrm1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIRLCKNIKTIKPCVNSINNRVTSHGLKVSSSSSSSSSSLFNNNNNNNLDKRSFISSPQTNTTLKPNQTYVFDNQDIFKDIKRGKDRNKLNLKIGDEIHGFKVIKIREVPERQFKTYQFEHIETGAKYLHIDCEDTNNVFSVTFKTIPKDSTGVAHILEHTTLCGSKKYPVRDPFFNMLKRSLNTYMNAWTAPDHTSYPFGTQDPKDYYNLLSVYLDATFFPNLSEQDFRQEGHRLEFEQMENPQSPLKFKGIVFNEMKGALSDPSSFYAEISQQHLYPGTTYSHNSGGEPNDIPSLTYQQLKDFHSNHYHPSNSYFFSYGDLNPINHLKFINDNSLSKFKNNSNNINTTVNKVKRWSESKRIYLKCPPSAMDVNPEKKFKFSISILHKENKDLFESLSLHMLSNLLLRGSNTPMYQALLESGLVLDYSPNTGFDDGLLESSFSVGGIGIKKEDLEKVEKVIIETLEKSSRDGFASDVIESILHQYEFAQKDVSASFGLKLVGSLSSNWIHGGDPVDPLFLNEAIAKLRKELEKGGFFETKIKELLNNPHRLYITMENDENLQKEEQEKELQKLERIKSELTPEQTKEIIEVAKDLQFRQNQIQDVSVLPKINICDIEKQQSKIDHIDTKLSMTNGDGVPLRILDLPTNGISYFRSTIDISSMDPKLKPYVPIFCSLIDEMGAAEFDHKQLDTEINLHIGKFSVSPLITMGHSDLDYTQERIYIKGAALNNNLLKMFSLLQKILLENKWNNPDLLKNLLNQKQASVIEGIPSSGLSYAKILSSSKFSRAAQLSEQWSGLSQVRLINEIVSSNDINSLINKLLAINEFILDRSLMKCLITTEKENISNLENNLSNFLKPFSNKNTPIIVNSLDNANEEITNSSRLNFFPIPATVNYISKTYQAVPYTHVDSAPIQILTKVLSEFLHKEIREKGGAYGGGSSVDSGVISFYSYRDPNLIKTLDAFDQSIQWSLNNKITLENIENAQLSIFSDFDSPESPSNKGVGEWMRDITNEMKQTRRNNLLSITKPKLEEIATKYLFNNQNNYTTVLGSKDNQELNKFTWNNINV", "length": 1066 }, "evidence": [ { "id": "F1MFA3", "url": "https://omabrowser.org/oma/group/F1MFA3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9LJL3-1", "protein_name": "Presequence protease 1, chloroplastic/mitochondrial", "gene_name": "PREP1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MLRTVSCLASRSSSSLFFRFFRQFPRSYMSLTSSTAALRVPSRNLRRISSPSVAGRRLLLRRGLRIPSAAVRSVNGQFSRLSVRAVATQPAPLYPDVGQDEAEKLGFEKVSEEFISECKSKAILFKHKKTGCEVMSVSNEDENKVFGVVFRTPPKDSTGIPHILEHSVLCGSRKYPVKEPFVELLKGSLHTFLNAFTYPDRTCYPVASTNTKDFYNLVDVYLDAVFFPKCVDDAHTFQQEGWHYELNDPSEDISYKGVVFNEMKGVYSQPDNILGRIAQQALSPENTYGVDSGGDPKDIPNLTFEEFKEFHRQYYHPSNARIWFYGDDDPVHRLRVLSEYLDMFEASPSPNSSKIKFQKLFSEPVRLVEKYPAGRDGDLKKKHMLCVNWLLSEKPLDLQTQLALGFLDHLMLGTPASPLRKILLESGLGEALVSSGLSDELLQPQFGIGLKGVSEENVQKVEELIMDTLKKLAEEGFDNDAVEASMNTIEFSLRENNTGSFPRGLSLMLQSISKWIYDMDPFEPLKYTEPLKALKTRIAEEGSKAVFSPLIEKLILNNSHRVTIEMQPDPEKATQEEVEEKNILEKVKAAMTEEDLAELARATEELKLKQETPDPPEALRCVPSLNLGDIPKEPTYVPTEVGDINGVKVLRHDLFTNDIIYTEVVFDIGSLKHELLPLVPLFCQSLLEMGTKDLTFVQLNQLIGRKTGGISVYPLTSSVRGKDEPCSKIIVRGKSMAGRADDLFNLMNCLLQEVQFTDQQRFKQFVSQSRARMENRLRGSGHGIAAARMDAMLNIAGWMSEQMGGLSYLEFLHTLEKKVDEDWEGISSSLEEIRRSLLARNGCIVNMTADGKSLTNVEKSVAKFLDLLPENPSGGLVTWDGRLPLRNEAIVIPTQVNYVGKAGNIYSTGYELDGSAYVISKHISNTWLWDRVRVSGGAYGGFCDFDSHSGVFSYLSYRDPNLLKTLDIYDGTGDFLRGLDVDQETLTKAIIGTIGDVDSYQLPDAKGYSSLLRHLLGVTDEERQRKREEILTTSLKDFKDFAQAIDVVRDKGVAVAVASAEDIDAANNERSNFFEVKKAL", "length": 1080 }, "evidence": [ { "id": "F1MFA3", "url": "https://omabrowser.org/oma/group/F1MFA3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9V9E3-1", "protein_name": "Presequence protease, mitochondrial", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLKGGMLSRWKMWSPQYKILRNHLINFKSVSTYKNISGVNTKQPKSPRQFGCMPHVTKKRKYKYEEGKTYHGFQCERVEHISEFELTSYTFRYERTGTELWHIDRNDSNNVFSINFRTTPFDSTGLPHILEHLSLCGSQKYPVRDPFFKMLNRSVATFMNAMTGPDYTIYPFSTMNEIDFRNLQHIYLDAVFRPNLAYFDFLQEGWRLENKDIFDKQSKLVIKGVVYNEMKGAFSENAQVFSQNLLNNIFPDHTYRHVSGGNPLEIPKLAYNDLVEFHKKYYHPSNARIYSYGLFDASKTLALLDEEYLSDQSWVDNSYSLIRQQERWTQPRLVHISSRLDNMGTTIDRQNQIAIALLMCDATNIQESFELHVLSEVLIRGPNSPFYKNLIEPNFSGGYNQTTGYSSDTKDTTFVVGLQDLRVEDFKKCIEIFDKTIINSMNDGFDSQHVESVLHNLELSLKHQNPNFGNTLLFNSTALWNHDGDVVSNLRVSDMISGLRESISQNKKYFQEKIEKYFANNNHRLTLTMSPDEAYEDKFKQAELELVEQKVKLLDEVKIEKIYERGLILDSYQKAESNTDLLPCLTMNDVRDPPKWPKLFIQNVQNVRTQICKVPTNEITYFKCMFNITGLSHEETQLMPLFCNVISAMGTTNYNYREFDKHILLKTGGFDFKLHLIEDVRDSKSYSLSVMINTHALNNNVPEMFALCQELIKNVRFDDSERLKMLIENYISYISVGVASSGHLYAMLGATSQVCDAGKLKSLLYGVDHIDFMKNFVHSTSTVDICDKLSTIASKVFNKDNMRGAINTTQSYEPSAISNYEKFLESLPTFGKTQTSRNIHYLDPSCQQYVMNIPVNYCAKALFTVPYLHQDHPTLRVLAKLLSAKYLLPVIREKNGAYGAGAKISSDGIFSFYSYRDPNSTKTLNAFDETYKWLRANQNVIDQQSLFESKLGVLQQLDTPIAPGNIGIDYFLYEVSQEDFESYRSRMLSVTIDDLQCAIENYFGKESMHYGKCILGPVNANLELETSHKWIINN", "length": 1034 }, "evidence": [ { "id": "F1MFA3", "url": "https://omabrowser.org/oma/group/F1MFA3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "F1MFA3", "url": "https://www.uniprot.org/uniprotkb/F1MFA3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1MFA3", "url": "https://www.uniprot.org/uniprotkb/F1MFA3" } ], "pmid": "" }, { "name": "proteolysis involved in protein catabolic process", "id": "GO:0051603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051603", "evidence": [ { "database": "UniProtKB", "id": "F1MFA3", "url": "https://www.uniprot.org/uniprotkb/F1MFA3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MFA3", "url": "https://www.uniprot.org/uniprotkb/F1MFA3" } ], "pmid": "" }, { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "F1MFA3", "url": "https://www.uniprot.org/uniprotkb/F1MFA3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MFA3", "url": "https://www.uniprot.org/uniprotkb/F1MFA3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1017, "end_pos": 1019, "annotation": "n_glycosylation_sequon" }, { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 781, "end_pos": 783, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MFA3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1031, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MFA3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MFA3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFA3" }, { "id": "SM01264", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01264" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M16C associated", "eco_id": "ECO_0000259", "start_pos": 502, "end_pos": 750, "start_aa": "Met", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1017, "end_pos": 1019 }, { "start_pos": 126, "end_pos": 128 }, { "start_pos": 781, "end_pos": 783 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MFK3-1", "uniprot_ac": "F1MFK3", "uniprot_id": "F1MFK3_BOVIN", "mass": { "chemical_mass": 74783.0, "monoisotopic_mass": 74783.0 }, "refseq": {}, "gene_names": [ { "name": "PMEL", "type": "recommended", "evidence": [ { "id": "F1MFK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK3" } ] } ], "protein_names": [ { "name": "Premelanosome protein", "type": "synonym", "evidence": [ { "id": "F1MFK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFK3", "url": "https://www.uniprot.org/uniprotkb/F1MFK3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PMEL", "url": "https://www.uniprot.org/uniprotkb/F1MFK3", "locus": { "chromosome": "5", "start_pos": 57353330, "end_pos": 57342864, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004019", "url": "https://www.ensembl.org/id/ENSBTAG00000004019" } ] } } ], "crossref": [ { "id": "F1MFK3", "url": "https://alphafold.ebi.ac.uk/entry/F1MFK3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004019", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004019", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00146", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00146", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000601", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000601", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035986", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035986", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059017", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059017", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MFK3", "url": "https://www.orthodb.org/?gene=F1MFK3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11861", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11861", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11861:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11861:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00801", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00801", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20433", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20433", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26141", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26141", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9THV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TN19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZE8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZE8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFK3", "url": "https://www.uniprot.org/uniprotkb/F1MFK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFK3-1", "url": "https://www.uniprot.org/uniprotkb/F1MFK3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRSTFMSGRGMPVSAEASMNFLRSWCRNSKTRGLSNAPESLVAGRKNRMDLVLRKYLLHVALMGVLLAVGTTEGPRDRDWLGVSRQLRIKAWNRQLYPEWTESQGPDCWRGGHISLKVSNDGPTLIGANASFSIALHFPKSQKVLPDGQVIWANNTIINGSQVWGGQLVYPQEPDDTCIFPDGEPCPSGPLSQKRCFVYVWKTWDQYWQVLGGPVSGLSIGTDKAMLGTYNMEVTVYHRRGSQSYVPLAHSSSAFTITDQVPFSVSVSQLQALDGRNKRFLRKQPLTFALQLHDPSGYLAGADLSYTWDFGDSTGTLISRALTVTHTYLESGPVTAQVVLQAAIPLTSCGSSPVPGTTDRHVTTAEAPGTTAGQVPTTEVMGTTPGQVPTAEAPGTTVGWVPTTEDVGTTPEQVATSKVLSTTPVEMPTAKATGRTPEVSTTEPSGTTVTQGTTPELVETTAGEVSTPEPAGSNTSSFMPTEGTAGSLSPLPDDTATLVLEKRQAPLDCVLYRYGSFSLTLDIVQGIESAEILQAVSSSEGDAFELTVSCQGGLPKEACMDISSPGCQLPAQRLCQPVPPSPACQLVLHQVLKGGSGTYCLNVSLADANSLAMVSTQLVMPGQEAGLRQAPLFVGILLVLTALLLASLIYRRRLMKQGSAVPLPQLPHGRTQWLRLPWVFRSCPIGESKPLLSGQQV", "length": 698, "header": "tr|F1MFK3-1|F1MFK3_BOVIN Isoform 1 of Premelanosome protein OS=Bos taurus OX=9913 GN=PMEL PE=3 SV=2 CANONICAL=F1MFK3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9THV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THV0/entry", "sequence": { "sequence": "MDLVLRKYLLHVALMGVLLAVGTTEGGHISLKVSNDGPTLIGANASFSIALHFPKSQKVLPDGQVIWANNTIINGSQVWGGQLVYPQEPDDTCIFPDGEPCPSGPLSQKRCFVYVWKTWDQYWQVLGGPVSGLSIGTDKAMLGTYNMEVTVYHRRGSQSYVPLAHSSSAFTITDQVPFSVSVSQLQALDGRNKRFLRKQPLTFALQLHDPSGYLAGADLSYTWDFGDSTGTLISRALTVTHTYLESGPVTAQVVLQAAIPLTSCGSSPVPGTTDRHVTTAEAPGTTAGQVPTTEVMGTTPGQVPTAEAPGTTVGWVPTTEDVGTTPEQVATSKVLSTTPVEMPTAKATGRTPEVSTTEPSGTTVTQGTTPELVETTAGEVSTPEPAGSNTSSFMPTEGTAGSLSPLPDDTATLVLEKRQAPLDCVLYRYGSFSLTLDIVQGIESAEILQAVSSSEGDAFELTVSCQGGLPKEACMDISSPGCQLPAQRLCQPVPPSPACQLVLHQVLKGGSGTYCLNVSLADANSLAMVSTQLVMPGQEAGLRQAPLFVGILLVLTALLLASLIYRRRLMKQGSAVPLPQLPHGRTQWLRLPWVFRSCPIGESKPLLSGQQV", "length": 612, "header": "tr|A0AAA9THV0-1|F1MFK3_BOVIN Computationally mapped isoform of Premelanosome protein OS=Bos taurus OX=9913 GN=PMEL PE=3 SV=1 CANONICAL=F1MFK3-1" }, "locus": { "chromosome": "5", "start_pos": 57353259, "end_pos": 57345252, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117604.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117604.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097835.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097835.1" } ] } }, { "isoform_ac": "A0AAA9TN19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN19/entry", "sequence": { "sequence": "MDLVLRKYLLHVALMGVLLAVGTTEGGHISLKVSNDGPTLIGANASFSIALHFPKSQKVLPDGQVIWANNTIINGSQVWGGQLVYPQEPDDTCIFPDGEPCPSGPLSQKRCFVYVWKTWEGIESAEILQAVSSSEGDAFELTVSCQGGLPKEACMDISSPGCQLPAQRLCQPVPPSPACQLVLHQVLKGGSGTYCLNVSLADANSLAMVSTQLVMPGQEAGLRQAPLFVGILLVLTALLLASLIYRRRLMKQGSAVPLPQLPHGRTQWLRLPWVFRSCPIGESKPLLSGQQV", "length": 292, "header": "tr|A0AAA9TN19-1|F1MFK3_BOVIN Computationally mapped isoform of Premelanosome protein OS=Bos taurus OX=9913 GN=PMEL PE=3 SV=1 CANONICAL=F1MFK3-1" }, "locus": { "chromosome": "5", "start_pos": 57353259, "end_pos": 57345252, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000115330.1", "url": "https://www.ensembl.org/id/ENSBTAT00000115330.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099907.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099907.1" } ] } }, { "isoform_ac": "A0AAA9TZE8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZE8/entry", "sequence": { "sequence": "MDLVLRKYLLHVALMGVLLAVGTTEGSQVWGGQLVYPQEPDDTCIFPDGEPCPSGPLSQKRCFVYVWKTWDQYWQVLGGPVSGLSIGTDKAMLGTYNMEVTVYHRRGSQSYVPLAHSSSAFTITDQVPFSVSVSQLQALDGRNKRFLRKQPLTFALQLHDPSGYLAGADLSYTWDFGDSTGTLISRALTVTHTYLESGPVTAQVVLQAAIPLTSCGSSPVPGTTDRHVTTAEAPGTTAGQVPTTEVMGTTPGQVPTAEAPGTTVGWVPTTEDVGTTPEQVATSKVLSTTPVEMPTAKATGRTPEVSTTEPSGTTVTQGTTPELVETTAGEVSTPEPAGSNTSSFMPTEGTAGSLSPLPDDTATLVLEKRQAPLDCVLYRYGSFSLTLDIVQGIESAEILQAVSSSEGDAFELTVSCQGGLPKEACMDISSPGCQLPAQRLCQPVPPSPACQLVLHQVLKGGSGTYCLNVSLADANSLAMVSTQLVMPGQEAGLRQAPLFVGILLVLTALLLASLIYRRRLMKQGSAVPLPQLPHGRTQWLRLPWVFRSCPIGESKPLLSGQQV", "length": 563, "header": "tr|A0AAA9TZE8-1|F1MFK3_BOVIN Computationally mapped isoform of Premelanosome protein OS=Bos taurus OX=9913 GN=PMEL PE=3 SV=1 CANONICAL=F1MFK3-1" }, "locus": { "chromosome": "5", "start_pos": 57353259, "end_pos": 57345252, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091166.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091166.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102942.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102942.1" } ] } }, { "isoform_ac": "F1MFK3-1", "url": "https://www.uniprot.org/uniprotkb/F1MFK3/entry", "sequence": { "sequence": "MRRSTFMSGRGMPVSAEASMNFLRSWCRNSKTRGLSNAPESLVAGRKNRMDLVLRKYLLHVALMGVLLAVGTTEGPRDRDWLGVSRQLRIKAWNRQLYPEWTESQGPDCWRGGHISLKVSNDGPTLIGANASFSIALHFPKSQKVLPDGQVIWANNTIINGSQVWGGQLVYPQEPDDTCIFPDGEPCPSGPLSQKRCFVYVWKTWDQYWQVLGGPVSGLSIGTDKAMLGTYNMEVTVYHRRGSQSYVPLAHSSSAFTITDQVPFSVSVSQLQALDGRNKRFLRKQPLTFALQLHDPSGYLAGADLSYTWDFGDSTGTLISRALTVTHTYLESGPVTAQVVLQAAIPLTSCGSSPVPGTTDRHVTTAEAPGTTAGQVPTTEVMGTTPGQVPTAEAPGTTVGWVPTTEDVGTTPEQVATSKVLSTTPVEMPTAKATGRTPEVSTTEPSGTTVTQGTTPELVETTAGEVSTPEPAGSNTSSFMPTEGTAGSLSPLPDDTATLVLEKRQAPLDCVLYRYGSFSLTLDIVQGIESAEILQAVSSSEGDAFELTVSCQGGLPKEACMDISSPGCQLPAQRLCQPVPPSPACQLVLHQVLKGGSGTYCLNVSLADANSLAMVSTQLVMPGQEAGLRQAPLFVGILLVLTALLLASLIYRRRLMKQGSAVPLPQLPHGRTQWLRLPWVFRSCPIGESKPLLSGQQV", "length": 698, "header": "tr|F1MFK3-1|F1MFK3_BOVIN Isoform 1 of Premelanosome protein OS=Bos taurus OX=9913 GN=PMEL PE=3 SV=2 CANONICAL=F1MFK3-1" }, "locus": { "chromosome": "5", "start_pos": 57353259, "end_pos": 57343063, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005250.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005250.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005250.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005250.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MFK3", "url": "https://www.uniprot.org/uniprotkb/F1MFK3" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "F1MFK3", "url": "https://www.uniprot.org/uniprotkb/F1MFK3" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1MFK3", "url": "https://www.uniprot.org/uniprotkb/F1MFK3" } ], "pmid": "" }, { "name": "melanosome", "id": "GO:0042470", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042470", "evidence": [ { "database": "UniProtKB", "id": "F1MFK3", "url": "https://www.uniprot.org/uniprotkb/F1MFK3" } ], "pmid": "" }, { "name": "multivesicular body membrane", "id": "GO:0032585", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032585", "evidence": [ { "database": "UniProtKB", "id": "F1MFK3", "url": "https://www.uniprot.org/uniprotkb/F1MFK3" } ], "pmid": "" }, { "name": "multivesicular body, internal vesicle", "id": "GO:0097487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097487", "evidence": [ { "database": "UniProtKB", "id": "F1MFK3", "url": "https://www.uniprot.org/uniprotkb/F1MFK3" } ], "pmid": "" }, { "name": "melanosome membrane", "id": "GO:0033162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033162", "evidence": [ { "database": "UniProtKB", "id": "F1MFK3", "url": "https://www.uniprot.org/uniprotkb/F1MFK3" } ], "pmid": "" }, { "name": "cis-Golgi network membrane", "id": "GO:0033106", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033106", "evidence": [ { "database": "UniProtKB", "id": "F1MFK3", "url": "https://www.uniprot.org/uniprotkb/F1MFK3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1MFK3", "url": "https://www.uniprot.org/uniprotkb/F1MFK3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "melanosome organization", "id": "GO:0032438", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032438", "evidence": [ { "database": "UniProtKB", "id": "F1MFK3", "url": "https://www.uniprot.org/uniprotkb/F1MFK3" } ], "pmid": "" }, { "name": "positive regulation of melanin biosynthetic process", "id": "GO:0048023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048023", "evidence": [ { "database": "UniProtKB", "id": "F1MFK3", "url": "https://www.uniprot.org/uniprotkb/F1MFK3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 155, "end_pos": 157, "annotation": "n_glycosylation_sequon" }, { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" }, { "start_pos": 475, "end_pos": 477, "annotation": "n_glycosylation_sequon" }, { "start_pos": 603, "end_pos": 605, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MFK3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 698, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MFK3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MFK3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK3" }, { "id": "PS50093", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50093" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PKD", "eco_id": "ECO_0000259", "start_pos": 301, "end_pos": 341, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 130, "end_pos": 132 }, { "start_pos": 155, "end_pos": 157 }, { "start_pos": 160, "end_pos": 162 }, { "start_pos": 475, "end_pos": 477 }, { "start_pos": 603, "end_pos": 605 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. 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} ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "F1MG57", "url": "https://www.uniprot.org/uniprotkb/F1MG57" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MG57-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 125, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MG57-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MG57" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"https://www.genome.jp/dbget-bin/www_bget?bta:539572", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR28535", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28535", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR28535:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28535:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06839", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06839", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10382", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10382", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13086", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13086", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13087", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13087", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010804220", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010804220", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TI11", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TI11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPG1", "url": "https://www.uniprot.org/uniprotkb/E1BPG1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPG1-1", "url": "https://www.uniprot.org/uniprotkb/E1BPG1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTDYFLDLTVISEEIMESQEFIVLYTHQKTKKSKVWQDGILKITHLGNKAILYDDKGGCLESLFLKCLEVKPGDDLESDRYLITVEEVKVAGSTAVKQDVIKEAPALNSKRFMSSGRSLGCQPAGLKRKFTGFRGPHQVPKKMVITENSDPAASLESEKPGPAFLSPLYSTPPLFPTIGKKDASNMPTDSENIVTYKNRERNGIPFSSVISTPSFKINPEVLCEENYVCSPVSSVNKHSDSLLTDESMKRDSLVSHSLGVSQNIRSKAQILALLKSTSTSTSKELNSEIIGHFPQIQPQGSLEIPAEPNCLPEQEEYAEVKSTESLHNQHQSENTMRNKSRWAVYLSSQSSPVHSSTVDGKDIEKKPKTQEGHLNLKDLSMQNRIQFLETCAEKGKRYNEDKSIDDNDQSWDQEGKLEIPSFCENSSLPINCNIVVNDGLLLDSDIQKNNKRSVDQNDQIGKKGSILLREKAQEININGTPEKKYEHLQIESSLSNNSGISDDIFSKSSTNNESLSSIHEPMSDISQPFVEVTFNLNNFETSDTEEESQESSKTSQDSEDSTLVNSSNSRCENISCKEVGSEHLPLLTSTGGKLSETFPMKEILPSQFCDKTCVGYDTETWKAGNTGKERKEVCSDTLSNFDSSLEWTDDRYVENDEGANKSISASFPSKSESMNTNLHIPHLLNIATDQKPENNLFSEQAQTVLGSDLDKTTNQVLPLTSSSGNSIQILNAKQIHSKECTALDKSQTQGSNSLCYPLGKTHISKDTESHISEAEEVGRSRGLSQDHIDVETSGENKQYGNNLRNSSEISGLVNSISLLKSLTEHSTALEGLEVLKKKNTSLKQQGTLQTYEPDSSPEVGKPLTTIVSQAIPKSPHLNQDPHQMIKENEAEPSESRQSLQFIPLGTEEETAFLAVIPKQMERETCNDPKPVEFQGHQVKGSASSAVMVRGHSSQVECSQLSDSTVYGSCTTNTCFLTPELPSTRMQMGFLQFPNEENFTKGDTSFTIEDNLQVRAEFNKDLTKNDSILDFPPKDSDHLYNYLDYNFKSTERTSWEKNKVTSPEQKISTLSPVSTLSFNSRDDDFMLEFSEESLKGQTLPVMKKSSSLENKNLQRLSFEVSRTRAPLVALPPASGPPDSDSCSRMTDRDRQKASGPPIFSLREESAVPSFSFGPKDQSEASFSNESREVTPSEVSLLDNTSTQSKWLKYQNTRQCNLTTPDRVDEKVTDGFFAKAVSGMRFSNTGERENDAVNESSLDSVYLQMMKHMLQQQQQDFSSQDSVCRKKAFSLNINEASKTEEVQNMLGEYACYNCSVTGDLQEVKDSELCFPSGQKVKSACLPQRQIHIPAVFQSPAHYKQVFTSCLTEHLNILLFGLAQRLHKALSKVDISFYTSSNGDKLKNVENNVPSCHHQQPAKLVMVKKEGPNKGRLFYTCDGPKADQCKFFKWFEEMTPGYLTQEKSLPSMVLSDIKSIGFYLRSQKIPLYEECQLFVRKGFDFQRKRYGKLKKFTTVDPEFYNEPKSKLYLKLSRKESSSAYSKDDLWVVSKTLDFELDTFIACSTFFGPSSINEVELLPLKGYFPSNWPTNTVVHALLVCNASTELTTLKNIRDCFNPATLPLTQYLLTMSSSTTTSNKRVNKRKFIPPAFSNINTKFELLSIEATLKLASELIQVHKLNKDQAAALIQIAQMMASRQSVEEAKELAIHTLPITIIHGVFGAGKSYLLAVVILFFVQLFEKCEALTVGNARPWKLLISSSTNVAVDRVLLGLLSLGFEKFVRVGSVRKIAKPVLPYSLYAGSENENEQLKELHALMKEDLTPVERVYVRKSIEQHKLGTNKTLLKQVRVVGVTCAACPFPCMNDLKFPVVVLDECSQMTEPASLLPIARFECEKLILVGDPKQLPPTIQGSDAAHENGLEQTLFDRLCLMGHKPILLRTQYRCHPTISAIANDLFYEGNLMNGISETERSPLLEWLPTLCFYNVKGLEQIERGNSFHNVAEAAFTLKLIQSLIASGIAGSMIGVITLYKSQMYKLCHLLSAMDFDHPNLKAVQVSTVDAFQGAEKEIIILSCVRTRQVGFIDSEKRMNVALTRGRRHLLIVGNLACLRKNRLWGRVIQHCEGREGGLQHASQYEPQLDHLLKDYLEKQAEEKQKKKAEKDKLTDKKSYSQKDMV", "length": 2171, "header": "tr|E1BPG1-1|E1BPG1_BOVIN Isoform 1 of 5'-3' DNA helicase ZGRF1 OS=Bos taurus OX=9913 GN=ZGRF1 PE=4 SV=4 CANONICAL=E1BPG1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TI11-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TI11/entry", "sequence": { "sequence": "MIKENEAEPSESRQSLQFIPLGTEEETAFLAVIPKQMERETCNDPKPVEFQGHQVKGSASSAVMVRGHSSQVECSQLSDSTVYGSCTTNTCFLTPELPSTRMQMGFLQFPNEENFTKGDTSFTIEDNLQVRAEFNKDLTKNDSILDFPPKDSDHLYNYLDYNFKSTERTSWEKNKVTSPEQKISTLSPVSTLSFNSRDDDFMLEFSEESLKGQTLPVMKKSSSLENKNLQRLSFEEVKDSELCFPSGQKVKSACLPQRQIHIPAVFQSPAHYKQVFTSCLTEHLNILLFGLAQRLHKALSKVDISFYTSSNGDKLKNVENNVPSCHHQQPAKLVMVKKEGPNKGRLFYTCDGPKADQCKFFKWFEEMTPGYLTQEKSLPSMVLSDIKSIGFYLRSQKIPLYEECQLFVRKGFDFQRKRYGKLKKFTTVDPEFYNEPKSKLYLKLSRKESSSAYSKDDLWVVSKTLDFELDTFIACSTFFGPSSINEVELLPLKGYFPSNWPTNTVVHALLVCNASTELTTLKNIRDCFNPATLPLTQYLLTMSSSTTTSNKRVNKRKFIPPAFSNINTKFELLSIEATLKLASELIQVHKLNKDQAAALIQIAQMMASRQSVEEAKELAIHTLPITIIHGVFGAGKSYLLAVVILFFVQLFEKCEALTVGNARPWKLLISSSTNVAVDRVLLGLLSLGFEKFVRVGSVRKIAKPVLPYSLYAGSENENEQLKELHALMKEDLTPVERVYVRKSIEQHKLGTNKTLLKQVRVVGVTCAACPFPCMNDLKFPVVVLDECSQMTEPASLLPIARFECEKLILVGDPKQLPPTIQGSDAAHENGLEQTLFDRLCLMGHKPILLRTQYRCHPTISAIANDLFYEGNLMNGISETERSPLLEWLPTLCFYNVKGLEQIERGNSFHNVAEAAFTLKLIQSLIASGIAGSMIGVITLYKSQMYKLCHLLSAMDFDHPNLKAVQVSTVDAFQGAEKEIIILSCVRTRQVGFIDSEKRMNVALTRGRRHLLIVGNLACLRKNRLWGRVIQHCEGREGGLQHASQYEPQLDHLLKDYLEKQAEEKQKKKAEKDKLTDKKSYSQKDMV", "length": 1086, "header": "tr|A0AAA9TI11-1|E1BPG1_BOVIN Computationally mapped isoform of 5'-3' DNA helicase ZGRF1 OS=Bos taurus OX=9913 GN=ZGRF1 PE=4 SV=1 CANONICAL=E1BPG1-1" }, "locus": { "chromosome": "6", "start_pos": 13044712, "end_pos": 13007627, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135077.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135077.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096742.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096742.1" } ] } }, { "isoform_ac": "E1BPG1-1", "url": "https://www.uniprot.org/uniprotkb/E1BPG1/entry", "sequence": { "sequence": "MTTDYFLDLTVISEEIMESQEFIVLYTHQKTKKSKVWQDGILKITHLGNKAILYDDKGGCLESLFLKCLEVKPGDDLESDRYLITVEEVKVAGSTAVKQDVIKEAPALNSKRFMSSGRSLGCQPAGLKRKFTGFRGPHQVPKKMVITENSDPAASLESEKPGPAFLSPLYSTPPLFPTIGKKDASNMPTDSENIVTYKNRERNGIPFSSVISTPSFKINPEVLCEENYVCSPVSSVNKHSDSLLTDESMKRDSLVSHSLGVSQNIRSKAQILALLKSTSTSTSKELNSEIIGHFPQIQPQGSLEIPAEPNCLPEQEEYAEVKSTESLHNQHQSENTMRNKSRWAVYLSSQSSPVHSSTVDGKDIEKKPKTQEGHLNLKDLSMQNRIQFLETCAEKGKRYNEDKSIDDNDQSWDQEGKLEIPSFCENSSLPINCNIVVNDGLLLDSDIQKNNKRSVDQNDQIGKKGSILLREKAQEININGTPEKKYEHLQIESSLSNNSGISDDIFSKSSTNNESLSSIHEPMSDISQPFVEVTFNLNNFETSDTEEESQESSKTSQDSEDSTLVNSSNSRCENISCKEVGSEHLPLLTSTGGKLSETFPMKEILPSQFCDKTCVGYDTETWKAGNTGKERKEVCSDTLSNFDSSLEWTDDRYVENDEGANKSISASFPSKSESMNTNLHIPHLLNIATDQKPENNLFSEQAQTVLGSDLDKTTNQVLPLTSSSGNSIQILNAKQIHSKECTALDKSQTQGSNSLCYPLGKTHISKDTESHISEAEEVGRSRGLSQDHIDVETSGENKQYGNNLRNSSEISGLVNSISLLKSLTEHSTALEGLEVLKKKNTSLKQQGTLQTYEPDSSPEVGKPLTTIVSQAIPKSPHLNQDPHQMIKENEAEPSESRQSLQFIPLGTEEETAFLAVIPKQMERETCNDPKPVEFQGHQVKGSASSAVMVRGHSSQVECSQLSDSTVYGSCTTNTCFLTPELPSTRMQMGFLQFPNEENFTKGDTSFTIEDNLQVRAEFNKDLTKNDSILDFPPKDSDHLYNYLDYNFKSTERTSWEKNKVTSPEQKISTLSPVSTLSFNSRDDDFMLEFSEESLKGQTLPVMKKSSSLENKNLQRLSFEVSRTRAPLVALPPASGPPDSDSCSRMTDRDRQKASGPPIFSLREESAVPSFSFGPKDQSEASFSNESREVTPSEVSLLDNTSTQSKWLKYQNTRQCNLTTPDRVDEKVTDGFFAKAVSGMRFSNTGERENDAVNESSLDSVYLQMMKHMLQQQQQDFSSQDSVCRKKAFSLNINEASKTEEVQNMLGEYACYNCSVTGDLQEVKDSELCFPSGQKVKSACLPQRQIHIPAVFQSPAHYKQVFTSCLTEHLNILLFGLAQRLHKALSKVDISFYTSSNGDKLKNVENNVPSCHHQQPAKLVMVKKEGPNKGRLFYTCDGPKADQCKFFKWFEEMTPGYLTQEKSLPSMVLSDIKSIGFYLRSQKIPLYEECQLFVRKGFDFQRKRYGKLKKFTTVDPEFYNEPKSKLYLKLSRKESSSAYSKDDLWVVSKTLDFELDTFIACSTFFGPSSINEVELLPLKGYFPSNWPTNTVVHALLVCNASTELTTLKNIRDCFNPATLPLTQYLLTMSSSTTTSNKRVNKRKFIPPAFSNINTKFELLSIEATLKLASELIQVHKLNKDQAAALIQIAQMMASRQSVEEAKELAIHTLPITIIHGVFGAGKSYLLAVVILFFVQLFEKCEALTVGNARPWKLLISSSTNVAVDRVLLGLLSLGFEKFVRVGSVRKIAKPVLPYSLYAGSENENEQLKELHALMKEDLTPVERVYVRKSIEQHKLGTNKTLLKQVRVVGVTCAACPFPCMNDLKFPVVVLDECSQMTEPASLLPIARFECEKLILVGDPKQLPPTIQGSDAAHENGLEQTLFDRLCLMGHKPILLRTQYRCHPTISAIANDLFYEGNLMNGISETERSPLLEWLPTLCFYNVKGLEQIERGNSFHNVAEAAFTLKLIQSLIASGIAGSMIGVITLYKSQMYKLCHLLSAMDFDHPNLKAVQVSTVDAFQGAEKEIIILSCVRTRQVGFIDSEKRMNVALTRGRRHLLIVGNLACLRKNRLWGRVIQHCEGREGGLQHASQYEPQLDHLLKDYLEKQAEEKQKKKAEKDKLTDKKSYSQKDMV", "length": 2171, "header": "tr|E1BPG1-1|E1BPG1_BOVIN Isoform 1 of 5'-3' DNA helicase ZGRF1 OS=Bos taurus OX=9913 GN=ZGRF1 PE=4 SV=4 CANONICAL=E1BPG1-1" }, "locus": { "chromosome": "6", "start_pos": 13044712, "end_pos": 12992286, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049376.4", "url": "https://www.ensembl.org/id/ENSBTAT00000049376.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046275.4", "url": "https://www.ensembl.org/id/ENSBTAP00000046275.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:539572", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539572", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "E1BPG1", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BPG1", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "E1BPG1", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ], "pmid": "" }, { "name": "5'-3' DNA helicase activity", "id": "GO:0043139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043139", "evidence": [ { "database": "UniProtKB", "id": "E1BPG1", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BPG1", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "E1BPG1", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "E1BPG1", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ], "pmid": "" }, { "name": "double-strand break repair", "id": "GO:0006302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "database": "UniProtKB", "id": "E1BPG1", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ], "pmid": "" }, { "name": "recombinational repair", "id": "GO:0000725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000725", "evidence": [ { "database": "UniProtKB", "id": "E1BPG1", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1025, "end_pos": 1027, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1184, "end_pos": 1186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1199, "end_pos": 1201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1216, "end_pos": 1218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1253, "end_pos": 1255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1312, "end_pos": 1314, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1598, "end_pos": 1600, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1837, "end_pos": 1839, "annotation": "n_glycosylation_sequon" }, { "start_pos": 339, "end_pos": 341, "annotation": "n_glycosylation_sequon" }, { "start_pos": 426, "end_pos": 428, "annotation": "n_glycosylation_sequon" }, { "start_pos": 479, "end_pos": 481, "annotation": "n_glycosylation_sequon" }, { "start_pos": 497, "end_pos": 499, "annotation": "n_glycosylation_sequon" }, { "start_pos": 513, "end_pos": 515, "annotation": "n_glycosylation_sequon" }, { "start_pos": 566, "end_pos": 568, "annotation": "n_glycosylation_sequon" }, { "start_pos": 574, "end_pos": 576, "annotation": "n_glycosylation_sequon" }, { "start_pos": 661, "end_pos": 663, "annotation": "n_glycosylation_sequon" }, { "start_pos": 806, "end_pos": 808, "annotation": "n_glycosylation_sequon" }, { "start_pos": 840, "end_pos": 842, "annotation": "n_glycosylation_sequon" }, { "start_pos": 998, "end_pos": 1000, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", 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"Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", 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2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "A0A3Q1M493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M493" } ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + 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"activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q28141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28141" } ] } ] }, { "uniprot_ac": "Q29S22", "gene_name": "DDX47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q29S22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29S22" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q2KIZ8", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": 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"A0AAA9TKK4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKK4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFZ4", "url": "https://www.uniprot.org/uniprotkb/F1MFZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFZ4-1", "url": "https://www.uniprot.org/uniprotkb/F1MFZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTKGKIIKCKAAIAWEANKPLSIEEVEVAPPKDHEVRIQIIATALCHSDAHILHPQFEGGVFPVILGHEAAGIVESIGPGVTNFKPGDKVIPLYAPQCGKCKFCLSPRTNFCGKLKHFKNPMGDQKLMEDGTSRFTCKGKPIYHFMGTSTFSQYTVVSDVNLAKLEDDANLERVCLLGCAFSTGYGAVINNAKVTPGSTCAIFGLGGVGLSAVMGCKASGASRIIVVDINSEKFTKAKALGATDCLNPKDLDKPIQEVIVEMTNGGVDFAFECVGGAKIMRAALDSVTVGWGVCTIIGVNVGDNGLNVSAMELLMGRTLTGTSFGGWKGVTSVPKLAADYKNKKLDLDALVTHTLPFDKVNEAFDLMYQGKSIRTVLLF", "length": 380, "header": "tr|F1MFZ4-1|F1MFZ4_BOVIN Isoform 1 of Alcohol dehydrogenase 4 (class II), pi polypeptide OS=Bos taurus OX=9913 GN=ADH4 PE=1 SV=1 CANONICAL=F1MFZ4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TKK4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKK4/entry", "sequence": { "sequence": "MGTKGKIIKCKAAIAWEANKPLSIEEVEVAPPKDHEVRIQIIATALCHSDAHILHPQFEGGVFPVILGHEAAGIVESIGPGVTNFKPGDKVIPLYAPQCGKCKFCLSPRTNFCGKLKHFKNPMGDQKLMEDGTSRFTCKGKPIYHFMGTSTFSQYTVVSDVNLAKLEDDANLERVCLLGCAFSTGYGAVINNAKVTPGSTCAIFGLGGVGLSAVMGCKASGASRIIVVDINSEKFTKAKALGATDCLNPKDLDKPIQEVIVEMTNGGVDFAFECVGGAKIMRAALDSVTVGWGVCTIIGVNVGDNGLNVSAMELLMGRTLTGTSFGGWKGVTSVPKLAADYKNKKLDLDALVTHTLPFDKVNEAFDLMYQGKSLLPTPTSRETTWYQLELRPCQGSSPTRQAPAPAPPPPRSPRRRRTHAPPTSPTLHGCFQLSASR", "length": 437, "header": "tr|A0AAA9TKK4-1|F1MFZ4_BOVIN Computationally mapped isoform of Alcohol dehydrogenase 4 (class II), pi polypeptide OS=Bos taurus OX=9913 GN=ADH4 PE=1 SV=1 CANONICAL=F1MFZ4-1" }, "locus": { "chromosome": "6", "start_pos": 25528875, "end_pos": 25480714, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122254.2", "url": "https://www.ensembl.org/id/ENSBTAT00000122254.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098969.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098969.1" } ] } }, { "isoform_ac": "F1MFZ4-1", "url": "https://www.uniprot.org/uniprotkb/F1MFZ4/entry", "sequence": { "sequence": "MGTKGKIIKCKAAIAWEANKPLSIEEVEVAPPKDHEVRIQIIATALCHSDAHILHPQFEGGVFPVILGHEAAGIVESIGPGVTNFKPGDKVIPLYAPQCGKCKFCLSPRTNFCGKLKHFKNPMGDQKLMEDGTSRFTCKGKPIYHFMGTSTFSQYTVVSDVNLAKLEDDANLERVCLLGCAFSTGYGAVINNAKVTPGSTCAIFGLGGVGLSAVMGCKASGASRIIVVDINSEKFTKAKALGATDCLNPKDLDKPIQEVIVEMTNGGVDFAFECVGGAKIMRAALDSVTVGWGVCTIIGVNVGDNGLNVSAMELLMGRTLTGTSFGGWKGVTSVPKLAADYKNKKLDLDALVTHTLPFDKVNEAFDLMYQGKSIRTVLLF", "length": 380, "header": "tr|F1MFZ4-1|F1MFZ4_BOVIN Isoform 1 of Alcohol dehydrogenase 4 (class II), pi polypeptide OS=Bos taurus OX=9913 GN=ADH4 PE=1 SV=1 CANONICAL=F1MFZ4-1" }, "locus": { "chromosome": "6", "start_pos": 25512508, "end_pos": 25480714, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003769.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003769.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003769.4", "url": "https://www.ensembl.org/id/ENSBTAP00000003769.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 196, "start_aa": "Thr", "end_pos": 196, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr196", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-5365859", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5365859", "resource": "Reactome", "description": "RA biosynthesis pathway" }, { "id": "R-BTA-71384", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71384", "resource": "Reactome", "description": "Ethanol oxidation" } ], "orthologs": [ { "uniprot_canonical_ac": "F1S0Y8-1", "protein_name": "Alcohol dehydrogenase 4 (class II), pi polypeptide", "gene_name": "ADH4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGTKGKVIKCKAAIAWEANKPLNIEEVEVAPPKAHEVRIQIIATALCHTDAHIIHPQYEGAFFPVILGHEAAGIVESVGPGVTNIKPGDKVIPLYLPQCGKCKFCLSPRTNFCGKLKNFRNPIDDQKLMEDETSRFTCKGKPIYHFMGTSTFSQYTVVSDVNLVKIDDDANLERVCLLGCAFSTGYGAVVNTAKVTPGSTCAIFGLGGIGLSAVIGCKAAGASRIIVIDIKNEKFTKAKALGATDCLNPRELDKPIQEVIIEMTNGGVDFAFECVGGADIMRAALDSVTAGWGLCTIIGVNVGDSGLRVSSVELIMGRTLNGTSFGGWKGTDSVPKLAADYKNKKFNLDALVSHTLPFDKINEAFDLMYQGKSIRTVLLF", "length": 380 }, "evidence": [ { "id": "F1MFZ4", "url": "https://omabrowser.org/oma/group/F1MFZ4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P08319-1", "protein_name": "All-trans-retinol dehydrogenase [NAD(+)] ADH4", "gene_name": "ADH4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF", "length": 380 }, "evidence": [ { "id": "F1MFZ4", "url": "https://omabrowser.org/oma/group/F1MFZ4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QYY9-1", "protein_name": "All-trans-retinol dehydrogenase [NAD(+)] ADH4", "gene_name": "Adh4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGTQGKVIKCKAAIAWKTGSPLCIEEIEVSPPKACEVRIQVIATCVCPTDINATDPKKKALFPVVLGHECAGIVESVGPGVTNFKPGDKVIPFFAPQCKRCKLCLSPLTNLCGKLRNFKYPTIDQELMEDRTSRFTCKGRSIYHFMGVSSFSQYTVVSEANLARVDDEANLERVCLIGCGFSSGYGAAINTAKVTPSSTCAVFGLGCVGLSAIIGCKIAGASRIIAIDINGEKFPKAKALGATDCLNPRELDKPVQDVITELTAGGVDYSLDCAGTAQTLKAAVDCTVLGWGSCTVVGAKVDKMTIPTVDVILGRSINGTFFGGWKSVDSVPNLVSDYKNKKFDLDLLVTHALPFESINDAIDLMKEGKSIRTILTF", "length": 377 }, "evidence": [ { "id": "F1MFZ4", "url": "https://omabrowser.org/oma/group/F1MFZ4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ4", "url": "https://www.uniprot.org/uniprotkb/F1MFZ4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ4", "url": "https://www.uniprot.org/uniprotkb/F1MFZ4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ4", "url": "https://www.uniprot.org/uniprotkb/F1MFZ4" } ], "pmid": "" }, { "name": "quinone reductase (NADPH) activity", "id": "GO:0003960", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003960", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ4", "url": "https://www.uniprot.org/uniprotkb/F1MFZ4" } ], "pmid": "" }, { "name": "aldose reductase (NADPH) activity", "id": "GO:0004032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004032", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ4", "url": "https://www.uniprot.org/uniprotkb/F1MFZ4" } ], "pmid": "" }, { "name": "all-trans-retinol dehydrogenase (NAD+) activity", "id": "GO:0004745", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0018479", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ4", "url": "https://www.uniprot.org/uniprotkb/F1MFZ4" } ], "pmid": "" }, { "name": "alcohol dehydrogenase (NAD+) activity", "id": "GO:0004022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004022", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ4", "url": "https://www.uniprot.org/uniprotkb/F1MFZ4" } ], "pmid": "" }, { "name": "S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity", "id": "GO:0051903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051903", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ4", "url": "https://www.uniprot.org/uniprotkb/F1MFZ4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "aldehyde metabolic process", "id": "GO:0006081", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006081", "evidence": [ { "database": "UniProtKB", "id": "F1MFZ4", "url": "https://www.uniprot.org/uniprotkb/F1MFZ4" } ], 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}, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MH63-1", "uniprot_ac": "F1MH63", "uniprot_id": "F1MH63_BOVIN", "mass": { "chemical_mass": 45411.0, "monoisotopic_mass": 45411.0 }, "refseq": {}, "gene_names": [ { "name": "THAP5", "type": "recommended", "evidence": [ { "id": "F1MH63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH63" } ] } ], "protein_names": [ { "name": "THAP domain-containing protein 5", "type": "recommended", "evidence": [ { "id": "F1MH63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH63/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MH63", "url": "https://www.uniprot.org/uniprotkb/F1MH63" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THAP5", "url": "https://www.uniprot.org/uniprotkb/F1MH63", "locus": { "chromosome": "4", "start_pos": 59594296, "end_pos": 59588215, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021869", "url": "https://www.ensembl.org/id/ENSBTAG00000021869" } ] } } ], "crossref": [ { "id": "F1MH63", "url": "https://alphafold.ebi.ac.uk/entry/F1MH63", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000021869", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021869", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR006612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052224", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052224", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NMKRDAW", "url": "https://omabrowser.org/oma/group/NMKRDAW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MH63", "url": "https://www.orthodb.org/?gene=F1MH63", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46927", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46927", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46927:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46927:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05485", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05485", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TRC2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRC2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRC2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH63", "url": "https://www.uniprot.org/uniprotkb/F1MH63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH63-1", "url": "https://www.uniprot.org/uniprotkb/F1MH63-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRYCAAICCKNRRGRNNKERKLSFYPFPLHDKERLEKWLKNMKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAIPTIFALPEDNQEKDPSKKKSQKKKLKSEKEVCLKAKSEESFASNEPKKHPVNTDLLPEHAELLESSALVKPPDPKAESVQNNILTLSLVKQGTRKPESILETSVNQDMGIGGFHTSFENLSSTTITLTTASSEGIQQPLETQEVIEITTNHLANPHFTNNSVEIKSAQENPFILSTVTQTVEELNTDKESVIAIFVPTENSKPAINSFIPAPKETVEMEEDIDIEDSYKDVDYETEVLQIEHSYCRQDVNKEHLWQKVSKLHSKITLLELQEQQTLGRLKSLEALIRQLKQENWLSEENVKIIENHFTTYEVTMI", "length": 395, "header": "tr|F1MH63-1|F1MH63_BOVIN Isoform 1 of THAP domain-containing protein 5 OS=Bos taurus OX=9913 GN=THAP5 PE=4 SV=1 CANONICAL=F1MH63-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TRC2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRC2/entry", "sequence": { "sequence": "MGRFPLHDKERLEKWLKNMKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAIPTIFALPEDNQEKDPSKKKSQKKKLKSEKEVCLKAKSEESFASNEPKKHPVNTDLLPEHAELLESSALVKPPDPKAESVQNNILTLSLVKQGTRKPESILETSVNQDMGIGGFHTSFENLSSTTITLTTASSEGIQQPLETQEVIEITTNHLANPHFTNNSVEIKSAQENPFILSTVTQTVEELNTDKESVIAIFVPTENSKPAINSFIPAPKETVEMEEDIDIEDSYKDVDYETEVLQIEHSYCRQDVNKEHLWQKVSKLHSKITLLELQEQQTLGRLKSLEALIRQLKQENWLSEENVKIIENHFTTYEVTMI", "length": 371, "header": "tr|A0AAA9TRC2-1|F1MH63_BOVIN Computationally mapped isoform of THAP domain-containing protein 5 OS=Bos taurus OX=9913 GN=THAP5 PE=4 SV=1 CANONICAL=F1MH63-1" }, "locus": { "chromosome": "4", "start_pos": 59593285, "end_pos": 59588803, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091959.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091959.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099575.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099575.1" } ] } }, { "isoform_ac": "F1MH63-1", "url": "https://www.uniprot.org/uniprotkb/F1MH63/entry", "sequence": { "sequence": "MPRYCAAICCKNRRGRNNKERKLSFYPFPLHDKERLEKWLKNMKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAIPTIFALPEDNQEKDPSKKKSQKKKLKSEKEVCLKAKSEESFASNEPKKHPVNTDLLPEHAELLESSALVKPPDPKAESVQNNILTLSLVKQGTRKPESILETSVNQDMGIGGFHTSFENLSSTTITLTTASSEGIQQPLETQEVIEITTNHLANPHFTNNSVEIKSAQENPFILSTVTQTVEELNTDKESVIAIFVPTENSKPAINSFIPAPKETVEMEEDIDIEDSYKDVDYETEVLQIEHSYCRQDVNKEHLWQKVSKLHSKITLLELQEQQTLGRLKSLEALIRQLKQENWLSEENVKIIENHFTTYEVTMI", "length": 395, "header": "tr|F1MH63-1|F1MH63_BOVIN Isoform 1 of THAP domain-containing protein 5 OS=Bos taurus OX=9913 GN=THAP5 PE=4 SV=1 CANONICAL=F1MH63-1" }, "locus": { "chromosome": "4", "start_pos": 59593285, "end_pos": 59588241, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029153.5", "url": "https://www.ensembl.org/id/ENSBTAT00000029153.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029153.3", "url": "https://www.ensembl.org/id/ENSBTAP00000029153.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZRG1-1", "protein_name": "THAP domain-containing protein 5", "gene_name": "THAP5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPRYCAAICCKNRRGRNNTDRKLSFYPFPLHDKERLEKWLKNMKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAIPTIFSLPEDNQEKDPSKKKSQKKKSEDEKEVCLKSKSEESFASNEPKKNTVNSNVLPEHAQLLDLSAFVKPPDLKAESVQNNVLTLNLVKQDTRKLESTLETPVNQDIGTHEFHTSFEDLNSTTITLTTSNSEGITKSLETQEVLKITTNHLTNPNFTNNSLEINPAQENPFFFSTITQTVEELNTNKESVIAILIPAENSKPTVNSFMPTPKETMEMEEDIDIEDSYKDADYETEVLQIEHSYCRQDVSKEHLWQKVSKLHSKITHLELQEQQTLGRLKSLEALIRQLKQENWLSEENVKIIGNHFTTNELR", "length": 393 }, "evidence": [ { "id": "F1MH63", "url": "https://omabrowser.org/oma/group/F1MH63/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q7Z6K1-1", "protein_name": "THAP domain-containing protein 5", "gene_name": "THAP5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRYCAAICCKNRRGRNNKDRKLSFYPFPLHDKERLEKWLKNMKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAVPTIFSLPEDNQGKDPSKKKSQKKNLEDEKEVCPKAKSEESFVLNETKKNIVNTDVPHQHPELLHSSSLVKPPAPKTGSIQNNMLTLNLVKQHTGKPESTLETSVNQDTGRGGFHTCFENLNSTTITLTTSNSESIHQSLETQEVLEVTTSHLANPNFTSNSMEIKSAQENPFLFSTINQTVEELNTNKESVIAIFVPAENSKPSVNSFISAQKETTEMEDTDIEDSLYKDVDYGTEVLQIEHSYCRQDINKEHLWQKVSKLHSKITLLELKEQQTLGRLKSLEALIRQLKQENWLSEENVKIIENHFTTYEVTMI", "length": 395 }, "evidence": [ { "id": "F1MH63", "url": "https://omabrowser.org/oma/group/F1MH63/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MH63", "url": "https://www.uniprot.org/uniprotkb/F1MH63" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MH63", "url": "https://www.uniprot.org/uniprotkb/F1MH63" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MH63", "url": "https://www.uniprot.org/uniprotkb/F1MH63" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MH63-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 395, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MH63-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MH63" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MH63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH63" }, { "id": "PS50950", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50950" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "THAP-type", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 84, "start_aa": "Met", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 199, "end_pos": 201 }, { "start_pos": 239, "end_pos": 241 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MCK7-1", "uniprot_ac": "F1MCK7", "uniprot_id": "F1MCK7_BOVIN", "mass": { "chemical_mass": 75592.0, "monoisotopic_mass": 75592.0 }, "refseq": { "ac": "NP_001192527", "name": "WD repeat-containing protein 43", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192527" }, "gene_names": [ { "name": "WDR43", "type": "recommended", "evidence": [ { "id": "F1MCK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ] }, { "name": "WDR43", "type": "synonym", "evidence": [ { "id": "NP_001192527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192527" } ] } ], "protein_names": [ { "name": "WD repeat-containing protein 43", "type": "recommended", "evidence": [ { "id": "F1MCK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCK7/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 43", "type": "synonym", "evidence": [ { "id": "NP_001192527", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192527" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR43", "url": "https://www.uniprot.org/uniprotkb/F1MCK7", "locus": { "chromosome": "11", "start_pos": 70866369, "end_pos": 70905461, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018196", "url": "https://www.ensembl.org/id/ENSBTAG00000018196" } ] } } ], "crossref": [ { "id": "F1MCK7", "url": "https://alphafold.ebi.ac.uk/entry/F1MCK7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018196", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018196", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538915", "url": "https://www.ncbi.nlm.nih.gov/gene/538915", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052414", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052414", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538915", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538915", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PCTALTW", "url": "https://omabrowser.org/oma/group/PCTALTW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MCK7", "url": "https://www.orthodb.org/?gene=F1MCK7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44267", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44267", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44267:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44267:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04003", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04003", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192527", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TUT2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUT2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUT2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCK7-1", "url": "https://www.uniprot.org/uniprotkb/F1MCK7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGGGGVADPLSPAGVPCAFSPQSQAYFALASADGHLRVWETANNRLHQEYVPSAHLSGTCTCLAWAPARLQAKEGPQRKKRKSEAIVTSNQADLLALGTAVGSILLYSTVKGELHSKLINGGHDNRVNCIQWHQDNGCLYSCSDDKHIVEWNTQTCKVKCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLWVLETKEVYRHFTGHATPVSSLTFTTIRPPNEIQPFDGITGLYFLSGAVHDRLLNVWQVRSENKEKNAVMSFTVTDEPVYIDLTLSENKEEPVKLAVVCRDGQVHLFEHILNGYCKKPLTSNCTIQIATPGKGKKSTPKPIPILAAGFCSDKMSLLLVYGNWFQPTIERVALNPKEPHMCLIRDISNCWAPKVETAITKVRTPVMNSEAKVLVPGIPGHHAAVKPPPPQTKEVESKRKLGEKEVSIEERLGALDIASKKEKDNLPQTNSFPVLLTQGLESNDFEILNKVLQTRNLNLIKRTVLRMPLHAVIPLLQELTKRLQGHPNSAILMVQWLKCVLTVHASYLSTLPDLVPQLGTLYQLMESRVKTFQKLSHLHGKLILLITQVTASEKTKETTCPAQKAKLVYEEESSEEESDDEIADKDSDDNWDEDEDEKASEKDEDVDEENEEEEGDDEDKDEENGEDRDVASEKELNGDSDLDPENESEEE", "length": 681, "header": "tr|F1MCK7-1|F1MCK7_BOVIN Isoform 1 of WD repeat-containing protein 43 OS=Bos taurus OX=9913 GN=WDR43 PE=3 SV=2 CANONICAL=F1MCK7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TUT2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUT2/entry", "sequence": { "sequence": "MAAGGGGVADPLSPAGVPCAFSPQSQAYFALASADGHLRVWETANNRLHQEYVPSAHLSGTCTCLAWAPARLQAKEGPQRKKRKSEAIVTSNQADLLALGTAVGSILLYSTVKGELHSKLINGGHDNRVNCIQWHQDNGCLYSCSDDKHIVEWNTQTCKVKCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLWVLETKEVYRHFTGHATPVSSLTFTTIRPPNEIQPFDGITGLYFLSGAVHDRLLNVWQVRSENKEKNAVMSFTVTDEPVYIDLTLSENKEEPVKLAVVCRDGQVHLFEHILNGYCKKPLTSNCTIQIATPGKGKKSTPKPIPILAAGFCSDKMSLLLVYGNWFQPTIERVALNPKEPHMCLIRDISNCWAPKVETAITKVRTPVMNSEAKVLVPGIPGHHAAVKPPPPQTKEVESKRKLGEKEVSIEERLGALDIASKKEKDNLPQTNSFPVLLTQGLESNDFEILNKVLQTRNLNLIKRTVLRMPLHAVIPLLQELTKRLQGHPNSAILMVQWLKCVLTVHASYLSTVTASEKTKETTCPAQKAKLVYEEESSEEESDDEIADKDSDDNWDEDEDEKASEKDEDVDEENEEEEGDDEDKDEENGEDRDVASEKELNGDSDLDPENESEEE", "length": 643, "header": "tr|A0AAA9TUT2-1|F1MCK7_BOVIN Computationally mapped isoform of WD repeat-containing protein 43 OS=Bos taurus OX=9913 GN=WDR43 PE=3 SV=1 CANONICAL=F1MCK7-1" }, "locus": { "chromosome": "11", "start_pos": 70905452, "end_pos": 70867776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088104.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088104.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100340.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100340.1" } ] } }, { "isoform_ac": "F1MCK7-1", "url": "https://www.uniprot.org/uniprotkb/F1MCK7/entry", "sequence": { "sequence": "MAAGGGGVADPLSPAGVPCAFSPQSQAYFALASADGHLRVWETANNRLHQEYVPSAHLSGTCTCLAWAPARLQAKEGPQRKKRKSEAIVTSNQADLLALGTAVGSILLYSTVKGELHSKLINGGHDNRVNCIQWHQDNGCLYSCSDDKHIVEWNTQTCKVKCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLWVLETKEVYRHFTGHATPVSSLTFTTIRPPNEIQPFDGITGLYFLSGAVHDRLLNVWQVRSENKEKNAVMSFTVTDEPVYIDLTLSENKEEPVKLAVVCRDGQVHLFEHILNGYCKKPLTSNCTIQIATPGKGKKSTPKPIPILAAGFCSDKMSLLLVYGNWFQPTIERVALNPKEPHMCLIRDISNCWAPKVETAITKVRTPVMNSEAKVLVPGIPGHHAAVKPPPPQTKEVESKRKLGEKEVSIEERLGALDIASKKEKDNLPQTNSFPVLLTQGLESNDFEILNKVLQTRNLNLIKRTVLRMPLHAVIPLLQELTKRLQGHPNSAILMVQWLKCVLTVHASYLSTLPDLVPQLGTLYQLMESRVKTFQKLSHLHGKLILLITQVTASEKTKETTCPAQKAKLVYEEESSEEESDDEIADKDSDDNWDEDEDEKASEKDEDVDEENEEEEGDDEDKDEENGEDRDVASEKELNGDSDLDPENESEEE", "length": 681, "header": "tr|F1MCK7-1|F1MCK7_BOVIN Isoform 1 of WD repeat-containing protein 43 OS=Bos taurus OX=9913 GN=WDR43 PE=3 SV=2 CANONICAL=F1MCK7-1" }, "locus": { "chromosome": "11", "start_pos": 70905452, "end_pos": 70867776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024220.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024220.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024220.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024220.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538915", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538915", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z9V2-1", "protein_name": "WD repeat domain 43", "gene_name": "WDR43", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAAAACGGEVAARPPLAFSPHDRRFLAVSGSDGRLRVWDTVGSRLQHEYVPSAHLSAACTCLAWAPPGGRPPPDKDGPQRKKRKSEAAEVDKQLDILAIGTAVGSILLYSTVKGELQSKLDGGHDSRINCVRWHQDNCCLYSCSEDKHIVEWNTQTCKVKCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLWDLETKEVYRHFTGHATSVSSLMFTTVKPMNENKPFDGITGLYFLSGAIHDRLLSVWQIRSDRKEKNAVMSFTVTDEPTFIDLTVSELKEEPVKLAVVCKDGQLHLFEHILNGYCKKPLTSNCTIQIATPGNDGDSTPKPVPILAAAFCTDKQSLLLVYGNTLQPIIEKVSLNTSESHICLIRDVQKALALKTDDAVTKVRTPVVNSDTKVLVPGIPGHSAAVKTPSSGKEKKKSKRKPGETEDSIEERLGALDIDVSKVKTPGGLPQTDSFAVLLVQGLESNDEDILNKVLSTRKETLIKNTVARMPIHAVIPLLHELTKRLQGNPYSASQMVRWLKFVFTLHASYLSTLPDLIPQLGMLYQLMESRVKTLQKLSRLHGRLFLLVTQVAASETVQDVTEVNQTAKLVYEDESSEEEGSDDEMIADKDSDENWDEDEEKEEQSDEQDMTVEKEMNGDSDLEPENESEEE", "length": 661 }, "evidence": [ { "id": "F1MCK7", "url": "https://omabrowser.org/oma/group/F1MCK7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A1Z7K2-1", "protein_name": "Small-subunit processome Utp12 domain-containing protein", "gene_name": "CG2396", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSLGKKHVLGFSPNGGQLFASVDESGVLRIWNTETNTLYQEFTPNLQLSGSCTALTWVLVAGSRPKKSRKSLQAQDAAGDQLHIALGTYKGSVVIYSLAEGKISRTLSGDSHDGPVTSITNDNAGHLYTVGADCRVVVWSLTDERSIAEWQVGPEKPQNIVYLQKSGTLAIGYRQLKVYDIKTKELVETFTGHSGEINTISSVASTDGTEFVLTTAKMERVICFWKIDKKGKNKASACTLLMEDLAYCLTSEVRDDGQLRVASVTRNGIIHIYLLNVNSLSAEKFVKPKVSLQIVSDGAETVEPLLAVAAHFVTDSNRSHEILFGYGSRQQLQFERFTPNYGEKLNVIVRADPKKLYAKKKGKEQPGYQAATKVQKPIVNQKNVEYNSALPISQKKVQNEVPMEARLEHLKIQGTKLSGGKLLTQSKTQLLMQALHSKDQAMIQAVLSTQDPETIQLTLDRLPLDYVNPLVNELSILLQGKHASVRSALRWLHALTSTHTSVLMSEDKEALREKLAVCLGVAEQRMHCLSEALQITGRVNLIINQMKRNADNHLNDNKALILDEDPDEPDPEAETNWSDLEEDQPGSPKSPLEDELVADDDLATDDGNADADTDSDVSMD", "length": 620 }, "evidence": [ { "id": "F1MCK7", "url": "https://omabrowser.org/oma/group/F1MCK7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "G3V920-1", "protein_name": "WD repeat-containing protein 43", "gene_name": "Wdr43", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAGGGGSCDPLAPAGVPCAFSPDSQAYFALASSDGHLRVWETANNRLHQEYVPSAHLSGTCTCLAWAPARLQAKESHQRKKRKSEAIGTNDQADLLALGTAVGSILLYSTVKGELHSKLISGGHEKRVNCIQWHQDNDCLYSCSDDKYIVEWSTQMCRVKCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLWVLETKEVYRHFTGHATPVSSLRFTTIRPNESQPFDGVTGLYFLSGAVHDRLLNVWQVRSENKEKSAVMSFTVTDEPVYIDLTLSENKEEPVKLAVVCRDGQVHLFEHVLNGHCKKPLTSNCTIQVATPGKGKKATPKPIPILAAGFCLDKMSLLLVYGSWFQPTIERLALNSKDTHICLERDISNCWAPTVETAITKVKTPVMNSEAKVLVPGVPGHHAPIKLLPAQPKEAENKRKLGGKEATIEERLGAMDLDRRGKKDDLLQTNSFPVLLAQGLESNDFEMLNKVLQTRNVNLIKKTVLRMPLHAVIPLLQELTKRLQGHPNSAVLMVQWLKCVLTIHASYLSTLPDLVHQLGTLYQLMESRVKTFQKLSHLHGKLILLVTQVTASEKTKKMPSPGLKAKLVYEEESSEEESDDEIPEKDSDDNWDEDEEKDSENDEAVDEDSENDEAVDEEDEDREAASEKELNGDSDLDPENESEEE", "length": 674 }, "evidence": [ { "id": "F1MCK7", "url": "https://omabrowser.org/oma/group/F1MCK7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LH57-1", "protein_name": "WD repeat-containing protein 43", "gene_name": "WDR43", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAGGGGVADPLSPAGVPCAFSPQNQAYFALASTDGHLRVWETANNRLHQEYVPSAHLSGTCTCLAWAPARSQAKEGPQRKKRKSEAVETSNQDDLLALGTAVGSVLLYSTVRGELHSKLINGGHDNKVNCIQWHQDNGCLYSCSDDKHIVEWNTQTCKVKCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLWVLETKEVYRHFTGHATPVSSLMFTTIRPPNESQPFDGITGLYFLSGAVHDRLLNVWQVRSENKEKNAVMSFTVTDEPVYIDLTLSENKEEPVKLAVVCRDGQVHLFEHILNGYCKKPLTSNCTIQIATPGKGKKSTPKPIPIIAAGFCSDKMSLLLVYGNWFQPIIERVALNSKEPHMCLVRDISNCWAPKVETAITKVRTPVMNSEAKVLVPGIPGHHAAIKPAPPQREDVENKRKSGKSEVSIEERLGALDIDPKKGKDSLPQTNSFPVLLTQGLESNDFEMLNKVLQTRNLNLIRRTVLRMPLHAVIPLLQELTKRLQGHPNSAVLMVQWLKCVLTVHASYLSTLPDLVPQLGTLYQLMESRVKTFQKLSHLHGKLILLVTQVTASEKTKGTACPPQKAKLVYEEESSEEESDDEIAEKDSDDNWDEDEEEKGSEKDEDVDEENEEEDEDAEEKDEENSEDRDVASEKELNGDSDLDPENESEEE", "length": 681 }, "evidence": [ { "id": "F1MCK7", "url": "https://omabrowser.org/oma/group/F1MCK7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q15061-1", "protein_name": "WD repeat-containing protein 43", "gene_name": "WDR43", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAGGGGSCDPLAPAGVPCAFSPHSQAYFALASTDGHLRVWETANNRLHQEYVPSAHLSGTCTCLAWAPARLQAKESPQRKKRKSEAVGMSNQTDLLALGTAVGSILLYSTVKGELHSKLISGGHDNRVNCIQWHQDSGCLYSCSDDKHIVEWNVQTCKVKCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLWVLETKEVYRHFTGHATPVSSLMFTTIRPPNESQPFDGITGLYFLSGAVHDRLLNVWQVRSENKEKSAVMSFTVTDEPVYIDLTLSENKEEPVKLAVVCRDGQVHLFEHILNGYCKKPLTSNCTIQIATPGKGKKSTPKPIPILAAGFCSDKMSLLLVYGSWFQPTIERVALNSREPHMCLVRDISNCWAPKVETAITKVRTPVMNSEAKVLVPGIPGHHAAIKPAPPQTEQVESKRKSGGNEVSIEERLGAMDIDTHKKGKEDLQTNSFPVLLTQGLESNDFEMLNKVLQTRNVNLIKKTVLRMPLHTIIPLLQELTKRLQGHPNSAVLMVQWLKCVLTVHASYLSTLPDLVPQLGTLYQLMESRVKTFQKLSHLHGKLILLITQVTASEKTKGATSPGQKAKLVYEEESSEEESDDEIADKDSEDNWDEDEEESESEKDEDVEEEDEDAEGKDEENGEDRDTASEKELNGDSDLDPENESEEE", "length": 677 }, "evidence": [ { "id": "F1MCK7", "url": "https://omabrowser.org/oma/group/F1MCK7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6ZQL4-1", "protein_name": "WD repeat-containing protein 43", "gene_name": "Wdr43", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAGGGGSYDPLAPAGVPCAFSPDSQAYFALASSDGQLRVWETANNRLHQEYVPSAHLSGTCTCLAWAPARLQAKESHQRKKRKSEVTGTKDQADLLALGTAVGSILLYSTVRGELHSKLTSGGHENRVNCIQWHQDNDCLYSCSDDKYIVEWSTQTCKVKCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLWVLETKEVYRHFTGHATPVSSLRFTTIRPNESQPSDGITGLYFLSGAVHDRLLNVWQVRSENKEKSAVMSFTVTDEPVYVDLTLSENKEEPVKLAVVCRDGQVHLFEHILNGHCKKPLTSNCTIQIATPGKGKKVTPKPIPILAASFCLDKMSLLLVYGNWFQPTIERVALNSKDTHICLERDISNCWAPTVETAITKVKTPVMNSEAKVLVPGIPGHHAPIKLPPAQPKEAENKRKLGSTEATIEERLGAMDLDRKGRKDDLQTNSFAVLLTQGLESNDFEILNKVLQTKNVNLIKRTVLRIPLRVVIPLLQELTKRLQGHPNSAALMIQWLKCVLTIHASYLSTLPDLVEQLGTLYQLMESRVKTFQKLSNLHGKLILLVTQVTASEKSKKMTSPGQKAKLVYEEESSEEESDDEVPEKDSDDNWDEDEDKDSEKDEGVDEDNEEEDEDMEDKEENEEDREVSSEKELNGDSDLDPENESEEE", "length": 677 }, "evidence": [ { "id": "F1MCK7", "url": "https://omabrowser.org/oma/group/F1MCK7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8T2Q3-1", "protein_name": "WD40 repeat-containing protein", "gene_name": "utp5", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTSVTTYDKDRELFARVGKDNKIEVFNSFNCKLLHTFVEIEESKNQIILLTFSTHDKSEKKEYYKNLVAVSNSGKIYMYDCIDFKKKGIFDTHSKNITAVVLGKRYLFTSSHGGKVSQWDIKTKHIIRSFESSEKSISSMGLNNRESQLAIANNDITFIDLSNFKESKKVSTGSNSIKQIQFTQDDKFLICNRYQPTIQIYNIEKLTANNTNTTEPTFTLNATSPTKSISIFTHEIKRASKTVTQYLISSLLQNSQINIWAYYQDDQYNTDAETPITEITNKSNQIISMNFHSASELILAFFEKEKYQFERVKFFDKKSFIKSITVENPIEFDKTTTINNKKQKTSETISIQGNAAEMKQDKVNLPTIKKSTDSIASAGTIVDLIAQSLKSDNDNLLLSSIKVNFNVIQSTVKSLPSPYAYSLLSKLLKYLATDNSKSLIVLPWINCIIKDHSSYLLSVPNLSKKLSVLNTIIQDKFELHNRLSKLVGKFELISSQTKGDKTESIDYEPSLVYDEASDNEQQDADGDMVEEDDEDDESDEFDGMEGADDEDDEEIDDDIADLMDDDDDL", "length": 569 }, "evidence": [ { "id": "F1MCK7", "url": "https://omabrowser.org/oma/group/F1MCK7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" }, { "name": "RNA polymerase II complex binding", "id": "GO:0000993", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000993", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" }, { "name": "transcription elongation factor activity", "id": "GO:0003711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003711", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" }, { "name": "rRNA processing", "id": "GO:0006364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006364", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" }, { "name": "positive regulation of rRNA processing", "id": "GO:2000234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000234", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" }, { "name": "regulation of transcription elongation by RNA polymerase II", "id": "GO:0034243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034243", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase I", "id": "GO:0045943", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045943", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" }, { "name": "regulation of stem cell population maintenance", "id": "GO:2000036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000036", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" }, { "name": "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000462", "evidence": [ { "database": "UniProtKB", "id": "F1MCK7", "url": "https://www.uniprot.org/uniprotkb/F1MCK7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 676, "end_pos": 678, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MCK7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 681, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MCK7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MCK7" } ], "lectin_list": [], "domain_list": [ { 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"tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MDI9-1", "uniprot_ac": "F1MDI9", "uniprot_id": "F1MDI9_BOVIN", "mass": { "chemical_mass": 123184.0, "monoisotopic_mass": 123184.0 }, "refseq": {}, "gene_names": [ { "name": "LOC132342100", "type": "recommended", "evidence": [ { "id": "F1MDI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDI9" } ] } ], "protein_names": [ { "name": "GB1/RHD3-type G domain-containing protein", "type": "recommended", "evidence": [ { "id": "F1MDI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDI9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MDI9", "url": "https://www.uniprot.org/uniprotkb/F1MDI9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC132342100", "url": "https://www.uniprot.org/uniprotkb/F1MDI9", "locus": {} } ], "crossref": [ { "id": "F1MDI9", "url": "https://alphafold.ebi.ac.uk/entry/F1MDI9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037634", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037634", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000038938", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038938", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01851", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01851", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16269", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16269", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "132342100", "url": "https://www.ncbi.nlm.nih.gov/gene/132342100", "database": "GeneID", "categories": [ "Genome 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"database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BEE4", "url": "https://www.orthodb.org/?gene=E1BEE4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MDI9", "url": "https://www.orthodb.org/?gene=F1MDI9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10751", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10751", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02263", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02263", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02841", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02841", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9948001", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9948001", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9953170", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9953170", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAF6DME3", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DME3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEE4", "url": "https://www.uniprot.org/uniprotkb/E1BEE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BEE4-1", "url": "https://www.uniprot.org/uniprotkb/E1BEE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDI9", "url": "https://www.uniprot.org/uniprotkb/F1MDI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDI9-1", "url": "https://www.uniprot.org/uniprotkb/F1MDI9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDQLHYVTELTRRIRAKSSPDKHEVLDSANFVSFFPDFVWTLRDFSLELVADGQPITADEYLEYSLKLKQGNDKKTKNFNEPRLCIRKFFPEKKCFIFDRPAHRKYLIHLEQLQEEDLNPKFREQVADFCFYILSHSKAKTLSGGITVNGPRLESLVLTYVNSISSGDLPCMESAVLALAEIENLAAVQKAIAHYDQQMDQKLKLPTETLQELLDLHRATEKEAIEVFMKNSFKDVDQVFQKKLGDKLEAKLDDFCKQNMKASSDYCMALIQDICHPLYEDVKQGTFFKPGAYYLFIKKMNEPKNKYHQVPRKGVQTGETLRKYLDSKEDVADALLQIDQLLTEKEKEIEVERMKYEAANKILEEMQKKNEQMMREKEASYQEHVKQLTEKMEKERAQLIAEQERVLALQVLMASGSIKMDPIYLVENRKSQLSVNPKALKILHQISQPLVVVAITGLYQTGKSYLMNRLAGQNHGFRLGSTVRSETKGIWMWCVPHPSKENHTLVLLDTEGLGNVEKEDSKNDLWIFALAVLLSSTLIYNSMNSINDQALQQLHYVTELTELIRSKSSPSSDKVEDSARFVSFFPDFIWTVRDFMLELKLDGSSITEDEYLENALKLIPGKNTGVGCHFPLQEIFLTQGLNSGLLHCKQMFYRLSHEESSLADKGPQIQNLNLPRECIRKFFPKRKCFVFDRPASNKKQLLHLEEMPDNQLDEDFQKQSKDFCSYIYTHAKTKTLKEGITVTGKRLGPLVEAYVNAINSGSVPCLENAVTTLAQLENSAAVQKAADHYSEQMAQRLSLPIDALQELLEVHTACEKEAIAVFMEHSFKDENQDFQKKLAIMIDKKKDDFLLQNEEASVRYCQTEFKKLSEPLMTSISEGTFLVPGGHHCYLEARNKFEENYKLIPRKGVKANQVLQSFLQSQAEVEAAILKVDQALTDADKAMAEERTKRQAAEMKQDLLTQELNDEKQKMEAQERSHKENIAQVKEKLEMERENLLREQEAVLAHKLKIQEEMLTEGFERKANELHEEILQLQKEIERTKDDRLLENVRLLTQIGLILMASRSRFLNCV", "length": 1070, "header": "tr|F1MDI9-1|F1MDI9_BOVIN Isoform 1 of GB1/RHD3-type G domain-containing protein OS=Bos taurus OX=9913 GN=LOC132342100 PE=3 SV=5 CANONICAL=F1MDI9-1" }, "isoforms": [ { "isoform_ac": "A0AAF6DME3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DME3/entry", "sequence": { "sequence": 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"length": 1029, "header": "tr|A0AAF6DME3-1|F1MDI9_BOVIN Computationally mapped isoform of GB1/RHD3-type G domain-containing protein OS=Bos taurus OX=9913 GN=LOC132342100 PE=3 SV=2 CANONICAL=F1MDI9-1" }, "locus": { "chromosome": "3", "start_pos": 54276636, "end_pos": 54195567, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031134.7", "url": "https://www.ensembl.org/id/ENSBTAT00000031134.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031094.6", "url": "https://www.ensembl.org/id/ENSBTAP00000031094.6" } ] } }, { "isoform_ac": "E1BEE4-1", "url": "https://www.uniprot.org/uniprotkb/E1BEE4/entry", "sequence": { "sequence": "MDQLHYVTELTRRIRAKSSPDKHEVLDSANFVSFFPDFVWTLRDFSLELVADGQPITADEYLEYSLKLKQGNDKKTKNFNEPRLCIRKFFPEKKCFIFDRPAHRKYLIHLEQLQEEDLNPKFREQVADFCFYILSHSKAKTLSGGITVNGPRLESLVLTYVNSISSGDLPCMESAVLALAEIENLAAVQKAIAHYDQQMDQKLKLPTETLQELLDLHRATEKEAIEVFMKNSFKDVDQVFQKKLGDKLEAKLDDFCKQNMKASSDYCMALIQDICHPLYEDVKQGTFFKPGAYYLFIKKMNEPKNKYHQVPRKGVQTGETLRKYLDSKEDVADALLQIDQLLTEKEKEIEVERMKYEAANKILEEMQKKNEQMMREKEASYQEHVKQLTEKMEKERAQLIAEQERVLALQVLMASGSIKMDPIYLVENRKSQLSVNPKALKILHQISQPLVVVAITGLYQTGKSYLMNRLAGQNHGFRLGSTVRSETKGIWMWCVPHPSKENHTLVLLDTEGLGNVEKEDSKNDLWIFALAVLLSSTLIYNSMNSINDQALQQLHYVTELTELIRSKSSPSSDKVEDSARFVSFFPDFIWTVRDFMLELKLDGSSITEDEYLENALKLIPDKGPQIQNLNLPRECIRKFFPKRKCFVFDRPASNKKQLLHLEEMPDNQLDEDFQKQSKDFCSYIYTHAKTKTLKEGITVTGKRLGPLVEAYVNAINSGSVPCLENAVTTLAQLENSAAVQKAADHYSEQMAQRLSLPIDALQELLEVHTACEKEAIAVFMEHSFKDENQDFQKKLAIMIDKKKDDFLLQNEEASVRYCQTEFKKLSEPLMTSISEGTFLVPGGHHCYLEARNKFEENYKLIPRKGVKANQVLQSFLQSQAEVEAAILKVDQALTDADKAMAEERTKRQAAEMKQDLLTQELNDEKQKMEAQERSHKENIAQVKEKLEMERENLLREQEAVLAHKLKIQEEMLTEGFERKANELHEEILQLQKEIERTKDDRLLENVRLLTQIGLILMASRSRFLNCV", "length": 1027, "header": "tr|E1BEE4-1|E1BEE4_BOVIN Computationally mapped isoform of GB1/RHD3-type G domain-containing protein OS=Bos taurus OX=9913 GN=LOC132342100 PE=3 SV=5 CANONICAL=F1MDI9-1" }, "locus": { "chromosome": "3", "start_pos": 54268435, "end_pos": 54195567, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054358.5", "url": "https://www.ensembl.org/id/ENSBTAT00000054358.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048354.5", "url": "https://www.ensembl.org/id/ENSBTAP00000048354.5" } ] } }, { "isoform_ac": "F1MDI9-1", "url": "https://www.uniprot.org/uniprotkb/F1MDI9/entry", "sequence": { "sequence": "MDQLHYVTELTRRIRAKSSPDKHEVLDSANFVSFFPDFVWTLRDFSLELVADGQPITADEYLEYSLKLKQGNDKKTKNFNEPRLCIRKFFPEKKCFIFDRPAHRKYLIHLEQLQEEDLNPKFREQVADFCFYILSHSKAKTLSGGITVNGPRLESLVLTYVNSISSGDLPCMESAVLALAEIENLAAVQKAIAHYDQQMDQKLKLPTETLQELLDLHRATEKEAIEVFMKNSFKDVDQVFQKKLGDKLEAKLDDFCKQNMKASSDYCMALIQDICHPLYEDVKQGTFFKPGAYYLFIKKMNEPKNKYHQVPRKGVQTGETLRKYLDSKEDVADALLQIDQLLTEKEKEIEVERMKYEAANKILEEMQKKNEQMMREKEASYQEHVKQLTEKMEKERAQLIAEQERVLALQVLMASGSIKMDPIYLVENRKSQLSVNPKALKILHQISQPLVVVAITGLYQTGKSYLMNRLAGQNHGFRLGSTVRSETKGIWMWCVPHPSKENHTLVLLDTEGLGNVEKEDSKNDLWIFALAVLLSSTLIYNSMNSINDQALQQLHYVTELTELIRSKSSPSSDKVEDSARFVSFFPDFIWTVRDFMLELKLDGSSITEDEYLENALKLIPGKNTGVGCHFPLQEIFLTQGLNSGLLHCKQMFYRLSHEESSLADKGPQIQNLNLPRECIRKFFPKRKCFVFDRPASNKKQLLHLEEMPDNQLDEDFQKQSKDFCSYIYTHAKTKTLKEGITVTGKRLGPLVEAYVNAINSGSVPCLENAVTTLAQLENSAAVQKAADHYSEQMAQRLSLPIDALQELLEVHTACEKEAIAVFMEHSFKDENQDFQKKLAIMIDKKKDDFLLQNEEASVRYCQTEFKKLSEPLMTSISEGTFLVPGGHHCYLEARNKFEENYKLIPRKGVKANQVLQSFLQSQAEVEAAILKVDQALTDADKAMAEERTKRQAAEMKQDLLTQELNDEKQKMEAQERSHKENIAQVKEKLEMERENLLREQEAVLAHKLKIQEEMLTEGFERKANELHEEILQLQKEIERTKDDRLLENVRLLTQIGLILMASRSRFLNCV", "length": 1070, "header": "tr|F1MDI9-1|F1MDI9_BOVIN Isoform 1 of GB1/RHD3-type G domain-containing protein OS=Bos taurus OX=9913 GN=LOC132342100 PE=3 SV=5 CANONICAL=F1MDI9-1" }, "locus": { "chromosome": "3", "start_pos": 54268435, "end_pos": 54195567, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056911.5", "url": "https://www.ensembl.org/id/ENSBTAT00000056911.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050757.5", "url": "https://www.ensembl.org/id/ENSBTAP00000050757.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:132342100", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:132342100", "resource": "KEGG Pathway" }, { "id": "R-BTA-9948001", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9948001", "resource": "Reactome", "description": "CASP4 inflammasome assembly" }, { "id": "R-BTA-9953170", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9953170", "resource": "Reactome", "description": "GBP-mediated host defense" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "F1MDI9", "url": "https://www.uniprot.org/uniprotkb/F1MDI9" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1MDI9", "url": "https://www.uniprot.org/uniprotkb/F1MDI9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "F1MDI9", "url": "https://www.uniprot.org/uniprotkb/F1MDI9" } ], "pmid": "" }, { "name": "defense response to Gram-positive bacterium", "id": "GO:0050830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830", "evidence": [ { "database": "UniProtKB", "id": "F1MDI9", "url": "https://www.uniprot.org/uniprotkb/F1MDI9" } ], "pmid": "" }, { "name": "cellular response to type II interferon", "id": "GO:0071346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071346", "evidence": [ { "database": "UniProtKB", "id": "F1MDI9", "url": "https://www.uniprot.org/uniprotkb/F1MDI9" } ], "pmid": "" }, { "name": "defense response to protozoan", "id": "GO:0042832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042832", "evidence": [ { "database": "UniProtKB", "id": "F1MDI9", "url": "https://www.uniprot.org/uniprotkb/F1MDI9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "F1MDI9", "url": "https://www.uniprot.org/uniprotkb/F1MDI9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 502, "end_pos": 504, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MDI9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1070, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MDI9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MDI9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MDI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDI9" }, { "id": "PS51715", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51715" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GB1/RHD3-type G", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 138, "start_aa": "Met", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 502, "end_pos": 504 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPG0-1", "uniprot_ac": "E1BPG0", "uniprot_id": "E1BPG0_BOVIN", "mass": { "chemical_mass": 53145.0, "monoisotopic_mass": 53145.0 }, "refseq": {}, "gene_names": [ { "name": "MCAT", "type": "recommended", "evidence": [ { "id": "E1BPG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG0" } ] } ], "protein_names": [ { "name": "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial", "type": "recommended", "evidence": [ { "id": "E1BPG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG0/entry#names_and_taxonomy" } ] }, { "name": "2.3.1.39", "type": "synonym", "evidence": [ { "id": "E1BPG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG0/entry#names_and_taxonomy" } ] }, { "name": "Mitochondrial malonyltransferase", "type": "synonym", "evidence": [ { "id": "E1BPG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG0/entry#names_and_taxonomy" } ] }, { "name": "[Acyl-carrier-protein] malonyltransferase", "type": "synonym", "evidence": [ { "id": "E1BPG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPG0", "url": "https://www.uniprot.org/uniprotkb/E1BPG0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MCAT", "url": "https://www.uniprot.org/uniprotkb/E1BPG0", "locus": { "chromosome": "5", "start_pos": 113908267, "end_pos": 113925343, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002413", "url": "https://www.ensembl.org/id/ENSBTAG00000002413" } ] } } ], "crossref": [ { "id": "E1BPG0", "url": "https://alphafold.ebi.ac.uk/entry/E1BPG0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002413", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002413", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001227", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001227", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014043", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014043", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BPG0", "url": "https://www.orthodb.org/?gene=E1BPG0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47170", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47170", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47170:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47170:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00698", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00698", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-77289", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77289", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "41792", "url": "https://www.rhea-db.org/rhea/41792", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BPG0", "url": "https://www.uniprot.org/uniprotkb/E1BPG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPG0-1", "url": "https://www.uniprot.org/uniprotkb/E1BPG0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSRAQTQKLWCTDFVAPWHGESSWTRDRTRVPCNGRRIPNHWTTRETSRRQSKETQQRRCLSPPGGKYIKDRAAPPEVGPRSPRRRARGPGSLTMSVRVARAARAWARSVSGRRGSSNCPRPPPAAVDVAALLRDATAADGGSQDAQAAAGRREPGQCSVLLFPGQGSQVVGMGRGLLRYPRVRELYDAARRVLGYDLLELSLRGPQEALDRTVHCQPAVFVASLAAVEKLHHLQPAVIENCVAAAGFSVGEFAALVFAGAMEFSEGLYAVKIRAEAMQEASEAVPSGMLSVLGQRQSKFTVACLEAQEHCKTRGIENPVCVVSNYLFPDCRVISGHLEALQFLQKNSSKYHFRRTKMLPVSGGFHTRLMEPAVEPLVQVLKAIDVKKPLVSVHSNVDGNRYMHPKHIQKLLAQQVVSPVKWEQTMHAIYERRKGTAFPQTFEVGPGKQLGAILRSCNLQAWRSYSHVEVLEAGEDPEEPL", "length": 482, "header": "tr|E1BPG0-1|E1BPG0_BOVIN Isoform 1 of Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Bos taurus OX=9913 GN=MCAT PE=3 SV=2 CANONICAL=E1BPG0-1" }, "isoforms": [ { "isoform_ac": "E1BPG0-1", "url": "https://www.uniprot.org/uniprotkb/E1BPG0/entry", "sequence": { "sequence": "MGSRAQTQKLWCTDFVAPWHGESSWTRDRTRVPCNGRRIPNHWTTRETSRRQSKETQQRRCLSPPGGKYIKDRAAPPEVGPRSPRRRARGPGSLTMSVRVARAARAWARSVSGRRGSSNCPRPPPAAVDVAALLRDATAADGGSQDAQAAAGRREPGQCSVLLFPGQGSQVVGMGRGLLRYPRVRELYDAARRVLGYDLLELSLRGPQEALDRTVHCQPAVFVASLAAVEKLHHLQPAVIENCVAAAGFSVGEFAALVFAGAMEFSEGLYAVKIRAEAMQEASEAVPSGMLSVLGQRQSKFTVACLEAQEHCKTRGIENPVCVVSNYLFPDCRVISGHLEALQFLQKNSSKYHFRRTKMLPVSGGFHTRLMEPAVEPLVQVLKAIDVKKPLVSVHSNVDGNRYMHPKHIQKLLAQQVVSPVKWEQTMHAIYERRKGTAFPQTFEVGPGKQLGAILRSCNLQAWRSYSHVEVLEAGEDPEEPL", "length": 482, "header": "tr|E1BPG0-1|E1BPG0_BOVIN Isoform 1 of Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Bos taurus OX=9913 GN=MCAT PE=3 SV=2 CANONICAL=E1BPG0-1" }, "locus": { "chromosome": "5", "start_pos": 113925144, "end_pos": 113909105, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003130.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003130.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003130.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003130.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-77289", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77289", "resource": "Reactome", "description": "Mitochondrial Fatty Acid Beta-Oxidation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "E1BPG0", "url": "https://www.uniprot.org/uniprotkb/E1BPG0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "fatty acid biosynthetic process", "id": "GO:0006633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006633", "evidence": [ { "database": "UniProtKB", "id": "E1BPG0", "url": "https://www.uniprot.org/uniprotkb/E1BPG0" } ], "pmid": "" }, { "name": "mitochondrial small ribosomal subunit assembly", "id": "GO:0180026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0180026", "evidence": [ { "database": "UniProtKB", "id": "E1BPG0", "url": "https://www.uniprot.org/uniprotkb/E1BPG0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "[acyl-carrier-protein] S-malonyltransferase activity", "id": "GO:0004314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004314", "evidence": [ { "database": "UniProtKB", "id": "E1BPG0", "url": "https://www.uniprot.org/uniprotkb/E1BPG0" } ], "pmid": "" }, { "name": "RNA folding chaperone", "id": "GO:0140691", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140691", "evidence": [ { "database": "UniProtKB", "id": "E1BPG0", "url": "https://www.uniprot.org/uniprotkb/E1BPG0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "41792", "name": "", "equation": "holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BPG0-1", "A0ABI0NT64-1", "Q71SP7-1" ], "evidence": [ { "id": "41792", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41792" } ] }, { "id": "R-BTA-8933547", "name": "MCAT transfers Mal from Mal-CoA to NDUFAB1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [ "R-ALL-977314", "R-BTA-163925" ], "output_participant_list": [ "R-BTA-8934586" ], "enzyme_list": [ "E1BPG0-1" ], "evidence": [ { "id": "R-BTA-8933547", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8933547" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-977314", "participant_name": "Malonyl-CoA [mitochondrial matrix]", "crossref": [ { "id": "57384", "database": "ChEBI", "url": "" }, { "id": "ZINC000008551112", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-BTA-163925", "participant_name": "phospho-NDUFAB1 [mitochondrial inner membrane]", "crossref": [ { "id": "G3X6L0", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000006391", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000008382", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000008382", "database": "ENSEMBL", "url": "" }, { "id": "31952", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-8934586", "participant_name": "phospho-NDUFAB1 [mitochondrial inner membrane]", "crossref": [ { "id": "ENSBTAP00000008382", "database": "ENSEMBL", "url": "" }, { "id": "G3X6L0", "database": "UniProt", "url": "" }, { "id": "31952", "database": "VGNC", "url": "" }, { "id": "ENSBTAT00000008382", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000006391", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0ABI0NT64", "gene_name": "FASN", "activity": [ { "ec_number": "1.1.1.100", "activity": "a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+).", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "1.3.1.39", "activity": "a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+).", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "2.3.1.38", "activity": "holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA.", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "2.3.1.39", "activity": "holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA.", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "2.3.1.41", "activity": "a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2.", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "2.3.1.85", "activity": "acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "3.1.2.14", "activity": "hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H(+).", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "4.2.1.59", "activity": "a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O.", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "3.1.2.14", "activity": "", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "2.3.1.38", "activity": "", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "2.3.1.41", "activity": "", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "1.1.1.100", "activity": "", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "2.3.1.85", "activity": "", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "1.3.1.39", "activity": "", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "4.2.1.59", "activity": "", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] }, { "ec_number": "2.3.1.39", "activity": "", "evidence": [ { "id": "A0ABI0NT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT64" } ] } ] }, { "uniprot_ac": "E1BPG0", "gene_name": "MCAT", "activity": [ { "ec_number": "2.3.1.39", "activity": "holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA.", "evidence": [ { "id": 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"MAHENFTRVIEFILTGVSERPDLQIPLFFVFLVIYGLTVTGNLSIITLTSVDSRLQTPMYFFLRHLAIINLGNSTVIAPKMLINFLVKKHTTSFYECATQLGMFLVFIVAEIFILAVMAYDRYVAICNPLLYLAVVSRRVCFLLVSLTYLYSFSTAIVASSSVFSMSYCSSNVINHFYCDIVPLIALSCSDTSFPETVVFVSASTNLVFSIITVVASYFNIVLSILRIRSSEGRKRAFSTCTSHMTAVSVFYGTLLFMYLQPQTNHSMGADKMASVFYTLVIPMLNPMIYSLRNKDVKAALKRFLTNS", "length": 308, "header": "tr|E1BPG6-1|E1BPG6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8J2E PE=3 SV=4 CANONICAL=E1BPG6-1" }, "isoforms": [ { "isoform_ac": "E1BPG6-1", "url": "https://www.uniprot.org/uniprotkb/E1BPG6/entry", "sequence": { "sequence": "MAHENFTRVIEFILTGVSERPDLQIPLFFVFLVIYGLTVTGNLSIITLTSVDSRLQTPMYFFLRHLAIINLGNSTVIAPKMLINFLVKKHTTSFYECATQLGMFLVFIVAEIFILAVMAYDRYVAICNPLLYLAVVSRRVCFLLVSLTYLYSFSTAIVASSSVFSMSYCSSNVINHFYCDIVPLIALSCSDTSFPETVVFVSASTNLVFSIITVVASYFNIVLSILRIRSSEGRKRAFSTCTSHMTAVSVFYGTLLFMYLQPQTNHSMGADKMASVFYTLVIPMLNPMIYSLRNKDVKAALKRFLTNS", "length": 308, "header": "tr|E1BPG6-1|E1BPG6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus 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"start_pos": 42, "end_pos": 44 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 73, "end_pos": 75 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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"categories": [ "Enzyme and Pathway" ] }, { "id": "RETRMQH", "url": "https://omabrowser.org/oma/group/RETRMQH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPK1", "url": "https://www.orthodb.org/?gene=E1BPK1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45632", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45632:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24681", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179395", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BPK1", "url": "https://www.uniprot.org/uniprotkb/E1BPK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPK1-1", "url": "https://www.uniprot.org/uniprotkb/E1BPK1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAPKDPPQQPPQQQPPPPPAQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGSWTELEGDVAEPLAGPACATVILPACVPYNK", "length": 626, "header": "tr|E1BPK1-1|E1BPK1_BOVIN Isoform 1 of Kelch-like protein 14 OS=Bos taurus OX=9913 GN=KLHL14 PE=4 SV=2 CANONICAL=E1BPK1-1" }, "isoforms": [ { "isoform_ac": "E1BPK1-1", "url": "https://www.uniprot.org/uniprotkb/E1BPK1/entry", "sequence": { "sequence": "MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAPKDPPQQPPQQQPPPPPAQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGSWTELEGDVAEPLAGPACATVILPACVPYNK", "length": 626, "header": "tr|E1BPK1-1|E1BPK1_BOVIN Isoform 1 of Kelch-like protein 14 OS=Bos taurus OX=9913 GN=KLHL14 PE=4 SV=2 CANONICAL=E1BPK1-1" }, "locus": { "chromosome": "24", "start_pos": 24498072, "end_pos": 24385001, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000026649.6", "url": "https://www.ensembl.org/id/ENSBTAT00000026649.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000026649.5", "url": "https://www.ensembl.org/id/ENSBTAP00000026649.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517316", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517316", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PQZ9-1", "protein_name": "Kelch-like protein 14", "gene_name": "KLHL14", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSGGGHPHALALGPGAQDGLGGAPPKEPPPPPQEEPGTPSSSPEDKLLASPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLVLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKNLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYSPEKGTWTELEGDVAEPLAGPACSTVILPACVPYNK", "length": 622 }, "evidence": [ { "id": "E1BPK1", "url": "https://omabrowser.org/oma/group/E1BPK1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8M1PS01-1", "protein_name": "Kelch-like protein 14", "gene_name": "klhl14", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGGVRSPEVMSRSGDRTSTFDPTHSDTLLHGLNLLWRKQLFCDVTLTAQGQQFHCHRAVLASCSQYFRSLFSTHSMLSREDGLAAKDQGSSGTPSSSPDDKLLPSPHSTINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILNIPQITKLSVQFLNDQISVQNYKQICKIAALHGLDETKKLANKYLVEDVLLLNFEEMCAMLDALPPPVESELALFQMSVLWLEHDRETRMHYAPDLMKRLRFALIPAPELVERVQSVDFMRSDPVCQKLLLDAMNYHLMPFRQHCRQTTASRIRSNKRMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLLLLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFFACCLDKHLYVVGGRNETGYLSSVEAYNLETNEWNYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVSWLYCYDPVMDVWARKQDMNTKRAIHALAGMNDRLYAIGGNHLKGFSHLDVMLVECYDPKADQWSILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYSPEKATWTEMEGEVAEPLAGPACATVILPACLPFNK", "length": 616 }, "evidence": [ { "id": "E1BPK1", "url": "https://omabrowser.org/oma/group/E1BPK1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZYQ7-1", "protein_name": "Kelch-like protein 14", "gene_name": "Klhl14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAPKDQQQQQQPQQQPSQQQQQPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLDTNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELEGDVAEPLAGPACATVILPACVPYNK", "length": 630 }, "evidence": [ { "id": "E1BPK1", "url": "https://omabrowser.org/oma/group/E1BPK1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SAK5-1", "protein_name": "Kelch-like protein 14", "gene_name": "KLHL14", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAPKDPQQQQQPPQQPPQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELEGDVAEPLAGPACATVILPACVPYNK", "length": 630 }, "evidence": [ { "id": "E1BPK1", "url": "https://omabrowser.org/oma/group/E1BPK1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q69ZK5-1", "protein_name": "Kelch-like protein 14", "gene_name": "Klhl14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAPKDQQQQQQPQQQPPQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLDTNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELEGDVAEPLAGPACATVILPACVPYNK", "length": 630 }, "evidence": [ { "id": "E1BPK1", "url": "https://omabrowser.org/oma/group/E1BPK1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P2G3-1", "protein_name": "Kelch-like protein 14", "gene_name": "KLHL14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELEGDVAEPLAGPACVTVILPSCVPYNK", "length": 628 }, "evidence": [ { "id": "E1BPK1", "url": "https://omabrowser.org/oma/group/E1BPK1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "E1BPK1", "url": "https://www.uniprot.org/uniprotkb/E1BPK1" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "E1BPK1", "url": "https://www.uniprot.org/uniprotkb/E1BPK1" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "E1BPK1", "url": "https://www.uniprot.org/uniprotkb/E1BPK1" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "E1BPK1", "url": "https://www.uniprot.org/uniprotkb/E1BPK1" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "E1BPK1", "url": "https://www.uniprot.org/uniprotkb/E1BPK1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" }, { "start_pos": 431, "end_pos": 433, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPK1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 626, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPK1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPK1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPK1" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 33, "end_pos": 149, "start_aa": "Cys", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 144, "end_pos": 146 }, { "start_pos": 431, "end_pos": 433 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPK8-1", "uniprot_ac": "E1BPK8", "uniprot_id": "E1BPK8_BOVIN", "mass": { "chemical_mass": 76450.0, "monoisotopic_mass": 76450.0 }, "refseq": {}, "gene_names": [ { "name": "LRRC4B", "type": "recommended", "evidence": [ { "id": "E1BPK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPK8" } ] } ], "protein_names": [ { "name": "Leucine rich repeat containing 4B", "type": "synonym", "evidence": [ { "id": "E1BPK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPK8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPK8", "url": "https://www.uniprot.org/uniprotkb/E1BPK8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LRRC4B", "url": "https://www.uniprot.org/uniprotkb/E1BPK8", "locus": { "chromosome": "18", "start_pos": 56644863, "end_pos": 56687127, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006841", "url": "https://www.ensembl.org/id/ENSBTAG00000006841" } ] } } ], "crossref": [ { "id": "E1BPK8", "url": "https://alphafold.ebi.ac.uk/entry/E1BPK8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006841", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006841", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": 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"E1BPM9-1", "url": "https://www.uniprot.org/uniprotkb/E1BPM9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEIVYVYVKKRSEFGKQCNFSDRQAELNIDIPPNPELAEQFVERNPVDTGIQCSTSMSEHEANTERFEMETRGVNHIEGGWPKDVNPLELEQTIRFRKKVEKDENYINAIMQLGSIMEHCIKQNNAIDIYQEYFDDEDAVEVTDEAPSAKTINVFRDPQEIKRPATHVSWHPDGNRKLAVAYSCLNFQRAPEGMSNESYIWDLENPNRPEITLKPSSPLVTLEYNPKDSHVLLAGCYNGQIACWDTRKGSLVAELSTIEFSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKLSEPTEVVIMDITKKEHLENALGAISLEFESTLPTKFMVGTEQGVVISCNRKGKTPAEKIVCTFSGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSIMWTKYHMAYLTDAAWSPVRPAVFFTTKMDGTLDIWDFVFKQCDPALSLKVCDEALFCLRVQDNGCFIACGSQLGTTTLLEVSNGLCTLQRNEKNTASSMFERETRREKILEARHREMRLKEKGKAEGRDDELRDEPPILNLEELVTKAEEEFFDIIFTELKRKEAEAMKKQPKPKQPSQETDEEVQGEEEAEEERGDGEGEEGGGVQ", "length": 607, "header": "tr|E1BPM9-1|E1BPM9_BOVIN Isoform 1 of Dynein axonemal intermediate chain 2 OS=Bos taurus OX=9913 GN=DNAI2 PE=1 SV=2 CANONICAL=E1BPM9-1" }, "isoforms": [ { "isoform_ac": "E1BPM9-1", "url": "https://www.uniprot.org/uniprotkb/E1BPM9/entry", "sequence": { "sequence": "MEIVYVYVKKRSEFGKQCNFSDRQAELNIDIPPNPELAEQFVERNPVDTGIQCSTSMSEHEANTERFEMETRGVNHIEGGWPKDVNPLELEQTIRFRKKVEKDENYINAIMQLGSIMEHCIKQNNAIDIYQEYFDDEDAVEVTDEAPSAKTINVFRDPQEIKRPATHVSWHPDGNRKLAVAYSCLNFQRAPEGMSNESYIWDLENPNRPEITLKPSSPLVTLEYNPKDSHVLLAGCYNGQIACWDTRKGSLVAELSTIEFSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKLSEPTEVVIMDITKKEHLENALGAISLEFESTLPTKFMVGTEQGVVISCNRKGKTPAEKIVCTFSGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSIMWTKYHMAYLTDAAWSPVRPAVFFTTKMDGTLDIWDFVFKQCDPALSLKVCDEALFCLRVQDNGCFIACGSQLGTTTLLEVSNGLCTLQRNEKNTASSMFERETRREKILEARHREMRLKEKGKAEGRDDELRDEPPILNLEELVTKAEEEFFDIIFTELKRKEAEAMKKQPKPKQPSQETDEEVQGEEEAEEERGDGEGEEGGGVQ", "length": 607, "header": "tr|E1BPM9-1|E1BPM9_BOVIN Isoform 1 of Dynein axonemal intermediate chain 2 OS=Bos taurus OX=9913 GN=DNAI2 PE=1 SV=2 CANONICAL=E1BPM9-1" }, "locus": { "chromosome": "19", "start_pos": 57141901, "end_pos": 57116676, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022242.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022242.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022242.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022242.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structural diversity of axonemes across mammalian motile cilia.", "journal": "Nature", "date": "2025", "authors": "Leung Miguel Ricardo, Sun Chen, Zeng Jianwei, Anderson Jacob R, Niu Qingwei, Huang Wei, Noteborn Willem E M, Brown Alan, Zeev-Ben-Mordehai Tzviya, Zhang Rui", "evidence": [ { "database": "UniProtKB", "id": "E1BPM9", "url": "https://www.uniprot.org/uniprotkb/E1BPM9" } ], "reference": [ { "type": "PubMed", "id": "39743588", "url": "https://glygen.org/publication/PubMed/39743588" } ] } ], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "E1BPM9", "url": "https://www.uniprot.org/uniprotkb/E1BPM9" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "E1BPM9", "url": "https://www.uniprot.org/uniprotkb/E1BPM9" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "E1BPM9", "url": "https://www.uniprot.org/uniprotkb/E1BPM9" } ], "pmid": "" }, { "name": "outer dynein arm", "id": "GO:0036157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036157", "evidence": [ { "database": "UniProtKB", "id": "E1BPM9", "url": "https://www.uniprot.org/uniprotkb/E1BPM9" } ], "pmid": "" }, { "name": "dynein axonemal particle", "id": "GO:0120293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120293", "evidence": [ { "database": "UniProtKB", "id": "E1BPM9", "url": "https://www.uniprot.org/uniprotkb/E1BPM9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "microtubule motor activity", "id": "GO:0003777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003777", "evidence": [ { "database": "UniProtKB", "id": "E1BPM9", "url": "https://www.uniprot.org/uniprotkb/E1BPM9" } ], "pmid": "" }, { "name": "dynein light chain binding", "id": "GO:0045503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045503", "evidence": [ { "database": "UniProtKB", "id": "E1BPM9", "url": "https://www.uniprot.org/uniprotkb/E1BPM9" } ], "pmid": "" }, { "name": "dynein heavy chain binding", "id": "GO:0045504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045504", "evidence": [ { "database": "UniProtKB", "id": "E1BPM9", "url": "https://www.uniprot.org/uniprotkb/E1BPM9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cilium movement", "id": "GO:0003341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003341", "evidence": [ { "database": "UniProtKB", "id": "E1BPM9", "url": "https://www.uniprot.org/uniprotkb/E1BPM9" } ], "pmid": "" }, { "name": "outer dynein arm assembly", "id": "GO:0036158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036158", "evidence": [ { "database": "UniProtKB", "id": "E1BPM9", "url": "https://www.uniprot.org/uniprotkb/E1BPM9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPM9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 607, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPM9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPM9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 }, { "start_pos": 19, "end_pos": 21 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPN4-1", "uniprot_ac": "E1BPN4", "uniprot_id": "E1BPN4_BOVIN", "mass": { "chemical_mass": 55023.0, "monoisotopic_mass": 55023.0 }, "refseq": { "ac": "NP_001192524", "name": "carbohydrate sulfotransferase 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192524" }, "gene_names": [ { "name": "CHST3", "type": "recommended", "evidence": [ { "id": "E1BPN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPN4" } ] }, { "name": "CHST3", "type": "synonym", "evidence": [ { "id": "NP_001192524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192524" } ] } ], "protein_names": [ { "name": "Carbohydrate sulfotransferase 3", "type": "synonym", "evidence": [ { "id": "E1BPN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPN4/entry#names_and_taxonomy" } ] }, { "name": "carbohydrate sulfotransferase 3", "type": "synonym", "evidence": [ { "id": "NP_001192524", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192524" } ] } ], "function": [ { "annotation": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan. Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen.", "evidence": [ { "database": "UniProtKB", "id": "E1BPN4", "url": "https://www.uniprot.org/uniprotkb/E1BPN4#function" }, { "database": "UniProtKB", "id": "ARBA00059789", "url": "https://www.uniprot.org/uniprotkb/ARBA00059789#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPN4", "url": "https://www.uniprot.org/uniprotkb/E1BPN4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHST3", "url": "https://www.uniprot.org/uniprotkb/E1BPN4", "locus": { "chromosome": "28", "start_pos": 28098453, "end_pos": 28084455, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011014", "url": "https://www.ensembl.org/id/ENSBTAG00000011014" } ] } } ], "crossref": [ { "id": "E1BPN4", "url": "https://alphafold.ebi.ac.uk/entry/E1BPN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011014", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011014", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "506758", "url": "https://www.ncbi.nlm.nih.gov/gene/506758", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016469", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016469", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506758", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506758", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KWRFGMP", "url": "https://omabrowser.org/oma/group/KWRFGMP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPN4", "url": "https://www.orthodb.org/?gene=E1BPN4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10704", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10704", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10704:SF60", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10704:SF60", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00685", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00685", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2022854", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022854", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2022870", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022870", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192524", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11108", "url": "https://www.rhea-db.org/rhea/11108", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BPN4", "url": "https://www.uniprot.org/uniprotkb/E1BPN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPN4-1", "url": "https://www.uniprot.org/uniprotkb/E1BPN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKGLSLPQDCRHFLHSLRMRSKYALFLAFVVVVFVFIEKENKIISRVSDKLKQIPQSLVDANSTDPALVLAENASLLSLSELDSAFLQLQSRLRNLSLQLGMEPAEEAEEEQTLEAEEEWEQLEPRPPAEAPPRRHVLLMATTRTGSSFVGEFFNQQGNIFYLFEPLWHIERTVSFEQGGANAAGSALVYRDVLKQLFLCDLYILEHFIIPAPEDHLTQFVFRRGSSRSLCEDPVCTPLVKKVFEKYPCKNRRCGPLNMTLAAEACRRKEHMAIKAVRIRQLEFLQPLAEDPRLDLRVIQLVRDPRAVLASRMVAFADKYETWKNWLAKGQDQLREEEVLRLKGNCESIRLSAELGLRQPAWLRGRYMLVRYEDVALRPLQKAQEMYRFAGIPLTPQVEDWIQKNTQAAHDGIYSTQKNSSEQFEKWRFSMPFKLAQVVQAACGPAMRLFGYKPVQDAASLSNRSVSLLEERGTFWVT", "length": 479, "header": "tr|E1BPN4-1|E1BPN4_BOVIN Isoform 1 of Carbohydrate sulfotransferase 3 OS=Bos taurus OX=9913 GN=CHST3 PE=3 SV=1 CANONICAL=E1BPN4-1" }, "isoforms": [ { "isoform_ac": "E1BPN4-1", "url": "https://www.uniprot.org/uniprotkb/E1BPN4/entry", "sequence": { "sequence": "MEKGLSLPQDCRHFLHSLRMRSKYALFLAFVVVVFVFIEKENKIISRVSDKLKQIPQSLVDANSTDPALVLAENASLLSLSELDSAFLQLQSRLRNLSLQLGMEPAEEAEEEQTLEAEEEWEQLEPRPPAEAPPRRHVLLMATTRTGSSFVGEFFNQQGNIFYLFEPLWHIERTVSFEQGGANAAGSALVYRDVLKQLFLCDLYILEHFIIPAPEDHLTQFVFRRGSSRSLCEDPVCTPLVKKVFEKYPCKNRRCGPLNMTLAAEACRRKEHMAIKAVRIRQLEFLQPLAEDPRLDLRVIQLVRDPRAVLASRMVAFADKYETWKNWLAKGQDQLREEEVLRLKGNCESIRLSAELGLRQPAWLRGRYMLVRYEDVALRPLQKAQEMYRFAGIPLTPQVEDWIQKNTQAAHDGIYSTQKNSSEQFEKWRFSMPFKLAQVVQAACGPAMRLFGYKPVQDAASLSNRSVSLLEERGTFWVT", "length": 479, "header": "tr|E1BPN4-1|E1BPN4_BOVIN Isoform 1 of Carbohydrate sulfotransferase 3 OS=Bos taurus OX=9913 GN=CHST3 PE=3 SV=1 CANONICAL=E1BPN4-1" }, "locus": { "chromosome": "28", "start_pos": 28097449, "end_pos": 28094539, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000014629.5", "url": "https://www.ensembl.org/id/ENSBTAT00000014629.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000014629.2", "url": "https://www.ensembl.org/id/ENSBTAP00000014629.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506758", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506758", "resource": "KEGG Pathway" }, { "id": "R-BTA-2022854", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022854", "resource": "Reactome", "description": "Keratan sulfate biosynthesis" }, { "id": "R-BTA-2022870", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022870", "resource": "Reactome", "description": "CS-GAG biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1T9E4-1", "protein_name": "Sulfotransferase", "gene_name": "CHST3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEKGFTLPQDCRHFLHSLRMRSKYALFLAFVVVVFVFIEKENKIISRVSDKLKQIPQSLVDANSTDPALVLAENASLLSLSELDSAFKQLQSRMRNLSLQLGMEPPEEAEEEEAAGAKEEEAAAEWEQEQEEPRPPAEAPPRRHVLLMATTRTGSSFVGEFFNQQGNIFYLFEPLWHIERTVSFEQGGANAAGSALVYRDVLKQLFLCDLYILEHFITPLPEDHLTQFVFRRGSSQSLCEDPVCTPLVKKVFEKYPCKNRRCGPLNMTLASEACRRKEHMAVKAVRIRQLEFLQPLAEDPRLDLRVIQLVRDPRAVLASRMVAFADKYETWKNWLAKGQDQLREEEVQRLRGNCESIRLSAELGLKQPAWLRGRYMLVRYEDVALRPLQKAQEMYRFAGIPLTPQVEDWIQKNTQAAHDGIYSTQKNSSEQFEKWRFSMPFKLAQVVQAACGPAMRLFGYKPVRDAASLSNRSVSLLEERGIFWVT", "length": 486 }, "evidence": [ { "id": "E1BPN4", "url": "https://omabrowser.org/oma/group/E1BPN4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z8N8-1", "protein_name": "Sulfotransferase", "gene_name": "CHST3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MERRSALPQDFREVLHCLKMRSKYAVLLVFVVGLVIIEKENNFISRVSDKLKQSPQVLPEANETEASPVQAENGSLASLRQLDTAFSQLRTRLRNVTLQLAGELGIAAPEPRRHVLLMATTRTGSSFVGEFFNQQGNIFYLFEPLWHIERTVTFEPGGANAVGSALVYRDVLQQLLLCDLYILESFISPAPEEHLTAALFRRGSSHSLCEEPVCTPSLKKVFEKYHCKNRRCGPLNITLAAEACRRKQHMALKTVRIRQLEFLQPLAEDPRLDLRIIQLVRDPRAVLASRMVAFSGKYESWKKWAAEGEAPLQEDEVQRLRGNCESIRLSAELGLRQPRWLRGRYMLVRYEDVARAPLRKALEMYRFAGIRPTPQVEEWIRANTQAPQDSNGIYSTQKNSSEQFEKWRFSIPFKLAQVVQDACEPAMRLFGYKLASSAQELTNRSLSLLEEGPPTRIT", "length": 458 }, "evidence": [ { "id": "E1BPN4", "url": "https://omabrowser.org/oma/group/E1BPN4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O88199-1", "protein_name": "Carbohydrate sulfotransferase 3", "gene_name": "Chst3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKGLALPQDFRDLVHSLKIRGRYVLFLAFVVIVFIFIEKENKIISRVSDKLKQIPHFVADANSTDPALLLSENASLLSLSELDSTFSHLRSRLHNLSLQLGVEPAMESQEAGAEKPSQQAGAGTRRHVLLMATTRTGSSFVGEFFNQQGNIFYLFEPLWHIERTVFFQQRGASAAGSALVYRDVLKQLLLCDLYVLEPFISPPPEDHLTQFLFRRGSSRSLCEDPVCTPFVKKVFEKYHCRNRRCGPLNVTLAGEACRRKDHVALKAVRIRQLEFLQPLVEDPRLDLRVIQLVRDPRAVLASRIVAFAGKYENWKKWLSEGQDQLSEDEVQRLRGNCESIRLSAELGLRQPAWLRGRYMLVRYEDVARRPLQKAREMYSFAGIPLTPQVEDWIQKNTQATRDSSDVYSTQKNSSEQFEKWRFSMPFKLAQVVQAACGPTMHLFGYKLARDAASLTNRSISLLEERGTFWVT", "length": 472 }, "evidence": [ { "id": "E1BPN4", "url": "https://omabrowser.org/oma/group/E1BPN4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7LGC8-1", "protein_name": "Carbohydrate sulfotransferase 3", "gene_name": "CHST3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKGLTLPQDCRDFVHSLKMRSKYALFLVFVVIVFVFIEKENKIISRVSDKLKQIPQALADANSTDPALILAENASLLSLSELDSAFSQLQSRLRNLSLQLGVEPAMEAAGEEEEEQRKEEEPPRPAVAGPRRHVLLMATTRTGSSFVGEFFNQQGNIFYLFEPLWHIERTVSFEPGGANAAGSALVYRDVLKQLFLCDLYVLEHFITPLPEDHLTQFMFRRGSSRSLCEDPVCTPFVKKVFEKYHCKNRRCGPLNVTLAAEACRRKEHMALKAVRIRQLEFLQPLAEDPRLDLRVIQLVRDPRAVLASRMVAFAGKYKTWKKWLDDEGQDGLREEEVQRLRGNCESIRLSAELGLRQPAWLRGRYMLVRYEDVARGPLQKAREMYRFAGIPLTPQVEDWIQKNTQAAHDGSGIYSTQKNSSEQFEKWRFSMPFKLAQVVQAACGPAMRLFGYKLARDAAALTNRSVSLLEERGTFWVT", "length": 479 }, "evidence": [ { "id": "E1BPN4", "url": "https://omabrowser.org/oma/group/E1BPN4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QZL2-1", "protein_name": "Carbohydrate sulfotransferase 3", "gene_name": "Chst3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEKGLALPQDCRDLVHNLKIRGRYVLFLAFVVIVFIFIEKENKIISRVSDKLKQIPQFVADANSTDPALLLSENASLLSLSELDSTFSHLRSRLHNLSLQLGIAPAMEAQGQEAVAEKPSQQAGAGTRRHVLLMATTRTGSSFVGEFFNQQGNIFYLFEPLWHIERTVFFQQGGASAAGSALVYRDVLKQLLLCDLYVLEPFISPPPEDHLTQFLFRRGSSRSLCEDPVCTPFVKKVFEKYHCRNRHCGPLNVTLAAEACRRKDHMALKVVRIRQLEFLQPLAEDPRLDLRVIQLVRDPRAVLASRMVAFAGKYESWKKWLSEGQDQLSENEVQRLRGNCENIRLSAELGLRQPAWLRGRYMLVRYEDVARRPLQKAREMYRSAGIPLTPQVEDWIQKNTQAARDSSDVYSTQKNSSEQFEKWRFSIPFKLAQVVQAVCGPAMHLFGHKLAKDTASLTNRSISLLEERGTFWVT", "length": 474 }, "evidence": [ { "id": "E1BPN4", "url": "https://omabrowser.org/oma/group/E1BPN4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "N-acetylglucosamine 6-O-sulfotransferase activity", "id": "GO:0001517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001517", "evidence": [ { "database": "UniProtKB", "id": "E1BPN4", "url": "https://www.uniprot.org/uniprotkb/E1BPN4" } ], "pmid": "" }, { "name": "chondroitin 6-sulfotransferase activity", "id": "GO:0008459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008459", "evidence": [ { "database": "UniProtKB", "id": "E1BPN4", "url": "https://www.uniprot.org/uniprotkb/E1BPN4" } ], "pmid": "" }, { "name": "keratan sulfotransferase activity", "id": "GO:0045130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045130", "evidence": [ { "database": "UniProtKB", "id": "E1BPN4", "url": "https://www.uniprot.org/uniprotkb/E1BPN4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "N-acetylglucosamine metabolic process", "id": "GO:0006044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006044", "evidence": [ { "database": "UniProtKB", "id": "E1BPN4", "url": "https://www.uniprot.org/uniprotkb/E1BPN4" } ], "pmid": "" }, { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "E1BPN4", "url": "https://www.uniprot.org/uniprotkb/E1BPN4" } ], "pmid": "" }, { "name": "sulfur compound metabolic process", "id": "GO:0006790", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006790", "evidence": [ { "database": "UniProtKB", "id": "E1BPN4", "url": "https://www.uniprot.org/uniprotkb/E1BPN4" } ], "pmid": "" }, { "name": "chondroitin sulfate proteoglycan biosynthetic process", "id": "GO:0050650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050650", "evidence": [ { "database": "UniProtKB", "id": "E1BPN4", "url": "https://www.uniprot.org/uniprotkb/E1BPN4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "E1BPN4", "url": "https://www.uniprot.org/uniprotkb/E1BPN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 259, "end_pos": 261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 420, "end_pos": 422, "annotation": "n_glycosylation_sequon" }, { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" }, { "start_pos": 63, "end_pos": 65, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11108", "name": "", "equation": "chondroitin beta-D-glucuronate + n 3'-phosphoadenylyl sulfate = chondroitin 6'-sulfate + n adenosine 3',5'-bisphosphate + n H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "11108", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11108" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPN4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 479, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPN4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPN4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 259, "end_pos": 261 }, { "start_pos": 420, "end_pos": 422 }, { "start_pos": 464, "end_pos": 466 }, { "start_pos": 63, "end_pos": 65 }, { "start_pos": 74, "end_pos": 76 }, { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPP2-1", "uniprot_ac": "E1BPP2", "uniprot_id": "E1BPP2_BOVIN", "mass": { "chemical_mass": 146450.0, "monoisotopic_mass": 146450.0 }, "refseq": { "ac": "NP_001193076", "name": "ribosome biogenesis protein BMS1 homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193076" }, "gene_names": [ { "name": "BMS1", "type": "recommended", "evidence": [ { "id": "E1BPP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP2" } ] }, { "name": "BMS1", "type": "synonym", "evidence": [ { "id": "NP_001193076", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193076" } ] } ], "protein_names": [ { "name": "BMS1 homolog, ribosome assembly protein", "type": "synonym", "evidence": [ { "id": "NP_001193076", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193076" } ] }, { "name": "BMS1 ribosome biosis factor", "type": "synonym", "evidence": [ { "id": "E1BPP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP2/entry#names_and_taxonomy" } ] }, { "name": "ribosome biogenesis protein BMS1 homolog", "type": "synonym", "evidence": [ { "id": "NP_001193076", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193076" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPP2", "url": "https://www.uniprot.org/uniprotkb/E1BPP2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BMS1", "url": "https://www.uniprot.org/uniprotkb/E1BPP2", "locus": { "chromosome": "28", "start_pos": 13229985, "end_pos": 13197801, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012878", "url": "https://www.ensembl.org/id/ENSBTAG00000012878" } ] } } ], "crossref": [ { "id": "ENSBTAG00000012878", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012878", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01882", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01882", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514945", "url": "https://www.ncbi.nlm.nih.gov/gene/514945", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012948", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012948", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037875", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037875", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514945", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514945", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BPP2", "url": "https://www.orthodb.org/?gene=E1BPP2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12858", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12858", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12858:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12858:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04950", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04950", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08142", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08142", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193076", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BPP2", "url": "https://www.uniprot.org/uniprotkb/E1BPP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPP2-1", "url": "https://www.uniprot.org/uniprotkb/E1BPP2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METKDQKKHRKKNSGPKAEKKKKRHLQDLQLGDEEDARKRNPKAFAVQSAVRMARSFHRTQDLKTKKHHIPVVDRTPLEPPPIVVVVMGPPKVGKSTLIQCLIRNFTRQKLTEIRGPVTIVSGKKRRLTIIECGCDINMMIDLAKVADLVLMLIDASFGFEMETFEFLNICQVHGFPKIMGVLTHLDSFKHNKQLKKTKKRLKHRFWTEVYPGAKLFYLSGMVHGEYQNQEIHNLGRFITVMKFRPLTWQTSHPYILADRMEDLTNPEDIRTNTKCDRKVSLYGYLRGAHLKNKSQVHIPGVGDFAVSDVSFLPDPCALPEQQKKRCLNEKEKLVYAPLSGVGGVLYDKDAVYVDLGGSHGFQESVRPTHELVQSLISTHSTIDAKMASSRVTLFSDSKPLGSEDIDNQGQWMPKEEKQVDLKTGRVRRKAIFGDEEEDESGESDDEDDEMSDGDRLENSYSDDETEEGQDAEVTDKQYMSGKGIKRQKLETEEDFEVDLPAFADSDDDLERSSVEEEAEEADESSEEEDSTAEEERDILESEAVREGGKPELLQTDDSSDSLNMEKSLTRKKATFTTSDSGHCTAEEAFASEDEPEGNSSLSTEEEDSENEEAIGKKFPKPSQVVSSQKLGSGNLIDETSDIEDLLKEEEDYKEENNYSTETSGALKWKEDLSRKAAEAFLRQQQTTPNLRKLIYGTVTEDNEEEDGDNGEELGGLFRVSQPASECKHKADSLDCSRFHVEAPHDWDLEEVMNSIRDCFVTGKWEEDKDAAKILAEDEELYGDFEDLETGDVHKGKPGPDTQIEDVEEEVKEEIDPSAEESAKKKHLDKKRKLKEMFDAEYDEGESTYFDDLKGEMQKQAQLNRAEFEDQEDEARVQYEGFRPGMYVRIEIENVPCEFVLNFDPHYPIILGGLGNSEGNVGYVQMRLKKHRWYKKILKSRDPIIFSVGWRRFQTIPLYYIEDHNGRQRLLKYTPQHMHCGATFWGPITPQGTGFLAVQSVSGSMPDFRIAATGVVLDLDKSIKIVKKLKLTGFPYKIFKNTSFIKGMFNSALEVAKFEGAVIRTVSGIRGQIKKALRAPEGAFRATFEDKLLMSDIVFMRTWYPVSIPAFYNPVTSLLKPVGEKDTWSGMRTTGQLRLAHGIKLKANKDSLYKPIVRQKKHFNSLHIPKALQKALPFKSKPKTQAKAGKTPKDRVRPAVIREPHERKILALLDALSTVHSEKMKKAKEQRHLHNKEHFKMKQKEEEEKLKRQKDLRKKLYRIQGQKERRNQKSSLKGPEEQLK", "length": 1284, "header": "tr|E1BPP2-1|E1BPP2_BOVIN Isoform 1 of BMS1 ribosome biosis factor OS=Bos taurus OX=9913 GN=BMS1 PE=3 SV=4 CANONICAL=E1BPP2-1" }, "isoforms": [ { "isoform_ac": "E1BPP2-1", "url": "https://www.uniprot.org/uniprotkb/E1BPP2/entry", "sequence": { "sequence": "METKDQKKHRKKNSGPKAEKKKKRHLQDLQLGDEEDARKRNPKAFAVQSAVRMARSFHRTQDLKTKKHHIPVVDRTPLEPPPIVVVVMGPPKVGKSTLIQCLIRNFTRQKLTEIRGPVTIVSGKKRRLTIIECGCDINMMIDLAKVADLVLMLIDASFGFEMETFEFLNICQVHGFPKIMGVLTHLDSFKHNKQLKKTKKRLKHRFWTEVYPGAKLFYLSGMVHGEYQNQEIHNLGRFITVMKFRPLTWQTSHPYILADRMEDLTNPEDIRTNTKCDRKVSLYGYLRGAHLKNKSQVHIPGVGDFAVSDVSFLPDPCALPEQQKKRCLNEKEKLVYAPLSGVGGVLYDKDAVYVDLGGSHGFQESVRPTHELVQSLISTHSTIDAKMASSRVTLFSDSKPLGSEDIDNQGQWMPKEEKQVDLKTGRVRRKAIFGDEEEDESGESDDEDDEMSDGDRLENSYSDDETEEGQDAEVTDKQYMSGKGIKRQKLETEEDFEVDLPAFADSDDDLERSSVEEEAEEADESSEEEDSTAEEERDILESEAVREGGKPELLQTDDSSDSLNMEKSLTRKKATFTTSDSGHCTAEEAFASEDEPEGNSSLSTEEEDSENEEAIGKKFPKPSQVVSSQKLGSGNLIDETSDIEDLLKEEEDYKEENNYSTETSGALKWKEDLSRKAAEAFLRQQQTTPNLRKLIYGTVTEDNEEEDGDNGEELGGLFRVSQPASECKHKADSLDCSRFHVEAPHDWDLEEVMNSIRDCFVTGKWEEDKDAAKILAEDEELYGDFEDLETGDVHKGKPGPDTQIEDVEEEVKEEIDPSAEESAKKKHLDKKRKLKEMFDAEYDEGESTYFDDLKGEMQKQAQLNRAEFEDQEDEARVQYEGFRPGMYVRIEIENVPCEFVLNFDPHYPIILGGLGNSEGNVGYVQMRLKKHRWYKKILKSRDPIIFSVGWRRFQTIPLYYIEDHNGRQRLLKYTPQHMHCGATFWGPITPQGTGFLAVQSVSGSMPDFRIAATGVVLDLDKSIKIVKKLKLTGFPYKIFKNTSFIKGMFNSALEVAKFEGAVIRTVSGIRGQIKKALRAPEGAFRATFEDKLLMSDIVFMRTWYPVSIPAFYNPVTSLLKPVGEKDTWSGMRTTGQLRLAHGIKLKANKDSLYKPIVRQKKHFNSLHIPKALQKALPFKSKPKTQAKAGKTPKDRVRPAVIREPHERKILALLDALSTVHSEKMKKAKEQRHLHNKEHFKMKQKEEEEKLKRQKDLRKKLYRIQGQKERRNQKSSLKGPEEQLK", "length": 1284, "header": "tr|E1BPP2-1|E1BPP2_BOVIN Isoform 1 of BMS1 ribosome biosis factor OS=Bos taurus OX=9913 GN=BMS1 PE=3 SV=4 CANONICAL=E1BPP2-1" }, "locus": { "chromosome": "28", "start_pos": 13229541, "end_pos": 13199400, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000048816.5", "url": "https://www.ensembl.org/id/ENSBTAT00000048816.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045796.5", "url": "https://www.ensembl.org/id/ENSBTAP00000045796.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514945", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514945", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "E1BPP2", "url": "https://www.uniprot.org/uniprotkb/E1BPP2" } ], "pmid": "" }, { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "E1BPP2", "url": "https://www.uniprot.org/uniprotkb/E1BPP2" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "E1BPP2", "url": "https://www.uniprot.org/uniprotkb/E1BPP2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "E1BPP2", "url": "https://www.uniprot.org/uniprotkb/E1BPP2" } ], "pmid": "" }, { "name": "90S preribosome", "id": "GO:0030686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030686", "evidence": [ { "database": "UniProtKB", "id": "E1BPP2", "url": "https://www.uniprot.org/uniprotkb/E1BPP2" } ], "pmid": "" }, { "name": "small-subunit processome", "id": "GO:0032040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032040", "evidence": [ { "database": "UniProtKB", "id": "E1BPP2", "url": "https://www.uniprot.org/uniprotkb/E1BPP2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000462", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000462", "evidence": [ { "database": "UniProtKB", "id": "E1BPP2", "url": "https://www.uniprot.org/uniprotkb/E1BPP2" } ], "pmid": "" }, { "name": "endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000479", "evidence": [ { "database": "UniProtKB", "id": "E1BPP2", "url": "https://www.uniprot.org/uniprotkb/E1BPP2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1041, "end_pos": 1043, "annotation": "n_glycosylation_sequon" }, { "start_pos": 105, "end_pos": 107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 293, "end_pos": 295, "annotation": "n_glycosylation_sequon" }, { "start_pos": 599, "end_pos": 601, "annotation": "n_glycosylation_sequon" }, { "start_pos": 658, "end_pos": 660, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08E00-1", "Q5E9J3-1", "A6QP66-1", "Q2KHU8-1", "Q2KIA5-1", "F1MM29-1", "P08239-1", "P04896-1", "P63097-1", "Q7YS69-1", "Q0VCJ7-1", "A0AAA9SVR8-1", "P81948-1", "Q2KJ93-1", "A0AAA9TES1-1", "P61223-1", "Q2HJB8-1", "Q0IIG7-1", "Q3ZCJ7-1", "Q27957-1", "Q2HJ86-1", "A0A3Q1LMP2-1", "F1MB25-1", "Q58DS9-1", "A0AAA9S306-1", "A0A3Q1NEF8-1", "A4FV54-1", "A6H7I5-1", "F2Z4D5-1", "G3N1U2-1", "O18956-1", "P62998-1", "Q32KN8-1", "Q3MHP2-1", "Q3T054-1", "Q3T0F5-1", "Q3T0T7-1", "Q56JV3-1", "F1MNI4-1", "Q8HZJ5-1", "P61585-1", "P62833-1", "P68103-1", "Q08DI5-1", "Q2HJH2-1", "Q2T9U1-1", "Q2TBH7-1", "Q3MHP5-1", "Q3SX43-1", "Q3SYU2-1", "P81947-1", "P84080-1", "Q08DF4-1", "Q2KI07-1", "Q2TA29-1", "Q3T0D7-1", "A6QLJ3-1", "A6QNM2-1", "A6QR46-1", "Q1LZ78-1", "Q2KHZ2-1", "G3MYK6-1", "Q58D56-1", "Q32KW9-1", "P11023-1", "Q58DW6-1", "Q9TU25-1", "P10948-1", "Q2HJI8-1", "P10949-1", "Q0IIG8-1", "Q29RR0-1", "Q32PH8-1", "Q58DS5-1", "Q1RMR4-1", "Q3ZC27-1", "P49410-1", "A0A140T898-1", "E1BPU0-1", "A0AAA9S5W8-1", "A0AAA9SLN0-1", "A0AAF6Z672-1", "Q17R06-1", "Q58D72-1", "P82922-1", "Q2HJF8-1", "Q17QU4-1", "Q2YDM7-1", "A0AAA9T9T1-1", "A0A3Q1MDX0-1", "F1N2J9-1", "Q17QB7-1", "Q3SWY9-1", "Q5E9M9-1", "A0A3S5ZPA2-1", "A0AAA9SV95-1", "A0AAA9TWE6-1", "F1N6Y7-1", "F1N7V2-1", "A0AAA9SGM6-1", "A0AAA9TNQ2-1", "A0AAA9TS74-1", "F6Q1G9-1", "A0AAF6YXF5-1", "A5D7J5-1", "P04695-1", "Q3ZBW5-1", "A4FUD1-1", "A0A3Q1M0B9-1", "A6H7F2-1", "F1MHP4-1", "A0A3Q1MGR4-1", "A0A3Q1NCE9-1", "Q0P5E2-1", "Q32LJ6-1", "Q58DC5-1", "Q08DA0-1", "A0ABI0NND0-1", "E1BJA0-1", "A0A3Q1N147-1", "A0AAF6YME1-1", "F1MX39-1", "Q1RMJ6-1", "Q2HJ68-1", "Q2HJG3-1", "Q17QI8-1", "Q3SZA1-1", "A0ABI0NZ89-1", "A0ABI0P4Y3-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A140T898", "gene_name": "RAB13", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A140T898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T898" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B9", "gene_name": "RASEF", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1M0B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDX0", "gene_name": "DNM3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDX0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDX0" } ] } ] }, { "uniprot_ac": "A0A3Q1MGR4", "gene_name": "RAB37", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1MGR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGR4" } ] } ] }, { "uniprot_ac": "A0A3Q1N147", "gene_name": "RAB1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1N147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N147" } ] } ] }, { "uniprot_ac": "A0A3Q1NCE9", "gene_name": "", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NCE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NCE9" } ] } ] }, { "uniprot_ac": "A0A3Q1NEF8", "gene_name": "RAC1", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1NEF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NEF8" } ] } ] }, { "uniprot_ac": "A0A3S5ZPA2", "gene_name": "RAB40B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPA2" } ] } ] }, { "uniprot_ac": "A0AAA9S306", "gene_name": "OPA1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S306" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": 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Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ2", "url": "https://www.uniprot.org/uniprotkb/E1BPQ2#function" }, { "database": "UniProtKB", "id": "ARBA00054292", "url": "https://www.uniprot.org/uniprotkb/ARBA00054292#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPQ2", "url": "https://www.uniprot.org/uniprotkb/E1BPQ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF335", "url": "https://www.uniprot.org/uniprotkb/E1BPQ2", "locus": { "chromosome": "13", "start_pos": 74698009, "end_pos": 74717310, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010130", "url": "https://www.ensembl.org/id/ENSBTAG00000010130" } ] } } ], "crossref": [ { "id": "ENSBTAG00000010130", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010130", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535476", "url": "https://www.ncbi.nlm.nih.gov/gene/535476", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050688", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050688", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535476", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535476", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QHMRERH", "url": "https://omabrowser.org/oma/group/QHMRERH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPQ2", "url": "https://www.orthodb.org/?gene=E1BPQ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24403", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24403", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24403:SF36", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24403:SF36", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13909", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13909", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13912", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13912", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179788", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BPQ2", "url": "https://www.uniprot.org/uniprotkb/E1BPQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPQ2-1", "url": "https://www.uniprot.org/uniprotkb/E1BPQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEENEVESSSDAAPRPGRPEEPTESGLGVGTSEAVSADSSDAAAAPGPAEADDSGVGQSSDRGSSSLEEVSESSSTTDPLPHGYLPDSSSVSRGPAAGVMGGPPALVHSSALPDPNMLVSDCTASSSDLGSAIDKIIESTIGTDLIRSCITVTSAEGSGAEATRYLILQGPDDGAPMASPMSSSTLAHSLAAIEALADGPTSTSTCLEPPEEAQGGPSSPAQPPLGSGTEEPDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPGALIAAAAGKKGRPRKWGSSAQPQEEEGPEEEDDDDIIDAGAIDDLEEDSDYNPADDEPRGRQLRAQRPTPSTLRPRRRPGRPRKLPRLETLDLPDGVEGEPLVSPQSGQSPLEPQDPEAPSSSGRGRLVALGKANRAPVEPSVSQSDARSAAASYQDEADALPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPFLCRICGSRFLSHEDLRFHVNSHEAGNPQLFRCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDKCSYTSVYRKDVIRHAAVHSRDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHASSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSTAPGPPASSPGPPEIPSEAAPSQSPETPPLLCSDTLGGATIIYQPGTAESTAVATQTALDLLLNMSTQRELGGTALQVAVVKSEDVEAGLVSSGGQPSPAGTTPQVVTLHMADPGGSVAAESQLAPPDLQQITLAPGPFGGAGYSVITAPTVEEGTSTPGTPYSEEPPGEAAQTVVVGDTLKEAGTHFIMAADGTQLHHIQLTADSSISFPSTEALASGAKWPLLQYGGLPRDGPEPPAPARTHQPRDPQGSASPPPAASKPLGLVVPPSPPSAATASSKKFSCKICAEAFTGRAEMESHKRAHAGPGAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCSQCSFASKNKKDLRRHMLTHTNEKPFECQLCGQRFNRNGHLKFHIQRLHSPDGRKTAAPTARAPARPPTQTIILNSDDETLATLHTAFQSSHGVLGPERLQQALGQEHIFVAQEQTVSNPEEAAYIQEITTADGQMVQHLVASDSQVQYIISPDGVQQLLPQEYVVVPEGHHIQVQEGQITHIQYEQGAPFLQESQIQYVPVSPGQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTEEAVPEHIQQLQHQGIEYDVITLSDD", "length": 1346, "header": "tr|E1BPQ2-1|E1BPQ2_BOVIN Isoform 1 of Zinc finger protein 335 OS=Bos taurus OX=9913 GN=ZNF335 PE=3 SV=3 CANONICAL=E1BPQ2-1" }, "isoforms": [ { "isoform_ac": "E1BPQ2-1", "url": "https://www.uniprot.org/uniprotkb/E1BPQ2/entry", "sequence": { "sequence": "MEENEVESSSDAAPRPGRPEEPTESGLGVGTSEAVSADSSDAAAAPGPAEADDSGVGQSSDRGSSSLEEVSESSSTTDPLPHGYLPDSSSVSRGPAAGVMGGPPALVHSSALPDPNMLVSDCTASSSDLGSAIDKIIESTIGTDLIRSCITVTSAEGSGAEATRYLILQGPDDGAPMASPMSSSTLAHSLAAIEALADGPTSTSTCLEPPEEAQGGPSSPAQPPLGSGTEEPDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPGALIAAAAGKKGRPRKWGSSAQPQEEEGPEEEDDDDIIDAGAIDDLEEDSDYNPADDEPRGRQLRAQRPTPSTLRPRRRPGRPRKLPRLETLDLPDGVEGEPLVSPQSGQSPLEPQDPEAPSSSGRGRLVALGKANRAPVEPSVSQSDARSAAASYQDEADALPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPFLCRICGSRFLSHEDLRFHVNSHEAGNPQLFRCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDKCSYTSVYRKDVIRHAAVHSRDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHASSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSTAPGPPASSPGPPEIPSEAAPSQSPETPPLLCSDTLGGATIIYQPGTAESTAVATQTALDLLLNMSTQRELGGTALQVAVVKSEDVEAGLVSSGGQPSPAGTTPQVVTLHMADPGGSVAAESQLAPPDLQQITLAPGPFGGAGYSVITAPTVEEGTSTPGTPYSEEPPGEAAQTVVVGDTLKEAGTHFIMAADGTQLHHIQLTADSSISFPSTEALASGAKWPLLQYGGLPRDGPEPPAPARTHQPRDPQGSASPPPAASKPLGLVVPPSPPSAATASSKKFSCKICAEAFTGRAEMESHKRAHAGPGAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCSQCSFASKNKKDLRRHMLTHTNEKPFECQLCGQRFNRNGHLKFHIQRLHSPDGRKTAAPTARAPARPPTQTIILNSDDETLATLHTAFQSSHGVLGPERLQQALGQEHIFVAQEQTVSNPEEAAYIQEITTADGQMVQHLVASDSQVQYIISPDGVQQLLPQEYVVVPEGHHIQVQEGQITHIQYEQGAPFLQESQIQYVPVSPGQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTEEAVPEHIQQLQHQGIEYDVITLSDD", "length": 1346, "header": "tr|E1BPQ2-1|E1BPQ2_BOVIN Isoform 1 of Zinc finger protein 335 OS=Bos taurus OX=9913 GN=ZNF335 PE=3 SV=3 CANONICAL=E1BPQ2-1" }, "locus": { "chromosome": "13", "start_pos": 74716421, "end_pos": 74698320, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061303.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061303.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053387.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053387.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 201, "start_aa": "Thr", "end_pos": 201, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr201", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 345, "start_aa": "Thr", "end_pos": 345, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr345", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 560, "start_aa": "Thr", "end_pos": 560, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr560", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:535476", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535476", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7H3T4-1", "protein_name": "Zinc finger protein 335 isoform X1", "gene_name": "Znf335", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEENEVESSSDAAPRPGQPEEPSESGLGVGTSEAVSADSSDAAAAPGLTEADDSGVGQSSDSGSRSVEEVSESISTDALPHGYLPDSSSVSRGTVAEVPGGPPALVHSSVLPDPSLLVSDCTASSSDLGAAIDKIIESTIGPDLIQRCITVTSAEEGGAETTQYLILQGPDDGAPMTSPMSTSTLVNSLSAIETVADGPTSTSTCLEPPEEPQGEHSSAAQPLPACGPDELELQSLEALMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPAATAAAAGKRGRLRKWGTSTHKTTEEEGPEDEEEEEDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPRLETADFYDGVAEPLVSSQSTQSSPELQDLEAPSSSGPGCLWGKMGRGPVESGVSQSDAENAAHSCKDEPDVPPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPYLCRICGSRFLSLEDLRFHVNSHEAGDPQLFKCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSRDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVAHRRFKCEFCEFVCDDKKALLNHQLSHVSDKPFRCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPEDPPSRRRPFFSVQQIEELKQQHTGAPGLPSSAPGPQVPQEPAPFQSPETPPLLCPDALSGATIIYQQGAEESTAMATQTALDLLLNMSSQRELGATALQVAVVKSEGMEAELTSTGRQPSPEDTTPQVVTLHVGEPGSSLAAESQLGPSDLQQIALPSGSFGGASYSVITAPPLEERTSAPGTSYRPPPSALSEEPPGEAAQTVVVSDSLKEAGTHYIMAADGTQLHHIELTADGSISFPSPDTLASGTKWPLLQCEGPPRNGPEVISPLKTHHVEGPQGSPTPPPATSNTVGLVVPTSPPSAAALSAKKFSCKVCSEAFAGRAEMESHKRAHAGPAAFKCPDCPFHARQWPEVRAHMAQHSSLRPHQCNQCSFASKNKKDLRRHMLTHTNEKPFSCHLCGQRFNRNGHLKFHIQRLHSSDGRKTGASTARAPAQTIILNSEEETLATLHTALQSSHGVLGPERLQQALSQEHIFVAQEQTVTNQEEAAYIQEITTADGQTVQHLVTNDNQVQYIIAQDGVQHLLPQEYVVVPDGHHIQLPTSRSRKARSHTSSMSKVPHSCRSPRSSMFLCPQASSLLPRLSLRLQHILLLQRWPMLPWPKPRACLALRRQCLNTSNSCNTRASSTTSLPSRMTEPQRPNADLGYRGQLSWRLGTFLSYLGPPDTGQSVSLDSKGARPVLLWGSHGPQPGHAGYLSLLAGFGREVYFCLDGPTGSSVSIKGPESSPCSSLCTWC", "length": 1451 }, "evidence": [ { "id": "E1BPQ2", "url": "https://omabrowser.org/oma/group/E1BPQ2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A2A5K6-1", "protein_name": "Zinc finger protein 335", "gene_name": "Znf335", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEENEVESSSDAAPRPGQPEEPSESGLGVCTSEAVSADSSDAATVPGLTEADDSGVGQSSDGGNHSVEEVSESISTDPLPHGCLPDSSSVSRGPVAEMPGGPPALVHSSVLPDPSMLVSDCTASSSDLGSAIDKIIESTIGPDLIQSCITVTSGEEGGAETTQYLILQGPDDGAPMASSMSTSTLANSLAAIEALADGPTSTSACLEPPEEPQGDPSSVAQQPPAPVTEELDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPALAAAAAATGKRGRVRKWGTSTKTTEEDRPEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPRLETSDLHDGVGQPLVSSQSTQSPPELQDLEAPSSSGLRALGKVGRGLVESGVSQSDAENAAPSCQDEADAPPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFRCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSTAPGPPLSSPGPEAPQEPAPFQSPETPPLLCPDALGGTTIIYQQGAEESTAVATQTALDLLLNMSAQRELGATALQVAVVKSEGIEAELTSTGGQPSPEDTTPRVVTLHMAESGSSVAAESQLGPSDLQQIALPSGPFGGASYSVITAPPVEGRTSASGPPYREEPPGEAAQAVVVSDTLKEAGTHYIMAADGTQLHHIELTADGSISFPSPDTLAPGTKWPLLQCGGPPRDGSEVLSPTKTHHMGGSQGSSTPPPAASHTLGLVVPQSPPSAAASSTKKFSCKVCSEAFPSRAEMESHKRAHAGPAAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCNQCSFASKNKKDLRRHMLTHTNEKPFSCHVCGQRFNRNGHLKFHIQRLHSIDGRKTGTSTARAPAQTIILNSEEETLATLHTAFQSSHGVLGTERLQQALSQEHIIVAQEQTVTNQEEATYIQEITADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPDGHHIQVQEGQITHIQYEQGTPFLQESQIQYVPVSPSQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTEEAVPEQIHQLQHQGIEYDVITLSDD", "length": 1337 }, "evidence": [ { "id": "E1BPQ2", "url": "https://omabrowser.org/oma/group/E1BPQ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G3V893-1", "protein_name": "Zinc finger protein 335", "gene_name": "Znf335", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEENEVESSSDAAPRPGQPEEPSESGLGVGTSEAVSADSTDAATAPGLTEADDSGVGQSSDSGSRSVEEVSESISTEPLPQGYLPDSSSVSRGPVAEVPGGPPALVHSSALPDPSMLVSDCTASSSDLGSAIDKIIESTIGPDLIQSCITVTSGEEGGAETTQYLILQGPDDGAPMASSMSTSTLANSLAAIEALADGPTSTSTCLEPAEQPPGEPSSLAQPPAPVVEELDLQGLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPALAVAAAAAGKRGRVRKWGTSTKTTEEEGPEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTLRPRRRPGRPRKLPRLETSDLHDGIGEPLVSSQSTQSPPELQDLEAPSSSDLRALGKVGRGLVETGVSQSDAENAAPSCQDEADVPPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSAAPGPPLSSAGPEAPQEPAPFQPPETPPLLCPDALGGATIIYQQGAEESTAMATQTALDLLLNMSAQRELGATALQVAVVKSEDVEAELTSTARQPSSEDTTPRVVTLHVAESGSSVAAESQLGPSDLQQIALPPGPFSGASYSVITAPPVEGRASASGPPYREEPPGEAAQAVVVNDTLKEAGTHYIMAADGTQLHHIELTADGSISFPSPDTLAPGTKWPLLQCGGPPRDGPEVLSPTKTHHTGGSQGSSTPPPATSHALGLLVPHSPPSAAASSTKKFSCKVCSEAFPSRAEMESHKRAHAGPAAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCNQCSFASKNKKDLRRHMLTHTNEKPFSCHVCGQRFNRNGHLKFHIQRLHSIDGRKTGTSTARAPAQTIILNSEEETLATLHTAFQSNHGTLGTERLQQALSQEHIIVAQEQTVANQEEATYIQEITADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPDGHHIQVQEGQITHIQYEQGTPFLQESQIQYVPVSPSQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTEEAVPEHIQQLQHQGIEYDVITLSDD", "length": 1336 }, "evidence": [ { "id": "E1BPQ2", "url": "https://omabrowser.org/oma/group/E1BPQ2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9H4Z2-1", "protein_name": "Zinc finger protein 335", "gene_name": "ZNF335", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEENEVESSSDAAPGPGRPEEPSESGLGVGTSEAVSADSSDAAAAPGQAEADDSGVGQSSDRGSRSQEEVSESSSSADPLPNSYLPDSSSVSHGPVAGVTGGPPALVHSSALPDPNMLVSDCTASSSDLGSAIDKIIESTIGPDLIQNCITVTSAEDGGAETTRYLILQGPDDGAPMTSPMSSSTLAHSLAAIEALADGPTSTSTCLEAQGGPSSPVQLPPASGAEEPDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPVAAAAAAAGKKGRLRKWSTSTKSQEEEGPEEEDDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPRLEISDLPDGVEGEPLVSSQSGQSPPEPQDPEAPSSSGPGHLVAMGKVSRTPVEAGVSQSDAENAAPSCPDEHDTLPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPFLCRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSRDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHASSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSAAPGPPPSSPGPPEIPPEATTFQSSEAPSLLCSDTLGGATIIYQQGAEESTAMATQTALDLLLNMSAQRELGGTALQVAVVKSEDVEAGLASPGGQPSPEGATPQVVTLHVAEPGGGAAAESQLGPPDLPQITLAPGPFGGTGYSVITAPPMEEGTSAPGTPYSEEPAGEAAQAVVVSDTLKEAGTHYIMATDGTQLHHIELTADGSISFPSPDALASGAKWPLLQCGGLPRDGPEPPSPAKTHCVGDSQSSASSPPATSKALGLAVPPSPPSAATAASKKFSCKICAEAFPGRAEMESHKRAHAGPGAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCSQCSFASKNKKDLRRHMLTHTKEKPFACHLCGQRFNRNGHLKFHIQRLHSPDGRKSGTPTARAPTQTPTQTIILNSDDETLATLHTALQSSHGVLGPERLQQALSQEHIIVAQEQTVTNQEEAAYIQEITTADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPEGHHIQVQEGQITHIQYEQGAPFLQESQIQYVPVSPGQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTDETVPEHIQQLQHQGIEYDVITLADD", "length": 1342 }, "evidence": [ { "id": "E1BPQ2", "url": "https://omabrowser.org/oma/group/E1BPQ2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ2", "url": "https://www.uniprot.org/uniprotkb/E1BPQ2" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ2", "url": "https://www.uniprot.org/uniprotkb/E1BPQ2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ2", "url": "https://www.uniprot.org/uniprotkb/E1BPQ2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ2", "url": "https://www.uniprot.org/uniprotkb/E1BPQ2" } ], "pmid": "" }, { "name": "histone methyltransferase complex", "id": "GO:0035097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035097", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ2", "url": "https://www.uniprot.org/uniprotkb/E1BPQ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BPQ2", "url": "https://www.uniprot.org/uniprotkb/E1BPQ2" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": 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"XP_005217702", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217702" } ] }, { "name": "WBSCR17", "type": "synonym", "evidence": [ { "id": "XP_005217702", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217702" } ] } ], "protein_names": [ { "name": "Polypeptide N-acetylgalactosaminyltransferase", "type": "recommended", "evidence": [ { "id": "E1BPR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPR6/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.-", "type": "synonym", "evidence": [ { "id": "E1BPR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPR6/entry#names_and_taxonomy" } ] }, { "name": "Protein-UDP acetylgalactosaminyltransferase", "type": "synonym", "evidence": [ { "id": "E1BPR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPR6/entry#names_and_taxonomy" } ] }, { "name": "polypeptide N-acetylgalactosaminyltransferase 9 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005217702", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217702" } ] } ], "function": [ { "annotation": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3.", "evidence": [ { "database": "UniProtKB", "id": "E1BPR6", "url": "https://www.uniprot.org/uniprotkb/E1BPR6#function" }, { "database": "UniProtKB", "id": "ARBA00057231", "url": "https://www.uniprot.org/uniprotkb/ARBA00057231#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPR6", "url": "https://www.uniprot.org/uniprotkb/E1BPR6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GALNT9", "url": "https://www.uniprot.org/uniprotkb/E1BPR6", "locus": { "chromosome": "17", "start_pos": 44939628, "end_pos": 44854047, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005644", "url": "https://www.ensembl.org/id/ENSBTAG00000005644" } ] } } ], "crossref": [ { "id": "E1BPR6", "url": "https://alphafold.ebi.ac.uk/entry/E1BPR6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005644", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005644", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02510", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02510", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504951", "url": "https://www.ncbi.nlm.nih.gov/gene/504951", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001173", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001173", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "E1BPR6", "url": "https://www.orthodb.org/?gene=E1BPR6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11675", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11675", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11675:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11675:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00535", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00535", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00652", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00652", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-913709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005217702", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217702", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "23956", "url": "https://www.rhea-db.org/rhea/23956", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "52424", "url": "https://www.rhea-db.org/rhea/52424", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E1BPR6", "url": "https://www.uniprot.org/uniprotkb/E1BPR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPR6-1", "url": "https://www.uniprot.org/uniprotkb/E1BPR6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVARKIKTLLTVNILVFVGIILFSVYCRLQDRSEGLVQIVRSADRRVRSRHAKVGALAEREAILQRLDHLEEVVYNQLNGLAKPIGLVEGPGGLGQGGMAATLRDDSQETEGKFEEYGYNAQLSDRISLDRTIPDYRPKKCRQMTYSDDLPQISVVFIFVNEALSVILRSVHSVVNHTPSQLLKEVILVDDNSDNVELKLNLDQYVSKRYPGLVKIVRNSRREGLIRARLQGWKVATAPVVGFFDAHVEFSTGWAEPALTRIREDRRRIVLPAIDNIKYDTFEVQQYASAAHGYNWGLWCMYIVPPQDWLDRGDEAAPIRTPAMIGCSFVVDREYFGDIGLLDPGMEVYGGENIELGMRVWQCGGSMEVLPCSRVAHIERTKKPYNNDIDYYAKRNALRAAEVWMDGFKSHVYMAWNIPMTNPGVDFGDVSERLALRQRLKCRSFKWYLDNVYPEMRTYNDTLTYGEVRNSKASGYCLDQGAEDDDRAILYPCHGMSSQLVRYSAEGLLQLGPLGSTAFLPDSKCLVDDGRGRTPALKKCEDVARPAQRLWDFTQGGPIVSRDTGRCLEVEMSKDANFGLRLVVQRCSGQKWTIRNWIKPGRH", "length": 604, "header": "tr|E1BPR6-1|E1BPR6_BOVIN Isoform 1 of Polypeptide N-acetylgalactosaminyltransferase OS=Bos taurus OX=9913 GN=GALNT9 PE=3 SV=3 CANONICAL=E1BPR6-1" }, "isoforms": [ { "isoform_ac": "E1BPR6-1", "url": "https://www.uniprot.org/uniprotkb/E1BPR6/entry", "sequence": { "sequence": "MAVARKIKTLLTVNILVFVGIILFSVYCRLQDRSEGLVQIVRSADRRVRSRHAKVGALAEREAILQRLDHLEEVVYNQLNGLAKPIGLVEGPGGLGQGGMAATLRDDSQETEGKFEEYGYNAQLSDRISLDRTIPDYRPKKCRQMTYSDDLPQISVVFIFVNEALSVILRSVHSVVNHTPSQLLKEVILVDDNSDNVELKLNLDQYVSKRYPGLVKIVRNSRREGLIRARLQGWKVATAPVVGFFDAHVEFSTGWAEPALTRIREDRRRIVLPAIDNIKYDTFEVQQYASAAHGYNWGLWCMYIVPPQDWLDRGDEAAPIRTPAMIGCSFVVDREYFGDIGLLDPGMEVYGGENIELGMRVWQCGGSMEVLPCSRVAHIERTKKPYNNDIDYYAKRNALRAAEVWMDGFKSHVYMAWNIPMTNPGVDFGDVSERLALRQRLKCRSFKWYLDNVYPEMRTYNDTLTYGEVRNSKASGYCLDQGAEDDDRAILYPCHGMSSQLVRYSAEGLLQLGPLGSTAFLPDSKCLVDDGRGRTPALKKCEDVARPAQRLWDFTQGGPIVSRDTGRCLEVEMSKDANFGLRLVVQRCSGQKWTIRNWIKPGRH", "length": 604, "header": "tr|E1BPR6-1|E1BPR6_BOVIN Isoform 1 of Polypeptide N-acetylgalactosaminyltransferase OS=Bos taurus OX=9913 GN=GALNT9 PE=3 SV=3 CANONICAL=E1BPR6-1" }, "locus": { "chromosome": "17", "start_pos": 44968136, "end_pos": 44854435, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061536.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061536.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053374.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053374.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-913709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "resource": "Reactome", "description": "O-linked glycosylation of mucins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "E1BPR6", "url": "https://www.uniprot.org/uniprotkb/E1BPR6" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "E1BPR6", "url": "https://www.uniprot.org/uniprotkb/E1BPR6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein O-linked glycosylation", "id": "GO:0006493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006493", "evidence": [ { "database": "UniProtKB", "id": "E1BPR6", "url": "https://www.uniprot.org/uniprotkb/E1BPR6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "E1BPR6", "url": "https://www.uniprot.org/uniprotkb/E1BPR6" } ], "pmid": "" }, { "name": "polypeptide N-acetylgalactosaminyltransferase activity", "id": "GO:0004653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004653", "evidence": [ { "database": "UniProtKB", "id": "E1BPR6", "url": "https://www.uniprot.org/uniprotkb/E1BPR6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 461, "end_pos": 463, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23956", "name": "", "equation": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M986-1", "Q07537-1", "Q5EA41-1", "A0AAA9TS02-1", "A0AAA9S1Y7-1", "F1N554-1", "E1BDW8-1", "E1BHN6-1", "A0AAA9S5W3-1", "E1B9U7-1", "A0AAA9T153-1", "A0A3Q1N2Q7-1", "E1BPR6-1" ], "evidence": [ { "id": "23956", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23956" } ] }, { "id": "52424", "name": "", "equation": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M986-1", "Q07537-1", "Q5EA41-1", "A0AAA9TS02-1", "A0AAA9S1Y7-1", "F1N554-1", "E1BDW8-1", "E1BHN6-1", "A0AAA9S5W3-1", "E1B9U7-1", "A0AAA9T153-1", "A0A3Q1N2Q7-1", "E1BPR6-1" ], "evidence": [ { "id": "52424", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52424" } ] }, { "id": "R-BTA-913675", "name": "GALNTs transfer GalNAc to Mucins to form Tn antigens", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [ "R-ALL-9942384" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1M986-1", "Q07537-1", "E1BDW8-1", "E1BHN6-1", "A0AAA9T153-1", "F1N554-1", "F6QA59-1", "F6RJ62-1", "A0AAA9S1Y7-1", "E1BPR6-1", "E1B9U7-1", "A0AAA9S5W3-1", "E1BKQ9-1" ], "evidence": [ { "id": "R-BTA-913675", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913675" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-9942384", "participant_name": "UDP-GalNAc [Golgi lumen]", "crossref": [ { "id": "67138", "database": "ChEBI", "url": "" }, { "id": "ZINC000008551132", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1M986", "gene_name": "GALNT2", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0A3Q1M986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M986" } ] } ] }, { "uniprot_ac": "A0A3Q1N2Q7", "gene_name": "GALNT12", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0A3Q1N2Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2Q7" } ] } ] }, { "uniprot_ac": "A0AAA9S1Y7", "gene_name": "GALNT14", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9S1Y7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Y7" } ] } ] }, { "uniprot_ac": "A0AAA9S5W3", "gene_name": "GALNT3", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9S5W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5W3" } ] } ] }, { "uniprot_ac": "A0AAA9T153", "gene_name": "GALNT7", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9T153", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T153" } ] } ] }, { "uniprot_ac": "A0AAA9TS02", "gene_name": "GALNTL6", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9TS02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS02" } ] } ] }, { "uniprot_ac": "E1B9U7", "gene_name": "GALNT17", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1B9U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9U7" } ] } ] }, { "uniprot_ac": "E1BDW8", "gene_name": "GALNT11", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1BDW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDW8" } ] } ] }, { "uniprot_ac": "E1BHN6", "gene_name": "GALNT15", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1BHN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHN6" } ] } ] }, { "uniprot_ac": "E1BKQ9", "gene_name": "GALNT5", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1BKQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKQ9" } ] } ] }, { "uniprot_ac": "E1BPR6", "gene_name": "GALNT9", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "E1BPR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPR6" } ] } ] }, { "uniprot_ac": "F1N554", "gene_name": "GALNT10", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F1N554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N554" } ] } ] }, { "uniprot_ac": "F6QA59", "gene_name": "GALNT8", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F6QA59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QA59" } ] } ] }, { "uniprot_ac": "F6RJ62", "gene_name": "GALNT18", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F6RJ62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RJ62" } ] } ] }, { "uniprot_ac": "Q07537", "gene_name": "GALNT1", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q07537", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07537" } ] }, { "ec_number": "2.4.1.41", "activity": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+).", "evidence": [ { "id": "Q07537", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07537" } ] }, { "ec_number": "2.4.1.41", "activity": "", "evidence": [ { "id": "Q07537", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q07537" } ] } ] }, { "uniprot_ac": "Q5EA41", "gene_name": "GALNT6", "activity": [ { "ec_number": "2.4.1.41", "activity": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+).", "evidence": [ { "id": "Q5EA41", "database": 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Classification" ] }, { "id": "E1BPS3", "url": "https://www.orthodb.org/?gene=E1BPS3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1N6Q9", "url": "https://www.orthodb.org/?gene=F1N6Q9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46108", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46108", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46108:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46108:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01363", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01363", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02138", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02138", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14844", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14844", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23295", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23295", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "E1BPS3", "url": "https://www.uniprot.org/uniprotkb/E1BPS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPS3-1", "url": "https://www.uniprot.org/uniprotkb/E1BPS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Q9", "url": "https://www.uniprot.org/uniprotkb/F1N6Q9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1N6Q9-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Q9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNMVKRIMGRPRQEECSPQDNALGLMHLRRLFTELCHPPRHMTQKEQEEKLYMMLPVFNRVFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKSTEAASRAIVQFLEINQSEEASRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKCLYLFFDLPHVPEAVGGAQNELPLAERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLLFSAITSWCPPYNLPWRKSAGEVLMTISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSPLEIVEMFAGLSCFLKDSSDVSQTLLDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKDLVNLITSLTTYGVNELKPAGITTGAPFLLPGFAVPQPAGKGHSVRNIQAFAVLQNAFLKAKTNFLAHIILDAITNIYMADNANYFILESQHTLSQFAEKISKLPEVQNKYFEMLEFVVFSLNYIPCKELISVSILLKSSSSYHCSIIAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLLHKYAALLKDPTQALNEQGDSRNNSSFEDQKHLALLVMETLTVLLQGSNTNAGIFREFGGARCAHNIVRYPQCRQHALMMIQQLVLSPNGDDDMGTLLGLMHSAPPTELQLKTDILRALLSVLRESHRSRTVFRKVGGFVYVTSLLVAMERSLSAPPKNGWEKVSQGHVFELLHTVFCTLTAAMRYEPANSHFFKTEIQYEKLADAVRFLGCFSDLRKISPMNVFPSNTQPFQRLLEEDVISMDSVSPTLRHCSKLFIYLYRVATDSFDRHAYHSVSTPPVYPPKNVADLKPHVATSSLSSSDAVIIHPGAMLAMLDLLASVGSVTQPEHALDLQLAVANILQSLVHTERNQQVMCEAGLHARLLQRCSAALADEDHSLHPPLQRMFERLASQALEPMVLREFLRLASPLNCGAWDKKLLKQYRVHKPSSLSFEPEMRSSMITSMEGLGSDNVFSLHEDNHYRISKSLVKSAEGSTVPLTRVKCLVSMTTPHDIRLHGSSVTPAFVEFDTSLEGFGCLFLPSLAPHNAPTNNAVTTGLIDGAVVSGIGSGERFFPPPSGLSYSSWFCIEHFSSPPSNHPVRLLTVVRRANSSEHHYVCLAIVLSAKDRSLIVSTKEELLQNYVDDFSEESSFYEILPCCARFRCGELIVEGQWHHLVLVMSKGMLKNSTATLYIDGQLVSTVKLHYVHSTPGGSGSANPPVVSTVYAYIGTPPAQRQIASLVWRLGPTHFLEEVLPPSNVTTIYELGPNYVGSFQAVCMPCKDAKSEGVVPSPVSLVPEEKVSFGLYALSVSALTVARIRKVYNKLDSKAIAKQLGISSHENATPVKLIHNSAGHLNGPARTIGASLIGYLGVRTFVPKPVATTLQYVGGAAAILGLVAMASDVEGLYAAVKALVCVVKSNPLASKEMERIRGYQLLAMLFKKKRSLLNSHILHLTFSLVGTVDSGHETSIIPNSTAFQDLLCDFEVWLHAPYELHLSLFEHFIELLTESSEASKNAKLMREFQLIPKLLLTLRDMSLSQPTIAAISNVLSFLLQGFPNSNDLLRFGQFISSTLPTFAVCEKFVVMEINHEEKPDTGTEEEFGGLVSANLILLRNRLLDILLKLVYTSKEKTSINLQACEELVRTLGFDWIMMFMEEHLHSTTVTAAMRILVVLLSNQSILIKFKEGLSGGGWLEQTDSVLTNKIGTVLGFNVGRSAGGRSTVREINRDACHFPGFPVLQSFLPKHTNVPALYFLLMALFLQQPVSELPENLQVSVPVVSSRCKQGCQFDLDSIWTFIFGVPASSGTVVSSIHNVCTEAAFLLLGMLRSMLNSPWQSEEEGSWLREYPVTLMQFFRYLYHNVPDLASMWMNPDFLCALAATVFPFNIRPYSEMVTDLDDEVGSPAEEFKAFAADTGMNRSQSEYCNVGVKTYLTNHPAKKFVFDFMRVLIIDNLCLTPASKQTPLIDLLLEASPERSTRTQQKEFQTYILDSVMDHLLAADVLLGEDASLPITSGGSYQVLVNNVFYFTQRVVDKLWQGMFNKESKLLIDFIIQLIAQSKRRSQGLSLDAVYHCLNRTILYQFSRAHKTVPQQVALLDSLRVLTVNRNLILGPGNHDQEFISCLAHCLINLHVGSNVDGFGLEAEARMTTWHIMIPSDIEPDGGYSQDISEGRQLLIKAVNRVWTELIHSKKQVLEELFKVTLPVNERGHVDIAIARPLIEEASLKCWQNHLAHEKKCISRGEALMPTTQSKLSRVSSGFGLSKLTGSRRNRKESGLHKHSLSTQEISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYVTEEWCQIEYELLRERGLWGPPIGSHLDKWMLEMTEGPCRMRKKMVRNDMFYNHYPYVPEMEQETNVASEIPSKQPETPDDIIPQKKPARYRRAVSYDSKEYYMRLASGNPAIVQDAIVESSEGEAAQQEPEHGEDTIAKVKGLVKPPLKRSRSAPDGGDEETQEQLQDQTAEGSSIEEEEKTDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFGKEHFYVIDGFTMTATREIRDIETLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPSLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSRLNGDNAGASVPPGSASDKIFFHHLDNLRPSLTPVKELKEPVGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKAVTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVWEMSTSKEKAKTLTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINELTGDIVSCAGTYIHVWSINGNPVVSVNTFTGRSQQIVCCCVSEMNEWDTQNVIVTGHSDGVVRFWRMEFLQVPETPAPEPAEVLEMQEDCPEAQIGQEAQDEDSSDSEADEQSVSQDPKDTPSQPSSTSHRPRAASCRATATWYNDSGSDDSRRWSDQLSLDEKDGFIFVNYSEGQSRPHLQTPLNHPHPNPIEARNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPAEITALGVSKDHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHERSSEDGPRNC", "length": 3499, "header": "tr|E1BPS3-1|E1BPS3_BOVIN Isoform 1 of WD repeat and FYVE domain-containing protein 3 OS=Bos taurus OX=9913 GN=WDFY3 PE=4 SV=4 CANONICAL=E1BPS3-1" }, "isoforms": [ { "isoform_ac": "E1BPS3-1", "url": "https://www.uniprot.org/uniprotkb/E1BPS3/entry", "sequence": { "sequence": "MNMVKRIMGRPRQEECSPQDNALGLMHLRRLFTELCHPPRHMTQKEQEEKLYMMLPVFNRVFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKSTEAASRAIVQFLEINQSEEASRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKCLYLFFDLPHVPEAVGGAQNELPLAERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLLFSAITSWCPPYNLPWRKSAGEVLMTISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSPLEIVEMFAGLSCFLKDSSDVSQTLLDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKDLVNLITSLTTYGVNELKPAGITTGAPFLLPGFAVPQPAGKGHSVRNIQAFAVLQNAFLKAKTNFLAHIILDAITNIYMADNANYFILESQHTLSQFAEKISKLPEVQNKYFEMLEFVVFSLNYIPCKELISVSILLKSSSSYHCSIIAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLLHKYAALLKDPTQALNEQGDSRNNSSFEDQKHLALLVMETLTVLLQGSNTNAGIFREFGGARCAHNIVRYPQCRQHALMMIQQLVLSPNGDDDMGTLLGLMHSAPPTELQLKTDILRALLSVLRESHRSRTVFRKVGGFVYVTSLLVAMERSLSAPPKNGWEKVSQGHVFELLHTVFCTLTAAMRYEPANSHFFKTEIQYEKLADAVRFLGCFSDLRKISPMNVFPSNTQPFQRLLEEDVISMDSVSPTLRHCSKLFIYLYRVATDSFDRHAYHSVSTPPVYPPKNVADLKPHVATSSLSSSDAVIIHPGAMLAMLDLLASVGSVTQPEHALDLQLAVANILQSLVHTERNQQVMCEAGLHARLLQRCSAALADEDHSLHPPLQRMFERLASQALEPMVLREFLRLASPLNCGAWDKKLLKQYRVHKPSSLSFEPEMRSSMITSMEGLGSDNVFSLHEDNHYRISKSLVKSAEGSTVPLTRVKCLVSMTTPHDIRLHGSSVTPAFVEFDTSLEGFGCLFLPSLAPHNAPTNNAVTTGLIDGAVVSGIGSGERFFPPPSGLSYSSWFCIEHFSSPPSNHPVRLLTVVRRANSSEHHYVCLAIVLSAKDRSLIVSTKEELLQNYVDDFSEESSFYEILPCCARFRCGELIVEGQWHHLVLVMSKGMLKNSTATLYIDGQLVSTVKLHYVHSTPGGSGSANPPVVSTVYAYIGTPPAQRQIASLVWRLGPTHFLEEVLPPSNVTTIYELGPNYVGSFQAVCMPCKDAKSEGVVPSPVSLVPEEKVSFGLYALSVSALTVARIRKVYNKLDSKAIAKQLGISSHENATPVKLIHNSAGHLNGPARTIGASLIGYLGVRTFVPKPVATTLQYVGGAAAILGLVAMASDVEGLYAAVKALVCVVKSNPLASKEMERIRGYQLLAMLFKKKRSLLNSHILHLTFSLVGTVDSGHETSIIPNSTAFQDLLCDFEVWLHAPYELHLSLFEHFIELLTESSEASKNAKLMREFQLIPKLLLTLRDMSLSQPTIAAISNVLSFLLQGFPNSNDLLRFGQFISSTLPTFAVCEKFVVMEINHEEKPDTGTEEEFGGLVSANLILLRNRLLDILLKLVYTSKEKTSINLQACEELVRTLGFDWIMMFMEEHLHSTTVTAAMRILVVLLSNQSILIKFKEGLSGGGWLEQTDSVLTNKIGTVLGFNVGRSAGGRSTVREINRDACHFPGFPVLQSFLPKHTNVPALYFLLMALFLQQPVSELPENLQVSVPVVSSRCKQGCQFDLDSIWTFIFGVPASSGTVVSSIHNVCTEAAFLLLGMLRSMLNSPWQSEEEGSWLREYPVTLMQFFRYLYHNVPDLASMWMNPDFLCALAATVFPFNIRPYSEMVTDLDDEVGSPAEEFKAFAADTGMNRSQSEYCNVGVKTYLTNHPAKKFVFDFMRVLIIDNLCLTPASKQTPLIDLLLEASPERSTRTQQKEFQTYILDSVMDHLLAADVLLGEDASLPITSGGSYQVLVNNVFYFTQRVVDKLWQGMFNKESKLLIDFIIQLIAQSKRRSQGLSLDAVYHCLNRTILYQFSRAHKTVPQQVALLDSLRVLTVNRNLILGPGNHDQEFISCLAHCLINLHVGSNVDGFGLEAEARMTTWHIMIPSDIEPDGGYSQDISEGRQLLIKAVNRVWTELIHSKKQVLEELFKVTLPVNERGHVDIAIARPLIEEASLKCWQNHLAHEKKCISRGEALMPTTQSKLSRVSSGFGLSKLTGSRRNRKESGLHKHSLSTQEISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYVTEEWCQIEYELLRERGLWGPPIGSHLDKWMLEMTEGPCRMRKKMVRNDMFYNHYPYVPEMEQETNVASEIPSKQPETPDDIIPQKKPARYRRAVSYDSKEYYMRLASGNPAIVQDAIVESSEGEAAQQEPEHGEDTIAKVKGLVKPPLKRSRSAPDGGDEETQEQLQDQTAEGSSIEEEEKTDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFGKEHFYVIDGFTMTATREIRDIETLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPSLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSRLNGDNAGASVPPGSASDKIFFHHLDNLRPSLTPVKELKEPVGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKAVTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVWEMSTSKEKAKTLTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINELTGDIVSCAGTYIHVWSINGNPVVSVNTFTGRSQQIVCCCVSEMNEWDTQNVIVTGHSDGVVRFWRMEFLQVPETPAPEPAEVLEMQEDCPEAQIGQEAQDEDSSDSEADEQSVSQDPKDTPSQPSSTSHRPRAASCRATATWYNDSGSDDSRRWSDQLSLDEKDGFIFVNYSEGQSRPHLQTPLNHPHPNPIEARNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPAEITALGVSKDHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHERSSEDGPRNC", "length": 3499, "header": "tr|E1BPS3-1|E1BPS3_BOVIN Isoform 1 of WD repeat and FYVE domain-containing protein 3 OS=Bos taurus OX=9913 GN=WDFY3 PE=4 SV=4 CANONICAL=E1BPS3-1" }, "locus": { "chromosome": "6", "start_pos": 99723220, "end_pos": 99508635, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061443.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061443.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053365.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053365.4" } ] } }, { "isoform_ac": "F1N6Q9-1", "url": "https://www.uniprot.org/uniprotkb/F1N6Q9/entry", "sequence": { "sequence": "MNMVKRIMGRPRQEECSPQDNALGLMHLRRLFTELCHPPRHMTQKEQEEKLYMMLPVFNRVFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKSTEAASRAIVQFLEINQSEEASRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKCLYLFFDLPHVPEAVGGAQNELPLAERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLLFSAITSWCPPYNLPWRKSAGEVLMTISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSPLEIVEMFAGLSCFLKDSSDVSQTLLDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKDLVNLITSLTTYGVNELKPAGITTGAPFLLPGFAVPQPAGKGHSVRNIQAFAVLQNAFLKAKTNFLAHIILDAITNIYMADNANYFILESQHTLSQFAEKISKLPEVQNKYFEMLEFVVFSLNYIPCKELISVSILLKSSSSYHCSIIAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLLHKYAALLKDPTQALNEQGDSRNNSSFEDQKHLALLVMETLTVLLQGSNTNAGIFREFGGARCAHNIVRYPQCRQHALMMIQQLVLSPNGDDDMGTLLGLMHSAPPTELQLKTDILRALLSVLRESHRSRTVFRKVGGFVYVTSLLVAMERSLSAPPKNGWEKVSQGHVFELLHTVFCTLTAAMRYEPANSHFFKTEIQYEKLADAVRFLGCFSDLRKISPMNVFPSNTQPFQRLLEEDVISMDSVSPTLRHCSKLFIYLYRVATDSFDRHAYHSVSTPPVYPPKNVADLKPHVATSSLSSSDAVIIHPGAMLAMLDLLASVGSVTQPEHALDLQLAVANILQSLVHTERNQQVMCEAGLHARLLQRCSAALADEDHSLHPPLQRMFERLASQALEPMVLREFLRLASPLNCGAWDKKLLKQYRVHKPSSLSFEPEMRSSMITSMEGLGSDNVFSLHEDNHYRISKSLVKSAEGSTVPLTRVKCLVSMTTPHDIRLHGSSVTPAFVEFDTSLEGFGCLFLPSLAPHNAPTNNAVTTGLIDGAVVSGIGSGERFFPPPSGLSYSSWFCIEHFSSPPSNHPVRLLTVVRRANSSEHHYVCLAIVLSAKDRSLIVSTKEELLQNYVDDFSEESSFYEILPCCARFRCGELIVEGQWHHLVLVMSKGMLKNSTATLYIDGQLVSTVKLHYVHSTPGGSGSANPPVVSTVYAYIGTPPAQRQIASLVWRLGPTHFLEEVLPPSNVTTIYELGPNYVGSFQAVCMPCKDAKSEGVVPSPVSLVPEEKVSFGLYALSVSALTVARIRKVYNKLDSKAIAKQLGISSHENATPVKLIHNSAGHLNGPARTIGASLIGYLGVRTFVPKPVATTLQYVGGAAAILGLVAMASDVEGLYAAVKALVCVVKSNPLASKEMERIRGYQLLAMLFKKKRSLLNSHILHLTFSLVGTVDSGHETSIIPNSTAFQDLLCDFEVWLHAPYELHLSLFEHFIELLTESSEASKNAKLMREFQLIPKLLLTLRDMSLSQPTIAAISNVLSFLLQGFPNSNDLLRFGQFISSTLPTFAVCEKFVVMEINHEEKPDTGTEEEFGGLVSANLILLRNRLLDILLKLVYTSKEKTSINLQACEELVRTLGFDWIMMFMEEHLHSTTVTAAMRILVVLLSNQSILIKFKEGLSGGGWLEQTDSVLTNKIGTVLGFNVGRSAGGRSTVREINRDACHFPGFPVLQSFLPKHTNVPALYFLLMALFLQQPVSELPENLQFDLDSIWTFIFGVPASSGTVVSSIHNVCTEAAFLLLGMLRSMLNSPWQSEEEGSWLREYPVTLMQFFRYLYHNVPDLASMWMNPDFLCALAATVFPFNIRPYSEMVTDLDDEVGSPAEEFKAFAADTGMNRSQSEYCNVGVKTYLTNHPAKKFVFDFMRVLIIDNLCLTPASKQTPLIDLLLEASPERSTRTQQKEFQTYILDSVMDHLLAADVLLGEDASLPITSGGSYQVLVNNVFYFTQRVVDKLWQGMFNKESKLLIDFIIQLIAQSKRRSQGLSLDAVYHCLNRTILYQFSRAHKTVPQQVALLDSLRVLTVNRNLILGPGNHDQEFISCLAHCLINLHVGSNVDGFGLEAEARMTTWHIMIPSDIEPDGGYSQDISEGRQLLIKAVNRVWTELIHSKKQVLEELFKVTLPVNERGHVDIAIARPLIEEASLKCWQNHLAHEKKCISRGEALMPTTQSKLSRVSSGFGLSKLTGSRRNRKESGLHKHSLSTQEISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYVTEEWCQIEYELLRERGLWGPPIGSHLDKWMLEMTEGPCRMRKKMVRNDMFYNHYPYVPEMEQETNVASEIPSKQPETPDDIIPQKKPARYRRAVSYDSKEYYMRLASGNPAIVQDAIVESSEGEAAQQEPEHGEDTIAKVKGLVKPPLKRSRSAPDGGDEETQEQLQDQTAEGSSIEEEEKTDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFGKEHFYVIDGFTMTATREIRDIETLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPSLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSRLNGDNAGASVPPGSASDKIFFHHLDNLRPSLTPVKELKEPVGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKAVTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVWEMSTSKEKAKTLTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAPVSALCINELTGDIVSCAGTYIHVWSINGNPVVSVNTFTGRSQQIVCCCVSEMNEWDTQNVIVTGHSDGVVRFWRMEFLQVPETPAPEPAEVLEMQEDCPEAQIGQEAQDEDSSDSEADEQSVSQDPKDTPSQPSSTSHRPRAASCRATATWYNDSGSDDSRRWSDQLSLDEKDGFIFVNYSEGQSRPHLQTPLNHPHPNPIEARNYSRLKPGYRWERQLVFRSKLTMHTAFDRKDNAHPAEITALGVSKDHSRILVGDSRGRVFSWSVSDQPGRSAADHWVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQKCSRFQSEIKRLKISSPVRVCQNCYYNLQHERSSEDGPRNC", "length": 3484, "header": "tr|F1N6Q9-1|E1BPS3_BOVIN Computationally mapped isoform of WD repeat and FYVE domain-containing protein 3 OS=Bos taurus OX=9913 GN=WDFY3 PE=4 SV=4 CANONICAL=E1BPS3-1" }, "locus": { "chromosome": "6", "start_pos": 99723220, "end_pos": 99508635, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017949.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017949.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017949.7", "url": "https://www.ensembl.org/id/ENSBTAP00000017949.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1014, "start_aa": "Thr", "end_pos": 1014, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1014", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1047, "start_aa": "Thr", "end_pos": 1047, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1047", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", 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"MKREWAPSGRQSVVSSAAARTSGLLIQPLESRVSVPTAITATPSAEMPQHSTGDKPLVSKPQLVFPGPASGTDSECDRTPPSRRVSLSAPLSQPLCQPEKCGPRAAQEVCYVAAGQPGEACGWRAFAPMCLQAFNTPQGFLLFLCVASFLQGMTVNGFINTVITSIERRYDLHSYQSGLIASSYDVAACLCLTFVSYFGGQGHKPRWLGWGVLVMGAGSLVFALPHFTAGRYEVQMDEVVGTCWANHSSTCKDGASGLSSYRLVFMLGQFLHGMGATPLYTLGVTYLDENVKSSYSPVYIATFYTAAILGPAAGYLVGGALLNIYTDISQQTQLTTESPLWVGAWWVGFLGAGAAAFLVAIPILGYPRQLPGSQRYVVMRASETYQLKDSSHKVTSNPDFGKTISDLPLSIWLLLKNPTFILLCLAGATEATLIASMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFFVNKFKLRGSGIIKFCLLCTLVSLLASLIFLMHCPGVPMAGVTAGYNGSLLPEGHVELMAACNLHCSCQPEHYSPVCGSDGLMYYSPCYAGCLEMAVSSPGGQKVYRDCSCVPQNFSSGFGHATAGKCTSTCQRKPLLLVFIFVVIVFTFLSSIPALTATLRCVCDQQRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGQQGSCFVYQNSAMSWYLLIAGLGYKVLGSIFFAIACFLYKSPPGSSDGLEASLPSQSSASDNPSDLQEAPSALQIQSDI", "length": 764, "header": "tr|E1BPV8-1|E1BPV8_BOVIN Isoform 1 of Solute carrier organic anion transporter family member OS=Bos taurus OX=9913 GN=SLCO4A1 PE=3 SV=2 CANONICAL=E1BPV8-1" }, "isoforms": [ { "isoform_ac": "E1BPV8-1", "url": "https://www.uniprot.org/uniprotkb/E1BPV8/entry", "sequence": { "sequence": "MKREWAPSGRQSVVSSAAARTSGLLIQPLESRVSVPTAITATPSAEMPQHSTGDKPLVSKPQLVFPGPASGTDSECDRTPPSRRVSLSAPLSQPLCQPEKCGPRAAQEVCYVAAGQPGEACGWRAFAPMCLQAFNTPQGFLLFLCVASFLQGMTVNGFINTVITSIERRYDLHSYQSGLIASSYDVAACLCLTFVSYFGGQGHKPRWLGWGVLVMGAGSLVFALPHFTAGRYEVQMDEVVGTCWANHSSTCKDGASGLSSYRLVFMLGQFLHGMGATPLYTLGVTYLDENVKSSYSPVYIATFYTAAILGPAAGYLVGGALLNIYTDISQQTQLTTESPLWVGAWWVGFLGAGAAAFLVAIPILGYPRQLPGSQRYVVMRASETYQLKDSSHKVTSNPDFGKTISDLPLSIWLLLKNPTFILLCLAGATEATLIASMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFFVNKFKLRGSGIIKFCLLCTLVSLLASLIFLMHCPGVPMAGVTAGYNGSLLPEGHVELMAACNLHCSCQPEHYSPVCGSDGLMYYSPCYAGCLEMAVSSPGGQKVYRDCSCVPQNFSSGFGHATAGKCTSTCQRKPLLLVFIFVVIVFTFLSSIPALTATLRCVCDQQRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGQQGSCFVYQNSAMSWYLLIAGLGYKVLGSIFFAIACFLYKSPPGSSDGLEASLPSQSSASDNPSDLQEAPSALQIQSDI", "length": 764, "header": "tr|E1BPV8-1|E1BPV8_BOVIN Isoform 1 of Solute carrier organic anion transporter family member OS=Bos taurus OX=9913 GN=SLCO4A1 PE=3 SV=2 CANONICAL=E1BPV8-1" }, "locus": { "chromosome": "13", "start_pos": 54695748, "end_pos": 54672728, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021795.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021795.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021795.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021795.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 42, "start_aa": "Thr", "end_pos": 42, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr42", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-879518", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-879518", "resource": "Reactome", "description": "Organic anion transport by SLCO transporters" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZS46-1", "protein_name": "Solute carrier organic anion transporter family member", "gene_name": "SLCO4A1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNEAGVGAERQSERGAQRGCRALGTIDPTAGAPPVLLHCRRCRASSKMPQHSVGDKPFVSMPQPVFPGPPLAANGSCDHTPPGRRASLCSPLSPSALRAAAHGPLDSSSQPLCQPEKHGPRAAAREVHYVAAGPGEACGWRAFAPACLQVFNTPCGFLLFLCAASFLQGMTVNGFINSVITSIERRFDLHSYQSGLTASSYDVAACLCLTFVSYFGGHGHKPRWLGWGVLVMGAGSLVFALPHFTTGPYEVQGDQVVGTCRANQSAPCGGRASSLSSYRLVFMLGQFLHGVGATPLYTLGVTYLDENVKSSSSPVYLATFYTAAILGPAAGYLVGGALLNIYTEIGTRTELTTESPHWVGAWWVGFLGAGAAAFLIAVPILGYPRQLPGSQRYVVMRASETHQLKDSGHKAASNPDFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLIAGMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFFVNKLKLRGSGTIKFCLLCTLASGLTTLAFLTHCPNVPMAGVTVSYNGSLLPEGHLELTAACNAHCGCWAGHYTPVCGSDGLMYHSPCHAGCTEAATPGPGGQMVYRDCSCVPQNLSSGFGHATAGKCTSTCQRKPLLLVFIFVVIIFTFLSSIPALTATLRCVCDRQRSFALGIQWIVVRTLGGIPGPIAFGWVIDKSCLLWQDQCGQQGSCFVYQNSAMSRYMLITGLLYKTSSDRATREKAICVALNKSDRSWASSSSPLPASSTSPCRRLQMAWKPLCPASPRPPTIPQTFREPPRPSSSRAMSDRSPARQGQGPPGSASPELCLISRRKG", "length": 829 }, "evidence": [ { "id": "E1BPV8", "url": "https://omabrowser.org/oma/group/E1BPV8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7G7E3-1", "protein_name": "Solute carrier organic anion transporter family member", "gene_name": "Slco4a1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNEARVGSARRPERRAQRGSRVRGKAASTESHLLRCKALCTRLEMPQHVMGDKPFLSLPKHLLTNASSATDSGCDTPPSSRASPASLRSAHSPLGSSSQPLFEPQVGKRRSQTAREVQYMSAGPKNTLCGWRAFTPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFINTVITSIEQRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGVLVLGIGSLVFALPHFTAGRYEVEMDEGVGVGTGACLANGSHVECMDSGLSSYRLVFMLGQLLHGVGATPLYTLGVTYLDENVKSNYSPIYIAIFYTAAILGPAAGYLIGGAMLNIYTEVSQRTDLTTDSPLWVGAWWIGFVGAGITAFLIAIPILGYPRQLPGSQRYIVMRAAEKQQLKDHSHRTVSNPAFGKTVRDLPLSIWLLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNRFKLRGSGIIRFCLFCTLTSLLAFFVFLTHCPNMPMAGVTTSYVGSPLPEGHLDLKAACNAIYCCQEEHYSPLCGSDGTMYYSPCYAGCPAGAETGPSGQKIYRGCSCILQNVSSGLGNATAGKCTSTCQRKPLLLALVFVVIIFTFLSSIPALTATLRCVCDQQRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYRNEAMSRYMLIAGLTFKVLGFLFFVTAYFLYKSPSVSSDGLETSLPSQSSASDNPTEQLQSNV", "length": 767 }, "evidence": [ { "id": "E1BPV8", "url": "https://omabrowser.org/oma/group/E1BPV8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8K078-1", "protein_name": "Solute carrier organic anion transporter family member 4A1", "gene_name": "Slco4a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPQHAMGDTHFLSLPKHLFTSTSSATDSGCDTPPSSRASPASLRSAHGTLGSSSQPLFEPQAEKRSSQTAREVQYVSSGPQNSLCGWQAFTPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGVLVLGIGSLVFALPHFTAGRYEVEMDEGLGTGTCLTNQSHVECKDSASGLSNYRLIFMLGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDHSRGAVSNPAFGKTVRDLPLSIWLLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFLMHCPNVHMAGVTTGYVGSLLPKGQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCPADAETDLGGQKVYRGCSCILEKASSGWGNATAGKCASTCQSKPFLLVLVFVVIIFTFLSSIPALTATLRCVSDRQRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYENEAMSRYMLIAGLTFKVLGFLFFVAAYFLYKSPSVSSDGLEASLPSQSSASDSPTEQLQSNV", "length": 723 }, "evidence": [ { "id": "E1BPV8", "url": "https://omabrowser.org/oma/group/E1BPV8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96BD0-1", "protein_name": "Solute carrier organic anion transporter family member 4A1", "gene_name": "SLCO4A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLHQLGDKPLTFPSPNSAMENGLDHTPPSRRASPGTPLSPGSLRSAAHSPLDTSKQPLCQLWAEKHGARGTHEVRYVSAGQSVACGWWAFAPPCLQVLNTPKGILFFLCAAAFLQGMTVNGFINTVITSLERRYDLHSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLLMGTGSLVFALPHFTAGRYEVELDAGVRTCPANPGAVCADSTSGLSRYQLVFMLGQFLHGVGATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAILGPAAGYLIGGALLNIYTEMGRRTELTTESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQLPGSQRYAVMRAAEMHQLKDSSRGEASNPDFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFFVNKLRLRGSAVIKFCLFCTVVSLLGILVFSLHCPSVPMAGVTASYGGSLLPEGHLNLTAPCNAACSCQPEHYSPVCGSDGLMYFSLCHAGCPAATETNVDGQKVYRDCSCIPQNLSSGFGHATAGKCTSTCQRKPLLLVFIFVVIFFTFLSSIPALTATLRCVRDPQRSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQNSAMSRYILIMGLLYKVLGVLFFAIACFLYKPLSESSDGLETCLPSQSSAPDSATDSQLQSSV", "length": 722 }, "evidence": [ { "id": "E1BPV8", "url": "https://omabrowser.org/oma/group/E1BPV8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99N01-1", "protein_name": "Solute carrier organic anion transporter family member 4A1", "gene_name": "Slco4a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPQHAMGDKHFLSLPKHLFTSTSSTTDSGCDTPPSSRASPASLRSAHGALGSSSQPLFEPQVEKRSSQAACEVQYLSSGPQSTLCGWQSFTPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGIGSLVFALPHFTAGRYEVEIDDEGLGTETGTCLTNQSQVECKDRASGLSSYRLIFMLGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDHSRDNPAFGKTVRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFLMHCPNVHMAGVTTGYVGSLLPKGQLDLKAACNALYCCQPRHYSPLCGSDGTMYYSPCYAGCPEGAVTGPGGQKVYRGCSCILEKASSGWGNATAGKCASTCQSKPLLLVLVFVVIIFTFLSSIPALTATLRCVCDRQRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYKNEAMSRYLLIAGLTFKVLGFLFFVAAYFLYKSPSVSSDGLEASLPSQSSASDSPTEQLQSNV", "length": 723 }, "evidence": [ { "id": "E1BPV8", "url": "https://omabrowser.org/oma/group/E1BPV8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "monoatomic ion transport", "id": "GO:0006811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006811", "evidence": [ { "database": "UniProtKB", "id": "E1BPV8", "url": "https://www.uniprot.org/uniprotkb/E1BPV8" } ], "pmid": "" }, { "name": "sodium-independent organic anion transport", "id": "GO:0043252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043252", "evidence": [ { "database": "UniProtKB", "id": "E1BPV8", "url": "https://www.uniprot.org/uniprotkb/E1BPV8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "E1BPV8", "url": "https://www.uniprot.org/uniprotkb/E1BPV8" } ], "pmid": "" }, { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "E1BPV8", "url": "https://www.uniprot.org/uniprotkb/E1BPV8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "thyroid hormone transmembrane transporter activity", "id": "GO:0015349", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015349", "evidence": [ { "database": "UniProtKB", "id": "E1BPV8", "url": "https://www.uniprot.org/uniprotkb/E1BPV8" } ], "pmid": "" }, { "name": "prostaglandin transmembrane transporter activity", "id": "GO:0015132", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015132", "evidence": [ { "database": "UniProtKB", "id": "E1BPV8", "url": "https://www.uniprot.org/uniprotkb/E1BPV8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 524, "end_pos": 526, "annotation": "n_glycosylation_sequon" }, { "start_pos": 592, "end_pos": 594, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPV8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 764, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPV8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPV8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "E1BPV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPV8" }, { "id": "PS51465", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51465" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kazal-like", "eco_id": "ECO_0000259", "start_pos": 533, "end_pos": 590, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "E1BPV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPV8" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 140, "end_pos": 725, "start_aa": "Phe", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 42 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 246, "end_pos": 248 }, { "start_pos": 524, "end_pos": 526 }, { "start_pos": 592, "end_pos": 594 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BPV9-1", "uniprot_ac": "E1BPV9", "uniprot_id": "E1BPV9_BOVIN", "mass": { "chemical_mass": 403728.0, "monoisotopic_mass": 403728.0 }, "refseq": { "ac": "XP_010812999", "name": "zinc finger homeobox protein 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812999" }, "gene_names": [ { "name": "ZFHX3", "type": "recommended", "evidence": [ { "id": "E1BPV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPV9" } ] }, { "name": "ZFHX3", "type": "synonym", "evidence": [ { "id": "XP_010812999", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812999" } ] } ], "protein_names": [ { "name": "Zinc finger homeobox protein 3", "type": "recommended", "evidence": [ { "id": "E1BPV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPV9/entry#names_and_taxonomy" } ] }, { "name": "AT motif-binding factor 1", "type": "synonym", "evidence": [ { "id": "E1BPV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPV9/entry#names_and_taxonomy" } ] }, { "name": "AT-binding transcription factor 1", "type": "synonym", "evidence": [ { "id": "E1BPV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPV9/entry#names_and_taxonomy" } ] }, { "name": "Alpha-fetoprotein enhancer-binding protein", "type": "synonym", "evidence": [ { "id": "E1BPV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPV9/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger homeodomain protein 3", "type": "synonym", "evidence": [ { "id": "E1BPV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPV9/entry#names_and_taxonomy" } ] }, { "name": "zinc finger homeobox protein 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010812999", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812999" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BPV9", "url": "https://www.uniprot.org/uniprotkb/E1BPV9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZFHX3", "url": "https://www.uniprot.org/uniprotkb/E1BPV9", "locus": { "chromosome": "18", "start_pos": 38362980, "end_pos": 38109982, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014636", "url": "https://www.ensembl.org/id/ENSBTAG00000014636" } ] } } ], "crossref": [ { "id": "ENSBTAG00000014636", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014636", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510844", "url": "https://www.ncbi.nlm.nih.gov/gene/510844", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003604", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003604", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051968", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051968", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510844", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510844", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NPGPKES", "url": "https://omabrowser.org/oma/group/NPGPKES/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BPV9", "url": "https://www.orthodb.org/?gene=E1BPV9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45891", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45891", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45891:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45891:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24056", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24056", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8941855", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8941855", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010812999", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812999", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BPV9", "url": "https://www.uniprot.org/uniprotkb/E1BPV9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BPV9-1", "url": "https://www.uniprot.org/uniprotkb/E1BPV9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGCDSPVVSGKDNGCGIPQHQQWTELNSTHLPDKPSSMEQPTSESHGPLDGLRAPFNERLAESTAPAGPAAEPAAATAGKEVSCNECSASFASLQTYMEHHCPGARPPPPPPPPPPREESGSDSSEEGDEESDVENLAGEIVFQPDGSAYIVESLSQLTQGGGVGGGGPLPSLFLNSLPSAAAASGGKQGDPSCAAPVYPQIINTFHIASSFGKWFEGPDQAFPNTSALAGLSPVLHSFRVFDVRHKSSKDYLNSDGSAKSSCVSKDAPNNVDLSKFDGFVLYGKRKPILMCFLCKLSFGYVRSFVTHAVHDHRMTLSEEERKILSNKNISAIIQGIGKDKEPLVSFLEPKNKNFQLPLVSTANLIGPGHSFYGKFSGIRMEGEEALPAGPTAGPEQPQAGLLTPSTLLNLGGLTSSVLKTPITSVPLGPLASSPTKSSEGKDSGAAEGEKQEVGDPDCFSEKAEPAEEEAEEEEEEEEAEEEEEEEEDEEEEEEEEGCKGLFPSELDDELEDRPPEESGAAAGSSSKKDLALSNQSISNSPLMPNVLQTLSRGAASTSSNSASSFVVFDGANRRNRLSFNSEGVRANVAEGGRRLDFADESANKDNATAPEPNESTEGDEGGFVPHHQHAGSLCELGVGECPSGSGVECPKCDTVLGSSRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKSGQPHPRLARGESYTCGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNMQNLQNGGGEQVFSHTAGAAAAAAAAAAAAANMGSSCGAPSPTKPKTKPTWRCEVCDYETNVARNLRIHMTSEKHMHNMMLLQQNMTQMQHSRHLGLGGLPSPAEAELYQYYLAQNVNLPNLKVDSTAPDAPFVMSGFQLDPAGPVAAMTPALVGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDTLDLLGLHMNVERSLPEEEWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESGVEGESCYYHCVLCSYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSEAAADPEELAKDQESGGEKDQSKWTASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTSEETKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPLCQDMLNNKIHLQLHLTHLHSVAPDCVEKLIMTVTTPEMVMPSSMFLPAAVPDRDGSSSVEEAGKQPETSEDLGKNILPSVSTEHSGDLKPSPVDSGSVREDSGFLCWKKGCNQVFKTSATLQTHFNEVHAKRPQLPVSDRHVYKYRCNQCSLAFKTVEKLQLHSQYHVIRAATMCCLCQRSFRTFQALKKHLETSHLELSEADIQQLYGGLLANGDLLAMGDPTLAEDHTIIVEEDKEEESDLEDKQSPTGSDSGSVQEDSGSEPKRALPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLKRALQESATGQPEPTSSPDNKPFKCNTCNVAYSQSSTLEIHMRSVLHQTKARAAKLEAASSSSNGTGGSSTAPLSSSTPSPVSTSGSNTFTTTNPSSAGIAASSSLLSQVPAESVGMPPLGNPISANIVSPAEPKEANRKKLADMIASRQQQQQQQQQQQAQTLAQAQAQVQAHLQQELQQQAALIQSQLFNPTLLPHFPMTTETLLQLQQQQHLLFPFYIPSAEFQLNPEVSLPVTSGALTLTGTGPGLLEDLKAQVQIPQQGHQQMLQQQQQSQLPLPQSHPALLQPSQHAEKKNKLVIKEKEKESQRERDGAEGGEINSGPKESLPDALKAKEKKELAPGVSSEPSMLPPRIASDARGNATKALLENFGFELVIQYNENKQKVQKKNGKMEQGENPEKLECDSCGKLFSNILILKSHQEHVHQNYFPFKQLERFAKQYREHYDKLYPLRPQTPEPPPPPPPPPPPPLPAAPPQPASTPAIPTSAPPITSPTIAPAQPSVPLTQLSMPMELPIFSPLMMQTMPLQTLPAQLPPQLGPVEPLPADLAQLYQHQLNPSLLQQQNKRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITSLEELKIDSRPPSPEPQKQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARKNYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLVFQRIFDLIKHQKKLCYKDEDEEGQDDSQNEDSMDAMEILTPTSSSCSTPMPSQAYSTPAPAASTASSAFLQLPSEADELATFSAKPEVSDEKPKQAEPPSAQPNQTQDKQGQPKAELQQQDQPEQKMSTAQQKLPQLTSPAPVPTQPPPQAPPPQCPLPQSSPSPSQLSHLPLKPLHTSTPQPLANLPPQLIPYQCDQCKLAFPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPSNPLLASQLLSGAIPQIPASSATSPSTPTSTMNTLKRKLEEKASASPGENDSGTGGEEPQRDKRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSFSHLPPSSSDGQGVPLSPVSKTMELSPRTLLSPSSIKVEGMEDFESPSMSSVNLNFDQTKLDNDDCSSVNTAITDTTTGDEGNADNDSATGIATETKSSSAPSEGLTKAAMMAMSEYEDRLSSGLVSPAPSFYSKEYDNEGTVDYSETSSLADPCSPSPGVSGSAGKSGDSGDRPGQKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKSKLSMAKHFGINQTSYEGPKTECTLCGIKYSARLSVRDHIFSQQHISKVKDTIGSQLDKEKEYFDPATVRQLMAQQELDRIKKANEVLGLAAQQQGMFDNAPLQALNLPTAYPALQGIPPVLLPGLNSPSLPGFTPSNTALTSPKPNLMGLPSTTVPSPGLPTSGLPNKPSSASLSSPTPAQATMAMAPQPAPQPQQQQPQVQPPPPAAQPPPAPQLPPQQQPQQRKDKDGEKVKEKEKAHKGKGEPLPVPKKEKGEAPTAAAATLSAPLPAMEYAVDPAQLQALQAALTSDPTALLTSQFLPYFVPGFSPYYAPQIPGALQSGYLQPMYGMEGLFPYSPALSQALMGLSPGSLLQQYQQYQQSLQEALQQQQQRQLQQQQQKVQQQQPKASQTPVPPGAASPDKDPAKESPKPEEQKNAPREVSPLLPKPPEEPEAESKSADSLYDPFIVPKVQYKLVCRKCQAGFGDEEAARSHLKSLCFFGQSVVNLQEMVLHVPTGGGGGGSGGGGGGGSYHCLACESALCGEEALSQHLESALHKHRTITRAARNAKEHPSLLPHSACFPDPSTASTSQSAAHSNDSPPPPSAAAPSSSSASPHASRKSWPQVVSRASAAKPPSFPPLSSSSTVTSSSCSTSGVQPSMPTDDYSEESDTDLSQKSDGPASPVEGPKDPSCPKDSGLTSVGTDTFRL", "length": 3704, "header": "tr|E1BPV9-1|E1BPV9_BOVIN Isoform 1 of Zinc finger homeobox protein 3 OS=Bos taurus OX=9913 GN=ZFHX3 PE=4 SV=3 CANONICAL=E1BPV9-1" }, "isoforms": [ { "isoform_ac": "E1BPV9-1", "url": "https://www.uniprot.org/uniprotkb/E1BPV9/entry", "sequence": { "sequence": "MEGCDSPVVSGKDNGCGIPQHQQWTELNSTHLPDKPSSMEQPTSESHGPLDGLRAPFNERLAESTAPAGPAAEPAAATAGKEVSCNECSASFASLQTYMEHHCPGARPPPPPPPPPPREESGSDSSEEGDEESDVENLAGEIVFQPDGSAYIVESLSQLTQGGGVGGGGPLPSLFLNSLPSAAAASGGKQGDPSCAAPVYPQIINTFHIASSFGKWFEGPDQAFPNTSALAGLSPVLHSFRVFDVRHKSSKDYLNSDGSAKSSCVSKDAPNNVDLSKFDGFVLYGKRKPILMCFLCKLSFGYVRSFVTHAVHDHRMTLSEEERKILSNKNISAIIQGIGKDKEPLVSFLEPKNKNFQLPLVSTANLIGPGHSFYGKFSGIRMEGEEALPAGPTAGPEQPQAGLLTPSTLLNLGGLTSSVLKTPITSVPLGPLASSPTKSSEGKDSGAAEGEKQEVGDPDCFSEKAEPAEEEAEEEEEEEEAEEEEEEEEDEEEEEEEEGCKGLFPSELDDELEDRPPEESGAAAGSSSKKDLALSNQSISNSPLMPNVLQTLSRGAASTSSNSASSFVVFDGANRRNRLSFNSEGVRANVAEGGRRLDFADESANKDNATAPEPNESTEGDEGGFVPHHQHAGSLCELGVGECPSGSGVECPKCDTVLGSSRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKSGQPHPRLARGESYTCGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNMQNLQNGGGEQVFSHTAGAAAAAAAAAAAAANMGSSCGAPSPTKPKTKPTWRCEVCDYETNVARNLRIHMTSEKHMHNMMLLQQNMTQMQHSRHLGLGGLPSPAEAELYQYYLAQNVNLPNLKVDSTAPDAPFVMSGFQLDPAGPVAAMTPALVGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDTLDLLGLHMNVERSLPEEEWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESGVEGESCYYHCVLCSYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSEAAADPEELAKDQESGGEKDQSKWTASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTSEETKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPLCQDMLNNKIHLQLHLTHLHSVAPDCVEKLIMTVTTPEMVMPSSMFLPAAVPDRDGSSSVEEAGKQPETSEDLGKNILPSVSTEHSGDLKPSPVDSGSVREDSGFLCWKKGCNQVFKTSATLQTHFNEVHAKRPQLPVSDRHVYKYRCNQCSLAFKTVEKLQLHSQYHVIRAATMCCLCQRSFRTFQALKKHLETSHLELSEADIQQLYGGLLANGDLLAMGDPTLAEDHTIIVEEDKEEESDLEDKQSPTGSDSGSVQEDSGSEPKRALPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLKRALQESATGQPEPTSSPDNKPFKCNTCNVAYSQSSTLEIHMRSVLHQTKARAAKLEAASSSSNGTGGSSTAPLSSSTPSPVSTSGSNTFTTTNPSSAGIAASSSLLSQVPAESVGMPPLGNPISANIVSPAEPKEANRKKLADMIASRQQQQQQQQQQQAQTLAQAQAQVQAHLQQELQQQAALIQSQLFNPTLLPHFPMTTETLLQLQQQQHLLFPFYIPSAEFQLNPEVSLPVTSGALTLTGTGPGLLEDLKAQVQIPQQGHQQMLQQQQQSQLPLPQSHPALLQPSQHAEKKNKLVIKEKEKESQRERDGAEGGEINSGPKESLPDALKAKEKKELAPGVSSEPSMLPPRIASDARGNATKALLENFGFELVIQYNENKQKVQKKNGKMEQGENPEKLECDSCGKLFSNILILKSHQEHVHQNYFPFKQLERFAKQYREHYDKLYPLRPQTPEPPPPPPPPPPPPLPAAPPQPASTPAIPTSAPPITSPTIAPAQPSVPLTQLSMPMELPIFSPLMMQTMPLQTLPAQLPPQLGPVEPLPADLAQLYQHQLNPSLLQQQNKRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITSLEELKIDSRPPSPEPQKQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARKNYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLVFQRIFDLIKHQKKLCYKDEDEEGQDDSQNEDSMDAMEILTPTSSSCSTPMPSQAYSTPAPAASTASSAFLQLPSEADELATFSAKPEVSDEKPKQAEPPSAQPNQTQDKQGQPKAELQQQDQPEQKMSTAQQKLPQLTSPAPVPTQPPPQAPPPQCPLPQSSPSPSQLSHLPLKPLHTSTPQPLANLPPQLIPYQCDQCKLAFPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPSNPLLASQLLSGAIPQIPASSATSPSTPTSTMNTLKRKLEEKASASPGENDSGTGGEEPQRDKRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSFSHLPPSSSDGQGVPLSPVSKTMELSPRTLLSPSSIKVEGMEDFESPSMSSVNLNFDQTKLDNDDCSSVNTAITDTTTGDEGNADNDSATGIATETKSSSAPSEGLTKAAMMAMSEYEDRLSSGLVSPAPSFYSKEYDNEGTVDYSETSSLADPCSPSPGVSGSAGKSGDSGDRPGQKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKSKLSMAKHFGINQTSYEGPKTECTLCGIKYSARLSVRDHIFSQQHISKVKDTIGSQLDKEKEYFDPATVRQLMAQQELDRIKKANEVLGLAAQQQGMFDNAPLQALNLPTAYPALQGIPPVLLPGLNSPSLPGFTPSNTALTSPKPNLMGLPSTTVPSPGLPTSGLPNKPSSASLSSPTPAQATMAMAPQPAPQPQQQQPQVQPPPPAAQPPPAPQLPPQQQPQQRKDKDGEKVKEKEKAHKGKGEPLPVPKKEKGEAPTAAAATLSAPLPAMEYAVDPAQLQALQAALTSDPTALLTSQFLPYFVPGFSPYYAPQIPGALQSGYLQPMYGMEGLFPYSPALSQALMGLSPGSLLQQYQQYQQSLQEALQQQQQRQLQQQQQKVQQQQPKASQTPVPPGAASPDKDPAKESPKPEEQKNAPREVSPLLPKPPEEPEAESKSADSLYDPFIVPKVQYKLVCRKCQAGFGDEEAARSHLKSLCFFGQSVVNLQEMVLHVPTGGGGGGSGGGGGGGSYHCLACESALCGEEALSQHLESALHKHRTITRAARNAKEHPSLLPHSACFPDPSTASTSQSAAHSNDSPPPPSAAAPSSSSASPHASRKSWPQVVSRASAAKPPSFPPLSSSSTVTSSSCSTSGVQPSMPTDDYSEESDTDLSQKSDGPASPVEGPKDPSCPKDSGLTSVGTDTFRL", "length": 3704, "header": "tr|E1BPV9-1|E1BPV9_BOVIN Isoform 1 of Zinc finger homeobox protein 3 OS=Bos taurus OX=9913 GN=ZFHX3 PE=4 SV=3 CANONICAL=E1BPV9-1" }, "locus": { "chromosome": "18", "start_pos": 38361976, "end_pos": 38198155, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000019489.8", "url": "https://www.ensembl.org/id/ENSBTAT00000019489.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000019489.6", "url": "https://www.ensembl.org/id/ENSBTAP00000019489.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2071, "start_aa": "Thr", "end_pos": 2071, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2071", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3192, "start_aa": "Thr", "end_pos": 3192, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3192", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3273, "start_aa": "Thr", "end_pos": 3273, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3273", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 393, "start_aa": "Thr", "end_pos": 393, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr393", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510844", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510844", "resource": "KEGG Pathway" }, { "id": "R-BTA-8941855", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8941855", "resource": "Reactome", "description": "RUNX3 regulates CDKN1A transcription" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M9QI68-1", "protein_name": "Zinc finger homeobox protein 3", "gene_name": "zfhx3b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MESCESPVVSGTDDGLGSSATSQQHHPQPWNDHPNAQVPPCNQSPSLEPLSLSAPHSAQIQNPSTHCEALREQQKQTLSQAPSDISTSRQLHLKREGLEEEEQEGVSCGEEDEDLEDLDEMEIDSCFPSLQPFPGVPMVPSGGGMPMLMRQQPSHRRGAMESGSEEGEEEEEEESSDVENLAGEIVYQPDGSAYIVESLSQLIQSDGSMEPGLLSSNSLTSGGKPGEPVGTSSVYPQIINTFHIASSFGKWFGSSDQGFPNTSTLTGLSPVLHSFRVFDVRHKSNKDYLNSDGSAKKSCVSKDVPNNVDFSKFDGLALYGKGKPILMCFLCKLSFGYARSFVTHAVHDHRMTLCEDERRLLGHKHASAIIQGIGKDKEPLISFLEPKNKNSPSPPTLVPMNSGQSFYGTFSGVHLEGGSSSEGGESLLNKDSDSGLQQQALLTLGGLGSPKASSLTSTPGPAKDSSTLSKPQGRRTDGSVGKEGTHRGEDGNAEICERKTLLPGEEMPSDEEDELLLEEEDEEVEDEGTAVACSGSSSSSGRFVGEPAVSNQSISKSPLLMPSSALQPSACLSAASPALSSKFSASMSSSIRGAEDGMAADGGGRTSELPLSFNCQGSTVPMAMAAVAGRGGEEDGAACSAASTSSPLASNAAAEESANRDSATAPEPNECPAEGDEDNGALLHHHLHHHHHHLHPSPNAHTHLHHTAACDLSGISECTQNHGAGGSGGSGVECPKCDTVLGSSRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPDSGGSCVYCSSGQSHPRLARGESYTCGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNMQTLQNGGTIPTGEQVFGHAPGGVVPVSSASQPGSHHPSHHHHPAQSSTHMTGPCGAPSPTKPKSKPTWRCEVCDYETNVARNLRIHMTSEKHMHNMMLLQQNMSQMQHGRLGLGAMPSPSEAELYQYYLTQNMSLPPGLKMDPSGADAQFLLGGFHLDPNMAALAPALVGGDIAMDVRLGGGQLVSEELMTLGESLSQTSDPSLKLFQCAVCNRFTTDNLDVLGLHMSAERSLPEEEWRAVVGDSHQCKLCHYTTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKGNEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRMHTVNSRHEASLKLYKHLQQHENAVEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEEEELSAIFTIRKCPSADTGELSEDVEAASETTTDQEDQTKDKESGGERELTKGTASNQPERDQTDSPVPSKRPSSRSETAESPLSSKRPRTTEKSSGEQMYQCPYCKFSNTDLNRLRMHVMTQHSVQPMFRCPLCQDMLNNKVHLQFHLTHLHSVAPDCVDKLIATVAASEVLPASMFIPVPGPEKDTQTAPQSMANSNSDDTKKLTEVADAEPEKGVCLTSDTAEARKSPLEEQQPARDDSTGFLCWKKGCNKVFKSSSALQMHFNEVHNKRPQLPVSDRHVYKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLCQRSFRTLQALKKHLETSHLELSEADIQQLYGGLLMNGDLMIMGDPSLGEDQGGLLDDEKEGDESDPEEKQSPTGSDSGSLLEDSGSEPKRALPFRKGPNFTMEKFLDPSRPFKCTVCKESFTQKNILLVHYNSVSHLHKVKRALQESTTGQPEPTSSPDNKPFKCSTCNVAYSQSSTLEIHMRSVLHQTKARAAKLEAAGGSSTAVSSSGPSGSTSNSTSTPSPIPATNSTTSSSNSSSSPAGAQTAQSIIGGNHLSSHSHSVENLGNSASHTSSSENHEVKKKKFSDMLSSRSHQQQLQQQQQQLAQAQAQAQAQLQQELQQAALLQSQLFNPLLQHFPMTTDALLPLQQQQLLFPFYIPGAEFQLNPEMNLNSSSLNLSGSTASLLEEQKNSVQQAQQSCLQQQLMHHHLQQQHQAHSHSQGSSQMALLQQSALSHPVDKKTKPSPHTEKERDLPKDKEISDKSEDHVPKDLSDKSKEKIDATQALVNVNHDSGFPPPRIASDARGNATKALLENFGFELVIQYNENKQKAQRKSTGSLPGCTGTAGFTRVVDPIEGLEKLECESCGKLFSNILILKSHQEHIHQAFFPFRFLERFAKEYREQYDKLYPLRPQTPEAAPAPPPPPPPPPPPPPQRAPTPNIPVSAPTLTPPTAPTPQPPVPLSQIPMAMDLPLFSPLMMQPMSLQSLPSQIPAQLPTVEPSLATDLAQLYQQQLTPAMLQQQNKRPRTRITDDQLRVLRQYFDINNSPNEEQIKEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFNNPPITTLEETKIDSKPPSPEPLKQEAYGNKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARKNYENQGDGVKEGDRRELSNDRYIRTTNLNYQCKKCSLVFQRIFDLIKHQKKLCYKDEEDDGQYDSLNEDSLDLSHEYYTPSGSSGQTPMPSSSSLCPLPPSSAFSHIASSEKEEPTPANTSNSFDEKSRHSAETTLGQREQTSLKQETSHPSETPQQRPQREEKMHAVPKNSKLSSPSLSQQQQHSGPSVSHTSQTSQSSHMALNPHLASASQQQLAQQMIPYQCEQCKLAFPSFEHWQEHQQLHFLSVQNQFIHPQFLDRPMDMSFMLFDPSNPLLASQLLAGAIPQMSSNSATSPSTPTSTMNSLKRKLEEKAGTSPGESDSMNSGEEPQRDKRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEAKRAGYNLALSGLLPEQEAMQLKMDPLDISSYAHLAQSNNDAQCSSLSPISKVMDLSPRALLSPTSIKVEGVEEFESPTISSVNTNFDHNKLDNDDCSSVNTAITDTTTGDEANVDNDSADAKHSQNSGDFLSKSGGTAPSIENDEQMSSGLVSPATSYYTKDFENENMIDYSETSSLADPCSPSPGASGSRSIDSGDRPGQKRFRTQMTNLQLKVLKSCFSDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKAKLSMAKHFGINQTSYEGPKTECSLCGVKYSARLSVRDHIFSQQHISKVKDTIGSQLDKEKEYFDPATVRQLMAQQEMDRIKKANEVLGLAQQQAMQQQGMFDTPALQALNLQSGYPNLQGIPPVLLPGVGGPSIPGFNSSNSALTPPKPPNLLNMPGASVPSPSLPTSGLPNKTPSSSSLASPSPAQASTSVAHSSPTPTSTTNSLMTQPGARPEAPKDRDPERAREKEKPKEKAEKSSTPSSAGGTPAPSTSAASAKKEKTDTAVPATSMPTPGMEYVVDTAQLQALQAALASDPTALLTSQFLPYFMPGFSPYYAPQIPGALQGGYLQPMYGMESLFPYNPALSQALMGLSPGSLLQHYQQYQQSLQEALQQQQRQLQQIQQPKASQTSQNSVDRKDSAKDSVKTEQKSTPSAETSSTHNNVAAEQHEVDGKGADPHLDQYIVPKVQYRLACRKCQAVFSKEEAAISHLKSICFFGQSVANLQEMLLRVPNSGNAAEGGLYDCLACDTTLEGDKALSQHLDSALHKHRTIKRSRNAKEHATNLLPHSSACFPSPNTASTSQSATHSNNTTSPPPTTSATTPSSSTTASSCTSTSFTASPLNTTATGKSWSQAPFSRALAGQPNPPSSALSSFPPVSSPSTVTSSSLSTSGVQTSIPTDVFTDESDSDSSQKSADRLGRPAEEPQQPGCLKDSSSCSSNLTSVGSDSIRL", "length": 3838 }, "evidence": [ { "id": "E1BPV9", "url": "https://omabrowser.org/oma/group/E1BPV9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q15911-1", "protein_name": "Zinc finger homeobox protein 3", "gene_name": "ZFHX3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGCDSPVVSGKDNGCGIPQHQQWTELNSTHLPDKPSSMEQSTGESHGPLDSLRAPFNERLAESTASAGPPSEPASKEVTCNECSASFASLQTYMEHHCPSARPPPPLREESASDTGEEGDEESDVENLAGEIVYQPDGSAYIVESLSQLTQGGGACGSGSGSGPLPSLFLNSLPGAGGKQGDPSCAAPVYPQIINTFHIASSFGKWFEGPDQAFPNTSALAGLSPVLHSFRVFDVRHKSNKDYLNSDGSAKSSCVSKDVPNNVDLSKFDGFVLYGKRKPILMCFLCKLSFGYVRSFVTHAVHDHRMTLSEDERKILSNKNISAIIQGIGKDKEPLVSFLEPKNKNFQHPLVSTANLIGPGHSFYGKFSGIRMEGEEALPAGSAAGPEQPQAGLLTPSTLLNLGGLTSSVLKTPITSVPLGPLASSPTKSSEGKDSGAAEGEKQEVGDGDCFSEKVEPAEEEAEEEEEEEEAEEEEEEEEEEEEEEEDEGCKGLFPSELDEELEDRPHEEPGAAAGSSSKKDLALSNQSISNSPLMPNVLQTLSRGTASTSSNSASSFVVFDGANRRNRLSFNSEGVRANVAEGGRRLDFADESANKDNATAPEPNESTEGDDGGFVPHHQHAGSLCELGVGECPSGSGVECPKCDTVLGSSRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKSGQPHPRLARGESYTCGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNMQNLQNGGGEQVFSHTAGAAAAAVAAAAAAANISSSCGAPSPTKPKTKPTWRCEVCDYETNVARNLRIHMTSEKHMHNMMLLQQNMTQIQHNRHLGLGSLPSPAEAELYQYYLAQNMNLPNLKMDSAASDAQFMMSGFQLDPAGPMAAMTPALVGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESGVEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSETAADPEELAKDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTAEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPLCQDMLNNKIHLQLHLTHLHSVAPDCVEKLIMTVTTPEMVMPSSMFLPAAVPDRDGNSNLEEAGKQPETSEDLGKNILPSASTEQSGDLKPSPADPGSVREDSGFICWKKGCNQVFKTSAALQTHFNEVHAKRPQLPVSDRHVYKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLCQRSFRTFQALKKHLETSHLELSEADIQQLYGGLLANGDLLAMGDPTLAEDHTIIVEEDKEEESDLEDKQSPTGSDSGSVQEDSGSEPKRALPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLKRALQESATGQPEPTSSPDNKPFKCNTCNVAYSQSSTLEIHMRSVLHQTKARAAKLEAASGSSNGTGNSSSISLSSSTPSPVSTSGSNTFTTSNPSSAGIAPSSNLLSQVPTESVGMPPLGNPIGANIASPSEPKEANRKKLADMIASRQQQQQQQQQQQQQQQQQQQAQTLAQAQAQVQAHLQQELQQQAALIQSQLFNPTLLPHFPMTTETLLQLQQQQHLLFPFYIPSAEFQLNPEVSLPVTSGALTLTGTGPGLLEDLKAQVQVPQQSHQQILPQQQQNQLSIAQSHSALLQPSQHPEKKNKLVIKEKEKESQRERDSAEGGEGNTGPKETLPDALKAKEKKELAPGGGSEPSMLPPRIASDARGNATKALLENFGFELVIQYNENKQKVQKKNGKTDQGENLEKLECDSCGKLFSNILILKSHQEHVHQNYFPFKQLERFAKQYRDHYDKLYPLRPQTPEPPPPPPPPPPPPLPAAPPQPASTPAIPASAPPITSPTIAPAQPSVPLTQLSMPMELPIFSPLMMQTMPLQTLPAQLPPQLGPVEPLPADLAQLYQHQLNPTLLQQQNKRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITSLEELKIDSRPPSPEPPKQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARKNYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLVFQRIFDLIKHQKKLCYKDEDEEGQDDSQNEDSMDAMEILTPTSSSCSTPMPSQAYSAPAPSANNTASSAFLQLTAEAEELATFNSKTEAGDEKPKLAEAPSAQPNQTQEKQGQPKPELQQQEQPEQKTNTPQQKLPQLVSLPSLPQPPPQAPPPQCPLPQSSPSPSQLSHLPLKPLHTSTPQQLANLPPQLIPYQCDQCKLAFPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPSNPLLASQLLSGAIPQIPASSATSPSTPTSTMNTLKRKLEEKASASPGENDSGTGGEEPQRDKRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSFSHLPPSSSDGQGVPLSPVSKTMELSPRTLLSPSSIKVEGIEDFESPSMSSVNLNFDQTKLDNDDCSSVNTAITDTTTGDEGNADNDSATGIATETKSSSAPNEGLTKAAMMAMSEYEDRLSSGLVSPAPSFYSKEYDNEGTVDYSETSSLADPCSPSPGASGSAGKSGDSGDRPGQKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKSKLSMAKHFGINQTSYEGPKTECTLCGIKYSARLSVRDHIFSQQHISKVKDTIGSQLDKEKEYFDPATVRQLMAQQELDRIKKANEVLGLAAQQQGMFDNTPLQALNLPTAYPALQGIPPVLLPGLNSPSLPGFTPSNTALTSPKPNLMGLPSTTVPSPGLPTSGLPNKPSSASLSSPTPAQATMAMGPQQPPQQQQQQQQPQVQQPPPPPAAQPPPTPQLPLQQQQQRKDKDSEKVKEKEKAHKGKGEPLPVPKKEKGEAPTATAATISAPLPTMEYAVDPAQLQALQAALTSDPTALLTSQFLPYFVPGFSPYYAPQIPGALQSGYLQPMYGMEGLFPYSPALSQALMGLSPGSLLQQYQQYQQSLQEAIQQQQQRQLQQQQQQKVQQQQPKASQTPVPPGAPSPDKDPAKESPKPEEQKNTPREVSPLLPKLPEEPEAESKSADSLYDPFIVPKVQYKLVCRKCQAGFSDEEAARSHLKSLCFFGQSVVNLQEMVLHVPTGGGGGGSGGGGGGGGGGGGGGSYHCLACESALCGEEALSQHLESALHKHRTITRAARNAKEHPSLLPHSACFPDPSTASTSQSAAHSNDSPPPPSAAAPSSASPHASRKSWPQVVSRASAAKPPSFPPLSSSSTVTSSSCSTSGVQPSMPTDDYSEESDTDLSQKSDGPASPVEGPKDPSCPKDSGLTSVGTDTFRL", "length": 3703 }, "evidence": [ { "id": "E1BPV9", "url": "https://omabrowser.org/oma/group/E1BPV9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q61329-1", "protein_name": "Zinc finger homeobox protein 3", "gene_name": "Zfhx3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGCDSPVVSGKDNGCGIPQHRQWTELNSAHLPDKPSSMEQPTGESHGPLDSLRAPFNERLADSSTSAGPPAEPASKEVSCNECSASFSSLQTYMEHHCPGTHPPPALREESASDTSEEGEEESDVENLAGEIVYQPDGSAYIVESLSQLAQSGAACGSSSGSGAVPSLFLNSLPGVGGKQGDPSCAAPVYPQIINTSHIASSFGKWFEGSDPAFPNTSALAGLSPVLHSFRVFDVRHKSNKDYLNSDGSAKSSCVSKDVPNNVDLSKFDGFVLYGKRKPILMCFLCKLSFGYVRSFVTHAVHDHRMTLSEEERKLLSNKNISAIIQGIGKDKEPLVSFLEPKNKNFQHPLVSTGNLIGPGHSFYGKFSGIRMEGEEALPAVAAAGPEQPQAGLLTPSTLLNLGGLTSSVLKTPITSVPLGPLASSPTKSSEGKDSGAAEGDKQESGGHQDCFSEKVEPAEEEEAEEEEEEEEEAEEEEEEEEEEEEEEEEASKGLFPNDLEEELEDSPSEESGPPAGGTTKKDLALSNPSISNSPLMPNVLQTLSRGPASTTSNSASNFVVFDGANRRSRLSFNSEGVRANVAEGRRLDFADESANKDSATAPEPNESTEGDDGGFVPHHQHAGSLCELGVGESPSGSGVECPKCDTVLGSSRSLGGHMTMMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKSGQPHPRLARGESYTCGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNMQNLQNGGGEQVFSHSAGAAAAAAAAAAAAANIGSSWGAPSPTKPKTKPTWRCEVCDYETNVARNLRIHMTSEKHMHNMMLLQQNMTQIQHNRHLGLGSLPSPAEAELYQYYLAQNMNLPNLKMDSTASDAQFMMSGFQLDPTGPMAAMTPALVGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESGVEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEPVEDAEGPSEASADPEELAKDQGSGSEEGQSKRAASSSQAEKELTDSPATTKRTSFPGSSETPLSSKRPKASEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPLLRCPLCQDMLNNKIHLQLHLTHLHSVAPDCVEKLIMTVTAPEMVMPSSMFLPAAAADRDGNSTLEEVGKQPEASEDPGKNILPPASMEHGGDLKPTSADPSCGREDSGFLCWKKGCNQVFKTSATLQTHFNEVHAKRPQLPVSDRHVYKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLCQRSFRTFQALKKHLETSHLELSEADIQQLYGGLLANGDLLAMGDPTLAEDHTIIVEEDKEEESDLEDKQSPTGSDSGSVQEDSGSEPKRALPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLKRALQESATGQPEPTSSPDNKPFKCNTCNVAYSQSSTLEIHMRSVLHQTKARAAKLEAASGNSNGTGNSGGVSLSSSTPSPVGSSGANNTFTATNPSSAAMAPSVNALSQVPPESVVMPPLGNPISANIASPSEPKEANRKKLADMIASRQQQQQQQQQQQQQAQTLAQAQAQVQAHLQQELQQQAALIQSQLFNPTLLPHFPMTTETLLQLQQQQHLLFPFYIPSAEFQLNPEVSLPVTSGALTLTGSGPGLLEDLKVQVQIPQQSHQQILQQQQQQSQLSLSQSHSALLQPSQHPEKKNKVVIKEKDKESQREREGPEGAEGNTGPQESLPDASKAKEKKDLAPGGGSEGTMLPPRIASDARGNATKALLENFGFELVIQYNENKQKAQKKNGKAEQGGESLEKLECDSCGKLFSNILILKSHQEHVHQNYFPFKQLERFAKQYREHYDKLYPLRPQTPEPPPPPPPPPPPPLPTAPPQPASAPAIPASAPPITSPTIAPAQPSVPLTQLSMPMELPIFSPLMMQTMPLQTLPAQLPPQLGPVEPLPADLAQLYQHQLNPTLLQQQNKRPRTRITDDQLRVLRQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITSLEELKIDSRPPSPEPQKQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNARQKARKNYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLVFQRIFDLIKHQKKLCYKDEDEEGQDDSQNEDSMDAMEILTPTSSSCSTPMPSQAYSTPAPSAAAANTAPSAFLQLTAETDELATFNSKAEASDEKPKQADPPSAQPNQTQEKQGQPKPEMQQQLEQLEQKTNAPQPKLPQPAAPSLPQPPPQAPPPQCPLPQSSPSPSQLSHLPLKPLHTSTPQQLANLPPQLIPYQCDQCKLAFPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPSNPLLASQLLSGAIPQIPASSATSPSTPTSTMNTLKRKLEEKASASPGENDSGTGGEEPQRDKRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSFSHLPPSSSDGQGVPLSPVSKTMELSPRTLLSPSSIKVEGIEDFESPSMSSVNLNFDQTKLDNDDCSSVNTAITDTTTGDEGNADNDSATGIATETKSSAPNEGLTKAAMMAMSEYEDRLSSGLVSPAPSFYSKEYDNEGTVDYSETSSLADPCSPSPGASGSAGKSGDGGDRPGQKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKSKLSMAKHFGINQTSYEGPKTECTLCGIKYSARLSVRDHIFSQQHISKVKDTIGSQLDKEKEYFDPATVRQLMAQQELDRIKKANEVLGLAAQQQGMFDNAPLQALNLPTTYPALQGIPPVLLPGLNRPSLPGFTPANTALTSPKPNLMGLPSTTVPSPGLPTSGLPNKPSSASLSSPTPAQATMAMAPQPPPQPQQPQPPVQQPPPPPAAQQIPAPQLTPQQQRKDKDGEKGKEKEKAHKGKGEPLPVPKKEKGEAPPAGTGTISAPLPAMEYAVDPAQLQALQAALTSDPTALLTSQFLPYFVPGFSPYYAPQIPGALQSGYLQPMYGMEGLFPYSPALSRPLMGLSPGSLLQQYQQYQQSLQEAIQQQQQQQQQQQQQQQQQQRQLQQQQQQQQQKVQQQQQQQQQPKASQTPVPQGAASPDKDPAKESPKPEEQKNVPRELSPLLPKPPEEPEAESKSASADSLCDPFIVPKVQYKLVCRKCQAGFGDEEAARSHLKSLCCFGQSVVNLQEMVLHVPTGSGGGGGGGGGSGGGGGSYHCLACESALCGEEALSQHLESALHKHRTITRAARNAKEHPSLLPHSACFPDPSTASTSQSAAHSNDSPPPPSAAPSSSASPHASRKSWPPVGSRASAAKPPSFPPLSSSSTVTSSSCSTSGVQPSMPTDDYSEESDTDLSQKSDGPASPVEGPKDPSCPKDSGLTSVGTDTFRL", "length": 3726 }, "evidence": [ { "id": "E1BPV9", "url": "https://omabrowser.org/oma/group/E1BPV9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "response to transforming growth factor beta", "id": "GO:0071559", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071559", "evidence": [ { "database": "UniProtKB", "id": "E1BPV9", "url": "https://www.uniprot.org/uniprotkb/E1BPV9" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "E1BPV9", "url": "https://www.uniprot.org/uniprotkb/E1BPV9" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "E1BPV9", "url": "https://www.uniprot.org/uniprotkb/E1BPV9" } ], "pmid": "" }, { "name": "muscle organ development", "id": "GO:0007517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007517", "evidence": [ { "database": "UniProtKB", "id": "E1BPV9", "url": "https://www.uniprot.org/uniprotkb/E1BPV9" } ], "pmid": "" }, { "name": "regulation of neuron differentiation", "id": "GO:0045664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045664", "evidence": [ { "database": "UniProtKB", "id": "E1BPV9", "url": "https://www.uniprot.org/uniprotkb/E1BPV9" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "E1BPV9", "url": "https://www.uniprot.org/uniprotkb/E1BPV9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { 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"total": 3, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "E1BPY2", "url": "https://www.uniprot.org/uniprotkb/E1BPY2" } ], "pmid": "" }, { "name": "fusion of sperm to egg plasma membrane involved in single fertilization", "id": "GO:0007342", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007342", "evidence": [ { "database": "UniProtKB", "id": "E1BPY2", "url": "https://www.uniprot.org/uniprotkb/E1BPY2" } ], "pmid": "" }, { "name": "acrosomal vesicle exocytosis", "id": "GO:0060478", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060478", "evidence": [ { "database": "UniProtKB", "id": "E1BPY2", "url": "https://www.uniprot.org/uniprotkb/E1BPY2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 129, "end_pos": 131, "annotation": "n_glycosylation_sequon" }, { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BPY2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 323, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BPY2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BPY2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 119, "end_pos": 121 }, { "start_pos": 129, "end_pos": 131 }, { "start_pos": 164, "end_pos": 166 }, { "start_pos": 186, "end_pos": 188 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BQ05-1", "uniprot_ac": "E1BQ05", "uniprot_id": "E1BQ05_BOVIN", "mass": { "chemical_mass": 63998.0, "monoisotopic_mass": 63998.0 }, "refseq": { "ac": "NP_001192774", "name": "XK-related protein 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192774" }, "gene_names": [ { "name": "XKR7", "type": "recommended", "evidence": [ { "id": "E1BQ05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ05" } ] }, { "name": "XKR7", "type": "synonym", "evidence": [ { "id": "NP_001192774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192774" } ] } ], "protein_names": [ { "name": "XK-related protein", "type": "recommended", "evidence": [ { "id": "E1BQ05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ05/entry#names_and_taxonomy" } ] }, { "name": "XK, Kell blood group complex subunit-related family, member 7", "type": "synonym", "evidence": [ { "id": "NP_001192774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192774" } ] }, { "name": "XK-related protein 7", "type": "synonym", "evidence": [ { "id": "NP_001192774", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192774" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BQ05", "url": "https://www.uniprot.org/uniprotkb/E1BQ05" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "XKR7", "url": "https://www.uniprot.org/uniprotkb/E1BQ05", "locus": { "chromosome": "13", "start_pos": 61511791, "end_pos": 61487256, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016348", "url": "https://www.ensembl.org/id/ENSBTAG00000016348" } ] } } ], "crossref": [ { "id": "E1BQ05", "url": "https://alphafold.ebi.ac.uk/entry/E1BQ05", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016348", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016348", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "518090", "url": "https://www.ncbi.nlm.nih.gov/gene/518090", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018629", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018629", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050895", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050895", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:518090", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518090", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AMVQILW", "url": "https://omabrowser.org/oma/group/AMVQILW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BQ05", "url": "https://www.orthodb.org/?gene=E1BQ05", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16024", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16024", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16024:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16024:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09815", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09815", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192774", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BQ05", "url": "https://www.uniprot.org/uniprotkb/E1BQ05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BQ05-1", "url": "https://www.uniprot.org/uniprotkb/E1BQ05-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAKSDGAVAAAGPGPEEAAGGARGSAGGRGEAAEVAGGPGVTGAGGPGPRYELRDCCWVLCALLVFFSDGATDLWLAASYYLEGQHTYFGLTLLFVLLPSLVVQLLSFRWFVYDYTEPAGAPGPAVSTKDSGTGGPVISTKDSAVAFRTKEGSPELGSRPAPSSASTYRRRCCRLCIWLLQTLVHLLQLGQVWRYLRAMYLGLQSRWRGERLRRHFYWRMLFESADVSMLRLLETFLRSAPQLVLQLSLVVHEGGAPKLLPALSISASLVSLAWTLASYQKVLRDSRDDKRPLSYKGAVAQVLWHLFAIAARSLAFALFASVYKLYFGIFIVAHWCVMTFWVIQGETDFCMSKWEEIIYNMVVGIIYIFCWFNVKEGRSRHRVTLYYCIVLLENAALTGFWYSSRNFSTDFHSLILVCVVASSFALGVFFMCVYYCLLHPNGPMLSPQAPGCIFRKAPGPCGPPADAVTSPPRSLPRTTGPERDGASVGGERAGTPTPPVFQVRPGLPPTPVARTLRTEGPVIRIDLPRKKYPAWDAHFIDRRLRKTILALEYSSPTTPRLQYRSVGISQELLEYETTV", "length": 580, "header": "tr|E1BQ05-1|E1BQ05_BOVIN Isoform 1 of XK-related protein OS=Bos taurus OX=9913 GN=XKR7 PE=3 SV=1 CANONICAL=E1BQ05-1" }, "isoforms": [ { "isoform_ac": "E1BQ05-1", "url": "https://www.uniprot.org/uniprotkb/E1BQ05/entry", "sequence": { "sequence": "MAAKSDGAVAAAGPGPEEAAGGARGSAGGRGEAAEVAGGPGVTGAGGPGPRYELRDCCWVLCALLVFFSDGATDLWLAASYYLEGQHTYFGLTLLFVLLPSLVVQLLSFRWFVYDYTEPAGAPGPAVSTKDSGTGGPVISTKDSAVAFRTKEGSPELGSRPAPSSASTYRRRCCRLCIWLLQTLVHLLQLGQVWRYLRAMYLGLQSRWRGERLRRHFYWRMLFESADVSMLRLLETFLRSAPQLVLQLSLVVHEGGAPKLLPALSISASLVSLAWTLASYQKVLRDSRDDKRPLSYKGAVAQVLWHLFAIAARSLAFALFASVYKLYFGIFIVAHWCVMTFWVIQGETDFCMSKWEEIIYNMVVGIIYIFCWFNVKEGRSRHRVTLYYCIVLLENAALTGFWYSSRNFSTDFHSLILVCVVASSFALGVFFMCVYYCLLHPNGPMLSPQAPGCIFRKAPGPCGPPADAVTSPPRSLPRTTGPERDGASVGGERAGTPTPPVFQVRPGLPPTPVARTLRTEGPVIRIDLPRKKYPAWDAHFIDRRLRKTILALEYSSPTTPRLQYRSVGISQELLEYETTV", "length": 580, "header": "tr|E1BQ05-1|E1BQ05_BOVIN Isoform 1 of XK-related protein OS=Bos taurus OX=9913 GN=XKR7 PE=3 SV=1 CANONICAL=E1BQ05-1" }, "locus": { "chromosome": "13", "start_pos": 61511788, "end_pos": 61487256, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021750.5", "url": "https://www.ensembl.org/id/ENSBTAT00000021750.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021750.3", "url": "https://www.ensembl.org/id/ENSBTAP00000021750.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 498, "start_aa": "Thr", "end_pos": 498, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr498", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 511, "start_aa": "Thr", "end_pos": 511, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr511", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:518090", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518090", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YSZ7-1", "protein_name": "XK-related protein", "gene_name": "XKR7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAKSDGGGGGPAVRLESPEGGGGRRAGGATPPAQRYRLRDGCWVLCALLVCFADGASDLWLAADYYLEGQRWWFGLTLLFVLLPSLVVQLLSFRWFVYDFAVGTKDSAGSTKDSARGRRGCCRLCVWLLQGCIHLLQLGQVWRYLRTLYLGLQSRWQAEHRRRHFYWRMMFENADISMLRLLETFLKSAPQLVLQLSIMVQQNNIKALQGFSASASLVSLAWMIASYQKVLRDSREDKMPMSYKGAVVQILWHLFTIAARAIAFALFASVFQLYFGIFIVTHWCIMTFWIIQGETDFCMSKWEEIIYNMVVGIIYIFCWFNVKEGRSRYRMCIYYIITLSENAALTILWFHYYNRKTMSDFNALILVCVVSSSFALGIFFMFIYYCLLHPNGPMFGPSSGGCIFRQRPPPAPSSPADAVTSPPRSLPRTTGGEREGAPGERDSCVPVFQVRPCAPTPPAARAPRTEGPVIRIDLPRKKYPAWDAHFIDRRLRKTILALEYASPSTPRLQYRTAGVSQELLEYETTV", "length": 527 }, "evidence": [ { "id": "E1BQ05", "url": "https://omabrowser.org/oma/group/E1BQ05/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q5GH56-1", "protein_name": "XK-related protein 7", "gene_name": "Xkr7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAKSDGAAAVAGPGPEGPAGADRGGAGGRGEVAAGIAGPGPVEAGCPGPRYELRDCCWVLCALLVFFSDGATDLWLAASYYLQGQSTYFGLTLLFVLLPSLVVQLLSFRWFVYDYSEPTGTPGPAVSTKDSDIVGAAISTKDSAVAFRTKEGSPELVPRPAPSSAGAYRRRCCRLCVWLLQTLVHLLQLGQVWRYLRALYLGLQSRWRGERLRRHFYWRMLFESADVSMLRLLETFLRSAPQLVLQLSLLVHRGREPELLTALSISASLVSLAWTLASYQKVLRDSRDDKRPLSYKGAVVQVLWHLFTIAARTLAFALFASVYRLYFGIFIVAHWCIMTFWVIQGETDFCMSKWEEIIYNMVVGIIYIFCWFNVKEGRSRRRVTLYYCIVLLENAALTGFWYSSRNFSTDFYSLILVCVVASSFALGIFFMCVYYCLLHPNGPMLGPQAPGCIFPEAPGPCGPPADAITSPPRSLPRTTGAERDGAAVGGERAGTPTPPVFQVRPGLPPTPVARPLRTEGPVIRIDLPRKKYPAWDAHFIDRRLRKTILALEYSSPATPRLQYRSMGTSQELLEYETTV", "length": 580 }, "evidence": [ { "id": "E1BQ05", "url": "https://omabrowser.org/oma/group/E1BQ05/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5GH64-1", "protein_name": "XK-related protein 7", "gene_name": "Xkr7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAKSDGAAAVAGPGPEGPAGADRGGAGGRGEAAAGIAGPGPVEAGCPGPRYELRDCCWVLCALLVFFSDGATDLWLAASYYLQGQSTYFGLTLLFVLLPSLVVQLLSFRWFVYDYSEPAGTPGPAVSTKDSDIVGAAISTKDSAVAFRTKEGSAELVPRPAPSSAGTYRRRCCRLCVWLLQTLVHLLQLGQVWRYLRALYLGLQSRWRGERLRRHFYWQMLFESADVSMLRLLETFLRSAPQLVLQLSLLVHRGREPELLTALSISASLVSLAWTLASYQKVLRDSRDDKRPLSYKGAVVQVLWHLFTIAARTLAFALFASVYKLYFGIFIVAHWCIMTFWVIQGETDFCMSKWEEIIYNMVVGIIYIFCWFNVKEGRSRRRVTLYYCIVLLENAALTGFWYSSRNFSTDFYSLILVCVVASSFALGIFFMCVYYCLLHPNGPMLGPQAPGCIFPEAPGPCGPPADAITSPPRSLPRTTGTERDGVAVGGERAGTPTLPVFQVRPGLPPTPVARPLRTEGPVIRIDLPRKKYPAWDAHFIDRRLRKTILALEYSSPATPRLQYRSMGTSQELLEYETTV", "length": 580 }, "evidence": [ { "id": "E1BQ05", "url": "https://omabrowser.org/oma/group/E1BQ05/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5GH72-1", "protein_name": "XK-related protein 7", "gene_name": "XKR7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAKSDGAAASASPDPEGAAGGARGSAGGRGEAAAAAGPPGVVGAGGPGPRYELRDCCWVLCALLVFFSDGATDLWLAASYYLQNQHTYFSLTLLFVLLPSLVVQLLSFRWFVYDYSEPAGSPGPAVSTKDSVAGGAAISTKDSAGAFRTKEGSPEPGPQPAPSSASAYRRRCCRLCIWLLQTLVHLLQLGQVWRYLRALYLGLQSRWRGERLRRHFYWQMLFESADVSMLRLLETFLRSAPQLVLQLSLLVHRGGAPDLLPALSTSASLVSLAWTLASYQKVLRDSRDDKRPLSYKGAVAQVLWHLFSIAARGLAFALFASVYKLYFGIFIVAHWCVMTFWVIQGETDFCMSKWEEIIYNMVVGIIYIFCWFNVKEGRSRRRMTLYHCIVLLENAALTGFWYSSRNFSTDFYSLIMVCVVASSFALGIFFMCVYYCLLHPNGPMLGPQAPGCIFRKASEPCGPPADAITSPPRSLPRTTGAERDGASAGERAGTPTPPVFQVRPGLPPTPVARTLRTEGPVIRIDLPRKKYPAWDAHFIDRRLRKTILALEYSSPATPRLQYRSVGTSQELLEYETTV", "length": 579 }, "evidence": [ { "id": "E1BQ05", "url": "https://omabrowser.org/oma/group/E1BQ05/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "E1BQ05", "url": "https://www.uniprot.org/uniprotkb/E1BQ05" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "engulfment of apoptotic cell", "id": "GO:0043652", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043652", "evidence": [ { "database": "UniProtKB", "id": "E1BQ05", "url": "https://www.uniprot.org/uniprotkb/E1BQ05" } ], "pmid": "" }, { "name": "phosphatidylserine exposure on apoptotic cell surface", "id": "GO:0070782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070782", "evidence": [ { "database": "UniProtKB", "id": "E1BQ05", "url": "https://www.uniprot.org/uniprotkb/E1BQ05" } ], "pmid": "" }, { "name": "apoptotic process involved in development", "id": "GO:1902742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902742", "evidence": [ { "database": "UniProtKB", "id": "E1BQ05", "url": "https://www.uniprot.org/uniprotkb/E1BQ05" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-E1BQ05-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 580, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-E1BQ05-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/E1BQ05" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 498, 511 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 407, "end_pos": 409 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BQ10-1", "uniprot_ac": "E1BQ10", "uniprot_id": "E1BQ10_BOVIN", "mass": { "chemical_mass": 85863.0, "monoisotopic_mass": 85863.0 }, "refseq": { "ac": "XP_002690554", "name": "cadherin-24", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690554" }, "gene_names": [ { "name": "CDH24", "type": "recommended", "evidence": [ { "id": "E1BQ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ10" } ] }, { "name": "CDH24", "type": "synonym", "evidence": [ { "id": "XP_002690554", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690554" } ] } ], "protein_names": [ { "name": "Cadherin-24", "type": "recommended", "evidence": [ { "id": "E1BQ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ10/entry#names_and_taxonomy" } ] }, { "name": "cadherin-24", "type": "synonym", "evidence": [ { "id": "XP_002690554", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690554" } ] } ], "function": [ { "annotation": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.", "evidence": [ { "database": "UniProtKB", "id": "E1BQ10", "url": "https://www.uniprot.org/uniprotkb/E1BQ10#function" }, { "database": "UniProtKB", "id": "ARBA00055489", "url": "https://www.uniprot.org/uniprotkb/ARBA00055489#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BQ10", "url": "https://www.uniprot.org/uniprotkb/E1BQ10" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDH24", "url": "https://www.uniprot.org/uniprotkb/E1BQ10", "locus": { "chromosome": "10", "start_pos": 21811921, "end_pos": 21801532, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011349", "url": "https://www.ensembl.org/id/ENSBTAG00000011349" } ] } } ], "crossref": [ { "id": "E1BQ10", "url": "https://alphafold.ebi.ac.uk/entry/E1BQ10", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011349", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011349", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535046", "url": "https://www.ncbi.nlm.nih.gov/gene/535046", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000233", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000233", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039808", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039808", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535046", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535046", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FETRHSY", "url": "https://omabrowser.org/oma/group/FETRHSY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BQ10", "url": "https://www.orthodb.org/?gene=E1BQ10", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24027:SF272", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24027:SF272", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01049", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01049", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-418990", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418990", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002690554", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690554", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E1BQ10", "url": "https://www.uniprot.org/uniprotkb/E1BQ10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E1BQ10-1", "url": "https://www.uniprot.org/uniprotkb/E1BQ10-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHASAPRSSEQSLGWSPNMWGLVRLLLAWLGGWGCMGRLAAPARAWAGSRGGPEPSLLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLVGRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDSQGRDGLLTVRKPLDFETRRAYSFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLAVPENKAPGTLVGQVSATDLDSPASPIRYSILPHSDLERCFSIEPEDGTIRTAGPLDREARVWHNLTVLATELDSSAQASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPSQLIQVIRALDRDEVGNNSRVSFHGPLGPDANFTVRDNQDGSASLLLPSRPAPPRQAPYLVPIELWDWGQPVLSSTATVTVSVCRCRPDGSVASCRPEAQLSPAGLSTGALLAIVTCVGTLLALVVLFVALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFDISALQNPDGAAPPAPGPPARRDVLPWARAPRQPRPPGPADVAQLLALRLREADEDPSVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEIGGAPGPAEPLDDWGPLFRTLAELYGAKEPPAP", "length": 799, "header": "tr|E1BQ10-1|E1BQ10_BOVIN Isoform 1 of Cadherin-24 OS=Bos taurus OX=9913 GN=CDH24 PE=4 SV=3 CANONICAL=E1BQ10-1" }, "isoforms": [ { "isoform_ac": "E1BQ10-1", "url": "https://www.uniprot.org/uniprotkb/E1BQ10/entry", "sequence": { "sequence": "MHASAPRSSEQSLGWSPNMWGLVRLLLAWLGGWGCMGRLAAPARAWAGSRGGPEPSLLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLVGRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDSQGRDGLLTVRKPLDFETRRAYSFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLAVPENKAPGTLVGQVSATDLDSPASPIRYSILPHSDLERCFSIEPEDGTIRTAGPLDREARVWHNLTVLATELDSSAQASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPSQLIQVIRALDRDEVGNNSRVSFHGPLGPDANFTVRDNQDGSASLLLPSRPAPPRQAPYLVPIELWDWGQPVLSSTATVTVSVCRCRPDGSVASCRPEAQLSPAGLSTGALLAIVTCVGTLLALVVLFVALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFDISALQNPDGAAPPAPGPPARRDVLPWARAPRQPRPPGPADVAQLLALRLREADEDPSVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEIGGAPGPAEPLDDWGPLFRTLAELYGAKEPPAP", "length": 799, "header": "tr|E1BQ10-1|E1BQ10_BOVIN Isoform 1 of Cadherin-24 OS=Bos taurus OX=9913 GN=CDH24 PE=4 SV=3 CANONICAL=E1BQ10-1" }, "locus": { "chromosome": "10", "start_pos": 21811401, "end_pos": 21803371, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015083.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015083.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015083.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015083.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:535046", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535046", "resource": "KEGG Pathway" }, { "id": "R-BTA-418990", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418990", "resource": "Reactome", "description": "Adherens junctions interactions" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZTI3-1", "protein_name": "Cadherin-24", "gene_name": "Cdh24", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWGLVRLLLAWLGGWGCMGRLAAPVPAWAGSRGHSGPTLLRTRRSWVWNQFFVIEEYSGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPVFPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLVGRLKAQDPDLGDNALMAYSILDGEGSEAFSISTDSQGQDGLLTVRKPLDFETRRSYTFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQATYHLVVPENKAPGTLVGQISANDLDSPASPIRYSILPHSDPEHCFSIEPEDGTIRTAVRLDREARVWYNLTVLATELDSSAQSSRVQVAIQTLDENDNAPQLAEPYDLFVCDSAAPGQLIQVIRALDRDEVGNSSQVSLQGPVGPDANFTVRDNRDGSASLLLPSRPAPPRQAPYLVPIELWDWGQPALSSTATVTVSVCRCQPDGSRAPCWPEAQLSPTGLSTGALLAIVTCMGTLLALVVLFVALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFDITALQNPDGAAPPAAGPPVRRDVLPRTRAPRQPRPPGPADVAQLLALRLREADEDPSVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEAGGVPGPAEPLDDWGPLFRTLAELYGAKEPPAP", "length": 781 }, "evidence": [ { "id": "E1BQ10", "url": "https://omabrowser.org/oma/group/E1BQ10/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S9C8-1", "protein_name": "Cadherin-24", "gene_name": "CDH24", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWGLVRLLLAWLGGWGCMGRLAAPARAWAGSRGGPGPALLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLVGRLQAQDPDLGDNALMAYSILDGEGSEAFSISTDSQGRDGLLTVRKPLDFENRRSYSFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFSQAAYHLSVPENKAPGTLVGQVSASDLDSPASPIRYSILPHSDPERCFSIEPEDGTIRTAVPLDREARVWHNLTVLATELDSSAQASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSRVSLQGPLGPDANFTVRDNRDGSASLLLPSRPAPPRQAPYLVPIELWDWGQPALSSTATVTVSVCRCRPDGSVASCRPEAQLSPTGLSTGALLAIITCVGTLLALVVLFVALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFDISALQNPDGAAPPAPGPPARRDVLPWARAPRQPRPPGPADVAQLLALRLREADDDPSVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEIGGAPGPAEPLDDWGPLFRTLAELYGAKEPPAP", "length": 781 }, "evidence": [ { "id": "E1BQ10", "url": "https://omabrowser.org/oma/group/E1BQ10/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6PFX6-1", "protein_name": "Cadherin-24", "gene_name": "Cdh24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWGLVRLLLAWLGGWGCMGRLAAPVPAWAGSRGHSGPTLLRTRRSWVWNQFFVIEEYSGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPVFPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLVGRLKAQDPDLGDNALVAYSILNGEGSEVFSISTDSQGQDGLLTVRKPLDFETRRSYTFRVEATNTLIDPAYLRRGPFKDVASVRVTVQDAPEPPAFTQATYHLAVPENKAPGTLVGQISASDLDSPASPIRYSILPHSDPERCFSIEPEDGTIRTAVRLDREARVWHNLTILATELDSSAQSSRVQVAIQTLDENDNAPQLAEPYDIFVCDSAAPGQLIKVIRALDRDEVGNSSQVSLQGPVGPDANFTVRDNRDGSASLLLPSRPAPPRQAPYLIPIELWDWGQPALSSTATVTVSVCRCRPDGSMASCWPEAQLSPTGLSTGALLAIVTCMGTLLALVVLFVALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFDITALQNPDGAAPPAAGPPVRRDVLPRTRAPRQPRPPGPADVVQLLALRLREADEDPSVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEAGGVPGPAEPLDDWGPLFRTLAELYGAKEPPAP", "length": 781 }, "evidence": [ { "id": "E1BQ10", "url": "https://omabrowser.org/oma/group/E1BQ10/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86UP0-1", "protein_name": "Cadherin-24", "gene_name": "CDH24", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWGLVRLLLAWLGGWGCMGRLAAPARAWAGSREHPGPALLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLVGRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDFESQRSYSFRVEATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPENKAPGTLVGQISAADLDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREARAWHNLTVLATELGWSWGPERGWVPLLVAEWSAPAAPPQRSPVGSAVGIPQDSSAQASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSHVSFQGPLGPDANFTVQDNRDGSASLLLPSRPAPPRHAPYLVPIELWDWGQPALSSTATVTVSVCRCQPDGSVASCWPEAHLSAAGLSTGALLAIITCVGALLALVVLFVALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFDITALQNPDGAAPPAPGPPARRDVLPRARVSRQPRPPGPADVAQLLALRLREADEDPGVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEAGGAPGPAEPLDDWGPLFRTLAELYGAKEPPAP", "length": 819 }, "evidence": [ { "id": "E1BQ10", "url": "https://omabrowser.org/oma/group/E1BQ10/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "E1BQ10", "url": "https://www.uniprot.org/uniprotkb/E1BQ10" } ], "pmid": "" }, { "name": "catenin complex", "id": "GO:0016342", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016342", "evidence": [ { "database": "UniProtKB", "id": "E1BQ10", "url": "https://www.uniprot.org/uniprotkb/E1BQ10" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "E1BQ10", "url": "https://www.uniprot.org/uniprotkb/E1BQ10" } ], "pmid": "" }, { "name": "cell 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"calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0016339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016339", "evidence": [ { "database": "UniProtKB", "id": "E1BQ10", "url": "https://www.uniprot.org/uniprotkb/E1BQ10" } ], "pmid": "" }, { "name": "cell-cell adhesion mediated by cadherin", "id": "GO:0044331", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044331", "evidence": [ { "database": "UniProtKB", "id": "E1BQ10", "url": "https://www.uniprot.org/uniprotkb/E1BQ10" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "E1BQ10", "url": "https://www.uniprot.org/uniprotkb/E1BQ10" } ], "pmid": "" }, { "name": "cadherin binding", "id": "GO:0045296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296", "evidence": [ { "database": "UniProtKB", "id": "E1BQ10", 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"tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "E1BQ27-1", "uniprot_ac": "E1BQ27", "uniprot_id": "E1BQ27_BOVIN", "mass": { "chemical_mass": 40928.0, "monoisotopic_mass": 40928.0 }, "refseq": { "ac": "XP_005219335", "name": "prostacyclin receptor isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219335" }, "gene_names": [ { "name": "PTGIR", "type": "recommended", "evidence": [ { "id": "E1BQ27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ27" } ] }, { "name": "PTGIR", "type": "synonym", "evidence": [ { "id": "XP_005219335", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219335" } ] } ], "protein_names": [ { "name": "Prostacyclin receptor", "type": "recommended", "evidence": [ { "id": "E1BQ27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ27/entry#names_and_taxonomy" } ] }, { "name": "Prostaglandin I2 receptor", "type": "synonym", "evidence": [ { "id": "E1BQ27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ27/entry#names_and_taxonomy" } ] }, { "name": "Prostanoid IP receptor", "type": "synonym", "evidence": [ { "id": "E1BQ27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ27/entry#names_and_taxonomy" } ] }, { "name": "prostacyclin receptor isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005219335", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219335" } ] } ], "function": [ { "annotation": "Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.", "evidence": [ { "database": "UniProtKB", "id": "E1BQ27", "url": "https://www.uniprot.org/uniprotkb/E1BQ27#function" }, { "database": "UniProtKB", "id": "ARBA00060229", "url": "https://www.uniprot.org/uniprotkb/ARBA00060229#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BQ27", "url": "https://www.uniprot.org/uniprotkb/E1BQ27" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PTGIR", "url": "https://www.uniprot.org/uniprotkb/E1BQ27", "locus": { "chromosome": "18", "start_pos": 53752075, "end_pos": 53755483, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014585", "url": "https://www.ensembl.org/id/ENSBTAG00000014585" } ] } } ], 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"MADSCRNLTYVRDSVGPATSTLMFVAGVVGNGLALGILGARRQSRPSAFAVLVTGLAVTDLLGTCFLSPAVFAAYARNSSLLGLARGRPALCDAFAFAMTFFGLASTLILFAMAVERCLALSHPYLYAQLDGPRRARLALPAIYAFCTIFCSLPFLGLGQHQQYCPGSWCFIRMRSAEPGGCAFSLAYASLVALLVAAIVLCNGSVTLSLCRMYRQQRRHQGSLVPGPRAGEDEVDHLILLALMTGIMAVCSLPLTIRGFTQAIAPDSSEMGDLLAFRFNAFNPILDPWVFILFRKSVFQRLKLWFCCLYSRPAQGDSRTSLSQSASGRKDSSAPPALEGKKGNWVPLSAWGEGQGGPLPAVQLPTSTVGTPSKAGSEAACSLC", "length": 384, "header": "tr|E1BQ27-1|E1BQ27_BOVIN Isoform 1 of Prostacyclin receptor OS=Bos taurus OX=9913 GN=PTGIR PE=3 SV=2 CANONICAL=E1BQ27-1" }, "isoforms": [ { "isoform_ac": "E1BQ27-1", "url": "https://www.uniprot.org/uniprotkb/E1BQ27/entry", "sequence": { "sequence": 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376905" }, "gene_names": [ { "name": "OR4C175", "type": "recommended", "evidence": [ { "id": "E1BQ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ36" } ] }, { "name": "OR4C175", "type": "synonym", "evidence": [ { "id": "NP_001376905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376905" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "E1BQ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ36/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 4C46", "type": "synonym", "evidence": [ { "id": "NP_001376905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376905" } ] }, { "name": "olfactory receptor family 4 subfamily C member 175", "type": "synonym", "evidence": [ { "id": "NP_001376905", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376905" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376905" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "E1BQ36", "url": "https://www.uniprot.org/uniprotkb/E1BQ36#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "E1BQ36", "url": "https://www.uniprot.org/uniprotkb/E1BQ36" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4C175", "url": "https://www.uniprot.org/uniprotkb/E1BQ36", "locus": { "chromosome": "15", "start_pos": 883313, "end_pos": 884242, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000068191", "url": "https://www.ensembl.org/id/ENSBTAG00000068191" } ] } } ], "crossref": [ { "id": "E1BQ36", "url": "https://alphafold.ebi.ac.uk/entry/E1BQ36", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000054290", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054290", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15939", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15939", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515790", "url": "https://www.ncbi.nlm.nih.gov/gene/515790", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515790", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515790", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CVNTPKV", "url": "https://omabrowser.org/oma/group/CVNTPKV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "E1BQ36", "url": "https://www.orthodb.org/?gene=E1BQ36", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ 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"sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MAT8-1", "uniprot_ac": "F1MAT8", "uniprot_id": "F1MAT8_BOVIN", "mass": { "chemical_mass": 66582.0, "monoisotopic_mass": 66582.0 }, "refseq": { "ac": "XP_010808141", "name": "interleukin-18 receptor accessory protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808141" }, "gene_names": [ { "name": "IL18RAP", "type": "recommended", "evidence": [ { "id": "F1MAT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAT8" } ] }, { "name": "IL18RAP", "type": "synonym", "evidence": [ { "id": "XP_010808141", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808141" } ] } ], "protein_names": [ { "name": "Interleukin-18 receptor accessory protein", "type": "recommended", "evidence": [ { "id": "F1MAT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAT8/entry#names_and_taxonomy" } ] }, { "name": "Accessory 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"name": "interleukin-18 receptor accessory protein", "type": "synonym", "evidence": [ { "id": "XP_010808141", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808141" } ] } ], "function": [ { "annotation": "Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells.", "evidence": [ { "database": "UniProtKB", "id": "F1MAT8", "url": "https://www.uniprot.org/uniprotkb/F1MAT8#function" }, { "database": "UniProtKB", "id": "ARBA00058813", "url": "https://www.uniprot.org/uniprotkb/ARBA00058813#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MAT8", "url": "https://www.uniprot.org/uniprotkb/F1MAT8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL18RAP", "url": "https://www.uniprot.org/uniprotkb/F1MAT8", "locus": { "chromosome": "11", "start_pos": 7233882, "end_pos": 7208994, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033748", "url": "https://www.ensembl.org/id/ENSBTAG00000033748" } ] } } ], "crossref": [ { "id": "F1MAT8", "url": "https://alphafold.ebi.ac.uk/entry/F1MAT8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033748", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033748", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "493716", "url": "https://www.ncbi.nlm.nih.gov/gene/493716", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015621", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015621", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041416", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041416", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:493716", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:493716", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YPHIIQD", "url": "https://omabrowser.org/oma/group/YPHIIQD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11890", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11890", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11890:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11890:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01582", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01582", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18452", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18452", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9012546", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9012546", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010808141", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808141", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MAT8", "url": "https://www.uniprot.org/uniprotkb/F1MAT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MAT8-1", "url": 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"sequence": { "sequence": "MRLSLGWILLWLVARGRIRGLNTPDCITEKPLRTYSARCGEEFVLFCDLPEPQKSHFYHGSQLSPTRASEYLPCSGSKNLSDVQWYLQPQNGDAAVEITQNAPQVIQEKSNLHFLSTGINHAGLYICRPRMRSPQENACCVRMILEVKPQTNMSCESSVSHKQHLLLGSVSSIYCPGLSHQSDAQSPEVTWYQNGKLLSEKRSNPIEVDEVYYYHQGTYVCDYTQTDNSSSWTVRAVVHVKTIVKNTNLKPDILDPIKDTLEVELGKPLMLNCTARFGFEINFNPVIKWYIRDSDQEWEIKTPKGRSVKSTLKDEVIERVVLLEKVTQSDLHRKFICFAQNSIGNTTQSIQLKKKTGVVFLYILLGAVMGLAGVLTAGALLYMYWIEIVLVYRTYWSKDKTLGDQKEFDAFVSYAKWSPFETEASSSLSEETLALNLLPDVLENKYGYTLCLLERDVAPGGVYTEDIVSIIKKSRRGIFILSPNYVSGPSIFELQAAVNLALEDQTLKLILIKFSSFQEPESLPHLVRRALRVLPSVTWKGLKSVPPNSRFWTQIRYHMPVKSSRGVTWNHLRTMPWIFSLEKTQ", "length": 585, "header": "tr|F1MAT8-1|F1MAT8_BOVIN Isoform 1 of Interleukin-18 receptor accessory protein OS=Bos taurus OX=9913 GN=IL18RAP PE=3 SV=2 CANONICAL=F1MAT8-1" }, "locus": { "chromosome": "11", "start_pos": 7233330, "end_pos": 7209122, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047919.4", "url": "https://www.ensembl.org/id/ENSBTAT00000047919.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045070.3", "url": "https://www.ensembl.org/id/ENSBTAP00000045070.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:493716", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:493716", "resource": "KEGG Pathway" }, { "id": "R-BTA-9012546", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9012546", "resource": "Reactome", "description": "Interleukin-18 signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K2K7-1", "protein_name": "Interleukin-18 receptor accessory protein", "gene_name": "Il18rap", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLCLGWVFLWFVAGEKTTGFNHSACTTKKLLWTYSARGAENFVLFCDLQELQKQDFSHRSQSSSTLGPAHQPCSGSEKDLSDVQWYMQPRSGGPLEEINRNSPHMQNKGTLRILAPQMNSIWSYICRPRSRRPQDTACCVKTVLEVKPQRNISCGSSAQDEQVLLLGSTGSIHCPSLSCQSDVRSPEMTWYKDGRLLPEYKKNPIEMEDIYDFHQGLYVCDYTQSDNVSSWTVRAVVQVRTIDEDTNVKPDILDPVTDTLDVELGKAFTLPCRVQFGFQRYSKPVIKWYVKESTQEWEISEFVEKRIQSTLKNEVIEHTVFLREVTQRDLSRKFVCFAQNSIGNTTRTIRLRKKEGVVFLYILLGMTVMLVGVLVAAALLYWHWIEVVLLCRTFKNKDETLRDKKEFDAFVSYANWSSPETEATGSLSEEHLALNLFPEVLENTYGYSLCLFERDVTPGGVYTDDIVSIIKRSRRGIFILSPRYINGPRVFELQAAVNLALVDQTLKLILIKFCSFQEPESLPYLVKKALRVLPTVTWKGLKSVHATSRFWTQIRYHMPVKNSNRFMFNWLRLIPKGFSPEKDLATQKPLGGMPNSGNSHGAQNRTPDAGNRHGAQNLLLSGHQKRC", "length": 627 }, "evidence": [ { "id": "F1MAT8", "url": "https://omabrowser.org/oma/group/F1MAT8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0YFL8-1", "protein_name": "Interleukin 18 receptor accessory protein", "gene_name": "IL18RAP", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRPPPFGDRDPLHQLSCSREFSAESPTRLLGFARDCHQYAFATWTESKTILKESLNSSEYQSKLIKKMMLTFYWILALLITGTEVRGINLPGCSHVKPQVWYRAISDEEFVLQCALPDKDATNIYNNSVLKQHEVKWFWHQKDKGHLKAVEESFNVTLQGNALWFKPVRENASGIYICMIREKIPCLKIVLEVQTKAKAKCSGYGTNTLYLLAGNGNSIACPGRKCYSHINKTDVRWYKDGRQVEYRKTRNSLQLVDNEIYLKITYVQDAGIYVCDYDMSDNTTQWTMRTAVTVEVIAKTTIHPPNILYPSSVAILEAELGKPLELECRVQFGFERGTQRVIWKRDNKENLNEKLKQFETIETKETSVCPRYLKGHVLRHVAKLEEVTERDLKSDFICFAQNSVGNATAVIQLKKKQRVFFLYILCSAISILFAFLLCTAFIYQHWIEIVLMYRSYVAHNETTGDGKEFDAFVSYAKTDASESDSAFISEEKFALEILPDVLENKYGYKLCILERDILPGGAYTDEVVTAIRQSRRTIIILSPAYVSGPNIFELQAAVNCALEDKKIKLVLIKFQAFQEPETLPPVVKKALRILPVITWKPSISPAPNKKFWKYMHYHMPMNTTKVLGSCSLKCFFQRLFSLEHR", "length": 645 }, "evidence": [ { "id": "F1MAT8", "url": "https://omabrowser.org/oma/group/F1MAT8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O95256-1", "protein_name": "Interleukin-18 receptor accessory protein", "gene_name": "IL18RAP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLCLGWIFLWLVAGERIKGFNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW", "length": 599 }, "evidence": [ { "id": "F1MAT8", "url": "https://omabrowser.org/oma/group/F1MAT8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z2B1-1", "protein_name": "Interleukin-18 receptor accessory protein", "gene_name": "Il18rap", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLCLGWVFLWFVAGEKTTGFNHSACATKKLLWTYSARGAENFVLFCDLQELQEQKFSHASQLSPTQSPAHKPCSGSQKDLSDVQWYMQPRSGSPLEEISRNSPHMQSEGMLHILAPQTNSIWSYICRPRIRSPQDMACCIKTVLEVKPQRNVSCGNTAQDEQVLLLGSTGSIHCPSLSCQSDVQSPEMTWYKDGRLLPEHKKNPIEMADIYVFNQGLYVCDYTQSDNVSSWTVRAVVKVRTIGKDINVKPEILDPITDTLDVELGKPLTLPCRVQFGFQRLSKPVIKWYVKESTQEWEMSVFEEKRIQSTFKNEVIERTIFLREVTQRDLSRKFVCFAQNSIGNTTRTIRLRKKEEVVFVYILLGTALMLVGVLVAAAFLYWYWIEVVLLCRTYKNKDETLGDKKEFDAFVSYSNWSSPETDAVGSLSEEHLALNLFPEVLEDTYGYRLCLLDRDVTPGGVYADDIVSIIKKSRRGIFILSPSYLNGPRVFELQAAVNLALVDQTLKLILIKFCSFQEPESLPYLVKKALRVLPTVTWKGLKSVHASSRFWTQIRYHMPVKNSNRFMFNGLRIFLKGFSPEKDLVTQKPLEGMPKSGNDHGAQNLLLYSDQKRC", "length": 614 }, "evidence": [ { "id": "F1MAT8", "url": "https://omabrowser.org/oma/group/F1MAT8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "interleukin-18 receptor complex", "id": "GO:0045092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045092", "evidence": [ { "database": "UniProtKB", "id": "F1MAT8", "url": "https://www.uniprot.org/uniprotkb/F1MAT8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MAT8", "url": "https://www.uniprot.org/uniprotkb/F1MAT8" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "F1MAT8", "url": "https://www.uniprot.org/uniprotkb/F1MAT8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "F1MAT8", "url": "https://www.uniprot.org/uniprotkb/F1MAT8" } ], "pmid": "" }, { "name": "interleukin-18-mediated signaling pathway", "id": "GO:0035655", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035655", "evidence": [ { "database": "UniProtKB", "id": "F1MAT8", "url": "https://www.uniprot.org/uniprotkb/F1MAT8" } ], "pmid": "" }, { "name": "immune system process", "id": "GO:0002376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002376", "evidence": [ { "database": "UniProtKB", "id": "F1MAT8", "url": "https://www.uniprot.org/uniprotkb/F1MAT8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "coreceptor activity", "id": "GO:0015026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015026", "evidence": [ { "database": "UniProtKB", "id": "F1MAT8", "url": "https://www.uniprot.org/uniprotkb/F1MAT8" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "F1MAT8", "url": "https://www.uniprot.org/uniprotkb/F1MAT8" } ], "pmid": "" }, { "name": "interleukin-18 receptor activity", "id": "GO:0042008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042008", "evidence": [ { "database": "UniProtKB", "id": "F1MAT8", "url": "https://www.uniprot.org/uniprotkb/F1MAT8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 228, "end_pos": 230, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MAT8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 585, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MAT8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MAT8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MAT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAT8" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 149, "end_pos": 239, "start_aa": "Pro", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MAT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAT8" }, { "id": "PS50104", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50104" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TIR", "eco_id": "ECO_0000259", "start_pos": 406, "end_pos": 559, "start_aa": "Lys", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 152, "end_pos": 154 }, { "start_pos": 228, "end_pos": 230 }, { "start_pos": 272, "end_pos": 274 }, { "start_pos": 345, "end_pos": 347 }, { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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} ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MAZ4-1", "uniprot_ac": "F1MAZ4", "uniprot_id": "F1MAZ4_BOVIN", "mass": { "chemical_mass": 52809.0, "monoisotopic_mass": 52809.0 }, "refseq": { "ac": "XP_059739235", "name": "chordin-like protein 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739235" }, "gene_names": [ { "name": "CHRDL1", "type": "recommended", "evidence": [ { "id": "F1MAZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ] }, { "name": "CHRDL1", "type": "synonym", "evidence": [ { "id": "XP_059739235", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739235" } ] } ], "protein_names": [ { "name": "Chordin like 1", "type": "synonym", "evidence": [ { "id": "F1MAZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4/entry#names_and_taxonomy" } ] }, { "name": "chordin-like protein 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059739235", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739235" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CHRDL1", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4", "locus": { "chromosome": "X", "start_pos": 59037905, "end_pos": 59168291, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004432", "url": "https://www.ensembl.org/id/ENSBTAG00000004432" } ] } } ], "crossref": [ { "id": "F1MAZ4", "url": "https://alphafold.ebi.ac.uk/entry/F1MAZ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004432", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004432", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100336905", "url": "https://www.ncbi.nlm.nih.gov/gene/100336905", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045717", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045717", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR46303", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46303", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46303:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46303:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00093", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00093", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19548", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19548", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23334", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23334", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-201451", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201451", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059739235", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739235", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MAZ4-1", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRKKWKMGCMGGMRYIFSLLLFFLFLEGSRTEQVKHSETYCVFQDKKYRVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPSLHCLSPVHVPHLCCPRCPEDSLPPANNKMTSKSCEYNGTTYQHGELFMAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDGELSWEHSDGDIFRQPANREARHSYHRSHYDPPPSRQAGGLPRFPGARSHRGALMDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVCPGKKAKEELPGQSFDSKGYFCGEETMPVYESVFMEDGETTRKIALETERPPQVEVHVWTIRKGILQHFHIEKISKRMFEELHHFKLVTRTTLSQWKIFTEGEAQISQMCSSRVCRTELEDLVKVLYLERSEKGHC", "length": 462, "header": "tr|F1MAZ4-1|F1MAZ4_BOVIN Isoform 1 of Chordin like 1 OS=Bos taurus OX=9913 GN=CHRDL1 PE=4 SV=3 CANONICAL=F1MAZ4-1" }, "isoforms": [ { "isoform_ac": "F1MAZ4-1", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4/entry", "sequence": { "sequence": "MRKKWKMGCMGGMRYIFSLLLFFLFLEGSRTEQVKHSETYCVFQDKKYRVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPSLHCLSPVHVPHLCCPRCPEDSLPPANNKMTSKSCEYNGTTYQHGELFMAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDGELSWEHSDGDIFRQPANREARHSYHRSHYDPPPSRQAGGLPRFPGARSHRGALMDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVCPGKKAKEELPGQSFDSKGYFCGEETMPVYESVFMEDGETTRKIALETERPPQVEVHVWTIRKGILQHFHIEKISKRMFEELHHFKLVTRTTLSQWKIFTEGEAQISQMCSSRVCRTELEDLVKVLYLERSEKGHC", "length": 462, "header": "tr|F1MAZ4-1|F1MAZ4_BOVIN Isoform 1 of Chordin like 1 OS=Bos taurus OX=9913 GN=CHRDL1 PE=4 SV=3 CANONICAL=F1MAZ4-1" }, "locus": { "chromosome": "X", "start_pos": 59168239, "end_pos": 59040034, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005810.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005810.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005810.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005810.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-201451", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201451", "resource": "Reactome", "description": "Signaling by BMP" }, { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "embryonic axis specification", "id": "GO:0000578", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000578", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "pmid": "" }, { "name": "excitatory chemical synaptic transmission", "id": "GO:0098976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098976", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "pmid": "" }, { "name": "regulation of synaptic plasticity", "id": "GO:0048167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048167", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "pmid": "" }, { "name": "BMP signaling pathway", "id": "GO:0030509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030509", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "pmid": "" }, { "name": "negative regulation of BMP signaling pathway", "id": "GO:0030514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "pmid": "" }, { "name": "AMPA glutamate receptor clustering", "id": "GO:0097113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097113", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "pmid": "" }, { "name": "eye development", "id": "GO:0001654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001654", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "pmid": "" }, { "name": "synapse maturation", "id": "GO:0060074", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060074", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transforming growth factor beta binding", "id": "GO:0050431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050431", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "pmid": "" }, { "name": "BMP binding", "id": "GO:0036122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036122", "evidence": [ { "database": "UniProtKB", "id": "F1MAZ4", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 296, "end_pos": 298, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MAZ4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 462, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MAZ4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MAZ4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MAZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ4" }, { "id": "PS50184", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50184" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFC", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 104, "start_aa": "Thr", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 123, "end_pos": 125 }, { "start_pos": 296, "end_pos": 298 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MB15-1", "uniprot_ac": "F1MB15", "uniprot_id": "F1MB15_BOVIN", "mass": { "chemical_mass": 760589.0, "monoisotopic_mass": 760589.0 }, "refseq": {}, "gene_names": [ { "name": "FSIP2", "type": "recommended", "evidence": [ { "id": "F1MB15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB15" } ] } ], "protein_names": [ { "name": "Fibrous sheath interacting protein 2", "type": "synonym", "evidence": [ { "id": "F1MB15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB15/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MB15", "url": "https://www.uniprot.org/uniprotkb/F1MB15" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FSIP2", "url": "https://www.uniprot.org/uniprotkb/F1MB15", "locus": { "chromosome": "2", "start_pos": 10562877, "end_pos": 10705287, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003645", "url": "https://www.ensembl.org/id/ENSBTAG00000003645" } ] } } ], "crossref": [ { "id": "ENSBTAG00000003645", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003645", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR031554", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031554", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038891", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038891", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RKTECFS", "url": "https://omabrowser.org/oma/group/RKTECFS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MB15", "url": "https://www.orthodb.org/?gene=F1MB15", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21856", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21856", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21856:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21856:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15783", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15783", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MB15", "url": "https://www.uniprot.org/uniprotkb/F1MB15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB15-1", "url": "https://www.uniprot.org/uniprotkb/F1MB15-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELYISACSKAADVAATKTATSGLTTESQQCGDGEHKTQFSGVGAAQLLDLPLGVKLPVIPGSNSLYYTTKLNEKLFRPSYGFNLTDPYCRLLENQYKSLHDPHLRAYHQRKDILRRLKKGGYITSNNKVVCTLRELNKYRQYLTSLKLDFERNYIREQKMLAKQVNKLQEDNQIPGRSDVTQFQNWLLQEGTPSIKDQERLIRHRYLDMIRRELEHLEHTAEEQRLLRMDREERRQREHARRKLSLRRKIEEEWKTKEMLLLTRIGEDVKREARIEEQRRKSREESDKKKQALLEKKMAYHLQKMQESGIKKEDMRKNTNDYGEQDGLHYESIYPKKKKKKNDDIKVVYAVADQKPNRGADVDSYMIFFSFLLASNQVTSEELNSIIQNIMTWVVATVTSILYPAITKYEERLKNNTYPVSDDSVLSSDSSSFCSTCSEEFTYGSYTSATTKSFKREPCAFAVDISVRRPTTPLKPSAHVEKAVVGKTCHITGQSVTNELKHNETNMVYTYPDLRSCKSDSHLLASLETDTKKSKDATTETDGLENPPFSDQKAKAVNEMKNLKNVFVNFKCHLKGETELILESIFQEIMSDLTHAIPSISSVTAEVFVDQSEPVRGDLVSNTDICSVASEIVENMLEKLQSAVEKKCVQIYSQEDLPVNIQPSLTPSGESLTLSYGKPLIASVPSTAEPMCDVAEDMVHAILEKLMTLTANKQSKLPHLEEATKLSHQQHMTDPTYMCHIKANKNKCNPELDAANVIVKEKIQNLMSNILSQSSLVGYIEEAISTILGYVQTELNNERLIASEETVVLLKLLDDIFTQLHQEPVKAGNQKCRHSRLRSPSNTDVKYRLTGTRFSNGPRSGRPFPPINVPGMVLYSEDDNEEVDRIVENVLDSSFKDEKAKPQEQISEHWFTKGSTCLEFQRNSKLPTKPASPRSKATFHSCRLRTELPFFKDRKILKEKPCLNKDILFFSQDQKHQIQKASENTVKSILTEMLKDISSVPPGHLESRTDKASVHVSEKPQEPLHQEWMDQLFSVSEISTVAQEITDTILNILQKASCIPSTTKSSISSSVHPASLESPDTLHMVKAAPNKKPLKIWFDSEKKMKYLSSLDGDMAKPSLLKSKESEPKPADEITDKIINAVFKKLKLFICPKLQMGFKPSLADKSSLQSQLSTYTAKVVNIVLRAIQNELELSEKNLNLRERNYTKSLTGKGCFTDTKKLESLVSDLNDDIMESPLLTCICEILSSGHPDQSNISLSSDNSKPTASHGSDKVDKGNILPSRQDKKSFYKILATPCALHSVINGKDLKENSRLQVLDNIGETLYEMLCKLIGAHPHCQPSCSKVSREKTNKNQQRATELQSNIQLISTTILEYIIAKLCSVDTDTSSVSSGCKATSESLDIDNLSLTSIIEEMAKCTDIISSIVSRMVQEGDKEITKSTEKPIAPKSSKTGSAKEMHSNKLKAVASDILNMVFAKLEGFANGNLETLDSTNDENKKSSKMNVECESFSVFTDTHEELLQSALYTNAKKVSSAILKAIQTELNMNSLDLRTSVETPPPEKQMLENIVSLILDAVSSDMLNETESEERDSETYGYRPIYGNFLPGGAESDSFLEDATNAEKEFIGEEIPLREETQSNSLQQWVLERTLNKLEVKLKEPQKSPIVPIIRNILNEIFQNALVSQLNMLFLSHSLLSDIPPNVDKPIAQTSVPFIDKMMVSEADVTIVADDVVTTVFDKLYTAAKTETIASENSYKTITFSANVSFHEHTYGRGKPSITALNKNPYTLQSRFNIGRQAKGNIVEDIVQAILTSLETFVTSKVESLFCPQINFTVPMALPVQQGKSTISKALSAKDLYSEGQLSSCSVDNVMSQNTNSFCQVSLNKLNIYATEVARKILKGIKNELDKEKETPFLTNNIVVSESITRQIVNTVLDIVSSKGKCDKNSFDKEISSDQQEGIIEKLFKKIEYRKVLQFQIQDTIESVLCDIYEKTLNQNNLSFATPTLKCTIAGKHSRANSDTEGVNKILPKFSVPKSDVILISNDIVDVVLHNLSSAVMLSINAKDPTSTRLPLTFCDTFSKLQCQQSLLTVSESERKTEHFPSSKILKPAYVNDSQITIVEKEDPKKSVPDPCEESANFITQNIFNWLESFATERIDSFIMLAFQPKEKSFVRPELENCKQDGIIFHEPSQVESNVNILKISNETILSQELTDSTFASYREKLGSTIHLSQAHLKEYSDIIASAILNFIKNDLDLEIQKMHPYPNNVSFQEITIVSEIVNGILKSLHNKRAAKDISFSSKDNPNLFSQLTASNEISLGQKAQEKKTKLSLFSKYPLEQNQMALERESQRIILEELFMRNENSKQKERTALFSAVEEVLSKVYQKIIEIIGHLPSFNEKSHFNSKTSDITQNNFCQSHINSTASDIIENVLGNMYSVIMTSLYENNEGEPADKNILPKKSPCIKETKAGIGSSVTRFVLPQVYHYADSQNISLLENTFLRYSPSQVGKDLIQVVLSKITNFASFYLEETVSHENCSDELQPLRLHSSKVSPKPSVKTSLKARSKVTPLPKLRTKPHIGPSRAKAKSRTKSSPGEKTPKDVWSKTDIGLPHILSTGDAKNLLEMKLPTSQLKMYAKDIISNILKTTIKELEKVTRARAMISNRALPSDQIMAANKIVTTVLQGLYAINNHSSANPVKFSHLDETKRSRGNEGAESLARPQACFYLENVSSQLEQIFPKEGIFKKMFDKWQAESNDMENEKCKLLMIAENDLTEISIKAKELEYSLLLLNLPHLEDCENRFYSCFKGASTRAENNKAQINMFGREIVEMLLEKLQLCFLSQMTTPYGKETAANRKEHITTKSKYGFPAKDILSNVPVYNTKTKDQSALGSSNQIVREIVERVLNILESFVDLQFKHISKYEFSEIVKMPIENLFPVQQRLLSKKMLPKLQPLKKFSDESKSSTIVSKENVQNTLLQVHSFHSELLTYAVNIVHNMLGVIKNKLDKEISQVEPSSVSTLKENTAASEIIGTLMDQCAHFSESLIKNLPKENFFQGVENTYIVNQVELATDTKMPMSKLKEVSFGNNLPQSSVPDLGFYSEENMKKRYKSSSNLPSYSRASVEDTVRNSEPMRRPDSENRPSSSRNKVQDTIPKESDLGYFDQAMKGNSSLPEGSVLQKLLKKANESTETALKQVMSFIEMRKGENPRVFHYEISKPVIEPNQIQTSVSPLKICLAAENIVSTVLSSYGFPNQPHINESTETMKPFFISKQDPLSETSGGQKNEEKSLLRMWDKRISYILEEENKKAEVKREDFSLLQKWENKSYLKIKTLKEVEVIAFADHELGPNEIHLVSRHVTTSVVTYFKNFETRVSSEKVSIVSTLSRKKYESKSPLRSIYSDSSLHQFCEHLTESVICHLMSSISGSTTDITEKEKTSERQNAAFNTIISIDSQVFESRSISVGELALSISEIITEILLNSNIIETDIAQQMFSLTRKYTYCPGVSAADFDDLFQDLLIGVIHVLSKEIGLNHHLENSGRNRPFPMLRSNSMPICNRRNTMQRQKGSRDWGLATHQIDHIIQKNKLNYLAHKLDSLAGSLKTHESKEIVNRVFSIVLDLFLPDEQPDEAMGSEIKARTFFSSSYEGQYNNILGNNLGLSPKSVFLLNVVCEKLIRTLLEKCTNSVFLDNFPLSEEVSAEECQLLKILQSVDEEFDYCNGTMDWEQFQGDYTSDILENLAEMDPDLLSTDSMLTIISHSLVKSLMDKLHHSIQLPQSPPFANKHLKCGTREIQPSCIKAKRPELTELEQGRGSLGCMSYYGHALTGPLNNPSVVSSKIQAPFGKKYSVNFANVPPLKRQGAKDMNTIAIHNTLYPGDMNTGVYSATFLEDIISELFFNLSISLLGKNENIMDAQLNEMNTLFVNSIVNEFNKARVTVLRNSEERLCFPPIHKETVSRIVDSVYYGVLQQYKSKVTCGGNLACDSTSIAEQITNSILLEILDYQLPSCFREKLLHNSYYPLNAEIILQKLQNNLREFTSKPRSLTDYSTMLSQSFLEDIIRRLLTQLIPPPSKASSLENKYFVSSDFNEMSTCIINKVISAISKHKIWFTIYDNQYLCTGKNLQKMVDSVYRNIMQTYDSLISIQKSILSRSPILVDRIASFIIQEIVENHLQPFLCGEGLPRPKTPSDAISNMVKQVLNEVIESHRPQTPAAAGIYTETFVREIVARLLSKIFSPKHNTEIELENMTQKIVNSVNNHFDKAKVHLLCNDKEQSYPSVDTDIVDELVTSVYRNVLKQYGLDPEFDKESEDSSIFVEKITNLVVAAISDYLFHPLFSGNLSSSYSLSTTDNIVQDILSNISGSTMPSQSLSPYNTLLPYTFLEDMIRVLLSRIFPSAHSIVANREIPKDRSKANFNEIASDIISDIRRKISQHEIRFSKDEEGTKFIYSEDDIHHLVDSVFKNILNSESQELVEPSVTSSNDVLIDRIAGFIIKYVCQQHLQPFVDGKSLPSSSYTYLGDERRQWFYASVYSSAFLEDVISGVLSKIFHRGLGIVQTKSVRDSEDELFDKAEKLVHFITEEFSRAKVSILENAEKNLCLPPVERDVVKNIIDTVYSKVVQEYEMEIMPDKNFLNDTKTLAAKITEIILAETSDFQIHPNLTEKLPFGSQSKLSSDILIKKVHHDITKSRSQRQASTIYTTMLSHTHLEKIVSQLISQMSPLVSSTEHQDTSQSDLSNTVIKLINEIMSIISKHAVCIIKHGNEKHSMISEKDIQSMVDSIYAALSCSSIYQSLTKDKKDINNIPVSKIASFIIKEIFNHHLQSFLSGDKTLLSAEVDQTYKQKVLDPKEKQLSFIMNSAVFLEEVISELLCKLLYAFSHNVLAAENPDIVKAKVTGIVTTLVKSIVLEFTTSEIFLADSFDADMCFSEGYKEMVQRTVSRTYEKILDEYKSLIQIYRAMQSDTACFGRKIYNFLLEEIYDCQVKSLISGELISSSSSSPQADKIIRNVLNVIMRDSHALPSCITVLPCSLLEDMIYKLLVHIFPLTDTESELKEEEVSDYEFVDAASKLTDEIIKEISEHEICLATAEENAESVQLEVIQDLINSICNNILKKSEFQAEVQKDANKNGGSFLSKIAGFIMKEIMDHHLQPFLHGEESSSNSLSNYDHVSVHTIPGKKKTQPSLYSATFLEDVIVDLVHKFYSLPSITEEIKEKEKPEPDVVSLAIKFANSLIGEFRKSEIKVLPNAEEMFSFPPIDKETVDKISDFVYDQFIETYGSNDIQKNGKNNIVTEMIATLAQKAISAFKIQPLFSGDWSSTFFSFLNPDNITQRVKHLPQQTSTQINRCLKENQLTLSEHLETKETSMKTGDIQDPVVTSVTSIMKSNVVNLLSGPGVANKENKNKMGIPVQKYNVSKVTCPTTKTKDKQEPYLKGTLKNNETDKKRISASDKEGQGKEVHTQILVATDGEREIFQLDFKIDNPLQLSSLIAKVRNTENTIEKPSEAVTQKPNDEERKDSSAQIDIKEGEYSDYELVQNVTENIYDSIFGMYHSQESADYLRQQSLPSHTASPITQALPVTQEIGKDFAQSVLTKGLSLSANKNLGAKEKEEKENASKIEKEREKKRGGERENDSVKVKDIKKEPSKPDSPQYPPEPAVFPAKFLEDVITEMVNKLIFSSSPETQTYDRCQNVCDDENQDELYDTAMRLIDSLLKEFSDAQVKVFRPDKEYQVFPPADKVSSVPKEYPRHKESNIDEAPCNVKTITMDKSHTMTEKPSSNKILFLDKMSSIDKTLVNKVVHASVCNILKEYKSQDSICKNIKNNGGHLARRLASAMINEIFQHKLNLILCDEFPVSSCLPLETKDVVKKVQKVAQTASKECQTSSPYTIMLPHEFLENVISTLLSKIFSTVSNTIAETYESSWFTELDFLQMKLLSTVTTEISKDEDMIIQYVESLHPSDDETIQLVVQSLYNNLLSQFGSQESIQNCAASGCRILSETIVDLIRREVTGNQLQNYFSGELTPYQCAEVDNVVENILKDVIQMADIPQPHPSQACILPYNIIEEIAVKFLSKLLSAFPKVNKERPKSLETEMQKITSKILNSIQEIISKNKIKVVSPAKEIPTAPLADNEAIEKVVNSVYTSILKHSGSLNSIFKDLMGKSNILSDIIGFLMVKEISKSKFQPQVQEELSGPELALEAVKIMEKVVKMVDEFKSQEKSSSKKGSMLDATFLEEALALFLAKIVRLPSDSSKHAKNLSKPELNKIASQLTKSVTAEISKSNINLVAADSEEHFLNPESIEMVSQVIDSIYSNVLQQSGTQKDLYHDIKSTNGVFPKKVANLIINEVSNFPFDSASPKNSNACFFGDLDINRIVEKAQEHAVNMIPDLNKESTKDSIVEDSAIKIVPHVGNKPLKIDPNIISEHLAVISIKTQPLEKLQTECLKNTGHSIAELRRASIGGRSYPSDTCTIRELKRERRTSLSKTGRLDIKPFEAVCRNSFQNIRKPDITKVELLKDVQNKKELILRLVAHDIEQEISESTIEEELTSSDEDEVVLREIVQEPSGENIEDQVKHSTKPVESKVVSPKPTQSTSSLKKFFSLSKCCQATSNANVENTGTVSNHVIEAKNGQIKRTVAELDMSPLEVFRDSVQKEEKILTTEPTHYFIHRIMSSSSYNQEDLISYARYMKLKQYKIVESVLCFVLQFITIFEGNKNILHSMNPSKEVISETSRSDVPKQGSKMLAKVSSALSKVFSRNINTNISKSSSPPHQNEH", "length": 6749, "header": "tr|F1MB15-1|F1MB15_BOVIN Isoform 1 of Fibrous sheath interacting protein 2 OS=Bos taurus OX=9913 GN=FSIP2 PE=4 SV=3 CANONICAL=F1MB15-1" }, "isoforms": [ { "isoform_ac": "F1MB15-1", "url": "https://www.uniprot.org/uniprotkb/F1MB15/entry", "sequence": { "sequence": "MELYISACSKAADVAATKTATSGLTTESQQCGDGEHKTQFSGVGAAQLLDLPLGVKLPVIPGSNSLYYTTKLNEKLFRPSYGFNLTDPYCRLLENQYKSLHDPHLRAYHQRKDILRRLKKGGYITSNNKVVCTLRELNKYRQYLTSLKLDFERNYIREQKMLAKQVNKLQEDNQIPGRSDVTQFQNWLLQEGTPSIKDQERLIRHRYLDMIRRELEHLEHTAEEQRLLRMDREERRQREHARRKLSLRRKIEEEWKTKEMLLLTRIGEDVKREARIEEQRRKSREESDKKKQALLEKKMAYHLQKMQESGIKKEDMRKNTNDYGEQDGLHYESIYPKKKKKKNDDIKVVYAVADQKPNRGADVDSYMIFFSFLLASNQVTSEELNSIIQNIMTWVVATVTSILYPAITKYEERLKNNTYPVSDDSVLSSDSSSFCSTCSEEFTYGSYTSATTKSFKREPCAFAVDISVRRPTTPLKPSAHVEKAVVGKTCHITGQSVTNELKHNETNMVYTYPDLRSCKSDSHLLASLETDTKKSKDATTETDGLENPPFSDQKAKAVNEMKNLKNVFVNFKCHLKGETELILESIFQEIMSDLTHAIPSISSVTAEVFVDQSEPVRGDLVSNTDICSVASEIVENMLEKLQSAVEKKCVQIYSQEDLPVNIQPSLTPSGESLTLSYGKPLIASVPSTAEPMCDVAEDMVHAILEKLMTLTANKQSKLPHLEEATKLSHQQHMTDPTYMCHIKANKNKCNPELDAANVIVKEKIQNLMSNILSQSSLVGYIEEAISTILGYVQTELNNERLIASEETVVLLKLLDDIFTQLHQEPVKAGNQKCRHSRLRSPSNTDVKYRLTGTRFSNGPRSGRPFPPINVPGMVLYSEDDNEEVDRIVENVLDSSFKDEKAKPQEQISEHWFTKGSTCLEFQRNSKLPTKPASPRSKATFHSCRLRTELPFFKDRKILKEKPCLNKDILFFSQDQKHQIQKASENTVKSILTEMLKDISSVPPGHLESRTDKASVHVSEKPQEPLHQEWMDQLFSVSEISTVAQEITDTILNILQKASCIPSTTKSSISSSVHPASLESPDTLHMVKAAPNKKPLKIWFDSEKKMKYLSSLDGDMAKPSLLKSKESEPKPADEITDKIINAVFKKLKLFICPKLQMGFKPSLADKSSLQSQLSTYTAKVVNIVLRAIQNELELSEKNLNLRERNYTKSLTGKGCFTDTKKLESLVSDLNDDIMESPLLTCICEILSSGHPDQSNISLSSDNSKPTASHGSDKVDKGNILPSRQDKKSFYKILATPCALHSVINGKDLKENSRLQVLDNIGETLYEMLCKLIGAHPHCQPSCSKVSREKTNKNQQRATELQSNIQLISTTILEYIIAKLCSVDTDTSSVSSGCKATSESLDIDNLSLTSIIEEMAKCTDIISSIVSRMVQEGDKEITKSTEKPIAPKSSKTGSAKEMHSNKLKAVASDILNMVFAKLEGFANGNLETLDSTNDENKKSSKMNVECESFSVFTDTHEELLQSALYTNAKKVSSAILKAIQTELNMNSLDLRTSVETPPPEKQMLENIVSLILDAVSSDMLNETESEERDSETYGYRPIYGNFLPGGAESDSFLEDATNAEKEFIGEEIPLREETQSNSLQQWVLERTLNKLEVKLKEPQKSPIVPIIRNILNEIFQNALVSQLNMLFLSHSLLSDIPPNVDKPIAQTSVPFIDKMMVSEADVTIVADDVVTTVFDKLYTAAKTETIASENSYKTITFSANVSFHEHTYGRGKPSITALNKNPYTLQSRFNIGRQAKGNIVEDIVQAILTSLETFVTSKVESLFCPQINFTVPMALPVQQGKSTISKALSAKDLYSEGQLSSCSVDNVMSQNTNSFCQVSLNKLNIYATEVARKILKGIKNELDKEKETPFLTNNIVVSESITRQIVNTVLDIVSSKGKCDKNSFDKEISSDQQEGIIEKLFKKIEYRKVLQFQIQDTIESVLCDIYEKTLNQNNLSFATPTLKCTIAGKHSRANSDTEGVNKILPKFSVPKSDVILISNDIVDVVLHNLSSAVMLSINAKDPTSTRLPLTFCDTFSKLQCQQSLLTVSESERKTEHFPSSKILKPAYVNDSQITIVEKEDPKKSVPDPCEESANFITQNIFNWLESFATERIDSFIMLAFQPKEKSFVRPELENCKQDGIIFHEPSQVESNVNILKISNETILSQELTDSTFASYREKLGSTIHLSQAHLKEYSDIIASAILNFIKNDLDLEIQKMHPYPNNVSFQEITIVSEIVNGILKSLHNKRAAKDISFSSKDNPNLFSQLTASNEISLGQKAQEKKTKLSLFSKYPLEQNQMALERESQRIILEELFMRNENSKQKERTALFSAVEEVLSKVYQKIIEIIGHLPSFNEKSHFNSKTSDITQNNFCQSHINSTASDIIENVLGNMYSVIMTSLYENNEGEPADKNILPKKSPCIKETKAGIGSSVTRFVLPQVYHYADSQNISLLENTFLRYSPSQVGKDLIQVVLSKITNFASFYLEETVSHENCSDELQPLRLHSSKVSPKPSVKTSLKARSKVTPLPKLRTKPHIGPSRAKAKSRTKSSPGEKTPKDVWSKTDIGLPHILSTGDAKNLLEMKLPTSQLKMYAKDIISNILKTTIKELEKVTRARAMISNRALPSDQIMAANKIVTTVLQGLYAINNHSSANPVKFSHLDETKRSRGNEGAESLARPQACFYLENVSSQLEQIFPKEGIFKKMFDKWQAESNDMENEKCKLLMIAENDLTEISIKAKELEYSLLLLNLPHLEDCENRFYSCFKGASTRAENNKAQINMFGREIVEMLLEKLQLCFLSQMTTPYGKETAANRKEHITTKSKYGFPAKDILSNVPVYNTKTKDQSALGSSNQIVREIVERVLNILESFVDLQFKHISKYEFSEIVKMPIENLFPVQQRLLSKKMLPKLQPLKKFSDESKSSTIVSKENVQNTLLQVHSFHSELLTYAVNIVHNMLGVIKNKLDKEISQVEPSSVSTLKENTAASEIIGTLMDQCAHFSESLIKNLPKENFFQGVENTYIVNQVELATDTKMPMSKLKEVSFGNNLPQSSVPDLGFYSEENMKKRYKSSSNLPSYSRASVEDTVRNSEPMRRPDSENRPSSSRNKVQDTIPKESDLGYFDQAMKGNSSLPEGSVLQKLLKKANESTETALKQVMSFIEMRKGENPRVFHYEISKPVIEPNQIQTSVSPLKICLAAENIVSTVLSSYGFPNQPHINESTETMKPFFISKQDPLSETSGGQKNEEKSLLRMWDKRISYILEEENKKAEVKREDFSLLQKWENKSYLKIKTLKEVEVIAFADHELGPNEIHLVSRHVTTSVVTYFKNFETRVSSEKVSIVSTLSRKKYESKSPLRSIYSDSSLHQFCEHLTESVICHLMSSISGSTTDITEKEKTSERQNAAFNTIISIDSQVFESRSISVGELALSISEIITEILLNSNIIETDIAQQMFSLTRKYTYCPGVSAADFDDLFQDLLIGVIHVLSKEIGLNHHLENSGRNRPFPMLRSNSMPICNRRNTMQRQKGSRDWGLATHQIDHIIQKNKLNYLAHKLDSLAGSLKTHESKEIVNRVFSIVLDLFLPDEQPDEAMGSEIKARTFFSSSYEGQYNNILGNNLGLSPKSVFLLNVVCEKLIRTLLEKCTNSVFLDNFPLSEEVSAEECQLLKILQSVDEEFDYCNGTMDWEQFQGDYTSDILENLAEMDPDLLSTDSMLTIISHSLVKSLMDKLHHSIQLPQSPPFANKHLKCGTREIQPSCIKAKRPELTELEQGRGSLGCMSYYGHALTGPLNNPSVVSSKIQAPFGKKYSVNFANVPPLKRQGAKDMNTIAIHNTLYPGDMNTGVYSATFLEDIISELFFNLSISLLGKNENIMDAQLNEMNTLFVNSIVNEFNKARVTVLRNSEERLCFPPIHKETVSRIVDSVYYGVLQQYKSKVTCGGNLACDSTSIAEQITNSILLEILDYQLPSCFREKLLHNSYYPLNAEIILQKLQNNLREFTSKPRSLTDYSTMLSQSFLEDIIRRLLTQLIPPPSKASSLENKYFVSSDFNEMSTCIINKVISAISKHKIWFTIYDNQYLCTGKNLQKMVDSVYRNIMQTYDSLISIQKSILSRSPILVDRIASFIIQEIVENHLQPFLCGEGLPRPKTPSDAISNMVKQVLNEVIESHRPQTPAAAGIYTETFVREIVARLLSKIFSPKHNTEIELENMTQKIVNSVNNHFDKAKVHLLCNDKEQSYPSVDTDIVDELVTSVYRNVLKQYGLDPEFDKESEDSSIFVEKITNLVVAAISDYLFHPLFSGNLSSSYSLSTTDNIVQDILSNISGSTMPSQSLSPYNTLLPYTFLEDMIRVLLSRIFPSAHSIVANREIPKDRSKANFNEIASDIISDIRRKISQHEIRFSKDEEGTKFIYSEDDIHHLVDSVFKNILNSESQELVEPSVTSSNDVLIDRIAGFIIKYVCQQHLQPFVDGKSLPSSSYTYLGDERRQWFYASVYSSAFLEDVISGVLSKIFHRGLGIVQTKSVRDSEDELFDKAEKLVHFITEEFSRAKVSILENAEKNLCLPPVERDVVKNIIDTVYSKVVQEYEMEIMPDKNFLNDTKTLAAKITEIILAETSDFQIHPNLTEKLPFGSQSKLSSDILIKKVHHDITKSRSQRQASTIYTTMLSHTHLEKIVSQLISQMSPLVSSTEHQDTSQSDLSNTVIKLINEIMSIISKHAVCIIKHGNEKHSMISEKDIQSMVDSIYAALSCSSIYQSLTKDKKDINNIPVSKIASFIIKEIFNHHLQSFLSGDKTLLSAEVDQTYKQKVLDPKEKQLSFIMNSAVFLEEVISELLCKLLYAFSHNVLAAENPDIVKAKVTGIVTTLVKSIVLEFTTSEIFLADSFDADMCFSEGYKEMVQRTVSRTYEKILDEYKSLIQIYRAMQSDTACFGRKIYNFLLEEIYDCQVKSLISGELISSSSSSPQADKIIRNVLNVIMRDSHALPSCITVLPCSLLEDMIYKLLVHIFPLTDTESELKEEEVSDYEFVDAASKLTDEIIKEISEHEICLATAEENAESVQLEVIQDLINSICNNILKKSEFQAEVQKDANKNGGSFLSKIAGFIMKEIMDHHLQPFLHGEESSSNSLSNYDHVSVHTIPGKKKTQPSLYSATFLEDVIVDLVHKFYSLPSITEEIKEKEKPEPDVVSLAIKFANSLIGEFRKSEIKVLPNAEEMFSFPPIDKETVDKISDFVYDQFIETYGSNDIQKNGKNNIVTEMIATLAQKAISAFKIQPLFSGDWSSTFFSFLNPDNITQRVKHLPQQTSTQINRCLKENQLTLSEHLETKETSMKTGDIQDPVVTSVTSIMKSNVVNLLSGPGVANKENKNKMGIPVQKYNVSKVTCPTTKTKDKQEPYLKGTLKNNETDKKRISASDKEGQGKEVHTQILVATDGEREIFQLDFKIDNPLQLSSLIAKVRNTENTIEKPSEAVTQKPNDEERKDSSAQIDIKEGEYSDYELVQNVTENIYDSIFGMYHSQESADYLRQQSLPSHTASPITQALPVTQEIGKDFAQSVLTKGLSLSANKNLGAKEKEEKENASKIEKEREKKRGGERENDSVKVKDIKKEPSKPDSPQYPPEPAVFPAKFLEDVITEMVNKLIFSSSPETQTYDRCQNVCDDENQDELYDTAMRLIDSLLKEFSDAQVKVFRPDKEYQVFPPADKVSSVPKEYPRHKESNIDEAPCNVKTITMDKSHTMTEKPSSNKILFLDKMSSIDKTLVNKVVHASVCNILKEYKSQDSICKNIKNNGGHLARRLASAMINEIFQHKLNLILCDEFPVSSCLPLETKDVVKKVQKVAQTASKECQTSSPYTIMLPHEFLENVISTLLSKIFSTVSNTIAETYESSWFTELDFLQMKLLSTVTTEISKDEDMIIQYVESLHPSDDETIQLVVQSLYNNLLSQFGSQESIQNCAASGCRILSETIVDLIRREVTGNQLQNYFSGELTPYQCAEVDNVVENILKDVIQMADIPQPHPSQACILPYNIIEEIAVKFLSKLLSAFPKVNKERPKSLETEMQKITSKILNSIQEIISKNKIKVVSPAKEIPTAPLADNEAIEKVVNSVYTSILKHSGSLNSIFKDLMGKSNILSDIIGFLMVKEISKSKFQPQVQEELSGPELALEAVKIMEKVVKMVDEFKSQEKSSSKKGSMLDATFLEEALALFLAKIVRLPSDSSKHAKNLSKPELNKIASQLTKSVTAEISKSNINLVAADSEEHFLNPESIEMVSQVIDSIYSNVLQQSGTQKDLYHDIKSTNGVFPKKVANLIINEVSNFPFDSASPKNSNACFFGDLDINRIVEKAQEHAVNMIPDLNKESTKDSIVEDSAIKIVPHVGNKPLKIDPNIISEHLAVISIKTQPLEKLQTECLKNTGHSIAELRRASIGGRSYPSDTCTIRELKRERRTSLSKTGRLDIKPFEAVCRNSFQNIRKPDITKVELLKDVQNKKELILRLVAHDIEQEISESTIEEELTSSDEDEVVLREIVQEPSGENIEDQVKHSTKPVESKVVSPKPTQSTSSLKKFFSLSKCCQATSNANVENTGTVSNHVIEAKNGQIKRTVAELDMSPLEVFRDSVQKEEKILTTEPTHYFIHRIMSSSSYNQEDLISYARYMKLKQYKIVESVLCFVLQFITIFEGNKNILHSMNPSKEVISETSRSDVPKQGSKMLAKVSSALSKVFSRNINTNISKSSSPPHQNEH", "length": 6749, "header": "tr|F1MB15-1|F1MB15_BOVIN Isoform 1 of Fibrous sheath interacting protein 2 OS=Bos taurus OX=9913 GN=FSIP2 PE=4 SV=3 CANONICAL=F1MB15-1" }, "locus": { "chromosome": "2", "start_pos": 10705287, "end_pos": 10562946, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047870.4", "url": "https://www.ensembl.org/id/ENSBTAT00000047870.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000045033.3", "url": "https://www.ensembl.org/id/ENSBTAP00000045033.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LHF7-1", "protein_name": "Fibrous sheath-interacting protein 2", "gene_name": "Fsip2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELYLSACSKTANVAANKAASSTVADDSQQCGDGAHKTPIPGVGAAQLLDLPLGVKLPMIPGTDTVYFTTNISEKLFRPSYGFNLTDPYCRLLETQYKSLHDPHLRTYYKRKDILRRLKKGGYITSNNKIVCSLRELNKYRQYLTSLKLDFERNYLREQQLISKQLHRLQETSQLPHCSDVTRFQNWLLQDNSQCIKDQERLLRHRYLDMISKELEQLERTAEEQRLLRMDREERRQREYARKKLSLRRKIEEEWKTKEMMLLTKIGEDVKREQRVEEQRRRSREESDRKKQAMLEKKMAYHLQKMQDTGLKDDMGRSGFEYKGQTMFESSPKKKKRPLDDIKVVYPDSDQKAYKGASGQVSSTVNQSQSSSKNVTKVSGSSVAYPADVQNSSSEQKRNGITKKLSDERVPGTTSTRDSVISAQESPTKNARLSQTSLIHHKEEKMQSDWNGRPSKKSSYVGEPGSQSCAPPPNIFSSPVYSNMQQNLQHCLKEKVTSEELNSIIQNIMTWVVATVTSILYPAITKYEERVQSNTYQVSDDSDLSSDSSSFCSTCSEGFTYRSYTAKTFQADPCAFATDVPLKKPPSPVKTPSAHVEKTVIDQTYEKKGQDIASQVNFNKTSLDYPFPKIGSSKSDSHLLTSLETCTKTSKDATTETESLEIPFLYDKKAKAMDEMKNLKNVFVNFKCHLKGETQLILESIFQEIMSDLSQAIPSLSSVTAEVFVDQTDAEREEFLSNVDICSVASEIVENMLEKLECAVERKYVQIFSQEDLSVEIKPSLSTSGEYFSSIETKPSEDTLSFTLEPMCDIADDMVHSILEKLMVLASYKKTEVSPEDSTKHFHQPTKTEPIHKVYQKTDQKKASPAFDASNLIAKEDIQNLISDIFSQSSLVGYVEEAISTILGYVQTELNNERLIASEETVVLLQLLDDVLTQLHQQPEKAAVKKQRRPRVRSFSESEEKYRLTGTTSFNNLRSKKPFPPVNVPGMVLYSEDDDEEIDNFVRSVLDSSFSDEKVKSPEQIPSHWPKRRDTCFESRRSSKPPTKSTFESRTKNRVESRDWGLKLELSLSSEDIVKTKHGLSGEASIFSQDQKHQIQKASENIVKHILTEMLKDISSDSSSHTGSQAGEEGSAFISDKFQGLSDQDWMEQIFSGSEICAFAHEITDSVINILHKASTYIPSTIKNAFTSVHHTYVDPSDTAHTSKETSSKVPFKIWFDSEKKVKYLSSLNMEQEKTSKLRSGKCEPKRVNDITDKIINTIFKRLKLFVCPKLQIGSKSPLIEKSFHSQLSTYTMKIVNIVLNAIQSELEMEKISPNLKETDQHKSRKNKGFFMDSNKVVESHVASVNDDIMESPLLACICEMIASTNENKKHTPTYTDKAVPTTTCGTGSAPKQNILSDKQQEKISFRELLAKPCLRHSFTDEEDFKDSSKLEVLDQIGETLHEMLSKLTGEHPDSQPSCSHQNKENLEKDLPTLSNVQLISKGILDYVLAKLCDIDIDTSIINSGLKTVSDTLDIENLSLASTMEEMAKCTNIISSIISNIMEENKDETKSKEKSDPPVSTKTEIPEEMCPQKLKNIASDILNAVFAKLENFANGSVEKVGAVDDETQKEHTVGWECESNSSPADSQDQSLQSTLYSHAKKVSSGILKAIQTELNVNPSDSKIDKKSSQEETQILTNIVDLILGVVSSDMFAEPESENTDNENYGYRPTYGNFLPGGAESDSFYDDETQDKELMSDTSLLREETRALSTDEMVLERTLSKIEVKLKEPHRSPIVPIIRNILNEIFQSALISQLNVVSLSRAHFGGMPHNAPASSTQTSSRFINQMMGPLVSDTDVSVVVNDVVRTVFHKLYSAAMTEKHVSENRCKTIIFSANVSFHERTYGRNGPASGLNGNACDLQSSWNVDKQTKINVVEDIVQSILGNLETFAASKVESLFCPQVNFTVPVTLPVQQEGGSLSQALSDKDSDSQLPCSLDHRNPEQMDPWCQRSLSKLNIYAKEVARKILQGIKHELDKEQDSPLLTNHIVVSENIASQVVNAVLDIVSCKTQGDKNSSDKESHSDQQAGIIERLVNKTEYRKILEFQIQDTIEGILCEIYGNIVHQNNLSFATPTPKYGVPTKCSEADFEPVVMGTNIIPKVSVPKADVILVSKDIVDIVLHNLTSLVMLAVNAKDSTSARLAFYDIFPKPPCQQPLSITQSTEGKPGHPSLLKSKNLGYPDVHPTPINGKEDTKEPAADPCEENANCITETIFNRLQSFATERINSLTTLAFQPEGNGFVNPQFQNDKDDNCIFHEPGQAESDVKVLKLSKNKTVPSQALAEPIFARCRENFGTTTHLSQTSLKDYAAVIASTILKLIKNDLDLELQSMHTYASHILFQKNMIVSEIVNNILKVLHNKETVKELLLSSSENSSCSQLTISNEVLLGHKEKEKTTPLPQFTANSLEESRITMEKESQRDVLEEIFMRRGDSKSRERTEILRTVEEVLKKLSQKIMDIIGHISPFNEIPYIVSKSKSKTAAVRHRKFFQSHINNVSNDILENVLGEMHSVVVTSLYKKNKGRREGEMHDTSGSSAGKAPCFRETKPTRKRIPQTHPYADNLNALVLENTFFPYLPSQIGKYLVQIVLDKLSNFVSLHLEEGYPPEGSYDDLYLLRIHNSKLSPKNSPRPGCKTSLKMRSKITSLSKFKTKPHLGISGTKTKSKTKLSAGEKTPRENRSKTALGLPQTPQAEDAKTTLKTKLPVAELRVYATNIITDILEVIMGSLERASQHRAMFNMKVLSSSQILEASKIVNAVLQELYATNNDNSDSPTNSSNPSDHRLAKQNLGAGYPSEQPCFYLENVSSQLEQIFPKEGILKKMFDKWQTETSDTETEKSKLLTVAENILTEISIKAKDLEYSLSLLNLPPLEECENRFYDRFKGGATRAEDTKAQINMFGREIVEMLFEKLQLCFLSQMPTQDGNGMLTCRKGPVAAKSKHGVQTKPILSGMQTCNLKMKDQVSMSRSNQIVHEIVERVLNMLESFVDLKFKHISKYEFSEIVKMPIDNLFQVQQRQLSKKMLPKLPSRKFGDECKSSAIISKENVQNTLLQVHLFHSELLTYSVTTVSGMLRIIKNKLDKEISQMEPSPVSLLKENMAASEIIGTLIDQCSHFSESLVKNLPTNNWFKGTENVYIVNQVEFAPSVKMPPGNMSDTPGRSNSPPRSVPGLEFTSDDDMKEKYNLASNSSSLISSYVENASKSSEAARRPSSRAMPSCSRHKTQDHSWRKPNSGPFEEVTKAHSFLPEGSVLQKLFKKVNDSTEESLKQVLSFIEMGKGENPRVFHYEATKPAEPKEIRTTASPLKICLAAENIVNTVLSSYGFPHQPGTSESTETMKPFFMSSQTPLSDICEGQKDMEKTLLTTWCTRMTDLLEEESESSETCQEDFSLLYKWKNKNSKTTTEASEEAYAIDFADHELGPNEMHLVARHVTTSVITHLKNLKTSVSTEKLFHISSLSKKNDDAKQPIKSIYSNSSVYQLCEHLSEAVICYLSSNLSDGTREGSKEKAWEIHDAILDKNILIHSQLHKTRSISIGDLALSIFEVIVEVLFYRNLINADKAHQASINAKYTLCPGVTSSDFDDMFQDLLKGVICVLSKVLGINHFENNVRNKSYAPLKSSLPILNKVNTMENHTGPRDLESSPHLTDHLVQKNKLNYLARRLNSLVGSLKSHESKEVVNEVFNIVLDLFLPDEFPDGDMSSGKLAKTFSPSNIQESHRTLTNNLGLSSKSVFLLNVVCEKLIRTLLEKCTGGAAFFEENTLLREVPEECQHVKVLSSVKGGGFDYLKTPTDCEQFQGDYMSDLLENLADIDQDSLSSDCILNVISHSLVKSLMDKLSHGLQQAPFENKYKNYRMKEIQPFVPKTIRQELIDPEQTKAHVGFMSSDNNFFTKSLNNPNATSFKMHTPFGKQHAGKTISLSFPDRKEARRINKVSSHKLCQRGVNGAVFSAIFLEEIIAELFFNLSTSLWKKNLNITEAWLNEINTLLINNVVKELNNAQISVLRYPEERLYFPSAHKGCITKIVDSIYLDVLQQYEFTVTSGNLPYDNAPVAERIANSILLEIIDYQLPSCFKGKLRSNLFHTLNAEIILYKLRNSLKKCNSEPMSSKGYSTMLPHSFLEYVIRRLLAQLIPLPVKSSSLDKTYWTSSDFSEMSNCITNKVMSAISKHKIWFTNCDNQYLHTDKNLQKMVDSVYSNILQMSDSLDLIQKNIISRSPIMIDQIASFIIQEIIESHLQPFLCGETLPRPKTPLDEVSYMVKQVINEVVESHKSRKTSPFGIYPDKFVGEVVTRVLSKIFSPKSKANVELENMTQKIVRSVNNHLDRAKIPILCDRQTSLPFSNTDTVDELVASVYRNVLKQHGLDPDIDESENGEVFVENITKFITAAISDYLLHPLFSGDLSASSCSSSMTDHTVYDILGDINKSSKSNQTLPLYNTLLPYTFLEDMIRVLLSKFFPSSPKIASYKAASKDKEGVNFNEIASNLISDIRRKISQHEIRFSKDEERTKSFYSEDDVQHLVDAVFTNILENSGSQESVEQNITKSNAVLIDQIAGFIIKYICEHHLQPFLERRQLSSSSRKYYDDDRQELLYGSAYSSMFLEDVVSGVVSKIFHRVVGIVQVDSTRNSENVLFDKAESLIYWITEEFSKAQVTTIENAEEQLSLSPVEGDILKNIIDTVYRKVLEEYEMEIMPDKDFLSNTKALAAQITKIILTEISYFQIPSDLVANLPLHLHSKLSQNVLVNRVHYDISKSRFRRQASTMYSTMLSHVHIEKIVTQLMSQINPSHSSVEYSDTSQSELNNTVIKLINEIMSIISKHAICIVKHGNEKQSMISEKDMQSMVDSIYADLSHSNLYQSLTKDKKGLSSIPVSKIASFIIKEIFNHHLESFLSGDKSILSTTVAQTCKKKPKTSTKQRELSIIVNSAVFLEEVITELLCKILQTFIQNSLDTETPERAIAKIMDIVTTLVKSIVLEFTTSEILVAEHLDESLRFSETYKEMVQRTVDSVYRNLFDECKSLTQLHKAVQNDTSCFGGKIYHFLLEEMYDYQVQSLVSGELMPSCYSSPQAANIIKNVLNVILKDTNALPSCITVLPCSVIENMIYKLLENIFPSDDTEDELKEKEAGPDDDDDEFMVAASKLTDEIMQEIYEHEIKFTNAEETAGIIYETTENFIDSVCKNILKKSEFQEEEEEEEVQKDAHKEGGSFLGKIAGSIIKEIMDHHLQLFLYGEDSPSSNLPHFGVASLIAKSMKEKAPSSLFSAAFLEDVIVDLAHKFCSFSTLTEDARKKDMPEAEIVSLAIKFANSLIRDFRKSGIKVLPHAEEIFSFPPIAKETIDEISNFVYDQFIGKFGADGIQKDGTGNIVIEMVSSLAQKAISTFKIQPLFSGDWCSTFFSFLDPENISQRVQLLPQNTSMKISDSLKQNQLALSKDTSITKDETQDPVLNSIATIMKSNIINLLSGPSEGDTDAKKEEESQVKPATPETTSPARSPLTSMKSQSTQVQHSATSPSTSMKGRGAQMKHSATSPHTSMRGRGAQMKHSATSPHTSMRGRGAQMKHSATSPHTTMKARGTQVQYLSDKCKRTETGKENLVLVNEQGQILEIFTHFAVAKTVENSPEKEGLRSDLKMQNKKIDVSESSVKREDKPKGKTKETMTEKTVLIPQQPVKEERRQSVAETDMEDESYSESEHVENVIENIYDNVLIVSSQEPLDFSRPMYSRSLLSDKALVILQDSAQLVKTKDLPPSVHKDIASKGKTRKETETRRREESETKKLKELKTKSSMTDPPKSSSESNIVPAKFLEDVIIELVNKLVFTSSPETEKCDKSTATSDQKPVELYDTAMRLVNSMMKEFSDAKIKVFRPKKEKEVLPKSVKESDLAAPPEIKETTIKKPPSSTDIKSKDKMSQTQKTPEQSFSDKLSSIEKTPSTEKTIVNKIVHSCVCSVLKECKSQESICESINSNGENLAKRLTSTVINEIFQHQLNLMFSDEIPASACVPLESKDVEKKVQTAVKTVSKECQTSSPYTIQLPYKFLEDVSSGLLAKVFSKLSNVKTKLTPENVLTQLDFIQMNLVKTIAAEISKNEDLIIQYVESLHPNDDEIVQLVVQTIYNNLLPQFGSQEILQKCLISGCKVLSKNIVDLVLREVTGNQLQNYFGGELTPYQCAEVDTVVENILTNVILTTPTQPPSPRKLSYNVIETIAVKFLSKLLSVFPKGSTERTKSQESEMQKITSKILNSIQEFFSKSKIEVVQPAKASEAVPSADKATIEKVVNSVYANLLKHSGSPNSVFEDLMGKSDVLSDIIGFSMVKEISNSEFQPQSEEELSSSELVLEAVKIMEKVVKIIDDLKSQEKTASIRDVVLDSRVLEEALALFLAKLVRKPGPASKDTNSLTKPELNKIASQLTKSVTAEISKSNISLVDSIPEEKSLDPENIEMISQVVESVYSDIIKQSGSKKELYDIKGTKKAFPKKVASLIVDGVSSVSSCRVSTGSSSAAALGDLDTNRIIEKAQKHAALMSSDSDKESEDVLEDELPVKIIPHVRNKPMKIDPNIVSEHLAVISMKTQPLETLKMDCIKRTGCSIAELRRASISGKGPSCTDVSESETRQKERRISLDRTGRLDVKPLEAVGRNSFQNVRRPDITRVELLKDINNKKDLIIRLVAHDIGQKDSDISLREDTVSDDEEVVLGEVVGDQCLRNVAGDYVEQVVKPPESQVASPKTATSSSSLKKFLALSKCCQPISGENIESIEVTGNQITEPNKTNVKRAVAELDMPYSKHLAEAPPSRDKLQYKKEEILPTEPTHYFIHRIMSTSSYNQEDLISGEAEEFIPDPKANALEESCQEPQEGNSNSVEFVTIYEESKNMASSARLSKEHVSEMPKSSISKQGSKVLAKVSSTLSKVFSRSSGSVPKSSSPPHQDKC", "length": 6940 }, "evidence": [ { "id": "F1MB15", "url": "https://omabrowser.org/oma/group/F1MB15/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A2ARZ3-1", "protein_name": "Fibrous sheath-interacting protein 2", "gene_name": "Fsip2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELYLSACSKTANVAANKAASSTVAEDSQQCVDGRHKTPIPGVGAAQLLDLPLGVKLPMIPGTDTVYFTTNISEKLFRPSYGFNLSDPYCRLLETQYKSLHDPHLRTYYKRKDILRRLKKGGYITSNNKIVCSLRELNKYRQYLTSLKLDFERNYLREQQLISKQLHKLQETSQLPHCSDVTRFQNWLLQDNTHSIKDQERLLRHRYLDMISKELEQLERTAEEQRLLRIDRDERRQREYTRKKLTLRRKIEEEWKTKEMMLLTKIGEDVKREQKIEEQRRKSREESDRKKQAMLEKKMAYHLQKMQDTGLKDDIGRNGFDYRGQNGTTFESSSKKRKKQFDDIKIVYPDGDQKAYRGTSGQVSATVNQSQSSSKDVTKVSASSVTYPAEVQNSSSEQKRSEVTKRLSDERGKNSTDDSARESIISTQLSPTRNAKLSQISLDHQKEEKEMKSTWNGGLSKKSSYAGEPGSPTDAPPQGIFSFPVNSNTQQNLQHCLKDKVTSEELNSIIQNIMTWVVATVTSILYPAITKYEERVQNNTYPVTDDSDLSSDSSSFCSTCSEGFTYRNYTAKTLPVDPCTFASDMPIKKPPTPLKPPSAHVERTVIDQTYQRQGQSVPSQVNYQKTSLDYQFPKIGSSKSDSHLLTSLETCTKKSKDATTETESLEISLLYDKKAKAMDQIKNLKNVFVNFKCHLKGETQLILESIFQEIMSDLSQAIPSLSSVTAEVFVDQTETEREELLSNVDICSVASEIVENMLEKLESAVEKRCVQMFSQEDLSVDIKPSLSTSGDYLSSVETKPSEETLSYTLEPMCDVADDMVHAILEKLMILASYKKNDVPPEDTTKHFQQTKTEPIHKVHQQTEQKKASFASDPANQIVKEEIQSLISSIFSQSSLVGYVEEAISTILGYVQTELNNERLIASEETVVLLQLLDDVLTQLHQQPVKAGVKKPRRPRVRNLSDPEEKYRVTGTRPFNNLKSKRPFPPVNVPGMVLYSEDDDEEIDNFVQSVLDSSFNDEKSSSQEQVPNYWPKKRDTYFESKRSNKLPTKSTFQNKVGSHDWGLKLELSLSSEDIVKTKHCLGQEPSIFSQDQKHQIQKASENIVKHILTDMLKDMSSDSSSHLGSQTGKGASAFISEKSQGLSDQEWMEQMFSVSEICAFAHEITDSVINILHKASMHIPNTIKNAFTSVHPTHVAPFDTAHTSKETPSKMPFKVWFDSEKKMKYLSSLNMEHEKTSQLRSGKCEPKRVNDITDKITNTIFKRLKLFVCPKLQIGNKSSLIEKSLHSQLSTYTMKIVNIILHAIQSELEINKTKPNLKETDHPKCHKNKGWFTDPNKVVESRVTSVNDDIMESPLLTCICEMISSTNEDKKNTSTYTDKTLSTSICESGNFHKQSILSNKQDKNSFCQLLAKPCLQHSLADEKDFKVSSKLEVLDQIGDTLHEMLGKLTGDHPDPQPSCSHQNTETIDKDPPTMSNTQLISKAILENVLAKLCDVDIDTSIVNSGPKTVPESLDIDNLSFASTMEEMAKCTNIISNIISKIMKDNKEVTKSKAKNDLPTSSKTEIPKEMCPQNLKNIASDILNMVFAKLEHFASGSVVNVGNLNDENKKEHTVDWECESNSSPADSHDKSLQSTLYSHAKKVSNGILKAIQTELNMNPPDCKTDKKRSPEETQILTNIVDLILDVVSSDMFAEPESENQSNENYGYRPTYGNFLPGGAESDSFLDDDTQNKELIRDATSFNEETRTLSTDQMGLERTLSKIEVKLKEPHRSPIVPIIRNILNEIFQSALINQLNVFSLSRAHFSGMPQNAPTSSTQTSAHFMDQMMGPLVSDTDVSIVVNDVVRTVFHKLYSAAMTERHVSENRGKTIILSANVSFRECTYGGNAPVSGLNENVCDLQSSWNVDKQIKINVVEDIVQAILGNLETFAASKVESLFCPQVKFTVPVTLPVMQEEGSLSQALSGKDSYSDNQLPCLVDHGNPEQMDSWYQMSLSKLNIYAKDVARKILQGIKHELDKEQESPLLTNNIVVSENIASQVVNKVLDIVSCKSKCDKKSSDKDHYSEQQVGIIEQLVNKREYRKILEFQIQDTIEGILCDIYENILYQNNLSFATPTLKYGIPAKHSEANFEQVVMGTNIIPKVSVPKADVILVSKDIVDIVLHNLTSLVVLAINAKDSAPARVAIYDIFPKPQFQQPLSITQRTEETPGHFSHSKNKNLGSPDVYQVPVNGKEDTKELAPDPCKENANRITQPIFNRLQSFATERINSLMTPAFQSKGNVFVSPQFEIGKDDNCIFHEPGQAESDVDVLKLTTRTVTSQELVEPIFTSCRENFGTTPHLSQTNLKDYAAFIASTILKLIKNDLDLEVQSMHTYSSHILFQKNMIVSEIVNNILKILPNKEPIKEFFLSSPENSSCSQLTISSEDLVGYKEKEKATALPQFTNDSLEENQVTVEKESQRDVLEEIFMRKGESKPREKTEILRTVEEVLKKLSQKIMEIIGHVAPFNESPHTVSKSKSKTAAATQKKFFQSRINNVSNDILENVLSEMHSVVVTSLYRNNKSKREGEMHDSSDSSSVKPSGSRETKPTRKRSSPLRLGVPQMHPHADNLNALVLENTILPYSPLQIGKYLVQIVLENLSNFVSLHLEEGYPPEGSYDDLYLLRLHNAKLSPKNSPRPGGKASLKMRSKINSLSKFKTKPHLGISSTKTKIKNKLSAGEKTPRESRSKTALGLPQTPQVEDTKTTLKTKLPVAELRLYATNIITDILQVILSSLERAAQHRAMFNTKVLASSQILEASKIVNAVLQELYATNNDNLASPINISSLSDRRLSKQNLGAGYPTEQPCFYLENVSSQLEQIFPKEGILKKMFDKWQTETSDTETEKSKLLTIAENILTEISIKAKDLEYSLSLLNLPPLEECENRLYDRFKGVSTRAEDTNAQINMFGREIVEMLFEKLQLCFLSQMPTQDSNGILTSRKEHGTSKSKHGVPTKPILGGIQTYNSKMADQVSMSPSNQIVHEIVERVLHMLESFVDLKFKHISKYEFSEIVKMPIDNLFQAQQRQLSKKMLPKLPFRKFGDESKPGTIISKDDGQNTLLQVHLFHSELLTYSVTAVSGMLRIIKNKLDKEISQMEPSPVSILKENITASEIIGTLIDQCSHFEESLIKNLPTKHWFQGTENVYIVNQVEFATPVKMPPSNTSDTPRTRRSSQGSVSGMGFSSEDDMKEKYSVTSNSSSHISSCVENTNKSLEPMGRSNSEAMPSGSRHKAHDHGQRKPNFTPFEQVTKTHNFLPQGSVLQKLFKKVNDSTEESLKQVLSFIETGKRENPRVFHYETTKSAEPNEIKTTAPPLKICLAAENIVNTVLSSYGFPHQPNTNESTETMKPFFMSRQIPLSEVCEGQKDTEKTLLKTWYSRKALIQEEESEGLEACQEDFSLLHKWKNKKPQMTTETVEETKTIVFADHELGPNEMHLVARHVTTSVITHLKNFKTGVSTEKFSHVSSLSKKIDDANQPLISIYSNSSVCQFCEHLSDAVICYLFLNISDGIKKCSREKAWEIQDAIIDKNVIIHSQLYKTRSISIGDLALSIFEVIVEVLANRNMINADKAHQASIKAKYMFCPGVTSSDFDDIFQDLLKEVIFVLSKILGINHFENNVRNKSYPTLKNNLPVFNKVNTIENQIGPRKLESSPPLTDQLAQKNKLNYLARRLNSLVGSLRSRESKEVVNEVFNIVLDLFLPDEIPDGDLSSGKLAKTFSSSNNQPSNRSLANNVGLSPKSIFLLNIVCEKLIRTLLEKCMGGTPFFEDSSLFREIPEECQHVKVLPSVQGGGFDYREAPMDCEQFQGDYMSELLENLADVDQDLLSSDCILNVISHSLVKSLMDKLSHGLQQAPFENKYRNYRTREMQPFITKAKRQELIEPEETKGHVGFMSYDNNFLTKSLNNTNANSFKKHTQFGKKHAGKSISLSFSDGKESRGINTACFHKLCQRGVNGGVFSATFLEEIISELFYNLSTSLWKKNPNITEAWLNEINTLLINNVVKKLNDAEITVLRYPEERLYFPSAHKGCIAKIVDSIYYDVLQQYEFTVTCGGNLPYDNTPVAKRISNSILLEVIDYQLPSCFKGKLRSNLYHTLNAEIILYKLHNSLKNFNSEPMTSKDYSTMLPHSFLEYVIRRVLAQLISLPIKSSSLEKKYLASSDFNEMSNCITNKVMSAISKHKIWLTIYDNQCLYTDKNLQKMVDSVYSNILQMSSSVDSIQKNIISRSPIMIDQIASFIIQEIIENHLQPFLCGERLPRPKTPLDEVSYMVKQVLSDVVESHKSQKPSPFGIYPDKLVGETVTRVLSKIFSPNTNINVELENVTQKIVSSVHKHLDKAKIPILCHKQPPFPFSNTDIVDELVTSVYKNVLKQHGLDPDIDESVNGEVFVENITKLITAAISDYLLHPLFSGDLPAASCSNSVTDHTVYDILGDINKSSKPNQTLPLYNTLLPYTFLEDMIRVLLSKFFPSAPKIDSYKAASKDKEGVNFNEIASNLISDIRRKISQHEIRFSKDEDKTKSFYSENDVQHLVDAVFMNILENYGSPESVEQNITKSNDVFIDQIAGFIIKYICEHHLQPFLERKQLSTSSYKYSDDDRQDLLYGSAYSSTFLEDVVSGVVSKIFHRVIGIVQVNSTINSENILFDKAENLIYWITEEFSKAQVTTIENAEERLSLSPVEGNILQKIIDTVYSKILEEHEMEIMPNKDFLNDTKALASQITEIILSEISYFQIPPDLVANLPLRLHSKLSQNVLVNKVHYDISKSRFRRQASTMYTTMLSHVHLEKIVTQLMSQINPSDSSVGHSDTYQSELSNTVVKLINEIMSIISKHAICIVKHGNEKQSMISEKEMQSMVDSIYADLSHSNLYQSLTKDKKGLSSIPVSKIANFIIKEIFNHHLESFLSGDKSILSASVAQTCKKKATTSTKQRELSFIVNSAVFLEEVITELLCKILQTFIQNSLSMETPERAIAEIMDIVTTLVKSIVFEFTSSEILVAEHLDESLWFSETYKEMVQKTVNSVYGNIFYEYKSLTQLHRAVQYDTSGFGGKMYHFLLEEMYDYQVQSLVSGELMPSCYASPQSANIIKNVLNVILKDTNALPSCITVLPCSLIENMIYKLLENIFPSDDTTNELKKEEKEEAGPDDVDEFMAAASKLTDEIIQEISEHEIRFANAEDTASMIYETTENFIDSVCNNILKNSEFQAEVQKDAHKKGGSFLSKIAGSIIKEIMDHYLQLFLYGEGSHSSKLPHFGGASVVAKSGKEKAPSSLFSAAFLEDVIVDLAHKFCSFLTLTDDARKKDLPEAEIVSLAIKFANSLIRDFRKSGIKVLPHAEEIFSFPPIAKETIDEISNFVYDQFIGKLGADGIQKDGTGNMVIEMVSSLAQKAISTFKIQPLFSGDWCSTFFSFLDAENISQRVQLLPKETSMQISGALKQNQLALSKITSIKKDDTQDPILNSIATIMKSNIINLLSGPSAGVTDAKKEDESKVKPATRETTSPPTSPPATMKSQGSQVQQLATSPPTSMKSQRIQVQQSVMSPPTTMKGKGAQVQQFATSPPTSMKSQGSQVQQSAMSPPTTMKSRGAQVQESVTSPFTTKESRGAQVQQSAMSPPPSMKDRGAQVQESSTSPPTTMKSRGAQVQHLSSKYKGNETGKENLVLVNEQGQILEIFTHFAVAKTVENSPEKEVFISDLKIQNEKKLDVSKSSVKTDDRPMSKDKETMTEKTVLIPQQPVKEERKQSVVKTDTEEEQYSENECVENVIENIYDNVFIVSSQEPLDFSRPIYSRSLTSDKALVILKDSAQLVPAKDLSSSGHRDIAAKEKASKETETKIRRDRSETKRSKEMKSKSSMTDHPKPSESKSKIVPAKFLEDVIAELVNKLVFTFISDKTTDTNEQKPGELYDTAMRLVNSMTKELSDAEIKVFRPEKEDEVQAAKEPAPTSPPEVKETVTKEPSPSTNIKNEDQMSDVQKTPEQSSPDKLPALEKIPSIEKSIVNKIVHSCVCNIFKECKSQESICENINSNGENLAKRLTSTVINEIFQHQLNLIFSDEVPASACVPLESKDVEQKVQNVVQTVSKECQTASPYTVQLPYKFLEDVTSGLLAKVFSKLSNVKTKLTPENVLTQLDFLQSNLVKTIAAEISKNEDLIIQYVESLHPNDDEVIQLVVQTIYNNLLPQFGSQEILQKCIISGCKLLSKTIVDLVLREVTGNQLQNYFGGELTPIQCAEVDNVVENILTNVVLTTPSQPSGPRKLSYNIIETIAVKFLSKLLSVFPKGHPERTKSQETEMRKITSKILHSIQEFISKSKIKVVQPVKESEAVPSADKAAIEKVVNSVYTNLLKHCGSPTSAFEDLMRKSDVISDIIGFSMVKEISNSEFQPQAEEELSSSELALEAVKIMEKVVKIIDELKSQEKPASITDVMLDSRVLEEALALFLAKLVKTPGPASKDTTSLTKPELNKIASQLTKSVTAEISKSNISLVESNHEEQSLDPENIEVISQVVESVYSNVVKQSGTENELSDIKGTKKAFPKKVASLIVDGVSSVPSCRVITESSYTAAHGDLDTNRIIEKAQKHAALMSSDSDKDSKKELEDEFPVRIVPHVRNKPLRIDPNIVSDHLAVISMKTQPLETLQMDCLKRTGCSIAELRRNSIRGIGPSSTDVSEMGTRQKERRISLDRTGRLDVKPLEAVGRNSFQNVRRPDITRVELLKDINNKTDLIIRLVAHDIGRKESDSSLSEGMVSDEEEVVLGEVVGDQCLRKISGGRVQQVKKSAESHVVSSKTATSTSNLKRFLALSKCCQPTSGENIESIEESGIQIMDPNKAYVKRAAAELDMPSCKSLAEETTSRDKLQYKEEEILASEPTHYFIHRIMSTSSYNQEDLISGEAEEFLPDAKANALEESCQEPQEGNSNSLEFVTIYKGSKHIAGSARLSKEHVSEMPRSSISKQGSRVLAKVSSTLSKVFSRSSGSIPKSSSPPHQDKR", "length": 6995 }, "evidence": [ { "id": "F1MB15", "url": "https://omabrowser.org/oma/group/F1MB15/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5CZC0-1", "protein_name": "Fibrous sheath-interacting protein 2", "gene_name": "FSIP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELYLGACSKPAKVAVTKTVASVLAADTQQCRDGVHKTHFAGVGPAQLLDLPLGVKLPVIPGSNAVFYTTNFGEKLFRPSYGFNLTDPYCRLLENQYKSLHDPHLKAYYKRKDILKRLKKGGYITSNNKVVCTLRELNKYRQYLTSLKLDFERNYIKEQRILAKQLHNIPENNQIPQHCDVAQVQNWLLKEGTESIKDQERLMRHRYLDMISRKLEQLERTAEEQRLFLMDREERRQREHTRRKLTLRRKIEEEWKTKEMLLLTRMAEDVKREERIEEQQHRNREESDRKKQDLLEKKMAYHLQKMQDTGFNGEDIGKNTFKYRGQDGTHASPKNKKKTSEDIMLVYPAGDQNTYKETHGHTANAAHQRQNSSNNFTKKNSASVVYQADVQDNGINQKRDGMVSKNSSIFDDRGGINISGQGSIISAQVSPTRNFSRVSQAFLDPSKEEKETNADWDGRPTKRSSYLCESGPQAHATDPGIFSSPVYTNMQQNLLQNCLQEKVTSEELNIIIQNVMTWVVATVTSILYPAITKYEKRLQNNTYPVSDDSILSSDSSSFCSTCSEDFTYRSYTSATTKTFQAEPCAFVVDTSVRRPTTPIKPPPAHVEKTVVGKTCHIKGQSIISKHKYNKTNLLYSYPKLRSCKSDSHLLASFETGTKKSKDATTETDSLGSSLHCDKTAKAMDEMKNLKNVFVNFKCYLKGETEVILESILREIMSDLTQAIPSLSSVTAEVFVEQCEREKEILLSNAHIPSVASEIVENMLEKLESAVEKKCVEMFSQDLSVDIKPSLAASDELLTSSNGKPLKNSMPHTLDPMCDIAEDMVHAILEKLMTLVSFKQNEFLHLKDTNKLSCQQHKTDPICMFLQRAGKNKSSLESDEASLIVNEEVQNLISNIFSQSSLVAYIEEAINAILGYIQTELNNERIIASEETVVLLQLLEDILFQLHQEPVNESFQKSRQPRISSPSDTKEKYRLTGTRLSNSPRSGRPFPPINVPGMVLYSDDENEEIDNIVKNVLDSTFKDEKVKSQEQIPNHWFTKGNTCFECKRNIKPPTKPGSRSKAAFHDWELKTEPPSTNHEDILKKKLSSNKDISTFSQDQKHQIEKASENIVTSILKEMLKDISSVPFGHLDSKTGSEASVLVSEKPQGLSHQEWIDQMFSVSEISTVAQEITDSVLNILHKASNYISNTTKSSISSSVHQISLHNSDTEHIVKEAPNKYPLKTWFDSEKKMKYLSLFDVDPEKPPWLKSGKSEPKPVDDINDKIIRTIFKRLKSFICPKLHMGFKSSLRSQLSKYTAKIVNIVLCAIQNELELHKENLNLREIDHTKSLTDKGFFANTDKKLESLVTSIDDDILASPLLTCIYDMLLSSENAHQRSISLSSRKPKSATDSVDVQSILPNRQDKKSFHKYLATPCTHHSVNGGNHIKENAKLQVLERIGETLHEMLSKLLGTHLHSQLSCSQQSREMTNKNQKMAAALQSNIQLISKAILDYILAKLCGVDMDTSFASCGLKAISESLDIDNPSFASIIEKMAKSTKIISSIVSRRVQEDNKEETKSKAKPVAPVSSKTPSTKEMHPNKLKAVASDILNMVFAKLEGFANGHLEILGAINDGNKKSNKIGWEYESTNISRDTHEASFLSALYMHAKKVSSAILKVIQTELNVTSSDLKTSVENPPPETQILKYVVKLILDAVSSDMFNEMESEGGGIETYRYRPTYGSLPGGAESDSFLEDDAYTAKKIIDERSPQREEVKTRSLKQWALEKTLNKIEVKLKEPHISPIAPIIRNILNEIFQSTLINQLNVLSLSHSNFNGMPHNVDEPTPQTSVQFMDKMMDPLLSEADITIVTDNIVRTVFHKLYSAAMTERNVRENRYKTITFSANVSSHEHTYKGKSSVTALDENPCTFQSRFSVADKETKVNLAEDIVQAILTNLETFATSKVKSLFYSQVNFTVPVALPIQQDHSTLSKALSAKDSYSDEQFSCCSVDHTKSGKTNLCQLSLSKLNTYALQVARRNLQGIKQELDKERENPFLTHDIGISESIASQIVNALLDIISRKGKCDKNSSDKEIDLDQQKGVIEKLLNETKYRKVLQLQIQDTIEGILCDIYEKTLFQNNLSFATPTLKCSIADKHSEENSEMFMEGANKIIPKLSVPKSDVILISNDIVNIVLHNLSSAATLVINAKNPTSARLPLTFCDTFPKIDCQQPLKGSKTERKTERFSYSRNQKSAYADDNQITVVEKEDTQKSATDSCEENANFITKTIFKRLESFATERIDSLITLAFQSKEKSFVIPELENCKQNDSIFYDSSQVESDVNVLKISATETILSQELTDFTFVGRREKLGSTIHLSQARLKTYADVIASAILKLIKNDLDLEIQKIYPYQNNILFQENIIVSEIVDSMLKMLDDKRSVKEICFNSKENSNFSQLALSNEILLGHKEKERSTKQSLFTKYPLEQNQMILENKRQIIVLEEIFMRNGESKNKEKGELLIAVEELLNKLYQRVREVTGHLPPLNETANFISNSKIKTSDTTQKNSFQSHINSVANDIVESVLGKMYLVVVTSLYENNKSRTEVEISDHNDSLLMKPLRFRETKQAGKISNSPRYAISQAYSYVDSQNISVMENTLLPYLPLQVKKDLIQMVLNKITNFVSLPLKVSPKDNPKPCFKAHLKTRSKITTLPKFTKKTHLGLSAAKAKSKTKLGPGEKTLKDSRSKTAIGLSHIMSAGDAKNLLDTKLPTSELKIYAKDIIINILETIVKEFGKVKQTKALPSDQIIAAGKIVNTVLQELYVTNNCNLAYPMKSSHLRLSQGNIGTGSLPKQQACFYLENVSSQLEHIFPREGIFKKLFDKWQTESNDKENEKCKLLMIAENVLTEISIKAKELEYSLSLLNLPPLENCESRFYNHFKGASTRAEDTKAQINMFGREIVEMLLEKLQLCFLSQIPTPDSEETLSNSKEHITAKSKYGFPNKHSLSSLPIYNTKTKDQISVGSSNQIVQEIVETVLNMLESFVDLQFKHISKYEFSEIVKMPIENLSSIQQKLLNKKMLPKLQPLKMFSDKSESNTINFKENIQNILLRVHSFHSQLLTYAVNIISDMLAVIKNKLDNEISQMEPSSISILKENIVASEIIGTLMDQCTYFNESLIQNLSRESLFQGAENAYTVNQVELATNMKMFTSKLKEGSLGINPSQVSKTGFVFCSDEDMKEKYRVSSDLPTSVRSSVEDTVKNSEPTKRPDSETMPSCSTRNKVQDHRPRESNFGSFDQTMKGNSYLPEGSFLQKLLRKASDSTEAALKQVLSFIEMGKGENLRVFHYENLKPVVEPNQIQTTISPLKICLAAENIVNTVLSSCGFPSQPHTNENREIMKPFFISKQSSLSEVSGGQKDNEKSLLRMQDKKINYIPEEENENLEASREDSSFLQKLKKKEYPKIETVKEVEAFTFADHEMGSNEVHLIARHVTTSVVTYLKNFETTVFSEEKMSVSTWSRKKYESKQFLRNIYDDSSIYQCCEHLTESVLYHLTSSISDGTKKGREKEKAWEIQEATFSKIISIHSQVFESRSISIGELALCISEIIIKILFNNKIIQADIAQKMVAIPTKYTYCPGIVSGGFDDLFQDLLVGVIHVLSKEIEVDYHFESNVRNKSFSMHRNNSVPLCNKINRQASPRDWQFSTQQIGQLFQKNKLSYLACKLNSLVGNLKTSESKEVVNKVFNIVSDLFSPDECLDTGMDSGKIQRTYFYSSNNEQPNSILTNNLQLSSKSVFLLNVVCEKLIRILLEECTSTAFPDKGSVSEETSAEECQLLKMLQSVEDGKSDYRKGGMDCECLQVDYMSDLLENVAEIDQDLLTSDSMLTIISHSLVKSLMDKLSHSIQQAPESLPFANKHLNYRTREIQSSFIKARKSELIELGQSKSSLELRSYDSNSLTVSLNNPSVVSSKIQAPFNKHCAVKSSSVSPFERQRTKEMDKVAIHNKLHQEGIYAGVYSATFLEGIISELFFNLSMSLWGKNKNITVSWLNEMNTLFVNNVVNEFNNAQVTVLRNAEERLCFPPVHTETVSKIVDSVYYDVLQQYELKVACGNNPVYDNASIAEQITNGILLEILDYKLPSCFKEHLIPHSYYPLKPEIILQKLQSNLTEFTSLPRSSSDYSTMLSHSFLEDVIRRLLSQLIPPPITCSSLGKKYLMSSDFNEMSTCIINKVMSAISKHKIWFTIYDNQYLYTGKNLQKMVDSVYCNILQMSDSLVSIQKSIVSRSPIMIDQIASFIIQEIIENHLQPFLSGEVLCHPRTPLDPVSTIVTQVLSEVIESHRPQKQSPLDIHLDSFVREIVARLLSKIFSPKHNTEIELKNMTQRIVNSINRHFNKAKIHILYDDKEQAFFSFNTDIVDELATSVYRNALKQHGLDLAVDKESEDSGIFVENITNLIVAAISDYLLHPLFSGDFSASTYSNSVAENIVQDILSNISKSTEPSQSVPLYNTLLPYTFLEDMIRVLLSKLFSSASSLVLNRDTQKDISRVNFNDIASNLVSDIRMKVSQHEIRFSKEEEETKFIYSEDDIQHLVDSVFANVVQTSGSQESAVQNITSSNDILIDRIAGFIIKHICQKHLQPFVSGKSLSSSDTYFDDERRQLFYTSVYSSTFLEDVISGVLRKIFHRVVGIVQTKSIRDSEDELFEKAEELIHLITGEFSKAQVSIIDNTEERLCLPPVERDVVKTIVDMVYSKVLQEYEMEVVPNKDFLNDTKTLAARITNIILAEIFDFQIHPDLIANLPFKSHSKLSANVLIQRVQYDISKSRFQRQASTMYTTMLSHSHLEKIVTQLTSQISPLNTSAEQSDTTKSDLSNTVIKLINEIMSIISKHEICIIKYGNKKQSMISAKDIQSMVDSIYADLSHSNIYQSITKDKKSISDIPVSKIASFIIKEIFNHHIQSFLSEDKTLLLAAVDQTYKLKAIDPKQRELSFIVNSSVFLEEVISELLCKILYAFSHNMLVTENPDRVKLKLTRIVTTLVNSIVLEFTTS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"length": 6907 }, "evidence": [ { "id": "F1MB15", "url": "https://omabrowser.org/oma/group/F1MB15/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "sperm end piece", "id": "GO:0097229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097229", "evidence": [ { "database": "UniProtKB", "id": "F1MB15", "url": "https://www.uniprot.org/uniprotkb/F1MB15" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "F1MB15", "url": "https://www.uniprot.org/uniprotkb/F1MB15" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "F1MB15", "url": "https://www.uniprot.org/uniprotkb/F1MB15" } ], "pmid": "" }, { "name": "sperm head-tail coupling apparatus", "id": "GO:0120212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120212", "evidence": [ { "database": "UniProtKB", "id": "F1MB15", "url": "https://www.uniprot.org/uniprotkb/F1MB15" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1204, "end_pos": 1206, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1254, "end_pos": 1256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1403, "end_pos": 1405, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1579, "end_pos": 1581, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1758, "end_pos": 1760, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1826, "end_pos": 1828, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1992, "end_pos": 1994, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2046, "end_pos": 2048, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2107, "end_pos": 2109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2197, "end_pos": 2199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2260, "end_pos": 2262, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2413, "end_pos": 2415, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2483, "end_pos": 2485, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2527, "end_pos": 2529, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2681, "end_pos": 2683, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2719, "end_pos": 2721, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3157, "end_pos": 3159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3174, "end_pos": 3176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3246, "end_pos": 3248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3311, "end_pos": 3313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3704, "end_pos": 3706, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3883, "end_pos": 3885, "annotation": "n_glycosylation_sequon" }, { "start_pos": 416, "end_pos": 418, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4230, "end_pos": 4232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4322, "end_pos": 4324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4342, "end_pos": 4344, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4617, "end_pos": 4619, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4642, "end_pos": 4644, "annotation": "n_glycosylation_sequon" }, { "start_pos": 504, "end_pos": 506, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5309, "end_pos": 5311, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5394, "end_pos": 5396, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5420, "end_pos": 5422, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5518, "end_pos": 5520, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5594, "end_pos": 5596, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5612, "end_pos": 5614, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6234, "end_pos": 6236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6736, "end_pos": 6738, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MB15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB15" }, { "id": "PF15783", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15783" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibrous sheath-interacting protein 2 C-terminal", "eco_id": "ECO_0000259", "start_pos": 3933, "end_pos": 4485, "start_aa": "Pro", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1204, "end_pos": 1206 }, { "start_pos": 1254, "end_pos": 1256 }, { "start_pos": 1403, "end_pos": 1405 }, { "start_pos": 1579, "end_pos": 1581 }, { "start_pos": 1758, "end_pos": 1760 }, { "start_pos": 1826, "end_pos": 1828 }, { "start_pos": 1992, "end_pos": 1994 }, { "start_pos": 2046, "end_pos": 2048 }, { "start_pos": 2107, "end_pos": 2109 }, { "start_pos": 2197, "end_pos": 2199 }, { "start_pos": 2260, "end_pos": 2262 }, { "start_pos": 2413, "end_pos": 2415 }, { "start_pos": 2483, "end_pos": 2485 }, { "start_pos": 2527, "end_pos": 2529 }, { "start_pos": 2681, "end_pos": 2683 }, { "start_pos": 2719, "end_pos": 2721 }, { "start_pos": 3157, "end_pos": 3159 }, { "start_pos": 3174, "end_pos": 3176 }, { 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"n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MB38-1", "uniprot_ac": "F1MB38", "uniprot_id": "F1MB38_BOVIN", "mass": { "chemical_mass": 120904.0, "monoisotopic_mass": 120904.0 }, "refseq": {}, "gene_names": [ { "name": "MAML2", "type": "recommended", "evidence": [ { "id": "F1MB38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB38" } ] } ], "protein_names": [ { "name": "Mastermind like transcriptional coactivator 2", "type": "synonym", "evidence": [ { "id": "F1MB38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB38/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MB38", "url": "https://www.uniprot.org/uniprotkb/F1MB38" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAML2", "url": "https://www.uniprot.org/uniprotkb/F1MB38", "locus": { "chromosome": "15", "start_pos": 14289608, "end_pos": 13888055, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037962", "url": "https://www.ensembl.org/id/ENSBTAG00000037962" } ] } } ], "crossref": [ { "id": "F1MB38", "url": "https://alphafold.ebi.ac.uk/entry/F1MB38", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037962", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037962", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR019082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046369", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046369", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "GMFNMTL", "url": "https://omabrowser.org/oma/group/GMFNMTL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MB38", "url": "https://www.orthodb.org/?gene=F1MB38", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15692", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15692", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15692:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15692:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09596", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09596", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-350054", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-350054", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8941856", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8941856", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MB38", "url": "https://www.uniprot.org/uniprotkb/F1MB38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB38-1", "url": "https://www.uniprot.org/uniprotkb/F1MB38-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGDTAPPQAPTGGLGGAPGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATASTATATAPPPAPAAPPTASQTAAPAAPAPPPDYHHHHQQHLRSSSSSGGSGGIDGEQQQQPPASTPGDQRNSALIALQGSLKRKQIVNLSPANSKRPNGFVDNSFLDIKRIRVGENLAAGPGGLPVNNGQSQMMSGTLPMSQVPLRKTAALPPPPTHSPGNGLFNMGLKEVKKEPGETLSCSKHVDGQVTQENIFSNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPLEKTVIKSEYSPGLTQGPSGSPQLRPSSAGPAFSMASSGLSASSPIPSVPQSQAQPPPATGAARALPSWQEVSHAQQLKQIAANRQQHVRMHQQQQQHQPTSWPALPSSAGPSPGPFGQEKIPSPSFGQQPFSPQSTPMPGVTGGSNQSKVMANYLFKASPSAQGGPLDVLLQPKPQDLSRSFLNNPHPAMEPRHGSTKPLFHFNSDQANQQMPSVLPSQSKPSLLHYTQQQPQQSSITVQPQQQQQQPQQQQQPQQQQQPQPQQQQQQQPQAQQPAAQPTQPLSNQPLLRAPLPLQQKILLQKMQNQPITGLGYQVSQQHRQDQHSVVGQNAGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLTRPPPDYKDQRRNVGNMQPTAQYSGGSSTVSLNSNQALANPVSTHTILTPNSSLMSTSHGTRMPSLPTAVQNIGIYGNLPCSQPSTYSVTSGMNQLTQPRNPNQLIANQNNPLMPRPPTLGPSNNNNNNVATFGAGSVGNSQQLRPNLTHSMASMPAQRTSNVMITSNTATPNWASQEATAKQQEALKSAGVRFPTGTTTAYAPNQSLQQAVGSQQFSQRAVAPSNQLTPAVQMRPMNQMSQTLNGQNMGPLRSLNLRPNQLSTQLLPTMNQAGTGLSQSRTVSQPPSLAAGGFPSPNQSSRAFQGTDHGNDLAFDFLNQQTDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS", "length": 1128, "header": "tr|F1MB38-1|F1MB38_BOVIN Isoform 1 of Mastermind like transcriptional coactivator 2 OS=Bos taurus OX=9913 GN=MAML2 PE=3 SV=3 CANONICAL=F1MB38-1" }, "isoforms": [ { "isoform_ac": "F1MB38-1", "url": "https://www.uniprot.org/uniprotkb/F1MB38/entry", "sequence": { "sequence": "MGDTAPPQAPTGGLGGAPGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATASTATATAPPPAPAAPPTASQTAAPAAPAPPPDYHHHHQQHLRSSSSSGGSGGIDGEQQQQPPASTPGDQRNSALIALQGSLKRKQIVNLSPANSKRPNGFVDNSFLDIKRIRVGENLAAGPGGLPVNNGQSQMMSGTLPMSQVPLRKTAALPPPPTHSPGNGLFNMGLKEVKKEPGETLSCSKHVDGQVTQENIFSNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPLEKTVIKSEYSPGLTQGPSGSPQLRPSSAGPAFSMASSGLSASSPIPSVPQSQAQPPPATGAARALPSWQEVSHAQQLKQIAANRQQHVRMHQQQQQHQPTSWPALPSSAGPSPGPFGQEKIPSPSFGQQPFSPQSTPMPGVTGGSNQSKVMANYLFKASPSAQGGPLDVLLQPKPQDLSRSFLNNPHPAMEPRHGSTKPLFHFNSDQANQQMPSVLPSQSKPSLLHYTQQQPQQSSITVQPQQQQQQPQQQQQPQQQQQPQPQQQQQQQPQAQQPAAQPTQPLSNQPLLRAPLPLQQKILLQKMQNQPITGLGYQVSQQHRQDQHSVVGQNAGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLTRPPPDYKDQRRNVGNMQPTAQYSGGSSTVSLNSNQALANPVSTHTILTPNSSLMSTSHGTRMPSLPTAVQNIGIYGNLPCSQPSTYSVTSGMNQLTQPRNPNQLIANQNNPLMPRPPTLGPSNNNNNNVATFGAGSVGNSQQLRPNLTHSMASMPAQRTSNVMITSNTATPNWASQEATAKQQEALKSAGVRFPTGTTTAYAPNQSLQQAVGSQQFSQRAVAPSNQLTPAVQMRPMNQMSQTLNGQNMGPLRSLNLRPNQLSTQLLPTMNQAGTGLSQSRTVSQPPSLAAGGFPSPNQSSRAFQGTDHGNDLAFDFLNQQTDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS", "length": 1128, "header": "tr|F1MB38-1|F1MB38_BOVIN Isoform 1 of Mastermind like transcriptional coactivator 2 OS=Bos taurus OX=9913 GN=MAML2 PE=3 SV=3 CANONICAL=F1MB38-1" }, "locus": { "chromosome": "15", "start_pos": 14287294, "end_pos": 13888254, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054262.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054262.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051992.3", "url": "https://www.ensembl.org/id/ENSBTAP00000051992.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 162, "start_aa": "Thr", "end_pos": 162, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr162", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-350054", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-350054", "resource": "Reactome", "description": "Notch-HLH transcription pathway" }, { "id": "R-BTA-8941856", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8941856", "resource": "Reactome", "description": "RUNX3 regulates NOTCH signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZYR8-1", "protein_name": "Mastermind like transcriptional coactivator 2", "gene_name": "MAML2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGDTAPPQAPTGGLGGAPGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATTTAATTTAPPPPPAAPPTASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGGGGIDGEQQPSASTPGDQRNSALIALQGSLKRKQIVNLPPANNKRPNGFVDNSFLDIKRIRVGENLAAGQGALQVNNGQSQIMSGTLPMSQAPLRKTATLPPHTHSPGNGMFNMGLKEVKKEPGETLSCSKHADGQVSQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLNQQSQRSTPRPSLPMEKTVIKSEYSPGLTQGPSGSPQLRPSSTGPAFSMANSGALSASSPIPSVPQSQAQPQTASGASRALPSWQEVSHAQQLKQIAANRQQHVRMQQHQQTSWPVLPSSAGPSPGPFGQEKIPSPSFGQQPFSPQSSPMPGVAGGSGGQSKVMANYLYKASPSAQGGHLDVLLQQKPQDLSRNFMNTPHTAVEPRLGNTKPLFHFNSDQANQQMPSVLPSQSKPSLLHYPQQPPQPQSSITAQQQQQQQQQQQQQQQQQPQPQQQPQPQQQPQPPAQPSQPLSSQPLLRSPLPLQQKILLQKMQNQPITGLGYQVSQQHRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLVDAEKIAPQDQINRHLTRPPPDYKDQRRSVGNMQPAAQYSGGSSTVSLNSNQPLANPVSTQPILTPNSSLMSTSHGTRMPSLSTAVQNIGMYGNLPCSQPGTYSVTSGMNQLTQQRNPNQLIASQNNPLMPRPPTLGPSNSNNNVATFGAGSVGNSQQLRPNLTHSMASLPAQRTSNVMITSNTTAPNWASQEATTKQQEALKSTGVRFPTGTPTAYTPNQPLQQAVGGQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRSLNLRPNQLSSQILPNLNQSGTGSRTGINQPPSLTPGSFPSPSQSSRAFQGTDHGSDLAFDFLNQQTDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS", "length": 1117 }, "evidence": [ { "id": "F1MB38", "url": "https://omabrowser.org/oma/group/F1MB38/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M1RIA2-1", "protein_name": "Mastermind-like protein 2", "gene_name": "maml2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGEAAPTQATPSGFAPMLGVGMGGSITPMATSRGSAVPQLHSAIVERLRARIELCRRHHSTCENRYERGLAENSDREHESTLQLLNIVHQGPGTRKTKGSRSASQHPSEFIRGNGEHKGHGASDAESKISSQIAQGLRRKIEAQSPGYTPKQNGLSCGASGSNFKRLRMESSSFRPGTCALAAGQTQRLVGDSTHGNILQRKDTFMTSHGIDVFNITLKDIKKEPIEVQTCGQATTDPSMLVFDFKDEVIGQIDPDLQDLFDELTKSVPSFNELEFEKMLKQDDDFGLDLGRPSSAGAAPPCVHLDKPIKTEYSSDLSHTTGGSQQLRPASAGPSFSMANTTLSTSPITSGLHGQVPSGGASRGHPAWPEISHAEQLKQMAANQLQPNSILHNHQQSQVRNWSSTLGVHQTLGSFPQETLPGNASLSQQRLNPQNTGQPKGLTNCFLKPNGFNQSHNVDAKILSNKPLLHFSPKAPPSTTGQQMPVMTVPPNKTTMQQQQAPSAGQGRHFQNCQLPMQPSSCLQTKPPSQRPLLNQHGAGISFKLTQQRQGISSAPRLPVNGRPVDLPSQVQQQRPPQKNPNQEQNLQRQLGQPQPNIADMEKLNTQDQFSRHLTRPPPDYKHPRNGVGAPQTSLYSGNVSDQSDIQSLSCQLANAPGAKMAASGERRFPLGQDPNSGPTGAQACANQQPGGLSRMGLQPNKTQFHGTNSQGGAFQLVRTSVSQDSLLGQRLSDSRMDAALNWATSAKQSGLDVKRLPNAVAPQSDVHFAPRSICPPNQVAPHSSLLPLNPANRSSAPRSSQPRIPPLPGVNQSSVEQQGCPSTFGGMNQSPVTYQNNRAGRLTFDFLPEDDNTVPGINADSDFIDSLLKSGSGNDDWMKDINLEEILGGHS", "length": 892 }, "evidence": [ { "id": "F1MB38", "url": "https://omabrowser.org/oma/group/F1MB38/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0Y1P9-1", "protein_name": "Mastermind like transcriptional coactivator 2", "gene_name": "MAML2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGDTAPPQAAGLAAGLLGGGPAAPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLHLVQQGQGARKAAKHPKAAAGTAGGGGGGAAAPAAAAAAAAPPDYHQHLLSNGGINGEQPAGEQRASALLALQGSLKRKLVVNLSPVNNKRPNGVSDSSFLDIKRIRVGDNISVGQGGHHVNNCQSQSMSGTMSVGQGSQRKTSNLANNTHASGNGIFNMTLKEVKKEPGETMSCSKHLDGQMSHENMFPNRYGEDSGEQMMDPELQELFNELTNISVPPMSDLELENMINATIKQDEPFNIDLGQQSQRGPVRPLQMDKMVIKSEYAPGMNQAPVGSPQMRPSSTGPAFTMATAAMSTSSPIPSVPQNQTQVAQVSSASSRPVPNWQEVSHAQQLKQIAANRQQHALIQQQQQQQNQTANWSTLSPSGPSPGPFVQEKIPSPSFRQQQFSPQSSAMLGVPVNGNQSKGMNNYVYKPTTPQSNPMDIIMQQKTQDLNRNFINSAQPPLEQHHGNTKPLFHFNSEQTNQQMPSVLGSQSKPALLHYTQQAQSSAPVQQPQPQQQQQPQPPSAQPLPNQSLQRPPNVPLAMQQKMMLQKIQQSQQISGLQYPVSQQHRQDQHSVVGQGAGPTPNSSSCSNPNTGSGYMNSSQQSMLNQQLMEKKQALQRQMMEQKQLLLQQQMLAEAEKITPQDQLNRHLTRPPPDYKDQRRNVVNMQQANQYPGGSPAVSMSSSMSLSNPISTHSIMPQSSSLMSTPAGTRMPSVPAARSMGCYGNLPCNQQSAYSVTSGMNQMQPHRNQNQVLPTQNNPMMTRQQTMTQSNNVAAFGTGSVVSSQQVRPSLNHGATGIPVQRPPNVMITATATAQNWAPQEAAVKQQDALKPTGVRFPTSTPYSNQSLQRNMGNQHFPQRALAPPNQLTAGVQMRPPLNQMHQTVNGQSTGSLRGLSVRPNQIRGQTVPTLSQPGTSMTPPSSLPPTSFTSTNQNSRAYQGGDHSSDLAFDFLNQQSDSIGPALNSDSDFIDSLLKTEPGNDDWMKDINLDEILGNHS", "length": 1059 }, "evidence": [ { "id": "F1MB38", "url": "https://omabrowser.org/oma/group/F1MB38/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1M3B2-1", "protein_name": "Mastermind-like transcriptional coactivator 2", "gene_name": "Maml2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTMQLLSLVQHGQGARKASKHAKATATTATTTAPPPPPTAPPVASQAASTAPPPPPDYHHHHQQHRLTSNDNGGINREQQPPASTPGDQRNSALLALQGSLKRKQIVNLSPANSKRPNGFPDSSFLDIKRIRVGENFSTGQGSLPVNNGQSHMMPGPLPMNQAPLRKTNALPPSAHSPGNNLFNMGLKEVKKEPGETLSCSKHMDDQLTQESVFTNRFGDDPGDQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFGIDLGQQSQRSTPRPSLPMDKIIIKSEYSPGLTPGSPQLRPPSAGPAFSLANSALSTSSPIPTVPQSQPQLQTVSGASRAPPSWQEVSHAQQLKQIAANRQQHVRMQQQQQQQQQQQQQQQQPPPSWPALQSSAGPSPGAFVQEKIPSPSFGQQPFSPQGSPMPGVTGSSNQSKAAGNYTYKASPSAQTGHLDVLLHQKPQDLSRGFINNPHPTLEPRHGNTKPLFHFNSDQANQQMPSQSKPSLLHYTQQQQPQLQPQSQQQQQQQQQQQQQQQQQQGSLAAQQQQQAQSSLAAQQQQQQQQQQQQQQQQQQQQQQQQPSQPTQALSSQPLLRSPLPLQQKIMLQKMQNQSIAGLGYQVTQQHRQDQHSVVGQSTGPSPSPNSCSNPNTGSGYMNSQQSLLNQQMMGKKQTLQRPTMEQKQQLLLQQQMLADAEKLSPQDQMNRHLTRPPPDYKDQRRNAGSLQPAAQYSGGPSSVSLNSNQALTNPVSTHTILTSNSSLMSTSHGMRMPLLSTVQNIGMYGNLPCNQPGTYSVTSAMNQLTQQRNTTQLITNQNNPLMPRPPPLGASTGNNAAAFGAGPAGSPQQLRPNLAHGLAGMTAQRSSTVMITASTTATNWASQEVTGKQQEALKPTGVRFPTSTPAYTPNQSLQPGVGSQPFSQRAVAPPSQLTPAVQMRPVNQMNQTLNGQTLGPLRGLNLRPNQLTTQNLSNMNPPGTGLNPPRTGANQPPSLTPNTFPSSNQSSRAFQGPDHGSDLAFDFLSQQSDSMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGSNS", "length": 1143 }, "evidence": [ { "id": "F1MB38", "url": "https://omabrowser.org/oma/group/F1MB38/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F6U238-1", "protein_name": "Mastermind like transcriptional coactivator 2", "gene_name": "Maml2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTMQLLSLVQHGQGARKASKHAKATVATATTTAPPPPPTAPPVASQAAATAPPPPPDYHHHHQQHRLTSNDNGGINREQPPASTPGDQRNSALLALQGSLKRKQIVNLSPANSKRPNGFVDSSFLDIKRIRVGENLSTGQGGLPVNNGQSQMMPGPLTMNQAPLRKTNALPPPAHSPGNNLFNMGLKEVKKEPGETLSCSKHMSDQMTQESVFTNRFGDDPGDQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFGIDLGQQSQRSTPRPSLPMEKIIIKSEYSPGLTQGTSGSPQLRPPSAGPAFSLANSALSTSSPIPTIPQSQPQLQTVSGANRALSSWQEVSHAQQLKQIAANRQQHARMQQQQQQQQQQPSPSWPALQSSAGPSPGAFVQEKIPSPSFSQQPFSPQGSPMPGVTGSNTQSKAAANYTYKASPSAQAGHLDVLLQQKPQELNRSFINNPHPALEPRHGNTKPLFHFNSDQANQQMPSLLPSQSKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQGSLAAQQQQQQPQPQSSLVAQQQQQQQQQQQQQQGSLTAQQQQQQQQQQQPSQPTHALSSQPLLRSPLQLQQKIMLQKMQTQSITGLGYQVTQQHRQDQHTVVGQNTGPSPSPNSCSNPNTGSGYMNSQQSLLNQQMMGKKQTLQRPTMEQKQQLLLQQQMLADAEKLSPQDQMNRHLTRPPPDYKDQRRNTGTLQPAAQYSGGSSTVSLNSNQALTNPVSTHTILTPNSSLMSTSHGMRMPLLSTVQNIGMYGNLPCNQPGTYNVTSTMNQLTQQRNTTQLITNQNNPLMSRPSPLGANNGNNVATFGAGSAGSSQQLRPNLAHSLSGMSAQRSSTVMITANTTATNWASQEVTGKQQEALKSTGVRFPTSTPAAYTPNQSLQPGVGSQPFSQRAVAPPSQLSPAVQMRPMNQMNQALNGQTLGSLRGLNLRPNQLAAQSLSNMNPSGTGLNHPRTGTNQPPSLTPNAFPSSNQSSRAFQGPDHGSDLAFDFLSQQSDSMCPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGSNS", "length": 1170 }, "evidence": [ { "id": "F1MB38", "url": "https://omabrowser.org/oma/group/F1MB38/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IZL2-1", "protein_name": "Mastermind-like protein 2", "gene_name": "MAML2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQVVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS", "length": 1156 }, "evidence": [ { "id": "F1MB38", "url": "https://omabrowser.org/oma/group/F1MB38/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "F1MB38", "url": "https://www.uniprot.org/uniprotkb/F1MB38" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MB38", "url": "https://www.uniprot.org/uniprotkb/F1MB38" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1MB38", "url": "https://www.uniprot.org/uniprotkb/F1MB38" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MB38", "url": "https://www.uniprot.org/uniprotkb/F1MB38" } ], "pmid": "" }, { "name": "positive regulation of transcription of Notch receptor target", "id": "GO:0007221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007221", "evidence": [ { "database": "UniProtKB", "id": "F1MB38", "url": "https://www.uniprot.org/uniprotkb/F1MB38" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1063, "end_pos": 1065, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1126, "end_pos": 1128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 334, "end_pos": 336, "annotation": "n_glycosylation_sequon" }, { "start_pos": 508, "end_pos": 510, "annotation": "n_glycosylation_sequon" }, { "start_pos": 816, "end_pos": 818, "annotation": "n_glycosylation_sequon" }, { "start_pos": 912, "end_pos": 914, "annotation": "n_glycosylation_sequon" }, { "start_pos": 970, "end_pos": 972, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MB38-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1128, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MB38-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MB38" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MB38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB38" }, { "id": "SM01275", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01275" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Neurogenic mastermind-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 30, "end_pos": 90, "start_aa": "Pro", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 162 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1063, "end_pos": 1065 }, { "start_pos": 1126, "end_pos": 1128 }, { "start_pos": 185, "end_pos": 187 }, { "start_pos": 318, "end_pos": 320 }, { "start_pos": 334, "end_pos": 336 }, { "start_pos": 508, "end_pos": 510 }, { "start_pos": 816, "end_pos": 818 }, { "start_pos": 912, "end_pos": 914 }, { "start_pos": 970, "end_pos": 972 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MB46-1", "uniprot_ac": "F1MB46", "uniprot_id": "F1MB46_BOVIN", "mass": { "chemical_mass": 59863.0, "monoisotopic_mass": 59863.0 }, "refseq": {}, "gene_names": [ { "name": "TBC1D10A", "type": "recommended", "evidence": [ { "id": "F1MB46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB46" } ] } ], "protein_names": [ { "name": "TBC1 domain family member 10A", "type": "synonym", "evidence": [ { "id": "F1MB46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB46/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MB46", "url": "https://www.uniprot.org/uniprotkb/F1MB46" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBC1D10A", "url": "https://www.uniprot.org/uniprotkb/F1MB46", "locus": { "chromosome": "17", "start_pos": 69307677, "end_pos": 69336680, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018086", "url": "https://www.ensembl.org/id/ENSBTAG00000018086" } ] } } ], "crossref": [ { "id": "F1MB46", "url": "https://alphafold.ebi.ac.uk/entry/F1MB46", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018086", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018086", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "AIQPQYM", "url": "https://omabrowser.org/oma/group/AIQPQYM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MB46", "url": "https://www.orthodb.org/?gene=F1MB46", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47219", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47219", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47219:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47219:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8854214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MB46", "url": "https://www.uniprot.org/uniprotkb/F1MB46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB46-1", "url": "https://www.uniprot.org/uniprotkb/F1MB46-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAARGRGVGGVGGGREAEAAEVAAEAEAAGAARMAKSFEENGPRAPAAQGSLSGTRESLAPGPDAAAADELSSLGSDSETNGFAERRIDKFGFIVGSQGAESPLEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSQQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKQALGSPEKVRGCQGQYETIERLRSLNPKVMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCPSPPRLHGAKAILEAEPGPRPSLQPSPSIRLPLDAPLSGSKGKSKASKQVQKEPREPARESGQRDQPPAASQAKAAAAAGDASPPQDMPVQDPAPQDPQGSAPRDSAHHRSRESLTSQESEDTYL", "length": 540, "header": "tr|F1MB46-1|F1MB46_BOVIN Isoform 1 of TBC1 domain family member 10A OS=Bos taurus OX=9913 GN=TBC1D10A PE=4 SV=3 CANONICAL=F1MB46-1" }, "isoforms": [ { "isoform_ac": "F1MB46-1", "url": "https://www.uniprot.org/uniprotkb/F1MB46/entry", "sequence": { "sequence": "MGAARGRGVGGVGGGREAEAAEVAAEAEAAGAARMAKSFEENGPRAPAAQGSLSGTRESLAPGPDAAAADELSSLGSDSETNGFAERRIDKFGFIVGSQGAESPLEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSQQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKQALGSPEKVRGCQGQYETIERLRSLNPKVMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCPSPPRLHGAKAILEAEPGPRPSLQPSPSIRLPLDAPLSGSKGKSKASKQVQKEPREPARESGQRDQPPAASQAKAAAAAGDASPPQDMPVQDPAPQDPQGSAPRDSAHHRSRESLTSQESEDTYL", "length": 540, "header": "tr|F1MB46-1|F1MB46_BOVIN Isoform 1 of TBC1 domain family member 10A OS=Bos taurus OX=9913 GN=TBC1D10A PE=4 SV=3 CANONICAL=F1MB46-1" }, "locus": { "chromosome": "17", "start_pos": 69336481, "end_pos": 69308041, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055485.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055485.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049672.3", "url": "https://www.ensembl.org/id/ENSBTAP00000049672.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8854214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854214", "resource": "Reactome", "description": "TBC/RABGAPs" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0X4R4-1", "protein_name": "TBC1 domain family member 10A", "gene_name": "TBC1D10A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGGTSWGTAGMGLPRAVAPGRPNGDKLTTQRGCASTETLAGSPQRVIHQSSALQESILLLLGSLGPSGLWDDGYGACSHSDVPLPRRLEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGSKVKLEQNVGKFDELDVLPGEPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGQILFSLLHKVSPVAYKHLSKQKIDPILYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHTLGSSDKLKSCQGQYETMERLRALSPKIMQETFLVQEVIELPVTERQIEREHLIQLKKWRETHGELQCKSPPRLHGAKAISEAEPPTRKALEPVPSIIVPPGPAPVPKARKSKEKNREKASGSPANGPGAEGNGAPGATRELLHPQSSPHHQSKESLCSRESEDTYL", "length": 497 }, "evidence": [ { "id": "F1MB46", "url": "https://omabrowser.org/oma/group/F1MB46/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RFD6-1", "protein_name": "TBC1 domain family member 10A", "gene_name": "TBC1D10A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGAARGRGVGGSRAAEAAEVAEVAAEAEAAGAAGMAKSSGENGPRASAARGSLSGTRESLAPGPDAATADELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSQQKIDPLLYMTEWFMCAFARTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKLKACQGQYETIERLRSLSPKIMEEAFLVQEVVELSVTERQIEREHLIQLRRWQETRGELQCHSSPRLHGAKAILEAEPGPWPTLQPSPSIRLPPDAPLPGSKGKSKPSKQVQKEQKEQRKQAKASGQPDKPTTTSQAKVVAAAGDACPPQDVPSKDPGHQDPAPQDSAPQDTAHHRSQESLTSQESEDTYL", "length": 545 }, "evidence": [ { "id": "F1MB46", "url": "https://omabrowser.org/oma/group/F1MB46/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P58802-1", "protein_name": "TBC1 domain family member 10A", "gene_name": "Tbc1d10a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKSSRENGPREPAAGGSLSGTRESLAQGPDAATADELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQVCEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFARTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKLKACQGQYETIEQLRSLSPKIMQEAFLVQEVIELPVTERQIEREHLIQLRRWQETRGELECRSLPRMHGAKAILDAEPGPRPALQPSPSIRLPPDAALLSSKAKPHKQAQKEQKRTKTSAQLDKSPGLSQATVVTAAGDACPPQGVSPKDPVPQDPTPQNLACHHSQESLTSQESEDTYL", "length": 500 }, "evidence": [ { "id": "F1MB46", "url": "https://omabrowser.org/oma/group/F1MB46/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BXI6-1", "protein_name": "TBC1 domain family member 10A", "gene_name": "TBC1D10A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPGSKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL", "length": 508 }, "evidence": [ { "id": "F1MB46", "url": "https://omabrowser.org/oma/group/F1MB46/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "F1MB46", "url": "https://www.uniprot.org/uniprotkb/F1MB46" } ], "pmid": "" }, { "name": "PDZ domain binding", "id": "GO:0030165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030165", "evidence": [ { "database": "UniProtKB", "id": "F1MB46", "url": "https://www.uniprot.org/uniprotkb/F1MB46" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MB46", "url": "https://www.uniprot.org/uniprotkb/F1MB46" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MB46", "url": "https://www.uniprot.org/uniprotkb/F1MB46" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "F1MB46", "url": "https://www.uniprot.org/uniprotkb/F1MB46" } ], "pmid": "" }, { "name": "positive regulation of proteolysis", "id": "GO:0045862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045862", "evidence": [ { "database": "UniProtKB", "id": "F1MB46", "url": "https://www.uniprot.org/uniprotkb/F1MB46" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MB46-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 540, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MB46-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MB46" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MB46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB46" }, { "id": "PS50086", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50086" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rab-GAP TBC", "eco_id": "ECO_0000259", "start_pos": 145, "end_pos": 333, "start_aa": "Gly", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MB53-1", "uniprot_ac": "F1MB53", "uniprot_id": "F1MB53_BOVIN", "mass": { "chemical_mass": 36975.0, "monoisotopic_mass": 36975.0 }, "refseq": { "ac": "NP_001178987", "name": "annexin A10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178987" }, "gene_names": [ { "name": "ANXA10", "type": "recommended", "evidence": [ { "id": "F1MB53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB53" } ] }, { "name": "ANXA10", "type": "synonym", "evidence": [ { "id": "NP_001178987", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178987" } ] } ], "protein_names": [ { "name": "Annexin A10", "type": "synonym", "evidence": [ { "id": "F1MB53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB53/entry#names_and_taxonomy" } ] }, { "name": "annexin A10", "type": "synonym", "evidence": [ { "id": "NP_001178987", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178987" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MB53", "url": "https://www.uniprot.org/uniprotkb/F1MB53" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANXA10", "url": "https://www.uniprot.org/uniprotkb/F1MB53", "locus": { "chromosome": "8", "start_pos": 571472, "end_pos": 495871, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004944", "url": "https://www.ensembl.org/id/ENSBTAG00000004944" } ] } } ], "crossref": [ { "id": "F1MB53", "url": "https://alphafold.ebi.ac.uk/entry/F1MB53", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004944", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004944", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505322", "url": "https://www.ncbi.nlm.nih.gov/gene/505322", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001464", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001464", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008156", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008156", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:505322", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505322", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KEIHDSW", "url": "https://omabrowser.org/oma/group/KEIHDSW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MB53", "url": "https://www.orthodb.org/?gene=F1MB53", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10502", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10502", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10502:SF100", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10502:SF100", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00191", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00191", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178987", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MB53", "url": "https://www.uniprot.org/uniprotkb/F1MB53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB53-1", "url": "https://www.uniprot.org/uniprotkb/F1MB53-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFCGDYVQGTIFPAPNFNPVLDAELLGGALQGFGCDKDLLIDILTQRCNTQRLLIAEAYLGAFSRDLVGDLKEKLSNHFKDVMVGLMYPPPSYDAHELWHAMKGAGTDENCLIDILASRTNGEIFQMREAYYLQYSRDLQEDIYSETSGHFRDMLVSLVQGTREEGYTDPATATQDAMVLWEACQQRTGEHKTLLQLMLCNKSYQQLCLVFQEFQNISGQDIVDAINECYDGYFRELLVATVLCIRDKPAYFAYRLYSAIHDFGFHNKTVIRILIARSEIDLMTIRKRYKERYGKSLFHDIKNFASGHYEKALLAICAGDADDY", "length": 324, "header": "tr|F1MB53-1|F1MB53_BOVIN Isoform 1 of Annexin A10 OS=Bos taurus OX=9913 GN=ANXA10 PE=3 SV=2 CANONICAL=F1MB53-1" }, "isoforms": [ { "isoform_ac": "F1MB53-1", "url": "https://www.uniprot.org/uniprotkb/F1MB53/entry", "sequence": { "sequence": "MFCGDYVQGTIFPAPNFNPVLDAELLGGALQGFGCDKDLLIDILTQRCNTQRLLIAEAYLGAFSRDLVGDLKEKLSNHFKDVMVGLMYPPPSYDAHELWHAMKGAGTDENCLIDILASRTNGEIFQMREAYYLQYSRDLQEDIYSETSGHFRDMLVSLVQGTREEGYTDPATATQDAMVLWEACQQRTGEHKTLLQLMLCNKSYQQLCLVFQEFQNISGQDIVDAINECYDGYFRELLVATVLCIRDKPAYFAYRLYSAIHDFGFHNKTVIRILIARSEIDLMTIRKRYKERYGKSLFHDIKNFASGHYEKALLAICAGDADDY", "length": 324, "header": "tr|F1MB53-1|F1MB53_BOVIN Isoform 1 of Annexin A10 OS=Bos taurus OX=9913 GN=ANXA10 PE=3 SV=2 CANONICAL=F1MB53-1" }, "locus": { "chromosome": "8", "start_pos": 571200, "end_pos": 496037, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006504.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006504.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006504.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006504.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505322", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505322", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZXN8-1", "protein_name": "Annexin A10", "gene_name": "Anxa10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFCGEYVQGTIFPAPNFNPMMDAQVIDGALQGFECNKDLLIDILTQRSNAQRQMIAGTYQSMYGRDLIADLKEQLSSHFKEVMVGLMYPPPSYDAHELWHAMKGAGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNLVQGNREEGYTDPAMAAQDAMVLWEACQQKTGEHKTMLQMILCNKSYPQLWLIFQEFQTISGQDLVDTISDCYDGYFQELLIAIVRCVQDKPSYFAYKLYRAIHDFGFHNKTVIRILIARSEIDLMTIRKRYKERFGKSLFHDIKSFASGHYKKALLAICAGDVEDY", "length": 324 }, "evidence": [ { "id": "F1MB53", "url": "https://omabrowser.org/oma/group/F1MB53/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LFK6-1", "protein_name": "Annexin A10", "gene_name": "ANXA10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFCGDYVQGTIVPAPNFNPMLDAQMLGGALQGFGCDKDLLIDILTQRCNAQRLVIAEAYQGAFCRDLVSDLKEKLSDHFKDVMVGLMYPPPSYDAHELWHAMKGAGTDENCLIDILASRTNGEIFQMREAYYLQYSRDLQEDIYAETSGHFRDMLVNLVQGTREEGYTDPAMAAQDAMVLWEACQQRTGEHKTLLQMILCNKSYQQLWLVFQEFQNISGQDIVDAINECYDGYFQELLVAVVLCVRDKPAYFAYRLYSAIHDFGFHNRTVIRILIARSEIDLMTIRKRYKERYGKSLFHDIRNFASGHYEKALLAICAGDTDEY", "length": 324 }, "evidence": [ { "id": "F1MB53", "url": "https://omabrowser.org/oma/group/F1MB53/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9QZ10-1", "protein_name": "Annexin A10", "gene_name": "Anxa10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFCGEYVQGTIFPAPNFNPMMDAQMLGGALQGFDCNKDMLIDILTQRSNAQRQMIAGTYQSMYGRDLISVLKEQLSSHFKEVMVGLMYPPPSYDAHELWHAMKGPGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNLVQANREEGYSDPAMAAQDAMVLWEACQQKTGEHKTMMQMILCNKSYPQLWLVFQEFQNISGQDLVDAINDCYDGYFQELLVAIVRCIQDKPSYFAYKLYRAIHDFGFHNKTVIRILIARSEIDLMTIRKRYKERFGKSLFHDIKNFASGHYEKALLAICAGDVEDY", "length": 324 }, "evidence": [ { "id": "F1MB53", "url": "https://omabrowser.org/oma/group/F1MB53/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UJ72-1", "protein_name": "Annexin A10", "gene_name": "ANXA10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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[provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377182" }, "gene_names": [ { "name": "OR52I1", "type": "recommended", "evidence": [ { "id": "F1MB62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB62" } ] }, { "name": "OR52I1", "type": "synonym", "evidence": [ { "id": "NP_001377182", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377182" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1MB62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB62/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 52 subfamily I member 1", "type": "synonym", "evidence": [ { "id": "NP_001377182", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377182" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MB62", "url": "https://www.uniprot.org/uniprotkb/F1MB62#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. 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[provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377182" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MB62", "url": "https://www.uniprot.org/uniprotkb/F1MB62#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MB62", "url": "https://www.uniprot.org/uniprotkb/F1MB62" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR52I1", "url": "https://www.uniprot.org/uniprotkb/F1MB62", "locus": { "chromosome": "15", "start_pos": 50443744, "end_pos": 50444718, "strand": "+", "evidence": 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"bta:618050", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618050", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FYGSHMV", "url": "https://omabrowser.org/oma/group/FYGSHMV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MB62", "url": "https://www.orthodb.org/?gene=F1MB62", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF177", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF177", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377182", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MB62", "url": "https://www.uniprot.org/uniprotkb/F1MB62", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB62-1", "url": "https://www.uniprot.org/uniprotkb/F1MB62-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGLPYNHTTEAPATFILVGIPGLQSSHLWLAVSLSIMYTTALLANTLIVTIIWMDSTLQEPMYCFLCVLAAVDMVMASSVVPNMVSIFSSGDNTISFNACFTQMYFVHAATAVESGLLLAMAFDRYVAICKPLHYKRILTPRVMLGISVTITIRATVFMTPLSWMVSHLPFCGSNMVLHSYCEHIAVAKLACADPRPSSLYSLIGTSIIVGSDVAFIAASYILILQAVFSLSSKNAQLKALSTCGSHVGVMALYYLPGMASIYVPWLGKDIMPVHIQVLLADLYLIIPPTLNPIIYGLRIKQIRNRTWSLLMHCLFKHSNLGS", "length": 324, "header": "tr|F1MB62-1|F1MB62_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR52I1 PE=3 SV=2 CANONICAL=F1MB62-1" }, "isoforms": [ { "isoform_ac": "F1MB62-1", "url": "https://www.uniprot.org/uniprotkb/F1MB62/entry", "sequence": { "sequence": "MLGLPYNHTTEAPATFILVGIPGLQSSHLWLAVSLSIMYTTALLANTLIVTIIWMDSTLQEPMYCFLCVLAAVDMVMASSVVPNMVSIFSSGDNTISFNACFTQMYFVHAATAVESGLLLAMAFDRYVAICKPLHYKRILTPRVMLGISVTITIRATVFMTPLSWMVSHLPFCGSNMVLHSYCEHIAVAKLACADPRPSSLYSLIGTSIIVGSDVAFIAASYILILQAVFSLSSKNAQLKALSTCGSHVGVMALYYLPGMASIYVPWLGKDIMPVHIQVLLADLYLIIPPTLNPIIYGLRIKQIRNRTWSLLMHCLFKHSNLGS", "length": 324, "header": "tr|F1MB62-1|F1MB62_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR52I1 PE=3 SV=2 CANONICAL=F1MB62-1" }, "locus": { "chromosome": "15", "start_pos": 50444718, "end_pos": 50443747, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065182.2", "url": "https://www.ensembl.org/id/ENSBTAT00000065182.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053973.2", "url": "https://www.ensembl.org/id/ENSBTAP00000053973.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618050", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618050", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8NGK6-1", "protein_name": "Olfactory receptor 52I1", "gene_name": "OR52I1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLGPAYNHTMETPASFLLVGIPGLQSSHLWLAISLSAMYITALLGNTLIVTAIWMDSTRHEPMYCFLCVLAAVDIVMASSVVPKMVSIFCSGDSSISFSACFTQMFFVHLATAVETGLLLTMAFDRYVAICKPLHYKRILTPQVMLGMSMAVTIRAVTFMTPLSWMMNHLPFCGSNVVVHSYCKHIALARLACADPVPSSLYSLIGSSLMVGSDVAFIAASYILILRAVFDLSSKTAQLKALSTCGSHVGVMALYYLPGMASIYAAWLGQDIVPLHTQVLLADLYVIIPATLNPIIYGMRTKQLLEGIWSYLMHFLFDHSNLGS", "length": 324 }, "evidence": [ { "id": "F1MB62", "url": "https://omabrowser.org/oma/group/F1MB62/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MB62", "url": "https://www.uniprot.org/uniprotkb/F1MB62" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1MB62", "url": "https://www.uniprot.org/uniprotkb/F1MB62" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MB62", "url": "https://www.uniprot.org/uniprotkb/F1MB62" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MB62-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 324, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MB62-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MB62" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MB62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB62" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 297, "start_aa": "Ala", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 306, "end_pos": 308 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MB71-1", "uniprot_ac": "F1MB71", "uniprot_id": "F1MB71_BOVIN", "mass": { "chemical_mass": 150757.0, "monoisotopic_mass": 150757.0 }, "refseq": { "ac": "XP_024841137", "name": "caskin-1 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841137" }, "gene_names": [ { "name": "CASKIN1", "type": "recommended", "evidence": [ { "id": "F1MB71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB71" } ] }, { "name": "CASKIN1", "type": "synonym", "evidence": [ { "id": "XP_024841137", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841137" } ] } ], "protein_names": [ { "name": "Caskin-1", "type": "recommended", "evidence": [ { "id": "F1MB71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB71/entry#names_and_taxonomy" } ] }, { "name": "CASK-interacting protein 1", "type": "synonym", "evidence": [ { "id": "F1MB71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB71/entry#names_and_taxonomy" } ] }, { "name": "caskin-1 isoform X4", "type": "synonym", "evidence": [ { "id": "XP_024841137", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841137" } ] } ], "function": [ { "annotation": "May link the scaffolding protein CASK to downstream intracellular effectors.", "evidence": [ { "database": "UniProtKB", "id": "F1MB71", "url": "https://www.uniprot.org/uniprotkb/F1MB71#function" }, { "database": "UniProtKB", "id": "ARBA00055074", "url": "https://www.uniprot.org/uniprotkb/ARBA00055074#function" } ] }, { "annotation": "Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.", "evidence": [ { "database": "UniProtKB", "id": "F1MB71", "url": "https://www.uniprot.org/uniprotkb/F1MB71#function" }, { "database": "UniProtKB", "id": "ARBA00025297", "url": "https://www.uniprot.org/uniprotkb/ARBA00025297#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MB71", "url": "https://www.uniprot.org/uniprotkb/F1MB71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CASKIN1", "url": "https://www.uniprot.org/uniprotkb/F1MB71", "locus": { "chromosome": "25", "start_pos": 1711154, "end_pos": 1728927, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037945", "url": "https://www.ensembl.org/id/ENSBTAG00000037945" } ] } } ], "crossref": [ { "id": "ENSBTAG00000037945", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037945", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09497", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09497", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09498", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09498", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12062", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12062", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614560", "url": "https://www.ncbi.nlm.nih.gov/gene/614560", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032232", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032232", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035497", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035497", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035498", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035498", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614560", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614560", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MB71", "url": "https://www.orthodb.org/?gene=F1MB71", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24174", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24174", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24174:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24174:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13637", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13637", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16600", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16600", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16632", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16632", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16907", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16907", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024841137", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841137", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MB71", "url": "https://www.uniprot.org/uniprotkb/F1MB71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB71-1", "url": "https://www.uniprot.org/uniprotkb/F1MB71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MB88-1", "uniprot_ac": "F1MB88", "uniprot_id": "F1MB88_BOVIN", "mass": { "chemical_mass": 50940.0, "monoisotopic_mass": 50940.0 }, "refseq": { "ac": "XP_005224349", "name": "zinc finger and BTB domain-containing protein 14", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224349" }, "gene_names": [ { "name": "ZBTB14", "type": "recommended", "evidence": [ { "id": "F1MB88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB88" } ] }, { "name": "ZBTB14", "type": "synonym", "evidence": [ { "id": "XP_005224349", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224349" } ] } ], "protein_names": [ { "name": "Zinc finger and BTB domain-containing protein 14", "type": "recommended", "evidence": [ { "id": "F1MB88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB88/entry#names_and_taxonomy" } ] }, { "name": "zinc finger and BTB domain-containing protein 14", "type": "synonym", "evidence": [ { "id": "XP_005224349", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224349" } ] } ], "function": [ { "annotation": "Transcriptional activator of the dopamine transporter (DAT), binding its promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.", "evidence": [ { "database": "UniProtKB", "id": "F1MB88", "url": "https://www.uniprot.org/uniprotkb/F1MB88#function" }, { "database": "UniProtKB", "id": "ARBA00094111", "url": "https://www.uniprot.org/uniprotkb/ARBA00094111#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MB88", "url": "https://www.uniprot.org/uniprotkb/F1MB88" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZBTB14", "url": "https://www.uniprot.org/uniprotkb/F1MB88", "locus": { "chromosome": "24", "start_pos": 38818317, "end_pos": 38822312, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038970", "url": "https://www.ensembl.org/id/ENSBTAG00000038970" } ] } } ], "crossref": [ { "id": "F1MB88", "url": "https://alphafold.ebi.ac.uk/entry/F1MB88", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038970", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038970", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18204", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18204", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "101904037", "url": "https://www.ncbi.nlm.nih.gov/gene/101904037", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050457", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050457", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:101904037", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101904037", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CIGCDYK", "url": "https://omabrowser.org/oma/group/CIGCDYK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MB88", "url": "https://www.orthodb.org/?gene=F1MB88", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46105:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46105:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005224349", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224349", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MB88", "url": "https://www.uniprot.org/uniprotkb/F1MB88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MB88-1", "url": "https://www.uniprot.org/uniprotkb/F1MB88-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDENNGQSKSKYCLKINRPIGDAADPQDDDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALAFNDGMSEVKDEQTPGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHSERKQVTPSAMQSETEQLQAAAMAAEAEQQLETIACS", "length": 449, "header": "tr|F1MB88-1|F1MB88_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 14 OS=Bos taurus OX=9913 GN=ZBTB14 PE=3 SV=3 CANONICAL=F1MB88-1" }, "isoforms": [ { "isoform_ac": "F1MB88-1", "url": "https://www.uniprot.org/uniprotkb/F1MB88/entry", "sequence": { "sequence": "MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDENNGQSKSKYCLKINRPIGDAADPQDDDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALAFNDGMSEVKDEQTPGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHSERKQVTPSAMQSETEQLQAAAMAAEAEQQLETIACS", "length": 449, "header": "tr|F1MB88-1|F1MB88_BOVIN Isoform 1 of Zinc finger and BTB domain-containing protein 14 OS=Bos taurus OX=9913 GN=ZBTB14 PE=3 SV=3 CANONICAL=F1MB88-1" }, "locus": { "chromosome": "24", "start_pos": 38822047, "end_pos": 38819321, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053525.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053525.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051951.3", "url": "https://www.ensembl.org/id/ENSBTAP00000051951.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:101904037", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:101904037", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AKH6-1", "protein_name": "Zinc finger and BTB domain-containing protein 14", "gene_name": "ZBTB14", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDENNGQSKSKYCLKINRPIGDTADAQDDDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALTFNDGMSEVKDEQTPGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHSERKQVTPSAIQSETEQLQAAAMAAEAEQQLETIACS", "length": 449 }, "evidence": [ { "id": "F1MB88", "url": "https://omabrowser.org/oma/group/F1MB88/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XC43-1", "protein_name": "Zinc finger and BTB domain containing 14", "gene_name": "ZBTB14", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEFFISMSETIKYNDDDHKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPEENTQSKSKYCLKINRPIGEPNDTQDDEVEEIGDHDDSPSDVTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETTESKDLGSQTPQALTFNDGISEVKDEQTPGWTTAAGDMKFEYLLYGHREHIVCQACGKTFSDEARLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRLAAANLTVNSHSQQNKSSLDCSLLCVVNKQRHKNSDNVIQRDIKPLFKICKYSTVVNTAFEVGMGKNALFLAHDWTTLIICDTYSI", "length": 490 }, "evidence": [ { "id": "F1MB88", "url": "https://omabrowser.org/oma/group/F1MB88/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1LMU5-1", "protein_name": "Zinc finger and BTB domain-containing protein 14", "gene_name": "Zbtb14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDESNGQSKSKYCLKLNRPIGDAADAQDDDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALTFNDGMSEVKDEQTPGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHSERKQVTPSAIQSETEQLQAAAMAAEAEQQLETIACS", "length": 449 }, "evidence": [ { "id": "F1MB88", "url": "https://omabrowser.org/oma/group/F1MB88/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HT51-1", "protein_name": "Zinc finger and BTB domain-containing protein 14", "gene_name": "Zbtb14", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDESNGQSKSKYCLKLNRPMGDAADAQDDDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALTFNDGMGEVKDEQTPGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHNDRKQVTPSAIQSETEQLQAAAMAAEAEQQLETIACS", "length": 449 }, "evidence": [ { "id": "F1MB88", "url": "https://omabrowser.org/oma/group/F1MB88/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O43829-1", "protein_name": "Zinc finger and BTB domain-containing protein 14", "gene_name": "ZBTB14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDENNGQSKSKYCLKINRPIGDAADTQDDDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALTFNDGMSEVKDEQTPGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHSERKQVTPSAIQSETEQLQAAAMAAEAEQQLETIACS", "length": 449 }, "evidence": [ { "id": "F1MB88", "url": "https://omabrowser.org/oma/group/F1MB88/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q08376-1", "protein_name": "Zinc finger and BTB domain-containing protein 14", "gene_name": "Zbtb14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDESNGQSKSKYCLKLNRPIGDAADAQDDDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALTFNDGMSEVKDEQTPGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHSERKQVTPSAIQSETEQLQAAAMAAEAEQQLETIACS", "length": 449 }, "evidence": [ { "id": "F1MB88", "url": "https://omabrowser.org/oma/group/F1MB88/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VKC4-1", "protein_name": "Promyelocytic leukemia zinc finger, isoform A", "gene_name": "Plzf", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLHSQTMQSIPTLHQPLHSKVSNYLNNQRRTGQFCDLLLELDSDDSLSLSVHFCVLAAQSQFINSNQKQQQFSIHNPLKITIRNFSCTQCLHTIVDFFYEDLVSVSKEHELHFRELAQILAVTELLNLYQLQPLGEAKEATEIPAPGEAQPNPDPEKKAEAVFENRQSYFKLKNPRAVKSSSKVNYCIGCDFKCYQVQKMIEHMGSCEPSHLICSLCEVGFLDWREYDTHLRRHSGDLRKPFFCLQCGIRFNTRAALLVHQPKHSTETPHICPHCGKGFKWKQGLSNHILVHNPEKQMLCDVCGYSTTHMKALKSHKLLHTGEFFACTVSGCKHRANRKENLKLHIETHKQGRDFICEVCGCKFSQSKNLKRHALKHTENGPNRYKCQLCGFSSHRSDKMKEHVQRVHTEKPVQLELSETVDSSFPDDFELPVIETSPKKKPKSVKSKTIRNVNPDKRLKTLLPKETVE", "length": 469 }, "evidence": [ { "id": "F1MB88", "url": "https://omabrowser.org/oma/group/F1MB88/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "F1MB88", "url": "https://www.uniprot.org/uniprotkb/F1MB88" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MB88", "url": "https://www.uniprot.org/uniprotkb/F1MB88" } ], "pmid": "" }, { "name": "regulation of immune system process", "id": "GO:0002682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002682", "evidence": [ { "database": "UniProtKB", "id": "F1MB88", "url": "https://www.uniprot.org/uniprotkb/F1MB88" } ], "pmid": "" }, { "name": "regulation of cytokine production", "id": "GO:0001817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817", "evidence": [ { "database": "UniProtKB", "id": "F1MB88", "url": "https://www.uniprot.org/uniprotkb/F1MB88" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": 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"Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MBH5", "url": "https://www.uniprot.org/uniprotkb/F1MBH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBH5-1", "url": "https://www.uniprot.org/uniprotkb/F1MBH5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFKHLRKWFVTRFFGRSRRRARLVSKDGRCNIEFGNVEAQSRLIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYVVAYVHKDLPEFHPPANHTPCVEHINGLTSAFLFSLETQVTIGYGFRCVTEQCGTAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLRTTITPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHTSPFFHMAAETLPQQDFELVVFLDGTVEATSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDARAKMKRGYDNPNFVLSEVNETDDTKM", "length": 372, "header": "tr|F1MBH5-1|F1MBH5_BOVIN Isoform 1 of Potassium inwardly rectifying channel subfamily J member 1 OS=Bos taurus OX=9913 GN=KCNJ1 PE=3 SV=2 CANONICAL=F1MBH5-1" }, "isoforms": [ { "isoform_ac": "F1MBH5-1", "url": "https://www.uniprot.org/uniprotkb/F1MBH5/entry", "sequence": { "sequence": "MFKHLRKWFVTRFFGRSRRRARLVSKDGRCNIEFGNVEAQSRLIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYVVAYVHKDLPEFHPPANHTPCVEHINGLTSAFLFSLETQVTIGYGFRCVTEQCGTAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLRTTITPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHTSPFFHMAAETLPQQDFELVVFLDGTVEATSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDARAKMKRGYDNPNFVLSEVNETDDTKM", "length": 372, "header": "tr|F1MBH5-1|F1MBH5_BOVIN Isoform 1 of Potassium inwardly rectifying channel subfamily J member 1 OS=Bos taurus OX=9913 GN=KCNJ1 PE=3 SV=2 CANONICAL=F1MBH5-1" }, "locus": { "chromosome": "29", "start_pos": 32215557, "end_pos": 32214442, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000008.5", "url": "https://www.ensembl.org/id/ENSBTAT00000000008.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000008.4", "url": "https://www.ensembl.org/id/ENSBTAP00000000008.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Mitochondrial ROMK channel is a molecular component of mitoK(ATP).", "journal": "Circulation research", "date": "2012-08-03", "authors": "Foster D Brian, Ho Alice S, Rucker Jasma, Garlid Anders O, Chen Ling, Sidor Agnieszka, Garlid Keith D, O'Rourke Brian", "evidence": [ { "database": "RefSeq", "id": "NP_001179136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179136" } ], "reference": [ { "type": "PubMed", "id": "22811560", "url": "https://glygen.org/publication/PubMed/22811560" } ] } ], "pathway": [ { "id": "bta:539250", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539250", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061I7A9-1", "protein_name": "ATP-sensitive inward rectifier potassium channel 1", "gene_name": "Kcnj1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": 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"MFNYLRKRFASHITERSRRKARLVSKDGRCNIEFGNVEQSRFVFLIDIWTTILDLRWRYKMTIFISAFLGSWFLFGLLWYVVAYIHKDLPEFNPSINHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCVTAIFLLIFQSILGVIINSFMCGAILAKISRSKNRAKTITFSRNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTITPEGETIILDQVNIEFIVDAGNENLFFISPLTIYHIIDKNSPFFHMAAETILQQDFELVVFLDGTVEATSATCQVRTSYIPEEVLWGYRFAPIVSKTKEGKYRVDFQNFSKTVAVEMPHCAFCLYNEKEAKAKEKKGYDNPGFVLAEASEASDTKM", "length": 371 }, "evidence": [ { "id": "F1MBH5", "url": "https://omabrowser.org/oma/group/F1MBH5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O88335-1", "protein_name": "ATP-sensitive inward rectifier potassium channel 1", "gene_name": "Kcnj1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"go_terms": [ { "name": "regulation of monoatomic ion transmembrane transport", "id": "GO:0034765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034765", "evidence": [ { "database": "UniProtKB", "id": "F1MBH5", "url": "https://www.uniprot.org/uniprotkb/F1MBH5" } ], "pmid": "" }, { "name": "potassium ion import across plasma membrane", "id": "GO:1990573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990573", "evidence": [ { "database": "UniProtKB", "id": "F1MBH5", "url": "https://www.uniprot.org/uniprotkb/F1MBH5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 324, "end_pos": 326, "annotation": "n_glycosylation_sequon" }, { "start_pos": 365, "end_pos": 367, "annotation": "n_glycosylation_sequon" }, { "start_pos": 98, "end_pos": 100, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29463", "name": "", "equation": "K(+)(in) = K(+)(out)", "summary": "", "cellular_location": "", 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"evidence": [ { "id": "F1MBI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBI9" } ] }, { "name": "LOC614208", "type": "synonym", "evidence": [ { "id": "XP_059747831", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747831" } ] } ], "protein_names": [ { "name": "Glycine cleavage system H protein", "type": "recommended", "evidence": [ { "id": "F1MBI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBI9/entry#names_and_taxonomy" } ] }, { "name": "glycine cleavage system H protein, mitochondrial-like", "type": "synonym", "evidence": [ { "id": "XP_059747831", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747831" } ] } ], "function": [ { "annotation": "The H protein shuttles the methylamine group of glycine from the P protein to the T protein.", "evidence": [ { "database": "UniProtKB", "id": "F1MBI9", "url": "https://www.uniprot.org/uniprotkb/F1MBI9#function" }, { "database": "UniProtKB", "id": "RU364055", "url": "https://www.uniprot.org/uniprotkb/RU364055#function" } ] }, { "annotation": "The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST).", "evidence": [ { "database": "UniProtKB", "id": "F1MBI9", "url": "https://www.uniprot.org/uniprotkb/F1MBI9#function" }, { "database": "UniProtKB", "id": "ARBA00046240", "url": "https://www.uniprot.org/uniprotkb/ARBA00046240#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MBI9", "url": "https://www.uniprot.org/uniprotkb/F1MBI9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC614208", "url": "https://www.uniprot.org/uniprotkb/F1MBI9", "locus": {} } ], "crossref": [ { "id": "F1MBI9", "url": "https://alphafold.ebi.ac.uk/entry/F1MBI9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023860", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023860", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06848", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06848", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "614208", "url": "https://www.ncbi.nlm.nih.gov/gene/614208", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000089", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000089", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011053", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011053", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017453", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017453", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033753", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033753", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:614208", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614208", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HEWVEMV", "url": "https://omabrowser.org/oma/group/HEWVEMV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11715", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11715", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11715:SF42", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11715:SF42", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01597", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01597", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059747831", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747831", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MBI9", "url": "https://www.uniprot.org/uniprotkb/F1MBI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBI9-1", "url": "https://www.uniprot.org/uniprotkb/F1MBI9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALRAVRSVRAAVGGLRAISAPSAPCSPRPWGLRAGAVRELRTGPALLSVRKFTEKHEWVTTENGVGTVGISNFAQEALGDVVYCSLPEVGTKLNKQEEFGALESVKASSELYSPLSGEVTEINKALAENPGLVNKSCYEDGWLIKMTFSNPSELDELMSEEAYEK", "length": 166, "header": "tr|F1MBI9-1|F1MBI9_BOVIN Isoform 1 of Glycine cleavage system H protein OS=Bos taurus OX=9913 GN=LOC614208 PE=3 SV=3 CANONICAL=F1MBI9-1" }, "isoforms": [ { "isoform_ac": "F1MBI9-1", "url": "https://www.uniprot.org/uniprotkb/F1MBI9/entry", "sequence": { "sequence": "MALRAVRSVRAAVGGLRAISAPSAPCSPRPWGLRAGAVRELRTGPALLSVRKFTEKHEWVTTENGVGTVGISNFAQEALGDVVYCSLPEVGTKLNKQEEFGALESVKASSELYSPLSGEVTEINKALAENPGLVNKSCYEDGWLIKMTFSNPSELDELMSEEAYEK", "length": 166, "header": "tr|F1MBI9-1|F1MBI9_BOVIN Isoform 1 of Glycine cleavage system H protein OS=Bos taurus OX=9913 GN=LOC614208 PE=3 SV=3 CANONICAL=F1MBI9-1" }, "locus": { "chromosome": "11", "start_pos": 94935069, "end_pos": 94934572, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027932.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027932.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027932.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027932.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:614208", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614208", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BA24-1", "protein_name": "Glycine cleavage system H protein", "gene_name": "GCSH", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALRAARTLRAAVSNLRAVSAPAAPCLPRPWGLQAGAIRLLRTSPALLSVRKFTDKHEWITTENGIGTVGISNFAQEALGDVVYCSLPEVGTKLNKQEEFGALESVKAASELYSPLSGEVTAINEALAENPGLVNKSCYEDGWLIKMTLSNPSELDELMSEEAYEKYIKSIEE", "length": 173 }, "evidence": [ { "id": "F1MBI9", "url": "https://omabrowser.org/oma/group/F1MBI9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q54JV8-1", "protein_name": "Probable glycine cleavage system H protein 1, mitochondrial", "gene_name": "gcvH1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MLKTLRFGTRAFGQNLNIAKRNFCTRYTNDHEWVTSLGSQNYRLGITDFAQKQLGDIVFVEIPQIGATLSQGQPITVVESVKAASDIYIPMDGSITTVNQELESSPELVNEEPMGDGWIVEYKSSKTDQFQSLMNKAQYDEYIKEH", "length": 146 }, "evidence": [ { "id": "F1MBI9", "url": "https://omabrowser.org/oma/group/F1MBI9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q91WK5-1", "protein_name": "Glycine cleavage system H protein, mitochondrial", "gene_name": "Gcsh", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLQVSRSLRVVAYSLRTALTFCSPRPCVPSAAAVRSLRTGSALLSVRKFTEKHEWITTEEGIGTVGISNFAQEALGDVVYCSLPEVGTKLKKQEEFGALESVKAASELYSPLSGEVTEVNEALAENPGLVNKSCYEDGWLIKMTLSDPSEMDELMSEEAYEKYVKSIEE", "length": 170 }, "evidence": [ { "id": "F1MBI9", "url": "https://omabrowser.org/oma/group/F1MBI9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1MBI9", "url": "https://www.uniprot.org/uniprotkb/F1MBI9" } ], "pmid": "" }, { "name": "glycine cleavage complex", "id": "GO:0005960", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005960", "evidence": [ { "database": "UniProtKB", "id": "F1MBI9", "url": "https://www.uniprot.org/uniprotkb/F1MBI9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "glycine decarboxylation via glycine cleavage system", "id": "GO:0019464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019464", "evidence": [ { "database": "UniProtKB", "id": "F1MBI9", "url": "https://www.uniprot.org/uniprotkb/F1MBI9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 135, "end_pos": 137, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MBI9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 166, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MBI9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MBI9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MBI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBI9" }, { "id": "PS50968", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50968" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Lipoyl-binding", "eco_id": "ECO_0000259", "start_pos": 66, "end_pos": 148, "start_aa": "Val", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 135, "end_pos": 137 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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{ "name": "GCFC", "type": "synonym", "evidence": [ { "id": "NP_001069157", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069157" } ] }, { "name": "PAXBP1", "type": "synonym", "evidence": [ { "id": "NP_001069157", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069157" } ] } ], "protein_names": [ { "name": "GC-rich sequence DNA-binding factor 1", "type": "synonym", "evidence": [ { "id": "NP_001069157", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069157" } ] }, { "name": "GC-rich sequence DNA-binding factor homolog", "type": "synonym", "evidence": [ { "id": "NP_001069157", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069157" } ] }, { "name": "PAX3 and PAX7 binding protein 1", "type": "synonym", "evidence": [ { "id": "F1MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBJ4/entry#names_and_taxonomy" } ] }, { "name": "PAX3- and PAX7-binding protein 1", "type": "synonym", "evidence": [ { "id": "NP_001069157", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069157" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MBJ4", "url": "https://www.uniprot.org/uniprotkb/F1MBJ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PAXBP1", "url": "https://www.uniprot.org/uniprotkb/F1MBJ4", "locus": { "chromosome": "1", "start_pos": 2819637, "end_pos": 2786613, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003064", "url": "https://www.ensembl.org/id/ENSBTAG00000003064" } ] } } ], "crossref": [ { "id": "F1MBJ4", "url": "https://alphafold.ebi.ac.uk/entry/F1MBJ4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003064", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003064", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514918", "url": "https://www.ncbi.nlm.nih.gov/gene/514918", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR012890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514918", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514918", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MKNICLW", "url": "https://omabrowser.org/oma/group/MKNICLW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MBJ4", "url": "https://www.orthodb.org/?gene=F1MBJ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12214", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12214", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12214:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12214:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07842", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07842", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069157", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MBJ4", "url": "https://www.uniprot.org/uniprotkb/F1MBJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBJ4-1", "url": "https://www.uniprot.org/uniprotkb/F1MBJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPPGTGEEPGPGGGGGDRAPAGESLLGPGPPPPPPPPAALTSGTEAGGCLPGGLEPGNGLKPRKRPRENKEVPRASLLSFQDEDEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNSSADNEPPLDKAGHVKDTSLEDGVIISEHGEDEMDMESEKEEEKPKAGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARELGDFTPHDSEPGKGRLVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPTEVNMYYQNTYQTMPYGSSYGIPYSYSAYGSSDAKSQKTDNTVPFKTPSNEMTPVTIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSRADSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHSNKALMAPNLDSFGRDRALYQEHAKRRIAEREARRTRRRQAREQTGKMADHLEGLSSDDEETSTDITNFNLEKDRISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLLNPLIRLQLLTWTPLEAKCRDFENMLWFESLLFYGCEEREQEKDDVDVALLPTIVEKVILPKLTVIAENMWDPFSTTQTSRMVGITLKLINGYPSVVNAENKNTQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLLASVRALDHAMSVASDHNVKEFKSLIEGK", "length": 922, "header": "tr|F1MBJ4-1|F1MBJ4_BOVIN Isoform 1 of PAX3 and PAX7 binding protein 1 OS=Bos taurus OX=9913 GN=PAXBP1 PE=3 SV=2 CANONICAL=F1MBJ4-1" }, "isoforms": [ { "isoform_ac": "F1MBJ4-1", "url": "https://www.uniprot.org/uniprotkb/F1MBJ4/entry", "sequence": { "sequence": "MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPPGTGEEPGPGGGGGDRAPAGESLLGPGPPPPPPPPAALTSGTEAGGCLPGGLEPGNGLKPRKRPRENKEVPRASLLSFQDEDEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNSSADNEPPLDKAGHVKDTSLEDGVIISEHGEDEMDMESEKEEEKPKAGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARELGDFTPHDSEPGKGRLVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPTEVNMYYQNTYQTMPYGSSYGIPYSYSAYGSSDAKSQKTDNTVPFKTPSNEMTPVTIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSRADSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHSNKALMAPNLDSFGRDRALYQEHAKRRIAEREARRTRRRQAREQTGKMADHLEGLSSDDEETSTDITNFNLEKDRISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLLNPLIRLQLLTWTPLEAKCRDFENMLWFESLLFYGCEEREQEKDDVDVALLPTIVEKVILPKLTVIAENMWDPFSTTQTSRMVGITLKLINGYPSVVNAENKNTQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLLASVRALDHAMSVASDHNVKEFKSLIEGK", "length": 922, "header": "tr|F1MBJ4-1|F1MBJ4_BOVIN Isoform 1 of PAX3 and PAX7 binding protein 1 OS=Bos taurus OX=9913 GN=PAXBP1 PE=3 SV=2 CANONICAL=F1MBJ4-1" }, "locus": { "chromosome": "1", "start_pos": 2817777, "end_pos": 2786812, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003986.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003986.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003986.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003986.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514918", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514918", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A8C8-1", "protein_name": "PAX3 and PAX7 binding protein 1", "gene_name": "Paxbp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPASGEEPGPGGGDRAPAGESLLGPGPPPPPSAHTPGLGAEAGGGIPGGAEPGNGLKQRKRPRENKEVPRASLLSFQDEEEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELSAAADSDQPLDKMCHAKDTNPEDGVVISEHGEDEMDMESEKEEEKPKAGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQLARELGDFTPHDSEPGKGRLVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPTEVNMYYQNTYQTMPYGASYGVPYSYTAYGSSDAKSQKSDNTVPFKTPSNEAAPITIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHSNKALMAPNLDSFGRDRALYQEHAKRRIAEEAGIPYLNPPINLLSRTRRRQAREQTGQMADHLEGLSSDDEETSTDITNFNLERDRILKESSKVFEDVLESFCSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLEAKCRDFENMLWFESLLFYGCEEREQEKDDVDVALLPTIVEKVILPKLTVIAENMWDPFSTTQTSRMVGITLKLINGYPSVVNAENKNTQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIRKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLLASVRALDHAVSVASDHNVKEVKSLIEGK", "length": 929 }, "evidence": [ { "id": "F1MBJ4", "url": "https://omabrowser.org/oma/group/F1MBJ4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9QDJ4-1", "protein_name": "PAX3- and PAX7-binding protein 1", "gene_name": "paxbp1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFKKAKRCNFRRRNDSEDEEKEEQQQSGGPGAEDSASPSESGSGPAPGANVLNNHGNGFQPGAVKAVKEKKKRKEIREEPKASLLSFQDDEDEAEVFRVKKSNHSKKIVKQLKKEYKEDLEKTVPEQSTRIGGQNLTIKEEPLEGSRASSEQGEEEMEVDSNEDQEEEGDQKSAGGAFKENLSALSLLRPGEIPDAAFIHAARKRRQMARELGGDTPLVENDPTNKRLVHEDENGDMDDDEDEKRIVFSGVNTKSQRQKIAEEIGIEGSDDEALDNGQDEEVSRWEQEQIRKGISIPQVQTQPEDTSMYYQGSYDAQPYGASYAMPFNYATAVAGVDNSKPLKAEPSVPYPIPSCELTPITTDLVKKRLQDRLSFMRQGHNTNARRYQQIQEDLEASKKAIRVLEGSSVEAADKYRFLQEMRGYVGDLLECLSEKVPVILELEAAMHQLLRQRASRLVQRRQDDIKDESSEFSSLSSKAVMAPNLDSFGRDRTAYLELAKQRRIAEREARRTRRRQAREQNDKRAEHKEGLSSDDEETSTDITSFDSERERILKESKKVFEDVVEDFHSLDNIKSHFETWRKLYYSCYRDAYIGLCLPKLFNPLIRLQLISWSPLEVECSNFEYMLWFESLLFYGCGEQSALKKEEDVDNNLLPAIVERVLLPKLAVLTDQIWDPLSNSQTYRLVAFMKRLVKDYPTVLHGENRNTQELLRTVIMRIRRTLDDDIFLPLFPKNVMENKNSGAYLFSQRQFWSCVKFLGNILMWDGILSLSVLKDLAIDSTLNRYILSALQTTDASEEHVEKCRRVVECFPVQWFSSLKGQQTLPPLENFCRFLKHLSSSLYRSCVAGSDVEKRNVREHIKEVIRLLGRLNALDHVITVASEHGIKDIKTLLEKK", "length": 894 }, "evidence": [ { "id": "F1MBJ4", "url": "https://omabrowser.org/oma/group/F1MBJ4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1SH07-1", "protein_name": "PAX3 and PAX7 binding protein 1", "gene_name": "PAXBP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPGTGEEPGPGDRAPGGESLLGPGLPPPPSALAPGPGTEAGGCFPGGAEPGNGLKPRKRPRENKEVPRASLLSFQDEDEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNSLADNELPLDKTGHVKDASQEDGVIISEHGEDEMDMESEKEEEKPKAGGTFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARELGDFTPHDNEPGKGRLVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDALVAGEQDEELSRWEQEQIRKGINIPQVQASQPTEVNMYYPNTYQTMPYGSSYGIPYSYTAYGSSDAKSQKTDNTVPFKTPSNEMTPVTIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHSNKALMAPNLDSFGRDRALYQEHAKRRIAEREARRTRRRQAREQTGKMADHLEGLSSDDEETSTDITNFNLEKDRISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLEAKCRDFENMLWFESLLFYGCEEREQEKDDVDVALLPTIVEKVILPKLTVIAENMWDPFSTTQTSRMVGITLKLINGYPSVVNAENKNTQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLLASVRALDHALSVASDHNVKEFKSLIEGK", "length": 916 }, "evidence": [ { "id": "F1MBJ4", "url": "https://omabrowser.org/oma/group/F1MBJ4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P58501-1", "protein_name": "PAX3- and PAX7-binding protein 1", "gene_name": "Paxbp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPASGEEPGPGGGDRAPAGESLLGPGPLPPPPSAHHPGLGAEAGGGISGGAEPGNGLKPRKRPRENKEVPRASLLSFQDEEEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNTAADSDQPLDKTCHAKDTNPEDGVVISEHGEDEMDMESEKEEEKPKAGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQLARELGDFTPHDSEPGKGRLVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPSEVNVYYQNTYQTMPYGASYGIPYSYTAYGSSDAKSQKTDNTVPFKTPSNEMAPVTIDLVKRQLKDRLDSMKELHKTNQQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHSNKALMAPNLDSFGRDRALYQEHAKRRIAEREARRTRRRQAREQTGQMADHLEGLSSDDEETSTDITNFNLEKDRILKESSKVFEDVLESFYSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLEAKCRDFETMLWFESLLFYGCEDREQEKDEADVALLPTIVEKVILPKLTVIAETMWDPFSTTQTSRMVGITMKLINGYPSVVNADNKNTQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIRKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLLASVRALDHAISVASDHNVKEVKSLIEGK", "length": 919 }, "evidence": [ { "id": "F1MBJ4", "url": "https://omabrowser.org/oma/group/F1MBJ4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54JF1-1", "protein_name": "GC-rich sequence DNA-binding factor-like protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNFSSINKNKQRQIRKKVIETEENNEDDEKKKLENENENGNENEQTIKSIVVEQAKKKKGANTFSTKNKIAKKATLNLFSFGEDEENGEQEQDSEQQQQQQFNSSIKFNPISVRKNDSIFEDSKTTTINNESLGQYTTEMINSLKKNTSSKPTKSSSNDNNHNDNNHNDNNDIDYKMDIDHQQFKDDHDDKENTTSSSSSSFTIPTVEQIKLAKEKRQRVRDGKWQDTTEKSSSSSTSTSKSLSKDFLPLKVSANNGNDKDDNDNGSRLIREEDDDDEMEEYNIKPSNTIKFGDPGKSNKRDEVGQAVNIENSKNKNDDQDEDEDEDEEIIRWRLEQIKKGGGLKDSQLQSIEFQKRKMEKELLLLGPSSENSLSPYYKSSSYLINSPKLSNNSNNNNNNNNNNQQQHSFIESICKDLNSILIQLNEVKHNHESEFEKVQEALRDSVIQLSIMESEKHVSHDQYIYYDEIKSYCNNMIDCLSEKIPQIEQLDDKYIELLKDYAYDIRKQFKQTLHDQINDIQDNELSNNNKISFNNKEGEDKEDLDEFGRDRSHYEKSSRKKRLEQYKQLIVSLNNTDGNDDFKLHQISDENFYKNEKEKILNSIKSIMDDVDPDFCDINYIADKFKHWKSKDLKSYQKAQMPFIMPSILAPFIRLQMIDWSPLDDIYFDTMSWYNQLFSYGGGGGDDDDILIPKLVEKIIIPKVETFITYIWNPLSKSQTTNLKNTIDEILIYINDENHQNNNNNNNNNNNNNNNNNNNNNNNNVNQEVKFLFSQILSTLNYSISNGNLLIPYSNRDLTFSIKMYMYSLTMLDSIKIWSSNYQYIQLDSLMNLSDDIIDFQILPFLHKIYSLQHHHNYQQHQQQQQQQQQQQQQSFNIDNLFYLFELFYQYLLTLPWSNKKYKSSVISLLLKLKNDHENENGGLLNVENFSKLNNLYIPYFT", "length": 943 }, "evidence": [ { "id": "F1MBJ4", "url": "https://omabrowser.org/oma/group/F1MBJ4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9FNN3-1", "protein_name": "Transcriptional repressor ILP1", "gene_name": "ILP1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGSNRPKNFRRRGDDGGDEIDGKVATPSSKPTSTLSSSKPKTLSASAPKKKLLSFADDEEEEEDGAPRVTIKPKNGRDRVKSSSRLGVSGSSHRHSSTKERRPASSNVLPQAGSYSKEALLELQKNTRTLPYSRSSANAEPKVVLKGLIKPPQDHEQQSLKDVVKQVSDLDFDEEGEEEQHEDAFADQAAIIRAKKERMRQSRSAPAPDYISLDGGIVNHSAVEGVSDEDADFQGIFVGPRPQKDDKKGVFDFGDENPTAKETTTSSIYEDEDEEDKLWEEEQFKKGIGKRMDEGSHRTVTSNGIGVPLHSKQQTLPQQQPQMYAYHAGTPMPNVSVAPTIGPATSVDTLPMSQQAELAKKALKDNVKKLKESHAKTLSSLTKTDENLTASLMSITALESSLSAAGDKYVFMQKLRDFISVICDFMQNKGSLIEEIEDQMKELNEKHALSILERRIADNNDEMIELGAAVKAAMTVLNKHGSSSSVIAAATGAALAASTSIRQQMNQPVKLDEFGRDENLQKRREVEQRAAARQKRRARFENKRASAMEVDGPSLKIEGESSTDESDTETSAYKETRDSLLQCADKVFSDASEEYSQLSKVKARFERWKRDYSSTYRDAYMSLTVPSIFSPYVRLELLKWDPLHQDVDFFDMKWHGLLFDYGKPEDGDDFAPDDTDANLVPELVEKVAIPILHHQIVRCWDILSTRETRNAVAATSLVTNYVSASSEALAELFAAIRARLVEAIAAISVPTWDPLVLKAVPNTPQVAAYRFGTSVRLMRNICMWKDILALPVLENLALSDLLFGKVLPHVRSIASNIHDAVTRTERIVASLSGVWTGPSVTRTHSRPLQPLVDCTLTLRRILEKRLGSGLDDAETTGLARRLKRILVELHEHDHAREIVRTFNLKEAV", "length": 908 }, "evidence": [ { "id": "F1MBJ4", "url": "https://omabrowser.org/oma/group/F1MBJ4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VI54-1", "protein_name": "GCF C-terminal domain-containing protein", "gene_name": "Dmel\\CG1965", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSLFRKPKKIQRRVFSSNADEEEDGASLDPDAEMEAPPPPIISGKREKEKSRKAIKPQEDNSKPKALLSFADDEDDGEVFQVRKSSHSKKVMRMLDKERRKKKREERAENSGHPGGENGSTQHLESSGGPSSGPPNSNSNPANAGRYKSASDQSKSKKSDNHMIQTEIRTDDFVLVVKKSETPEAILNGRAALCAGREDMSDEEDQQSEDGGHDKTRHRFSKPEHLKQMLESGSIPDAAMIHAARKRRQRAREQGAGDYIPIEEPKEPAKLSNRLPCEDVEGDQSDDEERMDMNDITGRKEREERREQFYAVENDSTDGDSDREMNEWENQQIRKGVTAAQLVHSQHETVLSRFMIKPAPSGIGTGMDDGDSTAAQSTSTLLEQAYAKNALERTNLAAAVRSSVKTKKEKAKATALRTPQEILAAIQSRLSELKERSADHSASMARISTELKALKLQQLECQQNAPTAAAKYKFYQEIKCYVNDLVDCLSEKAPVIYDLEKRALQQYGKNQRYLVNRRRQDVRDQAKEIAESAKPITAASRRTPDYEEQVRRAAEREGRRTRRRCERERNDLLSSHLDGMSSDDEIADQQQELSVTTMAQIESQSVDALEDVTDDFSKIELILMKFFAWRKTDMSSYQDAFVSLCLPKVLAPLVRHELVLWSPLLDVYADIENMRWYQACMLYASQADETVEQLKIDPDINLVPALIEKIVLPKVTALVTECWDPLSTTQTLRLVGFINRLGREFPLSGTNKQLNKLFESIMERMRLALENDVFIPIFPKQVQEAKTSFFQRQFCSGLKLFRNFLSWQGILADKLLRELAIGALLNRYLLLAMRVCTPNDAINKAYIIVNTLPTVWLLPNSETLKNMELFIGYIKQTLENCDASNPIFMQSSDKAKQILQRLHSL", "length": 905 }, "evidence": [ { "id": "F1MBJ4", "url": "https://omabrowser.org/oma/group/F1MBJ4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y5B6-1", "protein_name": "PAX3- and PAX7-binding protein 1", "gene_name": "PAXBP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFRKARRVNVRKRNDSEEEERERDEEQEPPPLLPPPGTGEEAGPGGGDRAPGGESLLGPGPSPPSALTPGLGAEAGGGFPGGAEPGNGLKPRKRPRENKEVPRASLLSFQDEEEENEEVFKVKKSSYSKKIVKLLKKEYKEDLEKSKIKTELNSSAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMESEKEEEKPKTGGAFSNALSSLNVLRPGEIPDAAFIHAARKKRQMARELGDFTPHDNEPGKGRLVREDENDASDDEDDDEKRRIVFSVKEKSQRQKIAEEIGIEGSDDDALVTGEQDEELSRWEQEQIRKGINIPQVQASQPAEVNMYYQNTYQTMPYGSSYGIPYSYTAYGSSDAKSQKTDNTVPFKTPSNEMTPVTIDLVKKQLKDRLDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHSNKALMAPNLDSFGRDRALYQEHAKRRIAEREARRTRRRQAREQTGKMADHLEGLSSDDEETSTDITNFNLEKDRISKESGKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLEAKCRDFENMLWFESLLFYGCEEREQEKDDVDVALLPTIVEKVILPKLTVIAENMWDPFSTTQTSRMVGITLKLINGYPSVVNAENKNTQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFFQRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLLASVRALDHAMSVASDHNVKEFKSLIEGK", "length": 917 }, "evidence": [ { "id": "F1MBJ4", "url": "https://omabrowser.org/oma/group/F1MBJ4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MBJ4", "url": "https://www.uniprot.org/uniprotkb/F1MBJ4" } ], "pmid": "" }, { "name": "histone methyltransferase binding", "id": "GO:1990226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990226", "evidence": [ { "database": "UniProtKB", "id": "F1MBJ4", "url": "https://www.uniprot.org/uniprotkb/F1MBJ4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MBJ4", "url": "https://www.uniprot.org/uniprotkb/F1MBJ4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1MBJ4", "url": "https://www.uniprot.org/uniprotkb/F1MBJ4" } ], "pmid": "" }, { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "F1MBJ4", "url": "https://www.uniprot.org/uniprotkb/F1MBJ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 14, "end_pos": 16, "annotation": "n_glycosylation_sequon" }, { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 797, "end_pos": 799, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MBJ4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 922, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MBJ4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MBJ4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBJ4" }, { "id": "PF07842", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GCF C-terminal", "eco_id": "ECO_0000259", "start_pos": 601, "end_pos": 812, "start_aa": "Asp", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 14, "end_pos": 16 }, { "start_pos": 158, "end_pos": 160 }, { "start_pos": 797, "end_pos": 799 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MBJ5-1", "uniprot_ac": "F1MBJ5", "uniprot_id": "F1MBJ5_BOVIN", "mass": { "chemical_mass": 57628.0, "monoisotopic_mass": 57628.0 }, "refseq": {}, "gene_names": [ { "name": "SMG9", "type": "recommended", "evidence": [ { "id": "F1MBJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBJ5" } ] } ], "protein_names": [ { "name": "Nonsense-mediated mRNA decay factor SMG9", "type": "recommended", "evidence": [ { "id": "F1MBJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBJ5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8. Plays a role in brain, heart, and eye development.", "evidence": [ { "database": "UniProtKB", "id": "F1MBJ5", "url": "https://www.uniprot.org/uniprotkb/F1MBJ5#function" }, { "database": "UniProtKB", "id": "ARBA00059168", "url": "https://www.uniprot.org/uniprotkb/ARBA00059168#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MBJ5", "url": "https://www.uniprot.org/uniprotkb/F1MBJ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMG9", "url": "https://www.uniprot.org/uniprotkb/F1MBJ5", "locus": { "chromosome": "18", "start_pos": 51935743, "end_pos": 51956086, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011815", "url": "https://www.ensembl.org/id/ENSBTAG00000011815" } ] } } ], "crossref": [ { "id": "F1MBJ5", "url": "https://alphafold.ebi.ac.uk/entry/F1MBJ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011815", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011815", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039177", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039177", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SEYYPHL", "url": "https://omabrowser.org/oma/group/SEYYPHL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR14270", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14270", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14270:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14270:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-975957", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MBJ5", "url": "https://www.uniprot.org/uniprotkb/F1MBJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBJ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MBJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSESGHSQPGLYGIERRRRWKEPGPGGPQNLSGPGGRERDYIAPWERERRDGSEETSTAVMQKTPIILSKPPAERSKQPPPPAAPAAPPAPAPLEKPIVLMKPREEGKGPAATTSTSTPEGTAPPPPAAPVPPKGEKEGQRPTQPVYQIQNRGMGTAAPAAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRAYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHESSSSSGSEEGAEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLMPFMDSETESETPPRAGPGSSSLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVKKSSALAEYSRLLA", "length": 520, "header": "tr|F1MBJ5-1|F1MBJ5_BOVIN Isoform 1 of Nonsense-mediated mRNA decay factor SMG9 OS=Bos taurus OX=9913 GN=SMG9 PE=3 SV=3 CANONICAL=F1MBJ5-1" }, "isoforms": [ { "isoform_ac": "F1MBJ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MBJ5/entry", "sequence": { "sequence": "MSESGHSQPGLYGIERRRRWKEPGPGGPQNLSGPGGRERDYIAPWERERRDGSEETSTAVMQKTPIILSKPPAERSKQPPPPAAPAAPPAPAPLEKPIVLMKPREEGKGPAATTSTSTPEGTAPPPPAAPVPPKGEKEGQRPTQPVYQIQNRGMGTAAPAAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRAYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHESSSSSGSEEGAEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLMPFMDSETESETPPRAGPGSSSLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVKKSSALAEYSRLLA", "length": 520, "header": "tr|F1MBJ5-1|F1MBJ5_BOVIN Isoform 1 of Nonsense-mediated mRNA decay factor SMG9 OS=Bos taurus OX=9913 GN=SMG9 PE=3 SV=3 CANONICAL=F1MBJ5-1" }, "locus": { "chromosome": "18", "start_pos": 51952686, "end_pos": 51936170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015684.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015684.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015684.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015684.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-975957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-975957", "resource": "Reactome", "description": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" } ], "orthologs": [ { "uniprot_canonical_ac": "E7F7F6-1", "protein_name": "Nonsense-mediated mRNA decay factor SMG9", "gene_name": "smg9", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSESGHSQPGLYGQGRRRRRRRERDPAGPPGQNLSGPSRDRDYVPRERRDGSEESTGPLLQKTPIILAKPPGERSKASAPASGPPSLEKPIMLIKTRDEGGKPGNPPDIPPSASGAGTAKMEREGQRPTQPVYQIQNRGMGSAASGGAVDPVIGQTKLLPPEKMKHSIKLVDDQMNWCDSAMEYLRDQTDMLVVGVIGLQGTGKSTIMSLLSANSPEEDQRAYVFRAQTQEIKERAGNQSSGIDFYITQERVIFLDTQPVLSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQITAFLFTVCHVVIVIQDWFTDINLYRFLQTAEMLKPSTPSASHDSTGSSGPDDGSEYYPHIVFLQNKARREEFCPRNLKKMHMAVDKLMAHSHLKYKGTLSMLDCNIFPGLSRDYMETEVNLFLLPLMENDGEDALTRAGSGPPLFSLLPGYRGHPNFSSLVSKFRSQILAMSRSQLSHTILTEKNWFHYAARIWDGVKKSSALSEYSRLLS", "length": 505 }, "evidence": [ { "id": "F1MBJ5", "url": "https://omabrowser.org/oma/group/F1MBJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1RMV1-1", "protein_name": "Nonsense-mediated mRNA decay factor SMG9", "gene_name": "SMG9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSESGHSQPGLYGMERRRRWKEPGPGGPQNLSGPGGRERDYIAPWERERRDGSEEPGTAVMQKTPIILSKPPAERSKQPAPPAAPAAPPAPAPLEKPIVLMKPREEGKGPAASTPASTPEGTTPPPPAAPTPPKGEKEGQRPTQPVYQIQNRGMGTAAPAAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRAYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHESSSSSGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLVPFMDSEAESENPPRAGPGSSPLFSLLPGYQGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVKKSSALAEYSRLLA", "length": 520 }, "evidence": [ { "id": "F1MBJ5", "url": "https://omabrowser.org/oma/group/F1MBJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5PQS6-1", "protein_name": "Nonsense-mediated mRNA decay factor SMG9", "gene_name": "Smg9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSESGHSQPGLYGIERRRRWKEPGSSGPQNLSGPGGRERDYIAPWERERRDGSEDPSTNVMQKTPIILSKPPAERSKQPPPSTAPAAPPAPAPLEKPIVLMKPREEGKGPVAATGASTPEGTAPPPPTAPAPPKGEKEGQRPTQPVYQIQNRGMGTAAPTAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRAYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHESSSAAGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQLMAHSHLRYKGTLSMLQCNIFPGLPPDFLDAEVNLFLVPFMDSEAENENPPRAGPGSSPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVKKSSALAEYSRLLA", "length": 520 }, "evidence": [ { "id": "F1MBJ5", "url": "https://omabrowser.org/oma/group/F1MBJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DB90-1", "protein_name": "Nonsense-mediated mRNA decay factor SMG9", "gene_name": "Smg9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSESGHSQPGLYGIERRRRWKEPGSSGPQNLSGPGGRERDYIAPWERERRDGSEDPSTNVMQKTPIILSKPPAERSKQPPPSTAPAAPPAPAPLEKPIVLMKPREEGKGPVAGTGASTPEGTAPPPPTAPAPPKGEKEGQRPTQPVYQIQNRGMGTAAPTAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRAYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHESSSSAGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDAEVNLFLVPFMDSEAENENPPRAGPGSSPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVKKSSALAEYSRLLA", "length": 520 }, "evidence": [ { "id": "F1MBJ5", "url": "https://omabrowser.org/oma/group/F1MBJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H0W8-1", "protein_name": "Nonsense-mediated mRNA decay factor SMG9", "gene_name": "SMG9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSESGHSQPGLYGIERRRRWKEPGSGGPQNLSGPGGRERDYIAPWERERRDASEETSTSVMQKTPIILSKPPAERSKQPPPPTAPAAPPAPAPLEKPIVLMKPREEGKGPVAVTGASTPEGTAPPPPAAPAPPKGEKEGQRPTQPVYQIQNRGMGTAAPAAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRTYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHESSSSSGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLFLVPFMDSEAESENPPRAGPGSSPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVRKSSALAEYSRLLA", "length": 520 }, "evidence": [ { "id": "F1MBJ5", "url": "https://omabrowser.org/oma/group/F1MBJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "F1MBJ5", "url": 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377425" }, "gene_names": [ { "name": "OR10AG65", "type": "recommended", "evidence": [ { "id": "F1MBK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBK2" } ] }, { "name": "OR10AG65", "type": "synonym", "evidence": [ { "id": "NP_001377425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377425" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1MBK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBK2/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 10AG1", "type": "synonym", "evidence": [ { "id": "NP_001377425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377425" } ] }, { "name": "olfactory receptor family 10 subfamily AG member 65", "type": "synonym", "evidence": [ { "id": "NP_001377425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377425" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377425" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MBK2", "url": "https://www.uniprot.org/uniprotkb/F1MBK2#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MBK2", "url": "https://www.uniprot.org/uniprotkb/F1MBK2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR10AG65", "url": "https://www.uniprot.org/uniprotkb/F1MBK2", "locus": { "chromosome": "15", "start_pos": 78585013, "end_pos": 78585930, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057389", "url": "https://www.ensembl.org/id/ENSBTAG00000057389" } ] } } ], "crossref": [ { "id": "F1MBK2", "url": "https://alphafold.ebi.ac.uk/entry/F1MBK2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020746", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020746", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15225", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15225", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "787543", "url": "https://www.ncbi.nlm.nih.gov/gene/787543", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:787543", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787543", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MBK2", "url": "https://www.orthodb.org/?gene=F1MBK2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377425", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MBK2", "url": "https://www.uniprot.org/uniprotkb/F1MBK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBK2-1", "url": "https://www.uniprot.org/uniprotkb/F1MBK2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEFVLLDFADVPHLQRFLFGLFLLIYIIILMGNGIIFLITKLDPGLQTPMYFFLGNFSLLEICYVSVTLPRMLTSLWTQRRTISLVACATQMCFILTLGATECFLLAVMAYDRYVAICSPLQYPLVMNYRVCIQLVASSWISGIPIQIGQTCQIFSLPFCGSNLLNHFFCDIPPILKLACGDTFLNEMLVFTVAALFVLVPFLLILVSYGKIISTVLKLPSATSRGKAFSTCSSHLMVVALFFGSGLVTYLRPKTQGSAGTDKVLSLFYTIVTPVFNPMIYSLRNKDVMMALRQWPSKHLSSLKK", "length": 305, "header": "tr|F1MBK2-1|F1MBK2_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR10AG65 PE=3 SV=4 CANONICAL=F1MBK2-1" }, "isoforms": [ { "isoform_ac": "F1MBK2-1", "url": "https://www.uniprot.org/uniprotkb/F1MBK2/entry", "sequence": { "sequence": "MEFVLLDFADVPHLQRFLFGLFLLIYIIILMGNGIIFLITKLDPGLQTPMYFFLGNFSLLEICYVSVTLPRMLTSLWTQRRTISLVACATQMCFILTLGATECFLLAVMAYDRYVAICSPLQYPLVMNYRVCIQLVASSWISGIPIQIGQTCQIFSLPFCGSNLLNHFFCDIPPILKLACGDTFLNEMLVFTVAALFVLVPFLLILVSYGKIISTVLKLPSATSRGKAFSTCSSHLMVVALFFGSGLVTYLRPKTQGSAGTDKVLSLFYTIVTPVFNPMIYSLRNKDVMMALRQWPSKHLSSLKK", "length": 305, "header": "tr|F1MBK2-1|F1MBK2_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR10AG65 PE=3 SV=4 CANONICAL=F1MBK2-1" }, "locus": { "chromosome": "15", "start_pos": 78585930, "end_pos": 78585016, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027652.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027652.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027652.7", "url": "https://www.ensembl.org/id/ENSBTAP00000027652.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:787543", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787543", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MBK2", "url": "https://www.uniprot.org/uniprotkb/F1MBK2" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1MBK2", "url": "https://www.uniprot.org/uniprotkb/F1MBK2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MBK2", "url": "https://www.uniprot.org/uniprotkb/F1MBK2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "F1MBK2", "url": "https://www.uniprot.org/uniprotkb/F1MBK2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MBK2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 305, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MBK2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MBK2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MBK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBK2" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 32, "end_pos": 281, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 56, "end_pos": 58 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"XP_024845976", "name": "transcription factor HIVEP3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845976" }, "gene_names": [ { "name": "HIVEP3", "type": "recommended", "evidence": [ { "id": "F1MBK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBK6" } ] }, { "name": "HIVEP3", "type": "synonym", "evidence": [ { "id": "XP_024845976", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845976" } ] } ], "protein_names": [ { "name": "Transcription factor HIVEP3", "type": "recommended", "evidence": [ { "id": "F1MBK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBK6/entry#names_and_taxonomy" } ] }, { "name": "Kappa-B and V(D)J recombination signal sequences-binding protein", "type": "synonym", "evidence": [ { "id": "F1MBK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBK6/entry#names_and_taxonomy" } ] }, { "name": "Kappa-binding protein 1", "type": "synonym", "evidence": [ { "id": "F1MBK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBK6/entry#names_and_taxonomy" } ] }, { "name": "Zinc finger protein ZAS3", "type": "synonym", "evidence": [ { "id": "F1MBK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBK6/entry#names_and_taxonomy" } ] }, { "name": "transcription factor HIVEP3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024845976", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845976" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MBK6", "url": "https://www.uniprot.org/uniprotkb/F1MBK6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HIVEP3", "url": "https://www.uniprot.org/uniprotkb/F1MBK6", "locus": { "chromosome": "3", "start_pos": 104671256, "end_pos": 104614955, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020745", "url": "https://www.ensembl.org/id/ENSBTAG00000020745" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020745", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020745", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "509866", "url": "https://www.ncbi.nlm.nih.gov/gene/509866", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034729", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034729", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:509866", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509866", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EDRGPPN", "url": "https://omabrowser.org/oma/group/EDRGPPN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MBK6", "url": "https://www.orthodb.org/?gene=F1MBK6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45944", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45944", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45944:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45944:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024845976", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845976", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MBK6", "url": "https://www.uniprot.org/uniprotkb/F1MBK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBK6-1", "url": "https://www.uniprot.org/uniprotkb/F1MBK6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSAPYPGSSTAATQEGPLQELLAPQPFPGPSSVLREGSQEKTGQPQKPPKRSSIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVTPGLHPQSQLLSSHASIIPPEDLPGIPKVFVSRPSQVSLKPTEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPPGLEMERIPGEEFEEPTEGESTDSEEETGTTSTHPTELSPRPKHPLLSSSLYSSGSQGSSHERCSLSQSSSAPSLEDPAPFAEPSSEHPLSHKPEDTHTIKQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNARSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKAKPEQSLLSLQRPPSTTPPVPLLRSHSMPSATCTLSTPHHTFRGSYSFDDHVADSEALSRSSQLFTSHPRMLKRQPAIELPLGGEYSSEEAGPSSKDAASKPADEPEPRESDLTKKTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQLAKPVTVGAHVSSEAEKSQAEHEPWSQMMHYKLGTTLELTPLRKRRKEKSLGDEEEPPSFESTKSQFGSPGPSEAARNLPLESSKSPAEPNKSVPSLEGSAGFQPRTPKPGSSSESGKERRTTSKEISVIQHTSSFEKSDSLEQPGSLEGEDKSAAPFSSPPPAPHGRSAHSLQPRLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESSVSLSGSSRSASFERDDHGKAEATGPSSDTRSKPLGTHMLTVPSHHPHAREMRRSASEQSPNISHSTHMTETRSKSFDYGSLSLTGPSAPTPAAPVASAAPPERRKCFLVRQASLTRPPETEPEATPKGRQESEEPKPSSSKSLAKGALLPVSSAATSHSGHPGGKSQVQDRPALGATPPYTEALQVFPHPIAQLPLQEKPYLPPPVSLFSFQHLLQHEPGQSSEFFPTQAMSSLLSTPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPASSALSSGFFLPLQSQFTLQLPSEVESHVPQIKTSLATLATGTPGLSPSTEYSSDIQLPTVAPPSSCSAPTSAPPLALPASPDTMVSLVVPVRIQTNMPSYGSAMYTTLSQILVTQSQGSSATVALPKFEEPSCKGTSVCGTDAYEVGPRLAGVSEEQSRGFPTPFLRVPVTLPERKGTSLASESVLSLEGSSSTVGGSKRVLSPAGSLELTMETQQQKRVKEEEASKVDEKFELVKPCSVVLSSTEDSKRSEKSYLGSQGQGRRELETLSSLSSDPSDPKEIPPLPQPSLPHVTTSGSEALKEYAQPSGKPHRRGLLPSSVKKEDSKEQADLPPLAPPSSQSLSETSPRPAKLQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPETGRLVPSSSRKPRMTEVRLPSLVSPEGQKEIARVEKEEEKRGKPEEDAPASKRGEPARIKIFEGGYKSNEEYVYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDPFQDSEGREGAEAVAEHQFSDLDDSDSDSDLDEDEDEDEEESQDEPSGPSSEAPPPGPPATLPADSSPVQGPQPTEATRGSSVSEAERSAPSSCSTSSQSILCLPRLAPAPRGPVEKDTVSALSSQALSPRRPWSPSKEAGSHLPLTPKHSLTKSYSSPQRHSPAREPLASAPSPPGSQTGPLPCGSPRLELSPLALHPLGRELPLRARLPPERKGAADPGPPRHSPTRRWSPGQAESPPRSALPGKWALAGPGSPLAAERGPGSGLAPRALYPPAPLPHKLLGRSPAETCTSTWQKAESPSPSCSPAPAHPLFSRPFSAPHDFHGHSPARTENIFSHLPLHSQRLTRAPCPLIPIGGIQMVQARPGAHPILLPGPSAAWVSGFSGGGSDLTGSREAQERGRWSPTESSSASVSPVAKVSKFTLSSELEARDYPTERGRTRGGLGRPPDWEPRAAQVPTEPTPTHSPRTPPETSPRAPPGHRAESRSPHLESPRVPANPAASATPPLDRSSSVGCLAETAARFPARRRNLSGEPRTSQGSPQPSGSGGSGTPPHQPEERGPRST", "length": 2392, "header": "tr|F1MBK6-1|F1MBK6_BOVIN Isoform 1 of Transcription factor HIVEP3 OS=Bos taurus OX=9913 GN=HIVEP3 PE=4 SV=3 CANONICAL=F1MBK6-1" }, "isoforms": [ { "isoform_ac": "F1MBK6-1", "url": "https://www.uniprot.org/uniprotkb/F1MBK6/entry", "sequence": { "sequence": "MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSAPYPGSSTAATQEGPLQELLAPQPFPGPSSVLREGSQEKTGQPQKPPKRSSIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVTPGLHPQSQLLSSHASIIPPEDLPGIPKVFVSRPSQVSLKPTEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPPGLEMERIPGEEFEEPTEGESTDSEEETGTTSTHPTELSPRPKHPLLSSSLYSSGSQGSSHERCSLSQSSSAPSLEDPAPFAEPSSEHPLSHKPEDTHTIKQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNARSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKAKPEQSLLSLQRPPSTTPPVPLLRSHSMPSATCTLSTPHHTFRGSYSFDDHVADSEALSRSSQLFTSHPRMLKRQPAIELPLGGEYSSEEAGPSSKDAASKPADEPEPRESDLTKKTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQLAKPVTVGAHVSSEAEKSQAEHEPWSQMMHYKLGTTLELTPLRKRRKEKSLGDEEEPPSFESTKSQFGSPGPSEAARNLPLESSKSPAEPNKSVPSLEGSAGFQPRTPKPGSSSESGKERRTTSKEISVIQHTSSFEKSDSLEQPGSLEGEDKSAAPFSSPPPAPHGRSAHSLQPRLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESSVSLSGSSRSASFERDDHGKAEATGPSSDTRSKPLGTHMLTVPSHHPHAREMRRSASEQSPNISHSTHMTETRSKSFDYGSLSLTGPSAPTPAAPVASAAPPERRKCFLVRQASLTRPPETEPEATPKGRQESEEPKPSSSKSLAKGALLPVSSAATSHSGHPGGKSQVQDRPALGATPPYTEALQVFPHPIAQLPLQEKPYLPPPVSLFSFQHLLQHEPGQSSEFFPTQAMSSLLSTPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPASSALSSGFFLPLQSQFTLQLPSEVESHVPQIKTSLATLATGTPGLSPSTEYSSDIQLPTVAPPSSCSAPTSAPPLALPASPDTMVSLVVPVRIQTNMPSYGSAMYTTLSQILVTQSQGSSATVALPKFEEPSCKGTSVCGTDAYEVGPRLAGVSEEQSRGFPTPFLRVPVTLPERKGTSLASESVLSLEGSSSTVGGSKRVLSPAGSLELTMETQQQKRVKEEEASKVDEKFELVKPCSVVLSSTEDSKRSEKSYLGSQGQGRRELETLSSLSSDPSDPKEIPPLPQPSLPHVTTSGSEALKEYAQPSGKPHRRGLLPSSVKKEDSKEQADLPPLAPPSSQSLSETSPRPAKLQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPETGRLVPSSSRKPRMTEVRLPSLVSPEGQKEIARVEKEEEKRGKPEEDAPASKRGEPARIKIFEGGYKSNEEYVYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDPFQDSEGREGAEAVAEHQFSDLDDSDSDSDLDEDEDEDEEESQDEPSGPSSEAPPPGPPATLPADSSPVQGPQPTEATRGSSVSEAERSAPSSCSTSSQSILCLPRLAPAPRGPVEKDTVSALSSQALSPRRPWSPSKEAGSHLPLTPKHSLTKSYSSPQRHSPAREPLASAPSPPGSQTGPLPCGSPRLELSPLALHPLGRELPLRARLPPERKGAADPGPPRHSPTRRWSPGQAESPPRSALPGKWALAGPGSPLAAERGPGSGLAPRALYPPAPLPHKLLGRSPAETCTSTWQKAESPSPSCSPAPAHPLFSRPFSAPHDFHGHSPARTENIFSHLPLHSQRLTRAPCPLIPIGGIQMVQARPGAHPILLPGPSAAWVSGFSGGGSDLTGSREAQERGRWSPTESSSASVSPVAKVSKFTLSSELEARDYPTERGRTRGGLGRPPDWEPRAAQVPTEPTPTHSPRTPPETSPRAPPGHRAESRSPHLESPRVPANPAASATPPLDRSSSVGCLAETAARFPARRRNLSGEPRTSQGSPQPSGSGGSGTPPHQPEERGPRST", "length": 2392, "header": "tr|F1MBK6-1|F1MBK6_BOVIN Isoform 1 of Transcription factor HIVEP3 OS=Bos taurus OX=9913 GN=HIVEP3 PE=4 SV=3 CANONICAL=F1MBK6-1" }, "locus": { "chromosome": "3", "start_pos": 104670252, "end_pos": 104615154, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027644.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027644.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027644.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027644.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1027, "start_aa": "Thr", "end_pos": 1027, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1027", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 135, "start_aa": "Thr", "end_pos": 135, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr135", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1903, "start_aa": "Thr", "end_pos": 1903, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1903", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2290, "start_aa": "Thr", "end_pos": 2290, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2290", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2332, "start_aa": "Thr", "end_pos": 2332, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2332", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:509866", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:509866", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A2A884-1", "protein_name": "Transcription factor HIVEP3", "gene_name": "Hivep3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPDQSIKGTKKADGSPRKRLTKGEAIQTSVSSSAPYPGSGTTAPSESATQELLATQPFSGPSQEKTGQQQKPARRPSIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASILPPEELPGIPKVFVPRPSQVSLKPAEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGSSSEMYPPGLEMERIPGEEFEEPTEGESTDSEEETGAASGPSTDVLPKPKHPLLSSSLYSSGSHGSSQERCSLSQSSTGPSLEDPAPFAEASSEHPLSHKPEDTHTIKQKLALRLSERKKLIEEQTFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTSMLASTSTQPLLPLSSEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLTRRSSVESPKSSLYRDSLSSHGEKTKQEQSLLSLQHPPSSTHPVPLLRSHSMPSAACTISTHHHTFRGSYSFDDHVADPEVPSRNTPVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDPTSKPSDEPEPKESDLTKKTKKGFKTKGANYECTICGARYKKRDNYEAHKKYYCSELQITKAHSVGAHEVEKTQAEPEPWSQMMHYKLGATLELTPLRKRRKEKSLGDEEEPPAFGSPGPSETAHNRPLGSTKSPAEASKSAPSLEGPTSFQPRTPKPGAGSEPGKERRTMSKEISVIQHTSSFEKSDPPEQPSGLEEDKPPAQFSSPPPAPHGRSAHSLQPRLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESSISLSGSSRSASFDREDHGKAEAPGPFSDTRSKTLGSHMLTVPSHHPHAREMRRSASEQSPNVPHSSHMTETRSKSFDYGSLSPTGPSLAVPAAPPPPAAPPERRKCFLVRQASLNRPPEAELEAVPKGKQESSEEPAASKPSTKSSVPQISVGTTQGGPSGGKSQMQDRPPLGSSPPYTEALQVFQPLGTQLPPPASLFSLQQLLPQEQEQSSEFFPTQAMAGLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHAADIPFQQPPSFLPMPCPAPSTLSGYFLPLQSQFALQLPGEIESHLPPVKTSLPPLATGPPGPSSSTEYSSDIQLPPVTPQATSPAPTSAPPLALPACPDAMVSLVVPVRIQTHMPSYGSAMYTTLSQILVTQSPGSPASTALTKYEEPSSKSMTVCEADVYEAEPGPSSISKEQNRGYQTPYLRVPERKGTSLSSEGILSLEGCSSTASGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVSTCSVVLTSTEDRKKTEKPHVGGQGRSRREAETLSSLSSDVSDPKELSPLSHSTLSHGTAPGSEALKEYAQPSSKAHRRGLPPMSVKKEDPKEQTDLPPLAPPSSLPLSDTSPKPAKLQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSNSRKPRMTEVHLPSLVSPESQKDPARVEKEEKQGKAEEGTPTSKRGEPARVKIFEGGYKSNEEYIYVRGRGRGRYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLHQDSEGQEGAEAVEEHQFSDLEDSDSDSDLDEDEEEEEEEEESQDELSGPCSEAAPPCLPPTLQENSSPVEGPQAPDSTSDEVPQGSSISEATHLTASSCSTPSRGTQGLPRLGLAPLEKDMSSAPSPKATSPRRPWSPSKEAGSRPSLTRKHSLTKNDSSPQQCSPAREAQASVTSTPGPQMGPGRDLGPHLCGSPRLELSCLTPYPIGREAPAGLERATDTGTPRYSPTRRWSLGQAESPPQTVLPGKWALAGPCSPSADKSGLGLGPVPRALLQPVPLPHTLLSRSPETCTSAWRKTESRSPSAGPAPLFPRPFSAPHDFHGHLPSRSEENLFSHLPLHSQLLSRAPCPLIPIGGIQMVQARPGAQPTVLPGPCAAWVSGFSGGGSDLTGAREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTGRGPGRPPDWEPHRAEAPPGPMGTHSPCSPQLPQGHQVAPSWRGLLGSPHTLANLKASSFPPLDRSSSMDCLAETSTYSPPRSRNLSGEPRTRQGSPELLGRGELRTPLFLPKGSGPPSI", "length": 2348 }, "evidence": [ { "id": "F1MBK6", "url": "https://omabrowser.org/oma/group/F1MBK6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZRB5-1", "protein_name": "Transcription factor HIVEP3", "gene_name": "Hivep3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDPDQSIKGTKKADGSPRKRLTKGEAIQTSVSSSTPYPGSSTTASSEGASQELLAPQPFSGPSVALREGAQEKTGQQQKPPRRPSIEASAHIPKLPQHPLTPAFMSPSKPEHLLEGSTWQLVDPTRPGPSGSFVAPGLHPQSQLLPSHASILPPEDLPGIPKVFVPRPSQVSLKPTEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGSSSEMYPPGLEMERIPGEEFEEPTEGESTDSEEETGATSGPSTDVLPKSKHPLLSSSLYSSGSHGSSQERCSQSSTAPSLEDPTPFAEASSEHPLSHKLEDTHTIKQKLALRLSERKKLIEEQTFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTSMLASTSTQPLLPLSAEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLTRRSSVESPKSSLYRESLSSHGEKTKQEQSLLSLQHPPSSTHPVPLLRSHSMPSAACTISTHHHTFRGSYSFDDHIADPEVPSRSTPVFTSHPRMLKRQPAIELPLGAEYSSEEPGPSSKDPITKPSDEPEPKESDLTKKTKKGLKTKGVNYECTICGARYKKRDNYEAHKKYYCSELQITKAHPAGAHEVEKTQAEPEPWSQMMHYKLGATLELTPLRKRRKEKSLGDEEEPPGFSSPGPSDAAHNLPLESTKSPAEASKSVPTLEGPTSFQPRTPKPGSGSEPGKERRTMSKEISVIQHTSSFEKSDPPEQPGSLEEDKPLAPFSSPPPAPHGRSAHSLQPRLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESSISLSGSSRSASFDREDHGKAETPGPLSDTRSKTLGTHMLTVPSHHPHAREMRRSASEQSPNVPHSSHMTETRSKSFDYGSLSPTGPSVAVPAAPPPPAAPPERRKCFLVRQASLSRPPEAELEATPKGKQESSEEPSASKPSTKSSMAQISVATIQGGLSGSKSQMQDRPPLGSSPPYTEALQVFQPLGTQLPPPVSLFSLQQLLPQEQEQSSEFFPTQAMAGLLSSPYSVPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHAADIPFQQPPSFLPMPCPAPSTLSGYFLPLQSQFALQLPGEIESHLPSIKTSLPPLATGPPGPSSSTEYSSDIQLPPVTPQATSPAPTSASPLALPACPDAMVSLVVPVRIQTHMPSYGSAMYTTLSQILVTQSPGSSTSMALTKYEEPSSKSMTVCGADVYEAEPGPSSISKEQSRGFQTPYLRVPERKGTALSSEGILSLEGCSSTASGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVSTCNVVLTSTEDRKKTEKPHVGSQGRSRRETETLSCLSSDVSDPKELSPLSQSTLSHGTAPGSEALKEYAQPSSKAHRRCLPPLSVKKEDPKEQTDLPPLAPPSSLPLSDTSPRPAKLQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSNSRKPRMTEVHLPSMVSLESQKDPARVEKEEKAEEGTPTSKRGEPTRVKIFEGGYKSNEEYIYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCRHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLLQDSEGREGSEAVEEHQFSDLEDSDSDSDLDEDEEEEEEEEEESQDELSRPSSEAAPLCLPATLQEDSSLIRGPQPPDATSDAAPRGSSISEATRLTASSCSTPSQGTQGLPRLGLAPLEKGTSSALSPKATSPRRPWSPSKEAGSRPSLTRKHSLTKTDSSPQRCSPARAQASVASTPGPQTGPGRDLSPHLCGSPRPELSCLTPYPIGREVPAGLESATVTGTPRCSPTRRRSLGRAESSPPHTVLPGTWALGGPCSPSVDKYGLGLGPVPRALLQPVPLPHTLLSRSPETCASAWTESRSPSAGPAPLSSRPSSAPHDFHGHLPSRSEENLFSHLPLHSQHLNRTPCPLIPIGGIQMVQARPGAHPTLLSGPCAAWVSGFSGGGSDLTGAREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTSRGPGRPPAWEPHRAEAPAETMGTHSPCPPQLPQGHPLAPSWRGLLESPHALANLKASSFPPLDRSSSMDCLAETSTCFPPRSRNLSGEPRTRPDSPELLGSGELRTPLFLSKDSGPPSI", "length": 2349 }, "evidence": [ { "id": "F1MBK6", "url": "https://omabrowser.org/oma/group/F1MBK6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HCN7-1", "protein_name": "Transcription factor HIVEP3", "gene_name": "Hivep3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDPEQSIKCTKKADGSPRKRLTKGEAIQTSVSSSAPYPGSGTTAPSESATQELLTPQPFSGPSVVLREGSQEKTGQQQQQPPRRPSIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQGQLLPSHASILPPEDLPGIPKVFVPRPSQVSLKPAEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGSSSEMYPPGLEMERIPGEEFEEPTEGESTDSEEETGATSGPPTEVLPKSKHPLLSSGLYSSGSQSSSQERCSLSQSSTAPSLEDSSPFAEASSEHSLTHKPEDTHTIKQKLALRLSERKKLIEEQTFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTSMLASTSTQPLLPLSAEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLTRRSSVESPKSSLYRESLSSHGEKTKPEQSLLSLQHPPSSAHPVPLLRSHSMPSAACTISTPHHTFRGSYSFDDHTADPEAPSRSSPMFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDPTSKPPDEPESKESDLTKKTKKGLKTKGVSYECNICGARYKKRDNYEAHKKYYCSELQITKAHSAGAHDVEKTQAEPEPWSQMMHYKLGATLELTPLRKRRKEKSLGDEEEPPTFGSPGPSDPARSNLPLESTKSPAEPSKSVPSVEGPTSFQPRTPKPGTGSEPGKERRTMSKEISVIQHTSSFEKSDPLEQPSSLEEDKPLAQFSSPPPAPHGRSAHSLQPRLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSAPLSRSPSQESNISLSGSSRTASFDREDHGKADLPGSSSDTRSKPLGTHMLTVPSHHPHAREMRRSASEQSPNVPHSSHMTETRSKSFDYGSLSPTGPSVAVPPPPAAPPERRKCFLVRQASLSRPPEAELEATPKGKQESSEEPSASKPSTKSSVPQISMATTQGGPSGGKSQMQDRPPLGSSPPYTEALQVFRPPGTQVPPPVSLFSLQHLLPQEQEQPSEFFPTQAMANLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHPTDIPFRQPPSFLPMPCPASSTLSGYFLPLQSQFALQLPGEIESHLPPIKTTLAPLAAGSSGPSGSTEYSSDIQLPLVTPSVTSPVPTSAPTLALPACPDAMVSLVVPVRIQTHMPSYGSAMYTTLSQILVTQSQGSSASMALAKYEGPSSKGMTVCVADVYEAGPGPSSISKEQSRGFQTPYLRVPERKGSSLSSEGILSLEGGSSTAGGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVSTCSVVLTSTEGRQRTEKPYVGSQGQSRREAETLSSSLPSDPSDPKEVSPLSHPTLPHGTAPGSEALKEYAQPSSKAHRRGLPPLSIKKEDPKEQPDLPPLAPPSSLPLSDTSPKPAKFQEGTDSKKVLQFPGLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLLSTESQKDSARVEKEEKQGKAEEGTPTSKRGEPARVKIFEGGYKSNEEYIYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLFQDSEGQEGTEAVEEHQFSDLEDSDSDSDLDEDEEEDEEESQDELSRPSSEAAPLCLPTTLQEDSSPIQGPQPPVTTSDEVPQGSSISEVTHLAASSCYMPSRGTPGLPQLGLTPVETDMSSALSSKAVSPRRSWSPSKETGSRPSLTRKHTLSKNDLSPQRCSPAREAQASVMSTPAPQMGPGRDIGPNLCGSPRLELSPLTPHPIRREVSPWAPLPHELKSATDTGAPRYSPTRRWSLGQAESLPQSVLPGKWALAGPCSPSVGKCSLGLGPVPQALLQPVPLPHTLLSRSPEMCSSAWQKTETRSPSCSAGPVPVFPRPFSAPHDFHGHLPSRSEENLFSHLPLHSQHLSRAPCPLIPIGGIQMVQARPGAHPTLLPGACAAWVSGFSGGGSDLTGAREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTGRGPGRPPDWEPQRAEAPAEPMGTHSPCSPQLPRGHQAAPSWSALLESSHTLANRKASSFPPMDRSSSMDCLAEASSHFPARSRNLSGEPRTRQGSPELLHSGEPRTPLFLPKDSGPPST", "length": 2361 }, "evidence": [ { "id": "F1MBK6", "url": "https://omabrowser.org/oma/group/F1MBK6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q5T1R4-1", "protein_name": "Transcription factor HIVEP3", "gene_name": "HIVEP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAATQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASVHISQLPQHPLTPAFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGVPKVFVPRPSQVSLKPTEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPGEEFEEPTEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQSLEDPPPFVEPSSEHPLSHKPEDTHTIKQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPSLVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREPLSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRSHSMPSAACTISTPHHPFRGSYSFDDHITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPKESELTKKTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTSPEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKSLGDEEEPPAFESTKSQFGSPGPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEISVIQHTSSFEKSDSLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVPEILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMAQSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLGTHMLTVPSHHPHAREMRRSASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVAPPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPSAKSSLSQISSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLFSFQHLVQHEPGQSPEFFSTQAMSSLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLHLPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQIKTSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVPVRVQTNMPSYGSAMYTTLSQILVTQSQGSSATVALPKFEEPPSKGTTVCGADVHEVGPGPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAGSLELTMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRRELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEALKEYPQPSGKPHRRGLTPLSVKKEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLNYIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAPHPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEERRGEPEEDAPASQRGEPARIKIFEGGYKSNEEYVYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLFQDSEGREGSEAVEEHQFSDLEDSDSDSDLDEDEDEDEEESQDELSRPSSEAPPPGPPHALRADSSPILGPQPPDAPASGTEATRGSSVSEAERLTASSCSMSSQSMPGLPWLGPAPLGSVEKDTGSALSYKPVSPRRPWSPSKEAGSRPPLARKHSLTKNDSSPQRCSPAREPQASAPSPPGLHVDPGRGMGALPCGSPRLQLSPLTLCPLGRELAPRAHVLSKLEGTTDPGLPRYSPTRRWSPGQAESPPRSAPPGKWALAGPGSPSAGEHGPGLGLDPRVLFPPAPLPHKLLSRSPETCASPWQKAESRSPSCSPGPAHPLSSRPFSALHDFHGHILARTEENIFSHLPLHSQHLTRAPCPLIPIGGIQMVQARPGAHPTLLPGPTAAWVSGFSGGGSDLTGAREAQERGRWSPTESSSASVSPVAKVSKFTLSSELEGGDYPKERERTGGGPGRPPDWTPHGTGAPAEPTPTHSPCTPPDTLPRPPQGRRAAQSWSPRLESPRAPTNPEPSATPPLDRSSSVGCLAEASARFPARTRNLSGEPRTRQDSPKPSGSGEPRAHPHQPEDRVPPNA", "length": 2406 }, "evidence": [ { "id": "F1MBK6", "url": "https://omabrowser.org/oma/group/F1MBK6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GH84-1", "protein_name": "HIVEP zinc finger 3", "gene_name": "HIVEP3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDPEQSQKSTKKAEESPRKRLPKGEAFQASISSAATYQGSSASSQGTPLRDLISQQHFSGSLPIPREESQEKTGHQKQPKPSSFEHPPHVSQLQQHALSPAFMSPGKPEHVLEGPTWQLVDPVRPGPSGSFPSPGLHAHHGQILPSHSPIIPGEDMPSVQKVYIPRPSQVPLKQAEEVHKKEKKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGERPYPCIPCGFSFKTKSNLYKHRKSHAHRIKAGLASGIGAEMYPSSLEMERIGGEDFEEPTEGESTDSEEETGAMSGHPAELSPRQKHTLLSSSLLSAGSQGSSHDRCSLSHSSMSQSLEDSSQFAEPPSDQALSHKSEDTHTIKQKLALRLSERKKVIDEQAFLSPGSKGSTESGYFSRSESAEQQISPPNTNAKSYAEIIFGKCGRIGQRTAMLSTNTTQGFPHLSTEEKPSMVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSIESPKSAAYREPFQFDIKSGSSSQLDASKALTSHGEKMKPEQSLLSLQQSHSATETVPLLRSHSMPSAACTISSPHTFRGSYSFDDHIMEPEVLSRSQAFSSHPRMLKRQPAIELPLGVEYVTEEVSSASKETVSKPPEEPETKESDLTKKSRKGPKVKGFMYECNVCGARYKKRDNYEAHKKYYCSELQLSKPRSSTSHTSSETEKNVMDPETWPQVMHYKLGSTLELTPLRKRRKEKSLGDDEDPPAFELSDTPSSSTGPGAQFANLASSDVALNLTRESMKSPADPGKSAPSDVSASFHSRNTKLVSSTEGKERRTTSKEISVIQHTSSFEKSDSIEQVSGLEGEEKPTPQYPSQPTTQHSRPHHSLQPKLVRQPNIQVPEILVTEEPDRPETEPEPPPKEPEKTEEFQWPQRSQTLSQLPAEKLPPKKKRLRLAEMAQSSGESSFESVSLTRSPSQESSVSHGSSHSVSFDREDHSKTEPGSQPPESHSKPPGVGSHMLMVPSHHHHHSREMRRSASEQTPNVSHVSQMSETRSKSFDYGSLSSTPASTPGPSTSSAPQERRKCFLVRQASLTRHPEHEPDPAPAGRPEAEDPVPSLSKSPSTSLPHQPPSSSPLPSHGTYPSDKSQPKDSPQPAYTQPYTEALQVFHPVPQLTLHEKHFLSPQVSIFPYQPLLPQPGQPAELFAAHTMSDLLSAQLTVPQLPPSIFQTPPLPLQQTLLHPGPLHLAPPLIPHPTEVPFRQHPSFLPVHYPSSSPISSAFFLPLQSQFALQLPEAGGHLPQLKSSLFPAAGTSSLSPCTEYSSDTRLYPLTRTTSPSVPVSTAQLIVPTRSDPVVSLVVPVRIQTNMPSYGSAMYTTLSQILVTQSQCSSSSIVLPKFDDCQPKGTLVCSADVHGLGFDLAQMITEEQRIFQSPYLRVPLPLPERKGCIPLTSPADSVLGLEGGPSTVGGSKRMLSPAGSLELTMETQQQKRVKEEEVSEAEEKLEVVKPPSAIEEGKKQDKAHFLTESQGRVEVETPPSLSLEQSELKETPSTLQQAVSRSGSPSFEALEEYQQPAGKQPLGKAPLQSVKKEDSKEPVEQPPPSPPSPAPLSEVPSSAMKSREGTDMKKVLQFPSLHTTTNVSWCYLNYIKPNHIQQVDRRSSVYASWCISLYNPNLPGISTKVALSLLRSKQKVSRETYTMATAPRPEAGRLVPSSSRKPKMTEVHLPSLLSNEGRKEITRAEKEEDKRGKPEEEAVVTKRGEPVRIKIFEGGYKSNEEYVYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVCKYCNFAFKTKGNLTKHMKSKAHSKKCQEMGVLVSSLVDLEAEEGTSEDLFQDSEGREGSEPIEEHQFSDLEESDDDDDNEDDEDEEEEESQDEPPLKLPEAKHPTPLMHSSGGSPTSQEEGTETASSLAQETASSSQKVGEGQQGSSCGLETRWSADSSDIAVCHSILSLHRPALTSTEQLASAERESVTRPPMSLAMELSASKDTSPRKRWSPSQDSSRAGGSSRPMLARKHLLTKNETSPKRFSPTGEMSPLRCLSPGRGLSPCPRVSPRREASPLRCVSPRLELSPSRHLSPRRELSPRAYLPPEGEASSPSREMPSGRYLSLKKTLPPSCSEAPRYPSPGKEDAPGTSRSAADDKIQSSYQAQHGILSSMPLPHRFFGKNVQLYESKLKIEPRSPPRSPGTMQPICFRPLQAPHELHTHSRGEENVFSHLPLHSQQLARTPYPMIPIGGIQMVQARPSTHPSSVMSLPGGHFSPGGSSFEEPWVPREPSSASVSPVAKVSKYTLSPEPTSSECLEEKMRTSELKQKPDPEEYRVKVFAEPSPAEQPGRSASPANPSTTRQPSPKPSTSGDDPLTNPGEKQCGSSSSPLESPHCTFTSELPSPPPPRSLQPSGEPHRAPRSPRAEPTGVGHAQTEADDSTGSA", "length": 2448 }, "evidence": [ { "id": "F1MBK6", "url": "https://omabrowser.org/oma/group/F1MBK6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MBK6", "url": "https://www.uniprot.org/uniprotkb/F1MBK6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MBK6", "url": "https://www.uniprot.org/uniprotkb/F1MBK6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MBK6", "url": "https://www.uniprot.org/uniprotkb/F1MBK6" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MBK6", "url": "https://www.uniprot.org/uniprotkb/F1MBK6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MBK6", "url": "https://www.uniprot.org/uniprotkb/F1MBK6" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1MBK6", "url": "https://www.uniprot.org/uniprotkb/F1MBK6" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1MBK6", "url": "https://www.uniprot.org/uniprotkb/F1MBK6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1603, "end_pos": 1605, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1796, "end_pos": 1798, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2357, "end_pos": 2359, "annotation": "n_glycosylation_sequon" }, { "start_pos": 761, "end_pos": 763, "annotation": "n_glycosylation_sequon" }, { "start_pos": 998, "end_pos": 1000, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MBK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBK6" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 192, "end_pos": 219, "start_aa": "Tyr", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MBK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBK6" }, { "id": "PS51811", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51811" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CCHC HIVEP-type", "eco_id": "ECO_0000259", "start_pos": 640, "end_pos": 670, "start_aa": "Gly", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 135, 1027, 1903, 2290, 2332 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1603, "end_pos": 1605 }, { "start_pos": 1796, "end_pos": 1798 }, { "start_pos": 2357, "end_pos": 2359 }, { "start_pos": 761, "end_pos": 763 }, { "start_pos": 998, "end_pos": 1000 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 5 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 5 }, { "field": "exact_o_linked_sites", "count": 5 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", 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"sequence": { "sequence": "MTFPAHPGDRVNKINERVRSRTKVPVPDQVLQLGSKTLKPKRTLSSYGIDKETTIHLTLKVVKPSDEELPLVLVEPGEGGQRHELQVRRSSSVAQVKEMIKMRTAIPPKKQIVNCNGKKLEDGKIMGDYGIKKGHLLFLTYPCIGG", "length": 146, "header": "tr|A0ABI0NQY6-1|A0ABI0NQY6_BOVIN Computationally mapped isoform of Ubiquitin D OS=Bos taurus OX=9913 GN=UBD PE=3 SV=1 CANONICAL=F1MBR4-1" }, "locus": { "chromosome": "23", "start_pos": 29119456, "end_pos": 29119019, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151577.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151577.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107711.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107711.1" } ] } }, { "isoform_ac": "F1MBR4-1", "url": "https://www.uniprot.org/uniprotkb/F1MBR4/entry", "sequence": { "sequence": "MATVVDVTVHSEKWKPMTFPAHPGDRVNKINERVRSRTKVPVPDQVLQLGSKTLKPKRTLSSYGIDKETTIHLTLKVVKPSDEELPLVLVEPGEGGQRHELQVRRSSSVAQVKEMIKMRTAIPPKKQIVNCNGKKLEDGKIMGDYGIKKGHLLFLTYPCIGG", "length": 162, "header": "tr|F1MBR4-1|F1MBR4_BOVIN Isoform 1 of Ubiquitin D OS=Bos taurus OX=9913 GN=UBD PE=3 SV=3 CANONICAL=F1MBR4-1" }, "locus": { "chromosome": "23", "start_pos": 29119456, "end_pos": 29117720, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012533.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012533.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012533.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012533.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7F151-1", "protein_name": "Ubiquitin D", "gene_name": "Ubd", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASCICIVHSEKWPSMTFDATENDKVKKINEHIRSKTKVSVQDQVLLLGPKTLKPQRTLSSYGINKETTIHLTLKVVKPSDEELHLFLVESTNEGQRHLLPVRRSSSVAQVKEMIEGVTGVTPKTQIVTCNGKRLEDGKTMADYNIRRGSLLFLTGHCIGG", "length": 161 }, "evidence": [ { "id": "F1MBR4", "url": "https://omabrowser.org/oma/group/F1MBR4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O15205-1", "protein_name": "Ubiquitin D", "gene_name": "UBD", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPNASCLCVHVRSEEWDLMTFDANPYDSVKKIKEHVRSKTKVPVQDQVLLLGSKILKPRRSLSSYGIDKEKTIHLTLKVVKPSDEELPLFLVESGDEAKRHLLQVRRSSSVAQVKAMIETKTGIIPETQIVTCNGKRLEDGKMMADYGIRKGNLLFLACYCIGG", "length": 165 }, "evidence": [ { "id": "F1MBR4", "url": "https://omabrowser.org/oma/group/F1MBR4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P63072-1", "protein_name": "Ubiquitin D", "gene_name": "Ubd", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASVRTCVVRSDQWRLMTFETTENDKVKKINEHIRSQTKVSVQDQILLLDSKILKPHRKLSSYGIDKETTIHLTLKVVKPSDEELPLFLVESKNEGQRHLLRVRRSSSVAQVKEMIESVTSVIPKKQVVNCNGKKLEDGKIMADYNIKSGSLLFLTTHCTGG", "length": 162 }, "evidence": [ { "id": "F1MBR4", "url": "https://omabrowser.org/oma/group/F1MBR4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q921A3-1", "protein_name": "Ubiquitin D", "gene_name": "Ubd", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASCVCVVRSEQWPLMTFDTTMSDKVKKINEHIRSQTKVSVQDQILLLDSKILKPHRALSSYGIDKENTIHLTLKVVKPSDEELPLSLVESGDEGQRHLLRVRRSSSVAQVKEMIENVTAVPPKKQIVNCNGKRLEDGKIMADYNIKSGSLLFLTAHCIGG", "length": 161 }, "evidence": [ { "id": "F1MBR4", "url": "https://omabrowser.org/oma/group/F1MBR4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9SHE7-1", "protein_name": "Ubiquitin-NEDD8-like protein RUB1", "gene_name": "RUB1", "tax_id": 3702, "organism": 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"go_terms": [ { "name": "response to tumor necrosis factor", "id": "GO:0034612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034612", "evidence": [ { "database": "UniProtKB", "id": "F1MBR4", "url": "https://www.uniprot.org/uniprotkb/F1MBR4" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "F1MBR4", "url": "https://www.uniprot.org/uniprotkb/F1MBR4" } ], "pmid": "" }, { "name": "positive regulation of canonical NF-kappaB signal transduction", "id": "GO:0043123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043123", "evidence": [ { "database": "UniProtKB", "id": "F1MBR4", "url": "https://www.uniprot.org/uniprotkb/F1MBR4" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "F1MBR4", "url": "https://www.uniprot.org/uniprotkb/F1MBR4" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "F1MBR4", "url": "https://www.uniprot.org/uniprotkb/F1MBR4" } ], "pmid": "" }, { "name": "response to type II interferon", "id": "GO:0034341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034341", "evidence": [ { "database": "UniProtKB", "id": "F1MBR4", "url": "https://www.uniprot.org/uniprotkb/F1MBR4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "proteasome binding", "id": "GO:0070628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070628", "evidence": [ { "database": "UniProtKB", "id": "F1MBR4", "url": "https://www.uniprot.org/uniprotkb/F1MBR4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MBR4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 162, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MBR4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MBR4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MBR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBR4" }, { "id": "PS50053", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50053" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 80, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": 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} ] } ], "protein_names": [ { "name": "Dpy-19 like 2", "type": "synonym", "evidence": [ { "id": "F1MBU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBU8/entry#names_and_taxonomy" } ] }, { "name": "probable C-mannosyltransferase DPY19L2-like", "type": "synonym", "evidence": [ { "id": "NP_001193711", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193711" } ] }, { "name": "probable C-mannosyltransferase DPY19L2", "type": "synonym", "evidence": [ { "id": "NP_001193711", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193711" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MBU8", "url": "https://www.uniprot.org/uniprotkb/F1MBU8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DPY19L2", "url": "https://www.uniprot.org/uniprotkb/F1MBU8", "locus": { "chromosome": "4", "start_pos": 61941431, "end_pos": 61850757, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032650", "url": "https://www.ensembl.org/id/ENSBTAG00000032650" } ] } } ], "crossref": [ { "id": "F1MBU8", "url": "https://alphafold.ebi.ac.uk/entry/F1MBU8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032650", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032650", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "524676", "url": "https://www.ncbi.nlm.nih.gov/gene/524676", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524676", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524676", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DPLQGDY", "url": "https://omabrowser.org/oma/group/DPLQGDY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MBU8", "url": "https://www.orthodb.org/?gene=F1MBU8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31488", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31488", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31488:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31488:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10034", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10034", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001193711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193711", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MBU8", "url": "https://www.uniprot.org/uniprotkb/F1MBU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBU8-1", "url": "https://www.uniprot.org/uniprotkb/F1MBU8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGQTRSKLRGAASEPSHFLRSTQSRRRRRATGSGERELEKEPKEEVKRPELPLRTRRGNLTRGARKYSPQRIRNLKTQNCVPVEMVRRTDLLNDRFPFLSSLLEQLSDKAQLLQRRQVSGKGAFGIAAFVAILHWVHLITLFENDRHFSHLSALEREMTFRTEMGLYYSYFKTIVEAPSFLQGLWMIMNDRLTEYPLVINTVKRFHLYPEVILAFCYRTFVGIMNLFGLETKTCWNVTRIEPLNEVQSCEGLGDPACFYVGVIFILNGIMMGLFFMYGAYLSGTQLGGIITVLCYFFNHGEATRVMWTPPLRESFSYPFLVLQMYILTVILRTTNNSRRHFIALCLSNVAFMLPWQFAQFILFTQIASLFPMYVVGYIEPNKFQKIIHANMISVLLCFVFMFGNPMYLSSYYSSSLIITLVIILKRNKIQRFGVSELHFWVIQGSAWFFGTIILKFLTSKILGVSDHIRLSDLIAARILRYTDFDTLIYTCAPEFDFMETATPVRYSKTLLLPIVVVITYVIFKKAFRDILCVLCANTYLRKQLLEHGEIIFHTLQLFAFTPLAILIMRLKLFLTPHMCVMASLICSRRLFGWIFCRVRFMPVILSLVTVMSIQGYANLHNQWSIIGEFNNLPQEELIQWIKYNTRPDAVFAGAMPTMASVKLSTLHPIVNHPHYEDADLRARTKIVYSAYSRKSAKEVRDKLVELHVNYYILEEAWCVVRTKPGCSMLEIWDVEDPSNSANPPLCSVLLKDARPYFTTVFQNSMYRVLKVN", "length": 773, "header": "tr|F1MBU8-1|F1MBU8_BOVIN Isoform 1 of Dpy-19 like 2 OS=Bos taurus OX=9913 GN=DPY19L2 PE=3 SV=2 CANONICAL=F1MBU8-1" }, "isoforms": [ { "isoform_ac": "F1MBU8-1", "url": "https://www.uniprot.org/uniprotkb/F1MBU8/entry", "sequence": { "sequence": "MVGQTRSKLRGAASEPSHFLRSTQSRRRRRATGSGERELEKEPKEEVKRPELPLRTRRGNLTRGARKYSPQRIRNLKTQNCVPVEMVRRTDLLNDRFPFLSSLLEQLSDKAQLLQRRQVSGKGAFGIAAFVAILHWVHLITLFENDRHFSHLSALEREMTFRTEMGLYYSYFKTIVEAPSFLQGLWMIMNDRLTEYPLVINTVKRFHLYPEVILAFCYRTFVGIMNLFGLETKTCWNVTRIEPLNEVQSCEGLGDPACFYVGVIFILNGIMMGLFFMYGAYLSGTQLGGIITVLCYFFNHGEATRVMWTPPLRESFSYPFLVLQMYILTVILRTTNNSRRHFIALCLSNVAFMLPWQFAQFILFTQIASLFPMYVVGYIEPNKFQKIIHANMISVLLCFVFMFGNPMYLSSYYSSSLIITLVIILKRNKIQRFGVSELHFWVIQGSAWFFGTIILKFLTSKILGVSDHIRLSDLIAARILRYTDFDTLIYTCAPEFDFMETATPVRYSKTLLLPIVVVITYVIFKKAFRDILCVLCANTYLRKQLLEHGEIIFHTLQLFAFTPLAILIMRLKLFLTPHMCVMASLICSRRLFGWIFCRVRFMPVILSLVTVMSIQGYANLHNQWSIIGEFNNLPQEELIQWIKYNTRPDAVFAGAMPTMASVKLSTLHPIVNHPHYEDADLRARTKIVYSAYSRKSAKEVRDKLVELHVNYYILEEAWCVVRTKPGCSMLEIWDVEDPSNSANPPLCSVLLKDARPYFTTVFQNSMYRVLKVN", "length": 773, "header": "tr|F1MBU8-1|F1MBU8_BOVIN Isoform 1 of Dpy-19 like 2 OS=Bos taurus OX=9913 GN=DPY19L2 PE=3 SV=2 CANONICAL=F1MBU8-1" }, "locus": { "chromosome": "4", "start_pos": 61940798, "end_pos": 61850902, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046335.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046335.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043644.2", "url": "https://www.ensembl.org/id/ENSBTAP00000043644.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524676", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524676", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P0CW70-1", "protein_name": "Probable C-mannosyltransferase DPY19L2", "gene_name": "Dpy19l2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVGPTRSKLREGSSDRPQSSCTGQARRRWSAATMEPQQERSAPQERTKWSLLQHFLLGGRKLPSGARNYAARRIQSLNAQNYFQLEEVAKLLLLNRFQFLFTLLDHFREKVQALQMHRFSHRTLFGLAIFVGILHWLHLITLFENDHHFSHLSSLEREMTFRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLVINTVKRFHLYPEVVIAYWYRTIIGIMNLFGIETKTCWNVTRMEPLNEVQSCEGLGDPACFYIGVIFILNGLMMGLFFIYSTYLSGSQLGGLITVACYFFNHGEATRVMWTPPLRESFSYPFLVLQMYILTIILRTSTVHKKHYMALCFSNVAFMLPWQFAQFILFTQIASLFPMYVVGYIEPSKFQKIIYVNMSSVALCFILMFGNSMYLSSYYSSCLLVTWAIMQKKSKIQKLGGTELQFWLIQGCFWWCGTIILKFLTSKICGVSDHIRLSDLIAARILRYTDFDTLIYTCAPEFDFMEQATPLRYIKTLLLPLILVITYLIFKKIVRDIMCVLYTNTYVRKQLLDNAELIFHTLQLLAFTGLAILIMRLKLFLTPHMCIMASLICSQRLFGWLFCRIHFENVVFGILTMMSIQGCANLHNQWSIMGEFTNLPQEELIHWIKHSTRPDAVFAGAMPTMASIKLSTLRPIVNHPHYEDADLRARTKIVYSVYSRKSAVEVRNNLLKLHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLCSILLKDSRPYFTTVFQNSMYRVLKIN", "length": 773 }, "evidence": [ { "id": "F1MBU8", "url": "https://omabrowser.org/oma/group/F1MBU8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6NUT2-1", "protein_name": "Probable C-mannosyltransferase DPY19L2", "gene_name": "DPY19L2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRKQGVSSKRLQSSGRSQSKGRRGASLAREPEVEEEMEKSALGGGKLPRGSWRSSPGRIQSLKERKGLELEVVAKTFLLGPFQFVRNSLAQLREKVQELQARRFSSRTTLGIAVFVAILHWLHLVTLFENDRHFSHLSSLEREMTFRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLIINAIKRFHLYPEVIIASWYCTFMGIMNLFGLETKTCWNVTRIEPLNEVQSCEGLGDPACFYVGVIFILNGLMMGLFFMYGAYLSGTQLGGLITVLCFFFNHGEATRVMWTPPLRESFSYPFLVLQMCILTLILRTSSNDRRPFIALCLSNVAFMLPWQFAQFILFTQIASLFPMYVVGYIEPSKFQKIIYMNMISVTLSFILMFGNSMYLSSYYSSSLLMTWAIILKRNEIQKLGVSKLNFWLIQGSAWWCGTIILKFLTSKILGVSDHIRLSDLIAARILRYTDFDTLIYTCAPEFDFMEKATPLRYTKTLLLPVVMVITCFIFKKTVRDISYVLATNIYLRKQLLEHSELAFHTLQLLVFTALAILIMRLKMFLTPHMCVMASLICSRQLFGWLFRRVRFEKVIFGILTVMSIQGYANLRNQWSIIGEFNNLPQEELLQWIKYSTTSDAVFAGAMPTMASIKLSTLHPIVNHPHYEDADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLCSVLLEDARPYFTTVFQNSVYRVLKVN", "length": 758 }, "evidence": [ { "id": "F1MBU8", "url": "https://omabrowser.org/oma/group/F1MBU8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VWR8-1", "protein_name": "C-mannosyltransferase dpy-19 homolog", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MREPNLYVILSHALIGCGFFFLYVQHVRVIFETRTNIQQLNQLEREALLRREDALYYAFYKQLAEGPDFWHGYEQLKNVTDIEYPHSVNVLQRFYVLPELVTAYFFHVVRSGFNPMVQPMQFYLEFVWLMGGVTLLVLYLYGTLLSENIFGGIYGVISYLMFHSFVAKIYERPLARENFAFPFIFLQMFYLCICIGRIIHRQRHTSRMFMIFAMSLFTACALLSWQFSTFIFTTQILIMMTSWNASALPTALVNAFVLDYSLSHLLGHALAFVMSHGNSQLLLTWQLSISLFLFLITMVRQLRHVRSRRLGHAQDLLNGDLFSLKFLMLTLLLASSVQTTLIELFNRAGVVSVTEGDQQHFFDICAHWALQVNVGFVAHLSACNPQYARVAWSELWQLVKTMIVKPYCMYGVVMLAMFFRRWRKSGAPVSALTEEQRERARKYVLEDFIEEHFVSMSDMSSKETEKQLYKCFRLLKSCDYDYERYKRAQASLRKEQPPARDDFMQDIKRLRAQINRNSVKQRKERAQETKEAATDGASTPTEEEDKDPEAESESKKKNQEPGSGETETESAADPTETPPSRSADNEEEEEEHSATAAGCGSNSSGHRQRKRSSSRRSSVVPTANAQILNMHYVYSFLQMLVFTLIGLAVRKLFFLSFTQGCVIAPTVCSKLWYHRQRNIFWSVSLAVFLLSMFDPGMVNIREEYFPTRYSKSGDDLDSMLEWIKLNTERDAVFAGPVDIIGTVHLTTKRPIVNHAHLEMRQIAERTEHVYSVYSRQQSSDIYNQCAQLKIQYLIISLDECTNEVRDDCDLLAIWDDKQPAYQKYPQFCHELLHKNVPSFLKVFANDHYGIIKMFSQSVQINLKHNKMPEMSI", "length": 872 }, "evidence": [ { "id": "F1MBU8", "url": "https://omabrowser.org/oma/group/F1MBU8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "F1MBU8", "url": "https://www.uniprot.org/uniprotkb/F1MBU8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "mannosyltransferase activity", "id": "GO:0000030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000030", "evidence": [ { "database": "UniProtKB", "id": "F1MBU8", "url": "https://www.uniprot.org/uniprotkb/F1MBU8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nuclear inner membrane", "id": "GO:0005637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005637", "evidence": [ { "database": "UniProtKB", "id": "F1MBU8", "url": "https://www.uniprot.org/uniprotkb/F1MBU8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" }, { "start_pos": 336, "end_pos": 338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 60, "end_pos": 62, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MBU8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 773, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MBU8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MBU8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 237, "end_pos": 239 }, { "start_pos": 336, "end_pos": 338 }, { "start_pos": 60, "end_pos": 62 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MBW8-1", "uniprot_ac": "F1MBW8", "uniprot_id": "F1MBW8_BOVIN", "mass": { "chemical_mass": 35842.0, "monoisotopic_mass": 35842.0 }, "refseq": {}, "gene_names": [ { "name": "OR11H6", "type": "recommended", "evidence": [ { "id": "F1MBW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBW8" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1MBW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBW8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": 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"cd15913", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15913", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QREMQNF", "url": "https://omabrowser.org/oma/group/QREMQNF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24242", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24242", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24242:SF90", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24242:SF90", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-381753", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381753", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MBW8", "url": "https://www.uniprot.org/uniprotkb/F1MBW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBW8-1", "url": "https://www.uniprot.org/uniprotkb/F1MBW8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "ITFFFSQKVVLLTASTVTEFILLGFPGCQEEMQMFFFSLILVVYLLTLLGNGAVVCAVKWDRRLHTPMYIFLGNFAFLEIWYVSSTVPSMLINILSDTKTISFTGCFIQFYFFFSLGTTECFFLSVMAYDRYLAICCPLHYPSIMTGKFCVVLVCVCWVSGFLCYPVPIVLISQLPFCGPNIIDHFVCDPGPLFALACIPAPSTELICYTFNSVIIFGPFLSILGSYTLVLRAVLRFPSHAGRTKAFSTCGSHLMVVSLFYGTLMVMYVSPTSGNPAGMQKIITLVYSAVTPLLNPLIYSLRNKDMKDALKKVLGLRINQN", "length": 321, "header": "tr|F1MBW8-1|F1MBW8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR11H6 PE=3 SV=4 CANONICAL=F1MBW8-1" }, "isoforms": [ { "isoform_ac": "F1MBW8-1", "url": "https://www.uniprot.org/uniprotkb/F1MBW8/entry", "sequence": { "sequence": "ITFFFSQKVVLLTASTVTEFILLGFPGCQEEMQMFFFSLILVVYLLTLLGNGAVVCAVKWDRRLHTPMYIFLGNFAFLEIWYVSSTVPSMLINILSDTKTISFTGCFIQFYFFFSLGTTECFFLSVMAYDRYLAICCPLHYPSIMTGKFCVVLVCVCWVSGFLCYPVPIVLISQLPFCGPNIIDHFVCDPGPLFALACIPAPSTELICYTFNSVIIFGPFLSILGSYTLVLRAVLRFPSHAGRTKAFSTCGSHLMVVSLFYGTLMVMYVSPTSGNPAGMQKIITLVYSAVTPLLNPLIYSLRNKDMKDALKKVLGLRINQN", "length": 321, "header": "tr|F1MBW8-1|F1MBW8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR11H6 PE=3 SV=4 CANONICAL=F1MBW8-1" }, "locus": { "chromosome": "10", "start_pos": 26895807, "end_pos": 26886951, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054084.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054084.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050569.4", "url": "https://www.ensembl.org/id/ENSBTAP00000050569.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 272, "start_aa": "Thr", "end_pos": 272, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr272", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-381753", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381753", "resource": "Reactome", "description": "Olfactory Signaling Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A2I3BQ89-1", "protein_name": "Olfactory receptor", "gene_name": "Or11h6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGMRMEFAFGSKNSSIHFVTEFILLGFSNQGEMQSFFFCSILILYLLTLLGNGTIVCAVRWDQRLHTPMYIFLGNFAFLEIWYVSSTIPNMLVNILSENKTISFSACFLQFYFFFSLGTTECFFLSAMAYDRYLAICRPLHYPSIMTRKFCVILICICWVSGFLCYPVPIVLISQLPFCGPNIIDHFVCDPGPLFALSCVPAPSTELLCYTFNSMIIFGPFFCILGSYTLVLRAVFRVPSGAGRTKAFSTCGSHLVVVSLFYGTLMVMYVSPTSGNPAGMQKIVTLIYSALTPLLNPLIYTLRNKEMKNALKKLLKLTTIQN", "length": 322 }, "evidence": [ { "id": "F1MBW8", "url": "https://omabrowser.org/oma/group/F1MBW8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1M3L9-1", "protein_name": "Olfactory receptor", "gene_name": "Or11h6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAMRTESALGSKNNTIHFVTEFILLGFSIQGEMRSFFFSSVLVLYLLTLLGNGAIVCAVRWDQKLHTPMYIFLGNFAFLEIWYVSSTIPNMLVNILSESKTISFSACFFQFYFFFSLGTTECFFLSAMAYDRYLAICRPLHYPSIMTRKFCVILICICWVSGFLCYPVPIILISQLPFCGPNIIDHFVCDPGPLFALSCVPAPSTELLCYTFNSMIIFGPFCSILGSYTLVLRAVLRVPSGAGRTKAFSTCGSHLVVVSLFYGTLMVMYVSPTSGNPAGMQKIVTLIYSALTPLINPLIYSLRNKDMKNALKKVLKLTTIQN", "length": 322 }, "evidence": [ { "id": "F1MBW8", "url": "https://omabrowser.org/oma/group/F1MBW8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NGC7-1", "protein_name": "Olfactory receptor 11H6", "gene_name": "OR11H6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFFIIHSLVTSVFLTALGPQNRTMHFVTEFVLLGFHGQREMQSCFFSFILVLYLLTLLGNGAIVCAVKLDRRLHTPMYILLGNFAFLEIWYISSTVPNMLVNILSEIKTISFSGCFLQFYFFFSLGTTECFFLSVMAYDRYLAICRPLHYPSIMTGKFCIILVCVCWVGGFLCYPVPIVLISQLPFCGPNIIDHLVCDPGPLFALACISAPSTELICYTFNSMIIFGPFLSILGSYTLVIRAVLCIPSGAGRTKAFSTCGSHLMVVSLFYGTLMVMYVSPTSGNPAGMQKIITLVYTAMTPFLNPLIYSLRNKDMKDALKRVLGLTVSQN", "length": 330 }, "evidence": [ { "id": "F1MBW8", "url": "https://omabrowser.org/oma/group/F1MBW8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MBW8", "url": "https://www.uniprot.org/uniprotkb/F1MBW8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1MBW8", "url": "https://www.uniprot.org/uniprotkb/F1MBW8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MBW8", "url": "https://www.uniprot.org/uniprotkb/F1MBW8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MBW8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 321, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MBW8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MBW8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MBW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBW8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 299, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 272 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MBX3-1", "uniprot_ac": "F1MBX3", "uniprot_id": "F1MBX3_BOVIN", "mass": { "chemical_mass": 45424.0, "monoisotopic_mass": 45424.0 }, "refseq": { "ac": "NP_001178302", "name": "steroid hormone receptor ERR1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178302" }, "gene_names": [ { "name": "ESRRA", "type": "recommended", "evidence": [ { "id": "F1MBX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBX3" } ] }, { "name": "ESRRA", "type": "synonym", "evidence": [ { "id": "NP_001178302", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178302" } ] } ], "protein_names": [ { "name": "Steroid hormone receptor ERR1", "type": "recommended", "evidence": [ { "id": "F1MBX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBX3/entry#names_and_taxonomy" } ] }, { "name": "Estrogen-related receptor alpha", "type": "synonym", "evidence": [ { "id": "F1MBX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBX3/entry#names_and_taxonomy" } ] }, { "name": "Nuclear receptor subfamily 3 group B member 1", "type": "synonym", "evidence": [ { "id": "F1MBX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBX3/entry#names_and_taxonomy" } ] }, { "name": "steroid hormone receptor ERR1", "type": "synonym", "evidence": [ { "id": "NP_001178302", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178302" } ] } ], "function": [ { "annotation": "ERalpha, is only expressed in the caruncle of the placenta.", "evidence": [ { "database": "RefSeq", "id": "NP_001178302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178302" }, { "database": "PubMed", "id": "15772903", "url": "https://glygen.org/publication/PubMed/15772903" } ] }, { "annotation": "The results identify TGFB1 and ESRRA as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.", "evidence": [ { "database": "RefSeq", "id": "NP_001178302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178302" }, { "database": "PubMed", "id": "24767884", "url": "https://glygen.org/publication/PubMed/24767884" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MBX3", "url": "https://www.uniprot.org/uniprotkb/F1MBX3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ESRRA", "url": "https://www.uniprot.org/uniprotkb/F1MBX3", "locus": { "chromosome": "29", "start_pos": 42611802, "end_pos": 42603598, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008645", "url": "https://www.ensembl.org/id/ENSBTAG00000008645" } ] } } ], "crossref": [ { "id": "F1MBX3", "url": "https://alphafold.ebi.ac.uk/entry/F1MBX3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008645", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008645", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06946", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06946", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07170", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07170", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507834", "url": "https://www.ncbi.nlm.nih.gov/gene/507834", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001628", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001628", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001723", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001723", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013088", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013088", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027289", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027289", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:507834", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507834", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ASNVCEI", "url": "https://omabrowser.org/oma/group/ASNVCEI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MBX3", "url": "https://www.orthodb.org/?gene=F1MBX3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48092", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48092", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00104", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00104", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00105", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00105", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-383280", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001178302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178302", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NYZ5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NYZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBX3", "url": "https://www.uniprot.org/uniprotkb/F1MBX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MBX3-1", "url": "https://www.uniprot.org/uniprotkb/F1MBX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGDGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD", "length": 422, "header": "tr|F1MBX3-1|F1MBX3_BOVIN Isoform 1 of Steroid hormone receptor ERR1 OS=Bos taurus OX=9913 GN=ESRRA PE=3 SV=2 CANONICAL=F1MBX3-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NYZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NYZ5/entry", "sequence": { "sequence": "MCGRVCKEVEPRQRVCLGPEGKMCQVTSAMSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGDGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD", "length": 451, "header": "tr|A0ABI0NYZ5-1|A0ABI0NYZ5_BOVIN Computationally mapped isoform of Steroid hormone receptor ERR1 OS=Bos taurus OX=9913 GN=ESRRA PE=3 SV=1 CANONICAL=F1MBX3-1" }, "locus": { "chromosome": "29", "start_pos": 42611000, "end_pos": 42604448, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000147837.1", "url": "https://www.ensembl.org/id/ENSBTAT00000147837.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107654.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107654.1" } ] } }, { "isoform_ac": "F1MBX3-1", "url": "https://www.uniprot.org/uniprotkb/F1MBX3/entry", "sequence": { "sequence": "MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGDGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD", "length": 422, "header": "tr|F1MBX3-1|F1MBX3_BOVIN Isoform 1 of Steroid hormone receptor ERR1 OS=Bos taurus OX=9913 GN=ESRRA PE=3 SV=2 CANONICAL=F1MBX3-1" }, "locus": { "chromosome": "29", "start_pos": 42611000, "end_pos": 42605333, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036417.6", "url": "https://www.ensembl.org/id/ENSBTAT00000036417.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036275.4", "url": "https://www.ensembl.org/id/ENSBTAP00000036275.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Estrogen receptor beta (ERbeta) is expressed differently from ERalpha in bovine placentomes.", "journal": "Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association", "date": "2005-02", "authors": "Schuler G, Teichmann U, Taubert A, Failing K, Hoffmann B", "evidence": [ { "database": "RefSeq", "id": "NP_001178302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178302" } ], "reference": [ { "type": "PubMed", "id": "15772903", "url": "https://glygen.org/publication/PubMed/15772903" } ] }, { "title": "Transcriptional regulators transforming growth factor-\u03b21 and estrogen-related receptor-\u03b1 identified as putative mediators of calf rumen epithelial tissue development and function during weaning.", "journal": "Journal of dairy science", "date": "2014-07", "authors": "Connor E E, Baldwin R L, Walker M P, Ellis S E, Li C, Kahl S, Chung H, Li R W", "evidence": [ { "database": "RefSeq", "id": "NP_001178302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178302" } ], "reference": [ { "type": "PubMed", "id": "24767884", "url": "https://glygen.org/publication/PubMed/24767884" } ] } ], "pathway": [ { "id": "bta:507834", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:507834", "resource": "KEGG Pathway" }, { "id": "R-BTA-383280", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-383280", "resource": "Reactome", "description": "Nuclear Receptor transcription pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MUC5-1", "protein_name": "Steroid hormone receptor ERR1", "gene_name": "Esrra", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVTLAPGPAPARCLPGHKEEEDGEGAGSGEQGSGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPASPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGDLGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD", "length": 422 }, "evidence": [ { "id": "F1MBX3", "url": "https://omabrowser.org/oma/group/F1MBX3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1RQP2-1", "protein_name": "Steroid hormone receptor ERR1", "gene_name": "ESRRA", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRTASPAPAVSWRKRSRKRPRCPFVSYKPPAAPPCEGTRRGGAARPEEAAEEGPPAAPGSPRRSRPLGPHACPPALREPQVTSAMSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGSGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD", "length": 506 }, "evidence": [ { "id": "F1MBX3", "url": "https://omabrowser.org/oma/group/F1MBX3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O08580-1", "protein_name": "Steroid hormone receptor ERR1", "gene_name": "Esrra", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVTLASGPAPARCLPGHKEEEDGEGAGSGEQGSGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPASPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGDLGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD", "length": 422 }, "evidence": [ { "id": "F1MBX3", "url": "https://omabrowser.org/oma/group/F1MBX3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P11474-1", "protein_name": "Steroid hormone receptor ERR1", "gene_name": "ESRRA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD", "length": 423 }, "evidence": [ { "id": "F1MBX3", "url": "https://omabrowser.org/oma/group/F1MBX3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5QJV7-1", "protein_name": "Steroid hormone receptor ERR1", "gene_name": "Esrra", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVTLASGPAPARCLPGHKEEEDGEGAGSGEQGSGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPASPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGDLGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD", "length": 422 }, "evidence": [ { "id": "F1MBX3", "url": "https://omabrowser.org/oma/group/F1MBX3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "estrogen response element binding", "id": "GO:0034056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034056", "evidence": [ { "database": "UniProtKB", "id": "F1MBX3", "url": "https://www.uniprot.org/uniprotkb/F1MBX3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MBX3", "url": "https://www.uniprot.org/uniprotkb/F1MBX3" } ], "pmid": "" }, { "name": "nuclear steroid receptor activity", "id": "GO:0003707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003707", "evidence": [ { "database": "UniProtKB", "id": "F1MBX3", "url": "https://www.uniprot.org/uniprotkb/F1MBX3" } ], "pmid": "" }, { "name": "steroid binding", "id": "GO:0005496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005496", "evidence": [ { "database": "UniProtKB", "id": "F1MBX3", "url": "https://www.uniprot.org/uniprotkb/F1MBX3" } ], "pmid": "" }, { "name": "nuclear receptor activity", "id": "GO:0004879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004879", "evidence": [ { "database": "UniProtKB", "id": "F1MBX3", "url": "https://www.uniprot.org/uniprotkb/F1MBX3" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "F1MBX3", "url": "https://www.uniprot.org/uniprotkb/F1MBX3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MBX3", "url": "https://www.uniprot.org/uniprotkb/F1MBX3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MBX3", "url": "https://www.uniprot.org/uniprotkb/F1MBX3" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1MBX3", "url": "https://www.uniprot.org/uniprotkb/F1MBX3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MBX3", "url": "https://www.uniprot.org/uniprotkb/F1MBX3" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MBX3", "url": "https://www.uniprot.org/uniprotkb/F1MBX3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MBX3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 422, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MBX3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MBX3" } ], "lectin_list": 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377734" }, "gene_names": [ { "name": "OR10AL41", "type": "recommended", "evidence": [ { "id": "F1MBY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBY4" } ] }, { "name": "OR10AL41", "type": "synonym", "evidence": [ { "id": "NP_001377734", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377734" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1MBY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBY4/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 10 subfamily AL member 41", "type": "synonym", "evidence": [ { "id": "NP_001377734", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377734" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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"MSSQSSILVDFRPLATSFTGKYGSIQYCVRAVLERPQVPDQSVRRELQVVSHVDVNTPPLLTPMLKTQEKMVGCWLFTSGPVSLSVKIERKGYCNGEAIPIYAEIENCSSRLVVPKAAIFQTQTYLASGKTKTVRHMVANVRGNHIGSGSTDTWNGKMLKIPPVTPSILDCCIIRVYIHIPGAKKLMLELPLVIGTIPYSGFGRRNSSMASQFSMDMCWLALALPEQPEAPPNYADVVSEEEFSRHIPPYPQPSACDGEACYSMFACIQEFRFQPPPLYSESHAQLFCLQPVGPTNRAHF", "length": 300 }, "evidence": [ { "id": "F1MBY7", "url": "https://omabrowser.org/oma/group/F1MBY7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8NCT1-1", "protein_name": "Arrestin domain-containing protein 4", "gene_name": "ARRDC4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGGEAGCAAAVGAEGRVKSLGLVFEDERKGCYSSGETVAGHVLLEASEPVALRALRLEAQGRATAAWGPSTCPRASASTAALAVFSEVEYLNVRLSLREPPAGEGIILLQPGKHEFPFRFQLPSEPLVTSFTGKYGSIQYCVRAVLERPKVPDQSVKRELQVVSHVDVNTPALLTPVLKTQEKMVGCWFFTSGPVSLSAKIERKGYCNGEAIPIYAEIENCSSRLIVPKAAIFQTQTYLASGKTKTIRHMVANVRGNHIASGSTDTWNGKTLKIPPVTPSILDCCIIRVDYSLAVYIHIPGAKKLMLELPLVIGTIPYNGFGSRNSSIASQFSMDMSWLTLTLPEQPEAPPNYADVVSEEEFSRHIPPYPQPPNCEGEVCCPVFACIQEFRFQPPPLYSEVDPHPSDVEESQPVSFIL", "length": 418 }, "evidence": [ { "id": "F1MBY7", "url": "https://omabrowser.org/oma/group/F1MBY7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MBY7", "url": "https://www.uniprot.org/uniprotkb/F1MBY7" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F1MBY7", "url": "https://www.uniprot.org/uniprotkb/F1MBY7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MBY7", "url": "https://www.uniprot.org/uniprotkb/F1MBY7" } ], "pmid": "" }, { "name": "extracellular vesicle", "id": "GO:1903561", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903561", "evidence": [ { "database": "UniProtKB", "id": "F1MBY7", "url": "https://www.uniprot.org/uniprotkb/F1MBY7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1MBY7", "url": "https://www.uniprot.org/uniprotkb/F1MBY7" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "F1MBY7", "url": "https://www.uniprot.org/uniprotkb/F1MBY7" } ], "pmid": "" }, { "name": "extracellular vesicle biogenesis", "id": "GO:0140112", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140112", "evidence": [ { "database": "UniProtKB", "id": "F1MBY7", "url": "https://www.uniprot.org/uniprotkb/F1MBY7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "F1MBY7", "url": "https://www.uniprot.org/uniprotkb/F1MBY7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" }, { "start_pos": 320, "end_pos": 322, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MBY7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 413, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MBY7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MBY7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MBY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBY7" }, { "id": "SM01017", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01017" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Arrestin C-terminal-like", "eco_id": "ECO_0000259", "start_pos": 186, "end_pos": 313, "start_aa": "Thr", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 215, "end_pos": 217 }, { "start_pos": 320, "end_pos": 322 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MC10-1", "uniprot_ac": "F1MC10", "uniprot_id": "F1MC10_BOVIN", "mass": { "chemical_mass": 50727.0, "monoisotopic_mass": 50727.0 }, "refseq": { "ac": "XP_002696070", "name": "endoplasmic reticulum protein SC65", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696070" }, "gene_names": [ { "name": "P3H4", "type": "recommended", "evidence": [ { "id": "F1MC10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC10" } ] }, { "name": "P3H4", "type": "synonym", "evidence": [ { "id": "XP_002696070", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696070" } ] } ], "protein_names": [ { "name": "Endoplasmic reticulum protein SC65", "type": "recommended", "evidence": [ { "id": "F1MC10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC10/entry#names_and_taxonomy" } ] }, { "name": "Leprecan-like protein 4", "type": "synonym", "evidence": [ { "id": "F1MC10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC10/entry#names_and_taxonomy" } ] }, { "name": "Prolyl 3-hydroxylase family member 4", "type": "synonym", "evidence": [ { "id": "F1MC10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC10/entry#names_and_taxonomy" } ] }, { "name": "Synaptonemal complex protein SC65", "type": "synonym", "evidence": [ { "id": "F1MC10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC10/entry#names_and_taxonomy" } ] }, { "name": "endoplasmic reticulum protein SC65", "type": "synonym", "evidence": [ { "id": "XP_002696070", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696070" } ] } ], "function": [ { "annotation": "Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly.", "evidence": [ { "database": "UniProtKB", "id": "F1MC10", "url": "https://www.uniprot.org/uniprotkb/F1MC10#function" }, { "database": "UniProtKB", "id": "ARBA00057860", "url": "https://www.uniprot.org/uniprotkb/ARBA00057860#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MC10", "url": "https://www.uniprot.org/uniprotkb/F1MC10" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "P3H4", "url": "https://www.uniprot.org/uniprotkb/F1MC10", "locus": { "chromosome": "19", "start_pos": 41997949, "end_pos": 42005150, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025752", "url": "https://www.ensembl.org/id/ENSBTAG00000025752" } ] } } ], "crossref": [ { "id": "F1MC10", "url": "https://alphafold.ebi.ac.uk/entry/F1MC10", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025752", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025752", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "788823", "url": "https://www.ncbi.nlm.nih.gov/gene/788823", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052284", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052284", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056585", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056585", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:788823", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788823", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EAFCGRN", "url": "https://omabrowser.org/oma/group/EAFCGRN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MC10", "url": "https://www.orthodb.org/?gene=F1MC10", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13986", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13986", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13986:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13986:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23557", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23557", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002696070", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696070", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MC10", "url": "https://www.uniprot.org/uniprotkb/F1MC10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC10-1", "url": "https://www.uniprot.org/uniprotkb/F1MC10-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARTAWGLLWLLLGSAGAQYEKYSFRGFPPEDLMPLAAAYGHALEQYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPAPPAAAPPGPALPGPDGGDEWARELRLFGHVLERAACLRRCKRSLPAFQVPYPPRQLLRDFQSRLPYQYLHYAQFKANRLEKAVAAAYTFLQRNPKHELTAKYLSYYRGLLDAADEPLTDLEAQPYEAVFLRAVKLYNSGDFRGSTEDMERALAEYLAVFARCLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCEANLTPNVGGYFVEKFVATMYHYLQFAYYKLNDVRQAARSAASYMLFDPEDNVMQQNLVYYRFHRARWGLEEEDFQPREEARLYHNQTAELRELLDFAHMYLQSDDEMELEETEPPMEPEKPPSDAEFEGEGDYEESIYADWWQEPDAKGDEAEAEPEPELP", "length": 442, "header": "tr|F1MC10-1|F1MC10_BOVIN Isoform 1 of Endoplasmic reticulum protein SC65 OS=Bos taurus OX=9913 GN=P3H4 PE=3 SV=3 CANONICAL=F1MC10-1" }, "isoforms": [ { "isoform_ac": "F1MC10-1", "url": "https://www.uniprot.org/uniprotkb/F1MC10/entry", "sequence": { "sequence": "MARTAWGLLWLLLGSAGAQYEKYSFRGFPPEDLMPLAAAYGHALEQYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPAPPAAAPPGPALPGPDGGDEWARELRLFGHVLERAACLRRCKRSLPAFQVPYPPRQLLRDFQSRLPYQYLHYAQFKANRLEKAVAAAYTFLQRNPKHELTAKYLSYYRGLLDAADEPLTDLEAQPYEAVFLRAVKLYNSGDFRGSTEDMERALAEYLAVFARCLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCEANLTPNVGGYFVEKFVATMYHYLQFAYYKLNDVRQAARSAASYMLFDPEDNVMQQNLVYYRFHRARWGLEEEDFQPREEARLYHNQTAELRELLDFAHMYLQSDDEMELEETEPPMEPEKPPSDAEFEGEGDYEESIYADWWQEPDAKGDEAEAEPEPELP", "length": 442, "header": "tr|F1MC10-1|F1MC10_BOVIN Isoform 1 of Endoplasmic reticulum protein SC65 OS=Bos taurus OX=9913 GN=P3H4 PE=3 SV=3 CANONICAL=F1MC10-1" }, "locus": { "chromosome": "19", "start_pos": 42004951, "end_pos": 41998597, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036396.6", "url": "https://www.ensembl.org/id/ENSBTAT00000036396.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036255.5", "url": "https://www.ensembl.org/id/ENSBTAP00000036255.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:788823", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:788823", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4INE3-1", "protein_name": "Endoplasmic reticulum protein SC65", "gene_name": "p3h4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MVDTKTYFFVFLSIAYSSSFVKAQYEKYSFKSFPMNDLMPLESAYGHALEMYATQDWKQSLTYLELSLRLHRLLRDSEAFCSSNCSTVCSEYENNSTGTTFRIMEHIILRAACLKRCKTKFPVFSKSYPKRETLAAFEKRIPYRYLQFVYYQMNELERAVSAAHTYLQRNPGDPLLSRSVNYYKSLFDLEEYLIDHEEKSYEALFLKAVKLYNSGDFSSSVRDMELTAAEYFTKYQMCLLSCEGSYDVQEFKDFYPALAELYFEVLQCKVKCEENLMPNVGGYFVDKFVATMFHYMQFAYFKLNDVRNAALCAATYMLFDRDDQVMQQNMAYYRFYREQWGLQDEHFKPRPEALKYYNLITKLRELLEFANNYLQTDDEDSVSADEAVLSNPADEEFEGIGDYEESFLAEWWQEPKTKGDTGEPVE", "length": 426 }, "evidence": [ { "id": "F1MC10", "url": "https://omabrowser.org/oma/group/F1MC10/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1S0L4-1", "protein_name": "Endoplasmic reticulum protein SC65", "gene_name": "P3H4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARTAWGLLWLLLGSAGAQYEKYSFRGFPPEDLMPLAAAYGHALEQYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPAPPSAATPGPAPPDPDGGHEDEWARELQLFGHVLERAACLRRCKRSLPAFQVPYPPRQLLRDFQSRLPYQYLHYAQFKANRLEKAVAAAYTFLQRNPKHELTAKYLNYYRGLLDAAEEPLTDLEAQPYEAVFLRAVKLYNSGDFRGSTEDMERALAEYLAVFARCLAGCEGAHEQVDFKDFYPSIADLFAESLQCKVDCETNLTPNVGGYFVEKFVATMYHYLQFAYYKLNDVRQAARSAASYMLFDPADSVMQQNLVYYRFHRARWGLEEEDFQPREEAVLYHNQTAELRELLDFAHMYLQSDDEMELEEPEPPTEPEEPPSDAEFEGEGDYEESIYADWWQEPDAKGDEAEAEPEPELP", "length": 444 }, "evidence": [ { "id": "F1MC10", "url": "https://omabrowser.org/oma/group/F1MC10/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q64375-1", "protein_name": "Endoplasmic reticulum protein SC65", "gene_name": "P3h4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARAAWGLLWLLLGSAGAQYEKYSFRGFPPEDLMPLATAYGHALEQYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPATSQPRPAPGPDGDNEGDGEDWARELRLFGHVLERAACLRRCKRTLPAFQVPYPSRQLLRDFQNRLPYQYLHYAHFKANRLEKAVAAAYTFLQRNPKHELTAKYLNYYRGMLDIGDESLTDLEAQPYEAVFLQAVKLYNSGDFRSSTEHMERALADYMTVFARCLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCEANLTPNVGGFFVDKFVATMYHYLQFAYYKLNDVHQAARSAASYMLFDPKDSVMQQNLVYYRFHRARWGLEEEDFQPREEAVLYHNQTSELRELLDFTHMYLQSDDEMELEETESLPEPEKPLSDAEFEGEGDYEEGLYADWWQEPDAKGDEDEAEPEPELA", "length": 443 }, "evidence": [ { "id": "F1MC10", "url": "https://omabrowser.org/oma/group/F1MC10/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8K2B0-1", "protein_name": "Endoplasmic reticulum protein SC65", "gene_name": "P3h4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARGAWGLLWLLLGSAGAQYEKYSFRGFPPEDLMPLATAYGHALEQYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPATSQPRPASGPDGDHDGDGEDWARELRLFGHVLERAACLRRCKKTLPAFQVPYPPRQLLRDFQSRLPYQYLHYAHFKANRLEKAVAAAYTFLQRNPKHELTAKYLNYYRGMLDIGDESLTDLEAQPYEAVFLRAVKLYNSGDFRSSTEDMERALAEYMTVFARCLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCETNLTPNVGGFFVDKFVATMYHYLQFAYYKLNDVRQAARSAASYMLFDPKDSVMQQNLVYYRFHRARWGLEDEDFQPREEAMLYHNQTSELRELLDFTHMYLQSDDEMELEETESLPEPEEPLSDAEFEGEGDYEEGLYADWWQEPEAKGDEAEAEPEPELT", "length": 443 }, "evidence": [ { "id": "F1MC10", "url": "https://omabrowser.org/oma/group/F1MC10/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92791-1", "protein_name": "Endoplasmic reticulum protein SC65", "gene_name": "P3H4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARVAWGLLWLLLGSAGAQYEKYSFRGFPPEDLMPLAAAYGHALEQYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPAPAAKPDPDGGRADEWACELRLFGRVLERAACLRRCKRTLPAFQVPYPPRQLLRDFQSRLPYQYLHYALFKANRLEKAVAAAYTFLQRNPKHELTAKYLNYYQGMLDVADESLTDLEAQPYEAVFLRAVKLYNSGDFRSSTEDMERALSEYLAVFARCLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCEANLTPNVGGYFVDKFVATMYHYLQFAYYKLNDVRQAARSAASYMLFDPKDSVMQQNLVYYRFHRARWGLEEEDFQPREEAMLYHNQTAELRELLEFTHMYLQSDDEMELEETEPPLEPEDALSDAEFEGEGDYEEGMYADWWQEPDAKGDEAEAEPEPELA", "length": 437 }, "evidence": [ { "id": "F1MC10", "url": "https://omabrowser.org/oma/group/F1MC10/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GH52-1", "protein_name": "Endoplasmic reticulum protein SC65", "gene_name": "P3H4", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGCAALALLLLLLAAGPCAAQYEQYSVRGFPAAALEPLQRAYARALAQYAGAQWAESARALEASLRLHRLLRDSEAHCHRRCAEGGSAEEPPAEGDRAEWEWERELQLFGRLLRRAGCLRACKRGLPVFQLRYPPAQTLRDFQRRLPYQYLHYALFKSNKIEKAVSAAHTFLQKNPKHEMTLKYLNYYRTMVDVDEYLVDLEAQPYEPIFVRSVKLYNNGDFRSSAADMEQALAEYYKAYEDCLAGCEGAYELQEFKDFYPAIADHFVSVLRCKVGCESELTPNVGGYFVEKFVATMYHYLQFAYYKLNDVRDAVRSVSSYMLFDPDDAVMQQNLVYYRFHRERWHLQEEDFEPRPEAVRYYNRTAAQKKMLEFARQYLQADDEMEVDDGEEPDLRDLPSDGEFEGEGDYEEGFFAEWWQEPNTKGDKADEETL", "length": 434 }, "evidence": [ { "id": "F1MC10", "url": "https://omabrowser.org/oma/group/F1MC10/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1MC10", "url": "https://www.uniprot.org/uniprotkb/F1MC10" } ], "pmid": "" }, { "name": "catalytic complex", "id": "GO:1902494", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902494", "evidence": [ { "database": "UniProtKB", "id": "F1MC10", "url": "https://www.uniprot.org/uniprotkb/F1MC10" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "collagen fibril organization", "id": "GO:0030199", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030199", "evidence": [ { "database": "UniProtKB", "id": "F1MC10", "url": "https://www.uniprot.org/uniprotkb/F1MC10" } ], "pmid": "" }, { "name": "bone remodeling", "id": "GO:0046849", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046849", "evidence": [ { "database": "UniProtKB", "id": "F1MC10", "url": "https://www.uniprot.org/uniprotkb/F1MC10" } ], "pmid": "" }, { "name": "collagen biosynthetic process", "id": "GO:0032964", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032964", "evidence": [ { "database": "UniProtKB", "id": "F1MC10", "url": "https://www.uniprot.org/uniprotkb/F1MC10" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 366, "end_pos": 368, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MC10-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 442, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MC10-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MC10" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MC10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC10" }, { "id": "PF23557", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23557" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Leprecan-like alpha-helical", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 345, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 283, "end_pos": 285 }, { "start_pos": 366, "end_pos": 368 }, { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MC26-1", "uniprot_ac": "F1MC26", "uniprot_id": "F1MC26_BOVIN", "mass": { "chemical_mass": 109675.0, "monoisotopic_mass": 109675.0 }, "refseq": { "ac": "XP_024837787", "name": "TBC1 domain family member 2B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837787" }, "gene_names": [ { "name": "TBC1D2B", "type": "recommended", "evidence": [ { "id": "F1MC26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC26" } ] }, { "name": "TBC1D2B", "type": "synonym", "evidence": [ { "id": "XP_024837787", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837787" } ] } ], "protein_names": [ { "name": "TBC1 domain family member 2B", "type": "synonym", "evidence": [ { "id": "XP_024837787", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837787" }, { "id": "F1MC26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC26/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MC26", "url": "https://www.uniprot.org/uniprotkb/F1MC26" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBC1D2B", "url": "https://www.uniprot.org/uniprotkb/F1MC26", "locus": { "chromosome": "21", "start_pos": 30373215, "end_pos": 30461455, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000012022", "url": "https://www.ensembl.org/id/ENSBTAG00000012022" } ] } } ], "crossref": [ { "id": "F1MC26", "url": "https://alphafold.ebi.ac.uk/entry/F1MC26", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012022", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012022", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01265", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01265", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535927", "url": "https://www.ncbi.nlm.nih.gov/gene/535927", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050302", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050302", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535927", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535927", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MC26", "url": "https://www.orthodb.org/?gene=F1MC26", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47219", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47219", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47219:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47219:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024837787", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837787", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MC26", "url": "https://www.uniprot.org/uniprotkb/F1MC26", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC26-1", "url": "https://www.uniprot.org/uniprotkb/F1MC26-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGPAARGEEGSGGEGAAPGTAAEPGAGPGREPARLCGYLQKLSGKGPLRGYRNRWFVFDARRCYLYYFKTPQDALPLGHLDIADACFSYSGPDEAAEPGAEPPAHFQVHSAGAVTVLKAPNRQLMTYWLQELQQKRWEYCNSLDVVKWDSRTSPTPGDFSQGLVARDNTDLINLHSNASAEKARNVLAVEAAPGELVGEQAANQPAPGPPNSINFSFKQWGTELRNSMSSFRPGKGHNDSRRSVFYTNEEWELLEPSPKELEESMVQEERKKQAPEGNKGITGSGFPFDFGRIPYKGKRPLKEMIGSYKNRHSIGDPSPEVPSGSGSASKPASEMQLLVQNQQEELERLRKDLASQKELVRLLQQTVRSSQYDKYFTSSRLCDGVPQDTLGLLHQKDEQILGLTNQLERFNQEKDSLQQEVRMLKSKVGELSERLGMLMETIQAKDEVIMKLSRQLSECEGSASSPTCIPGSPVAAPAGRDQLELDWLKDNLQGYKTQNKFLNKEILELAALRRNAERRERDLMAKYSSLEAKLCQIESKYLILLQEMKTPVCSEEQGPARDVIAQLLEDALQVESPEHPEQAFIKPHLVSEYDIYGFKTVPEDDEEEKLVARVRALDLKTLHLTENQEVSTGVKWENHFASTVNREMACSPELKNLVRAGIPHEHRSKVWKWCVDRHIKKFKDSTQPGYFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHAHFEQYKVDYTLITFNWFLVVFVDSVVSDVLFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTRTILDARKLIGISFGDLNPFPLRQIRNRRAYHLEKVRLELTELEAIREDFLRERDTSPDKGELVSDEEEDT", "length": 963, "header": "tr|F1MC26-1|F1MC26_BOVIN Isoform 1 of TBC1 domain family member 2B OS=Bos taurus OX=9913 GN=TBC1D2B PE=4 SV=3 CANONICAL=F1MC26-1" }, "isoforms": [ { "isoform_ac": "F1MC26-1", "url": "https://www.uniprot.org/uniprotkb/F1MC26/entry", "sequence": { "sequence": 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"MESAAVSAAPDATLDPPLEQLRHLAGELRQLLPGVRVGEAQETTKEFDREAFWRRFNEAAVTVSREATTLTVAFSRLPLPSPQETQRFCEQVHAAIKAIIGVYYLFPKDQGITLRKLVRSATLDIVDDMAQLVEALYINPAQSSPENLISYNSVWDACQHVPQIPKDNKAAALSVLTKSVDLVKDAHEEMEQAVEECDPYCGLLNDIEEDSSDNHVDEDILGCPNNRDSYWSEEDQELIIPCLALARASKACLKKIRLSVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPVCSLTVRINSAKLASVLKKALEITKASHVTPQPEDSWIPLLINAVDHCMNRIKELTQNEVES", "length": 358, "header": "tr|F1MC78-1|F1MC78_BOVIN Isoform 1 of Cyclin-D1-binding protein 1 OS=Bos taurus OX=9913 GN=CCNDBP1 PE=3 SV=2 CANONICAL=F1MC78-1" }, "isoforms": [ { "isoform_ac": "F1MC78-1", "url": "https://www.uniprot.org/uniprotkb/F1MC78/entry", "sequence": { "sequence": "MESAAVSAAPDATLDPPLEQLRHLAGELRQLLPGVRVGEAQETTKEFDREAFWRRFNEAAVTVSREATTLTVAFSRLPLPSPQETQRFCEQVHAAIKAIIGVYYLFPKDQGITLRKLVRSATLDIVDDMAQLVEALYINPAQSSPENLISYNSVWDACQHVPQIPKDNKAAALSVLTKSVDLVKDAHEEMEQAVEECDPYCGLLNDIEEDSSDNHVDEDILGCPNNRDSYWSEEDQELIIPCLALARASKACLKKIRLSVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPVCSLTVRINSAKLASVLKKALEITKASHVTPQPEDSWIPLLINAVDHCMNRIKELTQNEVES", "length": 358, "header": "tr|F1MC78-1|F1MC78_BOVIN Isoform 1 of Cyclin-D1-binding protein 1 OS=Bos taurus OX=9913 GN=CCNDBP1 PE=3 SV=2 CANONICAL=F1MC78-1" }, "locus": { "chromosome": "10", "start_pos": 38402690, "end_pos": 38393627, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017326.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017326.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017326.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017326.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287AXW6-1", "protein_name": "Cyclin-D1-binding protein 1", "gene_name": "CCNDBP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MANAAPPDAPVPTLAVPLEQLRHLAEELRLLLPGVRVGEARETTKEFNRETFWRRFNEAAVTVSTEATTLTVVFSRLPLPSPQETQRFCEQVHAAIKAIIAAYYSLPKDQGTTLRKLVRSATLDIVDGMAQLVEMLYVTPTQSPENLISYNSVWDACQKVPKIPRDNKAAALSVLTKSVNLVKDAHEEMEQAVEECDPYCGLLNDIEEDNSDNHGDEEGILGCPNNQDSYWSEEDQELIIPCLALVRASKACLKKIRLSVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPVCHLTVRLNAAKLVSVLEKALEITKASHVTPQPEDSWIPLLINAVDHCMNRIKELTNEVEL", "length": 357 }, "evidence": [ { "id": "F1MC78", "url": "https://omabrowser.org/oma/group/F1MC78/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H0W0-1", "protein_name": "Cyclin-D1-binding protein 1", "gene_name": "Ccndbp1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASSAAAASFLAPTLEQLRHLAAELRSLLPLVRVGEAQETAEEFNREMFWRRLNEAAVNLSGEATILTTLFSRLPLPSPRETQRICEQIHVGIKEIIEVYYSLPKNQGITLRKLVRNATLDVVDGMAQLLEVLISPSQSTENCDLISCNSVSVACQKVSEIPKDNKAAALLMLTKCVNFVKDAHEEMEQAIEECDPYCGLLNGSEDNSDSHNDEDDVLGLPSNRDSYWSEEDQELINPCLALVRASRACLRKIRTLVAENGKKDQVSQLDDIVDISDEISPSVDVLVLSIYPPVCHLTVRINSAKLVSVLIKALEITKASHVTPQPEDSWIPLLINAIDRCMNRVKELTQHAANS", "length": 355 }, "evidence": [ { "id": "F1MC78", "url": "https://omabrowser.org/oma/group/F1MC78/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O95273-1", "protein_name": "Cyclin-D1-binding protein 1", "gene_name": "CCNDBP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASATAPAAAVPTLASPLEQLRHLAEELRLLLPRVRVGEAQETTEEFNREMFWRRLNEAAVTVSREATTLTIVFSQLPLPSPQETQKFCEQVHAAIKAFIAVYYLLPKDQGITLRKLVRGATLDIVDGMAQLMEVLSVTPTQSPENNDLISYNSVWVACQQMPQIPRDNKAAALLMLTKNVDFVKDAHEEMEQAVEECDPYSGLLNDTEENNSDNHNHEDDVLGFPSNQDLYWSEDDQELIIPCLALVRASKACLKKIRMLVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPMCHLTVRINSAKLVSVLKKALEITKASHVTPQPEDSWIPLLINAIDHCMNRIKELTQSELEL", "length": 360 }, "evidence": [ { "id": "F1MC78", "url": "https://omabrowser.org/oma/group/F1MC78/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3TVC7-1", "protein_name": "Cyclin-D1-binding protein 1", "gene_name": "Ccndbp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASSTAAVPFLAPPLEQLRHLAEELRSLLPRVRVGEAQETAEEFNREMFWRRLNEAAVKVNGEATVLTTHFSKLPWPSPQETQRICEQVRIAIEEIIIVYYSLPKDQGITLRKLVRNAALDIVDGMAQLLEVLLTAPSQSTENGDLISCNSVSVACQQVPEIPKDNKAAALLMLTKSVDFVKDAHEEMEQAVEECDPYSGLLNDSEDNSDSHSDEDGVLGLPSNRDSYWSEEDQELIIPCLALVRASRASLKKIRILVAENGKKDEVAQLDDIVDISDEISPSVDDLVLSIYPPVCHLTVRISSAKLVSVLIKALEITKASHVSPHPGDSWIPLLINAVDHCMNRIKALTQRAAEL", "length": 356 }, "evidence": [ { "id": "F1MC78", "url": "https://omabrowser.org/oma/group/F1MC78/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5BK06-1", "protein_name": "Cyclin-D1-binding protein 1", "gene_name": "Ccndbp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASSTTPVSFLAPPLEQLRHLAEELRSLLPRVRVGEAQETAEEFNREMFWRRLNEAAMKVSGEATVLTTLFSKIPSPSPQETQRICEQVHIATEEVIAAYYTFPKDQGITLRKLVRNAVLDIVDGTAQLLDALLAAPSQSPENGDLISCNSVSVACQQVAEIPKDNKAAALLMLTKSVDLVKDAHEEMEQAVEECDPYCGLLDDSEDNSDSHHNEDGVGLPSNRDSYWSEEDQALITPCLALVRASRASLKKIRILVAENGRKDQVAQLDDIVDISDEISPSVDDLVLSVYPPVCHLTVRITSAKLVSVLIKALEITKASHVSPQPGDSWIPLLINAVDHCMDRIKELTQRAVEL", "length": 355 }, "evidence": [ { "id": "F1MC78", "url": "https://omabrowser.org/oma/group/F1MC78/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MC78", "url": "https://www.uniprot.org/uniprotkb/F1MC78" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MC78", "url": "https://www.uniprot.org/uniprotkb/F1MC78" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "F1MC78", "url": "https://www.uniprot.org/uniprotkb/F1MC78" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MC78-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 358, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MC78-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MC78" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MC78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC78" }, { "id": "PF20936", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20936" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclin-D1-binding protein 1-like C-terminal", "eco_id": "ECO_0000259", "start_pos": 218, "end_pos": 318, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MC78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC78" }, { "id": "PF13324", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13324" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclin-D1-binding protein 1-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 56, "end_pos": 196, "start_aa": "Phe", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MC85-1", "uniprot_ac": "F1MC85", "uniprot_id": "F1MC85_BOVIN", "mass": { "chemical_mass": 49322.0, "monoisotopic_mass": 49322.0 }, "refseq": { "ac": "XP_059740792", "name": "G-protein coupled receptor 61 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740792" }, "gene_names": [ { "name": "GPR61", "type": "recommended", "evidence": [ { "id": "F1MC85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC85" } ] }, { "name": "GPR61", "type": "synonym", "evidence": [ { "id": "XP_059740792", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740792" } ] } ], "protein_names": [ { "name": "G-protein coupled receptor 61", "type": "recommended", "evidence": [ { "id": "F1MC85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC85/entry#names_and_taxonomy" } ] }, { "name": "G-protein coupled receptor 61 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_059740792", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740792" } ] } ], "function": [ { "annotation": "Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway. Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization. May be involved in the regulation of food intake and body weight.", "evidence": [ { "database": "UniProtKB", "id": "F1MC85", "url": "https://www.uniprot.org/uniprotkb/F1MC85#function" }, { "database": "UniProtKB", "id": "ARBA00058525", "url": "https://www.uniprot.org/uniprotkb/ARBA00058525#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MC85", "url": "https://www.uniprot.org/uniprotkb/F1MC85" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPR61", "url": "https://www.uniprot.org/uniprotkb/F1MC85", "locus": { "chromosome": "3", "start_pos": 33851550, "end_pos": 33910209, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013014", "url": "https://www.ensembl.org/id/ENSBTAG00000013014" } ] } } ], "crossref": [ { "id": "ENSBTAG00000013014", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013014", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15220", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15220", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "540581", "url": "https://www.ncbi.nlm.nih.gov/gene/540581", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WMETPRR", "url": "https://omabrowser.org/oma/group/WMETPRR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MC85", "url": "https://www.orthodb.org/?gene=F1MC85", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22752", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22752", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22752:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22752:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059740792", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740792", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MC85", "url": "https://www.uniprot.org/uniprotkb/F1MC85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC85-1", "url": "https://www.uniprot.org/uniprotkb/F1MC85-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESSPIPQSSGNSSTLGRAPQTPGPSTASGVPEAGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHDLFGEVACRLYLFLSICFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSREEGAPGVPLGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPVSTGQVENVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKQAPEEELRLPSREGSIEENFLQFLQSTGCPTESWASRPVPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAPSPRLES", "length": 451, "header": "tr|F1MC85-1|F1MC85_BOVIN Isoform 1 of G-protein coupled receptor 61 OS=Bos taurus OX=9913 GN=GPR61 PE=3 SV=1 CANONICAL=F1MC85-1" }, "isoforms": [ { "isoform_ac": "F1MC85-1", "url": "https://www.uniprot.org/uniprotkb/F1MC85/entry", "sequence": { "sequence": "MESSPIPQSSGNSSTLGRAPQTPGPSTASGVPEAGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHDLFGEVACRLYLFLSICFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSREEGAPGVPLGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPVSTGQVENVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKQAPEEELRLPSREGSIEENFLQFLQSTGCPTESWASRPVPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAPSPRLES", "length": 451, "header": "tr|F1MC85-1|F1MC85_BOVIN Isoform 1 of G-protein coupled receptor 61 OS=Bos taurus OX=9913 GN=GPR61 PE=3 SV=1 CANONICAL=F1MC85-1" }, "locus": { "chromosome": "3", "start_pos": 33855286, "end_pos": 33853934, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108097.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108097.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100989.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100989.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P737-1", "protein_name": "G protein-coupled receptor 61", "gene_name": "GPR61", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGHSMEPSLPAPWGWNGSRAARALQPSPGPMPPNGTADSKPKDVASKSVGLFFMLLIDLTAIVGNAAVMTVIVKTPALRKFVFVFHLCLVDFLAALTLMPLEMLSGSAVFDSPVLGEAMCRVYLFLSVCFISMCILSISTINVERYYYVVHPMRYEVRMTVGLVVCVLVGVWLKAVATSLVPVLGWLAPDRPPPAGRGCSLQWSRGPYCKFFVVFFAAFYFLLPLLIIVVVYCSMFKVARVAAMHHGPPPTWMETPRRRSESLSSRSTMVTTSGAPRTTPQRTFGGGKAAAILLAVGGQFLFCWLPYFSFHLYTALSAQPLAGPAAETVVTWLGYFCFTSNPFFYGCLNRQIRAELGRLLTCFFKQPPEEDLRLPSREGSIEENFLQFLQGTGCPAEPPPPPLGTPSPKRDPAPVDFRIPGQVGEDAAEGPERGGGDGPCVPKAGL", "length": 446 }, "evidence": [ { "id": "F1MC85", "url": "https://omabrowser.org/oma/group/F1MC85/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S602-1", "protein_name": "G-protein coupled receptor 61", "gene_name": "GPR61", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MESSPIPQSAGNASTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDQDLFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVAVWVKALAMASVPVLGRVSREEGAPSVPLGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPTSTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKQAPEEELRLPSREGSIEENFLQFLQGTGCPTESWVSRPVPSPKQEPAAVDFRIPGQIAEETSEFLEQHLTSDIVVSDGYLRPAPSPRRES", "length": 451 }, "evidence": [ { "id": "F1MC85", "url": "https://omabrowser.org/oma/group/F1MC85/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P08753-1", "protein_name": "Guanine nucleotide-binding protein G(i) subunit alpha-3", "gene_name": "Gnai3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAGSAEEGVMTSELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQTNYIPTQQDVLRTRVKTTGIVETHFTFKELYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEVYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY", "length": 354 }, "evidence": [ { "id": "F1MC85", "url": "https://omabrowser.org/oma/group/F1MC85/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8C010-1", "protein_name": "G protein-coupled receptor 61", "gene_name": "Gpr61", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESSPIPQSSGNSSTLGRALQTPGPSTASGVPELGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVYWEEGAPSVNPGCSLQWSHSAYCQLFVVVFAVLYFLLPLILIFVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAHQTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISAGQVENVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKAAPEEELRLPSREGSIEENFLQFLQGTSENWVSRPLPSPKREPPPVVDFRIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAPSPRLES", "length": 449 }, "evidence": [ { "id": "F1MC85", "url": "https://omabrowser.org/oma/group/F1MC85/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BZJ8-1", "protein_name": "G protein-coupled receptor 61", "gene_name": "GPR61", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAASPRLES", "length": 451 }, "evidence": [ { "id": "F1MC85", "url": "https://omabrowser.org/oma/group/F1MC85/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MC85", "url": "https://www.uniprot.org/uniprotkb/F1MC85" } ], "pmid": "" }, { "name": "arrestin family protein binding", "id": "GO:1990763", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990763", "evidence": [ { "database": "UniProtKB", "id": "F1MC85", "url": "https://www.uniprot.org/uniprotkb/F1MC85" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "F1MC85", "url": "https://www.uniprot.org/uniprotkb/F1MC85" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MC85", "url": "https://www.uniprot.org/uniprotkb/F1MC85" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "F1MC85", "url": "https://www.uniprot.org/uniprotkb/F1MC85" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "F1MC85", "url": "https://www.uniprot.org/uniprotkb/F1MC85" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0038035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038035", "evidence": [ { "database": "UniProtKB", "id": "F1MC85", "url": "https://www.uniprot.org/uniprotkb/F1MC85" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MC85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC85" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 59, "end_pos": 341, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MC97-1", "uniprot_ac": "F1MC97", "uniprot_id": "F1MC97_BOVIN", "mass": { "chemical_mass": 34454.0, "monoisotopic_mass": 34454.0 }, "refseq": {}, "gene_names": [ { "name": "OR5T2", "type": "recommended", "evidence": [ { "id": "F1MC97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC97" } ] }, { "name": "OR5T21", "type": "synonym", "evidence": [ { "id": "F1MC97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC97" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1MC97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC97/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MC97", "url": "https://www.uniprot.org/uniprotkb/F1MC97#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MC97", "url": "https://www.uniprot.org/uniprotkb/F1MC97" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR5T2", "url": "https://www.uniprot.org/uniprotkb/F1MC97", "locus": { "chromosome": "15", "start_pos": 79455708, "end_pos": 79456628, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000057857", "url": "https://www.ensembl.org/id/ENSBTAG00000057857" } ] } } ], "crossref": [ { "id": "F1MC97", "url": "https://alphafold.ebi.ac.uk/entry/F1MC97", "database": "AlphaFoldDB", "categories": [] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515598", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515598", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MC97", "url": "https://www.orthodb.org/?gene=F1MC97", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MC97", "url": "https://www.uniprot.org/uniprotkb/F1MC97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MC97-1", "url": "https://www.uniprot.org/uniprotkb/F1MC97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKNTTEVTIFVLKGLTDNPEIQFILFFLFLAMYLFTLIGNLGLVVLVIGDCRLHNPMYYFLSVLSSVDACYSSVITPKMLADFMSKNKTILLSECAAQMFLFTTFGTTECFLLAAMAYDRYVAIYDPLLYSVSMAPRVYVPLIIASYVGGIVHATVHTVATFSLSFCASNEIRHVFCDIPPLLAISCSDTHTNQLLLFYLVGSIEIVTVLIVLISYSFILLAVLRMHSAEGRRKVFSTCGSHLTGVCIFHGTILFMYVRPSSSYALDHDMIVSLFYSVVIPMLNPIIYSLRNKDVKEAMKRMFWRI", "length": 306, "header": "tr|F1MC97-1|F1MC97_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5T2 PE=3 SV=4 CANONICAL=F1MC97-1" }, "isoforms": [ { "isoform_ac": "F1MC97-1", "url": "https://www.uniprot.org/uniprotkb/F1MC97/entry", "sequence": { "sequence": "MKNTTEVTIFVLKGLTDNPEIQFILFFLFLAMYLFTLIGNLGLVVLVIGDCRLHNPMYYFLSVLSSVDACYSSVITPKMLADFMSKNKTILLSECAAQMFLFTTFGTTECFLLAAMAYDRYVAIYDPLLYSVSMAPRVYVPLIIASYVGGIVHATVHTVATFSLSFCASNEIRHVFCDIPPLLAISCSDTHTNQLLLFYLVGSIEIVTVLIVLISYSFILLAVLRMHSAEGRRKVFSTCGSHLTGVCIFHGTILFMYVRPSSSYALDHDMIVSLFYSVVIPMLNPIIYSLRNKDVKEAMKRMFWRI", "length": 306, "header": "tr|F1MC97-1|F1MC97_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5T2 PE=3 SV=4 CANONICAL=F1MC97-1" }, "locus": { "chromosome": "15", "start_pos": 79083225, "end_pos": 79082308, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053751.4", "url": "https://www.ensembl.org/id/ENSBTAT00000053751.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048221.4", "url": "https://www.ensembl.org/id/ENSBTAP00000048221.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515598", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515598", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MC97", "url": "https://www.uniprot.org/uniprotkb/F1MC97" } ], 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Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation.", "evidence": [ { "database": "UniProtKB", "id": "F1MCE3", "url": "https://www.uniprot.org/uniprotkb/F1MCE3#function" }, { "database": "UniProtKB", "id": "ARBA00060088", "url": "https://www.uniprot.org/uniprotkb/ARBA00060088#function" }, { "database": "UniProtKB", "id": "G3N291", "url": "https://www.uniprot.org/uniprotkb/G3N291#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MCE3", "url": "https://www.uniprot.org/uniprotkb/F1MCE3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FYB2", "url": "https://www.uniprot.org/uniprotkb/F1MCE3", "locus": { "chromosome": "3", "start_pos": 89465198, "end_pos": 89336175, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009314", "url": "https://www.ensembl.org/id/ENSBTAG00000009314" } ] } } ], "crossref": [ { "id": "F1MCE3", "url": "https://alphafold.ebi.ac.uk/entry/F1MCE3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009314", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009314", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615569", "url": "https://www.ncbi.nlm.nih.gov/gene/615569", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029294", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615569", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615569", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KPWKNFP", "url": "https://omabrowser.org/oma/group/KPWKNFP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MCE3", "url": "https://www.orthodb.org/?gene=F1MCE3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16830", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16830", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16830:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16830:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF14603", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14603", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010801851", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010801851", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MCE3", "url": "https://www.uniprot.org/uniprotkb/F1MCE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCE3-1", "url": "https://www.uniprot.org/uniprotkb/F1MCE3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N291", "url": "https://www.uniprot.org/uniprotkb/G3N291", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N291-1", "url": "https://www.uniprot.org/uniprotkb/G3N291-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAGARPAAGESAPTPAEGGAAAQVGQVGSLSAGVSAARGSACSLAGAGRAKRALGLRIQLWEAGFVSQTLPRKKVMEAEGLRNFKELRAKFQNLDASSLSGPIKFPAGVSQKGDFGSRQSMKTSASGKPPSSSHNQHSPNCADGDPQPLKPQQVKGTQKSETQKCSNYLEQPSFPGSAVRSQKASPLLDVYQSNGEIANKKKVMVNDSFRNKLWSWEVLSQKSETPSIFLPASCGSRAFHLKEQKSIKLTSQEPMENMEIKEAQSLPSHRHLMAQRRLCAISEDPTVQPSQCSRESEANSSPERSLTGSICHPVYDNELTSQTSEEQPDARHPQLPNTKPLPSVESLGPPPPKPPRPPVVTLQAFQRQAAALSKPDGEEATKEGSLPPVSAEFEEPHNYEATISYLRHSSNSINLCTAKKSADSTYEVRIEELRKAWKSFYHQELTPQHEDEDKQMKEKEPYQLKLQNTEDLHLDHLFKVDIYEEIPGKTQMAEDHTGGRIMPARKQDAAMDIIQVEACPEDFQPARLPIDYCGYAKALEMTKETQGQGAIKPNSISENYDDVECSGSKSSDGKASLKRLQRFFKKEKDRLKVNRINSKENIRAFSLSLPDLKLRSQEVIIYDDVAINGKQPNDELKGKSWKLKFLTLKEKKKKGAKESERSFFKIKKQNLQKDRMKREERLFRERFKYDKEITVINTAVVCSNNSRNGISDLPITPGEELDVIDITEENLVICRNSEGKYGYVLIEHLDFKQQV", "length": 756, "header": "tr|F1MCE3-1|F1MCE3_BOVIN Isoform 1 of FYN-binding protein 2 OS=Bos taurus OX=9913 GN=FYB2 PE=4 SV=3 CANONICAL=F1MCE3-1" }, "isoforms": [ { "isoform_ac": "F1MCE3-1", "url": "https://www.uniprot.org/uniprotkb/F1MCE3/entry", "sequence": { "sequence": "MEAGARPAAGESAPTPAEGGAAAQVGQVGSLSAGVSAARGSACSLAGAGRAKRALGLRIQLWEAGFVSQTLPRKKVMEAEGLRNFKELRAKFQNLDASSLSGPIKFPAGVSQKGDFGSRQSMKTSASGKPPSSSHNQHSPNCADGDPQPLKPQQVKGTQKSETQKCSNYLEQPSFPGSAVRSQKASPLLDVYQSNGEIANKKKVMVNDSFRNKLWSWEVLSQKSETPSIFLPASCGSRAFHLKEQKSIKLTSQEPMENMEIKEAQSLPSHRHLMAQRRLCAISEDPTVQPSQCSRESEANSSPERSLTGSICHPVYDNELTSQTSEEQPDARHPQLPNTKPLPSVESLGPPPPKPPRPPVVTLQAFQRQAAALSKPDGEEATKEGSLPPVSAEFEEPHNYEATISYLRHSSNSINLCTAKKSADSTYEVRIEELRKAWKSFYHQELTPQHEDEDKQMKEKEPYQLKLQNTEDLHLDHLFKVDIYEEIPGKTQMAEDHTGGRIMPARKQDAAMDIIQVEACPEDFQPARLPIDYCGYAKALEMTKETQGQGAIKPNSISENYDDVECSGSKSSDGKASLKRLQRFFKKEKDRLKVNRINSKENIRAFSLSLPDLKLRSQEVIIYDDVAINGKQPNDELKGKSWKLKFLTLKEKKKKGAKESERSFFKIKKQNLQKDRMKREERLFRERFKYDKEITVINTAVVCSNNSRNGISDLPITPGEELDVIDITEENLVICRNSEGKYGYVLIEHLDFKQQV", "length": 756, "header": "tr|F1MCE3-1|F1MCE3_BOVIN Isoform 1 of FYN-binding protein 2 OS=Bos taurus OX=9913 GN=FYB2 PE=4 SV=3 CANONICAL=F1MCE3-1" }, "locus": { "chromosome": "3", "start_pos": 89464194, "end_pos": 89336374, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012267.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012267.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012267.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012267.6" } ] } }, { "isoform_ac": "G3N291-1", "url": "https://www.uniprot.org/uniprotkb/G3N291/entry", "sequence": { "sequence": "MKEGLRNFKELRAKFQNLDASSLSGPIKFPAGVSQKGDFGSRQSMKTSASGKPPSSSHNQHSPNCADGDPQPLKPQQVKGTQKSETQKCSNYLEQPSFPGSAVRSQKASPLLDVYQSNGEIANKKKVMVNDSFRNKLWSWEVLSQKSETPSIFLPASCGSRAFHLKEQKSIKLTSQEPMENMEIKEAQSLPSHRHLMAQRRLCAISEDPTVQPSQCSRESEANSSPERSLTGSICHPVYDNELTSQTSEEQPDARHPQLPNTKPLPSVESLGPPPPKPPRPPVVTLQAFQRQAAALSKPDGEEATKEGSLPPVSAEFEEPHNYEATISYLRHSSNSINLCTAKKSADSTYEVRIEELRKAWKSFYHQELTPQHEDEDKQMKEKEPYQLKLQNTEDLHLDHLFKVDIYEEIPGKTQMAEDHTGGRIMPARKQDAAMDIIQVEACPEDFQPARLPIDYCGYAKALEMTKETQGQGAIKPNSISENYDDVECSGSKSSDGKASLKRLQRFFKKEKDRLKVNRINSKENIRAFSLSLPDLKLRSQEVIIYDDVAINGKQPNDELKGKSWKLKFLTLKEKKKKGAKESERSFFKIKKQNLQKDRMKREERLFRERFKYDKEITVINTAVVCSNNSRNGISDLPITPGEELDVIDITEENLVICRNSEGKYGYVLIEHLDFKQQV", "length": 679, "header": "tr|G3N291-1|F1MCE3_BOVIN Computationally mapped isoform of FYN-binding protein 2 OS=Bos taurus OX=9913 GN=FYB2 PE=4 SV=3 CANONICAL=F1MCE3-1" }, "locus": { "chromosome": "3", "start_pos": 89464194, "end_pos": 89357439, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063304.4", "url": "https://www.ensembl.org/id/ENSBTAT00000063304.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056001.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056001.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 15, "start_aa": "Thr", "end_pos": 15, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr15", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 717, "start_aa": "Thr", "end_pos": 717, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr717", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:615569", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615569", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6A116-1", "protein_name": "FYN-binding protein 2", "gene_name": "Fyb2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEARPPEGGRSHCPGGAGGESRFQPVPDRGSDCTLAGGGGSVVGPKIQLWEAGIVSQSEPRRTTMEEEGIRNFKELRAKFQKLNAVPLSGPIKLPAGVSRKDGRGYTQPSQDPANRKHLSSHHYRTPSNSSAGLSHPLKTQKIKSAQRDDVQKSSLGTPENSTVYPERNFQKAAMPLDVNKSRSETSNEERGMTLSSFRCKLWNWEKVSSQKSEMSPTALLTNGRLKTFHLEGHKTMGLAQEKPEKNLKTTEAQPLPPQNHLMAQGKSPIASKASKGSLPRYSRKQTESPGTEGSHESSPCQPVYECELVSLVPEKPESQHCQLPKTKPLPSIETLGPPPPKPSKPPFVNIYAFPRQPAVVSKSLKEVTTKESPLPPDSAELEEAHNYDTTISYLRHSGNSINLCAAGESAEATYEIEIEELQKPQRGILLPELSPRPKDGENTTREKEPCASEPPKPGKVSYPKHPSKIAVCEGTPGKTQMSGVQENRRSMPAGNQQAIIDIIQSRHFQEDAMLTRHSQGKSGYVEALGVTKETPSPSTVRSSSSSEKTYDDVECSREDIQKWDFSSSFTSDSEENSEETYEDIYRAKTSDPKTDAAGRAALRRLQQLFSRENGVFRMKKTKSKEIVSNGFSMSLPDLGPRSHDGIIYDDVDAREKESKVKTWKAKFLTPRGKKGKGSRGSKRFSPKNFFRTKKKKLEKNRVEKEEKLFRERFQYGKEIMVINRAVACSGNSRNGIFDLPITPGEQLEVIDTTEQNLVICRNSKGKYGYVLIEHLDFKHQG", "length": 782 }, "evidence": [ { "id": "F1MCE3", "url": "https://omabrowser.org/oma/group/F1MCE3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A2A995-1", "protein_name": "FYN-binding protein 2", "gene_name": "Fyb2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEEEGIRNFKELRAKFQKFNAAPLPGPMRFPAGVSRKHDRGSTQPAQDLANRKCLSSHHHQTPSHSSTGVSQPLKNQTLKSAQGDELQKTSSSSGTPEKSTVCPERDFQKAAVPLDVTKSRAKTSNEEKGMTLSSFRYKLWNWEKVSSQNGEMSPAPLLTNGGIKTFHFEGQKTMGLAQDKPEKSLKATGAQTLPPQSHSMAQRKSPVTSKASSVSLPPHSRKSTKSPATEGSHRSSQCQPVYECELDSLVPEKPQSRHCRLPKTKPLPSIETLGPPPPKPSKPPFVNLYAFHRLPATVTKTPKEETMKEGPLSPDSAELEEAHNYDTTISYLRHSGNSINLCAEGESTEATYEIEIEELQKPWRSFFLPELSPRPKEEENTMEEKESWESEPLEPRKELHPSRPPKVVVYKETPGKTQMAGVHEDRRSVPAGNQEAMTDIMQNRLFPEDVTLTRHSQDKSGYVEALEVTKETPSPSTIRSSSSSEKTYDAVECSREDVRKWDFSSSFTSDSEENCEEMYEDIYKAKNDDPKTEVAGRTALRKLQQIFRKENVVFRMKKTKSKEIVSNGFSVSLPDLGPRSQDDSQDGIIYDDVDTREKESNDEDKVKTWKTKFLIPKGKKWGKGSQGSKSFSPRHFFRTKKQKLEKNRMEKEEKLFRERFQYGKEILVINRAVACASNSRNGMFDLPIIPGEQLEVIDTTEQNLVICRNSKGKYGYVLVEHLDFKHQG", "length": 729 }, "evidence": [ { "id": "F1MCE3", "url": "https://omabrowser.org/oma/group/F1MCE3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5VWT5-1", "protein_name": "FYN-binding protein 2", "gene_name": "FYB2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGEGVRNFKELRAKFQNLDAPPLPGPIKFPAGVSPKGDIGGTQSTQILANGKPLSSNHKQRTPYCSSSESQPLQPQKIKLAQKSEIPKCSNSPGPLGKSTVCSATSSQKASLLLEVTQSNVEIITKEKVMVANSFRNKLWNWEKVSSQKSEMSSALLLANYGSKAIHLEGQKGMGLTPEEPRKKLETKGAQTLPSQKHVVAPKILHNVSEDPSFVISQHIRKSWENPPPERSPASSPCQPIYECELASQAPEKQPDVRHHHLPKTKPLPSIDSLGPPPPKPSRPPIVNLQAFQRQPAAVPKTQGEVTVEEGSLSPERLFNAEFEEPHNYEATISYLRHSGNSINLCTAKEIADPTYEVGIEELQKPGKNFPYPEPSAKHEDKKMKEKQPCELKPKNTEKEPYSNHVFKVDACEGTPEKIQMTNVHTGRRNMLAGKQEAMIDIIQTNPCPEGPKLARHSQGHCGHLEVLESTKETPDLGVSKTSSISEEIYDDVEYSRKEVPKLNYSSSLASSSEENRELYEDVYKTKNNYPKIDLDGKEALKRLQQFFKKEKDRFKIKKTKSKENLSAFSILLPDLELKSQEVIIYDDVDLSEKESKDEDKLKMWKPKFLTPKEKKEKNGAEESESFSPRNFFKTKKQNLEKNRMKREEKLFRERFKYDKEIIVINTAVACSNNSRNGIFDLPISPGEELEVIDTTEQNLVICRNSKGKYGYVLIEHLDFKHQSWSP", "length": 728 }, "evidence": [ { "id": "F1MCE3", "url": "https://omabrowser.org/oma/group/F1MCE3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MCE3", "url": "https://www.uniprot.org/uniprotkb/F1MCE3" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "F1MCE3", "url": "https://www.uniprot.org/uniprotkb/F1MCE3" } ], "pmid": "" }, { "name": "immunological synapse", "id": "GO:0001772", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001772", "evidence": [ { "database": "UniProtKB", "id": "F1MCE3", "url": "https://www.uniprot.org/uniprotkb/F1MCE3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "integrin-mediated signaling pathway", "id": "GO:0007229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "evidence": [ { "database": "UniProtKB", "id": "F1MCE3", "url": "https://www.uniprot.org/uniprotkb/F1MCE3" } ], "pmid": "" }, { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "F1MCE3", "url": "https://www.uniprot.org/uniprotkb/F1MCE3" } ], "pmid": "" }, { "name": "T cell receptor signaling pathway", "id": "GO:0050852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852", "evidence": [ { "database": "UniProtKB", "id": "F1MCE3", "url": "https://www.uniprot.org/uniprotkb/F1MCE3" } ], "pmid": "" }, { "name": "cell adhesion mediated by integrin", "id": "GO:0033627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033627", "evidence": [ { "database": "UniProtKB", "id": "F1MCE3", "url": "https://www.uniprot.org/uniprotkb/F1MCE3" } ], "pmid": "" } ] } ] 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], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "NAD+ kinase activity", "id": "GO:0003951", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003951", "evidence": [ { "database": "UniProtKB", "id": "F1MCL6", "url": "https://www.uniprot.org/uniprotkb/F1MCL6" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MCL6", "url": "https://www.uniprot.org/uniprotkb/F1MCL6" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MCL6", "url": "https://www.uniprot.org/uniprotkb/F1MCL6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MCL6", "url": 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"glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MCM2-1", "uniprot_ac": "F1MCM2", "uniprot_id": "F1MCM2_BOVIN", "mass": { "chemical_mass": 103994.0, "monoisotopic_mass": 103994.0 }, "refseq": { "ac": "NP_001192932", "name": "glutamate receptor ionotropic, kainate 3 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192932" }, "gene_names": [ { "name": "GRIK3", "type": "recommended", "evidence": [ { "id": "F1MCM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCM2" } ] }, { "name": "GRIK3", "type": "synonym", "evidence": [ { "id": "NP_001192932", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192932" } ] } ], "protein_names": [ { "name": "Glutamate receptor", "type": "recommended", "evidence": [ { "id": "F1MCM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCM2/entry#names_and_taxonomy" } ] }, { "name": "glutamate receptor ionotropic, kainate 3 precursor", "type": "synonym", "evidence": [ { "id": "NP_001192932", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192932" } ] } ], "function": [ { "annotation": "Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.", "evidence": [ { "database": "UniProtKB", "id": "F1MCM2", "url": "https://www.uniprot.org/uniprotkb/F1MCM2#function" }, { "database": "UniProtKB", "id": "RU367118", "url": "https://www.uniprot.org/uniprotkb/RU367118#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MCM2", "url": "https://www.uniprot.org/uniprotkb/F1MCM2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GRIK3", "url": "https://www.uniprot.org/uniprotkb/F1MCM2", "locus": { "chromosome": "3", "start_pos": 109077298, "end_pos": 108832825, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009269", "url": "https://www.ensembl.org/id/ENSBTAG00000009269" } ] } } ], "crossref": [ { "id": "F1MCM2", "url": "https://alphafold.ebi.ac.uk/entry/F1MCM2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009269", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009269", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06382", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06382", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13723", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13723", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "532553", "url": "https://www.ncbi.nlm.nih.gov/gene/532553", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019594", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019594", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532553", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532553", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SMTCLGD", "url": "https://omabrowser.org/oma/group/SMTCLGD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MCM2", "url": "https://www.orthodb.org/?gene=F1MCM2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18966", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18966", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00060", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00060", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01094", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01094", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10613", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10613", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192932", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MCM2", "url": "https://www.uniprot.org/uniprotkb/F1MCM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCM2-1", "url": "https://www.uniprot.org/uniprotkb/F1MCM2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTAPWRRLGSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPLDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRAESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPAEGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLFGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMIKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMTCSTSLAPVFP", "length": 919, "header": "tr|F1MCM2-1|F1MCM2_BOVIN Isoform 1 of Glutamate receptor OS=Bos taurus OX=9913 GN=GRIK3 PE=3 SV=4 CANONICAL=F1MCM2-1" }, "isoforms": [ { "isoform_ac": "F1MCM2-1", "url": "https://www.uniprot.org/uniprotkb/F1MCM2/entry", "sequence": { "sequence": "MTAPWRRLGSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPLDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRAESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPAEGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLFGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMIKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMTCSTSLAPVFP", "length": 919, "header": "tr|F1MCM2-1|F1MCM2_BOVIN Isoform 1 of Glutamate receptor OS=Bos taurus OX=9913 GN=GRIK3 PE=3 SV=4 CANONICAL=F1MCM2-1" }, "locus": { "chromosome": "3", "start_pos": 109076294, "end_pos": 108832825, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012214.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012214.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012214.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012214.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:532553", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532553", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B1AS29-1", "protein_name": "Glutamate receptor ionotropic, kainate 3", "gene_name": "Grik3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTAPWRRLRSLVWEYWAGFLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWAMERLQAAPRAESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQRSFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMSCSTSLAPVFP", "length": 919 }, "evidence": [ { "id": "F1MCM2", "url": "https://omabrowser.org/oma/group/F1MCM2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "E7FEG9-1", "protein_name": "Glutamate receptor", "gene_name": "grik3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKNRREYVEYRSAIIVVLFWIQSSFGMPHVIRIGGIFEQTDGPVALVSSEELAFKFAVNNINRNRTLLPNTTLTYDIQRINIYDSFEASRKACDQLSLGVVAIFGPSHSSSSNAVQSICNALEVPHIQVRWKHHPMDNRDTFYANLYPDYSSLSYAILDLVQFLKWKTATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPMDTVDTRPLLKEMKRSREFRIIFDCSHTMAAQILKQAQMMGMMTEYYHYIFTTLDLMAINLEPYRFCGVNMTGFRILNVDNPQVASIVEKWSLERQIPPKPDSGLLEGIMTTDAALTYDAVHIVSVSYQHAPQMTVNSLQCHRHKPWRFGGRFMSFIKESHWDGLTGRLCFNRTTGLRTDFDLDIVSLKEDGLQKVGKWSASGGLNITEVPRQNGMNITDSLSNRSLVITTILEEPYVMLKKSDKALVGNDRFEGFCIDLLKELASILGFSYEIHLVPDGKYGFQDDKGQWNGMIRELMEHRADLAVAPLTITFMREKAIDFSKPFLNTGISILYRKPNSTNSGFFSFLNPMTPDIWVYILLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSDVVENNFTLLNSFWFGVGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMDSPVDSADDLAKQTKIEYGVVKDGATMSFFKKSRVSTFEKMWAFMSSRQSTSFVKSIEDGIQRVLKSDYALLMESTTIEYVTRRNCNLTQVGGIIDSKGYGIGTPKGSPYRDKITIAILGILEDGRLHMLKEKWWSGSSCLEDERYETGPMGIQNLGGIFIVLASGLVLSVFVAIGEFIYKLRKTAEREQVFLQCGDGRDQTVVHVRETGEAQAPPAAASHAEDGRSDQHALLQRPSPARKGQHELQHRDDARVSMTCLGDGHLRHVPGAVPESRDYGSEMITAFTINRRDIRHQMASQNGGSSSKPGSDHILKPMYPTMPLREGGRSVSFL", "length": 991 }, "evidence": [ { "id": "F1MCM2", "url": "https://omabrowser.org/oma/group/F1MCM2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1P0L4-1", "protein_name": "Glutamate receptor", "gene_name": "GRIK3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTQPWPALRGVLWEYCAALLLGGFWGHCSHGMPHVIRIGGIFEYTDGPNTQVMSAEEQAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPLDTDDARPLLKEMKRGREFRIIFDCSHLMAAQILRQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVENPHVSSIIEKWAMERLQSAPKAELGLLDGVMMTDAALLYDAVHVVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKSSGLRTDFDLDIISLKEDGLEKVGTWNPSNGLNITEISKGRGPNVTDSLSNRSLIVTTVLEEPFVMFRKSDTALFGNDRFEGYCIDLLKELAVILGFTYEIRLVEDGKYGAQDDKGQWNGMIKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSDIVENNFTLFNSFWFGMGALMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPTALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQVGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHVMKEKWWRGNGCPEDENKEASALGIQNIGGIFIVLAAGLVLSVFVAMVEFIYKLRKTAEREQRSFCSAVADEIRLSLTCQRRVKHKPPPPVMVKADAVINMHTFNDRRLPGKDSMSCNTGLTPVFP", "length": 919 }, "evidence": [ { "id": "F1MCM2", "url": "https://omabrowser.org/oma/group/F1MCM2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P42264-1", "protein_name": "Glutamate receptor ionotropic, kainate 3", "gene_name": "Grik3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTAPWRRLRSLVWEYWAGFLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNAHVSAIVEKWSMERLQAAPRAESGLLDGVMMTDAALLYDAVHIVSVCYQRASQMTVNSLQCHRHKPWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQRSFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMSCSTSLAPVFP", "length": 919 }, "evidence": [ { "id": "F1MCM2", "url": "https://omabrowser.org/oma/group/F1MCM2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q13003-1", "protein_name": "Glutamate receptor ionotropic, kainate 3", "gene_name": "GRIK3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMACSTSLAPVFP", "length": 919 }, "evidence": [ { "id": "F1MCM2", "url": "https://omabrowser.org/oma/group/F1MCM2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8GXJ4-1", "protein_name": "Glutamate receptor 3.4", "gene_name": "GLR3.4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGFLVMIREVSMAKAIRVVLLCVSVLWVVPKECACRSNFSRNSSSSSSSSLRPLRQRPSSVNVGALFTYDSFIGRAAKPAVKAAMDDVNADQSVLKGIKLNIIFQDSNCSGFIGTMGALQLMENKVVAAIGPQSSGIAHMISYVANELHVPLLSFGATDPTLSSLQFPYFLRTTQNDYFQMHAIADFLSYSGWRQVIAIFVDDECGRNGISVLGDVLAKKRSRISYKAAITPGADSSSIRDLLVSVNLMESRVFVVHVNPDSGLNVFSVAKSLGMMASGYVWIATDWLPTAMDSMEHVDSDTMDLLQGVVAFRHYTIESSVKRQFMARWKNLRPNDGFNSYAMYAYDSVWLVARALDVFFRENNNITFSNDPNLHKTNGSTIQLSALSVFNEGEKFMKIILGMNHTGVTGPIQFDSDRNRVNPAYEVLNLEGTAPRTVGYWSNHSGLSVVHPETLYSRPPNTSTANQRLKGIIYPGEVTKPPRGWVFPNNGKPLRIGVPNRVSYTDYVSKDKNPPGVRGYCIDVFEAAIELLPYPVPRTYILYGDGKRNPSYDNLVNEVVADNFDVAVGDITIVTNRTRYVDFTQPFIESGLVVVAPVKEAKSSPWSFLKPFTIEMWAVTGGFFLFVGAMVWILEHRFNQEFRGPPRRQLITIFWFSFSTMFFSHRENTVSSLGRFVLIIWLFVVLIINSSYTASLTSILTIRQLTSRIEGIDSLVTSNEPIGVQDGTFARNYLINELNILPSRIVPLKDEEQYLSALQRGPNAGGVAAIVDELPYIEVLLTNSNCKFRTVGQEFTRTGWGFAFQRDSPLAVDMSTAILQLSEEGELEKIHRKWLNYKHECSMQISNSEDSQLSLKSFWGLFLICGITCFMALTVFFWRVFWQYQRLLPESADEERAGEVSEPSRSGRGSRAPSFKELIKVVDKREAEIKEILKQKSSKKLKSTQSAAGTSQSQHGEIT", "length": 959 }, "evidence": [ { "id": "F1MCM2", "url": "https://omabrowser.org/oma/group/F1MCM2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "glutamate-gated calcium ion channel activity", "id": "GO:0022849", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022849", "evidence": [ { "database": "UniProtKB", "id": "F1MCM2", "url": "https://www.uniprot.org/uniprotkb/F1MCM2" } ], "pmid": "" }, { "name": "adenylate cyclase inhibiting G protein-coupled glutamate receptor activity", "id": "GO:0001640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001640", "evidence": [ { "database": "UniProtKB", "id": "F1MCM2", "url": "https://www.uniprot.org/uniprotkb/F1MCM2" } ], "pmid": "" }, { "name": "kainate selective glutamate receptor activity", "id": "GO:0015277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015277", "evidence": [ { "database": "UniProtKB", "id": "F1MCM2", "url": 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[ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29671" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { 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"count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MCP4-1", "uniprot_ac": "F1MCP4", "uniprot_id": "F1MCP4_BOVIN", "mass": { "chemical_mass": 61679.0, "monoisotopic_mass": 61679.0 }, "refseq": { "ac": "NP_001029643", "name": "glycerophosphoinositol inositolphosphodiesterase GDPD2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029643" }, "gene_names": [ { "name": "GDPD2", "type": "recommended", "evidence": [ { "id": "F1MCP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCP4" } ] }, { "name": "GDPD2", "type": "synonym", "evidence": [ { "id": "NP_001029643", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029643" } ] } ], "protein_names": [ { "name": "Glycerophosphodiester phosphodiesterase domain containing 2", "type": 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"https://www.ensembl.org/id/ENSBTAG00000012863" } ] } } ], "crossref": [ { "id": "F1MCP4", "url": "https://alphafold.ebi.ac.uk/entry/F1MCP4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000012863", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000012863", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514673", "url": "https://www.ncbi.nlm.nih.gov/gene/514673", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR017946", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017946", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514673", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514673", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DPPGCCS", "url": "https://omabrowser.org/oma/group/DPPGCCS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MCP4", "url": "https://www.orthodb.org/?gene=F1MCP4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23344", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23344", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23344:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23344:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03009", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03009", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029643", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MCP4", "url": "https://www.uniprot.org/uniprotkb/F1MCP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCP4-1", "url": "https://www.uniprot.org/uniprotkb/F1MCP4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAESPGCCSVWARCFHCLYSCHWKKCPRDRMQTNKCECVWFGLLFLTFLLSLGWLYVVLILLNDLHNFNEFLFQRWGHWMDWSPAFLLVISLLVTYASLLLLLALLLWLYGQPLCLHTVHKVLLLLIIFLVAAGLVGLEVQWQEEWHSLRLSLQATAPFLHIGAAAGITLLAWPVADTFYHIHRRGPKILLLLLYFGATLGIYLAPLFISSACIMEPKDLPHKPKLIGHRGAPMLAPENTLMSLRKTAECGAIVFETDVMVSSDGIPFLMHDERLTRTTDVASVFPDRVNSHSSDFSWAELKRLNAGAWFLQRQPFWGAKQLSGHDQEDAESQTVPSLEEILKEAEGLNLSIIFDLRCPPENHTYHDSFVNQTLETVLSSGVPQAMVLWLPDEDRAYVQERAPQMRQIYGHLEGHGTESPQFLNLPYQDLPLLDIKALHHDNVSVNLFVVNKPWLFSLLWCAGVDSVTTNDCQLLQQMRYPVWLIPARTYLIIWIITNCVSLLLLLWTFLLQQRCAKERQRTGLETAVLLTRINNFIRE", "length": 539, "header": "tr|F1MCP4-1|F1MCP4_BOVIN Isoform 1 of Glycerophosphodiester phosphodiesterase domain containing 2 OS=Bos taurus OX=9913 GN=GDPD2 PE=3 SV=1 CANONICAL=F1MCP4-1" }, "isoforms": [ { "isoform_ac": "F1MCP4-1", "url": "https://www.uniprot.org/uniprotkb/F1MCP4/entry", "sequence": { "sequence": "MAESPGCCSVWARCFHCLYSCHWKKCPRDRMQTNKCECVWFGLLFLTFLLSLGWLYVVLILLNDLHNFNEFLFQRWGHWMDWSPAFLLVISLLVTYASLLLLLALLLWLYGQPLCLHTVHKVLLLLIIFLVAAGLVGLEVQWQEEWHSLRLSLQATAPFLHIGAAAGITLLAWPVADTFYHIHRRGPKILLLLLYFGATLGIYLAPLFISSACIMEPKDLPHKPKLIGHRGAPMLAPENTLMSLRKTAECGAIVFETDVMVSSDGIPFLMHDERLTRTTDVASVFPDRVNSHSSDFSWAELKRLNAGAWFLQRQPFWGAKQLSGHDQEDAESQTVPSLEEILKEAEGLNLSIIFDLRCPPENHTYHDSFVNQTLETVLSSGVPQAMVLWLPDEDRAYVQERAPQMRQIYGHLEGHGTESPQFLNLPYQDLPLLDIKALHHDNVSVNLFVVNKPWLFSLLWCAGVDSVTTNDCQLLQQMRYPVWLIPARTYLIIWIITNCVSLLLLLWTFLLQQRCAKERQRTGLETAVLLTRINNFIRE", "length": 539, "header": "tr|F1MCP4-1|F1MCP4_BOVIN Isoform 1 of Glycerophosphodiester phosphodiesterase domain containing 2 OS=Bos taurus OX=9913 GN=GDPD2 PE=3 SV=1 CANONICAL=F1MCP4-1" }, "locus": { "chromosome": "X", "start_pos": 80019468, "end_pos": 80012284, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017095.6", "url": "https://www.ensembl.org/id/ENSBTAT00000017095.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017095.5", "url": "https://www.ensembl.org/id/ENSBTAP00000017095.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514673", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514673", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480PI58-1", "protein_name": "Glycerophosphodiester phosphodiesterase domain containing 2", "gene_name": "GDPD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": 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"url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MCV1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MCV1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MCV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCV1" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 42, "end_pos": 44 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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"table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MCY6-1", "uniprot_ac": "F1MCY6", "uniprot_id": "F1MCY6_BOVIN", "mass": { "chemical_mass": 35421.0, "monoisotopic_mass": 35421.0 }, "refseq": { "ac": "NP_001376994", "name": "olfactory receptor family 52 subfamily J member 1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376994" }, "gene_names": [ { "name": "OR52J1", "type": "recommended", "evidence": [ { "id": "F1MCY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCY6" } ] }, { "name": "OR52J1", "type": "synonym", "evidence": [ { "id": "NP_001376994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376994" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1MCY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCY6/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 52J3", "type": "synonym", "evidence": [ { "id": "NP_001376994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376994" } ] }, { "name": "olfactory receptor family 52 subfamily J member 1", "type": "synonym", "evidence": [ { "id": "NP_001376994", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376994" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MCY6", "url": "https://www.uniprot.org/uniprotkb/F1MCY6#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376994" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MCY6", "url": "https://www.uniprot.org/uniprotkb/F1MCY6#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MCY6", "url": "https://www.uniprot.org/uniprotkb/F1MCY6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR52J1", "url": "https://www.uniprot.org/uniprotkb/F1MCY6", "locus": { "chromosome": "15", "start_pos": 49811308, "end_pos": 49812264, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000051580", "url": "https://www.ensembl.org/id/ENSBTAG00000051580" } ] } } ], "crossref": [ { "id": "F1MCY6", "url": "https://alphafold.ebi.ac.uk/entry/F1MCY6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000051580", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051580", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "524658", "url": "https://www.ncbi.nlm.nih.gov/gene/524658", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524658", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524658", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MRPILLM", "url": "https://omabrowser.org/oma/group/MRPILLM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MCY6", "url": "https://www.orthodb.org/?gene=F1MCY6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR26450:SF77", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26450:SF77", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376994", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MCY6", "url": "https://www.uniprot.org/uniprotkb/F1MCY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCY6-1", "url": "https://www.uniprot.org/uniprotkb/F1MCY6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLHTNTSTFHPDTFFLVGIPGLEDVHVWISLPFCFTYLMALLGNATVLLIIWSDHTLRDPMFYFLVILSAIDLALSTSAVPRMLGIFWFDAHEISFSACVAQMFLIHTFTGMESAVLLAMAFDRYVAICAPLHYTTILTPRVLAGIGIGIIMRPILLMFPILYLTHHLPFCGARIIAHSYCEHMGIVKLACASIRINAIYGLFVASFLILDVALVGISYAYILHAVFRLPSRDARHKALNTCGSHVGVMCVFYTPSLFSFLTHRFGQKIPPYIHILVANLYVVIPPALNPIIYGVKTKQIRAHVSHAFSSKQGCFLSS", "length": 318, "header": "tr|F1MCY6-1|F1MCY6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR52J1 PE=3 SV=3 CANONICAL=F1MCY6-1" }, "isoforms": [ { "isoform_ac": "F1MCY6-1", "url": "https://www.uniprot.org/uniprotkb/F1MCY6/entry", "sequence": { "sequence": "MLHTNTSTFHPDTFFLVGIPGLEDVHVWISLPFCFTYLMALLGNATVLLIIWSDHTLRDPMFYFLVILSAIDLALSTSAVPRMLGIFWFDAHEISFSACVAQMFLIHTFTGMESAVLLAMAFDRYVAICAPLHYTTILTPRVLAGIGIGIIMRPILLMFPILYLTHHLPFCGARIIAHSYCEHMGIVKLACASIRINAIYGLFVASFLILDVALVGISYAYILHAVFRLPSRDARHKALNTCGSHVGVMCVFYTPSLFSFLTHRFGQKIPPYIHILVANLYVVIPPALNPIIYGVKTKQIRAHVSHAFSSKQGCFLSS", "length": 318, "header": "tr|F1MCY6-1|F1MCY6_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR52J1 PE=3 SV=3 CANONICAL=F1MCY6-1" }, "locus": { "chromosome": "15", "start_pos": 49812264, "end_pos": 49811311, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049875.4", "url": "https://www.ensembl.org/id/ENSBTAT00000049875.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046698.4", "url": "https://www.ensembl.org/id/ENSBTAP00000046698.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524658", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524658", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MCY6", "url": "https://www.uniprot.org/uniprotkb/F1MCY6" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1MCY6", "url": "https://www.uniprot.org/uniprotkb/F1MCY6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MCY6", "url": "https://www.uniprot.org/uniprotkb/F1MCY6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MCY6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 318, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MCY6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MCY6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MCY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCY6" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 293, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 44, "end_pos": 46 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MCZ2-1", "uniprot_ac": "F1MCZ2", "uniprot_id": "F1MCZ2_BOVIN", "mass": { "chemical_mass": 69192.0, "monoisotopic_mass": 69192.0 }, "refseq": { "ac": "XP_005211436", "name": "transmembrane 9 superfamily member 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211436" }, "gene_names": [ { "name": "TM9SF1", "type": "recommended", "evidence": [ { "id": "F1MCZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCZ2" } ] }, { "name": "TM9SF1", "type": "synonym", "evidence": [ { "id": "XP_005211436", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211436" } ] } ], "protein_names": [ { "name": "Transmembrane 9 superfamily member", "type": "recommended", "evidence": [ { "id": "F1MCZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCZ2/entry#names_and_taxonomy" } ] }, { "name": "transmembrane 9 superfamily member 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005211436", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211436" } ] } ], "function": [ { "annotation": "Plays an essential role in autophagy.", "evidence": [ { "database": "UniProtKB", "id": "F1MCZ2", "url": "https://www.uniprot.org/uniprotkb/F1MCZ2#function" }, { "database": "UniProtKB", "id": "ARBA00037688", "url": "https://www.uniprot.org/uniprotkb/ARBA00037688#function" }, { "database": "UniProtKB", "id": "A0ABI0NZC0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZC0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MCZ2", "url": "https://www.uniprot.org/uniprotkb/F1MCZ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TM9SF1", "url": "https://www.uniprot.org/uniprotkb/F1MCZ2", "locus": { "chromosome": "10", "start_pos": 20967158, "end_pos": 20962178, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002709", "url": "https://www.ensembl.org/id/ENSBTAG00000002709" } ] } } ], "crossref": [ { "id": "F1MCZ2", "url": "https://alphafold.ebi.ac.uk/entry/F1MCZ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002709", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002709", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "539478", "url": "https://www.ncbi.nlm.nih.gov/gene/539478", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004240", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004240", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LEVHWLS", "url": "https://omabrowser.org/oma/group/LEVHWLS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MCZ2", "url": "https://www.orthodb.org/?gene=F1MCZ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10766", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10766", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10766:SF177", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10766:SF177", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02990", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02990", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005211436", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211436", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NZC0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZC0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCZ2", "url": "https://www.uniprot.org/uniprotkb/F1MCZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MCZ2-1", "url": "https://www.uniprot.org/uniprotkb/F1MCZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTVLGHPRSWSCRWWPLLLLLLLTGREPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRVLCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTSAGSGDDFDQSDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPWYKSTLVHMTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGTVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD", "length": 606, "header": "tr|F1MCZ2-1|F1MCZ2_BOVIN Isoform 1 of Transmembrane 9 superfamily member OS=Bos taurus OX=9913 GN=TM9SF1 PE=3 SV=1 CANONICAL=F1MCZ2-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NZC0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZC0/entry", "sequence": { "sequence": "MAESLYEIRFRENVEKRVLCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTSAGSGDDFDQSDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPWYKSTLVHMTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGTVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD", "length": 519, "header": "tr|A0ABI0NZC0-1|A0ABI0NZC0_BOVIN Computationally mapped isoform of Transmembrane 9 superfamily member OS=Bos taurus OX=9913 GN=TM9SF1 PE=3 SV=1 CANONICAL=F1MCZ2-1" }, "locus": { "chromosome": "10", "start_pos": 20966900, "end_pos": 20962859, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138040.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138040.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105794.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105794.1" } ] } }, { "isoform_ac": "F1MCZ2-1", "url": "https://www.uniprot.org/uniprotkb/F1MCZ2/entry", "sequence": { "sequence": "MTVLGHPRSWSCRWWPLLLLLLLTGREPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRVLCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTSAGSGDDFDQSDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPWYKSTLVHMTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGTVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD", "length": 606, "header": "tr|F1MCZ2-1|F1MCZ2_BOVIN Isoform 1 of Transmembrane 9 superfamily member OS=Bos taurus OX=9913 GN=TM9SF1 PE=3 SV=1 CANONICAL=F1MCZ2-1" }, "locus": { "chromosome": "10", "start_pos": 20966900, "end_pos": 20962598, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003509.5", "url": "https://www.ensembl.org/id/ENSBTAT00000003509.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003509.3", "url": "https://www.ensembl.org/id/ENSBTAP00000003509.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SP11-1", "protein_name": "Transmembrane 9 superfamily member", "gene_name": "TM9SF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTVLGHLRSWSCRWLPLLLLLGTGREPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLNSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTSGGSGDDFEQGDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASLFDAPCRTKNIAREIPPQPWYKSTLIHMTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGVVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD", "length": 605 }, "evidence": [ { "id": "F1MCZ2", "url": "https://omabrowser.org/oma/group/F1MCZ2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HDD7-1", "protein_name": "Transmembrane 9 superfamily member", "gene_name": "Tm9sf1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTVLGHPRSWSCQCLPVLILLLGTGHGPGVEGVTHYKPGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKKILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRSDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETSSGGSSDDFDQGDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPWYKSTVIHMTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD", "length": 606 }, "evidence": [ { "id": "F1MCZ2", "url": "https://omabrowser.org/oma/group/F1MCZ2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O15321-1", "protein_name": "Transmembrane 9 superfamily member 1", "gene_name": "TM9SF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTSAGSGDDFDQGDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPWYKSTVIHMTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD", "length": 606 }, "evidence": [ { "id": "F1MCZ2", "url": "https://omabrowser.org/oma/group/F1MCZ2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54ZW0-1", "protein_name": "Putative phagocytic receptor 1b", "gene_name": "phg1b", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MRLQILLIYLICIIVSSIVLVESSNKHHFKENDEVPFYVNNVGPYSNPTETYEFYTLPFCKPSSISYKKTKLGEILQGDSAVLSDYQFPFKSSFENKQLCEYTLKKEDIEKFKKAIGEYYYAEMIYDDLPIFSFVGTVDDSDLTNIRYYLYNHIPFEFDYNGDQVIRVNIDTEHIKVIELSDQDEITLKLTYSAKWQPTEHEFSKRMDLYEEFFTKELEIHWLSVMNSFFLVVLLTAFLAIMIMKILKNDYSRYSKTDEEEDSDYQEDYGWKLVHGDVFRFPPYKNVFSAFYGIGWQFISIVCGILALSLFGMFYPNNGGNMYTAGIVLYALTSGISGYQSAKMYKNMGGNKWAWNIVLTATLFVAPLFIVVILSNTVAITWHSTVALPILTMIEVITIWLFVGFPLTVVGGIAGRRLSENFEAPCRTKNFPREVPPIQWYRRLPCQILIAGFLPFSAIYIELFYIFNSVWGHSTYTLYGILCLVFLILINVTVCITVALTYFQLSMEDHKWWWNSFINGGSTVVFIYMYSIYYYYYISHMYGLLQATFYFTYMLIVCFFFFILLGTVGFYSSLIFVKRIYRNLKSD", "length": 587 }, "evidence": [ { "id": "F1MCZ2", "url": "https://omabrowser.org/oma/group/F1MCZ2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q66HF2-1", "protein_name": "Transmembrane 9 superfamily member 1", "gene_name": "Tm9sf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTVLGHPRSWSCHCLPVLILLLGIGHGPRVEGVTHYKPGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRSDELLGLTHTYSVRWSETSVEHRSDRRRADDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETSSGGSSDDFDQGDNGWKIIHTDVFRFPPCRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPVTTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPCAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD", "length": 589 }, "evidence": [ { "id": "F1MCZ2", "url": "https://omabrowser.org/oma/group/F1MCZ2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DBU0-1", "protein_name": "Transmembrane 9 superfamily member 1", "gene_name": "Tm9sf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTVLGYPRSWSCHCLPVLILLLGIGHGPWVEGVTHYKPGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRSDELLGLTHTYSVRWSETSVEHRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETSSGGSSDDFDQGDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTSSLFSVPFFLTWSVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPWYKSTVIHMTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD", "length": 606 }, "evidence": [ { "id": "F1MCZ2", "url": "https://omabrowser.org/oma/group/F1MCZ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "autophagosome membrane", "id": "GO:0000421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "database": "UniProtKB", "id": "F1MCZ2", "url": "https://www.uniprot.org/uniprotkb/F1MCZ2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MCZ2", "url": "https://www.uniprot.org/uniprotkb/F1MCZ2" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "F1MCZ2", "url": "https://www.uniprot.org/uniprotkb/F1MCZ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein localization to membrane", "id": "GO:0072657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072657", "evidence": [ { "database": "UniProtKB", "id": "F1MCZ2", "url": "https://www.uniprot.org/uniprotkb/F1MCZ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 401, "end_pos": 403, "annotation": "n_glycosylation_sequon" }, { "start_pos": 437, "end_pos": 439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 559, "end_pos": 561, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MCZ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 606, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MCZ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MCZ2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 178, "end_pos": 180 }, { "start_pos": 401, "end_pos": 403 }, { "start_pos": 437, "end_pos": 439 }, { "start_pos": 559, "end_pos": 561 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MD13-1", "uniprot_ac": "F1MD13", "uniprot_id": "F1MD13_BOVIN", "mass": { "chemical_mass": 60488.0, "monoisotopic_mass": 60488.0 }, "refseq": { "ac": "XP_005221002", "name": "testicular cell adhesion molecule 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221002" }, "gene_names": [ { "name": "TCAM1", "type": "recommended", "evidence": [ { "id": "F1MD13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD13" } ] }, { "name": "TCAM1", "type": "synonym", "evidence": [ { "id": "XP_005221002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221002" } ] } ], "protein_names": [ { "name": "Intercellular adhesion molecule 3", "type": "recommended", "evidence": [ { "id": "F1MD13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD13/entry#names_and_taxonomy" } ] }, { "name": "testicular cell adhesion molecule 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005221002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221002" } ] } ], "function": [ { "annotation": "Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring apoptotic neutrophil phagocytosis by macrophages. Is also a ligand for integrin ITGAD/ITGB2. Ligand of CD209 on dendritic cells (DC) through an integrin-independent mechanism that requires Ca(2+) and that forms a first contact between DC and resting T cell, facilitating the downstream DC-T cell clustering process and DC-induced proliferation of resting T Cells.", "evidence": [ { "database": "UniProtKB", "id": "F1MD13", "url": "https://www.uniprot.org/uniprotkb/F1MD13#function" }, { "database": "UniProtKB", "id": "ARBA00094525", "url": "https://www.uniprot.org/uniprotkb/ARBA00094525#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MD13", "url": "https://www.uniprot.org/uniprotkb/F1MD13" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TCAM1", "url": "https://www.uniprot.org/uniprotkb/F1MD13", "locus": { "chromosome": "19", "start_pos": 48108406, "end_pos": 48100055, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024947", "url": "https://www.ensembl.org/id/ENSBTAG00000024947" } ] } } ], "crossref": [ { "id": "F1MD13", "url": "https://alphafold.ebi.ac.uk/entry/F1MD13", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024947", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024947", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "616168", "url": "https://www.ncbi.nlm.nih.gov/gene/616168", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003987", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003987", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013768", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013768", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048679", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048679", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SQSPQIW", "url": "https://omabrowser.org/oma/group/SQSPQIW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MD13", "url": "https://www.orthodb.org/?gene=F1MD13", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13771", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13771", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13771:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13771:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03921", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03921", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21146", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21146", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005221002", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221002", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MD13", "url": "https://www.uniprot.org/uniprotkb/F1MD13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MD13-1", "url": "https://www.uniprot.org/uniprotkb/F1MD13-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEMLLFGVWALLALIPDPGAPEERFEVSVWPDQALVKYGQSLMVNCSTTCPDPGPGGIETLLKKTQVGKGPQWKEFLLEDVTQNSILQCFFSCAGIQKDINLGITVYQPPEQVIVELQPAWVAVDEAFTVTCHVPSVTPLENLTLTLLQDDQELQRKNFRSLAMASQRAEVTISVKAQREDDRCNFSCRAELDLNSHGGGLFHSNSALQVLRIFEFSQSPQIRVSSLLEVGMAETVSCEVARVFPAEEVMIHMFLGDQELSPFLFWEGDTIWANATVRAMEIGDQELSCLTSLGPVEQKTSQPVYVYSFPPPILEIEEMYPLAGTEINVTCSGHILTSPSPTLRLQGAPDLPAPGEPAWLSLNASEEDDGRNLSCEASLEVQGQQLSKTTVIQLHVLYKPRFEESGCPGNQTWLEGMEQMLACVPKGNPTPVLICTWNGTVFDLEVPQKATQNHSRTYCCIATNQLGSVSKDVSVLVEGLDEGISSTVLVIIIVALGVGVITVALYLNYRPCKVERRKLPYRQKEKNKEEESQFAVQQAEKHNEHTC", "length": 547, "header": "tr|F1MD13-1|F1MD13_BOVIN Isoform 1 of Intercellular adhesion molecule 3 OS=Bos taurus OX=9913 GN=TCAM1 PE=3 SV=2 CANONICAL=F1MD13-1" }, "isoforms": [ { "isoform_ac": "F1MD13-1", "url": "https://www.uniprot.org/uniprotkb/F1MD13/entry", "sequence": { "sequence": "MEMLLFGVWALLALIPDPGAPEERFEVSVWPDQALVKYGQSLMVNCSTTCPDPGPGGIETLLKKTQVGKGPQWKEFLLEDVTQNSILQCFFSCAGIQKDINLGITVYQPPEQVIVELQPAWVAVDEAFTVTCHVPSVTPLENLTLTLLQDDQELQRKNFRSLAMASQRAEVTISVKAQREDDRCNFSCRAELDLNSHGGGLFHSNSALQVLRIFEFSQSPQIRVSSLLEVGMAETVSCEVARVFPAEEVMIHMFLGDQELSPFLFWEGDTIWANATVRAMEIGDQELSCLTSLGPVEQKTSQPVYVYSFPPPILEIEEMYPLAGTEINVTCSGHILTSPSPTLRLQGAPDLPAPGEPAWLSLNASEEDDGRNLSCEASLEVQGQQLSKTTVIQLHVLYKPRFEESGCPGNQTWLEGMEQMLACVPKGNPTPVLICTWNGTVFDLEVPQKATQNHSRTYCCIATNQLGSVSKDVSVLVEGLDEGISSTVLVIIIVALGVGVITVALYLNYRPCKVERRKLPYRQKEKNKEEESQFAVQQAEKHNEHTC", "length": 547, "header": "tr|F1MD13-1|F1MD13_BOVIN Isoform 1 of Intercellular adhesion molecule 3 OS=Bos taurus OX=9913 GN=TCAM1 PE=3 SV=2 CANONICAL=F1MD13-1" }, "locus": { "chromosome": "19", "start_pos": 48107348, "end_pos": 48102894, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034769.5", "url": "https://www.ensembl.org/id/ENSBTAT00000034769.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034654.3", "url": "https://www.ensembl.org/id/ENSBTAP00000034654.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A6HK25-1", "protein_name": "Intercellular adhesion molecule 1", "gene_name": "Tcam1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKMLLLGIWTLLALIPCPGTTEVLFQVSVHPNQALVEFGHSLTINCSTTCPDPGPSGIETFLKKTQLSKGSQWKEFLLEGITENSVLQCFFSCAGVQKDTALDITMYQPPEQVILDLQPEWVAIDEAFTVKCHVPSVAPLQSLTLTLLQGDQELHRKDFLSLSLVSQRAEVTVNVRAQRENDRHNFSCRAELDLSPHGGGLFHGSSATKQLRIFEFSQNPQILVPSLLEVGMAETMSCEVVRVFPAQEAVFRMFLEDQELSPFSSWKGDAAWASATIQAMETGDQELTCLVSVGPVEQKARKPVHVYSFPPPVLEIEDAYPQAGTDVNVTCSGHVLTSPSPTLRLQGSLNLSAPGEPAWLRFTAREEDDGRTLSCEASLVVQGQRLVKTTKIQLHVLYKPRFQESDCPGNQIWVEGMDQMLACIPEGNPIPALVCIWNGMTFDLEVPQKATQNHTGTYSCTATNSLGSVSKDIAVLVQGLHEGISSSTIFIIIIFTLGMAVITIALYLNYQPCKRNGRKRTHRQKEQNKGGERQFSDIQAEECHAHLC", "length": 548 }, "evidence": [ { "id": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MD96-1", "uniprot_ac": "F1MD96", "uniprot_id": "F1MD96_BOVIN", "mass": { "chemical_mass": 137210.0, "monoisotopic_mass": 137210.0 }, "refseq": { "ac": "XP_002693153", "name": "tripartite motif-containing protein 66 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693153" }, "gene_names": [ { "name": "TRIM66", "type": "recommended", "evidence": [ { "id": "F1MD96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD96" } ] }, { "name": "TRIM66", "type": "synonym", "evidence": [ { "id": "XP_002693153", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002693153" } ] } ], "protein_names": [ { "name": "Tripartite motif-containing protein 66", "type": "recommended", "evidence": [ { "id": "F1MD96", 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"database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 814, "start_aa": "Thr", "end_pos": 814, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr814", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": 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"https://www.ensembl.org/id/ENSBTAG00000031238" } ] } } ], "crossref": [ { "id": "F1MDF0", "url": "https://alphafold.ebi.ac.uk/entry/F1MDF0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031238", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031238", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "528041", "url": "https://www.ncbi.nlm.nih.gov/gene/528041", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006633", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006633", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012334", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012334", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045140", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045140", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:528041", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528041", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "INLWCDM", "url": "https://omabrowser.org/oma/group/INLWCDM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MDF0", "url": "https://www.orthodb.org/?gene=F1MDF0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14695", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14695", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14695:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14695:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13229", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13229", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23762", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23762", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001039755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039755", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MDF0", "url": "https://www.uniprot.org/uniprotkb/F1MDF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDF0-1", "url": "https://www.uniprot.org/uniprotkb/F1MDF0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASGSRLPEDAVRGVSPGQRGEKIVSALTGDLVMAAALKSAASPMRSVVASPRPVKGTAGREAARRRLQLLPGSQAEGPGQGPEEEEEEPLLSVPEEDEEARPLPPVCVFPMRGMWREEKVALYCDEVLQGYKAEDADDAMSKYLSEKLKLKDKWLGVWKANPELFFVKYEESSIPFVGILVEVTCKPSQSSSSCFNVTVSVAEPFSSNIANIPRDLVDEILEELEHSVSLLEVYPVEGQDSDLHDIALALEVVRFFYDFLWRDWDDEESCENYTALIEERINLWCDIQDGTIPGPIAQRFKKTLEKYKNKRVELIEYQSNIKEDPSAAEAVECWKKYYEIVMLCGLLKMWEDLRLRVHGPFFPRILRRRKGKRNFGKTITHIVAKVMTTDMVKDLSPDTLLQQHDDLDLALDSCYSGDTVVIFPGEYQAVNLALLTDDIVIKGIGKREEIMITSEPSHDSFVVSKADNVKLMHLSLIQQGTVDGIVVVESGHMTLENCVLKCEGTGVCVLTGAALTITDSEITGAQGAGVELYPGSVAILERNEIHHCNNLRTCDSSKSTLGGVNMKVLPAPKLKMTNNHIYNNNGYGVSILQPTEQFFIVAEEVLNKGAASGDKRDDNMLSKVMQNLNLEMNNNKIEANLKGDIRIVTS", "length": 651, "header": "tr|F1MDF0-1|F1MDF0_BOVIN Isoform 1 of Testicular spindle-associated protein SHCBP1L OS=Bos taurus OX=9913 GN=SHCBP1L PE=4 SV=2 CANONICAL=F1MDF0-1" }, "isoforms": [ { "isoform_ac": "F1MDF0-1", "url": "https://www.uniprot.org/uniprotkb/F1MDF0/entry", "sequence": { "sequence": "MASGSRLPEDAVRGVSPGQRGEKIVSALTGDLVMAAALKSAASPMRSVVASPRPVKGTAGREAARRRLQLLPGSQAEGPGQGPEEEEEEPLLSVPEEDEEARPLPPVCVFPMRGMWREEKVALYCDEVLQGYKAEDADDAMSKYLSEKLKLKDKWLGVWKANPELFFVKYEESSIPFVGILVEVTCKPSQSSSSCFNVTVSVAEPFSSNIANIPRDLVDEILEELEHSVSLLEVYPVEGQDSDLHDIALALEVVRFFYDFLWRDWDDEESCENYTALIEERINLWCDIQDGTIPGPIAQRFKKTLEKYKNKRVELIEYQSNIKEDPSAAEAVECWKKYYEIVMLCGLLKMWEDLRLRVHGPFFPRILRRRKGKRNFGKTITHIVAKVMTTDMVKDLSPDTLLQQHDDLDLALDSCYSGDTVVIFPGEYQAVNLALLTDDIVIKGIGKREEIMITSEPSHDSFVVSKADNVKLMHLSLIQQGTVDGIVVVESGHMTLENCVLKCEGTGVCVLTGAALTITDSEITGAQGAGVELYPGSVAILERNEIHHCNNLRTCDSSKSTLGGVNMKVLPAPKLKMTNNHIYNNNGYGVSILQPTEQFFIVAEEVLNKGAASGDKRDDNMLSKVMQNLNLEMNNNKIEANLKGDIRIVTS", "length": 651, "header": "tr|F1MDF0-1|F1MDF0_BOVIN Isoform 1 of Testicular spindle-associated protein SHCBP1L OS=Bos taurus OX=9913 GN=SHCBP1L PE=4 SV=2 CANONICAL=F1MDF0-1" }, "locus": { "chromosome": "16", "start_pos": 63985551, "end_pos": 63941697, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044231.5", "url": "https://www.ensembl.org/id/ENSBTAT00000044231.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041741.3", "url": "https://www.ensembl.org/id/ENSBTAP00000041741.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:528041", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:528041", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B1H291-1", "protein_name": "Testicular spindle-associated protein SHCBP1L", "gene_name": "Shcbp1l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESDPTTSEPEAAIGSDSSPVEQAILVSLRDSASAKGLMSPVRSVVASPRPVKGKAARRRLQLPPVSQAETGDEEPVPAVPENQEEAQPLPPICASPMRGMWRSEKVALYCDQVLQGSKAEDADEAMSKYLSEKLKVTDRWLGVWKSNPELFFEKYEEASIPFVGILVEVTCKPRQNLSSCFKVTVSVAEPFSSNIANIPRDLVDEVLGELEYSAPLLEVYPVEGQDADVRDIALALEVVRFFYDFLWRDWDDEENCENYTALIEERINLWCDIQDGTIPGPIAQRFKKTLEKYKNKRVELIEYQSNIKEDPSAAEAVECWKKYYEIVMLCGLLKMWEDLRLRVHGPFFPRILRRRKGKRDFGKTITHIVAKVMTTDMVKNLSSDTLLQQHDDLNLALDSCYSGDIVVIFPGEYQASNLALLTDDITIKGVGKREEIMITSEPSHDSFVVSKADSVKLMQLSLIQQGTVDGIVVVESGHLTLENCLLKCEGTGVCVLTGASLTITNSEITGAQGAGVELYPGSIAILEGNEIHHCNNLRTSDSSKSTLGGVNMKVLPAPKLKMTNNHIYNNNGYGVSILQPSEQFFIVAEAALNKGAASGDKKDDKMLSKVMQTLNVEMNNNRIEANSKGDIRIVTG", "length": 637 }, "evidence": [ { "id": "F1MDF0", "url": "https://omabrowser.org/oma/group/F1MDF0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LVT2-1", "protein_name": "Testicular spindle-associated protein SHCBP1L", "gene_name": "SHCBP1L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASGPRPAVPEDSVRTVSPGRRGEKTVSAPTGELEAAGTLKSVVSPVRSVVASPRRVKGKAGREAARRRLQLLSVSQAEGPGEGPDEKEEPLLSVLEEDDEEAQPLPPVCVSPTRGMWRDEKVALYCDGILQDCKAEEADDAMSKYLSEKLKLKDKWLGVWKTNPELFFVKYEEASIPFVGILVEVTCKPHQSSSSCFKVTVSVAEPFSSNIANIPRDLVDEILEELEHSVPLLEVYPVEGQDSDLHDIALALEVVRFFYDFLWRDWDDEESCENYTALIEERINLWCDIQDGTIPGPIAQRFKKTLEKYKNKRVELIEYQNNIKEDPSAAEAVECWKKYYEIVMLCGLLKMWEDLRLRVHGPFFPRILRRRKGKRDFGKTITHIVAKVMTTEMVKDLSSDTLLQQHDDLDLALDSCYSGDTVVIFPGEYQAVNLALLTDDIIIKGIGKREEIMITSEPSHDSFVVSKADNVKLMHLSLIQQGTVDGIVVVESGHMTLENCILKCEGTGVCVLTGAALTITDSEITGAQGAGVELYPGSIAILERNEIHHCNNLRTSDSSKSTLGGVNMKVLPAPKLKMTNNHIYNNNGYGVSILQPTEQFFIVAEEALNKGAASGDKKDDNMLSKVMQNLNLEMNNNKIEANLKGDIRIVTS", "length": 653 }, "evidence": [ { "id": "F1MDF0", "url": "https://omabrowser.org/oma/group/F1MDF0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3TTP0-1", "protein_name": "Testicular spindle-associated protein SHCBP1L", "gene_name": "Shcbp1l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESDATTSEPKASVGSDSSPAEQTVLATLRDSVAAPTRGFMSPVRSVVASPRPVKGKAARRRLQLPPVTQAETCDEEPVPAVPEDQEEAQPLPPIYASPMRGMWRSEKVALYCDQVLQGSKAEDAEEAMSRYLLEKLKAKDRWLGVWKSNPELFFEKYEEASIPFVGILVEVTCKPRQNLSSCFKVTVSVAEPFSSNIANIPRDLVDEVLGELEYSAPLLEVYPVDGQDADVRDIALALEVVRFFYDFLWRDWDDEENCENYTALIEERINLWCDIQDGTIPGPIAQRFKKTLEKYKNKRVELIEYQSNIKEDPSAAEAVECWKKYYEIVMLCGLLKMWEDLRLRVHGPFFPRILRRRKGKRDFGKTITHIVAKVMTTDMVKNLSSDTLLQQHNDLNLALDSCYSGDIVVIFPGEYQASNLALLTDDITIKGVGKREEIMITSEPSHDSFVVSKADNVKLMQLSLIQQGTVDGIVVVESGHLTLENCLLKCEGTGVCVLTGASLTITNSEITGAQGAGVELYPGSIAILEGNEIHHCNNLRTSDSSKSTLGGVNMKVLPAPKLKMTNNHIYNNNGYGVSILQPSEQFFIVAEAALNKGAASGDKKDDKMLSKVMQTLNVEMNNNRIEANLKGDIRIVTG", "length": 639 }, "evidence": [ { "id": "F1MDF0", "url": "https://omabrowser.org/oma/group/F1MDF0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BZQ2-3", "protein_name": "Testicular spindle-associated protein SHCBP1L", "gene_name": "SHCBP1L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASGSKASVPADSFRTISPDRRGEKSASAVSGDTAAATTLKGTAIPVRSVVASPRPVKGKAGRETARLRLQRLPAAQAEDTGEAAAAAAEEPLLPVPEDEEEAQPLPPVCVSRMRGMWRDEKVSLYCDEVLQDCKAEDADEVMGKYLSEKLKLKDKWLGVWKTNPSVFFVKYEEASIPFVGILVEVTCEPYQDSSSRFKVTVSVAEPFSSNIANIPRDLVDEILEELEHSVPLLEVYPVEGQDTDIHVIALALEVVRFFYDFLWRDWDDEESCENYTALIEERINLWCDIQDGTIPGPIAQRFKKTLEKYKNKRVELIEYQSNIKEDPSAAEAVECWKKYYEIVMLCGLLKMWEDLRLRVHGPFFPRILRRRKGKREFGKTITHIVAKMMTTEMIKDLSSDTLLQQHGDLDLALDNCYSGDTVIIFPGEYQAANLALLTDDIIIKGVGKREEIMITSEPSRDSFVVSKADNVKLMHLSLIQQGTVDGIVVVESGHMTLENCILKCEGTGVCVLTGAALTITDSEITGAQGAGVELYPGSIAILERNEIHHCNNLRTSNSSKSTLGGVNMKVLPAPKLKMTNNHIYSNKGYGVSILQPMEQFFIVAEEALNKRASSGDKKDDKMLFKVMQNLNLEMNNNKIEANVKGDIRIVTS", "length": 653 }, "evidence": [ { "id": "F1MDF0", "url": "https://omabrowser.org/oma/group/F1MDF0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "positive regulation of chromosome organization", "id": "GO:2001252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001252", "evidence": [ { "database": "UniProtKB", "id": "F1MDF0", "url": "https://www.uniprot.org/uniprotkb/F1MDF0" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "F1MDF0", "url": "https://www.uniprot.org/uniprotkb/F1MDF0" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MDF0", "url": "https://www.uniprot.org/uniprotkb/F1MDF0" } ], "pmid": "" }, { "name": "male meiosis cytokinesis", "id": "GO:0007112", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007112", "evidence": [ { "database": "UniProtKB", "id": "F1MDF0", "url": "https://www.uniprot.org/uniprotkb/F1MDF0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "meiotic spindle", "id": "GO:0072687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072687", "evidence": [ { "database": "UniProtKB", "id": "F1MDF0", "url": "https://www.uniprot.org/uniprotkb/F1MDF0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" }, { "start_pos": 273, "end_pos": 275, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MDF0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 651, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MDF0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MDF0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MDF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF0" }, { "id": "SM00722", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00722" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Carbohydrate-binding/sugar hydrolysis", "eco_id": "ECO_0000259", "start_pos": 374, "end_pos": 534, "start_aa": "Arg", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 197, "end_pos": 199 }, { "start_pos": 273, "end_pos": 275 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MDI3-1", "uniprot_ac": "F1MDI3", "uniprot_id": "F1MDI3_BOVIN", "mass": { "chemical_mass": 34664.0, "monoisotopic_mass": 34664.0 }, "refseq": { "ac": "NP_001377544", "name": "olfactory receptor family 1 subfamily AB member 2", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377544" }, "gene_names": [ { "name": "OR1AB2", "type": "recommended", "evidence": [ { "id": "F1MDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDI3" } ] }, { "name": "OR1AB2", "type": "synonym", "evidence": [ { "id": "NP_001377544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377544" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1MDI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDI3/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 1 subfamily AB member 2", "type": "synonym", "evidence": [ { "id": "NP_001377544", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377544" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377544" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MDI3", "url": "https://www.uniprot.org/uniprotkb/F1MDI3#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MDI3", "url": "https://www.uniprot.org/uniprotkb/F1MDI3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR1AB2", "url": "https://www.uniprot.org/uniprotkb/F1MDI3", "locus": { "chromosome": "7", "start_pos": 6948006, "end_pos": 6948953, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039983", "url": "https://www.ensembl.org/id/ENSBTAG00000039983" } ] } } ], "crossref": [ { "id": "F1MDI3", "url": "https://alphafold.ebi.ac.uk/entry/F1MDI3", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd15918", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15918", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "789246", "url": "https://www.ncbi.nlm.nih.gov/gene/789246", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:789246", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789246", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NVMVYTV", "url": "https://omabrowser.org/oma/group/NVMVYTV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MDI3", "url": "https://www.orthodb.org/?gene=F1MDI3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377544", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MDI3", "url": "https://www.uniprot.org/uniprotkb/F1MDI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDI3-1", "url": "https://www.uniprot.org/uniprotkb/F1MDI3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEIGANLTLVSEFLLLGLSEDPKQQRLLFILFLSMYLVTQLGNLSIILAIATDVRLHTPMYFFLANLAFVDICFTSTTIPKMLANHVSGHKGIPYAGCLAQMFFFIWFAGIDSFLLTTMAYDRYKAICHPLHYALSVTPQLCSVLVAASWTAAFGNALTHTVLLTRLSFCTHNQIPHFFCDLSPLLKLACSDTFLNNAVVYTVGALPIITPFVGILVSYTRIFAAVLRIPSTRGKRKAFSTCGSHLSVVSLFYGTIIGVYFSPMSSHAAQKDTAAAVMYTVVTPMLNPFIYSLRNSDMKGALGALISRRPVFIQ", "length": 315, "header": "tr|F1MDI3-1|F1MDI3_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR1AB2 PE=3 SV=3 CANONICAL=F1MDI3-1" }, "isoforms": [ { "isoform_ac": "F1MDI3-1", "url": "https://www.uniprot.org/uniprotkb/F1MDI3/entry", "sequence": { "sequence": 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"Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TPRRGYM", "url": "https://omabrowser.org/oma/group/TPRRGYM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MDI5", "url": "https://www.orthodb.org/?gene=F1MDI5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22752", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22752", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22752:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22752:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": 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receptor 101 OS=Bos taurus OX=9913 GN=GPR101 PE=3 SV=2 CANONICAL=F1MDI5-1" }, "isoforms": [ { "isoform_ac": "F1MDI5-1", "url": "https://www.uniprot.org/uniprotkb/F1MDI5/entry", "sequence": { "sequence": "MASTCTNSTRENNSSHACMPLSKMPISLAHGIIRSSVLLIFLTASFVGNIVLAFVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVVATSVPIFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPAKMTPRRGYLLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWGASPSYTIVSVVSFIVIPLIVMIACYSVVFGAARRQHALLYNVKSHSLEVRAKDRVENENEEGGKKDEFQSESEFHGQDEGEVKAKVDSEEAMEGSKKAKKGSVETGEGSMEATGSEEVRESNSLVAKGSTKIQSSRKADKGRLEVTQCNIDLGEDDLEFGEDDLHFNEDDIEAVNIPESLPVSRRNSNGDPPLPRCYQCKAAKVIFLIIFSYVLSLGPYCFLAVLAVWVDVQTKVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDMLKKFFCKEKPPKENSHPDLPGTEAGTEGGTEGKIVPSHDSATSP", "length": 503, "header": "tr|F1MDI5-1|F1MDI5_BOVIN Isoform 1 of G protein-coupled receptor 101 OS=Bos taurus OX=9913 GN=GPR101 PE=3 SV=2 CANONICAL=F1MDI5-1" }, "locus": { "chromosome": "X", "start_pos": 20584815, "end_pos": 20583307, "strand": "+", "evidence": [ { "database": "Ensembl 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"MASTCTNSTRENNSSHACLPLSKMPISLAHGIIRSSVLLIFLTASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVVATSMPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPAKMTPRRGYMLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWGASPSYTVLSVVSFIIIPLSVMIACYSVVFGAARRQHALLYNVKSHSLEVRAKDRVENENEKEGGKDAFQGESEFHGQGEGDVKAKEGSVEAEGSEEAREGSLAAGKGSTEGKEGGPTIESSKKADQGRAEVSQCSIDLGEDDVEFGEEDINFNEEDIEAVNIPESLPASRRNSNGDPPLPRCYQCKAAKVIFLIIFSYVLSLGPYCFLAVLAVWVDVQTKVPQWVITIIIWLFFLQCCIHPYIYGYMHKTIKKEIQDMLRKFFCKEKPRKEDSHPDLPGTEAGTEPGTEGKTVPSHDSATSP", "length": 489 }, "evidence": [ { "id": "F1MDI5", "url": "https://omabrowser.org/oma/group/F1MDI5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4ABK4-1", "protein_name": "G protein-coupled receptor 101", "gene_name": "Gpr101", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSSCTNSTQENNSSRVCLPLSKMPISIAHGIIRSVVLLIILGVAFVGNVVLGYVLHRKPHLLQVTNRFIFNLLVTDLLQVALVAPWVVSTAIPFFWPLNIHFCTALVSLTHLFAFASVNTIVVVSIDRYLSIIHPLSYPSKMTNRRSYILLYGTWIAAFLQSTPPLYGWGHATFDDRNAFCSMIWGDSPAYTVVSVVSFLVIPLGVMIACYSVVFGAARRQQALLYKAKSHRFQVRVKDSVVHENEQGAKRDECQDENEFEDQDEGGQESTSMLDEGAMVAENSSMKTGAGSLDFCASILAAMGSEEVSNGSMEGLELSTEIQASSAKANTDRRDVNQCNIYVGEDDVEFGMDEIHFNEDDVEAMRIPESRPPSRRNSTSNPPLPPCYECKAARVIFIIIFSYVLSLGPYCFLAVLAVWVDIDSQVPQWVITIIIWLFFLQCCVHPYVYGYMHKSIKKEIKEVLKKLTCKKSTSVDDSHPELRETEAGTEGGTEGKAIPSHDSATSP", "length": 508 }, "evidence": [ { "id": "F1MDI5", "url": "https://omabrowser.org/oma/group/F1MDI5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80T62-1", "protein_name": "Probable G protein-coupled receptor 101", "gene_name": "Gpr101", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPPSCTNSTQENNGSRVCLPLSKMPISVAHGIIRSVVLLVILGVAFLGNVVLGYVLHRKPNLLQVTNRFIFNLLVTDLLQVALVAPWVVSTAIPFFWPLNIHFCTALVSLTHLFAFASVNTIVVVSVDRYLTIIHPLSYPSKMTNRRSYILLYGTWIAAFLQSTPPLYGWGHATFDDRNAFCSMIWGASPAYTVVSVVSFLVIPLGVMIACYSVVFGAARRQQALLYKAKSHRLEVRVEDSVVHENEEGAKKRDEFQDKNEFQGQDGGGQAEAKGSSSMEESPMVAEGSSQKTGKGSLDFSAGIMEGKDSDEVSNGSMEGLEVITEFQASSAKADTGRIDANQCNIDVGEDDVEFGMDEIHFNDDVEAMRIPESSPPSRRNSTSDPPLPPCYECKAARVIFVIISTYVLSLGPYCFLAVLAVWVDIDTRVPQWVITIIIWLFFLQCCIHPYVYGYMHKSIKKEIQEVLKKLICKKSPPVEDSHPDLHETEAGTEGGIEGKAVPSHDSATSP", "length": 511 }, "evidence": [ { "id": "F1MDI5", "url": "https://omabrowser.org/oma/group/F1MDI5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96P66-1", "protein_name": "Probable G protein-coupled receptor 101", "gene_name": "GPR101", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSTCTNSTRESNSSHTCMPLSKMPISLAHGIIRSTVLVIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVVATSVPLFWPLNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIVAILQSTPPLYGWGQAAFDERNALCSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVFCAARRQHALLYNVKRHSLEVRVKDCVENEDEEGAEKKEEFQDESEFRRQHEGEVKAKEGRMEAKDGSLKAKEGSTGTSESSVEARGSEEVRESSTVASDGSMEGKEGSTKVEENSMKADKGRTEVNQCSIDLGEDDMEFGEDDINFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQCKAAKVIFIIIFSYVLSLGPYCFLAVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVYGYMHKTIKKEIQDMLKKFFCKEKPPKEDSHPDLPGTEGGTEGKIVPSYDSATFP", "length": 508 }, "evidence": [ { "id": "F1MDI5", "url": "https://omabrowser.org/oma/group/F1MDI5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MDI5", "url": "https://www.uniprot.org/uniprotkb/F1MDI5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MDI5", "url": "https://www.uniprot.org/uniprotkb/F1MDI5" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "F1MDI5", "url": "https://www.uniprot.org/uniprotkb/F1MDI5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "positive regulation of MAPK cascade", "id": "GO:0043410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043410", "evidence": [ { "database": "UniProtKB", "id": "F1MDI5", "url": "https://www.uniprot.org/uniprotkb/F1MDI5" } ], "pmid": "" }, { "name": "adenylate cyclase-activating adrenergic receptor signaling pathway", "id": "GO:0071880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071880", "evidence": [ { "database": "UniProtKB", "id": "F1MDI5", "url": "https://www.uniprot.org/uniprotkb/F1MDI5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 13, "end_pos": 15, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MDI5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 503, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MDI5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MDI5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MDI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDI5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 445, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 13, "end_pos": 15 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", 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"count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MDL7-1", "uniprot_ac": "F1MDL7", "uniprot_id": "F1MDL7_BOVIN", "mass": { "chemical_mass": 106679.0, "monoisotopic_mass": 106679.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Coiled-coil domain containing 187", "type": "recommended", "evidence": [ { "id": "F1MDL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDL7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MDL7", "url": "https://www.uniprot.org/uniprotkb/F1MDL7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/F1MDL7", "locus": {} } ], "crossref": [ { "id": "F1MDL7", "url": "https://alphafold.ebi.ac.uk/entry/F1MDL7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023064", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023064", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR028750", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028750", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13958", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13958", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13958:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13958:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MDL7", "url": "https://www.uniprot.org/uniprotkb/F1MDL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDL7-1", "url": "https://www.uniprot.org/uniprotkb/F1MDL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MV92", "url": "https://www.uniprot.org/uniprotkb/F1MV92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MV92-1", "url": "https://www.uniprot.org/uniprotkb/F1MV92-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "KESQRQCPVSLRAAGGRAFRRASAKSRLCPLAAEDDAMAAVKWPEPRRQAGALWGSPAAAWSDHTEEPGRRGQVCSVPMWLTDEEAKDGDSSVSSGRLSGSSGGHESCTPPHRTWTERAPQVPRPPRQPRESNPRLEQLRDKIRAQAQRQASCASLGTSTPSSASYLYKAPAPAPRRKARKPSNPPPAPAYPGQWGSSLQGQAGRGEKVMRLGQSAQEKTKRMKSNSCKTEKAPKPPAPRRAAKDTGRVEPRWGVSRGALRLLATPRLPVFADHGKKVGATESSPVHPQTPSPASVHSDLQMPSDNVPTLASRDPPVNVQAAMAVLRDLRQQIQAGLELARTRHTSRGLELHGLAGRRRPGPWKPPDVRGAFWKSPGAPTDRLPTSERAGSLPAAQRWSPVAGWESYPHRTWVAPGRDTSFQRCVSPTEGPNSFPQRPWSASARQASCPPKTWAFQGRDPSLQRPGSPPERWVPFLQRSWSASAGQAWGPQRAWTACEDPADPAPRPWSPLERPSQPTWRPWSTSFTQGPSPLYQGRGPLRTPSGAKLAWPRPSQGALRNAPEKENEVRPPRPCPKPRGALGPLHGSESLREFMRQKTAAWRRQALEEKASAMRSLELRNQRLQGAHRKQREAVLGRAVPVVSQTTPGIVTFVPHAAQSRDLEAAAGPGAPVLQWSKVTSGMVLGDQEAPGSFCLCLNRALNPTKTLEVGGPQDGWEGTPLLMPASSSLGPLKFQDLSTNCQSPGLCIYLDPEESERLGMPGPLHFRYKQARLQALETMANILKQRIDVLTDKLRRSEAMDALVGPGPGLLPSSSSTPACPGALVPNVGQGVPGDWAGLQARPLLCTPGFLDTETVRWSPGWERLQSASPRARHVSEPIGFMDDGRSELDGRLARNVASFQALSPFAGSSLGVPATPDPRGGSLRLEETHSARGAGLVAPWTLRSCGKGEPVDRPWAGWSGGQGGPLGTPSTRSFLMWSIPTRRY", "length": 985, "header": "tr|F1MDL7-1|F1MDL7_BOVIN Isoform 1 of Coiled-coil domain containing 187 OS=Bos taurus OX=9913 GN= PE=4 SV=5 CANONICAL=F1MDL7-1" }, "isoforms": [ { "isoform_ac": "F1MDL7-1", "url": "https://www.uniprot.org/uniprotkb/F1MDL7/entry", "sequence": { "sequence": "KESQRQCPVSLRAAGGRAFRRASAKSRLCPLAAEDDAMAAVKWPEPRRQAGALWGSPAAAWSDHTEEPGRRGQVCSVPMWLTDEEAKDGDSSVSSGRLSGSSGGHESCTPPHRTWTERAPQVPRPPRQPRESNPRLEQLRDKIRAQAQRQASCASLGTSTPSSASYLYKAPAPAPRRKARKPSNPPPAPAYPGQWGSSLQGQAGRGEKVMRLGQSAQEKTKRMKSNSCKTEKAPKPPAPRRAAKDTGRVEPRWGVSRGALRLLATPRLPVFADHGKKVGATESSPVHPQTPSPASVHSDLQMPSDNVPTLASRDPPVNVQAAMAVLRDLRQQIQAGLELARTRHTSRGLELHGLAGRRRPGPWKPPDVRGAFWKSPGAPTDRLPTSERAGSLPAAQRWSPVAGWESYPHRTWVAPGRDTSFQRCVSPTEGPNSFPQRPWSASARQASCPPKTWAFQGRDPSLQRPGSPPERWVPFLQRSWSASAGQAWGPQRAWTACEDPADPAPRPWSPLERPSQPTWRPWSTSFTQGPSPLYQGRGPLRTPSGAKLAWPRPSQGALRNAPEKENEVRPPRPCPKPRGALGPLHGSESLREFMRQKTAAWRRQALEEKASAMRSLELRNQRLQGAHRKQREAVLGRAVPVVSQTTPGIVTFVPHAAQSRDLEAAAGPGAPVLQWSKVTSGMVLGDQEAPGSFCLCLNRALNPTKTLEVGGPQDGWEGTPLLMPASSSLGPLKFQDLSTNCQSPGLCIYLDPEESERLGMPGPLHFRYKQARLQALETMANILKQRIDVLTDKLRRSEAMDALVGPGPGLLPSSSSTPACPGALVPNVGQGVPGDWAGLQARPLLCTPGFLDTETVRWSPGWERLQSASPRARHVSEPIGFMDDGRSELDGRLARNVASFQALSPFAGSSLGVPATPDPRGGSLRLEETHSARGAGLVAPWTLRSCGKGEPVDRPWAGWSGGQGGPLGTPSTRSFLMWSIPTRRY", "length": 985, "header": "tr|F1MDL7-1|F1MDL7_BOVIN Isoform 1 of Coiled-coil domain containing 187 OS=Bos taurus OX=9913 GN= PE=4 SV=5 CANONICAL=F1MDL7-1" }, "locus": { "chromosome": "11", "start_pos": 103769262, "end_pos": 103748133, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031357.6", "url": "https://www.ensembl.org/id/ENSBTAT00000031357.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031312.6", "url": "https://www.ensembl.org/id/ENSBTAP00000031312.6" } ] } }, { "isoform_ac": "F1MV92-1", "url": "https://www.uniprot.org/uniprotkb/F1MV92/entry", "sequence": { "sequence": "QRQVQAVFMPTQVHVSVATPSLGGAKVVLCPLAAEDDAMAAVKWPEPRRQAGALWGSPAAAWSDHTEEPGRRGQVCSVPMWLTDEEAKDGDSSVSSGRLSGSSGGHESCTPPHRTWTERAPQVPRPPRQPRESNPRLEQLRDKIRAQAQRQASCASLGTSTPSSASYLYKAPAPAPRRKARKPSNPPPAPAYPGQWGSSLQGQAGRGEKVMRLGQCRPGPKTKRMKSNSCKTEKAPKPPAPRRAAKDTGRKVGATESSPVHPQTPSPASVHSDLQMPSDNVPTLASRDPPVNVQAAMAVLRDLRQQIQAGLELARTRHTSRGLELHGLAGRRRPGPWKPPDVRGAFWKSPGAPTDRLPTSERAGSLPAAQRWSPVAGWESYPHRTWVAPGRDTSFQRCVSPTEGPNSFPQRPWSASARQASCPPKTWAFQGRDPSLQRPGSPPERWVPFLQRSWSASAGQAWGPQRAWTACEDPADPAPRPWSPLERPSQPTWRPWSTSFTQGPSPLYQGRGPLRTPSGAKLAWPRPSQGALRNAPEKENEVRPPRPCPKPRGALGPLHGSESLREFMRQKTAAWRRQALEEKASAMRSLELRNQRLQGAHRKQREAVLGRAVPVVSQTTPGIVTFVPHAAQSRVCGTAAGPGAPVLQWSKVTSGMVLGDQEAPGSFCLCLNRESERLGMPGPLHFRYKQARLQALETMANILKQRIDVLTDKLRRSEAMDALVGPGPGLLPSSSSTPACPGALVPNVGQGVPGDWAGLQARPLLCTPGFLDTETVRWSPGWERLQSASPRARHVSEPIGRATPRPSTPWASGPSPSPSLGLRSPWTLGLQEPSLLALPQPPAVSCLEGVHCSHGCLCISSSLGVPATPDPRGGSLRLEETHSARGAGLVAPWTLRSCGKGEPVDRPWAGWSGGQGGPLGTPSTA", "length": 925, "header": "tr|F1MV92-1|F1MV92_BOVIN Computationally mapped isoform of Coiled-coil domain containing 187 OS=Bos taurus OX=9913 GN= PE=4 SV=5 CANONICAL=F1MDL7-1" }, "locus": { "chromosome": "11", "start_pos": 103769197, "end_pos": 103748199, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000057004.5", "url": "https://www.ensembl.org/id/ENSBTAT00000057004.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000047863.5", "url": "https://www.ensembl.org/id/ENSBTAP00000047863.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 428, "start_aa": "Thr", "end_pos": 428, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr428", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], 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"end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr916", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 969, "start_aa": "Thr", "end_pos": 969, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr969", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-9013106", "name": "", "url": 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"length": 1104, "header": "tr|F1MDM5-1|F1MDM5_BOVIN Isoform 1 of Voltage-gated delayed rectifier potassium channel KCNH8 OS=Bos taurus OX=9913 GN=KCNH8 PE=3 SV=3 CANONICAL=F1MDM5-1" }, "locus": { "chromosome": "1", "start_pos": 156841776, "end_pos": 156340497, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017003.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017003.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017003.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017003.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 238, "start_aa": "Thr", "end_pos": 238, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr238", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100336609", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336609", "resource": "KEGG Pathway" }, { "id": "R-BTA-1296072", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "resource": "Reactome", "description": "Voltage gated Potassium channels" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N2X3-1", "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH8", "gene_name": "Kcnh8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELSGFARTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKIEFKGEIMFYKKNGSLFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKITSEDKKEDRAKGRSRTGTHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNEDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTMGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSAVSQAESKGNGSINRRLPSIVEDEEEEEEVEEEETASLSPIYTKRSSVSRSKKIGGNKSYLGLNLKQLASGTVPFHSPIRVSTANSPKTKQEAEPSSHGRRIEKNLKVQLGSMTSSGTPELSPRIVDGIEDGNSNEETQTFDFGSEQIRPEPRISPPLGDPDIGAGVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNIMQLLENILSPQQPSRFCSLHPTPMCPSKESLQMRMSWSAHQPCLHFQTGGAQLYHGNVTSDIWSMDPSSLGSSPQRTVAHEQNPADSELHLSPKLDYSPSHCQVIQEGHLQFLRCISPHSDSTLTPLQSISTTLSSSVSSSSETSLHRVLPSRSEEGSITHRPVSSFSLENLPGSWDQEAMMSSSTETLENFPVEVVTSTADSKDSKAINL", "length": 1103 }, "evidence": [ { "id": "F1MDM5", "url": "https://omabrowser.org/oma/group/F1MDM5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1P320-1", "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH8", "gene_name": "KCNH8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCDLAGFARTEVMQKSCSCKFLLGAETNEQMILQIEKSLEEKVEFKGEIMFYKKNGSSFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKIAAEDKKEEKWKGRGRAGSHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGHDELSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKREMEQNNPLTWDIGWLHELGKRIESPYYDNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSTVLAILGKGDLIGANLSIRDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNLREGHESDVISKLSNKSTLSQTELKGNGNIKKKLPSIVEDEEDDEEGEEESSTLSPIHTRSTTFPQQKAGSNKSHLGRNLKQLASGTVPFHSPIRACSSNSSRTKHETELHYYSRRREKNLKLHLSALNSGGPPDLSPRIVDGTEDGNHTEESQTFDFSSDQLRQESRASPTIGEAEIGAAVLVIKAEETKQQISRLNNEVTNLTQEVSQLSKDMKNVIYLLENLLPSQKPSGFCTVHGISRSPTLESLQAQMAWTTRQPCTHMQAGNITCTKAQPCRSNTLCDIWNTDLSSVGSSPQRTEHNLQNSTDSEFFYTSGLHNSPSQYQVIQKDNFQFLRCTSPHSDTTLTPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSFSQGAISSLSLENLPGSWDLEGAGGTVSAQISDFPLDTVTSTRDVKEKDNQAIDV", "length": 1108 }, "evidence": [ { "id": "F1MDM5", "url": "https://omabrowser.org/oma/group/F1MDM5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P59111-1", "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH8", "gene_name": "Kcnh8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKVEFKGEIMFYKKNGAPFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKITSEDKKEDRTKGRSRAGSHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKASDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNEDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSTVSQAEPKGNGSINKRLPSIVEDEEEEEVEEEETTSLSPIYTRGSSVSHSKKTGSNKTYLGLSLKQLASGTVPFHSPIRVSSANSPKTKQEADPPNHGRKKEKNLKVQLSSLGSAGTPELSPRIVDGIEDGNSNEETQTFDFGSEQIRPEPRISPPLAESEIGAAFLFIKAEETKQQINKLNSEVTTLTQEVSQLGRDMRSIMQLLENILSPQQPSQFCSLHPTPMCPSRESLQTRVSWSAHQPCLHLQAGGAHLYHGNVASGIWSVDPSLVGSSPQRTEAHEQNPADSELHHSPNLDYSPSHCQVIQEGHLQFLRCISPHSDTTLTPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSITHGPVSSFSLENLPGSWDREQMMSASSERLENFPVEVVTSTADVKDSKAINV", "length": 1102 }, "evidence": [ { "id": "F1MDM5", "url": "https://omabrowser.org/oma/group/F1MDM5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96L42-1", "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH8", "gene_name": "KCNH8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGEEEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFHSPIRVSRSNSPKTKQEIDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSEESQTFDFGSERIRSEPRISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLSPQQPSRFCSLHSTSVCPSRESLQTRTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWSVDPSSVGSSPQRTGAHEQNPADSELYHSPSLDYSPSHYQVVQEGHLQFLRCISPHSDSTLTPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSFSQGTVSSFSLENLPGSWNQEGMASASTKPLENLPLEVVTSTAEVKDNKAINV", "length": 1107 }, "evidence": [ { "id": "F1MDM5", "url": "https://omabrowser.org/oma/group/F1MDM5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QWS8-1", "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH8", "gene_name": "Kcnh8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKVEFKGEIMFYKKNGAPFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKITSEDKKEDRAKGRSRAGSHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNEDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSTVPQAEPKGNGSIKKRLPSIVEDEEEEEVEEEETTSLSPIYTRGSSVSHSKKTGSSKSYLGLSLKQLTSGTVPFHSPIRVSSANSPKTKQEADPPNHGTRKEKNLKVQLCSLGTAGTPELSPRIVDGIEDGNSSEETQTFDFGSEQIRPEPRISPSLGESEIGAAFLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRSIMQLLENILSPQQPSQFCSLHPTSICPSRESFQTRVSWSAHQPCLHLQANGAHLYHGNVTSDIWSVDPSLVGSNPQRTEAHEQSPVDSELHHSPNLAYSPSHCQVIQEGHLQFLRCISPHSDTTLTPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSITHGPVSSFSLENLPGSWDREGMMSASTEPLENFPVEVVTSTADVKDSKAINV", "length": 1102 }, "evidence": [ { "id": "F1MDM5", "url": "https://omabrowser.org/oma/group/F1MDM5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "delayed rectifier potassium channel activity", "id": "GO:0005251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005251", "evidence": [ { "database": "UniProtKB", "id": "F1MDM5", "url": "https://www.uniprot.org/uniprotkb/F1MDM5" } ], "pmid": "" }, { "name": "voltage-gated potassium channel activity", "id": "GO:0005249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "database": "UniProtKB", "id": "F1MDM5", "url": "https://www.uniprot.org/uniprotkb/F1MDM5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MDM5", "url": "https://www.uniprot.org/uniprotkb/F1MDM5" } ], "pmid": "" }, { "name": "monoatomic ion channel complex", "id": "GO:0034702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034702", "evidence": [ { "database": "UniProtKB", "id": "F1MDM5", "url": "https://www.uniprot.org/uniprotkb/F1MDM5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of membrane potential", "id": "GO:0042391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042391", "evidence": [ { "database": "UniProtKB", "id": "F1MDM5", "url": "https://www.uniprot.org/uniprotkb/F1MDM5" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "F1MDM5", "url": "https://www.uniprot.org/uniprotkb/F1MDM5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 320, "end_pos": 322, "annotation": "n_glycosylation_sequon" }, { "start_pos": 409, "end_pos": 411, "annotation": "n_glycosylation_sequon" }, { "start_pos": 439, "end_pos": 441, "annotation": "n_glycosylation_sequon" }, { "start_pos": 468, "end_pos": 470, "annotation": "n_glycosylation_sequon" }, { "start_pos": 617, "end_pos": 619, "annotation": "n_glycosylation_sequon" }, { "start_pos": 687, "end_pos": 689, "annotation": "n_glycosylation_sequon" }, { "start_pos": 699, "end_pos": 701, "annotation": "n_glycosylation_sequon" }, { "start_pos": 820, "end_pos": 822, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29463", "name": "", "equation": "K(+)(in) = K(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "29463", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29463" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MDM5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1104, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MDM5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MDM5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MDM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDM5" }, { "id": "PS50042", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50042" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclic nucleotide-binding", 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"o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MDN8-1", "uniprot_ac": "F1MDN8", "uniprot_id": "F1MDN8_BOVIN", "mass": { "chemical_mass": 83496.0, "monoisotopic_mass": 83496.0 }, "refseq": {}, "gene_names": [ { "name": "GNL2", "type": "recommended", "evidence": [ { "id": "F1MDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDN8" } ] } ], "protein_names": [ { "name": "Nucleolar GTP-binding protein 2", "type": "recommended", "evidence": [ { "id": "F1MDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDN8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.", "evidence": [ { "database": "UniProtKB", "id": "F1MDN8", "url": "https://www.uniprot.org/uniprotkb/F1MDN8#function" }, { "database": "UniProtKB", "id": "ARBA00054763", "url": "https://www.uniprot.org/uniprotkb/ARBA00054763#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MDN8", "url": "https://www.uniprot.org/uniprotkb/F1MDN8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GNL2", "url": "https://www.uniprot.org/uniprotkb/F1MDN8", "locus": { "chromosome": "3", "start_pos": 108329376, "end_pos": 108305146, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000003849", "url": "https://www.ensembl.org/id/ENSBTAG00000003849" } ] } } ], "crossref": [ { "id": "F1MDN8", "url": "https://alphafold.ebi.ac.uk/entry/F1MDN8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003849", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003849", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01858", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01858", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024929", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024929", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050755", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050755", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KNPEDHI", "url": "https://omabrowser.org/oma/group/KNPEDHI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MDN8", "url": "https://www.orthodb.org/?gene=F1MDN8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11089", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11089", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11089:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11089:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01926", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01926", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08153", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08153", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MDN8", "url": "https://www.uniprot.org/uniprotkb/F1MDN8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDN8-1", "url": "https://www.uniprot.org/uniprotkb/F1MDN8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVKPKYKGRSTINPSNASTNPDRVQGAGGHNMRDRATIRRLNMYRQKERRNSRGKVIKPLQYQSTVASGTVARVEPNIKWFGNTRVIKQSSLQKFQEEMDTVLKDPYKVVMKQSKLPMSLLHDRIRPHNAKVHILDTESFETTFGPKAQRKRPNLFASDMQSLIENAETSTESYDQGKDRDLVAEDTGVRNEAQEEIFKKGQSKRIWGELYKVIDSSDVVVQVLDARDPVGTRSPHIETYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTLAFHASLTNPFGKGAFIQLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKTPEDHIGAVLERAKPEYISKTYKINSWENAEDFLEKLAFRTGKLLKGGEPNLRTVGKMVLNDWQRGRIPFFVKPPNAEPPAAPELPSSSSLEVAAETTQNNPGEKVTETVGEESESILEKEKEEPRHCGIDSEMQQILARVRQNFGKINVAPQFSGDDLVPLEMSDIDDELESLSAENEEEEEQEYPGDDEDESYAESQEEHAGRTTKAVIQALDEKIAKYQRFLNKAKAKKFSAIRISKGLSEMVFAKSEGRKKGKAEEDVDDTAPPKKGKKRKAQREEEQPDKTRRTLTSKERRREARQQRSRKVGIRYYETHNVKNRNRNKKKTTDSEGQKHRHKKAKHKQ", "length": 732, "header": "tr|F1MDN8-1|F1MDN8_BOVIN Isoform 1 of Nucleolar GTP-binding protein 2 OS=Bos taurus OX=9913 GN=GNL2 PE=3 SV=1 CANONICAL=F1MDN8-1" }, "isoforms": [ { "isoform_ac": "F1MDN8-1", "url": "https://www.uniprot.org/uniprotkb/F1MDN8/entry", "sequence": { "sequence": "MVKPKYKGRSTINPSNASTNPDRVQGAGGHNMRDRATIRRLNMYRQKERRNSRGKVIKPLQYQSTVASGTVARVEPNIKWFGNTRVIKQSSLQKFQEEMDTVLKDPYKVVMKQSKLPMSLLHDRIRPHNAKVHILDTESFETTFGPKAQRKRPNLFASDMQSLIENAETSTESYDQGKDRDLVAEDTGVRNEAQEEIFKKGQSKRIWGELYKVIDSSDVVVQVLDARDPVGTRSPHIETYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTLAFHASLTNPFGKGAFIQLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKTPEDHIGAVLERAKPEYISKTYKINSWENAEDFLEKLAFRTGKLLKGGEPNLRTVGKMVLNDWQRGRIPFFVKPPNAEPPAAPELPSSSSLEVAAETTQNNPGEKVTETVGEESESILEKEKEEPRHCGIDSEMQQILARVRQNFGKINVAPQFSGDDLVPLEMSDIDDELESLSAENEEEEEQEYPGDDEDESYAESQEEHAGRTTKAVIQALDEKIAKYQRFLNKAKAKKFSAIRISKGLSEMVFAKSEGRKKGKAEEDVDDTAPPKKGKKRKAQREEEQPDKTRRTLTSKERRREARQQRSRKVGIRYYETHNVKNRNRNKKKTTDSEGQKHRHKKAKHKQ", "length": 732, "header": "tr|F1MDN8-1|F1MDN8_BOVIN Isoform 1 of Nucleolar GTP-binding protein 2 OS=Bos taurus OX=9913 GN=GNL2 PE=3 SV=1 CANONICAL=F1MDN8-1" }, "locus": { "chromosome": "3", "start_pos": 108329346, "end_pos": 108305222, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005018.8", "url": "https://www.ensembl.org/id/ENSBTAT00000005018.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005018.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005018.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1VR06-1", "protein_name": "Nucleolar GTP-binding protein 2", "gene_name": "GNL2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVKPKYKGRSTINPSNASTNPDRVQGAGGQNMRDRATIRRLNMYRQKERRNSRGKVIKPLQYQSTVASGTVARVEPNIKWFGNTRVIKQSSLQKFQEEMDTVLKDPYKVVMKQSKLPMSLLHDRIRPHNSKVHILDTESFETTFGPKAQRKRPNLFASDMQSLIENAEMSTESYDQGKDRDLVAEDTGVRNEAQEEIYKKGQSKRIWGELYKVIDSSDVVVQVLDARDPMGTRSPHIETYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDHPTLAFHASLTNPFGKGAFIQLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKTPEDHIGAVLERAKPEYISKTYKIDSWENAEDFLEKLAFRTGKLLKGGEPDLRTVGKMVLNDWQRGRIPFFVKPPNAEPPATPQLPSASTLEVAPETAQNNTEEETPESGGGGSEPGLEKKEEEPGQCGADAEMQQILARVRQNFGKINVVPQFSGDDLVPLEMSDIEEELESLSGEREEEEEQEPQEDTDEEPFTEAQEEHTGSSTKAVIQALDEKIAKYQRFLDKAKAKKFSAVRISKGLSEKVFAKPEQQKAVEEDVEDTAPTKKGKKRKAQREEEHSDKTRRMLTSKERRRAARQQQPRKVGVRYYETHNVKNRNRNKKKTSDSEGQKQRRKKFKHKQ", "length": 730 }, "evidence": [ { "id": "F1MDN8", "url": "https://omabrowser.org/oma/group/F1MDN8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HE17-1", "protein_name": "Nucleolar GTP-binding protein 2", "gene_name": "Gnl2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MVKPKYKGRSTINRSAASTNPDRVQGAGGQNMRDRATIRRLNMYRQKERRNNRGKVIKPLQYQSTVASGTVARVEPNIKWFGNTRVIKQASLQKFQEEMDKVMKDPYKVVMKQSKLPMSLLHDRVQPHNAKVHILDTESFESTFGPKSQRKRPNLFASDMQSLLENAEMSTESYDQGKDRDLVTEDTGVRNEAQEEIYKKGQSKRIWGELYKVIDSSDVVVQVLDARDPMGTRSPHIEAYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSRDYPTLAFHASLTNPFGKGAFIQLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKAPQDHIGAVLERAKPEYISKTYKIDSWENAEDFLEKLAFRTGKLLKGGEPDLQTVGKMVLNDWQRGRIPFFVKPPNAEPPTAPQLPPSSPLEVPTEITENNPEEEISETIVEKSDSVIEKEPEADHPQDSNSEMQQILARVRQNFGKINVGPQFSADDLVPVELSDMEEDLESLSAEEEEQDQEQPGEDAEEAPSQDSQEEPVEKDTKAVIRALDEKIAKYQKFLNKAKAKKFSAIRISKDLSEKVFAKYEEEKKRSVEVSDAAPTKKGRKRSAHMEEEPSSKAQRMLTCKERRRAARQQQSKKVGVRYYETHNVKNRNRNKKKTNDSEGQKHRHKKLRQKQ", "length": 730 }, "evidence": [ { "id": "F1MDN8", "url": "https://omabrowser.org/oma/group/F1MDN8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q13823-1", "protein_name": "Nucleolar GTP-binding protein 2", "gene_name": "GNL2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVKPKYKGRSTINPSKASTNPDRVQGAGGQNMRDRATIRRLNMYRQKERRNSRGKIIKPLQYQSTVASGTVARVEPNIKWFGNTRVIKQSSLQKFQEEMDTVMKDPYKVVMKQSKLPMSLLHDRIRPHNLKVHILDTESFETTFGPKSQRKRPNLFASDMQSLIENAEMSTESYDQGKDRDLVTEDTGVRNEAQEEIYKKGQSKRIWGELYKVIDSSDVVVQVLDARDPMGTRSPHIETYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTLAFHASLTNPFGKGAFIQLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKSPEDHIGAVLERAKPEYISKTYKIDSWENAEDFLEKLAFRTGKLLKGGEPDLQTVGKMVLNDWQRGRIPFFVKPPNAEPLVAPQLLPSSSLEVVPEAAQNNPGEEVTETAGEGSESIIKEETEENSHCDANTEMQQILTRVRQNFGKINVVPQFSGDDLVPVEVSDLEEELESFSDEEEEEQEQQRDDAEESSSEPEEENVGNDTKAVIKALDEKIAKYQKFLDKAKAKKFSAVRISKGLSEKIFAKPEEQRKTLEEDVDDRAPSKKGKKRKAQREEEQEHSNKAPRALTSKERRRAVRQQRPKKVGVRYYETHNVKNRNRNKKKTNDSEGQKHKRKKFRQKQ", "length": 731 }, "evidence": [ { "id": "F1MDN8", "url": "https://omabrowser.org/oma/group/F1MDN8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99LH1-1", "protein_name": "Nucleolar GTP-binding protein 2", "gene_name": "Gnl2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVKPKYKGRSTINRSAASTNPDRVQGAGGQNMRDRGTIRRLNMYRQKERRNSRGKVIKPLQYQSTVASGTVARVEPNIKWFGNTRVIKQASLQKFQEEMDKVMKDPYKVVMKQSKLPMSLLHDRIQPHNAKVHILDTESFESTFGPKSQRKRPNLFASDMQSLLENAEMSTESYDQGKDRDLVMEDTGVRNEAQEEIYKKGQSKRIWGELYKVIDSSDVVVQVLDARDPMGTRSPHIEAYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTLAFHASLTNPFGKGAFIQLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKAPQDHIGAVLERAKPEYISKTYKIESWENAEDFLEKLALRTGKLLKGGEPDMLTVSKMVLNDWQRGRIPFFVKPPNAELPTDSQLPPSSPLEVPTETTQNNPEEETTETEVERSDSITEKEPEGDCSQDRNSEMQQILARVRQNFGKINVGPQFSADDLVPVEMSDLEDLESSGEEEEQEQEQPGEDAEEERSPDTQEEPVGNDTKAVLRALDEKIAKYQRFLNKAKAKKFSAVRISKDLSEKVFAKYKEEKKTSAEDSDAAPTKKARKWDAQMEEEPSNKTQRMLTCKERRRAARQQQSKKVGVRYYETHNVKNRNRNKKKTSDSEGQKHRRNKFRQKQ", "length": 728 }, "evidence": [ { "id": "F1MDN8", "url": "https://omabrowser.org/oma/group/F1MDN8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1MDN8", "url": "https://www.uniprot.org/uniprotkb/F1MDN8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1MDN8", "url": "https://www.uniprot.org/uniprotkb/F1MDN8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MDN8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 732, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MDN8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MDN8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDN8" }, { "id": "PS51721", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51721" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CP-type G", "eco_id": "ECO_0000259", "start_pos": 207, "end_pos": 368, "start_aa": "Trp", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 16, "end_pos": 18 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { 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"tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MDQ5-1", "uniprot_ac": "F1MDQ5", "uniprot_id": "F1MDQ5_BOVIN", "mass": { "chemical_mass": 54364.0, "monoisotopic_mass": 54364.0 }, "refseq": {}, "gene_names": [ { "name": "PIK3R3", "type": "recommended", "evidence": [ { "id": "F1MDQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDQ5" } ] } ], "protein_names": [ { "name": "Phosphatidylinositol 3-kinase regulatory subunit gamma", "type": "recommended", "evidence": [ { "id": "F1MDQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDQ5/entry#names_and_taxonomy" } ] }, { "name": "p55PIK", "type": "synonym", "evidence": [ { "id": "F1MDQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDQ5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. 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Classification" ] }, { "id": "IPR035022", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035022", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "KICHING", "url": "https://omabrowser.org/oma/group/KICHING/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10155", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10155", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10155:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10155:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16454", "url": 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"id": "R-BTA-912526", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-912526", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-912631", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-912631", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9927354", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9927354", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0ABI0P1G4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1G4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1G4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1G4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDQ5", "url": "https://www.uniprot.org/uniprotkb/F1MDQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDQ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MDQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAITNGIKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELISHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRKEGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNAWLGIKNEDADETYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYGSLKELVLHYQRTSLVQHNDSLNVRLAYPVHAQMPSLCR", "length": 461, "header": "tr|F1MDQ5-1|F1MDQ5_BOVIN Isoform 1 of Phosphatidylinositol 3-kinase regulatory subunit gamma OS=Bos taurus OX=9913 GN=PIK3R3 PE=3 SV=1 CANONICAL=F1MDQ5-1" }, "isoforms": [ { "isoform_ac": "A0ABI0P1G4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1G4/entry", "sequence": { "sequence": "MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAITNGIKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELISHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRKEGNEKEIERWLNHKGVRQKRLNAWLGIKNEDADETYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYGSLKELVLHYQRTSLVQHNDSLNVRLAYPVHAQMPSLCR", "length": 402, "header": "tr|A0ABI0P1G4-1|A0ABI0P1G4_BOVIN Computationally mapped isoform of Phosphoinositide-3-kinase regulatory subunit 3 OS=Bos taurus OX=9913 GN=PIK3R3 PE=3 SV=1 CANONICAL=F1MDQ5-1" }, "locus": { "chromosome": "3", "start_pos": 100063828, "end_pos": 99963094, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136482.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136482.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105042.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105042.1" } ] } }, { "isoform_ac": "F1MDQ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MDQ5/entry", "sequence": { "sequence": "MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAITNGIKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELISHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRKEGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNAWLGIKNEDADETYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYGSLKELVLHYQRTSLVQHNDSLNVRLAYPVHAQMPSLCR", "length": 461, "header": "tr|F1MDQ5-1|F1MDQ5_BOVIN Isoform 1 of Phosphatidylinositol 3-kinase regulatory subunit gamma OS=Bos taurus OX=9913 GN=PIK3R3 PE=3 SV=1 CANONICAL=F1MDQ5-1" }, "locus": { "chromosome": "3", "start_pos": 100063828, "end_pos": 99963094, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003878.8", "url": "https://www.ensembl.org/id/ENSBTAT00000003878.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003878.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003878.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-114604", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-114604", "resource": "Reactome", "description": "GPVI-mediated activation cascade" }, { "id": "R-BTA-1257604", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1257604", "resource": "Reactome", "description": "PIP3 activates AKT signaling" }, { "id": "R-BTA-1266695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1266695", "resource": "Reactome", "description": "Interleukin-7 signaling" }, { "id": "R-BTA-1433557", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1433557", "resource": "Reactome", "description": "Signaling by SCF-KIT" }, { "id": "R-BTA-1660499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660499", "resource": "Reactome", "description": "Synthesis of PIPs at the plasma membrane" }, { "id": "R-BTA-389357", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-389357", "resource": "Reactome", "description": "CD28 dependent PI3K/Akt signaling" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" }, { "id": "R-BTA-512988", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-512988", "resource": "Reactome", "description": "Interleukin-3, Interleukin-5 and GM-CSF signaling" }, { "id": "R-BTA-6811558", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811558", "resource": "Reactome", "description": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" }, { "id": "R-BTA-8853659", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8853659", "resource": "Reactome", "description": "RET signaling" }, { "id": "R-BTA-9009391", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9009391", "resource": "Reactome", "description": "Extra-nuclear estrogen signaling" }, { "id": "R-BTA-9013404", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013404", "resource": "Reactome", "description": "RAC2 GTPase cycle" }, { "id": "R-BTA-912526", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-912526", "resource": "Reactome", "description": "Interleukin receptor SHC signaling" }, { "id": "R-BTA-912631", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-912631", "resource": "Reactome", "description": "Regulation of signaling by CBL" }, { "id": "R-BTA-9927354", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9927354", "resource": "Reactome", "description": "Co-stimulation by ICOS" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1W4S4-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit gamma", "gene_name": "PIK3R3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPVTSAVTNGMKDGSSSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNAWLGIKNEDADETYFVNEEDENLPHYDEKTWFVEDVNRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR", "length": 461 }, "evidence": [ { "id": "F1MDQ5", "url": "https://omabrowser.org/oma/group/F1MDQ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3GYN9-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit gamma", "gene_name": "LOC100774067", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVTNGVKDSFISLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKLQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKNLQEFHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKVRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNAWLGIKNEDAESYFINEEDENLPHYDEKTWFVEDVNRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR", "length": 460 }, "evidence": [ { "id": "F1MDQ5", "url": "https://omabrowser.org/oma/group/F1MDQ5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q63789-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit gamma", "gene_name": "Pik3r3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPVTSAVTNGMKDCFVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGNYGFSEPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKNLQEFHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKDYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKVRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHRGVRQRRLNAWLGIKSEDTDESYFINEDDESLPHYDEKTWFVEDVNRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKPCVIYSPARGYGFAEPYNLYGSLKELVLHYQQTSLVQHNDSLNVTLAYPVHAQMPSLCR", "length": 461 }, "evidence": [ { "id": "F1MDQ5", "url": "https://omabrowser.org/oma/group/F1MDQ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q64143-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit gamma", "gene_name": "Pik3r3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTPAVTNGMKDSFISLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSEPLTFTSVVELINHYHHESLAQYNPKLDVKLTYPVSRFQQDQLVKEDNIDAVGKNLQEFHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKDYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKLRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHRGVRQRRLNAWLGIKNEDSDESYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPTLCR", "length": 461 }, "evidence": [ { "id": "F1MDQ5", "url": "https://omabrowser.org/oma/group/F1MDQ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7KTZ2-1", "protein_name": "Pi3K21B, isoform B", "gene_name": "Pi3K21B", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRPQAPGSLVDPNEDELRMAPWYWGRISREEAKSILHGKPDGSFLVRDALSMKGEYTLTLMKDGCEKLIKICHMDRKYGFIETDLFNSVVEMINYYKENSLSMYNKTLDITLSNPIVRAREDEESQPHGDLCLLSNEFIRTCQLLQNLEQNLENKRNSFNAIREELQEKKLHQSVFGNTEKIFRNQIKLNESFMKAPADAPSTEAGGAGDGANAAASAAANANARRSLQEHKQTLLNLLDALQAKGQVLNHYMENKKKEELLLERQINALKPELQILQLRKDKYIERLKGFNLKDDDLKMILQMGFDKWQQLYETVSNQPHSNEALWLLKDAKRRNAEEMLKGAPSGTFLIRARDAGHYALSIACKNIVQHCLIYETSTGFGFAAPYNIYATLKSLVEHYANNSLEEHNDTLTTTLRWPVLYWKNNPLQVQMIQLQEEMDLEYEQAATLRPPPMMGSSAPIPTSRSREHDVVDGTGSLEAEAAPASISPSNFSTSQ", "length": 496 }, "evidence": [ { "id": "F1MDQ5", "url": "https://omabrowser.org/oma/group/F1MDQ5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q92569-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit gamma", "gene_name": "PIK3R3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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taurus OX=9913 GN=OR4E1 PE=3 SV=3 CANONICAL=F1MDS8-1" }, "locus": { "chromosome": "10", "start_pos": 25535291, "end_pos": 25534347, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015827.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015827.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015827.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015827.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522609", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522609", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4AE91-1", "protein_name": "Olfactory receptor", "gene_name": "Or4e1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"evidence": [ { "id": "F1MDS8", "url": "https://omabrowser.org/oma/group/F1MDS8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P0C645-1", "protein_name": "Olfactory receptor 4E1", "gene_name": "OR4E1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEEAILLNQTSLVTYFRLRGLSVNHKARIAMFSMFLIFYVLTLIGNVLIVITIIYDHRLHTPMYFFLSNLSFIDVCHSTVTVPKMLRDVWSEEKLISFDACVTQMFFLHLFACTEIFLLTVMAYDRYVAICKPLQYMIVMNWKVCVLLAVALWTGGTIHSIALTSLTIKLPYCGPDEIDNFFCDVPQVIKLACIDTHVIEILIVSNSGLISVVCFVVLVVSYAVILVSLRQQISKGKRKALSTCAAHLTVVTLFLGHCIFIYSRPSTSLPEDKVVSVFFTAVTPLLNPIIYTLRNEEMKSALNKLVGRKERKEEK", "length": 315 }, "evidence": [ { "id": "F1MDS8", "url": "https://omabrowser.org/oma/group/F1MDS8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9R0K4-1", "protein_name": "Olfactory receptor", "gene_name": "Or4e1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"F1MDS8", "url": "https://www.uniprot.org/uniprotkb/F1MDS8" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "F1MDS8", "url": "https://www.uniprot.org/uniprotkb/F1MDS8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MDS8", "url": "https://www.uniprot.org/uniprotkb/F1MDS8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MDS8", "url": "https://www.uniprot.org/uniprotkb/F1MDS8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": 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"evidence": [ { "id": "NP_001243486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243486" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MDW9", "url": "https://www.uniprot.org/uniprotkb/F1MDW9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "P2RY4", "url": "https://www.uniprot.org/uniprotkb/F1MDW9", "locus": { "chromosome": "X", "start_pos": 80185847, "end_pos": 80184750, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040541", "url": "https://www.ensembl.org/id/ENSBTAG00000040541" } ] } } ], "crossref": [ { "id": "F1MDW9", "url": "https://alphafold.ebi.ac.uk/entry/F1MDW9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040541", "url": 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"MTSSESLLFTSPGPSQSSGDGGCKFNEEFKFILLPVSYAVVFVLGLALNAPTLWLFLFRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPFGTGFCKFVRFLFYWNLYCSVLFLTCISVHRYMGICHPLRALRWGRPRFASLLCLAVWLVVAGCLVPNLFFVTTSPNGTTILCHDTTRPEEFDHYVHFSSAVMVLLFGLPFLVTLVCYGLMARRLYRPLPGAGQSSSRLRSLRTIVVVLTVFAVCFVPFHITRTIYYLARLLKADCRVLNIVNVVYKVTRPLASANSCLDPVLYLFTGDKYRSQLQRLCRGSGPQPRTIASSLALVTLHEESSIRWADTHQDIIFPTYGGDRL", "length": 361 }, "evidence": [ { "id": "F1MDW9", "url": "https://omabrowser.org/oma/group/F1MDW9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O35811-1", "protein_name": "P2Y purinoceptor 4", "gene_name": "P2ry4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTSAESLLFTSLGPSPSSGDGDCRFNEEFKFILLPMSYAVVFVLGLALNAPTLWLFLFRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPFGTGLCKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRAIRWGRPRFASLLCLGVWLVVAGCLVPNLFFVTTNANGTTILCHDTTLPEEFDHYVYFSSAVMVLLFGLPFLITLVCYGLMARRLYRPLPGAGQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYQARLLQADCHVLNIVNVVYKVTRPLASANSCLDPVLYLFTGDKYRNQLQQLCRGSKPKPRTAASSLALVTLHEESISRWADTHQDSTFSAYEGDRL", "length": 361 }, "evidence": [ { "id": "F1MDW9", "url": "https://omabrowser.org/oma/group/F1MDW9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P51582-1", "protein_name": "P2Y purinoceptor 4", "gene_name": "P2RY4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKGTTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTPRADRL", "length": 365 }, "evidence": [ { "id": "F1MDW9", "url": "https://omabrowser.org/oma/group/F1MDW9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JJS7-1", "protein_name": "P2Y purinoceptor 4", "gene_name": "P2ry4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSADSLLFTSLGPSPSSGDGDCKFNEEFKFILLPLSYAVVFVLGLALNAPTLWLFLFRLRPWDATATYMFHLALSDTLYVLSLPTLVYYYAARNHWPFGTGFCKFVRFLFYWNLYCSVLFLTCISVHRYMGICHPLRAIRWGRPRFAGLLCLGVWLVVAGCLVPNLFFVTTNANGTTILCHDTTLPEEFDHYVYFSSTIMVLLFGFPFLITLVCYGLMARRLYRPLPGAGQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLNAECRVLNIVNVVYKVTRPLASANSCLDPVLYLFTGDKYRNQLQQLCRGSTPKRRTTASSLALVTLHEESISRWADIHQDSIFPAYEGDRL", "length": 361 }, "evidence": [ { "id": "F1MDW9", "url": "https://omabrowser.org/oma/group/F1MDW9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled UTP receptor activity", "id": "GO:0045030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045030", "evidence": [ { "database": "UniProtKB", "id": "F1MDW9", "url": "https://www.uniprot.org/uniprotkb/F1MDW9" } ], "pmid": "" }, { "name": "G protein-coupled purinergic nucleotide receptor activity", "id": "GO:0045028", "url": 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Expression" ] }, { "id": "IPR000911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020784", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020784", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020785", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020785", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036769", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036769", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036796", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036796", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CTIDNCH", "url": "https://omabrowser.org/oma/group/CTIDNCH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11661", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11661", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11661:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11661:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00298", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00298", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03946", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03946", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MDX5", "url": "https://www.uniprot.org/uniprotkb/F1MDX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDX5-1", "url": "https://www.uniprot.org/uniprotkb/F1MDX5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal membrane, lysosomal lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MDX6-1", "A0ABI0P643-1", "A0A3Q1NDQ7-1", "E1BCP9-1" ], "evidence": [ { "id": "R-BTA-1605624", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1605624" } ] }, { "id": "R-BTA-1606312", "name": "GLB1 hydrolyzes SapB/C:LacCer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MDX6-1", "A0ABI0P643-1", "A0A3Q1NDQ7-1", "E1BCP9-1" ], "evidence": [ { "id": "R-BTA-1606312", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1606312" } ] }, { "id": "R-BTA-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [ "R-ALL-2104997" ], "output_participant_list": [], "enzyme_list": [ "F1MDX6-1", "A0ABI0P643-1", "A0A3Q1NDQ7-1", "E1BCP9-1" ], "evidence": [ { "id": "R-BTA-1630306", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1630306" } ] }, { "id": "R-BTA-2090079", "name": "GLB1 hydrolyses linker chain(2)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [ "R-ALL-2090075" ], "output_participant_list": [ "R-ALL-2090063" ], "enzyme_list": [ "F1MDX6-1", "A0ABI0P643-1", "A0A3Q1NDQ7-1", "E1BCP9-1" ], "evidence": [ { "id": "R-BTA-2090079", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2090079" } ] }, { "id": "R-BTA-9840795", "name": "Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. 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taurus OX=9913 GN= PE=3 SV=3 CANONICAL=F1MDY8-1" }, "locus": { "chromosome": "10", "start_pos": 27320927, "end_pos": 27319711, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052685.3", "url": "https://www.ensembl.org/id/ENSBTAT00000052685.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050725.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050725.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287APN8-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100156611", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "DNFSSPGSVNGWSNKSVVTEFILLGLSSSQELQLFLFLIFSVFYGAAVLGNILIILIVITDSRLHSPMYFLLSNLSFIDVCQATFATPKMIADFLSEHKTITFQGCMSQIFFLHVFGGSEMVLLVAMAYDRYIAICKPLHYMTIMSRKVCAILVGVSWAIGILHSSSHLAFMVDLPFCGPNKVDNFFCDLPLVIKLACLDTYVLEILVLTNSGLLSLICFLLLLISYTVILATVHRQSPGGTSKALSTLSAHITVVVLFFGPLIFIYIWPFESFPIDKFISVFFTVFTPFLNPMIYTLRNKDVKEAMKKLRNQHVGSKEVF", "length": 321 }, "evidence": [ { "id": "F1MDY8", "url": "https://omabrowser.org/oma/group/F1MDY8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MDY8", "url": "https://www.uniprot.org/uniprotkb/F1MDY8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1MDY8", "url": "https://www.uniprot.org/uniprotkb/F1MDY8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MDY8", "url": "https://www.uniprot.org/uniprotkb/F1MDY8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "F1MDY8", "url": "https://www.uniprot.org/uniprotkb/F1MDY8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 65, "end_pos": 67, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MDY8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 312, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MDY8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MDY8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MDY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDY8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 287, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 65, "end_pos": 67 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { 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"https://www.ensembl.org/id/ENSBTAG00000018386" } ] } } ], "crossref": [ { "id": "F1MDZ0", "url": "https://alphafold.ebi.ac.uk/entry/F1MDZ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018386", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018386", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR010994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039150", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039150", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MDZ0", "url": "https://www.orthodb.org/?gene=F1MDZ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21053", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21053", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21053:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21053:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12836", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12836", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0ABI0P847", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P847", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P847-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P847-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDZ0", "url": "https://www.uniprot.org/uniprotkb/F1MDZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MDZ0-1", "url": "https://www.uniprot.org/uniprotkb/F1MDZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTVPSLLLAGGRWRCFPLPLASSLFQALHNSCCRKESTAPKKIIPHIDFSDETAKESGKTLDKLFSSEQQASILHVLNTASNKELEAFKLLRGKKSFNIVEHRKKFGPFQNLESLMNVPLFQYKITIQVCNSILNPETGGKKKKLQESRLLRKLIKPEIGRERVKAFLFQAVNSIVSIVSGTRRIAWAHLDRKLAVLDWQQTEYCQLMKGSYLSSVYLEEISSIISKMPKADFYVLEKAGPSFQNPSLFPVLLHFHMTEAMLYALLNTTFAQDGHHQVLSMNRNAVGKHFELMIGDTRTSGKEVVKQLLSESVLKDEPRVFFPPEKIVRYRQMFSSTEHNRVEELYDSLLQAIAFYELAVFNTES", "length": 365, "header": "tr|F1MDZ0-1|F1MDZ0_BOVIN Isoform 1 of Transcription elongation factor, mitochondrial OS=Bos taurus OX=9913 GN=TEFM PE=3 SV=4 CANONICAL=F1MDZ0-1" }, "isoforms": [ { "isoform_ac": "A0ABI0P847-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P847/entry", "sequence": { "sequence": "MTVPSLLLAGGRWRCFPLPLASSLFQALHNSCCRKESTAPKKIIPHIDFSDETAKESGKTLDKLFSSEQQASILHVLNTASNKELEAFKLLRGKKSFNIVEHRKKFGPFQNLESLMNVPLFQYKITIQVCNSILNPETGGKKKKLQESRLLRKLIKPEIGRERVKAVNSIVSIVSGTRRIAWAHLDRKLAVLDWQQTEYCQLMKGSYLSSVYLEEVRHLHLQILTCW", "length": 227, "header": "tr|A0ABI0P847-1|A0ABI0P847_BOVIN Computationally mapped isoform of Transcription elongation factor, mitochondrial OS=Bos taurus OX=9913 GN=TEFM PE=4 SV=1 CANONICAL=F1MDZ0-1" }, "locus": { "chromosome": "19", "start_pos": 18055026, "end_pos": 18052366, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000146261.1", "url": "https://www.ensembl.org/id/ENSBTAT00000146261.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107521.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107521.1" } ] } }, { "isoform_ac": "F1MDZ0-1", "url": "https://www.uniprot.org/uniprotkb/F1MDZ0/entry", "sequence": { "sequence": "MTVPSLLLAGGRWRCFPLPLASSLFQALHNSCCRKESTAPKKIIPHIDFSDETAKESGKTLDKLFSSEQQASILHVLNTASNKELEAFKLLRGKKSFNIVEHRKKFGPFQNLESLMNVPLFQYKITIQVCNSILNPETGGKKKKLQESRLLRKLIKPEIGRERVKAFLFQAVNSIVSIVSGTRRIAWAHLDRKLAVLDWQQTEYCQLMKGSYLSSVYLEEISSIISKMPKADFYVLEKAGPSFQNPSLFPVLLHFHMTEAMLYALLNTTFAQDGHHQVLSMNRNAVGKHFELMIGDTRTSGKEVVKQLLSESVLKDEPRVFFPPEKIVRYRQMFSSTEHNRVEELYDSLLQAIAFYELAVFNTES", "length": 365, "header": "tr|F1MDZ0-1|F1MDZ0_BOVIN Isoform 1 of Transcription elongation factor, mitochondrial OS=Bos taurus OX=9913 GN=TEFM PE=3 SV=4 CANONICAL=F1MDZ0-1" }, "locus": { "chromosome": "19", "start_pos": 18059398, "end_pos": 18052366, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024467.8", "url": "https://www.ensembl.org/id/ENSBTAT00000024467.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024467.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024467.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], 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"evidence": [ { "id": "F1ME12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME12" } ] }, { "name": "DSEL", "type": "synonym", "evidence": [ { "id": "NP_001193390", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193390" } ] } ], "protein_names": [ { "name": "Dermatan sulfate epimerase like", "type": "synonym", "evidence": [ { "id": "F1ME12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME12/entry#names_and_taxonomy" } ] }, { "name": "dermatan-sulfate epimerase-like protein precursor", "type": "synonym", "evidence": [ { "id": "NP_001193390", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193390" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1ME12", "url": "https://www.uniprot.org/uniprotkb/F1ME12" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DSEL", "url": "https://www.uniprot.org/uniprotkb/F1ME12", "locus": { "chromosome": "24", "start_pos": 9463257, "end_pos": 9444452, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000037907", "url": "https://www.ensembl.org/id/ENSBTAG00000037907" } ] } } ], "crossref": [ { "id": "ENSBTAG00000037907", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037907", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538958", "url": "https://www.ncbi.nlm.nih.gov/gene/538958", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008929", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008929", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032518", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032518", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052447", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052447", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538958", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538958", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WVITEEM", "url": "https://omabrowser.org/oma/group/WVITEEM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1ME12", "url": "https://www.orthodb.org/?gene=F1ME12", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15532", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15532", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15532:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15532:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00685", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00685", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16332", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16332", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2022923", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022923", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193390", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1ME12", "url": "https://www.uniprot.org/uniprotkb/F1ME12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME12-1", "url": "https://www.uniprot.org/uniprotkb/F1ME12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALMFTGHCLFLVLVMFAFSTLEESVSNYSDWAVFPDDIDPFKTQRVQDVRPNQKPKKSMLHPRLYFDAGEIQAMRQKSRTTHLHLFRAIRSAVTAMLSNPTYYLPPPKHADFAAKWNEIYGNNLPPLALYCLLCPEDKVAFEFALEYMDRMVGYKDWLVENAPGDEVPVGHSLTGFATAFDFLYNLLDGRRRQKYLEKIWVITEEMYEYSKVRSWGKQLLHNHQATNMIALLTGALVTGVDKGSKVNLWKQVVVDVMEKTMFLLNHIVDGSLDEGVAYGSYTAKSVTQYVFLAQRHFNINNLDNNWLKMHFWFYYATLLPGFQRTVGIADSNYNWFYGPESQLVFLDKFVLKNGAGNWLAQQIRRHRPKDGPMVPSTAQRWSTLHTEYIWYDPQLTPQPPAEYGTAKMHMFPNWGVVTYGAGLPNTQTNTFVSFKSGKLGGRAVYDIVHFQPYSWIDGWRSFNPGHEHPDQNSFTFAPNGQVFVSEALYGPKLSHLNNVLVFAPSPTSQCNKPWEGQLGECAQWLKWTGEEVGDAAGEIITASQHGDMIFVSGEAVSAYSSAMKLKSVYRALLLLNSQTLLVVDHVEKQEDSPIKSVSAFFHNLDIDFKYIPYRFMNRYNGALMDVWDAHYKMFWFDHRGSSPLASIQEAEQAAEFKKRWTQFVNVTFQMESAITRIAYVFYGPYVNVSSCRFIDNSNSGLQLSLNVNNTDHVVSIVTDYQNLKTRFDYLGFGGFATVADQAQVTRFGLGTEAIVKPIRRDRVIFPFGFKFNVAVGLILCIGLVILTFQWRFYLSFRKLMRWILILVIALWSVELLDVWSACTQPICAKWARPETEASGQALAPGGQRTDPPDVVITSLPGSGAEILKQLFFNSSDFLYIRVPTAYIDIPETELEIDSFVDACEWTASEVHGVRFRLLRGWLQSLVRDTKLHLQNIHLHEPSRGKLAQYFSMNKDKKRKLKRRESLAEQRSRMKGAFDRDAEYVRALRRHLVHYPSARPVLSLGSGSWTLKLHFFNEVLGASMRALYVVRDPRAWVYSMLYSSKPSLYSLKNVQEHLAKLFKTEGSAGRCTLNSGYAVEYELLRKELLASRPHPVSLLAHAWLANTAAALRLNADLLPTSYQLIKFEDLVHFPQNTTERIFAFLGIPLSPATLNQILFATSTNLFYLPYEGEISPANTNVWKRNLPKDEIKLIENICWTLMDRLGYPKFMD", "length": 1212, "header": "tr|F1ME12-1|F1ME12_BOVIN Isoform 1 of Dermatan sulfate epimerase like OS=Bos taurus OX=9913 GN=DSEL PE=3 SV=2 CANONICAL=F1ME12-1" }, "isoforms": [ { "isoform_ac": "F1ME12-1", "url": "https://www.uniprot.org/uniprotkb/F1ME12/entry", "sequence": { "sequence": "MALMFTGHCLFLVLVMFAFSTLEESVSNYSDWAVFPDDIDPFKTQRVQDVRPNQKPKKSMLHPRLYFDAGEIQAMRQKSRTTHLHLFRAIRSAVTAMLSNPTYYLPPPKHADFAAKWNEIYGNNLPPLALYCLLCPEDKVAFEFALEYMDRMVGYKDWLVENAPGDEVPVGHSLTGFATAFDFLYNLLDGRRRQKYLEKIWVITEEMYEYSKVRSWGKQLLHNHQATNMIALLTGALVTGVDKGSKVNLWKQVVVDVMEKTMFLLNHIVDGSLDEGVAYGSYTAKSVTQYVFLAQRHFNINNLDNNWLKMHFWFYYATLLPGFQRTVGIADSNYNWFYGPESQLVFLDKFVLKNGAGNWLAQQIRRHRPKDGPMVPSTAQRWSTLHTEYIWYDPQLTPQPPAEYGTAKMHMFPNWGVVTYGAGLPNTQTNTFVSFKSGKLGGRAVYDIVHFQPYSWIDGWRSFNPGHEHPDQNSFTFAPNGQVFVSEALYGPKLSHLNNVLVFAPSPTSQCNKPWEGQLGECAQWLKWTGEEVGDAAGEIITASQHGDMIFVSGEAVSAYSSAMKLKSVYRALLLLNSQTLLVVDHVEKQEDSPIKSVSAFFHNLDIDFKYIPYRFMNRYNGALMDVWDAHYKMFWFDHRGSSPLASIQEAEQAAEFKKRWTQFVNVTFQMESAITRIAYVFYGPYVNVSSCRFIDNSNSGLQLSLNVNNTDHVVSIVTDYQNLKTRFDYLGFGGFATVADQAQVTRFGLGTEAIVKPIRRDRVIFPFGFKFNVAVGLILCIGLVILTFQWRFYLSFRKLMRWILILVIALWSVELLDVWSACTQPICAKWARPETEASGQALAPGGQRTDPPDVVITSLPGSGAEILKQLFFNSSDFLYIRVPTAYIDIPETELEIDSFVDACEWTASEVHGVRFRLLRGWLQSLVRDTKLHLQNIHLHEPSRGKLAQYFSMNKDKKRKLKRRESLAEQRSRMKGAFDRDAEYVRALRRHLVHYPSARPVLSLGSGSWTLKLHFFNEVLGASMRALYVVRDPRAWVYSMLYSSKPSLYSLKNVQEHLAKLFKTEGSAGRCTLNSGYAVEYELLRKELLASRPHPVSLLAHAWLANTAAALRLNADLLPTSYQLIKFEDLVHFPQNTTERIFAFLGIPLSPATLNQILFATSTNLFYLPYEGEISPANTNVWKRNLPKDEIKLIENICWTLMDRLGYPKFMD", "length": 1212, "header": "tr|F1ME12-1|F1ME12_BOVIN Isoform 1 of Dermatan sulfate epimerase like OS=Bos taurus OX=9913 GN=DSEL PE=3 SV=2 CANONICAL=F1ME12-1" }, "locus": { "chromosome": "24", "start_pos": 9450256, "end_pos": 9446621, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120395.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120395.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074857.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074857.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538958", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538958", "resource": "KEGG Pathway" }, { "id": "R-BTA-2022923", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022923", "resource": "Reactome", "description": "DS-GAG biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AQA5-1", "protein_name": "Dermatan sulfate epimerase like", "gene_name": "DSEL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MALMFTGHFLFLVLVMFAFSTFEESVSNYSDWAVFTDDIDQFKTQKVQDIRPNQKLKKSMLHPHLYFDAGEIQAMRQKSRTSHVHLFRAIRSAVTVMLSNPTYYLPPPKHADFAAKWNEIYGNNLPPLALYCLLCPEDKVAFEFVLEYMDRMVGYKDWLVENAPGDEVPVGHSLTGFATAFDFLYNLLDDHRRQKYLGKIWAITEEMYEYSKVRSWGKQLLHNHQATNMIALLTGALVTGVDKGSQVNLWKQVVVDVMEKTMFLLNHIVDGSLDEGVAYGSYTAKSVTQYVFLAQRHFNINNLDNNWLKMHFWFYYATLLPGFQRTVGIADSNYNWFYGPESQLVFLDKFILKNGAGNWLAQQIRRHRPKDGPMVPSTAQRWSTLHTEYIWYDPQLTPQPPAEYGTAKLHTFPNWGVVTYGAGLPNTQTNTFVSFKSGKLGGRAVYDIVHFQPYSWIDGWRSFNPGHEHPDQNSFTFAPNGQVFVSEALYGPKLSHLNNVLVFAPSPTSQCNKPWEGQLGECAQWLKWTGEEVGDAAGEIITASQHGEMIFVSGEAVSAYSSAMKLKSVYRALLLLNSQTLLVVDHVERQNSSPIKSVSAFFHNLDIDFKYIPYRFMNRYNGAMMDVWDAHYKMFWFDHGGSSPIASIQEAEQAAEFKKRWTQFVNVTFQMDSTITRIAYIFYGPYVNVSSCRFIDNSNSGLQISLNVNNTEHTVSIVTDYNNLKTRFDYLGFGGFASVADQVQITRFGLGTQAIAKPIRRDRVIFPFGFKFNVAVGLVLCISLVVLTFQWRFYLSFRKLMRWILILVIALWFIELLDVWSTCTQPICAKWARMGAEASAKALSPNGHHVHLPDVVITSLPGSGAEILKQLFFNSSDFLYIRVPTAYIDIPETEFEIDSFVDACEWKAPDVHSVHFRLLRGWLQSLVQDTKLHLQNIHLHESSRGKLAQYFTTNKDKKRKLKRRESLLEQRSRMKGAFDRDAEYIRALRRHLVHYPSARPVLSLSSGSWTLKLHFFQEVLGASMRALYIVRDPRAWIYSMLYSSKPSLYSLKNVPEHLAKLLKIEGGKGQCNLNSGYASEYEALRKELSKPKPHAVSLLAHVWLANTAAALRINADLLPTSYQLVKFEDIVHFPQKIAERIFAFLGIPLSPASLNQILFATSTNLFYLPYEGEISPTNTNVWKQNLPREEIKLIENICWTLMERLGYPKFMD", "length": 1212 }, "evidence": [ { "id": "F1ME12", "url": "https://omabrowser.org/oma/group/F1ME12/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LMB8-1", "protein_name": "Dermatan-sulfate epimerase-like protein", "gene_name": "Dsel", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MALMFTGYFLFLTLMIFIFSTCEESVSNFSGWAVFTDDTEQFKNQKVQDFRSNQKLHPNLYFDAGDIQTMRQKSRTSHLHLFRAIRSAVTIMLSNPTYYLPPPKHADFAAKWNEIYGNNLPPLALYCLLCPEDKVAFEFVLEYMDRMVSYKDWLVENAPGDEVPVGHSLTGFATAFDFLYNLLGNQRKQKYLEKIQIVTEEMYEYSKIRSWGKQLLHNHQATNMIALLIGALVTGIDKGSKTNIWKQDVVDVMEKTMFLLNHIVDGSLDEGVAYGSYTSKSVTQYVFLAQRHFNINNLDNNWLKMHFWFYYATLLPGYQRTVGVADSNYNWFYGPESQLVFLDKFILRNGAGNWLAQQIRKHRPKDGPMVPSTAQRWSTLHTEYIWYDPKLTPQPPVDFGTAKMHTFPNWGVVTYGAGLPNTQTNTFVSFKSGKLGGRAVYDIVHFQPYSWIDGWRSFNPGHEHPDQNSFTFAPNGQVFVSEALYGPKFSHLNNVLVFAPSPSSQCNKPWEGQLGECAQWLKWTGEEAGDAAGEVITASQHGEMMFVSGEAVSAYSSAMRLKSVYRALLLLNSQTLLVVDHIERQETSPINSVSAFFHNLDIDFKYIPYRFMNRYNGAMMDVWDAHYKMFWFDHHGNTPVANIQEAEQAAEFKKRWTQFVNVTFHMESTITRIAYVFYGPYINVSSCRFIDSSSSGLQISLNVNNTEHSVSVVTDYQNLKSRFDYLGFGGFASVANQGQITRFGLGTQALVNPVRHDTVIFPFGFKFNIAVGFILCISLVILTFQWWFYLSFRKLMRCVLILVIALWFIELLDVWSTCTQPICAKWTRTESKANEKTLISEGKHVDLPDVVITSLPGSGAEILKQLFFNSSDFLYIRIPTAYIDIPETEFEIDSFVDACEWKVSDIHTGHFHLLRGWLLSLVQDTKLHLQNIHLHETSRNKLAQYFAANKDKKRKLKRRESLQEQRSRMKGAFDRDAEYIRALRRHLVYYPSARPVLSLSSGSWTLKLHFFQEVLGTSMRALYIIRDPRAWIYSMLYGSKPSLYSLKNVPEHLAKLFKIQEGKSKCSLNSGYAFEYESLKKELETSQSNTVSLLSHLWLANTAAAMRINTDLLPTSYQLVKFEDIVHFPQKTTERIFAFLGIPLSPASLNQILFATSTNLFYLPYEGEISPSNTNIWKQNLPRDEIKLIESICWTLMDRLGYPKFVD", "length": 1207 }, "evidence": [ { "id": "F1ME12", "url": "https://omabrowser.org/oma/group/F1ME12/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0X5K6-1", "protein_name": "Dermatan sulfate epimerase like", "gene_name": "DSEL", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALMLTGHTLFLALMMFAVFTFEESVSNYSDWVTFMENLDQYDKEKLDSLGAEQKVKKVSLHPSLYFDAEDVHVLRQKAHTSHSHIFRTIRSAVMVMLSNPMYYLPPPKYVDFAAKWNEVYGNNLPPLAFYCLLCPEDKAALDFTVEYMDRMAAYKNWLVESAPGDEVPLGHSLTGFATAYDFLYNSLEDVRRQKYLEKIRSASKEMFEYSKVRSWGKQLLHNHQATNMLALLTGALVTGVDDGSQANIWKHAVVDVMEKTMFLLNHIVDGSLDEGVAYGSYTAKSITQYVFLAQRHFGINNLENNWLKMHFWFYYATLLPGFQRTVGVADSNYNWFYGPESQLVFLDKFVLKNGAGNWLAQQIRKHRPKDGPMVPSTAQRWSTLHTEFIWYSAEITPQPPPDYGTAKMHVFPNWGVVTYGAGLPSSQTNTFVSFKSGKLGGRAVYDIVHFQPYAWIDGWRSFNPGHEHPDQNSFTFAPNGQVFVSEALYGPKLSHLNNVLVFAPSPTSQCNQPWEGQLGECAQWLKWIGHEVGDSSGEIITASQSGDMMFVSGEAVSAYTSAMKLKSVYRILLLLNSQTLLVVDHIEKEADSPVNSVSAFFHNLDIDFKYIPYKFKNKYNGAMMDVWDAHYKMFWFDHHGSSPVARIQEAEQAAEFKKRWTQFVNVTFPMKSTLTRIVYLFYGPYVNVSNCRLIDNVKSGFQISLSVNSTENTVSVVTDHQNLKARFDYLGFGGFAKVVHENKVTKFGLGTESVEKLIKNNRVVLPFGFKVNIIAGLILGVSLVILAFQWRFYVSFSKMLRWILILVITLWLTELVDVWSMCTQPICAKWSSDLTRLEHDEGNKDKRLEGTSIVFPDVIITSLPASGAEILKQLFFNSSDFLYMRIPTAYLEIPESEFEIDSFVDPCEWKASDVQNGHFHLLKGWLQSLVRDTKLHLQNIQLYEASRSKITQHSAINKDKKKRSKKRESLLEQRSRARASQEKDAEYIRELRRHLVYYPSARTVLSLSSGSWTLKLPFFQEILGPSMRALYVVRDPRAWIYSMLYKNKPSLYSLKKVPQRLAAMFKWENGKGKCSINEGYAFEYESLRKEFSNSNSNAVSVLSHLWLANTAAALRINGDLLPTNYLMVKFEDIVSFPQKTAETIFAFLGIPLPPASLNQILFATSTSLFYLPYEGEISPSSIHAWKQNMPKKEIRLIEDTCFSLMEHLGYPKFVE", "length": 1216 }, "evidence": [ { "id": "F1ME12", "url": "https://omabrowser.org/oma/group/F1ME12/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZYE3-1", "protein_name": "Dermatan sulfate epimerase-like", "gene_name": "Dsel", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALMFTGHLLFLTLMMCSFTTCEESVSNYSEWAVFTDDVQWFKTQKIQDFKLNQKLYPNLYFDAGDIQTMKQQSRTSHLHIFRAIKSAVTIMLSNPSYYLPPPKHAEFAAKWNEIYGNNLPPLALYCLLCPEDKVAFEFVMEYMDRMVSYKDWLVQNAPGDEVPLGHSLTGFATAFDFLYNLLGKQRKQKYLEKIWIVTEEMYEYSKIRSWGKQLLHNHQATNMIALLIGALVTGVDKGSKANIWKRVAVDEMEKTMFILNHIVDGSLDEGVAYGSYTSKSVTQYVFLAQRHFNISNFDNNWLKMHFWFYYATLLPGYQRTVGIADSNYNWFYGPESQLIFLDKFILRNGAGNWLAQQIRKHRPKDGPMVPSTAQRWSTLHTEYIWYDPTLPPQPPVDFGTAKMHTFPNWGVVTYGGGLPNTQTNTFVSFKSGKLGGRAVYDIVHFQPYSWIDGWKSFNPGHEHPDQNSFTFAPNGQVFVSEALYGPKLSHLNNVLVFAPSPSSQCNQPWEGQLGECAQWLKWTGEEVGDAAGEVIAAAQHGERMFVSGEAVSAYSSAMRLKSVYRALILLNSQTLLVVDHIERQETSPINSVSAFFHNLDIDFKYIPYRFMNRYNGAMMDVWDAHYKMFWFDHHGNSPVASIQEAEQAAEFKKRWTQFVNVTFHMESTITRIAYVFYGPYVNVSSCRFIDSSSSGLQISLYVNSTEHSVSVVTDYQNLKSRFRYLGFGGFASVANQGQITRFGLGTQAILNPVRHERVINFPFGFKFNIAVGFILCISLVILTFQWRFYLSFRKLMRCVLILVIALWLIELLDVWSTCTQPICAKWTRTEAKANEKVIISEGHHVDLPNVVITSLPGSGAEILKQLFFNSSDFLYIRIPTTYMDIPETEFEIDSFVDACEWKVSDIHSGQFHLLRGWLQSLVQDTKLHLQNIHLHETSRNKLVQYFTTNKDKKRKLKRRESLPDQRSRIKGSFDIDAEYIRALRRHLVYYPSARPVLSLSSGSWTLKLHFFQEVLGTSMRALYIVRDPRAWVYSMLYGSKPSLYSLKNVPDHLAKLFKIEEGKSKCNSNSGYAFEYESLKKELEIPQLNAVSLLSHLWVANTAAALRINTDLLPTNYHLVKFEDIVHFPQKTTERIFAFLGIPLSPASLNQILFATSTNLFYLPYEREISPSNTNIWKTNLPRNEIKLIENICWTLMDRLGYPKFMD", "length": 1208 }, "evidence": [ { "id": "F1ME12", "url": "https://omabrowser.org/oma/group/F1ME12/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q0VBN2-1", "protein_name": "Dermatan-sulfate epimerase-like protein", "gene_name": "Dsel", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAFMFTEHLLFLTLMMCSFSTCEESVSNYSEWAVFTDDIQWLKSQKIQDFKLNRRLHPNLYFDAGDIQTLKQKSRTSHLHIFRAIKSAVTIMLSNPSYYLPPPKHAEFAAKWNEIYGNNLPPLALYCLLCPEDKVAFEFVMEYMDRMVSYKDWLVENAPGDEVPVGHSLTGFATAFDFLYNLLGNQRKQKYLEKIWIVTEEMYEYSKIRSWGKQLLHNHQATNMIALLIGALVTGVDKGSKANIWKQVVVDVMEKTMFLLKHIVDGSLDEGVAYGSYTSKSVTQYVFLAQRHFNINNFDNNWLKMHFWFYYATLLPGYQRTVGIADSNYNWFYGPESQLVFLDKFILQNGAGNWLAQQIRKHRPKDGPMVPSTAQRWSTLHTEYIWYDPTLTPQPPVDFGTAKMHTFPNWGVVTYGGGLPNTQTNTFVSFKSGKLGGRAVYDIVHFQPYSWIDGWRSFNPGHEHPDQNSFTFAPNGQVFVSEALYGPKLSHLNNVLVFAPSPSSQCNQPWEGQLGECAQWLKWTGEEVGDAAGEVITAAQHGDRMFVSGEAVSAYSSAMRLKSVYRALLLLNSQTLLVVDHIERQETSPINSVSAFFHNLDIDFKYIPYKFMNRYNGAMMDVWDAHYKMFWFDHHGNSPVANIQEAEQAAEFKKRWTQFVNVTFHMESTITRIAYVFYGPYVNVSSCRFIDSSSSGLQISLHVNSTEHSVSVVTDYQNLKSRFSYLGFGGFASVANQGQITRFGLGTQEIVNPVRHDKVNFPFGFKFNIAVGFILCISLVILTFQWRFYLSFRKLMRCVLILVIALWFIELLDVWSTCTQPICAKWTRTEAKANEKVMISEGHHVDLPNVIITSLPGSGAEILKQLFFNSSDFLYIRIPTAYMDIPETEFEIDSFVDACEWKVSDIRSGHFHLLRGWLQSLVQDTKLHLQNIHLHETSRSKLAQYFTTNKDKKRKLKRRESLQDQRSRIKGPFDRDAEYIRALRRHLVYYPSARPVLSLSSGSWTLKLHFFQEVLGTSMRALYIVRDPRAWIYSVLYGSKPSLYSLKNVPEHLAKLFKIEEGKSKCNSNSGYAFEYESLKKELEISQSNAISLLSHLWVANTAAALRINTDLLPTNYHLVKFEDIVHFPQKTTERIFAFLGIPLSPASLNQMLFATSTNLFYLPYEGEISPSNTNIWKTNLPRDEIKLIENICWTLMDHLGYPKFMD", "length": 1207 }, "evidence": [ { "id": "F1ME12", "url": "https://omabrowser.org/oma/group/F1ME12/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IZU8-1", "protein_name": "Dermatan-sulfate epimerase-like protein", "gene_name": "DSEL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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] }, { "id": "IPR047514", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047514", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538955", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538955", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SCFPLHF", "url": "https://omabrowser.org/oma/group/SCFPLHF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1ME43", "url": "https://www.orthodb.org/?gene=F1ME43", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11829:SF204", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11829:SF204", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00250", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00250", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005218819", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218819", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1ME43", "url": "https://www.uniprot.org/uniprotkb/F1ME43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME43-1", "url": "https://www.uniprot.org/uniprotkb/F1ME43-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSHLFSPRLPALATSPMLYLYGPERPGLPLAFAPAGALAASGRVEPPQKPPYSYIALIAMAIQDAPEQRVTLNGIYQFIMDRFPFYHDNRQGWQNSIRHNLSLNDCFVKVPREKGRPGKGSYWTLDPRCLDMFENGNYRRRKRKPKPGPGGPEAKRVRAETQERGAEAPPEVQSAGGRPRPATPIQERAPARPSPLREASSPPPASLPWPRPGSPEGDAGDTLQGAAAVAVGQPERTVDGRGTPPRPASRSSPKSSDKSKSFSIDSILARRQGQKPTGGGELLGVAKQGPGGCLGASLLATSSSLRPPFNASLMLDPHVQGGFYQLGIPFLSYFPLQLPEAVLHFQ", 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"https://omabrowser.org/oma/group/F1ME43/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S6I8-1", "protein_name": "Forkhead box protein L2", "gene_name": "FOXL1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSHLFGPRLPALAASPMLYLYGPERPGLPLAFAPAAALAASGRAEPPQKPPYSYIALIAMAIQDAPGQRVTLSGIYQFIMDRFPFYHDNRQGWQNSIRHNLSLNDCFVKVPREKGRPGKGSYWTLDPRCLDMFENGNYRRRKRKPKPGPGAPEAKRARGPAQPEAGSGAERPRPATPRHEGAPARPPPLRAGASPSAPLHGPRPSSPEGNAGDALRGAGAEAAEQPARTADGRGSPPRPASGSSPKSSDKSKSFSIDSILAGRQGQKPAGGDELLGGPKPEPGGCLGASLLAASSSLCPPFNASLMLDPHVQGGFYQLGIPFLSYFPLQLPDTVLHFQ", "length": 338 }, "evidence": [ { "id": "F1ME43", "url": "https://omabrowser.org/oma/group/F1ME43/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q12952-1", "protein_name": "Forkhead box protein L1", "gene_name": "FOXL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"MSHLFSPPLAALAASPLLYVYSPERPGLPLAFAPAAALAGPGRVEPPQKPPYSYIALIAMAIQDAPEQRVTLNGIYQFIMDRFPFYHDNRQGWQNSIRHNLSLNECFVKVPREKGRPGKGSYWTLDPRCLDMFENGNYRRRKRKPKPAAGSPEAKRTRVEPPESEVGCDVGSPDLATALPTRAPDRSQSPAVGTARPALLPWPGPEPRDPDADLTVQGAGAVASGQLQRPAHHLGSPLCPAPSGSPKGSKSKSFSIDSILAVRPTPASGAEAPGIPKPVPGALGSSLLAASSGLAPPFNASLVFDAHVQGGFSQLGIPFLSYFPLQVPEATVLRFH", "length": 336 }, "evidence": [ { "id": "F1ME43", "url": "https://omabrowser.org/oma/group/F1ME43/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1ME43", "url": "https://www.uniprot.org/uniprotkb/F1ME43" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1ME43", "url": "https://www.uniprot.org/uniprotkb/F1ME43" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1ME43", "url": "https://www.uniprot.org/uniprotkb/F1ME43" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "F1ME43", "url": "https://www.uniprot.org/uniprotkb/F1ME43" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1ME43", "url": "https://www.uniprot.org/uniprotkb/F1ME43" } ], "pmid": "" }, { "name": "anatomical structure morphogenesis", "id": "GO:0009653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009653", "evidence": [ { "database": "UniProtKB", "id": "F1ME43", "url": "https://www.uniprot.org/uniprotkb/F1ME43" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1ME43", "url": "https://www.uniprot.org/uniprotkb/F1ME43" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1ME43", "url": "https://www.uniprot.org/uniprotkb/F1ME43" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 100, "end_pos": 102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1ME43-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 346, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1ME43-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ME43" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1ME43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME43" }, { "id": "PS50039", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50039" }, { "id": "PRU00089", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fork-head", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 143, "start_aa": "Lys", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 100, "end_pos": 102 }, { "start_pos": 310, "end_pos": 312 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 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"total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1ME65-1", "uniprot_ac": "F1ME65", "uniprot_id": "F1ME65_BOVIN", "mass": { "chemical_mass": 64530.0, "monoisotopic_mass": 64530.0 }, "refseq": { "ac": "XP_002687704", "name": "cytoskeleton-associated protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687704" }, "gene_names": [ { "name": "CKAP4", "type": "recommended", "evidence": [ { "id": "F1ME65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME65" } ] }, { "name": "CKAP4", "type": "synonym", "evidence": [ { "id": "XP_002687704", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687704" } ] } ], "protein_names": [ { "name": "Cytoskeleton associated protein 4", "type": "synonym", "evidence": [ { "id": "F1ME65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME65/entry#names_and_taxonomy" } ] }, { "name": "cytoskeleton-associated protein 4", "type": "synonym", "evidence": [ { "id": "XP_002687704", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687704" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1ME65", "url": "https://www.uniprot.org/uniprotkb/F1ME65" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CKAP4", "url": "https://www.uniprot.org/uniprotkb/F1ME65", "locus": { "chromosome": "5", "start_pos": 69630577, "end_pos": 69639143, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011913", "url": "https://www.ensembl.org/id/ENSBTAG00000011913" } ] } } ], "crossref": [ { "id": "F1ME65", "url": "https://alphafold.ebi.ac.uk/entry/F1ME65", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011913", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011913", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515784", "url": "https://www.ncbi.nlm.nih.gov/gene/515784", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "bta:515784", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515784", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GFSGWCV", "url": "https://omabrowser.org/oma/group/GFSGWCV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1ME65", "url": "https://www.orthodb.org/?gene=F1ME65", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45161", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45161", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45161:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45161:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5683826", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5683826", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696264", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9696270", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002687704", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687704", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1ME65", "url": "https://www.uniprot.org/uniprotkb/F1ME65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME65-1", "url": "https://www.uniprot.org/uniprotkb/F1ME65-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQHPPPPAPHPQQQHPPQHPQNQAHGKGGHRGGKSSSSAAAAAASSSASCSRRLGRVLNFLFYLALVAAAAFSGWCVHHVLEEVQHVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESLVRSSQHKHDLTEKAVKQGESEINRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTDVQKRSQKEINDVKAKVASLEDSEGYKQDLKALKEVVKEIQTSVKSKEKDMEALRSTIQTMESDVYTEVKELVSLKQEQQRFKEAADSEHHTLQALTEKILRAEESAAHLPEEIRRLEEELGQLKAAALRPEEDGAFRPSEAFETLQKESQGLDSRLQSVEDGVQAARAASARQGESLEALRAQSEEQARRLAELQERVAGLGPDADAEGGLAGTVRGLGEAQLSLAGDVDELKRRVAELPGAVEALQKVQEQVHTLLGREATAVPPQDLLDRLSSLDNLRASVGQVESDLKMLRTAVDSLVAYSVKIETNENNLESAKGLLEDLRNDLDRLFVKVEKIHEKV", "length": 589, "header": "tr|F1ME65-1|F1ME65_BOVIN Isoform 1 of Cytoskeleton associated protein 4 OS=Bos taurus OX=9913 GN=CKAP4 PE=1 SV=1 CANONICAL=F1ME65-1" }, "isoforms": [ { "isoform_ac": "F1ME65-1", "url": "https://www.uniprot.org/uniprotkb/F1ME65/entry", "sequence": { "sequence": "MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQHPPPPAPHPQQQHPPQHPQNQAHGKGGHRGGKSSSSAAAAAASSSASCSRRLGRVLNFLFYLALVAAAAFSGWCVHHVLEEVQHVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESLVRSSQHKHDLTEKAVKQGESEINRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTDVQKRSQKEINDVKAKVASLEDSEGYKQDLKALKEVVKEIQTSVKSKEKDMEALRSTIQTMESDVYTEVKELVSLKQEQQRFKEAADSEHHTLQALTEKILRAEESAAHLPEEIRRLEEELGQLKAAALRPEEDGAFRPSEAFETLQKESQGLDSRLQSVEDGVQAARAASARQGESLEALRAQSEEQARRLAELQERVAGLGPDADAEGGLAGTVRGLGEAQLSLAGDVDELKRRVAELPGAVEALQKVQEQVHTLLGREATAVPPQDLLDRLSSLDNLRASVGQVESDLKMLRTAVDSLVAYSVKIETNENNLESAKGLLEDLRNDLDRLFVKVEKIHEKV", "length": 589, "header": "tr|F1ME65-1|F1ME65_BOVIN Isoform 1 of Cytoskeleton associated protein 4 OS=Bos taurus OX=9913 GN=CKAP4 PE=1 SV=1 CANONICAL=F1ME65-1" }, "locus": { "chromosome": "5", "start_pos": 69638944, "end_pos": 69631581, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015804.5", "url": "https://www.ensembl.org/id/ENSBTAT00000015804.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015804.3", "url": "https://www.ensembl.org/id/ENSBTAP00000015804.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:515784", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515784", "resource": "KEGG Pathway" }, { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-5683826", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5683826", "resource": "Reactome", "description": "Surfactant metabolism" }, { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" }, { "id": "R-BTA-9696264", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696264", "resource": "Reactome", "description": "RND3 GTPase cycle" }, { "id": "R-BTA-9696270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9696270", "resource": "Reactome", "description": "RND2 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZH41-1", "protein_name": "Cytoskeleton-associated protein 4", "gene_name": "Ckap4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSAKQRGSKGGHGAASPSDKGAHPSGGADDVAKKPPPAPQQPQPPAPHPPQHPQNQAHRGGHRGRSSTAAAAASSASCSRRLGRLLNFLFYLSLVAAAAFSGWYVHHVLEEVQQVRRGHQDFSRQRDELGQGLQGVEQKVQSLQAAVGTFESILRSSQHKQDLTEKAVKEGESEINRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTDVQKRSQKEINEVKMKVASLEESKGDRSQDVKVLKEAVKEVQASMKSRERDIEALKSSLQTMESDVYTEVRELVSLKQEQQAFKQAADSERLALQALTEKLLQSEESSSRLPEDIRRLEEELQQLKVGAHGSEEAVVFRDSKAFDELQKQMEGLGARLQYVEDGVYSMQVASASHTESLESLLSKSQEYEQRLAMLQEHVESLGPISDLASTVRSLEETQLALSSDLKGLKQGLGELPGTVESLQEQVHLLLSQDPAQAAGLPPQDFLDRLSSLDNLKSSVSQVESDLKMLRTAVDSLVAYSVKIETNENSLESAKGLLDDLRNDLDRLFVKVEKIHEKI", "length": 575 }, "evidence": [ { "id": "F1ME65", "url": "https://omabrowser.org/oma/group/F1ME65/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SPP8-1", "protein_name": "Cytoskeleton associated protein 4", "gene_name": "CKAP4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQPAPPAPHPQQHPPQHPQNQAHGRGGHRGGKSSSAAAAAAAAAASSSASCSRRLGRALNFLFYLALVAAAAFSGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESIVRSSQHKQDLTEKAVKQGESEINRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDVKAKVASLEDSEGYKQDLKALKEVVKEIQISVKSKEKDIEALRSTVQTMESDVYTEVKELVSLKQEQQRFKEAADSEHLTLQALTEKILRAEESAARLPEEIQLEEELGQLKAAALRPEEDGVFRPSEAFETLQKESQGLDSRLQSVEDGVQAAQEAWARQSESLEALRAQSAEHAQRLAELRERLAGLGPAPDAADGGLAGAVRGLGESQVSLSSDVDELKRRVAELPGAVEALQKVQEQVRTLLDRDAATAAPPQDLLDRLSSLDNLRASVGQVESDLKMLRTAVDSLVAYSVKIETNENNLESAKGLLEDLRNDLDRLFVKVEKIHEKV", "length": 591 }, "evidence": [ { "id": "F1ME65", "url": "https://omabrowser.org/oma/group/F1ME65/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q07065-1", "protein_name": "Cytoskeleton-associated protein 4", "gene_name": "CKAP4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQPPPPPAPHPQQHPQQHPQNQAHGKGGHRGGGGGGGKSSSSSSASAAAAAAAASSSASCSRRLGRALNFLFYLALVAAAAFSGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV", "length": 602 }, "evidence": [ { "id": "F1ME65", "url": "https://omabrowser.org/oma/group/F1ME65/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BMK4-1", "protein_name": "Cytoskeleton-associated protein 4", "gene_name": "Ckap4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPSAKQRGSKGGHGAASPSDKGAHPSGGADDVAKKPPAAPQQPQPPAPHPPQHPQNQAHRGGHRGRSSAATANASSASCSRRLGRVLNFLFYLSLVAAAAFSGWYVHHVLEEVQQVRRGHQDFSRQRDELGQGLQGVEQKVQSLQATFGTFESLLRNSQHKQDLTEKAVKEGESELNRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTDVQKRSQKEINEVKMKVASLEESKGDRSQDVKTLKDAVKEVQASMMSRERDIEALKSSLQTMESDVYTEVRELVSLKQEQQAFKQAADSERLALQALTEKLLRSEESSSRLPEDIRRLEEELQQLKVGAHGSEEGAVFKDSKALEELQRQIEGLGARLQYVEDGVYSMQVASARHTESLESLLSKSQEYEQRLAMLQEHVGNLGSSSDLASTVRSLGETQLALSSDLKELKQSLGELPGTVESLQEQVLSLLSQDQAQAEGLPPQDFLDRLSSLDNLKSSVSQVESDLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFLKVEKIHEKI", "length": 575 }, "evidence": [ { "id": "F1ME65", "url": "https://omabrowser.org/oma/group/F1ME65/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "rough endoplasmic reticulum", "id": "GO:0005791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005791", "evidence": [ { "database": "UniProtKB", "id": "F1ME65", "url": "https://www.uniprot.org/uniprotkb/F1ME65" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "F1ME65", "url": "https://www.uniprot.org/uniprotkb/F1ME65" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1ME65", "url": "https://www.uniprot.org/uniprotkb/F1ME65" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1ME65-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 589, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1ME65-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ME65" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1ME74-1", "uniprot_ac": "F1ME74", "uniprot_id": "F1ME74_BOVIN", "mass": { "chemical_mass": 77142.0, "monoisotopic_mass": 77142.0 }, "refseq": { "ac": "NP_001137347", "name": "adhesion G protein-coupled receptor F4 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137347" }, "gene_names": [ { "name": "ADGRF4", "type": "recommended", "evidence": [ { "id": "F1ME74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME74" } ] }, { "name": "ADGRF4", "type": "synonym", "evidence": [ { "id": "NP_001137347", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137347" } ] }, { "name": "GPR115", "type": "synonym", "evidence": [ { "id": "NP_001137347", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137347" } ] } ], "protein_names": [ { "name": "Adhesion G protein-coupled receptor F4", "type": "synonym", "evidence": [ { "id": "F1ME74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME74/entry#names_and_taxonomy" } ] }, { "name": "G protein-coupled receptor 115", "type": "synonym", "evidence": [ { "id": "NP_001137347", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137347" } ] }, { "name": "adhesion G protein-coupled receptor F4 precursor", "type": "synonym", "evidence": [ { "id": "NP_001137347", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137347" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1ME74", "url": "https://www.uniprot.org/uniprotkb/F1ME74" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADGRF4", "url": "https://www.uniprot.org/uniprotkb/F1ME74", "locus": { "chromosome": "23", "start_pos": 20764804, "end_pos": 20751643, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002934", "url": "https://www.ensembl.org/id/ENSBTAG00000002934" } ] } } ], "crossref": [ { "id": "F1ME74", "url": "https://alphafold.ebi.ac.uk/entry/F1ME74", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002934", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002934", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15994", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15994", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517950", "url": "https://www.ncbi.nlm.nih.gov/gene/517950", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051587", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051587", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057244", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057244", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517950", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517950", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CETTLEI", "url": "https://omabrowser.org/oma/group/CETTLEI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1ME74", "url": "https://www.orthodb.org/?gene=F1ME74", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45813", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45813", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45813:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45813:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01825", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01825", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27521", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27521", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001137347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137347", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1ME74", "url": "https://www.uniprot.org/uniprotkb/F1ME74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME74-1", "url": "https://www.uniprot.org/uniprotkb/F1ME74-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKSQATTICCLILILATEYSQSRFHIRAKDGDKLQGPERKPKTGRTQEKCHGPCSTSSNCSQPCAQHFHGEIGFICNGNKWQKSTETCTSLSVETLFMDSNSASRLSVAAPSITLHILDYQTPEPIRSVAQGIQKNCPLDYACIINAVKSSEATSGNIAFIVELLKNISTDLSDNVTREKMKSYSKVANHILDPAVIPNWAFIPDKNVSSDLLQSVNWFARQLHIQNEPEHIVDEFFIQTKGFPINNNTSERSLRFSMSLNNTVEGILGIIEIPRQELWKLPPDASQAVGIAFPTLGAVLKEAHLENTRLPRLVNGLVLSVILPEKLEQILFTFEKINKSQNARAKCVGWHSRKRRWDENVCETKLDTKNRVQCRCNYTNVMVSFSILMSPISVDNKVLDYITCIGLSVSILSLILCLMIEATVWSRVVMTDISYMRHVCIVNIAVSLLTANVWFILGSNFNKKAQDYNWCVAVTFFSHFFYLCLFFWMLFKALLIIYGLLVVFRRMMKSRMMAIGFAIGYGCPLVIAATTVAITVPGKGYVRRGACWLNWDDTKALLAFAVPALVIVAVNLIVVLVVAINTQRPSIGSSKSQDVAIILRISKNVAILTPLLGLTWGFGIATLIEGTSLIFHIIFALLNAFQGFFILLFGTIMDHKIRDALRMRMSSLKGQSRVAENASLSPTYGSKLMNR", "length": 691, "header": "tr|F1ME74-1|F1ME74_BOVIN Isoform 1 of Adhesion G protein-coupled receptor F4 OS=Bos taurus OX=9913 GN=ADGRF4 PE=3 SV=2 CANONICAL=F1ME74-1" }, "isoforms": [ { "isoform_ac": "F1ME74-1", "url": "https://www.uniprot.org/uniprotkb/F1ME74/entry", "sequence": { "sequence": "MKSQATTICCLILILATEYSQSRFHIRAKDGDKLQGPERKPKTGRTQEKCHGPCSTSSNCSQPCAQHFHGEIGFICNGNKWQKSTETCTSLSVETLFMDSNSASRLSVAAPSITLHILDYQTPEPIRSVAQGIQKNCPLDYACIINAVKSSEATSGNIAFIVELLKNISTDLSDNVTREKMKSYSKVANHILDPAVIPNWAFIPDKNVSSDLLQSVNWFARQLHIQNEPEHIVDEFFIQTKGFPINNNTSERSLRFSMSLNNTVEGILGIIEIPRQELWKLPPDASQAVGIAFPTLGAVLKEAHLENTRLPRLVNGLVLSVILPEKLEQILFTFEKINKSQNARAKCVGWHSRKRRWDENVCETKLDTKNRVQCRCNYTNVMVSFSILMSPISVDNKVLDYITCIGLSVSILSLILCLMIEATVWSRVVMTDISYMRHVCIVNIAVSLLTANVWFILGSNFNKKAQDYNWCVAVTFFSHFFYLCLFFWMLFKALLIIYGLLVVFRRMMKSRMMAIGFAIGYGCPLVIAATTVAITVPGKGYVRRGACWLNWDDTKALLAFAVPALVIVAVNLIVVLVVAINTQRPSIGSSKSQDVAIILRISKNVAILTPLLGLTWGFGIATLIEGTSLIFHIIFALLNAFQGFFILLFGTIMDHKIRDALRMRMSSLKGQSRVAENASLSPTYGSKLMNR", "length": 691, "header": "tr|F1ME74-1|F1ME74_BOVIN Isoform 1 of Adhesion G protein-coupled receptor F4 OS=Bos taurus OX=9913 GN=ADGRF4 PE=3 SV=2 CANONICAL=F1ME74-1" }, "locus": { "chromosome": "23", "start_pos": 20764792, "end_pos": 20752000, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003815.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003815.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003815.4", "url": "https://www.ensembl.org/id/ENSBTAP00000003815.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517950", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517950", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZTY4-1", "protein_name": "Adhesion G protein-coupled receptor F4", "gene_name": "Adgrf4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKPWIAMLCCLVFFLTTECSHSKSKTHRKDEDKFQISLQKHEFRPTQGKCDGPCSSFSSCNQSCAWNFRGEIVFTCNQNKWQKTIETCTSLSVEALFQRTHPATGLSLASSSVFPMNLIGNTAPVHIGNVSEGIRKYCPEDYFCIVDVVKSSAVTSGNIAFVVELLKNISSDLQTYGMHASVTWKKMKNYGKMANHILGPTAISNWAFIPNKNASSDLLDSVNSFAKKLQIHGKSESVVDELFIQTKGSRISHGTSGNSLSLSVPRYNATEDVLVLIEIPRQALQELSSNTSQAIAVAFPTLGAILKEVHQPNSSLQKPINDLILSLVLPEGLNEIILTFDKINKSQSTSSQCVSWDAEERQWDESPCTVMSDINSTVKCRCRHNKAVMSFSILMSSKPVKDMILNRITFIGLSVSIFSLVLCLVIEAIVWSRVVVTEISYMRHVCIVNIAVSLLTANVWFIIGSNFSANAQEDHKWCVAVTFFCHFFFLSLFFWMLFKALLIVYGILVVFRRMMKSRMMAIGFAIGYGCPLVIAVITVSVTEPGEGYTRRDACWLNWNQTKALFAFAIPALAIVAVNLLVVLTVAINTQRPLIGSSKSQDMAIVFRISKNVAILTPLLGLTWGFGLTTLLEGTHLVFHIIFALLNAFQGLFILLFGTIMDHKIRDALRMRVSSLKGKSRAAEKVSLSPANGSRILNR", "length": 698 }, "evidence": [ { "id": "F1ME74", "url": "https://omabrowser.org/oma/group/F1ME74/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8IZF3-1", "protein_name": "Adhesion G protein-coupled receptor F4", "gene_name": "ADGRF4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKMKSQATMICCLVFFLSTECSHYRSKIHLKAGDKLQSPEGKPKTGRIQEKCEGPCISSSNCSQPCAKDFHGEIGFTCNQKKWQKSAETCTSLSVEKLFKDSTGASRLSVAAPSIPLHILDFRAPETIESVAQGIRKNCPFDYACITDMVKSSETTSGNIAFIVELLKNISTDLSDNVTREKMKSYSEVANHILDTAAISNWAFIPNKNASSDLLQSVNLFARQLHIHNNSENIVNELFIQTKGFHINHNTSEKSLNFSMSMNNTTEDILGMVQIPRQELRKLWPNASQAISIAFPTLGAILREAHLQNVSLPRQVNGLVLSVVLPERLQEIILTFEKINKTRNARAQCVGWHSKKRRWDEKACQMMLDIRNEVKCRCNYTSVVMSFSILMSSKSMTDKVLDYITCIGLSVSILSLVLCLIIEATVWSRVVVTEISYMRHVCIVNIAVSLLTANVWFIIGSHFNIKAQDYNMCVAVTFFSHFFYLSLFFWMLFKALLIIYGILVIFRRMMKSRMMVIGFAIGYGCPLIIAVTTVAITEPEKGYMRPEACWLNWDNTKALLAFAIPAFVIVAVNLIVVLVVAVNTQRPSIGSSKSQDVVIIMRISKNVAILTPLLGLTWGFGIATLIEGTSLTFHIIFALLNAFQGFFILLFGTIMDHKIRDALRMRMSSLKGKSRAAENASLGPTNGSKLMNRQG", "length": 695 }, "evidence": [ { "id": "F1ME74", "url": "https://omabrowser.org/oma/group/F1ME74/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D2L6-1", "protein_name": "Adhesion G 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"start_pos": 677, "end_pos": 679, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1ME74-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 691, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1ME74-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ME74" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1ME74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME74" }, { "id": "PS50261", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50261" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 2 profile 2", "eco_id": "ECO_0000259", "start_pos": 399, "end_pos": 654, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1ME74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME74" }, { "id": "PS50221", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50221" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GAIN-B", "eco_id": "ECO_0000259", "start_pos": 244, "end_pos": 395, "start_aa": "Pro", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 167, "end_pos": 169 }, { "start_pos": 175, "end_pos": 177 }, { "start_pos": 207, "end_pos": 209 }, { "start_pos": 247, "end_pos": 249 }, { "start_pos": 248, "end_pos": 250 }, { "start_pos": 261, "end_pos": 263 }, { "start_pos": 338, "end_pos": 340 }, { "start_pos": 377, "end_pos": 379 }, { "start_pos": 59, "end_pos": 61 }, { "start_pos": 677, "end_pos": 679 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1ME76-1", "uniprot_ac": "F1ME76", "uniprot_id": "F1ME76_BOVIN", "mass": { "chemical_mass": 29518.0, "monoisotopic_mass": 29518.0 }, "refseq": {}, "gene_names": [ { "name": "DUSP13B", "type": "recommended", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "name": "DUSP13A", "type": "synonym", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ], "protein_names": [ { "name": "Dual specificity protein phosphatase 13B", "type": "recommended", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.16", "type": "synonym", "evidence": [ { 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Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.", "evidence": [ { "database": "UniProtKB", "id": "F1ME76", "url": "https://www.uniprot.org/uniprotkb/F1ME76#function" }, { "database": "UniProtKB", "id": "ARBA00058283", "url": "https://www.uniprot.org/uniprotkb/ARBA00058283#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1ME76", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DUSP13B", "url": "https://www.uniprot.org/uniprotkb/F1ME76", "locus": { "chromosome": "28", "start_pos": 30868170, "end_pos": 30872593, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023039", "url": "https://www.ensembl.org/id/ENSBTAG00000023039" } ] } } ], "crossref": [ { "id": "F1ME76", "url": "https://alphafold.ebi.ac.uk/entry/F1ME76", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023039", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023039", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016130", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020405", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020405", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MG88", "url": "https://www.orthodb.org/?gene=F1MG88", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45682", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45682", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45682:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45682:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45682:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45682:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00782", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00782", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "10684", "url": "https://www.rhea-db.org/rhea/10684", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "20629", "url": "https://www.rhea-db.org/rhea/20629", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47004", "url": "https://www.rhea-db.org/rhea/47004", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1ME76", "url": "https://www.uniprot.org/uniprotkb/F1ME76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME76-1", "url": "https://www.uniprot.org/uniprotkb/F1ME76-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG88", "url": "https://www.uniprot.org/uniprotkb/F1MG88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG88-1", "url": "https://www.uniprot.org/uniprotkb/F1MG88-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKQHQVCRDRRLKAGSKKCPSEKTTAWAKYPHRVSDSLSQLTPDTSHPTAVRPDLQHWPESQGMDSLQKQDLRRPKIHGSVRVSPYQPPTLASLQRLLWVRRAAMLNHINEVWPNLFLGDAYAARDKKKLTQLGITHVVNVAAGKFQVDTGAKFYRGMPLEYYGIEADDNPFFDLSVYFLPVARYIRSALSVPQGRVLVHCAMGVSRSATVVLAFLMICENMTLVEAIQTVQAHRDICPNSGFLRQLQVLDNRLGRETGRL", "length": 261, "header": "tr|F1ME76-1|F1ME76_BOVIN Isoform 1 of Dual specificity protein phosphatase 13B OS=Bos taurus OX=9913 GN=DUSP13B PE=3 SV=4 CANONICAL=F1ME76-1" }, "isoforms": [ { "isoform_ac": "F1ME76-1", "url": "https://www.uniprot.org/uniprotkb/F1ME76/entry", "sequence": { "sequence": "MKQHQVCRDRRLKAGSKKCPSEKTTAWAKYPHRVSDSLSQLTPDTSHPTAVRPDLQHWPESQGMDSLQKQDLRRPKIHGSVRVSPYQPPTLASLQRLLWVRRAAMLNHINEVWPNLFLGDAYAARDKKKLTQLGITHVVNVAAGKFQVDTGAKFYRGMPLEYYGIEADDNPFFDLSVYFLPVARYIRSALSVPQGRVLVHCAMGVSRSATVVLAFLMICENMTLVEAIQTVQAHRDICPNSGFLRQLQVLDNRLGRETGRL", "length": 261, "header": "tr|F1ME76-1|F1ME76_BOVIN Isoform 1 of Dual specificity protein phosphatase 13B OS=Bos taurus OX=9913 GN=DUSP13B PE=3 SV=4 CANONICAL=F1ME76-1" }, "locus": { "chromosome": "28", "start_pos": 30875495, "end_pos": 30868408, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003801.8", "url": "https://www.ensembl.org/id/ENSBTAT00000003801.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003801.7", "url": "https://www.ensembl.org/id/ENSBTAP00000003801.7" } ] } }, { "isoform_ac": "F1MG88-1", "url": "https://www.uniprot.org/uniprotkb/F1MG88/entry", "sequence": { "sequence": "MAEASLPQLRGDAEATPCPSVLELEELLRAGKVSSSHVDEVWPNLYIGDAATANNRFELWKLGITHVLNAAHGGLYCQGSPDFYGSSVSYLGVPAHDLPEFDISVYFSSAADFIHRALSTPGGPGALRGRGEPLRHTGPGLPHAAPAALPAPGGDHREGAPMGLPQQRFPSPALPAGPAAAGCRPELRGQSWALLPAMGLCHFALALLVLLEVVAHVDTQKMV", "length": 223, "header": "tr|F1MG88-1|F1MG88_BOVIN Computationally mapped isoform of Dual specificity protein phosphatase OS=Bos taurus OX=9913 GN=DUSP13B PE=3 SV=5 CANONICAL=F1ME76-1" }, "locus": { "chromosome": "28", "start_pos": 30881102, "end_pos": 30875980, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031313.7", "url": "https://www.ensembl.org/id/ENSBTAT00000031313.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031268.7", "url": "https://www.ensembl.org/id/ENSBTAP00000031268.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1ME76", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein serine/threonine phosphatase activity", "id": "GO:0004722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", "evidence": [ { "database": "UniProtKB", "id": "F1ME76", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0043409", "evidence": [ { "database": "UniProtKB", "id": "F1ME76", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1ME76-1", "F1MRH9-1", "A0AAF6DLF7-1", "A0AAA9S9Q3-1", "E1BFE2-1", "E1BL76-1", "G3MXS7-1", "A0A3Q1LUB1-1", "A0AAA9THG9-1", "F1N339-1", "F6RY99-1", "A0AAF6YUC8-1", "A0AAA9RTM1-1", "A0AAA9SMJ6-1", "A0A3Q1LZA9-1", "A7MBD1-1", "A5D7P0-1", "Q58DB6-1", "A0AAA9SEK4-1", "E1BDH9-1", "F1MGK4-1", "E1BIH4-1", "A0A3Q1M6K1-1", "E1BIU8-1", "A7MBJ4-1", "A6H730-1", "A0A3Q1MFX2-1", "A0AAA9U0H6-1", "A2VDT1-1", "E1BPU9-1", "P0C591-1", "P11064-1", "Q0IID7-1", "Q2KJ36-1", "Q2T9S4-1", "E1BPA0-1", "A0AAA9TAZ9-1", "Q5BIP9-1", "A0A3Q1M5K4-1", "F1MM08-1", "E1BJR7-1", "Q17QJ3-1", "Q17QM8-1", "F1MD22-1", "F1MI99-1", "F1MP34-1", "F1MGK5-1", "F1MEZ2-1", "F1MQM7-1", "E1BEZ8-1", "A0A3Q1M0B4-1", "A0AAA9S7W5-1", "A0A3Q1N8V6-1", "A0AAA9TFV5-1", "A0A3Q1MBB1-1", "F1MTZ3-1", "A0AAF6Z8C2-1", "F1MDF1-1", "A0AAA9T5N9-1", "E1BKT4-1", "A0A3Q1MH98-1", "F1N6L3-1", "F1MW70-1", "F1MXF2-1", "A0AAA9TWD1-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] }, { "id": "20629", "name": "", "equation": "O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BEW5-1", "A0AAA9TV14-1", "A0AAA9S745-1", "A0A3Q1MV48-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "F1MBQ1-1", "A0AAA9RTM1-1", "A0AAF6YJP2-1", "P48452-1", "F1MI99-1", "G3N3B3-1", "O62830-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "A6H772-1", "O62829-1", "P61287-1", "A0AAA9U0H6-1", "Q3ZBF9-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q0P594-1", "Q1RMV9-1", "Q2KJ36-1", "Q2PC20-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0A3Q1N224-1", "E1BMD4-1", "A0AAF6DLF7-1", "F1N580-1", "F1MQM7-1", "F1MW60-1", "F1N719-1", "E1BF95-1", "E1BIE7-1", "F1MEZ2-1", "F1MM08-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "20629", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20629" } ] }, { "id": "47004", "name": "", "equation": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAF6DLF7-1", "F1MI92-1", "A0A3Q1MV48-1", "E1BEW5-1", "F1ME76-1", "E1BAB2-1", "E1BBD9-1", "A0A3Q1N5B2-1", "A0ABI0P1A3-1", "F1MBQ1-1", "A0AAA9RTM1-1", "G3N3B3-1", "A0AAF6YJP2-1", "P48452-1", "O62829-1", "Q0IIF0-1", "A5PJZ2-1", "Q17QJ3-1", "F6RRD7-1", "Q5BIP9-1", "A0AAA9TT76-1", "Q0P594-1", "A6H772-1", "O62830-1", "P61287-1", "A0AAA9U0H6-1", "Q3SWW9-1", "Q3T0E7-1", "P0C591-1", "P67774-1", "Q0IID7-1", "Q1RMV9-1", "Q2KJ36-1", "P79126-1", "Q17QI2-1", "Q17QM8-1", "Q2KJD7-1", "E1B9Y5-1", "E1BIZ2-1", "F1MI99-1", "F1MP34-1", "F1MEZ2-1", "F1MQM7-1", "F1MM08-1", "F1N719-1", "A0AAA9T455-1", "Q58DC0-1", "A0AAA9SWY4-1", "A0A3Q1LZA9-1", "A0AAA9S454-1", "A0AAA9SCR0-1", "A0AAA9TD32-1", "A0AAA9TV14-1", "A0AAA9S745-1", "F1N580-1", "E1BMD4-1", "E1BF95-1", "E1BIE7-1", "A0A3Q1N224-1", "A0A3Q1MLC5-1", "A0A3Q1MH98-1", "F1MW70-1", "A0A3Q1MZU1-1" ], "evidence": [ { "id": "47004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47004" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUB1", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] } ] }, { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B4", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] } ] }, { "uniprot_ac": "A0A3Q1M5K4", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] } ] }, { "uniprot_ac": "A0A3Q1M6K1", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] } ] }, { "uniprot_ac": "A0A3Q1MBB1", "gene_name": "TNS2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] } ] }, { "uniprot_ac": "A0A3Q1MFX2", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1MLC5", "gene_name": "DUSP8", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MLC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLC5" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MLC5", "database": 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"evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MV48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MV48" } ] } ] }, { "uniprot_ac": "A0A3Q1MZU1", "gene_name": "CTDSPL2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MZU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZU1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MZU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZU1" } ] } ] }, { "uniprot_ac": "A0A3Q1N224", "gene_name": "PHLPP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N224", "database": 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}, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": 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"ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9S745", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S745" } ] } ] }, { "uniprot_ac": "A0AAA9S7W5", "gene_name": "PTPRV", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] } ] }, { "uniprot_ac": "A0AAA9S9Q3", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] } ] }, { "uniprot_ac": "A0AAA9SCR0", "gene_name": "LOC112441582", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCR0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SCR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SCR0" } ] } ] }, { "uniprot_ac": "A0AAA9SEK4", "gene_name": "PTPRE", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] } ] }, { "uniprot_ac": "A0AAA9SMJ6", "gene_name": "PTPRH", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SMJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMJ6" } ] } ] }, { "uniprot_ac": "A0AAA9SWY4", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] } ] }, { "uniprot_ac": "A0AAA9T455", "gene_name": "CDKN3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T455" } ] } ] }, { "uniprot_ac": "A0AAA9T5N9", "gene_name": "", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9T5N9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5N9" } ] } ] }, { "uniprot_ac": "A0AAA9TAZ9", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TAZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAZ9" } ] } ] }, { "uniprot_ac": "A0AAA9TD32", "gene_name": "CTDP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD32" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD32" } ] } ] }, { "uniprot_ac": "A0AAA9TFV5", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] } ] }, { "uniprot_ac": "A0AAA9THG9", "gene_name": "PTPRK", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] } ] }, { "uniprot_ac": "A0AAA9TT76", "gene_name": "PPP3CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TT76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT76" } ] } ] }, { "uniprot_ac": "A0AAA9TV14", "gene_name": "CTDSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9TV14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV14" } ] } ] }, { "uniprot_ac": "A0AAA9TWD1", "gene_name": "PTPN20", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TWD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWD1" } ] } ] }, { "uniprot_ac": "A0AAA9U0H6", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YJP2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6YJP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YJP2" } ] } ] }, { "uniprot_ac": "A0AAF6YUC8", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] } ] }, { "uniprot_ac": "A0AAF6Z8C2", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ] }, { "uniprot_ac": "A0ABI0P1A3", "gene_name": "SSH2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0ABI0P1A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1A3" } ] } ] }, { "uniprot_ac": "A2VDT1", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] } ] }, { "uniprot_ac": "A5D7P0", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] } ] }, { "uniprot_ac": "A5PJZ2", "gene_name": "PPM1L", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A5PJZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJZ2" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A6H772", "gene_name": "PPP4C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A6H772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H772" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "A7MBJ4", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] } ] }, { "uniprot_ac": "E1B9Y5", "gene_name": "PPEF2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1B9Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Y5" } ] } ] }, { "uniprot_ac": "E1BAB2", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAB2" } ] } ] }, { "uniprot_ac": "E1BBD9", "gene_name": "LOC112445820", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BBD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBD9" } ] } ] }, { "uniprot_ac": "E1BDH9", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] } ] }, { "uniprot_ac": "E1BEW5", "gene_name": "PPTC7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BEW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW5" } ] } ] }, { "uniprot_ac": "E1BEZ8", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] } ] }, { "uniprot_ac": "E1BF95", "gene_name": "PPM1F", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BF95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF95" } ] } ] }, { "uniprot_ac": "E1BFE2", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] } ] }, { "uniprot_ac": "E1BIE7", "gene_name": "PGAM5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIE7" } ] } ] }, { "uniprot_ac": "E1BIH4", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] } ] }, { "uniprot_ac": "E1BIU8", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] } ] }, { "uniprot_ac": "E1BIZ2", "gene_name": "SSH1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIZ2" } ] } ] }, { "uniprot_ac": "E1BJR7", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] } ] }, { "uniprot_ac": "E1BKT4", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] } ] }, { "uniprot_ac": "E1BL76", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] } ] }, { "uniprot_ac": "E1BMD4", "gene_name": "PHLPP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E1BMD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMD4" } ] } ] }, { "uniprot_ac": "E1BPA0", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] } ] }, { "uniprot_ac": "E1BPU9", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] } ] }, { "uniprot_ac": "F1MBQ1", "gene_name": "PPEF1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MBQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBQ1" } ] } ] }, { "uniprot_ac": "F1MD22", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] } ] }, { "uniprot_ac": "F1MDF1", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MGK4", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] } ] }, { "uniprot_ac": "F1MGK5", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] } ] }, { "uniprot_ac": "F1MI92", "gene_name": "SSH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI92" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MRH9", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] } ] }, { "uniprot_ac": "F1MTZ3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] } ] }, { "uniprot_ac": "F1MW60", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "F1MW60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW60" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] } ] }, { "uniprot_ac": "F1MXF2", "gene_name": "MDP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXF2" } ] } ] }, { "uniprot_ac": "F1N339", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N339" } ] } ] }, { "uniprot_ac": "F1N580", "gene_name": "PPM1E", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N580" } ] } ] }, { "uniprot_ac": "F1N6L3", "gene_name": "PTPN22", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1N6L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6L3" } ] } ] }, { "uniprot_ac": "F1N719", "gene_name": "PPP5C", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1N719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N719" } ] } ] }, { "uniprot_ac": "F6RRD7", "gene_name": "RPAP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F6RRD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RRD7" } ] } ] }, { "uniprot_ac": "F6RY99", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F6RY99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RY99" } ] } ] }, { "uniprot_ac": "G3MXS7", "gene_name": "PTPRG", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3MXS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MXS7" } ] } ] }, { "uniprot_ac": "G3N3B3", "gene_name": "PPM1N", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "G3N3B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N3B3" } ] } ] }, { "uniprot_ac": "O62829", "gene_name": "PPM1A", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62829" } ] } ] }, { "uniprot_ac": "O62830", "gene_name": "PPM1B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O62830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O62830" } ] } ] }, { "uniprot_ac": "P0C591", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P0C591" } ] } ] }, { "uniprot_ac": "P11064", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P11064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P11064" } ] } ] }, { "uniprot_ac": "P48452", "gene_name": "PPP3CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48452" } ] } ] }, { "uniprot_ac": "P61287", "gene_name": "PPP1CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P61287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61287" } ] } ] }, { "uniprot_ac": "P67774", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67774", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67774" } ] } ] }, { "uniprot_ac": "P79126", "gene_name": "PPM1G", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P79126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79126" } ] } ] }, { "uniprot_ac": "Q0IID7", "gene_name": "DUSP10", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q0IID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IID7" } ] } ] }, { "uniprot_ac": "Q0IIF0", "gene_name": "ILKAP", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0IIF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIF0" } ] } ] }, { "uniprot_ac": "Q0P594", "gene_name": "PPP2CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q0P594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P594" } ] } ] }, { "uniprot_ac": "Q17QI2", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QI2" } ] } ] }, { "uniprot_ac": "Q17QJ3", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QJ3" } ] } ] }, { "uniprot_ac": "Q17QM8", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q17QM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QM8" } ] } ] }, { "uniprot_ac": "Q1RMV9", "gene_name": "CTDNEP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMV9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q1RMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMV9" } ] } ] }, { "uniprot_ac": "Q2KJ36", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ36" } ] } ] }, { "uniprot_ac": "Q2KJD7", "gene_name": "UBLCP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2KJD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJD7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2KJD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJD7" } ] } ] }, { "uniprot_ac": "Q2PC20", "gene_name": "PPM1K", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.52", "activity": "O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + H2O = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate.", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.52", "activity": "", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q2PC20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PC20" } ] } ] }, { "uniprot_ac": "Q2T9S4", "gene_name": "PGP", 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"3.1.3.16", "activity": "", "evidence": [ { "id": "Q3T0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0E7" } ] } ] }, { "uniprot_ac": "Q3ZBF9", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q3ZBF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBF9" } ] } ] }, { "uniprot_ac": "Q58DB6", 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"https://data.glygen.org/ln2downloads/pdb/current/AF-F1ME76-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ME76" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" }, { "id": "PS50056", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50056" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine specific protein phosphatases", "eco_id": "ECO_0000259", "start_pos": 177, "end_pos": 235, "start_aa": "Val", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" }, { "id": "PS50054", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50054" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Tyrosine-protein phosphatase", "eco_id": "ECO_0000259", "start_pos": 108, "end_pos": 256, "start_aa": "His", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.16", "ec_name": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "3.1.3.16", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16" }, { "id": "3.1.3.16", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.16" } ] }, { "ec_number": "3.1.3.48", "ec_name": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "3.1.3.48", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48" }, { "id": "3.1.3.48", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.48" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 221, "end_pos": 223 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1ME81-1", "uniprot_ac": "F1ME81", "uniprot_id": "F1ME81_BOVIN", "mass": { "chemical_mass": 26283.0, "monoisotopic_mass": 26283.0 }, "refseq": {}, "gene_names": [ { "name": "LOC615640", "type": "recommended", "evidence": [ { "id": "F1ME81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME81" } ] } ], "protein_names": [ { "name": "G-protein coupled receptors family 1 profile domain-containing protein", "type": "recommended", "evidence": [ { "id": "F1ME81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME81/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { 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Classification" ] }, { "id": "CLQLTVC", "url": "https://omabrowser.org/oma/group/CLQLTVC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24237", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24237", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24237:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24237:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1ME81", "url": "https://www.uniprot.org/uniprotkb/F1ME81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME81-1", "url": "https://www.uniprot.org/uniprotkb/F1ME81-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSTADPSSLVHHTNSCLPHHPPRVASVMLSLFYTALLIFAVLGNILALRLAYQKDKKINSTGVFLVHLSVSDLLFVLTLPGKITYFLLDFNWPFGEGLCRLTAFIFFVNTYSGIYLMTCVSVDRYLAVVRAQQGPRLREPGRAQLICAAVWVLATLQRAFKLCLQLTVCLMNLNCSIDPIVYFFASSRYRKWLRHFLKLKASPSSPSFPQGKASSETQSINQTGGSSPLEENEV", "length": 236, "header": "tr|F1ME81-1|F1ME81_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC615640 PE=3 SV=1 CANONICAL=F1ME81-1" }, "isoforms": [ { "isoform_ac": "F1ME81-1", "url": "https://www.uniprot.org/uniprotkb/F1ME81/entry", "sequence": { "sequence": "MASSTADPSSLVHHTNSCLPHHPPRVASVMLSLFYTALLIFAVLGNILALRLAYQKDKKINSTGVFLVHLSVSDLLFVLTLPGKITYFLLDFNWPFGEGLCRLTAFIFFVNTYSGIYLMTCVSVDRYLAVVRAQQGPRLREPGRAQLICAAVWVLATLQRAFKLCLQLTVCLMNLNCSIDPIVYFFASSRYRKWLRHFLKLKASPSSPSFPQGKASSETQSINQTGGSSPLEENEV", "length": 236, "header": "tr|F1ME81-1|F1ME81_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC615640 PE=3 SV=1 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"database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1ME83", "url": "https://www.orthodb.org/?gene=F1ME83", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18839", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18839", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18839:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18839:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15304", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15304", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005209316", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209316", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1ME83", "url": "https://www.uniprot.org/uniprotkb/F1ME83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ME83-1", "url": "https://www.uniprot.org/uniprotkb/F1ME83-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDRVTRYPIFGIPHSSRMAGVAFDGDTSYTFELVGVGPTASFWSQDETPAWPTDHEASLEMTRTGTSRSLRVFPGRMAPWPPCPQDNEDEEVKAYHLEARDTPPWQPQNLERERQAVIRGQAVRKGGTVATLRGASDHREPRGPSRPQSMPLEENEIDREQIDFLAVRQQFLNLEQANPPPGAAHANARVLQSPQSKVAHAKTGVSRNAPLGVAHVNSEVPQSPQPKVAHVNAVASQNSPPRASQASKALSRPPLANGYVLPVKPQVKEVVTEEKRVHPLPTRSVAQALEDPGSRSREESPEPLKETPIEREIRLAQEREADLREQRGLQRATSHQELVEIPARLLLSKVSLAAAPRRDRGRPSLYVQRDIAQESQREEDHRREGLQVGRASTPDWSSEGPQPRLRRVHSSDSILSPTPDAHAASLAPEVRKVSRIPPDAYQPYLSPGTPPGESPASHAYCRPSNLSADEARPVGSPKAAGSQRHPSESSAKPSGLKQEPPRGPLHASRGVLRQEYFHLRPLRFRVPDEPERAEAPRVWGWEVAGAPALRLQKSQSSELLEREVENVLRREREMAEERRSALYPEVFSDECCDHDSRSSSRKSSITGSYSVSESHYFTPIHLHSDLVWTVEAPAKDALQQKKKKEQWYAGINPLDDVNSEILEATRVTRHRNAMAERWEAGIYASEDED", "length": 689, "header": "tr|F1ME83-1|F1ME83_BOVIN Isoform 1 of Mitotic spindle positioning OS=Bos taurus OX=9913 GN=MISP PE=4 SV=1 CANONICAL=F1ME83-1" }, "isoforms": [ { "isoform_ac": "F1ME83-1", "url": "https://www.uniprot.org/uniprotkb/F1ME83/entry", "sequence": { "sequence": "MDRVTRYPIFGIPHSSRMAGVAFDGDTSYTFELVGVGPTASFWSQDETPAWPTDHEASLEMTRTGTSRSLRVFPGRMAPWPPCPQDNEDEEVKAYHLEARDTPPWQPQNLERERQAVIRGQAVRKGGTVATLRGASDHREPRGPSRPQSMPLEENEIDREQIDFLAVRQQFLNLEQANPPPGAAHANARVLQSPQSKVAHAKTGVSRNAPLGVAHVNSEVPQSPQPKVAHVNAVASQNSPPRASQASKALSRPPLANGYVLPVKPQVKEVVTEEKRVHPLPTRSVAQALEDPGSRSREESPEPLKETPIEREIRLAQEREADLREQRGLQRATSHQELVEIPARLLLSKVSLAAAPRRDRGRPSLYVQRDIAQESQREEDHRREGLQVGRASTPDWSSEGPQPRLRRVHSSDSILSPTPDAHAASLAPEVRKVSRIPPDAYQPYLSPGTPPGESPASHAYCRPSNLSADEARPVGSPKAAGSQRHPSESSAKPSGLKQEPPRGPLHASRGVLRQEYFHLRPLRFRVPDEPERAEAPRVWGWEVAGAPALRLQKSQSSELLEREVENVLRREREMAEERRSALYPEVFSDECCDHDSRSSSRKSSITGSYSVSESHYFTPIHLHSDLVWTVEAPAKDALQQKKKKEQWYAGINPLDDVNSEILEATRVTRHRNAMAERWEAGIYASEDED", "length": 689, "header": "tr|F1ME83-1|F1ME83_BOVIN Isoform 1 of Mitotic spindle positioning OS=Bos taurus OX=9913 GN=MISP PE=4 SV=1 CANONICAL=F1ME83-1" }, "locus": { "chromosome": "7", "start_pos": 43334982, "end_pos": 43329881, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000050202.2", "url": "https://www.ensembl.org/id/ENSBTAT00000050202.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046941.1", "url": "https://www.ensembl.org/id/ENSBTAP00000046941.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 39, "start_aa": "Thr", "end_pos": 39, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr39", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287ALE7-1", "protein_name": "Mitotic spindle positioning", "gene_name": "MISP", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDRVTRYPIFSIPHSPRVAGVAFDDGDTSYTFELVGVASGWGQDKPQAWPADHEASLEMAWTERSHGPQAFTAQPPPWPEDDEDEEVKACHLEAQHVPPRRPWDLEQERRLVIQDQAVRRSDTVATLHFHGEPRTPNLLPSTALEENGIDREQIDFLAVRQQFLSLEQANPPPGVAHVNVGAPRNTPPGASQGNAGAPRNPPPGVTQASKAWKGLPLANGYVVPVKPQAKEVVMEEKRVHSLPTRSGVPAVDDRGSQARDRSPEPPKETPIEREIRLAQEREADLRAQRGLQQAAGHQELVEIPARPLLNRVNLAVGPWRDRGRPSLYMQRDIAQESQREEDHRREGLQVGRASTPDGFSEGPQPPLRRAHSSDSILGPAPDARAASPTPEVRKVNRIPPDAYQPYLSPQKPAGELPVFCTYGKPSGLSAGETRAVGSPKATQSPRHPSESSGTKQEPPRQPLPTSGSVVRWKYFRLRPLRFRVPSEPEKAEAPRVWGWEVAGAPALRLQKSQSSELLEREVESVLRREREVAEERRSALYPEVFSPTPDEYCDQDSRSSSGPSGITGSYSVSESHFFTPIHLHPGQTWTAEAPAEAAPWQRRKKEQWYAGIKPLDHVNLEILEATRVTRHKNAMAERWEAGIYASEDED", "length": 650 }, "evidence": [ { "id": "F1ME83", "url": "https://omabrowser.org/oma/group/F1ME83/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6GB45-1", "protein_name": "Mitotic spindle positioning", "gene_name": "Misp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDRVTRYPIFSKPHSARVTGLALDEDTSYTVELVGVGPEAGWSQGDLQTWSAEDQTKPDVKRVSVSSTRRAFLGQQSPRSLYWEDEDEETKAYRVDAGSNAFCRQPRDLEAERWAVIQSQAVRKGGTVATLQASSDHRDPRIASHPRSSFTEEILVDTEQIDFLAARQQFLSLEKANTNPVTWSPTARETFARTPPGVDQTPKASTGPHVANGYTTSVTSPMKEMTLEKTFHFHTSPAGSIRTTDDPGHQTRAESPETPKETPIEREIRLAQEREAELREQRGLGRAAGHQELIQIPSRPLLNKMSLTETPPRRDRGRPSLYVQRDMVQETQREEDHRREGLQVGRASTPDWTSQDPQPGFQRSLSSDCILSPDARAADPAPEARKVNRIPPDAYQPYLGPGTPKLEFSAFGVYSKPSGVHSTEDTKATAFRNTTESPRHVSESSRRSLSSKQEWSKPPGKPANGGVVKLENFHLRPLRFKVPDVPQEAETPQTWGWEVAGGPVLRLQKSQSSDLLEREVESVLRREREVAEERRNAFFPEVFSPVLDQEESHEQDSRSSSRASGITGSYSVSESPLFTPIHLHSGLVWKVEAPEDSSPPGQKTRKESWYAGINPSDGVNSEQITGPTRIRMVCAFEIQAPPKDLCFVACTRLWRTYLHLRPPGLEGRILAPGVKVQEGDSWVYL", "length": 685 }, "evidence": [ { "id": "F1ME83", "url": "https://omabrowser.org/oma/group/F1ME83/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HF45-1", "protein_name": "Mitotic interactor and substrate of PLK1", "gene_name": "Misp", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDRVTRYPIFSNHHAARVTSLVLDDNSSYTVRLVGVGPEVGWSQDDQQAWSTEYQTKPDVKRTSVSSTRRVFLNQPSPRSLYSEDEDEEMKAYHLDTSDALYSQPRDLEAERWAVIHNQAIRKGGTVATLQGEPRPAGQPRSTSTEEILVDTEQIDFLAARQQFLSLEKVNTNPVTWSPTARESFVHTPLGVSQAPKASTRPHLANGYAAPVMSPVKELTLQKKTAHVSPAGSIRAANDPGHWTRAESPETSKETPIEREIRLAQEREAELREQRGLGRVAGHQELVQIPSRPLLNKVSLTELPSRRERGRPSLYVQRDMVQETQREEDHRREGLQVGRAATPDWTSQDPQPGLQRSLSSDCILSPDARATDPAPETRKVNRIPPDAYQPYLGPGTPKLEFSAFGVYSKPNGVSTEDTKAMEFQKAAGSPRHVSEYSGSSPSSKQARSKPPEKPQHGSVGIVQLENFHLRPLRFSVPDVPQQAETSHTWGWEEAGGPVLKLHRSQSSDLLEREMENVLRREREVAEERRNAFFPEVFSPVQDQDEQDSRSSSRASGITGSYSVSESPLFTPIQLHSGLVWKVQAPNDGASGQRTKRETRYAGIKPSDRVNSEVLGATRVTRHRNILAERWEAGIYANEDED", "length": 641 }, "evidence": [ { "id": "F1ME83", "url": "https://omabrowser.org/oma/group/F1ME83/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8IVT2-1", "protein_name": "Mitotic interactor and substrate of PLK1", "gene_name": "MISP", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDRVTRYPILGIPQAHRGTGLVLDGDTSYTYHLVCMGPEASGWGQDEPQTWPTDHRAQQGVQRQGVSYSVHAYTGQPSPRGLHSENREDEGWQVYRLGARDAHQGRPTWALRPEDGEDKEMKTYRLDAGDADPRRLCDLERERWAVIQGQAVRKSSTVATLQGTPDHGDPRTPGPPRSTPLEENVVDREQIDFLAARQQFLSLEQANKGAPHSSPARGTPAGTTPGASQAPKAFNKPHLANGHVVPIKPQVKGVVREENKVRAVPTWASVQVVDDPGSLASVESPGTPKETPIEREIRLAQEREADLREQRGLRQATDHQELVEIPTRPLLTKLSLITAPRRERGRPSLYVQRDIVQETQREEDHRREGLHVGRASTPDWVSEGPQPGLRRALSSDSILSPAPDARAADPAPEVRKVNRIPPDAYQPYLSPGTPQLEFSAFGAFGKPSSLSTAEAKAATSPKATMSPRHLSESSGKPLSTKQEASKPPRGCPQANRGVVRWEYFRLRPLRFRAPDEPQQAQVPHVWGWEVAGAPALRLQKSQSSDLLERERESVLRREQEVAEERRNALFPEVFSPTPDENSDQNSRSSSQASGITGSYSVSESPFFSPIHLHSNVAWTVEDPVDSAPPGQRKKEQWYAGINPSDGINSEVLEAIRVTRHKNAMAERWESRIYASEEDD", "length": 679 }, "evidence": [ { "id": "F1ME83", "url": "https://omabrowser.org/oma/group/F1ME83/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D279-1", "protein_name": "Mitotic interactor and substrate of PLK1", "gene_name": "Misp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDRVTRYPIFSNPRSARVTSLVLDEDTSYTVELVGVGPEAGWSQGDLQAWSTEYQTRPDVKRTNVSSNRRVFLGQQSPRSLYLEDEDEEIKSYHLDDSSDTLCRQRRELEAERWAVIQSQAVRKGGTVATLQAASDHGDLRIARQPQSTVTEEILVDTEQIDFLAARQQFLSLEKANTNPVPCGLTARETFPRTPPGINQAPKASTGPHLANGYTTAVTSPMKEVTLEKSFHVSPARSIHIVNDPGSQTQAESPETPKETPIEREIRLAQEREAELREQRGLGRAAGHQELVQIPSRPLLSKMSLTETPPRRDRGRPSLYVQRDMVQETQREEDHRREGLQVGRASTPDWPSQDPQPGLQRSLSSDCILSPDARATDPAPEARKVNRIPLDAYQPYLGPGTPKLEFSAFGVYSKPSGVSTEDTKATVFQKATESPRHVSESSGRSLSSKQEWSKPPGKATNVGVVRLGNFHLRPLRFKVPDVPQGTETPHTWGWEVAGGPILRLQKSQSSDLLEREMESVLRREREVAEERRNAFFPEVFSPVPAEDESHEQDSRSSSRASGITGSYSVSESPLFTPVHLNSGLVWKVEAPEDSAPPGQKTRKEMWYAGINPSDSVNSEVLGATRVKRHKNLLAERWEAHIYASEDEN", "length": 648 }, "evidence": [ { "id": "F1ME83", "url": "https://omabrowser.org/oma/group/F1ME83/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "actin filament", "id": "GO:0005884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884", "evidence": [ { "database": "UniProtKB", "id": "F1ME83", "url": "https://www.uniprot.org/uniprotkb/F1ME83" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1ME83", "url": "https://www.uniprot.org/uniprotkb/F1ME83" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "F1ME83", "url": "https://www.uniprot.org/uniprotkb/F1ME83" } ], "pmid": "" }, { "name": "cortical actin cytoskeleton", "id": "GO:0030864", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030864", "evidence": [ { "database": "UniProtKB", "id": "F1ME83", "url": "https://www.uniprot.org/uniprotkb/F1ME83" } ], "pmid": "" }, { "name": "spindle pole centrosome", "id": "GO:0031616", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031616", "evidence": [ { "database": "UniProtKB", "id": "F1ME83", "url": "https://www.uniprot.org/uniprotkb/F1ME83" } ], "pmid": "" }, { "name": "mitotic spindle astral microtubule end", "id": "GO:1905721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905721", "evidence": [ { "database": "UniProtKB", "id": "F1ME83", "url": "https://www.uniprot.org/uniprotkb/F1ME83" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "F1ME83", "url": "https://www.uniprot.org/uniprotkb/F1ME83" } ], "pmid": "" }, { "name": "mitotic spindle assembly", "id": "GO:0090307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090307", "evidence": [ { "database": "UniProtKB", "id": "F1ME83", "url": "https://www.uniprot.org/uniprotkb/F1ME83" } ], "pmid": "" }, { "name": "cortical actin cytoskeleton organization", "id": "GO:0030866", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030866", "evidence": [ { "database": "UniProtKB", "id": "F1ME83", "url": "https://www.uniprot.org/uniprotkb/F1ME83" } ], "pmid": "" }, { "name": "establishment of mitotic spindle orientation", "id": "GO:0000132", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000132", "evidence": [ { "database": "UniProtKB", "id": "F1ME83", "url": "https://www.uniprot.org/uniprotkb/F1ME83" } ], "pmid": "" }, { "name": "astral microtubule organization", "id": "GO:0030953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030953", "evidence": [ { "database": "UniProtKB", "id": "F1ME83", "url": "https://www.uniprot.org/uniprotkb/F1ME83" } ], "pmid": "" }, { "name": "establishment of centrosome localization", "id": "GO:0051660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051660", "evidence": [ { "database": "UniProtKB", "id": "F1ME83", "url": "https://www.uniprot.org/uniprotkb/F1ME83" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "F1ME83", "url": "https://www.uniprot.org/uniprotkb/F1ME83" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 465, "end_pos": 467, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1ME83-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 689, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1ME83-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ME83" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 39 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 465, "end_pos": 467 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", 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"https://www.ensembl.org/id/ENSBTAG00000018179" } ] } } ], "crossref": [ { "id": "F1MEC8", "url": "https://alphafold.ebi.ac.uk/entry/F1MEC8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018179", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018179", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513346", "url": "https://www.ncbi.nlm.nih.gov/gene/513346", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513346", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513346", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SCHFEGQ", "url": "https://omabrowser.org/oma/group/SCHFEGQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MEC8", "url": "https://www.orthodb.org/?gene=F1MEC8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179277", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MEC8", "url": "https://www.uniprot.org/uniprotkb/F1MEC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEC8-1", "url": "https://www.uniprot.org/uniprotkb/F1MEC8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPARRGGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLIRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVSVRDINDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQSVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQATYSLGLVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRLRDVNDNAPDISITPLAAPGAPAASPFPAAAAALGGAEATSSTGPGTPEAGAVSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERISEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDPDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPILVHPAPANGSLEVAVPGRTAKDTAVARVQARDADEGANGELAFDLLQQEPREAFAIGRRTGEIVLTGDLSQEPPGRVFRALLVISDGGRPPLSTTATVSFVVTAGGGRGLASPAGAGNPERSRPPGSRLATSGPALQWDTPLIIIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGPRREERPGAAGGVASAPGSPEEAARGAGPRPNMFDVLTFPGSGKAPFGSPAADAPPPAVAAAAEVPGSEGGGATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCAGGPSTHASTHPPAQMSTFCKSTSLPRDPLRRDSYYQAQLPKTVGLQSVYEKVLHRDYDRTATLLSPPRPGRLPDLQEIGVPLYPSPPGRYLSPKKEANENV", "length": 1070, "header": "tr|F1MEC8-1|F1MEC8_BOVIN Isoform 1 of Protocadherin-8 OS=Bos taurus OX=9913 GN=PCDH8 PE=4 SV=2 CANONICAL=F1MEC8-1" }, "isoforms": [ { "isoform_ac": "F1MEC8-1", "url": "https://www.uniprot.org/uniprotkb/F1MEC8/entry", "sequence": { "sequence": "MSPARRGGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLIRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVSVRDINDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQSVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQATYSLGLVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRLRDVNDNAPDISITPLAAPGAPAASPFPAAAAALGGAEATSSTGPGTPEAGAVSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERISEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDPDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPILVHPAPANGSLEVAVPGRTAKDTAVARVQARDADEGANGELAFDLLQQEPREAFAIGRRTGEIVLTGDLSQEPPGRVFRALLVISDGGRPPLSTTATVSFVVTAGGGRGLASPAGAGNPERSRPPGSRLATSGPALQWDTPLIIIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGPRREERPGAAGGVASAPGSPEEAARGAGPRPNMFDVLTFPGSGKAPFGSPAADAPPPAVAAAAEVPGSEGGGATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCAGGPSTHASTHPPAQMSTFCKSTSLPRDPLRRDSYYQAQLPKTVGLQSVYEKVLHRDYDRTATLLSPPRPGRLPDLQEIGVPLYPSPPGRYLSPKKEANENV", "length": 1070, "header": "tr|F1MEC8-1|F1MEC8_BOVIN Isoform 1 of Protocadherin-8 OS=Bos taurus OX=9913 GN=PCDH8 PE=4 SV=2 CANONICAL=F1MEC8-1" }, "locus": { "chromosome": "12", "start_pos": 10913735, "end_pos": 10909872, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024190.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024190.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024190.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024190.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513346", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513346", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZE55-1", "protein_name": "Protocadherin-8", "gene_name": "Pcdh8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSPVKRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQSPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSESAPVGTRIPLEVPVDEDVGANGLQSVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQASYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFTFGARTPPEARHLFRLDPRSGRLTLAGQVDYERQDTYELDVRAQDRGPGPRTATCKVIVRIRDVNDNAPDISITPLAAPGAPATSPFAAAAAAAALGGADAASSAGSGTQETGVTSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTKPVYEVSVRENNPPGAYLATVAARDPDLGRNGQVTYRLVEAEVGRSGEAVSTYVSVDPATGAIYALRSFDYETLRQLDVRVQASDGGSPQLSSNALVQVRVLDQNDHSPVLVHPAPANGSLEVAVPGRSTKDTAVARIQARDADEGANGELAFDLLQQEPREAFSIGRHTGEIVLTGDLSQEPPGRVFKALLVISDGGRPPLTTTATVSFVVTAGGGSAVPASAGSPEHFRPPGSRLAPSGPSLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPGSPDETARGTGPRPNMFDVLTFPGSGKAPFGSPAADAPPPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYSASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCAGPNTHPPPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYESPPGGRYVSPKKGTNENV", "length": 1069 }, "evidence": [ { "id": "F1MEC8", "url": "https://omabrowser.org/oma/group/F1MEC8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RJ67-1", "protein_name": "Protocadherin-8", "gene_name": "PCDH8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSPARRGGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLIRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQSVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPAASPFAAAAAAAALGGADATSSTGPGTPEAGAVSQVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVSDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDPDLGRNGQVTYRLLEAEVGRAGDAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPILVHPAPANGSLEVAVPGRTARDTTVARVQARDADEGANGELAFDLLQQEPREAFAIGRRTGEIVLTGDLSQEPPGRVFRALLVISDGGRPPLSTTATVNFVVTAGGGRGLVSPASGGNPERSRPPGSRLAASGPALQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGPRREELPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGSGKAPFGSPAADAPPPAVAAAEVPGSEGGSATGESSCHLEGQQRLRGPHAEPYGASPGFGKEPAPPVAVWKGHSFNTISGREGEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCGGGPSAHASSHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKEANDNV", "length": 1071 }, "evidence": [ { "id": "F1MEC8", "url": "https://omabrowser.org/oma/group/F1MEC8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O95206-1", "protein_name": "Protocadherin-8", "gene_name": "PCDH8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAPPPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV", "length": 1070 }, "evidence": [ { "id": "F1MEC8", "url": "https://omabrowser.org/oma/group/F1MEC8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TSK3-1", "protein_name": "Protocadherin-8", "gene_name": "Pcdh8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSPAKRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGPSPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSESAPVGTRIPLEVPVDEDVGANGLQSVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQASYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFTFGARTPPEARHLFRLDPRSGRLTLAGQVDYERQDTYELDVRAQDRGPGPRTATCKVIVRIRDVNDNAPEISITPLAAPGAPATSPFAAAAAAAALGGADAASSTGSGTQEAGITSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGTPPLRTVRPYTVRVGDENDNAPIFTKPVYEVSVRENNPPGAYLATVAARDPDVGRNGQVTYRLVEAEVGRSGEAVSTYVSVDPATGAIYALRSFDYETLRQLDVRVQASDGGSPQLSSNALVQVRVLDQNDHSPILVHPAPANGSLEVAVPGRSTKDTAVARIQARDADEGANGELAFDLLQQEPREAFSIGRHTGEIMLTGDLSQEPPGRVFKALLVISDGGRPPLTTTATVSFVVTAGGGSAVPASSGSPEHSRPPGSRLAPSGPSLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPGSPDETARGTGPRPNMFDVLTFPGSGKAPFGSPAADAPPPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCAGPNVHPPPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYESPPGSRYVSPKKGINENV", "length": 1070 }, "evidence": [ { "id": "F1MEC8", "url": "https://omabrowser.org/oma/group/F1MEC8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MEC8", "url": "https://www.uniprot.org/uniprotkb/F1MEC8" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "F1MEC8", "url": "https://www.uniprot.org/uniprotkb/F1MEC8" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1MEC8", "url": "https://www.uniprot.org/uniprotkb/F1MEC8" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "F1MEC8", "url": "https://www.uniprot.org/uniprotkb/F1MEC8" } ], "pmid": "" }, { "name": "presynaptic membrane", "id": "GO:0042734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734", "evidence": [ { "database": "UniProtKB", "id": "F1MEC8", "url": "https://www.uniprot.org/uniprotkb/F1MEC8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MEC8", "url": "https://www.uniprot.org/uniprotkb/F1MEC8" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "F1MEC8", "url": "https://www.uniprot.org/uniprotkb/F1MEC8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "F1MEC8", "url": "https://www.uniprot.org/uniprotkb/F1MEC8" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "F1MEC8", "url": "https://www.uniprot.org/uniprotkb/F1MEC8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 462, "end_pos": 464, "annotation": "n_glycosylation_sequon" }, { "start_pos": 614, "end_pos": 616, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" }, { "start_pos": 924, "end_pos": 926, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MEC8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1070, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MEC8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MEC8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MEC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEC8" }, { "id": "PS50268", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cadherin", "eco_id": "ECO_0000259", "start_pos": 28, "end_pos": 135, "start_aa": "Gln", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], 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"database": "Ensembl Gene", "id": "ENSBTAG00000039149", "url": "https://www.ensembl.org/id/ENSBTAG00000039149" } ] } } ], "crossref": [ { "id": "F1MEE5", "url": "https://alphafold.ebi.ac.uk/entry/F1MEE5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039149", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039149", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "522679", "url": "https://www.ncbi.nlm.nih.gov/gene/522679", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522679", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522679", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": 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"MSWSFHGKIQLGGLLLSLLGCICLCVTTILPRWKTLSLELNEMETWTMGLWEVCVDQEEVATVCKAFESFLSLPQELQASRILMVASHGLGLMGLLLSGFGAECFQFHRIRRVLKRRLCLLGGTLEASAAATTLLPVSWVAYATIQDFWDDSIPEIVPRWEFGDALYLGWASGVFLALGGLLLVFSACLGKEDVTFPHMAVPTTAPPSCAPAEVSDGSFYLMPRPRTLLI", "length": 230, "header": "tr|F1MEE5-1|F1MEE5_BOVIN Isoform 1 of Claudin 25 OS=Bos taurus OX=9913 GN=CLDN25 PE=3 SV=3 CANONICAL=F1MEE5-1" }, "isoforms": [ { "isoform_ac": "F1MEE5-1", "url": "https://www.uniprot.org/uniprotkb/F1MEE5/entry", "sequence": { "sequence": "MSWSFHGKIQLGGLLLSLLGCICLCVTTILPRWKTLSLELNEMETWTMGLWEVCVDQEEVATVCKAFESFLSLPQELQASRILMVASHGLGLMGLLLSGFGAECFQFHRIRRVLKRRLCLLGGTLEASAAATTLLPVSWVAYATIQDFWDDSIPEIVPRWEFGDALYLGWASGVFLALGGLLLVFSACLGKEDVTFPHMAVPTTAPPSCAPAEVSDGSFYLMPRPRTLLI", "length": 230, "header": "tr|F1MEE5-1|F1MEE5_BOVIN Isoform 1 of Claudin 25 OS=Bos taurus OX=9913 GN=CLDN25 PE=3 SV=3 CANONICAL=F1MEE5-1" }, "locus": { "chromosome": "15", "start_pos": 24328854, "end_pos": 24328165, "strand": "-", "evidence": [ { "database": "Ensembl 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"database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "C9JDP6-1", "protein_name": "Claudin-25", "gene_name": "CLDN25", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAWSFRAKVQLGGLLLSLLGWVCSCVTTILPQWKTLNLELNEMETWIMGIWEVCVDREEVATVCKAFESFLSLPQELQVARILMVASHGLGLLGLLLCSFGSECFQFHRIRWVFKRRLGLLGRTLEASASATTLLPVSWVAHATIQDFWDDSIPDIIPRWEFGGALYLGWAAGIFLALGGLLLIFSACLGKEDVPFPLMAGPTVPLSCAPVEESDGSFHLMLRPRNLVI", "length": 229 }, "evidence": [ { "id": "F1MEE5", "url": "https://omabrowser.org/oma/group/F1MEE5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MEE5", "url": "https://www.uniprot.org/uniprotkb/F1MEE5" } ], "pmid": "" }, { "name": "bicellular tight junction", 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"https://www.ebi.ac.uk/interpro/entry/IPR051739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100336895", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336895", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR45840", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45840", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45840:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45840:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01694", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01694", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024841162", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841162", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MEJ0", "url": "https://www.uniprot.org/uniprotkb/F1MEJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEJ0-1", "url": "https://www.uniprot.org/uniprotkb/F1MEJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGTGSRAPFLPGHVLVRGARVSRPRVAGRAVAAACAAGAGGSVTRRRAERAEPEGRGGAESSAEQPLPAAAADPGPGPRPGSMDRSSLLQLIQEQQLDPENTGFIGADTFTGLVHRHELPLDPAKLDMLVALAQSNERGQVCYQELADLISSKRSSSFKRAIANGQRALPRDGLLDEPGLGVYKRFVRYVAYEILPREVDRHWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPEYMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLAGSLTVSITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVLALVCMSSEVGRAVWLRFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWVVLLAYGTFLLFAIFWNIFAYDLLGAHIPPPP", "length": 455, "header": "tr|F1MEJ0-1|F1MEJ0_BOVIN Isoform 1 of Rhomboid-related protein 1 OS=Bos taurus OX=9913 GN=RHBDL1 PE=3 SV=3 CANONICAL=F1MEJ0-1" }, "isoforms": [ { "isoform_ac": "F1MEJ0-1", "url": "https://www.uniprot.org/uniprotkb/F1MEJ0/entry", "sequence": { "sequence": "MGTGSRAPFLPGHVLVRGARVSRPRVAGRAVAAACAAGAGGSVTRRRAERAEPEGRGGAESSAEQPLPAAAADPGPGPRPGSMDRSSLLQLIQEQQLDPENTGFIGADTFTGLVHRHELPLDPAKLDMLVALAQSNERGQVCYQELADLISSKRSSSFKRAIANGQRALPRDGLLDEPGLGVYKRFVRYVAYEILPREVDRHWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPEYMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLAGSLTVSITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVLALVCMSSEVGRAVWLRFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWVVLLAYGTFLLFAIFWNIFAYDLLGAHIPPPP", "length": 455, "header": "tr|F1MEJ0-1|F1MEJ0_BOVIN Isoform 1 of Rhomboid-related protein 1 OS=Bos taurus OX=9913 GN=RHBDL1 PE=3 SV=3 CANONICAL=F1MEJ0-1" }, "locus": { "chromosome": "25", "start_pos": 582394, "end_pos": 579934, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022975.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022975.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022975.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022975.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:100336895", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100336895", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "F1MEJ0", "url": "https://www.uniprot.org/uniprotkb/F1MEJ0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1MEJ0", "url": "https://www.uniprot.org/uniprotkb/F1MEJ0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MEJ0", "url": "https://www.uniprot.org/uniprotkb/F1MEJ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MEJ0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 455, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MEJ0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MEJ0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MEJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEJ0" }, { "id": "PF01694", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01694" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S54 rhomboid", "eco_id": "ECO_0000259", "start_pos": 261, "end_pos": 410, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.21.105", "ec_name": "Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.", "evidence": [ { "id": "3.4.21.105", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.21.105" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MEK2-1", "uniprot_ac": "F1MEK2", "uniprot_id": "F1MEK2_BOVIN", "mass": { "chemical_mass": 66547.0, "monoisotopic_mass": 66547.0 }, "refseq": { "ac": "XP_005217101", "name": "kelch-like protein 21 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217101" }, "gene_names": [ { "name": "KLHL21", "type": "recommended", "evidence": [ { "id": "F1MEK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" } ] }, { "name": "KLHL21", "type": "synonym", "evidence": [ { "id": "XP_005217101", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217101" } ] } ], "protein_names": [ { "name": "Kelch-like protein 21", "type": "recommended", "evidence": [ { "id": "F1MEK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEK2/entry#names_and_taxonomy" } ] }, { "name": "kelch-like protein 21 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005217101", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217101" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MEK2", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KLHL21", "url": "https://www.uniprot.org/uniprotkb/F1MEK2", "locus": { "chromosome": "16", "start_pos": 46815736, "end_pos": 46800207, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008350", "url": "https://www.ensembl.org/id/ENSBTAG00000008350" } ] } } ], "crossref": [ { "id": "F1MEK2", "url": "https://alphafold.ebi.ac.uk/entry/F1MEK2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008350", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008350", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18250", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18250", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18460", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18460", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506632", "url": "https://www.ncbi.nlm.nih.gov/gene/506632", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TWSVVGQ", "url": "https://omabrowser.org/oma/group/TWSVVGQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MEK2", "url": "https://www.orthodb.org/?gene=F1MEK2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24412", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24412", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24412:SF255", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24412:SF255", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8951664", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005217101", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217101", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MEK2", "url": "https://www.uniprot.org/uniprotkb/F1MEK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEK2-1", "url": "https://www.uniprot.org/uniprotkb/F1MEK2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLTNCLDMQDFAEAFSCAGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYHPDMDLWSLVDCGQLPPWSFAPKTVTLNGLMYFIRDDSAEVDVYNPTKNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTPLGGRGFELDGGSSDMDVGQPRPPQNPAELH", "length": 597, "header": "tr|F1MEK2-1|F1MEK2_BOVIN Isoform 1 of Kelch-like protein 21 OS=Bos taurus OX=9913 GN=KLHL21 PE=4 SV=2 CANONICAL=F1MEK2-1" }, "isoforms": [ { "isoform_ac": "F1MEK2-1", "url": "https://www.uniprot.org/uniprotkb/F1MEK2/entry", "sequence": { "sequence": "MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLTNCLDMQDFAEAFSCAGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYHPDMDLWSLVDCGQLPPWSFAPKTVTLNGLMYFIRDDSAEVDVYNPTKNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTPLGGRGFELDGGSSDMDVGQPRPPQNPAELH", "length": 597, "header": "tr|F1MEK2-1|F1MEK2_BOVIN Isoform 1 of Kelch-like protein 21 OS=Bos taurus OX=9913 GN=KLHL21 PE=4 SV=2 CANONICAL=F1MEK2-1" }, "locus": { "chromosome": "16", "start_pos": 46810232, "end_pos": 46800316, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010998.5", "url": "https://www.ensembl.org/id/ENSBTAT00000010998.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010998.4", "url": "https://www.ensembl.org/id/ENSBTAP00000010998.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8951664", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8951664", "resource": "Reactome", "description": "Neddylation" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A2K4-1", "protein_name": "Kelch-like protein 21", "gene_name": "Klhl21", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLNGLLYVVAADSTERYDHATDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVIQCYDPDTDLWSMVNCGQLPPWSFAPKTVTLNGLMYFVRDDSAEVDVYNPTKDEWDKIPSMNQVHVGGSLAALGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTPAGGRGFELNSGSSDVDAGHHRLPQNPEELQ", "length": 597 }, "evidence": [ { "id": "F1MEK2", "url": "https://omabrowser.org/oma/group/F1MEK2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RIK0-1", "protein_name": "Kelch-like protein 21", "gene_name": "KLHL21", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCAGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAVHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYHPDTDLWSLVDCGQLPPWSFAPKTVTLNGLMYFIRDDSAEVDVYNPAKNEWDKIPPMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTPLGGRGFELDGGGSDMDVGRPRPPQNPAELH", "length": 597 }, "evidence": [ { "id": "F1MEK2", "url": "https://omabrowser.org/oma/group/F1MEK2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q3U410-1", "protein_name": "Kelch-like protein 21", "gene_name": "Klhl21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAPHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHATDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVIQCYDPDTDLWSLVNCGQLPPWSFAPKTVTLNGLMYFVRDDSAEVDVYNPTKDEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTPAGGRGFELNSGSNDVDAGYHRLPQNPEELH", "length": 597 }, "evidence": [ { "id": "F1MEK2", "url": "https://omabrowser.org/oma/group/F1MEK2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6NYM1-1", "protein_name": "Kelch-like protein 21", "gene_name": "klhl21", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEKPVLQTQPSMLPFFDTAHAVNLLRGIHELRAERKFFDVTLCAEGKEFHCHRTVLAAASMYFRAMFAGTLRESVMDRVVLHEVSAELLGLLVDFCYTGRVTVTHDNVDLLLKTADLFQFPSVKEACCAFLEQRLDVSNCLEIQDFAEAYACRELAASARRFVLKNIVELAKSMDFERLSWKRLLEFVSDDGLCVDKEETAYQIAVRWVKADLQHRLHYWPELLQQVRLPFVRRFYLLAHVESDPLVYLSPACLRLVSEARSFQSYEYDRHDRPGHRMRPRPSTGLAEILVVVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIAALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVSPMLKAREYHSSCVLKGQLYVVGSDSTERYDHTIDCWEALPPMPHPMDNCSTTACRGRLYAIGSLTGEDTMAIQCYDAESNRWSLLNSGELPPWSFAPKSVTLNGLIYFVRDDSAEVDVYNPQKNEWDKISPMTQVHVGGSVSALGGRLYVSGGYDNTFELSDVVEVYDPSSRSWSPAGRLPQPTFWHGSVSIFRQFMPLVQSTFEPIDIPEANAIHLHRHHRNQALHNHNNNVNQNHNQEVNQVH", "length": 613 }, "evidence": [ { "id": "F1MEK2", "url": "https://omabrowser.org/oma/group/F1MEK2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9UJP4-1", "protein_name": "Kelch-like protein 21", "gene_name": "KLHL21", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTFSGGRGFELDSGSDDMDPGRPRPPRDPDELH", "length": 597 }, "evidence": [ { "id": "F1MEK2", "url": "https://omabrowser.org/oma/group/F1MEK2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "chromosome passenger complex localization to spindle midzone", "id": "GO:0035853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035853", "evidence": [ { "database": "UniProtKB", "id": "F1MEK2", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "F1MEK2", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "F1MEK2", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "F1MEK2", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" } ], "pmid": "" }, { "name": "regulation of cytokinesis", "id": "GO:0032465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032465", "evidence": [ { "database": "UniProtKB", "id": "F1MEK2", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MEK2", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1MEK2", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" } ], "pmid": "" }, { "name": "polar microtubule", "id": "GO:0005827", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005827", "evidence": [ { "database": "UniProtKB", "id": "F1MEK2", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "F1MEK2", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "cullin family protein binding", "id": "GO:0097602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097602", "evidence": [ { "database": "UniProtKB", "id": "F1MEK2", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "F1MEK2", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" } ], "pmid": "" }, { "name": "ubiquitin-like ligase-substrate adaptor activity", "id": "GO:1990756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756", "evidence": [ { "database": "UniProtKB", "id": "F1MEK2", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MEK2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 597, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MEK2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MEK2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MEK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEK2" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 35, "end_pos": 103, "start_aa": "Leu", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 356, "end_pos": 358 }, { "start_pos": 414, "end_pos": 416 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MEL1-1", "uniprot_ac": "F1MEL1", "uniprot_id": "F1MEL1_BOVIN", "mass": { "chemical_mass": 80337.0, "monoisotopic_mass": 80337.0 }, "refseq": { "ac": "XP_024835025", "name": "orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835025" }, "gene_names": [ { "name": "LOC785933", "type": "recommended", "evidence": [ { "id": "F1MEL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEL1" } ] }, { "name": "LOC785933", "type": "synonym", "evidence": [ { "id": "XP_024835025", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835025" } ] } ], "protein_names": [ { "name": "Transporter", "type": "recommended", "evidence": [ { "id": "F1MEL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEL1/entry#names_and_taxonomy" } ] }, { "name": "orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024835025", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835025" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MEL1", "url": "https://www.uniprot.org/uniprotkb/F1MEL1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC785933", "url": "https://www.uniprot.org/uniprotkb/F1MEL1", "locus": {} } ], "crossref": [ { "id": "F1MEL1", "url": "https://alphafold.ebi.ac.uk/entry/F1MEL1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000030502", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030502", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11502", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11502", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "785933", "url": "https://www.ncbi.nlm.nih.gov/gene/785933", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037272", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037272", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785933", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785933", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ISPIYRW", "url": "https://omabrowser.org/oma/group/ISPIYRW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MEL1", "url": "https://www.orthodb.org/?gene=F1MEL1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11616", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11616:SF100", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11616:SF100", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00209", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00209", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024835025", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835025", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MEL1", "url": "https://www.uniprot.org/uniprotkb/F1MEL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEL1-1", "url": "https://www.uniprot.org/uniprotkb/F1MEL1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTVNEDTESQEEKSQLSVPSTSISLTATTSAYQLVSEIPTEESQKFDLSAHVWSDEDNEDILETPNKDGPKYEAPHERPIWANKTEYLLAQVGFSVGLSTIWRFPYLCFHNGGGSFLIIYILMMFLVGIPLLFLEMAAGQRMRQGSIGVWKVISPWIGGVGYTSFMVCIIVGLYYSVLMAWNLFYLVQSFQSPLPWLLCPLSKNSSIDSECARTSPTTYFWYRKVLKATDEIEIDGKPVMHLSASVLVIWLIICISMIKGPKSTGKMLYISVLLPYIILFSLLIRSLTMKGAYFGLKNLLAAKVPALYSVEVWRRTGNQLFLSLGPGFGSFTAISSYIPRSNNCVIDAYAVAFLNLLVSLTTTVFVFAVMGHLATKNNEKCYLMNAEKVMDLVTAQVLPPEAHPPDSLYHDPSAIYPKWLNNLPEHIKSRILPNLTDCDLSKELNKVMIGPGVVIVTFSDIVSLFSGPTFWSIVTFLLLVNLGLSTVIGIIQGIITPLQDTFSSLREHSKLLTVGVCVPMFLGSLLFVRPSGSYYVNLLDDYWVSLPLFFIVILETIAMAWIYGARRFLTDLSIMMGHPISPIYRWLWCFLSPFVLLVLFLSTLIHLSVKEITYLAWDSRISHEVTRIYPSWAKALLIFLVVITVLPVPVYFFYTVIIRVASPVSMSHNTAIITFQPEAKGDSPKVGPRLQVRQKRQKIIKMDKPKTEGKLSFL", "length": 715, "header": "tr|F1MEL1-1|F1MEL1_BOVIN Isoform 1 of Transporter OS=Bos taurus OX=9913 GN=LOC785933 PE=3 SV=3 CANONICAL=F1MEL1-1" }, "isoforms": [ { "isoform_ac": "F1MEL1-1", "url": "https://www.uniprot.org/uniprotkb/F1MEL1/entry", "sequence": { "sequence": 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"field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MEP1-1", "uniprot_ac": "F1MEP1", "uniprot_id": "F1MEP1_BOVIN", "mass": { "chemical_mass": 38965.0, "monoisotopic_mass": 38965.0 }, "refseq": {}, "gene_names": [ { "name": "QNG1", "type": "recommended", "evidence": [ { "id": "F1MEP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEP1" } ] } ], "protein_names": [ { "name": "Queuosine 5'-phosphate N-glycosylase/hydrolase", "type": "recommended", "evidence": [ { "id": "F1MEP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEP1/entry#names_and_taxonomy" } ] }, { "name": "3.2.2.-", "type": "synonym", "evidence": [ { "id": "F1MEP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEP1/entry#names_and_taxonomy" } ] }, { "name": "Queuosine-nucleotide N-glycosylase/hydrolase", "type": "synonym", "evidence": [ { "id": "F1MEP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEP1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.", "evidence": [ { "database": "UniProtKB", "id": "F1MEP1", "url": "https://www.uniprot.org/uniprotkb/F1MEP1#function" }, { "database": "UniProtKB", "id": "RU365002", "url": "https://www.uniprot.org/uniprotkb/RU365002#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MEP1", "url": "https://www.uniprot.org/uniprotkb/F1MEP1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "QNG1", "url": "https://www.uniprot.org/uniprotkb/F1MEP1", "locus": { "chromosome": "8", "start_pos": 77189041, "end_pos": 77200796, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006478", "url": "https://www.ensembl.org/id/ENSBTAG00000006478" } ] } } ], "crossref": [ { "id": "F1MEP1", "url": "https://alphafold.ebi.ac.uk/entry/F1MEP1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006478", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006478", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR019438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FSFWSEE", "url": "https://omabrowser.org/oma/group/FSFWSEE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR21314", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21314", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21314:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21314:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10343", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10343", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6782315", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6782315", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "75387", "url": "https://www.rhea-db.org/rhea/75387", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MEP1", "url": "https://www.uniprot.org/uniprotkb/F1MEP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEP1-1", "url": "https://www.uniprot.org/uniprotkb/F1MEP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGLLTPRESAKFIAENSRDVFIDDGGVRRVAELLLAKATGPELRIGGWKAIHELNPRGTDEAAVNWVFVTDTLNFSFWSESDEYKCQVGFGGKTYSGYWSLCAAVNRALDEGIPITSASYYATVTLDEVRHILRSDTDVPMPLIEERHRILNETGKILLEKFGGSFLNCVQKSDKSAQKLLHLVVENFPSYRDVTQFEGKRISFYKRAQILVADTWSVLEGKGDGCFKDISSITMFADYRLPQVLVYLGALKYSNELLEKLLKGEMLFYGNRQEVEIRGCSVWCVELIRDCLLELIEKKGEKTTGEINSILLDYYLWDYARDHREDMKGIPFHHTRCIYY", "length": 341, "header": "tr|F1MEP1-1|F1MEP1_BOVIN Isoform 1 of Queuosine 5'-phosphate N-glycosylase/hydrolase OS=Bos taurus OX=9913 GN=QNG1 PE=3 SV=1 CANONICAL=F1MEP1-1" }, "isoforms": [ { "isoform_ac": "F1MEP1-1", "url": "https://www.uniprot.org/uniprotkb/F1MEP1/entry", "sequence": { "sequence": "MDGLLTPRESAKFIAENSRDVFIDDGGVRRVAELLLAKATGPELRIGGWKAIHELNPRGTDEAAVNWVFVTDTLNFSFWSESDEYKCQVGFGGKTYSGYWSLCAAVNRALDEGIPITSASYYATVTLDEVRHILRSDTDVPMPLIEERHRILNETGKILLEKFGGSFLNCVQKSDKSAQKLLHLVVENFPSYRDVTQFEGKRISFYKRAQILVADTWSVLEGKGDGCFKDISSITMFADYRLPQVLVYLGALKYSNELLEKLLKGEMLFYGNRQEVEIRGCSVWCVELIRDCLLELIEKKGEKTTGEINSILLDYYLWDYARDHREDMKGIPFHHTRCIYY", "length": 341, "header": "tr|F1MEP1-1|F1MEP1_BOVIN Isoform 1 of Queuosine 5'-phosphate N-glycosylase/hydrolase OS=Bos taurus OX=9913 GN=QNG1 PE=3 SV=1 CANONICAL=F1MEP1-1" }, "locus": { "chromosome": "8", "start_pos": 77200560, "end_pos": 77189606, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008492.5", "url": "https://www.ensembl.org/id/ENSBTAT00000008492.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008492.3", "url": "https://www.ensembl.org/id/ENSBTAP00000008492.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-6782315", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6782315", "resource": "Reactome", "description": "tRNA modification in the nucleus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C455-1", "protein_name": "Queuosine 5'-phosphate N-glycosylase/hydrolase", "gene_name": "QNG1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEALPSPLESARFIAGRSRDVSVDEEGARKVAESLFDKASEAAFGLSGWKSLHELNPRAASEEAVSWVFLVDTLNFSFWSESAEQKCLVRYKGKAYSGYWALCAAVNRALDDGIPITSASYYATMTLDQVRQVFRSDTEVPMPLLEERHRVLNESGTVLLEKFGGSFLTCVKMSENSAQKLLRLVVENFPSYRDEAVFEKKKVSFYKRAQILVADTWSVLEGKGDGFFGDISSLTIFADYRIPQVLVHLKAMKYSEDLMKKLREGTVFKSGDREEVEIRGCSIWCCTLICKHLLDLYEKKGQDMRDQINAVLLDYYLWDYARDHREDMKDIPFHRVRCIYY", "length": 341 }, "evidence": [ { "id": "F1MEP1", "url": "https://omabrowser.org/oma/group/F1MEP1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F7FM32-1", "protein_name": "Queuosine 5'-phosphate N-glycosylase/hydrolase", "gene_name": "Qng1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEAPMPLPPRESARFVAENSRDVGVDREGVRRVAELLLPAAVAWRLEQWKALHELNPRGSDEAALDWVFMVDSLNFSFWAEREERKCEVRYGGTAYTGYWALCAAVNRALDQGIPVTSASYYATVTLDQVRNIFRSDTAVPMPLLEERHRILNETGKILLEKFGGSFLNCVQKSGKSAQKLMHLIVENFPSYRDEAWFEGKRISFYKRAQILVADTWSVLEGKGDGSFEDISSITMFADYRLPQILAHLGALKYSDELLKKLLEGEMLLNGDKQEVEIRGCSIWCVELIRDCLVELLEKRGESPPVEVNAILLDYHLWDYAREHRDGMKGVPFHRTRCIYY", "length": 341 }, "evidence": [ { "id": "F1MEP1", "url": "https://omabrowser.org/oma/group/F1MEP1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3X8U3-1", "protein_name": "Queuosine 5'-phosphate N-glycosylase/hydrolase", "gene_name": "QNG1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGPPLSPRESARFVAENSRDVLVDHEGVRRAAELLLPAAAAWRVEQWKSLHELNPRGADEAALGWVFLVDSLNFSFWAEREDSKCAVRYGGTPYTGYWALCAAVNRALDQGIPITSASYYATVSLEQVRDIFRSDTAVPMPLMEERHRILNETGKILLEKFGGSFLNCVQKSGRSAQKLMQLIVENFPSYRDEAEFEGKRIAFYKRAQILVADTWSVLEGKGDGCFEDISSITMFADYRLPQILVYLGALKYSDELLKKLLKGEMLLNGDKQEVEIRGCSIWCVELIRDRLLELLEKGENSPVEINSVLLDYHLWDYAREHREDMKGVPFHRTRCIYY", "length": 338 }, "evidence": [ { "id": "F1MEP1", "url": "https://omabrowser.org/oma/group/F1MEP1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q54II8-1", "protein_name": "Queuosine 5'-phosphate N-glycosylase/hydrolase", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNPLTLVRETTAWVSGLSKHVKINNEALDKECEDFLNKHKIKAHKEIWADNWFHYCDIDIENKESTFTELTAKYILVLDTLNFCFWPDSEFEYHHLARGLKNALIANPKCFDADQLIKVTSETIHQWFGKDLPNTSERVRLIREVGTVLIEYFNGSIKEMILSANNKASVLVDLVTKYFWGFRDSAIYKGKQVFFYKRAQIFVGDLWGAYQGRGLGKFDDIKQLTMFADYRVPQILEELKVIEYSPELKEMIKNKVEIPVGSEMELEIRAVTVHVVEKMRDYFNKGHCELLALEIDWMLWGRGEAMLDKLPPHHRTLTIFY", "length": 321 }, "evidence": [ { "id": "F1MEP1", "url": "https://omabrowser.org/oma/group/F1MEP1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5T6V5-1", "protein_name": "Queuosine 5'-phosphate N-glycosylase/hydrolase", "gene_name": "QNG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDGLLNPRESSKFIAENSRDVFIDSGGVRRVAELLLAKAAGPELRVEGWKALHELNPRAADEAAVNWVFVTDTLNFSFWSEQDEHKCVVRYRGKTYSGYWSLCAAVNRALDEGIPITSASYYATVTLDQVRNILRSDTDVSMPLVEERHRILNETGKILLEKFGGSFLNCVRESENSAQKLMHLVVESFPSYRDVTLFEGKRVSFYKRAQILVADTWSVLEGKGDGCFKDISSITMFADYRLPQVLAHLGALKYSDDLLKKLLKGEMLSYGDRQEVEIRGCSLWCVELIRDCLLELIEQKGEKPNGEINSILLDYYLWDYAHDHREDMKGIPFHRIRCIYY", "length": 341 }, "evidence": [ { "id": "F1MEP1", "url": "https://omabrowser.org/oma/group/F1MEP1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W2I2-1", "protein_name": "Queuosine 5'-phosphate N-glycosylase/hydrolase", "gene_name": "Dmel\\CG9752", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSSSKLSPRESGAYIVENAKHVRILPAGIEKLTQEIVKGLIEKRIAVENFSQHELHPNPNQPEDYSKAADWVFVLDTLNFCFWTPNNYTKYKVDGYTGYFALCAAIKRAIKEGVDVINPKFYSQIDLKTVENIFRSDDGETVIPLLQKRLESLHEVGKVLIDKYDGSFENVIKKAEKSAVRLLDLVVEEFPCFRDEAEFAGKRVSILKRAQILVGDVWSCYRGQGLGFFNDIDQITMFADYRIPQVLVHFGSLEYTSELMEFLKTDTILENGDPREVEIRGASIYIIEQVRDAVVKILKEQHPEISLDNVNSIVIDQYLWDYRRRHNADLEHIPFHKVLSIYY", "length": 343 }, "evidence": [ { "id": "F1MEP1", "url": "https://omabrowser.org/oma/group/F1MEP1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MEP1", "url": "https://www.uniprot.org/uniprotkb/F1MEP1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "tRNA modification", "id": "GO:0006400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006400", "evidence": [ { "database": "UniProtKB", "id": "F1MEP1", "url": "https://www.uniprot.org/uniprotkb/F1MEP1" } ], "pmid": "" }, { "name": "nucleoside salvage", "id": "GO:0043174", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043174", "evidence": [ { "database": "UniProtKB", "id": "F1MEP1", "url": "https://www.uniprot.org/uniprotkb/F1MEP1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "queuosine nucleosidase activity", "id": "GO:0106432", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106432", "evidence": [ { "database": "UniProtKB", "id": "F1MEP1", "url": "https://www.uniprot.org/uniprotkb/F1MEP1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "75387", "name": "", "equation": "queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q1JP73-1", "F1MEP1-1" ], "evidence": [ { "id": "75387", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/75387" } ] }, { "id": "R-BTA-9942295", "name": "QNG1 hydrolyzes queuosine 5'-monophosphate yielding queuine and ribose 5'-monophosphate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-9942293" ], "output_participant_list": [ "R-ALL-6782431" ], "enzyme_list": [ "F1MEP1-1" ], "evidence": [ { "id": "R-BTA-9942295", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9942295" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-6782431", "participant_name": "queuine [cytosol]", "crossref": [ { "id": "C01449", "database": "COMPOUND", "url": "" }, { "id": "HMDB0001495", "database": "HMDB Metabolite", "url": "" }, { "id": "ZINC000006622451", "database": "ZINC", "url": "" }, { "id": "17433", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-9942293", "participant_name": "queuosine 5'-phosphate [cytosol]", "crossref": [ { "id": "194371", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F1MEP1", "gene_name": "QNG1", "activity": [ { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "F1MEP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEP1" } ] } ] }, { "uniprot_ac": "Q1JP73", "gene_name": "QNG1", "activity": [ { "ec_number": "3.2.2.-", "activity": "", "evidence": [ { "id": "Q1JP73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JP73" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MEP1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 341, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MEP1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MEP1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 153, "end_pos": 155 }, { "start_pos": 75, "end_pos": 77 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376846" }, "gene_names": [ { "name": "OR1M1", "type": "recommended", "evidence": [ { "id": "F1MEP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEP2" } ] }, { "name": "OR1M1", "type": "synonym", "evidence": [ { "id": "NP_001376846", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376846" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1MEP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEP2/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 1M1", "type": "synonym", "evidence": [ { "id": "NP_001376846", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376846" } ] }, { "name": "olfactory receptor 24", "type": "synonym", "evidence": [ { "id": "NP_001376846", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376846" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376846" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MEP2", "url": "https://www.uniprot.org/uniprotkb/F1MEP2#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MEP2", "url": "https://www.uniprot.org/uniprotkb/F1MEP2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR1M1", "url": "https://www.uniprot.org/uniprotkb/F1MEP2", "locus": { "chromosome": "7", "start_pos": 13406810, "end_pos": 13407751, "strand": "+", "evidence": [ 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"bta:513175", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513175", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IIMAIMK", "url": "https://omabrowser.org/oma/group/IIMAIMK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MEP2", "url": "https://www.orthodb.org/?gene=F1MEP2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48001", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48001", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376846", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MEP2", "url": "https://www.uniprot.org/uniprotkb/F1MEP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEP2-1", "url": "https://www.uniprot.org/uniprotkb/F1MEP2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METDNQTSSSEFIRLGLSEKPEQETLLFALFLCMYVVTVVGNLLIILAISTDSHLHTPMYFFLANLSLVDFCLASDTVPKMLVSIQIKSKSISYSCCLTQMYFFHFFGIMDSVLIAVMAYDRFVAICHPLHYTSIMSPRLCVLLVGGPWVFSGFISLTHILLMARLVFCGNIELPHYFCDLTPLLRLSCTDTSVNKIFVLIVAGMIIATPFICILASYAHIIVAIVKVPSAGGRKKTFSTCSSHLSVVVLFYGTTIGVYLCPSSVRTAVKEKASAVMYTAVTPMLNPFIYSLRNRDLKGALMKLVNRKITSSS", "length": 313, "header": "tr|F1MEP2-1|F1MEP2_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR1M1 PE=3 SV=2 CANONICAL=F1MEP2-1" }, "isoforms": [ { "isoform_ac": "F1MEP2-1", "url": "https://www.uniprot.org/uniprotkb/F1MEP2/entry", "sequence": { "sequence": 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], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 282, "start_aa": "Thr", "end_pos": 282, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr282", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:513175", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513175", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZM97-1", "protein_name": "Olfactory receptor", "gene_name": "Or1m1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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}, "evidence": [ { "id": "F1MEP2", "url": "https://omabrowser.org/oma/group/F1MEP2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3L6T3-1", "protein_name": "Olfactory receptor", "gene_name": "R1C1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEPNNQTSVSEFILLGLSEKPEQETLLFALFLCMYVVTVAGNLLIILAISSDPHLHTPMYFFLANLSLVDFCLATNTVPKMLVNIQIRSKSISYPCCLTQMYFFHFFGIMDSVLIAVMAYDRFVAICHPLHYTTIMSPQLCGLLAGGLWMLSCFISLTHILLMARLVFCGNNKIPHYFCDLTPLLRLSCTDTSVNKIFVLIVAGMVIATPFICILASYVRIIVAIMKVPSAGGRKKAFSTCSSHLSVVALFYGTTIGVYLCPSSVRTAVKEKASAVMYTAVTPMLNPFIYSLRNRDLKGALRKLVNRKITSSS", "length": 313 }, "evidence": [ { "id": "F1MEP2", "url": "https://omabrowser.org/oma/group/F1MEP2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8NGA1-1", "protein_name": "Olfactory receptor 1M1", "gene_name": "OR1M1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZKR9-1", "protein_name": "CWC25 spliceosome associated protein homolog", "gene_name": "CWC25", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGGGDLNLKKSWHPQTLRNVEKVWKAEQKHEAERKKIEELQRELREERAREEMQRYAEDVGAVKKKEEKLDWMYQGPGGMVNRDEYLLGRPIDKYVFEKMEEKEAGCSSETGLLPGSIFAPSGANSLLDMASKIREDPLFIIRKKEEEKKREVLNNPVKMKKIKELLQMSLVKKEKKKKKEKKKKHKKHKHRGSSSDRCSSEDERGRGRSQKKLANSSPVLAKVPGYGLQLRNSDRSQGPRGPPVAEQRAGHGLKNYSRSRSSSPSPPRHASKKSTREAGSRDRRSRSPGRRSRSPRPSKPHNSKVSRRDRGRTKSPSPKKEVYQRRHAPGYTRKLSSEELERKRQEMMENAKWREAERLNILKRHAKDDEREQRLQKLDSRDGKFLHRMKLESASTSSLEDRVKRNIYSLQRTSVALEKNFMKR", "length": 425 }, "evidence": [ { "id": "F1MER3", "url": "https://omabrowser.org/oma/group/F1MER3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E1BYR4-1", "protein_name": "CWC25 spliceosome associated protein homolog", "gene_name": "CWC25", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGGGDLNLKKSWHPQTLRNVEKVWKAEQKYEAERKKIEELQRELQEERAREEMQRYAEDMGTVRKREEKLEWMYQGPGGMVNREEYLMGRPVDKYVFEKTEDKDAGCSNETGLLPGSIFAKSGANSVLDMANKIREDPLFMIRKREEEKKREVLNNPVKMKKIKELLQNSLDKKEKKKKKEKKKKHKKHRRHSSSSESASSDEERSKARSQKKTNNSSWKPIPSKVPGYGLQVRDSDRNHRSRSSPVAGQGRTPHKHREHSRSRSTSRSPQRCTGKKSTEPSGCRGSRSPSRHSKQHSSREEKGKARSPSPKKSYRRQHIPGYTRKISAEELERKRQEMMENAKWREEERVNNLKKHRKEEELERELEKLDSRDGKFLHNFKLESASTSTLEDRVKRNIHSLQRTPAALEKNFMQR", "length": 416 }, "evidence": [ { "id": "F1MER3", "url": "https://omabrowser.org/oma/group/F1MER3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3H5W3-1", "protein_name": "Pre-mRNA-splicing factor CWC25 homolog", "gene_name": "Cwc25", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGGGDLNLKKSWHPQTLRNVEKVWKAEQKHEAERKKIEELQRELREERAREEMQRYAEDVGAVKKKEEKLDWMYQGPGGMVNRDEYLLGRPIDKYVFEKMEEKEAGCSSETGLLPGSIFAPSGANSLLDMASKIREDPLFIIRKKEEEKKREVLNNPVKMKKIKELLQMSLEKKEKKKKKEKKKKHKKHKHRSSSSDGSSSEEEHSQGRSQKKMANSFPVLSKVPGYGLQVRDSDRNQGLQGSLMAEQRGVKNHSRSRSSSHSPPRHVSKKSSKEERSRDRRSRSPGRRSRSPRPSKPHASKVNRKERDSPSPKKEVYQRRHSSGYTRKLSAEELERKRQEMMENAKWREEERLNTLKRHAKEDERERRLEKLDSRSGKFIHRMKLESASTSSLEDRVKRNIHSLQRTSVALEKNFMKR", "length": 419 }, "evidence": [ { "id": "F1MER3", "url": "https://omabrowser.org/oma/group/F1MER3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3V6I3-1", "protein_name": "CWC25 spliceosome-associated protein homolog", "gene_name": "Cwc25", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGGGDLNLKKSWHPQTLRNVEKVWKAEQKHEAERKKIEELQRELREERAREEMQRYAEDVGAVKKKEEKLDWMYQGPGGMVSRDEYLLGRPIDKYVFEKMEEREAGCSSETGLLPGSIFAPSGANSLLDMASKIREDPLFIIRKKEEEKKREVLNNPVKMRKIKELLQMSLEKKEKKKKKEKKKKHRKHKHRSSSSDRSSSEDEQSHGRSQKKMANSFPVLSKVPGYGLQVRDSDRNQGLQGSLGEQRAVKNHSRSSSSPARHASRKSTKEERSRDRRSRSPGRKSLSPRPSKQHTSKANRKERDSPSPKKEVYQRRHASGYTRKLSAEELERKRQEMMENAKWREEERLNTLKRHAKEDEQEHRLERLDSRSGKFIHRMKLESASTSSLEDRVKRNIHSLQRTSMALEKNFMRR", "length": 415 }, "evidence": [ { "id": "F1MER3", "url": "https://omabrowser.org/oma/group/F1MER3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O64855-1", "protein_name": "Pre-mRNA splicing factor domain-containing protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGMKFLNKKGWHTGSLRNIETVWKAEQKQEAEQKKLEELRLQILQERERSEFRALQEQAGLIPRQERLEFLYDSGLAVGKGSASGSGVSFQKEEQPLAKSEAGSSASEKPDQSAPGALFEEKAQSANDSWRKLHSDPLLLIRQREQEALAKIKNNPVKMALIRKSVEEKGKGKDGDTKEHKKKHKRKSGKHQKQSSSRQRSDSEEDSGEENNGRKSHHQKTSGTHDRHYERPRSDLEDESKGRESRDRHYEKRRSELDDGHKRRERHDTHYERRRSEMDDESKRRESRDNHYERRRSDLDDESKRRESHDKHFERQRSDLDDEYKRRESQDKRRRSDIDDEPKRRDARPNEKYRNRSPKGGVERENLKSYGQEDKKRKAEDLDSGKPNEYQNRRRKGGSKLSEEERAARLKQMQMDAEVHEEQRWTRLKKADETDAVEADKNKVSTGKSFLDDANKSVYGVEKGGSSTIEESVRRRSYYSQRGTAAEGNAFRR", "length": 493 }, "evidence": [ { "id": "F1MER3", "url": "https://omabrowser.org/oma/group/F1MER3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q54QF2-1", "protein_name": "CBF1-interacting co-repressor CIR N-terminal domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSKSFLSKKSWHVSTMKNQERIWKAEKEKEDEQKKIDQLKKEMREEEQIRDLKNQFNEASGKYVKPDNKMDWMYEGAFQLSMKKTETVDDYLLGKKIDDSAEDIIKKAAQLPGALFLHSNSNDNPQDIKSLVREDPLMIIERKKQEALDKIMNNPLQMKKLEKEKKESDKILKKLKKKEKNEKKEKKEKKEKKEKKEKKKDKNYSSDDDDDDDDDNNDSENDKEKTEKKKDKYKDKDKNNEKIQNSNGHTEKPKNYNDNGGRVDDERRDDRYRDRDHSDRRDDRNRDSEKEKERERRDDRDRDRERNRDSHYDRRDDRDRDRDRDRDRRDERERRDDRDRERNRDHHYDRDRDRRDDRDRRDDKDRDTYHHHHHHHQERRDDRYRDRDHSDRYYDRNRRDEKDHHIDKKREDSRYRDRDHNDSPNKKRDRNDYENRPSNGGLSEEEKRKRIEEMKQSGLQREEERLKKSKNDEDEKDYVPKSLEDRGKTFLEYVF", "length": 495 }, "evidence": [ { "id": "F1MER3", "url": "https://omabrowser.org/oma/group/F1MER3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9DBF7-1", "protein_name": "Pre-mRNA-splicing factor CWC25 homolog", "gene_name": "Cwc25", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGGGDLNLKKSWHPQTLRNVEKVWKAEQKHEAERKKIEELQRELREERAREEMQRYAEDVGAVKKKEEKLDWMYQGPGGMVNRDEYLLGRPIDKYVFEKMEEREAGCSSETGLLPGSIFAPSGANSLLDMASKIREDPLFIIRKKEEEKKREVLNNPVKMKKIKELLQMSLEKKEKKKKKEKKKKHRKHKHRSSSSGGSSSEDEQSQARSQKKMANSFPVLSKVPGYGLQVRDSDRNRGLQGSLGEQRAIKNNSRSRSSSPPRHASKKSTKEERPRDRRSRSPSRRSRSPRPSKPHTSKVNRKERDSPSPKKEAYQRRHASGYTRKLSAEELERKRQEMMENAKWREEERLNTLKRHAREDEREHRLERLDSRSGKFLHRMKLESASTSSLEDRVKRNIHSLQRTSVALEKNFMRR", "length": 416 }, "evidence": [ { "id": "F1MER3", "url": "https://omabrowser.org/oma/group/F1MER3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NXE8-1", "protein_name": "Pre-mRNA-splicing factor CWC25 homolog", "gene_name": "CWC25", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGGGDLNLKKSWHPQTLRNVEKVWKAEQKHEAERKKIEELQRELREERAREEMQRYAEDVGAVKKKEEKLDWMYQGPGGMVNRDEYLLGRPIDKYVFEKMEEKEAGCSSETGLLPGSIFAPSGANSLLDMASKIREDPLFIIRKKEEEKKREVLNNPVKMKKIKELLQMSLEKKEKKKKKEKKKKHKKHKHRSSSSDRSSSEDEHSAGRSQKKMANSSPVLSKVPGYGLQVRNSDRNQGLQGPLTAEQKRGHGMKNHSRSRSSSHSPPRHASKKSTREAGSRDRRSRSLGRRSRSPRPSKLHNSKVNRRETGQTRSPSPKKEVYQRRHAPGYTRKLSAEELERKRQEMMENAKWREEERLNILKRHAKDEEREQRLEKLDSRDGKFIHRMKLESASTSSLEDRVKRNIYSLQRTSVALEKNFMKR", "length": 425 }, "evidence": [ { "id": "F1MER3", "url": "https://omabrowser.org/oma/group/F1MER3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VQF5-1", "protein_name": "Cwc25", "gene_name": "Cwc25", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGGGDLNLKKSWHPHTMKNQERVWKAEEQAKMEERKLQDLRKEINEERDREELRRLGESSGVLSNNGGAAGEAKLEWMYKNSTELINREEYLLGRKIDKSFETLQAEESRQEQNTVGLKQTINHVEHDCVPFSIRTYRNVQSNEQVDIQRKTLEDPLMLIKQREMESRRKLLENPVKLKEIHRILKTEQEQKAAEGKKKNKKNKKSKKSKKKKKNRRSSNEESSDSESNDSDDDLDRKLARQVSKLKGDQGDLKLDKLLDAKYRTISNQLDMATKKKKSKKSKKKKSSDSSDESSDEEEEPRRKHKRSHSSEDRNQRERRRSRSPRDRKKRQSRSPEQRQRQRSPEERRERRRSRSRSPLARRQRRTRSPEDRKARRQSKDTSKQREKRRSRTPEERSRSKRSRSRSSKGDDKRRIAERPPPSRPTGKPKLSEADREARLREMMDNATWREADRSQVVRKHREAYAREEAQNRERDFDKEFINKEVKKAIANHNSIGDRIRANLNNIQRTASSMDSNFARK", "length": 521 }, "evidence": [ { "id": "F1MER3", "url": "https://omabrowser.org/oma/group/F1MER3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1MER3", "url": "https://www.uniprot.org/uniprotkb/F1MER3" } ], "pmid": "" }, { "name": "U2-type catalytic step 1 spliceosome", "id": "GO:0071006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071006", "evidence": [ { "database": "UniProtKB", "id": "F1MER3", "url": "https://www.uniprot.org/uniprotkb/F1MER3" } ], "pmid": "" }, { "name": "U2-type spliceosomal complex", "id": "GO:0005684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005684", "evidence": [ { "database": "UniProtKB", "id": "F1MER3", "url": "https://www.uniprot.org/uniprotkb/F1MER3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splicing, via spliceosome", "id": "GO:0000398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "evidence": [ { "database": "UniProtKB", "id": "F1MER3", "url": "https://www.uniprot.org/uniprotkb/F1MER3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MER3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 425, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MER3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MER3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MER3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MER3" }, { "id": "SM01083", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01083" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CBF1-interacting co-repressor CIR N-terminal", "eco_id": "ECO_0000259", "start_pos": 11, "end_pos": 47, "start_aa": "Ser", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 256, "end_pos": 258 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MES1-1", "uniprot_ac": "F1MES1", "uniprot_id": "F1MES1_BOVIN", "mass": { "chemical_mass": 66284.0, "monoisotopic_mass": 66284.0 }, "refseq": {}, "gene_names": [ { "name": "ACSM3", "type": "recommended", "evidence": [ { "id": "F1MES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MES1" } ] } ], "protein_names": [ { "name": "medium-chain acyl-CoA ligase", "type": "recommended", "evidence": [ { "id": "F1MES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MES1/entry#names_and_taxonomy" } ] }, { "name": "6.2.1.2", "type": "synonym", "evidence": [ { "id": "F1MES1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MES1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MES1", "url": "https://www.uniprot.org/uniprotkb/F1MES1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ACSM3", "url": "https://www.uniprot.org/uniprotkb/F1MES1", "locus": { "chromosome": "25", "start_pos": 18540009, "end_pos": 18483523, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006447", "url": "https://www.ensembl.org/id/ENSBTAG00000006447" } ] } } ], "crossref": [ { "id": "F1MES1", "url": "https://alphafold.ebi.ac.uk/entry/F1MES1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006447", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006447", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05928", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05928", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MES1", "url": "https://www.orthodb.org/?gene=F1MES1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43605", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43605", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43605:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43605:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "48340", "url": "https://www.rhea-db.org/rhea/48340", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MES1", "url": "https://www.uniprot.org/uniprotkb/F1MES1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MES1-1", "url": "https://www.uniprot.org/uniprotkb/F1MES1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TLALVTMKILLCAKYFQCPVIPGSMRALHKDYRTVTPQNFSNYESMKQDFKLEIPEYFNFAKDVLDQWTSMEKAGKKPSNPAFWWTNGNGEEVRWSFEELGSLSRKFANILTEACGLQRGDRVILLLPRIPEWWLANIACLRTGTVLIPGTTQMTQKDILYRLQSSKAKCIITNEVLAPAVDAVASKCENLHSKLIVSQSPREGWENLKEMMKHASDNHTCVKTKHNEMMAIFFTSGTSGYPKMTGHTHSSFGLGLSINGRFWLDLTPLDVMWNTSDTGWAKSAWSSVFSPWIQGACVFAHYLPRFEPTSILQTLSKFPITVFCSAPTAYRMLVQNDKASYKFKSLKHCVSAGEPINPEVTEQWRNRTGLDIYEGYGQTETVLICGNFKGMKIKPGSMGKPSPAFDVKILDVNGNVLPPGKEGDIGIRVRPNRPLGLFTHYIDNPTKTASTLRGNFYITGDRGYMDEDGYFWFVSRADDIILSSGYRIGPFEVESALIEHPAVAESAVVSSPDPIRGEVVKAFIVLNPDYKSHDQEQLKKEIQEHVKRNTAPYKYPRKVEFIQELPKTISGKIKRNELRKKEWETI", "length": 586, "header": "tr|F1MES1-1|F1MES1_BOVIN Isoform 1 of medium-chain acyl-CoA ligase OS=Bos taurus OX=9913 GN=ACSM3 PE=3 SV=3 CANONICAL=F1MES1-1" }, "isoforms": [ { "isoform_ac": "F1MES1-1", "url": "https://www.uniprot.org/uniprotkb/F1MES1/entry", "sequence": { "sequence": 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"id": "F1MES3", "url": "https://alphafold.ebi.ac.uk/entry/F1MES3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006445", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006445", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR006693", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006693", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WSRRNLY", "url": "https://omabrowser.org/oma/group/WSRRNLY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MES3", "url": "https://www.orthodb.org/?gene=F1MES3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11005", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11005", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04083", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04083", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-192456", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-192456", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "12044", "url": "https://www.rhea-db.org/rhea/12044", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "39931", "url": "https://www.rhea-db.org/rhea/39931", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40047", "url": "https://www.rhea-db.org/rhea/40047", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MES3", "url": "https://www.uniprot.org/uniprotkb/F1MES3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MES3-1", "url": "https://www.uniprot.org/uniprotkb/F1MES3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWWLLVTVCFIHMSGNAFCFLGKIAKNPEASMNVSQMISYWGYPSEMHKVITADGYILQVYRIPHGKNNANHLGQRPVVFLQHGLLGSATNWISNLPKNSLGFLLADAGYDVWLGNSRGNTWAQEHLYYSPDSPEFWAFSFDEMAEYDLPSTIDFILRRTGQKKLHYVGHSQGTTIGFIAFSTNPTLAEKIKVFYALAPVATVKYTKSLFNKLALIPHFLFKIIFGDKMFYPHTFLEQFLGVEMCSRETLDVLCKNALFAITGVDNKNFNMSRLDVYIAHNPAGTSVQNTLHWRQAVKSGKFQAFDWGAPYQNLMHYHQPTPPIYNLTAMNVPIAVWSADNDLLADPQDVDLLLSKLSNLIYHKEIPNYNHLDFIWAMDAPQEVYNEIVSLMAEDKK", "length": 397, "header": "tr|F1MES3-1|F1MES3_BOVIN Isoform 1 of Lipase OS=Bos taurus OX=9913 GN=LIPF PE=3 SV=3 CANONICAL=F1MES3-1" }, "isoforms": [ { "isoform_ac": "F1MES3-1", "url": "https://www.uniprot.org/uniprotkb/F1MES3/entry", "sequence": { "sequence": "MWWLLVTVCFIHMSGNAFCFLGKIAKNPEASMNVSQMISYWGYPSEMHKVITADGYILQVYRIPHGKNNANHLGQRPVVFLQHGLLGSATNWISNLPKNSLGFLLADAGYDVWLGNSRGNTWAQEHLYYSPDSPEFWAFSFDEMAEYDLPSTIDFILRRTGQKKLHYVGHSQGTTIGFIAFSTNPTLAEKIKVFYALAPVATVKYTKSLFNKLALIPHFLFKIIFGDKMFYPHTFLEQFLGVEMCSRETLDVLCKNALFAITGVDNKNFNMSRLDVYIAHNPAGTSVQNTLHWRQAVKSGKFQAFDWGAPYQNLMHYHQPTPPIYNLTAMNVPIAVWSADNDLLADPQDVDLLLSKLSNLIYHKEIPNYNHLDFIWAMDAPQEVYNEIVSLMAEDKK", "length": 397, "header": "tr|F1MES3-1|F1MES3_BOVIN Isoform 1 of Lipase OS=Bos taurus OX=9913 GN=LIPF PE=3 SV=3 CANONICAL=F1MES3-1" }, "locus": { "chromosome": "26", "start_pos": 10355806, "end_pos": 10344661, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008453.6", "url": "https://www.ensembl.org/id/ENSBTAT00000008453.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008453.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008453.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-192456", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-192456", "resource": "Reactome", "description": "Digestion of dietary lipid" } ], "orthologs": [ { "uniprot_canonical_ac": "P04634-1", "protein_name": "Gastric triacylglycerol lipase", "gene_name": "Lipf", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWLLLITSVISTFGGAHGLFGKLGPGNPEANMNISQMITYWGYPCQEYEVVTEDGYILGVYRIPHGKNNSENIGKRPVVYLQHGLIASATNWIANLPNNSLAFMLADAGYDVWLGNSRGNTWSRKNVYYSPDSVEFWAFSFDEMAKYDLPATINFIVQKTGQEKIHYVGHSQGTTIGFIAFSTNPTLAKKIKTFYALAPVATVKYTQSPLKKISFIPTFLFKLMFGKKMFLPHTYFDDFLGTEVCSREVLDLLCSNTLFIFCGFDKKNLNVSRFDVYLGHNPAGTSVQDFLHWAQLVRSGKFQAFNWGSPSQNMLHYNQKTPPEYDVSAMTVPVAVWNGGNDILADPQDVAMLLPKLSNLLFHKEILAYNHLDFIWAMDAPQEVYNEMISMMAED", "length": 395 }, "evidence": [ { "id": "F1MES3", "url": "https://omabrowser.org/oma/group/F1MES3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P07098-1", "protein_name": "Gastric triacylglycerol lipase", "gene_name": "LIPF", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK", "length": 398 }, "evidence": [ { "id": "F1MES3", "url": "https://omabrowser.org/oma/group/F1MES3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q67ZU1-1", "protein_name": "Triacylglycerol lipase 2", "gene_name": "LIP2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAGSVMVPSVSIGLALSVLIFFALSLKTLEARGTFGRLAGQPPQRTAAGGICASSVHIFGYKCEEHDVVTQDGYILNMQRIPEGRAGAVAGDGGKRQPVLIQHGILVDGMSWLLNPADQNLPLILADQGFDVWMGNTRGTRFSRRHKYLNPSQRAFWNWTWDELVSYDLPAMFDHIHGLTGQKIHYLGHSLGTLIGFASFSEKGLVDQVRSAAMLSPVAYLSHMTTVIGDIAAKTFLAEATSILGWPEFNPKSGLVGDFIKAICLKAGIDCYDLVSVITGKNCCLNASTIDLFLANEPQSTSTKNMIHLAQTVRDKELRKYNYGSSDRNIKHYGQAIPPAYNISAIPHELPLFFSYGGLDSLADVKDVEFLLDQFKYHDIDKMNVQFVKDYAHADFIMGVTAKDVVYNQVATFFKRQA", "length": 418 }, "evidence": [ { "id": "F1MES3", "url": "https://omabrowser.org/oma/group/F1MES3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9CPP7-1", "protein_name": "Gastric triacylglycerol lipase", "gene_name": "Lipf", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWLLLVTSVLSAFGGAHGLFGKLGPKNPEANMNVSQMITYWGYPSEEYEVVTEDGYILGVYRIPYGKKNSENIGKRPVAYLQHGLIASATNWITNLPNNSLAFILADAGYDVWLGNSRGNTWSRKNVYYSPDSVEFWAFSFDEMAKYDLPATIDFIVQKTGQEKIHYVGHSQGTTIGFIAFSTNPALAKKIKRFYALAPVATVKYTESPFKKISLIPKFLLKVIFGNKMFMPHNYLDQFLGTEVCSRELLDLLCSNALFIFCGFDKKNLNVSRFDVYLGHNPAGTSTQDLFHWAQLAKSGKLQAYNWGSPLQNMLHYNQKTPPYYDVSAMTVPIAVWNGGHDILADPQDVAMLLPKLPNLLYHKEILPYNHLDFIWAMDAPQEVYNEIVTMMAED", "length": 395 }, "evidence": [ { "id": "F1MES3", "url": "https://omabrowser.org/oma/group/F1MES3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "F1MES3", "url": "https://www.uniprot.org/uniprotkb/F1MES3" } ], "pmid": "" }, { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "F1MES3", "url": "https://www.uniprot.org/uniprotkb/F1MES3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "triacylglycerol lipase activity", "id": "GO:0004806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004806", "evidence": [ { "database": "UniProtKB", "id": "F1MES3", "url": "https://www.uniprot.org/uniprotkb/F1MES3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 270, "end_pos": 272, "annotation": "n_glycosylation_sequon" }, { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" }, { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12044", "name": "", "equation": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A5PK46-1", "A0A3Q1LV96-1", "A0A3Q1MLE6-1", "Q3SZ79-1", "E1BJQ9-1", "Q5EA42-1", "P11151-1", "P16386-1", "P30122-1", "Q29458-1", "Q2KI18-1", "F1MC21-1", "Q0P5B7-1", "A0A3Q1M7B8-1", "F6RA94-1", "G5E5T0-1", "A0A3Q1LR40-1", "A0AAA9S3G3-1", "A0ABI0NMZ2-1" ], "evidence": [ { "id": "12044", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12044" } ] }, { "id": "39931", "name": "", "equation": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29458-1" ], "evidence": [ { "id": "39931", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39931" } ] }, { "id": "40047", "name": "", "equation": "1,2,3-trioctanoylglycerol + H2O = 1,2-dioctanoyl-sn-glycerol + octanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q29458-1" ], "evidence": [ { "id": "40047", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40047" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LR40", "gene_name": "LIPG", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LR40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR40" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LR40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR40" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "A0A3Q1LR40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR40" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "A0A3Q1LR40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR40" } ] } ] }, { "uniprot_ac": "A0A3Q1LV96", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] } ] }, { "uniprot_ac": "A0A3Q1M7B8", "gene_name": "PNLIPRP1", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1M7B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7B8" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "A0A3Q1M7B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7B8" } ] } ] }, { "uniprot_ac": "A0A3Q1MLE6", "gene_name": "LIPE", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "A0A3Q1MLE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLE6" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = glycerol + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1MLE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLE6" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "A0A3Q1MLE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLE6" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "A0A3Q1MLE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLE6" } ] } ] }, { "uniprot_ac": "A0AAA9S3G3", "gene_name": "LOC100297709", "activity": [ { "ec_number": "2.3.1.51", "activity": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA.", "evidence": [ { "id": "A0AAA9S3G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3G3" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9S3G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3G3" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9S3G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3G3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A0AAA9S3G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3G3" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "A0AAA9S3G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3G3" } ] }, { "ec_number": "2.3.1.51", "activity": "", "evidence": [ { "id": "A0AAA9S3G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S3G3" } ] } ] }, { "uniprot_ac": "A0ABI0NMZ2", "gene_name": "PNPLA3", "activity": [ { "ec_number": "2.3.1.51", "activity": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA.", "evidence": [ { "id": "A0ABI0NMZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMZ2" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0ABI0NMZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMZ2" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "A0ABI0NMZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMZ2" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ 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"MKTPADTGFAFPDWAYKPESSPGSRQIQLWHFILELLRKEEYQGVIAWQGDYGEFVIKDPDEVARLWGVRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVLVNYPFIDVGLAGGAVPQSAPPVPTGGSHFRFPPSTPSEVLSPTEDPRSPPACSSSSSSLFSAVVARRLGRGSVSDCSDGTSELEEPLGEDPRARPPGPPELGAFRGPPLARLPHDPGVFRVYPRPRGGPEPLSPFPVSPLAGPGSLLPPQLSPALPMTPTHLAYTPSPTLSPMYPGGGGGPSGSGGGSHFSFSPEDMKRYLQAHTQSVYNYHLSPRAFLHYPGLVVPQPQRPDKCPLPPMAPETPPVPSSASSSSSSSPFKFKLQPPPLGRRQRAAGEKALAGADKGSGLALSGAGGLAEGAGALAPPPPPPPPQIKVEPISEGESEEVEVTDISDEDEEDGEVFKTPRVPPAPPKPDPGEAPGVAQCMPLKLRFKRRWSEDCRLEGGGGPAGGLEDEGEDKKVRGEGPGEAGGPLTPRRVSSDLQHATAQLSLEHRDS", "length": 552, "header": "tr|F1MET2-1|F1MET2_BOVIN Isoform 1 of ETS2 repressor factor OS=Bos taurus OX=9913 GN=ERF PE=3 SV=2 CANONICAL=F1MET2-1" }, "isoforms": [ { "isoform_ac": "F1MET2-1", "url": "https://www.uniprot.org/uniprotkb/F1MET2/entry", "sequence": { "sequence": "MKTPADTGFAFPDWAYKPESSPGSRQIQLWHFILELLRKEEYQGVIAWQGDYGEFVIKDPDEVARLWGVRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVLVNYPFIDVGLAGGAVPQSAPPVPTGGSHFRFPPSTPSEVLSPTEDPRSPPACSSSSSSLFSAVVARRLGRGSVSDCSDGTSELEEPLGEDPRARPPGPPELGAFRGPPLARLPHDPGVFRVYPRPRGGPEPLSPFPVSPLAGPGSLLPPQLSPALPMTPTHLAYTPSPTLSPMYPGGGGGPSGSGGGSHFSFSPEDMKRYLQAHTQSVYNYHLSPRAFLHYPGLVVPQPQRPDKCPLPPMAPETPPVPSSASSSSSSSPFKFKLQPPPLGRRQRAAGEKALAGADKGSGLALSGAGGLAEGAGALAPPPPPPPPQIKVEPISEGESEEVEVTDISDEDEEDGEVFKTPRVPPAPPKPDPGEAPGVAQCMPLKLRFKRRWSEDCRLEGGGGPAGGLEDEGEDKKVRGEGPGEAGGPLTPRRVSSDLQHATAQLSLEHRDS", "length": 552, "header": "tr|F1MET2-1|F1MET2_BOVIN Isoform 1 of ETS2 repressor factor OS=Bos taurus OX=9913 GN=ERF PE=3 SV=2 CANONICAL=F1MET2-1" }, "locus": { "chromosome": "18", "start_pos": 51028106, "end_pos": 51021534, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000437.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000437.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000437.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000437.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:789798", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:789798", "resource": "KEGG Pathway" }, { "id": "R-BTA-2559585", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559585", "resource": "Reactome", "description": "Oncogene Induced Senescence" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0LUR4-1", "protein_name": "Ets2 repressor factor", "gene_name": "Erf", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGGGCRGSLFVLPPLTDSAPLSAGRLFPPPLSSPPSCSSLRGQGSPPPPIAGRGAAGLTPPSHSDFPPSPPPPPPGLHRLDFAPGRAGGRGPRRPLPVCPVGIRPGAGTREGEGGRAPLFKLVSFPRRRPRLRLLCAGFAFPDWAYKPESSPGSRQIQLWHFILELLRKEEYQGVIAWQGDYGEFVIKDPDEVARLWGVRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVLVNYPFIDVGLAGGAVPQSAPPVPSGGSHFRFPPSTPSEVLSPTEDPRSPPACSSSSSSLFSAVVARRLGRGSVSDCSDGTSELEEPLGEDPRARPPGPPELGAFRGPPLARLPHDPGVFRVYPRPRGGPEPLSPFPVSPLAGPGSLLPPQLSPALPMTPTHLAYTPSPTLSPMYPSGGGGPSGSGGGSHFSFSPEDMKRYLQAHTQSVYNYHLSPRAFLHYPGLVVPQPQRPDKCPLPPMAPETPPVPSSASSSSSSSSSPFKFKLQPPPLGRRQRAAGEKAPGGTDKSSDGSGSGGLAEGAGALAPPPPPPPQIKVEPISEGESEEVEVTDISDEDEEDGEVFKTPRAPPAPPKPEPGEAPGAAQCMPLKLRFKRRWSEDCRLEGGGCLSGGPEDEGEDKKVRGDMGPGEPGGPLTPRRVSSDLQHATAQLSLEHRDS", "length": 682 }, "evidence": [ { "id": "F1MET2", "url": "https://omabrowser.org/oma/group/F1MET2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P70459-1", "protein_name": "ETS domain-containing transcription factor ERF", "gene_name": "Erf", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTPADTGFAFPDWAYKPESSPGSRQIQLWHFILELLRKEEYQGVIAWQGDYGEFVIKDPDEVARLWGVRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKLVLVNYPFIDMGLAGGAVPQSAPPVPSGGSHFRFPPSTPSEVLSPTEDPRSPPACSSSSSSLFSAVVARRLGRGSVSDCSDGTSELEEPLGEDPRARPPGPPELGAFRGPPLARLPHDPGVFRVYPRPRGGPEPLSPFPVSPLAGPGSLLPPQLSPALPMTPTHLAYTPSPTLSPMYPSGGGGPSGSGGGSHFSFSPEDMKRYLQAHTQSVYNYHLSPRAFLHYPGLVVPQPQRPDKCPLPPMAPETPPVPSSASSSSSSSSSPFKFKLQPPPLGRRQRAAGEKAPGGTDKSSGGSGSGGLAEGAGAVAPPPPPPQIKVEPISEGESEEVEVTDISDEDEEDGEVFKTPRAPPAPPKPEPGEAPGVAQCMPLKLRFKRRWSEDCRLEGGGCLSGGPEDEGEDKKVRGDVGPGESGGPLTPRRVSSDLQHATAQLSLEHRDS", "length": 551 }, "evidence": [ { "id": "F1MET2", "url": "https://omabrowser.org/oma/group/F1MET2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MET2", "url": "https://www.uniprot.org/uniprotkb/F1MET2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MET2", "url": "https://www.uniprot.org/uniprotkb/F1MET2" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1MET2", "url": "https://www.uniprot.org/uniprotkb/F1MET2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MET2", "url": "https://www.uniprot.org/uniprotkb/F1MET2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MET2", "url": "https://www.uniprot.org/uniprotkb/F1MET2" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MET2", "url": "https://www.uniprot.org/uniprotkb/F1MET2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "F1MET2", "url": "https://www.uniprot.org/uniprotkb/F1MET2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1MET2", "url": "https://www.uniprot.org/uniprotkb/F1MET2" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "F1MET2", "url": "https://www.uniprot.org/uniprotkb/F1MET2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MET2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 552, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MET2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MET2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MET2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MET2" }, { "id": "PS50061", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50061" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ETS", "eco_id": "ECO_0000259", "start_pos": 27, "end_pos": 107, "start_aa": "Ile", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MEW7-1", "uniprot_ac": "F1MEW7", "uniprot_id": "F1MEW7_BOVIN", "mass": { "chemical_mass": 58308.0, "monoisotopic_mass": 58308.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Interferon regulatory factor 2-binding protein 1", "type": "recommended", "evidence": [ { "id": "F1MEW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEW7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MEW7", "url": "https://www.uniprot.org/uniprotkb/F1MEW7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/F1MEW7", "locus": {} } ], "crossref": [ { "id": "F1MEW7", "url": "https://alphafold.ebi.ac.uk/entry/F1MEW7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000154", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000154", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR022750", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022750", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044882", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044882", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057414", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057414", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058682", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058682", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FKEPPIP", "url": "https://omabrowser.org/oma/group/FKEPPIP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10816", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10816", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10816:SF17", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10816:SF17", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11261", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11261", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25454", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25454", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25457", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25457", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MEW7", "url": "https://www.uniprot.org/uniprotkb/F1MEW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEW7-1", "url": "https://www.uniprot.org/uniprotkb/F1MEW7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVVKCRGCVNFEGADRIELLIDAARQLKHSHVLPEGRSPGPPALKHPATKDLAAAAAQGPQLRPPQAQPQPSGTGGAVSGQDRYDRATSSGRLPLPSPALEYTLGSRLANGLGREEAVAEGARRALLGSMPGLVLPGLLAAAVSALGSRGLTLAPGLSPARPAFGSDFEKEKQQRNADCLAELNEAMRGRAEERHGRPKAVREQLLALSACAPFNVRFKKDHGLVGRVFAFDATARPPGYEFELKLFTEYPCGSGNVYAGVLAVAHQMFHDALREPGKALASSGFKYLEYERRHGSGEWRQLGELLTDGVRSFRGPAPAEALPQQYPEPAPAALCGPPPRAPSRNLAPTPRRRKASPEPEGEAAGKMTTEEQQQRHWVAPGGPFPADTPGVPSPIAALKNVAEALGHSPKDPAGSGGPVRAGGASPTASSTAPPPAQHRLVARNGEAEVSPTAGAEAVSGGGSGARATPGAPLCCTLCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQGPAGEVYCPSGDKCPLVGSSVPWAFMQGEIATILAGDIKVKKERDP", "length": 556, "header": "tr|F1MEW7-1|F1MEW7_BOVIN Isoform 1 of Interferon regulatory factor 2-binding protein 1 OS=Bos taurus OX=9913 GN= PE=3 SV=3 CANONICAL=F1MEW7-1" }, "isoforms": [ { "isoform_ac": "F1MEW7-1", "url": "https://www.uniprot.org/uniprotkb/F1MEW7/entry", "sequence": { "sequence": "MVVKCRGCVNFEGADRIELLIDAARQLKHSHVLPEGRSPGPPALKHPATKDLAAAAAQGPQLRPPQAQPQPSGTGGAVSGQDRYDRATSSGRLPLPSPALEYTLGSRLANGLGREEAVAEGARRALLGSMPGLVLPGLLAAAVSALGSRGLTLAPGLSPARPAFGSDFEKEKQQRNADCLAELNEAMRGRAEERHGRPKAVREQLLALSACAPFNVRFKKDHGLVGRVFAFDATARPPGYEFELKLFTEYPCGSGNVYAGVLAVAHQMFHDALREPGKALASSGFKYLEYERRHGSGEWRQLGELLTDGVRSFRGPAPAEALPQQYPEPAPAALCGPPPRAPSRNLAPTPRRRKASPEPEGEAAGKMTTEEQQQRHWVAPGGPFPADTPGVPSPIAALKNVAEALGHSPKDPAGSGGPVRAGGASPTASSTAPPPAQHRLVARNGEAEVSPTAGAEAVSGGGSGARATPGAPLCCTLCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQGPAGEVYCPSGDKCPLVGSSVPWAFMQGEIATILAGDIKVKKERDP", "length": 556, "header": "tr|F1MEW7-1|F1MEW7_BOVIN Isoform 1 of Interferon regulatory factor 2-binding protein 1 OS=Bos taurus OX=9913 GN= PE=3 SV=3 CANONICAL=F1MEW7-1" }, "locus": { "chromosome": "X", "start_pos": 12117260, "end_pos": 12114840, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000177.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000177.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000177.6", "url": "https://www.ensembl.org/id/ENSBTAP00000000177.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 427, "start_aa": "Thr", "end_pos": 427, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr427", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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"MCLLMLQVTDPVNMNISEPDSHFVFVREFILLGFSYEWKIQSLLFSLFLTIYALTITGNGAIICALWCDQRLHIPMYVFLGNFSFLEIWYVSSTFPEMLVNFLSHKKTISFVGCFLQFYFFSSLGATECLHLTVMAFDRYLAICRPLHYPNIMTGHLCTKLVLICWVCGFLWFLVPIVLISQMPFCGPNIIDHVVCDPGPLFALACVSAPKTQLLCYSLSSIVIFGNFLFILGSYTLVLTAVLPMPSATGRQKAFSTCGSHLAVVSLFYGSLMVMYVSPGLGHSARMQKVTTLFYAMVTPFFNPLIYSLRNKEIKTALRKVLGSFNIM", "length": 328, "header": "tr|F1MEY7-1|F1MEY7_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR11H12B PE=3 SV=3 CANONICAL=F1MEY7-1" }, "isoforms": [ { "isoform_ac": "F1MEY7-1", "url": "https://www.uniprot.org/uniprotkb/F1MEY7/entry", "sequence": { "sequence": "MCLLMLQVTDPVNMNISEPDSHFVFVREFILLGFSYEWKIQSLLFSLFLTIYALTITGNGAIICALWCDQRLHIPMYVFLGNFSFLEIWYVSSTFPEMLVNFLSHKKTISFVGCFLQFYFFSSLGATECLHLTVMAFDRYLAICRPLHYPNIMTGHLCTKLVLICWVCGFLWFLVPIVLISQMPFCGPNIIDHVVCDPGPLFALACVSAPKTQLLCYSLSSIVIFGNFLFILGSYTLVLTAVLPMPSATGRQKAFSTCGSHLAVVSLFYGSLMVMYVSPGLGHSARMQKVTTLFYAMVTPFFNPLIYSLRNKEIKTALRKVLGSFNIM", "length": 328, "header": "tr|F1MEY7-1|F1MEY7_BOVIN Isoform 1 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"XP_005222482", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222482", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MF18", "url": "https://www.uniprot.org/uniprotkb/F1MF18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF18-1", "url": "https://www.uniprot.org/uniprotkb/F1MF18-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQLGEQLLVSSVNLPGAHFYPLEGARGGGGGSAGHLPGAAPSPQRLDLDKAPKKFSGSLSCEAASGEPAAAGAGAPATMLSDADAGDAFASAAAVAKPGPPDGRKGSPCGEEELPSAAAAAAAAAAASARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAPHGSVYPAPNGARYPYGSMLPPGGFPAAVCPPGRAQFGTGAGASGGAGGGGGGGGPGAYQYGQGAPLYGPYPAAAAAGTCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTASENDRLTPSPTDSPRSHQIVPGGRYGVQSFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPGTNKIDIGSYESEYSSSTLLPYGIKSLPLQTSHALGYYPDPGFPAMAGWGGRGSYQRKMAAGLPWTSRTSPPGFSEDQLSKEKVKEEIGSSWIETPPSIKSLDSNDSGVYTSACKRRRLSPSTSSNENSPSIKCEDINAEEYSKDSSKGMGGYYAFYTTP", "length": 701, "header": "tr|F1MF18-1|F1MF18_BOVIN Isoform 1 of Eomesodermin OS=Bos taurus OX=9913 GN=EOMES PE=4 SV=2 CANONICAL=F1MF18-1" }, "isoforms": [ { "isoform_ac": "F1MF18-1", "url": "https://www.uniprot.org/uniprotkb/F1MF18/entry", "sequence": { "sequence": "MQLGEQLLVSSVNLPGAHFYPLEGARGGGGGSAGHLPGAAPSPQRLDLDKAPKKFSGSLSCEAASGEPAAAGAGAPATMLSDADAGDAFASAAAVAKPGPPDGRKGSPCGEEELPSAAAAAAAAAAASARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAPHGSVYPAPNGARYPYGSMLPPGGFPAAVCPPGRAQFGTGAGASGGAGGGGGGGGPGAYQYGQGAPLYGPYPAAAAAGTCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTASENDRLTPSPTDSPRSHQIVPGGRYGVQSFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPGTNKIDIGSYESEYSSSTLLPYGIKSLPLQTSHALGYYPDPGFPAMAGWGGRGSYQRKMAAGLPWTSRTSPPGFSEDQLSKEKVKEEIGSSWIETPPSIKSLDSNDSGVYTSACKRRRLSPSTSSNENSPSIKCEDINAEEYSKDSSKGMGGYYAFYTTP", "length": 701, "header": "tr|F1MF18-1|F1MF18_BOVIN Isoform 1 of Eomesodermin OS=Bos taurus OX=9913 GN=EOMES PE=4 SV=2 CANONICAL=F1MF18-1" }, "locus": { "chromosome": "22", "start_pos": 2115756, "end_pos": 2110757, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061448.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061448.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053845.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053845.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 471, "start_aa": "Thr", "end_pos": 471, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr471", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D3ZY52-1", "protein_name": "Eomesodermin", "gene_name": "Eomes", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQLGEQLLVSSVNLPGAHFYSLESARGGGGGGGGGGGGGGGGSASLLPGAAPSPQRLDLDKASKKFPGSLPCQAGSAEPAGAGAGAPAAMLSDADAGDTFGSASAVAKPGPPDGRKGSPCAEEELPSAATAAATARYSMDSLSSERYYLPSPGPQGSELAAPCSLFQYPAAAGAAHGSVYPASNGARYPYGSMLPPGGFPAAVCPPARSQFGPATGSGSGAGSSGGGAGGPGGYPYGQGSPLYGPYAGTSAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTASENDRLTPSPTDSPRSHQIVPGGRYGVQNFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPVTNKLDIGSYESEYSSSTLLPYGIKSLPLQTSHALGYYPDPTFPAMAGWGGRGAYQRKMAAGLPWTSRMSPPVFPEDQLAKEKVKEEISSSWVETPPSIKSLDSNDSGVYNSACKRKRLSPTTSSNGNSPPIKCEDINTEEYSKDTSKGMGAYYAFYTTP", "length": 708 }, "evidence": [ { "id": "F1MF18", "url": "https://omabrowser.org/oma/group/F1MF18/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O54839-1", "protein_name": "Eomesodermin homolog", "gene_name": "Eomes", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQLGEQLLVSSVNLPGAHFYSLESARGGGGGGGGGGGGGGGSVSLLPGAAPSPQRLDLDKASKKFPGSLPCQAGSAEPAGAGAGAPAAMLSDADAGDTFGSTSAVAKPGPPDGRKGSPCAEEELPSAATAAATARYSMDSLSSERYYLPSPGPQGSELAAPCSLFQYPAAAGAAHGPVYPASNGARYPYGSMLPPGGFPAAVCPPARAQFGPAAGSGSGAGSSGGGAGGPGAYPYGQGSPLYGPYAGTSAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTASENDRLTPSPTDSPRSHQIVPGGRYGVQNFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPVTNKLDIGSYESEYTSSTLLPYGIKSLPLQTSHALGYYPDPTFPAMAGWGGRGAYQRKMAAGLPWTSRMSPPVFPEDQLAKEKVKEEISSSWIETPPSIKSLDSSDSGVYNSACKRKRLSPSTPSNGNSPPIKCEDINTEEYSKDTSKGMGAYYAFYTSP", "length": 707 }, "evidence": [ { "id": "F1MF18", "url": "https://omabrowser.org/oma/group/F1MF18/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O95936-1", "protein_name": "Eomesodermin homolog", "gene_name": "EOMES", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQLGEQLLVSSVNLPGAHFYPLESARGGSGGSAGHLPSAAPSPQKLDLDKASKKFSGSLSCEAVSGEPAAASAGAPAAMLSDTDAGDAFASAAAVAKPGPPDGRKGSPCGEEELPSAAAAAAAAAAAAAATARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAPHGPVYPAPNGARYPYGSMLPPGGFPAAVCPPGRAQFGPGAGAGSGAGGSSGGGGGPGTYQYSQGAPLYGPYPGAAAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSSHQIVPGGRYGVQSFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPGTNKLDISSYESEYTSSTLLPYGIKSLPLQTSHALGYYPDPTFPAMAGWGGRGSYQRKMAAGLPWTSRTSPTVFSEDQLSKEKVKEEIGSSWIETPPSIKSLDSNDSGVYTSACKRRRLSPSNSSNENSPSIKCEDINAEEYSKDTSKGMGGYYAFYTTP", "length": 686 }, "evidence": [ { "id": "F1MF18", "url": "https://omabrowser.org/oma/group/F1MF18/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GH67-1", "protein_name": "Eomesodermin", "gene_name": "EOMES", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQLGEPLLAAAGGALPGAPFYPLEGGGRGSGTGAGGGGGAASRGPPRPGSPAHLDLDKAAKKFAAAPAMLGEPDAGEPPFAAPKPDGRKTTPCGEEELPPAAAARYSMDSLSPERYYLQSPGPPVAELGGPCALFPYPPAAQHGAVYQAPGGPRYPYGSVLSSGGFAGAVCPPGGRTQFGGGGGYQYGQAAAGGALYGPYPPASGSCGGLGALGVPAAGPGLRAQVFLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNITGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKVYVHPESPNTGAHWMRQEISFGKLKLTNNKGANNNNAQMIVLQSLHKYQPRLHIVEVTEDGVEDLNDSSKTQTFIFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTASENDRLTPSPTDSPRSHQIVPGARYSVQPFFQEQFVNNLPPTRFYNGERTVPQTNGLLSPQQSEEVASPPQRWFVTPVQQPSANKLDMNSYETEYSPSTLLPYGIKSLPLQTSHALGYYPDPTFPSMAGWGSRGSYQRKMTTGLPWSSRTSPPGFSEDQLSKEKVKEEIGSSWIETPPSIKSLDSNDSGVYTGACKRRRLSPSTSSNENSPSMKCEDINAEDYSKDTSKGMGYYAFYTSS", "length": 661 }, "evidence": [ { "id": "F1MF18", "url": "https://omabrowser.org/oma/group/F1MF18/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "endodermal cell fate specification", "id": "GO:0001714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001714", "evidence": [ { "database": "UniProtKB", "id": "F1MF18", "url": "https://www.uniprot.org/uniprotkb/F1MF18" } ], "pmid": "" }, { "name": "CD8-positive, alpha-beta T cell differentiation involved in immune response", "id": "GO:0002302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002302", "evidence": [ { "database": "UniProtKB", "id": "F1MF18", "url": "https://www.uniprot.org/uniprotkb/F1MF18" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MF18", "url": "https://www.uniprot.org/uniprotkb/F1MF18" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MF18", "url": "https://www.uniprot.org/uniprotkb/F1MF18" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "F1MF18", "url": "https://www.uniprot.org/uniprotkb/F1MF18" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "F1MF18", "url": "https://www.uniprot.org/uniprotkb/F1MF18" } ], "pmid": "" }, { "name": "mesoderm formation", "id": "GO:0001707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001707", "evidence": [ { "database": "UniProtKB", "id": "F1MF18", "url": "https://www.uniprot.org/uniprotkb/F1MF18" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MF18", "url": "https://www.uniprot.org/uniprotkb/F1MF18" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1MF18", "url": "https://www.uniprot.org/uniprotkb/F1MF18" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1MF18", "url": "https://www.uniprot.org/uniprotkb/F1MF18" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1MF18", "url": "https://www.uniprot.org/uniprotkb/F1MF18" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 379, "end_pos": 381, "annotation": "n_glycosylation_sequon" }, { "start_pos": 646, "end_pos": 648, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MF18-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 701, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MF18-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MF18" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MF18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF18" }, { "id": "PS50252", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50252" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "T-box", "eco_id": "ECO_0000259", "start_pos": 267, "end_pos": 452, "start_aa": "Leu", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 471 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 379, "end_pos": 381 }, { "start_pos": 646, "end_pos": 648 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MF36-1", "uniprot_ac": "F1MF36", "uniprot_id": "F1MF36_BOVIN", "mass": { "chemical_mass": 107588.0, "monoisotopic_mass": 107588.0 }, "refseq": {}, "gene_names": [ { "name": "KSR2", "type": "recommended", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ], "protein_names": [ { "name": "non-specific serine/threonine protein kinase", "type": "recommended", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KSR2", "url": "https://www.uniprot.org/uniprotkb/F1MF36", "locus": { "chromosome": "17", "start_pos": 57665912, "end_pos": 57231546, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044119", "url": "https://www.ensembl.org/id/ENSBTAG00000044119" } ] } } ], "crossref": [ { "id": "F1MF36", "url": "https://alphafold.ebi.ac.uk/entry/F1MF36", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044119", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044119", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14153", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14153", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20873", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20873", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617325", "url": "https://www.ncbi.nlm.nih.gov/gene/617325", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046349", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046349", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046861", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046861", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046933", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046933", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050167", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050167", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:617325", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617325", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DSWDRPH", "url": "https://omabrowser.org/oma/group/DSWDRPH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MF36", "url": "https://www.orthodb.org/?gene=F1MF36", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23257", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23257", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23257:SF775", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23257:SF775", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07714", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13543", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13543", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20406", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20406", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5674135", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0ABI0P4F4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4F4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P4F4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4F4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF36-1", "url": "https://www.uniprot.org/uniprotkb/F1MF36-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEITPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVQSKCVQHYCHASPTLGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRRKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHSEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNLSLPASHYYKYRQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEGHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRRDDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL", "length": 950, "header": "tr|F1MF36-1|F1MF36_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=KSR2 PE=3 SV=3 CANONICAL=F1MF36-1" }, "isoforms": [ { "isoform_ac": "A0ABI0P4F4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4F4/entry", "sequence": { "sequence": "MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEITPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVQSKCVQHYCHASPTLGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRRKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHSEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNLSLPASHYYKYRQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEGHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRRDDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAE", "length": 949, "header": "tr|A0ABI0P4F4-1|A0ABI0P4F4_BOVIN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=KSR2 PE=3 SV=1 CANONICAL=F1MF36-1" }, "locus": { "chromosome": "17", "start_pos": 57662036, "end_pos": 57231745, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000141311.1", "url": "https://www.ensembl.org/id/ENSBTAT00000141311.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106292.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106292.1" } ] } }, { "isoform_ac": "F1MF36-1", "url": "https://www.uniprot.org/uniprotkb/F1MF36/entry", "sequence": { "sequence": "MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEITPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVQSKCVQHYCHASPTLGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRRKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHSEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNLSLPASHYYKYRQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEGHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRRDDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL", "length": 950, "header": "tr|F1MF36-1|F1MF36_BOVIN Isoform 1 of non-specific serine/threonine protein kinase OS=Bos taurus OX=9913 GN=KSR2 PE=3 SV=3 CANONICAL=F1MF36-1" }, "locus": { "chromosome": "17", "start_pos": 57664908, "end_pos": 57231745, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061442.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061442.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053828.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053828.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 188, "start_aa": "Thr", "end_pos": 188, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr188", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 528, "start_aa": "Thr", "end_pos": 528, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr528", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 541, "start_aa": "Thr", "end_pos": 541, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr541", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:617325", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617325", "resource": "KEGG Pathway" }, { "id": "R-BTA-5674135", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5674135", "resource": "Reactome", "description": "MAP2K and MAPK activation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PX90-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "KSR2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDEENMTRSEEQQQLSLQKALQQCELVQNMIDISISNLEGLRTKCAASNDLTQKEIRTLESKLVKYFSRQLSCKRKVALQERNAKLEGFPQLLHWFRIVDIRKEVMEEIAPGQLSLEELLEMTDDQVCETVEKFGANSEECARLNASLSCLRSVHKSGGSLSKQDWTIQWPTTEPGKENQPGCPPEPTPWSRTHLSASPKPPAKCAQHHCHGPLYTHVDRLTVEGHPGLCPPVESGHRSLPPSPRQRHAAHTPPRTPNIVTTMTPPGTPPLRRRNKLKPPGTPPPASRKLIHLLPGFTALHRSKSHEFQLGHRVDEAHTPKTKKKNKPLNLKIHNSVGSCENIPAQRSPLLSERSLRSFFVGYPPFLPSTPPVHTEATFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGGRRAVRGEADLHCKPLPPTLPLPPFLFRFPTARARLVRTESVPCDINNPLRKPPRYSDLHVSQTLPKTNKLNKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCPRQQKQFNLPASHYYKYKQQFIFPDVVPETPTRAPQVVLHPVTSNPILEGNPLLQIEVEPTSENEEGTEEAQESEDDFEEMNLSLLSARNFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVFHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRRENKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQVGRGMKPNLSQIGMGKEISDILLFCWAYEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL", "length": 970 }, "evidence": [ { "id": "F1MF36", "url": "https://omabrowser.org/oma/group/F1MF36/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8D1S1D9-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "KSR2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEITPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVQSKCIQHYCHASPTPGTPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRRKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEVNFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYRQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEGHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEEQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRRDDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL", "length": 950 }, "evidence": [ { "id": "F1MF36", "url": "https://omabrowser.org/oma/group/F1MF36/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8M3B9D7-1", "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "ksr2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDEENMTKSEEHHLSLQKALQQCELVQNMIDISISSLEGLRTKCATSNDLTQKEIRTLEGKLVKYFSRQLSYKRKVSLQERNAELDGFPRLGHWFRIVNMRKEVLEEISPGELTLEALLEMVDDQVCEELKKFGASDEECARLNASLSCLRSAHQSEQLEDDKLHSNGGSKQDWSIQWPTSESGKENTPVGPSDHSQWVRLQLSQSPKLHSRYSQHLCQSPQALVPPFYSPHPHSDRLTVDAHFPSPLETGHHSLPPSPRQRHFAHTPPRTPLVVNTMTPPGTPQVRRRNKLKAPGTPPPASRKLIHLLPGFTALHRSKSHEFQLGNRIDDAQTPKAKKKNKPLNLKIHSSVAGSCENLPTQRSPLHSDHSLRSFFFPNFVPSTPPVHSDTPSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCIVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIYHRGGREPFRDQVTSQGKEEARQLVRTESVPCDINNPLRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQSARQQKQSNLTASHFYKYKQQFIFPDVAPEVPTRAPQVILHPVLSEPGPKGSPLLQIEVEPTSDNEEGNDEAEGSADEFEEMNLSLLSARNFPRKASQTSIFLQEWDIPMEQVEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEEQLKAFKREVMAYRNTRHENVVLFMGACMRPPHLAIITSLCKGRTLYSVVRDAKVVLDVNKTRQIAQEMVKGMGYLHAKGILHKDMKSKNVFYDNGKVVITDFGLFTISGVLQAGSRRKDKLRIPSGWLCHLAPELIRQLSPETAENQLPFSKQSDVFAFGTIWYELHAREWPFKNQPAEVIIWQVGSGMKPILTQIGMGKEISDILLFCWAYEQEERPSFSKLMELLEKLPKRNRRLSHPVHFWKSAEYVK", "length": 966 }, "evidence": [ { "id": "F1MF36", "url": "https://omabrowser.org/oma/group/F1MF36/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q24171-1", "protein_name": "2.7.11.1", "gene_name": "ksr", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSSNNNAPASAPDTGSTNANDPISGSLSVDSNLVIIQDMIDLSANHLEGLRTQCAISSTLTQQEIRCLESKLVRYFSELLLAKMRLNERIPANGLVPHTTGNELRQWLRVVGLSQGTLTACLARLTTLEQSLRLSDEEIRQLLADSPSQREEEELRRLTRAMQNLRKCMESLESGTAASNNDPEQWHWDSWDRPTHIHRGSVGNIGLGNNSTASPRTHHRQHGVKGKNSALANSTNFKSGRQSPSATEELNSTQGSQLTLTLTPSPPNSPFTPSSGLSSSLNGTPQRSRGTPPPARKHQTLLSQSHVQVDGEQLARNRLPTDPSPDSHSSTSSDIFVDPNTNASSGGSSSNVLMVPCSPGVGHVGMGHAIKHRFTKALGFMATCTLCQKQVFHRWMKCTDCKYICHKSCAPHVPPSCGLPREYVDEFRHIKEQGGYASLPHVHGAAKGSPLVKKSTLGKPLHQQHGDSSSPSSSCTSSTPSSPALFQQRERELDQAGSSSSANLLPTPSLGKHQPSQFNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATANGGLDSLVSSSNGHMSSLIGSQTSNASTAATLTGSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFTSEYTDTHKSNDSDKTVSLSGSASTDSDRTPVRVDSTEDGDSGQWRQNSISLKEWDIPYGDLLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKVIITDFGLFSSTKLLYCDMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKKRLARSPSHPVNLSRSAESVF", "length": 966 }, "evidence": [ { "id": "F1MF36", "url": "https://omabrowser.org/oma/group/F1MF36/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q3UVC0-1", "protein_name": "Kinase suppressor of Ras 2", "gene_name": "Ksr2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCAASNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPDQLSLEDLLEMTDEQVCETVEKYGANQEECARLNASLSCLRNVHKSGGNLSKQDWIIQWPTTEPGQESNPVCPPEPSPWIRTHLSQSPRVQTKCPQHFCPTSPTPGTPVYTQVDRLTVDAYPNLCPPPPPLESGHRSLPPSPRQRHVVRTPPRTPNIVTTVTPPGTPPMRRKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGNRVDEANTPKAKKKSKPLNLKIHSGVGSCENIPAQQRSPLLSERSLRSFFVGHGPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDINNPVRKPARYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCPRQKKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNTILEGNPLLQIEVEPTSENEESHNEAEESEDEFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRRDDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL", "length": 951 }, "evidence": [ { "id": "F1MF36", "url": "https://omabrowser.org/oma/group/F1MF36/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6VAB6-1", "protein_name": "Kinase suppressor of Ras 2", "gene_name": "KSR2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL", "length": 950 }, "evidence": [ { "id": "F1MF36", "url": "https://omabrowser.org/oma/group/F1MF36/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ], "pmid": "" }, { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ], "pmid": "" }, { "name": "mitogen-activated protein kinase kinase binding", "id": "GO:0031434", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031434", "evidence": [ { "database": "UniProtKB", "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ], "pmid": "" }, { "name": "MAP-kinase scaffold activity", "id": "GO:0005078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005078", "evidence": [ { "database": "UniProtKB", "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "calcium-mediated signaling", "id": "GO:0019722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019722", "evidence": [ { "database": "UniProtKB", "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ], "pmid": "" }, { "name": "Ras protein signal transduction", "id": "GO:0007265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "database": "UniProtKB", "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ], "pmid": "" }, { "name": "positive regulation of cold-induced thermogenesis", "id": "GO:0120162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120162", "evidence": [ { "database": "UniProtKB", "id": "F1MF36", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 145, "end_pos": 147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 558, "end_pos": 560, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 636, "end_pos": 638, "annotation": "n_glycosylation_sequon" }, { "start_pos": 761, "end_pos": 763, "annotation": "n_glycosylation_sequon" }, { "start_pos": 893, "end_pos": 895, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", 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"F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "R-BTA-5672972", "name": "MAP2Ks and MAPKs bind to the activated RAF complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63258-1", "A0A3Q1LMP2-1", "Q0VBZ0-1", "P46196-1", "P60712-1", "P61223-1", "P62833-1", "F1MAZ8-1", "F1MF36-1", "E1B8P9-1", "E1BIM8-1", "A0A3Q1LQP3-1", "A0AAA9T2F0-1" ], "evidence": [ { "id": "R-BTA-5672972", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5672972" } ] }, { "id": "R-BTA-5672973", "name": "MAP2Ks phosphorylate MAPKs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63258-1", "A0A3Q1LMP2-1", "Q0VBZ0-1", "P46196-1", "P60712-1", "P61223-1", "P62833-1", "F1MAZ8-1", "F1MF36-1", "E1B8P9-1", "E1BIM8-1", "A0A3Q1LQP3-1", "A0AAA9T2F0-1" ], "evidence": [ { "id": "R-BTA-5672973", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5672973" } ] }, { "id": "R-BTA-5672978", "name": "RAF phosphorylates MAP2K dimer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63258-1", "A0A3Q1LMP2-1", "Q0VBZ0-1", "P46196-1", "P60712-1", "P61223-1", "P62833-1", "F1MAZ8-1", "F1MF36-1", "E1B8P9-1", "E1BIM8-1", "A0A3Q1LQP3-1", "A0AAA9T2F0-1" ], "evidence": [ { "id": "R-BTA-5672978", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5672978" } ] }, { "id": "R-BTA-5672980", "name": "Dissociation of RAS:RAF complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63258-1", "A0A3Q1LMP2-1", "Q0VBZ0-1", "P46196-1", "P60712-1", "P61223-1", "P62833-1", "F1MAZ8-1", "F1MF36-1", "E1B8P9-1", "E1BIM8-1", "A0A3Q1LQP3-1", "A0AAA9T2F0-1" ], "evidence": [ { "id": "R-BTA-5672980", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5672980" } ] }, { "id": "R-BTA-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63258-1", "A0A3Q1LMP2-1", "Q0VBZ0-1", "P46196-1", "P60712-1", "P61223-1", "P62833-1", "F1MAZ8-1", "F1MF36-1", "E1B8P9-1", "E1BIM8-1", "A0A3Q1LQP3-1", "A0AAA9T2F0-1" ], "evidence": [ { "id": "R-BTA-9657599", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9657599" } ] }, { "id": "R-BTA-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63258-1", "A0A3Q1LMP2-1", "Q0VBZ0-1", "P46196-1", "P60712-1", "P61223-1", "P62833-1", "F1MAZ8-1", "F1MF36-1", "E1B8P9-1", "E1BIM8-1", "A0A3Q1LQP3-1", "A0AAA9T2F0-1" ], "evidence": [ { "id": "R-BTA-9657603", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9657603" } ] }, { "id": "R-BTA-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63258-1", "A0A3Q1LMP2-1", "Q0VBZ0-1", "P46196-1", "P60712-1", "P61223-1", "P62833-1", "F1MAZ8-1", "F1MF36-1", "E1B8P9-1", "E1BIM8-1", "A0A3Q1LQP3-1", "A0AAA9T2F0-1" ], "evidence": [ { "id": "R-BTA-9657606", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9657606" } ] }, { "id": "R-BTA-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63258-1", "A0A3Q1LMP2-1", "Q0VBZ0-1", "P46196-1", "P60712-1", "P61223-1", "P62833-1", "F1MAZ8-1", "F1MF36-1", "E1B8P9-1", "E1BIM8-1", "A0A3Q1LQP3-1", "A0AAA9T2F0-1" ], "evidence": [ { "id": "R-BTA-9657608", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9657608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LMP2", "gene_name": "KRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A3Q1LMP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMP2" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] } ] }, { "uniprot_ac": "A0A3Q1LU59", "gene_name": "MAPK15", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LU59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LU59" } ] } ] }, { "uniprot_ac": "A0A3Q1LW88", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LW88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW88" } ] } ] }, { "uniprot_ac": "A0A3Q1LWT7", "gene_name": "CAMKK2", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1LWT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT7" } ] } ] }, { "uniprot_ac": "A0A3Q1LYH3", "gene_name": "RPS6KA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYH3" } ] } ] }, { "uniprot_ac": "A0A3Q1M1Z0", "gene_name": "ULK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M1Z0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M1Z0" } ] } ] }, { "uniprot_ac": "A0A3Q1M2U5", "gene_name": "VRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M2U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2U5" } ] } ] }, { "uniprot_ac": "A0A3Q1M334", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M614" } ] } ] }, { "uniprot_ac": "A0A3Q1M6N5", "gene_name": "BMP2K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M6N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6N5" } ] } ] }, { "uniprot_ac": "A0A3Q1M9F0", "gene_name": "MAST3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9F0" } ] } ] }, { "uniprot_ac": "A0A3Q1M9L7", "gene_name": "MAP4K5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M9L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M9L7" } ] } ] }, { "uniprot_ac": "A0A3Q1MA37", "gene_name": "CDC42BPG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MA37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA37" } ] } ] }, { "uniprot_ac": "A0A3Q1MD82", "gene_name": "CDK16", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1MD82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD82" } ] } ] }, { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MHH5", "gene_name": "MAP3K9", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1MHH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHH5" } ] } ] }, { "uniprot_ac": "A0A3Q1MHL3", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHL3" } ] } ] }, { "uniprot_ac": "A0A3Q1MHM3", "gene_name": "HIPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MHM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MHM3" } ] } ] }, { 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"https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { 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}, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { 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"https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BIM8", "gene_name": "SRC", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BIM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIM8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BIM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIM8" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P61223", "gene_name": "RAP1B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61223", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61223" } ] } ] }, { "uniprot_ac": "P62833", "gene_name": "RAP1A", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P62833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62833" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VBZ0", "gene_name": "CSK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.4", "activity": "ATP + [a protein]-(L-tyrosine) = ADP + [a protein]-(L-tyrosine)-phosphate. The optimal peptide substrate contains the sequence (relative to the phosphorylated tyrosine): Glu-Glu-Asp/Glu-Ile-Tyr-Phe-Phe-Phe-Phe. Physiological substrates are C-terminal tail of Src-family protein kinases.", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] }, { "ec_number": "2.7.10.4", "activity": "", "evidence": [ { "id": "Q0VBZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VBZ0" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": 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"Protein Classification" ] }, { "id": "PTHR48112", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48112", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48112:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48112:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00505", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00505", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09011", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09011", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MF42", "url": "https://www.uniprot.org/uniprotkb/F1MF42", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF42-1", "url": "https://www.uniprot.org/uniprotkb/F1MF42-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "CCTMWPKKRKEKIHKINTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE", "length": 205, "header": "tr|F1MF42-1|F1MF42_BOVIN Isoform 1 of High mobility group protein B2 OS=Bos taurus OX=9913 GN= PE=3 SV=4 CANONICAL=F1MF42-1" }, "isoforms": [ { "isoform_ac": "F1MF42-1", "url": "https://www.uniprot.org/uniprotkb/F1MF42/entry", "sequence": { "sequence": "CCTMWPKKRKEKIHKINTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE", "length": 205, "header": "tr|F1MF42-1|F1MF42_BOVIN Isoform 1 of High mobility group protein B2 OS=Bos taurus OX=9913 GN= PE=3 SV=4 CANONICAL=F1MF42-1" }, "locus": { "chromosome": "4", "start_pos": 14117043, "end_pos": 14115683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027565.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027565.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027565.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027565.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding, bending", "id": "GO:0008301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008301", "evidence": [ { "database": "UniProtKB", "id": "F1MF42", "url": "https://www.uniprot.org/uniprotkb/F1MF42" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MF42", "url": "https://www.uniprot.org/uniprotkb/F1MF42" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MF42", "url": "https://www.uniprot.org/uniprotkb/F1MF42" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MF42", "url": "https://www.uniprot.org/uniprotkb/F1MF42" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "F1MF42", "url": "https://www.uniprot.org/uniprotkb/F1MF42" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA recombination", "id": "GO:0006310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006310", "evidence": [ { "database": "UniProtKB", "id": "F1MF42", "url": "https://www.uniprot.org/uniprotkb/F1MF42" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "F1MF42", "url": "https://www.uniprot.org/uniprotkb/F1MF42" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MF42", "url": "https://www.uniprot.org/uniprotkb/F1MF42" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "F1MF42", "url": "https://www.uniprot.org/uniprotkb/F1MF42" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "F1MF42", "url": "https://www.uniprot.org/uniprotkb/F1MF42" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MF42-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 205, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MF42-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MF42" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MF42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF42" }, { "id": "PS50118", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50118" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HMG box", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 75, "start_aa": "Cys", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MF57-1", "uniprot_ac": "F1MF57", "uniprot_id": "F1MF57_BOVIN", "mass": { "chemical_mass": 116447.0, "monoisotopic_mass": 116447.0 }, "refseq": { "ac": "NP_001178342", "name": "nebulette", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178342" }, "gene_names": [ { "name": "NEBL", "type": "recommended", "evidence": [ { "id": "F1MF57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF57" } ] }, { "name": "NEBL", "type": "synonym", "evidence": [ { "id": "NP_001178342", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178342" } ] } ], "protein_names": [ { "name": "Nebulette", "type": "synonym", "evidence": [ { "id": "F1MF57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF57/entry#names_and_taxonomy" } ] }, { "name": "nebulette", "type": "synonym", "evidence": [ { "id": "NP_001178342", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178342" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MF57", "url": "https://www.uniprot.org/uniprotkb/F1MF57" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NEBL", "url": "https://www.uniprot.org/uniprotkb/F1MF57", "locus": { "chromosome": "13", "start_pos": 22096824, "end_pos": 22214013, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013339", "url": "https://www.ensembl.org/id/ENSBTAG00000013339" } ] } } ], "crossref": [ { "id": "F1MF57", "url": "https://alphafold.ebi.ac.uk/entry/F1MF57", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013339", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013339", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09447", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09447", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11935", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11935", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517987", "url": "https://www.ncbi.nlm.nih.gov/gene/517987", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035631", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035631", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051759", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051759", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055297", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055297", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517987", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517987", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EXKEYKK", "url": "https://omabrowser.org/oma/group/EXKEYKK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MF57", "url": "https://www.orthodb.org/?gene=F1MF57", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11039", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11039", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11039:SF48", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11039:SF48", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46218", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46218", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46218:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46218:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00880", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00880", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178342", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0ABI0NSB4", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSB4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NSB4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSB4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NWM2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NWM2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWM2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P4X0", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4X0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P4X0-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P4X0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF57", "url": "https://www.uniprot.org/uniprotkb/F1MF57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MF57-1", "url": "https://www.uniprot.org/uniprotkb/F1MF57-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRVPVFEDVKDETEEEKTGEEENEEDKVFFKPVIEDLSMELARRCTELISDIHYKEEYKKSKGKCMFVTDTPMLNHVKHIGAFISEAKYKGTIKADLSNSLYKQMPATIDSVFAREVTQLQSEIAYRQKHDAAKGVSDYAHMKEPPEIKHAMEVNKHQSNIFYRKDVQDTHMYNAELDRPDIKMATQISKIISDAEYKKGQGVMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDSEMKDKKHLYNPLESASFRQSQLATALASNVKYKKDIQNMHDPVSGLPNLFLDHALKVSKMLSGREYRKVFEENKGLYHFDVDAAEHLHHKGNAMLQSQVKYKEEYEKNKGKSMLEFVETPSYQVSKEAQKMQSEKVYREDFEKDIKGRSSMDLDKTPEFLHVKYITNLLKEKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMTSEKEYKKDLESEIKGKGMQVGTDTLGIQHAKRASEMASEKDYKRDLETEIRGKGMQVSTDTLDIQRAKKASEMASQKEYKKDLENEIKGKGMQVSMDIPDMLRAKRASEIYSQKKYKDEAEKMLSSYSTVADTPEIQRIKTTQQNISAVFYKKEVGAGTAVKDTPEIERVKKNQQNISSVKYKEEVKHATAISDPPELKRVKENQKNISNLRYKEPCDRATPVSMTPEIERVRRNQEQLSTVKYRGEIKQATAISDPPELKRVKENQKNLSNVYYKSQMGRATALSVTPEMERVKKNQENISSVKYTQDQKQMKGRPSLILDTPGLRHVKEAQNRISMVKYHEDFEKTKGRGFTPVVDDPVTERVRRNTQVVSDAAYKGVHPHIVEMDRRPGIIVDLKVWRTDPGSIFDIDPLEDNIQSRSLHMLSEKANLYRRQRSRSYSSSTFGTGLGDDKSEISEIYRSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSLSSVRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGKTGMLPANYIEFVN", "length": 1013, "header": "tr|F1MF57-1|F1MF57_BOVIN Isoform 1 of Nebulette OS=Bos taurus OX=9913 GN=NEBL PE=4 SV=3 CANONICAL=F1MF57-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NSB4-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSB4/entry", "sequence": { "sequence": "SQRDQETCPKAHRRGKSQVRTQAAWLQRSHEPWALGKKHYPKQSFTTVADTPENLRLKQQSELQSQVKYKRDFEESKGRGFSIVTDTPELQRLKRTQEQISNVKYHEDFEKTKGRGFTPVVDDPVTERVRRNTQVVSDAAYKGVHPHIVEMDRRPGIIVAPVLPGAYQQSHSQGYGYMHQTSLSSVRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGKTGMLPANYIEFVN", "length": 253, "header": "tr|A0ABI0NSB4-1|A0ABI0NSB4_BOVIN Computationally mapped isoform of Nebulette OS=Bos taurus OX=9913 GN=NEBL PE=4 SV=1 CANONICAL=F1MF57-1" }, "locus": { "chromosome": "13", "start_pos": 22339205, "end_pos": 22100374, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000143702.1", "url": "https://www.ensembl.org/id/ENSBTAT00000143702.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105803.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105803.1" } ] } }, { "isoform_ac": "A0ABI0NWM2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWM2/entry", "sequence": { "sequence": "MFSSLPGLCLLDAYEELEAREIKKPAQRHTGGEKARHYPKQSFTTVADTPENLRLKQQSELQSQVKYKRDFEESKGRGFSIVTDTPELQRLKRTQEQISNVKYHEDFEKTKGRGFTPVVDDPVTERVRRNTQVVSDAAYKGVHPHIVEMDRRPGIIVAPVLPGAYQQSHSQGYGYMHQTSLSSVRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGKTGMLPANYIEFVN", "length": 251, "header": "tr|A0ABI0NWM2-1|A0ABI0NWM2_BOVIN Computationally mapped isoform of Nebulette OS=Bos taurus OX=9913 GN=NEBL PE=4 SV=1 CANONICAL=F1MF57-1" }, "locus": { "chromosome": "13", "start_pos": 22339709, "end_pos": 22100374, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138854.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138854.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104227.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104227.1" } ] } }, { "isoform_ac": "A0ABI0P4X0-1", "url": 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[ { "database": "UniProtKB", "id": "F1MF57", "url": "https://www.uniprot.org/uniprotkb/F1MF57" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 588, "end_pos": 590, "annotation": "n_glycosylation_sequon" }, { "start_pos": 619, "end_pos": 621, "annotation": "n_glycosylation_sequon" }, { "start_pos": 650, "end_pos": 652, "annotation": "n_glycosylation_sequon" }, { "start_pos": 712, "end_pos": 714, "annotation": "n_glycosylation_sequon" }, { "start_pos": 743, "end_pos": 745, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MF57-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1013, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MF57-F1.pdb", "url_external": 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"database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLLLLVAIPLLVHSSQGPAHYEMLGRCRMVCDPHGPRGPGPDGAPASVPPFPPGAKGEAGRRGKAGLRGPPGPPGPRGPPGEPGRPGPPGPPGPGPGGVAPPAGYVPRIAFYAGLRRPHEGYEVLRFDDVVTNVGNAYEAASGKFTCPMPGVYFFAYHVLMRGGDGTSMWADLMKNGQVRASAIAQDADQNYDYASNSVILHLDVGDEVFIKLDGGKVHGGNTNKYSTFSGFIIYPD", "length": 238, "header": "tr|F1MFA0-1|F1MFA0_BOVIN Isoform 1 of Complement C1q like 4 OS=Bos taurus OX=9913 GN=C1QL4 PE=4 SV=2 CANONICAL=F1MFA0-1" }, "isoforms": [ { "isoform_ac": "F1MFA0-1", "url": "https://www.uniprot.org/uniprotkb/F1MFA0/entry", "sequence": { "sequence": "MVLLLLVAIPLLVHSSQGPAHYEMLGRCRMVCDPHGPRGPGPDGAPASVPPFPPGAKGEAGRRGKAGLRGPPGPPGPRGPPGEPGRPGPPGPPGPGPGGVAPPAGYVPRIAFYAGLRRPHEGYEVLRFDDVVTNVGNAYEAASGKFTCPMPGVYFFAYHVLMRGGDGTSMWADLMKNGQVRASAIAQDADQNYDYASNSVILHLDVGDEVFIKLDGGKVHGGNTNKYSTFSGFIIYPD", "length": 238, "header": "tr|F1MFA0-1|F1MFA0_BOVIN Isoform 1 of Complement C1q like 4 OS=Bos taurus OX=9913 GN=C1QL4 PE=4 SV=2 CANONICAL=F1MFA0-1" }, 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"sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MFA9-1", "uniprot_ac": "F1MFA9", "uniprot_id": "F1MFA9_BOVIN", "mass": { "chemical_mass": 90423.0, "monoisotopic_mass": 90423.0 }, "refseq": {}, "gene_names": [ { "name": "MCPH1", "type": "recommended", "evidence": [ { "id": "F1MFA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFA9" } ] } ], "protein_names": [ { "name": "Microcephalin", "type": "recommended", "evidence": [ { "id": "F1MFA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFA9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Implicated in chromosome condensation and DNA damage induced cellular responses. 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"tr|F1MFA9-1|F1MFA9_BOVIN Isoform 1 of Microcephalin OS=Bos taurus OX=9913 GN=MCPH1 PE=4 SV=4 CANONICAL=F1MFA9-1" }, "locus": { "chromosome": "27", "start_pos": 5685936, "end_pos": 5446177, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031604.7", "url": "https://www.ensembl.org/id/ENSBTAT00000031604.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031555.6", "url": "https://www.ensembl.org/id/ENSBTAP00000031555.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2299718", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2299718", "resource": "Reactome", "description": "Condensation of Prophase Chromosomes" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": 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"https://www.uniprot.org/uniprotkb/F1MFC1" } ], "pmid": "" }, { "name": "phospholipase A2 activity", "id": "GO:0004623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004623", "evidence": [ { "database": "UniProtKB", "id": "F1MFC1", "url": "https://www.uniprot.org/uniprotkb/F1MFC1" } ], "pmid": "" }, { "name": "phosphatidylinositol-5-phosphate binding", "id": "GO:0010314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010314", "evidence": [ { "database": "UniProtKB", "id": "F1MFC1", "url": "https://www.uniprot.org/uniprotkb/F1MFC1" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "F1MFC1", "url": "https://www.uniprot.org/uniprotkb/F1MFC1" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4,5-trisphosphate binding", "id": "GO:0005547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005547", "evidence": [ { "database": "UniProtKB", "id": "F1MFC1", "url": "https://www.uniprot.org/uniprotkb/F1MFC1" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4-bisphosphate binding", "id": "GO:0043325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043325", "evidence": [ { "database": "UniProtKB", "id": "F1MFC1", "url": "https://www.uniprot.org/uniprotkb/F1MFC1" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,5-bisphosphate binding", "id": "GO:0080025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080025", "evidence": [ { "database": "UniProtKB", "id": "F1MFC1", "url": "https://www.uniprot.org/uniprotkb/F1MFC1" } ], "pmid": "" }, { "name": "calcium-dependent phospholipid binding", "id": "GO:0005544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005544", "evidence": [ { "database": "UniProtKB", "id": "F1MFC1", "url": "https://www.uniprot.org/uniprotkb/F1MFC1" } ], "pmid": "" }, { "name": "phosphatidylinositol-4-phosphate binding", "id": "GO:0070273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070273", "evidence": [ { "database": "UniProtKB", "id": "F1MFC1", "url": "https://www.uniprot.org/uniprotkb/F1MFC1" } ], "pmid": "" }, { "name": "phosphatidylinositol-3-phosphate binding", "id": "GO:0032266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032266", "evidence": [ { "database": "UniProtKB", "id": "F1MFC1", "url": "https://www.uniprot.org/uniprotkb/F1MFC1" } ], "pmid": "" }, { "name": "N-acyltransferase activity", "id": "GO:0016410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016410", "evidence": [ { "database": "UniProtKB", "id": "F1MFC1", "url": "https://www.uniprot.org/uniprotkb/F1MFC1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" }, { "start_pos": 699, "end_pos": 701, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15177", "name": "", "equation": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T0P5-1", "Q8WMP9-1", "A4IFJ5-1", "A0A3Q1LV96-1", "Q3SZ79-1", "G3X6Z1-1", "F1MNU5-1", "E1BB89-1", "A0AAA9RYE9-1", "E1BC49-1", "F1MG30-1", "F1MGH2-1", "F1MFC1-1" ], "evidence": [ { "id": "15177", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15177" } ] }, { "id": "15801", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MFC1-1", "F1MG30-1", "E1BB89-1", "E1BC49-1", "Q8WMP9-1", "P00593-1", "A4IFJ5-1", "A0A3Q1LV96-1", "E1BLF3-1", "O77834-1", "E1B9V3-1", "E1BEG8-1", "A0AAA9T9W1-1", "Q56JZ2-1", "G3N3U6-1", "Q0VC00-1", "Q1JPB9-1", "Q2KI18-1", "A0A3Q1LNM7-1", "F1MNU5-1", "F1MSG5-1", "F6RTH3-1", "A0AAA9TQC6-1", "G5E5T0-1", "A0AAA9RYE9-1", "A0ABI0P1I9-1" ], "evidence": [ { "id": "15801", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15801" } ] }, { "id": "36231", "name": "", "equation": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "P79106-1", "A0A3Q1LV96-1", "F1MNU5-1", "E1BB89-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "36231", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36231" } ] }, { "id": "40427", "name": "", "equation": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BC49-1", "F1MFC1-1", "F1MG30-1", "A4IFJ5-1", "P00593-1", "Q1JPB9-1", "F1MNU5-1", "E1BB89-1", "A0AAA9RYE9-1" ], "evidence": [ { "id": "40427", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40427" } ] }, { "id": "40451", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "40451", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40451" } ] }, { "id": "40519", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BB89-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "40519", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40519" } ] }, { "id": "40811", "name": "", "equation": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "A0A3Q1LV96-1", "E1BLF3-1", "Q56JZ2-1", "Q1JPB9-1", "F1MNU5-1", "E1BB89-1", "A0AAA9RYE9-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "40811", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40811" } ] }, { "id": "41067", "name": "", "equation": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BB89-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41067", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41067" } ] }, { "id": "41071", "name": "", "equation": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41071", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41071" } ] }, { "id": "41075", "name": "", "equation": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41075", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41075" } ] }, { "id": "41087", "name": "", "equation": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41087", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41087" } ] }, { "id": "41099", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41099", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41099" } ] }, { "id": "41123", "name": "", "equation": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41123", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41123" } ] }, { "id": "41271", "name": "", "equation": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 2-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41271", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41271" } ] }, { "id": "41307", "name": "", "equation": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41307", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41307" } ] }, { "id": "53688", "name": "", "equation": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "53688", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53688" } ] }, { "id": "53692", "name": "", "equation": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O = prostaglandin E2 + sn-glycerol 3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "53692", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53692" } ] }, { "id": "53696", "name": "", "equation": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "53696", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53696" } ] }, { "id": "53700", "name": "", "equation": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "53700", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53700" } ] }, { "id": "53704", "name": "", "equation": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O = sn-glycero-3-phosphoethanolamine + prostaglandin E2 + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "53704", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53704" } ] }, { "id": "R-BTA-1482612", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-975614" ], "output_participant_list": [ "R-ALL-1498750" ], "enzyme_list": [ "Q9GL30-1", "F1MNU5-1", "F1MG30-1", "F1MFC1-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482612", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482612" } ] }, { "id": "R-BTA-1482685", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-1524028" ], "output_participant_list": [], "enzyme_list": [ "Q9GL30-1", "F1MNU5-1", "F1MG30-1", "F1MFC1-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482685", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482685" } ] }, { "id": "R-BTA-1482771", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[9]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MNU5-1", "F1MG30-1", "F1MFC1-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482771", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482771" } ] }, { "id": "R-BTA-1482828", "name": "PE is hydrolyzed to 2-acyl LPE by PLA2[4]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MNU5-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "R-BTA-1482828", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482828" } ] }, { "id": "R-BTA-1482862", "name": "PC is hydrolysed to 2-acyl LPC by PLA2[7]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MNU5-1", "F1MG30-1", "F1MFC1-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482862", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482862" } ] }, { "id": "R-BTA-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9GL30-1", "F1MNU5-1", "F1MG30-1", "F1MFC1-1", "E1BB89-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482884", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482884" } ] }, { "id": "R-BTA-1482932", "name": "PI is hydrolyzed to 2-acyl LPI by PLA2[13]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-1498737" ], "enzyme_list": [ "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "R-BTA-1482932", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482932" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1498737", "participant_name": "2-acyl LPI [endoplasmic reticulum membrane]", "crossref": [ { "id": "62746", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1498750", "participant_name": "GPCho [cytosol]", "crossref": [ { "id": "ZINC000001532714", "database": "ZINC", "url": "" }, { "id": "16870", "database": "ChEBI", "url": "" }, { "id": "HMDB0000086", "database": "HMDB Metabolite", "url": "" }, { "id": "C00670", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-1524028", "participant_name": "1-acyl LPC [endoplasmic reticulum membrane]", "crossref": [ { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-975614", "participant_name": "2-acyl LPC [endoplasmic reticulum membrane]", "crossref": [ { "id": "16728", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LNM7", "gene_name": "PLA2G2F", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LNM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNM7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A0A3Q1LNM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNM7" } ] } ] }, { "uniprot_ac": "A0A3Q1LV96", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "A0A3Q1LV96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV96" } ] } ] }, { "uniprot_ac": "A0AAA9RYE9", "gene_name": "PNPLA8", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9RYE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE9" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0AAA9RYE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYE9" } ] } ] }, { "uniprot_ac": "A0AAA9T0P5", "gene_name": "PNPLA6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9T0P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0P5" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0AAA9T0P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0P5" } ] } ] }, { "uniprot_ac": "A0AAA9T9W1", "gene_name": "PLA2G2C", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9T9W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9W1" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A0AAA9T9W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9W1" } ] } ] }, { "uniprot_ac": "A0AAA9TQC6", "gene_name": "LOC613966", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A0AAA9TQC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQC6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A0AAA9TQC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TQC6" } ] } ] }, { "uniprot_ac": "A0ABI0P1I9", "gene_name": "", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "A0ABI0P1I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1I9" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "A0ABI0P1I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1I9" } ] } ] }, { "uniprot_ac": "A4IFJ5", "gene_name": "PLA2G4A", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A4IFJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFJ5" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "A4IFJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFJ5" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "A4IFJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4IFJ5" } ] } ] }, { "uniprot_ac": "E1B9V3", "gene_name": "LOC112443425", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1B9V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9V3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1B9V3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9V3" } ] } ] }, { "uniprot_ac": "E1BB89", "gene_name": "PLA2G6", "activity": [ { "ec_number": "3.1.2.2", "activity": "hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "E1BB89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB89" } ] } ] }, { "uniprot_ac": "E1BC49", "gene_name": "PLA2G4B", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BC49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC49" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1BC49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC49" } ] } ] }, { "uniprot_ac": "E1BEG8", "gene_name": "PLA2G5", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BEG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEG8" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1BEG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEG8" } ] } ] }, { "uniprot_ac": "E1BLF3", "gene_name": "LOC615045", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "E1BLF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLF3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "E1BLF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLF3" } ] } ] }, { "uniprot_ac": "F1MFC1", "gene_name": "PLA2G4E", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", 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"length": 1064, "header": "tr|A0ABI0P3S2-1|A0ABI0P3S2_BOVIN Computationally mapped isoform of FERM, ARHGEF and pleckstrin domain-containing protein 1 OS=Bos taurus OX=9913 GN=FARP1 PE=4 SV=1 CANONICAL=F1MFC6-1" }, "locus": { "chromosome": "12", "start_pos": 75457343, "end_pos": 75219913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136444.1", "url": "https://www.ensembl.org/id/ENSBTAT00000136444.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107667.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107667.1" } ] } }, { "isoform_ac": "F1MFC6-1", "url": "https://www.uniprot.org/uniprotkb/F1MFC6/entry", "sequence": { "sequence": "MGEIEQRPTPGSRLGAPENSGISTLEHGQKPPPTPSGKLMSIKIQMLDDTQEAFEVPVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLACNDNSAALLISHIVQSEIGDFDEASDREHLAKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARKLEMYGVRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDVNSSYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLATQPSEPNSEVPKQAQQSVSLTLGEGSEPPGGQSCPQGGDLTAASAEDAERQRGPGPSRSPAGSAKGDGASGAAAEEDEELVKDRPQQSRPRPPQPSTGSLTGSPHLSELSINSQGGTAPTNAILSPNLSPDTKQASPLVSPLLNDQAGPRAEDEDDGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDSMPETLKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAHIRGDYQRIGDVMLKNIQGMKQLAAHLWKHSEALEALETGIRGSRRLESLCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHYPPSHSDFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVIPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTMEESEEEWGVPHCLTLRGQRQSIVVAASSRPEMDKWVEDIQMAIDLAEKSSGPAPEFLASSPPDNKSPEEAAGDQESEDDLSASRTSLERQAPHRGNTMVHVCWHRNTSVSMVDFSVAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASLPLLGYSLTIPSESEDIHKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRAHAPSHKESHVY", "length": 1011, "header": "tr|F1MFC6-1|F1MFC6_BOVIN Isoform 1 of FERM, ARHGEF and pleckstrin domain-containing protein 1 OS=Bos taurus OX=9913 GN=FARP1 PE=4 SV=4 CANONICAL=F1MFC6-1" }, "locus": { "chromosome": "12", "start_pos": 75457343, "end_pos": 75219913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000167.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000167.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000167.7", "url": "https://www.ensembl.org/id/ENSBTAP00000000167.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 34, "start_aa": "Thr", "end_pos": 34, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr34", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-BTA-9035034", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9035034", "resource": "Reactome", "description": "RHOF GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MFC6", "url": "https://www.uniprot.org/uniprotkb/F1MFC6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MFC6", "url": "https://www.uniprot.org/uniprotkb/F1MFC6" } ], "pmid": "" }, { "name": "dendritic spine", "id": "GO:0043197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "database": "UniProtKB", "id": "F1MFC6", "url": "https://www.uniprot.org/uniprotkb/F1MFC6" } ], "pmid": "" }, { "name": "filopodium", "id": "GO:0030175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030175", "evidence": [ { "database": "UniProtKB", "id": "F1MFC6", "url": "https://www.uniprot.org/uniprotkb/F1MFC6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "F1MFC6", "url": "https://www.uniprot.org/uniprotkb/F1MFC6" } ], "pmid": "" }, { "name": "cytoskeletal protein binding", "id": "GO:0008092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008092", "evidence": [ { "database": "UniProtKB", "id": "F1MFC6", "url": "https://www.uniprot.org/uniprotkb/F1MFC6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 250, "end_pos": 252, "annotation": "n_glycosylation_sequon" }, { "start_pos": 467, "end_pos": 469, "annotation": "n_glycosylation_sequon" }, { "start_pos": 843, "end_pos": 845, "annotation": "n_glycosylation_sequon" }, { "start_pos": 885, "end_pos": 887, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MFC6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1011, "overlap": "1.0", "method": "AlphaFold", "type": 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"MHKMSMQRLSLLLLLQLTCYFNSGSCGKVLVWPMEYSHWMNMKTILDELVTRGHEVTVLIPSVTTFIDPKKPSSLKLETFPPSLTKEESENFVKLFVEAWMHAVRDSFWNHLSMVQSLFWGYSDILMKMCKEVVSNKKLMTKLHEERFDVIFADAVGPCGELLAEILKIPFMYSLYSTPGSSVEKKSGRLPFPPSYVPAMFSELSDHMTFMERVKNMIYVLYFDFWFQAYNEKNWNQFYSEVLGRPTTLVETMGKAEMWLIRNYWDFSFPRPRLPNFEFVGGLHCKPAKSLPKEMEEFVQSSGENGIVVFSLGSMVSNMSKERANVIASALAQIPQKVLWRYDGKKPDTLGPNTQLYKWIPQNDLLGHPKTKAFVTHGGSNGIYEAIYHGIPIVGLPLFADQPHNIVHMKAKGAAVRLDLETMSTEDLLNALKEVINNPSYKENMMRLSAIHHDRPVKPLDLAVFWIEFVMRHKGAKHLRPAVHNLTWLQYHSLDVIGFLLACVATGAFVITKCCLFCYQKFAGKGKKGKRD", "length": 532, "header": "tr|F1MFF6-1|F1MFF6_BOVIN Isoform 1 of UDP-glucuronosyltransferase OS=Bos taurus OX=9913 GN=UGT2B10 PE=3 SV=3 CANONICAL=F1MFF6-1" }, "isoforms": [ { "isoform_ac": "F1MFF6-1", "url": "https://www.uniprot.org/uniprotkb/F1MFF6/entry", "sequence": { "sequence": 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"ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21032", "name": "", "equation": "glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T3U6-1", "G3N150-1", "F1MFF6-1", "F1MRL5-1", "E1BBB3-1", "E1BJU8-1", "A0AAA9S6P8-1", "A0A3Q1M7T0-1", "A0A3Q1MKS1-1", "A0A3Q1LYU5-1", "A0AAA9TS57-1" ], "evidence": [ { "id": "21032", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21032" } ] }, { "id": "R-BTA-158546", "name": "UGTs glucuronate APAP to APAP-GlcA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-158601" ], "output_participant_list": [ "R-ALL-158604" ], "enzyme_list": [ "E1BJU8-1", "A0A3Q1LYU5-1", "F1MFF6-1", "E1BBB3-1" ], "evidence": [ { "id": "R-BTA-158546", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-158546" } ] }, { "id": "R-BTA-9758661", "name": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF16184", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19309", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19309", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002691845", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691845", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MFH3", "url": "https://www.uniprot.org/uniprotkb/F1MFH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFH3-1", "url": "https://www.uniprot.org/uniprotkb/F1MFH3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQATGTPGVTARTRPAGNPTKSPPTPPTPSGLVLLLLLSLVSRVRAQPPDPGRALLSPDLAGVAGVPAEEAIVLANRGLRVPFGREVWLDPLQDLVLQVQPGDRCAVTVLDNDALAQRPGRLSPKRFPCDFGAGEVRYSHLGARSPSRDRVRLQLRYDAPGGAAVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFAYQPETQECRVGILPGLGALPRYGELLHYPQVPGSASEGDSQEPLLMDCTAFQELGVRYRHTAPSRSPNRDWVPMVVELRSRGSPVGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAECAPDLLIFNLTSPFQPGQGFLVSTDDRSLPLSSFTQRDLHLLKIAYQPPSEDSDQERLFELELEVVDPEGAASDPFSFMVVVKPMNTLAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEAVQLEVVAGLRHGHLVLLGASNGNSAPKTFTVAELAAGRVVYHHDDKDGSLSDNLVLLMVDGGRRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPQALSAIDMDSEDSLLLFVLESPSSTAGHLLLRQTHPPQGEEMLLGSPWRKQGIFYEKTVTQWRQRDITEGRLFYRHSGPHSPGPVIDQFTFRVQDNHDPPNKSGLQRFMIRIHPVDRLPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQPPMDTDENHSPAPLGTLVLTDDPSVVVAHFTQAQVNHHKIAYRPPDQELGVAARVAQFQFQVEDRAGNVAPGTFTFYLQPVDNQPPEILNTGFTVQEKGHHILSETELGVNDVDTDVAHITFTLIQVPKHGHMKLSGQVLHVGGIFHLEDIKQGRISYAHNGAESLTDSCSLEVSDRHHVVPITLRVNVRPMDGELPMLSLPAGTLGSYLDVLENRATEITANVIRGTNGDADDLMLTFLLEDPPLYGEILVNGVPAEQFTQRDILEGSVVYTHTSGEIGLLPKEDSFNLSLSDMSQEWRIGGNTIQGVTMWVTILPVDSQAPEISVGEQFIVLEGDKSAITSMHISAEDMDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAVSAFTLKDLRQGHINYVQSVHKGVEPVEDRFIFRCSDGINFSERHFFPIVIIPTNDEQPEIFIREFLVMEGMSLVVDTPILNAADADVPPDDLTFTITKFPTHGHIMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIQLTDGKHSVEKTVLIMVIPVDDETPRMAINNGLEIEIGETKIINNRILMATDLDSEDKFLVYIIRYGPGHGLLQRQTPTGVFENITLGMNFTQDEVDSNLIQYVHFGQEGIRDLIKFDVTDGINALIDRYFYVSIGSPDIVFPDVISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLESTDQPRVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHNLVVSEGEKKLITPFELTVEDRDTPDKLLKFTVTQVPVHGQLLFNNTRPAMIFTKQDLNENLISYRHDGTESSEDSFSFTVTDGSHTDFYVFPDTVFETRRPQVMKIRILAVDNRVPQIVVNKGASTLRTLATGHLGFMITSKVLKAEDRDSLHVSLRFIVTEAPRHGYLLNLGQGNHSVTEFTQADIDDMKICYVLREGANAVSDIFQFTVEDGGGNKLTKQHFRLNWAWISFEKEYYLINEDSKFLDVMLKRRGYLGETSFISIGTRDGTAKKDKDFKGKAQRQVQFNPGQTRATWRVRILSDGAHEQSETFQVVLAEPVLAALEFPAVTTVEIVDPGDESTVFIPQSEYSIEEDVGELFIPIRRSGDVSQELMVVCYTRQGTARGTVPTSVLSYSDYISRPEDHTSVIRFDKDEREKMCRVVIIDDSLFEEEETFHVLLSMPMGGRIGSEFPGAQVTIKPDKDDEPVFYFGDVEYKVDESAGSVEVRVWRSGTDLSQASSVTVTSQKTDPPSADAGTDYVGISRNLDFAPGVNMQTIRVIILDDLGQPMLEGIEQFELVLRMPMNAALGDPSKATVTINDSVSDLPKMQFKERVYTGNENDGQIVATIHRSGDTRYRSSVRCYTRQGSAQVMMDFEERPNTDISIITFLPGEIEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTIIKFGETKFSVSEPKEPGQSVVIKIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHIVEIEVIFDGVREMREAFTVHLKPDENMIAETQATKAIVYIEEMNSMADVTFPSVPQVVSLLTYDDSSRAKESAGPVSGYPVVCITACNPKYPDYEKTGSICASENINDTSTRYRWLISAPAGPDGVTSPMREVDFDTFFTSSKMITLDSIYFQPGSRVQCAARAVNADGSEGLELMSPIVTIGREEGLCQPRVPGIVGAEPFSAKLRYTGPEDSEYTNLIKLTVTMPHTDGMLPVISTKELSNFELTLSPDGTRVGNHKCSNLLDYTEVKTHHGFLTDATKNPEIIGETYPYQYSSSIRGSNTLRFYRNLNLEACLWEFVSYYDMSELLTDCGGTIGTDGQVLNLVQSYVTLRVPLYVSYVFHSPAGVGGWQHFDLKSELRLTFVYDTAILWTDGIGSPPEAELQGSLYPTSMRIGEEGRLVVNFKTEAQFHGLFVLSHPASFTSSMIMSVDHPGLTFSLRLIRSEPTYNQPVQQWSFVSDFAVRDYSGTYTVKLLPCTTPSHQEFRLPVTCNPREPITFDLDIRFQQVSDPVAAEFSLNTQMYLLSKKSLWLSDGSMGFGQESDVAFAEGDIIYGRVMVDPVQNLGDSFYCSIEKVFLCTGADGYVPKYNPTNAEYGCLADSPSLLYRFKIVDKAQPETQATSFGNVLFNAKLAVDDPEAILLVNQPGSDGFKVDSTPLFQVALGREWYVHTIYTVRSKDSANRGIGKRSVEYRYHSLVGQGKPQAATKSRKKREIRSSPPLAWEIGAENNRGTNIQHVALDRSSRKQILHGRVSPDGVLPRELNSPSSEVSLLTVVGGVVVGLLAVILTAVTVRMHQGRKGARRKDAPKDPGSREPMMPSVSHHSDSSEV", "length": 3172, "header": "tr|F1MFH3-1|F1MFH3_BOVIN Isoform 1 of FRAS1-related extracellular matrix protein 2 OS=Bos taurus OX=9913 GN=FREM2 PE=3 SV=3 CANONICAL=F1MFH3-1" }, "isoforms": [ { "isoform_ac": "F1MFH3-1", "url": "https://www.uniprot.org/uniprotkb/F1MFH3/entry", "sequence": { "sequence": "MQATGTPGVTARTRPAGNPTKSPPTPPTPSGLVLLLLLSLVSRVRAQPPDPGRALLSPDLAGVAGVPAEEAIVLANRGLRVPFGREVWLDPLQDLVLQVQPGDRCAVTVLDNDALAQRPGRLSPKRFPCDFGAGEVRYSHLGARSPSRDRVRLQLRYDAPGGAAVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFAYQPETQECRVGILPGLGALPRYGELLHYPQVPGSASEGDSQEPLLMDCTAFQELGVRYRHTAPSRSPNRDWVPMVVELRSRGSPVGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAECAPDLLIFNLTSPFQPGQGFLVSTDDRSLPLSSFTQRDLHLLKIAYQPPSEDSDQERLFELELEVVDPEGAASDPFSFMVVVKPMNTLAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEAVQLEVVAGLRHGHLVLLGASNGNSAPKTFTVAELAAGRVVYHHDDKDGSLSDNLVLLMVDGGRRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPQALSAIDMDSEDSLLLFVLESPSSTAGHLLLRQTHPPQGEEMLLGSPWRKQGIFYEKTVTQWRQRDITEGRLFYRHSGPHSPGPVIDQFTFRVQDNHDPPNKSGLQRFMIRIHPVDRLPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQPPMDTDENHSPAPLGTLVLTDDPSVVVAHFTQAQVNHHKIAYRPPDQELGVAARVAQFQFQVEDRAGNVAPGTFTFYLQPVDNQPPEILNTGFTVQEKGHHILSETELGVNDVDTDVAHITFTLIQVPKHGHMKLSGQVLHVGGIFHLEDIKQGRISYAHNGAESLTDSCSLEVSDRHHVVPITLRVNVRPMDGELPMLSLPAGTLGSYLDVLENRATEITANVIRGTNGDADDLMLTFLLEDPPLYGEILVNGVPAEQFTQRDILEGSVVYTHTSGEIGLLPKEDSFNLSLSDMSQEWRIGGNTIQGVTMWVTILPVDSQAPEISVGEQFIVLEGDKSAITSMHISAEDMDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAVSAFTLKDLRQGHINYVQSVHKGVEPVEDRFIFRCSDGINFSERHFFPIVIIPTNDEQPEIFIREFLVMEGMSLVVDTPILNAADADVPPDDLTFTITKFPTHGHIMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIQLTDGKHSVEKTVLIMVIPVDDETPRMAINNGLEIEIGETKIINNRILMATDLDSEDKFLVYIIRYGPGHGLLQRQTPTGVFENITLGMNFTQDEVDSNLIQYVHFGQEGIRDLIKFDVTDGINALIDRYFYVSIGSPDIVFPDVISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLESTDQPRVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHNLVVSEGEKKLITPFELTVEDRDTPDKLLKFTVTQVPVHGQLLFNNTRPAMIFTKQDLNENLISYRHDGTESSEDSFSFTVTDGSHTDFYVFPDTVFETRRPQVMKIRILAVDNRVPQIVVNKGASTLRTLATGHLGFMITSKVLKAEDRDSLHVSLRFIVTEAPRHGYLLNLGQGNHSVTEFTQADIDDMKICYVLREGANAVSDIFQFTVEDGGGNKLTKQHFRLNWAWISFEKEYYLINEDSKFLDVMLKRRGYLGETSFISIGTRDGTAKKDKDFKGKAQRQVQFNPGQTRATWRVRILSDGAHEQSETFQVVLAEPVLAALEFPAVTTVEIVDPGDESTVFIPQSEYSIEEDVGELFIPIRRSGDVSQELMVVCYTRQGTARGTVPTSVLSYSDYISRPEDHTSVIRFDKDEREKMCRVVIIDDSLFEEEETFHVLLSMPMGGRIGSEFPGAQVTIKPDKDDEPVFYFGDVEYKVDESAGSVEVRVWRSGTDLSQASSVTVTSQKTDPPSADAGTDYVGISRNLDFAPGVNMQTIRVIILDDLGQPMLEGIEQFELVLRMPMNAALGDPSKATVTINDSVSDLPKMQFKERVYTGNENDGQIVATIHRSGDTRYRSSVRCYTRQGSAQVMMDFEERPNTDISIITFLPGEIEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTIIKFGETKFSVSEPKEPGQSVVIKIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHIVEIEVIFDGVREMREAFTVHLKPDENMIAETQATKAIVYIEEMNSMADVTFPSVPQVVSLLTYDDSSRAKESAGPVSGYPVVCITACNPKYPDYEKTGSICASENINDTSTRYRWLISAPAGPDGVTSPMREVDFDTFFTSSKMITLDSIYFQPGSRVQCAARAVNADGSEGLELMSPIVTIGREEGLCQPRVPGIVGAEPFSAKLRYTGPEDSEYTNLIKLTVTMPHTDGMLPVISTKELSNFELTLSPDGTRVGNHKCSNLLDYTEVKTHHGFLTDATKNPEIIGETYPYQYSSSIRGSNTLRFYRNLNLEACLWEFVSYYDMSELLTDCGGTIGTDGQVLNLVQSYVTLRVPLYVSYVFHSPAGVGGWQHFDLKSELRLTFVYDTAILWTDGIGSPPEAELQGSLYPTSMRIGEEGRLVVNFKTEAQFHGLFVLSHPASFTSSMIMSVDHPGLTFSLRLIRSEPTYNQPVQQWSFVSDFAVRDYSGTYTVKLLPCTTPSHQEFRLPVTCNPREPITFDLDIRFQQVSDPVAAEFSLNTQMYLLSKKSLWLSDGSMGFGQESDVAFAEGDIIYGRVMVDPVQNLGDSFYCSIEKVFLCTGADGYVPKYNPTNAEYGCLADSPSLLYRFKIVDKAQPETQATSFGNVLFNAKLAVDDPEAILLVNQPGSDGFKVDSTPLFQVALGREWYVHTIYTVRSKDSANRGIGKRSVEYRYHSLVGQGKPQAATKSRKKREIRSSPPLAWEIGAENNRGTNIQHVALDRSSRKQILHGRVSPDGVLPRELNSPSSEVSLLTVVGGVVVGLLAVILTAVTVRMHQGRKGARRKDAPKDPGSREPMMPSVSHHSDSSEV", "length": 3172, "header": "tr|F1MFH3-1|F1MFH3_BOVIN Isoform 1 of FRAS1-related extracellular matrix protein 2 OS=Bos taurus OX=9913 GN=FREM2 PE=3 SV=3 CANONICAL=F1MFH3-1" }, "locus": { "chromosome": "12", "start_pos": 23448838, "end_pos": 23297838, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022647.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022647.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022647.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022647.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1111, "start_aa": "Thr", "end_pos": 1111, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1111", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 25, "start_aa": "Thr", "end_pos": 25, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr25", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 28, "start_aa": "Thr", "end_pos": 28, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr28", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:527601", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527601", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XFN7-1", "protein_name": "FRAS1 related extracellular matrix 2", "gene_name": "FREM2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQAFLAVPQRLPAGLLLLAGCVCLGLPDPPLPPDRAAVSSPWGPEAATPVVVANRGLRVPLGRSAWLDPTRDLVLQVQPGDRCHLTVLDEDPLWQRPGRLSPRRFPCDFGPRDVRYSHLGGRSPARDRVRLQLRYDSPSRALVLPLVLEVEVLFTQLEIVTRNLPLVVERLRGTSSPLDARSLEFAFEPGRQRCRVGLLPSLTGLPRYGEILNYPTAVAMPVGGSVEAVGDGPVPASMWDCEEFLRLGLRYRHTAAGSSPNRDLVPLVAELWEAAGGRALLKREYFQVLVRIRGGMENVAPKPSFMAMLMMEVDQFVLTALTPDMLAAEDTESPPDLLLFNITSPFGLGQGYMVSTDDRSLPISSFSQRDVRELRIAYQPPVEDSDRERLFELELEVLDPEGAASEPFAFVIVVKPMNTLAPVVTRNTGLVLYEGQSRPLSDPGPSPNLVISDEDDLEQVQVSVVAGLRHGHLTLLEDTPASAAPRKHFTVAELAAGRVIYQHDGSESPLSDNLVLRLEDGGSRHRVEFLFPITLVPTDDQPPLLNANTGLAIAEGETVPITTRALSATDIDSQDAILLFTVESGPSAGQLLLRQAQPPPGWEEEEEDEGFSWRRVSGVVGSSLIYEKPVREWLQQDIVEGRLYYHHFGPHSPGPGVVLDQFVFRVQDDNDPPNRSGPQTFVIRVHPVDRLAPELHSSSSLHLIVAEQQVTPLRRKHLCYTDQDSGDRELRYTVTQPPTDTDSNHPPDEHGARLGSLVLTEDHSVEVTHFTQAQINHHKISYRPPQEELGVAPHLIQFHYQVEDAAGNAAEGTFTIYLQPVDNQPPEITNTGFTLPEGGSHVLSPTELDASDTDTELAHLRFILTQAPRYGQLQLSGYSLILGGAFGLEDIRQGRVVYVHSGAETNSDTCRLDVSDGVHVVPITLKMNVHPVDDEIPTLRLAPGTVGSYLDVLENGAAEITANVIQGTDEDTDDLMLTFIVEDPPQHGSILVQGVPAERFSQRDVLDGAVVYAHTSGEIGLLPKEDTFNLTLSDLSEEWNIRGNVVQGVSVLVTILPVDNKAPEIFVGEQFRVMEGDKRVITPAHLRAEDVDTPSDDILCTIVAQSTSGYVENISPAPGSEKSRAGIAISAFTLKDLRQRHIFYVQSIHKGVEPVEDRFAFRCSDGINFSQRHVFPIVIMPMNDEEPEIFIREFVVMEGMSLVIDTPILNAVDGDIPADKLTFTITRLPRHGHIVNQLINGTVLAESFTLDQITESSNILYEHDDSETREDNFEVKLSDGKHTTVKTIFIMVIPVDDETPRMAINDGLEIEIGETRTIHNRILKATDLDSEDKTLTYIVRYGPGQGLLQRLKPSGGVENITLGMNFTQDEVDRNLIRYMHFGREGVRDLIKFDVTDGINPLIDRYFYVTVGSIDIVFPDVISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPVRGHLECTDQPGVPISTFTQLLLAGNKIYYIHTSEDEVKMDSFEFEVTDGYNPVFRTFRISISDVDNKKPIVTIHNLVVSENEYKLITPFELTVEDRDTPDPLLKFVITQIPVHGQIMFNNSKPVTTFTKQDLNENLISYKHDGTESVEDSFSFTVTDGTHTDFYVFPNTVFETRRPQTMKIRIMAVDNSIPQIVTNRGAQTLRILATGHVGFLITNKVLKVEDRDSLHIALKIRITEGPRHGFLIHLGKGNHSISQFTQADIDDMKICYVLRAGDNATSDIFHFIVEDSGGNKLKNQHFRLNWAWISLEKEYYLVNEDSKYLDVVLKRRGYLGETSFISISTRDGTAKKDKDFRGKAQKQVQFNPGQTLATWRVRILSDGEHERSESFQIVLSEPVMAVLEFPSVSTVEIIDPGDESTVFIPQSTYTIEEDVGELFIPVRRSGDVSQELMVICYTQQGTATGTAPTSVLSYSDYISRPEDHNSVLRFDKDEREKTCRVVIIDDSLYEEAETFDVLLSMPMGGRIGTEFASTRITIVPDKDDEPAFYFGNDEYYVDESAGYVEVHVWRTGTDLSKAASVTVRSRKSESRTAEAGVDYVGISRNLDFAPGVSMQTFRVVILDDLGQPVLEGAEKFELVLRMPMNAALGEPSKATIFINDSVSDLPKMQFKEPVYVVNENDGQISAMIYRSGDIQYTSTVRCYTRQGSAQVMIDFEERPNTDSSIITFLPGETEKPCTLVLMDDTFHEEDEELRLVLGTPRSDSSFGASIGEQNETLIKIQDDADKAIIKFGETKFSVSEPKDTRQVAVVKIPVIRLGDTSKVSVVRVHTKDGSAISGEDYHPISEEIEFKEGETQHFVEIEVLFDGVREMREAFTVHLKPDENMVAEIQTAKAIVYIEEMNSMADVTFPSVPQVASLLIYDDTSRAKDRTSPVAGYPVICITACNPKYEDFDKTGSICASENINNTLTQYRWLVSAPTGPDGVTSPMKEVDFDTFFTSSKMITLDSIYFQAGSRVQCAARAVNSDGNEGLELMSPIVTISTSEGLCQPRVSGVVGAEPFSAKLRYTGPEDPAYANLIKLTVTMPHIDGMLPVISTRELSNFELTLSPDGTRVGNHKCSNLLDYTEVKTHHGFLTDATKNSDVIGETIPYQYSPAIRGFNTLRFYRNLNLEACLWEFVSYYDMSELLTDCGGTIGTDGQVLNLVQSYVTLRVPLYVSYVFHSPVGVGGWQHFDLQSELRLTFVYDTAILWKDGIGSPPEAELQGSLYPTSMRISEEGRLVVNFKTEARFHGLFVMSHPASSLTSMVMSADHPSLTFSLSLIRSEPTYNQPVQQWSFVSDFAVRDYSGTYMVKLIACTTAPHQEYSLPVICNPREPITFDLDIRFQQVSDPVAAEFSLNTQMFLLSKKTLWLSDGSMGFGQESDVAFSEGDVIYGRVMVDPVQNLGDSFYCSIEKVFLCTGADGYVPKYNPSNTEYGCLADSPSLLYRFKIVDKAQPETQATSFGDVLFNAKLAIDDPEAISLVKQPGSDGFKVDSTPLFQVSLGREWYVHTIYTVRSKENANRGIGKRSVEQQYHSLFSGGSPAGSTQRRHKRGVVGAPELARDIGVENNRGTNIQHIALDRTSRKQVPQREVAVSGVLPRELNSQSSGVSVVTIVGGAAAIFLAICLITIIILLLKRRQNSEKKEATKKSGSNEPMMLPNSYTSDSSEV", "length": 3168 }, "evidence": [ { "id": "F1MFH3", "url": "https://omabrowser.org/oma/group/F1MFH3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZG74-1", "protein_name": "FRAS1-related extracellular matrix protein 2", "gene_name": "Frem2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGPRGALGHPPGPALPLGGPRRRRAEFPALPIGLWRSLQRLALHTRRVNCRNSNACNLHATRTPGMATRGRWTAKYSNFQSILTQSPRLLLLLLSLVSRVSTQDAAPGAAFLSLGLSGTSGVPTEEAIVVANRGLRVPFGREVWLDPLRDLVLQVQPGDRCTVAVLDNDALAQRPGRLSPKRFACDYGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAIVLPLALEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFAYQPETEECRVGILSGLSALPRYGELLHYPQVPGGTGERGSSETPLMDCKAFQELGVRYRHTALSHSPNRDWLPMVVEIHSRGAPVGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESNPDLLIFNLTSAFQPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELELEVVDPEGAASDPFAFMVVVKPMNTLAPVVTRNTGLILYEGQYRPLTGPVGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGSPSSDPAPKTFTVAELAAGQVVYQHDDRDGSLCDNLVLRMSDGGGRHQVQFLFPITLVPVDDQPPVLNANTGLTVAEGDTVPIPPSTLSATDMDSDDSQLLFVLEPPFSSSGRLLLRQTHAPQEEQGLWHKQGSFYERMVTEWRQQDITEGKLFYRHSGPHSPGPVMDQFLFRVQDNQDPPNQSGIQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTPLRKRWLHYTDLDTDDRELHYTVTQPPTDTDENHSPAPLGTLVFTDNPSVVVTHFTQAQVNHHKIAYRPPGQELGVAARVAQFQFQVEDRAGNVAPGTFTLYLQPVDNQPPEIVNTGFTVEEKGHHVLRETELHVSDVDTDVAHISFTLTQAPKHGHLQISGRPLHVGGQFRLEDIKQGRISYLNSGDESLTDSCSLEVSDRHHVVPITLRVNVRPADREGAMSVLPAGTLESYLDVLENGATEVTANIIKGTYRDTDDLMLTFLLEGPPLYGEILVHGAPAEQFTQRDILEGSVVYAHTSGEIGLLPKADSFNLSLSAMSQEWRIGSSVIQGVTVWVTILPVDSQAPEISVGEQFVVLEGDKSLISLTHLSAEDVDSLMDDLLCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFTLKDLRQGHINYVQSVHRGVEPVEDRFIFRCSDGINFSERQIFPIVIIPTNDEQPEMFMREFMVMEGMSLVVDTPILNAADADIPRDDLTFTITRFPTHGHIMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHSVEKMALIMVIPVDDETPRMAINNGLEIEIGETKVINNKVLAATDLDSDDKSLVYIIRYGPGHGLLQRRKPLGVFENITLGMNFTQDEVDRNLIQYVHFGQEGIRDLIKFDVTDGTNALIDRYFYVSIGSVDIVFPDVVSKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQRGLSITSFTQLQLAGNKIYYIHTAEDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHNLVVSESESKLITPFELTVEDRDTPDRLLKFIVTQVPVHGHLLFNNTRSVMVFTKQDLNENLISYKHDGTESTEDSFSFTVTDGTHSDFYVFPDTVFETRRPQVMKIRVLPVDNRVPQIVVNKGASTLRTLPTGHLGFMITSKILKVQDRDSLHFSLRFIVTEAPQHGYLLNLGQGNHSVTQFTQADIDDMKICYVLRERANATSDVFHFIVEDDGGNRLTNQHFRLNWAWISFEKEYYLINEDSKFLDIVLKRRGYLGETSFISISTRDGTAEKDKDFKGKAQKQVQFNPGQTRASWRVRILSDGEHEHSETFQVVLSEPVLAVLEFPEVTTVEIIDPGDESTVFIPQSEYSVEEDVSELFIPIRRSGDISQELMVICYTQQGTATSTVRTSVLSYSDYISRPEDHSSVIRFDKDEREKMCRVVVIDDSLYEEEETFQVLLSMPMGGRIGNKFPGANVTILTDKDDEPAFYFGDTQHSVDESAGYVEVQVWRTGTDLTKPSSVTVRSRKTEPPSADAGTDYVGISRNLDFAPGVSMQTVRVVILDDLGRPVLEGIEKFELVLRMPMNAALGEPSKATVSINDSASDLPKMQFKERVYTCSENDGHVVAMIYRSGDLQHRSSVRCYTRQGSAQVMMDFEERPNTDISIVTFLPGESEKPCVLELMDDDLYEDVEELRLVLGTPQGSSAFGAAVGEQNETLIKIQDDADKAVIKFGETKFSVTEPSRPGESVVVKIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHTVEIEVIFDGVREMREAFTVHLKPDENMVAETQTTKAIVYIEEINSMADVTFPSVPHIVSLMVYDDTFKGREDAGPVSGYPIICITACNPKYPDYDKTGSICASENINDTLTRYRWLTSAPTGPDGVASPMREVDFDTFFTSSKMITLDSIYFQPGSRVQCAARAVNTNGNEGLELMSPIVTIAREEGLCQPRVPGVVGAEPFSAKLRYTGPEDPDFANLIKLTVTMPHIDGMLPVISTRELSNFELTLSPDGTRVGNHKCSNLLDYSEVRTHHGFLTNATKNPEVIGETYPYQYSAPVRGSSTLRFYRNLNLEACLWEFVSYYDMSELLADCGGTIGTDGQVLNLVQSYVTLRVPLYVSYVFHSPVGVGGWQHFDLKSELRLTFVYDTAILWNHGIGSPPEAELQGSLYPTSMRIGEEGRLAVNFKTEAQFHGLFVLSHPASFTSSLIVSADHPGLTFSLRLIRSEPTYNQPVQQWSFISDFAVRDYSGTYTVKLVPCTTPSNQEYRLPVTCNPREPVTFDLDIRFQQVSDPVAAEFSLNTHMYLLSKKSLWLSDGSMGFGQESDVAFAEGDVIYGRVMVDPVQNLGDSFYCSIEKVFLCTGDDGYVPKYSPANAEYGCLADSPSLLHRFKIVDKAQPETQATSFGDVLFNAKLAVDDPEAALLVNQPGSDGFKVDSTPLFQVALGREWYIHTIYTVRSKGTSHRGIGKRSLEYQYHSVVQHGPPQATTKSWKKRAVRSTPSLAGEIGAENNRGTNIQHISLDRRGKRQVPHGRIPPDGILPWELNSPSSEMSLVTVLGGISVGLLAVCLAVAVAVMCRNRSIKGKDAPKGSGSTEPMMSPQSHYNDSSEV", "length": 3224 }, "evidence": [ { "id": "F1MFH3", "url": "https://omabrowser.org/oma/group/F1MFH3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RS31-1", "protein_name": "FRAS1-related extracellular matrix protein 2", "gene_name": "FREM2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MHAAPTPGITACGRHAANPTNFQPMLPPPPGLVLLLLLLLSPVSSVRAQPAAPGRALLSPNLAGVAGVPAKEAVVLANRGLRVPFGREVWLDPLQDLVLQVQPGDRCSVTVLDNDALAQRPGRLSPKRFPCDFGAGEVRYSHLGARSPSRDRVRLQLRYDAPGGAAVLPLVLEVEVVFTQLEIVTRNLPLVVEELLGTSNALDARSLEFAYQPQTEECRVGILSGLGALPRYGELLHYPQVPGHASDRGTQEPLLMDCRAFQELGVRYRHTAPSRSPNRDWVPMVVELRSRASPVGSPALKREHFQVLVRIRGGTENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPPDLLIFNLTSPFQPGQGYLVSTDDRSLPLSSFTQRDLHLLKIAYQPPFEDSDRERLFELELEVVDPEGAASDPFAFMVVVKPMNTLAPVVTRNTGLILYEGQSRPLTGPAGSGPDNLVISDEDDLEAVQLEVVAGLRHGHLVLPGASSGNSAPKTFTVAELAAGQVVYHHDDKDGSLSDNLVLRMVDGGRRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPQALSATDMDSDDALLLFVLEPPSSTSGHLLLRQTHPPQEEEGLIRGPWRNQGTFYEKMVTEWRQRDITEGRLFYRHSGPHSPGPVMEQFTFRVQDNHDPPNQSGPQRFVIRIHPVDRLPPEVGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQPPMDTDENHSPAPLGTLVLTDNPSVVVAHFTQAQVNHHKIAYRPPDQELGVAARVAQFQFQVEDQAGNVAPGTFTLYLQPVDNQPPEILNTGFTIQEKGHHILSETELSVKDVDTDVAHITFTLTQAPRHGHVKVSGQILRVGEIFHLEDIKQGRISYIHNGAETLTDSCSLEVSDRHHVVPITLRVSVRPVDDEVPMLSLPDGTLGSYLDVLENGATEITANVIKGTDEDTDDLMLTFLLEDPPLYGEILVNGVPAEQFTQRDILEGSVVYAHTSGEMGLLPKEDSFNLSLSDMSQEWRIGGNAIRGVTVWVTILPVDNQAPEVSVGERFIVMEGDKSVITSMHISVEDTDSLNDDILCTIVIQPTSGYLENISPSPGSEKSRAGIAISAFTLKDLRQGHINYVQSVHKGVEPVEDRFIFRCSDGINFSERHFFPIVIIPTNDEQPEIFMREFIVMEGMSLVIDTPILNAADADIPPDDLTFTITKFPTHGHIMRQLINGTILVESFTLDQIIESSSIIYEHDDSETQEDSFVIRLTDGKHSVEKVVLIMVIPVDDETPRMAINNGLEIEIGETKVINNKILMATDLDSEDKSLVYVIRYGPRHGLLQIQKSSGVFENITLGMNFTQDELDRNLIRYIHFGQEGIRDLIKFDVTDGINALIDRYFYVSVGSLDIVFPDVISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLECSDQPGVSIMSFTQLQLAGNKISYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIQHLVVSEGENKLITPFELTVEDRDTPDKLLKFTLTQVPIHGQLLFNNTRPTMIFTKQDLNENLISYRHDGTETREDSFSFTVTDGSHTEFYVFPDTVFETRRPQVMKIQILAVDNSVPQIAVNKGASTLRSLATGHLGFMITSKVLKVEDRDSPQFSLRFIVTEAPRHGYLLNLGEGNHSVTQFTQADIDDLKICYVLREGANATSDVFHFTVEDSGGNKLTKQHFRLNWAWISFEKEYYLINEDSKFLDVVLKRRGYLGETSFISIGTRDGTAKKDKDFKGKAQKQVQFNPGQTRATWRVRIMSDGEHEQSETFQVVLSEPVLAALEFPEVTTVEIVDPGDESTVFIPQAEYSIEEDIGELFLPIRRSGDVSRELMVICYTQQGTARGTVPTSVLSYSDYISRPEDHTSVIRFDKDEREKMCRVVIIDDSLYEEEETFRVVLSMPMGGRLGSEFPGAQVTIIPDKDDEPVFYFGDVAYSVDESAGYVELLVWRTGTDLSKASSVTVRSRKTDPPSAEAGTDYVGISRNLDFAPGVNMQPVRVIILDDLGQPVLEGVEKFELVLRMPMNAALGDPSKATVSINDSGSDLPKMQFKERVYTGNENDGQVVAVIHRSGDIQFRSSVRCYTRQGSAQVMMDFEERPNTDLSVITFLPGETEKPCILELMDDAVHEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTIIKFGETKFSVREPQAPGQSAVVKIPVIRQGDTSKVSTVRVHTKDGSATSGEDYHPVSEEIEFKVGETQHIVEIEVIFDGVREMREAFTVHLKPDENMIAETQVTKAIVYIEEMNSMADVTFPSVPQIVSLLMYDDTSKAKESAGPVSGYPVVCITACNPKYSDYDKTGSICASENINDTLTRYRWLISAPTSPDGVTSPMREVDFDTFFTSSKMITLDAIYFQPGSRVQCAARAVNADGSEGLELMSPIVTIGREEGLCQPRVPGIVGAEPFSAKLRYTGPEDPEYANLLKLTVTMPHTDGMLPVISTKELSNFELTLSPDGTRAGNHKCSNLLDYTEVKTHHGFLTDATKNPDVIGETYPYQYSSSIRGSRTLRFYRNLNLEACLWEFVSYYDMSELLTDCGGTIGTDGQVLNLVQSYVTLRVPLYVSYVFHSPVGVGGWQHFDLQSELRLTFVYDTAILWNEGVGSPPEAELHGSLYPTSMRIGEEGRLVVNFKTEAQFHGLFVLSHPASFTSSMIMSADHPGLTFSLRLIRSEPTYNQPVQQWSFVSDFAVRDYSGTYTVKLLPCTTPSHQEYRLPVTCNPREPVTFDLDIRFQQVSDPVAAEFSLNTQMYLLSKKSLWLSDGSMGFGQESDVAFAEGDVIYGRVMVDPVQNLGDSFYCSIEKVFLCTGADGYVPKYSPANAEYGCLADSPSLLYRFKIVDKAQPETQATSFGNVLFNAKLAVDDPEAILLVNQPGSDGFKVDSTPLFQVALGREWYIHTIYTVRSKDNAKRGIGRRSVEYEYHSLVSSGEPQAMAGSRRKREVRSPPALAREIGAENNRGTNIQHVALDRSSRRRSPQGRAPPHGLPPRELSSPSSEVSLVAVMGGGAVGLLAVGLMALAVVLFKGKKSARRKGAPQGSGSSEPMMPRPGLQSDSSEV", "length": 3174 }, "evidence": [ { "id": "F1MFH3", "url": "https://omabrowser.org/oma/group/F1MFH3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q5SZK8-1", "protein_name": "FRAS1-related extracellular matrix protein 2", "gene_name": "FREM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHSAGTPGLSSRRTGNSTSFQPGPPPPPRLLLLLLLLLSLVSRVPAQPAAFGRALLSPGLAGAAGVPAEEAIVLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQRPGRLSPKRFPCDFGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFAFQPETEECRVGILSGLGALPRYGELLHYPQVPGGAREGGAPETLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVVELRSRGAPVGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVDGGGRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQELLRGLWRKEGAFYERTVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQPPTDTDENHLPAPLGTLVLTDNPSVVVTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVEDRAGNVAPGTFTLYLHPVDNQPPEILNTGFTIQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRVSYAHNGDKSLTDSCSLEVSDRHHVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYGEILVNGIPAEQFTQRDILEGSVVYTHTSGEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCSDGINFSERQFFPIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLGMNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHKLVVSESENKLITPFELTVEDRDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFTKQDLNENLISYKHDGTESSEDSFSFTVTDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSITQFTQADIDDMKICYVLREGANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTVHLKPDENMIAEMQLTKAIVYIEEMSSMADVTFPSVPQIVSLLMYDDTSKAKESAEPMSGYPVICITACNPKYSDYDKTGSICASENINDTLTRYRWLISAPAGPDGVTSPMREVDFDTFFTSSKMVTLDSIYFQPGSRVQCAARAVNTNGDEGLELMSPIVTISREEGLCQPRVPGVVGAEPFSAKLRYTGPEDADYTNLIKLTVTMPHIDGMLPVISTRELSNFELTLSPDGTRVGNHKCSNLLDYTEVKTHYGFLTDATKNPEIIGETYPYQYSLSIRGSTTLRFYRNLNLEACLWEFVSYYDMSELLADCGGTIGTDGQVLNLVQSYVTLRVPLYVSYVFHSPVGVGGWQHFDLKSELRLTFVYDTAILWNDGIGSPPEAELQGSLYPTSMRIGDEGRLAVHFKTEAQFHGLFVLSHPASFTSSVIMSADHPGLTFSLRLIRSEPTYNQPVQQWSFVSDFAVRDYSGTYTVKLVPCTAPSHQEYRLPVTCNPREPVTFDLDIRFQQVSDPVAAEFSLNTQMYLLSKKSLWLSDGSMGFGQESDVAFAEGDIIYGRVMVDPVQNLGDSFYCSIEKVFLCTGADGYVPKYSPMNAEYGCLADSPSLLYRFKIVDKAQPETQATSFGNVLFNAKLAVDDPEAILLVNQPGSDGFKVDSTPLFQVALGREWYIHTIYTVRSKDNANRGIGKRSVEYHSLVSQGKPQSTTKSRKKREIRSTPSLAWEIGAENSRGTNIQHIALDRTKRQIPHGRAPPDGILPWELNSPSSAVSLVTVVGGTTVGLLTICLTVIAVLMCRGKESFRGKDAPKGSSSSEPMVPPQSHHNDSSEV", "length": 3169 }, "evidence": [ { "id": "F1MFH3", "url": "https://omabrowser.org/oma/group/F1MFH3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6NVD0-1", "protein_name": "FRAS1-related extracellular matrix protein 2", "gene_name": "Frem2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASRARRTAKFSSFQPILAQSPRLLLLLLLLSLVSYVSTQAAGPGAALQSLGLSGTSGVPTEEAIVVANRGLRVPFGREVWLDPLRDLVLQVQPGDRCTVTVLDNDALAQRPGHLSPKRFACDYGPGEVRYSHLGARSPSRDRVRLQLRYDAPGGAIVLPLALEVEVVFTQLEIVTRNLPLVVEELLGTSNALDDRSLEFAYQPETEECRVGILSGLSALPRYGELLHYPQVQGGAGDRGTSKTLLMDCKAFQELGVRYRHTAPSRSPNRDWLPMVVELHSRGAPEGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESDPDLLIFNLTSAFQPGQGYLVSTDDRSLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELELEIVDPEGAASDPFAFMVVVKPMNTLAPVVTRNTGLILYEGQYRPLTGPIGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGSPSSDSAPKTFTVAELAAGQVVYQHDDKDGSLSDNLVLRMSDGGGRHQVQFLFPITLVPVDDQPPVLNANTGLTVAEGETVPIPPLTLSATDIDSDDSQLVFVLLPPFSSLGHLLLRQRHVPQEEQGLWQKQGSFYERTVTEWRQQDITEGKLFYRHSGPHSPGPVMDQFMFRVQDNHDPPNQSGIQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTPLRKRWLHYTDLDTDDRELQYTVTQPPTDTDENHSPAPLGTLVFTDNPSVVVSHFTQAQVNHHKIAYRPPGQELGVAARVAQFQFQVEDRAGNVAPGTFTLYLQPVDNQPPEIVNTGFTVEEKGHHILRETELHVSDVDTDVTHISFTLTQAPKHGHMQISGRPLHVGGQFHLEDIKHGRISYWNSGDESLTDSCSLEVSDRHHVVPITLRVNVRPGDREGPMSVLPAGTLESYLDVLENGATEVTANIIKGAYQGTDDLMLTFLLEGPPSYGEILVNGAPAEQFTQRDILEGSVVYAHTSGEIGLLPKADSFNLSLSAMSQEWRIGSSIVQGVTVWVTILPVDSQAPEISLGEQFVVLEGDKSVISLTHLSAEDMDSLKDDLLCTIVIQPTSGYVENISPAPGSEKSRAGVAISAFTLKDLRQGHINYVQSVHRGVEPVEDRFIFRCSDGINFSERQIFPIVIIPTNDEQPEMFMREFMVMEGMSLVVNRLILNAADADIPRDDLTFTITRFPTHGHVMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHSVEKMVLIVVIPVDDETPRMTINNGLEIEIGETKVINNKVLMATDLDSDDKSLVYIIRYGPGHGLLQRQKPLGAFENITLGMNFTQDEVDRNLIQYVHFGQEGIRDLIKFDVTDGTNALIDRYFYVTIGSVDIVFPDVVSKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLECTDRRGLSITSFTQLQLAGNKIYYIHTAEDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHNLVVSESESKLITPFELTVEDRDTPDRLLKFIVTQVPVHGHLLFNNTRSVMVFTKQDLNENLISYKHDGTESTEDSFSFTVTDGTHSDFYVFPDTVFETRRPQVMKIQVLPVDNSVPQIVVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHFSLRFIVTEAPQHGYLLNLGQGNHSVTQFTQADIDDMKICYVLRERANATSDMFHFIVEDDGGNRLTNQHFRLNWAWISFEKEYYLINEDSKFLDIVLTRRGYLGETSFISIGTRDGTAEKDRDFKGKAQKQVQFNPGQTRASWRVRILSDGEHEHSETFQVVLSEPVLAILEFPTVTTVEIIDPGDESTVFIPQSEYSVEEDVGELFIPIRRSGDISRELMVICYTQQGTATSTVRTSVLSYSDYISRPEDHSSVIRFDKDEREKMCRILVIDDSLYEEEETFQVLLSMPMGGRIGDKFPGANVTILTDRDDEPAFYFGDTQYSVDESAGYVELQVWRTGTDLSKPSSVTVRSRKTESLSADAGTDYVGISRNLDFAPGVNMQTVRVVILDDLGRPILEGIEKFELVLRMPMNAALGEPSKATVSINDSASDLPKMQFKERVYTCNENDGRVVAMIYRSGDIQHRSSVRCYTRQGSAQVMMDFEERPNTDVSTVTFLPGEMEKPCVLELMDDAVYEDVEELRLVLGTPQGSSAFGAAVGEQNETLIKIQDEADKAVIKFGETKFSVTEPSRPGESVVVKIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHTVEIEVIFDGVREMREAFTVHLKPDENMVAETQATKAIVYIEEIHSMADVTFPSVPHIVSLLIYDDPSKGREDTGPVSGYPVVCITACNPKYPDYEKTGSICASENINDTLTRYRWLISAPAGPDGVTSPMREVDFDTFFTSSKMITLDSIYFQPGSRVQCAARAVNTNGNEGLELMSPIVTIGREEGLCQPRVPGVVGAEPFSAKLRYTGPEDPDFANLIKLTVTMPHIDGMLPAISTRELSNFELTLSPDGTRVGNHKCSNLLDYNEVKTHHGFLTNATKNPEVIGETYPYQYSVPVRGSSTLRFYRNLNLEACLWEFVSYYDMTELLADCGGTIGTDGQVLNLVQSYVTLRVPLYVSYVFHSPVGVGGWQHFDLKSELRLTFVYDTAILWNHGIGSPPEAELQGSLYPTSMRIGEEGRLAVNFKTEAQFHGLFVLSHPASFTSSLIVSADHPGLTFSLRLIRSEPTYNQPVQQWSFVSDFAVRDYSGTYTVKLVPCTTPSNQEYRLPVTCNPREPVTFDLDIRFQQVSDPVATEFSLNTHMYLLSKKNLWLSDGSMGFGQESDVAFAEGDVIYGRVMVDPVQNLGDSFYCSIEKVFLCTGDDGYVPKYSPANAEYGCLADSPSLLHRFKIVDKAQPETQATSFGDVLFNAKLAVDDPEAVLLVNQPGSDGFKVDSTPLFQVALGREWYIHTIYTVKSKDNTHRGIGKRSLEYQYHSVVHPGPPQATTKSWKKRAVRSTPSLAGEIGAENNRGTNIQHISLNRRGKRQVPHGRIPPDGILPWELNSPSSEVSLVTVLGGLTVGLLTVCLAVAAAVMCRNRSTKGKDTPKGSGSTEPMMSPQSHYNDSSEV", "length": 3160 }, "evidence": [ { "id": "F1MFH3", "url": "https://omabrowser.org/oma/group/F1MFH3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MFH3", "url": "https://www.uniprot.org/uniprotkb/F1MFH3" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "F1MFH3", "url": "https://www.uniprot.org/uniprotkb/F1MFH3" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "F1MFH3", "url": "https://www.uniprot.org/uniprotkb/F1MFH3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MFH3", "url": "https://www.uniprot.org/uniprotkb/F1MFH3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "F1MFH3", "url": "https://www.uniprot.org/uniprotkb/F1MFH3" } ], "pmid": "" }, { "name": "cell communication", "id": "GO:0007154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007154", "evidence": [ { "database": "UniProtKB", "id": "F1MFH3", "url": "https://www.uniprot.org/uniprotkb/F1MFH3" } ], "pmid": "" }, { "name": "epithelial structure maintenance", "id": "GO:0010669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010669", "evidence": [ { "database": "UniProtKB", "id": "F1MFH3", "url": "https://www.uniprot.org/uniprotkb/F1MFH3" } ], "pmid": "" }, { "name": "eye development", "id": "GO:0001654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001654", "evidence": [ { "database": "UniProtKB", "id": "F1MFH3", "url": "https://www.uniprot.org/uniprotkb/F1MFH3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1033, "end_pos": 1035, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1117, "end_pos": 1119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1172, "end_pos": 1174, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1244, "end_pos": 1246, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1363, "end_pos": 1365, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1369, "end_pos": 1371, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1584, "end_pos": 1586, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1716, "end_pos": 1718, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2121, "end_pos": 2123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2236, "end_pos": 2238, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2427, "end_pos": 2429, "annotation": "n_glycosylation_sequon" }, { "start_pos": 358, "end_pos": 360, "annotation": "n_glycosylation_sequon" }, { "start_pos": 682, "end_pos": 684, "annotation": "n_glycosylation_sequon" }, { "start_pos": 752, "end_pos": 754, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFH3" }, { "id": "SM00237", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00237" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Calx-beta", "eco_id": "ECO_0000259", "start_pos": 1759, "end_pos": 1858, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 25, 28, 1111 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1033, "end_pos": 1035 }, { "start_pos": 1117, "end_pos": 1119 }, { "start_pos": 1172, "end_pos": 1174 }, { "start_pos": 1244, "end_pos": 1246 }, { "start_pos": 1363, "end_pos": 1365 }, { "start_pos": 1369, "end_pos": 1371 }, { "start_pos": 1584, "end_pos": 1586 }, { "start_pos": 1716, "end_pos": 1718 }, { "start_pos": 2121, "end_pos": 2123 }, { "start_pos": 2236, "end_pos": 2238 }, { "start_pos": 2427, "end_pos": 2429 }, { "start_pos": 358, "end_pos": 360 }, { "start_pos": 682, "end_pos": 684 }, { "start_pos": 752, "end_pos": 754 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1346 }, { "field": "total_sites", "count": 1100 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1296 }, { "field": "total_sites", "count": 1070 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 50 }, { "field": "total_sites", "count": 46 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 15 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MFI2-1", "uniprot_ac": "F1MFI2", "uniprot_id": "F1MFI2_BOVIN", "mass": { "chemical_mass": 74261.0, "monoisotopic_mass": 74261.0 }, "refseq": {}, "gene_names": [ { "name": "CD180", "type": "recommended", "evidence": [ { "id": "F1MFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFI2" } ] } ], "protein_names": [ { "name": "CD180 antigen", "type": "recommended", "evidence": [ { "id": "F1MFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFI2/entry#names_and_taxonomy" } ] }, { "name": "Radioprotective 105 kDa protein", "type": "synonym", "evidence": [ { "id": "F1MFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFI2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Pattern recognition receptor predominantly expressed on B-cells, dendritic cells, and certain monocytes/macrophages, structurally resembling Toll-like receptors (TLRs) that plays a role in modulating immune responses. While ressembling a TLR, lacks the intracellular TIR (Toll/IL-1R) signaling domain and thus does not directly transduce signals. Instead, modulates immune responses, often in conjunction with other TLRs. For example, in cooperation with MD-1/LY86, interacts directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligand.", "evidence": [ { "database": "UniProtKB", "id": "F1MFI2", "url": "https://www.uniprot.org/uniprotkb/F1MFI2#function" }, { "database": "UniProtKB", "id": "ARBA00094469", "url": "https://www.uniprot.org/uniprotkb/ARBA00094469#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFI2", "url": "https://www.uniprot.org/uniprotkb/F1MFI2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD180", "url": "https://www.uniprot.org/uniprotkb/F1MFI2", "locus": { "chromosome": "20", "start_pos": 12432394, "end_pos": 12417942, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006360", "url": "https://www.ensembl.org/id/ENSBTAG00000006360" } ] } } ], "crossref": [ { "id": "F1MFI2", "url": "https://alphafold.ebi.ac.uk/entry/F1MFI2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006360", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006360", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041281", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041281", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FLRWKYQ", "url": "https://omabrowser.org/oma/group/FLRWKYQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MFI2", "url": "https://www.orthodb.org/?gene=F1MFI2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24365", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24365", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24365:SF541", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24365:SF541", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18831", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18831", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-166016", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-166016", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MFI2", "url": "https://www.uniprot.org/uniprotkb/F1MFI2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFI2-1", "url": "https://www.uniprot.org/uniprotkb/F1MFI2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPCVSCFLLAVLISAGCKAIPSSDPKCTEKEGNRTYNCENLGLREIPDTLPNTTEVLEFSFNFLPTIQNTTFSRLINLIFLDLTRCQINWVHEDTFQSHHQLNTIVLTGNPLIFMAETSLTGPKFLKHLFLTQTGISNLEFIPVHNLENLESLHLGSNHISSINLPENFPTQNLKVLDFQNNAIHYISRKDTNSLEQATNLSLNFNGNDIKGIEPGAFSSKIFQSLKFGGSLNLFIIFKGLQNSTLQSLWLGTFEDTDDQYLTSATFEGLCDMSVESINLQKHRFSDLSSSTFRCFTRVQELDLTAAHLNGLPSGIEGMNSLKKLVLNANSFDQLCQINAASFPSLRDLYIKGNMRKLDLGTRCLEKLENLQKLDLSHSDIEASDCCNLQLKNLRHLQYLNLSYNEPLGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQNLHLLRVLNLSHCLLDTSNQHLLAGLQDLRHLNLQGNSFQDGSISKTNLLQMVGSLEILILSSCNLLSIDQQAFHGLRNVNHLDLSHNSLTGDSMDALSHLKGLYLNMASNNIRIIPPHLLPALSQQSIINLSHNPLDCTCSNIHFITWYKENLHKLEDSEETTCANPPSLRGVKLSDVKLHCGITGVGIFFIVVFVFLLILLLIFSVKFILRWKYQHI", "length": 661, "header": "tr|F1MFI2-1|F1MFI2_BOVIN Isoform 1 of CD180 antigen OS=Bos taurus OX=9913 GN=CD180 PE=3 SV=1 CANONICAL=F1MFI2-1" }, "isoforms": [ { "isoform_ac": "F1MFI2-1", "url": "https://www.uniprot.org/uniprotkb/F1MFI2/entry", "sequence": { "sequence": "MAPCVSCFLLAVLISAGCKAIPSSDPKCTEKEGNRTYNCENLGLREIPDTLPNTTEVLEFSFNFLPTIQNTTFSRLINLIFLDLTRCQINWVHEDTFQSHHQLNTIVLTGNPLIFMAETSLTGPKFLKHLFLTQTGISNLEFIPVHNLENLESLHLGSNHISSINLPENFPTQNLKVLDFQNNAIHYISRKDTNSLEQATNLSLNFNGNDIKGIEPGAFSSKIFQSLKFGGSLNLFIIFKGLQNSTLQSLWLGTFEDTDDQYLTSATFEGLCDMSVESINLQKHRFSDLSSSTFRCFTRVQELDLTAAHLNGLPSGIEGMNSLKKLVLNANSFDQLCQINAASFPSLRDLYIKGNMRKLDLGTRCLEKLENLQKLDLSHSDIEASDCCNLQLKNLRHLQYLNLSYNEPLGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQNLHLLRVLNLSHCLLDTSNQHLLAGLQDLRHLNLQGNSFQDGSISKTNLLQMVGSLEILILSSCNLLSIDQQAFHGLRNVNHLDLSHNSLTGDSMDALSHLKGLYLNMASNNIRIIPPHLLPALSQQSIINLSHNPLDCTCSNIHFITWYKENLHKLEDSEETTCANPPSLRGVKLSDVKLHCGITGVGIFFIVVFVFLLILLLIFSVKFILRWKYQHI", "length": 661, "header": "tr|F1MFI2-1|F1MFI2_BOVIN Isoform 1 of CD180 antigen OS=Bos taurus OX=9913 GN=CD180 PE=3 SV=1 CANONICAL=F1MFI2-1" }, "locus": { "chromosome": "20", "start_pos": 12432351, "end_pos": 12418066, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008348.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008348.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008348.5", "url": "https://www.ensembl.org/id/ENSBTAP00000008348.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-166016", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-166016", "resource": "Reactome", "description": "Toll Like Receptor 4 (TLR4) Cascade" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MNQ4-1", "protein_name": "CD180 antigen", "gene_name": "Cd180", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAPAISCVFLVALFSTSCEAIASSDQMCIEKETNKTYNCENLGLGEIPGTLPNSTECLEFSFNFLPTIQNTTFSRLVNLTFLDLTRCQIYWIHEDTFQSQHQLDTLVLTANPLIFMAETSLNGPKSLKHLFFIQTGMSSLDFIPMHNLKNLESLHLGSNHISSIKLPKDFPTEKLKVLDFQNNAIHYLSKEDVGSLQQATNLSLNLKGNDITRIELGAFKSTIFQSLDFGGTLDLLVIFKGLQNSTVQSLWLGTFEDINDEDINFSVFDGLCEMSVESMYLQKHHFFNISSNTFHCFTSLQELDLTATHLKELPSGIVGLKSLKKLVLSANKFSNLCQINAANFPSLTHLYIKGNTKRLDLGTGCLENLENLHLLDLSHDDIETSDCCNLQLKNLSHLQSLNLSYNEPLGLKTEAFQECPQLELLDLAFTRLRVNTAQSPFQNLHLLKVLNLSHCLLDTSNQHILDGLPVLQHLNLQGNNFPNGNIQKTNPLQTLESLEILILSFCDLSSIDQQAFISLKIMNHVDLSHNRLTSSSIEALSHLKGIYLNLAANHIGIIPSGLLPILSQQRTINLRGNPLDCTCSNIYFLEWYKENMQKLEDTENTFCANPPLLRGVKLSDVTLSCSITAVGIFFLIVFLLLFTVVLIFAVKYFLRWKYQHI", "length": 661 }, "evidence": [ { "id": "F1MFI2", "url": "https://omabrowser.org/oma/group/F1MFI2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0Y967-1", "protein_name": "CD180 antigen", "gene_name": "CD180", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVRSSCLMIAAALACASCRATRIVDATCTEITANKSYTCEGLGLREIPGSLPVTTEILDFSFNVLPSLQNSTFSGLVSLLYLDLTRCQINWVYEDAFHNNRRLQTIVLTGNLLMFLSDTAFAGPQSLRELVLTQTGISTISFIPMTNLDMLDTLILGSNHISSLQFPPNFPTKNLKHLDFQMNHIRVITAEDVSILQKTSNMTLIFKGNDILHIEPGAFQSYFYSLDFGGCADIPGVLAGIRNSTTQTLWLGTFSDVEKKTDITPGVLEGLCNISVKDLYLQLRHFENLNAATFHCLTRLRKLDLTHTHISALPPGISGMSSLRELVLSINSFQHLCNVSSASFPSLTHLHIKGNLQALQLGSGCLEGLAELRYLDLSHSHVESLDCCSKALNGLSSLQYLNLSHNTKLHIQDLFFKEGASLELLDIAFTRLHIATLQGPFRNLRRLQVLNVSSSYVNTSIQHLFQGLENLVLLDLSQNTFESGIMLEDKLFRQLSNLEVLILSSCELTAVDNQAFHSLGKLRHVDLSHNKFTALSTDAFSKLKTIYLNFAYNKIRTVPRDQLDSLPGHSVINLSYNPLECTCSNVGFITWYRQNLDKIEDPEGTTCSEPKSLAGAPLATVTLSCGISTAGIIAVVLVVLCCVAISIWAARYFKQNYQPI", "length": 660 }, "evidence": [ { "id": "F1MFI2", "url": "https://omabrowser.org/oma/group/F1MFI2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LDN3-1", "protein_name": "CD180 antigen", "gene_name": "Cd180", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALDISCFLLVALFSASCQAIGSSDQRCTEKEVNKTYNCEHLGLSEIPGTLPNSTESLEFSFNALPTIQKTTFSRLVNLTFLDLTRCQIYWIHEDTFQSQHRLETLVLTANPLIFMAETALTGPKALKHLFFIQTGISSIEFIPVHSQKALESLYLGSNHISSIRLPKDFPTEKLKVLDFQNNAIHHLSKEDVSSLQQATNLSLNLNGNDITGIEPGAFKSTVFQSLNFGGTQSLLVIFKGLQNSTIQSLWLGTFEDIDDDEDISSSMFEGLCEMSVERINLQKHHFFNITSNTFYCFSGLQELDLTATHLTELPSGIVGLSKLKKLVLSANKFENLCQISASNFPSLTHLYIKGNTKRLELGSGCLETLEHLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLGLRTEAFKECPQLELLDLAFTRLHVKDAQSPFQNLHLLKVLNLSHCLLGSSNQHLLDGLPALRHLNLQGNRFPNGNIQKTNPLQALGSLEILILSFCDLSSIDHQAFINLKIMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIIPPSLLPVLSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDIEDTFCANPPLLRGVKVSDVMLSCSMAAVGIFFLIVFLLLFAVLLIFAVKRFLRWKYQHI", "length": 662 }, "evidence": [ { "id": "F1MFI2", "url": "https://omabrowser.org/oma/group/F1MFI2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q62192-1", "protein_name": "CD180 antigen", "gene_name": "Cd180", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPDISCFFLVALFLASCRATTSSDQKCIEKEVNKTYNCENLGLNEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIYWIHEDTFQSQHRLDTLVLTANPLIFMAETALSGPKALKHLFFIQTGISSIDFIPLHNQKTLESLYLGSNHISSIKLPKGFPTEKLKVLDFQNNAIHYLSKEDMSSLQQATNLSLNLNGNDIAGIELGAFDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGLCEMSVESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLELGTGCLENLENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCENPPLLRGVRLSDVTLSCSMAAVGIFFLIVFLLVFAILLIFAVKYFLRWKYQHI", "length": 661 }, "evidence": [ { "id": "F1MFI2", "url": "https://omabrowser.org/oma/group/F1MFI2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q99467-1", "protein_name": "CD180 antigen", "gene_name": "CD180", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAFDVSCFFWVVLFSAGCKVITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKLSCGITAIGIFFLIVFLLLLAILLFFAVKYLLRWKYQHI", "length": 661 }, "evidence": [ { "id": "F1MFI2", "url": "https://omabrowser.org/oma/group/F1MFI2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MFI2", "url": "https://www.uniprot.org/uniprotkb/F1MFI2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "F1MFI2", "url": "https://www.uniprot.org/uniprotkb/F1MFI2" } ], "pmid": "" }, { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "F1MFI2", "url": "https://www.uniprot.org/uniprotkb/F1MFI2" } ], "pmid": "" }, { "name": "cellular response to lipopolysaccharide", "id": "GO:0071222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "database": "UniProtKB", "id": "F1MFI2", "url": "https://www.uniprot.org/uniprotkb/F1MFI2" } ], "pmid": "" }, { "name": "B cell proliferation involved in immune response", "id": "GO:0002322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002322", "evidence": [ { "database": "UniProtKB", "id": "F1MFI2", "url": "https://www.uniprot.org/uniprotkb/F1MFI2" } ], "pmid": "" }, { "name": "positive regulation of lipopolysaccharide-mediated signaling pathway", "id": "GO:0031666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031666", "evidence": [ { "database": "UniProtKB", "id": "F1MFI2", "url": "https://www.uniprot.org/uniprotkb/F1MFI2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "lipopolysaccharide immune receptor activity", "id": "GO:0001875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001875", "evidence": [ { "database": "UniProtKB", "id": "F1MFI2", "url": "https://www.uniprot.org/uniprotkb/F1MFI2" } ], "pmid": "" }, { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "F1MFI2", "url": "https://www.uniprot.org/uniprotkb/F1MFI2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 201, "end_pos": 203, "annotation": "n_glycosylation_sequon" }, { "start_pos": 244, "end_pos": 246, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" }, { "start_pos": 573, "end_pos": 575, "annotation": "n_glycosylation_sequon" }, { "start_pos": 70, "end_pos": 72, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MFI2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 661, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MFI2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MFI2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFI2" }, { "id": "SM00082", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00082" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRRCT", "eco_id": "ECO_0000259", "start_pos": 577, "end_pos": 626, "start_aa": "Asn", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 201, "end_pos": 203 }, { "start_pos": 244, "end_pos": 246 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 402, "end_pos": 404 }, { "start_pos": 451, "end_pos": 453 }, { "start_pos": 53, "end_pos": 55 }, { "start_pos": 573, "end_pos": 575 }, { "start_pos": 70, "end_pos": 72 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { 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"pathway": [ { "id": "bta:538985", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538985", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D1QF18-1", "protein_name": "Fer3 like bHLH transcription factor", "gene_name": "FERD3L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAYPQSCVDATVLDFVADLSLASPGHPLLCDFAPGVPYADHQDLVLQEGRARSLPRFEEEDPEEEGEVEEGEDEEVEEAGRGASLLGRPKRKRVITYAQRQAANIRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLESFEKKETG", "length": 164 }, "evidence": [ { "id": "F1MFN4", "url": "https://omabrowser.org/oma/group/F1MFN4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XRA2-1", "protein_name": "Fer3 like bHLH transcription factor", "gene_name": "FERD3L", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAGLFPAHRRPELLRGTAPPLPCPERLLGASVLGFVADISLGAPQSSSRAGPSLGLTSEPPFGDRTLSLREGMARGLPLAAFGDGDLEDEEEEEEEERMRSASLLDRPRRKRVITYAQRQAANIRERKRMFNLNEAFDQLRKKVPTFAYEKRLSRIETLRLAIVYISFMTELLNGCSRQEAS", "length": 183 }, "evidence": [ { "id": "F1MFN4", "url": "https://omabrowser.org/oma/group/F1MFN4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A114-1", "protein_name": "Fer3-like bHLH transcription factor", "gene_name": "Ferd3l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAYPESCLDANVLNFVADLSLASPRHPFLCEFPPGVPFEDQTLGFREGRGLLQFEGRYQEVEGGEVDYEDPEEEEEEGEGRGRVASLLGRPKRKRVITYAQRQAANIRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLQSKEEKEAS", "length": 166 }, "evidence": [ { "id": "F1MFN4", "url": "https://omabrowser.org/oma/group/F1MFN4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HD65-1", "protein_name": "Fer3-like protein", "gene_name": "Ferd3l", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MATYPESYLDSTMLNFVADLSLASPRHPLLCDFPPGVPLGDQTLGFRERRPRGLSQFEETDQEDEGSEVIYEDREEEEEEGMGRERVASLLGRPKRKRVITYAQRQAANIRERKRMFNLNEAFDRLRRKVPTFAYEKRLSRIETLRLAIIYISFMTELLQSSEKKETG", "length": 168 }, "evidence": [ { "id": "F1MFN4", "url": "https://omabrowser.org/oma/group/F1MFN4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q923Z4-1", "protein_name": "Fer3-like protein", "gene_name": "Ferd3l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAYPESCLDATVLNFVADLSLASPRHPLLCEFPPGVPFGDRTLGYREGRPGRLSQFDERYQEVEGDEVEYEDPEEEEEEGEGRGRVASLLGRPKRKRVITYAQRQAANIRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLQSKEEKEAS", "length": 168 }, "evidence": [ { "id": "F1MFN4", "url": "https://omabrowser.org/oma/group/F1MFN4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96RJ6-1", 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"id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "F1MFN4", "url": "https://www.uniprot.org/uniprotkb/F1MFN4" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "F1MFN4", "url": "https://www.uniprot.org/uniprotkb/F1MFN4" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1MFN4", "url": "https://www.uniprot.org/uniprotkb/F1MFN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MFN4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 164, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MFN4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MFN4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFN4" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 100, "end_pos": 152, "start_aa": "Ala", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MFQ8-1", "uniprot_ac": "F1MFQ8", "uniprot_id": "F1MFQ8_BOVIN", "mass": { "chemical_mass": 34911.0, "monoisotopic_mass": 34911.0 }, "refseq": { "ac": "NP_001376923", "name": "olfactory receptor family 6 subfamily N member 1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376923" }, "gene_names": [ { "name": "OR6N1", "type": "recommended", "evidence": [ { "id": "F1MFQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFQ8" } ] }, { "name": "OR6N1", "type": "synonym", "evidence": [ { "id": "NP_001376923", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376923" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1MFQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFQ8/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 6 subfamily N member 1", "type": "synonym", "evidence": [ { "id": "NP_001376923", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376923" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376923" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MFQ8", "url": "https://www.uniprot.org/uniprotkb/F1MFQ8#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFQ8", "url": "https://www.uniprot.org/uniprotkb/F1MFQ8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR6N1", "url": "https://www.uniprot.org/uniprotkb/F1MFQ8", "locus": { "chromosome": "3", "start_pos": 10908358, "end_pos": 10907420, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034601", "url": "https://www.ensembl.org/id/ENSBTAG00000034601" } ] } } ], "crossref": [ { "id": "F1MFQ8", "url": "https://alphafold.ebi.ac.uk/entry/F1MFQ8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034601", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034601", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15914", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15914", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517209", "url": "https://www.ncbi.nlm.nih.gov/gene/517209", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050939", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050939", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517209", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517209", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HTPMYQF", "url": "https://omabrowser.org/oma/group/HTPMYQF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MFQ8", "url": "https://www.orthodb.org/?gene=F1MFQ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24242", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24242", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24242:SF369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24242:SF369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376923", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MFQ8", "url": "https://www.uniprot.org/uniprotkb/F1MFQ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFQ8-1", "url": "https://www.uniprot.org/uniprotkb/F1MFQ8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPGNWSQVTEFIILGFPHLQGVQAFLFLLLLLIYLTTVLGNLLIFLVVCLDFRLHTPMYLLVSILSLLELGYTAATTPKMLSNLLSEKKTISFSGCLLQIYFFHSLGATECYLLTAMAYDRYLAICQPLHYPTRMTPALCVKIAVGCWLGGLAGPVAEISLVSHLPFCGPNRIQHIFCDFPPVLSLACTDTSINVLVDFVINSCKILANFLLILSSYVQIICTVLRIPSAAGKKKAFSTCASHLTVVLIFYGSILFMYVRLKKSYSLDYDRALAVVYSVLTPFLNPFIYSLHNKEIKEAVRRQLKRMGILE", "length": 312, "header": "tr|F1MFQ8-1|F1MFQ8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6N1 PE=3 SV=2 CANONICAL=F1MFQ8-1" }, "isoforms": [ { "isoform_ac": "F1MFQ8-1", "url": "https://www.uniprot.org/uniprotkb/F1MFQ8/entry", "sequence": { "sequence": "MKPGNWSQVTEFIILGFPHLQGVQAFLFLLLLLIYLTTVLGNLLIFLVVCLDFRLHTPMYLLVSILSLLELGYTAATTPKMLSNLLSEKKTISFSGCLLQIYFFHSLGATECYLLTAMAYDRYLAICQPLHYPTRMTPALCVKIAVGCWLGGLAGPVAEISLVSHLPFCGPNRIQHIFCDFPPVLSLACTDTSINVLVDFVINSCKILANFLLILSSYVQIICTVLRIPSAAGKKKAFSTCASHLTVVLIFYGSILFMYVRLKKSYSLDYDRALAVVYSVLTPFLNPFIYSLHNKEIKEAVRRQLKRMGILE", "length": 312, "header": "tr|F1MFQ8-1|F1MFQ8_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR6N1 PE=3 SV=2 CANONICAL=F1MFQ8-1" }, "locus": { "chromosome": "3", "start_pos": 10908355, "end_pos": 10907420, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027797.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027797.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027797.5", "url": "https://www.ensembl.org/id/ENSBTAP00000027797.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517209", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517209", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A926-1", "protein_name": "Olfactory receptor", "gene_name": "Or6n1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTGNWSQVTEFIILGFPYFQGVQTYLFVLLLSIYLTTILGNLLIFLVVYLDSRLHTPMYKFVSILSFLELGYTAATIPKMLANLLSEKKTISFSGCLLQIYFFHSLGATECYLLTAMAYDRYLAICRPLHYPTLMTQTLCAKIATGCWLGGLAGPVVEISLVSRLPFCGPNHIQHIFCDFPPVLSLACTDTSVNVLVDFIINSCKILATFLLILSSYLQIIRTVLKIPSAAGKKKAFSTCASHLTVVLIFYGSILFMYVRLKKSYSLDYDRALAVVYSVVTPFLNPFIYSLRNKEIKEALKRQLMRTGMLG", "length": 312 }, "evidence": [ { "id": "F1MFQ8", "url": "https://omabrowser.org/oma/group/F1MFQ8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3H815-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100751548", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "METGNWSKVTEFIILGFPHLQGVQTYLFFLLLAIYLTTILGNLLIFLVVHMDSRLHTPMYKFVSILSILELGYTAATIPKMLANLLSEKKTISFSGCLLQIYFFHSLGATECYLLTAMAYDRYLAICKPLHYPTLMTQTLCTKIAIGCWLGGLAGPVVEISLVSRLPFCGPNHIQHIFCDFPPVLSLACTDTSVNVLVDFIVNSCKILATFLLILSSYLQIIRTVLRIPSAAGKKKAFSTCASHLTVVLIFYGSILFMYVRLKKSYSLDYDRALAVVYSVVTPFLNPFIYSLRNKEIKEALKRQLMRAGMLA", "length": 312 }, "evidence": [ { "id": "F1MFQ8", "url": "https://omabrowser.org/oma/group/F1MFQ8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q7TRW1-1", "protein_name": "Olfactory receptor", "gene_name": "Or6n1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGTGNWSQVIEFIILGFPHFQGVQIYLFFLLLSIYFTTILGNLLIFLVVYLDSRLHTPMYRFVSILSFLELGYTAATIPKMLANLLSEKKTISFSGCLLQIYFFHSLGATECYLLTAMAYDRYLAICRPLHYPTLMTQSLCIKIAIGCWLGGLAGPVVEISLVSRLPFCGPNHIQHIFCDFPPVLSLACTDTSVNVLVDFIINSCKILATFLLILSSYLQIIRTVLKIPSAAGKKKAFSTCASHLTVVLIFYGSILFMYVRLKKSYSLDYDRALAVVYSVITPFLNPFIYSLRNKEIKEALKRQLMRTGILR", "length": 312 }, "evidence": [ { "id": "F1MFQ8", "url": "https://omabrowser.org/oma/group/F1MFQ8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NGY5-1", "protein_name": "Olfactory receptor 6N1", "gene_name": "OR6N1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDTGNWSQVAEFIILGFPHLQGVQIYLFLLLLLIYLMTVLGNLLIFLVVCLDSRLHTPMYHFVSILSFSELGYTAATIPKMLANLLSEKKTISFSGCLLQIYFFHSLGATECYLLTAMAYDRYLAICRPLHYPTLMTPTLCAEIAIGCWLGGLAGPVVEISLISRLPFCGPNRIQHVFCDFPPVLSLACTDTSINVLVDFVINSCKILATFLLILCSYVQIICTVLRIPSAAGKRKAISTCASHFTVVLIFYGSILSMYVQLKKSYSLDYDQALAVVYSVLTPFLNPFIYSLRNKEIKEAVRRQLKRIGILA", "length": 312 }, "evidence": [ { "id": "F1MFQ8", "url": "https://omabrowser.org/oma/group/F1MFQ8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MFQ8", "url": "https://www.uniprot.org/uniprotkb/F1MFQ8" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1MFQ8", "url": "https://www.uniprot.org/uniprotkb/F1MFQ8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MFQ8", "url": "https://www.uniprot.org/uniprotkb/F1MFQ8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "F1MFQ8", "url": "https://www.uniprot.org/uniprotkb/F1MFQ8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MFQ8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 312, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MFQ8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MFQ8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MFQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFQ8" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MFR1-1", "uniprot_ac": "F1MFR1", "uniprot_id": "F1MFR1_BOVIN", "mass": { "chemical_mass": 169559.0, "monoisotopic_mass": 169559.0 }, "refseq": {}, "gene_names": [ { "name": "HFM1", "type": "recommended", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ], "protein_names": [ { "name": "Probable ATP-dependent DNA helicase HFM1", "type": "recommended", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1/entry#names_and_taxonomy" } ] }, { "name": "5.6.2.4", "type": "synonym", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1/entry#names_and_taxonomy" } ] }, { "name": "DNA 3'-5' helicase HFM1", "type": "synonym", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for crossover formation and complete synapsis of homologous chromosomes during meiosis.", "evidence": [ { "database": "UniProtKB", "id": "F1MFR1", "url": "https://www.uniprot.org/uniprotkb/F1MFR1#function" }, { "database": "UniProtKB", "id": "ARBA00059912", "url": "https://www.uniprot.org/uniprotkb/ARBA00059912#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MFR1", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HFM1", "url": "https://www.uniprot.org/uniprotkb/F1MFR1", "locus": { "chromosome": "3", "start_pos": 52089534, "end_pos": 51979806, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020856", "url": "https://www.ensembl.org/id/ENSBTAG00000020856" } ] } } ], "crossref": [ { "id": "ENSBTAG00000020856", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020856", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18023", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18023", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18795", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18795", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MFR1", "url": "https://www.orthodb.org/?gene=F1MFR1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47835", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47835", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47835:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47835:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02889", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02889", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23445", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23445", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MFR1", "url": "https://www.uniprot.org/uniprotkb/F1MFR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFR1-1", "url": "https://www.uniprot.org/uniprotkb/F1MFR1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRFSRQEHWSGLPFPPPGNLLYPRIEPESLVSPALAGGFFIIAPPGKPRFFQIYEKVQLLTMLESNDSVFSLDNLFFEKTDEAENHLDSEISMDWFLPPAPLISEIPDTQALEEEIENHQLLGQNKKSKMLPSNLKITNEDINYVLQTQKFQFDFPSNEYEEDDLNLGGAGNNDLHVAGKLTCGSSQKWKNHIGTEIELEKNVPDDTKLVNSAQDKGVSMSAFRKRLFKISDNIHEDGYSNDSANLDSNTGSVKIVQTEVNKGKSWKDSNSKQKPQYSDCNILTATDTLFASEIREGIIKAPLFPVASQPHTVQGVTEKSLDSLKAVTEIPAKFRSIFKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWSNIKIVYMAPIKALCSQRFDDWKKKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVHLVRLFLIDEVHVVKDENRGPTLEVVVSRMKTVQILSPAVENTNSIIPMRFVAVSATIPNAEDIAEWLSDGERSAVCLKMDERHRPVKLRKVVLGFPSSDNQTEFKFDLTLNYKIASIIQTYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKCAYSIKDSKLRDILIHGVAYHHAGMELSDRKVVEGAFTVGDIPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGMFEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTKEKYIQMLACSDTIESSLHRHLIEHLNAEIVLHTITNVNIALEWIRSTLLYIRALKNPSHYGFASGLNKDGIESKLQELCLKNLNDLSSLNLIKMDEDINFKPTEAGRLMAWYYITFETVKKFCTMSGKETLSDLVTMIASCKEFLDVQLRINEKKALNTLNKDPNRTTIRFPMEGRIKTREMKVNCLIQAQLGCIPVQDFALTQDTAKIFRNGSRITRWLSDFVATQEKFAVLLNSLILAKCFRCKLWENSPHVSKQLEKIGITLSNAMVNAGLTSFKKIEETDARELELILNRHPPFGTQIKETVMYLPKYELEVEQITRYSDTMAEILVTVILRNFEQLQTKRTASNSHYVTLIIGDADNQLVFKHKIMDSVLLKAGNWAKKFDVRRALKSENLSINLISSEYVGLDIQRKFTVFYSGPKRFGNQIIIQKKSETEISHSEHSDRSTVAGPKKGMTACKKPGNRECNHHCKNKHTCGHDCCKTGVAQKSEGKESTISSYLSDLRNRNAVSSLPPVKRLKMQMNKSPSVDLKDFGFAPKPSLPSIARSEYLNTPELPIMEQRDQHEIYTKSQQQPSAYQDKEVLKVNFELGNEIWDDFDDENLVEITSFSAETEKTKTSGFGNTLSSSTGESKLPFQESKGQFQRESSKSFVSSHEKPDIYLSNSAVSKFGASSMTQLPQQSGNASIVHLQERKQQSLSPEIEKLCFTRSEKISNSSNFNEKVDCFIRNECKKEIDFSRYHPDDEADEIKSFLGIFDGIF", "length": 1498, "header": "tr|F1MFR1-1|F1MFR1_BOVIN Isoform 1 of Probable ATP-dependent DNA helicase HFM1 OS=Bos taurus OX=9913 GN=HFM1 PE=3 SV=4 CANONICAL=F1MFR1-1" }, "isoforms": [ { "isoform_ac": "F1MFR1-1", "url": "https://www.uniprot.org/uniprotkb/F1MFR1/entry", "sequence": { "sequence": "MRFSRQEHWSGLPFPPPGNLLYPRIEPESLVSPALAGGFFIIAPPGKPRFFQIYEKVQLLTMLESNDSVFSLDNLFFEKTDEAENHLDSEISMDWFLPPAPLISEIPDTQALEEEIENHQLLGQNKKSKMLPSNLKITNEDINYVLQTQKFQFDFPSNEYEEDDLNLGGAGNNDLHVAGKLTCGSSQKWKNHIGTEIELEKNVPDDTKLVNSAQDKGVSMSAFRKRLFKISDNIHEDGYSNDSANLDSNTGSVKIVQTEVNKGKSWKDSNSKQKPQYSDCNILTATDTLFASEIREGIIKAPLFPVASQPHTVQGVTEKSLDSLKAVTEIPAKFRSIFKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWSNIKIVYMAPIKALCSQRFDDWKKKFGPIGLNCKELTGDTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVHLVRLFLIDEVHVVKDENRGPTLEVVVSRMKTVQILSPAVENTNSIIPMRFVAVSATIPNAEDIAEWLSDGERSAVCLKMDERHRPVKLRKVVLGFPSSDNQTEFKFDLTLNYKIASIIQTYSDQKPTLVFCATRKGVQQAASVLVKDAKFIMTVEQKQRLQKCAYSIKDSKLRDILIHGVAYHHAGMELSDRKVVEGAFTVGDIPVLFTTSTLAMGVNLPAHLVVIKSTMHYAGGMFEEYSETDILQMIGRAGRPQFDTTATAVIMTRLSTKEKYIQMLACSDTIESSLHRHLIEHLNAEIVLHTITNVNIALEWIRSTLLYIRALKNPSHYGFASGLNKDGIESKLQELCLKNLNDLSSLNLIKMDEDINFKPTEAGRLMAWYYITFETVKKFCTMSGKETLSDLVTMIASCKEFLDVQLRINEKKALNTLNKDPNRTTIRFPMEGRIKTREMKVNCLIQAQLGCIPVQDFALTQDTAKIFRNGSRITRWLSDFVATQEKFAVLLNSLILAKCFRCKLWENSPHVSKQLEKIGITLSNAMVNAGLTSFKKIEETDARELELILNRHPPFGTQIKETVMYLPKYELEVEQITRYSDTMAEILVTVILRNFEQLQTKRTASNSHYVTLIIGDADNQLVFKHKIMDSVLLKAGNWAKKFDVRRALKSENLSINLISSEYVGLDIQRKFTVFYSGPKRFGNQIIIQKKSETEISHSEHSDRSTVAGPKKGMTACKKPGNRECNHHCKNKHTCGHDCCKTGVAQKSEGKESTISSYLSDLRNRNAVSSLPPVKRLKMQMNKSPSVDLKDFGFAPKPSLPSIARSEYLNTPELPIMEQRDQHEIYTKSQQQPSAYQDKEVLKVNFELGNEIWDDFDDENLVEITSFSAETEKTKTSGFGNTLSSSTGESKLPFQESKGQFQRESSKSFVSSHEKPDIYLSNSAVSKFGASSMTQLPQQSGNASIVHLQERKQQSLSPEIEKLCFTRSEKISNSSNFNEKVDCFIRNECKKEIDFSRYHPDDEADEIKSFLGIFDGIF", 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{ "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LSH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSH0" } ] } ] }, { "uniprot_ac": "A0A3Q1LT80", "gene_name": "FANCM", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LT80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT80" } ] } ] }, { "uniprot_ac": "A0A3Q1LTL4", "gene_name": "TDRD9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LTL4", "database": "UniProtKB", "url": 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] } ] }, { "uniprot_ac": "A0A3Q1M493", "gene_name": "POLQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "A0A3Q1M493", "database": 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} ] } ] }, { "uniprot_ac": "A0A3Q1M7R9", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1M7R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7R9" } ] } ] }, { "uniprot_ac": "A0A3Q1MDD8", "gene_name": "ENTPD3", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0A3Q1MDD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDD8" } ] } ] }, { "uniprot_ac": "A0A3Q1MR04", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0A3Q1MR04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR04" } ] } ] }, { "uniprot_ac": "A0A3Q1MR43", "gene_name": "DDX46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MR43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MR43" } ] } ] }, { "uniprot_ac": "A0A3Q1MS44", "gene_name": "DDX51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS44" } ] } ] }, { "uniprot_ac": "A0A3Q1MU57", "gene_name": "DDX54", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1MU57", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MU57" } ] } ] }, { "uniprot_ac": "A0A3Q1NMG4", "gene_name": "DDX59", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1NMG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NMG4" } ] } ] }, { "uniprot_ac": "A0AAA9RRF7", "gene_name": "DDX31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9RRF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RRF7" } ] } ] }, { "uniprot_ac": "A0AAA9RUK3", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9RUK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUK3" } ] } ] }, { "uniprot_ac": "A0AAA9RXI8", "gene_name": "SPATA5", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "A0AAA9RXI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI8" } ] } ] }, { "uniprot_ac": "A0AAA9RXM7", "gene_name": "HLTF", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXM7" } ] } ] }, { "uniprot_ac": "A0AAA9S5G9", "gene_name": "RECQL", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5G9" } ] } ] }, { "uniprot_ac": "A0AAA9S7V9", "gene_name": "RECQL4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAA9S7V9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7V9" } ] } ] }, { "uniprot_ac": "A0AAA9SPF3", "gene_name": "IFIH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9SX42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX42" } ] } ] }, { "uniprot_ac": "A0AAA9T2L7", "gene_name": "DDX11", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T2L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2L7" } ] } ] }, { "uniprot_ac": "A0AAA9T674", "gene_name": "DDX56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9T674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T674" } ] } ] }, { "uniprot_ac": "A0AAA9T8W7", "gene_name": "PIF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0AAA9T8W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8W7" } ] } ] }, { "uniprot_ac": "A0AAA9TGZ3", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9TGZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TGZ3" } ] } ] }, { "uniprot_ac": "A0AAA9TT27", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT27" } ] } ] }, { "uniprot_ac": "A0AAA9TT64", "gene_name": "DNA2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLQ5" } ] } ] }, { "uniprot_ac": "A0AAF6DLT1", "gene_name": "SUPV3L1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6DLT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLT1" } ] } ] }, { "uniprot_ac": "A0AAF6YME1", "gene_name": "RHOT2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0AAF6YME1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YME1" } ] } ] }, { "uniprot_ac": "A0AAF6YVB0", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAF6YVB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YVB0" } ] } ] }, { "uniprot_ac": "A0AAF6Z0E4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "A0AAF6Z0E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0E4" } ] } ] }, { "uniprot_ac": "A0AAF6Z0U5", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z0U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0U5" } ] } ] }, { "uniprot_ac": "A0AAF6Z733", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAF6Z733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z733" } ] } ] }, { "uniprot_ac": "A0ABI0NSA6", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NSA6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSA6" } ] } ] }, { "uniprot_ac": "A0ABI0NX25", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NX25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NX25" } ] } ] }, { "uniprot_ac": "A0ABI0NXS3", "gene_name": "DDX42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0NXS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXS3" } ] } ] }, { "uniprot_ac": "A0ABI0P204", "gene_name": "LOC112446470", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P204", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P204" } ] } ] }, { "uniprot_ac": "A0ABI0P3F2", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3F2" } ] } ] }, { "uniprot_ac": "A0ABI0P467", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0ABI0P467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P467" } ] } ] }, { "uniprot_ac": "A0JND9", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "A0JND9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JND9" } ] } ] }, { "uniprot_ac": "A1A4H6", "gene_name": "DDX27", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1A4H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4H6" } ] } ] }, { "uniprot_ac": "A4FUD9", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A4FUD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4FUD9" } ] } ] }, { "uniprot_ac": "A4K436", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "A4K436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4K436" } ] } ] }, { "uniprot_ac": "A5D7C1", "gene_name": "DDX52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A5D7C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7C1" } ] } ] }, { "uniprot_ac": "A5PJA1", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A5PJA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJA1" } ] } ] }, { "uniprot_ac": "A5PJI5", "gene_name": "GET3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": 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"activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": 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{ "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", 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"start_pos": 45015353, "end_pos": 45021308, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011889", "url": "https://www.ensembl.org/id/ENSBTAG00000011889" } ] } } ], "crossref": [ { "id": "F1MFW8", "url": "https://alphafold.ebi.ac.uk/entry/F1MFW8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011889", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011889", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR005612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027193", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027193", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12455", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12455", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12455:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12455:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03914", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03914", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26702", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26702", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MFW8", "url": "https://www.uniprot.org/uniprotkb/F1MFW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MFW8-1", "url": "https://www.uniprot.org/uniprotkb/F1MFW8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTAGTGRDVSGAPGGGATGLVCPAWGGGMEGDAGPGDARRALGHLVEAVLASRGEANAVFDILAVLQGYPANTGISPQSEDQEEIQEAVHACSRLFGALLARGELFVGQLPSEEMVLTGSRGATRKYKIWMRHRYQSCCNRLGELLAHPSFQVKELALSTLMKFVQLEGEHPLEKPKWEGNYLFPHQLFMLVVGGLLSPEEDRSLLLSQFREYLEHDDIRYHTMQAASNTVARTTDGRPEVPLTFWNNAFMLLSSVSLPRQESTLSSFYVKHTELSDKWKVVHLKEHRKAFQQMWLHFLKHQLPLRVCKKVLVIMHDSILPHLAQPSLMIDFLTRAYDIGGAVSLLALNGLFILIHKHNLEYPDFYRKLYGLLDPSVFHVKYRARFFHLADLFLSSSHLPAYLVAAFTKRLARLALTAPPEALLMVLPFICNLLRRHPACRVLMHRPRGPELDADPYDPTEEDPAQSRALESSLWELQALQQHYHPEVSKAASAINQALSVPEVSIAPLLEVTAFEIFERDLKKKGPGSVPLEFIPARGLLGRREDLCAQHFTLS", "length": 555, "header": "tr|F1MFW8-1|F1MFW8_BOVIN Isoform 1 of Nucleolar complex associated 4 homolog OS=Bos taurus OX=9913 GN=NOC4L PE=3 SV=4 CANONICAL=F1MFW8-1" }, "isoforms": [ { "isoform_ac": "F1MFW8-1", "url": "https://www.uniprot.org/uniprotkb/F1MFW8/entry", "sequence": { "sequence": "MTAGTGRDVSGAPGGGATGLVCPAWGGGMEGDAGPGDARRALGHLVEAVLASRGEANAVFDILAVLQGYPANTGISPQSEDQEEIQEAVHACSRLFGALLARGELFVGQLPSEEMVLTGSRGATRKYKIWMRHRYQSCCNRLGELLAHPSFQVKELALSTLMKFVQLEGEHPLEKPKWEGNYLFPHQLFMLVVGGLLSPEEDRSLLLSQFREYLEHDDIRYHTMQAASNTVARTTDGRPEVPLTFWNNAFMLLSSVSLPRQESTLSSFYVKHTELSDKWKVVHLKEHRKAFQQMWLHFLKHQLPLRVCKKVLVIMHDSILPHLAQPSLMIDFLTRAYDIGGAVSLLALNGLFILIHKHNLEYPDFYRKLYGLLDPSVFHVKYRARFFHLADLFLSSSHLPAYLVAAFTKRLARLALTAPPEALLMVLPFICNLLRRHPACRVLMHRPRGPELDADPYDPTEEDPAQSRALESSLWELQALQQHYHPEVSKAASAINQALSVPEVSIAPLLEVTAFEIFERDLKKKGPGSVPLEFIPARGLLGRREDLCAQHFTLS", "length": 555, "header": "tr|F1MFW8-1|F1MFW8_BOVIN Isoform 1 of Nucleolar complex associated 4 homolog OS=Bos taurus OX=9913 GN=NOC4L PE=3 SV=4 CANONICAL=F1MFW8-1" }, "locus": { "chromosome": "17", "start_pos": 45021109, "end_pos": 45016357, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015774.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015774.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015774.7", "url": "https://www.ensembl.org/id/ENSBTAP00000015774.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1MFW8", "url": "https://www.uniprot.org/uniprotkb/F1MFW8" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "F1MFW8", "url": "https://www.uniprot.org/uniprotkb/F1MFW8" } ], "pmid": "" }, { "name": 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"PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15397:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15397:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09668", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09668", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24669", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24669", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MG01", "url": "https://www.uniprot.org/uniprotkb/F1MG01", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG01-1", "url": "https://www.uniprot.org/uniprotkb/F1MG01-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLTVYCVRRDLSEATFSLQVRPDFELHNFRVLCELESGIPAEETQIVYMERLLVNDHCSLGSYGLKDGDMVILLQKEAMRPRSPERAAGLCSMEPAGPALPGTSGSRPHQRAQSAQHSSRRGSGEKAGPGQGLDSPALVRSMLLSSPHDLSLLKERNPSLAEALLSGNLESFSQVLMEQQRERALREQERLRLFSADPFDLEAQAKIEEEIRQQNIEENMSIAMEEAPESFGQVAMLYINCRVNGHPLKAFVDSGAQMTIMNQVCAERCNIIRLVDRRWAGVAKGVGTQRILGRVHLAQIQIEGDFLQCSFSILEEQPMDMLLGLDMLRRHQCSIDLKRNVLVIGTTGTQTSFLPEGELPPCAKLVSGMGPEESSDKETANAIKHSVMDSGRKKH", "length": 396, "header": "tr|F1MG01-1|F1MG01_BOVIN Isoform 1 of DNA damage inducible 1 homolog 1 OS=Bos taurus OX=9913 GN=DDI1 PE=3 SV=2 CANONICAL=F1MG01-1" }, "isoforms": [ { "isoform_ac": "F1MG01-1", "url": "https://www.uniprot.org/uniprotkb/F1MG01/entry", "sequence": { "sequence": "MLLTVYCVRRDLSEATFSLQVRPDFELHNFRVLCELESGIPAEETQIVYMERLLVNDHCSLGSYGLKDGDMVILLQKEAMRPRSPERAAGLCSMEPAGPALPGTSGSRPHQRAQSAQHSSRRGSGEKAGPGQGLDSPALVRSMLLSSPHDLSLLKERNPSLAEALLSGNLESFSQVLMEQQRERALREQERLRLFSADPFDLEAQAKIEEEIRQQNIEENMSIAMEEAPESFGQVAMLYINCRVNGHPLKAFVDSGAQMTIMNQVCAERCNIIRLVDRRWAGVAKGVGTQRILGRVHLAQIQIEGDFLQCSFSILEEQPMDMLLGLDMLRRHQCSIDLKRNVLVIGTTGTQTSFLPEGELPPCAKLVSGMGPEESSDKETANAIKHSVMDSGRKKH", "length": 396, "header": "tr|F1MG01-1|F1MG01_BOVIN Isoform 1 of DNA damage inducible 1 homolog 1 OS=Bos taurus OX=9913 GN=DDI1 PE=3 SV=2 CANONICAL=F1MG01-1" }, "locus": { "chromosome": "15", "start_pos": 4391930, "end_pos": 4390743, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003750.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003750.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003750.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003750.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A061I6Z1-1", "protein_name": "Protein DDI1 homolog 1", "gene_name": "Ddi1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLITVYCVRRDLTEATFSLQVSPDFELCNFRVLCELESGVPAEEIQFVYMEQLLTDDHCSLGTYGLKDGDMVVLLQKDNVGLRTPGRTPNQPRADFTGSAIPGTSSTRHHHHQRQQRIPSTQAHGLASGENMAYARDLNSPALIRSMLLSNPHDLSLLKERNPALAEALLSGSLETFSQVLMEQQRERALREQEMVRLYSADPFDQEAQARIEEEIRQQNIEENMNIAMEEAPESFGQVAMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDQRWAGVAKGVGTQRIVGRVHLAQIQIEGDFLQCSFSILEEQPMDILLGLDMLRRHQCSIDLKKNVLVIGTTGTQTHFLPEGELPLCARLVSGTVQEDSSDKEVPGNIIKHPVKGPGRKQH", "length": 401 }, "evidence": [ { "id": "F1MG01", "url": "https://omabrowser.org/oma/group/F1MG01/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0JPP7-1", "protein_name": "Protein DDI1 homolog 1", "gene_name": "Ddi1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLITVYCVRRDLTEVTFSLQVNPDFELSNFRVLCELESGVPAEEAQIVYMEQLLTDDHCSLGSYGLKDGDMVVLLQKDNVGPRPPGRAPNHPRTDFTGSGSAVPGTSSSRHPHPHQHHHHQHQRIPSTQQAHGLASGENMAFAQDLNSPALIRSMLLSNPHDLSLLKERNPALAEALLSGNLETFSQVLVEQQRERAMREQEMFRLYSADPFDQETQARIEEEIRQQNIEENMNIAMEEAPESFGQVAMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIMGRVHLAQIQIEGDFLQCSFSILEEQPMDILLGLDMLRRHQCSIDLKKNVLVIGTTGSQTHFLPEGELPLCAKLLSGAVQEDSSDKEVAGSIKHPVKGPGRKKH", "length": 408 }, "evidence": [ { "id": "F1MG01", "url": "https://omabrowser.org/oma/group/F1MG01/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SV49-1", "protein_name": "DNA damage inducible 1 homolog 1", "gene_name": "DDI1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLLTVYCVRKDLSEATFSLQVSPDFELHNFRVLCELESGIPAEEIQIVYMERLLGDDHYSLGSYGLKDGDVVVLLQKENVGSRAPGRTSSLPQRDFPGTAVPGTSSSRHQHQHQHQRTQSVQQSRGMGSGEKMSSAQGLDSPALIRSMLLSNPHDLSLLKERNPALAEALLSGNLETFSQVLMEQQRERVLREQERFRLYSADPFDLEAQAKIEEEIRQQNIEENMNIAMEEAPESFGQVAMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIIRLVDRRWAGIAKGVGTQRIIGRVHLAQIQIEGDFLQCSFSILEEQPMDMLLGLDMLRRHQCSIDLKKNVLVIGTTGTQTYFLPEGELPPCAKLVSGTGQDESSDKEVADTIKHSVMNSGRKKH", "length": 401 }, "evidence": [ { "id": "F1MG01", "url": "https://omabrowser.org/oma/group/F1MG01/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8WTU0-1", "protein_name": "Protein DDI1 homolog 1", "gene_name": "DDI1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLITVYCVRRDLSEVTFSLQVSPDFELRNFKVLCEAESRVPVEEIQIIHMERLLIEDHCSLGSYGLKDGDIVVLLQKDNVGPRAPGRAPNQPRVDFSGIAVPGTSSSRPQHPGQQQQRTPAAQRSQGLASGEKVAGLQGLGSPALIRSMLLSNPHDLSLLKERNPPLAEALLSGSLETFSQVLMEQQREKALREQERLRLYTADPLDREAQAKIEEEIRQQNIEENMNIAIEEAPESFGQVTMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIIGRVHLAQIQIEGDFLQCSFSILEDQPMDMLLGLDMLRRHQCSIDLKKNVLVIGTTGTQTYFLPEGELPLCSRMVSGQDESSDKEITHSVMDSGRKEH", "length": 396 }, "evidence": [ { "id": "F1MG01", "url": "https://omabrowser.org/oma/group/F1MG01/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9DAF3-1", "protein_name": "Protein DDI1 homolog 1", "gene_name": "Ddi1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLITVYCVRRDLTEVTFSLQVNPDFELSNFRVLCELESGVPAEEAQIVYMEQLLTDDHCSLGSYGLKDGDMVVLLQKDNVGLRTPGRTPNHPRADFTGSGSAVPGTSSSRHPHQHQHHYHHHQRIPSTQQAHGLASGENMTFAQELDSPALIRSMLLSNPHDLSLLKERNPALAEALLSGNLETFSQVLMEQQRERTLREQEMFRLYSTNPFDQETQARIEEEIRQQNIEENMNIAMEEAPESFGQVAMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWGGVAKGVGTQRIMGRVHLAQIQIEGDFLQCSFSILEEQPMDILLGLDMLRRHQCSIDLKKNVLVIGTTGSQTHFLPEGELPLCAKLLSGTVQEESSDREVGGTIKHPVKGPGRKKH", "length": 408 }, "evidence": [ { "id": "F1MG01", "url": "https://omabrowser.org/oma/group/F1MG01/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MG01", "url": "https://www.uniprot.org/uniprotkb/F1MG01" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "F1MG01", "url": "https://www.uniprot.org/uniprotkb/F1MG01" } ], "pmid": "" }, { "name": "proteasomal protein catabolic process", "id": "GO:0010498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010498", "evidence": [ { "database": "UniProtKB", "id": "F1MG01", "url": "https://www.uniprot.org/uniprotkb/F1MG01" } ], "pmid": "" }, { "name": "regulation of DNA stability", "id": "GO:0097752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097752", "evidence": [ { "database": "UniProtKB", "id": "F1MG01", "url": "https://www.uniprot.org/uniprotkb/F1MG01" } ], "pmid": "" }, { "name": "cellular response to hydroxyurea", "id": "GO:0072711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072711", "evidence": [ { "database": "UniProtKB", "id": "F1MG01", "url": "https://www.uniprot.org/uniprotkb/F1MG01" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "aspartic-type endopeptidase activity", "id": "GO:0004190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004190", "evidence": [ { "database": "UniProtKB", "id": "F1MG01", "url": "https://www.uniprot.org/uniprotkb/F1MG01" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MG01-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 396, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MG01-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MG01" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG01" }, { "id": "PS50053", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50053" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ubiquitin-like", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 78, "start_aa": "Met", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 220, "end_pos": 222 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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"glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ECM2", "url": "https://www.uniprot.org/uniprotkb/F1MG02", "locus": { "chromosome": "8", "start_pos": 84108463, "end_pos": 84148223, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024081", "url": "https://www.ensembl.org/id/ENSBTAG00000024081" } ] } } ], "crossref": [ { "id": "F1MG02", "url": "https://alphafold.ebi.ac.uk/entry/F1MG02", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000024081", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024081", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043184", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MG02", "url": "https://www.orthodb.org/?gene=F1MG02", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46544", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46544", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46544:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46544:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00093", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00093", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MG02", "url": "https://www.uniprot.org/uniprotkb/F1MG02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG02-1", "url": "https://www.uniprot.org/uniprotkb/F1MG02-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKFSSLYCFLLLLIFQTDFGQNEETSRRQRRKMYHRRLRKSSLSTHRSVRQPGIQQMKTVTPAAKLPIINLDYSIEENFESFLSVPGVESSYNVLPGKKGHCLANGMIMYNKAVWSPEPCTTCLCLNGKVLCDETKCHPQMCPQTIIPEGECCPVCSDTVASYLLLSGTALNDRTEFSGDSSEQREPTNLPHKQQSPPWEEMNRALRKEELQLEEDEEEVKQDENREQKKKTFRPGDWGRPINEGQSREGKAQRPEEEGRQAHQHRNPARENEEDDDEEEEDDDDEEEDDDDEDETIRGDTFRMPPRLPIPATPRGIPSLPSMCSLSYKTISCISADLTQIPPLTAPEITSLELIDNSITSIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKFLKNLMRLNMDGNNLVTIPSELPSTLEELKINENKLQVIDEESLSDLNQLVTLELEGNNLSETNVNSLAFKPLKSLSYLRLGRNKFRIIPQGLPASIEELYLENNQIEEITEISFNHTRKINVIGLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLVHLVLIGNQIERIPGYVFGHMEPGLEYLYLSFNKLVDDGIDRVSFYGAYHSLRELFLDHNELKSIPPGVQEMKALHFLRLNNNKIRNILPEQICNAEEDDDSNLQHLHLGNNYIKTREIPSYAFSCIRSYSSIVLKPQNIK", "length": 703, "header": "tr|F1MG02-1|F1MG02_BOVIN Isoform 1 of Extracellular matrix protein 2 OS=Bos taurus OX=9913 GN=ECM2 PE=3 SV=4 CANONICAL=F1MG02-1" }, "isoforms": [ { "isoform_ac": "F1MG02-1", "url": "https://www.uniprot.org/uniprotkb/F1MG02/entry", "sequence": { "sequence": "MKFSSLYCFLLLLIFQTDFGQNEETSRRQRRKMYHRRLRKSSLSTHRSVRQPGIQQMKTVTPAAKLPIINLDYSIEENFESFLSVPGVESSYNVLPGKKGHCLANGMIMYNKAVWSPEPCTTCLCLNGKVLCDETKCHPQMCPQTIIPEGECCPVCSDTVASYLLLSGTALNDRTEFSGDSSEQREPTNLPHKQQSPPWEEMNRALRKEELQLEEDEEEVKQDENREQKKKTFRPGDWGRPINEGQSREGKAQRPEEEGRQAHQHRNPARENEEDDDEEEEDDDDEEEDDDDEDETIRGDTFRMPPRLPIPATPRGIPSLPSMCSLSYKTISCISADLTQIPPLTAPEITSLELIDNSITSIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKFLKNLMRLNMDGNNLVTIPSELPSTLEELKINENKLQVIDEESLSDLNQLVTLELEGNNLSETNVNSLAFKPLKSLSYLRLGRNKFRIIPQGLPASIEELYLENNQIEEITEISFNHTRKINVIGLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLVHLVLIGNQIERIPGYVFGHMEPGLEYLYLSFNKLVDDGIDRVSFYGAYHSLRELFLDHNELKSIPPGVQEMKALHFLRLNNNKIRNILPEQICNAEEDDDSNLQHLHLGNNYIKTREIPSYAFSCIRSYSSIVLKPQNIK", "length": 703, "header": "tr|F1MG02-1|F1MG02_BOVIN Isoform 1 of Extracellular matrix protein 2 OS=Bos taurus OX=9913 GN=ECM2 PE=3 SV=4 CANONICAL=F1MG02-1" }, "locus": { "chromosome": "8", "start_pos": 84137228, "end_pos": 84108485, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015726.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015726.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015726.7", "url": "https://www.ensembl.org/id/ENSBTAP00000015726.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "F1MG02", "url": "https://www.uniprot.org/uniprotkb/F1MG02" } ], "pmid": "" }, { "name": "collagen V binding", "id": "GO:0070052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070052", "evidence": [ { "database": "UniProtKB", "id": "F1MG02", "url": "https://www.uniprot.org/uniprotkb/F1MG02" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "F1MG02", "url": "https://www.uniprot.org/uniprotkb/F1MG02" } ], "pmid": "" }, { "name": "positive regulation of cell-substrate adhesion", "id": "GO:0010811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010811", "evidence": [ { "database": "UniProtKB", "id": "F1MG02", "url": "https://www.uniprot.org/uniprotkb/F1MG02" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "F1MG02", "url": "https://www.uniprot.org/uniprotkb/F1MG02" } ], "pmid": "" }, { "name": "interstitial matrix", "id": "GO:0005614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005614", "evidence": [ { "database": "UniProtKB", "id": "F1MG02", "url": "https://www.uniprot.org/uniprotkb/F1MG02" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" }, { "start_pos": 453, "end_pos": 455, "annotation": "n_glycosylation_sequon" }, { "start_pos": 510, "end_pos": 512, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MG02-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 703, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MG02-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MG02" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MG02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG02" }, { "id": "PS50184", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50184" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFC", "eco_id": "ECO_0000259", "start_pos": 100, "end_pos": 157, "start_aa": "Gly", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 382, "end_pos": 384 }, { "start_pos": 453, "end_pos": 455 }, { "start_pos": 510, "end_pos": 512 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MG20-1", "uniprot_ac": "F1MG20", "uniprot_id": "F1MG20_BOVIN", "mass": { "chemical_mass": 36186.0, "monoisotopic_mass": 36186.0 }, "refseq": {}, "gene_names": [ { "name": "HSD17B6", "type": "recommended", "evidence": [ { "id": "F1MG20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG20" } ] } ], "protein_names": [ { "name": "Hydroxysteroid (17-beta) dehydrogenase 6", "type": "synonym", "evidence": [ { "id": "F1MG20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG20/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MG20", "url": "https://www.uniprot.org/uniprotkb/F1MG20" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HSD17B6", "url": "https://www.uniprot.org/uniprotkb/F1MG20", "locus": { "chromosome": "5", "start_pos": 56673709, "end_pos": 56696413, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011720", "url": "https://www.ensembl.org/id/ENSBTAG00000011720" } ] } } ], "crossref": [ { "id": "F1MG20", "url": "https://alphafold.ebi.ac.uk/entry/F1MG20", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011720", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011720", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09805", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09805", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002347", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002347", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036291", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036291", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FFDAYHD", "url": "https://omabrowser.org/oma/group/FFDAYHD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MG20", "url": "https://www.orthodb.org/?gene=F1MG20", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43313", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43313", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43313:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43313:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00106", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00106", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2453902", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2453902", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MG20", "url": "https://www.uniprot.org/uniprotkb/F1MG20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG20-1", "url": "https://www.uniprot.org/uniprotkb/F1MG20-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWLYLAVLLGLYYLLRWYQERQVVSHLQDKFVFITGCDSGFGNQLARQLDLRGLRVLAGCLTEQGAEQLRNQTSDRLQTVILDVTKTESIAAATEWVKECVGDRGLWGLVNNAGIFHSHGYAEWIKIETYRDTLRVNLIGVIEVTLSMLPLVRKAQGRIVNVSSILGRIAFFGAVYSCSKYGVEAFSDILRRELQHFGVKVSMVEPGYFRTAMTDWQKFSEIMKQIWKETPAHIKETYGQKFFDAYHDLMKQGLLSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFVPLSYLPTSLADYILTRSWPKPAQAV", "length": 317, "header": "tr|F1MG20-1|F1MG20_BOVIN Isoform 1 of Hydroxysteroid (17-beta) dehydrogenase 6 OS=Bos taurus OX=9913 GN=HSD17B6 PE=3 SV=2 CANONICAL=F1MG20-1" }, "isoforms": [ { "isoform_ac": "F1MG20-1", "url": "https://www.uniprot.org/uniprotkb/F1MG20/entry", "sequence": { "sequence": "MWLYLAVLLGLYYLLRWYQERQVVSHLQDKFVFITGCDSGFGNQLARQLDLRGLRVLAGCLTEQGAEQLRNQTSDRLQTVILDVTKTESIAAATEWVKECVGDRGLWGLVNNAGIFHSHGYAEWIKIETYRDTLRVNLIGVIEVTLSMLPLVRKAQGRIVNVSSILGRIAFFGAVYSCSKYGVEAFSDILRRELQHFGVKVSMVEPGYFRTAMTDWQKFSEIMKQIWKETPAHIKETYGQKFFDAYHDLMKQGLLSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFVPLSYLPTSLADYILTRSWPKPAQAV", "length": 317, "header": "tr|F1MG20-1|F1MG20_BOVIN Isoform 1 of Hydroxysteroid (17-beta) dehydrogenase 6 OS=Bos taurus OX=9913 GN=HSD17B6 PE=3 SV=2 CANONICAL=F1MG20-1" }, "locus": { "chromosome": "5", "start_pos": 56685859, "end_pos": 56674713, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015564.4", "url": "https://www.ensembl.org/id/ENSBTAT00000015564.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015564.3", "url": "https://www.ensembl.org/id/ENSBTAP00000015564.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2453902", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2453902", "resource": "Reactome", "description": "The canonical retinoid cycle in rods (twilight vision)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1W6H0-1", "protein_name": "Hydroxysteroid 17-beta dehydrogenase 6", "gene_name": "HSD17B6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWLYLAVLVGLYYLLRWYRERQMVSHLGDKYVFITGCDSGFGNLLARQLDVRGLRVLAACLTEQGAQQLRKQTSDRLETVLLDVTKTESIAAATQWVKERVGDRGLWGLVNNAGTFHPLCITEWLKTETWIHTLKVNLIGVTEVTLSMLPLVKKAQGRIVNVSSILGRVAFFGAVYSSSKHGVEAFSDVLRCELQHFGVKVSIVEPGYFRTGMTDVQKSSEAMKQVWKEVPAHIKDTYGQKFFDAYHDVMKQGLSSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFIPLSYLPTSLADYILTRSWPKPVQAV", "length": 317 }, "evidence": [ { "id": "F1MG20", "url": "https://omabrowser.org/oma/group/F1MG20/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O14756-1", "protein_name": "17-beta-hydroxysteroid dehydrogenase type 6", "gene_name": "HSD17B6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYILTRSWPKPAQAV", "length": 317 }, "evidence": [ { "id": "F1MG20", "url": "https://omabrowser.org/oma/group/F1MG20/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O54753-1", "protein_name": "17-beta-hydroxysteroid dehydrogenase type 6", "gene_name": "Hsd17b6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWFYLVTLVGLYYLLRWYRERQVVSHLHDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLTEKGAEELKSKTSDRLETVILDVTNTDSISAATQWVKEHVGDKGLWGLVNNAGVFQAFAYIEWCRPEDCMSIFQVNLIGLAQVTLSMLFLVKKARGRIVNVSSVLGRVALFGGFYSCSKYGVEAFSDVLRREIRDFGVKVSIIEPGSFKTRMTDAELIIEKTKKTWEATPEHIRESYGQQFFDDFCNTTRRELKKCSTNLSLVTDCMEHALTSKYPRTRYSAGWDARLFFIPLSYLPTSLVDCLLAISRRKPAQAV", "length": 317 }, "evidence": [ { "id": "F1MG20", "url": "https://omabrowser.org/oma/group/F1MG20/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9R092-1", "protein_name": "17-beta-hydroxysteroid dehydrogenase type 6", "gene_name": "Hsd17b6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"MERLTPRGPPGHPHQREASTCWRLTVKVLEARGLGWADLLSKADPYVVLQMPTAPGTKFKTKTVTNSSHPVWNETFTFLIQGQVKNVLELTLYDEDTVTQDDAWFKVLYDVSEVLPGRLLRKTFSLRTQGPEELDVEFLIEKMSDRPENLITNNVLVARELSRLDVHVVSMAVAADQDELELVLKGSYEDTQTSTLGTASAFCFHYMAAQEAELSGCLRSSISSGWNSGHLAGHLTVPLRSLAMEKEVTIDVPATNAPGVKLQLKAESCPEELAVHLGFDLSVEERAFLSRRKQVVAKALKQVLQLDGDLQEDEVPVIGIMATGGGARAMTSLYGQLLALQKLGLLDCVTYFSGISGSTWTMAHLYGDPEWSQKDLKGPISHVREHLAKSKLEVFSPKCLASYHRELQQRAEQGRTTTFVDLWGLVLELMLHGQVVDQKLSGQRAALERGQNPLPLYLSLSVKENSLQTLDFKEWVEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMKRLPESRICFLEGIWSNIFSLNLLDAWYDLTSSDDTWKQHIRDKIRDLGKEPGVSPASSGTSSWPETLWMQPGTALAQMFKGLLTSRPLYQHSSNFLQGLQMHKDYCAQKDFTTWADCRPDSSPNQLTPQEPQLCLVDAGYFINTSCPVMFRPGRRLDLIISFDYSLSSPFEVLQQTELDFRARGLPFPRVEPSPKDRRQPQECHLFSDPACPDAPVVLHFPLVNASFKDHSAPGVQRGPAELSAGQIDLTGVTSPYSTFNMTYKEEDFDRLVQLSDYNVRSSQDTILQALRTVLKHRAPEARPPRVQT", "length": 816, "header": "tr|F1MG30-1|F1MG30_BOVIN Isoform 1 of Phospholipase A2 OS=Bos taurus OX=9913 GN=PLA2G4D PE=4 SV=2 CANONICAL=F1MG30-1" }, "isoforms": [ { "isoform_ac": "F1MG30-1", "url": "https://www.uniprot.org/uniprotkb/F1MG30/entry", "sequence": { "sequence": "MERLTPRGPPGHPHQREASTCWRLTVKVLEARGLGWADLLSKADPYVVLQMPTAPGTKFKTKTVTNSSHPVWNETFTFLIQGQVKNVLELTLYDEDTVTQDDAWFKVLYDVSEVLPGRLLRKTFSLRTQGPEELDVEFLIEKMSDRPENLITNNVLVARELSRLDVHVVSMAVAADQDELELVLKGSYEDTQTSTLGTASAFCFHYMAAQEAELSGCLRSSISSGWNSGHLAGHLTVPLRSLAMEKEVTIDVPATNAPGVKLQLKAESCPEELAVHLGFDLSVEERAFLSRRKQVVAKALKQVLQLDGDLQEDEVPVIGIMATGGGARAMTSLYGQLLALQKLGLLDCVTYFSGISGSTWTMAHLYGDPEWSQKDLKGPISHVREHLAKSKLEVFSPKCLASYHRELQQRAEQGRTTTFVDLWGLVLELMLHGQVVDQKLSGQRAALERGQNPLPLYLSLSVKENSLQTLDFKEWVEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMKRLPESRICFLEGIWSNIFSLNLLDAWYDLTSSDDTWKQHIRDKIRDLGKEPGVSPASSGTSSWPETLWMQPGTALAQMFKGLLTSRPLYQHSSNFLQGLQMHKDYCAQKDFTTWADCRPDSSPNQLTPQEPQLCLVDAGYFINTSCPVMFRPGRRLDLIISFDYSLSSPFEVLQQTELDFRARGLPFPRVEPSPKDRRQPQECHLFSDPACPDAPVVLHFPLVNASFKDHSAPGVQRGPAELSAGQIDLTGVTSPYSTFNMTYKEEDFDRLVQLSDYNVRSSQDTILQALRTVLKHRAPEARPPRVQT", "length": 816, "header": "tr|F1MG30-1|F1MG30_BOVIN Isoform 1 of Phospholipase A2 OS=Bos taurus OX=9913 GN=PLA2G4D PE=4 SV=2 CANONICAL=F1MG30-1" }, "locus": { "chromosome": "10", "start_pos": 37507804, "end_pos": 37485786, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003576.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003576.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003576.4", "url": "https://www.ensembl.org/id/ENSBTAP00000003576.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:531209", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531209", "resource": "KEGG Pathway" }, { "id": "R-BTA-1482788", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482788", "resource": "Reactome", "description": "Acyl chain remodelling of PC" }, { "id": "R-BTA-1482801", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482801", "resource": "Reactome", "description": "Acyl chain remodelling of PS" }, { "id": "R-BTA-1482839", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482839", "resource": "Reactome", "description": "Acyl chain remodelling of PE" }, { "id": "R-BTA-1482922", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482922", "resource": "Reactome", "description": "Acyl chain remodelling of PI" }, { "id": "R-BTA-1482925", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482925", "resource": "Reactome", "description": "Acyl chain remodelling of PG" }, { "id": "R-BTA-1483115", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483115", "resource": "Reactome", "description": "Hydrolysis of LPC" }, { "id": "R-BTA-1483166", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483166", "resource": "Reactome", "description": "Synthesis of PA" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZQH6-1", "protein_name": "Phospholipase A2", "gene_name": "Pla2g4d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWSGDRRVVMESLSPERLPVYPRQEEASVFCQLTVKILEARSLPRADLLSKADPYVTLRLPTASGRKFKTQTVTNSSNPVWNETFSFLIQSQVKNILELTVYDEDLITKDDICFKISYDISEILPGQLVQKTFSLNPQGPEELDVEFLVERTCDPPENLITNNVLVARELSHLDVSLDRAGSTTMAAGQDKLELELMLKGSYEDTQTFLPDTAFTLSFHYMRSQDTELNGYLRSSRNSDWNSDTSATPFNVPLTLLAAGKEVTVDIPATKDPERKLQLKTDSCPKELSVRLSYGLCPEEQAFLGRRKKLVAAALKQALQLDEDLKEDEVPVVGINAEGGGMRAMISLYGHLLALQKLGLLDCVTYFSGISGATWTMAHLYRDPEWSQKDLEGPISHAREHVAKSLLKEFLPEHLASYRQTLKLREEQGYTVTIADLWGLVLESKLHGQVTDQKLSEQRAALERGQNPLPLYLSLNVKENHLETLHFKEWVEFSPYEVGFLKYGGFVPSELFGSEFFMGRLMKRLPESQICFLEGIWSNLFSVNLMDIWYDITSGRDSNDFPVDVQNSEKEPSSSAGVSSGVEAPWLQPGTALAQAFKGFLTGRPFNQRSANFLHGLQLHRDYCNQRDFSTWADCNLDDTPNQLTPQDPQLCLIDAGCFMNSSCPSLFRSGRQVDLILSFNYNQSFPFKGLQQSGKYCSAQGLPFPRVEPSPEDHLQPQECYLFSDPTCPEAPAVLHFPLVNDSFQDHSAPGVRRSPDELKAGQVDLTGVASPYFLYNMTYKNEDFDRLLRLSEYNIQNNQGTILQALKTVLKRRASETRPLGVKT", "length": 825 }, "evidence": [ { "id": "F1MG30", "url": "https://omabrowser.org/oma/group/F1MG30/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q50L43-1", "protein_name": "Cytosolic phospholipase A2 delta", "gene_name": "Pla2g4d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWSGDRRVGMESLSPERLHGHPYQEEASVFCRLTVKILEARSLPRADLLSQADPYVTVQLPTASGMKFKTQTVTNSSHPVWNETFSFLIQSQVKNILELTIYDEDVITKDDICFKVSYDVSEILPGQLLQKTFSLNPQGPEELDVELLMERTWDPPENLITNNVLVARELSHLDVSLDRAGNTAMAAGQDKLELELMLKGSYEDTQTFFPDTAFTFSFHYMRGQDTELNGYLRGPRNSGWNSDTSVTPFNVPLMSLAAGKEMTIDIPAMKAPEGKLQLKTDCCPKELSVRLSYGLCPEEQAFLSRRKKVVAAALKQALQLDEDLNEDEVPVVGINAEGGGMRAMISLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYRDPEWSQRDLEGPISHAREHVAKTLLKEFLPEHLASYRQTLKLREEQGYTVTVADLWGLVLESKLHGQVTDQKLSGQRAALERGQNPLPLYLSLNVKENHLETLHFKEWVEFSPYEVGFLKYGGFVPSELFGSEFFMGRLMKRLPESQICFLEGIWSNLFSVNLMDIWYDITYGKDSNNFPVDVRNSEKEFSGSAGTSSGVEAPWLESGTALAQALKGFLTGRPFHQRSANFLHGLQLHRDYCNQRHFSTWADCNLDDTPNQLTPQDPQLCLIDAGCFMNSSCPSLFRPGRQVDLIISFNYNQSLPFKGLQQSEKYSRARGLPFPRVEPSPEDHSQPQECYLFSDPTCPEAPVVLHFPLVNDSFRDHSAPGVRRSPDELKAGQVNLTGAASPYFMYNMTYKNEDFDRLLQLSDYNVQNNQGTILQALRTVLKRRASETRPLGVKT", "length": 825 }, "evidence": [ { "id": "F1MG30", "url": "https://omabrowser.org/oma/group/F1MG30/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86XP0-1", "protein_name": "Cytosolic phospholipase A2 delta", "gene_name": "PLA2G4D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESLSPGGPPGHPYQGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFSQSPQGEEELDVEFLMEETSDRPENLITNKVIVARELSCLDVHLDSTGSTAVVADQDKLELELVLKGSYEDTQTSFLGTASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYLTVPLRPLTIGKEVTMDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQVVAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQGHPTTFVDLWALVLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEWVEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWYDLTSSGESWKQHIKDKTRSLEKEPLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQRSPNFLQGLQLHQDYCSHKDFSTWADYQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMFRPGRRLDLILSFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPACPEAPILLHFPLVNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFERLLRLSDYNVQTSQGAILQALRTALKHRTLEARPPRAQT", "length": 818 }, "evidence": [ { "id": "F1MG30", "url": "https://omabrowser.org/oma/group/F1MG30/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MG30", "url": "https://www.uniprot.org/uniprotkb/F1MG30" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MG30", "url": "https://www.uniprot.org/uniprotkb/F1MG30" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MG30", "url": "https://www.uniprot.org/uniprotkb/F1MG30" } ], "pmid": "" }, { "name": "phosphatidylcholine lysophospholipase activity", "id": "GO:0004622", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004622", "evidence": [ { "database": "UniProtKB", "id": "F1MG30", "url": "https://www.uniprot.org/uniprotkb/F1MG30" } ], "pmid": "" }, { "name": "phospholipase A2 activity", "id": "GO:0004623", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004623", "evidence": [ { "database": "UniProtKB", "id": "F1MG30", "url": "https://www.uniprot.org/uniprotkb/F1MG30" } ], "pmid": "" }, { "name": "calcium-dependent phospholipid binding", "id": "GO:0005544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005544", "evidence": [ { "database": "UniProtKB", "id": "F1MG30", "url": "https://www.uniprot.org/uniprotkb/F1MG30" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "glycerophospholipid catabolic process", "id": "GO:0046475", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046475", "evidence": [ { "database": "UniProtKB", "id": "F1MG30", "url": "https://www.uniprot.org/uniprotkb/F1MG30" } ], "pmid": "" }, { "name": "leukotriene biosynthetic process", "id": "GO:0019370", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019370", "evidence": [ { "database": "UniProtKB", "id": "F1MG30", "url": "https://www.uniprot.org/uniprotkb/F1MG30" } ], "pmid": "" }, { "name": "glycerol metabolic process", "id": "GO:0006071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006071", "evidence": [ { "database": "UniProtKB", "id": "F1MG30", "url": "https://www.uniprot.org/uniprotkb/F1MG30" } ], "pmid": "" }, { "name": "prostaglandin biosynthetic process", "id": "GO:0001516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001516", "evidence": [ { "database": "UniProtKB", "id": "F1MG30", "url": "https://www.uniprot.org/uniprotkb/F1MG30" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 651, "end_pos": 653, "annotation": "n_glycosylation_sequon" }, { "start_pos": 66, "end_pos": 68, "annotation": "n_glycosylation_sequon" }, { "start_pos": 732, "end_pos": 734, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" }, { "start_pos": 768, "end_pos": 770, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15177", "name": "", "equation": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9T0P5-1", "Q8WMP9-1", "A4IFJ5-1", "A0A3Q1LV96-1", "Q3SZ79-1", "G3X6Z1-1", "F1MNU5-1", "E1BB89-1", "A0AAA9RYE9-1", "E1BC49-1", "F1MG30-1", "F1MGH2-1", "F1MFC1-1" ], "evidence": [ { "id": "15177", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15177" } ] }, { "id": "15801", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MFC1-1", "F1MG30-1", "E1BB89-1", "E1BC49-1", "Q8WMP9-1", "P00593-1", "A4IFJ5-1", "A0A3Q1LV96-1", "E1BLF3-1", "O77834-1", "E1B9V3-1", "E1BEG8-1", "A0AAA9T9W1-1", "Q56JZ2-1", "G3N3U6-1", "Q0VC00-1", "Q1JPB9-1", "Q2KI18-1", "A0A3Q1LNM7-1", "F1MNU5-1", "F1MSG5-1", "F6RTH3-1", "A0AAA9TQC6-1", "G5E5T0-1", "A0AAA9RYE9-1", "A0ABI0P1I9-1" ], "evidence": [ { "id": "15801", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15801" } ] }, { "id": "36231", "name": "", "equation": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "P79106-1", "A0A3Q1LV96-1", "F1MNU5-1", "E1BB89-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "36231", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36231" } ] }, { "id": "40427", "name": "", "equation": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BC49-1", "F1MFC1-1", "F1MG30-1", "A4IFJ5-1", "P00593-1", "Q1JPB9-1", "F1MNU5-1", "E1BB89-1", "A0AAA9RYE9-1" ], "evidence": [ { "id": "40427", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40427" } ] }, { "id": "40451", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "40451", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40451" } ] }, { "id": "40519", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BB89-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "40519", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40519" } ] }, { "id": "40811", "name": "", "equation": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "A0A3Q1LV96-1", "E1BLF3-1", "Q56JZ2-1", "Q1JPB9-1", "F1MNU5-1", "E1BB89-1", "A0AAA9RYE9-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "40811", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40811" } ] }, { "id": "41067", "name": "", "equation": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BB89-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41067", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41067" } ] }, { "id": "41071", "name": "", "equation": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41071", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41071" } ] }, { "id": "41075", "name": "", "equation": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41075", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41075" } ] }, { "id": "41087", "name": "", "equation": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41087", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41087" } ] }, { "id": "41099", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41099", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41099" } ] }, { "id": "41123", "name": "", "equation": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41123", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41123" } ] }, { "id": "41271", "name": "", "equation": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 2-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41271", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41271" } ] }, { "id": "41307", "name": "", "equation": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "41307", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41307" } ] }, { "id": "53688", "name": "", "equation": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "53688", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53688" } ] }, { "id": "53692", "name": "", "equation": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O = prostaglandin E2 + sn-glycerol 3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "53692", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53692" } ] }, { "id": "53696", "name": "", "equation": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "53696", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53696" } ] }, { "id": "53700", "name": "", "equation": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "53700", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53700" } ] }, { "id": "53704", "name": "", "equation": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O = sn-glycero-3-phosphoethanolamine + prostaglandin E2 + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A4IFJ5-1", "F1MNU5-1", "E1BC49-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "53704", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53704" } ] }, { "id": "R-BTA-1482604", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial outer membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-1524103" ], "enzyme_list": [ "F1MG30-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482604", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482604" } ] }, { "id": "R-BTA-1482612", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-975614" ], "output_participant_list": [ "R-ALL-1498750" ], "enzyme_list": [ "Q9GL30-1", "F1MNU5-1", "F1MG30-1", "F1MFC1-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482612", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482612" } ] }, { "id": "R-BTA-1482656", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MG30-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482656", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482656" } ] }, { "id": "R-BTA-1482685", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-1524028" ], "output_participant_list": [], "enzyme_list": [ "Q9GL30-1", "F1MNU5-1", "F1MG30-1", "F1MFC1-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482685", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482685" } ] }, { "id": "R-BTA-1482745", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [ "R-ALL-1524042" ], "output_participant_list": [ "R-ALL-1524027", "R-ALL-1524085" ], "enzyme_list": [ "F1MNU5-1", "F1MG30-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482745", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482745" } ] }, { "id": "R-BTA-1482771", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[9]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MNU5-1", "F1MG30-1", "F1MFC1-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482771", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482771" } ] }, { "id": "R-BTA-1482825", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[11]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9GL30-1", "F1MNU5-1", "F1MG30-1" ], "evidence": [ { "id": "R-BTA-1482825", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482825" } ] }, { "id": "R-BTA-1482828", "name": "PE is hydrolyzed to 2-acyl LPE by PLA2[4]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MNU5-1", "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "R-BTA-1482828", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482828" } ] }, { "id": "R-BTA-1482847", "name": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [], "output_participant_list": [ "R-ALL-1524047" ], "enzyme_list": [ "F1MNU5-1", "F1MG30-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482847", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482847" } ] }, { "id": "R-BTA-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9GL30-1", "F1MNU5-1", "F1MG30-1", "E1BB89-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482856", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482856" } ] }, { "id": "R-BTA-1482862", "name": "PC is hydrolysed to 2-acyl LPC by PLA2[7]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MNU5-1", "F1MG30-1", "F1MFC1-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482862", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482862" } ] }, { "id": "R-BTA-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9GL30-1", "F1MNU5-1", "F1MG30-1", "F1MFC1-1", "E1BB89-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482884", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482884" } ] }, { "id": "R-BTA-1482897", "name": "PS is hydrolyzed to 2-acyl LPS by PLA2[10]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MNU5-1", "F1MG30-1" ], "evidence": [ { "id": "R-BTA-1482897", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482897" } ] }, { "id": "R-BTA-1482900", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MG30-1", "E1BC49-1" ], "evidence": [ { "id": "R-BTA-1482900", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482900" } ] }, { "id": "R-BTA-1482920", "name": "PG is hydrolyzed to 2-acyl LPG by PLA2[14]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-1483256" ], "output_participant_list": [ "R-ALL-1498730" ], "enzyme_list": [ "F1MNU5-1", "F1MG30-1" ], "evidence": [ { "id": "R-BTA-1482920", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482920" } ] }, { "id": "R-BTA-1482932", "name": "PI is hydrolyzed to 2-acyl LPI by PLA2[13]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-1498737" ], "enzyme_list": [ "F1MG30-1", "F1MFC1-1" ], "evidence": [ { "id": "R-BTA-1482932", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1482932" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1483256", "participant_name": "PG [endoplasmic reticulum membrane]", "crossref": [ { "id": "64716", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1498730", "participant_name": "2-acyl LPG [endoplasmic reticulum membrane]", "crossref": [ { "id": "27923", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1498737", "participant_name": "2-acyl LPI [endoplasmic reticulum membrane]", "crossref": [ { "id": "62746", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1498750", "participant_name": "GPCho [cytosol]", "crossref": [ { "id": "ZINC000001532714", "database": "ZINC", "url": "" }, { "id": "16870", "database": "ChEBI", "url": "" }, { "id": "HMDB0000086", "database": "HMDB Metabolite", "url": "" }, { "id": "C00670", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-1524027", "participant_name": "1-acyl LPG [mitochondrial inner membrane]", "crossref": [ { "id": "62747", "database": "ChEBI", "url": "" }, { "id": "C18126", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-1524028", "participant_name": "1-acyl LPC [endoplasmic reticulum membrane]", "crossref": [ { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-1524042", "participant_name": "PG [mitochondrial inner membrane]", "crossref": [ { "id": "64716", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1524047", "participant_name": "2-acyl LPG [mitochondrial inner membrane]", "crossref": [ { 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1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "G5E5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5T0" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "G5E5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5T0" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "G5E5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5T0" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "G5E5T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5T0" } ] } ] }, { "uniprot_ac": "O77834", "gene_name": "PRDX6", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "O77834", "database": 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"id": "P00593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00593" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P00593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00593" } ] } ] }, { "uniprot_ac": "P79106", "gene_name": "PAFAH2", "activity": [ { "ec_number": "2.3.1.149", "activity": "a 1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = a 1-organyl-2-acetyl-sn-glycero-3-phospholipid + a 1-O-alkyl-sn-glycero-3-phosphocholine.", "evidence": [ { "id": "P79106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79106" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P79106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79106" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P79106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P79106" } ] } ] }, { "uniprot_ac": "Q0VC00", "gene_name": "ABHD3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] }, { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q0VC00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VC00" } ] } ] }, { "uniprot_ac": "Q1JPB9", "gene_name": "PLA2G3", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q1JPB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPB9" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q1JPB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPB9" } ] } ] }, { "uniprot_ac": "Q2KI18", "gene_name": "PNPLA2", "activity": [ { "ec_number": "3.1.1.4", "activity": "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q2KI18", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KI18" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", 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"uniprot_canonical_ac": "F1MG31-1", "uniprot_ac": "F1MG31", "uniprot_id": "F1MG31_BOVIN", "mass": { "chemical_mass": 111028.0, "monoisotopic_mass": 111028.0 }, "refseq": {}, "gene_names": [ { "name": "CDCA2", "type": "recommended", "evidence": [ { "id": "F1MG31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG31" } ] } ], "protein_names": [ { "name": "Cell division cycle associated 2", "type": "synonym", "evidence": [ { "id": "F1MG31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG31/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MG31", "url": "https://www.uniprot.org/uniprotkb/F1MG31" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CDCA2", "url": "https://www.uniprot.org/uniprotkb/F1MG31", "locus": { "chromosome": "8", "start_pos": 72865583, "end_pos": 72823419, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002756", "url": "https://www.ensembl.org/id/ENSBTAG00000002756" } ] } } ], "crossref": [ { "id": "F1MG31", "url": "https://alphafold.ebi.ac.uk/entry/F1MG31", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002756", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002756", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR029334", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029334", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QKECDCS", "url": "https://omabrowser.org/oma/group/QKECDCS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MG31", "url": "https://www.orthodb.org/?gene=F1MG31", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21603", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21603", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21603:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21603:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15276", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15276", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MG31", "url": "https://www.uniprot.org/uniprotkb/F1MG31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG31-1", "url": "https://www.uniprot.org/uniprotkb/F1MG31-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDTCSQESEPLQTKESPINNAGKTPLVLGNGKLVTPHKQAAEMTPNCYTSETFKSPLNFSTVTVEQLGISPESFVNNSSGKSSPYLKKSRRRSTVGLRGLPETNHLIRFVAEQRSLKNASLTQTSPFQGSPALYRNVYSLREQMSAFHLAFNSIKENEKMTDCPEFSEAEGVFKTRGSTKKESLGECQLSEFSAQSSSKRRRLSSPSSSDVNLTDAVDLQACGVNMAACPSTDMKCAVETCAGLSQKSSASGLNLQCGCLMNESPLLSELTEASSGIQDAASVEERGSNDAVSVDKCTEVSTDTAPEVRSLVTPLCQKDLPSSKTFVLRSVLKKPAVKLCVESLQEHLDNLYNDETCPSLTSSLANSCKEQTAALPNTKKRKRVTFGEDLSPEVFDESLPANTPLRKGQTPVRKKDLSSLSPPLLEQSPVPEWLPQPNFDDKEENLENIEPLQVSFAVLSSLNMSSIAETLSGTDTSASSSNHENIAPFRVGRATRTSDRRSKLISFSQESVCNLLNAEAQPCKEKKTNRRKSQESKHADKVLPRKNRVLKGCKKKKGKGKRKGVQKSLYGERDLASKKPLLSPIPELPEVSETPLVGSLVRRTYPDDFNSNGKFEEMMLPKRENLLSQDPEDWQVIQGFNKDNASESCSSDMKSSSSFSNATFEQDANINSIEMDENENIPKAITLESENERKTGTECENSHISCTLVTVTPVVSDNPKPDFPLQSQELSAAGQNVENLFQIVKISEDMNIKCEKQSGFSVIPEDKLQTEHLIPDSQKECDCSEDVLTDQRKVSKSQGEDLGRNSAASCSGVSDRERKYRGHSVGGSDGPGLHLERTNNLQPSYSMSSLVEISLENSELCKDLSDSIEQSLQRTKSETKVRRSLRLQKSLEREGGLVWVSPPPPPASCTSQRTKRRTVGTLDSRGFEPVSSRQDPCTLPSTSSEENGEGFTAAPDASLPGKRRRRSFCTSTLANPKSTTQSRGCKRRSFLGQKRENTLQETSRESDLSEN", "length": 1011, "header": "tr|F1MG31-1|F1MG31_BOVIN Isoform 1 of Cell division cycle associated 2 OS=Bos taurus OX=9913 GN=CDCA2 PE=4 SV=3 CANONICAL=F1MG31-1" }, "isoforms": [ { "isoform_ac": "F1MG31-1", "url": "https://www.uniprot.org/uniprotkb/F1MG31/entry", "sequence": { "sequence": "MDTCSQESEPLQTKESPINNAGKTPLVLGNGKLVTPHKQAAEMTPNCYTSETFKSPLNFSTVTVEQLGISPESFVNNSSGKSSPYLKKSRRRSTVGLRGLPETNHLIRFVAEQRSLKNASLTQTSPFQGSPALYRNVYSLREQMSAFHLAFNSIKENEKMTDCPEFSEAEGVFKTRGSTKKESLGECQLSEFSAQSSSKRRRLSSPSSSDVNLTDAVDLQACGVNMAACPSTDMKCAVETCAGLSQKSSASGLNLQCGCLMNESPLLSELTEASSGIQDAASVEERGSNDAVSVDKCTEVSTDTAPEVRSLVTPLCQKDLPSSKTFVLRSVLKKPAVKLCVESLQEHLDNLYNDETCPSLTSSLANSCKEQTAALPNTKKRKRVTFGEDLSPEVFDESLPANTPLRKGQTPVRKKDLSSLSPPLLEQSPVPEWLPQPNFDDKEENLENIEPLQVSFAVLSSLNMSSIAETLSGTDTSASSSNHENIAPFRVGRATRTSDRRSKLISFSQESVCNLLNAEAQPCKEKKTNRRKSQESKHADKVLPRKNRVLKGCKKKKGKGKRKGVQKSLYGERDLASKKPLLSPIPELPEVSETPLVGSLVRRTYPDDFNSNGKFEEMMLPKRENLLSQDPEDWQVIQGFNKDNASESCSSDMKSSSSFSNATFEQDANINSIEMDENENIPKAITLESENERKTGTECENSHISCTLVTVTPVVSDNPKPDFPLQSQELSAAGQNVENLFQIVKISEDMNIKCEKQSGFSVIPEDKLQTEHLIPDSQKECDCSEDVLTDQRKVSKSQGEDLGRNSAASCSGVSDRERKYRGHSVGGSDGPGLHLERTNNLQPSYSMSSLVEISLENSELCKDLSDSIEQSLQRTKSETKVRRSLRLQKSLEREGGLVWVSPPPPPASCTSQRTKRRTVGTLDSRGFEPVSSRQDPCTLPSTSSEENGEGFTAAPDASLPGKRRRRSFCTSTLANPKSTTQSRGCKRRSFLGQKRENTLQETSRESDLSEN", "length": 1011, "header": "tr|F1MG31-1|F1MG31_BOVIN Isoform 1 of Cell division cycle associated 2 OS=Bos taurus OX=9913 GN=CDCA2 PE=4 SV=3 CANONICAL=F1MG31-1" }, "locus": { "chromosome": "8", "start_pos": 72865433, "end_pos": 72823419, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003573.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003573.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003573.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003573.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D4ADI8-1", "protein_name": "Cell division cycle associated 2", "gene_name": "Cdca2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDTSSHNKPLSESKECVRHNSENDFFILGTGPLVTPQKHAADMTPNLCTPDTFKSPLDFSTVTVEQLGITPESFVKTPSGKSSSSLQKNRRRSTVGVRGSPETNCLIRFIAQQRSLKKAVRSPMARDPYLEGSPRLYRNASVLRERMSAFRSAFHSIQETEKMAGGPSASEADGESKITDLTKKEGLVEYQQSGFPINCSSKRRRLSSKDILDDYLSGTKMFADGACAGATSTDLAEKSSDISSAQSGYMATPLPDLRQASRGLAVTDCVEGTRSVDAVPLDTPATPLSSGTATTTRTPLIPVCGSSNPSTKTFVLRSVLKKPCQSFSENGKGYNPCDDQAHLITCPSNCCKGGAGRENCKTPGCLNLRKRKRVTFGEDLSPEVFDESLPANTPLCKGGTPVHPRNVSITTSPLQSPVHEQFLQPNFDDKEENLENIAPPQGSFAILSPTKSSFSEIPPGTNTCSPLNKDEEIVYSVGRSTRTSHRRKLLSSAGTGVCNSYTTQAEPCKEKINRRKSQEKKHTSKTLPKKKQARIYRKKKRKGKKGVEKCLYGQRDIASKKPLLSPIPELPEVSEATPLADCTQRTCSDDFNIRGELEEGTSFEIPTKRKRCLPQKEDPPELDPAPDQSVVSDLCCYLLPLPAASEGGPNAGTRDTGSEGNTRADRAESKRQSAKEPKTGTKTESSLAPCASVTHHGHIVSNNPKPLGSLQSQDFLKAGQSLENPCEILTISESMNIKCEKESECLAPQGNLQGSPFSTDSKREHNCSEDVLIENTKESTSHSENAGRKCAENGSTASGRERKWRRHTMYCEGQSSYLDQNRNPASSCSGENSVGIGLGNSQLIEELSNTIEQSFQRPRGKSKVRRSTRLQKDLENTGLVWLSPSPSTFRKTKRRMTICTLDSRGFESTSSKEETLSSGQNPGPLPSISGSESQGVGSSELPRKRRKSFCLSALSDGNSMTQLPHFKRKPSLKKGEGTQLP", "length": 981 }, "evidence": [ { "id": "F1MG31", "url": "https://omabrowser.org/oma/group/F1MG31/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14B71-1", "protein_name": "Cell division cycle-associated protein 2", "gene_name": "Cdca2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDASSHDKPLSESKECVLNNSENDVFRLGTEPFVTPQKHVADATPNLCTPDTFKSPLDFTTVTVEQLGITPESFVKTSSGKSTSSLQKARRRSTVGVRGSPETNCLIRFIAQQRNLKKAVLSPLAREPHFEGSPRLYRNASVLRERMSAFRSAFHSIQETKMASSPSAAEADGESRISDLTRKEDLLEYQQSGFPVNSSSKRRRISSQDSPDNYLSGTKALADEACAGGASTDLAEKSPDIGSAQPGCMAAPLPELRETSQGLAVTDCVEGPVTPLSSGTATATRSPETPMCGSSSPSAKTTATRSPATPVCGSSTPSAKTFVLRSVLKKPGKLFSENGKESNLCDDGAHLISYPSNSCKEGRAGRENCKTPGCLNPRKRKRVTFGEDLSPEVFDESLPANTPLCKGGTPVRPRTVKTTSPLQSPVHEQFLQPNFDDKEENLENIEPPQGSFANLSLSKSSLSETPPGTNTCSSLNKDEEIICSIVRPTRTSQRRKQTLSSTGVCSSYTTQAEPRKEKMSRRKSREKKHTSAALPKKKQVLKSYRKKKKGKKDVEKCFYGPRDIASKKPLLSPIPELPEVSEATPLADCTQGTSSDDFNKCGQLEEVNSFEIPTQRKRRLPQKADSPELDPAHHQSQVSDKCCYLLPLTTASERGPNASTRDTGSEGNTRAESKCQSAKEPKPGTKMESGLVPRASVTQDHIVSKNPKPLGSPQSQDLFKAGQNLENPCEILIVSESMNLKCEKESECLAPQGSLQGSPVSTDSKRDLNCSEDVLIQNIKEPASHSENVGRKCAGNGSPGSGRERKWRRRTVCCGGQSSYLEQNGNPASSCSGENFVEISLESVQLIEELSNTIEQSFQRTSSKTKVRRSTRLQRDLENTGLVWLSPSPSTLQKPRRRMTICTLDSRGFECPSSKEETISSGQNPGPLPAVSGSESQGVGSSALPRKRRSLCGSTLTDANSATQPPDCKRKPSLKGESAQLP", "length": 982 }, "evidence": [ { "id": "F1MG31", "url": "https://omabrowser.org/oma/group/F1MG31/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q69YH5-1", "protein_name": "Cell division cycle-associated protein 2", "gene_name": "CDCA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTVTVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKSPLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLTRKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQIFNIDTDRACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVSSDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSLISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETLSGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGRSLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDLENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGERKQ", "length": 1023 }, "evidence": [ { "id": "F1MG31", "url": "https://omabrowser.org/oma/group/F1MG31/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MG31", "url": "https://www.uniprot.org/uniprotkb/F1MG31" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MG31", "url": "https://www.uniprot.org/uniprotkb/F1MG31" } ], "pmid": "" }, { "name": "condensed chromosome", "id": "GO:0000793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000793", "evidence": [ { "database": "UniProtKB", "id": "F1MG31", "url": "https://www.uniprot.org/uniprotkb/F1MG31" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "F1MG31", "url": "https://www.uniprot.org/uniprotkb/F1MG31" } ], "pmid": "" }, { "name": "regulation of mitotic nuclear division", "id": "GO:0007088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007088", "evidence": [ { "database": "UniProtKB", "id": "F1MG31", "url": "https://www.uniprot.org/uniprotkb/F1MG31" } ], "pmid": "" }, { "name": "meiotic cell cycle", "id": "GO:0051321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321", "evidence": [ { "database": "UniProtKB", "id": "F1MG31", "url": "https://www.uniprot.org/uniprotkb/F1MG31" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein phosphatase regulator activity", "id": "GO:0019888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019888", "evidence": [ { "database": "UniProtKB", "id": "F1MG31", "url": "https://www.uniprot.org/uniprotkb/F1MG31" } ], "pmid": "" }, { "name": "molecular condensate scaffold activity", "id": "GO:0140693", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140693", "evidence": [ { "database": "UniProtKB", "id": "F1MG31", "url": "https://www.uniprot.org/uniprotkb/F1MG31" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" }, { "start_pos": 262, "end_pos": 264, "annotation": "n_glycosylation_sequon" }, { "start_pos": 463, "end_pos": 465, "annotation": "n_glycosylation_sequon" }, { "start_pos": 58, "end_pos": 60, "annotation": "n_glycosylation_sequon" }, { "start_pos": 644, "end_pos": 646, "annotation": "n_glycosylation_sequon" }, { "start_pos": 661, "end_pos": 663, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" }, { "start_pos": 77, "end_pos": 79, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MG31-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1011, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MG31-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MG31" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MG31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG31" }, { "id": "PF15276", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15276" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PP1-binding", "eco_id": "ECO_0000259", "start_pos": 380, "end_pos": 441, "start_aa": "Lys", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 118, "end_pos": 120 }, { "start_pos": 212, "end_pos": 214 }, { "start_pos": 262, "end_pos": 264 }, { "start_pos": 463, "end_pos": 465 }, { "start_pos": 58, "end_pos": 60 }, { "start_pos": 644, "end_pos": 646 }, { "start_pos": 661, "end_pos": 663 }, { "start_pos": 76, "end_pos": 78 }, { "start_pos": 77, "end_pos": 79 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MG37-1", "uniprot_ac": "F1MG37", "uniprot_id": "F1MG37_BOVIN", "mass": { "chemical_mass": 46258.0, "monoisotopic_mass": 46258.0 }, "refseq": { "ac": "XP_002685725", "name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685725" }, "gene_names": [ { "name": "B3GNT7", "type": "recommended", "evidence": [ { "id": "F1MG37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG37" } ] }, { "name": "B3GNT7", "type": "synonym", "evidence": [ { "id": "XP_002685725", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685725" } ] } ], "protein_names": [ { "name": "Hexosyltransferase", "type": "recommended", "evidence": [ { "id": "F1MG37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG37/entry#names_and_taxonomy" } ] }, { "name": "2.4.1.-", "type": "synonym", "evidence": [ { "id": "F1MG37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG37/entry#names_and_taxonomy" } ] }, { "name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7", "type": "synonym", "evidence": [ { "id": "XP_002685725", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685725" } ] } ], "function": [ { "annotation": "N-acetyl glucosamine (GlcNAc) transferase that catalyzes the transfer of GlcNAc via a beta1->3 linkage from UDP-GlcNAc to the non-reducing terminal galactose (Gal) in the linearly growing chain of N-and O-linked keratan sulfate proteoglycans. Cooperates with B4GALT4 galactosyltransferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Involved in biosynthesis of N-linked keratan sulfate proteoglycans in cornea, with an impact on proteoglycan fibril organization and corneal transparency. May play a role in the maintenance of tissue architecture by suppressing cellular motility and invasion.", "evidence": [ { "database": "UniProtKB", "id": "F1MG37", "url": "https://www.uniprot.org/uniprotkb/F1MG37#function" }, { "database": "UniProtKB", "id": "ARBA00058437", "url": "https://www.uniprot.org/uniprotkb/ARBA00058437#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MG37", "url": "https://www.uniprot.org/uniprotkb/F1MG37" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "B3GNT7", "url": "https://www.uniprot.org/uniprotkb/F1MG37", "locus": { "chromosome": "2", "start_pos": 119179815, "end_pos": 119175143, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001359", "url": "https://www.ensembl.org/id/ENSBTAG00000001359" } ] } } ], "crossref": [ { "id": "F1MG37", "url": "https://alphafold.ebi.ac.uk/entry/F1MG37", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001359", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001359", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538799", "url": "https://www.ncbi.nlm.nih.gov/gene/538799", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002659", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002659", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538799", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538799", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MFQWKKT", "url": "https://omabrowser.org/oma/group/MFQWKKT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MG37", "url": "https://www.orthodb.org/?gene=F1MG37", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11214", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11214", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11214:SF93", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11214:SF93", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01762", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01762", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2022854", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022854", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-913709", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002685725", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685725", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MG37", "url": "https://www.uniprot.org/uniprotkb/F1MG37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG37-1", "url": "https://www.uniprot.org/uniprotkb/F1MG37-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLWKRTVYKSVCLSLALLVAVTVFQRSLTPSQFLQEPPPASLRQQKAQKPSGLLVNPDSFWKSAKEVVTPTPVVSRRPQAWDVNTTNCSANVNLTHQSWFQGLEPHFQQFLLYRHCRYFPMLLNHPEKCSGDVYLLVVVKSIIAQHDRREAIRQTWGREQESAGRGRGAVRTLFLLGKASKPEEQSHYQQLLAYEDRIYGDILQWDFLDSFFNLTLKEIHFLKWLDIYCPDVRFVFKGDDDVFVNPTNLLEFLADRRPQEDLFVGDILHHARPIRRKDSKYYIPGILYNQNSYPPYAGGGGFLMAGGLAQRLHHSCDTLELYPIDDVFLGMCLEVLGVRPMAHEGFKTFGISRNRNSRMNKEPCFFRSMLVVHKLLPTELLAMWELVHGNLTCSRKLQVL", "length": 401, "header": "tr|F1MG37-1|F1MG37_BOVIN Isoform 1 of Hexosyltransferase OS=Bos taurus OX=9913 GN=B3GNT7 PE=3 SV=3 CANONICAL=F1MG37-1" }, "isoforms": [ { "isoform_ac": "F1MG37-1", "url": "https://www.uniprot.org/uniprotkb/F1MG37/entry", "sequence": { "sequence": "MSLWKRTVYKSVCLSLALLVAVTVFQRSLTPSQFLQEPPPASLRQQKAQKPSGLLVNPDSFWKSAKEVVTPTPVVSRRPQAWDVNTTNCSANVNLTHQSWFQGLEPHFQQFLLYRHCRYFPMLLNHPEKCSGDVYLLVVVKSIIAQHDRREAIRQTWGREQESAGRGRGAVRTLFLLGKASKPEEQSHYQQLLAYEDRIYGDILQWDFLDSFFNLTLKEIHFLKWLDIYCPDVRFVFKGDDDVFVNPTNLLEFLADRRPQEDLFVGDILHHARPIRRKDSKYYIPGILYNQNSYPPYAGGGGFLMAGGLAQRLHHSCDTLELYPIDDVFLGMCLEVLGVRPMAHEGFKTFGISRNRNSRMNKEPCFFRSMLVVHKLLPTELLAMWELVHGNLTCSRKLQVL", "length": 401, "header": "tr|F1MG37-1|F1MG37_BOVIN Isoform 1 of Hexosyltransferase OS=Bos taurus OX=9913 GN=B3GNT7 PE=3 SV=3 CANONICAL=F1MG37-1" }, "locus": { "chromosome": "2", "start_pos": 119178811, "end_pos": 119175477, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000051973.4", "url": "https://www.ensembl.org/id/ENSBTAT00000051973.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048335.3", "url": "https://www.ensembl.org/id/ENSBTAP00000048335.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 72, "start_aa": "Thr", "end_pos": 72, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr72", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538799", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538799", "resource": "KEGG Pathway" }, { "id": "R-BTA-2022854", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2022854", "resource": "Reactome", "description": "Keratan sulfate biosynthesis" }, { "id": "R-BTA-913709", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-913709", "resource": "Reactome", "description": "O-linked glycosylation of mucins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BKI9-1", "protein_name": "Hexosyltransferase", "gene_name": "B3GNT7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLWKRTVYKSVCLALALLVAVTVFQRSLTPSQFLQEPPPPTLGLQKTQKPSGHLVNPDSFWKNPKDVVTPTPMVSRGPQAWDVTTTNCSANINLTQQPWFQGLEPHFQQFLFYRHCRYFPMLLNHPEKCERGVYLLVVVKSVITQHDRREAIRQTWGRERASAGRGLGAVRTLFLLGTASKQEERAHYQQLLAYEDRIYGDILQWDFLDSFFNLTLKEIHFLKWLDIYCPSVPFIFKGDDDVFVNPTNLLEFLADRRPQEDLFVGDVLQHARPIRKKDNKYYIPGILYSQASYPPYAGGGGFLMAGGLARRLRHACDTLELYPIDDVFLGMCLEVLGVRPTAHEGFKTFGISRNRNSRMNKEPCFFRSMLVVHKLLPTELLAMWRLVHGNLTCSRKLQVL", "length": 401 }, "evidence": [ { "id": "F1MG37", "url": "https://omabrowser.org/oma/group/F1MG37/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YSJ1-1", "protein_name": "Hexosyltransferase", "gene_name": "B3GNT7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSLPPPVSSPHLPSRPCRRKTIYKTVCLSFLLVITVTVLQRGMAPSQFLQGQQQKELPTPEPLKTQKRDNSFSITSNFWKSKKEKAPSKEEEGGMTERQVKSWDITTTNCSANQNLSRVDWFKGLEPNFQQFLLYRHCRYFPMLINHPEKCSGDVYLLIVVKSIITQHDRREAIRRTWGKEKEVEGKKIRTLFLLGTASKEEERANYQKLLDYENHIYGDILQWDFLDSFFNLTLKEVHFLKWLNIYCDNIRFIFKGDDDVFVSPDNILEFLEDKKEGEDVFVGDVLYKARPIRKKENKYYIPSALYNKSIYPPYAGGGGFVMDGPLAKRLHKASETLELYPIDDVFLGMCLEVLKVSPVGHEGFKTFGIVRNKNSKMNKEPCFFRSMLVVHKLLPPDLIQMWDLVHSNLTCSRKLNVL", "length": 419 }, "evidence": [ { "id": "F1MG37", "url": "https://omabrowser.org/oma/group/F1MG37/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q66H69-1", "protein_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7", "gene_name": "B3gnt7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLWKKTLYKSVCLALALLVAVTVFQRSVTPGQFLQDPLPPTLGPPKTGSLVNPNSFWKSSKDVVAPTPTVPRGPQVWDVVTTNCSINVNLTHQPWFQNLEPHFRQFLAYQHCRYFPMLLNHPEKCAGDVYLLVVVKSVITQHDRREVIRQTWGHEWESAGPDRGAVRTLFLLGTASKQEERTHYQQLLAYEDRLYGDILQWDFLDSFFNLTLKEIHFLKWLDIYCPNVPFIFKGDDDVFVNPTNLLEFLSDRQPQENLFVGDVLKHARPIRKKDNKYYIPAVMYSKATYPPYAGGGGFLMSGSLARQLHHACDTLELFPIDDVFLGMCLEVLGVKPTGHEGFKTFGISRVRGSRMNKEPCFYRSMLVVHKLLPAELLAMWDLVHSNLTCSLKFQVL", "length": 397 }, "evidence": [ { "id": "F1MG37", "url": "https://omabrowser.org/oma/group/F1MG37/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8K0J2-1", "protein_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7", "gene_name": "B3gnt7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLWKKTLYKSVCLALALLVAVTVFQRSVTPGQFLQDPLPPTPGPAKTGNLVNPNSFWKSSKDVAAPTPTVPRGPQVWDVITTNCSININLTHQPWFQSLEPHFRQFLAYRHCRYFPMLLNHPEKCAGDVYMLVVVKSVITQHDRREVIRQTWGHEWESAGLGRGAVRTLFLLGTASKQEERTHYQQLLAYEDRLYADILQWDFLDSFFNLTLKEIHFLKWLDIYCPNVPFVFKGDDDVFVNPTNLLEFLSDRQPQENLFVGDVLKHARPIRKKDNKYYIPAVMYGKATYPPYAGGGGFLMSGSLARQLHHACDTLELFPIDDVFLGMCLEVLGVKPTGHEGFKTFGISRVRSSRMNKEPCFYRAMLVVHKLLPAELLAMWDLVHSNLTCSVKFQVL", "length": 397 }, "evidence": [ { "id": "F1MG37", "url": "https://omabrowser.org/oma/group/F1MG37/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NFL0-1", "protein_name": "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7", "gene_name": "B3GNT7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLWKKTVYRSLCLALALLVAVTVFQRSLTPGQFLQEPPPPTLEPQKAQKPNGQLVNPNNFWKNPKDVAAPTPMASQGPQAWDVTTTNCSANINLTHQPWFQVLEPQFRQFLFYRHCRYFPMLLNHPEKCRGDVYLLVVVKSVITQHDRREAIRQTWGRERQSAGGGRGAVRTLFLLGTASKQEERTHYQQLLAYEDRLYGDILQWGFLDTFFNLTLKEIHFLKWLDIYCPHVPFIFKGDDDVFVNPTNLLEFLADRQPQENLFVGDVLQHARPIRRKDNKYYIPGALYGKASYPPYAGGGGFLMAGSLARRLHHACDTLELYPIDDVFLGMCLEVLGVQPTAHEGFKTFGISRNRNSRMNKEPCFFRAMLVVHKLLPPELLAMWGLVHSNLTCSRKLQVL", "length": 401 }, "evidence": [ { "id": "F1MG37", "url": "https://omabrowser.org/oma/group/F1MG37/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "UDP-glycosyltransferase activity", "id": "GO:0008194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008194", "evidence": [ { "database": "UniProtKB", "id": "F1MG37", "url": "https://www.uniprot.org/uniprotkb/F1MG37" } ], "pmid": "" }, { "name": "N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity", "id": "GO:0008532", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008532", "evidence": [ { "database": "UniProtKB", "id": "F1MG37", "url": "https://www.uniprot.org/uniprotkb/F1MG37" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F1MG37", "url": "https://www.uniprot.org/uniprotkb/F1MG37" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "keratan sulfate proteoglycan biosynthetic process", "id": "GO:0018146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018146", "evidence": [ { "database": "UniProtKB", "id": "F1MG37", "url": "https://www.uniprot.org/uniprotkb/F1MG37" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 391, "end_pos": 393, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" }, { "start_pos": 88, "end_pos": 90, "annotation": "n_glycosylation_sequon" }, { "start_pos": 94, "end_pos": 96, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-2025724", "name": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MG37-1", "F1MSS4-1", "Q5EA01-1" ], "evidence": [ { "id": "R-BTA-2025724", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2025724" } ] }, { "id": "R-BTA-914010", "name": "B3GNT6 transfers GlcNAc to Tn antigen", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q17QZ8-1", "A0AAA9TA32-1", "F1MG37-1", "F1MGN7-1", "F1MSS4-1" ], "evidence": [ { "id": "R-BTA-914010", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-914010" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9TA32", "gene_name": "B3GNT5", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "A0AAA9TA32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA32" } ] } ] }, { "uniprot_ac": "F1MG37", "gene_name": "B3GNT7", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F1MG37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG37" } ] } ] }, { "uniprot_ac": "F1MGN7", "gene_name": "B3GNT6", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F1MGN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGN7" } ] } ] }, { "uniprot_ac": "F1MSS4", "gene_name": "B3GNT4", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "F1MSS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSS4" } ] } ] }, { "uniprot_ac": "Q17QZ8", "gene_name": "B3GNT9", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q17QZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QZ8" } ] } ] }, { "uniprot_ac": "Q5EA01", "gene_name": "B4GAT1", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q5EA01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EA01" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MG37-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 401, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MG37-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MG37" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 72 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 214, "end_pos": 216 }, { "start_pos": 391, "end_pos": 393 }, { "start_pos": 85, "end_pos": 87 }, { "start_pos": 88, "end_pos": 90 }, { "start_pos": 94, "end_pos": 96 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MG43-1", "uniprot_ac": "F1MG43", "uniprot_id": "F1MG43_BOVIN", "mass": { "chemical_mass": 36990.0, "monoisotopic_mass": 36990.0 }, "refseq": { "ac": "NP_001376952", "name": "olfactory receptor 6Y1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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[provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377615" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MG53", "url": "https://www.uniprot.org/uniprotkb/F1MG53#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MG53", "url": "https://www.uniprot.org/uniprotkb/F1MG53" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR8I2", "url": "https://www.uniprot.org/uniprotkb/F1MG53", "locus": { "chromosome": "15", "start_pos": 79025137, "end_pos": 79024208, "strand": "-", "evidence": 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"id": "bta:100300545", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100300545", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MPYAIGF", "url": "https://omabrowser.org/oma/group/MPYAIGF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MG53", "url": "https://www.orthodb.org/?gene=F1MG53", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377615", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MG53", "url": "https://www.uniprot.org/uniprotkb/F1MG53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG53-1", "url": "https://www.uniprot.org/uniprotkb/F1MG53-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGNNFTEVTFFILSGFANHPELHVSLFMMFLFIYLITVLGNLGLILIIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVNLQSIQKTISFVACFVQMYFFVGLVCSECFLLGSMAYDRYVAICNPLLYPVVMSQKVCRWLGVMPYMMGFTNSLVSICVISRLAFCEASINHFFCDTTALLALSCVDAFSTEMVIFVLAGFTLLSSLFIITVTYIAIISAILQIRSAAGREKAFSTCVSHIVGVTVFYGSLIFTYLQPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLKAFQKLFP", "length": 309, "header": "tr|F1MG53-1|F1MG53_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8I2 PE=3 SV=3 CANONICAL=F1MG53-1" }, "isoforms": [ { "isoform_ac": "F1MG53-1", "url": "https://www.uniprot.org/uniprotkb/F1MG53/entry", "sequence": { "sequence": "MAGNNFTEVTFFILSGFANHPELHVSLFMMFLFIYLITVLGNLGLILIIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVNLQSIQKTISFVACFVQMYFFVGLVCSECFLLGSMAYDRYVAICNPLLYPVVMSQKVCRWLGVMPYMMGFTNSLVSICVISRLAFCEASINHFFCDTTALLALSCVDAFSTEMVIFVLAGFTLLSSLFIITVTYIAIISAILQIRSAAGREKAFSTCVSHIVGVTVFYGSLIFTYLQPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLKAFQKLFP", "length": 309, "header": "tr|F1MG53-1|F1MG53_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR8I2 PE=3 SV=3 CANONICAL=F1MG53-1" }, "locus": { "chromosome": "15", "start_pos": 79025134, "end_pos": 79024208, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052309.3", "url": "https://www.ensembl.org/id/ENSBTAT00000052309.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050634.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050634.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100300545", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100300545", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LHA4-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100768151", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAENNFTEITFFVLSGFSDQPELQVSLFLIFLCIYLFTVLGNLGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCSECFLLGSMAYDRYAAICNPLLYSVIMSQKVCNCLGVIPYVIGFTNSLVSICVISSLAFCDSYINHFFCDTTALLALSCVDAFRTELVIFALAGFTLLSSLLIITSTYIIIISAILRIQSADGRWKAFSTCASHLIGVTVFYGSLIFTYLTPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLRVLHRKHFL", "length": 310 }, "evidence": [ { "id": "F1MG53", "url": "https://omabrowser.org/oma/group/F1MG53/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A2AVB5-1", "protein_name": "Olfactory receptor", "gene_name": "Or8i2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTENNFTKVTVFMFSGFSDHPELQVSLFLIFLFIYLFTVWGNIGLILLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKAVVDFQSTQKSISFVGCFVQMYFFVGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPYINHFFCDTTALLALSCVDAFSTELVIFVLAGFTLLSSLLIITFTYVTIISAILRIQSAAGRWKAFSTCASHLTGVTVFYGSLIFTYLQPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLRVIHRKHLL", "length": 310 }, "evidence": [ { "id": "F1MG53", "url": "https://omabrowser.org/oma/group/F1MG53/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZTQ7-1", "protein_name": "Olfactory receptor", "gene_name": "Or8i2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTENNFTKVTVFMLSGFSDHPELQVSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPYINHFFCDTTALLALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLRVIDRKLFL", "length": 310 }, "evidence": [ { "id": "F1MG53", "url": "https://omabrowser.org/oma/group/F1MG53/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RWR6-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100622779", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTGNNFTEVTFFILSGFANRTELQIRLFLMFLFIYLFTVLGNLGLIVLIKIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVNFLSKQKTISFIGCFVQMYFFVGLVCSECFLLGSMAYDRYVAICNPLLYSVVMSQKVCNWLGAMPYTVGFTNSLISICVISSLAFCDISINHFFCDTTALLALSCVDIFSTERVIFVLAGFTVLSSLFIIITTYIAIISAILKIRSAAGRQAFSTCASHLMGVAIFYGSLIFTYLQPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLRVMQRKHFA", "length": 309 }, "evidence": [ { "id": "F1MG53", "url": "https://omabrowser.org/oma/group/F1MG53/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8N0Y5-1", "protein_name": "Olfactory receptor 8I2", "gene_name": "OR8I2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGNNFTEVTVFILSGFANHPELQVSLFLMFLFIYLFTVLGNLGLITLIRMDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVNFQSNRRSISFVGCFVQMYFFVGLVCCECFLLGSMAYNRYIAICNPLLYSVVMSQKVSNWLGVMPYVIGFTSSLISVWVISSLAFCDSSINHFFCDTTALLALSCVDTFGTEMVSFVLAGFTLLSSLLIITVTYIIIISAILRIQSAAGRQKAFSTCASHLMAVTIFYGSLIFTYLQPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLRVIHRKLFP", "length": 310 }, "evidence": [ { "id": "F1MG53", "url": "https://omabrowser.org/oma/group/F1MG53/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MG53", "url": "https://www.uniprot.org/uniprotkb/F1MG53" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1MG53", "url": "https://www.uniprot.org/uniprotkb/F1MG53" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "F1MG53", "url": "https://www.uniprot.org/uniprotkb/F1MG53" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MG53", "url": "https://www.uniprot.org/uniprotkb/F1MG53" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "F1MG53", "url": "https://www.uniprot.org/uniprotkb/F1MG53" } ], "pmid": "" }, { "name": "sensory perception of smell", "id": "GO:0007608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007608", "evidence": [ { "database": "UniProtKB", "id": "F1MG53", "url": "https://www.uniprot.org/uniprotkb/F1MG53" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MG53-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 309, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MG53-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MG53" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MG53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG53" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 289, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 263, "end_pos": 265 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MG58-1", "uniprot_ac": "F1MG58", "uniprot_id": "F1MG58_BOVIN", "mass": { "chemical_mass": 30664.0, "monoisotopic_mass": 30664.0 }, "refseq": {}, "gene_names": [ { "name": "INSYN1", "type": "recommended", "evidence": [ { "id": "F1MG58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG58" } ] } ], "protein_names": [ { "name": "Inhibitory synaptic factor 1", "type": "recommended", "evidence": [ { "id": "F1MG58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG58/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MG58", "url": "https://www.uniprot.org/uniprotkb/F1MG58" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INSYN1", "url": "https://www.uniprot.org/uniprotkb/F1MG58", "locus": { "chromosome": "10", "start_pos": 20546454, "end_pos": 20559337, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025803", "url": "https://www.ensembl.org/id/ENSBTAG00000025803" } ] } } ], "crossref": [ { "id": "F1MG58", "url": "https://alphafold.ebi.ac.uk/entry/F1MG58", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025803", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025803", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR027997", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027997", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MG58", "url": "https://www.orthodb.org/?gene=F1MG58", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15917", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15917", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15917:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15917:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15252", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15252", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MG58", "url": "https://www.uniprot.org/uniprotkb/F1MG58", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG58-1", "url": "https://www.uniprot.org/uniprotkb/F1MG58-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNIRGTPDLGQPSDDPSSGGERERIRQRMKMVIGQLEDILRELKEVAKELREVVSQIDKLTSDFDFELEPDDWTTATVSSTSSSDKAGVGGPFDLGHLDFMTADILSDSWEFCSFLDISTPSDSVDGPESTRPGAGPDYRLMNGGLPVPNGPRVETPDSSSEEAFSAGPVKGQLPQRTPGTRERVRFSDKVLYHALCCDDEEGDGEEEAAEEEGGLSPEPAHTEAPAGPLKPSPAPYKPRRSPLTGRRSGPTSVPEQTRRVTRNSSTQTVSDKSTQTSTVVEAG", "length": 284, "header": "tr|F1MG58-1|F1MG58_BOVIN Isoform 1 of Inhibitory synaptic factor 1 OS=Bos taurus OX=9913 GN=INSYN1 PE=3 SV=2 CANONICAL=F1MG58-1" }, "isoforms": [ { "isoform_ac": "F1MG58-1", "url": "https://www.uniprot.org/uniprotkb/F1MG58/entry", "sequence": { "sequence": "MNIRGTPDLGQPSDDPSSGGERERIRQRMKMVIGQLEDILRELKEVAKELREVVSQIDKLTSDFDFELEPDDWTTATVSSTSSSDKAGVGGPFDLGHLDFMTADILSDSWEFCSFLDISTPSDSVDGPESTRPGAGPDYRLMNGGLPVPNGPRVETPDSSSEEAFSAGPVKGQLPQRTPGTRERVRFSDKVLYHALCCDDEEGDGEEEAAEEEGGLSPEPAHTEAPAGPLKPSPAPYKPRRSPLTGRRSGPTSVPEQTRRVTRNSSTQTVSDKSTQTSTVVEAG", "length": 284, "header": "tr|F1MG58-1|F1MG58_BOVIN Isoform 1 of Inhibitory synaptic factor 1 OS=Bos taurus OX=9913 GN=INSYN1 PE=3 SV=2 CANONICAL=F1MG58-1" }, "locus": { "chromosome": "10", "start_pos": 20558283, "end_pos": 20546680, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036489.6", "url": "https://www.ensembl.org/id/ENSBTAT00000036489.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036346.5", "url": "https://www.ensembl.org/id/ENSBTAP00000036346.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "GABA-ergic synapse", "id": "GO:0098982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982", "evidence": [ { "database": "UniProtKB", "id": "F1MG58", "url": "https://www.uniprot.org/uniprotkb/F1MG58" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "F1MG58", "url": "https://www.uniprot.org/uniprotkb/F1MG58" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "inhibitory postsynaptic potential", "id": "GO:0060080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060080", "evidence": [ { "database": "UniProtKB", "id": "F1MG58", "url": "https://www.uniprot.org/uniprotkb/F1MG58" } ], "pmid": "" }, { "name": "postsynaptic specialization organization", "id": "GO:0099084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099084", "evidence": [ { "database": "UniProtKB", "id": "F1MG58", "url": "https://www.uniprot.org/uniprotkb/F1MG58" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MG58-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 284, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MG58-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MG58" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 264, "end_pos": 266 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MG71-1", "uniprot_ac": "F1MG71", "uniprot_id": "F1MG71_BOVIN", "mass": { "chemical_mass": 134433.0, "monoisotopic_mass": 134433.0 }, "refseq": { "ac": "XP_024833571", "name": "transcriptional activator MN1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833571" }, "gene_names": [ { "name": "MN1", "type": "recommended", "evidence": [ { "id": "F1MG71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG71" } ] }, { "name": "MN1", "type": "synonym", "evidence": [ { "id": "XP_024833571", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833571" } ] } ], "protein_names": [ { "name": "MN1 proto-onco, transcriptional regulator", "type": "synonym", "evidence": [ { "id": "F1MG71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG71/entry#names_and_taxonomy" } ] }, { "name": "transcriptional activator MN1", "type": "synonym", "evidence": [ { "id": "XP_024833571", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833571" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MG71", "url": "https://www.uniprot.org/uniprotkb/F1MG71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MN1", "url": "https://www.uniprot.org/uniprotkb/F1MG71", "locus": { "chromosome": "17", "start_pos": 67174979, "end_pos": 67221832, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010464", "url": "https://www.ensembl.org/id/ENSBTAG00000010464" } ] } } ], "crossref": [ { "id": "ENSBTAG00000010464", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010464", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "786290", "url": "https://www.ncbi.nlm.nih.gov/gene/786290", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR037644", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037644", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:786290", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786290", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QESAWFS", "url": "https://omabrowser.org/oma/group/QESAWFS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MG71", "url": "https://www.orthodb.org/?gene=F1MG71", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15821", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15821", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15821:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15821:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "XP_024833571", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833571", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MG71", "url": "https://www.uniprot.org/uniprotkb/F1MG71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MG71-1", "url": "https://www.uniprot.org/uniprotkb/F1MG71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFGLDQFEPQINSRNAGQGERNFNEAGLSMNAHFKAPAFHAGGPPGPVDPAMSGLGEPPILGMNMEPYGFHARSHSELHAGGLQAQPVHGFFGGQQPHHGHPGGHHPHQHHPHFGGNFGGPDPGASCLHGGRLLGYGGAAGGLGSQPPFTEGYDHMAESQGPESFGPQRPGNLPDFHSSGASGHAVPAPCLPLDQSPNRAASFHGLPASGGSDSHSLEPRRVANQGAVDSLEYNYPGEPPSGHFDMFSPSDSEGQLPHYAAGRQVPGGSFPGASAMPRAAGMVGLSKMHAQQQQQQQQQQQQQQQQQQHGVFFERFGGTRKMPVGLEPGVGSRHPLMQPPQQAPPPPQQPPPQQAPPPPQQPPPQQPPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPMLPNQHAQFEYPIHRLENRSMHPYSEPVFNMQQAPNQRLQHFDAPPYMNVAKRPRFDFPGSAGVDRCASWNGSMHNGALDNHLSPSAYSGLPGEFTPPVPDSFPSGPPLQHPAPDHPSLQQQQQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGHPGDVGQGGLVHSGPVGGLGQPNFERDSGGAGAGRLGTFEPQAQHLAQESAWFPGPHPPPGDLLPRRMGGSGLPSDCGPHDPGLAPPPPPGGSGVLFRGSLQEPLRMPGEGHVPGLPSPGLQFGGSLASLGQLQSPGAGVGLPSAPSERRPQPPDFTAPALGGQPGFPFGAANRQATPHSGPGVNSPPSAGGGGGSTGGGGGAGGGGAYPPQPDFQPSQRTSASKLGALSLGSFNKPSSKDNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNPPEGKRKLSQNETDGAAVAGNPGSDYFPGGTAPGAPGPGGPSGTSSSGSKASGPPNPPAQGDGTSLSPNYTLESTSGNDGKPVPGGGGRGRGRRKRDSGHVSPGTFFDKYSAASAPDSGGAPGVSPGQQQAPGAAVGGNSGEVRGAPTPHEKALTSPSWGKGAELLLGDQPDLMASLDGGAKSDSSSPHVGEFASDEVSTSYANEDEVSSSSDNPPALAKASRSPLVTGSPKLPPRGVGTGEHGPKAPPPPLGLGILSTSTSTPDSYGGGGTGHPGTPGLEQVRTPTSSGGAPPPDEIHPLEILQAQIQLQRQQFSISEDQPLGLKGGKKGECAVGASGAQNGDSELGSCCSEAVKSAMSTIDLDSLMAEHSATWYMPADKALVDGTEEDKTLAPWEKAKPQNPNSKEAHDLPANKASAPQPGSHLQCLSVHCTDDVGDAKARASVPTWRSLHSDISNRFGTFVAALT", "length": 1309, "header": "tr|F1MG71-1|F1MG71_BOVIN Isoform 1 of MN1 proto-onco, transcriptional regulator OS=Bos taurus OX=9913 GN=MN1 PE=4 SV=3 CANONICAL=F1MG71-1" }, "isoforms": [ { "isoform_ac": "F1MG71-1", "url": "https://www.uniprot.org/uniprotkb/F1MG71/entry", "sequence": { "sequence": "MFGLDQFEPQINSRNAGQGERNFNEAGLSMNAHFKAPAFHAGGPPGPVDPAMSGLGEPPILGMNMEPYGFHARSHSELHAGGLQAQPVHGFFGGQQPHHGHPGGHHPHQHHPHFGGNFGGPDPGASCLHGGRLLGYGGAAGGLGSQPPFTEGYDHMAESQGPESFGPQRPGNLPDFHSSGASGHAVPAPCLPLDQSPNRAASFHGLPASGGSDSHSLEPRRVANQGAVDSLEYNYPGEPPSGHFDMFSPSDSEGQLPHYAAGRQVPGGSFPGASAMPRAAGMVGLSKMHAQQQQQQQQQQQQQQQQQQHGVFFERFGGTRKMPVGLEPGVGSRHPLMQPPQQAPPPPQQPPPQQAPPPPQQPPPQQPPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPMLPNQHAQFEYPIHRLENRSMHPYSEPVFNMQQAPNQRLQHFDAPPYMNVAKRPRFDFPGSAGVDRCASWNGSMHNGALDNHLSPSAYSGLPGEFTPPVPDSFPSGPPLQHPAPDHPSLQQQQQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGHPGDVGQGGLVHSGPVGGLGQPNFERDSGGAGAGRLGTFEPQAQHLAQESAWFPGPHPPPGDLLPRRMGGSGLPSDCGPHDPGLAPPPPPGGSGVLFRGSLQEPLRMPGEGHVPGLPSPGLQFGGSLASLGQLQSPGAGVGLPSAPSERRPQPPDFTAPALGGQPGFPFGAANRQATPHSGPGVNSPPSAGGGGGSTGGGGGAGGGGAYPPQPDFQPSQRTSASKLGALSLGSFNKPSSKDNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNPPEGKRKLSQNETDGAAVAGNPGSDYFPGGTAPGAPGPGGPSGTSSSGSKASGPPNPPAQGDGTSLSPNYTLESTSGNDGKPVPGGGGRGRGRRKRDSGHVSPGTFFDKYSAASAPDSGGAPGVSPGQQQAPGAAVGGNSGEVRGAPTPHEKALTSPSWGKGAELLLGDQPDLMASLDGGAKSDSSSPHVGEFASDEVSTSYANEDEVSSSSDNPPALAKASRSPLVTGSPKLPPRGVGTGEHGPKAPPPPLGLGILSTSTSTPDSYGGGGTGHPGTPGLEQVRTPTSSGGAPPPDEIHPLEILQAQIQLQRQQFSISEDQPLGLKGGKKGECAVGASGAQNGDSELGSCCSEAVKSAMSTIDLDSLMAEHSATWYMPADKALVDGTEEDKTLAPWEKAKPQNPNSKEAHDLPANKASAPQPGSHLQCLSVHCTDDVGDAKARASVPTWRSLHSDISNRFGTFVAALT", "length": 1309, "header": "tr|F1MG71-1|F1MG71_BOVIN Isoform 1 of MN1 proto-onco, transcriptional regulator OS=Bos taurus OX=9913 GN=MN1 PE=4 SV=3 CANONICAL=F1MG71-1" }, "locus": { "chromosome": "17", "start_pos": 67221633, "end_pos": 67175983, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052340.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052340.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050627.3", "url": "https://www.ensembl.org/id/ENSBTAP00000050627.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 394, "start_aa": "Thr", "end_pos": 394, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr394", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:786290", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786290", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B8JKI7-1", "protein_name": "Transcriptional activator MN1", "gene_name": "mn1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFELEQFGPQINNRNFGHTEKNFNKPKVSMNSHYKSPGFHTGGSQNTAEPGMGPLNETPVIEMNINMSRGEQYGGFQRGHSELHTGNLQQQPSMHGFFNPQQPHNHSHGHQTHPHQHFGGNFGPEPGSSCLHSGRVMGYNSSMGLQQGFTEGFDSLSEGQSADGGFSQQQQRTSSMSDFQHHGPPSGNHPVPAPCLPLDQSPNRAASFHGLSSSSSSSESHNLEPRRMPPPAAVEGLDYSFPNEPSSRHFDVPVYSPSESDSQLSHFGTGRQVPGSNFPGNTGLSRAPGMQGIAKEHPHAPPQQQQPSAQHSVFFERFGGGRKIPVGIEPGARHPLMQQQQPGLIGRQNTCPPSLPQPPLSETASANVGMQEGGVMMPGQHNQFEYPIHRPENRRIHSYGDPIFNMQQQPPPPQQPPNQRLQHFDSPYLNMGKRPRFDFPNATHGRESCGSWNSAMENNLSPAAYPGLPGEFTPPVTDGFSTGPSLQLTGSEQQSMQQQQNAAMMIKQMASRSQQQRMRQPSLQQLGHHNDVSQGPLGPGGPVGGMPQSSFERENGGRMVNFDGRSPHMTMESGWFPGPHPPGEMLGHRMGSSGEMGDRDIQQNGPGMMFRAGVSGMGMQESMRVPGEGHVQPLLSPNIHSQFNSGMGSLSQMQSPSAGVGLPNTPSERRSNDFPGPPMGGPSQFQYGGSNRQGASHGNSQGVNTSPGSFTCQSDFPTSQRSSVSKLGGLSLGNFSKTNGKDNVFGQSCLAALSTACQNMIASLGAPNLNVTFNKKTQAEGKRKLSQTEQDLNNSAVNGTGNTGTEYFPSLTAPQNGQMPPAGNSNAKPLSQNQTVQGEASALSPNFNMDTTPCSEGKAATGSGRGRGRRKRDSGHVSPGIFFPSENSNPVVSPSQQVSSAERSTGTPHEKPHTSPSWGKGGDLLLGDQSDLMSSLDSGIQSASKSEVCSPRMDFTDDAVVTHYSNEDEVSSSSDAQSSVKPGCSPLLGSPKMPNGLMSGQKGQGLSNQTTSTSDGFGGAGHPGTPGMEQVRTPSSTSGQDEIHPLEILQAQIQLQRQQFSISEDQPLAVNNNKKSSELGDGELASCGPDAEKSSVGTIDLDTLMAEQHATWYVPSDKCLLEDSEEEKSTWEKNKAQATIKEEADLTQNKSGGGAGSSGTAGGMGSHLQCLSVHCTDELGESKGRGGPVPSWRSLHSDISNRFGTFVAALT", "length": 1211 }, "evidence": [ { "id": "F1MG71", "url": "https://omabrowser.org/oma/group/F1MG71/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3YWE6-1", "protein_name": "Transcriptional activator MN1", "gene_name": "Mn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFGLDQFEPQINSRHAGQGEGNFNEAGLSMNAHFKAPAFHAGPPTGPVDPAISALGEPPILGLNMEPYGFHARSHSELHAGGLQAQPVHGFFGGQQPHHSHPGGHHPHQHHPHFGGNFGGPDPGASCLHGGRLLGYGGAAGGLGSQPPFAESYEHMAESQGPEGFGPQRPGNLPDFHSSGTSGHAVPAPCLPLDQSPNRAASFHGLSASSGSDSHSLEPRRVTNQGAVDSLEYNYPSEPPSGHFDMFSPSDSEGQLPHYAAGRQVPGGAFPGASAMPRASGMVGLSKMHSQPPQPPPQQQQPQHGVFFERFGGARKMPVGLEPAVGSRHPLMQPPQQAPPPPQQPPPQQQPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPMLPSQHAQFEYPIHRLENRSMHPYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPRFDFPGSAGVDRCASWNGSMHNGTLDNQLSPSAYPGLPGEFTPPVPDSFSSGPPLQHPGPDHQSLQQQQQQQQQQQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGHPGDVGQGGLVHGGSVGGLAQTNFEREGGSAGAGRLSGFEQQAPHLAQESAWFPGPHPPGDLLPRRMGGAGLPTDCGPHDPALAPPPAPGGSGVLFRGSLQEPLRMPGEGHVPALASPGLQFGGSLAGLGQLQSPGAGVGLPNAPSERRPPPPDFPAPALGGQPGFPFGSGSRQATPHSAPGVNSPPSAGSGSSGAGGGAYPPQPDFQPSQRNSASKLGALSLGSFNKPSSKDNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNPPEGKRKLSQNEPDSAVAAGNPGSDYFPGGTTPGAPGPGGPSGTSGGGSKASGPPNPPIQGDSTSLSPNYTLESTSGNDGKPVPGGSGRGRGRRKRDSGHVSPGTFFDKYSTAPDSGGAPGVSPGQQQAPGSAAGGSSVNEARGPTPHEKALTSPSWGKGAELLLGDQPDLMASLDSTAKSDGSSPHVGEFASDEVSTSYANEDEVSSSSDNTTALAKASRSPLVTSSPKLPPRGVGAGEHTPKASALGLGILSTSTSTPDSYGGGVGTGHPGTPGLEQVRTPTSSSGAQPPDEIHPLEILQAQIQLQRQQFSISEDQPLGLKGSKKAECAVGASGAQNGDSELGSCCSEAVKSAMSTIDLDSLMAEHSTTWYMPPDKALVDGGDEDKTLAPWEKAKSQNPNNKEAHDHPTNKASATQPGSHLQCLTVHCTDGDPKARTSVPTWRSLHSDISNRFGTFVAALT", "length": 1297 }, "evidence": [ { "id": "F1MG71", "url": "https://omabrowser.org/oma/group/F1MG71/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D4AAP6-1", "protein_name": "MN1 proto-oncogene, transcriptional regulator", "gene_name": "Mn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFGLDQFEPQINSRHAGQGEGNFNEAGLSMNAHFKAPAFHAGPPPGPVDPAISALGEPPILGLNMEPYGFHARGHSELHAGGLQAQPVHGFFGGQQPHHSHPGGHHPHQHHPHFGGNFGGPDPGASCLHGGRLLGYGGAASGLGSQPPFAESYEHMAESQGPEGFGPQRPGNLPDFHSSGTSGHAVPAPCLPLDQSPNRAASFHGLSASSGSDSHSLEPRRVTNQGAVDSLEYNYPSEPPSGHFDMFSPSDSEGQLPHYAAGRQVPGGAFPGASAMPRASGMVGLSKMHGQPPQPPPPQQQPQHGVFFERFGGARKMPVGLEPAVGSRHPLMQPPQQAPPPPQQQPQQQQPPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPMLPSQHAQFEYPIHRLENRSMHPYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPRFDFPGSTGVDRCASWNGSMHNGTLDNQLSPSAYPGLPGEFTPPVPDSFPSGPPLQHPGPDHQSLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQHQRLRQPNLAQLGHPGDVGQGGLVHGGSVSGLAQTNFEREGGSTGAGRLGGFEQQAPHLAQESAWFPGPHPPGDLLPRRMGSAGLPADCGPHDPGLAPPPAPGGSGVLFRGSLQEPLRMPGEGHVPALASPGLQFGSSLAGLGQLQSPGAGVGLPNAPSERRPPPPDFPAPALGGQPGFPFGSGSRQATPHSAPGVNSPPSAGAGSGSSGAAGGAYPPQPDFQSSQRNSASKLGALSLGSFNKPSSKDNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNPPEGKRKLSQNEPDSAVAAGNPGSDYFPGGTTPGAPGPGGPSGTSGGGSKASGPPNPPIQGDSTSLSPNYTLESTSGSDGKPVPGGSGRGRGRRKRDSGHVSPGTFFDKYSAAPDSGGAPGVSPGQQQAPGSAAGGSSVNEARGPTPHEKALTSPSWGKGAELLLGDQPDLMASLDSTAKSDGSSPHVGEFASDEVSTSYANEDEVSSSSDNTTALAKASRSPLVTSSPKLPPRGVGAGEHTPKASALGLGILSTSTSTPDSYGGGVGTGHPGTPGLEQVRTPTSSSGAPPPDEIHPLEILQAQIQLQRQQFSISEDQPLGLKGSKKTECAVGASGAQNGDSELGSCCSEAVKSAMSTIDLDSLMAEHSTTWYMPPDKALVDGGDDDKTLAPWEKAKSQNPNNKEVHDHPTNKASATQPGSHLQCLTVHCTDGDPKARTSVPTWRSLHSDISNRFGTFVAALT", "length": 1304 }, "evidence": [ { "id": "F1MG71", "url": "https://omabrowser.org/oma/group/F1MG71/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q10571-1", "protein_name": "Transcriptional activator MN1", "gene_name": "MN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFGLDQFEPQVNSRNAGQGERNFNETGLSMNTHFKAPAFHTGGPPGPVDPAMSALGEPPILGMNMEPYGFHARGHSELHAGGLQAQPVHGFFGGQQPHHGHPGSHHPHQHHPHFGGNFGGPDPGASCLHGGRLLGYGGAAGGLGSQPPFAEGYEHMAESQGPESFGPQRPGNLPDFHSSGASSHAVPAPCLPLDQSPNRAASFHGLPSSSGSDSHSLEPRRVTNQGAVDSLEYNYPGEAPSGHFDMFSPSDSEGQLPHYAAGRQVPGGAFPGASAMPRAAGMVGLSKMHAQPPQQQPQQQQQPQQQQQQHGVFFERFSGARKMPVGLEPSVGSRHPLMQPPQQAPPPPQQQPPQQPPQQQPPPPPGLLVRQNSCPPALPRPQQGEAGTPSGGLQDGGPMLPSQHAQFEYPIHRLENRSMHPYSEPVFSMQHPPPQQAPNQRLQHFDAPPYMNVAKRPRFDFPGSAGVDRCASWNGSMHNGALDNHLSPSAYPGLPGEFTPPVPDSFPSGPPLQHPAPDHQSLQQQQQQQQQQQQQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLAQLGHPGDVGQGGLVHGGPVGGLAQPNFEREGGSTGAGRLGTFEQQAPHLAQESAWFSGPHPPPGDLLPRRMGGSGLPADCGPHDPSLAPPPPPGGSGVLFRGPLQEPMRMPGEGHVPALPSPGLQFGGSLGGLGQLQSPGAGVGLPSAASERRPPPPDFATSALGGQPGFPFGAAGRQSTPHSGPGVNSPPSAGGGGGSSGGGGGGGAYPPQPDFQPSQRTSASKLGALSLGSFNKPSSKDNLFGQSCLAALSTACQNMIASLGAPNLNVTFNKKNPPEGKRKLSQNETDGAAVAGNPGSDYFPGGTAPGAPGPGGPSGTSSSGSKASGPPNPPAQGDGTSLSPNYTLESTSGNDGKPVSGGGGRGRGRRKRDSGHVSPGTFFDKYSAAPDSGGAPGVSPGQQQASGAAVGGSSAGETRGAPTPHEKALTSPSWGKGAELLLGDQPDLIGSLDGGAKSDSSSPNVGEFASDEVSTSYANEDEVSSSSDNPQALVKASRSPLVTGSPKLPPRGVGAGEHGPKAPPPALGLGIMSNSTSTPDSYGGGGGPGHPGTPGLEQVRTPTSSSGAPPPDEIHPLEILQAQIQLQRQQFSISEDQPLGLKGGKKGECAVGASGAQNGDSELGSCCSEAVKSAMSTIDLDSLMAEHSAAWYMPADKALVDSADDDKTLAPWEKAKPQNPNSKEAHDLPANKASASQPGSHLQCLSVHCTDDVGDAKARASVPTWRSLHSDISNRFGTFVAALT", "length": 1320 }, "evidence": [ { "id": "F1MG71", "url": "https://omabrowser.org/oma/group/F1MG71/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GG28-1", "protein_name": "MN1 proto-onco, transcriptional regulator", "gene_name": "MN1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MFGLEQFEPQMSSRSGGQGERGFGQPGLSMSAHFKAPAFPGGGPAAAVDPALGALGEPPLLGMNMSLPGDGYGFPGRGPAELHGAGMQPPVHGFFGGQQPHGGHGGAHHPHQHQHQHQHQPHFGGNFGPDPGASCVHGGRLLGYNGALGGQTAFADGYEHMAESQGAEGFGQQRAGNLPDFQQHSAGASGHAVPAPCLPLDQSPNRAASFHGLPAAGSSEPHGLEQRRLPAQDSLEYNYPGDGPAAHFELPVFSPSEPEGQLPHYGGGRQVPAGGGFAGTALPRAPGMAVAKAQPPPPPPPPPQQPQQQQHGVFFERFGGARKMPASLEPGASARHPLMQQQQPQQPPGLLARQNSCPPAIPRQQQTEANAPNPNLQDNGPIMQNQHAQFEYPIHRLENRNMHPYADPVFNMQHPPPQQPPNQRLQHFDAPYVSVAKRPRFDFPGNPGVERCASWAGGMHGPAMESHLSPTAYPGLPGDFTPPAPDAFGGPLPHGGPEHPALAQRQNAALVMKQMASRSQQRLRPPSLQQLGHHGEVGPPGSLPPPGFEREAAAAARGFDAPAPHLAPDGTWFAGPPPPGELLPRRMAGPGLPAEAAPHELGLQPGGAAVLFRPGAGALGLQEPLRMAGEGPAQALPSPGVHPPFAPAVGGLSQLQSPGGGVALPSAPAERRGPADFAAQPGFPFGAAARQPPAHGNAPALSASPGAYPPPPPEFPPPPPPPRPAASKLGALSLGSFSKPAGKDNVFGQSCLAALSTACQNMIASLGAPNLNVTFNKKSPAEAKRKLSQAEPDPPPPAAPDYFPAGPTAGGGAGKAAPLLPAESSLSPGFALEPAAGGEGKAGGGRGRGRRKRDSGHVSPGTFFEKFSAAEGGGAGVSPGQPAPPAAGGPPGAAGAERGGGTPHDKPLTSPSWGKGGELLLGEQPDLMSSLDSGIQSVTKSDGSSPHVDFADEVSTSYGNEDEVSSSSDNAGPKPTRSPLLGGSPKLPRGEHALLNGQKPLALGLLNTSTSTPDSYGLSSTAGAHPGTPGMEQVRTPTSTSAQDEIHPLEILQAQIQLQRQQFSISEDQPLGLKSKKGECAGQNGDSDLGGCCPEGVKNTMSTIDLDSLMAEHNSTWYLPGEKALMEGQEEDKPMAPWEKPKPPNPSKEAHDLPPSKTSATAQTGSHLQCLSVHCTDDVGEAKGRTAVPTWRSLHSDISNRFGTFVAALT", "length": 1210 }, "evidence": [ { "id": "F1MG71", "url": "https://omabrowser.org/oma/group/F1MG71/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MG71", "url": "https://www.uniprot.org/uniprotkb/F1MG71" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1MG71", "url": "https://www.uniprot.org/uniprotkb/F1MG71" } ], "pmid": "" }, { "name": "negative regulation of osteoblast proliferation", "id": "GO:0033689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033689", "evidence": [ { "database": "UniProtKB", "id": "F1MG71", "url": "https://www.uniprot.org/uniprotkb/F1MG71" } ], "pmid": "" }, { "name": "regulation of cell cycle G1/S phase transition", "id": "GO:1902806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902806", "evidence": [ { "database": "UniProtKB", "id": "F1MG71", "url": "https://www.uniprot.org/uniprotkb/F1MG71" } ], "pmid": "" }, { "name": "positive regulation of vitamin D receptor signaling pathway", "id": "GO:0070564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070564", "evidence": [ { "database": "UniProtKB", "id": "F1MG71", "url": "https://www.uniprot.org/uniprotkb/F1MG71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 475, "end_pos": 477, "annotation": "n_glycosylation_sequon" }, { "start_pos": 834, "end_pos": 836, "annotation": "n_glycosylation_sequon" }, { "start_pos": 852, "end_pos": 854, "annotation": "n_glycosylation_sequon" }, { "start_pos": 910, "end_pos": 912, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 394 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 422, "end_pos": 424 }, { "start_pos": 475, "end_pos": 477 }, { "start_pos": 834, "end_pos": 836 }, { "start_pos": 852, "end_pos": 854 }, { "start_pos": 910, "end_pos": 912 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MG89-1", "uniprot_ac": "F1MG89", "uniprot_id": "F1MG89_BOVIN", "mass": { "chemical_mass": 21101.0, "monoisotopic_mass": 21101.0 }, "refseq": { "ac": "XP_015330188", "name": "achaete-scute homolog 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330188" }, "gene_names": [ { "name": "ASCL3", "type": "recommended", "evidence": [ { "id": "F1MG89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG89" } ] }, { "name": "ASCL3", "type": "synonym", "evidence": [ { "id": "XP_015330188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330188" } ] } ], "protein_names": [ { "name": "Achaete-scute family bHLH transcription factor 3", "type": "synonym", "evidence": [ { "id": "F1MG89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG89/entry#names_and_taxonomy" } ] }, { "name": "achaete-scute homolog 3", "type": "synonym", "evidence": [ { "id": "XP_015330188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330188" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MG89", "url": "https://www.uniprot.org/uniprotkb/F1MG89" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ASCL3", "url": "https://www.uniprot.org/uniprotkb/F1MG89", "locus": { "chromosome": "15", "start_pos": 43656849, "end_pos": 43656304, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000032339", "url": "https://www.ensembl.org/id/ENSBTAG00000032339" } ] } } ], "crossref": [ { "id": "F1MG89", "url": "https://alphafold.ebi.ac.uk/entry/F1MG89", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000032339", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000032339", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19745", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19745", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "786757", "url": "https://www.ncbi.nlm.nih.gov/gene/786757", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:786757", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786757", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR23349", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23349", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23349:SF108", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23349:SF108", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00010", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00010", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015330188", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330188", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MG89", 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Achaete-scute family bHLH transcription factor 3 OS=Bos taurus OX=9913 GN=ASCL3 PE=4 SV=3 CANONICAL=F1MG89-1" }, "locus": { "chromosome": "15", "start_pos": 43656846, "end_pos": 43656304, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000045877.4", "url": "https://www.ensembl.org/id/ENSBTAT00000045877.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043229.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043229.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:786757", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786757", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MG89", 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Huntingtin-interacting protein K OS=Bos taurus OX=9913 GN=HYPK PE=4 SV=3 CANONICAL=F1MGE9-1" }, "locus": { "chromosome": "21", "start_pos": 55421793, "end_pos": 55420629, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022876.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022876.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022876.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022876.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100138230", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138230", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2LC79-1", "protein_name": "Huntingtin-interacting protein K isoform X1", "gene_name": "Hypk", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": 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"sequence": "MEGAEEAGAEIAVDSKDLQQQSKAFDKLTDRVEDRQLDSSRVQSAMASIAASREADLNAKRLREKELASVKINPADVEFIVNELEIEKNVAERTLREHKGDAVAATRQLLSRYPL", "length": 115 }, "evidence": [ { "id": "F1MGE9", "url": "https://omabrowser.org/oma/group/F1MGE9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9CR41-1", "protein_name": "Huntingtin-interacting protein K", "gene_name": "Hypk", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEEKEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMTEMEISRAAAERSLREHMGNVVEALIALTN", "length": 121 }, "evidence": [ { "id": "F1MGE9", "url": "https://omabrowser.org/oma/group/F1MGE9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NX55-2", "protein_name": "Huntingtin-interacting protein K", "gene_name": "HYPK", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377157" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MGG9", "url": "https://www.uniprot.org/uniprotkb/F1MGG9#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MGG9", "url": "https://www.uniprot.org/uniprotkb/F1MGG9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR10R3", "url": "https://www.uniprot.org/uniprotkb/F1MGG9", "locus": { "chromosome": "3", "start_pos": 11295134, "end_pos": 11296087, "strand": "+", "evidence": 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"MEFLGTTQTATYCGPKKPCGGSVLPSVASGPTVQECYQPYYLPGYRYLNAWRPSLFYKVANAQTCLDEGATCRSALRPPTILPAVRSALFCRYSPQDWDQSNRLQLCGAEASRLWAGRMTGDSMRLMQDKDQLTRQMQEGTCRNLGQRLSDIGFWKSELNYELERLLNENHSLDAIKRRLECAAEELRCPLQVALECLYQREKRIGIDLVHDNVEKNLIREVDMIKCCQEQMRKLAQRIDIQMRDNRDAQHALERDLEDKNSAEFIDEKCLNLRNTSDCISFFHGVEKIDGTISVPETWAKFSNDNIRHSQNMRANSIRLREEAQNLFDVLADQLWRQFTNTNLAFNARIAEETDVKNKLQTQLAKTLQEIFQTENTIMLLERSIMAKECPLKVAQTRLECRTRRPNVELCRDSPQFKLVNEVFTIDDTLQTLKLRLRETRDTLQLLVMTKCRLEHELAIKANTLCIDKEKCMAMRKTFPSTPCMGICP", "length": 489, "header": "tr|F1MGH5-1|F1MGH5_BOVIN Isoform 1 of Tektin OS=Bos taurus OX=9913 GN=TEKT5 PE=3 SV=3 CANONICAL=F1MGH5-1" }, "locus": { "chromosome": "25", "start_pos": 9414465, "end_pos": 9365200, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022625.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022625.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022625.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022625.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 32, "start_aa": "Thr", "end_pos": 32, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr32", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "Q96M29-1", "protein_name": "Tektin-5", "gene_name": "TEKT5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEFLGTTQTASYCGPKKCCGLTSLPAVQAPVIQECYQPYYLPGYRYLNSWRPSLFYKIANVQTCPDESTSTLRPPTILPTLRSALFSRYSPHDWDQSNQLQVRGAEASRLWASRLTDDSMRLLQDKDQLTHQMQEGTCRNLGQRLSDIGFWKSELSYELDRLLTENQNLETVKRRLECAANEVNCPLQVALECLYHREKRIGIDLVHDNVEKNLIREVDLLKCCQEQMRKLAQRIDIQMRDNRDAQHVLERDLEDKSSAQCIDEKCFNLRNTSDCISFFHGMEKIDGTISVPETWAKFSNDNIKHSQNMRANSIQLREEAEHLFETLSDQMWRQFTDTNLAFNARISEVTDVKNKLQTQLAKTLQEIFQAENTIMLLERSIMAKEGPLKVAQTRLECRTRRPNMELCRDIPQLKLVNEVFTIDDTLQTLKLRLRETQDTLQLLVMTKCRLEHELAIKANTLCIDKEKCMGMRKTFPCTPRLVGHT", "length": 485 }, "evidence": [ { "id": "F1MGH5", "url": "https://omabrowser.org/oma/group/F1MGH5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cilium movement involved in cell motility", "id": "GO:0060294", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060294", "evidence": [ { "database": "UniProtKB", "id": "F1MGH5", "url": "https://www.uniprot.org/uniprotkb/F1MGH5" } ], "pmid": "" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "F1MGH5", "url": "https://www.uniprot.org/uniprotkb/F1MGH5" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "F1MGH5", "url": "https://www.uniprot.org/uniprotkb/F1MGH5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "F1MGH5", "url": "https://www.uniprot.org/uniprotkb/F1MGH5" } ], "pmid": "" }, { "name": "sperm flagellum", "id": "GO:0036126", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "evidence": [ { "database": "UniProtKB", "id": "F1MGH5", "url": "https://www.uniprot.org/uniprotkb/F1MGH5" } ], "pmid": "" }, { "name": "axonemal A tubule inner sheath", "id": "GO:0160111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160111", "evidence": [ { "database": "UniProtKB", "id": "F1MGH5", "url": "https://www.uniprot.org/uniprotkb/F1MGH5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MGH5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 489, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MGH5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MGH5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 32 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 170, "end_pos": 172 }, { "start_pos": 275, "end_pos": 277 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"uniprot_canonical_ac": "F1MGJ5-1", "uniprot_ac": "F1MGJ5", "uniprot_id": "F1MGJ5_BOVIN", "mass": { "chemical_mass": 88719.0, "monoisotopic_mass": 88719.0 }, "refseq": {}, "gene_names": [ { "name": "SEL1L", "type": "recommended", "evidence": [ { "id": "F1MGJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5" } ] } ], "protein_names": [ { "name": "Protein sel-1 homolog 1", "type": "recommended", "evidence": [ { "id": "F1MGJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5/entry#names_and_taxonomy" } ] }, { "name": "Suppressor of lin-12-like protein 1", "type": "synonym", "evidence": [ { "id": "F1MGJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.", "evidence": [ { "database": "UniProtKB", "id": "F1MGJ5", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5#function" }, { "database": "UniProtKB", "id": "ARBA00054921", "url": "https://www.uniprot.org/uniprotkb/ARBA00054921#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MGJ5", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SEL1L", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5", "locus": { "chromosome": "10", "start_pos": 92758415, "end_pos": 92823117, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008083", "url": "https://www.ensembl.org/id/ENSBTAG00000008083" } ] } } ], "crossref": [ { "id": "F1MGJ5", "url": "https://alphafold.ebi.ac.uk/entry/F1MGJ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008083", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008083", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00062", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00062", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006597", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006597", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050767", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050767", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LLGHWMD", "url": "https://omabrowser.org/oma/group/LLGHWMD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11102", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11102", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11102:SF70", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11102:SF70", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00040", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00040", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08238", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08238", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-382556", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5358346", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5358346", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9931269", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931269", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MGJ5", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGJ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRVWVGLTLLLWAVLLGSALASSDEEGNQDESVDSKTSVPSDESVENHSPASRVIAGQIFLDSEESELESPPQEEEGNLRSQEGESIAEEISFLESPNPENKDYEELTKVRKPALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAARRRQMQEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLTQNIQAAKEMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWSERLMTAYSSYKDGDSNAAVIQYLLLAEQGYEVAQSNAAFILDQREATIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIRETNIRDIFTQLDMDQLLGPEWDLYLMTIIALLLGTVIAYRQRQHQDMPVPRPPGPRPAPPQQEGPPEQPPLQ", "length": 794, "header": "tr|F1MGJ5-1|F1MGJ5_BOVIN Isoform 1 of Protein sel-1 homolog 1 OS=Bos taurus OX=9913 GN=SEL1L PE=3 SV=3 CANONICAL=F1MGJ5-1" }, "isoforms": [ { "isoform_ac": "F1MGJ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5/entry", "sequence": { "sequence": "MRVWVGLTLLLWAVLLGSALASSDEEGNQDESVDSKTSVPSDESVENHSPASRVIAGQIFLDSEESELESPPQEEEGNLRSQEGESIAEEISFLESPNPENKDYEELTKVRKPALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAARRRQMQEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLTQNIQAAKEMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWSERLMTAYSSYKDGDSNAAVIQYLLLAEQGYEVAQSNAAFILDQREATIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIRETNIRDIFTQLDMDQLLGPEWDLYLMTIIALLLGTVIAYRQRQHQDMPVPRPPGPRPAPPQQEGPPEQPPLQ", "length": 794, "header": "tr|F1MGJ5-1|F1MGJ5_BOVIN Isoform 1 of Protein sel-1 homolog 1 OS=Bos taurus OX=9913 GN=SEL1L PE=3 SV=3 CANONICAL=F1MGJ5-1" }, "locus": { "chromosome": "10", "start_pos": 92823009, "end_pos": 92762507, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010628.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010628.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010628.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010628.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-382556", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-382556", "resource": "Reactome", "description": "ABC-family protein mediated transport" }, { "id": "R-BTA-5358346", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5358346", "resource": "Reactome", "description": "Hedgehog ligand biogenesis" }, { "id": "R-BTA-9931269", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9931269", "resource": "Reactome", "description": "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1SYF7-1", "protein_name": "Protein sel-1 homolog 1", "gene_name": "SEL1L", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRVGVRLTLLLCVVLLGSASVSSDEEGDQDESLDSKTSLPSDESVKDHSPTGRVVAGQLFLESEESEVESPIQEEEDSLRSQEGESVAEEINFLESPNPENRDYEEPTKVRKPALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAAGMNHTKALERVSYALLFGDYLSQNIQAAKGMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWSERLMTAYNSYKDGDYNAAVVQYLLLAEQGYEVAQSNAAFILDQREATIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIRETNIRDMFTHLDMDQLLGPEWDLYLMTIIALLLGTVIAYRQRQHQDMPVPRPPGPRPAPPQQEGPPEQQAPQ", "length": 794 }, "evidence": [ { "id": "F1MGJ5", "url": "https://omabrowser.org/oma/group/F1MGJ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q05787-1", "protein_name": "ERAD-associated E3 ubiquitin-protein ligase component HRD3", "gene_name": "HRD3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MITLLLYLCVICNAIVLIRADSIADPWPEARHLLNTIAKSRDPMKEAAMEPNADEFVGFYVPMDYSPRNEEKNYQSIWQNEITDSQRHIYELLVQSSEQFNNSEATYTLSQIHLWSQYNFPHNMTLAHKYLEKFNDLTHFTNHSAIFDLAVMYATGGCASGNDQTVIPQDSAKALLYYQRAAQLGNLKAKQVLAYKYYSGFNVPRNFHKSLVLYRDIAEQLRKSYSRDEWDIVFPYWESYNVRISDFESGLLGKGLNSVPSSTVRKRTTRPDIGSPFIAQVNGVQMTLQIEPMGRFAFNGNDGNINGDEDDEDASERRIIRIYYAALNDYKGTYSQSRNCERAKNLLELTYKEFQPHVDNLDPLQVFYYVRCLQLLGHMYFTGEGSSKPNIHMAEEILTTSLEISRRAQGPIGRACIDLGLINQYITNNISQAISYYMKAMKTQANNGIVEFQLSKLATSFPEEKIGDPFNLMETAYLNGFIPAIYEFAVMIESGMNSKSSVENTAYLFKTFVDKNEAIMAPKLRTAFAALINDRSEVALWAYSQLAEQGYETAQVSAAYLMYQLPYEFEDPPRTTDQRKTLAISYYTRAFKQGNIDAGVVAGDIYFQMQNYSKAMALYQGAALKYSIQAIWNLGYMHEHGLGVNRDFHLAKRYYDQVSEHDHRFYLASKLSVLKLHLKSWLTWITREKVNYWKPSSPLNPNEDTQHSKTSWYKQLTKILQRMRHKEDSDKAAEDSHKHRTVVQNGANHRGDDQEEASEILGFQMEDLVTMGCILGIFLLSILMSTLAARRGWNVRFNGAQLNANGNRQQEQQQQQQAQGPPGWDFNVQIFAI", "length": 833 }, "evidence": [ { "id": "F1MGJ5", "url": "https://omabrowser.org/oma/group/F1MGJ5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q5RIK6-1", "protein_name": "Protein sel-1 homolog 1", "gene_name": "sel1l", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNSAKKSCLVLIVALAVTLEVTAGEVPSDDGVGEGGDSQSTAENEGANIVTGRAYVPKDAQTDSSTTDTDMEIKVDEIEKEDLPSQPPPPQERSKEVPVVNGGTASGEPCIFPFLFQGKEYSDCTTEGRGDGRLWCATTYDYNNDKRWGFCETEEQAEQRRMAEEAEEQYQATVRMINGTNRRSQKKELFDKLLQVAEMGHTKAMEKVAYAMLFGDYLPQSIPQAKEMFEKLALEGSPKAQTALGFLYAAGLGVNSSQAKALVYYTFGALGGNLVAHMILGYRYWGGVGVPQSCESALTHYRLVANHVASDVSLTGGSAVQRIRLLDEVENPGSSSGMLEEDLIQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAYEYFNQAANAGNTHAMAFLGKMYSEGSEYVPQNNETALHYFKKAADLGNPVGQSGLGMAYLYGRGVPVNYDLALKYFQKAAEQGWVDGQLQLGTMYYNGIGVKRDYKQALKFFNLASQAGHILAFYNLAQMHATGTGVMRSCHTAVELFKNVCERGRWSERLMAAYRSFKEGDMDSALIQYLLLAEQGYEVAQSNVAFVLDQKGSQIFNENETYPRALLHWTRAAAQGYTVARIKLGDYHFYGYGTDVDYETAVIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGLVYALQYLQDLNLKEVLSQVDLDQLLGPEWDLYLMTVIALLLGTVIAYRQRQHQAVPRAPAAPNRPPAQPEQPAEEPEEQ", "length": 776 }, "evidence": [ { "id": "F1MGJ5", "url": "https://omabrowser.org/oma/group/F1MGJ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q80Z70-1", "protein_name": "Protein sel-1 homolog 1", "gene_name": "Sel1l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQVRVRLLLLLCAVLLGSAAASSDEETNQDESLDSKGALPTDGSVKDHTTGKVVLLARDLLILKDSEVESLLQDEEESSKSQEEVSVTEDISFLDSPNPSSKTYEELKRVRKPVLTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKTDEKWGFCETEEDAAKRRQMQEAEAIYQSGMKILNGSTRKNQKREAYRYLQKAAGMNHTKALERVSYALLFGDYLTQNIQAAKEMFEKLTEEGSPKGQTGLGFLYASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWSERLMTAYNSYKDDDYNAAVVQYLLLAEQGYEVAQSNAAFILDQREATIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIREANIRDLFTQLDMDQLLGPEWDLYLMTIIALLLGTVIAYRQRQHQDIPVPRPPGPRPAPPQQEGPPEQQPPQ", "length": 794 }, "evidence": [ { "id": "F1MGJ5", "url": "https://omabrowser.org/oma/group/F1MGJ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9LM25-1", "protein_name": "ERAD-associated E3 ubiquitin-protein ligase component HRD3A", "gene_name": "HRD3A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MRILSYGIVILSLLVFSFIEFGVHARPVVLVLSNDDLNSGGDDNGVGESSDFDEFGESEPKSEEELDPGSWRSIFEPDDSTVQAASPQYYSGLKKILSAASEGNFRLMEEAVDEIEAASSAGDPHAQSIMGFVYGIGMMREKSKSKSFLHHNFAAAGGNMQSKMALAFTYLRQDMHDKAVQLYAELAETAVNSFLISKDSPVVEPTRIHSGTEENKGALRKSRGEEDEDFQILEYQAQKGNANAMYKIGLFYYFGLRGLRRDHTKALHWFLKAVDKGEPRSMELLGEIYARGAGVERNYTKALEWLTLAAKEGLYSAFNGIGYLYVKGYGVDKKNYTKAREYFEKAVDNEDPSGHYNLGVLYLKGIGVNRDVRQATKYFFVAANAGQPKAFYQLAKMFHTGVGLKKNLEMATSFYKLVAERGPWSSLSRWALEAYLKGDVGKALILYSRMAEMGYEVAQSNAAWILDKYGERSMCMGVSGFCTDKERHERAHSLWWRASEQGNEHAALLIGDAYYYGRGTERDFVRAAEAYMHAKSQSNAQAMFNLGYMHEHGQGLPFDLHLAKRYYDESLQSDAAARLPVTLALASLWLRRNYADTVLVRVVDSLPEVYPKVETWIENVVFEEGNATILTLFVCLITILYLRERQRRQVVVVADPVAADVAQPLDADVAQHLAAFPR", "length": 678 }, "evidence": [ { "id": "F1MGJ5", "url": "https://omabrowser.org/oma/group/F1MGJ5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9UBV2-1", "protein_name": "Protein sel-1 homolog 1", "gene_name": "SEL1L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRVRIGLTLLLCAVLLSLASASSDEEGSQDESLDSKTTLTSDESVKDHTTAGRVVAGQIFLDSEESELESSIQEEEDSLKSQEGESVTEDISFLESPNPENKDYEEPKKVRKPALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWSERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEVAQSNAAFILDQREASIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIRETNIRDMFTQLDMDQLLGPEWDLYLMTIIALLLGTVIAYRQRQHQDMPAPRPPGPRPAPPQQEGPPEQQPPQ", "length": 794 }, "evidence": [ { "id": "F1MGJ5", "url": "https://omabrowser.org/oma/group/F1MGJ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9V415-1", "protein_name": "HMG-coA reductase degradation 3, isoform B", "gene_name": "Hrd3", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MKANSWMCLLALLLAWQLRAEELQGPNIDGTGSSLGSATGTGTGTGLGTGTATPTLPNEPSTQAEAEEVTTAESESRVPSESNERKADKPKESTKFASRTKVMPASLFERLWNESLIRRQKLKAEIERIEAKRKSTEVLELTPDQIEAQTVYDNAMDMLAKPSTDKRVAMILLKKAAAFNHLKARAELAWAALLGQWMDFDFNHAVDEFESLANEGVPEAHMGLGFLYSVGVGGKNVSQPLALIHYSLAALGDNTPAQMAMGYRYLYGINVPISCEKALIHYKRVAKKVASKITFANGPVVHRVRLLDDLENPGSSETEIVDYYKLLADKGDIQSQVGLGQVYYQGGKVTEQDHQKALEYFKMAADAGSAVGIAFLGKLYLEGSDQIRADNDAAFGYFSKAAEMGDPVGQSGLGLMYLKGLGVPKDSIKALSYFTQAADQGWVDGQLQLGNMYFTGNGVKTDYKLAFKYFNLATQSGHVLAYYNLGVMNAYGMGMLRSCPAAVEFFKTVSERGRWSSRLMMAYSDYKNNRIDEAYMQYSLMAEMGYEVAQSNAAFLLDRKEVHVFNDRHEDLIRAFYYWKRAAGQGYSAAQVKLGDYYYYGWGTSTDFETAAALYRKASEQQYNAQAMFNLGYMHEQGLGMKKDWHLAKRLYDLAAETNSDAKVPVAIALFKLQMLATIESIKESPYRFIFYMDENIAANWDLYMITVLTLLLGIIMYMRRPFQQPDQPAQQPAADDIAAAPVNLAPVGAEAAPVAAVVEGVGVTPPAAAVSSHDAVAASSSTETSSTTATSLVDAASQGGSGTTSAAPDGANTLDPTG", "length": 819 }, "evidence": [ { "id": "F1MGJ5", "url": "https://omabrowser.org/oma/group/F1MGJ5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Z2G6-1", "protein_name": "Protein sel-1 homolog 1", "gene_name": "Sel1l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQVRVRLSLLLLCAVLLGSAAATSDDKTNQDDSLDSKSSLPTDESVKDHTTTGKVVAGQIFVDSEEAEVESLLQDEEDSSKTQEEEISFLESPNPSSKTYEELKRVRKPVLTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKTDEKWGFCETEEDAAKRRQMQEAEMIYQAGMKILNGSNRKSQKREAYRYLQKAAGMNHTKALERVSYALLFGDYLTQNIQAAKEMFEKLTEEGSPKGQTGLGFLYASGLGVNSSQAKALVYYTFGALGGNLIAHMILGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWSERLMTAYNSYKDEDYNAAVVQYLLLAEQGYEVAQSNAAFILDQREATIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIREANIRDLFTQLDMDQLLGPEWDLYLMTIIALLLGTVIAYRQRQHQDIPVPRPPGPRPAPPQQEGPPEQQPPQ", "length": 790 }, "evidence": [ { "id": "F1MGJ5", "url": "https://omabrowser.org/oma/group/F1MGJ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "triglyceride metabolic process", "id": "GO:0006641", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006641", "evidence": [ { "database": "UniProtKB", "id": "F1MGJ5", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "F1MGJ5", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5" } ], "pmid": "" }, { "name": "protein secretion", "id": "GO:0009306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009306", "evidence": [ { "database": "UniProtKB", "id": "F1MGJ5", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5" } ], "pmid": "" }, { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "F1MGJ5", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5" } ], "pmid": "" }, { "name": "retrograde protein transport, ER to cytosol", "id": "GO:0030970", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030970", "evidence": [ { "database": "UniProtKB", "id": "F1MGJ5", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1MGJ5", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5" } ], "pmid": "" }, { "name": "Derlin-1 retrotranslocation complex", "id": "GO:0036513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036513", "evidence": [ { "database": "UniProtKB", "id": "F1MGJ5", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5" } ], "pmid": "" }, { "name": "Hrd1p ubiquitin ligase ERAD-L complex", "id": "GO:0000839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000839", "evidence": [ { "database": "UniProtKB", "id": "F1MGJ5", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 217, "end_pos": 219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 431, "end_pos": 433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 47, "end_pos": 49, "annotation": "n_glycosylation_sequon" }, { "start_pos": 608, "end_pos": 610, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MGJ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 794, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MGJ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MGJ5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MGJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGJ5" }, { "id": "PS51092", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51092" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-II", "eco_id": "ECO_0000259", "start_pos": 122, "end_pos": 170, "start_aa": "Ala", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 195, "end_pos": 197 }, { "start_pos": 217, "end_pos": 219 }, { "start_pos": 272, "end_pos": 274 }, { "start_pos": 431, "end_pos": 433 }, { "start_pos": 47, "end_pos": 49 }, { "start_pos": 608, "end_pos": 610 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGK8-1", "uniprot_ac": "F1MGK8", "uniprot_id": "F1MGK8_BOVIN", "mass": { "chemical_mass": 105523.0, "monoisotopic_mass": 105523.0 }, "refseq": {}, "gene_names": [ { "name": "OSMR", "type": "recommended", "evidence": [ { "id": "F1MGK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK8" } ] } ], "protein_names": [ { "name": "Oncostatin-M-specific receptor subunit beta", "type": "recommended", "evidence": [ { "id": "F1MGK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK8/entry#names_and_taxonomy" } ] }, { "name": "Interleukin-31 receptor subunit beta", "type": "synonym", "evidence": [ { "id": "F1MGK8", "database": "UniProtKB", "url": 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"categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR003529", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003529", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040817", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040817", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048497", "url": 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"MARPDPSAPPSLLLLLLAQLAGRATAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLSGPPGAPASGSDCVAGGPSVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSPDERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHSHIHYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAALTCACPGPDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCRPRRGHKSGGATATGDYAEASAALTGRTGPPGPAAATYHKQVSLSHV", "length": 586 }, "evidence": [ { "id": "F1MGM1", "url": "https://omabrowser.org/oma/group/F1MGM1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q13467-1", "protein_name": "Frizzled-5", "gene_name": "FZD5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"url": "https://www.uniprot.org/uniprotkb/F1MGM1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1MGM1", "url": "https://www.uniprot.org/uniprotkb/F1MGM1" } ], "pmid": "" }, { "name": "positive regulation of tumor necrosis factor production", "id": "GO:0032760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032760", "evidence": [ { "database": "UniProtKB", "id": "F1MGM1", "url": "https://www.uniprot.org/uniprotkb/F1MGM1" } ], "pmid": "" }, { "name": "positive regulation of T cell cytokine production", "id": "GO:0002726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002726", "evidence": [ { "database": "UniProtKB", "id": "F1MGM1", "url": "https://www.uniprot.org/uniprotkb/F1MGM1" } ], "pmid": "" }, { "name": "positive regulation of type II interferon 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"MRTPVVMTLGMVLAPCGLLLTLTSTLTPGWRLVKGFLDQPLDLVLYQGLWDMCREQSSRERQCGQPDDLGYFAAEPVRVARGLMVTSLAVTGLGLLLATLGVRCWRDEPHFVLAGLSGVVLFTAGLLSLIPVSWYNHFLADRTVLPAQPSPVTVQVGYSLVLGYLGSCLLLLGGFSLALSFAPWCAERCDSCRKAPSSSARRSSISTVYIDGPEPALTPAIKYYSDGQHRPRPDQLGATSQRKAGFPMPRPPPKAYSNPVDVLEGENATNSEPGSSSRSTRPCGSTLPCDSDV", "length": 293, "header": "tr|F1MGT6-1|F1MGT6_BOVIN Isoform 1 of Claudin 23 OS=Bos taurus OX=9913 GN=CLDN23 PE=3 SV=2 CANONICAL=F1MGT6-1" }, "isoforms": [ { "isoform_ac": "F1MGT6-1", "url": "https://www.uniprot.org/uniprotkb/F1MGT6/entry", "sequence": { "sequence": "MRTPVVMTLGMVLAPCGLLLTLTSTLTPGWRLVKGFLDQPLDLVLYQGLWDMCREQSSRERQCGQPDDLGYFAAEPVRVARGLMVTSLAVTGLGLLLATLGVRCWRDEPHFVLAGLSGVVLFTAGLLSLIPVSWYNHFLADRTVLPAQPSPVTVQVGYSLVLGYLGSCLLLLGGFSLALSFAPWCAERCDSCRKAPSSSARRSSISTVYIDGPEPALTPAIKYYSDGQHRPRPDQLGATSQRKAGFPMPRPPPKAYSNPVDVLEGENATNSEPGSSSRSTRPCGSTLPCDSDV", "length": 293, "header": "tr|F1MGT6-1|F1MGT6_BOVIN Isoform 1 of Claudin 23 OS=Bos taurus OX=9913 GN=CLDN23 PE=3 SV=2 CANONICAL=F1MGT6-1" }, "locus": { "chromosome": "27", "start_pos": 24741316, "end_pos": 24740438, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092876.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092876.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081201.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081201.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:514634", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514634", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PZV7-1", "protein_name": "Claudin 23", "gene_name": "CLDN23", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRTPAVMIVGLVLCPCGLLLTLTGTLAPNWRQVSLIPEQPSDLILEQGIWDLCRERQSSHDRLCGQEDELSYFKEVPVQVARGMMPSSLVLTVLGLVVAALGVRCWQKEPQHALAGASGLVLLLSGLLSLVPASWYTHELEVLPAPSGATLAVGYSLVLSYLGSCLEILGGVALTLSFHHCCKERRASKTTPSPVLEPGPRSVTGAYSNPWDVLEDERDGRHGRSTLPCDSDL", "length": 233 }, "evidence": [ { "id": "F1MGT6", "url": "https://omabrowser.org/oma/group/F1MGT6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A288CFV8-1", "protein_name": "Claudin 23", "gene_name": "CLDN23", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRTPVVMTLGMVLAPCGLLLTLTSTLTPGWRLVKGFLDQPVDVVLYQGLWDMCREQSSRERQCGQPDELGYFAAEPVKVARGLMVTSLAVTALGLLLATLGVRCWQDEPHFALAGLSGVVLFAAGLLSLIPVSWYNHFLADRAVLPAQSSPVTVQVGYSLVLGYLGSCLLLLGGFSLALSFAPWCAERCRSCRKASPSSARRSSISTVHVDWLTPAIKYYSDGQHRPGPAQLGPTSRRKAGFPMPRPPPKAYSNQVDVLDGEKSPDSHLDGSSRSTRPCGSALPCDSDL", "length": 289 }, "evidence": [ { "id": "F1MGT6", "url": "https://omabrowser.org/oma/group/F1MGT6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q96B33-1", "protein_name": "Claudin-23", "gene_name": "CLDN23", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRTPVVMTLGMVLAPCGLLLNLTGTLAPGWRLVKGFLNQPVDVELYQGLWDMCREQSSRERECGQTDQWGYFEAQPVLVARALMVTSLAATVLGLLLASLGVRCWQDEPNFVLAGLSGVVLFVAGLLGLIPVSWYNHFLGDRDVLPAPASPVTVQVSYSLVLGYLGSCLLLLGGFSLALSFAPWCDERCRRRRKGPSAGPRRSSVSTIQVEWPEPDLAPAIKYYSDGQHRPPPAQHRKPKPKPKVGFPMPRPRPKAYTNSVDVLDGEGWESQDAPSCSTHPCDSSLPCDSDL", "length": 292 }, "evidence": [ { "id": "F1MGT6", "url": "https://omabrowser.org/oma/group/F1MGT6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D7D7-1", "protein_name": "Claudin-23", "gene_name": "Cldn23", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRTPVVMTLGMVLTPCGLLLNLVSTLAPGWRLVKGFLDQPVDVVLYQGLWDICREQSSRERECGQPDEWNYFQTQPVQVARGLMITSLATTALGLLLASLGVRCWQDEPHYGLAGLSGVVFFVAGLFSLIPVSWYNHFLSDPDVLAAPSSPVTVQVSYSLVLGYLGSCLLLLGGFSLALSFAPWCEERCRRCRKAPPAGPRRSSISTVYVDWPEPALTPAIKYYSDGQHRPPPTAEHRDTSKLKVGFPMPRPPPKSYTNPMDVLEGEEKKTATSQGGSSSRSTRPCQNSLPCDSDL", "length": 296 }, "evidence": [ { "id": "F1MGT6", "url": "https://omabrowser.org/oma/group/F1MGT6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MGT6", "url": "https://www.uniprot.org/uniprotkb/F1MGT6" } ], "pmid": "" }, { "name": "bicellular tight junction", "id": "GO:0005923", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "evidence": [ { "database": "UniProtKB", "id": "F1MGT6", "url": "https://www.uniprot.org/uniprotkb/F1MGT6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "F1MGT6", "url": "https://www.uniprot.org/uniprotkb/F1MGT6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 267, "end_pos": 269, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 267, "end_pos": 269 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGU5-1", "uniprot_ac": "F1MGU5", "uniprot_id": "F1MGU5_BOVIN", "mass": { "chemical_mass": 34665.0, "monoisotopic_mass": 34665.0 }, "refseq": { "ac": "NP_001377064", "name": "olfactory receptor 10W1", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377064" }, "gene_names": [ { "name": "OR10W4", "type": "recommended", "evidence": [ { "id": "F1MGU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGU5" } ] }, { "name": "OR10W4", "type": "synonym", "evidence": [ { "id": "NP_001377064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377064" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1MGU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGU5/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 10W1", "type": "synonym", "evidence": [ { "id": "NP_001377064", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377064" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377064" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MGU5", "url": "https://www.uniprot.org/uniprotkb/F1MGU5#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MGU5", "url": "https://www.uniprot.org/uniprotkb/F1MGU5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR10W4", "url": "https://www.uniprot.org/uniprotkb/F1MGU5", "locus": { "chromosome": "15", "start_pos": 81444654, "end_pos": 81445598, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000040197", "url": "https://www.ensembl.org/id/ENSBTAG00000040197" } ] } } ], "crossref": [ { "id": "F1MGU5", "url": "https://alphafold.ebi.ac.uk/entry/F1MGU5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000040197", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000040197", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15225", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15225", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "531571", "url": "https://www.ncbi.nlm.nih.gov/gene/531571", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:531571", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531571", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GIEICYT", "url": "https://omabrowser.org/oma/group/GIEICYT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGU5", "url": "https://www.orthodb.org/?gene=F1MGU5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR26453", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR26453", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001377064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377064", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MGU5", "url": "https://www.uniprot.org/uniprotkb/F1MGU5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGU5-1", "url": "https://www.uniprot.org/uniprotkb/F1MGU5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSWGNHSLWMEFVFLAYPSQSEPRILSFLGVSLVYTWVITGNVLIMVAIQTEARLHTPMYYFLGSLSGVEIGYTAVVVPHLLANILRSEKTITLLGCATQMGFFIGLGSADCFLLASMAYDRHAAICHPLQYPLIMPRTLCARLVVASVVLGLCLSFQLVAFVFSLPFCPARGIQHFYCDVPPVMCLVCAQSHRHEQSVLVAATLAIAVPFLLIAASYASIVAAVFRAHSASGRRRAFSTCSSHLAVVLLQYCCCAFMYLRPSSSYHPEQDQFVSLVYTLGTPLLNPFVYTLRNSEMKEAIARVLARSCLPRES", "length": 314, "header": "tr|F1MGU5-1|F1MGU5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR10W4 PE=3 SV=3 CANONICAL=F1MGU5-1" }, "isoforms": [ { "isoform_ac": "F1MGU5-1", "url": "https://www.uniprot.org/uniprotkb/F1MGU5/entry", "sequence": { "sequence": "MSWGNHSLWMEFVFLAYPSQSEPRILSFLGVSLVYTWVITGNVLIMVAIQTEARLHTPMYYFLGSLSGVEIGYTAVVVPHLLANILRSEKTITLLGCATQMGFFIGLGSADCFLLASMAYDRHAAICHPLQYPLIMPRTLCARLVVASVVLGLCLSFQLVAFVFSLPFCPARGIQHFYCDVPPVMCLVCAQSHRHEQSVLVAATLAIAVPFLLIAASYASIVAAVFRAHSASGRRRAFSTCSSHLAVVLLQYCCCAFMYLRPSSSYHPEQDQFVSLVYTLGTPLLNPFVYTLRNSEMKEAIARVLARSCLPRES", "length": 314, "header": "tr|F1MGU5-1|F1MGU5_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR10W4 PE=3 SV=3 CANONICAL=F1MGU5-1" }, "locus": { "chromosome": "15", "start_pos": 81445598, "end_pos": 81444657, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056063.3", "url": "https://www.ensembl.org/id/ENSBTAT00000056063.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048050.3", "url": "https://www.ensembl.org/id/ENSBTAP00000048050.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:531571", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:531571", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZE76-1", "protein_name": "Olfactory receptor", "gene_name": "Or10w1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPVDSMTWENHTLFMEFVFLAYPKHPVLRMLCFFGVSLAYGLIISGNILIVVSIKTEIRLHTPMYYFLGSLSGIELCYTAVVVPHILANTFQSEKTITLLSCATQMVFLIGLGSADCFLLAIMAYDRYFAICHPLQYPLIMTVTLCVRLVVASVVIGLFLSLQLVVFIFCLPFCQDRGIEHFFCDAPPMMRLVCATSHIHELSVLVAATIAIAVPFFFIATTYALIVAAVLKLHSAAGRHRAFNTCSSHLTVVLLQYGCCAFMYLRPVSSYHPKQDKFISLVYILGTPFLNPLIYTLRNNEMKGAIAKVLTRKYLSWKIIG", "length": 321 }, "evidence": [ { "id": "F1MGU5", "url": "https://omabrowser.org/oma/group/F1MGU5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TQQ5-1", "protein_name": "Olfactory receptor", "gene_name": "Or10w1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTWKNHSLFMEFVFLAYPKRPELRMLCFFGVSLAYGLIISGNILIVVSIQTETRLHTPMYYFLGSLSGIELCYTAVVVPHILANNFQSEKTISLLSCATQMVFLIGLGSADCFLLAIMAYDRYVAICHPLQYPLIMTITLCVRLVVASVVIGLFLSLQLVVFIFCLPFCQDRGIEHFFCDAPPLMRLVCATSHIHELSVLMAATLAIAVPFFFIATTYALIVAAVLKLHSAAGRHRAFNTCSSHLTVVLLQYGCCAFMYLRPVSSYHPKQDQFVSLVYTLGTPFLNPLIYTLRNSEMKGAIGKVLTRKYLSWKMIG", "length": 316 }, "evidence": [ { "id": "F1MGU5", "url": "https://omabrowser.org/oma/group/F1MGU5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NGF6-1", "protein_name": "Olfactory receptor 10W1", "gene_name": "OR10W1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEFVFLAYPSCPELHILSFLGVSLVYGLIITGNILIVVSIHTETCLCTSMYYFLGSLSGIEICYTAVVVPHILANTLQSEKTITLLGCATQMAFFIALGSADCFLLAAMAYDRYVAICHPLQYPLLMTLTLCVHLVVASVISGLFLSLQLVAFIFSLPFCQAQGIEHFFCDVPPVMHVVCAQSHIHEQSVLVAAILAIAVPFFLITTSYTFIVAALLKIHSAAGRHRAFSTCSSHLTVVLLQYGCCAFMYLCPSSSYNPKQDRFISLVYTLGTPLLNPLIYALRNSEMKGAVGRVLTRNCLSQNS", "length": 305 }, "evidence": [ { "id": "F1MGU5", "url": "https://omabrowser.org/oma/group/F1MGU5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MGU5", "url": "https://www.uniprot.org/uniprotkb/F1MGU5" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1MGU5", "url": "https://www.uniprot.org/uniprotkb/F1MGU5" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "F1MGU5", "url": "https://www.uniprot.org/uniprotkb/F1MGU5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MGU5", "url": "https://www.uniprot.org/uniprotkb/F1MGU5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MGU5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 314, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MGU5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MGU5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MGU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGU5" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGV3-1", "uniprot_ac": "F1MGV3", "uniprot_id": "F1MGV3_BOVIN", "mass": { "chemical_mass": 79587.0, "monoisotopic_mass": 79587.0 }, "refseq": { "ac": "XP_010805866", "name": "RING finger protein 145 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805866" }, "gene_names": [ { "name": "RNF145", "type": "recommended", "evidence": [ { "id": "F1MGV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGV3" } ] }, { "name": "RNF145", "type": "synonym", "evidence": [ { "id": "XP_010805866", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805866" } ] } ], "protein_names": [ { "name": "RING finger protein 145", "type": "recommended", "evidence": [ { "id": "F1MGV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGV3/entry#names_and_taxonomy" } ] }, { "name": "RING finger protein 145 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010805866", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805866" } ] } ], "function": [ { "annotation": "E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function. In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately down-regulating cholesterol biosynthesis.", "evidence": [ { "database": "UniProtKB", "id": "F1MGV3", "url": "https://www.uniprot.org/uniprotkb/F1MGV3#function" }, { "database": "UniProtKB", "id": "ARBA00058477", "url": "https://www.uniprot.org/uniprotkb/ARBA00058477#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MGV3", "url": "https://www.uniprot.org/uniprotkb/F1MGV3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RNF145", "url": "https://www.uniprot.org/uniprotkb/F1MGV3", "locus": { "chromosome": "7", "start_pos": 70734078, "end_pos": 70796784, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025099", "url": "https://www.ensembl.org/id/ENSBTAG00000025099" } ] } } ], "crossref": [ { "id": "F1MGV3", "url": "https://alphafold.ebi.ac.uk/entry/F1MGV3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025099", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025099", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16684", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16684", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534282", "url": "https://www.ncbi.nlm.nih.gov/gene/534282", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025754", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025754", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047823", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047823", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050731", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050731", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MHSAPLH", "url": "https://omabrowser.org/oma/group/MHSAPLH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGV3", "url": "https://www.orthodb.org/?gene=F1MGV3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22763", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22763", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22763:SF167", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22763:SF167", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13639", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13639", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13705", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13705", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_010805866", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805866", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MGV3", "url": "https://www.uniprot.org/uniprotkb/F1MGV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGV3-1", "url": "https://www.uniprot.org/uniprotkb/F1MGV3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAKEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLNNNPLFQYKYLALNMHYVGYILSVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVRSELESAYEGPMYLEPLSMNRFTTALIGQLVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLPIATKEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHLKNSSQLPGLGADPVPQPPAGAEQHALRGGTEAPGQELPQGPRAQEGSRDKDVPQPPAGAEQHALQGGTEAPGQELPQGPGAQEGSRDKDEGIARRSDSQEGTCDPKENPPGAEDEALPVEVGLEEKQQE", "length": 707, "header": "tr|F1MGV3-1|F1MGV3_BOVIN Isoform 1 of RING finger protein 145 OS=Bos taurus OX=9913 GN=RNF145 PE=4 SV=1 CANONICAL=F1MGV3-1" }, "isoforms": [ { "isoform_ac": "F1MGV3-1", "url": "https://www.uniprot.org/uniprotkb/F1MGV3/entry", "sequence": { "sequence": "MAAKEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLNNNPLFQYKYLALNMHYVGYILSVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVRSELESAYEGPMYLEPLSMNRFTTALIGQLVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLPIATKEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHLKNSSQLPGLGADPVPQPPAGAEQHALRGGTEAPGQELPQGPRAQEGSRDKDVPQPPAGAEQHALQGGTEAPGQELPQGPGAQEGSRDKDEGIARRSDSQEGTCDPKENPPGAEDEALPVEVGLEEKQQE", "length": 707, "header": "tr|F1MGV3-1|F1MGV3_BOVIN Isoform 1 of RING finger protein 145 OS=Bos taurus OX=9913 GN=RNF145 PE=4 SV=1 CANONICAL=F1MGV3-1" }, "locus": { "chromosome": "7", "start_pos": 70790462, "end_pos": 70735315, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056189.3", "url": "https://www.ensembl.org/id/ENSBTAT00000056189.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050056.2", "url": "https://www.ensembl.org/id/ENSBTAP00000050056.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287BES9-1", "protein_name": "RING finger protein 145", "gene_name": "RNF145", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAKEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLSNNPLFQYKYLALNMHYVGYILSVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVRSELESAYEGPMYLEPLSMNRFTTALIGQLVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLPIATKEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHLKNSSQLPGLGSEPVPQPPAGAEQNVPEEGTEPPSQERSEDTRVQEDSKDNEECVARRLDGQEGACDPRENPLSAKDEAHPVEGSLEEKEQE", "length": 669 }, "evidence": [ { "id": "F1MGV3", "url": "https://omabrowser.org/oma/group/F1MGV3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YQB0-1", "protein_name": "RING finger protein 145", "gene_name": "RNF145", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPRRHKGWSAASSQKGKRMAAKEKLEAILNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLHNNPLFQYKYLALNMHYVGYILSVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVRSELESGYEGPMYVEPLSMNRFMTALVGQLVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVVAYGVSETVFGEWTVMGSVIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLPTATKEQLEQHNDICAICYQDMKTAVITPCSHFFHAGCLKKWLYVQETCPLCHCQLKSPSQLQGLGPEPVPQPNPGAEQNVRPGDAAEPPGAEQDSGPNTGDNPSQSDGQDSLEASAETEGFQDVDKGTSPYEASQGAACAAELMAAPEGCPTRDPRVSIQL", "length": 702 }, "evidence": [ { "id": "F1MGV3", "url": "https://omabrowser.org/oma/group/F1MGV3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LYG4-1", "protein_name": "RING finger protein 145", "gene_name": "Rnf145", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAKEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLSNNPLFQYKYLALNMHYVGYILSVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVRSELESAYEGPMYLEPLSMNRFTTALIGQLVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLPIATKEQLERHNDICAICYQEKQDMKSAVITPCSHFFHAGCLKKWLYVQDTCPLCHCHLKNSSQLPGLGTEPAPQPPVAGAEQNIVLQEGPEPPDHETPPGPGAQEGSGDNSEYINRSSASREGDADPGDGPQIAEGEACPVASA", "length": 667 }, "evidence": [ { "id": "F1MGV3", "url": "https://omabrowser.org/oma/group/F1MGV3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5SWK7-1", "protein_name": "RING finger protein 145", "gene_name": "Rnf145", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAKEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLNNNPLFQYKYLALNMHYVGYILSVVLLTLPRQHLVQLYLYFVTALLLYAGHQISRDYVRSELESAYEGPMYLEPLSMNRFTTALIGQLVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFVVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLPVATQEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQDTCPLCHCHLKNSSQLPGLGTEAAPQPPAGAEQNIVLQEGPEPPDHESPPGTGTQEGSGDSSEHINRGSASQEGAADAGEGPQIPEGEVCPVESA", "length": 663 }, "evidence": [ { "id": "F1MGV3", "url": "https://omabrowser.org/oma/group/F1MGV3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96MT1-1", "protein_name": "RING finger protein 145", "gene_name": "RNF145", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAKEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLSNNPLFQYKYLALNMHYVGYILSVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVRSELEFAYEGPMYLEPLSMNRFTTALIGQLVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLPIATKEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHLKNSSQLPGLGTEPVLQPHAGAEQNVMFQEGTEPPGQEHTPGTRIQEGSRDNNEYIARRPDNQEGAFDPKEYPHSAKDEAHPVESA", "length": 663 }, "evidence": [ { "id": "F1MGV3", "url": "https://omabrowser.org/oma/group/F1MGV3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MGV3", "url": "https://www.uniprot.org/uniprotkb/F1MGV3" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1MGV3", "url": "https://www.uniprot.org/uniprotkb/F1MGV3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MGV3", "url": "https://www.uniprot.org/uniprotkb/F1MGV3" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "F1MGV3", "url": "https://www.uniprot.org/uniprotkb/F1MGV3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "F1MGV3", "url": "https://www.uniprot.org/uniprotkb/F1MGV3" } ], "pmid": "" }, { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "F1MGV3", "url": "https://www.uniprot.org/uniprotkb/F1MGV3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 455, "end_pos": 457, "annotation": "n_glycosylation_sequon" }, { "start_pos": 580, "end_pos": 582, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MGV3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 707, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MGV3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MGV3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 455, "end_pos": 457 }, { "start_pos": 580, "end_pos": 582 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGV4-1", "uniprot_ac": "F1MGV4", "uniprot_id": "F1MGV4_BOVIN", "mass": { "chemical_mass": 61684.0, "monoisotopic_mass": 61684.0 }, "refseq": { "ac": "XP_003588080", "name": "organic anion transporter 7-like", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003588080" }, "gene_names": [ { "name": "LOC517475", "type": "recommended", "evidence": [ { "id": "F1MGV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGV4" } ] }, { "name": "LOC517475", "type": "synonym", "evidence": [ { "id": "XP_003588080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003588080" } ] } ], "protein_names": [ { "name": "Major facilitator superfamily (MFS) profile domain-containing protein", "type": "recommended", "evidence": [ { "id": "F1MGV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGV4/entry#names_and_taxonomy" } ] }, { "name": "organic anion transporter 7-like", "type": "synonym", "evidence": [ { "id": "XP_003588080", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003588080" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MGV4", "url": "https://www.uniprot.org/uniprotkb/F1MGV4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC517475", "url": "https://www.uniprot.org/uniprotkb/F1MGV4", "locus": {} } ], "crossref": [ { "id": "F1MGV4", "url": "https://alphafold.ebi.ac.uk/entry/F1MGV4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000003236", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000003236", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17374", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17374", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517475", "url": "https://www.ncbi.nlm.nih.gov/gene/517475", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020846", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020846", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517475", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517475", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CKMIFLL", "url": "https://omabrowser.org/oma/group/CKMIFLL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGV4", "url": "https://www.orthodb.org/?gene=F1MGV4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24064", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24064", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07690", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07690", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_003588080", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003588080", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MGV4", "url": "https://www.uniprot.org/uniprotkb/F1MGV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGV4-1", "url": "https://www.uniprot.org/uniprotkb/F1MGV4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFQDLLDQVGGLGRFQILQMVFFCISSLIVYPHILLENFTAAIPDHRCWVHILDNDTDSANDTGTLSQDAFLRISIPLDSNLRPEKCRRFSHPQWQFLYLNGTFPNMTDLDTEPCVDGWMYDRSSFSSTIVTEWDLVCKSESLISVAKFLVMSGILVGGIVYGYLSDRFGRKFIIRLCFLQLAIVDTFTVIAPNFLIYCSLRFLAGMSATCLLTNNVLLTLEWTEPRFQAMATTLLMAATSLGQTILGGLAFAIRDWHTLQLVMSAPLFVLFLASRWLIESARWLITIDKPKKGLKELQKAAHRNGRKNAGDILTMEVLRSAMQEELEAAETKPSVLDLFRTPNLRKRICLLSFVRFANVLTHFGLTLHLQHLGSNIFMFQILFGIVTIPANYAALLALNHLGRRITQMLFIFLLAVSTLTITCVSEEMQAVRMALAALATGVSFATFASNFCHGSELIPTVLRVTSVGIMGIAANTGAALAPLLMILMVYSPHLPWIIYGVLPILAGLVVPLLPETRNKPLPDSIQDVENEEKSSRKTKQEDTFMKVTQC", "length": 552, "header": "tr|F1MGV4-1|F1MGV4_BOVIN Isoform 1 of Major facilitator superfamily (MFS) profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC517475 PE=4 SV=3 CANONICAL=F1MGV4-1" }, "isoforms": [ { "isoform_ac": "F1MGV4-1", "url": "https://www.uniprot.org/uniprotkb/F1MGV4/entry", "sequence": { "sequence": "MAFQDLLDQVGGLGRFQILQMVFFCISSLIVYPHILLENFTAAIPDHRCWVHILDNDTDSANDTGTLSQDAFLRISIPLDSNLRPEKCRRFSHPQWQFLYLNGTFPNMTDLDTEPCVDGWMYDRSSFSSTIVTEWDLVCKSESLISVAKFLVMSGILVGGIVYGYLSDRFGRKFIIRLCFLQLAIVDTFTVIAPNFLIYCSLRFLAGMSATCLLTNNVLLTLEWTEPRFQAMATTLLMAATSLGQTILGGLAFAIRDWHTLQLVMSAPLFVLFLASRWLIESARWLITIDKPKKGLKELQKAAHRNGRKNAGDILTMEVLRSAMQEELEAAETKPSVLDLFRTPNLRKRICLLSFVRFANVLTHFGLTLHLQHLGSNIFMFQILFGIVTIPANYAALLALNHLGRRITQMLFIFLLAVSTLTITCVSEEMQAVRMALAALATGVSFATFASNFCHGSELIPTVLRVTSVGIMGIAANTGAALAPLLMILMVYSPHLPWIIYGVLPILAGLVVPLLPETRNKPLPDSIQDVENEEKSSRKTKQEDTFMKVTQC", "length": 552, "header": "tr|F1MGV4-1|F1MGV4_BOVIN Isoform 1 of Major facilitator superfamily (MFS) profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC517475 PE=4 SV=3 CANONICAL=F1MGV4-1" }, "locus": { "chromosome": "29", "start_pos": 41738045, "end_pos": 41708650, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034938.6", "url": "https://www.ensembl.org/id/ENSBTAT00000034938.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034822.4", "url": "https://www.ensembl.org/id/ENSBTAP00000034822.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517475", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517475", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "F1MGV4", "url": "https://www.uniprot.org/uniprotkb/F1MGV4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane transporter activity", "id": "GO:0022857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022857", "evidence": [ { "database": "UniProtKB", "id": "F1MGV4", "url": "https://www.uniprot.org/uniprotkb/F1MGV4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "organic anion transport", "id": "GO:0015711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015711", "evidence": [ { "database": "UniProtKB", "id": "F1MGV4", "url": "https://www.uniprot.org/uniprotkb/F1MGV4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 102, "end_pos": 104, "annotation": "n_glycosylation_sequon" }, { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MGV4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 552, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MGV4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MGV4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MGV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGV4" }, { "id": "PS50850", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50850" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Major facilitator superfamily (MFS) profile", "eco_id": "ECO_0000259", "start_pos": 96, "end_pos": 520, "start_aa": "Trp", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 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"id": "GO:0032794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032794", "evidence": [ { "database": "UniProtKB", "id": "F1MGX4", "url": "https://www.uniprot.org/uniprotkb/F1MGX4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "F1MGX4", "url": "https://www.uniprot.org/uniprotkb/F1MGX4" } ], "pmid": "" }, { "name": "regulation of cell morphogenesis", "id": "GO:0022604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022604", "evidence": [ { "database": "UniProtKB", "id": "F1MGX4", "url": "https://www.uniprot.org/uniprotkb/F1MGX4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 423, "end_pos": 425, "annotation": "n_glycosylation_sequon" }, { "start_pos": 869, "end_pos": 871, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MGX4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1124, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MGX4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MGX4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MGX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX4" }, { "id": "PS51231", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51231" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DAD", "eco_id": "ECO_0000259", "start_pos": 1079, "end_pos": 1112, "start_aa": "Gly", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MGX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX4" }, { "id": "PS51444", 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"MAPHPSCAPPVQVTHETEQRFPGASDDAVTCVASTPPSPTRVLENFTETEGGACRGASRKLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSLYGLEPLAPPCEELASPDSGSPGDWGSLYSPVSQAGSLSPAASLEDRPGLQAPVSPACLHPGALAFSDFL", "length": 215, "header": "tr|F1MGY3-1|F1MGY3_BOVIN Isoform 1 of Neurogenin 3 OS=Bos taurus OX=9913 GN=NEUROG3 PE=4 SV=2 CANONICAL=F1MGY3-1" }, "isoforms": [ { "isoform_ac": "F1MGY3-1", "url": "https://www.uniprot.org/uniprotkb/F1MGY3/entry", "sequence": { "sequence": "MAPHPSCAPPVQVTHETEQRFPGASDDAVTCVASTPPSPTRVLENFTETEGGACRGASRKLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSLYGLEPLAPPCEELASPDSGSPGDWGSLYSPVSQAGSLSPAASLEDRPGLQAPVSPACLHPGALAFSDFL", "length": 215, "header": "tr|F1MGY3-1|F1MGY3_BOVIN Isoform 1 of Neurogenin 3 OS=Bos taurus OX=9913 GN=NEUROG3 PE=4 SV=2 CANONICAL=F1MGY3-1" }, "locus": { "chromosome": "28", "start_pos": 25906779, "end_pos": 25906135, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": 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"common_name": "Pig" }, { "uniprot_canonical_ac": "G3H6T2-1", "protein_name": "Neurogenin-3", "gene_name": "Neurog3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAPHPLGAPTIQVPRETQQPFSGALDNEVLSSKSTLPSPTLMSRDCSEAEAGDCRGTSRKFRTRRGGRNRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSFYGPEPPVPCGELGSPGGGSNGDWGSLYSPVSQAGSLSPTASLEEFPGLQVPSSPSCLLPGALVFSDFL", "length": 214 }, "evidence": [ { "id": "F1MGY3", "url": "https://omabrowser.org/oma/group/F1MGY3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O08718-1", "protein_name": "Neurogenin 3", "gene_name": "Neurog3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPHPLDAPTIQVSQETQQPFPGASDHEVLSSNSTPPSPTLVPRDCSEAEAGDCRGTSRKLRARRGGRNRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSFYGPEPPVPCGELGSPGGGSSGDWGSIYSPVSQAGSLSPTASLEEFPGLQVPSSPSCLLPGTLVFSDFL", "length": 214 }, "evidence": [ { "id": "F1MGY3", "url": "https://omabrowser.org/oma/group/F1MGY3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P70661-1", "protein_name": "Neurogenin-3", "gene_name": "Neurog3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPHPLDALTIQVSPETQQPFPGASDHEVLSSNSTPPSPTLIPRDCSEAEVGDCRGTSRKLRARRGGRNRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSFYGPEPPVPCGELGSPGGGSNGDWGSIYSPVSQAGNLSPTASLEEFPGLQVPSSPSYLLPGALVFSDFL", "length": 214 }, "evidence": [ { "id": "F1MGY3", "url": "https://omabrowser.org/oma/group/F1MGY3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y4Z2-1", "protein_name": "Neurogenin-3", "gene_name": "NEUROG3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRKLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSLYALEPPAPHCGELGSPGGSPGDWGSLYSPVSQAGSLSPAASLEERPGLLGATFSACLSPGSLAFSDFL", "length": 214 }, "evidence": [ { "id": "F1MGY3", "url": "https://omabrowser.org/oma/group/F1MGY3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MGY3", "url": "https://www.uniprot.org/uniprotkb/F1MGY3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MGY3", "url": "https://www.uniprot.org/uniprotkb/F1MGY3" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1MGY3", "url": "https://www.uniprot.org/uniprotkb/F1MGY3" } ], "pmid": "" }, { "name": "transdifferentiation", "id": "GO:0060290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060290", "evidence": [ { "database": "UniProtKB", "id": "F1MGY3", "url": "https://www.uniprot.org/uniprotkb/F1MGY3" } ], "pmid": "" }, { "name": "axon development", "id": "GO:0061564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061564", "evidence": [ { "database": "UniProtKB", "id": "F1MGY3", "url": "https://www.uniprot.org/uniprotkb/F1MGY3" } ], "pmid": "" }, { "name": "enteroendocrine cell differentiation", "id": "GO:0035883", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035883", "evidence": [ { "database": "UniProtKB", "id": "F1MGY3", "url": "https://www.uniprot.org/uniprotkb/F1MGY3" } ], "pmid": "" }, { "name": "sensory organ development", "id": "GO:0007423", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007423", "evidence": [ { "database": "UniProtKB", "id": "F1MGY3", "url": "https://www.uniprot.org/uniprotkb/F1MGY3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "F1MGY3", "url": "https://www.uniprot.org/uniprotkb/F1MGY3" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "F1MGY3", "url": "https://www.uniprot.org/uniprotkb/F1MGY3" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1MGY3", "url": "https://www.uniprot.org/uniprotkb/F1MGY3" } ], "pmid": "" }, { "name": "chromatin DNA binding", "id": "GO:0031490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "evidence": [ { "database": "UniProtKB", "id": "F1MGY3", "url": "https://www.uniprot.org/uniprotkb/F1MGY3" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "F1MGY3", "url": "https://www.uniprot.org/uniprotkb/F1MGY3" } ], "pmid": "" }, { "name": "E-box binding", "id": "GO:0070888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070888", "evidence": [ { "database": "UniProtKB", "id": "F1MGY3", "url": "https://www.uniprot.org/uniprotkb/F1MGY3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MGY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGY3" }, { "id": "PS50888", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50888" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BHLH", "eco_id": "ECO_0000259", "start_pos": 83, "end_pos": 135, "start_aa": "Ser", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 45, "end_pos": 47 } ] }, "class_list": [], "section_stats": 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"sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGY9-1", "uniprot_ac": "F1MGY9", "uniprot_id": "F1MGY9_BOVIN", "mass": { "chemical_mass": 36965.0, "monoisotopic_mass": 36965.0 }, "refseq": { "ac": "XP_005226002", "name": "N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226002" }, "gene_names": [ { "name": "AGA", "type": "recommended", "evidence": [ { "id": "F1MGY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGY9" } ] }, { "name": "AGA", "type": "synonym", "evidence": [ { "id": "XP_005226002", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226002" } ] } ], "protein_names": [ { "name": "N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase", "type": "recommended", "evidence": [ { "id": "F1MGY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGY9/entry#names_and_taxonomy" } ] }, { "name": 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"https://www.uniprot.org/uniprotkb/F1MGY9", "locus": { "chromosome": "27", "start_pos": 8686715, "end_pos": 8698284, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000017085", "url": "https://www.ensembl.org/id/ENSBTAG00000017085" } ] } } ], "crossref": [ { "id": "F1MGY9", "url": "https://alphafold.ebi.ac.uk/entry/F1MGY9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000017085", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000017085", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04513", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04513", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511345", "url": "https://www.ncbi.nlm.nih.gov/gene/511345", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000246", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000246", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YKPIINI", "url": "https://omabrowser.org/oma/group/YKPIINI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MGY9", "url": "https://www.orthodb.org/?gene=F1MGY9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10188", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10188", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10188:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10188:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01112", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01112", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005226002", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226002", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11544", "url": "https://www.rhea-db.org/rhea/11544", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MGY9", "url": "https://www.uniprot.org/uniprotkb/F1MGY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGY9-1", "url": "https://www.uniprot.org/uniprotkb/F1MGY9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAWKPGLLLPLLLLLLGPAPARSFGQLPLVLNTWPFRNATVAAWKTLAAGGSALDAVESGCATCEQQQCDGSVGFGGSPDESGETTLDAMIMDGTTMNVGAVGDLRRIKNAIGVARKVLEHTTHTLLAGEAATKFAESMGFINEDLSTNVSQALHSDWRARNCQPNYWKNVIPDSSKYCGPYKPPTVLKRDGITYEDTAQSYGHDTIGMVVIHKTGNIAAGTSTNGIKFKIPGRIGDSPIPGSGAYADDMVGAAAATGDGDILMRFVPSYQAVEYMRRGENPTTACEKVISRIQKYFPKFFGAVICANVTGSYGAACNKLSTFTQFPFMVYNPLKSAPTEEKVDCI", "length": 346, "header": "tr|F1MGY9-1|F1MGY9_BOVIN Isoform 1 of N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase OS=Bos taurus OX=9913 GN=AGA PE=3 SV=2 CANONICAL=F1MGY9-1" }, "isoforms": [ { "isoform_ac": "F1MGY9-1", "url": "https://www.uniprot.org/uniprotkb/F1MGY9/entry", "sequence": { "sequence": "MAWKPGLLLPLLLLLLGPAPARSFGQLPLVLNTWPFRNATVAAWKTLAAGGSALDAVESGCATCEQQQCDGSVGFGGSPDESGETTLDAMIMDGTTMNVGAVGDLRRIKNAIGVARKVLEHTTHTLLAGEAATKFAESMGFINEDLSTNVSQALHSDWRARNCQPNYWKNVIPDSSKYCGPYKPPTVLKRDGITYEDTAQSYGHDTIGMVVIHKTGNIAAGTSTNGIKFKIPGRIGDSPIPGSGAYADDMVGAAAATGDGDILMRFVPSYQAVEYMRRGENPTTACEKVISRIQKYFPKFFGAVICANVTGSYGAACNKLSTFTQFPFMVYNPLKSAPTEEKVDCI", "length": 346, "header": "tr|F1MGY9-1|F1MGY9_BOVIN Isoform 1 of N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase OS=Bos taurus OX=9913 GN=AGA PE=3 SV=2 CANONICAL=F1MGY9-1" }, "locus": { "chromosome": "27", "start_pos": 8698062, "end_pos": 8686868, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022716.4", "url": "https://www.ensembl.org/id/ENSBTAT00000022716.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022716.3", "url": "https://www.ensembl.org/id/ENSBTAP00000022716.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NQI0-1", "protein_name": "N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase", "gene_name": "AGA", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVAGCASLLLIALQLAGPCGAAATALPVVINTWAFRKATETAWRTLQLGGSELDAVEKGCGQCEIDQCDGSVGYGGSPDESGETTLDAMIMDGNTMEVGAVADLRHVKNAIGVARKVIEHTKHTLLVGESASLFAVRMGFPYEDLTTQRSLSMYSRWLNQSCQPNYWKNVVPDSSKSCGPYKRLEKVSFEEETISQRNVHNHDTIGMVVIGKSGTVASGTSTNGGVHKIPGRVGDSPIAGAGSYADSTAGGAAATGDGDTMMRFLPSYQAVEYMRMGTDPTVACQKVISRIQKHVPKFFGAVICANTTGSYGAACNKIPGFTQFHFMVFSPLQSQPVEQVVDCI", "length": 345 }, "evidence": [ { "id": "F1MGY9", "url": "https://omabrowser.org/oma/group/F1MGY9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RT17-1", "protein_name": "N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase", "gene_name": "AGA", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAQKPILLLMLLLGAAPVRSSSPLPLIVNTWPFRNATQAAWRTLASGGSALDAVESGCAACEREQCDGTVGFGGSPDESGETTLDAMIMDGTTMNVGAVGDLRRIKNAIGVARKVLEHTTHTLLAGEAATKFAESMGFINEDLSTSVSQALHADWLAQNCQPNYWRNVIPDASKYCGPYKPPNILKRDGSTYKETGDSYGHDTIGMVVIHKMGYTAAGTSTNGIKFKIPGRIGDSPIPGSGAYADDTAGAAAATGDGDILMRFLPSYQAVEYMRRGKDPTTACQKVISRIQKYFPNFFGAVICANVTGSYGAACNKLSTFTQFHFMVYNSLKSEPTEEIVDCI", "length": 343 }, "evidence": [ { "id": "F1MGY9", "url": "https://omabrowser.org/oma/group/F1MGY9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HGM6-1", "protein_name": "N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase", "gene_name": "Aga", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MARKLSRSLLLLLPFLLGVPLAQGFSPLPLVLNTWPFKNATDAAWRTLVSGGTAVDAVENGCAVCETERCEGTVGFGGSPDEVGETTLDAMIMDGATMNVGAVGDLRRIKNAIGVARRVLDHTTHTLLVGDSATNFAESMGFTVEDLSTTTSKSLHSEWASKNCQPNFWRRVTPDPSKYCGPYKPSGSLEWAISAHKQVDIHNHDTIGMVVIHKTGHVAAGTSTNGLKFKIPGRVGDSPIPGAGAYAEDMIGAAAATGDGDILMRFLPSYQAVEYMRRGDHPTTACQKVIAKIQKYFPKFFGAIICANVMGSYGAACNKHPTFTQFSFMVYNSLRIQPTEEKVDCI", "length": 346 }, "evidence": [ { "id": "F1MGY9", "url": "https://omabrowser.org/oma/group/F1MGY9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P20933-1", "protein_name": "N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase", "gene_name": "AGA", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARKSNLPVLLVPFLLCQALVRCSSPLPLVVNTWPFKNATEAAWRALASGGSALDAVESGCAMCEREQCDGSVGFGGSPDELGETTLDAMIMDGTTMDVGAVGDLRRIKNAIGVARKVLEHTTHTLLVGESATTFAQSMGFINEDLSTTASQALHSDWLARNCQPNYWRNVIPDPSKYCGPYKPPGILKQDIPIHKETEDDRGHDTIGMVVIHKTGHIAAGTSTNGIKFKIHGRVGDSPIPGAGAYADDTAGAAAATGNGDILMRFLPSYQAVEYMRRGEDPTIACQKVISRIQKHFPEFFGAVICANVTGSYGAACNKLSTFTQFSFMVYNSEKNQPTEEKVDCI", "length": 346 }, "evidence": [ { "id": "F1MGY9", "url": "https://omabrowser.org/oma/group/F1MGY9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P30919-1", "protein_name": "N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase", "gene_name": "Aga", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARKWNLPFLLLPLVLGIPLVRGSNPLPLVVNTWPFKNATEAAWWTLVSGGSALDAVEKGCAMCEKEQCGGTVGFGGSPDEVGETTLDAMIMDGTAMDVGAVGGLRRIKNAIGVARKVLEHTTHTLLVGDSATKFAVSMGFTSEDLSTNTSRALHSDWLSRNCQPNYWRNVIPDPSKYCGPYKPPDFLEQNNRAHKEVDIHSHDTIGMVVIHKTGHTAAGTSTNGLKFKIPGRVGDSPIPGAGAYADDMAGAAAATGDGDTLLRFLPSYQAVEYMRGGDDPARACQKVISRIQKYYPKFFGAVICANVTGSYGAACNRLPTFTQFSFMVYNSLHNQAIEEKVDCM", "length": 345 }, "evidence": [ { "id": "F1MGY9", "url": "https://omabrowser.org/oma/group/F1MGY9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q56W64-1", "protein_name": "Probable isoaspartyl peptidase/L-asparaginase 3", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MARSDVLIFVSTLLLFLSLLTVADAELVKSDKFPVVVSTWPFLEAVRAAWRAVDNGSSAVEAVVEGCSACEELRCDGTVGPGGSPDENGETMIDALVMDGVTMEVGAVAAMRYVKDGIRAAHLVMKYSQHTLLAGEGASAFAISMGLPGPMNLSSPESVKKWSDWKENQCQPNFRKNVVPANDCGPYKPNNSAMNVFVDKSTESCEMGAIEYKPPLVGPHNHDTISMAVIDRMGHIAVGTSTNGATYKIPGRVGDGPIVGSSAYADDEVGGCGATGDGDTMMRFLPCYQVVESMRQGMKPEEAAKDAISRIARKFPDFVGAVVAVDKNGSHAGACYGWTFQYSVQNPDMNDVQVFTVLP", "length": 359 }, "evidence": [ { "id": "F1MGY9", "url": "https://omabrowser.org/oma/group/F1MGY9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q64191-1", "protein_name": "N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase", "gene_name": "Aga", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERKSNLSLLLLLLVLGMPLVRGSSPLPLVVNTWPFKNATEAAWWTLLSGGSALDAVENGCAVCEKEQCDGTVGFGGSPDEGGETTLDAMIMDGTAMDVGAVGGLRRIKNAIGVARRVLEHTTHTLLVGDSATKFAESMGFTNEDLSTKTSRDLHSDWLSRNCQPNYWRNVIPDPSKYCGPYKPSGFLKQSISPHKEEVDIHSHDTIGMVVIHKTGHTAAGTSTNGIKFKIPGRVGDSPIPGAGAYADDTAGAAAATGDGDTLLRFLPSYQAVEYMRGGDDPAIACQKVILRIQKYYPNFFGAVICASVNGSYGAACNKLPTFTQFSFMVSNSLHNEPTEKKVDCI", "length": 346 }, "evidence": [ { "id": "F1MGY9", "url": "https://omabrowser.org/oma/group/F1MGY9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8MR45-1", "protein_name": "Putative N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase CG1827", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MRRHLRASLWILCLATMAFSILAAVNTSPKPTLTSAFSGKAGTTAVKANKTTGELLPMVINTWNFTAANVLAWRILKQSKGGLRQTRNAVVEGCSKCEKLQCDRTVGYGGSPDELGETTLDAMVMDGATMDVGAVAGLRRIKDAIKVARHVLEHTQHTMLVGDAASAFANAMGFESESLVTPESKDMWLQWTAENCQPNFWKNVHPDPKVSCGPYKPRPTPLTRWKEDRARNEYEIGRKNHDTIGMIAIDVESNIHAGTSTNGARHKIPGRVGDSPIPGAGAYADNEVGAAVATGDGDVMMRFLPSLLAVETMRAGKPPAEAAQEGLRRILKHHKDFMGALIAVDRLGNYGAACYGLAEFPFMVSSPAGADGPTRLETVKCIGGQDKVNIVAL", "length": 393 }, "evidence": [ { "id": "F1MGY9", "url": "https://omabrowser.org/oma/group/F1MGY9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1MGY9", "url": "https://www.uniprot.org/uniprotkb/F1MGY9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MGY9", "url": "https://www.uniprot.org/uniprotkb/F1MGY9" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1MGY9", "url": "https://www.uniprot.org/uniprotkb/F1MGY9" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "F1MGY9", "url": "https://www.uniprot.org/uniprotkb/F1MGY9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1MGY9", "url": "https://www.uniprot.org/uniprotkb/F1MGY9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "peptidase activity", "id": "GO:0008233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008233", "evidence": [ { "database": "UniProtKB", "id": "F1MGY9", "url": "https://www.uniprot.org/uniprotkb/F1MGY9" } ], "pmid": "" }, { "name": "N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity", "id": "GO:0003948", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003948", "evidence": [ { "database": "UniProtKB", "id": "F1MGY9", "url": "https://www.uniprot.org/uniprotkb/F1MGY9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 149, "end_pos": 151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 308, "end_pos": 310, "annotation": "n_glycosylation_sequon" }, { "start_pos": 38, "end_pos": 40, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11544", "name": "", "equation": "N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MGY9-1" ], "evidence": [ { "id": "11544", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11544" } ] }, { "id": "R-BTA-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, azurophil granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O77834-1", "Q29451-1", "P07514-1", "A0JNA3-1", "Q32PF2-1", "Q3MI05-1", "F1MUP9-1", "H7BWW2-1", "Q08DD1-1", "Q2KIM0-1", "Q3ZBH0-1", "F1MU24-1", "A0AAA9U1E9-1", "A0ABI0NJH4-1", "F1N144-1", "F1N5H2-1", "P80189-1", "P46196-1", "A7YWG4-1", "E1BPI3-1", "A0AAA9SWY4-1", "A0A3Q1LUG9-1", "F1MGY9-1", "G3X757-1", "A0A3Q1NDQ7-1", "Q2KJ64-1", "Q3ZCI9-1", "E1B725-1" ], "evidence": [ { "id": "R-BTA-6798751", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798751" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUG9", "gene_name": "TXNDC5", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "A0A3Q1LUG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "A0A3Q1LUG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUG9" } ] } ] }, { "uniprot_ac": "A0A3Q1NDQ7", "gene_name": "GLB1", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "A0A3Q1NDQ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NDQ7" } ] } ] }, { "uniprot_ac": "A0AAA9SWY4", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9SWY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWY4" } ] } ] }, { "uniprot_ac": "A0AAA9U1E9", "gene_name": "GALNS", "activity": [ { "ec_number": "3.1.6.4", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.", "evidence": [ { "id": "A0AAA9U1E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1E9" } ] }, { "ec_number": "3.1.6.4", "activity": "", "evidence": [ { "id": "A0AAA9U1E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1E9" } ] } ] }, { "uniprot_ac": "A0ABI0NJH4", "gene_name": "GNS", "activity": [ { "ec_number": "3.1.6.14", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] }, { "ec_number": "3.1.6.14", "activity": "", "evidence": [ { "id": "A0ABI0NJH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJH4" } ] } ] }, { "uniprot_ac": "A0JNA3", "gene_name": "IMPDH1", "activity": [ { "ec_number": "1.1.1.205", "activity": "IMP + NAD(+) + H2O = XMP + NADH + H(+).", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "A0JNA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNA3" } ] } ] }, { "uniprot_ac": "A7YWG4", "gene_name": "GGH", "activity": [ { "ec_number": "3.4.19.9", "activity": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate.", "evidence": [ { "id": "A7YWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWG4" } ] }, { "ec_number": "3.4.19.9", "activity": "", "evidence": [ { "id": "A7YWG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YWG4" } ] } ] }, { "uniprot_ac": "E1B725", "gene_name": "GLA", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "E1B725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B725" } ] } ] }, { "uniprot_ac": "E1BPI3", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E1BPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPI3" } ] } ] }, { "uniprot_ac": "F1MGY9", "gene_name": "AGA", "activity": [ { "ec_number": "3.5.1.26", "activity": 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"https://www.reactome.org/PathwayBrowser/#R-BTA-2162123", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059743713", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743713", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10600", "url": "https://www.rhea-db.org/rhea/10600", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "16437", "url": "https://www.rhea-db.org/rhea/16437", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "51232", "url": "https://www.rhea-db.org/rhea/51232", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MGZ9", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGZ9-1", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPNYKLIYFNMRGRAEIIRYIFAYLDIKYEDHRIEQADWPEIKSTLPFGKIPILEVDGLNLHQSLAIARYLTRNTDLAGKTELEQCQVDAIVDTLDDFMSRFPWTEKRQDIKNQIFKELLTCDAPPLLQNLDTYLGENEWLIGDSVTWADFYWEICSTTLLVFKSDLLDIHPRLVTLRKKVQSIPAIADWILRRPQTKL", "length": 199, "header": "tr|F1MGZ9-1|F1MGZ9_BOVIN Isoform 1 of Hematopoietic prostaglandin D synthase OS=Bos taurus OX=9913 GN=HPGDS PE=3 SV=3 CANONICAL=F1MGZ9-1" }, "isoforms": [ { "isoform_ac": "F1MGZ9-1", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9/entry", "sequence": { "sequence": "MPNYKLIYFNMRGRAEIIRYIFAYLDIKYEDHRIEQADWPEIKSTLPFGKIPILEVDGLNLHQSLAIARYLTRNTDLAGKTELEQCQVDAIVDTLDDFMSRFPWTEKRQDIKNQIFKELLTCDAPPLLQNLDTYLGENEWLIGDSVTWADFYWEICSTTLLVFKSDLLDIHPRLVTLRKKVQSIPAIADWILRRPQTKL", "length": 199, "header": "tr|F1MGZ9-1|F1MGZ9_BOVIN Isoform 1 of Hematopoietic prostaglandin D synthase OS=Bos taurus OX=9913 GN=HPGDS PE=3 SV=3 CANONICAL=F1MGZ9-1" }, "locus": { "chromosome": "6", "start_pos": 30303211, "end_pos": 30286544, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022700.8", "url": "https://www.ensembl.org/id/ENSBTAT00000022700.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022700.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022700.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:100139892", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100139892", "resource": "KEGG Pathway" }, { "id": "R-BTA-156590", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-156590", "resource": "Reactome", "description": "Glutathione conjugation" }, { "id": "R-BTA-2162123", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2162123", "resource": "Reactome", "description": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "prostaglandin-D synthase activity", "id": "GO:0004667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004667", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ9", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ], "pmid": "" }, { "name": "glutathione transferase activity", "id": "GO:0004364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004364", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ9", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ9", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ9", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ9", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ9", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "prostaglandin biosynthetic process", "id": "GO:0001516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001516", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ9", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ], "pmid": "" }, { "name": "glutathione metabolic process", "id": "GO:0006749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006749", "evidence": [ { "database": "UniProtKB", "id": "F1MGZ9", "url": "https://www.uniprot.org/uniprotkb/F1MGZ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10600", "name": "", "equation": "prostaglandin H2 = prostaglandin D2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SUW3-1", "O02853-1", "F1MGZ9-1" ], "evidence": [ { "id": "10600", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10600" } ] }, { "id": "16437", "name": "", "equation": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O18879-1", "F1MUX5-1", "F1MX44-1", "A0ABI0P5M0-1", "A0AAA9TW47-1", "F6QEM8-1", "A0ABI0P3R2-1", "A0AAF6Z0W3-1", "P28801-1", "Q2KJG4-1", "A0A3Q1LMV5-1", "F1MVX2-1", "Q28035-1", "Q9N0V4-1", "Q2NL00-1", "F1MXY2-1", "E1BED9-1", "A0ABI0P006-1", "Q5E9G0-1", "Q64L89-1", "A0A452DIU1-1", "F1MGZ9-1", "A0AAA9TXU3-1", "E1BJX2-1" ], "evidence": [ { "id": "16437", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16437" } ] }, { "id": "51232", "name": "", "equation": "2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MGZ9-1" ], "evidence": [ { "id": "51232", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/51232" } ] }, { "id": "R-BTA-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O18879-1", "E1BED9-1", "A0ABI0P006-1", "A0ABI0P5M0-1", "A0A3Q1LMV5-1", "F1MGZ9-1", "F1MUX5-1", "F1MX44-1", "Q2NL00-1", "Q5E9G0-1", "A0A452DIU1-1" ], "evidence": [ { "id": "R-BTA-176054", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-176054" } ] }, { "id": "R-BTA-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MGZ9-1" ], "evidence": [ { "id": "R-BTA-2161701", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2161701" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LMV5", "gene_name": "LOC281806", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A3Q1LMV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMV5" } ] } ] }, { "uniprot_ac": "A0A452DIU1", "gene_name": "LOC327709", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0A452DIU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DIU1" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0A452DIU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A452DIU1" } ] } ] }, { "uniprot_ac": "A0AAA9SUW3", "gene_name": "PTGDS", "activity": [ { "ec_number": "5.3.99.2", "activity": "prostaglandin H2 = prostaglandin D2.", "evidence": [ { "id": "A0AAA9SUW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW3" } ] }, { "ec_number": "5.3.99.2", "activity": "", "evidence": [ { "id": "A0AAA9SUW3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUW3" } ] } ] }, { "uniprot_ac": "A0AAA9TW47", "gene_name": "GSTK1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAA9TW47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TW47" } ] } ] }, { "uniprot_ac": "A0AAA9TXU3", "gene_name": "GSTZ1", "activity": [ { "ec_number": "5.2.1.2", "activity": "4-maleylacetoacetate = 4-fumarylacetoacetate.", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "5.2.1.2", "activity": "", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAA9TXU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXU3" } ] } ] }, { "uniprot_ac": "A0AAF6Z0W3", "gene_name": "LANCL1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0AAF6Z0W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z0W3" } ] } ] }, { "uniprot_ac": "A0ABI0P006", "gene_name": "LOC785216", "activity": [ { "ec_number": "1.20.4.2", "activity": "methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O.", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "1.8.5.1", "activity": "L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate.", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "1.8.5.1", "activity": "", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] }, { "ec_number": "1.20.4.2", "activity": "", "evidence": [ { "id": "A0ABI0P006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P006" } ] } ] }, { "uniprot_ac": "A0ABI0P3R2", "gene_name": "GSTT2", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] }, { "ec_number": "4.1.1.84", "activity": "D-dopachrome + H(+) = 5,6-dihydroxyindole + CO2.", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] }, { "ec_number": "4.1.1.84", "activity": "", "evidence": [ { "id": "A0ABI0P3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3R2" } ] } ] }, { "uniprot_ac": "A0ABI0P5M0", "gene_name": "GSTA1", "activity": [ { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "A0ABI0P5M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5M0" } ] }, { "ec_number": "2.5.1.18", "activity": "", "evidence": [ { "id": "A0ABI0P5M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P5M0" } ] } ] }, { "uniprot_ac": "E1BED9", "gene_name": "GSTO2", "activity": [ { "ec_number": "1.20.4.2", "activity": "methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O.", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "1.8.5.1", "activity": "L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate.", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { "ec_number": "2.5.1.18", "activity": "RX + glutathione = an S-substituted glutathione + a halide anion + H(+).", "evidence": [ { "id": "E1BED9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BED9" } ] }, { 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"MPSFNQSIFHPTVFFLTGIPGFEIYHAWVFIPFCCLYVIAISGNGMILFVIITESSLHEPMYYFLSMLSFSDLGLCLSTLVTMVGIFWFNVREISFDACIGQMFFIHGFTLMESSVLLAMAFDRYIAICNPLRYATILTNSTIIKVGFAIVVRVTTVVVPLLLLLKHLSFCGSHVLHHSYCFHPDVMKLSCTDTKINSAFGLAIVISTAALDSVLILLSYVPIINSVLSIASPEERKKAFGTCVSHISAVAIFYIPTISLSLVHRFGKHAPPLVHTLIANVYLLIPPVMNPIIYSVKTKQIRKAMVKIFLSKLI", "length": 314, "header": "tr|F1MH08-1|F1MH08_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR51F5C PE=3 SV=2 CANONICAL=F1MH08-1" }, "isoforms": [ { "isoform_ac": "F1MH08-1", "url": "https://www.uniprot.org/uniprotkb/F1MH08/entry", "sequence": { "sequence": "MPSFNQSIFHPTVFFLTGIPGFEIYHAWVFIPFCCLYVIAISGNGMILFVIITESSLHEPMYYFLSMLSFSDLGLCLSTLVTMVGIFWFNVREISFDACIGQMFFIHGFTLMESSVLLAMAFDRYIAICNPLRYATILTNSTIIKVGFAIVVRVTTVVVPLLLLLKHLSFCGSHVLHHSYCFHPDVMKLSCTDTKINSAFGLAIVISTAALDSVLILLSYVPIINSVLSIASPEERKKAFGTCVSHISAVAIFYIPTISLSLVHRFGKHAPPLVHTLIANVYLLIPPVMNPIIYSVKTKQIRKAMVKIFLSKLI", "length": 314, "header": "tr|F1MH08-1|F1MH08_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR51F5C PE=3 SV=2 CANONICAL=F1MH08-1" }, "locus": { "chromosome": "15", "start_pos": 50262752, "end_pos": 50261811, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039809.4", "url": "https://www.ensembl.org/id/ENSBTAT00000039809.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039597.3", "url": "https://www.ensembl.org/id/ENSBTAP00000039597.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:518561", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:518561", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MH08", "url": "https://www.uniprot.org/uniprotkb/F1MH08" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1MH08", "url": "https://www.uniprot.org/uniprotkb/F1MH08" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MH08", "url": "https://www.uniprot.org/uniprotkb/F1MH08" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cellular response to lipid", "id": "GO:0071396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071396", "evidence": [ { "database": "UniProtKB", "id": "F1MH08", "url": "https://www.uniprot.org/uniprotkb/F1MH08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MH08-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 314, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MH08-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MH08" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MH08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH08" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 294, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 140, "end_pos": 142 }, { "start_pos": 5, "end_pos": 7 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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{ "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MH09-1", "uniprot_ac": "F1MH09", "uniprot_id": "F1MH09_BOVIN", "mass": { "chemical_mass": 48900.0, "monoisotopic_mass": 48900.0 }, "refseq": { "ac": "XP_059736206", "name": "chorion-specific transcription factor GCMa", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059736206" }, "gene_names": [ { "name": "GCM1", "type": "recommended", "evidence": [ { "id": "F1MH09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH09" } ] }, { "name": "GCM1", "type": "synonym", "evidence": [ { "id": "XP_059736206", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059736206" } ] } ], "protein_names": [ { "name": "Glial cells missing transcription factor 1", "type": "synonym", "evidence": [ { "id": "F1MH09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH09/entry#names_and_taxonomy" } ] }, { "name": "chorion-specific transcription factor GCMa", "type": "synonym", "evidence": [ { "id": "XP_059736206", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059736206" } ] }, { "name": "glial cells missing homolog 1", "type": "synonym", "evidence": [ { "id": "XP_059736206", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059736206" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MH09", "url": "https://www.uniprot.org/uniprotkb/F1MH09" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GCM1", "url": "https://www.uniprot.org/uniprotkb/F1MH09", "locus": { "chromosome": "23", "start_pos": 25311576, "end_pos": 25332914, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008148", "url": "https://www.ensembl.org/id/ENSBTAG00000008148" } ] } } ], "crossref": [ { "id": "F1MH09", "url": "https://alphafold.ebi.ac.uk/entry/F1MH09", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008148", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008148", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "317779", "url": "https://www.ncbi.nlm.nih.gov/gene/317779", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003902", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003902", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036115", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036115", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FPLTNWP", "url": "https://omabrowser.org/oma/group/FPLTNWP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MH09", "url": "https://www.orthodb.org/?gene=F1MH09", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12414", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12414", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12414:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12414:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03615", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03615", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059736206", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059736206", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MH09", "url": "https://www.uniprot.org/uniprotkb/F1MH09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MH09-1", "url": "https://www.uniprot.org/uniprotkb/F1MH09-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPENADSADKELSWDINDMKLPQNVKKTDWFQEWPDAYEKHIYSSDDRNAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCGRDCSVAEGRKVYLRPAICDKARQKQQRKRCPNCDGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPKPETKLEAEARRAVKKTHSASSSVSSKLKQSPEIKPLPGETQSWENLTWSFQEAVQLPPGYSGHVIGYTPQQKAWNDGSSFTESYGLGGTSELANLTPTLGPPQLYDKWDLSHSRVSSSGDLLQPSISGVFSDYSDLQTWNKNVALGRSPLNDNSCPSYPFPLTSWPYDFSPSQSSSEPFHQPVPVEPPAVKSSYPPIWPNQGGELYEEKVPVDFNSYHPPTTCHSPQEDPLLLTHTSQPYHQYALPGKSNKWDFDEEMGCLGLDHCNNEMLLNLCPLR", "length": 433, "header": "tr|F1MH09-1|F1MH09_BOVIN Isoform 1 of Glial cells missing transcription factor 1 OS=Bos taurus OX=9913 GN=GCM1 PE=4 SV=2 CANONICAL=F1MH09-1" }, "isoforms": [ { "isoform_ac": "F1MH09-1", "url": "https://www.uniprot.org/uniprotkb/F1MH09/entry", "sequence": { "sequence": "MEPENADSADKELSWDINDMKLPQNVKKTDWFQEWPDAYEKHIYSSDDRNAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCGRDCSVAEGRKVYLRPAICDKARQKQQRKRCPNCDGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPKPETKLEAEARRAVKKTHSASSSVSSKLKQSPEIKPLPGETQSWENLTWSFQEAVQLPPGYSGHVIGYTPQQKAWNDGSSFTESYGLGGTSELANLTPTLGPPQLYDKWDLSHSRVSSSGDLLQPSISGVFSDYSDLQTWNKNVALGRSPLNDNSCPSYPFPLTSWPYDFSPSQSSSEPFHQPVPVEPPAVKSSYPPIWPNQGGELYEEKVPVDFNSYHPPTTCHSPQEDPLLLTHTSQPYHQYALPGKSNKWDFDEEMGCLGLDHCNNEMLLNLCPLR", "length": 433, "header": "tr|F1MH09-1|F1MH09_BOVIN Isoform 1 of Glial cells missing transcription factor 1 OS=Bos taurus OX=9913 GN=GCM1 PE=4 SV=2 CANONICAL=F1MH09-1" }, "locus": { "chromosome": "23", "start_pos": 25329970, "end_pos": 25312389, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010709.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010709.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010709.5", "url": "https://www.ensembl.org/id/ENSBTAP00000010709.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "G3I5G7-1", "protein_name": "Chorion-specific transcription factor GCMa", "gene_name": "Gcm1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEPDDFDPEDKEILSWDINDMKLPQNVKKTDWFQEWPDSYVKHIYSSDDRNAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCSRDCSTEEGRKIYLRPAICDKARQKQQRKCCPNCNGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPKPETKLEAEARRAMKKVHMASASGSLRMKGSPETKVLPSEIPSQGSLPLTWSFQEGVQLPSSYSTPLIANASQQNSLNDCLSFPKSYDLGGTTELEDPTSTLDPTMLYEKCKFSSSGIYSSEDQFQPPVPGVYTDYDDLQAWNKNASLGRNPNDDTCYPNYPLPVSSWPCDFFPSQNSLEHFPQQIPLEAAAAQTGCHPLWSNPGGEPYEEKVPMDFNSYVPSLTYHSPQQDPFLLSYGSHPQQQYSLPSKNSKWDFEEEVACTGLDHFNNEMFLNLCPLR", "length": 436 }, "evidence": [ { "id": "F1MH09", "url": "https://omabrowser.org/oma/group/F1MH09/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P70348-1", "protein_name": "Chorion-specific transcription factor GCMa", "gene_name": "Gcm1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELDDFDPEDKEILSWDINDVKLPQNVKTTDWFQEWPDSYVKHIYSSDDRNAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCSRDCSTEEGRKIYLRPAICDKARQKQQRKSCPNCNGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPRPETKLEAEARRAMKKVHMASASNSLRMKGRPAAKALPAEIPSQGSLPLTWSFQEGVQLPGTYSTPLIANAPQQNSLNDCLSFPKSYDLGGSTELEDPTSTLDSMKFYERCKFSSSRIYGSEEQFQPPVPGTYGDYEDLQTWNKNVALGRNPSDDIYYPAYPLPVASWPYDYFPSQNSLEHLPQQVPSEPPAAQPGCHPLWSNPGGEPYEEKVSVDLSSYVPSLTYHPPQQDPFLLTYGSPTQQQHALPGKSNRWDFDEEMACMGLDHFNNEMLLNFCSLR", "length": 436 }, "evidence": [ { "id": "F1MH09", "url": "https://omabrowser.org/oma/group/F1MH09/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NP62-1", "protein_name": "Chorion-specific transcription factor GCMa", "gene_name": "GCM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPDDFDSEDKEILSWDINDVKLPQNVKKTDWFQEWPDSYAKHIYSSEDKNAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCGRDCLAEEGRKIYLRPAICDKARQKQQRKRCPNCDGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPKPETKLEAEARRAMKKVNTAPSSVSLSLKGSTETRSLPGETQSQGSLPLTWSFQEGVQLPGSYSGHLIANTPQQNSLNDCFSFSKSYGLGGITDLTDQTSTVDPMKLYEKRKLSSSRTYSSGDLLPPSASGVYSDHGDLQAWSKNAALGRNHLADNCYSNYPFPLTSWPCSFSPSQNSSEPFYQQLPLEPPAAKTGCPPLWPNPAGNLYEEKVHVDFNSYVQSPAYHSPQEDPFLFTYASHPHQQYSLPSKSSKWDFEEEMTYLGLDHCNNDMLLNLCPLR", "length": 436 }, "evidence": [ { "id": "F1MH09", "url": "https://omabrowser.org/oma/group/F1MH09/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z288-1", "protein_name": "Chorion-specific transcription factor GCMa", "gene_name": "Gcm1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"Protein Classification" ] }, { "id": "THPEQPF", "url": "https://omabrowser.org/oma/group/THPEQPF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MHF1", "url": "https://www.orthodb.org/?gene=F1MHF1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46059", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46059", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46059:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46059:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00777", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00777", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "52104", "url": "https://www.rhea-db.org/rhea/52104", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "82947", "url": "https://www.rhea-db.org/rhea/82947", "database": "Rhea", 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"categories": [ "Enzyme and Pathway" ] }, { "id": "F1MHF1", "url": "https://www.uniprot.org/uniprotkb/F1MHF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHF1-1", "url": "https://www.uniprot.org/uniprotkb/F1MHF1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTRTSLKKKVFSCCVLIFLLFAIICVWKEKKKGNYYEFLKLQNKEYQVLQGLEKLAVSSSSQPVSSSSTHNPQRNIQALGGPKAKLKATFQVWDKDSSSKNLAPRLQTIRKNYLNMNKYKVTYKGPGPGVKFSAEALLCHLRDHVNISMIEATDFPFNTSDWEGYLPQEDIRTKAGPWGRCAVVSSAGSLKSSRLGREIDDHDAVLRFNGAPTVKFQQDVGTKTTIRLVNSQLVTTEAGFLKDSLYNEGILIVWDPSVYHSDIPKWYRNPDYSFFNNFKSYRKLHPDQPFYILKPQMPWELWDIIQEISSELIQPNPPSSGMLGIAIMMSLCDQVDIYEFLPSKRKTDVCYYYQRYFDSACTMGAYHPLLFEKNMVKYLNLGTDEDIYLLGKATLPGFRTIRCGA", "length": 405, "header": "tr|F1MHF1-1|F1MHF1_BOVIN Isoform 1 of Beta-galactoside alpha-2,6-sialyltransferase 1 OS=Bos taurus OX=9913 GN=ST6GAL1 PE=3 SV=3 CANONICAL=F1MHF1-1" }, "isoforms": [ { "isoform_ac": "F1MHF1-1", "url": "https://www.uniprot.org/uniprotkb/F1MHF1/entry", "sequence": { "sequence": "MTRTSLKKKVFSCCVLIFLLFAIICVWKEKKKGNYYEFLKLQNKEYQVLQGLEKLAVSSSSQPVSSSSTHNPQRNIQALGGPKAKLKATFQVWDKDSSSKNLAPRLQTIRKNYLNMNKYKVTYKGPGPGVKFSAEALLCHLRDHVNISMIEATDFPFNTSDWEGYLPQEDIRTKAGPWGRCAVVSSAGSLKSSRLGREIDDHDAVLRFNGAPTVKFQQDVGTKTTIRLVNSQLVTTEAGFLKDSLYNEGILIVWDPSVYHSDIPKWYRNPDYSFFNNFKSYRKLHPDQPFYILKPQMPWELWDIIQEISSELIQPNPPSSGMLGIAIMMSLCDQVDIYEFLPSKRKTDVCYYYQRYFDSACTMGAYHPLLFEKNMVKYLNLGTDEDIYLLGKATLPGFRTIRCGA", "length": 405, "header": "tr|F1MHF1-1|F1MHF1_BOVIN Isoform 1 of Beta-galactoside alpha-2,6-sialyltransferase 1 OS=Bos taurus OX=9913 GN=ST6GAL1 PE=3 SV=3 CANONICAL=F1MHF1-1" }, "locus": { "chromosome": "1", "start_pos": 80233920, "end_pos": 80197434, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012565.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012565.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012565.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012565.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "P13721-1", "protein_name": "Beta-galactoside alpha-2,6-sialyltransferase 1", "gene_name": "St6gal1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MIHTNLKKKFSLFILVFLLFAVICVWKKGSDYEALTLQAKEFQMPKSQEKVAMGSASQVVFSNSKQDPKEDIPILSYHRVTAKVKPQPSFQVWDKDSTYSKLNPRLLKIWRNYLNMNKYKVSYKGPGPGVKFSVEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKVGPWQRCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSQLVTTEKRFLKDSLYTEGILIVWDPSVYHADIPKWYQKPDYNFFETYKSYRRLNPSQPFYILKPQMPWELWDIIQEISADLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPLLFEKNMVKHLNEGTDEDIYLFGKATLSGFRNIRC", "length": 403 }, "evidence": [ { "id": "F1MHF1", "url": "https://omabrowser.org/oma/group/F1MHF1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P15907-1", "protein_name": "Beta-galactoside alpha-2,6-sialyltransferase 1", "gene_name": "ST6GAL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIHTNLKKKFSCCVLVFLLFAVICVWKEKKKGSYYDSFKLQTKEFQVLKSLGKLAMGSDSQSVSSSSTQDPHRGRQTLGSLRGLAKAKPEASFQVWNKDSSSKNLIPRLQKIWKNYLSMNKYKVSYKGPGPGIKFSAEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHLNQGTDEDIYLLGKATLPGFRTIHC", "length": 406 }, "evidence": [ { "id": "F1MHF1", "url": "https://omabrowser.org/oma/group/F1MHF1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q64685-1", "protein_name": "Beta-galactoside alpha-2,6-sialyltransferase 1", "gene_name": "St6gal1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIHTNLKRKFSCFVLVFLLFAIICVWKKGSDYEALTLQAKVFQMPKSQEKVAVGPAPQAVFSNSKQDPKEGVQILSYPRVTAKVKPQPSLQVWDKDSTYSKLNPRLLKIWRNYLNMNKYKVSYKGPGPGVKFSVEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKAGPWHKCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGTKTTIRLVNSQLVTTEKRFLKDSLYTEGILILWDPSVYHADIPQWYQKPDYNFFETYKSYRRLHPSQPFYILKPQMPWELWDIIQEISPDLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPLLFEKNMVKHLNEGTDEDIYLFGKATLSGFRNNRC", "length": 403 }, "evidence": [ { "id": "F1MHF1", "url": "https://omabrowser.org/oma/group/F1MHF1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92182-1", "protein_name": "Beta-galactoside alpha-2,6-sialyltransferase 1", "gene_name": "ST6GAL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVHINVLKKFMCVLVVILIALTVCLWKETRGSYYVPLKNDGTQVHRALDKWNLLKSQGLLHEAAGEMGQMPKALPNNQNKVKGITSGAVEKSRKAAEHVKVWDKDSSSRNLIPRLQKVRKNYLSMNKYNVTYNGKMNAAKLSPEQLLCRLRDRVNVTMIRGSDGPFNSSEWQHYLPDKSLNETVGRLGRCAVVSSAGSLKSSHLGPEIDSHDAVLRFNGAPVKGFQEDVGQKTTIRLVNSQLVTVEEQQFLKDALYNTGILIVWDPAPYHAEIHEWYRKPDYKFFEAYKSYRIRHPEQPFYILNPKMQWQLWDILQENSLEHIQPNPPSSGMLGIVIMMTLCDEVDVYEFLPSKRQTDICHYYQKFHDHACTMGAYHPLLFEKNLVKHLNQGTDEDIYTHGKVTLPGFRNVHC", "length": 413 }, "evidence": [ { "id": "F1MHF1", "url": "https://omabrowser.org/oma/group/F1MHF1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "N-acetylneuraminate metabolic process", "id": "GO:0006054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006054", "evidence": [ { "database": "UniProtKB", "id": "F1MHF1", "url": "https://www.uniprot.org/uniprotkb/F1MHF1" } ], "pmid": "" }, { "name": "protein N-linked glycosylation", "id": "GO:0006487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006487", "evidence": [ { "database": "UniProtKB", "id": "F1MHF1", "url": "https://www.uniprot.org/uniprotkb/F1MHF1" } ], "pmid": "" }, { "name": "sialylation", "id": "GO:0097503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097503", "evidence": [ { "database": "UniProtKB", "id": "F1MHF1", "url": "https://www.uniprot.org/uniprotkb/F1MHF1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F1MHF1", "url": "https://www.uniprot.org/uniprotkb/F1MHF1" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MHF1", "url": "https://www.uniprot.org/uniprotkb/F1MHF1" } ], "pmid": "" }, { "name": "Golgi cisterna membrane", "id": "GO:0032580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "evidence": [ { "database": "UniProtKB", "id": "F1MHF1", "url": "https://www.uniprot.org/uniprotkb/F1MHF1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1MHF1", "url": "https://www.uniprot.org/uniprotkb/F1MHF1" } ], "pmid": "" }, { "name": "beta-galactoside alpha-2,6-sialyltransferase activity", "id": "GO:0003835", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003835", "evidence": [ { "database": "UniProtKB", "id": "F1MHF1", "url": "https://www.uniprot.org/uniprotkb/F1MHF1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "52104", "name": "", "equation": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHF1-1", "A5D7T4-1" ], "evidence": [ { "id": "52104", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52104" } ] }, { "id": "82947", "name": "", "equation": "an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHF1-1" ], "evidence": [ { "id": "82947", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/82947" } ] }, { "id": "83927", "name": "", "equation": "an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHF1-1" ], "evidence": [ { "id": "83927", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83927" } ] }, { "id": "83931", "name": "", "equation": "an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHF1-1" ], "evidence": [ { "id": "83931", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/83931" } ] }, { "id": "84035", "name": "", "equation": "an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHF1-1" ], "evidence": [ { "id": "84035", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/84035" } ] }, { "id": "84039", "name": "", "equation": "an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHF1-1" ], "evidence": [ { "id": "84039", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/84039" } ] }, { "id": "84119", "name": "", "equation": "an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHF1-1" ], "evidence": [ { "id": "84119", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/84119" } ] }, { "id": "85275", "name": "", "equation": "an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHF1-1" ], "evidence": [ { "id": "85275", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85275" } ] }, { "id": "85395", "name": "", "equation": "an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHF1-1" ], "evidence": [ { "id": "85395", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85395" } ] }, { "id": "85403", "name": "", "equation": "an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MHF1-1" ], "evidence": [ { "id": "85403", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85403" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A5D7T4", "gene_name": "ST6GAL2", "activity": [ { "ec_number": "2.4.3.1", "activity": "N-acetyllactosamine + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine + CMP + H(+).", "evidence": [ { "id": "A5D7T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7T4" } ] }, { "ec_number": "2.4.3.1", "activity": "", "evidence": [ { "id": "A5D7T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7T4" } ] } ] }, { "uniprot_ac": "F1MHF1", "gene_name": "ST6GAL1", "activity": [ { "ec_number": "2.4.3.1", "activity": "N-acetyllactosamine + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine + CMP + H(+).", "evidence": [ { "id": "F1MHF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHF1" } ] }, { "ec_number": "2.4.3.1", "activity": "", "evidence": [ { "id": "F1MHF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHF1" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MHF1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 405, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MHF1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MHF1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [ { "glytoucan_ac": "G00113FP", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G00321UH", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00330GX", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G00383NC", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00413UF", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00420CS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00480KJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G00514XC", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G00519UD", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G00520NI", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G00646SN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G00662IB", "type": "N-linked", "subtype": "Triantennary" }, { 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"Triantennary" }, { "glytoucan_ac": "G34822AT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G34859KW", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G34964CV", "type": "O-linked", "subtype": "O-fucose core, other" }, { "glytoucan_ac": "G34972BB", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G34983YN", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35087KV", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35307UC", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35565NM", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G35594BH", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35599MZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35632UU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G35655SC", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35698OP", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G35716TV", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G35722YG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G35734AU", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G35798GO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G35986YT", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G36003IA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36020VB", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G36066DO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36092HA", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36157OV", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G36176RV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36218DJ", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G36231CI", "type": "Other", "subtype": "Other" }, { "glytoucan_ac": "G36303CE", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G36316RB", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36343DI", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G36484FP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36521SZ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G36573BV", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G36699YI", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36721QZ", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G36727AR", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36759VO", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36776KM", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36847DS", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G36861QC", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G37183DT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37260FV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37271FP", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G37304XT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G37385TT", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37491LV", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G37492BZ", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G37581LU", "type": "N-linked", "subtype": "Hybrid" }, { "glytoucan_ac": "G37591JC", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G37626KE", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G37884CG", "type": "N-linked", "subtype": "Core-fucosylated" }, { 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"type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39361OH", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G39370XG", "type": "N-linked", "subtype": "Complex" }, { "glytoucan_ac": "G39417RW", "type": "O-linked", "subtype": "Core 3" }, { "glytoucan_ac": "G39461VJ", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G39473HX", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G39504IG", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39531LA", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39549VW", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39600NF", "type": "N-linked", "subtype": "Tetraantennary" }, { "glytoucan_ac": "G39661KT", "type": "N-linked", "subtype": "Triantennary" }, { "glytoucan_ac": "G39691JY", "type": "N-linked", "subtype": "Core-fucosylated" }, { "glytoucan_ac": "G39750GC", "type": "N-linked", "subtype": 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"end_pos": 315, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MHV9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MHV9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.4.2.31", "ec_name": "L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+).", "evidence": [ { "id": "2.4.2.31", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31" }, { "id": "2.4.2.31", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.2.31" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 109, "end_pos": 111 }, { "start_pos": 242, "end_pos": 244 }, { "start_pos": 248, "end_pos": 250 }, { "start_pos": 68, "end_pos": 70 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MHX8-1", "uniprot_ac": "F1MHX8", "uniprot_id": "F1MHX8_BOVIN", "mass": { "chemical_mass": 105725.0, "monoisotopic_mass": 105725.0 }, "refseq": { "ac": "NP_001179811", "name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179811" }, "gene_names": [ { "name": "MDGA1", "type": "recommended", "evidence": [ { "id": "F1MHX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" } ] }, { "name": "MDGA1", "type": "synonym", "evidence": [ { "id": "NP_001179811", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179811" } ] } ], "protein_names": [ { "name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1", "type": "recommended", "evidence": [ { "id": "F1MHX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHX8/entry#names_and_taxonomy" } ] }, { "name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor", "type": "synonym", "evidence": [ { "id": "NP_001179811", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179811" } ] } ], "function": [ { "annotation": "Required for radial migration of cortical neurons in the superficial layer of the neocortex. Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2.", "evidence": [ { "database": "UniProtKB", "id": "F1MHX8", "url": "https://www.uniprot.org/uniprotkb/F1MHX8#function" }, { "database": "UniProtKB", "id": "ARBA00058449", "url": "https://www.uniprot.org/uniprotkb/ARBA00058449#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MHX8", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MDGA1", "url": "https://www.uniprot.org/uniprotkb/F1MHX8", "locus": { "chromosome": "23", "start_pos": 11546127, "end_pos": 11610700, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005888", "url": "https://www.ensembl.org/id/ENSBTAG00000005888" } ] } } ], "crossref": [ { "id": "F1MHX8", "url": "https://alphafold.ebi.ac.uk/entry/F1MHX8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005888", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005888", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06263", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06263", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "536481", "url": "https://www.ncbi.nlm.nih.gov/gene/536481", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000998", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000998", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536481", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536481", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NSWQQAH", "url": "https://omabrowser.org/oma/group/NSWQQAH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MHX8", "url": "https://www.orthodb.org/?gene=F1MHX8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45080", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45080", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45080:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45080:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00629", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00629", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179811", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MHX8", "url": "https://www.uniprot.org/uniprotkb/F1MHX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MHX8-1", "url": "https://www.uniprot.org/uniprotkb/F1MHX8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVTCLLLLALIPFHCRGQGVYAPAQAQIMHAGQACVVKEDNISERVYTIREGDTLVLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPVLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYSCQVSVRNVCGIPDKAVSFQLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCVASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRQREAQVQLNVQFPPEVEPGSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPAVPVAAEAPDHSELRLDAVTRESSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSVRQLNQHNALVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPISSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRSKGALDTHAWSLSGNKGNVWQQAHVPINPSGPFQIIFEGVRGSGYLGDIAIDDVTLKKGECPRKQMDPNKVVVMPGSGAPRQPLPQLWGPVATFLLALQR", "length": 955, "header": "tr|F1MHX8-1|F1MHX8_BOVIN Isoform 1 of MAM domain-containing glycosylphosphatidylinositol anchor protein 1 OS=Bos taurus OX=9913 GN=MDGA1 PE=4 SV=2 CANONICAL=F1MHX8-1" }, "isoforms": [ { "isoform_ac": "F1MHX8-1", "url": "https://www.uniprot.org/uniprotkb/F1MHX8/entry", "sequence": { "sequence": "MEVTCLLLLALIPFHCRGQGVYAPAQAQIMHAGQACVVKEDNISERVYTIREGDTLVLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPVLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYSCQVSVRNVCGIPDKAVSFQLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCVASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRQREAQVQLNVQFPPEVEPGSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPAVPVAAEAPDHSELRLDAVTRESSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSVRQLNQHNALVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPISSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRSKGALDTHAWSLSGNKGNVWQQAHVPINPSGPFQIIFEGVRGSGYLGDIAIDDVTLKKGECPRKQMDPNKVVVMPGSGAPRQPLPQLWGPVATFLLALQR", "length": 955, "header": "tr|F1MHX8-1|F1MHX8_BOVIN Isoform 1 of MAM domain-containing glycosylphosphatidylinositol anchor protein 1 OS=Bos taurus OX=9913 GN=MDGA1 PE=4 SV=2 CANONICAL=F1MHX8-1" }, "locus": { "chromosome": "23", "start_pos": 11610381, "end_pos": 11546395, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047505.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047505.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044710.3", "url": "https://www.ensembl.org/id/ENSBTAP00000044710.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:536481", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536481", "resource": "KEGG Pathway" }, { "id": "R-BTA-163125", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "resource": "Reactome", "description": "Post-translational modification: synthesis of GPI-anchored proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZBT9-1", "protein_name": "MAM domain containing glycosylphosphatidylinositol anchor 1", "gene_name": "MDGA1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRPPLRRHLASPRPERDGFTEPPDQLGVARTIVQPRGDIGLRRGWNSERNKFRRHLQTLEAPAQAQIIHAGQACVVKEDNISERVYTIREGDTLVLQCLVTGHPRPQVRWTKTAGSASDKFQETSVLNETLRIEKIQRLQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPVLTVHQTISDVRGSFYQEKTVFLRCTVNSNPPARFIWKRGAETLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCSIPDKSITFQLTNTTAPPALKLSVNETLVVNPGDNVTMQCSLTGGDPQPEVLWSHSPGPLPPNSLVQGGNLTIWRIRVEDSGYYNCTAINNVGNPAKKTVNLLVRSMKNATFQITPDVIKESETIQLGQDLKLSCHVDAVPQEKVVYSWYKNGKPARFSDRLLITRNDPELPPVTCSLEIIDLRFSDYGTYLCVATFQGAPIPDLSVEVNISSETVPPTISVPKGQSTITVREGSRAELQCEVRGKPKPPIIWSRVDKETPMPSGTMTVETYDGKLRLESVSRDMSGTYKCQTARYNGFNIRPREALVQLNVQFPPVVEPAFQDVRQGMGRSVTLRCTMLKGSPMKVATSVWRFNGTLLAQPPAEQQDYSELKVDSVSRETSGSYECSISNDVGVSACLFQVSAKAYSPEFYYDTPNPTLSQKQSKNYSYILQWTQKEPDAVDPILKYRLEVRQLAQRNTIQTFIPVQKMEKGLLLEHILPNLKVPQSYEVRLTPITSFGAGDMAARIIRYMEPINYPSPTDNTCRFEDEKICGFVQDKMDNFDWTRQNALTQNPKRTVNTGPPTDISGTPEGYYMFIEASRPRVTGDKARLISPLYNITAKYYCVSFYYHMYGKHIGSLNLLVRVRNKRAIDTQVWSLSGNRGNMWQQAHVPINPPGPFQIIFEGVRGTSYEGDIAIDDVTLKKGDCPRKPIGPNKAVALPGSGVSAQHGPCLCGPLTFFLYVLLR", "length": 987 }, "evidence": [ { "id": "F1MHX8", "url": "https://omabrowser.org/oma/group/F1MHX8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RVR8-1", "protein_name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1", "gene_name": "MDGA1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEVTCLLLLALIPFHCRAQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLVLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPVLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAVTFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCVASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETSDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPGSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPAIPIAAEAPDHSELRLDAVTRDSSGSYECSVSNDVGSAVCLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSVRQLNQHNAMVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPINPSGPFQIIFEGVRGSGYLGDIAIDDVTLKKGECPRKQMDPNKVVVMPGSGAPCQPRPQLWGSMAIFLLVWQR", "length": 955 }, "evidence": [ { "id": "F1MHX8", "url": "https://omabrowser.org/oma/group/F1MHX8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P85171-1", "protein_name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1", "gene_name": "Mdga1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIRESDTLVLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPVLTVHQTVSDVRGNFYQEKTVFLRCTVSSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKSITFQLTNTTAPPTLKLSVNETLVVNPGENVTVQCLLTGGDPLPQLHWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSLKNATFQITPDMIKESENIQLGQDLKLSCHVDAVPQEKVNYQWFKNGKPARTSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCVASFPGSPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLALEETPDGKLRVERVSREMSGTYRCQTARYNGFNVRAREAQVQLTVHFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVLPAAAAEGPDHAELRLDALTRDSSGNYECSVSNDVGSATCLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAMVKAIPVRRVEKGQLLEYTLTDLRVPHSYEIHLTPYTTFGAGDMASRVIHYTEPINSPSLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGTLDTHAWSLSGNKGNVWQQAHVPINPSGPFQIIFEGVRGSGYLGDIAIDDVTLKKGECPRRQMDPNKVVVMPGSGAPRLSSLQLWGSMTIFLLALQR", "length": 956 }, "evidence": [ { "id": "F1MHX8", "url": "https://omabrowser.org/oma/group/F1MHX8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q0PMG2-1", "protein_name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1", "gene_name": "Mdga1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIRESDTLVLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPVLTVHQTVSDVRGNFYQEKTVFLRCTVSSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFQLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLHWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSLKNATFQITPDMIKESENIQLGQDLKLSCHVDAVPQEKVNYQWFKNGKPARTSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGSPVPDLSIEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLALEETPDGKLRLESVSRDMSGTYRCQTARYNGFNVRPREAQVQLTVHFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVLPAAAVETPDHAELRLDALTRDSSGNYECSVSNDVGSATCLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAMVKAIPVRRVEKGQLLEYILTDLRVPHSYEIRLTPYTTFGAGDMASRIIHYTEPINLPSLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGTLDTHAWSLSGNKGNVWQQAHVPINPSGPFQIIFEGVRGSGYLGDIAIDDVTLKKGECPRRQMDPNKVVVMPGSGAPRLSSLQLWGSMAIFLLALQR", "length": 956 }, "evidence": [ { "id": "F1MHX8", "url": "https://omabrowser.org/oma/group/F1MHX8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NFP4-1", "protein_name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1", "gene_name": "MDGA1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNISERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQR", "length": 955 }, "evidence": [ { "id": "F1MHX8", "url": "https://omabrowser.org/oma/group/F1MHX8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "GABA-ergic synapse", "id": "GO:0098982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982", "evidence": [ { "database": "UniProtKB", "id": "F1MHX8", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1MHX8", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MHX8", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "F1MHX8", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "F1MHX8", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "F1MHX8", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" } ], "pmid": "" }, { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "F1MHX8", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "F1MHX8", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" } ], "pmid": "" }, { "name": "neuron migration", "id": "GO:0001764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "evidence": [ { "database": "UniProtKB", "id": "F1MHX8", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" } ], "pmid": "" }, { "name": "regulation of synaptic membrane adhesion", "id": "GO:0099179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099179", "evidence": [ { "database": "UniProtKB", "id": "F1MHX8", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" } ], "pmid": "" }, { "name": "regulation of presynapse assembly", "id": "GO:1905606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905606", "evidence": [ { "database": "UniProtKB", "id": "F1MHX8", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 432, "end_pos": 434, "annotation": "n_glycosylation_sequon" }, { "start_pos": 655, "end_pos": 657, "annotation": "n_glycosylation_sequon" }, { "start_pos": 747, "end_pos": 749, "annotation": "n_glycosylation_sequon" }, { "start_pos": 826, "end_pos": 828, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MHX8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 955, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MHX8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MHX8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MHX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" }, { "id": "PS50853", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50853" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibronectin type-III", "eco_id": "ECO_0000259", "start_pos": 643, "end_pos": 743, "start_aa": "Thr", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MHX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 24, "end_pos": 123, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MHX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHX8" }, { "id": "PS50060", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50060" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MAM", "eco_id": "ECO_0000259", "start_pos": 751, "end_pos": 918, "start_aa": "Asn", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 235, "end_pos": 237 }, { "start_pos": 247, "end_pos": 249 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 307, "end_pos": 309 }, { "start_pos": 331, "end_pos": 333 }, { "start_pos": 42, "end_pos": 44 }, { "start_pos": 432, "end_pos": 434 }, { "start_pos": 655, "end_pos": 657 }, { "start_pos": 747, "end_pos": 749 }, { "start_pos": 826, "end_pos": 828 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MHY8-1", "uniprot_ac": "F1MHY8", "uniprot_id": "F1MHY8_BOVIN", "mass": { "chemical_mass": 24894.0, "monoisotopic_mass": 24894.0 }, "refseq": {}, "gene_names": [ { "name": "TNFRSF18", "type": "recommended", "evidence": [ { "id": "F1MHY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHY8" } ] } ], "protein_names": [ { "name": "TNF receptor superfamily member 18", "type": "synonym", "evidence": [ { "id": "F1MHY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MHY8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MHY8", "url": "https://www.uniprot.org/uniprotkb/F1MHY8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TNFRSF18", "url": "https://www.uniprot.org/uniprotkb/F1MHY8", "locus": { "chromosome": "16", "start_pos": 51296582, "end_pos": 51293199, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015632", "url": "https://www.ensembl.org/id/ENSBTAG00000015632" } ] } } ], "crossref": [ { "id": "F1MHY8", "url": "https://alphafold.ebi.ac.uk/entry/F1MHY8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015632", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015632", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13417", "url": 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"http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11559", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00135", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00135", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-211945", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-211945", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8964038", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964038", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MI11", "url": "https://www.uniprot.org/uniprotkb/F1MI11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI11-1", "url": "https://www.uniprot.org/uniprotkb/F1MI11-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "VRSMGTVVRTGSRALVGVACLLLAFSATDTGPGVTQPEVDTPLGRVRGRQVGVKGTDHLVNVFLGIPFAQPPLGPHRFSAPRPAESWEGVRDASRAHAVCPQDPERMNNSRFTLDGKHQTFPISEDCLILNIYSPAEAPSGAGRPVMVWFHGGSLVTGTATSHDGSALAAYGDVVVVTVQYRLGFLGFFSTGDKHAPGNWGFLDVVAALRWVQGNITPFGGDFNSVTIFGESSGASVVSALVLSPLAAGLFHRAIAQSGIITVPGLLDPNPWLLAQTLADSLACNSDSSAEMVQCLRQKTIKEMILAYKSKKIASYNIDGTFFPKSAEELLRERQFPSVPFLFGFNNHEFGWLIPRGWGFLDKMDQLSLEDMLAILRPSLTNMDVPTEVMPTIIKEYLGSSSDGQAKREALQELLSDIIITLPMLQFARDLQDSGVSIFFYEFQHRPSSFAKIKPAWVQADHGAELTFMFGGPFLTDESSMLAFPEATEEEKQLSLTMMAQWTNFAWTGDPNGKGLPLWPPFNHAEEYLEISLVPRVNQKPREARMQLWAEILPTKFGQWQQKQKGKKVQEEL", "length": 573, "header": "tr|F1MI11-1|F1MI11_BOVIN Isoform 1 of Carboxylic ester hydrolase OS=Bos taurus OX=9913 GN=CES3 PE=1 SV=2 CANONICAL=F1MI11-1" }, "isoforms": [ { "isoform_ac": "F1MI11-1", "url": "https://www.uniprot.org/uniprotkb/F1MI11/entry", "sequence": { "sequence": "VRSMGTVVRTGSRALVGVACLLLAFSATDTGPGVTQPEVDTPLGRVRGRQVGVKGTDHLVNVFLGIPFAQPPLGPHRFSAPRPAESWEGVRDASRAHAVCPQDPERMNNSRFTLDGKHQTFPISEDCLILNIYSPAEAPSGAGRPVMVWFHGGSLVTGTATSHDGSALAAYGDVVVVTVQYRLGFLGFFSTGDKHAPGNWGFLDVVAALRWVQGNITPFGGDFNSVTIFGESSGASVVSALVLSPLAAGLFHRAIAQSGIITVPGLLDPNPWLLAQTLADSLACNSDSSAEMVQCLRQKTIKEMILAYKSKKIASYNIDGTFFPKSAEELLRERQFPSVPFLFGFNNHEFGWLIPRGWGFLDKMDQLSLEDMLAILRPSLTNMDVPTEVMPTIIKEYLGSSSDGQAKREALQELLSDIIITLPMLQFARDLQDSGVSIFFYEFQHRPSSFAKIKPAWVQADHGAELTFMFGGPFLTDESSMLAFPEATEEEKQLSLTMMAQWTNFAWTGDPNGKGLPLWPPFNHAEEYLEISLVPRVNQKPREARMQLWAEILPTKFGQWQQKQKGKKVQEEL", "length": 573, "header": "tr|F1MI11-1|F1MI11_BOVIN Isoform 1 of Carboxylic ester hydrolase OS=Bos taurus OX=9913 GN=CES3 PE=1 SV=2 CANONICAL=F1MI11-1" }, "locus": { "chromosome": "18", "start_pos": 34668018, "end_pos": 34655283, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056670.4", "url": "https://www.ensembl.org/id/ENSBTAT00000056670.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049320.2", "url": "https://www.ensembl.org/id/ENSBTAP00000049320.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-211945", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-211945", "resource": "Reactome", "description": "Phase I - Functionalization of compounds" }, { "id": "R-BTA-8964038", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8964038", "resource": "Reactome", "description": "LDL clearance" } ], "orthologs": [ { "uniprot_canonical_ac": "Q63880-1", "protein_name": "Carboxylesterase 3A", "gene_name": "Ces3a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTNMETTAQAGSSVRVWMACLLLIFPTTVIGPKVTQPEVDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQDVERMSNSRFTLNEKMKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSSTSHDGSALAAYGDVVVVTVQYRLGIFGFLSTGDKHMPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVISKILEDLNAWSEAQNFANSVACGSASPAELVQCLLQKEGKDLITKKNVNISYTVNDSFFPQRPQKLLANKQFPTVPYLLGVTNHEFGWLLLKFWNILDKMEHLSQEDLLENSRPLLAHMQLPPEIMPTVIDEYLDNGSDESATRYALQELLGDITLVIPTLIFSKYLQDAGCPVFLYEFQHTPSSFAKFKPAWVKADHSSENAFVFGGPFLTDESSLLAFPEATEEEKQLSLTMMAQWSQFARTGNPNGKGLPPWPQLNQLEQYLEIGLEPRTGVKLKKGRLQFWTETLPRKIQEWHREQRSRKVPEEL", "length": 571 }, "evidence": [ { "id": "F1MI11", "url": "https://omabrowser.org/oma/group/F1MI11/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6UWW8-1", "protein_name": "Carboxylesterase 3", "gene_name": "CES3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEMVQCLQQKEGEELVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCQAFQEFMGDVFINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPWPQFNQAEQYLEINPVPRAGQKFREAWMQFWSETLPSKIQQWHQKQKNRKAQEDL", "length": 571 }, "evidence": [ { "id": "F1MI11", "url": "https://omabrowser.org/oma/group/F1MI11/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carboxylesterase activity", "id": "GO:0106435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106435", "evidence": [ { "database": "UniProtKB", "id": "F1MI11", "url": "https://www.uniprot.org/uniprotkb/F1MI11" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 215, "end_pos": 217, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, lipid droplet, transport vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MI11-1" ], "evidence": [ { "id": "R-BTA-8937442", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8937442" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MI11", "gene_name": "CES3", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "F1MI11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI11" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MI11-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 573, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MI11-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MI11" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MI11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI11" }, { "id": "PF00135", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00135" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Carboxylesterase type B", "eco_id": "ECO_0000259", "start_pos": 36, "end_pos": 549, "start_aa": "Gln", "end_aa": "Trp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 108, "end_pos": 110 }, { "start_pos": 215, "end_pos": 217 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MI29-1", "uniprot_ac": "F1MI29", "uniprot_id": "F1MI29_BOVIN", "mass": { "chemical_mass": 128904.0, "monoisotopic_mass": 128904.0 }, "refseq": { "ac": "XP_002698126", "name": "exportin-6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698126" }, "gene_names": [ { "name": "XPO6", "type": "recommended", "evidence": [ { "id": "F1MI29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI29" } ] }, { "name": "XPO6", "type": "synonym", "evidence": [ { "id": "XP_002698126", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698126" } ] } ], "protein_names": [ { "name": "Exportin-6", "type": "recommended", "evidence": [ { "id": "F1MI29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI29/entry#names_and_taxonomy" } ] }, { "name": "Ran-binding protein 20", "type": "synonym", "evidence": [ { "id": "F1MI29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI29/entry#names_and_taxonomy" } ] }, { "name": "exportin-6 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002698126", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698126" } ] } ], "function": [ { "annotation": "Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.", "evidence": [ { "database": "UniProtKB", "id": "F1MI29", "url": "https://www.uniprot.org/uniprotkb/F1MI29#function" }, { "database": "UniProtKB", "id": "ARBA00059315", "url": "https://www.uniprot.org/uniprotkb/ARBA00059315#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MI29", "url": "https://www.uniprot.org/uniprotkb/F1MI29" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "XPO6", "url": "https://www.uniprot.org/uniprotkb/F1MI29", "locus": { 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"https://www.ebi.ac.uk/interpro/entry/IPR013598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040016", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040016", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510797", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510797", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KITRFNH", "url": "https://omabrowser.org/oma/group/KITRFNH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MI29", "url": "https://www.orthodb.org/?gene=F1MI29", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21452", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21452", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21452:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21452:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03810", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03810", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08389", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08389", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26714", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002698126", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698126", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MI29", "url": "https://www.uniprot.org/uniprotkb/F1MI29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI29-1", "url": "https://www.uniprot.org/uniprotkb/F1MI29-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTLPYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACPREDLSVARKEELRKLLLDQVQTVLGLLTGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLNQPIPILDAESEYICSLALECLAHLFSWIPLSASITPSLLTTIFHFARFGCDIRARKMASVNGSSQNCVLGQERGRLGVLAMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDNNAHTVKSRLEELDESYIEKFTDFLRLFVSVHLRRIESYSQFPVVEFLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYLTSKIKSRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFIVTSGSGPRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFTGDVFAARFSDALTVVERLVKVTLYGSQIKLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHWLAQYCSEAHRQNTQQFVSLISTTMDAITPLITTKVQDKLLLSACHLLVSLATTVRPVFLISIPAVQKVFNRITDASAQRLVDKAQVLVCRALSNILLLPWPNLPENEQQWPVRSMNHASLISALSRDYRNLKPNAVTPQRKMPLDDTKVIIHQTLSVLEDIVENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTLFRGLRVQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSIIALCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTILASVQRGMAEEQMENQPQFSAIMQAFGQSFLQPDIHLFKQNLFYLETLNTKQKLYHKKIFRSAMLFQFVNVLLQVLVCRSHDLLQEDIGIAIYNMASVDFDGFFTAFLPEFLTSCDGVDANQKNVLGRNFKMDRDLPSFTQNVHRLVNDLRYYRLCNDSLPPGTVKL", "length": 1125, "header": "tr|F1MI29-1|F1MI29_BOVIN Isoform 1 of Exportin-6 OS=Bos taurus OX=9913 GN=XPO6 PE=3 SV=2 CANONICAL=F1MI29-1" }, "isoforms": [ { "isoform_ac": "F1MI29-1", "url": "https://www.uniprot.org/uniprotkb/F1MI29/entry", "sequence": { "sequence": "MASEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTLPYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACPREDLSVARKEELRKLLLDQVQTVLGLLTGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLNQPIPILDAESEYICSLALECLAHLFSWIPLSASITPSLLTTIFHFARFGCDIRARKMASVNGSSQNCVLGQERGRLGVLAMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDNNAHTVKSRLEELDESYIEKFTDFLRLFVSVHLRRIESYSQFPVVEFLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYLTSKIKSRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFIVTSGSGPRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFTGDVFAARFSDALTVVERLVKVTLYGSQIKLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHWLAQYCSEAHRQNTQQFVSLISTTMDAITPLITTKVQDKLLLSACHLLVSLATTVRPVFLISIPAVQKVFNRITDASAQRLVDKAQVLVCRALSNILLLPWPNLPENEQQWPVRSMNHASLISALSRDYRNLKPNAVTPQRKMPLDDTKVIIHQTLSVLEDIVENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTLFRGLRVQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSIIALCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTILASVQRGMAEEQMENQPQFSAIMQAFGQSFLQPDIHLFKQNLFYLETLNTKQKLYHKKIFRSAMLFQFVNVLLQVLVCRSHDLLQEDIGIAIYNMASVDFDGFFTAFLPEFLTSCDGVDANQKNVLGRNFKMDRDLPSFTQNVHRLVNDLRYYRLCNDSLPPGTVKL", "length": 1125, "header": "tr|F1MI29-1|F1MI29_BOVIN Isoform 1 of Exportin-6 OS=Bos taurus OX=9913 GN=XPO6 PE=3 SV=2 CANONICAL=F1MI29-1" }, "locus": { "chromosome": "25", "start_pos": 25727047, "end_pos": 25621175, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013621.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013621.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013621.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013621.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 210, "start_aa": "Thr", "end_pos": 210, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr210", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 771, "start_aa": "Thr", "end_pos": 771, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr771", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510797", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510797", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z5T8-1", "protein_name": "Exportin 6", "gene_name": "XPO6", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAVPWSDSKERGSRCSQQPMICAVRAEASEEASLRALESLMTEFFHNCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAQHKTLPYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACPREDLSVARKEELRKLLLDQVQTVLGLLTGILESIWDKHSVTAATPPPSPTSGESGDLLSSLLQSPSAAKLLNQPIPILDTDSEYICSLALECLAHLFSWIPLSTSITPSLLTTIFHFARFGCDTRVRKMSSVNGSSQNVGLGAERGRLGVLAMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKENNAHTVKSRLEELDESYIEKFTDFLRLFVSVHLRRIESYSQFPVVEFLALLFKYTFHQPTHEGYFSCLDIWTLFLDYLTSKIKSRLADKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFVVTSGTGHRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDMFAARFNDALTVVERLVKVTLYGSQIKLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHWLAQFYSEVHRQNPEQFISLVSTALEAITPLISSKVQEKLLLSACHLLVSLATTVRPVFLISIPAVQKVFNRITDTSAQRLPDKAQVLVCRALSNVLLLPWPNLPESEQQWAVRSTNHTSLISALTRDYRQLKSNAILPQRKVQLEDTKVIIHQTLSVLEDIVESISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTLFQGLRVQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSVISLCMEQVYPIIAERSSPDVKAELFELLFRVLHHNWRYFFKSSVLASVQRGVAEEQMENEAQFSAIMQAFGQSFLQPDIHLFKQNLFYLETLNTKQKLYHKKIFRTTMLFQFVNVLLQVLVHKSHDLLQEEIGIATYNMASVDFDGFYSAFLPEFLASCDGVDSNQKNVLGRNFKMDRDLPSFTQNVHRLVNDLRYYRLCNDSLPPGTVKL", "length": 1151 }, "evidence": [ { "id": "F1MI29", "url": "https://omabrowser.org/oma/group/F1MI29/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RFG5-1", "protein_name": "Exportin-6", "gene_name": "XPO6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MASEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTLPYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACPREDLSVARKEELRKLLLDQVQTVLGLLTGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLNQPIPILDVESEYICSLALECLAHLFSWIPLSASITPSLLTTIFHFARFGCDIRARKMASVNGSSQNCVLGQERGRLGVLAMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDNNAHTVKSRLEELDESYIEKFTDFLRLFVSVHLRRIESYSQFPVVEFLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYLTSKIKSRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFIVTSGSGHRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDVFAARFSDALTVVERLVKVTLYGSQIKLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHWLAQYCSEAHRQNTQQFVSLISTTMDAVTPLISTKVQDKLLLSACHLLVSLATTVRPVFLISIPAVQKVFSRITDASAQRLVDKAQVLVCRALSNILLLPWPNLPENEQQWPVRSINHASLISALSRDYRNLKPNAVAPQRKMPLDDTKVIIHQTLSVLEDIVENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTLFRGLRVQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSIISLCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTVLASVQRGIAEEQMENEPQFSAIMQAFGQSFLQPDIHLFKQNLFYLETLNTKQKLYHKKIFRTAMLFQFVNVLLQVLVHKSHDLLQEEIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDANQKNVLGRNFKMDRDLPSFTQNVHRLVNDLRYYRLCNDSLPPGTVKL", "length": 1125 }, "evidence": [ { "id": "F1MI29", "url": "https://omabrowser.org/oma/group/F1MI29/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3V858-1", "protein_name": "Exportin-6", "gene_name": "Xpo6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASEDASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQVGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTLPYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACPREDLSVARKEELRKLLLDQVQTVLGLLTGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLHQPIPILDVESEYVCSLALECLAHLFSWIPLSASITPSLLTTIFHFARFGCDTRARKMASVNGSSQNCVLGQERGRLGVLAMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDNNAHTVKSRLEELDESYVEKFTDFLRLFVSVHLRRIESYSQFPVLEFLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYLTSKIKSRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFVVTSGSGHRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFTGDVFAARFSDALTVVERLVKVTLYGSQIKLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHWLAQYCSEAHRQNTQQFVTLISTTMDAITPLISTKVQDKLLLSACHLLVSLATTVRPVFLISIPAMQKVFNSIIDASAQRLTDKAQVLVCRALSNTLLLPWPNLPESEQQWPLRSINHASLISALSRDYHSLKPSAAAPQRKMPLDDTKVIIHQTLSVFEDIVENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTLFRGLRVQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSIIALCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTVLASVQRGIAEEQMENEPQFSAIMQAFGQSFLQPDIHLFKQNLFYLETLNTKQKLYHKKIFRTTMLFQFVNVLLQVLVHKSHDLLQEEIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDANQKNVLGRNFKMDRDLPSFTQNVHRLVNDLRYYRLCNDSLPPGTVKL", "length": 1125 }, "evidence": [ { "id": "F1MI29", "url": "https://omabrowser.org/oma/group/F1MI29/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q54CB2-1", "protein_name": "Exportin-6", "gene_name": "xpo6", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNNNDMDQKAKELQNVLEQFYLTTDNPKRKEIDTILNNYKAQSDSYEHVQYYLVHSDNQYVIWFSLSVIEDKVNKAWNSISASSQTQTKGLLLDIYLNKTGANSNSTVKNVLPQFIISKLGQVIADIGRYEFESNPQSYLLNITSIVRNPSTSIRGINLLQCISDSFTTNKKVISQQKKTTLKKLLHQNSPIIIQVLVDCLGQLFDQNAEKKFKHANLLAFHVGSPDTNTYTASFNAESKNLTKAVFDALLSYFTWVPLSDLLVPSLFDILFKYLRLDKNSIPALECLNEIVSKNLVPKGFESFLMRIFHQVYSLLTDIVSNGGQQINQYHPEFLNKFTQFIQIFINNHLGRIETNPNFPIPDFLGLLFQYSFFQTQPESFLQCIDIWSTFLDYLINLSQENGTPPPSKYTDGLLLFQSELVKRILYIFNNNTLSELDDEDKEINENGISETQLESYIKKSIEVVAKVTELYPEKSLENLYPLFTQNVTSFFCKAEESIKQGVSMENEQQFQYLVKDVTTILHLFGRLADQFVVSFAQTFTAANFIFQKLLDMCLFSVNQYIYKFGSDWEKLQIELLCTIRSFCFWLAEYGNQVRAIVGQQPDFDSNITKLISIIVPLFERNAPESILSSAGKLLMSLATISKPLNLFTQMDMLISNIHNICAPLSPSIQSILYPAISCTILLPPSNVNLSQQWDQRRPKYSPFIKGITASFLEIPQIPNFVEGKIFCKEELIQRVLRVLKVVTAIIRTVPEVTQAKSILHDGIQDTLKVTLGLFRVYISYPIVLEAILDFFFVLFEFLKAQVGVVFTQQTISTFLDILGGDNLNQLLSSGNDTGISIIKKLIEILTFIVQQPGNSFESLLGSTIEFSMEKLYPMIANTSSVLRSPFFTLLYSILDNHWKQCQQIQINSILTSFQSIFKQNDVNLFKQNLDHFEKLNSKLKLYEKISSMEPVFGCSFISMFFDVLISDTQSVHTDDIIVTIYRFASLNFDKFFNEFFTTFLVQKNQLSNEQKQILRSNFSNAIDQPTFSTNMTQFINDFSYFSFINS", "length": 1047 }, "evidence": [ { "id": "F1MI29", "url": "https://omabrowser.org/oma/group/F1MI29/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q924Z6-1", "protein_name": "Exportin-6", "gene_name": "Xpo6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQVGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTLPYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACPREDLSVARKEELRKLLLDQVQTVLGLLTGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLHQPIPILDVESEYVCSLALECLAHLFSWIPLSASITPSLLTTIFHFARFGCDTRARKMASVNGSSQNCVLGQERGRLGVLAMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDNNAHTVKSRLEELDESYIEKFTDFLRLFVSVHLRRIESYSQFPVVEFLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYLTSKIKSRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFVVTSGSGHRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDVFAARFNDALTVVERLVKVTLYGSQIKLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHWLAQYCGEAHRQNTQQFVTLISTTMDAITPLISTKVQDKLLLSACHLLVSLATTVRPVFLISIPAVQKVFNSIIDASAQRLTDKAQVLVCRALSNTLLLPWPNLPESEQQWPLRSINHASLISALSRDYHSLKPSATAPQRKVPLGDTKVIIHQTLSVLEDIVENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTLFRGLRVQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSIIALCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTVLASVQRGIAEEQMENEPQFSAIMQAFGQSFLQPDIHLFKQNLFYLETLNTKQKLYHKKIFRTTMLFQFVNVLLQVLVHKSHDLLQEEIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDANQKNVLGRNFKMDRDLPSFTQNVHRLVNDLRYYRLCNDSLPPGTVKL", "length": 1125 }, "evidence": [ { "id": "F1MI29", "url": "https://omabrowser.org/oma/group/F1MI29/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96QU8-1", "protein_name": "Exportin-6", "gene_name": "XPO6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTLPYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACPREDLSVARKEELRKLLLDQVQTVLGLLTGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLNQPIPILDVESEYICSLALECLAHLFSWIPLSASITPSLLTTIFHFARFGCDIRARKMASVNGSSQNCVSGQERGRLGVLAMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDNNAHTVKSRLEELDESYIEKFTDFLRLFVSVHLRRIESYSQFPVVEFLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYLTSKIKSRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFIVTSGSGHRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDVFAARFNDALTVVERLVKVTLYGSQIKLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHWLAQYCSEVHRQNTQQFVTLISTTMDAITPLISTKVQDKLLLSACHLLVSLATTVRPVFLISIPAVQKVFNRITDASALRLVDKAQVLVCRALSNILLLPWPNLPENEQQWPVRSINHASLISALSRDYRNLKPSAVAPQRKMPLDDTKLIIHQTLSVLEDIVENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTLFRGLRVQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSIIALCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTVLASVQRGIAEEQMENEPQFSAIMQAFGQSFLQPDIHLFKQNLFYLETLNTKQKLYHKKIFRTAMLFQFVNVLLQVLVHKSHDLLQEEIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDANQKSVLGRNFKMDRDLPSFTQNVHRLVNDLRYYRLCNDSLPPGTVKL", "length": 1125 }, "evidence": [ { "id": "F1MI29", "url": "https://omabrowser.org/oma/group/F1MI29/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "X2J9Y4-1", "protein_name": "Ellipsoid body open, isoform C", "gene_name": "ebo", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MHAASLTTVEGLLQEFYQPSTSNARKREIETNLLAFKSQPEAWQLCLRVATSSDTTENQFLWFFSTSTLEHTITRRWTQLTSTDKTLLRETLWNSYAQLVATPNVAKRHRDTLAQLIALLGKREFPEQDPNYMQHCMELTKTRFQLGINLLKITSEEVVSNRGDLTTEWKQYFYSCISMCVPDVLDLVTKYLLIAVCHINGKDIQTTIPNTLMDFSLTSALPNDNQLSSSILDLLGCVQHLVSWIRTELISEYFLMSILDLSQWRPAHEPISLAALSVLNELLYLQKPLPFPGPLMGGVTSLLEQHNNNRRQSEMYSDKFRELLRLYTTKYAAKLMQEPDLLETFLNLLYSCTTELHGALDFTEKLEIWTPIIKGIAQHPAKITRYNNVLTQLVDEIMRRTQFEANKPELEVLDNELMEDDTSATEWQQFLDQCFESLALLANTRGAHIVFAQVYNHWSRPQMYLLSLEHALDHGSARSYEAARKLKGANVGEILRDFATVCQAVVRLAPLMDSSTAAPGVADEMECQLQMLSDSLLQTLQLLASNRLYSGGSEMDKATFQTDLDNLYAQVLLAMRSIFPLTKAMSGEELLHRLFAILGSIFACNGSLTAASPIVQQAASELLLFISTVIRPKCLLDIPQIQSLLQAGSRLGAQLPRQVCINVHISLVSYMVLPWKSVPEQQQEYPRRLWMLREYVQGLAQNFLDLDLGQANESKVAATTLSLLGTFTALIEYFKATGGNAKDMLASTFKPILTKALMIFNNFGQSSIAMAITVAEFSLSMLRTLPTHLGAQFIKEMITLFISVSSREQLTLSRLAVMEKILQMFKLIVEQPGSASLGLLPSILDFSTQQILPLLQQQNAATDNSEITSLLYALFDSVLTCKWQFFYKNQLSNGHSGGGSGNFNCSDNLHPAHFMAILNAYGQMLVSGTDPSNVRSVLFSMQNVNERSRLYQRALFKEQLLASFQRALLNLLLSGEGSLHFDMIAQALYAMGQVDRRQLLESFVHASLPVAQTSLEEICQTNVLPFIVQDIPTFTQKLTQLMQDAHCVHLNETA", "length": 1054 }, "evidence": [ { "id": "F1MI29", "url": "https://omabrowser.org/oma/group/F1MI29/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MI29", "url": "https://www.uniprot.org/uniprotkb/F1MI29" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1MI29", "url": "https://www.uniprot.org/uniprotkb/F1MI29" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MI29", "url": "https://www.uniprot.org/uniprotkb/F1MI29" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "F1MI29", "url": "https://www.uniprot.org/uniprotkb/F1MI29" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "F1MI29", "url": "https://www.uniprot.org/uniprotkb/F1MI29" } ], "pmid": "" }, { "name": "nuclear export signal receptor activity", "id": "GO:0005049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005049", "evidence": [ { "database": "UniProtKB", "id": "F1MI29", "url": "https://www.uniprot.org/uniprotkb/F1MI29" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein export from nucleus", "id": "GO:0006611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006611", "evidence": [ { "database": "UniProtKB", "id": "F1MI29", "url": "https://www.uniprot.org/uniprotkb/F1MI29" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1115, "end_pos": 1117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 293, "end_pos": 295, "annotation": "n_glycosylation_sequon" }, { "start_pos": 540, "end_pos": 542, "annotation": "n_glycosylation_sequon" }, { "start_pos": 798, "end_pos": 800, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MI29-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1125, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MI29-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MI29" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MI29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI29" }, { "id": "PS50166", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50166" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Importin N-terminal", "eco_id": "ECO_0000259", "start_pos": 31, "end_pos": 97, "start_aa": "Ile", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 210, 771 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1115, "end_pos": 1117 }, { "start_pos": 293, "end_pos": 295 }, { "start_pos": 540, "end_pos": 542 }, { "start_pos": 798, "end_pos": 800 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MI35-1", "uniprot_ac": "F1MI35", "uniprot_id": "F1MI35_BOVIN", "mass": { "chemical_mass": 86933.0, "monoisotopic_mass": 86933.0 }, "refseq": { "ac": "XP_002696881", "name": "HHIP-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696881" }, "gene_names": [ { "name": "HHIPL1", "type": "recommended", "evidence": [ { "id": "F1MI35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI35" } ] }, { "name": "HHIPL1", "type": "synonym", "evidence": [ { "id": "XP_002696881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696881" } ] } ], "protein_names": [ { "name": "Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D", "type": "recommended", "evidence": [ { "id": "F1MI35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI35/entry#names_and_taxonomy" } ] }, { "name": "HHIP-like protein 1", "type": "synonym", "evidence": [ { "id": "XP_002696881", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696881" } ] } ], "function": [ { "annotation": "Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.", "evidence": [ { "database": "UniProtKB", "id": "F1MI35", "url": "https://www.uniprot.org/uniprotkb/F1MI35#function" }, { "database": "UniProtKB", "id": "ARBA00058074", "url": "https://www.uniprot.org/uniprotkb/ARBA00058074#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MI35", "url": "https://www.uniprot.org/uniprotkb/F1MI35" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HHIPL1", "url": "https://www.uniprot.org/uniprotkb/F1MI35", "locus": { "chromosome": "21", "start_pos": 64662816, "end_pos": 64632051, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026913", "url": "https://www.ensembl.org/id/ENSBTAG00000026913" } ] } } ], "crossref": [ { "id": "F1MI35", "url": "https://alphafold.ebi.ac.uk/entry/F1MI35", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026913", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026913", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100299504", "url": "https://www.ncbi.nlm.nih.gov/gene/100299504", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011041", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011041", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011042", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011042", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100299504", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100299504", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YSVEVRY", "url": "https://omabrowser.org/oma/group/YSVEVRY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MI35", "url": "https://www.orthodb.org/?gene=F1MI35", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19328", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19328", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19328:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19328:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00530", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00530", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03024", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03024", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07995", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07995", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002696881", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696881", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MI35", "url": "https://www.uniprot.org/uniprotkb/F1MI35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI35-1", "url": "https://www.uniprot.org/uniprotkb/F1MI35-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGRRAGAGAGAGTLLALLVLRALGAAAHPQCLDFRPPFRPPQPLRFCSQYSAFGCCTPEQDAALARRFGAVAARVDAAMWAECAGYALDLLCQECSPYVAHLYDAEDPSTPLRTVPGLCEDYCLDMWQTCRGLFRHLSPDRELWALEGNRAKLCRSLSLDDTDYCFPRLLVNENLNSNLGRVVADAEGCLQLCLEEVANGLRNPVAMVHARDGTHRFFVAEQLGLVWVYLPDRSRLEKPFLNISRAVLTSPWEGDERGFLGLAFHPSFRHNGKLYVYYSVGVGFDEWIRISEFRVSEDDVNAVDHDSERIILEIEEPASNHNGGQLLFGDDGYLYIFTGDGGMAGDPFGKFGNAQNKSALLGKVLRIDVDRNERGPLYRIPPDNPFVGDPAARPEVYAFGVRNMWRCSFDRGDPATGAGRGRLFCGDVGQNKFEEVDLVERGRNYGWRAREGYQCYDRKLCANASLDDVLPIFAYPHKLGKSVTGGYVYRGCEYPNLNGLYVFGDFMSGRLMSLRENPETGQWRYSEICMGRGQTCAFPGLINNYYPHIISFGEDEAGELYFMSTGMPSATVAHGVVYKMIDPSRRAPPGKCQIQPSRVKVRSRLIHFVPKEKFIRRTESTPRPTKAPRRSRPTAAPPAPTPRPPRPTSRPGRRRGSGRRRGRLGTADPEPSNGAVRLVRPAGLSPGRGRVEVFAGGRWGTVCDDAWDTKAAAVVCRQLGFLYAARAAKRAEFGEGRTLPILLDDVRCTGSERNLLECAHAGLGSHNCGHQEDAGVVCSREDPDL", "length": 786, "header": "tr|F1MI35-1|F1MI35_BOVIN Isoform 1 of Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D OS=Bos taurus OX=9913 GN=HHIPL1 PE=3 SV=2 CANONICAL=F1MI35-1" }, "isoforms": [ { "isoform_ac": "F1MI35-1", "url": "https://www.uniprot.org/uniprotkb/F1MI35/entry", "sequence": { "sequence": "MAGRRAGAGAGAGTLLALLVLRALGAAAHPQCLDFRPPFRPPQPLRFCSQYSAFGCCTPEQDAALARRFGAVAARVDAAMWAECAGYALDLLCQECSPYVAHLYDAEDPSTPLRTVPGLCEDYCLDMWQTCRGLFRHLSPDRELWALEGNRAKLCRSLSLDDTDYCFPRLLVNENLNSNLGRVVADAEGCLQLCLEEVANGLRNPVAMVHARDGTHRFFVAEQLGLVWVYLPDRSRLEKPFLNISRAVLTSPWEGDERGFLGLAFHPSFRHNGKLYVYYSVGVGFDEWIRISEFRVSEDDVNAVDHDSERIILEIEEPASNHNGGQLLFGDDGYLYIFTGDGGMAGDPFGKFGNAQNKSALLGKVLRIDVDRNERGPLYRIPPDNPFVGDPAARPEVYAFGVRNMWRCSFDRGDPATGAGRGRLFCGDVGQNKFEEVDLVERGRNYGWRAREGYQCYDRKLCANASLDDVLPIFAYPHKLGKSVTGGYVYRGCEYPNLNGLYVFGDFMSGRLMSLRENPETGQWRYSEICMGRGQTCAFPGLINNYYPHIISFGEDEAGELYFMSTGMPSATVAHGVVYKMIDPSRRAPPGKCQIQPSRVKVRSRLIHFVPKEKFIRRTESTPRPTKAPRRSRPTAAPPAPTPRPPRPTSRPGRRRGSGRRRGRLGTADPEPSNGAVRLVRPAGLSPGRGRVEVFAGGRWGTVCDDAWDTKAAAVVCRQLGFLYAARAAKRAEFGEGRTLPILLDDVRCTGSERNLLECAHAGLGSHNCGHQEDAGVVCSREDPDL", "length": 786, "header": "tr|F1MI35-1|F1MI35_BOVIN Isoform 1 of Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D OS=Bos taurus OX=9913 GN=HHIPL1 PE=3 SV=2 CANONICAL=F1MI35-1" }, "locus": { "chromosome": "21", "start_pos": 64661812, "end_pos": 64632217, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013614.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013614.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013614.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013614.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 642, "start_aa": "Thr", "end_pos": 642, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr642", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:100299504", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100299504", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5NYI4-1", "protein_name": "Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D", "gene_name": "HHIPL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRALRGAALALLLAAALGPGPGRPHPQCLDFKPPFRPPRALAFCRRYGAFGCCDARRDRALLQRFYRLSAHLDGPTYAACAGHLQDLLCQECSPYAAHLYDAEDPSTPVRTIPGLCQDYCQQVWQKCRSIFHYLSTDQELIALENNMAKFCRYLSLEDTDYCFPHLLANENLNQNLGLVTADAEGCLQLCLMEVANGLRNPVAMVHANDGTHRFFIAEQVGLVWAYLPDRSRLEKPFLNISEAVLTSPWEGDERGFLGIVFHPKFKFTGKVYVYYSVEVRYEERIRISEFRISSGDMNTVDHGSERIILEIEEPASNHNGGELLFGDDGYLYIFTGDGGMAGDPFGTFGNAQNKSALLGKVLRIDVNNNDRGPVYRIPPDNPFVDDPQARPEVYAYGVRNMWRCSFDRGEPDTKEGKGRLFCGDVGQNKYEEIDIVEKGKNYGWRAREGFSCYDKKLCVNSSLDDVLPIYAYPHKMGKSVTGGYVYRGCESPNLNGLYIFGDFMSGRLMSLKEDRATGEWQYSEICMGTGQTCMFPGLINNYYQYIISFAEDEAGELYFMSTGVPSATAPHGVVYKVVDTSRRAPPGKCQVEPLPVKVKSKLVKFVPKEKLIVKTPTPRPRLKTTTEAPRRGWPDHATPHTSALDRVDQAPVNRSVMLVPATAPSPRPGKGERKGQRRKKKPRNGAVRLMDGGSRGRSWGRVEVYVDGEWGTVCDDGWSSAAAAVVCRQLGFPYVVRASKKAEFGEGTLLRILLDDVQCSGQEKTLLECAHAEVGTHNCSHEEDAGVVCSREEVADW", "length": 797 }, "evidence": [ { "id": "F1MI35", "url": "https://omabrowser.org/oma/group/F1MI35/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D4A9N1-1", "protein_name": "Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D", "gene_name": "Hhipl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARQRTVAGIGPGALLALRALLVAAHPQCLDFRPPFRPPQPLSFCAQYSAFGCCTAEQDAALARRFRALETRMDAGVWATCAGYALDLLCQECSPYAAHLYDAEDPATPLRTVPGLCEDYCLDMWQTCRGLFRHLSPDRELWALESNRAKLCRYLSLDDTDYCFPSLLVNENLNSNLGRVVADAKGCLQLCLEEVANGLRNPVAMVHAGDGSHRFFVAEQVGLVWTYLPDRSRLEKPFLNVSQAVLTSPWEGDERGFLGLAFHPRFPHPSKLYVYYSVGVGFREWIRISEFRISEDDENTVDHGSERIILEIEEPASNHNGGQLLFGDDGFLYIFTGDGGMAGDPFGKFGNAQNKSALLGKVLRIDVDRKERGLPYGIPLDNPFVDDPEARPEVYALGVRNMWRCSFDRGDPVSGTHRGRLFCGDVGQNKYEEVDLVERGRNYGWRAREGFECYDRKLCANASLDDVLPIFAYPHKLGKSVTGGYVYRGCEYPNLNGLYIFGDFMSGRLMSLRENPESGQWKYSEVCMGRGQTCAFPGLINNYYPYIISFAEDEAGELYFMSTGVPSATAARGVIYKVTDPSRRAPPGKCKIRPAQVKVKSHLIPFVPKEKFIRTSESTPRPTARAPTKAPRRRRPTAAPPAPTLRPTKPARPTRRPGARKGGGRRRGRPGTAVPEPQNGSVRLVRPSGLSPGRGRVEVFIGGRWGTVCDDGWDIKAAAVVCRQLGFAHAVRAAKRAEFGEGRALRILLDDVRCAGSERNLLECAHAGVGTHNCKHEEDAGVECSHEDPDL", "length": 791 }, "evidence": [ { "id": "F1MI35", "url": "https://omabrowser.org/oma/group/F1MI35/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F6PEI8-1", "protein_name": "Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D", "gene_name": "hhipl1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MWYFCDVFGRIWQPPFILFYLSAFWIAPAILHPQCLDFKPPFQPQQELQFCQMYKNFGCCDYARDQELMKKYYRVMDNFDYYGYSNCASYVQDLLCQECSPYAAHLFDAEDPSTPLRTIPGLCPDYCAQFHSKCRSFLTLLSDDPRLAELEHDQRKLCQYLELDDPDYCYPHLLSNEHLNKNLGRTAADSEGCLQLCLEEVANGLRNPLAMVHANDGTHRFFVAEQVGLVWVYLPDQSKLEKPFLNITKAVLTSPWEGDERGFLGLTFHPRFKYNGKLYVYYSVEVGFDERIRISEFRISSTDMNVVDHTSERIILEIDEPASNHNGGQLLFADDGYLYIFTGDGGMAGDPFGKFGNAQNKSALLGKVLRIDVDDNERGPLYRIPADNPFVHEPKARPEVYAYGVRNMWRCSVDRGDPITKEGRGRIFCGDVGQNKYEEVDIVEKGRNYGWRAKEGFSCYDKKLCANSSLDDVLPIYAYPHKMGKSVTGGYVYRGCENPNLNGLYIFGDFMSGRLMSLKENRQTGNWEYNEICMGIGLTCSFPGLINNYYPYIISFAEDEAGELYFMSTEIPSATSPTGVVYKIVDPSRRAPPGKCHYEPHSVRVKSNIIPFEPKETLIGVHIPTKQPKLSNTEEPPLVTTKDWLRELLDNFREEDGQITTTPFTPTTPKPVRTSRQRKGRRRKGKHKNGAVRLVGDEEGQRDRGRVEVYANGEWGTVCDDLWNTKNAVVVCRQLGFLHALKAAKHAEFGEGTGLKIILDDVQCEGTEETLLDCQHAGIGTHNCAHYEDAGVVCGNSVASLQ", "length": 802 }, "evidence": [ { "id": "F1MI35", "url": "https://omabrowser.org/oma/group/F1MI35/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "I3LHD8-1", "protein_name": "HHIP like 1", "gene_name": "", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAGRAGAGAGALLALLALRALGASAHPQCLDFRPPFRPPQPLHFCAQYSAFGCCAPEHDAALARRFGALAARVDPALWAECAGYALDLLCQECSPYAAHLYDAEDPATPLRTVPGLCEDYCLDMWQTCRGLIRHLSPDRELWALEGNRAKFCRYLSLDDVDYCFPRLLVNENLNSNLGRVVADAKGCLQLCLEEVANGLRNPVAMVHARDGTHRFFVAEQLGLVWAYLPDRSRLEKPFLNISRAVLTSPWEGDERGFLGLAFHPRFRHNGKLYVYYSVGVDFHEWIRISEFRVSEDDVNTVDHDSERIILEIEEPASNHNGGQLLFGDDGYLYIFTGDGGMAGDPFGKFGNAQNKSALLGKVLRIDVDRNERGPLYHIPPDNPFVGDPAARPEVYAFGVRNMWRCSFDRGDPASGAGRGRLFCGDVGQNKFEEVDLVERGRNYGWRAREGFECYDRKLCANTSLDDVLPIFAYPHKLGKSVTGGYVYRGCEYPNLNGLYIFGDFMSGRLMSLRENLGTGQWRYSEICMGRGQTCAFPGLINNYYPHVISFAEDEAGELYFMSTGVPSATVARGVVYKMIDPSRRAPPGKCQIQPAHVRLRSRLVPFVPKEKFIRRTESTPRPTARAPTTKAPRRSRPTAAPLAPTPRPARPTGRPGRRRGGGRRRGRPGTADPAPSNGAVRLVRPAGLSPGRGRVEVFAGGRWGTVCDDAWDTKAATVVCRQLGFAYAVRAAKRAEFGEGRALPILLDDVRCEGSERNLLECAHAGLGSHNCGHQEDAGVVCSREDPDL", "length": 789 }, "evidence": [ { "id": "F1MI35", "url": "https://omabrowser.org/oma/group/F1MI35/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q14DK5-1", "protein_name": "HHIP-like protein 1", "gene_name": "Hhipl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGRRAVARIGPGALLVLRALLAAAHPQCLDFRPPFRPPQPLSFCAQYSAFGCCTAEQDAALARRFRVLETRMDAGVWATCAGYALDLLCQECSPYAAHLYDAEDPATPLRTVPGLCEDYCLDMWQTCRGLFRLLSPDRELWALESNRAKLCRYLSLDDTDYCFPSLLVNENLNSNLGRVVADAKGCLQLCLEEVANGLRNPVAMVHAGDGSHRFFVAEQVGLVWTYLPDRSRLEKPFLNVSQAVLTSPWEGDERGFLGLAFHPRFPHPSKLYVYYSVGVGFREWIRISEFRVSEGDENTVDHGSERIILEIEEPASNHNGGQLLFGDDGFLYIFTGDGGMAGDPFGKFGNAQNKSALLGKVLRIDVDRKERGLHYGIPPDNPFVDDPGARPEVYALGVRNMWRCSFDRGDPMSGTGRGRLFCGDVGQNKYEEVDLVERGRNYGWRAREGFECYDRKLCANTSLDDVLPIFAYPHKLGKSVTGGYVYRGCEYPNLNGLYIFGDFMSGRLMSLRENPETGQWKYSEVCMGRGQTCAFPGLINNYYPYIISFAEDEAGELYFMSTGVPSATAAHGVIYKVIDPSRRAPPGKCKIRPAQVKVRSHLIPFVPKEKFIRTPESTPRPTARAPTKAPRRRRPTAAPPAPTPRPTKPARPTRRPGARKGGGRRRGRPSTAVPEPENGSVRLVRPAGLSPGRGRVEVFIGGRWGTVCDDAWDTKAAAVVCRQLGFAHAVRAAKRAEFGEGRALRILLDDVRCAGSERNLLECAHAGVGTHNCKHDEDAGVECSHQDPNL", "length": 791 }, "evidence": [ { "id": "F1MI35", "url": "https://omabrowser.org/oma/group/F1MI35/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96JK4-1", "protein_name": "HHIP-like protein 1", "gene_name": "HHIPL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MARARAGALLALWVLGAAAHPQCLDFRPPFRPTQPLRLCAQYSDFGCCDEGRDAELTRRFWALASRVDAAEWAACAGYARDLLCQECSPYAAHLYDAEDPFTPLRTVPGLCQDYCLDMWHKCRGLFRHLSTDQELWALEGNLARFCRYLSLDDTDYCFPYLLVNKNLNSNLGHVVADAKGCLQLCLEEVANGLRNPVAMVHARDGTHRFFVAEQVGLVWAYLPDRSRLGKPFLNISRVVLTSPWEGDERGFLGIAFHPSFQHNRRLYVYYSVGIRSSEWIRISEFRVSEDDENAVDHSSERIILEVKEPASNHNGGQLLFGDDGYLYIFTGDGGMAGDPFGTFGNAQNKSALLGKVLRIDVDRKERGLPYGIPPDNPFVGDPAAQPEVYALGVRNMWRCSFDRGDPSSGTGRGRLFCGDVGQNKFEEVDVVERGGNYGWRAREGFECYDRSLCANTSLNDLLPIFAYPHTVGKSVTGGYVYRGCEYPNLNGLYIFGDFMSGRLMSLQENPGTGQWQYSEICMGHGQTCEFPGLINNYYPYIISFGEDEAGELYFMSTGEPSATAPRGVVYKIIDASRRAPPGKCQIQPAQVKIRSRLIPFVPKEKFIPKTRSTPRPTARAPTRAPRRGRPTAAPPAPTPRPARPTQQPGSRRGGGRRRGRLNSASRAFRDGEVRLVRPAGLSSGSGRVEVFVGGRWGTVCDDSWNISGAAVVCRQLGFAYAVRAVKRAEFGQGGSLPILLDDVRCAGWERNLLECQHNGVGTHNCEHDEDAGVVCSHQNPDL", "length": 782 }, "evidence": [ { "id": "F1MI35", "url": "https://omabrowser.org/oma/group/F1MI35/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9SSG3-1", "protein_name": "HIPL1 protein", "gene_name": "HIPL1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MKLHQFLVFLFLFLSCFALSSWALPLCSDSRAPSEVNSTLSFCPYKGKTCCNTMKDTSLMKQFQAMNISDKGCASVVKSILCANCDPFSSDLFRDNSDQQSVPILCNSTSSANSTENFCSETWETCQNVSISGSLFAASLQGRAGAPSNKNASKLADLWQSKTDFCSAFGGASSNETVCFSGEPVALNDNDTTPDKPPSGICLEKIGNGSYLNMVPHPDGSNRAFFSTQPGIVFLAGIPDQDSGGVLDVDPSSPFVDMTDEIHFDTEFGMMGMAFHPKFAQNGRFFASFNCDKSKWPGCTGRCSCNSDVNCDPSKLTPDSGSQPCQYQTVIAEYTANSTSSDPSKAKNAKPTEVRRIFTMGLPFTSHHAGQILFGPDGYLYFMMGDGGGGADPYNFAQNKKSLLGKIMRLDVDNIPSASEISKMGLWGNYSIPKDNPFREDKELEPEIWAVGLRNPWRCSFDSSRPSYFMCADVGQDTYEEVDLISKGGNYGWRVYEGPDLFHPESSPGGNTSVKSLNPIFPVMGYNHSEVDSSGKSASITGGYFYRSETDPCIAGRYVYADLYGNGVWAGIETPANSGSFVTKRTTFSCASDSPMKCSDSPGTSGLSLGYVFSFGEDNNKDIYLLTSNGVYRVVRPSRCNLTCSKENSTARRNPGTSSSPSSSSSSCYKHINGFHGSLVVLFVSLSLILLGLLN", "length": 695 }, "evidence": [ { "id": "F1MI35", "url": "https://omabrowser.org/oma/group/F1MI35/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MI35", "url": "https://www.uniprot.org/uniprotkb/F1MI35" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MI35", "url": "https://www.uniprot.org/uniprotkb/F1MI35" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 357, "end_pos": 359, "annotation": "n_glycosylation_sequon" }, { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MI35-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 786, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MI35-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MI35" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MI35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI35" }, { "id": "PS50287", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50287" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SRCR", "eco_id": "ECO_0000259", "start_pos": 677, "end_pos": 780, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 642 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 243, "end_pos": 245 }, { "start_pos": 357, "end_pos": 359 }, { "start_pos": 464, "end_pos": 466 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MI74-1", "uniprot_ac": "F1MI74", "uniprot_id": "F1MI74_BOVIN", "mass": { "chemical_mass": 118244.0, "monoisotopic_mass": 118244.0 }, "refseq": { "ac": "NP_001179480", "name": "NACHT, LRR and PYD domains-containing protein 12", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179480" }, "gene_names": [ { "name": "NLRP12", "type": "recommended", "evidence": [ { "id": "F1MI74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI74" } ] }, { "name": "NLRP12", "type": "synonym", "evidence": [ { "id": "NP_001179480", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179480" } ] } ], "protein_names": [ { "name": "NACHT, LRR and PYD domains-containing protein 12", "type": "recommended", "evidence": [ { "id": "F1MI74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI74/entry#names_and_taxonomy" } ] }, { "name": "Monarch-1", "type": "synonym", "evidence": [ { "id": "F1MI74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI74/entry#names_and_taxonomy" } ] }, { "name": "NACHT, LRR and PYD domains-containing protein 12", "type": "synonym", "evidence": [ { "id": "NP_001179480", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179480" } ] }, { "name": "PYRIN-containing APAF1-like protein 7", "type": "synonym", "evidence": [ { "id": "F1MI74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI74/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways. Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway. In turn, promotes bacterial tolerance. Also inhibits the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation. Also acts as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue.", "evidence": [ { "database": "UniProtKB", "id": "F1MI74", "url": "https://www.uniprot.org/uniprotkb/F1MI74#function" }, { "database": "UniProtKB", "id": "ARBA00056883", "url": "https://www.uniprot.org/uniprotkb/ARBA00056883#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MI74", "url": "https://www.uniprot.org/uniprotkb/F1MI74" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NLRP12", "url": "https://www.uniprot.org/uniprotkb/F1MI74", "locus": { "chromosome": "18", "start_pos": 60905906, "end_pos": 60925608, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038149", "url": "https://www.ensembl.org/id/ENSBTAG00000038149" } ] } } ], "crossref": [ { "id": "F1MI74", "url": "https://alphafold.ebi.ac.uk/entry/F1MI74", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000038149", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038149", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00116", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00116", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08320", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08320", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "522018", "url": "https://www.ncbi.nlm.nih.gov/gene/522018", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007111", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007111", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011029", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011029", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029495", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029495", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050637", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050637", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:522018", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522018", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TTAVYMF", "url": "https://omabrowser.org/oma/group/TTAVYMF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MI74", "url": "https://www.orthodb.org/?gene=F1MI74", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45690", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45690", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45690:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45690:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02758", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02758", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05729", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05729", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14484", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14484", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17776", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17776", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17779", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17779", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179480", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MI74", "url": "https://www.uniprot.org/uniprotkb/F1MI74", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MI74-1", "url": "https://www.uniprot.org/uniprotkb/F1MI74-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPAPLRSDLGRLCTYLEELEAVELKKFKLYLGTATEMGEGKIPWGRMEQAGPLEMAQLLAAHFGPQEAWLLALSVFHQINRKDLWERGHREDQGKDAPSGGPPSLGSESACSLDVLAAAPRKDPQETYRDYVRRKFRLMEDRNARLGEFVNLSHRYTRLLLAKEHSSPRWAQQKLLDTGRGHAGTAGHPASLIQIEALFEPDEERPEPPRTVVLQGAAGMGKSMLAHKVMLDWADGKLFQNRFDYVCYINCREMNRGTAELSVRDLLASCWPEPCAPLQELVRVPERLLVIMDGFDELRPSFHEPQGPWCLCWEKKAPAEVLLGSLIRKKLLPELSLLITTRPTALAKLQRSLEHPRHVAILGFSEAERKEYFHRYFHDREQASQVFSFVRDDEPLFTLCFVPMVCWVVCTCLKQQLEGGGLLRRRSRTTTAVYLLYLLSLMQPKPGTPTLPSPPNRRGLCALAAHGLWEQKILFAERDLREHGLDAADVSSFLNMNIFQKDIICETLYSFIHLSFQEFFAAMHYVLDDGASGSGPERNLSRLLTEYAFSDRSFLALTVRFLFGLLNEETRSYLEKTLGWKVSPGVKTELLEWIRRKARSEGSTLKQGALEVFGCLYELQEEEFIQQALSHFQVVVVNNITTKMEHMVSSFCVKSCRNAEVLQLFGAAYQAHGEDRLRWPLATSPERHVLPDIYSEQLAAALSTNPSLVELALHSNALGSQGVKLLCQGLRHPNCRLQNLRLKRCQVSSSVCQDLTTALIANKHLLRMDLSGNALGLLGAQLLCQGLRHPKCRLQVVQLRKCHLEAGACQELASVLSTSRHLLELDLTGNALEDSGLRLLCQGLRHPVCRLRILWLKICLLTGAACEDLASTLHMNQSLVELDLSLNDLGDPGVLLLCEGLRHPQCKLQTLRLCICRLSSVACEGLSAVLGVSSHLRELDLSFNDLGDRGMSLLCEGLRHPTCRLQKLLDSCSLTGKACEDISSALGINQTLTDLYLTNNALGNTGVRLLCERLSHPGCKLRVLWLFGMDLNKMTHRSLEALRMTKPYLDVGC", "length": 1054, "header": "tr|F1MI74-1|F1MI74_BOVIN Isoform 1 of NACHT, LRR and PYD domains-containing protein 12 OS=Bos taurus OX=9913 GN=NLRP12 PE=3 SV=3 CANONICAL=F1MI74-1" }, "isoforms": [ { "isoform_ac": "F1MI74-1", "url": "https://www.uniprot.org/uniprotkb/F1MI74/entry", "sequence": { "sequence": "MSPAPLRSDLGRLCTYLEELEAVELKKFKLYLGTATEMGEGKIPWGRMEQAGPLEMAQLLAAHFGPQEAWLLALSVFHQINRKDLWERGHREDQGKDAPSGGPPSLGSESACSLDVLAAAPRKDPQETYRDYVRRKFRLMEDRNARLGEFVNLSHRYTRLLLAKEHSSPRWAQQKLLDTGRGHAGTAGHPASLIQIEALFEPDEERPEPPRTVVLQGAAGMGKSMLAHKVMLDWADGKLFQNRFDYVCYINCREMNRGTAELSVRDLLASCWPEPCAPLQELVRVPERLLVIMDGFDELRPSFHEPQGPWCLCWEKKAPAEVLLGSLIRKKLLPELSLLITTRPTALAKLQRSLEHPRHVAILGFSEAERKEYFHRYFHDREQASQVFSFVRDDEPLFTLCFVPMVCWVVCTCLKQQLEGGGLLRRRSRTTTAVYLLYLLSLMQPKPGTPTLPSPPNRRGLCALAAHGLWEQKILFAERDLREHGLDAADVSSFLNMNIFQKDIICETLYSFIHLSFQEFFAAMHYVLDDGASGSGPERNLSRLLTEYAFSDRSFLALTVRFLFGLLNEETRSYLEKTLGWKVSPGVKTELLEWIRRKARSEGSTLKQGALEVFGCLYELQEEEFIQQALSHFQVVVVNNITTKMEHMVSSFCVKSCRNAEVLQLFGAAYQAHGEDRLRWPLATSPERHVLPDIYSEQLAAALSTNPSLVELALHSNALGSQGVKLLCQGLRHPNCRLQNLRLKRCQVSSSVCQDLTTALIANKHLLRMDLSGNALGLLGAQLLCQGLRHPKCRLQVVQLRKCHLEAGACQELASVLSTSRHLLELDLTGNALEDSGLRLLCQGLRHPVCRLRILWLKICLLTGAACEDLASTLHMNQSLVELDLSLNDLGDPGVLLLCEGLRHPQCKLQTLRLCICRLSSVACEGLSAVLGVSSHLRELDLSFNDLGDRGMSLLCEGLRHPTCRLQKLLDSCSLTGKACEDISSALGINQTLTDLYLTNNALGNTGVRLLCERLSHPGCKLRVLWLFGMDLNKMTHRSLEALRMTKPYLDVGC", "length": 1054, "header": "tr|F1MI74-1|F1MI74_BOVIN Isoform 1 of NACHT, LRR and PYD domains-containing protein 12 OS=Bos taurus OX=9913 GN=NLRP12 PE=3 SV=3 CANONICAL=F1MI74-1" }, "locus": { "chromosome": "18", "start_pos": 60925131, "end_pos": 60906310, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000057509.4", "url": "https://www.ensembl.org/id/ENSBTAT00000057509.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000051805.3", "url": "https://www.ensembl.org/id/ENSBTAP00000051805.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:522018", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:522018", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JW23-1", "protein_name": "NACHT, LRR and PYD domains-containing protein 12", "gene_name": "Nlrp12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLPATAKDALHRLSTYLEELEAGELKKFKLYLGIAEELGQDKIPRGRMEMAGPLEMAQLMVAHMGTKEAWLLALSTFERIHRKDLWERGQGEDLVRVTPSNGLCSLESQSTCLSDVSPDAPRKDPQITYKDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPIWAQQKLLETGWEHSRTRGHQASPIQMETLFEPDEERPEPPRTVVLQGAAGMGKSMLTHKVMLDWADGRLFQDQFDYVFYISCRELNRSHTQCSVHDLLSSCWPEHGAPLEDLIRAPDRLLFIIDGFHELHPSFHDVQGPWCHCWEEKRPTELLLGSLIRRLLLPQLSLLITTRPCALEKLHGLLEHPRHVEILGFSEAEREEYFYRYFHNTGQASQVFSFMRDYEPLFTMCFVPMVSWVVCTCLKQQLESGELLRQTSRTTTAVYMFYLLSLMQPKPGTPTFKVPANQRGLVSLAAEGLWNQKILFEEEDLGKHGLDGAEVSTFLNVNIFQKGIKCEKFYSFIHLSFQEFFTAMYCALHGREAVRRALAEYGFSERNFLAHTVRFLFGLLNEEMRCYLERNLGWTISPQVKEEALAWIQNKARSEGSTLQHGSLELLSCLYEIQEEDFIQQALSHFQVVVVRNLSTKMEHVVCSFCARYCRGTEVLHLYGSAYSTGAEDGPPEPPGAQTQSTHSQERNILPDIYSAYLSATICTNSNLIELALYRNALGSQGVRLLCQGLRHANCKLQNLRLKRCHISGSACQDLAAAIIANRNLIRLDLSGNSIGVLGLELLCEGLQHPMCRLQMIQLRKCLLEAAAGRALASVLSNNSHLVELDLTGNPLEDLGLKLLCQGLRHPVCRLRTLWLKICHLGQASCEDLASTLKMNQSLMELDLGLNDLGDSGALLLCEGLRHPDCKLQTLRLGICRLGSDACAGVASVLQVNTCLRELDLSFNDLGDRGLWLLGEGLRHQTCRLQKLWLDSCGLTSKACEDLSSVLGISQTLNELYLTNNALGDTGVRLLCKRLRHPGCKLRVLWLFGMDLNKVTHRRMAALRVTKPYLDIGC", "length": 1054 }, "evidence": [ { "id": "F1MI74", "url": "https://omabrowser.org/oma/group/F1MI74/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E9Q5R7-1", "protein_name": "NACHT, LRR and PYD domains-containing protein 12", "gene_name": "Nlrp12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPSTARDGLYRLSTYLEELEAGELKKFKLFLGIAEDLSQDKIPWGRMEKAGPLEMAQLMVAHMGTREAWLLALSTFQRIHRKDLWERGQGEDLVRVTPNNGLCLFESQSACPLDVSPNAPRKDLQTTYKDYVRRKFQLMEDRNARLGECVNLSNRYTRLLLVKEHSNPIWTQQKFVDVEWERSRTRRHQTSPIQMETLFEPDEERPEPPHTVVLQGAAGMGKSMLAHKVMLDWADGRLFQGRFDYVFYISCRELNRSHTQCSVQDLISSCWPERGISLEDLMQAPDRLLFIIDGFDKLHPSFHDAQGPWCLCWEEKQPTEVLLGSLIRRLLLPQVSLLITTRPCALEKLHGLLEHPRHVEILGFSEEARKEYFYRYFHNTGQASRVLSFLMDYEPLFTMCFVPMVSWVVCTCLKQQLESGELLRQTPRTTTAVYMFYLLSLMQPKPGTPTFKVPANQRGLVSLAAEGLWNQKILFDEQDLGKHGLDGADVSTFLNVNIFQKGIKCEKFYSFIHLSFQEFFAAMYCALNGREAVRRALAEYGFSERNFLALTVHFLFGLLNEEMRCYLERNLGWSISPQVKEEVLAWIQNKAGSEGSTLQHGSLELLSCLYEVQEEDFIQQALSHFQVVVVRSISTKMEHMVCSFCARYCRSTEVLHLHGSAYSTGMEDDPPEPSGVQTQSTYLQERNMLPDVYSAYLSAAVCTNSNLIELALYRNALGSQGVRLLCQGLRHASCKLQNLRLKRCQISGSACQDLAAAVIANRNLIRLDLSDNSIGVPGLELLCEGLQHPRCRLQMIQLRKCLLEAAAGRSLASVLSNNSYLVELDLTGNPLEDSGLKLLCQGLRHPVCRLRTLWLKICHLGQASCEDLASTLKMNQSLLELDLGLNDLGDSGVLLLCEGLSHPDCKLQTLRLGICRLGSVACVGIASVLQVNTCLQELDLSFNDLGDRGLQLLGEGLRHQTCRLQKLWLDNCGLTSKACEDLSSILGISQTLHELYLTNNALGDTGVCLLCKRLRHPGCKLRVLWLFGMDLNKKTHRRMAALRVTKPYLDIGC", "length": 1054 }, "evidence": [ { "id": "F1MI74", "url": "https://omabrowser.org/oma/group/F1MI74/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P59046-1", "protein_name": "NACHT, LRR and PYD domains-containing protein 12", "gene_name": "NLRP12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC", "length": 1061 }, "evidence": [ { "id": "F1MI74", "url": "https://omabrowser.org/oma/group/F1MI74/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MI74", "url": "https://www.uniprot.org/uniprotkb/F1MI74" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MI74", "url": "https://www.uniprot.org/uniprotkb/F1MI74" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "negative regulation of inflammatory response", "id": "GO:0050728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728", "evidence": [ { "database": "UniProtKB", "id": "F1MI74", "url": "https://www.uniprot.org/uniprotkb/F1MI74" } ], "pmid": "" }, { "name": "negative regulation of canonical NF-kappaB signal transduction", "id": "GO:0043124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043124", "evidence": [ { "database": "UniProtKB", "id": "F1MI74", "url": "https://www.uniprot.org/uniprotkb/F1MI74" } ], "pmid": "" }, { "name": "regulation of inflammatory response", "id": "GO:0050727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050727", "evidence": [ { "database": "UniProtKB", "id": "F1MI74", "url": "https://www.uniprot.org/uniprotkb/F1MI74" } ], "pmid": "" }, { "name": "negative regulation of non-canonical NF-kappaB signal transduction", "id": "GO:1901223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901223", "evidence": [ { "database": "UniProtKB", "id": "F1MI74", "url": "https://www.uniprot.org/uniprotkb/F1MI74" } ], "pmid": "" }, { "name": "positive regulation of MHC class I biosynthetic process", "id": "GO:0045345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045345", "evidence": [ { "database": "UniProtKB", "id": "F1MI74", "url": "https://www.uniprot.org/uniprotkb/F1MI74" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 540, "end_pos": 542, "annotation": "n_glycosylation_sequon" }, { "start_pos": 640, "end_pos": 642, "annotation": "n_glycosylation_sequon" }, { "start_pos": 877, "end_pos": 879, "annotation": "n_glycosylation_sequon" }, { "start_pos": 990, "end_pos": 992, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MI74-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1054, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MI74-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MI74" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MI74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI74" }, { "id": "PS50837", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50837" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "NACHT", "eco_id": "ECO_0000259", "start_pos": 211, "end_pos": 528, "start_aa": "Arg", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MI74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI74" }, { "id": "PS50824", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50824" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Pyrin", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 95, "start_aa": "Met", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 152, "end_pos": 154 }, { "start_pos": 540, "end_pos": 542 }, { "start_pos": 640, "end_pos": 642 }, { "start_pos": 877, "end_pos": 879 }, { "start_pos": 990, "end_pos": 992 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"length": 2562, "header": "tr|F1MIB3-1|F1MIB3_BOVIN Isoform 1 of Zinc finger protein 462 OS=Bos taurus OX=9913 GN=ZNF462 PE=4 SV=4 CANONICAL=F1MIB3-1" }, "isoforms": [ { "isoform_ac": "F1MIB3-1", "url": "https://www.uniprot.org/uniprotkb/F1MIB3/entry", "sequence": { "sequence": "MMEVLQCDGCDFRAPSYEDLKAHIQDVHTAFLQPTDVAEDNANESRSGSMNASNQTEVEFSSIKDEFAIAEDLTGQNAAALGTGSYYGHSPGYYSQHIAPNPKPTNKFFQCKFCVRYFRSKNLLIEHTRKVHGAQAEGSSAGPPVPGSLNYNIMMHEGFGKVFSCQFCTYKSPRRARIIKHQKMYHKNNLKETTAPPPAPAPMPDPVVPPMSLQDPCKELPAEVVERSILESMVKPLTKSRGNFCCEWCSYQTPRRERWCDHMMKKHRSMVKILSSLRQQQEGTNVPEAQNKNDLSPTSNSTYLSMNAASRELPNTNVSNFRGSIGNSIMRPNSSSTSKFSPMSYPQMKPKSPHNSGLVNLAERSRYGMPDMTNSADLDTNSMLNDSSSDEELNEIDSENGLNAMDHQTVGMSAEQLMGSEGNKLLETKGIPFRRFMNRFQCPFCPFLTMHRRSISRHIENIHLSGKTAVYKCDECPFTCKSSLKLGAHKQCHTGTTSDWDAVNSQSEGISSSLNEGVVSYESSSINGRKSGVLLDPLQQQQPPPPPPPPPPPPPSQPQPPQLQSPHQVPPQPQLPPPPPPPPAQAPPLHPYKCTMCNYSTTTLKGLRVHQQHKHSFCDNLPKFEGQTSSLPLDSETDSHPSSSNTVKKSQTSILGLSSKNNFVAKASRKLANDFPLDLSPVKKRTRIDEIASNLQSKINQTKQQEDAVINVEDDEEEEEDNEVEIEVELDREEEPPEPILEVPTPFSAQQIWARDAPEPPKEPNFRTVAHDYNATNGAEIELTLSEDEEDYYGSSTNMKDHQVSNTTLLNTQTPIYASEHNNENTDFSDSGRLYYCKHCDFNNKSARSVSTHYQRMHPYIKFSFRYILDPNDHSAVYRCLECYIDYTNFEDLQQHYGEHHPEAMNVLNFDHSDLIYRCRFCSYTSPNVRSLMPHYQRMHPTVKINNAMIFSSYVVEQQEGLGTESQTLREILNSAPKNMATSTPMARGGGMPAPYPKNTPSKTFPPECENQKDPSVNTVVVYDCDVCSFASPNMHSVLVHYQKKHPEEKASYFRIQKTMRMVSVDRGSALSQLSFEVGAPMSPKMSTMGSPPPPQPPPPDLSTELYYCKHCSYSNRSVVGVLVHYQKRHPEIKVTAKYIRQAPPTAAMMRGPEGPHGSPRPPAPMQQLNRSSSERDGPPVENEMFFCQHCDYGNRTVKGVLIHYQKKHRDFKANADVIRQHTATIRSLCDRNQKKPASCMLVSPSGVERDKTKLRALKCRQCSYTSPYFYALRKHIKKDHPALKATVTSIMRWAFLDGLIEAGYHCEWCIYSHTEPSGLLLHYQRRHPEHYVDYTYMATKLWAGPDPSPPSLTMPAEAKTYRCRDCVFEALSIWDITNHYQAFHPWAMNGDESVLLDIIKEKDAVENPMSSSEDLVGTVSCENSMPGPLAEQEGECPEDARLSPEKTIQLASVNPAISSTPYQCTVCQSEYNNLHGLLTHYGKKHPGMKVKAADFAQDIDINPGAVYKCRHCPYINTRIHGVLTHYQKRHPSIKVTAEDFVHDVEQSTDIAQNDVEETSRIFKQGYGAYRCKLCPYTHGTLEKLKIHYEKYHNQPEFDVFSQSPPKLPMSLEPEITTEVSPSQVSVTEDEVGEEPVSTSHFATSHLVSHTVFRCQLCKYFCSTRKGIARHYRIKHNNVRAQPEGKNNLFKCALCAYTNPIRKGLAAHYQKRHDIDAYYTHCLAASRTISDKPNKVIIPSPPKDDSPPLSEELRRAVEKKKCSLCAFQSFSKKGIVSHYMKRHPGVFPKKQHASKLGGYFTAVYADEHEKPVLMEDSEERGGFEKAEVEGNEGQDIEWLPFRCIKCFKLSFSTAELLSMHYTDHHSRDLKRDFVILGGGPRLQGSAYQCKHCESRLQSTAELTSHLNIHNEEFQKRAKRQERRKQLLSKQKYADGAFADFKQERPFGHLEEVPKIKERKVVGYKCKFCVEVHPTLRAICNHLRKHVQYGSVPAVSAAVKQEAEDPSHLFLDGLEAAKDATGALVDRVDGEHCLLDGMLEDETRPGGYHCSQCDRVLMSMQGLRSHERSHLALAMFTREDKYSCQYCSFVSAFRHNLDRHMQTHHGHHKPFRCKLCSFKSSYNSRLKTHVLKAHAGEHAYKCSWCSFSTMTISQLKEHSLKVHGKALTLPRPRIVSLLSSHAHHSSQKATPAEEVEDSNDSSYSEPPDVQQQLNHYQSAALARNNSRVSPVPLSGAAGGAEQKTEAILHCEFCEFSSGYIQSIRRHYRDKHGGKKLFKCKDCSFYTGFKSAFTMHVEAGHSAVPEEGPKDLRCPLCLYHTKYKRNMIDHIVLHREERVVPIEVCRSKLSKYLQGVVFRCDKCTFTCSSDESLQQHIEKHNELKPYKCQLCYYETKHTEELDSHLRDEHKVSRNFELVGRVNLDQLEQMKEKMESSSSDDEDKEEEMNSKADDRDLLRFSDRGAAINTEKRFPCEFCGRAFSQGSEWERHVLRHGMALNDTKQVSREEIHLKGNMEDSIKMPSIEEKEDDETIGIDFSLKNEPVAICVVAADKSLLENAEAKKE", "length": 2562, "header": "tr|F1MIB3-1|F1MIB3_BOVIN Isoform 1 of Zinc finger protein 462 OS=Bos taurus OX=9913 GN=ZNF462 PE=4 SV=4 CANONICAL=F1MIB3-1" }, "locus": { "chromosome": "8", "start_pos": 96757970, "end_pos": 96663549, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025536.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025536.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025536.7", "url": "https://www.ensembl.org/id/ENSBTAP00000025536.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "F1MIB3", "url": "https://www.uniprot.org/uniprotkb/F1MIB3" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MIB3", "url": "https://www.uniprot.org/uniprotkb/F1MIB3" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "F1MIB3", "url": "https://www.uniprot.org/uniprotkb/F1MIB3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MIB3", "url": "https://www.uniprot.org/uniprotkb/F1MIB3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MIB3", "url": "https://www.uniprot.org/uniprotkb/F1MIB3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MIB3", "url": "https://www.uniprot.org/uniprotkb/F1MIB3" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1MIB3", "url": "https://www.uniprot.org/uniprotkb/F1MIB3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1116, "end_pos": 1118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1170, "end_pos": 1172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1195, "end_pos": 1197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2198, "end_pos": 2200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2223, "end_pos": 2225, "annotation": 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"annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MIB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB3" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 109, "end_pos": 137, "start_aa": "Phe", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1116, "end_pos": 1118 }, { "start_pos": 1170, "end_pos": 1172 }, { "start_pos": 1195, "end_pos": 1197 }, { "start_pos": 2198, "end_pos": 2200 }, { "start_pos": 2223, "end_pos": 2225 }, { "start_pos": 2497, "end_pos": 2499 }, { "start_pos": 300, "end_pos": 302 }, { "start_pos": 317, "end_pos": 319 }, { "start_pos": 333, "end_pos": 335 }, { "start_pos": 385, "end_pos": 387 }, { "start_pos": 43, "end_pos": 45 }, { "start_pos": 51, "end_pos": 53 }, { "start_pos": 54, "end_pos": 56 }, { "start_pos": 598, "end_pos": 600 }, { "start_pos": 700, "end_pos": 702 }, { "start_pos": 774, "end_pos": 776 }, { "start_pos": 806, "end_pos": 808 }, { "start_pos": 844, "end_pos": 846 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MIF7-1", "uniprot_ac": "F1MIF7", "uniprot_id": "F1MIF7_BOVIN", "mass": { "chemical_mass": 32952.0, "monoisotopic_mass": 32952.0 }, "refseq": { "ac": "NP_001377165", "name": "olfactory receptor family 4 subfamily H member 12", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377165" }, "gene_names": [ { "name": "OR4H12", "type": "recommended", "evidence": [ { "id": "F1MIF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIF7" } ] }, { "name": "OR4H12", "type": "synonym", "evidence": [ { "id": "NP_001377165", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377165" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1MIF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIF7/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 4S2", "type": "synonym", "evidence": [ { "id": "NP_001377165", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377165" } ] }, { "name": "olfactory receptor family 4 subfamily H member 12", "type": "synonym", "evidence": [ { "id": "NP_001377165", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377165" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001377165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377165" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MIF7", "url": "https://www.uniprot.org/uniprotkb/F1MIF7#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MIF7", "url": "https://www.uniprot.org/uniprotkb/F1MIF7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR4H12", "url": "https://www.uniprot.org/uniprotkb/F1MIF7", "locus": { "chromosome": "10", "start_pos": 27174489, "end_pos": 27173611, "strand": "-", "evidence": 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Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. 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"glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1C6N9-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 7", "gene_name": "MED7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGEPQQVSALPPPPMQYIKEYTDENIRKGLAPKPPPPVKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILVNFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVVEMIQNCLASLPDDLPHSEGGLGVKTEPMDTDDGSNCIGQSEKQRDRSGCKRDQVLDKDAAMCSIIDEMT", "length": 230 }, "evidence": [ { "id": "F1MIJ0", "url": "https://omabrowser.org/oma/group/F1MIJ0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3I4G3-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 7", "gene_name": "Med7", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKTEPMDTDDNSNCTGQNEQQRENSGHRRDQIIEKDAALCVLVDEMNERP", "length": 233 }, "evidence": [ { "id": "F1MIJ0", "url": "https://omabrowser.org/oma/group/F1MIJ0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O43513-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 7", "gene_name": "MED7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKTEPMDADDSNNCTGQNEHQRENSGHRRDQIIEKDAALCVLIDEMNERP", "length": 233 }, "evidence": [ { "id": "F1MIJ0", "url": "https://omabrowser.org/oma/group/F1MIJ0/", "database": "OMA" } ], "glygen_name": 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"MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKAEPMDADDSNNCTGQSDQQRENSGHRRDQIIEKDAALCVLIDEMNERP", "length": 233 }, "evidence": [ { "id": "F1MIJ0", "url": "https://omabrowser.org/oma/group/F1MIJ0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9CZB6-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 7", "gene_name": "Med7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKAEPMDTDDNSNCPGQNEQQRESSGHRRDQIIEKDAALCVLIDEMNERP", "length": 233 }, "evidence": [ { "id": "F1MIJ0", "url": "https://omabrowser.org/oma/group/F1MIJ0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9GYV9-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 7", "gene_name": "MED7", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSNQETQVSSLPMPPERYIANYTDENIRRNRAPRPPPPPAQHEVYSMFGIQYNNDEMIRSLESQNIKRLIPIHFDRRKELKKLNHSLLVNFLDLIDFLILNPDSPRRTEKIDDISLLFVNMHHLLNEFRPHQARETLRVMMEMQKRQRVETAARFQKHLERVREIVNTAFSALPVLDDDDDSGGAKIKTEVDPLEANAAAKNDPSYQHDRMLCKLVDAIE", "length": 220 }, "evidence": [ { "id": "F1MIJ0", "url": "https://omabrowser.org/oma/group/F1MIJ0/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9LYW3-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 7a", "gene_name": "MED7A", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MATATYPPPPPYYRLYKDYSENPNSAPEPPPPIEGTYVCFGGNYTTEDVLPSLEEQGVPQLYPKDSNLDYKNELRSLNRELQLHILELADVLVDRPSQYAKRIGEISSIFKNLHHLLNSLRPHQARATLIHIMELQIQQRKQAVEDIKRRREEAQRLLKDAYLTLDGQ", "length": 168 }, "evidence": [ { "id": "F1MIJ0", "url": "https://omabrowser.org/oma/group/F1MIJ0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MIJ0", "url": "https://www.uniprot.org/uniprotkb/F1MIJ0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MIJ0", "url": "https://www.uniprot.org/uniprotkb/F1MIJ0" } ], "pmid": "" } ] }, { "name": "Cellular Component", 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"name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MIJ6", "url": "https://www.uniprot.org/uniprotkb/F1MIJ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CCNL2", "url": "https://www.uniprot.org/uniprotkb/F1MIJ6", "locus": { "chromosome": "16", "start_pos": 51145733, "end_pos": 51137600, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004873", "url": "https://www.ensembl.org/id/ENSBTAG00000004873" } ] } } ], "crossref": [ { "id": "F1MIJ6", "url": "https://alphafold.ebi.ac.uk/entry/F1MIJ6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004873", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004873", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20590", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20590", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20593", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20593", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538796", "url": "https://www.ncbi.nlm.nih.gov/gene/538796", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004367", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004367", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006671", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006671", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538796", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538796", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NYEEVML", "url": "https://omabrowser.org/oma/group/NYEEVML/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MIJ6", "url": "https://www.orthodb.org/?gene=F1MIJ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10026", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10026", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00134", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00134", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21797", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21797", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001029822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029822", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MIJ6", "url": "https://www.uniprot.org/uniprotkb/F1MIJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIJ6-1", "url": "https://www.uniprot.org/uniprotkb/F1MIJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAAGAGAPGSTAPAVPAGTPGSGGTAPASQGVLIGDRLYSGVLITLENCLLPDDKLRFTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKIEEAPRRIRDVINVFHRLRHLREKKKPVPLLLDQDYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWNYMNDSLRTDVFVRFQPESIACACIYLAARTLEIPLPNRPHWFLLFGATEEEIQEICLKILQLYTRKKVDLTHLESEVEKRRHALDEAKAQAKGLLPGSTQVLDSASRFSPAPKPVESPKEGKGNKPSPLSVKNTKRKVEGVKKTKADSPVNGLPKEQGSRSRSGSHEQSYSRSPSRSASPKRRKSDSGSTSGGSKSQSRSRSRSDSPPRQAHRGAPYKGSKVRSYRRSKDCKYSTQKPHKSRSRSSSRSRSRSRERADTSGKYKKKSHYYREQRRERSRSYERTGHRYERDHPGHSRHRR", "length": 520, "header": "tr|F1MIJ6-1|F1MIJ6_BOVIN Isoform 1 of Cyclin L2 OS=Bos taurus OX=9913 GN=CCNL2 PE=3 SV=2 CANONICAL=F1MIJ6-1" }, "isoforms": [ { "isoform_ac": "F1MIJ6-1", "url": "https://www.uniprot.org/uniprotkb/F1MIJ6/entry", "sequence": { "sequence": "MAAAAGAGAPGSTAPAVPAGTPGSGGTAPASQGVLIGDRLYSGVLITLENCLLPDDKLRFTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKIEEAPRRIRDVINVFHRLRHLREKKKPVPLLLDQDYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWNYMNDSLRTDVFVRFQPESIACACIYLAARTLEIPLPNRPHWFLLFGATEEEIQEICLKILQLYTRKKVDLTHLESEVEKRRHALDEAKAQAKGLLPGSTQVLDSASRFSPAPKPVESPKEGKGNKPSPLSVKNTKRKVEGVKKTKADSPVNGLPKEQGSRSRSGSHEQSYSRSPSRSASPKRRKSDSGSTSGGSKSQSRSRSRSDSPPRQAHRGAPYKGSKVRSYRRSKDCKYSTQKPHKSRSRSSSRSRSRSRERADTSGKYKKKSHYYREQRRERSRSYERTGHRYERDHPGHSRHRR", "length": 520, "header": "tr|F1MIJ6-1|F1MIJ6_BOVIN Isoform 1 of Cyclin L2 OS=Bos taurus OX=9913 GN=CCNL2 PE=3 SV=2 CANONICAL=F1MIJ6-1" }, "locus": { "chromosome": "16", "start_pos": 51145089, "end_pos": 51137653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006407.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006407.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006407.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006407.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 21, "start_aa": "Thr", "end_pos": 21, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr21", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:538796", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538796", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z3K1-1", "protein_name": "Cyclin L2", "gene_name": "CCNL2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAGSGSAAAVAAVAGGGPAGPHAAGVTAGAVTTGSGAPVPGPGAVLIGDRLYSGVLITLENCLLPEHTLRFTPSMSSGLDPDTETELRVTGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKIEEAPRRIRDVINVFHRLRHLREKKKPVPLILDQEYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWNYMNDSLRTDVFVRFQPESIACACIYLAARTLEIPLPNRPHWFLLFGTTEEEIQEICLKILQLYTRKKVDLSDLESKIEKKKLAIEEAKAQAKGLLPEGAPVLDNMSGFSPLPKNESPKEVKGNKPSPLPVQAMKNAKRKAEGAKRTGSNSPVNGVQKGRESRSRSGSRDQSYSRSPSRSASPKHRKSESYSTSSGSKSHSRSRSRSDSPPRQFNHSSTYKSSKMRSYKKSKDYKYSAHKARKSRSRSSSRSRSRSRERSDHSGKYKKKSHYYRNHRHERSRSYERASHRYDRDHPGHSRHRR", "length": 534 }, "evidence": [ { "id": "F1MIJ6", "url": "https://omabrowser.org/oma/group/F1MIJ6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A9J7JDF3-1", "protein_name": "Cyclin-L2 isoform X2", "gene_name": "Ccnl2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAAAAGASVLAAPALAAGSSGSGGAAPGSQGVLIGDRLYSGVLITLENCLLPDDKLRFTPSMSSGLDIDTETGLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKIEEAPRRIRDVINVFHRLRHLREKKKPVPLVLDQEYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTAWNYMNDSLRTDVFVRFQPESIACACIYLAARTLEIPLPNRPHWFLLFGATEEEIQEICFKILQLYTRKKVDLTHLESEVEKRKHAIDEAKARARGLLPGSAPILDSAAGFSPAPKLVESPKEGKGNKSSPLSVKNAKRKVEGPKKAKTDSPVNGLPKGHESRSQSRSREQSYSRSPSRSASPKRRKSESGSTSGGSKSQSRSRSRSDSPPRQVHRGAPYKGSEVRTSRKSKDCKYLTQKPHKSRSRSSSRSRSRSRERTDNSGKYKKKSHYYRDQRRERSRSYERTGHRYERDHPGHSRHRR", "length": 519 }, "evidence": [ { "id": "F1MIJ6", "url": "https://omabrowser.org/oma/group/F1MIJ6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q96S94-1", "protein_name": "Cyclin-L2", "gene_name": "CCNL2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSGVLITLENCLLPDDKLRFTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKIEEAPRRIRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWNYMNDSLRTDVFVRFQPESIACACIYLAARTLEIPLPNRPHWFLLFGATEEEIQEICLKILQLYARKKVDLTHLEGEVEKRKHAIEEAKAQARGLLPGGTQVLDGTSGFSPAPKLVESPKEGKGSKPSPLSVKNTKRRLEGAKKAKADSPVNGLPKGRESRSRSRSREQSYSRSPSRSASPKRRKSDSGSTSGGSKSQSRSRSRSDSPPRQAPRSAPYKGSEIRGSRKSKDCKYPQKPHKSRSRSSSRSRSRSRERADNPGKYKKKSHYYRDQRRERSRSYERTGRRYERDHPGHSRHRR", "length": 520 }, "evidence": [ { "id": "F1MIJ6", "url": "https://omabrowser.org/oma/group/F1MIJ6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MIJ6", "url": "https://www.uniprot.org/uniprotkb/F1MIJ6" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1MIJ6", "url": "https://www.uniprot.org/uniprotkb/F1MIJ6" } ], "pmid": "" }, { "name": "cyclin L-CDK11 complex", "id": "GO:0180038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0180038", "evidence": [ { "database": "UniProtKB", "id": "F1MIJ6", "url": "https://www.uniprot.org/uniprotkb/F1MIJ6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MIJ6", "url": "https://www.uniprot.org/uniprotkb/F1MIJ6" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511053", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511053", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RDTRGHC", "url": "https://omabrowser.org/oma/group/RDTRGHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MIU7", "url": "https://www.orthodb.org/?gene=F1MIU7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43107", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43107", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43107:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43107:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024845723", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845723", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "33639", "url": "https://www.rhea-db.org/rhea/33639", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "54536", "url": "https://www.rhea-db.org/rhea/54536", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MIU7", "url": "https://www.uniprot.org/uniprotkb/F1MIU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIU7-1", "url": "https://www.uniprot.org/uniprotkb/F1MIU7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASLLLLLLLLLLLPLLLLPLRIWSRLRWLAADLAFTMRALRCKRALRARALAAAAADPEGPEGGCSLAWRLAQLARQRPAHTFLIHGAQRFSYAEAERHSNRAARAFLRARGWDGGLGGGGTGGAGEGERAAHCARDQAAGSGAARAVREGDGAAPLAPGATVALLLPACPEFLWLWFGLAKAGLRTAFVPTALRRGPLQHCLRSCGARALVLAPEFLESLEPDLPALRAMGLHLWTVGSDTRPAGISDFLAEASAEVDGPVPGYLSAPQNMTDTCLYIFTSGTTGLPKAARISHLKILQCQAFYQLCGAHQEDVIYLALPLYHMSGSLLGIVGCLGIGATVVLKSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPNKAERGHKVRLVVGSGLRPDTWERFVRRFGPLQVLETYGLTEGNVATFNYTGQQGAVGRASWLYKHVFPFSLIRYDVTTGEPVRDTQGHCVATSPGEPGLLVAPVSQQSPFLGYAGGPELARGKLLKHVFQPGDVFFNTGDLLVCDNQGFLRFHDRTGDTFRWKGENVATTEVAEALEALDFLQEVNVYGVTVPGHEGRAGMAALALRPPHSLDLVQLYAHVSENLPPYARPRFLRLQESLATTETFKQQKVRMAKEGFDPSTLSDPLYILDQAGGAYLPLTPARYSALLAGDLRI", "length": 677, "header": "tr|F1MIU7-1|F1MIU7_BOVIN Isoform 1 of long-chain-fatty-acid--CoA ligase OS=Bos taurus OX=9913 GN=SLC27A3 PE=3 SV=2 CANONICAL=F1MIU7-1" }, "isoforms": [ { "isoform_ac": "F1MIU7-1", "url": "https://www.uniprot.org/uniprotkb/F1MIU7/entry", "sequence": { "sequence": "MASLLLLLLLLLLLPLLLLPLRIWSRLRWLAADLAFTMRALRCKRALRARALAAAAADPEGPEGGCSLAWRLAQLARQRPAHTFLIHGAQRFSYAEAERHSNRAARAFLRARGWDGGLGGGGTGGAGEGERAAHCARDQAAGSGAARAVREGDGAAPLAPGATVALLLPACPEFLWLWFGLAKAGLRTAFVPTALRRGPLQHCLRSCGARALVLAPEFLESLEPDLPALRAMGLHLWTVGSDTRPAGISDFLAEASAEVDGPVPGYLSAPQNMTDTCLYIFTSGTTGLPKAARISHLKILQCQAFYQLCGAHQEDVIYLALPLYHMSGSLLGIVGCLGIGATVVLKSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPNKAERGHKVRLVVGSGLRPDTWERFVRRFGPLQVLETYGLTEGNVATFNYTGQQGAVGRASWLYKHVFPFSLIRYDVTTGEPVRDTQGHCVATSPGEPGLLVAPVSQQSPFLGYAGGPELARGKLLKHVFQPGDVFFNTGDLLVCDNQGFLRFHDRTGDTFRWKGENVATTEVAEALEALDFLQEVNVYGVTVPGHEGRAGMAALALRPPHSLDLVQLYAHVSENLPPYARPRFLRLQESLATTETFKQQKVRMAKEGFDPSTLSDPLYILDQAGGAYLPLTPARYSALLAGDLRI", "length": 677, "header": "tr|F1MIU7-1|F1MIU7_BOVIN Isoform 1 of long-chain-fatty-acid--CoA ligase OS=Bos taurus OX=9913 GN=SLC27A3 PE=3 SV=2 CANONICAL=F1MIU7-1" }, "locus": { "chromosome": "3", "start_pos": 16623760, "end_pos": 16619384, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054019.4", "url": "https://www.ensembl.org/id/ENSBTAT00000054019.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049243.2", "url": "https://www.ensembl.org/id/ENSBTAP00000049243.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:511053", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511053", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZJA9-1", "protein_name": "long-chain-fatty-acid--CoA ligase", "gene_name": "Slc27a3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAALLLLLPLLLLLPLLLKLDLWPQLRWLRADLAFTVRALRCKRALRARALAAAAADPESPEGGCSLAWRLAHLAREQPTRTFLIYGARCFSYAEAESESNRIARAFLRARGWTAGGRGSGRGSTEEDARVAPAAGDPAAGGTTAPPLAPGATVALLLPAGPEFLWLWFGLAKAGLRTAFVPSALRRGPLLHCLRSCGASAVVLATEFLESLEPDLPALRAMGLHLWATGPGTNLAGISNLLSEAATQVDEPVPGYLSAPQNIMDTCLYIFTSGTTGLPKAARVSHLKVLQCQGFYQLCGVHQEDVIYLALPLYHMSGSLLGIVGCLGIGATVVLKPKFSASQFWEDCQRHGVTVFQYIGELCRYLVNQPPSKAECGHKVRLAVGSGLRPDTWDRFVRRFGPLQILETYGATEGNVATFNYTGQQGAVGRASWLYKHIFPFSLIRYDVMTGEPIRNAQGHCMAASPGEPGLLVAPVSQESPFLGYAGAPELAQEKLLKDVFRPGDIFFNTGDLLVCDEQGFLHFHDRTGDTFRWKGENVATTEVAEVLEALDFLQEVNIYGVTVPGHEGRAGMAALALRPPQALDLVQLYTHVSENLPPYARPRFLRLQESLATTETFKQQKVRMANEGFDPSALSDPLYVLDQDKGAYLPLTPARYNALLSGDLRI", "length": 667 }, "evidence": [ { "id": "F1MIU7", "url": "https://omabrowser.org/oma/group/F1MIU7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SFW5-1", "protein_name": "long-chain-fatty-acid--CoA ligase", "gene_name": "SLC27A3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAFLLLPLLLLLPLLLLLPKLRLWPQLRWLAADLAFTVRALRCKRVLRARALAAAAANPEGPEGGCSLAWRLAQLAQQRPAHTFLIHGARRFSYAEAESQSNRAARAFLRARGWDRGSGGGGGPRGAGESQWAAAGSGAARAGREGDGAAPLAPGATVALLLPACPEFLWLWFGLAKAGLRTAFVPTALRRGPLLHCLRSCGARALVLAAEFLESLEPDLPALRAMGLHLWAAGSETYPAGISDLLAEVSAEVDAPVPGYLSAPENIMDTCLYIFTSGTTGLPKAARISHLKVLQCQGFYQLCGARQEDVIYLALPLYHMSGSLLGIVGCLGIGATVVLKSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPNQAEHGHKVRMAVGSGLRPDTWERFVRRFGPLRVLETYGLTEGNVATFNYTGQRGAVGRASWLYKHVFPFSLIRYDVTTGEPVRNTRGHCVATSPGEPGLLVAPVSQQSPFLGYAGGPELAQGKLLKDVFRPGDIFFNTGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTEVAEALEALHFLQEVNVYGVAVPGHEGRAGMAALVLRPPHSLDLVQLYTHVSENLPPYAQPRFLRLQESLATTETFKQQKVRMAKEGFDPSTLSDPLYILDQAGGAYLPLTPARYSALLAGDLRI", "length": 672 }, "evidence": [ { "id": "F1MIU7", "url": "https://omabrowser.org/oma/group/F1MIU7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HC13-1", "protein_name": "long-chain-fatty-acid--CoA ligase", "gene_name": "Slc27a3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAVLLLLLPLLLLLPLLLKLDLWPQLRWLLADLAFTVRALRCKRALRDRALAAAAADPESPEGGCSLAWRLTHLARERPTHTFLIHGARRFSYADAERESNRAARAFLLARGWAGGRGGSGTGSTEEGAHAAASAVGDSAAGGGTTAPALVPGATVALLLPAGPEFLWLWFGLAKAGLRTAFVPTSLRRGPLLHCLRSCCASALVLAPEFLESLEPDLPAMRAMGLHLWATGPETHLAGISNFLSEAAAQVDEPVPGYLSAPQSIMDTCLYIFTSGTTGLPKAARISHLKVLQCQGFYQLCGVHQEDVIYLALPLYHMSGSLLGIVGCLGIGATVVLKPKFSASQFWEDCQKHGVTVFQYIGELCRYLVNQPPSQAEHGHKVRLAVGSGLRPDTWERFVRRFGPLQILETYGMTEGNVATFNYTGQQGAVGRASWLYKHVFPFSLIRYDVMTGEPIRNAQGHCVATSPDEPGLLVAPVSQQSPFLGYAGAPELAQGKLLKDVFRPGDVFFNTGDLLVCDKQGFLHFHDRTGDTFRWKGENVATTEVAEVLEALDFLQEVNVYGVTVPGHEGRAGMAALALRPPQALDLVQLYVHVSDNLPPYARPRFLRLQETLATTETFKQQKVRMAAEGFDPSVLSDPLYILDQDVGAYLPLTPARFNALLSGDIRI", "length": 669 }, "evidence": [ { "id": "F1MIU7", "url": "https://omabrowser.org/oma/group/F1MIU7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O88561-1", "protein_name": "Long-chain fatty acid transport protein 3", "gene_name": "Slc27a3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAALLLLLPLLLLLPLLLKLDVWPQLRWLPADLAFTVRALRCKRALRARALAAAAADPESSESGCSLAWRLAYLAREQPTHTFLIHGAQRFSYAEAERESNRIARAFLRARGWTGGRRGSGRGSTEEGARVAPPAGDAAARGTTAPPLAPGATVALLLPAGPDFLWIWFGLAKAGLRTAFVPTALRRGPLLHCLRSCGASALVLATEFLESLEPDLPALRAMGLHLWATGPETNVAGISNLLSEAADQVDEPVPGYLSAPQNIMDTCLYIFTSGTTGLPKAARISHLKVLQCQGFYHLCGVHQEDVIYLALPLYHMSGSLLGIVGCLGIGATVVLKPKFSASQFWDDCQKHRVTVFQYIGELCRYLVNQPPSKAECDHKVRLAVGSGLRPDTWERFLRRFGPLQILETYGMTEGNVATFNYTGRQGAVGRASWLYKHIFPFSLIRYDVMTGEPIRNAQGHCMTTSPGEPGLLVAPVSQQSPFLGYAGAPELAKDKLLKDVFWSGDVFFNTGDLLVCDEQGFLHFHDRTGDTIRWKGENVATTEVAEVLETLDFLQEVNIYGVTVPGHEGRAGMAALALRPPQALNLVQLYSHVSENLPPYARPRFLRLQESLATTETFKQQKVRMANEGFDPSVLSDPLYVLDQDIGAYLPLTPARYSALLSGDLRI", "length": 667 }, "evidence": [ { "id": "F1MIU7", "url": "https://omabrowser.org/oma/group/F1MIU7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5K4L6-1", "protein_name": "Long-chain fatty acid transport protein 3", "gene_name": "SLC27A3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALLLLPLLLLLPLLLLKLHLWPQLRWLPADLAFAVRALCCKRALRARALAAAAADPEGPEGGCSLAWRLAELAQQRAAHTFLIHGSRRFSYSEAERESNRAARAFLRALGWDWGPDGGDSGEGSAGEGERAAPGAGDAAAGSGAEFAGGDGAARGGGAAAPLSPGATVALLLPAGPEFLWLWFGLAKAGLRTAFVPTALRRGPLLHCLRSCGARALVLAPEFLESLEPDLPALRAMGLHLWAAGPGTHPAGISDLLAEVSAEVDGPVPGYLSSPQSITDTCLYIFTSGTTGLPKAARISHLKILQCQGFYQLCGVHQEDVIYLALPLYHMSGSLLGIVGCMGIGATVVLKSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPSKAERGHKVRLAVGSGLRPDTWERFVRRFGPLQVLETYGLTEGNVATINYTGQRGAVGRASWLYKHIFPFSLIRYDVTTGEPIRDPQGHCMATSPGEPGLLVAPVSQQSPFLGYAGGPELAQGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTEVAEVFEALDFLQEVNVYGVTVPGHEGRAGMAALVLRPPHALDLMQLYTHVSENLPPYARPRFLRLQESLATTETFKQQKVRMANEGFDPSTLSDPLYVLDQAVGAYLPLTTARYSALLAGNLRI", "length": 683 }, "evidence": [ { "id": "F1MIU7", "url": "https://omabrowser.org/oma/group/F1MIU7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "long-chain fatty acid metabolic process", "id": "GO:0001676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001676", "evidence": [ { "database": "UniProtKB", "id": "F1MIU7", "url": "https://www.uniprot.org/uniprotkb/F1MIU7" } ], "pmid": "" }, { "name": "fatty acid transport", "id": "GO:0015908", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015908", "evidence": [ { "database": "UniProtKB", "id": "F1MIU7", "url": "https://www.uniprot.org/uniprotkb/F1MIU7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1MIU7", "url": "https://www.uniprot.org/uniprotkb/F1MIU7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MIU7", "url": "https://www.uniprot.org/uniprotkb/F1MIU7" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1MIU7", "url": "https://www.uniprot.org/uniprotkb/F1MIU7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "long-chain fatty acid-CoA ligase activity", "id": "GO:0004467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004467", "evidence": [ { "database": "UniProtKB", "id": "F1MIU7", "url": "https://www.uniprot.org/uniprotkb/F1MIU7" } ], "pmid": "" }, { "name": "very long-chain fatty acid-CoA ligase activity", "id": "GO:0031957", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031957", "evidence": [ { "database": "UniProtKB", "id": "F1MIU7", "url": "https://www.uniprot.org/uniprotkb/F1MIU7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" }, { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "33639", "name": "", "equation": "tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MB67-1", "F1MIU7-1", "E1BCN4-1", "F1MQP2-1", "Q3ZKN0-1", "Q58DN7-1" ], "evidence": [ { "id": "33639", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33639" } ] }, { "id": "54536", "name": "", "equation": "a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MB67-1", "F1MIU7-1", "F1MQP2-1", "Q3ZKN0-1" ], "evidence": [ { "id": "54536", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54536" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "E1BCN4", "gene_name": "ACSBG2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "E1BCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN4" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "E1BCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN4" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "E1BCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN4" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "E1BCN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCN4" } ] } ] }, { "uniprot_ac": "F1MB67", "gene_name": "SLC27A1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MB67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB67" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "F1MB67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB67" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MB67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB67" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "F1MB67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB67" } ] } ] }, { "uniprot_ac": "F1MIU7", "gene_name": "SLC27A3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MIU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIU7" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "F1MIU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIU7" } ] } ] }, { "uniprot_ac": "F1MQP2", "gene_name": "SLC27A2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "F1MQP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQP2" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "F1MQP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQP2" } ] } ] }, { "uniprot_ac": "Q3ZKN0", "gene_name": "SLC27A1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q3ZKN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZKN0" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q3ZKN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZKN0" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q3ZKN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZKN0" } ] } ] }, { "uniprot_ac": "Q58DN7", "gene_name": "ACSF3", "activity": [ { "ec_number": "6.2.1.76", "activity": "malonate + ATP + CoA = malonyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q58DN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ] }, { "ec_number": "6.2.1.76", "activity": "", "evidence": [ { "id": "Q58DN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58DN7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MIU7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 677, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MIU7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MIU7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MIU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIU7" }, { "id": "PF13193", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13193" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "AMP-binding enzyme C-terminal", "eco_id": "ECO_0000259", "start_pos": 553, "end_pos": 629, "start_aa": "Glu", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MIU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIU7" }, { "id": "PF00501", 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"http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46756:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00307", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00307", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02187", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02187", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002687677", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687677", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MIY4", "url": "https://www.uniprot.org/uniprotkb/F1MIY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIY4-1", "url": "https://www.uniprot.org/uniprotkb/F1MIY4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTMLPAIQVWFGEDLPLSPRSPLTPRHGPGLADVCQYDEWIAVRHEATLLPMQEDLSIWLNGLLGIEVKAERLLEELDNGVLLCQLIDVLQNMVKTCNSEEPVNFPMRKVPCKKDAASGSFFARDNTANFLHWCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYGVEPPVLVKLEKEIELEETLLNTSGPEDSISIPKSCCQHEELHEAVKHIAEDPPCSCSHRFSIEYLSEGRYRLGDKILFIRMLHGKHVMVRVGGGWDTLQGFLLKYDPCRILQFATLEQKILAFQKGVSIESVPDSPARTPQPPEMNPLSAVSMFQKQNSKLGTPVGIPRGKEKQVHLPAALPSASSLKGGNLAPRSVRSKLANSPAASSHLKLMSSKGITKKPQAPSNSASSSHASLNPVGKSTFSPAFSRAAPCVSESLRKCISSPSTPKTKRVPAQKSRDVPESTILPNKCSGKTEPKHLKHNHVPSRDHAVSPSATHLNSSSKCPKLPKAHLHVRPNPSSFQSPAKVTTASSKTVIRSLETRAQPHGRAPQAQKPKSALNLNQPLPISSVAPTKAAQKLKDKNMVSVAKKQPQNKSTSQKTGTSASRSPGRTPLSIVSLPQSSAKTQPEPKSVQTATKSQCSAAGPPKSGKAPAPTRKPPSSGKETVSADEKPSAKKKEDDDHYFVMTGSKKPRK", "length": 692, "header": "tr|F1MIY4-1|F1MIY4_BOVIN Isoform 1 of Growth arrest specific 2 like 3 OS=Bos taurus OX=9913 GN=GAS2L3 PE=3 SV=3 CANONICAL=F1MIY4-1" }, "isoforms": [ { "isoform_ac": "F1MIY4-1", "url": "https://www.uniprot.org/uniprotkb/F1MIY4/entry", "sequence": { "sequence": "MTMLPAIQVWFGEDLPLSPRSPLTPRHGPGLADVCQYDEWIAVRHEATLLPMQEDLSIWLNGLLGIEVKAERLLEELDNGVLLCQLIDVLQNMVKTCNSEEPVNFPMRKVPCKKDAASGSFFARDNTANFLHWCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYGVEPPVLVKLEKEIELEETLLNTSGPEDSISIPKSCCQHEELHEAVKHIAEDPPCSCSHRFSIEYLSEGRYRLGDKILFIRMLHGKHVMVRVGGGWDTLQGFLLKYDPCRILQFATLEQKILAFQKGVSIESVPDSPARTPQPPEMNPLSAVSMFQKQNSKLGTPVGIPRGKEKQVHLPAALPSASSLKGGNLAPRSVRSKLANSPAASSHLKLMSSKGITKKPQAPSNSASSSHASLNPVGKSTFSPAFSRAAPCVSESLRKCISSPSTPKTKRVPAQKSRDVPESTILPNKCSGKTEPKHLKHNHVPSRDHAVSPSATHLNSSSKCPKLPKAHLHVRPNPSSFQSPAKVTTASSKTVIRSLETRAQPHGRAPQAQKPKSALNLNQPLPISSVAPTKAAQKLKDKNMVSVAKKQPQNKSTSQKTGTSASRSPGRTPLSIVSLPQSSAKTQPEPKSVQTATKSQCSAAGPPKSGKAPAPTRKPPSSGKETVSADEKPSAKKKEDDDHYFVMTGSKKPRK", "length": 692, "header": "tr|F1MIY4-1|F1MIY4_BOVIN Isoform 1 of Growth arrest specific 2 like 3 OS=Bos taurus OX=9913 GN=GAS2L3 PE=3 SV=3 CANONICAL=F1MIY4-1" }, "locus": { "chromosome": "5", "start_pos": 64516035, "end_pos": 64496060, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018363.8", "url": "https://www.ensembl.org/id/ENSBTAT00000018363.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018363.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018363.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:782903", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782903", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AL26-1", "protein_name": "Growth arrest-specific 2 like 3", "gene_name": "Gas2l3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTMQPAIQVWFGEDLPLSPRCPLTSRHGPGLADVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIDIKAERLLEELDNGVLLCQLINVLQNMVGAGLSEEPGNFPMRKVPCKKDAASGSFFARDNTANFLHWCRRIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRVVSRYGVEPPVLVKLEKEIELEETLLNTSGLEESISIPKSCCQQEELHEAVKHIAEDPPCSCSHRFSIEYLSEGRYRLGEKILFIRMLHGKHVMVRVGGGWDTLQGFLLKYDPCRILQFATLEQKILAFQKGVSNESVPDSPARTPQPPEMNPLSAVNMFQKQNLKPGTPVSVPKGKERQVHRPGACLPASSVKGNLASLSTRSKRPDSPASLLHPKVTSLKGIAKKVNAPSNSALSSLTSLNPAAKPSTAKCASESGRKCVTFPKTPQTKAVPAQNSRDPSKSRLLPSKPPGNIEPKHLKHNHLSSRAESSTCPKLPKGTMQGRPNLSPFQSPAKVTKPSSKTRAIGLGTQSQPPDRTLKSGATSAPRHQSTLNLNNPASVCSGSSANTTQKLKGKSTVSVAKKPPQSKGICPNLGPSSSKSPGRTPLSIVTVPQSAAKSETVSKSAKTAMKGQYSAKGPPKSSKAPASSQNPPSSGKGADSGNKTPTAKKKEEDDHYFVMTGNKKLRK", "length": 678 }, "evidence": [ { "id": "F1MIY4", "url": "https://omabrowser.org/oma/group/F1MIY4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3UWW6-1", "protein_name": "GAS2-like protein 3", "gene_name": "Gas2l3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTMQPAIQVWFGEDLPLSPRCPLTPRHGPGLADVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGVDIKAERLLEELDNGVLLCQLINVLQNMVKGCHSDEPGNFPMRKVPCKKDAASGSFFARDNTANFLHWCRHIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYGVEPPVLVKLEKEIELEETLLNASGLEESISIPKSCCQQEELHEAVKHIAEDPPCSCSHRFSIEYLSEGRYRLGEKILFIRMLHGKHVMVRVGGGWDTLQGFLLKYDPCRILQFATLEQKILAFQKGVSNESVPDSPARTPKPPEMNPLSAVNMFQKQNLRPGTPVSVPKNKEKQVRLPGARLPASSVKGNLASPSTRAKRPDSPASFPHPKVTSLKDAAKKTTAPSNSVSQSLASPNPGSKPSTAQCASESSRKCVTFPKTAQTKAIPAQNSRDLSKSRLLPSKSPGKMEPKHLKHNHLSSRDESRINLSSKSPKLPKGAMHGRPNPSPFQPPAKVTKPSSKTGAIGLGTQSQPPTRTPRSGAVSAQRLQSTLNLNSPASVCSGSSAKATQGSKGKNTVSVAKKQPQSKGVCRNPGPGSSKSPGRTPLSIVTVPQSATKTETVSKSAKTAMKGQYSAKGPPKSSKPPTSFRDPPSSGKGADSGDKMPTARKKEEDDHYFVMTGNKKLRK", "length": 683 }, "evidence": [ { "id": "F1MIY4", "url": "https://omabrowser.org/oma/group/F1MIY4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86XJ1-1", "protein_name": "GAS2-like protein 3", "gene_name": "GAS2L3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQPAIQVWFGEDLPLSPRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQNMVKTCNSEESGNFPMRKVPCKKDAASGSFFARDNTANFLHWCRDIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYGVEPPVLVKLEKEIELEETLLNTSGPEDSISIPKSCCRHEELHEAVKHIAEDPPCSCSHRFSIEYLSEGRYRLGDKILFIRMLHGKHVMVRVGGGWDTLQGFLLKYDPCRILQFATLEQKILAFQKGVSNESVPDSPARTPQPPEMNPLSAVNMFQKQNSKPSVPVSIPKSKEKQGRPPGALVPASSLKGGNLGSMSVRSKLPNSPAASSHPKLKSSKGITKKPQAPSNNASSSLASLNPVGKNTSSPALPRTAPCISESPRKCISSPNTPKAKVIPAQNSADLPESTLLPNKCSGKTQPKYLKHNHISSRDNAVSHLAAHSNSSSKCPKLPKANIPVRPKPSFQSSAKMTKTSSKTIATGLGTQSQPSDGAPQAKPVPAQKLKSALNLNQPVSVSSVSPVKATQKSKDKNIVSATKKQPQNKSAFQKTGPSSLKSPGRTPLSIVSLPQSSTKTQTAPKSAQTVAKSQHSTKGPPRSGKTPASIRKPPSSVKDADSGDKKPTAKKKEDDDHYFVMTGSKKPRK", "length": 694 }, "evidence": [ { "id": "F1MIY4", "url": "https://omabrowser.org/oma/group/F1MIY4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GGB8-1", "protein_name": "Growth arrest specific 2 like 3", "gene_name": "GAS2L3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQVTMQNAVQVWFGDDLPLCPRSPLTPRHGPGLADVCLYDQWISVRHEATLVPMQEDLSIWLSGLLGIEVTAEQLLEELDNGVLLCQLIGVLQNTIKKSCSSNNLRNFPMRKVPCKKDAPSGSFFARDNTANFLNWCRAIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYGVEPPVLVKLEKEIELEETLLRTSGPASPVNTAKSCCQHGELHEAVKHIAEDPPCSCSHRFSIEYLSEGRYRLGDKILFIRMLHGKHVMVRVGGGWDTLQGFLLKYDPCRVLQFATLEQKILAFQKGVTSDNISNSPARIQEPPVMNPMSAVNMFQKQPANPPTPVPALKAIHGATAKKPLSKHPQSPALTSPKVPVHASSTAKLLSARPKLTDAQSPFKPLTGTSKKLASPACHSPAPVPSLPASKSSSSTRSRTALVHSETLRKRIRSPDAPKVRFAPAQGSPATGMHSALSASKKQLSQLPATAETLASKQKCVPSKSKPASVTKTKANAVAPRPARLPVTNLRAVAKFAHSQQLYVKPPSENTTQASGSGSQHPRKAPQTASDLARNMKTGSILKHSASVPSLAVSKALKSPPMLGSTSKNVTASVKKTPTTEHLQTPNVNKPPEVGPSSSKTPERTPLSVVRLPQTSAKVAVTKKAVQPSTKSQPSNRDLQANGNMVPAAKKPLSKGKSPTACNKGAPSASKGPLLKSKQDDHYFVMTGSKKPRK", "length": 726 }, "evidence": [ { "id": "F1MIY4", "url": "https://omabrowser.org/oma/group/F1MIY4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "F1MIY4", "url": "https://www.uniprot.org/uniprotkb/F1MIY4" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "F1MIY4", "url": "https://www.uniprot.org/uniprotkb/F1MIY4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "F1MIY4", "url": "https://www.uniprot.org/uniprotkb/F1MIY4" } ], "pmid": "" }, { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "F1MIY4", "url": "https://www.uniprot.org/uniprotkb/F1MIY4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "F1MIY4", "url": "https://www.uniprot.org/uniprotkb/F1MIY4" } ], "pmid": "" }, { "name": "actin crosslink formation", "id": "GO:0051764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051764", "evidence": [ { "database": "UniProtKB", "id": "F1MIY4", "url": "https://www.uniprot.org/uniprotkb/F1MIY4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 496, "end_pos": 498, "annotation": "n_glycosylation_sequon" }, { "start_pos": 591, "end_pos": 593, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MIY4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 692, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MIY4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MIY4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 195, "end_pos": 197 }, { "start_pos": 496, "end_pos": 498 }, { "start_pos": 591, "end_pos": 593 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MIZ2-1", "uniprot_ac": "F1MIZ2", "uniprot_id": "F1MIZ2_BOVIN", "mass": { "chemical_mass": 46367.0, "monoisotopic_mass": 46367.0 }, "refseq": {}, "gene_names": [ { "name": "PLEKHO1", "type": "recommended", "evidence": [ { "id": "F1MIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIZ2" } ] } ], "protein_names": [ { "name": "Pleckstrin homology domain-containing family O member 1", "type": "recommended", "evidence": [ { "id": "F1MIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIZ2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MIZ2", "url": "https://www.uniprot.org/uniprotkb/F1MIZ2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLEKHO1", "url": "https://www.uniprot.org/uniprotkb/F1MIZ2", "locus": { "chromosome": "3", "start_pos": 20476039, "end_pos": 20485097, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004852", "url": "https://www.ensembl.org/id/ENSBTAG00000004852" } ] } } ], "crossref": [ { "id": "F1MIZ2", "url": "https://alphafold.ebi.ac.uk/entry/F1MIZ2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004852", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004852", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13317", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13317", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "VQPEKVG", "url": "https://omabrowser.org/oma/group/VQPEKVG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MIZ2", "url": "https://www.orthodb.org/?gene=F1MIZ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15871", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15871", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15871:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15871:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MIZ2", "url": "https://www.uniprot.org/uniprotkb/F1MIZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MIZ2-1", "url": "https://www.uniprot.org/uniprotkb/F1MIZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMKKNNSTKRGPQDGNHQCAPPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRVLDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSSDRASGLPRLWEKPDKGATYTPQAPKKLTATEKSRCASLEEILSQRDAVPAHTLQQRAEDPPTPIPHAPGQLSRIQDLVARKLEKTQELLAEVQGLGDGKRKAKEPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTQHSQYRKSLM", "length": 409, "header": "tr|F1MIZ2-1|F1MIZ2_BOVIN Isoform 1 of Pleckstrin homology domain-containing family O member 1 OS=Bos taurus OX=9913 GN=PLEKHO1 PE=4 SV=1 CANONICAL=F1MIZ2-1" }, "isoforms": [ { "isoform_ac": "F1MIZ2-1", "url": "https://www.uniprot.org/uniprotkb/F1MIZ2/entry", "sequence": { "sequence": "MMKKNNSTKRGPQDGNHQCAPPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRVLDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSSDRASGLPRLWEKPDKGATYTPQAPKKLTATEKSRCASLEEILSQRDAVPAHTLQQRAEDPPTPIPHAPGQLSRIQDLVARKLEKTQELLAEVQGLGDGKRKAKEPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTQHSQYRKSLM", "length": 409, "header": "tr|F1MIZ2-1|F1MIZ2_BOVIN Isoform 1 of Pleckstrin homology domain-containing family O member 1 OS=Bos taurus OX=9913 GN=PLEKHO1 PE=4 SV=1 CANONICAL=F1MIZ2-1" }, "locus": { "chromosome": "3", "start_pos": 20484994, "end_pos": 20476132, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006381.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006381.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006381.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006381.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F1SS76-1", "protein_name": "Pleckstrin homology domain-containing family O member 1", "gene_name": "PLEKHO1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMKKNNSTKRGPQDGNHQSAPPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEESTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRAGGLPRRWEKPDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAAPARALQLQAEDPPTPIPPHPGQLSRIQDLVARKLEKTQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTQHSQYRKSLM", "length": 409 }, "evidence": [ { "id": "F1MIZ2", "url": "https://omabrowser.org/oma/group/F1MIZ2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q53GL0-1", "protein_name": "Pleckstrin homology domain-containing family O member 1", "gene_name": "PLEKHO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMKKNNSAKRGPQDGNQQPAPPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRKSLM", "length": 409 }, "evidence": [ { "id": "F1MIZ2", "url": "https://omabrowser.org/oma/group/F1MIZ2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JIY0-1", "protein_name": "Pleckstrin homology domain-containing family O member 1", "gene_name": "Plekho1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKKSGSGKRGPPDGNHQSAAPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYVSEKEVKDEKNSQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLARCRQPGTTAPNLIFLAVSPEEKESWINALSSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPASCAESFRVDLDKSVAQLAGSRRRADSDRIQPSSQRASSLSRPWEKPDKGAPYTPQALKKFPSTEKSRCASLEEILSQRDTAPARPLHLQAEESLPPVPAQPGQLSRIQDLVARKLEKTQELLAEVQGLGDGKRKAKDPPQSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTSQHSQYRKSLM", "length": 408 }, "evidence": [ { "id": "F1MIZ2", "url": "https://omabrowser.org/oma/group/F1MIZ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MIZ2", "url": "https://www.uniprot.org/uniprotkb/F1MIZ2" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1MIZ2", "url": "https://www.uniprot.org/uniprotkb/F1MIZ2" } ], "pmid": "" }, { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "F1MIZ2", "url": "https://www.uniprot.org/uniprotkb/F1MIZ2" } ], "pmid": "" }, { "name": "muscle cell projection membrane", "id": "GO:0036195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036195", "evidence": [ { "database": "UniProtKB", "id": "F1MIZ2", "url": "https://www.uniprot.org/uniprotkb/F1MIZ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of myoblast fusion", "id": "GO:1901739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901739", "evidence": [ { "database": "UniProtKB", "id": "F1MIZ2", "url": "https://www.uniprot.org/uniprotkb/F1MIZ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 365, "end_pos": 367, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 6, "end_pos": 8, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MIZ2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 409, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MIZ2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MIZ2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MIZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIZ2" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 21, "end_pos": 132, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 365, "end_pos": 367 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 6, "end_pos": 8 }, { "start_pos": 91, "end_pos": 93 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJ04-1", "uniprot_ac": "F1MJ04", "uniprot_id": "F1MJ04_BOVIN", "mass": { "chemical_mass": 125848.0, "monoisotopic_mass": 125848.0 }, "refseq": {}, "gene_names": [ { "name": "PCDH18", "type": "recommended", "evidence": [ { "id": "F1MJ04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ04" } ] } ], "protein_names": [ { "name": "Protocadherin 18", "type": "synonym", "evidence": [ { "id": "F1MJ04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ04/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Potential calcium-dependent cell-adhesion protein.", "evidence": [ { "database": "UniProtKB", "id": "F1MJ04", "url": "https://www.uniprot.org/uniprotkb/F1MJ04#function" }, { "database": "UniProtKB", "id": "ARBA00037723", "url": "https://www.uniprot.org/uniprotkb/ARBA00037723#function" }, { "database": "UniProtKB", "id": "A0ABI0NUP5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUP5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJ04", "url": "https://www.uniprot.org/uniprotkb/F1MJ04" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCDH18", "url": "https://www.uniprot.org/uniprotkb/F1MJ04", "locus": { "chromosome": "17", "start_pos": 20302085, "end_pos": 20288045, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015549", "url": "https://www.ensembl.org/id/ENSBTAG00000015549" } ] } } ], "crossref": [ { "id": "F1MJ04", "url": "https://alphafold.ebi.ac.uk/entry/F1MJ04", "database": "AlphaFoldDB", "categories": [] }, { "id": "cd11304", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11304", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002126", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002126", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015919", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015919", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050174", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050174", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PHTEWEL", "url": "https://omabrowser.org/oma/group/PHTEWEL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MJ04", "url": "https://www.orthodb.org/?gene=F1MJ04", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0ABI0NUP5", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NUP5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUP5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ04", "url": "https://www.uniprot.org/uniprotkb/F1MJ04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ04-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ04-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYQMNAKMHFTFVFALLVVSFNLDVLGKNLKYRIYEEQRVGSVIARLSEDVADVLVKLPNPSTVRFRAMQRGNTPLLVVNEDNGEISIGAKIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIIETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEISINLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDKGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFAISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEISIPKGAESGFHVTRIRAIDRDSGVNAELSCSIVAGNEENIFVIDPRSCDIHTNVSMESVPYTEWELSVVIQDKGNPQLHTKVLLKCVIFEYAESVTSTAMTSVSQAPLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTVNGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPAQPQQQHPHQSLEDDVQPVDSGEKKKSFSTFGKDSPSEEDSGDTSTSSLLSEMSSVFQRLLPASLDTYSECTEMDRSNSLERRKGPLPAKTVGYPQGVAAWAASTHFQNPTNNSGPPLGTHSSVQPSSKWLPAMEEIPENYEEDDFDNVLNHLNDGKHELMDASELVAEINKLLQDVRQS", "length": 1134, "header": "tr|F1MJ04-1|F1MJ04_BOVIN Isoform 1 of Protocadherin 18 OS=Bos taurus OX=9913 GN=PCDH18 PE=4 SV=2 CANONICAL=F1MJ04-1" }, "isoforms": [ { "isoform_ac": "A0ABI0NUP5-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NUP5/entry", "sequence": { "sequence": "MQGLDSMPVISGRRDTNLKYRIYEEQRVGSVIARLSEDVADVLVKLPNPSTVRFRAMQRGNTPLLVVNEDNGEISIGAKIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIIETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEISINLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDKGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFAISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEISIPKGAESGFHVTRIRAIDRDSGVNAELSCSIVAGNEENIFVIDPRSCDIHTNVSMESVPYTEWELSVVIQDKGNPQLHTKVLLKCVIFEYAESVTSTAMTSVSQAPLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTVNGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPAQPQQQHPHQSLEDDVQPVDSGEKKKSFSTFGKDSPSEEDSGDTSTSSLLSEMSSVFQRLLPASLDTYSECTEMDRSNSLERRKGPLPAKTVGYPQGVAAWAASTHFQNPTNNSGPPLGTHSSVQPSSKWLPAMEEIPENYEEDDFDNVLNHLNDGKHELMDASELVAEINKLLQDVRQS", "length": 1122, "header": "tr|A0ABI0NUP5-1|A0ABI0NUP5_BOVIN Computationally mapped isoform of Protocadherin 18 OS=Bos taurus OX=9913 GN=PCDH18 PE=4 SV=1 CANONICAL=F1MJ04-1" }, "locus": { "chromosome": "17", "start_pos": 20300800, "end_pos": 20288203, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154317.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154317.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107454.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107454.1" } ] } }, { "isoform_ac": "F1MJ04-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ04/entry", "sequence": { "sequence": "MYQMNAKMHFTFVFALLVVSFNLDVLGKNLKYRIYEEQRVGSVIARLSEDVADVLVKLPNPSTVRFRAMQRGNTPLLVVNEDNGEISIGAKIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIIETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEISINLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDKGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFAISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEISIPKGAESGFHVTRIRAIDRDSGVNAELSCSIVAGNEENIFVIDPRSCDIHTNVSMESVPYTEWELSVVIQDKGNPQLHTKVLLKCVIFEYAESVTSTAMTSVSQAPLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTVNGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPAQPQQQHPHQSLEDDVQPVDSGEKKKSFSTFGKDSPSEEDSGDTSTSSLLSEMSSVFQRLLPASLDTYSECTEMDRSNSLERRKGPLPAKTVGYPQGVAAWAASTHFQNPTNNSGPPLGTHSSVQPSSKWLPAMEEIPENYEEDDFDNVLNHLNDGKHELMDASELVAEINKLLQDVRQS", "length": 1134, "header": "tr|F1MJ04-1|F1MJ04_BOVIN Isoform 1 of Protocadherin 18 OS=Bos taurus OX=9913 GN=PCDH18 PE=4 SV=2 CANONICAL=F1MJ04-1" }, "locus": { "chromosome": "17", "start_pos": 20300800, "end_pos": 20288422, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020655.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020655.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020655.4", "url": "https://www.ensembl.org/id/ENSBTAP00000020655.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287A1I6-1", "protein_name": "Protocadherin 18", "gene_name": "PCDH18", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MYQMNAKMHFRFVFALLVVSFNSDALGKNLKYRIYEEQRVGSVIARLSEDVADVLVKLPNPLTVRFRAMQRGNSPLLVVNEDNGEISIGAKIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELRLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIIETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEININFMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGPNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDKGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFAISENNSPGAYITTVTATDPDLGENGQVTYTVLESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEISIPKGAESGFHVTRIRAIDRDSGVNAELSCSIIAGNEENIFVMDPRSCDIHTNVSMESVPYTEWELSIVIQDKGNPQLHTKVLLKCMIFEYAESVTSTAMTSVSQASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTVNGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPAQPQQQHPHQSLEDDTQPADSSEKKKSFSTFGKDSPNDEDSGDTSTSSLLSEMSSVFQRLLPPSLDTYAECSEMDRSNSLERRKGPLPAKTVGYPQGVAAWAASTHFQNPANNSGPPLGTHSSVQPSSKWLPAMEEIPENYEEDDFDNVLNHLNDGKHELMDASELVAEINKLLQDVRQS", "length": 1134 }, "evidence": [ { "id": "F1MJ04", "url": "https://omabrowser.org/oma/group/F1MJ04/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2QMM5-1", "protein_name": "Protocadherin-18 isoform X2", "gene_name": "Pcdh18", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MHQMNTKMHFRFALALLMAFFSHDVLGKNLKYRIYEEQRVGSVIARLSEDVADVLLKLPNPSAVRFRAMPRGNSPLLVVNENTGEISIGAKIDREQLCQKNLNCSIEFDVLTLPTEHLQLFHIEVDVLDINDNSPQFSRPVIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKASYELQLTASDMGVPQRSGSSVLKISISDSNDNSPAFEQPSYTIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIIETFKIDSERGHLTLFKPVDYEVTKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEISINLMSPGKEEVSYVFEGDPIDTFVAIVRVQDKDSGLNGEIICKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDKGTPSLSSVKHFTVQINDINDNPPRFQRSRYEFVISENNSPGAYITTVTATDPDLGENGHVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSQKQLASNTTVVLTIIDENDNNPVVIGPAMHNNTAEISIPKGAESGFHVTRIRAIDRDSGANAELSCSIVAGNEENIFILDPKSCDIHTNVSMESIPSTEWALSVIIQDKGNPPLHTKVLLKCMIFDYAESVTSTAMTSVSHASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPAQPQQQLSHQGLDDDSQPAESGEKKKSFSTFGKDSPSDEDSGDSSTSSLLSEMSSVFQRLLPASLDTYSECSEGDRSNSLERRKGPVQAKTGGYPQGVAAWAASTHFQNPTNSSGTPLGTHSSVQPSSKWLPAMEEIPENYEEDDFDNVLNHLSDGKHELMDASELVAEINKLLQDVRQS", "length": 1134 }, "evidence": [ { "id": "F1MJ04", "url": "https://omabrowser.org/oma/group/F1MJ04/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0Y103-1", "protein_name": "Protocadherin 18", "gene_name": "PCDH18", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNCRNLQTRQAGSKMHFLFLFALAVASLDKAVLGKNLKYRIYEEQQVGLVIARLAEDVADVLLKIPNPASVRFRAMQRGNSPLLVVREDNGEISIGAKIDREQLCQKNLNCSIEFDVITLPTDHLQLFHVEVEVLDINDNSPQFARALIPIEISESAAVGTRIPLDSAFDPDVGDNSLHTYSLSDNDFFSIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDKGVPQKSGSSLLKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLIDLNATDPDEGANGKVVYSFSSHVSPKIMETFRIDSEKGHLTLLKQVDYEITKSYEIDAQAQDMGPNSIPAHCKIIIKIVDVNDNRPEISLNLMSPEKEETAYISEGSPLDTFVALVRVQDKDSGVNGEVVCKLHGHGHFKLQKTYENNYLILTNASLDREKRSEYSLTVIAEDKGTPSLSTVKHFTVQISDENDNPPRFQTNRYEVVILENNSPGAYITSVTATDPDLGDNGQVTYTILETSVLGSSITTYVTIDPSNGAIYALRTFDHEEVNQIVFMVQARDGGSQQLVSNTTVVLTIIDENDNAPVIVGPALHNSTAEISIPKDAGIGFLVTRIRATDRDSGMNSELSCSIAADKENSIFVMDPKTCDISINVSVESVPAKHWEFYVIVQDKGSPQLSTKALLKCTVFEYVYSFSSTEATLVSQPSLDVSMITIISLGSICAVLLVIMVIFATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTVNGTLPIRSHHRASPSSSPTLERGQMSSRQSHHSHQSLNSLVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRESPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFQSQQQQLQQQQQQGLEEDPQPADTSEKKKSFSTFGKDCQGEEESGDTCTSSLLSEMSSVFQRLLPPSLDAYTECNEMDRLNSLERRKGHLPAKAVNYPQGVAAWAASTHFQNPANNGPTLGTHSSAQPSSKWLPAMEEIPENYEEDDFDNVLNHLSDGKHELMDASELVAEINKLLQDVRQN", "length": 1142 }, "evidence": [ { "id": "F1MJ04", "url": "https://omabrowser.org/oma/group/F1MJ04/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q9HCL0-1", "protein_name": "Protocadherin-18", "gene_name": "PCDH18", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHQMNAKMHFRFVFALLIVSFNHDVLGKNLKYRIYEEQRVGSVIARLSEDVADVLLKLPNPSTVRFRAMQRGNSPLLVVNEDNGEISIGATIDREQLCQKNLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLSANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGNEENIFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQDKGNPQLHTKVLLKCMIFEYAESVTSTAMTSVSQASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDTRSYNCRVAESTYQHHPKRPSRQIHKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLTDGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPTQPQQQHPHQSLEDDAQPADSGEKKKSFSTFGKDSPNDEDTGDTSTSSLLSEMSSVFQRLLPPSLDTYSECSEVDRSNSLERRKGPLPAKTVGYPQGVAAWAASTHFQNPTTNCGPPLGTHSSVQPSSKWLPAMEEIPENYEEDDFDNVLNHLNDGKHELMDASELVAEINKLLQDVRQS", "length": 1135 }, "evidence": [ { "id": "F1MJ04", "url": "https://omabrowser.org/oma/group/F1MJ04/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MJ04", "url": "https://www.uniprot.org/uniprotkb/F1MJ04" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1MJ04", "url": "https://www.uniprot.org/uniprotkb/F1MJ04" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "F1MJ04", "url": "https://www.uniprot.org/uniprotkb/F1MJ04" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "F1MJ04", "url": "https://www.uniprot.org/uniprotkb/F1MJ04" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MJ04", "url": "https://www.uniprot.org/uniprotkb/F1MJ04" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "F1MJ04", "url": "https://www.uniprot.org/uniprotkb/F1MJ04" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1066, "end_pos": 1068, "annotation": "n_glycosylation_sequon" }, { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 420, "end_pos": 422, "annotation": "n_glycosylation_sequon" }, { "start_pos": 477, "end_pos": 479, "annotation": "n_glycosylation_sequon" }, { "start_pos": 559, "end_pos": 561, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" }, { "start_pos": 641, "end_pos": 643, "annotation": "n_glycosylation_sequon" }, { "start_pos": 766, "end_pos": 768, "annotation": "n_glycosylation_sequon" }, { "start_pos": 816, "end_pos": 818, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJ04-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1134, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJ04-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJ04" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJ04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ04" }, { "id": "PS50268", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cadherin", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 137, "start_aa": "Leu", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 }, { "start_pos": 1066, "end_pos": 1068 }, { "start_pos": 269, "end_pos": 271 }, { "start_pos": 420, "end_pos": 422 }, { "start_pos": 477, "end_pos": 479 }, { "start_pos": 559, "end_pos": 561 }, { "start_pos": 583, "end_pos": 585 }, { "start_pos": 641, "end_pos": 643 }, { "start_pos": 766, "end_pos": 768 }, { "start_pos": 816, "end_pos": 818 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJ19-1", "uniprot_ac": "F1MJ19", "uniprot_id": "F1MJ19_BOVIN", "mass": { "chemical_mass": 80244.0, "monoisotopic_mass": 80244.0 }, "refseq": { "ac": "XP_005214854", "name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214854" }, "gene_names": [ { "name": "PCIF1", "type": "recommended", "evidence": [ { "id": "F1MJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ19" } ] }, { "name": "PCIF1", "type": "synonym", "evidence": [ { "id": "XP_005214854", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214854" } ] } ], "protein_names": [ { "name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase", "type": "recommended", "evidence": [ { "id": "F1MJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ19/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.62", "type": "synonym", "evidence": [ { "id": "F1MJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ19/entry#names_and_taxonomy" } ] }, { "name": "Cap-specific adenosine methyltransferase", "type": "synonym", "evidence": [ { "id": "F1MJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ19/entry#names_and_taxonomy" } ] }, { "name": "Phosphorylated CTD-interacting factor 1", "type": "synonym", "evidence": [ { "id": "F1MJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ19/entry#names_and_taxonomy" } ] }, { "name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005214854", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214854" } ] } ], "function": [ { "annotation": "Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs. Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally.", "evidence": [ { "database": "UniProtKB", "id": "F1MJ19", "url": "https://www.uniprot.org/uniprotkb/F1MJ19#function" }, { "database": "UniProtKB", "id": "ARBA00055394", "url": "https://www.uniprot.org/uniprotkb/ARBA00055394#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJ19", "url": "https://www.uniprot.org/uniprotkb/F1MJ19" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PCIF1", "url": "https://www.uniprot.org/uniprotkb/F1MJ19", "locus": { "chromosome": "13", "start_pos": 74698048, "end_pos": 74686117, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010126", "url": "https://www.ensembl.org/id/ENSBTAG00000010126" } ] } } ], "crossref": [ { "id": "F1MJ19", "url": "https://alphafold.ebi.ac.uk/entry/F1MJ19", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010126", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010126", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535479", "url": "https://www.ncbi.nlm.nih.gov/gene/535479", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ANENHRS", "url": "https://omabrowser.org/oma/group/ANENHRS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR21727", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21727", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21727:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21727:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00397", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00397", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12237", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12237", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005214854", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214854", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MJ19", "url": "https://www.uniprot.org/uniprotkb/F1MJ19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ19-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ19-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MANENHGSPREEASLLSHSPGTSSQSQPCSPKPIRLVQDLPEELVHAGWEKCWSRRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNATPLPQDSSLVETPLAENKPRKRQLSEEQPSGNGVKKPKIEIPMTPTGPSVPSSPSIPGTPTLKIWGTSPEDKQQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGSDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKDHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAILKENNIPEEVEAPEVEPRLVYCYPVRLAVPAPPMPSVEMHVENSVVCVRYKGEMVKVSRNYFSKLWLLYRYSCIDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFSPLSGSFEANPPFCEELMDAMVSHFEKLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLVLPAFEHEYRSGSQHVCKKEEMHYKAVHNTAVLFLQNEPGFAKWGPTPERLQELSAACRQSGRSHGSSGSASSEAKDRDSGRDQGPSREPHST", "length": 702, "header": "tr|F1MJ19-1|F1MJ19_BOVIN Isoform 1 of mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase OS=Bos taurus OX=9913 GN=PCIF1 PE=3 SV=2 CANONICAL=F1MJ19-1" }, "isoforms": [ { "isoform_ac": "F1MJ19-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ19/entry", "sequence": { "sequence": "MANENHGSPREEASLLSHSPGTSSQSQPCSPKPIRLVQDLPEELVHAGWEKCWSRRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNATPLPQDSSLVETPLAENKPRKRQLSEEQPSGNGVKKPKIEIPMTPTGPSVPSSPSIPGTPTLKIWGTSPEDKQQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGSDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKDHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAILKENNIPEEVEAPEVEPRLVYCYPVRLAVPAPPMPSVEMHVENSVVCVRYKGEMVKVSRNYFSKLWLLYRYSCIDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFSPLSGSFEANPPFCEELMDAMVSHFEKLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLVLPAFEHEYRSGSQHVCKKEEMHYKAVHNTAVLFLQNEPGFAKWGPTPERLQELSAACRQSGRSHGSSGSASSEAKDRDSGRDQGPSREPHST", "length": 702, "header": "tr|F1MJ19-1|F1MJ19_BOVIN Isoform 1 of mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase OS=Bos taurus OX=9913 GN=PCIF1 PE=3 SV=2 CANONICAL=F1MJ19-1" }, "locus": { "chromosome": "13", "start_pos": 74697044, "end_pos": 74689534, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013362.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013362.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013362.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013362.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 593, "start_aa": "Thr", "end_pos": 593, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr593", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 656, "start_aa": "Thr", "end_pos": 656, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr656", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4IKJ1-1", "protein_name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase", "gene_name": "pcif1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTSENHTTIKADSALVMSPTGSTSQAAPFSPSTSKPIQELPDELIQAGWSKCWSKRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNAAPASGEANADAGLGNGQRKRHPSEDASQAGPNSFKRPKVEIPATPTTPTVPISPSTPGVKPWVNTTTDEKQGQASTPAPAPYRPSVVYWDLDIQTNAVIRERAPADHLPPHPEIELQRAQLTTKLRQHYHELCSQREGIEPPRESFNRWLLERKVVDKGLDPLLPSECDPVISPSMFREIMNDIPIRLSRIKYKEEARKLLFKYAEAAKKMIDSRNATPESRKVVKWNVEDTMNWLRRDHSASKEDYMDRLEHLRKQCGPHVASVAKDSVEGICSKIYHISAEYVRRIRQAHLTLLKECNISVDGTESAEVQDRLVYCYPVRLSIPAPPQTRVELHFENDIACLRFKGEMVKVSRGHFNKLELLYRYSCIDDPRFEKFLSRVWCLIKRYQVMFGSGVNEGSGLQGSLPVPVFEALNKQFGVTFECFASPLNCYFKQFCSAFPDIDGFFGSRGPFLSFSPASGSFEANPPFCEELMDAMVTHFEDLLGRSSEPLSFIIFVPEWRDPPTPALTRMEASRFRRHQMTVPAFEHEYRSGSQHICKREEIYYKAIHGTAVIFLQNNAGFAKWEPTTERIQELLAAYKVSGRSLPSPGPSSTNTGEKDSKPAPERTAPSQDNSSPVDKTAQDTTNT", "length": 721 }, "evidence": [ { "id": "F1MJ19", "url": "https://omabrowser.org/oma/group/F1MJ19/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0YWB0-1", "protein_name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase", "gene_name": "PCIF1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MANENHGSPAEEASLMSHSPGTSNQNQPSSPKPMRLVQDLPDELVQAGWEKCWSKRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNAAPMPLESGMVETSVESKQRKRRFSEEVPPSGNSVKKPKSDIPGNPAAQPVPSSPSIPGSSVLKAWCVSPEDKQQAALLRPTEVYWDLDIQTNAVIKQRAPSEVLSPHPEVELLRSQLILKLRQHYRELCQQREGIDPPRESFNRWMLERKVVDKGTDPLLPSDCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAAKRLIESRSASPDSRKVVKWNVEDTFSWLRRDHSASKEDYMDRLEHLRKQCGPHVSAAAKDSVEGICSKIYYISLEYVKRIREKHLAILKENNISAEVEAPEVQDRLVYCYPVRLAIPSPPLPSVEMHMENNVACVRYKGEMVKVSRNYFSKLWLLYRYSCIDDSGFEKFLPRVWCLLRRYQMMFGVGLYEGTGLQGALPVHVFEALHKLFGVSFECFASPLNCYFKQYCSAFLDTDGYFGSRGPCLDFFPISGSFEANPPFCEELMDAMVSHFEKLLESSSEPLSFIVFIPEWRDPPTPALTRMEQSKFKRHQLILSAFDHEYRSGSQHVCKKEEMYYKAVHNTAVLFLQNSAGFAKWEPTPERLQELVAAYKHSGRTLSSSSSSSSSSTSSTDKERELGREQSSSRETNAN", "length": 707 }, "evidence": [ { "id": "F1MJ19", "url": "https://omabrowser.org/oma/group/F1MJ19/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0LF07-1", "protein_name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase", "gene_name": "Pcif1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MANENHGSPREEASLLSHSPGTSNQNQPCSPKPVRLVQDLPEELVHAGWEKCWSRRESRPYYFNRFTNQSLWEMPVLGQHDVLSDPLGLNATPLPQDSTLVETPPVENKPRKRQLSEEQPSGNGVKKPKIEIPVTPTSQSVPSSPSIPGTPILKIWGASTEDKQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGCDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKEHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAILKENNIPEEVEASELEPRLVYCYPVRLAVSAPPMPSVEMHMENSVVCIRYKGEMVKVSRSYFSKLWLLYRYSCVDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFTPLSGSFEANPPFCEELMDAMVSHFEKLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLVLSAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNDPGFAKWGPTPERLQELTAAYKQSGRSHGSSSSSSSSSSEAKDRDSGREQGPSREPHPT", "length": 704 }, "evidence": [ { "id": "F1MJ19", "url": "https://omabrowser.org/oma/group/F1MJ19/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SC59-1", "protein_name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase", "gene_name": "PCIF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MANENHGSPREEASLLSHSPGTSNQNQPCSPKPIRLVQDLPEELVHAGWEKCWSRRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNATPLPQDSSLVETPPAENKPRKRQLSEEQPSGNGVKKPKIEIPVTPTGPSVPSSPSIPGTPTLKIWGTSSEDKQQAALLRPTELYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGSDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKDHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAILKENNIPEEVEAPEVEPRLVYCYPVRLAVSAPPMPSVEMHMENSVVCIRYKGEMVKVSRNYFSKLWLLYRYSCIDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFSPLSGSFEANPPFCEELMDAMVSHFERLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLVLPAFEHEYRSGSQHVCKKEEMHYKAVHNTAVLFLQNDPGFAKWGPTPERLQELSAAYRQSGRSHGSGSSSSSSEAKDRDSGREQGPSREPHPT", "length": 703 }, "evidence": [ { "id": "F1MJ19", "url": "https://omabrowser.org/oma/group/F1MJ19/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P59114-1", "protein_name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase", "gene_name": "Pcif1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MANENHGSPREGASLLSHSPGTSSQSQPCSPKPVRLVQDLPEELVHAGWEKCWSRRESRPYYFNRFTNQSLWEMPVLGQHDVLSDPLGLNATPLPQDSSLVETPPVENKSRKRQLSEEQPSGNGVKKPKIEIPVTPTSQSVPSSPSIPGTPTLKIWGSSTEDKQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPDVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGCDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKEHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAVLKENNIPEEVEASELEPRLVYCYPVRLAVSAPPMPSVEMHVENSVVCIRYKGEMVKVSRSYFSKLWLLYRYSCVDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFETLHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFTPLSGSFEANPPFCEELMDAMVSHFEKLLESSAEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLVLPAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNGPGFAKWGPTPERLQELTAAYKQSGRSHGSSSSSSSSSSSSEAKDRDSGREQGPSREPHPT", "length": 706 }, "evidence": [ { "id": "F1MJ19", "url": "https://omabrowser.org/oma/group/F1MJ19/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H4Z3-1", "protein_name": "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase", "gene_name": "PCIF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MANENHGSPREEASLLSHSPGTSNQSQPCSPKPIRLVQDLPEELVHAGWEKCWSRRENRPYYFNRFTNQSLWEMPVLGQHDVISDPLGLNATPLPQDSSLVETPPAENKPRKRQLSEEQPSGNGVKKPKIEIPVTPTGQSVPSSPSIPGTPTLKMWGTSPEDKQQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGSDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKDHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAILKENNISEEVEAPEVEPRLVYCYPVRLAVSAPPMPSVEMHMENNVVCIRYKGEMVKVSRNYFSKLWLLYRYSCIDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFAPLSGSFEANPPFCEELMDAMVSHFERLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLILPAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNDPGFAKWAPTPERLQELSAAYRQSGRSHSSGSSSSSSSEAKDRDSGREQGPSREPHPT", "length": 704 }, "evidence": [ { "id": "F1MJ19", "url": "https://omabrowser.org/oma/group/F1MJ19/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VPB7-1", "protein_name": "Phosphorylated CTD-interacting factor 1", "gene_name": "Pcif1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAANNNNSIIHNLGAGTEGLLSSVIASTGTPGMGSSPVPSRASSSSASSAAQSAWDQLTASASNNMSPSPTAGAPTVTGPILPDNLGVGAGSSPVASCSSPSTPTKTHAPSPLESMGHTPQGPPTLGPGGYGEELTAELVNQGWRKFWSKRENRPYYWNKVTGESLWEMPGTRPFDPLTDPLGICHAGGPTPIIPNMHQQQQHQHHHLKRRPSDDMHIHPNQHHMGGGPPMKKFVLAGPWDLEVCTNAVIVERPPTLLPQPHPEVEALRAAFTMKLLKTYEDLCMRRENIKAPRDSFNRWLMERKVIDTGCDPLLPSSCMPEISSSMYREIMSDIPIKIVKPKFTGDARKQLSRYAEAAKQIIESRSAPAESKKVVKWNVEDTFQWLRRTVGASYEDFQDRLAHLKRQCEPHLVETVKSSVETLCVKIYHLSADHARKIRERHSQLLKEHGIPEPTPPPPPPHLKKVWCYPIQFAVPSPRMPTIEYLQDRDHMIIKYTPATINQPDAQYINLTYLQKLEQLYRHNCFDDKKFDLFIGRVWCLLKRYQTFLGNALNSSQEAELTQAALPVPVFECLHRQFGVSFECFASPFNSYFRQYCSAFADTDAYFGSRGPFLDFKPVSGSFQVNPPHCEELIEASLLHIDKLLTDTMEPLSFIVFLPEWKSISKLDDSMYKRRSMVVLGMAHEYRHGYQHMLQKSDVLIKCMQGTQVVWLQNSAGYARWGPNEIRVEALREAFRPQRDRERERAAAAAAAAGVTSSQQSPSTPPSAASTAPTTNSCTISGVNSNSSSTATTTSTSSSPSLTTTSSSMSPLSPHTPTGNPPPQFPMTISNTSSSSNLVAASPTMSVQSDCSSPSSSTMSLSPAPASGGYPDGVTSATAAAVSITATTTTSAAGAGSAFGQANSISSSASTQAVINSAV", "length": 920 }, "evidence": [ { "id": "F1MJ19", "url": "https://omabrowser.org/oma/group/F1MJ19/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MJ19", "url": "https://www.uniprot.org/uniprotkb/F1MJ19" } ], "pmid": "" }, { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "F1MJ19", "url": "https://www.uniprot.org/uniprotkb/F1MJ19" } ], "pmid": "" }, { "name": "intercellular bridge", "id": "GO:0045171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045171", "evidence": [ { "database": "UniProtKB", "id": "F1MJ19", "url": "https://www.uniprot.org/uniprotkb/F1MJ19" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "F1MJ19", "url": "https://www.uniprot.org/uniprotkb/F1MJ19" } ], "pmid": "" }, { "name": "negative regulation of translation", "id": "GO:0017148", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148", "evidence": [ { "database": "UniProtKB", "id": "F1MJ19", "url": "https://www.uniprot.org/uniprotkb/F1MJ19" } ], "pmid": "" }, { "name": "positive regulation of translation", "id": "GO:0045727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045727", "evidence": [ { "database": "UniProtKB", "id": "F1MJ19", "url": "https://www.uniprot.org/uniprotkb/F1MJ19" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "F1MJ19", "url": "https://www.uniprot.org/uniprotkb/F1MJ19" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity", "id": "GO:0016422", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016422", "evidence": [ { "database": "UniProtKB", "id": "F1MJ19", "url": "https://www.uniprot.org/uniprotkb/F1MJ19" } ], "pmid": "" }, { "name": "S-adenosyl-L-methionine binding", "id": "GO:1904047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904047", "evidence": [ { "database": "UniProtKB", "id": "F1MJ19", "url": "https://www.uniprot.org/uniprotkb/F1MJ19" } ], "pmid": "" }, { "name": "RNA polymerase II C-terminal domain phosphoserine binding", "id": "GO:1990269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990269", "evidence": [ { "database": "UniProtKB", "id": "F1MJ19", "url": "https://www.uniprot.org/uniprotkb/F1MJ19" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJ19-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 702, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJ19-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJ19" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ19" }, { "id": "PS50020", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50020" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WW", "eco_id": "ECO_0000259", "start_pos": 43, "end_pos": 77, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.62", "ec_name": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + S-adenosyl-L-homocysteine + H(+).", "evidence": [ { "id": "2.1.1.62", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.62" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 593, 656 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 68, "end_pos": 70 }, { "start_pos": 90, "end_pos": 92 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJ29-1", "uniprot_ac": "F1MJ29", "uniprot_id": "F1MJ29_BOVIN", "mass": { "chemical_mass": 61937.0, "monoisotopic_mass": 61937.0 }, "refseq": { "ac": "XP_005212515", "name": "interleukin-18 receptor 1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212515" }, "gene_names": [ { "name": "IL18R1", "type": "recommended", "evidence": [ { "id": "F1MJ29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ29" } ] }, { "name": "IL18R1", "type": "synonym", "evidence": [ { "id": "XP_005212515", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212515" } ] } ], "protein_names": [ { "name": "Interleukin-18 receptor 1", "type": "recommended", "evidence": [ { "id": "F1MJ29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ29/entry#names_and_taxonomy" } ] }, { "name": "CD218 antigen-like family member A", "type": "synonym", "evidence": [ { "id": "F1MJ29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ29/entry#names_and_taxonomy" } ] }, { "name": "IL1 receptor-related protein", "type": "synonym", "evidence": [ { "id": "F1MJ29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ29/entry#names_and_taxonomy" } ] }, { "name": "Interleukin-18 receptor alpha", "type": "synonym", "evidence": [ { "id": "F1MJ29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ29/entry#names_and_taxonomy" } ] }, { "name": "interleukin-18 receptor 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005212515", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212515" } ] } ], "function": [ { "annotation": "Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3.", "evidence": [ { "database": "UniProtKB", "id": "F1MJ29", "url": "https://www.uniprot.org/uniprotkb/F1MJ29#function" }, { "database": "UniProtKB", "id": "ARBA00058411", "url": "https://www.uniprot.org/uniprotkb/ARBA00058411#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJ29", "url": "https://www.uniprot.org/uniprotkb/F1MJ29" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL18R1", "url": "https://www.uniprot.org/uniprotkb/F1MJ29", "locus": { "chromosome": "11", "start_pos": 7192645, "end_pos": 7165306, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001034", "url": "https://www.ensembl.org/id/ENSBTAG00000001034" } ] } } ], "crossref": [ { "id": "F1MJ29", "url": "https://alphafold.ebi.ac.uk/entry/F1MJ29", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001034", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001034", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "407221", "url": "https://www.ncbi.nlm.nih.gov/gene/407221", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000157", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000157", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004074", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004074", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015621", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015621", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:407221", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407221", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MJ29", "url": "https://www.orthodb.org/?gene=F1MJ29", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11890", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11890", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11890:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11890:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01582", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01582", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13895", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13895", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9008059", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9008059", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9012546", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9012546", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005212515", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212515", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MJ29", "url": "https://www.uniprot.org/uniprotkb/F1MJ29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ29-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ29-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHCREIPLTVWVLMFISTSEETCTSRLHITAVEGEPFYLKYCSSSPEHGKKTTTIKWYKNESHGPVDLSLRSSPRILLRDYVLEFWPVELSDSGSYSFQMGNDTHDWKLNVIPRSPHSCFTEKLVMSKAVEVKKSLQIPCEHNYYQQLANRTVLYKNCEKMENNQNPFLKNAEFKDQGYYTCVFFLHHNGKLFNVTKTFNITIVGDHSNIIPALLGPKIEEVKVELGKDIQLNCSALLNEKDIIYWNTWRKNGKDPNVHEGEVTRIRTSEGKWLASTILRIENVNTRNLNFSYNCTAVNEGGIDTKSFLLLLKEDMVDIPGHVFTRGMIVAVVISVVVVCLVTMGVIYRVDLVLFYRHFMGRDETLTDGKTYDAFVSYLKECQPEHGEEHAFAVETLPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSSEVRYELESGLHEALVERKIKIILIEFTPVGDFRFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKAVKPCRDESEASPVLLKS", "length": 538, "header": "tr|F1MJ29-1|F1MJ29_BOVIN Isoform 1 of 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"evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001371.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001371.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001371.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001371.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:407221", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407221", "resource": "KEGG Pathway" }, { "id": "R-BTA-9008059", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9008059", "resource": "Reactome", "description": "Interleukin-37 signaling" }, { "id": "R-BTA-9012546", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9012546", "resource": "Reactome", "description": "Interleukin-18 signaling" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "interleukin-18 receptor 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"tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTGIAAASFFSNTCRFGGCGLHFPTLADLIEHIEDNHIDTDPRVLEKQELQQPTYVALSYINRFMTDAARREQESLKKKIQPKLSLTLSSSVSRGNVSTPPRHSSGSLTPPVTPPITPSSSFRSSTPTGSEYDEEEVDYEESDSDESWTTESAISSEAILSSMCMNGGEEKPFACPVPGCKKRYKNVNGIKYHAKNGHRTQIRVRKPFKCRCGKSYKTAQGLRHHTINFHPPVSAEMIRKMQQ", "length": 243 }, "evidence": [ { "id": "F1MJ32", "url": "https://omabrowser.org/oma/group/F1MJ32/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80ZQ5-1", "protein_name": "Juxtaposed with another zinc finger protein 1", "gene_name": "Jazf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTGIAAASFFSNTCRFGGCGLHFPTLADLIEHIEDNHIDTDPRVLEKQELQQPTYVALSYINRFMTDAARREQESLKKKIQPKLSLTLSSSVSRGNVSTPPRHSSGSLTPPVTPPITPSSSFRSSTPTGSEYDEEEVDYEESDSDESWTTESAISSEAILSSMCMNGGEEKPFACPVPGCKKRYKNVNGIKYHAKNGHRTQIRVRKPFKCRCGKSYKTAQGLRHHTINFHPPVSAEMIRKMQQ", "length": 243 }, "evidence": [ { "id": "F1MJ32", "url": "https://omabrowser.org/oma/group/F1MJ32/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86VZ6-1", "protein_name": "Juxtaposed with another zinc finger protein 1", "gene_name": "JAZF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTGIAAASFFSNTCRFGGCGLHFPTLADLIEHIEDNHIDTDPRVLEKQELQQPTYVALSYINRFMTDAARREQESLKKKIQPKLSLTLSSSVSRGNVSTPPRHSSGSLTPPVTPPITPSSSFRSSTPTGSEYDEEEVDYEESDSDESWTTESAISSEAILSSMCMNGGEEKPFACPVPGCKKRYKNVNGIKYHAKNGHRTQIRVRKPFKCRCGKSYKTAQGLRHHTINFHPPVSAEIIRKMQQ", "length": 243 }, "evidence": [ { "id": "F1MJ32", "url": "https://omabrowser.org/oma/group/F1MJ32/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MJ32", "url": "https://www.uniprot.org/uniprotkb/F1MJ32" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MJ32", "url": "https://www.uniprot.org/uniprotkb/F1MJ32" } ], "pmid": "" }, { "name": "transcription repressor complex", "id": "GO:0017053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017053", "evidence": [ { "database": "UniProtKB", "id": "F1MJ32", "url": "https://www.uniprot.org/uniprotkb/F1MJ32" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MJ32", "url": "https://www.uniprot.org/uniprotkb/F1MJ32" } ], "pmid": "" }, { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "F1MJ32", "url": "https://www.uniprot.org/uniprotkb/F1MJ32" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MJ32", "url": "https://www.uniprot.org/uniprotkb/F1MJ32" } ], "pmid": "" }, { "name": "transcription corepressor activity", "id": "GO:0003714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "evidence": [ { "database": "UniProtKB", "id": "F1MJ32", "url": "https://www.uniprot.org/uniprotkb/F1MJ32" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJ32-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 243, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJ32-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJ32" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJ32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ32" }, { "id": "PS00028", "database": "PROSITE", "url": "https://prosite.expasy.org/PS00028" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 14, "end_pos": 37, "start_aa": "Cys", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 113 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 96, "end_pos": 98 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJ36-1", "uniprot_ac": "F1MJ36", "uniprot_id": "F1MJ36_BOVIN", "mass": { "chemical_mass": 68674.0, "monoisotopic_mass": 68674.0 }, "refseq": {}, "gene_names": [ { "name": "LOC539818", "type": "recommended", "evidence": [ { "id": "F1MJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ36" } ] } ], "protein_names": [ { "name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "type": "recommended", "evidence": [ { "id": "F1MJ36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ36/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.", "evidence": [ { "database": "UniProtKB", "id": "F1MJ36", "url": "https://www.uniprot.org/uniprotkb/F1MJ36#function" }, { "database": "UniProtKB", "id": "RU361143", "url": "https://www.uniprot.org/uniprotkb/RU361143#function" }, { "database": "UniProtKB", "id": "ARBA00002791", "url": "https://www.uniprot.org/uniprotkb/ARBA00002791#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJ36", "url": "https://www.uniprot.org/uniprotkb/F1MJ36" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC539818", "url": "https://www.uniprot.org/uniprotkb/F1MJ36", "locus": {} } ], "crossref": [ { "id": "F1MJ36", "url": "https://alphafold.ebi.ac.uk/entry/F1MJ36", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019143", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019143", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR007676", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007676", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "THYTLGY", "url": "https://omabrowser.org/oma/group/THYTLGY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR21049", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21049", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21049:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21049:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04597", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04597", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MJ36", "url": "https://www.uniprot.org/uniprotkb/F1MJ36", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ36-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ36-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEAPAVHLLPLLLLFAAWAPEPGSTSAEALPLVNEEVRRTVDLSSHLAKVTAEVVLAHTGSDSSPRAASFLVALEPEFEAQLAHLGVQVTGVDEEANSLEVQETKINGKSGRFFTVQLPVALDPGAEVSVVVEAVYTHAIQPYPIQITQSQKQFVVFEGNHYFYSPYPTKTQTMHVKLASPNVESYTKLGNPMRHENLLDYGPFHDIPAYSQDSFKVHSENNSPFLTVTSMTRVIEVSHWGNIAVEENVNLKHTGAVLKGSFSRYDYDKWIDSGISSIRSFKTILPASAQDVYYRDEIGSIYTRHLLILDDSVEMEMKPRFPLFGGWKTHYIIGYNLPSYEYLYNLGDQYVLKMRLVDHVFDKQVIDSLTVKIILPEGARNIQVDSPYEISRAPDKLYYTYLDTFGRPVIVAHKKNLVEQHIQDIMVHYTFSKVLMLQEPLLLVATFSILFFTVVIYVRLDLSITKDPAAEARMKVACIIEQVLTLVSKRLGLYHHFNKTVNRYKQSRDVSVLNSGKKSLEMEHKALTSEVALLQARLKTEGSNLCDKVSEMQKLDTQVKQLVLKSAVEAEWLVAGKLKKDMYIQNKKLISGKRQELVSKIEHILDTL", "length": 608, "header": "tr|F1MJ36-1|F1MJ36_BOVIN Isoform 1 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Bos taurus OX=9913 GN=LOC539818 PE=3 SV=1 CANONICAL=F1MJ36-1" }, "isoforms": [ { "isoform_ac": "F1MJ36-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ36/entry", "sequence": { "sequence": "MEAPAVHLLPLLLLFAAWAPEPGSTSAEALPLVNEEVRRTVDLSSHLAKVTAEVVLAHTGSDSSPRAASFLVALEPEFEAQLAHLGVQVTGVDEEANSLEVQETKINGKSGRFFTVQLPVALDPGAEVSVVVEAVYTHAIQPYPIQITQSQKQFVVFEGNHYFYSPYPTKTQTMHVKLASPNVESYTKLGNPMRHENLLDYGPFHDIPAYSQDSFKVHSENNSPFLTVTSMTRVIEVSHWGNIAVEENVNLKHTGAVLKGSFSRYDYDKWIDSGISSIRSFKTILPASAQDVYYRDEIGSIYTRHLLILDDSVEMEMKPRFPLFGGWKTHYIIGYNLPSYEYLYNLGDQYVLKMRLVDHVFDKQVIDSLTVKIILPEGARNIQVDSPYEISRAPDKLYYTYLDTFGRPVIVAHKKNLVEQHIQDIMVHYTFSKVLMLQEPLLLVATFSILFFTVVIYVRLDLSITKDPAAEARMKVACIIEQVLTLVSKRLGLYHHFNKTVNRYKQSRDVSVLNSGKKSLEMEHKALTSEVALLQARLKTEGSNLCDKVSEMQKLDTQVKQLVLKSAVEAEWLVAGKLKKDMYIQNKKLISGKRQELVSKIEHILDTL", "length": 608, "header": "tr|F1MJ36-1|F1MJ36_BOVIN Isoform 1 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Bos taurus OX=9913 GN=LOC539818 PE=3 SV=1 CANONICAL=F1MJ36-1" }, "locus": { "chromosome": "8", "start_pos": 64537696, "end_pos": 64535873, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025481.3", "url": "https://www.ensembl.org/id/ENSBTAT00000025481.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049552.1", "url": "https://www.ensembl.org/id/ENSBTAP00000049552.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "P41543-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "gene_name": "OST1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MRQVWFSWIVGLFLCFFNVSSAAQYEPPATWENVDYKRTIDVSNAYISETIEITIKNIASEPATEYFTAFESGIFSKVSFFSAYFTNEATFLNSQLLANSTTAPGDDGESEIRYGIIQFPNAISPQEEVSLVIKSFYNTVGIPYPEHVGMSEEQHLLWETNRLPLSAYDTKKASFTLIGSSSFEEYHPPNDESLLGKANGNSFEFGPWEDIPRFSSNETLAIVYSHNAPLNQVVNLRRDIWLSHWASTIQFEEYYELTNKAAKLSKGFSRLELMKQIQTQNMRQTHFVTVLDMLLPEGATDHYFTDLVGLVSTSHAERDHFFIRPRFPIFGGWNYNFTVGWTNKLSDFLHVSSGSDEKFVASIPILNGPPDTVYDNVELSVFLPEGAEIFDIDSPVPFTNVSIETQKSYFDLNKGHVKLTFSYRNLISQVANGQVLIKYDYPKSSFFKKPLSIACYIFTALMGVFVLKTLNMNVTN", "length": 476 }, "evidence": [ { "id": "F1MJ36", "url": "https://omabrowser.org/oma/group/F1MJ36/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q76NQ0-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1", "gene_name": "Ost1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MYVSKFEASMATNFVIYLALGALLCLATANGEIVNTNVERTLDLTSQLVKTTTKISAEDSAGKPIVEYVFFTSEPSLAYIDVKDASDKSVPFKRNEPVKGEQSFTFTFPRAAAKQTFIVETVASKGIRPHPEEIRQNDKQFVKYTGNLHLYSKYRTNSQKTNVKLSSSNILSHTQVKPFSVSSNKITLGPYENVEAFSQEPLVIHYENSAPFVTVNTLERTLEISHWGNIAVQESIQMTHTGAKLKGSFSRYDFQKEGRSGLAALKSYKTYLPASASGVYYRDTNGNISTSNMNAVRDFIELELRPRFPLFGGWKTQYTLGYNVPSYEYMFNDGNKYQLKMHLIDHIYDNMAIDEATIKIILPEGSSDIRLSTPYSISRLPNELVHTYLDTIGRPVVSFSKSNLVESHISDFTLHYSFSKTSMLQEPLLVSGFIYIIFLFTIVFLRLDFSITSHAHKE", "length": 458 }, "evidence": [ { "id": "F1MJ36", "url": "https://omabrowser.org/oma/group/F1MJ36/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9ZUA0-1", "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B", "gene_name": "OST1B", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAARIGIFSVFVAVLLSISAFSSAQDLQIVNAERRIDLSSHIVKAFLTLKVENIGKDPAAEMLLAFPPTQIKNLAMVQALATTGKKKKKTYLPLDVKPTEQPDAPNDTGYYRVTFISPLGPGETVSLEVLYILTHSLEPFPVEITQSESQLVYYHDSAVILSPYHVKQQTTFIKTPSTRVESFTSIEPANRAGKEIKYGPYENRASYSYTPVIIHFENNSPFAVVEELVREIEISHWGSLQITENYRLTHGGARHKGVFSRVDYQSKRSVSGASSFNALLAVLPPRVNSVYYRDEIGNISTSHLRTGFRKSELEFEPRYPLFGGWSATFIIGYRVPLEDYLFEASDGRRYLNFTFGCPLVETIVNKLTIKVVLPEGSKDPSAVLPFTVNQELQVKYSYLDIVGRTVVVLQKDNVVPTHNVPFQVYYTFKPIYMLAEPFMLVSAFFLVFVASLAYVHIDLNIVRK", "length": 464 }, "evidence": [ { "id": "F1MJ36", "url": "https://omabrowser.org/oma/group/F1MJ36/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "glycoprotein biosynthetic process", "id": "GO:0009101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009101", "evidence": [ { "database": "UniProtKB", "id": "F1MJ36", "url": "https://www.uniprot.org/uniprotkb/F1MJ36" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "oligosaccharyltransferase complex", "id": "GO:0008250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008250", "evidence": [ { "database": "UniProtKB", "id": "F1MJ36", "url": "https://www.uniprot.org/uniprotkb/F1MJ36" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" }, { "start_pos": 498, "end_pos": 500, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJ36-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 608, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJ36-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJ36" } ], "lectin_list": [], 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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{ "database": "Ensembl Gene", "id": "ENSBTAG00000031412", "url": "https://www.ensembl.org/id/ENSBTAG00000031412" } ] } } ], "crossref": [ { "id": "F1MJ48", "url": "https://alphafold.ebi.ac.uk/entry/F1MJ48", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000031412", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000031412", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13954", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13954", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "518429", "url": "https://www.ncbi.nlm.nih.gov/gene/518429", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { 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"PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00026", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00026", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07966", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07966", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MJ49", "url": "https://www.uniprot.org/uniprotkb/F1MJ49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJ49-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ49-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKWLVLLGLVALSECIVKIPLTKMKTMQEAIREKQLLEDFLDEQPHSLSQHSDPDKKFSSHQLKNFQNAVYFGTITIGTPPQEFQVNFDTGSSDLWVPSVDCQSPSCSKHKRFDPQKSTTFQPLNQKIELVYGSGSMKGVLGSDTIQIGNLVIVNQIFGLSQNQSSGVLEQVPYDGILGLAYPSLAIQGTTPVFDNLKNREVISEPVFAFYLSSRPENISMVMFGGVDHTYHKGKLQWIPVTQARFWQVAMSSMTMNGNVVGCSQGCQAVVDTGTSLLVGPTHLVTDILKLINPNPILNDEQMLSCDAINSLPTLLLTINGIVYPVPPDYYIQRFSERICFISFQGGTEILKNLGTSETWILGDVFLRLYFSVYDRGNNRIGLAPAA", "length": 387, "header": "tr|F1MJ49-1|F1MJ49_BOVIN Isoform 1 of Pregnancy-associated glycoprotein 8 OS=Bos taurus OX=9913 GN=PAG8 PE=3 SV=2 CANONICAL=F1MJ49-1" }, "isoforms": [ { "isoform_ac": "F1MJ49-1", "url": "https://www.uniprot.org/uniprotkb/F1MJ49/entry", "sequence": { "sequence": "MKWLVLLGLVALSECIVKIPLTKMKTMQEAIREKQLLEDFLDEQPHSLSQHSDPDKKFSSHQLKNFQNAVYFGTITIGTPPQEFQVNFDTGSSDLWVPSVDCQSPSCSKHKRFDPQKSTTFQPLNQKIELVYGSGSMKGVLGSDTIQIGNLVIVNQIFGLSQNQSSGVLEQVPYDGILGLAYPSLAIQGTTPVFDNLKNREVISEPVFAFYLSSRPENISMVMFGGVDHTYHKGKLQWIPVTQARFWQVAMSSMTMNGNVVGCSQGCQAVVDTGTSLLVGPTHLVTDILKLINPNPILNDEQMLSCDAINSLPTLLLTINGIVYPVPPDYYIQRFSERICFISFQGGTEILKNLGTSETWILGDVFLRLYFSVYDRGNNRIGLAPAA", "length": 387, "header": "tr|F1MJ49-1|F1MJ49_BOVIN Isoform 1 of Pregnancy-associated glycoprotein 8 OS=Bos taurus OX=9913 GN=PAG8 PE=3 SV=2 CANONICAL=F1MJ49-1" }, "locus": { "chromosome": "29", "start_pos": 39736389, "end_pos": 39726336, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025597.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025597.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025597.4", "url": "https://www.ensembl.org/id/ENSBTAP00000025597.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MJ49", "url": "https://www.uniprot.org/uniprotkb/F1MJ49" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1MJ49", "url": "https://www.uniprot.org/uniprotkb/F1MJ49" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "aspartic-type endopeptidase activity", "id": "GO:0004190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004190", "evidence": [ { "database": "UniProtKB", "id": "F1MJ49", "url": "https://www.uniprot.org/uniprotkb/F1MJ49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 218, "end_pos": 220, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJ49-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 387, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJ49-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJ49" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJ49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ49" }, { "id": "PS51767", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51767" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase A1", "eco_id": "ECO_0000259", "start_pos": 71, "end_pos": 384, "start_aa": "Tyr", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 163, "end_pos": 165 }, { "start_pos": 218, "end_pos": 220 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJA5-1", "uniprot_ac": "F1MJA5", "uniprot_id": "F1MJA5_BOVIN", "mass": { "chemical_mass": 98662.0, "monoisotopic_mass": 98662.0 }, "refseq": { "ac": "XP_024856486", "name": "protein FAM171A1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856486" }, "gene_names": [ { "name": "FAM171A1", "type": "recommended", "evidence": [ { "id": "F1MJA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJA5" } ] }, { "name": "C13H10ORF38", "type": "synonym", "evidence": [ { "id": "XP_024856486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856486" } ] }, { "name": "FAM171A1", "type": "synonym", "evidence": [ { "id": "XP_024856486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856486" } ] } ], "protein_names": [ { "name": "Family with sequence similarity 171 member A1", "type": "synonym", "evidence": [ { "id": "F1MJA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJA5/entry#names_and_taxonomy" } ] }, { "name": "protein FAM171A1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024856486", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856486" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJA5", "url": "https://www.uniprot.org/uniprotkb/F1MJA5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FAM171A1", "url": "https://www.uniprot.org/uniprotkb/F1MJA5", "locus": { "chromosome": "13", "start_pos": 29781616, "end_pos": 29913709, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000008787", "url": "https://www.ensembl.org/id/ENSBTAG00000008787" } ] } } ], "crossref": [ { "id": "F1MJA5", "url": "https://alphafold.ebi.ac.uk/entry/F1MJA5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000008787", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000008787", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "534850", "url": "https://www.ncbi.nlm.nih.gov/gene/534850", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR018890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048530", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048530", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049175", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049175", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PAECMMS", "url": "https://omabrowser.org/oma/group/PAECMMS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MJA5", "url": "https://www.orthodb.org/?gene=F1MJA5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31626", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31626", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31626:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31626:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10577", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10577", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20771", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20771", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024856486", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856486", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MJA5", "url": "https://www.uniprot.org/uniprotkb/F1MJA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJA5-1", "url": "https://www.uniprot.org/uniprotkb/F1MJA5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRSAALLLCLLGCHVWKAVTKTLREPGAGAQEVTLKVHISDASTHQPVPDALIEIFTNQVSIASGTSGTDGVAFIKFQYKLGSQLIVTATKHAYVPNSAPWKPIRLPVFSSLSLGLLPERSATLMVYEDVVQIVSGFQGARPQPRVHFQRRALRLPENTSYSDLTAFLTAASSPSEVDGFPYLRGLDGNGTGNSTRYDLTPVTAVSVHLLSSDGTRVLVDGPIYVTVPLATQSSLRHNAYVTAWRFDQKLGTWLKSGLGLVHQEGSQLTWTYIAPQLGYWVAAMSPPNPGPVVTQDITTYHTVFLLAILGGMAFILLVLLCLLLYYCRRKCLKPRQHHRKLQLPATLESSKRDQSTSMSHINLLFSRRESEFPGPLSVTSQGRPPDAPGSKELMSGVHLEMMSSNGEVDMHTPMLKLSYSTSQEFSSREELLSHKEEDKSQISFDNLTPSGTLGKDYHKSVEIFPLKARKPMEREGYESSGNSDYRRSYNAMLSQPLFEKQDRESQASVTHISTGSKLTIQEHMYPAPSSPEKDQLLERRPTECMMSRSVDHLERPTSFPRPGQLICCSSVDQVNDSVYRKVLPALVIPAHYMKLPGDHSYVGQPLVVPADPQLEIERLQAELSSPHAGIFPHPSAQIQAQPLSCQAISQQHLQDTGAREWTPQSASMSESLSIPASLNDAALAQMNSEVQLLTEKALLELGGGKPLPHPRAWFVSLDGRSNAHVRHSYIDLQRAGRNGSNDASLDSGVDMNEPKSARKGRGDPSTLPQSHPPVQEHPQKESRAADSSAYTQLVYLEDMDQSGSEGGTTAGTPEDSALRCLLDGSSRRSGGQLPSLQEETTKRISDVAPEPAASPDQRRSAPQDEEDDEDDDDQGEDKKSPWQKREERPLMAFNIK", "length": 897, "header": "tr|F1MJA5-1|F1MJA5_BOVIN Isoform 1 of Family with sequence similarity 171 member A1 OS=Bos taurus OX=9913 GN=FAM171A1 PE=3 SV=3 CANONICAL=F1MJA5-1" }, "isoforms": [ { "isoform_ac": "F1MJA5-1", "url": "https://www.uniprot.org/uniprotkb/F1MJA5/entry", "sequence": { "sequence": "MSRSAALLLCLLGCHVWKAVTKTLREPGAGAQEVTLKVHISDASTHQPVPDALIEIFTNQVSIASGTSGTDGVAFIKFQYKLGSQLIVTATKHAYVPNSAPWKPIRLPVFSSLSLGLLPERSATLMVYEDVVQIVSGFQGARPQPRVHFQRRALRLPENTSYSDLTAFLTAASSPSEVDGFPYLRGLDGNGTGNSTRYDLTPVTAVSVHLLSSDGTRVLVDGPIYVTVPLATQSSLRHNAYVTAWRFDQKLGTWLKSGLGLVHQEGSQLTWTYIAPQLGYWVAAMSPPNPGPVVTQDITTYHTVFLLAILGGMAFILLVLLCLLLYYCRRKCLKPRQHHRKLQLPATLESSKRDQSTSMSHINLLFSRRESEFPGPLSVTSQGRPPDAPGSKELMSGVHLEMMSSNGEVDMHTPMLKLSYSTSQEFSSREELLSHKEEDKSQISFDNLTPSGTLGKDYHKSVEIFPLKARKPMEREGYESSGNSDYRRSYNAMLSQPLFEKQDRESQASVTHISTGSKLTIQEHMYPAPSSPEKDQLLERRPTECMMSRSVDHLERPTSFPRPGQLICCSSVDQVNDSVYRKVLPALVIPAHYMKLPGDHSYVGQPLVVPADPQLEIERLQAELSSPHAGIFPHPSAQIQAQPLSCQAISQQHLQDTGAREWTPQSASMSESLSIPASLNDAALAQMNSEVQLLTEKALLELGGGKPLPHPRAWFVSLDGRSNAHVRHSYIDLQRAGRNGSNDASLDSGVDMNEPKSARKGRGDPSTLPQSHPPVQEHPQKESRAADSSAYTQLVYLEDMDQSGSEGGTTAGTPEDSALRCLLDGSSRRSGGQLPSLQEETTKRISDVAPEPAASPDQRRSAPQDEEDDEDDDDQGEDKKSPWQKREERPLMAFNIK", "length": 897, "header": "tr|F1MJA5-1|F1MJA5_BOVIN Isoform 1 of Family with sequence similarity 171 member A1 OS=Bos taurus OX=9913 GN=FAM171A1 PE=3 SV=3 CANONICAL=F1MJA5-1" }, "locus": { "chromosome": "13", "start_pos": 29913586, "end_pos": 29782907, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032523.6", "url": "https://www.ensembl.org/id/ENSBTAT00000032523.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032454.5", "url": "https://www.ensembl.org/id/ENSBTAP00000032454.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A480QHM0-1", "protein_name": "Family with sequence similarity 171 member A1", "gene_name": "FAM171A1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSRSTALLLCLLGCNVWKAVTKTLREPGAGAQEVTLKVHISDASTHQPIPEALIEIFTNQVSIATGTSGTDGVAFIKFQYKLGSQLMVTATKHAYVPNSAPWKPIRLPVFSSLSLGLLPERSATLMVYEDVVQIVSGFQGARPQPRVHFQRRALRLPENTSYSDLTAFLTAASSPSEVDGFPYLRGLDGNGTGNGTRYDLTPVTAVSVHLLSSDGTPVLVDGPIYVTVPLATQSSLRHNAYVTAWRFDQKLGTWLKSGLGLVHQEGSQLTWTYIAPQLGYWVAAMSPPNPGPVVTQDITTYHTVFLLAILGGMAFILLVLLCLLLYYCRRKCLKPRQHHRKLQLPATLESSKKDQSTSMSHINLLFSRRESEFPGPLSVTSQGRPPDAPGSKELMSGVHLEMVSSNGEADLHTPMLKLSYSTSQEFSSREELLSHKEEDKSQISFDNLTPSGTLGKDYHKSVEIFPLKSRKSLEREGCESPGSTDYRRSYNAMLSQPLFEKQDRDGQAPINHISAGSKLAIQEHMYPTPSSPEKEQLLERRPTECMMSRSVDHLERPTSFPRPGQLICCSSVDQVNDSVYRKVLPALVIPAHYMKLPGDHSYVGQPLVVPADQQLEIERLQAELSSPHAGIFPHPSSQIQAQPLSCQAISQQHLQDAGTREWTPQSAAMSESLSIPASLNDAALAQMNSEVQLLTEKALLELGGGKPLPHPRAWFVSLDGRSNAHVRHSYIDLQRAGRNGSNDASLDSGVDMNEPKSARKARGDPLSLPQNHPPVQEHPQKEPRAADGGAAYTQLVYLEDLDQSSGGEGGPAVGTPEDSALRCLLDGSSRRSGGQLPSLQEETTKRTSGVPPEPPASPDPKRSAQEDEEDEDDDDDQGEDKKSPWQKREERPLMAFNIK", "length": 899 }, "evidence": [ { "id": "F1MJA5", "url": "https://omabrowser.org/oma/group/F1MJA5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XI74-1", "protein_name": "Family with sequence similarity 171 member A1", "gene_name": "FAM171A1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MVSFMTEPAVSLKSSCLNWRAAGQEERSYCHQSFREVTLKVHVSDASTHQPVTEAFIEIFTNQISIASGTSGADGTAFLKFQYKLGNQLIVTASKHAYVPNSAPWKPVRLPVFSSLSLGLLPERSATLMVYDDVVQIVSGFQGARTQPQVHFQRRSVKLPENTSYSDLTAYLTAASSPWEVDSFPYLQGLDGNGTGNSTRYDLTPVAAVSVHLLNSDGTPVPVNGPIYVTVPLPTNSNLKHNAHIPAWRFDQKFGTWLKSSLGLVQQEGNQLTWTYIAPQLGYWVAAMSPTIPGPVVTHDITSYHTMFLLAILGGMALILLVLLCLLLYYCRRKCLRPRQHHKKLQLPTALDTSKKDQATSMSHINLIFSRRESEFPGGLSVASNGHTENSGAKELISAVHMEMVSPSGEADMHTPMLKHSFSTSQEFSSREELLSDKEKDKSRISLDDLTPSGSLRKDYHKSADSFPLKTRKSTETAEGYESPVKDEYRRSYNAMLSQPLFEKQEREIQVSMNHIATGSKYNIQEQIYPTPSAPEKELLDCRPTECMMSRSVDHLERPTSFPRPGQLICCNSVDQVNDSVYRKVLPALVIPGHYMKLPEHSFVSQPLVVPADQPIDLERLQAELPNPHARLFPHPPQQLQPQQLTSQAISQQHLQDAGAAEWSQQNASMSESISIPASLNDASLAQMNSEVQLLTEKALMELGGGKPLPHPRAWFVSLDGRSNAHVRHSYIDLQRAGRNGSNDASLDSGVDMNEPKSARKGRGDHLSTPQSHPPVQEHQQRERKVSDSTAYTQLVYLDDMDQSGSECGTAVCSPEDNALRCLLEGTSKRSGVQLPSLQEETRTVDTKPEPLTSPEHGTSGQDEEEDEEDEEDDQGEDKKSPWQKREERPLMTFNLK", "length": 897 }, "evidence": [ { "id": "F1MJA5", "url": "https://omabrowser.org/oma/group/F1MJA5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0ABK0M7I5-1", "protein_name": "Family with sequence similarity 171, member A1", "gene_name": "Fam171a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYGACVLSVVTQRDFEGLESGGTAAGNSSHGAPEARGSGTPGTPAVRRPPEVTLKVHVSDASTHQPIADALIEVFASQVSVASGTSGTDGVAFIKFPYKLGNQLIVTATKHAYVPNSSPWKPIRLPVFSSLSLGLLPERSATLMVYEDVVQIVSGFQGARPQPRVHFQRRALRLPENTSYSALTAFLTAASSPSEVDSFPYLRGLDGNGTGNSTRYDLTPVTAVSVHLLSGNGTPVLVDGPIYVTVPLATQSSLRHNAYVAAWRFDQKLGTWLKSGLGLVHQEGSQLTWTYIAPQLGYWVAAMSPPIPGPVVTPDITTYHTVFLLAILGGMAFILLVLLCLLLYYCRRKCLKPRQHHRKLHLPPVLESSKRDQSTSMSHINLLFSRRASDYPGPLSVSSHSRPEAPGTKELMGGVHLEMMSPNGEGDLHTPMLKLSYSTSQEFSSREELLSHKEEDKSQTSFDNLTPSGTLGKEYHKSVEIFPLKARKSMEKEGYQAPSNDDYRGSYNTVLSQPSFEKQDQEGLTSAGSKLTIQEHMYHVPLSPGKEQLLDRRPTECMMSRSVDHLERPTSFPRPGQLICCSSVDQVNDSVYRKVLPALVIPAHYMKLPGDHSYVSQPLVVPADQQLEIGRLQAELSNPHAGIFPHPSSQIQGQPLSSQAISQQHLQDAGAREWSSQNAPMSESLSIPASLNDAALAQMNSEVQLLTEKALMELGGGKPLPHPRAWFVSLDGRSNAHVRHSYIDLQRAGRNGSNDASLDSGVDMNEPKSARKGRGDPLSLQQSHPPLQEHQQKDPRAPDSAPYTQLVYLEDVDQSRGECAATVCAPEDSALRCLLEGSGRRSGGQLPSLQEETTKRTSDVPLEPLASPNQRRSANDEEEDDDDDDDDDQGEDKKSPWQKREERPLMAFNIK", "length": 911 }, "evidence": [ { "id": "F1MJA5", "url": "https://omabrowser.org/oma/group/F1MJA5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A2ATK9-1", "protein_name": "Family with sequence similarity 171, member A1", "gene_name": "Fam171a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSKSAALLLCLLGCHVWKAVTKTLQEPGAGAQEVTLKVHISDASTHQPIADALIEIFASQVSVASGTSGTDGVAFIKFPYKLGNQLIVTATKQAYVPNSAPWKPIRLPVFSSLSLGLLPERSATLMVYEDVVQIVSGFQGARPQPRVHFQRRALRLPENTSYSDLTAFLTAASSPSEVDSFPYLRGLDGNGTGNSTRYDLTPVTAVSVHLLSGNGMPVLVDGPIYVTVPLATQSSLRHNAYVAAWRFDQKLGTWLKSGLGLVHQEGSQLTWTYIAPQLGYWVAAMSPPIPGPVMTQDITTYHTVFLLAILGGMAFILLVLLCLLLYYCRRKCLKPRQHHRKLQLPPALESSKRDQATSMSHINLLFSRRASDYPGPLSVSSHSRPEAPGTKELMGGVHLEMMSPKGEGDLHTPMLKLSYSTSQEFSSREELLSHKEEDKSQTSFDNLTPSGTLGKDYHKSVEIFPLKARKSMEKEDYEAPGNDDYRGSYNTVLSQSLFEKQDQEGLASAGSKLTIQEHMYHVPLSPEKEQLLDRRPTECMMSRSVDHLERPTSFPRPGQLICCSSVDQVNDSVYRKVLPALVIPAHYMKLPGDHSYVSQPLVVPADQQLEIGRLQAELSNPHAGIFPHPSSQIQGQPLSSQAISQQHLQEAGAREWSSQSASMSESLSIPASLNDAALAQMNSEVQLLTEKALMELGGGKPLPHPRAWFVSLDGRSNAHVRHSYIDLQRAGRNGSNDASLDSGVDMNEPKSARKGRGDPLSLQQSHTPLQEHQQKDPRAPDSTACTQLLYLEDMDPSGSECAATVCTPEDSALRCLLEGSGRRSGGQLPSLQEETTKRTSDVPLEPLASPNQRRSANDEDEDDDDDDDDQGEDKKSPWQKREERPLMAFNIK", "length": 892 }, "evidence": [ { "id": "F1MJA5", "url": "https://omabrowser.org/oma/group/F1MJA5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5VUB5-1", "protein_name": "Protein FAM171A1", "gene_name": "FAM171A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRSATLLLCLLGCHVWKAVTKTLREPGAGAQEVTLKVHISDASTHQPVADALIEIFTNQASIASGTSGTDGVAFIKFQYKLGSQLIVTASKHAYVPNSAPWKPIRLPVFSSLSLGLLPERSATLMVYEDVVQIVSGFQGARPQPRVHFQRRALRLPENTSYSDLTAFLTAASSPSEVDSFPYLRGLDGNGTGNSTRHDLTPVTAVSVHLLSSNGTPVLVDGPIYVTVPLATQSSLRHNAYVAAWRFDQKLGTWLKSGLGLVHQEGSQLTWTYIAPQLGYWVAAMSPPIPGPVVTQDITTYHTVFLLAILGGMAFILLVLLCLLLYYCRRKCLKPRQHHRKLQLPAGLESSKRDQSTSMSHINLLFSRRASEFPGPLSVTSHGRPEAPGTKELMSGVHLEMMSPGGEGDLHTPMLKLSYSTSQEFSSREELLSCKEEDKSQISFDNLTPSGTLGKDYHKSVEVFPLKARKSMEREGYESSGNDDYRGSYNTVLSQPLFEKQDREGPASTGSKLTIQEHLYPAPSSPEKEQLLDRRPTECMMSRSVDHLERPTSFPRPGQLICCSSVDQVNDSVYRKVLPALVIPAHYMKLPGDHSYVSQPLVVPADQQLEIERLQAELSNPHAGIFPHPSSQIQPQPLSSQAISQQHLQDAGTREWSPQNASMSESLSIPASLNDAALAQMNSEVQLLTEKALMELGGGKPLPHPRAWFVSLDGRSNAHVRHSYIDLQRAGRNGSNDASLDSGVDMNEPKSARKGRGDALSLQQNYPPVQEHQQKEPRAPDSTAYTQLVYLDDVEQSGSECGTTVCTPEDSALRCLLEGSSRRSGGQLPSLQEETTRRTADAPSEPAASPHQRRSAHEEEEDDDDDDQGEDKKSPWQKREERPLMAFNIK", "length": 890 }, "evidence": [ { "id": "F1MJA5", "url": "https://omabrowser.org/oma/group/F1MJA5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MJA5", "url": "https://www.uniprot.org/uniprotkb/F1MJA5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "F1MJA5", "url": "https://www.uniprot.org/uniprotkb/F1MJA5" } ], "pmid": "" }, { "name": "stress fiber assembly", "id": "GO:0043149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043149", "evidence": [ { "database": "UniProtKB", "id": "F1MJA5", "url": "https://www.uniprot.org/uniprotkb/F1MJA5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 194, "end_pos": 196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 447, "end_pos": 449, "annotation": "n_glycosylation_sequon" }, { "start_pos": 576, "end_pos": 578, "annotation": "n_glycosylation_sequon" }, { "start_pos": 739, "end_pos": 741, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJA5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 897, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJA5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJA5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJA5" }, { "id": "PF20771", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20771" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAM171 C-terminal", "eco_id": "ECO_0000259", "start_pos": 398, "end_pos": 895, "start_aa": "Val", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJA5" }, { "id": "PF10577", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10577" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAM171 N-terminal", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 287, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 159, "end_pos": 161 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 194, "end_pos": 196 }, { "start_pos": 447, "end_pos": 449 }, { "start_pos": 576, "end_pos": 578 }, { "start_pos": 739, "end_pos": 741 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJB1-1", "uniprot_ac": "F1MJB1", "uniprot_id": "F1MJB1_BOVIN", "mass": { "chemical_mass": 25546.0, "monoisotopic_mass": 25546.0 }, "refseq": {}, "gene_names": [ { "name": "DTYMK", "type": "recommended", "evidence": [ { "id": "F1MJB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJB1" } ] } ], "protein_names": [ { "name": "Thymidylate kinase", "type": "recommended", "evidence": [ { "id": "F1MJB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJB1/entry#names_and_taxonomy" } ] }, { "name": "2.7.4.9", "type": "synonym", "evidence": [ { "id": "F1MJB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJB1/entry#names_and_taxonomy" } ] }, { "name": "dTMP kinase", "type": "synonym", "evidence": [ { "id": "F1MJB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJB1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+).", "evidence": [ { "database": "UniProtKB", "id": "F1MJB1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1#function" }, { "database": "UniProtKB", "id": "ARBA00056272", "url": "https://www.uniprot.org/uniprotkb/ARBA00056272#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJB1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DTYMK", "url": "https://www.uniprot.org/uniprotkb/F1MJB1", "locus": { "chromosome": "3", "start_pos": 120728099, "end_pos": 120737165, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015408", "url": "https://www.ensembl.org/id/ENSBTAG00000015408" } ] } } ], "crossref": [ { "id": "F1MJB1", "url": "https://alphafold.ebi.ac.uk/entry/F1MJB1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015408", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015408", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01672", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01672", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR018094", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018094", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018095", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018095", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039430", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039430", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MJB1", "url": "https://www.orthodb.org/?gene=F1MJB1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10344", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10344", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10344:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10344:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02223", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02223", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-499943", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-499943", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "13517", "url": "https://www.rhea-db.org/rhea/13517", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MJB1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJB1-1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRSAGGPGQWWREGAAMAGRRGALIVLEGVDRAGKSTQSRKLVDALCAEGHRAELLRFPERSTEIGKLLSSYLEKKSEVEDHSVHLLFSANRWEHVPLMKEKLSQGVTLVVDRYAFSGVAFTSAKENFSLDWCKQPDVGLPKPDLVVFLQLQLAEAAARGEFGRERYESGPFQQRALQRFQQLLADPSLPWKMVNASRSIEDVHREIRALSEDAIRAAAHRPLGQLWA", "length": 228, "header": "tr|F1MJB1-1|F1MJB1_BOVIN Isoform 1 of Thymidylate kinase OS=Bos taurus OX=9913 GN=DTYMK PE=3 SV=3 CANONICAL=F1MJB1-1" }, "isoforms": [ { "isoform_ac": "F1MJB1-1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1/entry", "sequence": { "sequence": "MRSAGGPGQWWREGAAMAGRRGALIVLEGVDRAGKSTQSRKLVDALCAEGHRAELLRFPERSTEIGKLLSSYLEKKSEVEDHSVHLLFSANRWEHVPLMKEKLSQGVTLVVDRYAFSGVAFTSAKENFSLDWCKQPDVGLPKPDLVVFLQLQLAEAAARGEFGRERYESGPFQQRALQRFQQLLADPSLPWKMVNASRSIEDVHREIRALSEDAIRAAAHRPLGQLWA", "length": 228, "header": "tr|F1MJB1-1|F1MJB1_BOVIN Isoform 1 of Thymidylate kinase OS=Bos taurus OX=9913 GN=DTYMK PE=3 SV=3 CANONICAL=F1MJB1-1" }, "locus": { "chromosome": "3", "start_pos": 120736667, "end_pos": 120728249, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020478.6", "url": "https://www.ensembl.org/id/ENSBTAT00000020478.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020478.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020478.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-499943", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-499943", "resource": "Reactome", "description": "Interconversion of nucleotide di- and triphosphates" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "thymidine biosynthetic process", "id": "GO:0046105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046105", "evidence": [ { "database": "UniProtKB", "id": "F1MJB1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1" } ], "pmid": "" }, { "name": "dTDP biosynthetic process", "id": "GO:0006233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006233", "evidence": [ { "database": "UniProtKB", "id": "F1MJB1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1" } ], "pmid": "" }, { "name": "dUDP biosynthetic process", "id": "GO:0006227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006227", "evidence": [ { "database": "UniProtKB", "id": "F1MJB1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1" } ], "pmid": "" }, { "name": "dTTP biosynthetic process", "id": "GO:0006235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006235", "evidence": [ { "database": "UniProtKB", "id": "F1MJB1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MJB1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1" } ], "pmid": "" }, { "name": "dTMP kinase activity", "id": "GO:0004798", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004798", "evidence": [ { "database": "UniProtKB", "id": "F1MJB1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1" } ], "pmid": "" }, { "name": "nucleoside diphosphate kinase activity", "id": "GO:0004550", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004550", "evidence": [ { "database": "UniProtKB", "id": "F1MJB1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MJB1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MJB1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1MJB1", "url": "https://www.uniprot.org/uniprotkb/F1MJB1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 195, "end_pos": 197, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13517", "name": "", "equation": "dTMP + ATP = dTDP + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJB1-1" ], "evidence": [ { "id": "13517", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13517" } ] }, { "id": "R-BTA-73635", "name": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJB1-1" ], "evidence": [ { "id": "R-BTA-73635", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73635" } ] }, { "id": "R-BTA-75126", "name": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJB1-1" ], "evidence": [ { "id": "R-BTA-75126", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75126" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MJB1", "gene_name": "DTYMK", "activity": [ { "ec_number": "2.7.4.9", "activity": "dTMP + ATP = dTDP + ADP.", "evidence": [ { "id": "F1MJB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJB1" } ] }, { "ec_number": "2.7.4.9", "activity": "", "evidence": [ { "id": "F1MJB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJB1" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJB1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 228, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": 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"table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", 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"Protein Classification", "Other" ] }, { "id": "PF00932", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00932", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001263282", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263282", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MJI7", "url": "https://www.uniprot.org/uniprotkb/F1MJI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJI7-1", "url": "https://www.uniprot.org/uniprotkb/F1MJI7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPPSRGRRSEQRGPRTTAAAAAAMATPQPGRAGGPSTPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLQLKISEREEVTTREVSGIKTLYEAELADARRVLDETARDRACLQIEMGKLRAELEEATKSAKKREGELTVAQGRVRDLESVFHRSEAELAAALSDKRTLENDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELAFRKDVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRAQHDEQVRLYRLELEQTYQAKLDNAKLSSDQNDKAASAAREELKEARMRVESLSYQLSSLQKQASAAEDRIRELEETVAGERDKFRKMLDAKEREMMEVRDMMQQQLAEYQELLDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRITISRATTSSSGSSVSTAGRPGRSKRKRLEVQEPPGTGSSGLGSSSSTSSGGSFHLAQQASASGSVSIEEIDLEGRFVQLKNSSDKDQSLGNWRIKRQVLEGEEISYKFTPKYVLRAGQTVTVWAAGAGVAHSPPSTLVWKSQNSWGTGESFRTTLVNADGEEVAMRTVKQSSVVRETENGEEGEDEAAEFGEEDLFHQQGDPRTTSRGCRVM", "length": 628, "header": "tr|F1MJI7-1|F1MJI7_BOVIN Isoform 1 of Lamin-B2 OS=Bos taurus OX=9913 GN=LMNB2 PE=3 SV=2 CANONICAL=F1MJI7-1" }, "isoforms": [ { "isoform_ac": "F1MJI7-1", "url": "https://www.uniprot.org/uniprotkb/F1MJI7/entry", "sequence": { "sequence": "MSPPSRGRRSEQRGPRTTAAAAAAMATPQPGRAGGPSTPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLQLKISEREEVTTREVSGIKTLYEAELADARRVLDETARDRACLQIEMGKLRAELEEATKSAKKREGELTVAQGRVRDLESVFHRSEAELAAALSDKRTLENDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELAFRKDVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRAQHDEQVRLYRLELEQTYQAKLDNAKLSSDQNDKAASAAREELKEARMRVESLSYQLSSLQKQASAAEDRIRELEETVAGERDKFRKMLDAKEREMMEVRDMMQQQLAEYQELLDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRITISRATTSSSGSSVSTAGRPGRSKRKRLEVQEPPGTGSSGLGSSSSTSSGGSFHLAQQASASGSVSIEEIDLEGRFVQLKNSSDKDQSLGNWRIKRQVLEGEEISYKFTPKYVLRAGQTVTVWAAGAGVAHSPPSTLVWKSQNSWGTGESFRTTLVNADGEEVAMRTVKQSSVVRETENGEEGEDEAAEFGEEDLFHQQGDPRTTSRGCRVM", "length": 628, "header": "tr|F1MJI7-1|F1MJI7_BOVIN Isoform 1 of Lamin-B2 OS=Bos taurus OX=9913 GN=LMNB2 PE=3 SV=2 CANONICAL=F1MJI7-1" }, "locus": { "chromosome": "7", "start_pos": 21151810, "end_pos": 21134201, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018110.8", "url": "https://www.ensembl.org/id/ENSBTAT00000018110.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018110.6", "url": "https://www.ensembl.org/id/ENSBTAP00000018110.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:516326", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:516326", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZLC1-1", "protein_name": "Lamin B2", "gene_name": "Lmnb2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAPDPGSSADPPAAATAMASLPPRAGSATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDKLLLRISEKEEVTTREVSGIKTLYESELADARRVLDETARERARLQIEIGKVQAELEEAKKSAKKREGELTVARGRVKDLESLFHRSEAELAAALGDKHVLETEVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENHCQSLQEELAFSKSVFEEEVQETRRRHERHLVEVDSSRQQEYDFKIAQALEELRSQHDEQVRLYRLELEQTYQAKLDNTKLISDQNDKAARAAREELKEARMRVESLSYQLSGLQKQASAAEDHIRELEEALAGERDKFRNMLDAKEQEMAEVRDAMQQQLAEYQELLDIKLALDMEICSYRKLLEGEEERLKLSPSPSSRVTISLATSSSSSSSSSGVGMSLGRGRSKRQRLETEDTPGSPSSASSVSSGSRLAQQAGATGVVNIDEVDLEGRFVRLKNSSDKVSMGQGGRTGTPFLVAGGSKACLGCRINLWGTGGSRNRFWRVRTSPTSSHPSMSCEPARRSRCGQLAQGLHTAPHQPLCGRTRAAGGLGRTSAPSWSMRTARRWPCRLQSRHLSRGTRAGRRRKRQRQSLVKRTFSTSRGTQGLPQGAAG", "length": 640 }, "evidence": [ { "id": "F1MJI7", "url": "https://omabrowser.org/oma/group/F1MJI7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P21619-1", "protein_name": "Lamin-B2", "gene_name": "Lmnb2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASLPPHAGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLRISEKEEVTTREVSGIKTLYESELADARRVLDETARERARLQIEIGKVQAELEEARKSAKKREGELTVAQGRVKDLESLFHRSEAELATALSDKQGLETEVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELAFSKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEDLRSQHDEQVRLYRVELEQTYQAKLDNAKLLSDQNDKAAHAAREELKEARMRVESLSYQLLGLQKQASAAENHIHELEEALAGERDKFRKMLDAKEQEMTEVRDAMQQQLAEYQELLDIKLALDMEISAYRKLLEGEEERLKLSPSPSSRITISRATSSSSSSSGVGMSVGQGRGKRRRLETEDTSGSPSRASRVSSGSRLAQQTVATGVVNIDEVDPEGRFVRLKNSSDKDQSLGNWRIKRQVLEGEDIAYKFTPKYVLRAGQTVTVWAAGAGATHSPPSTLVWKSQTNWGPGESFRTALVSADGEEVAVKAAKHSSVQGRENGEEEEEEEAEFGEEDLFHQQGDPRTTSRGCRLM", "length": 596 }, "evidence": [ { "id": "F1MJI7", "url": "https://omabrowser.org/oma/group/F1MJI7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q03252-1", "protein_name": "Lamin-B2", "gene_name": "LMNB2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSPPSPGRRREQRRPRAAATMATPLPGRAGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRGCYVM", "length": 620 }, "evidence": [ { "id": "F1MJI7", "url": "https://omabrowser.org/oma/group/F1MJI7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "protein localization to nuclear envelope", "id": "GO:0090435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090435", "evidence": [ { "database": "UniProtKB", "id": "F1MJI7", "url": "https://www.uniprot.org/uniprotkb/F1MJI7" } ], "pmid": "" }, { "name": "nuclear envelope organization", "id": "GO:0006998", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006998", "evidence": [ { "database": "UniProtKB", "id": "F1MJI7", "url": "https://www.uniprot.org/uniprotkb/F1MJI7" } ], "pmid": "" }, { "name": "heterochromatin formation", "id": "GO:0031507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031507", "evidence": [ { "database": "UniProtKB", "id": "F1MJI7", "url": "https://www.uniprot.org/uniprotkb/F1MJI7" } ], "pmid": "" }, { "name": "nuclear migration", "id": "GO:0007097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007097", "evidence": [ { "database": "UniProtKB", "id": "F1MJI7", "url": "https://www.uniprot.org/uniprotkb/F1MJI7" } ], "pmid": "" }, { "name": "nuclear pore localization", "id": "GO:0051664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051664", "evidence": [ { "database": "UniProtKB", "id": "F1MJI7", "url": "https://www.uniprot.org/uniprotkb/F1MJI7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "structural constituent of cytoskeleton", "id": "GO:0005200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", "evidence": [ { "database": "UniProtKB", "id": "F1MJI7", "url": "https://www.uniprot.org/uniprotkb/F1MJI7" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1MJI7", "url": "https://www.uniprot.org/uniprotkb/F1MJI7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "F1MJI7", "url": "https://www.uniprot.org/uniprotkb/F1MJI7" } ], "pmid": "" }, { "name": "intermediate filament", "id": "GO:0005882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005882", "evidence": [ { "database": "UniProtKB", "id": "F1MJI7", "url": "https://www.uniprot.org/uniprotkb/F1MJI7" } ], "pmid": "" }, { "name": "nuclear lamina", "id": "GO:0005652", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005652", "evidence": [ { "database": "UniProtKB", "id": "F1MJI7", "url": "https://www.uniprot.org/uniprotkb/F1MJI7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 497, "end_pos": 499, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJI7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 628, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJI7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJI7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJI7" }, { "id": "PS51842", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51842" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IF rod", "eco_id": "ECO_0000259", "start_pos": 50, "end_pos": 406, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJI7" }, { "id": "PS51841", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51841" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LTD", "eco_id": "ECO_0000259", "start_pos": 469, "end_pos": 586, "start_aa": "Phe", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 497, "end_pos": 499 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJI9-1", "uniprot_ac": "F1MJI9", "uniprot_id": "F1MJI9_BOVIN", "mass": { "chemical_mass": 57788.0, "monoisotopic_mass": 57788.0 }, "refseq": {}, "gene_names": [ { "name": "ZNF18", "type": "recommended", "evidence": [ { "id": "F1MJI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJI9" } ] } ], "protein_names": [ { "name": "Zinc finger protein 18", "type": "synonym", "evidence": [ { "id": "F1MJI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJI9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May be involved in transcriptional regulation.", "evidence": [ { "database": "UniProtKB", "id": "F1MJI9", "url": "https://www.uniprot.org/uniprotkb/F1MJI9#function" }, { "database": "UniProtKB", "id": "ARBA00003767", "url": "https://www.uniprot.org/uniprotkb/ARBA00003767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJI9", "url": "https://www.uniprot.org/uniprotkb/F1MJI9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZNF18", "url": "https://www.uniprot.org/uniprotkb/F1MJI9", "locus": { "chromosome": "19", "start_pos": 30615621, "end_pos": 30640005, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004675", "url": "https://www.ensembl.org/id/ENSBTAG00000004675" } ] } } ], "crossref": [ { "id": "F1MJI9", "url": "https://alphafold.ebi.ac.uk/entry/F1MJI9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004675", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004675", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07765", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07765", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036051", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036051", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MJI9", "url": "https://www.orthodb.org/?gene=F1MJI9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23226:SF190", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23226:SF190", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-212436", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MJI9", "url": "https://www.uniprot.org/uniprotkb/F1MJI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJI9-1", "url": "https://www.uniprot.org/uniprotkb/F1MJI9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMPVELGQAPVLLPPPAKAKELLFPGPDATPRGEPSSPETARQLFRQFPYQVMSGPHETLQQLRKLCFQWLQPEVHTKEQILEMLMLEQFLSILPGEIQTWVRKQCPGSGEEAVTLVESLKGDPQRLWQWISIQVLGQEVFSEKAEPASCPAGDAGSPAEEPQKLGLQNTAPGPGEPLSCVVKEESDMEQGLAAAATQLSAQLPAQPEQMPVRDQDFRASLLHTASQWRHLDSTQKEQYWDLMLETYGKMVSGGAGISSARPDLTDPAGYGVELAGPHLQANEKIPRPTCIGDRGENDKENLNLENYRAQDPPALGEPPPQAPLSGLFSEDEPRPFGEGEDLSEAQGNLRGEGTGGQLCPQERNSRKQPGPHLLPPLPGDSPAPWPEEKREAALRGQPRAPMAQRLPTCRECGKTFYRNSQLVFHQRTHSRETYFQCPTCQKAFLRSSSFMKHQRIHTGEKPCKCDYCGKGFSDFSGLRYHKKIHTGEKPYKCTRCGKSFSWSSSLDKHQRSHLGKKPRP", "length": 520, "header": "tr|F1MJI9-1|F1MJI9_BOVIN Isoform 1 of Zinc finger protein 18 OS=Bos taurus OX=9913 GN=ZNF18 PE=3 SV=4 CANONICAL=F1MJI9-1" }, "isoforms": [ { "isoform_ac": "F1MJI9-1", "url": "https://www.uniprot.org/uniprotkb/F1MJI9/entry", "sequence": { "sequence": "MMPVELGQAPVLLPPPAKAKELLFPGPDATPRGEPSSPETARQLFRQFPYQVMSGPHETLQQLRKLCFQWLQPEVHTKEQILEMLMLEQFLSILPGEIQTWVRKQCPGSGEEAVTLVESLKGDPQRLWQWISIQVLGQEVFSEKAEPASCPAGDAGSPAEEPQKLGLQNTAPGPGEPLSCVVKEESDMEQGLAAAATQLSAQLPAQPEQMPVRDQDFRASLLHTASQWRHLDSTQKEQYWDLMLETYGKMVSGGAGISSARPDLTDPAGYGVELAGPHLQANEKIPRPTCIGDRGENDKENLNLENYRAQDPPALGEPPPQAPLSGLFSEDEPRPFGEGEDLSEAQGNLRGEGTGGQLCPQERNSRKQPGPHLLPPLPGDSPAPWPEEKREAALRGQPRAPMAQRLPTCRECGKTFYRNSQLVFHQRTHSRETYFQCPTCQKAFLRSSSFMKHQRIHTGEKPCKCDYCGKGFSDFSGLRYHKKIHTGEKPYKCTRCGKSFSWSSSLDKHQRSHLGKKPRP", "length": 520, "header": "tr|F1MJI9-1|F1MJI9_BOVIN Isoform 1 of Zinc finger protein 18 OS=Bos taurus OX=9913 GN=ZNF18 PE=3 SV=4 CANONICAL=F1MJI9-1" }, "locus": { "chromosome": "19", "start_pos": 30628058, "end_pos": 30616625, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006133.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006133.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006133.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006133.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MJI9", "url": "https://www.uniprot.org/uniprotkb/F1MJI9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MJI9", "url": "https://www.uniprot.org/uniprotkb/F1MJI9" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MJI9", "url": "https://www.uniprot.org/uniprotkb/F1MJI9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MJI9", "url": "https://www.uniprot.org/uniprotkb/F1MJI9" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1MJI9", "url": "https://www.uniprot.org/uniprotkb/F1MJI9" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1MJI9", "url": "https://www.uniprot.org/uniprotkb/F1MJI9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJI9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 520, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJI9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJI9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJI9" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 407, "end_pos": 434, "start_aa": "Pro", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJI9" }, { "id": "PS50805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "KRAB", "eco_id": "ECO_0000259", "start_pos": 214, "end_pos": 287, "start_aa": "Asp", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJI9" }, { "id": "PS50804", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50804" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SCAN box", "eco_id": "ECO_0000259", "start_pos": 42, "end_pos": 121, "start_aa": "Arg", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJJ9-1", "uniprot_ac": "F1MJJ9", "uniprot_id": "F1MJJ9_BOVIN", "mass": { "chemical_mass": 77708.0, "monoisotopic_mass": 77708.0 }, "refseq": { "ac": "XP_024855916", "name": "SLIT and NTRK-like protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855916" }, "gene_names": [ { "name": "SLITRK1", "type": "recommended", "evidence": [ { "id": "F1MJJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9" } ] }, { "name": "SLITRK1", "type": "synonym", "evidence": [ { "id": "XP_024855916", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855916" } ] } ], "protein_names": [ { "name": "SLIT and NTRK like family member 1", "type": "synonym", "evidence": [ { "id": "F1MJJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9/entry#names_and_taxonomy" } ] }, { "name": "SLIT and NTRK-like protein 1", "type": "synonym", "evidence": [ { "id": "XP_024855916", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855916" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJJ9", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLITRK1", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9", "locus": { "chromosome": "12", "start_pos": 58781141, "end_pos": 59341809, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000038168", "url": "https://www.ensembl.org/id/ENSBTAG00000038168" } ] } } ], "crossref": [ { "id": "ENSBTAG00000038168", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038168", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "615880", "url": "https://www.ncbi.nlm.nih.gov/gene/615880", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:615880", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615880", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KICACNE", "url": "https://omabrowser.org/oma/group/KICACNE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MJJ9", "url": "https://www.orthodb.org/?gene=F1MJJ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45773", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45773", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45773:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45773:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-388844", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-388844", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024855916", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855916", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MJJ9", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJJ9-1", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKHRVDSSLPAPPAQEETFPPGPLPTPFKTNGQEDHATPGSAPNGGTKIPGNWQIKIRPTAAIGTGSARNKPPANGLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADGAHRVYDCGSHSLSD", "length": 696, "header": "tr|F1MJJ9-1|F1MJJ9_BOVIN Isoform 1 of SLIT and NTRK like family member 1 OS=Bos taurus OX=9913 GN=SLITRK1 PE=3 SV=2 CANONICAL=F1MJJ9-1" }, "isoforms": [ { "isoform_ac": "F1MJJ9-1", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9/entry", "sequence": { "sequence": "MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKHRVDSSLPAPPAQEETFPPGPLPTPFKTNGQEDHATPGSAPNGGTKIPGNWQIKIRPTAAIGTGSARNKPPANGLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADGAHRVYDCGSHSLSD", "length": 696, "header": "tr|F1MJJ9-1|F1MJJ9_BOVIN Isoform 1 of SLIT and NTRK like family member 1 OS=Bos taurus OX=9913 GN=SLITRK1 PE=3 SV=2 CANONICAL=F1MJJ9-1" }, "locus": { "chromosome": "12", "start_pos": 58784982, "end_pos": 58782895, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132214.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132214.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100640.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100640.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 288, "start_aa": "Thr", "end_pos": 288, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr288", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 322, "start_aa": "Thr", "end_pos": 322, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr322", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:615880", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615880", "resource": "KEGG Pathway" }, { "id": "R-BTA-388844", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-388844", "resource": "Reactome", "description": "Receptor-type tyrosine-protein phosphatases" } ], "orthologs": [ { "uniprot_canonical_ac": "D3Z8D8-1", "protein_name": "SLIT and NTRK-like family, member 1", "gene_name": "Slitrk1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKINGQDEHATPGAVPNGGTKIPGNWQLKIKPTPPIATGSARNKPPVHGLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRRSHFVDYKNLILLDLGNNNIANIENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYAKISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADGAHRVYDCGSHSLSD", "length": 696 }, "evidence": [ { "id": "F1MJJ9", "url": "https://omabrowser.org/oma/group/F1MJJ9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NZH0-1", "protein_name": "SLIT and NTRK like family member 1", "gene_name": "SLITRK1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLLWILLLETSLCFAAGNVTGDVCKEKICACNEIEGDLHVDCEKKGFTSLQHFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFRDLNKLEVLILNDNLISTLPPNVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVICEAPTRLQGKDLNETTEQELCKKNRVDSSLAAPPAEEETCDPGPIPTPFKIHGKEDPATPGSGPNGGTKIPVNWQIKTRPTAAVSTVSVKSKQPAILSCPQICSCDQIPGSGLKVNCNDRNVSSLVDLKPKPSNVQELFLRDNKIHTIRKSHFLDYRKLNLLDLGNNNIATVENNTFKNLFDLRWLYMDSNYLDTLSREKFTGLQNLEYLNVEFNGIQLIMPGTFNAMPKLRVLILNNNLLRSLPVDVFAGVSLSKLSIHNNYFMYLPVAGVLDQLTSITQIDLHGNPWDCTCPIVPFKQWAEMLRPKVIMSDLRCESPEDFFKEDFESLSNDVICPQLKISPTLSSTNKNSTGVAETGTHSNSYLETSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYSTDGAHRVYDCGSHSLSD", "length": 692 }, "evidence": [ { "id": "F1MJJ9", "url": "https://omabrowser.org/oma/group/F1MJJ9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { 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], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q810C1-1", "protein_name": "SLIT and NTRK-like protein 1", "gene_name": "Slitrk1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQDEHATPGAVPNGGTKIPGNWQLKIKPTPPIATGSARNKPPVHGLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIANIENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNEEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADGSHRVYDCGSHSLSD", "length": 696 }, "evidence": [ { "id": "F1MJJ9", "url": "https://omabrowser.org/oma/group/F1MJJ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96PX8-1", "protein_name": "SLIT and NTRK-like protein 1", "gene_name": "SLITRK1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQEDHATPGSAPNGGTKIPGNWQIKIRPTAAIATGSSRNKPLANSLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADGAHRVYDCGSHSLSD", "length": 696 }, "evidence": [ { "id": "F1MJJ9", "url": "https://omabrowser.org/oma/group/F1MJJ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "F1MJJ9", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9" } ], "pmid": "" }, { "name": "GABA-ergic synapse", "id": "GO:0098982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982", "evidence": [ { "database": "UniProtKB", "id": "F1MJJ9", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9" } ], "pmid": "" }, { "name": "postsynaptic density membrane", "id": "GO:0098839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098839", "evidence": [ { "database": "UniProtKB", "id": "F1MJJ9", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "axonogenesis", "id": "GO:0007409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007409", "evidence": [ { "database": "UniProtKB", "id": "F1MJJ9", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9" } ], "pmid": "" }, { "name": "synapse assembly", "id": "GO:0007416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007416", "evidence": [ { "database": "UniProtKB", "id": "F1MJJ9", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9" } ], "pmid": "" }, { "name": "positive regulation of synapse assembly", "id": "GO:0051965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051965", "evidence": [ { "database": "UniProtKB", "id": "F1MJJ9", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9" } ], "pmid": "" }, { "name": "positive regulation of axonogenesis", "id": "GO:0050772", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050772", "evidence": [ { "database": "UniProtKB", "id": "F1MJJ9", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9" } ], "pmid": "" }, { "name": "synaptic membrane adhesion", "id": "GO:0099560", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099560", "evidence": [ { "database": "UniProtKB", "id": "F1MJJ9", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9" } ], "pmid": "" }, { "name": "regulation of presynapse assembly", "id": "GO:1905606", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905606", "evidence": [ { "database": "UniProtKB", "id": "F1MJJ9", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 18, "end_pos": 20, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" }, { "start_pos": 416, "end_pos": 418, "annotation": "n_glycosylation_sequon" }, { "start_pos": 595, "end_pos": 597, "annotation": "n_glycosylation_sequon" }, { "start_pos": 655, "end_pos": 657, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJJ9" }, { "id": "SM00082", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00082" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "LRRCT", "eco_id": "ECO_0000259", "start_pos": 212, "end_pos": 262, "start_aa": "Asn", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 288, 322 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 18, "end_pos": 20 }, { "start_pos": 253, "end_pos": 255 }, { "start_pos": 363, "end_pos": 365 }, { "start_pos": 416, "end_pos": 418 }, { "start_pos": 595, "end_pos": 597 }, { "start_pos": 655, "end_pos": 657 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJK3", "url": "https://www.uniprot.org/uniprotkb/F1MJK3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC506828", "url": "https://www.uniprot.org/uniprotkb/F1MJK3", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000038461", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000038461", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02897", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02897", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506828", "url": "https://www.ncbi.nlm.nih.gov/gene/506828", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002890", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002890", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011625", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011625", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", 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"https://www.ebi.ac.uk/interpro/entry/IPR050473", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506828", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506828", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR11412", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11412", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11412:SF116", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11412:SF116", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00207", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00207", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01835", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01835", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07677", "url": 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] }, { "id": "F1MJK3-1", "url": "https://www.uniprot.org/uniprotkb/F1MJK3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGHQLPNPVLILLFLLLPRDASATSKPQYLVLVPSQLYAGVPEKVCVLLNHLNETVALTVTLESETEGRNLLTDLEAKNSFYCSSFTIPDSFPFAFITVQVQGPTQNFIKKKPIYITKAESLVFVQTDKPIYKPGQTVQFRIFSVDVNFHPLNETFLVVYIENPKRNRIFQWPSFKLQGGLSQLSFPLSVEPALGPYKVVLLKEPGKRIEHSFEVDEYVLPKFEVQVKMPKKISFLEDEFEVSVCSLYTYGKPVRGLVTINVCRKYLQYSSSCNGKYPKSICEEFSQQADDEGCFTQLVNAKSLQLKQKGYERTLQVEAKVREEGTGLELTGHGSSEITNTLSKLKFTKVHSHYRRGLPFFGQVLLVNEKDQPIPNETVVVNVDMFQYSARFTTNEHGLVNFSIDTSNFTSSFISVGVIYKQNSHCFDSRWLEESHIPATHTASHIFSPSKSYIQLEPVADTVICGKTQEIRVHYILNGQILTDERELTFYYLIKARGSIAQSETHVLSIKQGELKGVFSFSFRVESDIAPIAQLLVYTILPNGEVIADTEELDIENCFANKVNLSFSSAQGLPASNTSLKITAAPYSLCGLRAVDKSVLLMKPEAEFSPQSVYNLLSVKKIFSMGYRGPMNEDREKCINAEDITHNGIIYIPKQFISDDDAYSIFESVGLNIFTNSKIHKPHFCQPLPYPGMSMNYGAPGLASSRSLPGPIHGMATPLAGIDARGVYPSSSREDSSAMKVKETIRKYFPETWIWELIPLDMWGKHELAIKVPDTITEWKASALCLSGTAGLGLSPTISLTAFQPFFLELTLPYSVVRGEAFTLKATVFNYLSHCIRVSIQLEASSAFLAIPVEKNEESQCVCGNKQRTVSWAVTPKSLGEVNFTATAEALRSQELCGNKVPHFPEIGQKDTVIKPLLVEPEGIEREETFNTLLCASETGGSEKLSLKLPSNVVEGSARATYSVLGDILGSAMQNLQNLLRMPYGCGEQNMVLFTPNIYVLNYLNETGQLTEKIKSKAISYLISGYQRQLNYKHSDGSYSTFGDRDGRSQGNTWLTAFVLKSFSQAQSHIFVEDSHITDSLTWLSRKQKENGCFQRSGSLLNNAIKGGVDDEVTLSAYITIALLEMPLLVTHSIVRNALFCLERAWQSASEAQGSFVYTKALLAYAFALAGDQAKRNELLESLHKEAVKEEDSIHWQRPRKPQEVNELYSPHRAPSVDVEMTSYCLLAHLTAQPAPSSEDLSVATQIVKWLTKQQNPNGGFSSTQDTVVALQALSKYGAATFIKGEKAATVTVKSAGTFSEEFQVDEAKRLLLQEVALPEIPGKYSTAVTGSGCVYIQTSLRYNILPKKEGKAPFTLKVETLPKNCDGVSTHRKVQIHVNISYTGERPSSNMVIVDVKMVSGFIPVKSSVRKLQEMAQIQRTEVSTNHVLIYFEELTHHILSFFFSVEQDIAVKNLKPATIKAYDYYETEEFTIEEYSVPCSAESEHGND", 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"length": 1491, "header": "tr|F1MJK3-1|F1MJK3_BOVIN Isoform 1 of Pregnancy zone protein OS=Bos taurus OX=9913 GN=LOC506828 PE=3 SV=4 CANONICAL=F1MJK3-1" }, "locus": { "chromosome": "5", "start_pos": 100811582, "end_pos": 100755589, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037743.7", "url": "https://www.ensembl.org/id/ENSBTAT00000037743.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037567.6", "url": "https://www.ensembl.org/id/ENSBTAP00000037567.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 876, "start_aa": "Thr", "end_pos": 876, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr876", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:506828", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506828", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protease binding", "id": "GO:0002020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002020", "evidence": [ { "database": "UniProtKB", "id": "F1MJK3", "url": "https://www.uniprot.org/uniprotkb/F1MJK3" } ], "pmid": "" }, { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "F1MJK3", "url": "https://www.uniprot.org/uniprotkb/F1MJK3" } ], "pmid": "" }, { "name": "endopeptidase inhibitor activity", "id": "GO:0004866", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004866", "evidence": [ { "database": "UniProtKB", "id": "F1MJK3", "url": "https://www.uniprot.org/uniprotkb/F1MJK3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1MJK3", "url": "https://www.uniprot.org/uniprotkb/F1MJK3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1006, "end_pos": 1008, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1381, "end_pos": 1383, "annotation": "n_glycosylation_sequon" }, { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 377, "end_pos": 379, "annotation": "n_glycosylation_sequon" }, { "start_pos": 402, "end_pos": 404, "annotation": "n_glycosylation_sequon" }, { "start_pos": 409, "end_pos": 411, "annotation": "n_glycosylation_sequon" }, { "start_pos": 54, "end_pos": 56, "annotation": "n_glycosylation_sequon" }, { "start_pos": 565, "end_pos": 567, "annotation": "n_glycosylation_sequon" }, { "start_pos": 578, "end_pos": 580, "annotation": "n_glycosylation_sequon" }, { "start_pos": 884, "end_pos": 886, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJK3" }, { "id": "SM01360", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01360" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Alpha-2-macroglobulin", "eco_id": "ECO_0000259", "start_pos": 753, "end_pos": 843, "start_aa": "Thr", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJK3" }, { "id": "SM01359", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01359" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Alpha-2-macroglobulin bait region", "eco_id": "ECO_0000259", "start_pos": 455, "end_pos": 603, "start_aa": "Ile", "end_aa": "Met", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJK3" }, { "id": "SM01361", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01361" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Alpha-macroglobulin receptor-binding", "eco_id": "ECO_0000259", "start_pos": 1391, "end_pos": 1478, "start_aa": "Ser", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 876 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1006, "end_pos": 1008 }, { "start_pos": 1381, "end_pos": 1383 }, { "start_pos": 154, "end_pos": 156 }, { "start_pos": 377, "end_pos": 379 }, { "start_pos": 402, "end_pos": 404 }, { "start_pos": 409, "end_pos": 411 }, { "start_pos": 54, "end_pos": 56 }, { "start_pos": 565, "end_pos": 567 }, { "start_pos": 578, "end_pos": 580 }, { "start_pos": 884, "end_pos": 886 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MGR9-1", "uniprot_ac": "F1MGR9", "uniprot_id": "F1MGR9_BOVIN", "mass": { "chemical_mass": 99220.0, "monoisotopic_mass": 99220.0 }, "refseq": { "ac": "XP_002692403", "name": "nuclear factor of activated T-cells, cytoplasmic 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692403" }, "gene_names": [ { "name": "NFATC2", "type": "recommended", "evidence": [ { "id": "F1MGR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGR9" } ] }, { "name": "NFATC2", "type": "synonym", "evidence": [ { "id": "XP_002692403", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692403" } ] } ], "protein_names": [ { "name": "Nuclear factor of activated T-cells, cytoplasmic 1", "type": "recommended", "evidence": [ { "id": "F1MGR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGR9/entry#names_and_taxonomy" } ] }, { "name": "NFAT transcription complex cytosolic component", "type": "synonym", "evidence": [ { "id": "F1MGR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGR9/entry#names_and_taxonomy" } ] }, { "name": "nuclear factor of activated T-cells, cytoplasmic 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002692403", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692403" } ] } ], "function": [ { "annotation": "Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LMQ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMQ6#function" }, { "database": "UniProtKB", "id": "ARBA00058891", "url": "https://www.uniprot.org/uniprotkb/ARBA00058891#function" }, { "database": "UniProtKB", "id": "F1MGR9", "url": "https://www.uniprot.org/uniprotkb/F1MGR9#function" }, { "database": "UniProtKB", "id": "A0A3Q1N525", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N525#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MGR9", "url": "https://www.uniprot.org/uniprotkb/F1MGR9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NFATC2", "url": "https://www.uniprot.org/uniprotkb/F1MGR9", "locus": { "chromosome": "13", "start_pos": 79244982, "end_pos": 79401870, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018270", "url": "https://www.ensembl.org/id/ENSBTAG00000018270" } ] } } ], "crossref": [ { "id": "F1MGR9", "url": "https://alphafold.ebi.ac.uk/entry/F1MGR9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018270", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018270", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01178", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01178", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd07881", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07881", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530401", "url": "https://www.ncbi.nlm.nih.gov/gene/530401", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011539", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011539", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037059", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037059", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530401", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530401", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PAIPICX", "url": "https://omabrowser.org/oma/group/PAIPICX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LMQ6", "url": "https://www.orthodb.org/?gene=A0A3Q1LMQ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N525", "url": "https://www.orthodb.org/?gene=A0A3Q1N525", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MGR9", "url": "https://www.orthodb.org/?gene=F1MGR9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12533", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12533", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12533:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12533:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00554", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00554", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16179", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16179", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2025928", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2025928", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2871809", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871809", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5607763", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5607763", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002692403", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692403", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMQ6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N525", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N525", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N525-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N525-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGR9", "url": "https://www.uniprot.org/uniprotkb/F1MGR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MGR9-1", "url": "https://www.uniprot.org/uniprotkb/F1MGR9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDAPEPQPDPDGGDAPGHEPGDSPQDEFDFSILFDYDYLNPIEEEPSAHKVASPPSGLYPDDVLDYGLKPYSPLASLSGEPPGRLREPDRVGPQNFLSPAKPPGASGLSPRIEITPSHELIQAGGPFRVRDTGLLGEQPPPPGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTGLAEDSCLGRHSPVPRPASRSSSPGTKRRHSCAGASVAPLPAASPQRSRSPSPQPRDDGVPAGYPPSAGPAALMDALNSLAGDSPCGIPPKMWKTSPDPSPVSAAPPKAGLPRHLYPAVEFLGPCEQEERRNSAPESILLVPPTWPKQLVPAIPICSIPVTASLPPLEWPLSHQSGAYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPEASGRIVSLQTASNPIECSQRSAHELPMVERQDIDSCLVYGGQQMILTGQNFTAESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTSVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPALICSPAHGGLGSQPYYAQHPMVAEPPSCLVATMAPCQQFRSGLSSPDARYQQQNPAAVLYQRSKSLSPGLLGYQQPALMASPLALADAHRSVLVHAGSQGQGAALLHSGPANQQASPVIHYSPTNQPLRCGSHQEFQHIVYCENFAPGPARPGPPPVSQGQRLSPGSYPTVIQQQNAPSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDVNEIIRKEFSGPPVRNQT", "length": 918, "header": "tr|F1MGR9-1|F1MGR9_BOVIN Isoform 1 of Nuclear factor of activated T-cells, cytoplasmic 1 OS=Bos taurus OX=9913 GN=NFATC2 PE=4 SV=3 CANONICAL=F1MGR9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LMQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMQ6/entry", "sequence": { "sequence": "MEVAIQPQLRAHRGSGLQEKAVGAPPPAPTLLVSAGHPGQKDKWLSHPDPGSGRAAELRRGGWKRRLRPSAWQVASRGAGRCGRDQGRPASSRPSPPSPVPGCRPAPPAGPRCPRLPSPGCNRCLRSRKRAPPPLSSPGRAIPGPRVCPHEDSDPAAPPASPPRFLLPSPSPARGPRVHRARLRPRPAARPPAAPRAMDAPEPQPDPDGGDAPGHEPGDSPQDEFDFSILFDYDYLNPIEEEPSAHKVASPPSGLYPDDVLDYGLKPYSPLASLSGEPPGRLREPDRVGPQNFLSPAKPPGASGLSPRIEITPSHELIQAGGPFRVRDTGLLGEQPPPPGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTGLAEDSCLGRHSPVPRPASRSSSPGTKRRHSCAGASVAPLPAASPQRSRSPSPQPRDDGVPAGYPPSAGPAALMDALNSLAGDSPCGIPPKMWKTSPDPSPVSAAPPKAGLPRHLYPAVEFLGPCEQEERRNSAPESILLVPPTWPKQLVPAIPICSIPVTASLPPLEWPLSHQSGAYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPEASGRIVSLQTASNPIECSQRSAHELPMVERQDIDSCLVYGGQQMILTGQNFTAESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTSVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPALICSPAHGGLGSQPYYAQHPMVAEPPSCLVATMAPCQQFRSGLSSPDARYQQQNPAAVLYQRSKSLSPGLLGYQQPALMASPLALADAHRSVLVHAGSQGQGAALLHSGPANQQASPVIHYSPTNQPLRCGSHQEFQHIVYCENFAPGPARPGPPPVSQGQRLSPGSYPTVIQQQNAPSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDELIDTHLSWIQNIL", "length": 1111, "header": "tr|A0A3Q1LMQ6-1|A0A3Q1LMQ6_BOVIN Computationally mapped isoform of Nuclear factor of activated T-cells, cytoplasmic 1 OS=Bos taurus OX=9913 GN=NFATC2 PE=4 SV=2 CANONICAL=F1MGR9-1" }, "locus": { "chromosome": "13", "start_pos": 79385207, "end_pos": 79253508, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082305.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082305.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061181.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061181.2" } ] } }, { "isoform_ac": "A0A3Q1N525-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N525/entry", "sequence": { "sequence": "MQREAALRRGHCEPLRAMGSVDQEEPSAHKVASPPSGLYPDDVLDYGLKPYSPLASLSGEPPGRLREPDRVGPQNFLSPAKPPGASGLSPRIEITPSHELIQAGGPFRVRDTGLLGEQPPPPGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTGLAEDSCLGRHSPVPRPASRSSSPGTKRRHSCAGASVAPLPAASPQRSRSPSPQPRDDGVPAGYPPSAGPAALMDALNSLAGDSPCGIPPKMWKTSPDPSPVSAAPPKAGLPRHLYPAVEFLGPCEQEERRNSAPESILLVPPTWPKQLVPAIPICSIPVTASLPPLEWPLSHQSGAYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPEASGRIVSLQTASNPIECSQRSAHELPMVERQDIDSCLVYGGQQMILTGQNFTAESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTSVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPALICSPAHGGLGSQPYYAQHPMVAEPPSCLVATMAPCQQFRSGLSSPDARYQQQNPAAVLYQRSKSLSPGLLGYQQPALMASPLALADAHRSVLVHAGSQGQGAALLHSGPANQQASPVIHYSPTNQPLRCGSHQEFQHIVYCENFAPGPARPGPPPVSQGQRLSPGSYPTVIQQQNAPSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDVNEIIRKEFSGPPVRNQT", "length": 898, "header": "tr|A0A3Q1N525-1|F1MGR9_BOVIN Computationally mapped isoform of Nuclear factor of activated T-cells, cytoplasmic 1 OS=Bos taurus OX=9913 GN=NFATC2 PE=4 SV=2 CANONICAL=F1MGR9-1" }, "locus": { "chromosome": "13", "start_pos": 79401671, "end_pos": 79245986, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067889.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067889.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065098.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065098.2" } ] } }, { "isoform_ac": "F1MGR9-1", "url": "https://www.uniprot.org/uniprotkb/F1MGR9/entry", "sequence": { "sequence": "MDAPEPQPDPDGGDAPGHEPGDSPQDEFDFSILFDYDYLNPIEEEPSAHKVASPPSGLYPDDVLDYGLKPYSPLASLSGEPPGRLREPDRVGPQNFLSPAKPPGASGLSPRIEITPSHELIQAGGPFRVRDTGLLGEQPPPPGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSPIMSPRTGLAEDSCLGRHSPVPRPASRSSSPGTKRRHSCAGASVAPLPAASPQRSRSPSPQPRDDGVPAGYPPSAGPAALMDALNSLAGDSPCGIPPKMWKTSPDPSPVSAAPPKAGLPRHLYPAVEFLGPCEQEERRNSAPESILLVPPTWPKQLVPAIPICSIPVTASLPPLEWPLSHQSGAYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPEASGRIVSLQTASNPIECSQRSAHELPMVERQDIDSCLVYGGQQMILTGQNFTAESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTSVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPTDEYDPALICSPAHGGLGSQPYYAQHPMVAEPPSCLVATMAPCQQFRSGLSSPDARYQQQNPAAVLYQRSKSLSPGLLGYQQPALMASPLALADAHRSVLVHAGSQGQGAALLHSGPANQQASPVIHYSPTNQPLRCGSHQEFQHIVYCENFAPGPARPGPPPVSQGQRLSPGSYPTVIQQQNAPSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDVNEIIRKEFSGPPVRNQT", "length": 918, "header": "tr|F1MGR9-1|F1MGR9_BOVIN Isoform 1 of Nuclear factor of activated T-cells, cytoplasmic 1 OS=Bos taurus OX=9913 GN=NFATC2 PE=4 SV=3 CANONICAL=F1MGR9-1" }, "locus": { "chromosome": "13", "start_pos": 79384616, "end_pos": 79245986, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024318.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024318.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024318.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024318.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:530401", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530401", "resource": "KEGG Pathway" }, { "id": "R-BTA-2025928", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2025928", "resource": "Reactome", "description": "Calcineurin activates NFAT" }, { "id": "R-BTA-2871809", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2871809", "resource": "Reactome", "description": "FCERI mediated Ca+2 mobilization" }, { "id": "R-BTA-5607763", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5607763", "resource": "Reactome", "description": "CLEC7A (Dectin-1) induces NFAT activation" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A0I8-1", "protein_name": "Nuclear factor of activated T-cells 2", "gene_name": "Nfatc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDAPEPQSDPDGGDGPGHEPGGSSQDELDFSILFDYDYLNPIEEPIAHKAISSPSGLAYPDDVLDYGLKPCNPLASLSGEPPGRFGESDSIGFQNFLSPAKPAGASGPSPRIEITPSHELMQAGGALRGRDAGLSPEQPALALAGMAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNAGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVAPLPAASPQRSRSPSPQPSPHVAPQDDGIPAGYPPTAGSAVLMDALNSLATDSPCGIPSKIWKTSPDPTPVSTAPSKAGLARHIYPAVEFLGPCEQEERRNSAPESILLVPPTWPKQLVPAIPICSIPVTASLPPLEWPLSNQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPEPSGRIVSLQAASNPIECSQRSAHELPMVERQDMDSCLVYGGQQMILTGQNFTAESKVVFMEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRVPVKVNFYVINGKRKRSQPQHFTYHPVPAIKTEPSDEYEPSLICSPAHGGLGSQPYYPQHPMLAESPSCLVATMAPCQQFRSGLSSPDARYQQQSPAAALYQRSKSLSPGLLGYQQPSLLAAPLGLADAHRSVLVHAGSQGQGQGQGSTLPHTSSASQQASPVIHYSPTNQQLRGGGHQEFQHIMYCENFGPSSVRPGLPPVNQGQRLSPGSYPTVIQQQTAPSQRAAKNGPPVSDQKEALPSGVTVKQEQNLDQTYLDDVNEIIRKEFSGPPSRNQT", "length": 930 }, "evidence": [ { "id": "F1MGR9", "url": "https://omabrowser.org/oma/group/F1MGR9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1C473-1", "protein_name": "Nuclear factor of activated T cells 2", "gene_name": "NFATC2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAAAQAAEPDPQDGTPGHCPGPGPARDGSPQEEFDFSILFDYDYLKPIEEEPTPHKTNSPPSGVAYAHDVLDCGLKPCPLPFPSLSADPMGRYGQPDSIGTAPTHPASAAGASAPSPRIEITSYPELINSGGPFRSRDTDVLLVEHQSNSATTSPRVTLPVPGFEGYREPLCLSPASSGSSASFISETNLSPCTSPCVSPNNGPSDDLCPQFQNIHTHYSPRTSPIMSPRTSITEETCLGQHSPSPRPNSRSSSPGAKRRYSCTQQPSTSPRQSRTPSPQSSPRIPLREDSSTVTYTQLSSAPLSMDAMNSLPTDPSCAVPTKIWKTSPDPSSMPSHKNSIPCHVFQTVDFHGPCEQEDRRNSAPESILLVPPSWTKQLMPAIPICSLPVQSLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIIGNTKVLEIPLEPKNNMKATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIISLQAASNPIECSQRSAHELPMVERQDIDSCLVYGGQQMILTGQNFTAESKVVFTEKTSDGQQIWEMEATVDKDKSQPSMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPSIKTEPIDDYDPALICNTVHSGLGTVTQPYYSQHTMVTESPSCLVATMAPCQQLRSGLSSPDSRYHQQNPAAVVYQRSKSLSPSQLGYQQSSLMATPVAISDAHRSVLVHTGSPGQTSAVLHHSPGNQQSSPVIHYSPTNQQLRCGSHQEFQHIMCCENFTSSVARPSQPQVSQAQRLSPSSYPTVIQQQTASGQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQAYLDDVNEIIRKEFSGLPARNQT", "length": 927 }, "evidence": [ { "id": "F1MGR9", "url": "https://omabrowser.org/oma/group/F1MGR9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7F9Z5-1", "protein_name": "Nuclear factor of activated T-cells, cytoplasmic 2", "gene_name": "nfatc2a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSSFYGEKAALGLAAELSQVNCQDELEFDYLFEYENQTGLQDEQGISSHSSPPSLSYPPEGVAPYAIKPCASSYVDVHTEGFSAYEQLEAKGYLEHARPNNQALSPRIEITPSRELYNHGQNQLINTSPSPGLTVPGQDPLAYREPQCLSPASSNSSTSWHSENLSPWASPCVSPSNSQLSGDLCPRLQGVHTGSPRTSPGTSPQTTSLSEDACIGPRSPSPRPGSRSTSPLCKRTYEMYTNPNLVPVARSRSPSPHGGHKEHHVNHYISNNGVNGFSVGQAASVPTKIVKTNQQGYPLYSDNHTEGYLLSCEQDMKGKPGPEPFFVIPQIWPKQLVPGMCSIPVSSLPSLEWPLPSRTDQLELHIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLRGYRGKEPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVNGTKVLEIPLEPKNNMKAIIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPQQSGQYLSLQIASHPIECSQRSAHELPMVEKQDMDACSVLGGQQMILTGQNFSADSKVIFMEKTHDGQQIWELEATVDKDKSQASMLFIEVPPYRDPSICHAVKVNFYVINGKRKRSQPQHFTYTPLPVPSIKTEPVDEYESGRMGYSLSQMLGVSPQSYYSPRGVIPPDSLVPGLVPCQQTRLGVSPPDHRFQQQSPAIMYSRTGKSSSSSPIYSQTAATMIPDSHRSVLVHTGSPAQSSHLGSQHPTNQHPSIIQFSPTNHHLLRGGGDPPAPPPPEHQHIIYCEGYNQHGPQPTGANRSPAPAQAAQHPQNYPTVIQQQPFLQRVAKDRSPSAQVEPQRSSSAEEPRANVPGRVTVKQENLDQAYLDDVNEIIRKDLTGVHGRSQT", "length": 894 }, "evidence": [ { "id": "F1MGR9", "url": "https://omabrowser.org/oma/group/F1MGR9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q13469-1", "protein_name": "Nuclear factor of activated T-cells, cytoplasmic 2", "gene_name": "NFATC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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36828497, "end_pos": 37444820, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025589", "url": "https://www.ensembl.org/id/ENSBTAG00000025589" } ] } } ], "crossref": [ { "id": "F1MAW5", "url": "https://alphafold.ebi.ac.uk/entry/F1MAW5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025589", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025589", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01335", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01335", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530159", "url": "https://www.ncbi.nlm.nih.gov/gene/530159", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002792", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002792", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005839", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005839", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013848", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013848", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058240", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058240", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530159", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530159", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HYAYPTG", "url": "https://omabrowser.org/oma/group/HYAYPTG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3S9", "url": "https://www.orthodb.org/?gene=A0A3Q1M3S9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MJ38", "url": "https://www.orthodb.org/?gene=A0A3Q1MJ38", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MAW5", "url": "https://www.orthodb.org/?gene=F1MAW5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11918", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11918", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11918:SF45", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11918:SF45", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00919", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00919", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01938", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01938", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF04055", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04055", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179620", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "37075", "url": "https://www.rhea-db.org/rhea/37075", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M3S9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3S9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3S9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3S9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJ38", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJ38-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXA1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXA1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXA1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MAW5", "url": "https://www.uniprot.org/uniprotkb/F1MAW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MAW5-1", "url": "https://www.uniprot.org/uniprotkb/F1MAW5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSASCDTFLNDIEDIVSQEDSKPQDRHFSRKHVVPKVRRRNTQKYLQEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGKRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGSSLPALLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILHHPRVYAFLHIPVQSASDTVLMEMKREYCVADFKRVVDFLKDKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKELSRIFHSYNPYDHKIGQRQQVLVTEESFDSKFYVAHNRFYEQVLVPKNPTFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLARGEVSGLTEEFRNRLGNHLNSVPHTSAANRRESASSRMVLRLQRLHQDFALKMSVGLALFALLFALLVKVYN", "length": 578, "header": "tr|F1MAW5-1|F1MAW5_BOVIN Isoform 1 of tRNA-t(6)A37 methylthiotransferase OS=Bos taurus OX=9913 GN=CDKAL1 PE=3 SV=4 CANONICAL=F1MAW5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M3S9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3S9/entry", "sequence": { "sequence": "MPSASCDTFLNDIEDIVSQEDSKPQDRHFSRKHVVPKVRRRNTQKYLQEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGKRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGSSLPALLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILHHPRVYAFLHIPVQSASDTVLMEMKREYCVADFKRVVDFLKDKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVVGLDGEVGWSCVFPSEKKQRTKELSRIFHSYNPYDHKIGQRQQVLVTEESFDSKFYVAHNRFYEQVLVPKNPTFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLARGEVSGLTEEFRNRLGNHLNSVPHTSAANRRESASSRMVLRLQRLHQDFALKMSVGLALFALLFALLVKVYN", "length": 594, "header": "tr|A0A3Q1M3S9-1|F1MAW5_BOVIN Computationally mapped isoform of tRNA-t(6)A37 methylthiotransferase OS=Bos taurus OX=9913 GN=CDKAL1 PE=3 SV=2 CANONICAL=F1MAW5-1" }, "locus": { "chromosome": "23", "start_pos": 37436525, "end_pos": 36829258, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085285.2", "url": "https://www.ensembl.org/id/ENSBTAT00000085285.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062862.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062862.2" } ] } }, { "isoform_ac": "A0A3Q1MJ38-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJ38/entry", "sequence": { "sequence": "MPSASCDTFLNDIEDIVSQEDSKPQDRHFSRKHVVPKVRRRNTQKYLQEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGKRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGSSLPALLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILHHPRVYAFLHIPVQSASDTVLMEMKREYCVADFKRVVDFLKDKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKELSRIFHSYNPYDHKIGQRQQVLVTEESFDSKFYVAHNRFYEQVLVPKNPTFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLARGEVSGLTEEFRNRLGNHLNSVPHTSAANRRESASSRMVLRLQRLHQDFALKMSVGLALFALLFALLVKMCYGKVYMETCVWNVSPSGMHRKSLPMKGSWQHFENSEESPPSLITHKLSKTGFV", "length": 630, "header": "tr|A0A3Q1MJ38-1|A0A3Q1MJ38_BOVIN Computationally mapped isoform of Threonylcarbamoyladenosine tRNA methylthiotransferase OS=Bos taurus OX=9913 GN=CDKAL1 PE=3 SV=1 CANONICAL=F1MAW5-1" }, "locus": { "chromosome": "23", "start_pos": 37436525, "end_pos": 36828640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081080.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081080.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070774.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070774.1" } ] } }, { "isoform_ac": "A0AAA9TXA1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXA1/entry", "sequence": { "sequence": "MPSASCDTFLNDIEDIVSQEDSKPQDRHFSRKHVVPKVRRRNTQKYLQEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGKRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGSSLPALLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILHHPRVYAFLHIPVQSASDTVLMEMKREYCVADFKRVVDFLKDKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVIGQRQQVLVTEESFDSKFYVAHNRFYEQVLVPKNPTFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLARGEVSGLTEEFRNRLGNHLNSVPHTSAANRRESASSRMVLRLQRLHQDFALKMSVGLALFALLFALLVKVYN", "length": 557, "header": "tr|A0AAA9TXA1-1|F1MAW5_BOVIN Computationally mapped isoform of tRNA-t(6)A37 methylthiotransferase OS=Bos taurus OX=9913 GN=CDKAL1 PE=3 SV=1 CANONICAL=F1MAW5-1" }, "locus": { "chromosome": "23", "start_pos": 37436525, "end_pos": 36829258, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096163.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096163.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101254.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101254.1" } ] } }, { "isoform_ac": "F1MAW5-1", "url": "https://www.uniprot.org/uniprotkb/F1MAW5/entry", "sequence": { "sequence": "MPSASCDTFLNDIEDIVSQEDSKPQDRHFSRKHVVPKVRRRNTQKYLQEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGKRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGSSLPALLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILHHPRVYAFLHIPVQSASDTVLMEMKREYCVADFKRVVDFLKDKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKELSRIFHSYNPYDHKIGQRQQVLVTEESFDSKFYVAHNRFYEQVLVPKNPTFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLARGEVSGLTEEFRNRLGNHLNSVPHTSAANRRESASSRMVLRLQRLHQDFALKMSVGLALFALLFALLVKVYN", "length": 578, "header": "tr|F1MAW5-1|F1MAW5_BOVIN Isoform 1 of tRNA-t(6)A37 methylthiotransferase OS=Bos taurus OX=9913 GN=CDKAL1 PE=3 SV=4 CANONICAL=F1MAW5-1" }, "locus": { "chromosome": "23", "start_pos": 37436525, "end_pos": 36829258, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017811.7", "url": "https://www.ensembl.org/id/ENSBTAT00000017811.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017811.7", "url": "https://www.ensembl.org/id/ENSBTAP00000017811.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 399, "start_aa": "Thr", "end_pos": 399, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr399", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:530159", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530159", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E1BRH0-1", "protein_name": "tRNA-t(6)A37 methylthiotransferase", "gene_name": "CDKAL1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPAACDSVLEDIEDIVSAQDLKPRDWRFVRKNVFPKVRKRSSQQRAQTDDDPPHDSVIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITDNSAEADLWLLNSCTVKNPAEDHFRNSIKKAQEANKKVVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGKRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGDLASYPIEELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTDLPTLLWKLVEAIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMDMKREYCVADFRRVVDFLKEKVPGITIATDIICGFPGETDEDFQETMKLVEQYKFPSLFINQFYPRPGTPAAKMHQVPAAVKKQRTKDLSQLFHSYNPYDHKVGERQRVLVTEESFDSNYYVAHNPFYEQVLVPKDPALMGKMVEVNIYEAGKHFMKGQPVSDARVYTASITRPLAKGEVSGLKEEFRHAPRNGTKWKAHRSAEIPVKAPLIPWMALHLPWHPEGSGLKILSVSLALLAFLAMVYYGGMKREL", "length": 582 }, "evidence": [ { "id": "F1MAW5", "url": "https://omabrowser.org/oma/group/F1MAW5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1LV76-1", "protein_name": "tRNA-t(6)A37 methylthiotransferase", "gene_name": "Cdkal1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKSSAPQTLYRFIYSLGMHGSQACAVYSTKETNLVLPLQEDFHLPSVRPPALLPACWFENASDADLWLLNSCTVKNPAEDHFRNSIKKAHEENKKVVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKESGKRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVERAKQSFQEGVCEIWLTSEDTGAYGRDIGTDLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMDMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKAKQVPAHVKKQRTKDLSRVFHSYNPYDHKIGERQQVLVTEESFDSKFYVAHNRFYEQVLVPKNPAFMGKMVEVDIYESGKHFLKGQPVSETRVYTPSICKPLAKGEVSGLTTEFRNRLGDRLNSTSGTCPAPPQGSACSRMALQTSQYDCALKVAAGLALIALLLHFWPESMFTM", "length": 542 }, "evidence": [ { "id": "F1MAW5", "url": "https://omabrowser.org/oma/group/F1MAW5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5VV42-1", "protein_name": "Threonylcarbamoyladenosine tRNA methylthiotransferase", "gene_name": "CDKAL1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIYESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAASQCDSASSRMVLPMPRLHQDCALRMSVGLALLGLLFAFFVKVYN", "length": 579 }, "evidence": [ { "id": "F1MAW5", "url": "https://omabrowser.org/oma/group/F1MAW5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q7K4W1-1", "protein_name": "Threonylcarbamoyladenosine tRNA methylthiotransferase", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MYHLGQDLPGNDVDDIEDLISADDVKPRERYENKKTVTVRAKKRSQIRLESQEEEEKPKPTIHESVIPGTQKVFVKTWGCAHNNSDSEYMAGQLAAYGYRLSGKEEADLWLLNSCTVKNPSEDTFRNEIESGMRNGKHVVVAGCVPQGAPKSDYLNGLSVIGVQQIDRVVEVVEETLKGHSVQLLQNKKKVHGRRVAGAPLSLPKVRKNPLIEIISINSGCLNQCTYCKTKHARGDLASYPPEEVVERARQSFAEGCCEIWLTSEDTGAYGRDIGSSLPELLWQLVEVIPEHCMLRVGMTNPPYILEHLEEVANVLQHPRVYSFLHVPVQSGSDSVLGEMKREYCRQDFEHVVDFLRERVPGVTIATDIICGFPTETEDDFEETMTLCAKYRFPSLFINQFFPRPGTPAAKMDRIPANLVKKRTKRLTDLFYSYEPYADRVGEIYTVLVTEVSHDKLHYVGHNKSYEQVLLPMRDNLLGTRVHVRITSASKFSMVGEILDDERDWTRCAKNQELPNVQVQTRSRERLIQRYFGIALVLGSLAFLIQLVVRLL", "length": 552 }, "evidence": [ { "id": "F1MAW5", "url": "https://omabrowser.org/oma/group/F1MAW5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q91WE6-1", "protein_name": "Threonylcarbamoyladenosine tRNA methylthiotransferase", "gene_name": "Cdkal1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPSASCDVLLDDIEDIISQEDSKPQDRQFSRKHVFPKVRRRNTQKYLQEEPRPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKVVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGKRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVERAKQSFQEGVCEIWLTSEDTGAYGRDIGTDLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMDMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKAEQVPAHVKKQRTKDLSRVFHSYNPYDHKIGERQQVLVTEESFDSKFYVAHNRFYEQVLVPKNPAFMGKMVEVDIYESGKHFLKGQPVSETRVYTPSISKPLAKGEVSGLTKEFRNRLGNHPNGTSDTCPATQHGSAYSRMVLQMSQYDCALKVATGLALLALLLHFWPDSLLTM", "length": 578 }, "evidence": [ { "id": "F1MAW5", "url": "https://omabrowser.org/oma/group/F1MAW5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1MAW5", "url": "https://www.uniprot.org/uniprotkb/F1MAW5" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1MAW5", "url": "https://www.uniprot.org/uniprotkb/F1MAW5" } ], "pmid": "" }, { "name": "rough endoplasmic reticulum", "id": "GO:0005791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005791", "evidence": [ { "database": "UniProtKB", "id": "F1MAW5", "url": "https://www.uniprot.org/uniprotkb/F1MAW5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MAW5", "url": 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], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.21.59", "ec_name": "Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.", "evidence": [ { "id": "3.4.21.59", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.21.59" } ] } ], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 115, "end_pos": 117 }, { "start_pos": 186, "end_pos": 188 }, { "start_pos": 206, "end_pos": 208 }, { "start_pos": 253, "end_pos": 255 }, { "start_pos": 312, "end_pos": 314 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMB2-1", "uniprot_ac": "F1MMB2", "uniprot_id": "F1MMB2_BOVIN", "mass": { "chemical_mass": 77012.0, "monoisotopic_mass": 77012.0 }, "refseq": { "ac": "XP_003587853", "name": "rab11 family-interacting protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587853" }, "gene_names": [ { "name": "RAB11FIP3", "type": "recommended", "evidence": [ { "id": "F1MMB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ] }, { "name": "RAB11FIP3", "type": "synonym", "evidence": [ { "id": "XP_003587853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587853" } ] } ], "protein_names": [ { "name": "Rab11 family-interacting protein 3", "type": "recommended", "evidence": [ { "id": "F1MMB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMB2/entry#names_and_taxonomy" } ] }, { "name": "rab11 family-interacting protein 3", "type": "synonym", "evidence": [ { "id": "XP_003587853", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587853" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RAB11FIP3", "url": "https://www.uniprot.org/uniprotkb/F1MMB2", "locus": { "chromosome": "25", "start_pos": 465178, "end_pos": 405140, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016591", "url": "https://www.ensembl.org/id/ENSBTAG00000016591" } ] } } ], "crossref": [ { "id": "F1MMB2", "url": "https://alphafold.ebi.ac.uk/entry/F1MMB2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016591", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016591", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14686", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14686", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511647", "url": "https://www.ncbi.nlm.nih.gov/gene/511647", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019018", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019018", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057316", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057316", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511647", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511647", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NGEHDCR", "url": "https://omabrowser.org/oma/group/NGEHDCR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LHY8", "url": "https://www.orthodb.org/?gene=A0A3Q1LHY8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MMB2", "url": "https://www.orthodb.org/?gene=F1MMB2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15726", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15726", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15726:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15726:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09457", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09457", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25450", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25450", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5620916", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620916", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_003587853", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587853", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LHY8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LHY8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHY8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMB2-1", "url": "https://www.uniprot.org/uniprotkb/F1MMB2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKMEPGRPASPAGGPGPDPEPGGPGAPSAPARSPGLGPQDPAAGVDAGRSPGWERRPQRAGRDPDPDPDPDSDPDLALPELGPFFSWTMEPEGDGPGHSASIRAQDFSRSHHLRGEVDFFPSFAAPEVGDSALELGPGDPDGPSDFSQTHPLTSEPAGCPEDSPRLRAVFDALDGDGDGFVRIEDFVQFATVYGAEQVTDLTRYLDPSGLGVISFEDFYRGIEAIRNGDPDSPLCSVTPAPDEELPACPEEFDDFVTFEANEVTDSAYMGSESTYSECETFTDEDTGTLVPPECLDAAEEPGHGALLLLPGRSHLQGQSVVAVIGGEEHFEDYGEGSEAELSPEILCGGDRGCRDPAFLTPSPAKRLSSKKVARHLQQSGALTMEALQDSPPGPVEGMDEDIADKVVFLEKRVSELEKDTAANGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRKQKELLCKMEREKSIEIENLQARLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIEELSVRLSDEQENRRKLGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLFKLEAEQRRGRSSSAGLQEYHSRTRESELEQEVRRLKQDNRSLKEQNDELNGQIINLSIQGARSLFSTAFSESLAAEISSVSRDELMDAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK", "length": 696, "header": "tr|F1MMB2-1|F1MMB2_BOVIN Isoform 1 of Rab11 family-interacting protein 3 OS=Bos taurus OX=9913 GN=RAB11FIP3 PE=4 SV=2 CANONICAL=F1MMB2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LHY8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LHY8/entry", "sequence": { "sequence": "MKMEPGRPASPAGGPGPDPEPGGPGAPSAPARSPGLGPQDPAAGVDAGRSPGWERRPQRAGRDPDPDPDPDSDPDLALPELGPFFSWTMEPEGDGPGHSASIRAQDFSRSHHLRGEVDFFPSFAAPEVGDSALELGPGDPDGPSDFSQTHPLTSEPAGCPEDSPRLRAVFDALDGDGDGFVRIEDFVQFATVYGAEQVTDLTRYLDPSGLGVISFEDFYRGIEAIRNGDPDSPLCSVTPAPDEELPACPEEFDDFVTFEANEVTDSAYMGSESTYSECETFTDEDTGTLVPPECLDAAEEPGHGALLLLPGRSHLQGQSVVAVIGGEEHFEDYGEGSEAELSPEILCGGDRGCRDPAFLTPSADPLSTKLHSILTDEAFEFYCSQCHRQINRLEDLSARLNDLEKNSPAKRLSSKKVARHLQQSGALTMEALQDSPPGPVEGMDEDIADKVVFLEKRVSELEKDTAANGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRKQKELLCKMEREKSIEIENLQARLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIEELSVRLSDEQENRRKLGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLFKLEAEQRRGRSSSAGLQEYHSRTRESELEQEVRRLKQDNRSLKEQNDELNGQIINLSIQGARSLFSTAFSESLAAEISSVSRDELMDAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK", "length": 741, "header": "tr|A0A3Q1LHY8-1|F1MMB2_BOVIN Computationally mapped isoform of Rab11 family-interacting protein 3 OS=Bos taurus OX=9913 GN=RAB11FIP3 PE=4 SV=1 CANONICAL=F1MMB2-1" }, "locus": { "chromosome": "25", "start_pos": 464174, "end_pos": 405339, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075339.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075339.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058486.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058486.1" } ] } }, { "isoform_ac": "F1MMB2-1", "url": "https://www.uniprot.org/uniprotkb/F1MMB2/entry", "sequence": { "sequence": "MKMEPGRPASPAGGPGPDPEPGGPGAPSAPARSPGLGPQDPAAGVDAGRSPGWERRPQRAGRDPDPDPDPDSDPDLALPELGPFFSWTMEPEGDGPGHSASIRAQDFSRSHHLRGEVDFFPSFAAPEVGDSALELGPGDPDGPSDFSQTHPLTSEPAGCPEDSPRLRAVFDALDGDGDGFVRIEDFVQFATVYGAEQVTDLTRYLDPSGLGVISFEDFYRGIEAIRNGDPDSPLCSVTPAPDEELPACPEEFDDFVTFEANEVTDSAYMGSESTYSECETFTDEDTGTLVPPECLDAAEEPGHGALLLLPGRSHLQGQSVVAVIGGEEHFEDYGEGSEAELSPEILCGGDRGCRDPAFLTPSPAKRLSSKKVARHLQQSGALTMEALQDSPPGPVEGMDEDIADKVVFLEKRVSELEKDTAANGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRKQKELLCKMEREKSIEIENLQARLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIEELSVRLSDEQENRRKLGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLFKLEAEQRRGRSSSAGLQEYHSRTRESELEQEVRRLKQDNRSLKEQNDELNGQIINLSIQGARSLFSTAFSESLAAEISSVSRDELMDAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK", "length": 696, "header": "tr|F1MMB2-1|F1MMB2_BOVIN Isoform 1 of Rab11 family-interacting protein 3 OS=Bos taurus OX=9913 GN=RAB11FIP3 PE=4 SV=2 CANONICAL=F1MMB2-1" }, "locus": { "chromosome": "25", "start_pos": 464174, "end_pos": 405339, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022068.8", "url": "https://www.ensembl.org/id/ENSBTAT00000022068.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022068.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022068.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511647", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511647", "resource": "KEGG Pathway" }, { "id": "R-BTA-5620916", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620916", "resource": "Reactome", "description": "VxPx cargo-targeting to cilium" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z654-1", "protein_name": "Rab11 family-interacting protein 3", "gene_name": "RAB11FIP3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "ARGPFKAGPGGAGLPLGPAPRRGGLSGARRWASDVTARLLRGFAGSADGRAAEEDSGRFGAAAPQHRIASGGADPRGRPPVPPRRAGPAPPRTKPGAGGPPARPPPAPPLDPGPRWDEAGPEADPEPEPESELEAEPGAEPALWAAEPAAGTPPWAPPGRGGCPEDEPRLRPVFDALDRDGDGFVRVEEFVQFATAYGAEQVKELTKYLDPSGLGVISFEDFHRGIRAIRNGDPDSQLYDMGYTPEEEAPACPDEFDDFVTFEANEVTDSAYMGSESTYSECETFTDEDTSTLVHHEMHDEVETDSAIDSTVHSEFTDAIEEQEHGSVGHSIVTVISGEEHFEDYGEGNEADLFSDSLCNGESSFSSSSFLSPRQLHQTSTLSGGAMEESYRDTLECTEEDITDKVVFLEKRVTELEKDTAANGEQHSRLKQENLQLVHRANALEEQLKEQELRADQTLLEEIKKQREMLSKMEREKSIEIENLQARLQQLDDENSELRSCVPCLRANIERLEEEKQKLLDEIEDLTVQLTEEQENKRKMGDKLSHERHQFQKEKESTQELIEDLRKQLEHLQLFKLECEQRRGRSSSMGLQEYNSRTRETELEQEIKQLKQDNRSLKEQNDELNGQIINLSIQGAKNLFSASFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK", "length": 696 }, "evidence": [ { "id": "F1MMB2", "url": "https://omabrowser.org/oma/group/F1MMB2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O75154-1", "protein_name": "Rab11 family-interacting protein 3", "gene_name": "RAB11FIP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASAPPASPPGSEPPGPDPEPGGPDGPGAAQLAPGPAELRLGAPVGGPDPQSPGLDEPAPGAAADGGARWSAGPAPGLEGGPRDPGPSAPPPRSGPRGQLASPDAPGPGPRSEAPLPELDPLFSWTEEPEECGPASCPESAPFRLQGSSSSHRARGEVDVFSPFPAPTAGELALEQGPGSPPQPSDLSQTHPLPSEPVGSQEDGPRLRAVFDALDGDGDGFVRIEDFIQFATVYGAEQVKDLTKYLDPSGLGVISFEDFYQGITAIRNGDPDGQCYGGVASAQDEEPLACPDEFDDFVTYEANEVTDSAYMGSESTYSECETFTDEDTSTLVHPELQPEGDADSAGGSAVPSECLDAMEEPDHGALLLLPGRPHPHGQSVITVIGGEEHFEDYGEGSEAELSPETLCNGQLGCSDPAFLTPSPTKRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK", "length": 756 }, "evidence": [ { "id": "F1MMB2", "url": "https://omabrowser.org/oma/group/F1MMB2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 13, "go_terms": [ { "name": "negative regulation of adiponectin secretion", "id": "GO:0070164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070164", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "positive regulation of mitotic cytokinetic process", "id": "GO:1903438", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903438", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "Golgi to plasma membrane protein transport", "id": "GO:0043001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043001", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "protein localization to cilium", "id": "GO:0061512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061512", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "regulation of cytokinesis", "id": "GO:0032465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032465", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "positive regulation of cilium assembly", "id": "GO:0045724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045724", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "regulation of endocytic recycling", "id": "GO:2001135", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001135", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "regulation of protein localization to centrosome", "id": "GO:1904779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904779", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "early endosome to recycling endosome transport", "id": "GO:0061502", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061502", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "regulation of early endosome to recycling endosome transport", "id": "GO:1902954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902954", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "protein localization to cleavage furrow", "id": "GO:1905345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905345", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "trans-Golgi network membrane", "id": "GO:0032588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032588", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "endocytic vesicle membrane", "id": "GO:0030666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030666", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "cleavage furrow", "id": "GO:0032154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032154", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "endocytic vesicle", "id": "GO:0030139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030139", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" }, { "name": "dynein light intermediate chain binding", "id": "GO:0051959", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051959", "evidence": [ { "database": "UniProtKB", "id": "F1MMB2", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 614, "end_pos": 616, "annotation": "n_glycosylation_sequon" }, { "start_pos": 630, "end_pos": 632, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MMB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 161, "end_pos": 196, "start_aa": "Glu", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MMB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMB2" }, { "id": "PS51511", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51511" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FIP-RBD", "eco_id": "ECO_0000259", "start_pos": 634, "end_pos": 696, "start_aa": "Gln", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 614, "end_pos": 616 }, { "start_pos": 630, "end_pos": 632 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", 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"sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MNM2-1", "uniprot_ac": "F1MNM2", "uniprot_id": "F1MNM2_BOVIN", "mass": { "chemical_mass": 95557.0, "monoisotopic_mass": 95557.0 }, "refseq": {}, "gene_names": [ { "name": "GPLD1", "type": "recommended", "evidence": [ { "id": "F1MNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ] } ], "protein_names": [ { "name": "Phosphatidylinositol-glycan-specific phospholipase D", "type": "recommended", "evidence": [ { "id": "F1MNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNM2/entry#names_and_taxonomy" } ] }, { "name": "3.1.4.50", "type": "synonym", "evidence": [ { "id": "F1MNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNM2/entry#names_and_taxonomy" } ] }, { "name": "Glycoprotein phospholipase D", "type": "synonym", "evidence": [ { "id": "F1MNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNM2/entry#names_and_taxonomy" } ] }, { "name": "Glycosyl-phosphatidylinositol-specific phospholipase D", "type": "synonym", "evidence": [ { "id": "F1MNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNM2/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Hydrolyzes the inositol phosphate linkage of glycosylphosphatidylinositol (GPI)-anchored membrane proteins, thereby releasing them from the cell surface. Cleaves on the inositol side of the anchor, leaving the phosphate group attached to the membrane. This release of GPI-anchored proteins can modulate diverse biological processes, including the activation of signaling pathways.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MEX6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEX6#function" }, { "database": "UniProtKB", "id": "ARBA00094392", "url": "https://www.uniprot.org/uniprotkb/ARBA00094392#function" }, { "database": "UniProtKB", "id": "A0AAA9TA69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA69#function" }, { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPLD1", "url": "https://www.uniprot.org/uniprotkb/F1MNM2", "locus": { "chromosome": "23", "start_pos": 33268597, "end_pos": 33207981, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004982", "url": "https://www.ensembl.org/id/ENSBTAG00000004982" } ] } } ], "crossref": [ { "id": "F1MNM2", "url": "https://alphafold.ebi.ac.uk/entry/F1MNM2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004982", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004982", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013517", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013517", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029002", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029002", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LW12", "url": "https://www.orthodb.org/?gene=A0A3Q1LW12", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MEX6", "url": "https://www.orthodb.org/?gene=A0A3Q1MEX6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MNM2", "url": "https://www.orthodb.org/?gene=F1MNM2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23221", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23221", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23221:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23221:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00882", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00882", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01839", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01839", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "86263", "url": "https://www.rhea-db.org/rhea/86263", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LW12", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LW12-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEX6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEX6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA69", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA69-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNM2-1", "url": "https://www.uniprot.org/uniprotkb/F1MNM2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MITCPIALVAAEAEEAGQPDICAEKMQEKSTLVRFWSGLLMLLGFLCPRSSPCGISTHIEIGHRALEFLHLQDGSINYKELLLRHQDAYQAGSVFPDSFYPSICERGQFHDVSESTHWTPFLNASVHYIRKNYPLPWDEDTEKLVAFLFGITSHMVADVNWHSLGIEQGFLRTMAAIDFHNSYPEAHPAGDFGGDVLSQFEFKFNYLSRHWYVPAEDLLGIYKELYGRVVITKKAIVDCSYLQFLEMYAEMLAISKLYPTYSVKSPFLVEQFQEYFLGGLEDMAFWSTNIYHLTSYMLKNGTSNCNLPENPLFITCGGQQNNTHGSKVQKNGFHKNVTAALTKNIGKHINYTKRGVFFSVDSWTMDSLSFMYKSLERSIREMFIGSSQPLTHVSSPSASYYLSFPYTRLGWAMTSADLNQDGYGDLVVGAPGYSHPGRIHVGRVYLIYGNDLGLPPVDLDLDKEAHEILEGFQPSGRFGSAVAVLDFNVDGVPDLAVGAPSVGSEKLTYTGAVYVYFGSKQGQLSSSPNVTISCQDTYCNLGWTLLAADVNGDSEPDLVIGSPFAPGGGKQKGIVAAFYSGSSYSSQEKLNVEAANWMVKGEEDFAWLGYSLHGVNVNNRTLLLAGSPTWKDTSSQGHLFRTRDEKQSPGRVYGYFPPICQSWFTISGDKAMGKLGTSLSSGHVMVNGTRTQVLLVGAPTQDVVSKVSFLTMTLHQGGSTRMYELTPDSQPSLLSTFSGNRRFSRFGGVLHLSDLDNDGSDEIIVAAPLRITDATAGLMGEEDGRVYVFNGKQITVGDVTGKCKSWVTPCPEEKAQYVLISPEAGSRFGSSVITVRSKEKNQVIIAAGRSSLGARLSGVLHIYRLGQD", "length": 868, "header": "tr|F1MNM2-1|F1MNM2_BOVIN Isoform 1 of Phosphatidylinositol-glycan-specific phospholipase D OS=Bos taurus OX=9913 GN=GPLD1 PE=3 SV=3 CANONICAL=F1MNM2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LW12-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW12/entry", "sequence": { "sequence": "MQEKSTLVRFWSGLLMLLGFLCPRSSPCGISTHIEIGHRALEFLHLQDGSINYKELLLRHQDAYQAGSVFPDSFYPSICERGQFHDVSESTHWTPFLNASVHYIRKNYPLPWDEDTEKLVAFLFGITSHMVADVNWHSLGIEQGFLRTMAAIDFHNSYPEAHPAGDFGGDVLSQFEFKFNYLSRHWYVPAEDLLGIYKELYGRVVITKKAIVDCSYLQFLEMYAEMLAISKLYPTYSVKSPFLVEQFQEYFLGGLEDMAFWSTNIYHLTSYMLKNGTSNCNLPENPLFITCGGQQNNTHGSKVQKNGFHKNVTAALTKNIGKHINYTKRGVFFSVDSWTMDSLSFMYKSLERSIREMFIGSSQPLTHVSSPSASYYLSFPYTRLGWAMTSADLNQDGYGDLVVGAPGYSHPGRIHVGRVYLIYGNDLGLPPVDLDLDKEAHEILEGFQPSGRFGSAVAVLDFNVDGVPDLAVGAPSVGSEKLTYTGAVYVYFGSKQGQLSSSPNVTISCQDTYCNLGWTLLAADVNGDSEPDLVIGSPFAPGGGKQKGIVAAFYSGSSYSSQEKLNVEAANWMVKGEEDFAWLGYSLHGVNVNNRTLLLAGSPTWKDTSSQGHLFRTRDEKQSPGRVYGYFPPICQSWFTISGDKAMGKLGTSLSSGHVMVNGTRTQVLLVGAPTQDEIIVAAPLRITDATAGLMGEEDGRVYVFNGKQITVGDVTGKCKSWVTPCPEEKAQYVLISPEAGSRFGSSVITVRSKEKNQVIIAAGRSSLGARLSGVLHIYRLGQD", "length": 784, "header": "tr|A0A3Q1LW12-1|F1MNM2_BOVIN Computationally mapped isoform of Phosphatidylinositol-glycan-specific phospholipase D OS=Bos taurus OX=9913 GN=GPLD1 PE=3 SV=2 CANONICAL=F1MNM2-1" }, "locus": { "chromosome": "23", "start_pos": 33268575, "end_pos": 33217169, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083056.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083056.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059557.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059557.2" } ] } }, { "isoform_ac": "A0A3Q1MEX6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEX6/entry", "sequence": { "sequence": "MSAFRFWSGLLMLLGFLCPRSSPCGISTHIEIGHRALEFLHLQDGSINYKELLLRHQDAYQAGSVFPDSFYPSICERGQFHDVSESTHWTPFLNASVHYIRKNYPLPWDEDTEKLVAFLFGITSHMVADVNWHSLGIEQGFLRTMAAVSTYKYFSHIIGGDVLSQFEFKFNYLSRHWYVPAEDLLGIYKELYGRVVITKKAIVDCSYLQFLEMYAEMLAISKLYPTYSVKSPFLVEQFQEYFLGGLEDMAFWSTNIYHLTSYMLKNGTSNCNLPENPLFITCGGQQNNTHGSKVQKNGFHKNVTAALTKNIGKHINYTKRGVFFSVDSWTMDSLSFMYKSLERSIREMFIGSSQPLTHVSSPSASYYLSFPYTRLGWAMTSADLNQDGYGDLVVGAPGYSHPGRIHVGRVYLIYGNDLGLPPVDLDLDKEAHEILEGFQPSGRFGSAVAVLDFNVDGVPDLAVGAPSVGSEKLTYTGAVYVYFGSKQGQLSSSPNVTISCQDTYCNLGWTLLAADVNGDSEPDLVIGSPFAPGGGKQKGIVAAFYSGSSYSSQEKLNVEAANWMVKGEEDFAWLGYSLHGVNVNNRTLLLAGSPTWKDTSSQGHLFRTRDEKQSPGRVYGYFPPICQSWFTISGDKAMGKLGTSLSSGHVMVNGTRTQVLLVGAPTQDVVSKVSFLTMTLHQGGSTRMYELTPDSQPSLLSTFSGNRRFSRFGGVLHLSDLDNDGSDEIIVAAPLRITDATAGLMGEEDGRVYVFNGKQITVGDVTGKCKSWVTPCPEEKVSAGSRFGSSVITVRSKEKNQVIIAAGRSSLGARLSGVLHIYRLGQD", "length": 827, "header": "tr|A0A3Q1MEX6-1|F1MNM2_BOVIN Computationally mapped isoform of Phosphatidylinositol-glycan-specific phospholipase D OS=Bos taurus OX=9913 GN=GPLD1 PE=3 SV=1 CANONICAL=F1MNM2-1" }, "locus": { "chromosome": "23", "start_pos": 33268575, "end_pos": 33217647, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000078409.3", "url": "https://www.ensembl.org/id/ENSBTAT00000078409.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067452.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067452.1" } ] } }, { "isoform_ac": "A0AAA9TA69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA69/entry", "sequence": { "sequence": "MQEKSTLVRFWSGLLMLLGFLCPRSSPCGISTHIEIGHRALEFLHLQDGSINYKEDTEKLVAFLFGITSHMVADVNWHSLGIEQGFLRTMAAIDFHNSYPEAHPAGDFGGDVLSQFEFKFNYLSRHWYVPAEDLLGIYKELYGRVVITKKAIVDCSYLQFLEMYAEMLAISKLYPTYSVKSPFLVEQFQEYFLGGLEDMAFWSTNIYHLTSYMLKNGTSNCNLPENPLFITCGGQQNNTHGSKVQKNGFHKNVTAALTKNIGKHINYTKRGVFFSVDSWTMDSLSFMYKSLERSIREMFIGSSQPLTHVSSPSASYYLSFPYTRLGWAMTSADLNQDGYGDLVVGAPGYSHPGRIHVGRVYLIYGNDLGLPPVDLDLDKEAHEILEGFQPSGRFGSAVAVLDFNVDGVPDLAVGAPSVGSEKLTYTGAVYVYFGSKQGQLSSSPNVTISCQDTYCNLGWTLLAADVNGDSEPDLVIGSPFAPGGGKQKGIVAAFYSGSSYSSQEKLNVEAANWMVKGEEDFAWLGYSLHGVNVNNRTLLLAGSPTWKDTSSQGHLFRTRDEKQSPGRVYGYFPPICQSWFTISGDKAMGKLGTSLSSGHVMVNGTRTQVLLVGAPTQDVVSKVSFLTMTLHQGGSTRMYELTPDSQPSLLSTFSGNRRFSRFGGVLHLSDLDNDGSDEIIVAAPLRITDATAGLMGEEDGRVYVFNGKQITVGDVTGKCKSWVTPCPEEKAQYVLISPEAGSRFGSSVITVRSKEKNQVIIAAGRSSLGARLSGVLHIYRLGQD", "length": 784, "header": "tr|A0AAA9TA69-1|F1MNM2_BOVIN Computationally mapped isoform of Phosphatidylinositol-glycan-specific phospholipase D OS=Bos taurus OX=9913 GN=GPLD1 PE=3 SV=1 CANONICAL=F1MNM2-1" }, "locus": { "chromosome": "23", "start_pos": 33268575, "end_pos": 33217169, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132070.2", "url": "https://www.ensembl.org/id/ENSBTAT00000132070.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095606.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095606.1" } ] } }, { "isoform_ac": "F1MNM2-1", "url": "https://www.uniprot.org/uniprotkb/F1MNM2/entry", "sequence": { "sequence": "MITCPIALVAAEAEEAGQPDICAEKMQEKSTLVRFWSGLLMLLGFLCPRSSPCGISTHIEIGHRALEFLHLQDGSINYKELLLRHQDAYQAGSVFPDSFYPSICERGQFHDVSESTHWTPFLNASVHYIRKNYPLPWDEDTEKLVAFLFGITSHMVADVNWHSLGIEQGFLRTMAAIDFHNSYPEAHPAGDFGGDVLSQFEFKFNYLSRHWYVPAEDLLGIYKELYGRVVITKKAIVDCSYLQFLEMYAEMLAISKLYPTYSVKSPFLVEQFQEYFLGGLEDMAFWSTNIYHLTSYMLKNGTSNCNLPENPLFITCGGQQNNTHGSKVQKNGFHKNVTAALTKNIGKHINYTKRGVFFSVDSWTMDSLSFMYKSLERSIREMFIGSSQPLTHVSSPSASYYLSFPYTRLGWAMTSADLNQDGYGDLVVGAPGYSHPGRIHVGRVYLIYGNDLGLPPVDLDLDKEAHEILEGFQPSGRFGSAVAVLDFNVDGVPDLAVGAPSVGSEKLTYTGAVYVYFGSKQGQLSSSPNVTISCQDTYCNLGWTLLAADVNGDSEPDLVIGSPFAPGGGKQKGIVAAFYSGSSYSSQEKLNVEAANWMVKGEEDFAWLGYSLHGVNVNNRTLLLAGSPTWKDTSSQGHLFRTRDEKQSPGRVYGYFPPICQSWFTISGDKAMGKLGTSLSSGHVMVNGTRTQVLLVGAPTQDVVSKVSFLTMTLHQGGSTRMYELTPDSQPSLLSTFSGNRRFSRFGGVLHLSDLDNDGSDEIIVAAPLRITDATAGLMGEEDGRVYVFNGKQITVGDVTGKCKSWVTPCPEEKAQYVLISPEAGSRFGSSVITVRSKEKNQVIIAAGRSSLGARLSGVLHIYRLGQD", "length": 868, "header": "tr|F1MNM2-1|F1MNM2_BOVIN Isoform 1 of Phosphatidylinositol-glycan-specific phospholipase D OS=Bos taurus OX=9913 GN=GPLD1 PE=3 SV=3 CANONICAL=F1MNM2-1" }, "locus": { "chromosome": "23", "start_pos": 33268575, "end_pos": 33210257, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006557.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006557.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006557.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006557.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-163125", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-163125", "resource": "Reactome", "description": "Post-translational modification: synthesis of GPI-anchored proteins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "glycosylphosphatidylinositol phospholipase D activity", "id": "GO:0004621", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004621", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "complement receptor mediated signaling pathway", "id": "GO:0002430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002430", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "cellular response to triglyceride", "id": "GO:0071401", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071401", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "regulation of cellular response to insulin stimulus", "id": "GO:1900076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900076", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "cellular response to cholesterol", "id": "GO:0071397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071397", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell migration", "id": "GO:0010595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010595", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "cellular response to xenobiotic stimulus", "id": "GO:0071466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071466", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "insulin receptor signaling pathway", "id": "GO:0008286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008286", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "response to glucose", "id": "GO:0009749", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009749", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "protein secretion", "id": "GO:0009306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009306", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "cellular response to pH", "id": "GO:0071467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071467", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" }, { "name": "cell migration involved in sprouting angiogenesis", "id": "GO:0002042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002042", "evidence": [ { "database": "UniProtKB", "id": "F1MNM2", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 300, "end_pos": 302, "annotation": "n_glycosylation_sequon" }, { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" }, { "start_pos": 336, "end_pos": 338, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 529, "end_pos": 531, "annotation": "n_glycosylation_sequon" }, { "start_pos": 619, "end_pos": 621, "annotation": "n_glycosylation_sequon" }, { "start_pos": 687, "end_pos": 689, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "86263", "name": "", "equation": "[protein]-C-terminal carboxyl phosphoethanolamide-(1-radyl-2-octadecanoyl)-GPI(deacylinositol-H7) + H2O = [protein]-C-terminal carboxyl phosphoethanolamide-glycosylinositol (deacylinositol-H7) + 1-radyl-2-octadecanoyl-sn-glycero-3-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P80109-1", "F1MNM2-1" ], "evidence": [ { "id": "86263", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/86263" } ] }, { "id": "R-BTA-8940388", "name": "GPLD1 hydrolyses GPI-anchors from proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-2197633" ], "enzyme_list": [ "F1MLP3-1", "A0A3Q1LSG5-1", "P09487-1", "E1B735-1", "A0AAA9S718-1", "F1MNM2-1", "F1MPH8-1", "A0A140T891-1", "A0A3Q1MCB1-1", "E1BJE3-1" ], "evidence": [ { "id": "R-BTA-8940388", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8940388" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2197633", "participant_name": "PI [extracellular region]", "crossref": [ { "id": "57880", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A140T891", "gene_name": "VNN1", "activity": [ { "ec_number": "3.5.1.92", "activity": "(R)-pantetheine + H2O = cysteamine + (R)-pantothenate.", "evidence": [ { "id": "A0A140T891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T891" } ] }, { "ec_number": "3.5.1.92", "activity": "", "evidence": [ { "id": "A0A140T891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140T891" } ] } ] }, { "uniprot_ac": "A0A3Q1LSG5", "gene_name": "LOC100125266", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1LSG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG5" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1LSG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSG5" } ] } ] }, { "uniprot_ac": "A0A3Q1MCB1", "gene_name": "", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1MCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCB1" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "A0A3Q1MCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCB1" } ] } ] }, { "uniprot_ac": "A0AAA9S718", "gene_name": "SMCO3", "activity": [ { "ec_number": "2.4.2.31", "activity": "L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+).", "evidence": [ { "id": "A0AAA9S718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718" } ] }, { "ec_number": "2.4.2.31", "activity": "", "evidence": [ { "id": "A0AAA9S718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S718" } ] } ] }, { "uniprot_ac": "E1B735", "gene_name": "XPNPEP2", "activity": [ { "ec_number": "3.4.11.9", "activity": "Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.", "evidence": [ { "id": "E1B735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B735" } ] }, { "ec_number": "3.4.11.9", "activity": "", "evidence": [ { "id": "E1B735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B735" } ] } ] }, { "uniprot_ac": "E1BJE3", "gene_name": "LOC516378", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "E1BJE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJE3" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "E1BJE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJE3" } ] } ] }, { "uniprot_ac": "F1MLP3", "gene_name": "BST1", "activity": [ { "ec_number": "3.2.2.6", "activity": "NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+).", "evidence": [ { "id": "F1MLP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLP3" } ] }, { "ec_number": "3.2.2.6", "activity": "", "evidence": [ { "id": "F1MLP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLP3" } ] } ] }, { "uniprot_ac": "F1MNM2", "gene_name": "GPLD1", "activity": [ { "ec_number": "3.1.4.50", "activity": "[protein]-C-terminal carboxyl phosphoethanolamide-(1-radyl-2-octadecanoyl)-GPI(deacylinositol-H7) + H2O = [protein]-C-terminal carboxyl phosphoethanolamide-glycosylinositol (deacylinositol-H7) + 1-radyl-2-octadecanoyl-sn-glycero-3-phosphate + H(+).", "evidence": [ { "id": "F1MNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ] }, { "ec_number": "3.1.4.50", "activity": "", "evidence": [ { "id": "F1MNM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNM2" } ] } ] }, { "uniprot_ac": "F1MPH8", "gene_name": "LOC528262", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "F1MPH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPH8" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "F1MPH8", "database": "UniProtKB", "url": 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"UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMX8-1", "url": "https://www.uniprot.org/uniprotkb/F1MMX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QT14", "url": "https://www.uniprot.org/uniprotkb/F6QT14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QT14-1", "url": "https://www.uniprot.org/uniprotkb/F6QT14-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQREEKQLEASLDALLSQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPAGSSGPSQPGQPGAGTVLAGASGLQQVQMAGAPNQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQRPRSRTCPDLRLLHVCGELMDTRSWTAQLCLKSCAYSVLPEMVTASVSLEAHCLHRPGFPDSSLAISPGCR", "length": 338, "header": "tr|F1MMX8-1|F1MMX8_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 8 OS=Bos taurus OX=9913 GN=MED8 PE=3 SV=4 CANONICAL=F1MMX8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LN70-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN70/entry", "sequence": { "sequence": "MLLRCPKHNKSQREEKQLEASLDALLSQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPAGSSGPSQPGQPGAGTVLAGASGLQQVQMAGAPNQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR", "length": 278, "header": "tr|A0A3Q1LN70-1|F1MMX8_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 8 OS=Bos taurus OX=9913 GN=MED8 PE=3 SV=2 CANONICAL=F1MMX8-1" }, "locus": { "chromosome": "3", "start_pos": 102634557, "end_pos": 102630607, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070113.3", "url": "https://www.ensembl.org/id/ENSBTAT00000070113.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058228.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058228.2" } ] } }, { "isoform_ac": "A0A3Q1MD86-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD86/entry", "sequence": { "sequence": "MQREEKQLEASLDALLSQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPAGSSGPSQPGQPGAGTVLAGASGLQQVQMAGAPNQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQRSPPPSTLGISTKNSSSLWWPHSSWALESSACCSGSVSYV", "length": 307, "header": "tr|A0A3Q1MD86-1|F1MMX8_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 8 OS=Bos taurus OX=9913 GN=MED8 PE=3 SV=1 CANONICAL=F1MMX8-1" }, "locus": { "chromosome": "3", "start_pos": 102646638, "end_pos": 102629387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071263.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071263.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068878.1", "url": "https://www.ensembl.org/id/ENSBTAP00000068878.1" } ] } }, { "isoform_ac": "A0A3Q1MDC5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDC5/entry", "sequence": { "sequence": "MSKSTKTCPGSVSDKGSCSRQEAEPLARMEAIVNLYQEMMKHADPRVQGYPLMESPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMVVYNFSLVALSLYIVYEFLMSGWLSSYTWRCDPVDFSNNPEALRMVRVAWLFLFSKFIELIDTLIFVLRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVVMYLYYGLSALGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFLPSCNYQYPVIIHLIWMYGTIFFVLFSNFWYQSYTKGKRLPRVSQQNGVPGTTKVKAN", "length": 307, "header": "tr|A0A3Q1MDC5-1|A0A3Q1MDC5_BOVIN Computationally mapped isoform of Elongation of very long chain fatty acids protein 1 OS=Bos taurus OX=9913 GN=ELOVL1 PE=3 SV=1 CANONICAL=F1MMX8-1" }, "locus": { "chromosome": "3", "start_pos": 102654461, "end_pos": 102651186, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086981.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086981.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072145.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072145.2" } ] } }, { "isoform_ac": "A0A3Q1MID5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MID5/entry", "sequence": { "sequence": "MQREEKQLEASLDALLSQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPAGSSGPSQPGQPGAGTVLAGASGLQQVQMAGAPNQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQRSPPPSTLGISTKNSSSLWWPHSSWALESSACCSGL", "length": 303, "header": "tr|A0A3Q1MID5-1|F1MMX8_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 8 OS=Bos taurus OX=9913 GN=MED8 PE=3 SV=1 CANONICAL=F1MMX8-1" }, "locus": { "chromosome": "3", "start_pos": 102647230, "end_pos": 102629387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077789.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077789.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071026.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071026.1" } ] } }, { "isoform_ac": "A0A3Q1MIU0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIU0/entry", "sequence": { "sequence": "MTLEPLARMEAIVNLYQEMMKHADPRVQGYPLMESPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMVVYNFSLVALSLYIVYEFLMSGWLSSYTWRCDPVDFSNNPEALRMVRVAWLFLFSKFIELIDTLIFVLRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVVMYLYYGLSALGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFLPSCNYQYPVIIHLIWMYGTIFFVLFSNFWYQSYTKGKRLPRVSQQNGVPGTTKVKAN", "length": 287, "header": "tr|A0A3Q1MIU0-1|F1MMX8_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 8 OS=Bos taurus OX=9913 GN=MED8 PE=3 SV=2 CANONICAL=F1MMX8-1" }, "locus": { "chromosome": "3", "start_pos": 102654461, "end_pos": 102650938, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071105.3", "url": "https://www.ensembl.org/id/ENSBTAT00000071105.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070656.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070656.2" } ] } }, { "isoform_ac": "A0AAA9TK69-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK69/entry", "sequence": { "sequence": "MKVKSESEVAQLCPTLGNPMDCSLPGSSVHGILQREEKQLEASLDALLSQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPAGSSGPSQPGQPGAGTVLAGASGLQQVQMAGAPNQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR", "length": 300, "header": "tr|A0AAA9TK69-1|F1MMX8_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 8 OS=Bos taurus OX=9913 GN=MED8 PE=3 SV=1 CANONICAL=F1MMX8-1" }, "locus": { "chromosome": "3", "start_pos": 102634557, "end_pos": 102626742, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105409.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105409.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098767.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098767.1" } ] } }, { "isoform_ac": "A0AAA9TTB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTB3/entry", "sequence": { "sequence": "MEAIVNLYQEMMKHADPRVQGYPLMESPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMVVYNFSLVALSLYIVYEMVRVAWLFLFSKFIELIDTLIFVLRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVVMYLYYGLSALGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFLPSCNYQYPVIIHLIWMYGTIFFVLFSNFWYQSYTKGKRLPRVSQQNGVPGTTKVKAN", "length": 252, "header": "tr|A0AAA9TTB3-1|F1MMX8_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 8 OS=Bos taurus OX=9913 GN=MED8 PE=3 SV=1 CANONICAL=F1MMX8-1" }, "locus": { "chromosome": "3", "start_pos": 102654461, "end_pos": 102652813, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113540.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113540.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100584.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100584.1" } ] } }, { "isoform_ac": "A0ABI0P1T9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1T9/entry", "sequence": { "sequence": "MQREEKQLEASLDALLSQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPAGSSGPSQPGQPGAGTVLAGASGLQQVQMAGAPNQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQRKSAQQMRKWQAGWPWGLLSSLAPSQPSTTARLAPTGGLCEFVYVTALI", "length": 316, "header": "tr|A0ABI0P1T9-1|A0ABI0P1T9_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 8 OS=Bos taurus OX=9913 GN=ELOVL1 PE=3 SV=1 CANONICAL=F1MMX8-1" }, "locus": { "chromosome": "3", "start_pos": 102651038, "end_pos": 102629387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145470.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145470.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104691.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104691.1" } ] } }, { "isoform_ac": "F1MMX8-1", "url": "https://www.uniprot.org/uniprotkb/F1MMX8/entry", "sequence": { "sequence": "MQREEKQLEASLDALLSQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPAGSSGPSQPGQPGAGTVLAGASGLQQVQMAGAPNQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQRPRSRTCPDLRLLHVCGELMDTRSWTAQLCLKSCAYSVLPEMVTASVSLEAHCLHRPGFPDSSLAISPGCR", "length": 338, "header": "tr|F1MMX8-1|F1MMX8_BOVIN Isoform 1 of Mediator of RNA polymerase II transcription subunit 8 OS=Bos taurus OX=9913 GN=MED8 PE=3 SV=4 CANONICAL=F1MMX8-1" }, "locus": { "chromosome": "3", "start_pos": 102635116, "end_pos": 102629387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022477.8", "url": "https://www.ensembl.org/id/ENSBTAT00000022477.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022477.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022477.7" } ] } }, { "isoform_ac": "F6QT14-1", "url": "https://www.uniprot.org/uniprotkb/F6QT14/entry", "sequence": { "sequence": "MRKWQAGWPWGLLSSLAPSQPSTTARLAPTEPLARMEAIVNLYQEMMKHADPRVQGYPLMESPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMVVYNFSLVALSLYIVYEFLMSGWLSSYTWRCDPVDFSNNPEALRMVRVAWLFLFSKFIELIDTLIFVLRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVVMYLYYGLSALGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFLPSCNYQYPVIIHLIWMYGTIFFVLFSNFWYQSYTKGKRLPRVSQQNGVPGTTKVKAN", "length": 314, "header": "tr|F6QT14-1|F1MMX8_BOVIN Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 8 OS=Bos taurus OX=9913 GN=MED8 PE=3 SV=1 CANONICAL=F1MMX8-1" }, "locus": { "chromosome": "3", "start_pos": 102654461, "end_pos": 102650203, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012940.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012940.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012940.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012940.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-212436", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212436", "resource": "Reactome", "description": "Generic Transcription Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AU03-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 8", "gene_name": "Med8", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQREEKQLEASLDALLNQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPSGSSGPGQPGQPGAGTILAGASGLQQVQMAGAPNQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQRSDEASTAFTWEMGKSAHLLPSSGLKMSRDQQVSALPRDLLRSDPTLSGSSTDTSLSSSLEGNCASLMFVGFTCPHSNYSPSLTSSISPNMWLR", "length": 361 }, "evidence": [ { "id": "F1MMX8", "url": "https://omabrowser.org/oma/group/F1MMX8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A9J7JUH6-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 8", "gene_name": "Med8", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MACMYYRGTHEREEKQLEASLDALLNQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPSGSSGPGQPGQPGAGTILAGASGLQQVQMAGAPNQQQTMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR", "length": 277 }, "evidence": [ { "id": "F1MMX8", "url": "https://omabrowser.org/oma/group/F1MMX8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A1ZBT5-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 8", "gene_name": "MED8", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQRDEKLFELTLDTVLQRLNDLKLAVLSMIQKLELEYETINWPTFLDNFAIISSHLTGLTKILAKEQCPPLRNRTVLPLLVSMDRDDTLINITEGRVPVFSHDIVPDYLRTRPDPITEQKMLQNEQKAANLTNDAAMKQVTQYNKVVSHVLDMVSKAREEWEIESSSRTGIQQTSSMADTQLLVAAVGMGKGLKLTNYGPGPGMMVPPSIRAPSPMGGPAMSPGNVQQQLGKAPSAVKTNIKSANQVHPFSR", "length": 252 }, "evidence": [ { "id": "F1MMX8", "url": "https://omabrowser.org/oma/group/F1MMX8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "F1NG55-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 8", "gene_name": "MED8", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQREEKQLELTLEALISQVADLKNSLVSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLLRNQVIIPLVLSPDRDEEIMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLITDAARISPDGAQKQIQSLNKMCSNLLEKISKEERESESGGLRQNKQTFNPTDTNALVAAVAFGKGLSNRRPPGSGGSVQSGQPGAGAIIAGASGMQQVPMSSAPAQQQPMLAGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR", "length": 268 }, "evidence": [ { "id": "F1MMX8", "url": "https://omabrowser.org/oma/group/F1MMX8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S313-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 8", "gene_name": "MED8", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEREEKQLEASLDALLSQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESEGGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPSGSSGPGQPGQPGAGTVLAGASGLQQVQMAGAPSQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR", "length": 268 }, "evidence": [ { "id": "F1MMX8", "url": "https://omabrowser.org/oma/group/F1MMX8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q96G25-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 8", "gene_name": "MED8", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPTDTNALVAAVAFGKGLSNWRPSGSSGPGQAGQPGAGTILAGTSGLQQVQMAGAPSQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR", "length": 268 }, "evidence": [ { "id": "F1MMX8", "url": "https://omabrowser.org/oma/group/F1MMX8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D7W5-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 8", "gene_name": "Med8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQREEKQLEASLDALLNQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPGDTNALVAAVAFGKGLSNWRPSGSSGPGQPGQPGAGTILAGASGLPQVQMPGAPNQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR", "length": 268 }, "evidence": [ { "id": "F1MMX8", "url": "https://omabrowser.org/oma/group/F1MMX8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" }, { "name": "long-chain fatty-acyl-CoA biosynthetic process", "id": "GO:0035338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035338", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" }, { "name": "unsaturated fatty acid biosynthetic process", "id": "GO:0006636", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006636", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" }, { "name": "fatty acid elongation, monounsaturated fatty acid", "id": "GO:0034625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034625", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" }, { "name": "fatty acid elongation, saturated fatty acid", "id": "GO:0019367", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019367", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" }, { "name": "very long-chain fatty acid biosynthetic process", "id": "GO:0042761", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042761", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" }, { "name": "fatty acid biosynthetic process", "id": "GO:0006633", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006633", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" }, { "name": "mediator complex", "id": "GO:0016592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" }, { "name": "core mediator complex", "id": "GO:0070847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070847", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" }, { "name": "fatty acid elongase activity", "id": "GO:0009922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009922", "evidence": [ { "database": "UniProtKB", "id": "F1MMX8", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "32727", "name": "", "equation": "a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BBK7-1", "F1MMX8-1", "A0JNC4-1", "Q2KJD9-1", "A0AAF6DMC9-1", "E1BBR7-1" ], "evidence": [ { "id": "32727", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/32727" } ] }, { "id": "R-BTA-212352", "name": "Formation of ARC coactivator complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MMX8-1", "F1MPI8-1" ], "evidence": [ { "id": "R-BTA-212352", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-212352" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAF6DMC9", "gene_name": "ELOVL6", "activity": [ { "ec_number": "2.3.1.199", "activity": "a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA.", "evidence": [ { "id": "A0AAF6DMC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC9" } ] }, { "ec_number": "2.3.1.199", "activity": "", "evidence": [ { "id": "A0AAF6DMC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMC9" } ] } ] }, { "uniprot_ac": "A0JNC4", "gene_name": "ELOVL7", "activity": [ { "ec_number": "2.3.1.199", "activity": "a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA.", "evidence": [ { "id": "A0JNC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNC4" } ] }, { "ec_number": "2.3.1.199", "activity": "", "evidence": [ { "id": "A0JNC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JNC4" } ] } ] }, { "uniprot_ac": "E1BBK7", "gene_name": "", "activity": [ { "ec_number": "2.3.1.199", "activity": "a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA.", "evidence": [ { "id": "E1BBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBK7" } ] }, { "ec_number": "2.3.1.199", "activity": "", "evidence": [ { "id": "E1BBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBK7" } ] } ] }, { "uniprot_ac": "E1BBR7", "gene_name": "ELOVL3", "activity": [ { "ec_number": "2.3.1.199", "activity": "a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA.", "evidence": [ { "id": "E1BBR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBR7" } ] }, { "ec_number": "2.3.1.199", "activity": "", "evidence": [ { "id": "E1BBR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBR7" } ] } ] }, { "uniprot_ac": "F1MMX8", "gene_name": "MED8", "activity": [ { "ec_number": "2.3.1.199", "activity": "a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA.", "evidence": [ { "id": "F1MMX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ] }, { "ec_number": "2.3.1.199", "activity": "", "evidence": [ { "id": "F1MMX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMX8" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "Q2KJD9", "gene_name": "ELOVL5", "activity": [ { "ec_number": "2.3.1.199", "activity": "a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA.", "evidence": [ { "id": "Q2KJD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJD9" } ] }, { "ec_number": "2.3.1.199", "activity": "", "evidence": [ { "id": "Q2KJD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJD9" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MMX8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 338, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MMX8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MMX8" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.1.199", "ec_name": "a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA.", "evidence": [ { "id": "2.3.1.199", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199" }, { "id": "2.3.1.199", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.1.199" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MLJ5-1", "uniprot_ac": "F1MLJ5", "uniprot_id": "F1MLJ5_BOVIN", "mass": { "chemical_mass": 101058.0, "monoisotopic_mass": 101058.0 }, "refseq": {}, "gene_names": [ { "name": "OSBPL3", "type": "recommended", "evidence": [ { "id": "F1MLJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5" } ] } ], "protein_names": [ { "name": "Oxysterol-binding protein", "type": "recommended", "evidence": [ { "id": "F1MLJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Lipid transfer protein that mediates the non-vesicular transport of phosphoinositide 4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), or PI(4)P) at the plasma membrane (PM)/ endoplasmic reticulum (ER) contact sites. Extracts PI4P from the PM, in exchange for phosphatidylcholine. Can bind to the ER membrane protein VAPA and recruit VAPA to PM sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M385", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M385#function" }, { "database": "UniProtKB", "id": "ARBA00094149", "url": "https://www.uniprot.org/uniprotkb/ARBA00094149#function" }, { "database": "UniProtKB", "id": "A0A3Q1MX43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MX43#function" }, { "database": "UniProtKB", "id": "F1MLJ5", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MLJ5", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OSBPL3", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5", "locus": { "chromosome": "4", "start_pos": 71041083, "end_pos": 70942687, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019342", "url": "https://www.ensembl.org/id/ENSBTAG00000019342" } ] } } ], "crossref": [ { "id": "F1MLJ5", "url": "https://alphafold.ebi.ac.uk/entry/F1MLJ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019342", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019342", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13287", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13287", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000648", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000648", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037239", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037239", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M385", "url": "https://www.orthodb.org/?gene=A0A3Q1M385", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MX43", "url": "https://www.orthodb.org/?gene=A0A3Q1MX43", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MLJ5", "url": "https://www.orthodb.org/?gene=F1MLJ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10972", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10972", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10972:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10972:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01237", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01237", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15409", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15409", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-192105", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-192105", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "85491", "url": "https://www.rhea-db.org/rhea/85491", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M385", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M385", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M385-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M385-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MX43", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MX43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MX43-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MX43-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLJ5", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLJ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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OX=9913 GN=OSBPL3 PE=3 SV=4 CANONICAL=F1MLJ5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M385-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M385/entry", "sequence": { "sequence": 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GN=OSBPL3 PE=3 SV=2 CANONICAL=F1MLJ5-1" }, "locus": { "chromosome": "4", "start_pos": 71040823, "end_pos": 70942840, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079125.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079125.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062608.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062608.2" } ] } }, { "isoform_ac": "A0A3Q1MX43-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MX43/entry", "sequence": { "sequence": "RMSDEKSLAVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQEPPIQKGFLLKKRKWPLKGWHKRFFYLDRGILKYAKNQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKSEDVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFPGSTVPDSGPGVMDTISSRKRSSISKQNSFQTGSNLSFSCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQNMDILHRTYSAPAINAIQGGAFESPKKEKRSHRRWRSRALGKDAKGTLQVPKPFSGPIRLHSSNPNLSTLDFGEEKNYSDGSETSSEFSKMQEDLCHIAHKVYFTLRSAFNTISTEREKLKQLMEQDVSASPSAQVLGLKHALSSENSRDDSRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISEDDSYVSDISDNFSLDNLSNDLDNERQTLGPVIDSGGEARSKRRTCLPAPCPKSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQLPNALERMVYVAAFAVSAYASSYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHAESANFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLNDDSCHCKVNFIKAKYWSTNAHEIEGTVFDQSGKAVHRLFGKWHESIYCGGSSSSACIWRANPMPKGYEQYYGFTQFALELNEMDPLLKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLEENKVEHQPRFFRKSIDDSWVSNGTYLELRKDFGFSKLDHPVLW", "length": 851, "header": "tr|A0A3Q1MX43-1|F1MLJ5_BOVIN Computationally mapped isoform of Oxysterol-binding protein OS=Bos taurus OX=9913 GN=OSBPL3 PE=3 SV=2 CANONICAL=F1MLJ5-1" }, "locus": { "chromosome": "4", "start_pos": 71040823, "end_pos": 70942840, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085579.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085579.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060232.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060232.2" } ] } }, { "isoform_ac": "F1MLJ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5/entry", "sequence": { "sequence": "RMSDEKSLAVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQEPPIQKGFLLKKRKWPLKGWHKRFFYLDRGILKYAKNQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKSEDVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFPGSTVPDSGPGVMDTISSRKRSSISKQNSFQTGSNLSFSCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQNMDILHRTYSAPAINAIQGGAFESPKKEKRSHRRWRSRALGKDAKGTLQVPKPFSGPIRLHSSNPNLSTLDFGEEKNYSDGSETSSEFSKMQEDLCHIAHKVYFTLRSAFNTISTEREKLKQLMEQDVSASPSAQVLGLKHALSSALAQNTDLKERLCRIHAESLLLDLPAAAKSGDGLAEENSRDDSRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISEDDSYVSDISDNFSLDNLSNDLDNERQTLGPVIDSGGEARSKRRTCLPAPCPKSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQLPNALERMVYVAAFAVSAYASSYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHAESANFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLNDDSCHCKVNFIKAKYWSTNAHEIEGTVFDQSGKAVHRLFGKWHESIYCGGSSSSACIWRANPMPKGYEQYYGFTQFALELNEMDPLLKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLEENKVEHQPRFFRKSIDDSWVSNGTYLELRKDFGFSKLDHPVLW", "length": 887, "header": "tr|F1MLJ5-1|F1MLJ5_BOVIN Isoform 1 of Oxysterol-binding protein OS=Bos taurus OX=9913 GN=OSBPL3 PE=3 SV=4 CANONICAL=F1MLJ5-1" }, "locus": { "chromosome": "4", "start_pos": 71040823, "end_pos": 70942840, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025767.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025767.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025767.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025767.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-192105", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-192105", "resource": "Reactome", "description": "Synthesis of bile acids and bile salts" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ5", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ5", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ5", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5" } ], "pmid": "" }, { "name": "perinuclear endoplasmic reticulum", "id": "GO:0097038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097038", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ5", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ5", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5" } ], "pmid": "" }, { "name": "filopodium tip", "id": "GO:0032433", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032433", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ5", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ5", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "bile acid biosynthetic process", "id": "GO:0006699", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006699", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ5", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ5", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5" } ], "pmid": "" }, { "name": "sterol transfer activity", "id": "GO:0120015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120015", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ5", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5" } ], "pmid": "" }, { "name": "cholesterol binding", "id": "GO:0015485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015485", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ5", "url": "https://www.uniprot.org/uniprotkb/F1MLJ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 307, "end_pos": 309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 318, "end_pos": 320, "annotation": "n_glycosylation_sequon" }, { "start_pos": 438, "end_pos": 440, "annotation": "n_glycosylation_sequon" }, { "start_pos": 46, "end_pos": 48, "annotation": "n_glycosylation_sequon" }, { "start_pos": 481, "end_pos": 483, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 525, "end_pos": 527, "annotation": "n_glycosylation_sequon" }, { "start_pos": 866, "end_pos": 868, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "85491", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "85491", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/85491" } ] } ], "reaction_participants": [], "reaction_enzymes": [], 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} ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJQ5-1", "uniprot_ac": "F1MJQ5", "uniprot_id": "F1MJQ5_BOVIN", "mass": { "chemical_mass": 49311.0, "monoisotopic_mass": 49311.0 }, "refseq": {}, "gene_names": [ { "name": "NDUFAF7", "type": "recommended", "evidence": [ { "id": "F1MJQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ] } ], "protein_names": [ { "name": "Protein arginine methyltransferase NDUFAF7", "type": "recommended", "evidence": [ { "id": "F1MJQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5/entry#names_and_taxonomy" } ] }, { "name": "2.1.1.320", "type": "synonym", "evidence": [ { "id": "F1MJQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TEU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEU9#function" }, { "database": "UniProtKB", "id": "RU364114", "url": "https://www.uniprot.org/uniprotkb/RU364114#function" }, { "database": "UniProtKB", "id": "F1MJQ5", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5#function" }, { "database": "UniProtKB", "id": "ARBA00054758", "url": "https://www.uniprot.org/uniprotkb/ARBA00054758#function" }, { "database": "UniProtKB", "id": "A0A3Q1N564", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N564#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJQ5", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NDUFAF7", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5", "locus": { "chromosome": "11", "start_pos": 19675873, "end_pos": 19659154, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001113", "url": "https://www.ensembl.org/id/ENSBTAG00000001113" } ] } } ], "crossref": [ { "id": "F1MJQ5", "url": "https://alphafold.ebi.ac.uk/entry/F1MJQ5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001113", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001113", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR003788", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003788", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YYHPQRN", "url": "https://omabrowser.org/oma/group/YYHPQRN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N564", "url": "https://www.orthodb.org/?gene=A0A3Q1N564", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MJQ5", "url": "https://www.orthodb.org/?gene=F1MJQ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12049", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12049", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12049:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12049:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02636", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02636", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "48108", "url": "https://www.rhea-db.org/rhea/48108", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1N564", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N564", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N564-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N564-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEU9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TEU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJQ5", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJQ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNFLAAAGVRRLCAMRAVLPCLWRGKYFSSGNEPAENNTVTPMLRHLIYKIKSTGPITVAEYMKEVLTNPAKGYYMNRDMLGEEGDFITSPEISQMFGELLGIWFISEWIAAGKNAAFQLVELGPGKGTLLGDILRVFSQLGSLLKNCDISLHLVEVSQKLSEIQALTLTEEKVPLERNAESPVYMKGVTKSGIPVSWYRDLQDVPKEYSFYLAHEFFDVLPVHKFQKTPHGWREVLVDIDPQVSDKLRFVLAPCATPAEAFIQNDETRDHVEVCPEAGVVIQELSQRISLTGGAALIADYGHDGTKTDTFRGFCGHRLHDVLTAPGTADLTADVDFSYLRRMSQGKVASLGPVEQQTFLRNMGIDVRLKILLDKTDDPSLRQQLLQGYNMLMNPMKMGERFNFLALVPHQRLHGRNHQTNARQSKPSPSPVAGFGELAWQ", "length": 441, "header": "tr|F1MJQ5-1|F1MJQ5_BOVIN Isoform 1 of Protein arginine methyltransferase NDUFAF7 OS=Bos taurus OX=9913 GN=NDUFAF7 PE=3 SV=2 CANONICAL=F1MJQ5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N564-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N564/entry", "sequence": { "sequence": "LRFLMSSVLPCLWRGKYFSSGNEPAENNTVTPMLRHLIYKIKSTGPITVAEYMKEVLTNPAKGYYMNRDMLGEEGDFITSPEISQMFGELLGIWFISEWIAAGKNAAFQLVELGPGKGTLLGDILRVFSQLGSLLKNCDISLHLVEVSQKLSEIQALTLTEEKVPLERNAESPVYMKGVTKSGIPVSWYRDLQDVPKEYSFYLAHEFFDVLPVHKFQKTPHGWREVLVDIDPQVSDKLRFVLAPCATPAEAFIQNDETRDHVEVCPEAGVVIQELSQRISLTGGAALIADYGHDGTKTDTFRGFCGHRLHDVLTAPGTADLTADVDFSYLRRMSQGKVASLGPVEQQTFLRNMGIDVRLKILLDKTDDPSLRQQLLQGYNMLMNPMKMGERFNFLALVPHQRLHGRNHQTNARQSKPSPSPVAGFGELAWQ", "length": 431, "header": "tr|A0A3Q1N564-1|F1MJQ5_BOVIN Computationally mapped isoform of Protein arginine methyltransferase NDUFAF7 OS=Bos taurus OX=9913 GN=NDUFAF7 PE=3 SV=1 CANONICAL=F1MJQ5-1" }, "locus": { "chromosome": "11", "start_pos": 19675614, "end_pos": 19659494, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068213.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068213.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065210.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065210.1" } ] } }, { "isoform_ac": "A0AAA9TEU9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TEU9/entry", "sequence": { "sequence": "MNFLAAAGVRRLCAMRAVLPCLWRGKYFSSGNEPAENNTVTPMLRHLIYKIKSTGPITVAEYMKEVLTNPAKLLGIWFISEWIAAGKNAAFQLVELGPGKGTLLGDILRVFSQLGSLLKNCDISLHLVEKTPHGWREVLVDIDPQVSDKLRFVLAPCATPAEAFIQNDETRDHVEVCPEAGVVIQELSQRISLTGGAALIADYGHDGTKTDTFRGFCGHRLHDVLTAPGTADLTADVDFSYLRRMSQGKVASLGPVEQQTFLRNMGIDVRLKILLDKTDDPSLRQQLLQGYNMLMNPMKMGERFNFLALVPHQRLHGRNHQTNARQSKPSPSPVAGFGELAWQ", "length": 343, "header": "tr|A0AAA9TEU9-1|F1MJQ5_BOVIN Computationally mapped isoform of Protein arginine methyltransferase NDUFAF7 OS=Bos taurus OX=9913 GN=NDUFAF7 PE=3 SV=1 CANONICAL=F1MJQ5-1" }, "locus": { "chromosome": "11", "start_pos": 19675614, "end_pos": 19659213, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112357.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112357.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095515.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095515.1" } ] } }, { "isoform_ac": "F1MJQ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5/entry", "sequence": { "sequence": "MNFLAAAGVRRLCAMRAVLPCLWRGKYFSSGNEPAENNTVTPMLRHLIYKIKSTGPITVAEYMKEVLTNPAKGYYMNRDMLGEEGDFITSPEISQMFGELLGIWFISEWIAAGKNAAFQLVELGPGKGTLLGDILRVFSQLGSLLKNCDISLHLVEVSQKLSEIQALTLTEEKVPLERNAESPVYMKGVTKSGIPVSWYRDLQDVPKEYSFYLAHEFFDVLPVHKFQKTPHGWREVLVDIDPQVSDKLRFVLAPCATPAEAFIQNDETRDHVEVCPEAGVVIQELSQRISLTGGAALIADYGHDGTKTDTFRGFCGHRLHDVLTAPGTADLTADVDFSYLRRMSQGKVASLGPVEQQTFLRNMGIDVRLKILLDKTDDPSLRQQLLQGYNMLMNPMKMGERFNFLALVPHQRLHGRNHQTNARQSKPSPSPVAGFGELAWQ", "length": 441, "header": "tr|F1MJQ5-1|F1MJQ5_BOVIN Isoform 1 of Protein arginine methyltransferase NDUFAF7 OS=Bos taurus OX=9913 GN=NDUFAF7 PE=3 SV=2 CANONICAL=F1MJQ5-1" }, "locus": { "chromosome": "11", "start_pos": 19675614, "end_pos": 19659213, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001470.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001470.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001470.5", "url": "https://www.ensembl.org/id/ENSBTAP00000001470.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 257, "start_aa": "Thr", "end_pos": 257, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr257", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QDK9-1", "protein_name": "Protein arginine methyltransferase NDUFAF7", "gene_name": "NDUFAF7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSVLARVAAGRLAAARAVIPCLWRGQYFSSGKEPAEDNSVTPMLRHLIYKIKSTGPITVAEYMREVLTNPAKGYYVTRDMLGEKGDFITSPEISQIFGELLGIWFISEWIATGKNAAFQLVELGPGRGTLSGDILRVFSQLGSVLKNCDISIHLVEVSQKLSEIQALTLTEEKVPLEREAGSPVYMKGVTKSGIPISWYRDLQDVPKGYSFYLAHEFFDVLPVHKFQKTPQGWREVLIDIDPQVSDKLRFVLAPCATPAEAFIQKDETRDHVEVCPDAGVIIQELAQRISLTGGAALIADYGHDGTKTDTFRGFCGHQLHDVLIAPGTADLTADVDFSYLRRMSQGKVASLGPISQQTFLRNMGIDVRLKILLDKSDEPSLREQLLQGYRMLMNPEKMGERFNFFALVPHQRLHGRHHQMNACQSKPSPSPVAGFGELVWR", "length": 441 }, "evidence": [ { "id": "F1MJQ5", "url": "https://omabrowser.org/oma/group/F1MJQ5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XS06-1", "protein_name": "Protein arginine methyltransferase NDUFAF7", "gene_name": "NDUFAF7", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQPIMPPPPACRALLATALGLAGRHRLPCHRAPLAARLSSGAGGEVEAAGSGEAGGVLRHLLLKLRATGPVTVAEYMREALTNPGQGYYTRRGGVGEDFITSPEISQIFGELIGIWYISEWMAMGKQNAFQLVELGPGMGTLTGDILRVFNQLASLLSKCDVSIHLVEVSPKLSAIQAEMLTGGKVQSNPENKSAYMKGISKTGIPIYWYRDIQDVPQGYSFYLAHEFLDALPIHKFQRTEKGWHEVLVDIDPEVPDQLRFVLSPSRTPATENFIQPEETRDHVEVCPEAGVLIQRLACRIEKDGGAALIADYGHDGTKTDTFRGFRNHKLHDVLKAPGTADLTADVDFSYLRKMAEGRTATLGPIKQREFLKNMGIDLRLQVLLQHSRDSATHEQLLHSFDMLMNPKKMGDCFHFFALLPHHRVVRPTKKDNPQSKSPLPPVAGFGELSLK", "length": 452 }, "evidence": [ { "id": "F1MJQ5", "url": "https://omabrowser.org/oma/group/F1MJQ5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q08BY0-1", "protein_name": "Protein arginine methyltransferase NDUFAF7, mitochondrial", "gene_name": "ndufaf7", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRTLLRLKRLMPEVLWTKRSCSSSSINKSILKHLASKIIATGPISVAEYMREALTNPVLGYYVKNDMLGAGGDFITSPEISQIFGELLGVWCISEWMAAGKSSALQLVELGPGRGSLTSDILRVFSQLKGVLGETGISIHLVEVSPKLSQVQAECLTGNQTQTYDNNHTFYRSGTTCTGLPIYWYHSIEDVPRGFSIFLAHEFFDALPIHKFQRTENGWREVLVDIDPENPGKLRFVVSHRPTLASSTLIQKDESRRHVEVCAEAGVIVQKLASRIAEDGGAALIVDYGHDGTKTDTFRGFKGHQIHDVLEAPGLADLTADVDFSYLRKMAGDQVICLGPITQRSFLKNMGIDSRMQVLLSSNDPSIRAQLIHSYDMLINPEKMGERFQFFSVLNTARLAQREQMQKSTVMPVAGFTELEMQ", "length": 422 }, "evidence": [ { "id": "F1MJQ5", "url": "https://omabrowser.org/oma/group/F1MJQ5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q54S83-1", "protein_name": "Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial", "gene_name": "midA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFRSITQRVIRNNCYKQSTKSITSSTSFINNSLSYTTTSNENDIKDKNEEHDHRAKGKGRELLLSFDKSGLAQFPKQVFKNRKYPITDFEKYLQDITKVRGPMSIDTFIKEVLTNPKYGYYMNKDVFGKGGDFITAPEVSQLFGEMIGIWCVATWEAMGKPKKLQIVEMGPGRGTLMKDILRSTKVFKEFYDSISVHLVEASPANKKTQKQNLLYFKDKAINFDHKTIGETPNGIKVTWVGKLEEVPTDIPTLFLAQEFFDALPIHVFRFSREKNDWCEVLVDEDITEHGEYYLRFVQSKGPTLMTTAVKHLLPEFGLDGYQVELGLAGLAISQQIANRIDKSGGAALIIDYGYDKIVKSSLQAIRDHEFVDILDKPGTADLSVWVDFQTIRKTVKLLKNKSTAIGPVDQGIFLKEMGIEHRLAQIGRKLDSNEKFEELVMGYKKLVDPKEMGTNYKVITICDKNITPIGFSTSKTYDDEDLMI", "length": 484 }, "evidence": [ { "id": "F1MJQ5", "url": "https://omabrowser.org/oma/group/F1MJQ5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5XI79-1", "protein_name": "Protein arginine methyltransferase NDUFAF7, mitochondrial", "gene_name": "Ndufaf7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNALVRRCVARTGIPSIWRRKCFSSGNEPAESNHVTPMLRHLMYKIKSTGPITVAEYMKEVLTNPAKGYYVHHDMLGEKGDFITSPEISQIFGELLGVWFVSEWMASGKSTAFQLVELGPGRGTLTADILRVFSQLGSVLKTCDISIHLVEVSQKLSEIQALTLTEETVPLERDAESLVYMKGVTKSGIPISWYRDLKDVPTGYSFYLAHEFFDVLPVHKFQKTPHGWREVFVDIDPQSPDKLRFVLAPCATPAEAFIQRDERREHVEVCPDAGVVIQELSQRIASTGGAALIADYGHDGTKTDTLRGFYEHQLHDVLTAPGTADLTADVDFSYLRRMAQGRVASLGPVEQRTFLKNMGIDVRLKVLLDKAGDPSLQQQLLRGYDMLMNPQKMGERFHFFALLPHQRLHVGSQGGKACQSEAPSTSVPGFDELVWH", "length": 436 }, "evidence": [ { "id": "F1MJQ5", "url": "https://omabrowser.org/oma/group/F1MJQ5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7L592-1", "protein_name": "Protein arginine methyltransferase NDUFAF7, mitochondrial", "gene_name": "NDUFAF7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSVLLRSGLGPLCAVARAAIPFIWRGKYFSSGNEPAENPVTPMLRHLMYKIKSTGPITVAEYMKEVLTNPAKGYYVYRDMLGEKGDFITSPEISQIFGELLGIWFISEWMATGKSTAFQLVELGPGRGTLVGDILRVFTQLGSVLKNCDISVHLVEVSQKLSEIQALTLTKEKVPLERNAGSPVYMKGVTKSGIPISWYRDLHDVPKGYSFYLAHEFFDVLPVHKFQKTPQGWREVFVDIDPQVSDKLRFVLAPSATPAEAFIQHDETRDHVEVCPDAGVIIEELSQRIALTGGAALVADYGHDGTKTDTFRGFCDHKLHDVLIAPGTADLTADVDFSYLRRMAQGKVASLGPIKQHTFLKNMGIDVRLKVLLDKSNEPSVRQQLLQGYDMLMNPKKMGERFNFFALLPHQRLQGGRYQRNARQSKPFASVVAGFSELAWQ", "length": 441 }, "evidence": [ { "id": "F1MJQ5", "url": "https://omabrowser.org/oma/group/F1MJQ5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CWG8-1", "protein_name": "Protein arginine methyltransferase NDUFAF7, mitochondrial", "gene_name": "Ndufaf7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNALVRRCVARAGLPCIWRGKCYSSGNEPAESNQVTPMLRHLMYKIKSTGPITVAEYMKEVLTNPAKGYYVHQDMLGEKGDFITSPEISQIFGELLGVWFVSEWIASGKSPAFQLVELGPGRGTLTADILRVFSQLGSVLKTCAISIHLVEVSQKLSEIQALTLAEEKVPLERDAESLVYMKGVTKSGIPVSWYRDLKDVPEGYSLYLAHEFFDVLPVHKFQKTPRGWREVFVDVDPQASDKLRFVLAPCATPAEAFIQRDERREHVEVCPDAGVIIQELSQRIASTGGAALIADYGHDGTKTDTLRGFYGHQLHDVLIAPGTADLTADVDFSYLRRMAQGKVASLGPVEQRTFLKNMGIDVRLKVLLDKAGEPSAKQQLLGGYDMLMNPQKMGERFHFFALLPHQRLHGGSQERNACQSKTPSSSVAGFDELVWQ", "length": 436 }, "evidence": [ { "id": "F1MJQ5", "url": "https://omabrowser.org/oma/group/F1MJQ5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VGR2-1", "protein_name": "Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLREALRIGNRRWYSYKSVRRPNLGATGTPKMEPPKEQPEASSKAESGHGSLAKQLRAKILSTGPIPVAEYMREVLTNPQAGYYMNRDVFGREGDFITSPEISQIFGELVGIWLVSEWRKMGSPSPFQLVELGPGRGTLARDVLKVLTKFKQDAEFSMHMVEVSPFLSKAQAQRFCYSHQTLPEDAQLPHYQEGTTASGTKAFWHRRLEDVPQGFSLVLAHEFFDALPVHKLQLVDGKWQEVLIDVASSDGAQEASFRYVLSRSQTPVSSLYRPLPGETRSCLEHSLETERQVGLLAERIERDGGIALIMDYGHFGEKTDTFRAFKQHKLHDPLVEPGSADLTADVDFKLVRHIAETRGNVHCCGPVEQGLFLQRMQGEARLEQLLAHALPENQEIIRSGYEMLTDPAQMGTRFKFLAMFPGVLAAHLDKYPVVGFS", "length": 437 }, "evidence": [ { "id": "F1MJQ5", "url": "https://omabrowser.org/oma/group/F1MJQ5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ5", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ5", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ5", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-arginine omega-N symmetric methyltransferase activity", "id": "GO:0035243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035243", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ5", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ], "pmid": "" }, { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ5", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 37, "end_pos": 39, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "48108", "name": "", "equation": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJQ5-1", "A0AAA9TZG3-1", "A7YW45-1", "Q2KHV5-1" ], "evidence": [ { "id": "48108", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48108" } ] }, { "id": "R-BTA-6799178", "name": "Intermediate 1 binds HP subcomplex to form Intermediate 2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P17694-1", "P42028-1", "F1MJQ5-1" ], "evidence": [ { "id": "R-BTA-6799178", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799178" } ] }, { "id": "R-BTA-6799179", "name": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P15690-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "P04394-1", "Q6QTH1-1", "Q85BD6-1", "F1MJQ5-1", "P25708-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799179", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799179" } ] }, { "id": "R-BTA-6799191", "name": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P17694-1", "P42028-1", "Q6QTH1-1", "F1MJQ5-1" ], "evidence": [ { "id": "R-BTA-6799191", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799191" } ] }, { "id": "R-BTA-6799196", "name": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P15690-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "P04394-1", "Q6QTH1-1", "Q85BD6-1", "F1MJQ5-1", "P25708-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799196", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799196" } ] }, { "id": "R-BTA-6799197", "name": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P17694-1", "P03898-1", "P03910-1", "P03924-1", "P42028-1", "Q6QTH1-1", "Q85BD6-1", "F1MJQ5-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799197", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799197" } ] }, { "id": "R-BTA-6799202", "name": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P17694-1", "P03898-1", "P03924-1", "P42028-1", "Q6QTH1-1", "F1MJQ5-1", "A0A3Q1MP25-1", "Q6QTH0-1" ], "evidence": [ { "id": "R-BTA-6799202", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799202" } ] }, { "id": "R-BTA-6799203", "name": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P17694-1", "P42028-1", "F1MJQ5-1" ], "evidence": [ { "id": "R-BTA-6799203", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799203" } ] }, { "id": "R-BTA-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P42026-1", "P17694-1", "P42028-1", "F1MJQ5-1" ], "evidence": [ { "id": "R-BTA-6800868", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6800868" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MP25", "gene_name": "ACAD9", "activity": [ { "ec_number": "1.3.8.7", "activity": "a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] }, { "ec_number": "1.3.8.8", "activity": "a long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] }, { "ec_number": "1.3.8.7", "activity": "", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] }, { "ec_number": "1.3.8.8", "activity": "", "evidence": [ { "id": "A0A3Q1MP25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP25" } ] } ] }, { "uniprot_ac": "A0AAA9TZG3", "gene_name": "PRMT5", "activity": [ { "ec_number": "2.1.1.320", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "A0AAA9TZG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZG3" } ] }, { "ec_number": "2.1.1.320", "activity": "", "evidence": [ { "id": "A0AAA9TZG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZG3" } ] } ] }, { "uniprot_ac": "A7YW45", "gene_name": "PRMT5", "activity": [ { "ec_number": "2.1.1.320", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "A7YW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YW45" } ] }, { "ec_number": "2.1.1.320", "activity": "", "evidence": [ { "id": "A7YW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YW45" } ] } ] }, { "uniprot_ac": "F1MJQ5", "gene_name": "NDUFAF7", "activity": [ { "ec_number": "2.1.1.320", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "F1MJQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ] }, { "ec_number": "2.1.1.320", "activity": "", "evidence": [ { "id": "F1MJQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ5" } ] } ] }, { "uniprot_ac": "P03898", "gene_name": "MT-ND3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03898" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03898" } ] } ] }, { "uniprot_ac": "P03910", "gene_name": "MT-ND4", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03910" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03910" } ] } ] }, { "uniprot_ac": "P03924", "gene_name": "MT-ND6", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P03924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03924" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P03924" } ] } ] }, { "uniprot_ac": "P04394", "gene_name": "NDUFV2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P04394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04394" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P04394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04394" } ] } ] }, { "uniprot_ac": "P15690", "gene_name": "NDUFS1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P15690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P15690" } ] } ] }, { "uniprot_ac": "P17694", "gene_name": "NDUFS2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P17694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P17694" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P17694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P17694" } ] } ] }, { "uniprot_ac": "P25708", "gene_name": "NDUFV1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P25708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25708" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P25708", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P25708" } ] } ] }, { "uniprot_ac": "P42026", "gene_name": "NDUFS7", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P42026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42026" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P42026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42026" } ] } ] }, { "uniprot_ac": "P42028", "gene_name": "NDUFS8", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "P42028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42028" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P42028", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P42028" } ] } ] }, { "uniprot_ac": "Q2KHV5", "gene_name": "NDUFAF7", "activity": [ { "ec_number": "2.1.1.320", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "Q2KHV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHV5" } ] }, { "ec_number": "2.1.1.320", "activity": "", "evidence": [ { "id": "Q2KHV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KHV5" } ] } ] }, { "uniprot_ac": "Q6QTH0", "gene_name": "ND2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "Q6QTH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q6QTH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH0" } ] } ] }, { "uniprot_ac": "Q6QTH1", "gene_name": "ND1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "Q6QTH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q6QTH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6QTH1" } ] } ] }, { "uniprot_ac": "Q85BD6", "gene_name": "ND5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out).", "evidence": [ { "id": "Q85BD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q85BD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q85BD6" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJQ5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 441, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJQ5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJQ5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.1.1.320", "ec_name": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+).", "evidence": [ { "id": "2.1.1.320", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320" }, { "id": "2.1.1.320", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.320" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 257 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 37, "end_pos": 39 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMH7-1", "uniprot_ac": "F1MMH7", "uniprot_id": "F1MMH7_BOVIN", "mass": { "chemical_mass": 50711.0, "monoisotopic_mass": 50711.0 }, "refseq": {}, "gene_names": [ { "name": "SLC38A11", "type": "recommended", "evidence": [ { "id": "F1MMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMH7" } ] } ], "protein_names": [ { "name": "Putative sodium-coupled neutral amino acid transporter 11", "type": "recommended", "evidence": [ { "id": "F1MMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMH7/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 38 member 11", "type": "synonym", "evidence": [ { "id": "F1MMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMH7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Putative sodium-dependent amino acid/proton antiporter.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1N5C4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5C4#function" }, { "database": "UniProtKB", "id": "ARBA00037101", "url": "https://www.uniprot.org/uniprotkb/ARBA00037101#function" }, { "database": "UniProtKB", "id": "A0AAA9T311", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T311#function" }, { "database": "UniProtKB", "id": "A0AAA9T9N6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9N6#function" }, { "database": "UniProtKB", "id": "A0AAA9TVK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVK5#function" }, { "database": "UniProtKB", "id": "F1MMH7", "url": "https://www.uniprot.org/uniprotkb/F1MMH7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMH7", "url": "https://www.uniprot.org/uniprotkb/F1MMH7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC38A11", "url": "https://www.uniprot.org/uniprotkb/F1MMH7", "locus": { "chromosome": "2", "start_pos": 31348547, "end_pos": 31290418, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007650", "url": "https://www.ensembl.org/id/ENSBTAG00000007650" } ] } } ], "crossref": [ { "id": "F1MMH7", "url": "https://alphafold.ebi.ac.uk/entry/F1MMH7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007650", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007650", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "523418", "url": "https://www.ncbi.nlm.nih.gov/gene/523418", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "FLFFGSQ", "url": "https://omabrowser.org/oma/group/FLFFGSQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N5C4", "url": "https://www.orthodb.org/?gene=A0A3Q1N5C4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MMH7", "url": "https://www.orthodb.org/?gene=F1MMH7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22950", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22950", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22950:SF458", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22950:SF458", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01490", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01490", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1N5C4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5C4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N5C4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5C4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T311", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T311", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T311-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T311-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9N6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9N6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T9N6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9N6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVK5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TVK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMH7", "url": "https://www.uniprot.org/uniprotkb/F1MMH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMH7-1", "url": "https://www.uniprot.org/uniprotkb/F1MMH7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGYPGQRPVIPPQSHRDDRETLVSEHKHKGKTCRQSAAVFNVVNSIIGSGIIGLPYSMKQAGFPLGILLLFWVSYVTDFSLILLIKGAALSGTDTYQSLVNRTFGFPGYLLLSVLQFLYPFIAMISYNIITGDTLSKVFQRIPGVDPENLLIGRHLIIVLSTVVFTLPLSLYRDIAKLGKISLISTVLTTLILGIVVARGVSLGPHIPKTEDAWIFAKPNAVQAVGVMSFAFICHHNCFLVYGSLEEPTVAKWSHIIHVSTLISVFISILFATCGYLTFTGYTQGDLFENYCRNDDLVTFGRFCYGVTVILTYPIECFVTREVIANVFFGGNLSSVCHIIVTVVIITVATLVSLLIDCLGIVLELNGVLCAAPLIFIIPSACYLKLSEEPRTHSDKIMSCVMLPIGAVVMAVGFVMAVTSPQDCSHGQEMFYCSPDNFSLTNISISHLQLTTQLSILNVSIFQ", "length": 463, "header": "tr|F1MMH7-1|F1MMH7_BOVIN Isoform 1 of Putative sodium-coupled neutral amino acid transporter 11 OS=Bos taurus OX=9913 GN=SLC38A11 PE=3 SV=1 CANONICAL=F1MMH7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N5C4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5C4/entry", "sequence": { "sequence": "MGYPGQRPVIPPQSHRDDRETLVSEHKHKGKTCRQSAAVFNVVNSIIGSGIIGLPYSMKQAGFPLGILLLFWVSYVTDFSLILLIKGAALSGTDTYQSLVNRTFGFPGYLLLSVLQFLYPFIAMISYNIITGDTLSKVFQRIPGVDPENLLIGRHLIIVLSTVVFTLPLSLYRDIAKLGKISLISTVLTTLILGIVVARGVSLGPHIPKTEDAWIFAKPNAVQAVGVMSFAFICHHNCFLVYGSLEEPTVAKWSHIIHVSTLISVFISILFATCGYLTFTGYTQGDLFENYCRNDDLVTFGRFCYGVTVILTYPIECFVTREVIANVFFGGNLSSVCHIIVTVVIITVATLVSLLIDCLGIVLELNGVLCAAPLIFIIPSACYLKLSEEPRTHSDKIMSCVMLPIGAVVMAVGFVMAVTSPQDCSHGQEMFYCSPDNFSLTNISISHLQLTTQLSILNDSEIQVIQPGKSQLVLLWSHTVQHTSP", "length": 485, "header": "tr|A0A3Q1N5C4-1|F1MMH7_BOVIN Computationally mapped isoform of Putative sodium-coupled neutral amino acid transporter 11 OS=Bos taurus OX=9913 GN=SLC38A11 PE=3 SV=1 CANONICAL=F1MMH7-1" }, "locus": { "chromosome": "2", "start_pos": 31348513, "end_pos": 31290549, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068522.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068522.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065345.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065345.1" } ] } }, { "isoform_ac": "A0AAA9T311-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T311/entry", "sequence": { "sequence": "MGYPGQRPVIPPQSHRDDRETLVSEHKHKGKTCRQSAAVFNVVNSIIGSGIIDFSLILLIKGAALSGTDTYQSLVNRTFGFPGYLLLSVLQFLYPFIAMISYNIITGDTLSKVFQRIPGVDPENLLIGRHLIIVLSTVVFTLPLSLYRDIAKLGKISLISTVLTTLILGIVVARGVSLGPHIPKTEDAWIFAKPNAVQAVGVMSFAFICHHNCFLVYGSLEEPTVAKWSHIIHVSTLISVFISILFATCGYLTFTGYTQGDLFENYCRNDDLVTFGRFCYGVTVILTYPIECFVTREVIANVFFGGNLSSVCHIIVTVVIITVATLVSLLIDCLGIVLELNGVLCAAPLIFIIPSACYLKLSEEPRTHSDKIMSCVMLPIGAVVMAVGFVMAVTSPQDCSHGQEMFYCSPDNFSLTNISISHLQLTTQLSILNVSIFQ", "length": 438, "header": "tr|A0AAA9T311-1|F1MMH7_BOVIN Computationally mapped isoform of Putative sodium-coupled neutral amino acid transporter 11 OS=Bos taurus OX=9913 GN=SLC38A11 PE=3 SV=1 CANONICAL=F1MMH7-1" }, "locus": { "chromosome": "2", "start_pos": 31345543, "end_pos": 31290549, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114945.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114945.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092132.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092132.1" } ] } }, { "isoform_ac": "A0AAA9T9N6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T9N6/entry", "sequence": { "sequence": "MGYPGQRPVIPPQSHRDDRETLVSEHKHKGKTCRQSAAVFNVVNSIIGSGIIGLPYSMKQAGFPLGILLLFWVSYVTDFSLILLIKGAALSGTDTYQSLVNRTFGFPGYLLLSVLQFLYPFIVDPENLLIGRHLIIVLSTVVFTLPLSLYRDIAKLGKISLISTVLTTLILGIVVARGVSLGPHIPKTEDAWIFAKPNAVQAVGVMSFAFICHHNCFLVYGSLEEPTVAKWSHIIHVSTLISVFISILFATCGYLTFTGYTQGDLFENYCRNDDLVTFGRFCYGVTVILTYPIECFVTREVIANVFFGGNLSSVCHIIVTVVIITVATLVSLLIDCLGIVLELNGVLCAAPLIFIIPSACYLKLSEEPRTHSDKIMSCVMLPIGAVVMAVGFVMAVTSPQDCSHGQEMFYCSPDNFSLTNISISHLQLTTQLSILNVSIFQ", "length": 441, "header": "tr|A0AAA9T9N6-1|F1MMH7_BOVIN Computationally mapped isoform of Putative sodium-coupled neutral amino acid transporter 11 OS=Bos taurus OX=9913 GN=SLC38A11 PE=3 SV=1 CANONICAL=F1MMH7-1" }, "locus": { "chromosome": "2", "start_pos": 31345543, "end_pos": 31290549, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135040.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135040.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092617.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092617.1" } ] } }, { "isoform_ac": "A0AAA9TVK5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVK5/entry", "sequence": { "sequence": "MGWQSQTRQRLNKSHRDDRETLVSEHKHKGKTCRQSAAVFNVVNSIIGSGIIGLPYSMKQAGFPLGILLLFWVSYVTDFSLILLIKGAALSGTDTYQSLVNRTFGFPGYLLLSVLQFLYPFIAMISYNIITGDTLSKVFQRIPGVDPENLLIGRHLIIVLSTVVFTLPLSLYRDIAKLGKISLISTVLTTLILGIVVARGVSLGPHIPKTEDAWIFAKPNAVQAVGVMSFAFICHHNCFLVYGSLEEPTVAKWSHIIHVSTLISVFISILFATCGYLTFTGYTQGDLFENYCRNDDLVTFGRFCYGVTVILTYPIECFVTREVIANVFFGGNLSSVCHIIVTVVIITVATLVSLLIDCLGIVLELNGVLCAAPLIFIIPSACYLKLSEEPRTHSDKIMSCVMLPIGAVVMAVGFVMAVTSPQDCSHGQEMFYCSPDNFSLTNISISHLQLTTQLSILNVSIFQ", "length": 463, "header": "tr|A0AAA9TVK5-1|F1MMH7_BOVIN Computationally mapped isoform of Putative sodium-coupled neutral amino acid transporter 11 OS=Bos taurus OX=9913 GN=SLC38A11 PE=3 SV=1 CANONICAL=F1MMH7-1" }, "locus": { "chromosome": "2", "start_pos": 31345543, "end_pos": 31290844, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097237.1", "url": "https://www.ensembl.org/id/ENSBTAT00000097237.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101447.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101447.1" } ] } }, { "isoform_ac": "F1MMH7-1", "url": "https://www.uniprot.org/uniprotkb/F1MMH7/entry", "sequence": { "sequence": "MGYPGQRPVIPPQSHRDDRETLVSEHKHKGKTCRQSAAVFNVVNSIIGSGIIGLPYSMKQAGFPLGILLLFWVSYVTDFSLILLIKGAALSGTDTYQSLVNRTFGFPGYLLLSVLQFLYPFIAMISYNIITGDTLSKVFQRIPGVDPENLLIGRHLIIVLSTVVFTLPLSLYRDIAKLGKISLISTVLTTLILGIVVARGVSLGPHIPKTEDAWIFAKPNAVQAVGVMSFAFICHHNCFLVYGSLEEPTVAKWSHIIHVSTLISVFISILFATCGYLTFTGYTQGDLFENYCRNDDLVTFGRFCYGVTVILTYPIECFVTREVIANVFFGGNLSSVCHIIVTVVIITVATLVSLLIDCLGIVLELNGVLCAAPLIFIIPSACYLKLSEEPRTHSDKIMSCVMLPIGAVVMAVGFVMAVTSPQDCSHGQEMFYCSPDNFSLTNISISHLQLTTQLSILNVSIFQ", "length": 463, "header": "tr|F1MMH7-1|F1MMH7_BOVIN Isoform 1 of Putative sodium-coupled neutral amino acid transporter 11 OS=Bos taurus OX=9913 GN=SLC38A11 PE=3 SV=1 CANONICAL=F1MMH7-1" }, "locus": { "chromosome": "2", "start_pos": 31345543, "end_pos": 31290549, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010065.5", "url": "https://www.ensembl.org/id/ENSBTAT00000010065.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010065.3", "url": "https://www.ensembl.org/id/ENSBTAP00000010065.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A287AJN0-1", "protein_name": "Putative sodium-coupled neutral amino acid transporter 11", "gene_name": "SLC38A11", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGYQGQRPAILPQSDLDDRENLVSEHSHKGKACRQSAAVFNVVNSIIGSGIIGLPYSMKQAGFPLGILLLFWVSYVTDFSLVLLIKGGALSGTDTYQSLVNKTFGFPGYLLLSVLQFLYPFIAMISYNIVTGDTLSKVFQRLPGVDPENLLIGRHFIIVLSTIAFTLPLSLYRDIAKLGKISLISTVLTTLILGIVMTRVVSLGPHIPKTEDAWIFAKPNAIQAVGVMSFAFICHHNCFLVYGSLEEPTVTKWSHIIHVSTSISVFISILFATCGYLTFTGFTQGDLFENYCRNDDLVTFGRFCYGITVILTYPIECFVTREVIANVFFSGNLSSVLHIIITVAIITVATLVSLLVDCLGIVLELNGVLCAAPLIFIIPSACYLKLSEEPRTHSDKIMSCVMLPIGAVVMVVGFVMAITNPQDCTHGQEMFYCFSDNFSLTNISISHFQLTTQLSILNISIFQ", "length": 463 }, "evidence": [ { "id": "F1MMH7", "url": "https://omabrowser.org/oma/group/F1MMH7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3Z813-1", "protein_name": "Putative sodium-coupled neutral amino acid transporter 11", "gene_name": "Slc38a11", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSYQQPQLRGPLQRETDPSDRESLVSGHEHGGKSSQSAAVFNVVNSVIGSGIIGLPYSMKQAGFPLGILLLFWVSYITDFSLVLLIKGGALSGTDSYQSLVNKTFGFPGYLLLSTLQFMYPFIAMISYNIITGDTLSKVFQRLPGVDPGSWFISRHFIIVVSTVTCTLPLSLYRDIAKLGKISFISTILTAVILGVVVTRTISLGPNIPKTDNAWVFARPNAIQAIGVMSFAFICHHNCFLVYGSLEEPTVAKWRRVIHTSILVSVFICVLFATCGYFTFTGFTQGDLFENYCRSDDLVTFGRFCYGITVILTYPIECFVTREVITNVFFGGALSSVFHVTLTAAIVTAATLISLLIDCLGIVLELNGVLCAAPLIFIIPSACYLKLSEEPRTHSDKLMACVMFPVGAVVMVAGFVMAITNPQDCTHGQEMFYCFPDNISLTNISHSPRQLTA", "length": 453 }, "evidence": [ { "id": "F1MMH7", "url": "https://omabrowser.org/oma/group/F1MMH7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P39981-1", "protein_name": "Vacuolar amino acid transporter 2", "gene_name": "AVT2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSELGEYSKLENKELRTEFELTNFPFPGTTDNDSDDGSQGQNSLNIITPDMDDTLVNDVLRENDKKSSMRMAFMNLANSILGAGIITQPFAIKNAGILGGLLSYVALGFIVDWTLRLIVINLTLAGKRTYQGTVEHVMGKKGKLLILFTNGLFAFGGCIGYCIIIGDTIPHVLRAIFSQNDGNVHFWLRRNVIIVMVTTFISFPLSMKRNIEALSKASFLAVISMIIIVLTVVIRGPMLPYDWKGHSLKLSDFFMKATIFRSLSVISFALVCHHNTSFIFFSMRNRSVAKFTRLTHISIIISVICCALMGYSGFAVFKEKTKGNVLNSFPGTDTAINIARLCFGFNMLTTFPMEIFVLRDVVGNLLHECNLIKNYDEHTQLSGKQHVVITSSLVFITMGISLTTCNLGALFELIGATTASTMAYILPPYTNLLLTSKKKSWKERLPFYLCICFGFMIMIISSTQTIIDAVNGSDGQHCQI", "length": 480 }, "evidence": [ { "id": "F1MMH7", "url": "https://omabrowser.org/oma/group/F1MMH7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q08AI6-1", "protein_name": "Putative sodium-coupled neutral amino acid transporter 11", "gene_name": "SLC38A11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKQAGFPLGILLLFWVSYVTDFSLVLLIKGGALSGTDTYQSLVNKTFGFPGYLLLSVLQFLYPFIAMISYNIIAGDTLSKVFQRIPGVDPENVFIGRHFIIGLSTVTFTLPLSLYRNIAKLGKVSLISTGLTTLILGIVMARAISLGPHIPKTEDAWVFAKPNAIQAVGVMSFAFICHHNSFLVYSSLEEPTVAKWSRLIHMSIVISVFICIFFATCGYLTFTGFTQGDLFENYCRNDDLVTFGRFCYGVTVILTYPMECFVTREVIANVFFGGNLSSVFHIVVTVMVITVATLVSLLIDCLGIVLELNGVLCATPLIFIIPSACYLKLSEEPRTHSDKIMSCVMLPIGAVVMVFGFVMAITNTQDCTHGQEMFYCFPDNFSLTNTSESHVQQTTQLSTLNISIFQ", "length": 406 }, "evidence": [ { "id": "F1MMH7", "url": "https://omabrowser.org/oma/group/F1MMH7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3USY0-1", "protein_name": "Putative sodium-coupled neutral amino acid transporter 11", "gene_name": "Slc38a11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSYQQPQLSGPLQRETDSSDRESLISGHEHGGKSSQSAAVFNVVNSVIGSGIIGLPYSMKQAGFPLGILLLFLVSYITDFSLVLLIKGGALSGTDSYQSLVNKTFGFPGYLLLSTLQFMYPFIAMISYNIITGDTLSKVFQRLPGVDPGGWFISRHFIIVVSTVTCTLPLSLYRDIAKLGKISFISTILTTVILGIVMTRAISLGPNIPKTDNAWVFAKPNAIQAIGVMSFAFICHHNCFLVYGSLEEPTVAKWRRIIHTSILVSVFICVLFATCGYFTFTGFTQGDLFENYCRSDDLVTFGRFCYGITVILTYPIECFVTREVIANVFFGGTLSSVFHTVLAVLIVTAATLVSLMIECLGIVLELNGVLCAAPLIFIIPSACYLKLSEEPRTHSDKIMACVMFPVGAVVMVVGFVMAITNPQDCTHGQEMFYCFPENVSFTNTSWSHLQLTT", "length": 453 }, "evidence": [ { "id": "F1MMH7", "url": "https://omabrowser.org/oma/group/F1MMH7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9M8L9-1", "protein_name": "Amino acid transporter AVT6E", "gene_name": "AVT6E", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDSSYSVISKTSYVELQKPTVNGKPRNKLLPSDEESFVNDFDDARNGVGGEDADDLDFDVADYPLVHGKSSNQGSGIYGAVFNLTTSIIGAGIMALPATMKVLGLVLGFVLIILMALLSEISVELLVRFSVLYKSKSYGEVVQFALGKTARVLSEICIIVNNGGVLVVYLIIMGDVMSGSLHHIGVLDQWLGNGFWDHRKVLILIVMVIFLAPLCALNKIDSLSVTSAASVALAVVFVVVCFVVATIKLIEGTIDPPRLSPDFGSKQAILDLLVVIPIMSNAYVCHFNVQPIYNELEGRSPHKMNRVGRITTAICVVVYASTAVSGYLLFGKDTESDILTNFDQDLGIRFSSAVNYIVRIGYILHLVLVFPVIHFSLRETVNTLLFEGSPPLSESKKRSLGLTVVLLALIYIGSTMIPNIWTAFKFTGATSAVSLGFTFPALIALRLGKQSNSLSFVERSVSWLMLILAVVVSIVGTIGNIYSLESKSD", "length": 489 }, "evidence": [ { "id": "F1MMH7", "url": "https://omabrowser.org/oma/group/F1MMH7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "L-amino acid transmembrane transporter activity", "id": "GO:0015179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015179", "evidence": [ { "database": "UniProtKB", "id": "F1MMH7", "url": "https://www.uniprot.org/uniprotkb/F1MMH7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MMH7", "url": "https://www.uniprot.org/uniprotkb/F1MMH7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "amino acid transmembrane transport", "id": "GO:0003333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003333", "evidence": [ { "database": "UniProtKB", "id": "F1MMH7", "url": "https://www.uniprot.org/uniprotkb/F1MMH7" } ], "pmid": "" }, { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { "database": "UniProtKB", "id": "F1MMH7", "url": "https://www.uniprot.org/uniprotkb/F1MMH7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 437, "end_pos": 439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 442, "end_pos": 444, "annotation": "n_glycosylation_sequon" }, { "start_pos": 458, "end_pos": 460, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MMH7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 463, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MMH7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MMH7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMH7" }, { "id": "PF01490", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01490" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amino acid transporter transmembrane", "eco_id": "ECO_0000259", "start_pos": 38, "end_pos": 417, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 437, "end_pos": 439 }, { "start_pos": 442, "end_pos": 444 }, { "start_pos": 458, "end_pos": 460 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MT69-1", "uniprot_ac": "F1MT69", "uniprot_id": "F1MT69_BOVIN", "mass": { "chemical_mass": 43759.0, "monoisotopic_mass": 43759.0 }, "refseq": {}, "gene_names": [ { "name": "VPS36", "type": "recommended", "evidence": [ { "id": "F1MT69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT69" } ] } ], "protein_names": [ { "name": "Vacuolar protein-sorting-associated protein 36", "type": "recommended", "evidence": [ { "id": "F1MT69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT69/entry#names_and_taxonomy" } ] }, { "name": "ESCRT-II complex subunit VPS36", "type": "synonym", "evidence": [ { "id": "F1MT69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT69/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1N5G5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5G5#function" }, { "database": "UniProtKB", "id": "RU367095", "url": "https://www.uniprot.org/uniprotkb/RU367095#function" }, { "database": "UniProtKB", "id": "A0AAA9S9S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9S6#function" }, { "database": "UniProtKB", "id": "ARBA00053606", "url": "https://www.uniprot.org/uniprotkb/ARBA00053606#function" }, { "database": "UniProtKB", "id": "F1MT69", "url": "https://www.uniprot.org/uniprotkb/F1MT69#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MT69", "url": "https://www.uniprot.org/uniprotkb/F1MT69" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VPS36", "url": "https://www.uniprot.org/uniprotkb/F1MT69", "locus": { "chromosome": "12", "start_pos": 21646981, "end_pos": 21615450, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004307", "url": "https://www.ensembl.org/id/ENSBTAG00000004307" } ] } } ], "crossref": [ { "id": "F1MT69", "url": "https://alphafold.ebi.ac.uk/entry/F1MT69", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004307", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004307", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13226", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13226", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511223", "url": "https://www.ncbi.nlm.nih.gov/gene/511223", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021648", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021648", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037855", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037855", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "TLNARVW", "url": "https://omabrowser.org/oma/group/TLNARVW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N5G5", "url": "https://www.orthodb.org/?gene=A0A3Q1N5G5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MT69", "url": "https://www.orthodb.org/?gene=F1MT69", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13128", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13128", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13128:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13128:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04157", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04157", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11605", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11605", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-917729", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917729", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1N5G5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N5G5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5G5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9S6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9S6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9S6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MT69", "url": "https://www.uniprot.org/uniprotkb/F1MT69", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MT69-1", "url": "https://www.uniprot.org/uniprotkb/F1MT69-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDRFVWTSGLLEINETLVIQQRGVRIYDGEEKIKFDPGTLLLSTHRLIWRDQKNHECCMAIPLSQIVFIEEQAAGIGKSAKIVVHLHPAASNKEPGPFQSSKNSYIKLSFKEHGQIEFYRRLSEEMTQRRWENMPVPQSLQTNRGPQPGRIRAVGIVGIERKLEEKRKETDKNISEAFEDLSKLMVKAKEMVELSKSIANKIKDKQGDITEDETIRFKSYLLSMGIANPVTRETYGSGTQYHMQLAKQLAGILQAPLEERGGIMSLTEVYCLVNRARGMELLSPEDLVNACKMLEALKLPLRLRVFDSGVMVIELQSHKEEEMVASALETVSEKGSLTSEEFAKLVGMSVLLAKERLLLAEKMGHLCRDDSVEGLRFYPNLFMTQS", "length": 386, "header": "tr|F1MT69-1|F1MT69_BOVIN Isoform 1 of Vacuolar protein-sorting-associated protein 36 OS=Bos taurus OX=9913 GN=VPS36 PE=3 SV=1 CANONICAL=F1MT69-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N5G5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N5G5/entry", "sequence": { "sequence": "MDRFVWTSGLLEINETLVIQQRGVRIYDGEEKIKFDPGTLLLSTHRLIWRDQKNHECCMAIPLSQIVFIEEQAAGIGKSAKIVVHLHPAASNKEPGPFQSSKNSYIKLSFKEHGQIEFYRRLSEEMTQRRWENMPVPQSLQTNRGPQPGRIRAVGIVGIERKLEEKRKETDKNISEAFEDLSKLMVKAKEMVELSKSIANKIKDKQGDITEDETIRFKSYLLSMGIANPVTRETYGSGTQYHMQLAKQLAGILQAPLESLTPFMMWLLFNQHLLSPEDLVNACKMLEALKLPLRLRVFDSGVMVIELQSHKEEEMVASALETVSEKGSLTSEEFAKLVGMSVLLAKERLLLAEKMGHLCRDDSVEGLRFYPNLFMTQS", "length": 378, "header": "tr|A0A3Q1N5G5-1|F1MT69_BOVIN Computationally mapped isoform of Vacuolar protein-sorting-associated protein 36 OS=Bos taurus OX=9913 GN=VPS36 PE=3 SV=1 CANONICAL=F1MT69-1" }, "locus": { "chromosome": "12", "start_pos": 21644017, "end_pos": 21615506, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085822.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085822.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065419.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065419.1" } ] } }, { "isoform_ac": "A0AAA9S9S6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9S6/entry", "sequence": { "sequence": "MEQAVPGNPSVNHKEIKFDPGTLLLSTHRLIWRDQKNHECCMAIPLSQIVFIEEQAAGIGKSAKIVVHLHPAASNKEPGPFQSSKNSYIKLSFKEHGQIEFYRRLSEEMTQRRWENMPVPQSLQTNRGPQPGRIRAVGIVGIERKLEEKRKETDKNISEAFEDLSKLMVKAKEMVELSKSIANKIKDKQGDITEDETIRFKSYLLSMGIANPVTRETYGSGTQYHMQLAKQLAGILQAPLEERGGIMSLTEVYCLVNRARGMELLSPEDLVNACKMLEALKLPLRLRVFDSGVMVIELQSHKEEEMVASALETVSEKGSLTSEEFAKLVGMSVLLAKERLLLAEKMGHLCRDDSVEGLRFYPNLFMTQS", "length": 369, "header": "tr|A0AAA9S9S6-1|F1MT69_BOVIN Computationally mapped isoform of Vacuolar protein-sorting-associated protein 36 OS=Bos taurus OX=9913 GN=VPS36 PE=3 SV=1 CANONICAL=F1MT69-1" }, "locus": { "chromosome": "12", "start_pos": 21644017, "end_pos": 21616097, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124594.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124594.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082050.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082050.1" } ] } }, { "isoform_ac": "F1MT69-1", "url": "https://www.uniprot.org/uniprotkb/F1MT69/entry", "sequence": { "sequence": "MDRFVWTSGLLEINETLVIQQRGVRIYDGEEKIKFDPGTLLLSTHRLIWRDQKNHECCMAIPLSQIVFIEEQAAGIGKSAKIVVHLHPAASNKEPGPFQSSKNSYIKLSFKEHGQIEFYRRLSEEMTQRRWENMPVPQSLQTNRGPQPGRIRAVGIVGIERKLEEKRKETDKNISEAFEDLSKLMVKAKEMVELSKSIANKIKDKQGDITEDETIRFKSYLLSMGIANPVTRETYGSGTQYHMQLAKQLAGILQAPLEERGGIMSLTEVYCLVNRARGMELLSPEDLVNACKMLEALKLPLRLRVFDSGVMVIELQSHKEEEMVASALETVSEKGSLTSEEFAKLVGMSVLLAKERLLLAEKMGHLCRDDSVEGLRFYPNLFMTQS", "length": 386, "header": "tr|F1MT69-1|F1MT69_BOVIN Isoform 1 of Vacuolar protein-sorting-associated protein 36 OS=Bos taurus OX=9913 GN=VPS36 PE=3 SV=1 CANONICAL=F1MT69-1" }, "locus": { "chromosome": "12", "start_pos": 21644017, "end_pos": 21615506, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005646.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005646.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005646.4", "url": "https://www.ensembl.org/id/ENSBTAP00000005646.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-917729", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-917729", "resource": "Reactome", "description": "Endosomal Sorting Complex Required For Transport (ESCRT)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0XGX8-1", "protein_name": "Vacuolar protein-sorting-associated protein 36", "gene_name": "VPS36", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDRFSWTSGLLELGETLVLQQRGVRLYDGEEKVKFDSGVLLLSTHRLIWRDQKNHECCIAIPLSQVVFIEEQAAGIGKSAKIVAHLHPASPNKEPGPFQSSKYSYIKLSFKEHGQIEFFRRFSEEITQRRWENMPAGQTIQVNKDPQAGRIRAVGIVGIERKLEAKRKETDKNISEAFEDLSKLMEKAKEMVELSKSIANKIKEKQGDITEDETIRFKSYLLSMGIANPVTRETHGSGTHYHMQLAKQLAGMLQTPLEERGGIMSLTEVYCLVNRARGLELLSPEDLVNACKMLEPLKLPLRLQIFDSGVMVIELQSHNEEEMVASALETVSEKGSLTADEFAKLVGMSVLLAKERLLLAEKMGHLCRDDSVEGLRFYPNLFLTQS", "length": 386 }, "evidence": [ { "id": "F1MT69", "url": "https://omabrowser.org/oma/group/F1MT69/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q86VN1-1", "protein_name": "Vacuolar protein-sorting-associated protein 36", "gene_name": "VPS36", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDRFVWTSGLLEINETLVIQQRGVRIYDGEEKIKFDAGTLLLSTHRLIWRDQKNHECCMAILLSQIVFIEEQAAGIGKSAKIVVHLHPAPPNKEPGPFQSSKNSYIKLSFKEHGQIEFYRRLSEEMTQRRWENMPVSQSLQTNRGPQPGRIRAVGIVGIERKLEEKRKETDKNISEAFEDLSKLMIKAKEMVELSKSIANKIKDKQGDITEDETIRFKSYLLSMGIANPVTRETYGSGTQYHMQLAKQLAGILQVPLEERGGIMSLTEVYCLVNRARGMELLSPEDLVNACKMLEALKLPLRLRVFDSGVMVIELQSHKEEEMVASALETVSEKGSLTSEEFAKLVGMSVLLAKERLLLAEKMGHLCRDDSVEGLRFYPNLFMTQS", "length": 386 }, "evidence": [ { "id": "F1MT69", "url": "https://omabrowser.org/oma/group/F1MT69/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91XD6-1", "protein_name": "Vacuolar protein-sorting-associated protein 36", "gene_name": "Vps36", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDRFVWTSGLLEINETLVIQQRGVRVYDGEEKIKFDAGTLLLSTHRLIWRDQKNNECCMAIPLSQIVFIEEQAAGIGKSAKIVVHLHPAPSNKEPGPFQSSKNSYIRLSFKEHGQIEFYRRLSEEMTQRRWETVPVSQSLQTNKGPQPGRVRAVGIVGIERKLEEKRKETDKNISEAFEDLSKLMIKAKEMVELSKSIANKIKEKQGDVTEDETIRFKSYLLSMGIANPVTRETYGSGTQYHMQLAKQLAGILQAPLEERGGIMSLTEVYCLVNRARGMELLSPEDLVNACKMLEALKLPIRLRVFDSGVMVIELQTHKEEEMVASALETVSERGSLTSEEFAKLVGMSVLLAKERLLLAEKMGHLCRDDSVEGLRFYPNLFMTQN", "length": 386 }, "evidence": [ { "id": "F1MT69", "url": "https://omabrowser.org/oma/group/F1MT69/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FF81-1", "protein_name": "Vacuolar protein sorting-associated protein 36", "gene_name": "VPS36", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MASGSSSIAIGGLFENAEVTTSGRPVLRRNEVECFLLSSIDIDSEDDPPRFTALRSGNLILTTHRLIWIPSQSNESVPSSIPLSAVTHIYSHKKSIKSMFHSPRIRFQADPGSIVVTIVFRGKGDFDGFLSKLWECWRGRAWEEEEKSESETSKSGSGTVAQGLYGNDGTVRMVGLAGILRKEQEQWESTDKSLQDAFQDLNALMSKAKEMVSLAEKMRQKLLSAPSSQNGSTDDEEMGSKEEMQQWMLSVGIISPVTKESAGALYHQELSRQLADFVRIPLEKAGGMISLTDMYYHFNRARGTELISPDDLWQACTLWEKFDVPVMLRKFDSGVMVIQNKSHSDEEVMSRIRMLVTKTETLRVGVTASDAALTLKIAPAMAKEHLLSAETKGLLCRDMSPDGLRFYFNLFPEIDPTNLHIVKEFGTYGEWIKATSLLSV", "length": 440 }, "evidence": [ { "id": "F1MT69", "url": "https://omabrowser.org/oma/group/F1MT69/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VU87-1", "protein_name": "Vacuolar protein-sorting-associated protein 36", "gene_name": "Vps36", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNRFAYVEARLSPNESFVSRDNRVKIYDGDQKTDFEDGEVVLTTHRLFWGRPGEIARAAVTLCLPLSYVISVSEETTASNFFGRKTRIIMHLHPPTSDKGPGPLDTSRATHIKLSGKNGLSVEFHSALRETLNARVWEILLTSEIIINGVASSPTLEPANDRLARIQKRTGIGGIERHLEAKAKATDENIALAFQDLSVLMAMAKDMVGVSKTISSKIRKQKGEISDDETVRFKSYLMSLGIDDPVTRDNFTSNSAYFSSLARQICEMLLDPIEEQGGMMSLADVYCRVNRARGLELLSPEDLLHACEQLSGPIRLRSFPSGARVLQLESHDDALIAVDTLEKVEAAESLAVEELAKQLGISLLLAKERLLVAERLGKVCRDESVEGLRFYPNLLLGRD", "length": 399 }, "evidence": [ { "id": "F1MT69", "url": "https://omabrowser.org/oma/group/F1MT69/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "ESCRT II complex", "id": "GO:0000814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000814", "evidence": [ { "database": "UniProtKB", "id": "F1MT69", "url": "https://www.uniprot.org/uniprotkb/F1MT69" } ], "pmid": "" }, { "name": "late endosome membrane", "id": "GO:0031902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031902", "evidence": [ { "database": "UniProtKB", "id": "F1MT69", "url": "https://www.uniprot.org/uniprotkb/F1MT69" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "F1MT69", "url": "https://www.uniprot.org/uniprotkb/F1MT69" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "id": "GO:0043328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043328", "evidence": [ { "database": "UniProtKB", "id": "F1MT69", "url": "https://www.uniprot.org/uniprotkb/F1MT69" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphatidylinositol-3-phosphate binding", "id": "GO:0032266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032266", "evidence": [ { "database": "UniProtKB", "id": "F1MT69", "url": "https://www.uniprot.org/uniprotkb/F1MT69" } ], "pmid": "" }, { "name": "ubiquitin binding", "id": "GO:0043130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "database": "UniProtKB", "id": "F1MT69", "url": "https://www.uniprot.org/uniprotkb/F1MT69" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 14, "end_pos": 16, "annotation": "n_glycosylation_sequon" }, { "start_pos": 173, "end_pos": 175, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MT69-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 386, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MT69-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MT69" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MT69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT69" }, { "id": "PS51495", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51495" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GLUE N-terminal", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 138, "start_aa": "Met", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 14, "end_pos": 16 }, { "start_pos": 173, "end_pos": 175 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMH2-1", "uniprot_ac": "F1MMH2", "uniprot_id": "F1MMH2_BOVIN", "mass": { "chemical_mass": 114375.0, "monoisotopic_mass": 114375.0 }, "refseq": { "ac": "NP_001179647", "name": "integrin alpha-9 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179647" }, "gene_names": [ { "name": "ITGA9", "type": "recommended", "evidence": [ { "id": "F1MMH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMH2" } ] }, { "name": "ITGA9", "type": "synonym", "evidence": [ { "id": "NP_001179647", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179647" } ] } ], "protein_names": [ { "name": "Integrin alpha-9", "type": "recommended", "evidence": [ { "id": "F1MMH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMH2/entry#names_and_taxonomy" } ] }, { "name": "integrin alpha-9 precursor", "type": "synonym", "evidence": [ { "id": "NP_001179647", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179647" } ] }, { "name": "integrin, alpha 9", "type": "synonym", "evidence": [ { "id": "NP_001179647", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179647" } ] } ], "function": [ { "annotation": "Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion. Integrin ITGA9:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction.", "evidence": [ { "database": "UniProtKB", "id": "F1MMH2", "url": "https://www.uniprot.org/uniprotkb/F1MMH2#function" }, { "database": "UniProtKB", "id": "ARBA00055088", "url": "https://www.uniprot.org/uniprotkb/ARBA00055088#function" }, { "database": "UniProtKB", "id": "A0A3Q1N7B8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7B8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMH2", "url": "https://www.uniprot.org/uniprotkb/F1MMH2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ITGA9", "url": "https://www.uniprot.org/uniprotkb/F1MMH2", "locus": { "chromosome": "22", "start_pos": 11270100, "end_pos": 10903850, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016566", "url": "https://www.ensembl.org/id/ENSBTAG00000016566" } ] } } ], "crossref": [ { "id": "F1MMH2", "url": "https://alphafold.ebi.ac.uk/entry/F1MMH2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016566", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016566", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "532127", "url": "https://www.ncbi.nlm.nih.gov/gene/532127", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013517", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013517", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013649", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013649", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018184", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018184", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032695", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032695", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048285", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048285", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048286", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048286", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:532127", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532127", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MMRKGMA", "url": "https://omabrowser.org/oma/group/MMRKGMA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1N7B8", "url": "https://www.orthodb.org/?gene=A0A3Q1N7B8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MMH2", "url": "https://www.orthodb.org/?gene=F1MMH2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23220", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23220", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23220:SF69", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23220:SF69", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01839", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01839", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08441", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08441", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20805", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20805", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20806", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20806", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000178", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179647", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7B8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7B8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N7B8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7B8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMH2", "url": "https://www.uniprot.org/uniprotkb/F1MMH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMH2-1", "url": "https://www.uniprot.org/uniprotkb/F1MMH2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGGSAAQRGAGGLRALLLALVAAGTPAGAYNLDPQRPVRFQGPAGSFFGYAVLEHFHDNTRWVLVGAPKADSKYSTSVKSPGAVFKCRVHTNPDRRCTELDMARGKNRGMPCGKTCREDRDDEWMGVSLARQPKADGRVLACAHRWKNIYYETDHILPHGFCYIIPSNLQAKGRTLIPCYEEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWSGTVKVLNLTDNTYFKLNDEVIMNRRYTYLGYAVTAGHFSHVSSTDVVGGAPQDEGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNTDGLSDLLVGAPMFSEIRDEGQVTVYINKGNGVLEEQLTLSGDGAYNAHFGESIASLGDLDDDGFPDVAIGAPKEDDFSGAVYIYHGDARGMVPQYSMKLSGRKISPVLRMFGQSISGGIDMDGNSYPDMTVGAFMSDSVVLLRARPVITVDVSIFLPASINITAPQCHDGQQPVNCLNVTACFSFHGKHVPGEIGLNYVLTADVAKKEKSQLPRVYLVLLGESVGQVSEKLRLVHLEETCHHYVAHVKRRVQDVISPIVFEAAYSLGEHVTGEEEKELPALTPVLRWKKGQKIAQKNQTVFERNCRSEDCAADLQLQGHLLLSSVDEKTPYLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLELDFLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEVLSFIVTAQSGNVERSESLHNNVLTLTVPLMHEVDTSITGIMSPTSFVYGESVDASNFIQLDDLECHFQPLNVTLQIYNTGPSTLPGSSVSMSFPNRLSPGGAEMFHVQEMVVGQEKGNCSFQKNPTPCIIPQEQENIFHTIFAFFTKSGRKVLDCEKTGISCLTMHCNLSALAKEESRTIDIYMLLNTEILKKDSSSVIQFMTHAKVKVDPSLRVVEVASGNPEEMTVVFEALHNLEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKNRKENEDSWDWVQKNQ", "length": 1035, "header": "tr|F1MMH2-1|F1MMH2_BOVIN Isoform 1 of Integrin alpha-9 OS=Bos taurus OX=9913 GN=ITGA9 PE=3 SV=3 CANONICAL=F1MMH2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N7B8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N7B8/entry", "sequence": { "sequence": "MKLWTVLSMLERLCVCVTADVPAKLRLSVVPSRAPATCVKVCWVLRRSSATRVLVGAPKADSKYSTSVKSPGAVFKCRVHTNPDRRCTELDMARGKNRGMPCGKTCREDRDDEWMGVSLARQPKADGRVLACAHRWKNIYYETDHILPHGFCYIIPSNLQAKGRTLIPCYEEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWSGTVKVLNLTDNTYFKLNDEVIMNRRYTYLGYAVTAGHFSHVSSTDVVGGAPQDEGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNTDGLSDLLVGAPMFSEIRDEGQVTVYINKGNGVLEEQLTLSGDGAYNAHFGESIASLGDLDDDGFPDVAIGAPKEDDFSGAVYIYHGDARGMVPQYSMKLSGRKISPVLRMFGQSISGGIDMDGNSYPDMTVGAFMSDSVVLLRARPVITVDVSIFLPASINITAPQCHDGQQPVNCLNVTACFSFHGKHVPGEIGLNYVLTADVAKKEKSQLPRVYLVLLGESVGQVSEKLRLVHLEETCHHYVAHVKRRVQDVISPIVFEAAYSLGEHVTGEEEKELPALTPVLRWKKGQKIAQKNQTVFERNCRSEDCAADLQLQGHLLLSSVDEKTPYLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLELDFLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEVLSFIVTAQSGNVERSESLHNNVLTLTVPLMHEVDTSITGIMSPTSFVYGESVDASNFIQLDDLECHFQPLNVTLQIYNTGPSTLPGSSVSMSFPNRLSPGGAEMFHVQEMVVGQEKGNCSFQKNPTPCIIPQEQENIFHTIFAFFTKSGRKVLDCEKTGISCLTMHCNLSALAKEESRTIDIYMLLNTEILKKDSSSVIQFMTHAKVKVDPSLRVVEVASGNPEEMTVVFEALHNLEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKNRKENEDSWDWVQKNQ", "length": 1025, "header": "tr|A0A3Q1N7B8-1|F1MMH2_BOVIN Computationally mapped isoform of Integrin alpha-9 OS=Bos taurus OX=9913 GN=ITGA9 PE=3 SV=2 CANONICAL=F1MMH2-1" }, "locus": { "chromosome": "22", "start_pos": 11269693, "end_pos": 10903915, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082966.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082966.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066541.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066541.2" } ] } }, { "isoform_ac": "F1MMH2-1", "url": "https://www.uniprot.org/uniprotkb/F1MMH2/entry", "sequence": { "sequence": "MGGSAAQRGAGGLRALLLALVAAGTPAGAYNLDPQRPVRFQGPAGSFFGYAVLEHFHDNTRWVLVGAPKADSKYSTSVKSPGAVFKCRVHTNPDRRCTELDMARGKNRGMPCGKTCREDRDDEWMGVSLARQPKADGRVLACAHRWKNIYYETDHILPHGFCYIIPSNLQAKGRTLIPCYEEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWSGTVKVLNLTDNTYFKLNDEVIMNRRYTYLGYAVTAGHFSHVSSTDVVGGAPQDEGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNTDGLSDLLVGAPMFSEIRDEGQVTVYINKGNGVLEEQLTLSGDGAYNAHFGESIASLGDLDDDGFPDVAIGAPKEDDFSGAVYIYHGDARGMVPQYSMKLSGRKISPVLRMFGQSISGGIDMDGNSYPDMTVGAFMSDSVVLLRARPVITVDVSIFLPASINITAPQCHDGQQPVNCLNVTACFSFHGKHVPGEIGLNYVLTADVAKKEKSQLPRVYLVLLGESVGQVSEKLRLVHLEETCHHYVAHVKRRVQDVISPIVFEAAYSLGEHVTGEEEKELPALTPVLRWKKGQKIAQKNQTVFERNCRSEDCAADLQLQGHLLLSSVDEKTPYLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLELDFLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEVLSFIVTAQSGNVERSESLHNNVLTLTVPLMHEVDTSITGIMSPTSFVYGESVDASNFIQLDDLECHFQPLNVTLQIYNTGPSTLPGSSVSMSFPNRLSPGGAEMFHVQEMVVGQEKGNCSFQKNPTPCIIPQEQENIFHTIFAFFTKSGRKVLDCEKTGISCLTMHCNLSALAKEESRTIDIYMLLNTEILKKDSSSVIQFMTHAKVKVDPSLRVVEVASGNPEEMTVVFEALHNLEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKNRKENEDSWDWVQKNQ", "length": 1035, "header": "tr|F1MMH2-1|F1MMH2_BOVIN Isoform 1 of Integrin alpha-9 OS=Bos taurus OX=9913 GN=ITGA9 PE=3 SV=3 CANONICAL=F1MMH2-1" }, "locus": { "chromosome": "22", "start_pos": 11269693, "end_pos": 10908546, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022042.8", "url": "https://www.ensembl.org/id/ENSBTAT00000022042.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022042.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022042.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 252, "start_aa": "Thr", "end_pos": 252, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr252", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:532127", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:532127", "resource": "KEGG Pathway" }, { "id": "R-BTA-216083", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-216083", "resource": "Reactome", "description": "Integrin cell surface interactions" }, { "id": "R-BTA-3000178", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000178", "resource": "Reactome", "description": "ECM proteoglycans" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QII8-1", "protein_name": "Integrin subunit alpha 9", "gene_name": "ITGA9", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARGKNRGMSCGKTCREDRDDEWMGVSLARQPKADGQVLACAHRWKNIYYETDHILPHGFCYIIPSNLQAKGRTLIPCYEEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWAGTVKVLNLTDNTYFKLNDEVIMNRRYTYLGYAVTAGHFSHVSTTDVVGGAPQDDGIGKVYVFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNADGLSDLLVGAPMFSEIRDEGQVTVYINRGNGALEEQLALTGDGAYNAHFGESIASLGDLDDDGFPDVAIGAPKEDDFSGAVYIYHGDAGGMVPQYSMKLSGRKISPVLRMFGQSISGGVDMDGNGYPDVTIGAFMSDSVVLLRARPVITVDVTILLPASINITAPQCHDGQQPVNCLNVTVCFSFHGKHVPGEIGLNYVLTADVAKKEKSQLPRVYFVLLGESVGQVSEKLQLVHLEETCHHYVAHVKRRVQDVISPIVFEAAYSLGEHVTGEEEKELPALTPVLRWKKGQKIAQKNQTVFERNCRSEDCAADLQLQGHLLLSSIDEKTPYLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEVLSFIVTAQSGNVERSESLHDNTLMLTVPLMHEVDTSITGITSPTSFVYGESVEASNFIQLDDLECHFQPLNVTLQVYNTGPSTLPGSSVSISFPNRLSPGGAEIFHVQEMVVGQEKGNCSFQKNPTPCIIPQEQENIFHTIFAFFTKSGRKVLDCEKPGISCLTLHCNLSALTKEESRTIDIYMLLNTEILKKDSSSVIQFMTRAKVKVDPAQRVVEMASGNPEEMTVVFEALHNLEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKNRKENEDSWDWVQKNQ", "length": 934 }, "evidence": [ { "id": "F1MMH2", "url": "https://omabrowser.org/oma/group/F1MMH2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z2J6-1", "protein_name": "Integrin alpha-9", "gene_name": "ITGA9", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPAGRRCWARVLSALLWVALACCYNVDVGRPVVFQGPNGSFFGYSVLQHYHDSTRWVLVGAPKADSRYSTSIQSPGAVFKCRVHTNPDRRCTELDMGRGNSRGMLCGKTCKEDRDDEWMGVSLARQPKAGGSVLACAHRWKNIYYETEYILPHGFCNIIPPNLQPSGKKLLPCYEEYKKKYGEEHGSCQAGIAGFFTEELVIMGAPGSYYWTGTVKVLNLTDNTYYKLNDDAVIARRYTYLGYAVTAGHFSQPTTTDVVGGAPQDGGIGKVYIFRTDRRSGSLVKIFQASGKKMGSYFGSSLCAVDLNSDGLSDLLVGAPMFSEIRDEGQVTVYINRGNGVLEEQLVLDGDGAYNAHFGESIAALGDIDDDGFPDVAIGAPKEDNYIGAVYIYHGDANGIVPQYSMKLSGQTINPMLRMFGQSISGGVDMDGNGYPDMTVGAFLSDHVVLLRSRPVITMDISIFLPASINITAPQCHDSLQPVNCLNVTACFRFSGKHVPGEIGLNYNLTADVAKKEKSQQPRVYFVTSGETVGQITEKLELSYMQEKCRHFLAYVKRRVKDVISPIVFEASYSLGEHVIERGKEDKELPSLKPVLRWKKGQKIAQRNQTVFERNCQSDDCAADLKLQGKLLLSSVDDRTAYLALGAVRNISLNISISNIGDDAYDTNVFFNFSGELFFIKMWQKEEQGISCELLESDFLKCSVEFPFMRSKSRYEFSVIFDTSHLSGQEETLTFLVTAQSGNMERMESLHDNTLTLSVPLMHEVDSIVLDVFQTYLHSQLWLYKYFLLMSSHVCLGLLNTSICIFFLQVYNAGPSTLPGAFLDISFPNRLSATGAEIFHVQQMMVGQDKGNCSFHRNRNPCVVPQENENIFHTIFAFFTKSGRKVLDCERPGRSCLIIRCNLSSLAKAESSEISIYTLLNTEILKKDISSVIQFVTRARVQVDPDLRVVEVPNGSPEEKTVVFEALHNLEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKNRKETEDSWDWVQKNQ", "length": 1033 }, "evidence": [ { "id": "F1MMH2", "url": "https://omabrowser.org/oma/group/F1MMH2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B8JK39-1", "protein_name": "Integrin alpha-9", "gene_name": "Itga9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGGPAAARTGAGGLRALLLALVAAGVPAGAYNLDAQRPVRFQGPSGSFFGYAVLEHFHDNTRWVLVGAPKADSKYSTSVKSPGAVFKCRVHTNPDRRCTELDMARGRTRGAPCGKTCRGDRDDEWMGVSLARQPRADGRVLACAHRWKNIYYEADHILPHGFCYLIPSNLQAKGKVLIPCYEEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYWAGTLKVLNLTDNTYFKLNDEAIMNRRYTYLGYAVTAGHFSHPSITDVVGGAPQDEGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNMDGLSDLLVGAPMFSEIRDEGQVTVYLNQGHGALEEQLTLTGDAAYNAHFGESIANLGDIDDDGFPDVAVGAPKEEDFAGAVYIYHGDANGIVPKYSMKLSGRRLNPTLRMFGQSISGGIDMDGNGYPDVTIGAFLSDSVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVTVCFRFHGKNVPGEIGLNYNLTADVAQKEKGQLPRVYFVLFGETAGQVSERLQLSHMDEVCHHYVAHVKRRVQDVISPIVFEAAYSLDEHVMGEEDRELPDLTPVLRWKKGQRISQKNQTVFERNCQSEDCAADLQLRGKLLLSSVDEKTPHLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEILSFIVTAQSGNLERSEALHDNTLTLTVPLVHEVDTSITGIVSPTSFVYGESVDASNFIQLDDQECHFQPVNITLQVYNMGPSTLPGSSVSISFPSRLSPGGAEMFQVQDMVVSQEKGNCSLQRNPTPCIIPQEQENIFHTIFAFFSKSGRKVLDCEKPGSFCLTLHCNLSALPKEESRTINLYMLLNTEILKKDSSSVIQFMARAKVKVEPALRVVEIANGNPEETLVVFEALHNLEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKNRKENEDGWDWVQKNQ", "length": 1036 }, "evidence": [ { "id": "F1MMH2", "url": "https://omabrowser.org/oma/group/F1MMH2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "D3ZN51-1", "protein_name": "Integrin alpha-9", "gene_name": "Itga9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWFIQVQHQVQAVLREPRPAGGAAGPSRQGRPGRPPLGRASPQSSAARAPDPLHRRAQSSRRGSRGRGALAASPGLFPARAAALPSVPGSDLECTARAPGSVVSREPRSRGRAQGGGRLGMGGPAAKGTGAGGLRALLLALVAAGVPAGAYNIDAQRPVRFQGPPGSFFGYAVLEHFHDNTRWVLVGAPKADSKYSTSVKSPGAVFKCRVHTNPDRRCTELDMARERNRGESCGKTCRGDRDDEWMGVSLARQPKADGRVLACAHRWKNIYYETDHILPHGFCYLIPSNLQAKGRMLIPCYEEYKKKYGEEHGSCQAGIAGFFTEELVIMGAPGSFYWAGTLKVLNLTDNTYFKLNDDAIMNRRYTYLGYAVTAGHFSHPSVTDVVGGAPQDEGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNMDGLSDLLVGAPMFSEIRDEGQVTVYLNQGHGVLEEQLTLTGDAAYNAHFGESIASLGDLDDDGFPDVAVGAPMEDDFAGTVYIYHGDAQGIVPQYSMKLSGRKINPILQMFGQSISGGIDMDGNGYPDVTVGAFLSDSVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVTVCFRFHGKNVPGEIGLNYNLTADVAQKEKGQLPRVYFVLLGETAGQVSERLQLTHMDEVCHHYVAHVKRRVQDVISPIVFEAAYSLGEHVIGEEDRELPDLTPVLRWKKGQRIAQKNQTVFERNCRSEDCAADLQLRGKLLLSSVDEKTTHLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEILSFIVTAQSGNMERSEALHDNTLTLTIPLVHEVDTSITGIVSPTSFVYGESVDASNFIQLDDQECHFQPVNITLQVYNMGPSTLPGSSVSISFPSRLSPGGAEMFQVQDMVVSQEKGNCSLQRNPTPCIIPQEQENIFHTIFAFFSKSGRKVLDCEKTGSFCLTLHCNLSALPKEESRAIDLYMLLNTEILKKDSSSVIQFMARAKVKVEPALRVVEIANGNPEETLVVFEALHNLEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKNRKENEEAWDWVQKNQ", "length": 1156 }, "evidence": [ { "id": "F1MMH2", "url": "https://omabrowser.org/oma/group/F1MMH2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1Q8T4-1", "protein_name": "Integrin alpha-9", "gene_name": "itga9", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": 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"length": 1032 }, "evidence": [ { "id": "F1MMH2", "url": "https://omabrowser.org/oma/group/F1MMH2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q13797-1", "protein_name": "Integrin alpha-9", "gene_name": "ITGA9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"length": 1035 }, "evidence": [ { "id": "F1MMH2", "url": "https://omabrowser.org/oma/group/F1MMH2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1MMH2", "url": "https://www.uniprot.org/uniprotkb/F1MMH2" } ], "pmid": "" }, { "name": "integrin-mediated signaling pathway", "id": "GO:0007229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "evidence": [ { "database": "UniProtKB", "id": "F1MMH2", "url": "https://www.uniprot.org/uniprotkb/F1MMH2" } ], "pmid": "" }, { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "F1MMH2", "url": "https://www.uniprot.org/uniprotkb/F1MMH2" } ], "pmid": "" }, { "name": "negative regulation of vasoconstriction", "id": "GO:0045906", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045906", "evidence": [ { "database": "UniProtKB", "id": "F1MMH2", "url": "https://www.uniprot.org/uniprotkb/F1MMH2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MMH2", "url": "https://www.uniprot.org/uniprotkb/F1MMH2" } ], "pmid": "" }, { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "F1MMH2", "url": "https://www.uniprot.org/uniprotkb/F1MMH2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "integrin alpha9-beta1 complex", "id": "GO:0034679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034679", "evidence": [ { "database": "UniProtKB", "id": "F1MMH2", "url": "https://www.uniprot.org/uniprotkb/F1MMH2" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "F1MMH2", "url": "https://www.uniprot.org/uniprotkb/F1MMH2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 476, "end_pos": 478, "annotation": "n_glycosylation_sequon" }, { "start_pos": 493, "end_pos": 495, "annotation": "n_glycosylation_sequon" }, { "start_pos": 612, "end_pos": 614, "annotation": "n_glycosylation_sequon" }, { "start_pos": 654, "end_pos": 656, "annotation": "n_glycosylation_sequon" }, { "start_pos": 658, "end_pos": 660, "annotation": "n_glycosylation_sequon" }, { "start_pos": 672, "end_pos": 674, "annotation": "n_glycosylation_sequon" }, { "start_pos": 676, "end_pos": 678, "annotation": "n_glycosylation_sequon" }, { "start_pos": 807, "end_pos": 809, "annotation": "n_glycosylation_sequon" }, { "start_pos": 854, "end_pos": 856, "annotation": "n_glycosylation_sequon" }, { "start_pos": 904, "end_pos": 906, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MMH2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1035, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MMH2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MMH2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MMH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMH2" }, { "id": "PF08441", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08441" } ], "ann_type": "Domain_Extent_Annotation", 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772, "end_pos": 965, "start_aa": "Ser", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 252 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 225, "end_pos": 227 }, { "start_pos": 476, "end_pos": 478 }, { "start_pos": 493, "end_pos": 495 }, { "start_pos": 612, "end_pos": 614 }, { "start_pos": 654, "end_pos": 656 }, { "start_pos": 658, "end_pos": 660 }, { "start_pos": 672, "end_pos": 674 }, { "start_pos": 676, "end_pos": 678 }, { "start_pos": 807, "end_pos": 809 }, { "start_pos": 854, "end_pos": 856 }, { "start_pos": 904, "end_pos": 906 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MPK4-1", "uniprot_ac": "F1MPK4", "uniprot_id": "F1MPK4_BOVIN", "mass": { "chemical_mass": 43478.0, "monoisotopic_mass": 43478.0 }, "refseq": { "ac": "XP_024835466", "name": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835466" }, "gene_names": [ { "name": "HIBCH", "type": "recommended", "evidence": [ { "id": "F1MPK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPK4" } ] }, { "name": "HIBCH", "type": "synonym", "evidence": [ { "id": "XP_024835466", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835466" } ] } ], "protein_names": [ { "name": "3-hydroxyisobutyryl-CoA hydrolase", "type": "recommended", "evidence": [ { "id": "F1MPK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPK4/entry#names_and_taxonomy" } ] }, { "name": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024835466", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835466" } ] }, { "name": "3-hydroxyisobutyryl-coenzyme A hydrolase", "type": "synonym", "evidence": [ { "id": "F1MPK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPK4/entry#names_and_taxonomy" } ] }, { "name": "3.1.2.4", "type": "synonym", "evidence": [ { "id": "F1MPK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPK4/entry#names_and_taxonomy" } ] }, { "name": "HIB-CoA hydrolase", "type": "synonym", "evidence": [ { "id": "F1MPK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPK4/entry#names_and_taxonomy" } ] }, { "name": "HIBYL-CoA-H", "type": "synonym", "evidence": [ { "id": "F1MPK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPK4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NAY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAY9#function" }, { "database": "UniProtKB", "id": "ARBA00024871", "url": "https://www.uniprot.org/uniprotkb/ARBA00024871#function" }, { "database": "UniProtKB", "id": "A0AAA9S393", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S393#function" }, { "database": "UniProtKB", "id": "A0AAA9SJC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC8#function" }, { "database": "UniProtKB", "id": "A0AAA9T026", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T026#function" }, { "database": "UniProtKB", "id": "A0A3Q1MBY6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBY6#function" }, { "database": "UniProtKB", "id": "A0A3Q1MDG7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDG7#function" }, { "database": "UniProtKB", "id": "A0A3Q1LRZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRZ2#function" }, { "database": "UniProtKB", "id": "A0A3Q1LT48", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT48#function" }, { "database": "UniProtKB", "id": "A0A3Q1LUU2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUU2#function" }, { "database": "UniProtKB", "id": "F1MPK4", "url": "https://www.uniprot.org/uniprotkb/F1MPK4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MPK4", "url": "https://www.uniprot.org/uniprotkb/F1MPK4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HIBCH", "url": "https://www.uniprot.org/uniprotkb/F1MPK4", "locus": { "chromosome": "2", "start_pos": 6129228, "end_pos": 5980895, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007787", "url": "https://www.ensembl.org/id/ENSBTAG00000007787" } ] } } ], "crossref": [ { "id": "F1MPK4", "url": "https://alphafold.ebi.ac.uk/entry/F1MPK4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007787", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007787", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06558", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06558", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535883", "url": "https://www.ncbi.nlm.nih.gov/gene/535883", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032259", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032259", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045004", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045004", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:535883", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535883", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EVFTMEY", "url": "https://omabrowser.org/oma/group/EVFTMEY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LRZ2", "url": "https://www.orthodb.org/?gene=A0A3Q1LRZ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LT48", "url": "https://www.orthodb.org/?gene=A0A3Q1LT48", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUU2", "url": "https://www.orthodb.org/?gene=A0A3Q1LUU2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBY6", "url": "https://www.orthodb.org/?gene=A0A3Q1MBY6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MDG7", "url": "https://www.orthodb.org/?gene=A0A3Q1MDG7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NAY9", "url": "https://www.orthodb.org/?gene=A0A3Q1NAY9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MPK4", "url": "https://www.orthodb.org/?gene=F1MPK4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43176", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43176", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43176:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43176:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16113", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16113", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-70895", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70895", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024835466", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835466", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "20888", "url": "https://www.rhea-db.org/rhea/20888", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LRZ2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LT48", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT48", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LT48-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT48-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUU2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUU2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUU2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBY6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBY6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBY6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDG7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MDG7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NAY9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NAY9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S393", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S393", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S393-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S393-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJC8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T026", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T026", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T026-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T026-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPK4", "url": "https://www.uniprot.org/uniprotkb/F1MPK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPK4-1", "url": "https://www.uniprot.org/uniprotkb/F1MPK4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLQRLCRLMSRFNSYKRTNIILQHLKMSNHTDAAAEVLLERKGCAGVITLNRPRFLNTLTLGMIRQIYAQLKKWEQDPKTFLIIIKGAGEKAFCAGGDIRALSEARNTNQKMLQDLFREEYILNNAIDSCQKPYIALIHGITMGGGVGVSVHGQFRVATEKSVFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYTAGIATHFVDFEKLGMLEEDLLALKSPSKENIADVLETYHAKSKTDQDKPFILEEHMDKINSWFSTNTVEQIVDNLQQDGSSFALEQLKVIKKMSPTSLKITLRQLMEGSSKTLPEVLIMEYRLSQACMKGHDFHEGVRAVLIDKDQSPKWKPADLKEVTDEDLNDYFKSLGSNDLKF", "length": 386, "header": "tr|F1MPK4-1|F1MPK4_BOVIN Isoform 1 of 3-hydroxyisobutyryl-CoA hydrolase OS=Bos taurus OX=9913 GN=HIBCH PE=3 SV=3 CANONICAL=F1MPK4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRZ2/entry", "sequence": { "sequence": "MGLQRLCRLMSRFNSYKRTNIILQHLKMSNHTDAAAEVLLERKGCAGVITLNRPRFLNTLTLGMIRQIYAQLKKWEQDPKTFLIIIKGAGEKAFCAGGDIRDSCQKPYIALIHGITMGGGVGVSVHGQFRVATEKSVFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYTAGIATHFVDFEKLGMLEEDLLALKSPSKENIADVLETYHAKSKTDQDKPFILEEHMDKINSWFSTNTVEQIVDNLQQDGSSFALEQLKVIKKMSPTSLKITLRQLMEGSSKTLPEVLIMEYRLSQACMKGHDFHEGVRAVLIDKDQSPKWKPADLKEVTDEDLNDYFKSLGSNDLKF", "length": 359, "header": "tr|A0A3Q1LRZ2-1|F1MPK4_BOVIN Computationally mapped isoform of 3-hydroxyisobutyryl-CoA hydrolase OS=Bos taurus OX=9913 GN=HIBCH PE=3 SV=1 CANONICAL=F1MPK4-1" }, "locus": { "chromosome": "2", "start_pos": 6094835, "end_pos": 5980954, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077729.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077729.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063065.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063065.1" } ] } }, { "isoform_ac": "A0A3Q1LT48-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LT48/entry", "sequence": { "sequence": "MGLQRLCRLMSRFNSYKRTNIILQHLKMSNHTDAAAEVLLERKGCAGVITLNRPRFLNTLTLGMIRQIYAQLKKWEQDPKTFLIIIKGAGEKAFCAGGDIRALSEARNTNQKMLQDLFREEYILNNAIDSCQKPYIALIHGITMGGGVGVSVHGQFRVATEKSVFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYTAGIATHFVDFEKLGMLEEDLLALKSPSKENIADVLETYHAKSKTDQDKPFILEEHMDKINSWFSTNTVEQIVDNLQQDGSSFALEQLKVIKKMSPTSLKITLRQLMEGSSKTLPEVLIMEYRLSQACMKGHDFHEGVRAALRSLLFFCPALVKPRPW", "length": 366, "header": "tr|A0A3Q1LT48-1|F1MPK4_BOVIN Computationally mapped isoform of 3-hydroxyisobutyryl-CoA hydrolase OS=Bos taurus OX=9913 GN=HIBCH PE=3 SV=3 CANONICAL=F1MPK4-1" }, "locus": { "chromosome": "2", "start_pos": 6091936, "end_pos": 5980954, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000084409.3", "url": "https://www.ensembl.org/id/ENSBTAT00000084409.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060481.3", "url": "https://www.ensembl.org/id/ENSBTAP00000060481.3" } ] } }, { "isoform_ac": "A0A3Q1LUU2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUU2/entry", "sequence": { "sequence": "LQRRHYSLFTQKMSNHTDAAAEVLLERKGCAGVITLNRPRFLNTLTLGMIRQIYAQLKKWEQDPKTFLIIIKGAGEKAFCAGGDIRALSEARNTNQKMLQDLFREEYILNNAIDSCQKPYIALIHGITMGGGVGVSVHGQFRVATEKSVFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYTAGIATHFVDFEKLGMLEEDLLALKSPSKENIADVLETYHAKSKTDQDKPFILEEHMDKINSWFSTNTVEQIVDNLQQDGSSFALEQLKVIKKMSPTSLKITLRQLMEGSSKTLPEVLIMEYRLSQACMKGHDFHEGVRAVLIDKDQSPKWKPADLKEVTDEDLNDYFKSLGSNDLKF", "length": 371, "header": "tr|A0A3Q1LUU2-1|F1MPK4_BOVIN Computationally mapped isoform of 3-hydroxyisobutyryl-CoA hydrolase OS=Bos taurus OX=9913 GN=HIBCH PE=3 SV=2 CANONICAL=F1MPK4-1" }, "locus": { "chromosome": "2", "start_pos": 6094835, "end_pos": 6007858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071304.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071304.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061130.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061130.2" } ] } }, { "isoform_ac": "A0A3Q1MBY6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBY6/entry", "sequence": { "sequence": "MGLQRLCRLMSRFNSYKRTNIILQHLKMSNHTDAAAEVLLERKGCAGVITLNRPRFLNTLTLGMIRQIYAQLKKWEQDPKTFLIIIKGAGEKAFCAGGDIRALSEARNTNQKMLQDLFREEYILNNAIDSCQKPYIALIHGITMGGGVGVSVHGQFRVATEKSVFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYTAGIATHFVDFEKLGMLEEDLLALKSPSKENIADVLETYHAKSKTDQDKPFILEEHMDKINSWFSTNTVEQIVDNLQQDGSSFALEQLKVIKKMSPTSLKITLRQLMEGSSKTLPEVLIMEYRLSQACMKGHDFHEGVRAAHQAPLPMGFSRQEHCSSLEDLTSFK", "length": 374, "header": "tr|A0A3Q1MBY6-1|F1MPK4_BOVIN Computationally mapped isoform of 3-hydroxyisobutyryl-CoA hydrolase OS=Bos taurus OX=9913 GN=HIBCH PE=3 SV=2 CANONICAL=F1MPK4-1" }, "locus": { "chromosome": "2", "start_pos": 6123152, "end_pos": 5980954, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083322.3", "url": "https://www.ensembl.org/id/ENSBTAT00000083322.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071596.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071596.2" } ] } }, { "isoform_ac": "A0A3Q1MDG7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MDG7/entry", "sequence": { "sequence": "MGLQRLCRLMSRFNSYKRTNIILQHLKMSNHTDAAAEVLLERKGCAGVITLNRPRFLNTLTLGMIRQIYAQLKKWEQDPKTFLIIIKGAGEKAFCAGGDIRALSEARNTNQKMLQDLFREEYILNNAIDSCQKPYIALIHGITMGGGVGVSVHGQFRVATEKSVFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYTAGIATHFVDFEKLGMLEEDLLALKSPSKENIADVLETYHAKSKTDQDKPFILEEHMDKINSWFSTNTVEQIVDNLQQDGSSFALEQLKVIKKMSPTSLKITLRQLMEGSSKTLPEVLIMEYRLSQACMMRKQWHRRVTCLR", "length": 350, "header": "tr|A0A3Q1MDG7-1|F1MPK4_BOVIN Computationally mapped isoform of 3-hydroxyisobutyryl-CoA hydrolase OS=Bos taurus OX=9913 GN=HIBCH PE=3 SV=2 CANONICAL=F1MPK4-1" }, "locus": { "chromosome": "2", "start_pos": 6087864, "end_pos": 5980954, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079509.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079509.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072190.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072190.2" } ] } }, { "isoform_ac": "A0A3Q1NAY9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NAY9/entry", "sequence": { "sequence": "MGLQRLCRLMSRFNSYKRTNIILQHLKMSNHTDAAAEVLLERKGCAGVITLNRPRFLNTLTLGMIRQIYAQLKKWEQDPKTFLIIIKGAGEKAFCAGGDIRALSEARNTNQKMLQDLFREEYILNNAIDSCQKPYIALIHGITMGGGVGVSVHGQFRVATEKSVFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYTAGIATHFVDFEKLGMLEEDLLALKSPSKENIADVLETYHAKSKTDQDKPFILEEHMDKINSWFSTNTVEQIVDNLQQDGSSFALEQLKVIKKMSPTSLKITLRQLMEGSSKTLPEVLIMEYRLSQACMKGHDFHEGVRAGILLYDSAFLSHFMTC", "length": 364, "header": "tr|A0A3Q1NAY9-1|F1MPK4_BOVIN Computationally mapped isoform of 3-hydroxyisobutyryl-CoA hydrolase OS=Bos taurus OX=9913 GN=HIBCH PE=3 SV=2 CANONICAL=F1MPK4-1" }, "locus": { "chromosome": "2", "start_pos": 6129155, "end_pos": 5980954, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081187.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081187.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068434.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068434.2" } ] } }, { "isoform_ac": "A0AAA9S393-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S393/entry", "sequence": { "sequence": "MGLQRLCRLMSRFNSYKRTNIILQHLKMSNHTDAAAEVLLERKGCAGVITLNRPRFLNTLTLGMIRQIYAQLKKWEQDPKTFLIIIKGAGEKAFCAGGDIRALSEARNTNQKMLQDLFREEYILNNAIDSCQKPYIALIHGITMGGGVGVSVHGQFRVATEKSVFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYTAGIATHFVDFEKLGMLEEDLLALKSPSKENIADVLETYHAKSKTDQDKPFILEEHMDKINSWFSTNTVEQIVDNLQQDGSSFALEQLKVIKKMSPTSLKITLRQLMEGSSKTLPEVLIMEYRLSQACMKGHDFHEGVRAARTWKQPRCPSADEWIRKLWYIYTMEYYSAIKKNTFESVLMRWMKLEPIIQSEVSQKEKHQCSILTHIYGL", "length": 419, "header": "tr|A0AAA9S393-1|F1MPK4_BOVIN Computationally mapped isoform of 3-hydroxyisobutyryl-CoA hydrolase OS=Bos taurus OX=9913 GN=HIBCH PE=3 SV=1 CANONICAL=F1MPK4-1" }, "locus": { "chromosome": "2", "start_pos": 6124047, "end_pos": 5980954, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124838.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124838.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080396.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080396.1" } ] } }, { "isoform_ac": "A0AAA9SJC8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC8/entry", "sequence": { "sequence": "MGLQRLCRLMSRFNSYKRTNIILQHLKMSNHTDAAAEVLLERKGCAGVITLNRPRFLNTLTLGMIRQIYAQLKKWEQDPKTFLIIIKGAGEKAFCAGGDIRALSEARNTNQKMLQDLFREEYILNNAIDSCQKPYIALIHGITMGGGVGVSVHGQFRVATEKSVFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYTAGIATHFVDFEKLGMLEEDLLALKSPSKENIADVLETYHAKSKTDQDKPFILEEHMDKINSWFSTNTVEQIVDNLQQDGSSFALEQLKVIKKMSPTSLKITLRQLMEGSSKTLPEVLIMEYRLSQACMKGHDFHEGVRADTKTTR", "length": 354, "header": "tr|A0AAA9SJC8-1|F1MPK4_BOVIN Computationally mapped isoform of 3-hydroxyisobutyryl-CoA hydrolase OS=Bos taurus OX=9913 GN=HIBCH PE=3 SV=1 CANONICAL=F1MPK4-1" }, "locus": { "chromosome": "2", "start_pos": 6104770, "end_pos": 5980954, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121045.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121045.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083913.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083913.1" } ] } }, { "isoform_ac": "A0AAA9T026-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T026/entry", "sequence": { "sequence": "MGLQRLCRLMSRFNSYKRTNIILQHLKMSNHTDAAAEVLLERKGCAGVITLNRPRFLNTLTLGMIRQIYAQLKKWEQDPKTFLIIIKGAGEKAFCAGGDIRALSEARNTNQKMLQDLFREEYILNNAIDSCQKPYIALIHGITMGGGVGVSVHGQFRVATEKSVFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYTAGIATHFVDFEKLGMLEEDLLALKSPSKENIADVLETYHAKSKTDQDKPFILEEHMDKINSWFSTNTVEQIVDNLQQDGSSFALEQLKVIKKMSPTSLKITLRQLMEGSSKTLPEVLIMEYRLSQACMDTSEINIHFHQSSHVVFYLSREDTKTTR", "length": 365, "header": "tr|A0AAA9T026-1|F1MPK4_BOVIN Computationally mapped isoform of 3-hydroxyisobutyryl-CoA hydrolase OS=Bos taurus OX=9913 GN=HIBCH PE=3 SV=1 CANONICAL=F1MPK4-1" }, "locus": { "chromosome": "2", "start_pos": 6104770, "end_pos": 5980954, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110292.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110292.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088998.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088998.1" } ] } }, { "isoform_ac": "F1MPK4-1", "url": "https://www.uniprot.org/uniprotkb/F1MPK4/entry", "sequence": { "sequence": "MGLQRLCRLMSRFNSYKRTNIILQHLKMSNHTDAAAEVLLERKGCAGVITLNRPRFLNTLTLGMIRQIYAQLKKWEQDPKTFLIIIKGAGEKAFCAGGDIRALSEARNTNQKMLQDLFREEYILNNAIDSCQKPYIALIHGITMGGGVGVSVHGQFRVATEKSVFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYTAGIATHFVDFEKLGMLEEDLLALKSPSKENIADVLETYHAKSKTDQDKPFILEEHMDKINSWFSTNTVEQIVDNLQQDGSSFALEQLKVIKKMSPTSLKITLRQLMEGSSKTLPEVLIMEYRLSQACMKGHDFHEGVRAVLIDKDQSPKWKPADLKEVTDEDLNDYFKSLGSNDLKF", "length": 386, "header": "tr|F1MPK4-1|F1MPK4_BOVIN Isoform 1 of 3-hydroxyisobutyryl-CoA hydrolase OS=Bos taurus OX=9913 GN=HIBCH PE=3 SV=3 CANONICAL=F1MPK4-1" }, "locus": { "chromosome": "2", "start_pos": 6094835, "end_pos": 5980954, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010242.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010242.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010242.5", "url": "https://www.ensembl.org/id/ENSBTAP00000010242.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:535883", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:535883", "resource": "KEGG Pathway" }, { "id": "R-BTA-70895", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70895", "resource": "Reactome", "description": "Branched-chain amino acid catabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QLF4-1", "protein_name": "3-hydroxyisobutyryl-CoA hydrolase", "gene_name": "HIBCH", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGLWKVWSFTSRFNSSKRTNTILQHLTMSKHTDAAAEVLLERKGCAGVITLNRPKFLNALNLSMIQQIYPQLKKWEQDPETFLIIMKGAGEKAFCAGGDIRVISENTKTNPKMVQDFFREEYMLNNAIDSCLKPYIALIHGITMGGGVGLSVHGQFRVATEKSLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYTAGIATHFVDSEKLGMLEDDLLALNSPSKENIADVLETYHTKSKIDQDKSFILEEHMDKINSWFSANTVEEIIENLQQDGSSFALEQLKVINKMSPTSLKITLRQLMEGSSKTLPEVLTMEYRLSQACIGGHDFHEGVRAVLIDKDQNPKWKPANLKEVTDEDLNNHFNSLGSNDLKF", "length": 386 }, "evidence": [ { "id": "F1MPK4", "url": "https://omabrowser.org/oma/group/F1MPK4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q55GS6-1", "protein_name": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "gene_name": "hibch", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDRLLTISNHIGKNIRQFSTSTEEVLFEKKGKCLKVLLNRPKALNALNPNMVKILTPKYLEMKTKKDGEGVIVMKGAGEKAFCAGGDIRAIYDYKQLNEEQKSKTNDIGDLFFREEYILNNLIGTNPIAQVSIYNGFAMGGGIGLSVHGKFRVATENTVFAMPETGIGFFCDVGGSYFLPRLPNNYGMYLALTGSKLKGNNVYLAGVATHFVSNEHIQALEKEIEECENPTSQTINSILTKYHDKSKSTSNEYNDNLGDIERIFGKNSVKEIFEQLELLENSEWAKQTLKTLKSVSPSSLMVVFEQMKQGAKLPSLAKCLEMEFRISQHFLEKPDFFEGVRALLVDKDKNPKWLPPSIDQIDQTLVNSYFKPLSNNKELKF", "length": 381 }, "evidence": [ { "id": "F1MPK4", "url": "https://omabrowser.org/oma/group/F1MPK4/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5XIE6-1", "protein_name": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "gene_name": "Hibch", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGQQFVWRLQSRFSSIRRASVILQHLRMSKHTETAEVLLERRGCAGVITLNRPKLLNALSLNMIRQIYPQLKKWERDPDTFLIIIKGAGGKAFCAGGDIKALSEAKKAGQTLSQDLFREEYILNNAIASCQKPYVALIDGITMGGGVGLSVHGQFRVATERSLFAMPETGIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVHRAGIATHFVDSEKLHVLEEELLALKSPSAEDVAGVLESYHAKSKMGQDKSIIFEEHMDKINSCFSANTVEQILENLRQDGSPFAMEQIKVINKMSPTSLKITLRQLMEGSTKTLQEVLTMEYRLTQACMEGHDFHEGVRAVLIDKDQTPKWKPADLKDVTDEDLNSYFKSLGSRDLKF", "length": 385 }, "evidence": [ { "id": "F1MPK4", "url": "https://omabrowser.org/oma/group/F1MPK4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5ZJ60-1", "protein_name": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "gene_name": "HIBCH", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAARVLMAPRRLKPFNRLQVILQHLKTCKHTDSAADVLLQKQGGAGIITLNRPKVLNALSFKMIQQIYPQIKAWEQDPETFLIIIKGTGEKAFCAGGDVRAIADAGKAGDTMTRDYFREEYRLDNAIGTCKKPYVALIDGITMGGGVGLSVHGHFRVATEKTVFAMPETAIGLFPDVGGGYFLPRLSGKIGHLLALTGFRLKGRDVLKAGIATHFVESGKLPELEKDLIALKSPSKENIADLLNSYHMQTKIDQEKEFVLDEHMERINSIFSANSMEEIVQKLKQDGSPFATKQLEAINKMSPTSLKLTLRQLREGATMSLQDVFTMEYRLSQACMRGHDFYEGVRAVLIDKDQSPRWKPAALEEVSDEFVDNCFKPLGNNDLKL", "length": 385 }, "evidence": [ { "id": "F1MPK4", "url": "https://omabrowser.org/oma/group/F1MPK4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6NVY1-1", "protein_name": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "gene_name": "HIBCH", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGQREMWRLMSRFNAFKRTNTILHHLRMSKHTDAAEEVLLEKKGCTGVITLNRPKFLNALTLNMIRQIYPQLKKWEQDPETFLIIIKGAGGKAFCAGGDIRVISEAEKAKQKIAPVFFREEYMLNNAVGSCQKPYVALIHGITMGGGVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLEEDLLALKSPSKENIASVLENYHTESKIDRDKSFILEEHMDKINSCFSANTVEEIIENLQQDGSSFALEQLKVINKMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFKSLGSSDLKF", "length": 386 }, "evidence": [ { "id": "F1MPK4", "url": "https://omabrowser.org/oma/group/F1MPK4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q86BP1-1", "protein_name": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "gene_name": "Hibch", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQGPIQRLVYTFGHRTCSQLPMIGGATISQTKPTTMALSVRQSSSSVLATESSNKGMIILNRPKALNAINLEMVRKIYKHLKKCEKSKSLVIIKGTGDKAFCAGGDVRALVEAGPTDESKSFFREEYSTNALIGNYKIPYIAIIDGITMGGGVGLSVHGKYRVASDRTLFAMPETAIGLFPDVGGSYFLPRLQGKLGLYLGLTGYRLRGADVYYSGIATHYCESSKIPDLETALLNCPDADDVPELLQKYHSPPEKPFSLQPVLEQINKNFSADSVEGILENLQNDGSEWAKKTLETLSKMSPTSMKVTFRQLELGSQLSLAQCLIMEYRLAVRHLERSDFKEGVRALLIDKDQKPQWQPTKLADVTEEHVQWFFRKLPDTEELKL", "length": 386 }, "evidence": [ { "id": "F1MPK4", "url": "https://omabrowser.org/oma/group/F1MPK4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8QZS1-1", "protein_name": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "gene_name": "Hibch", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGQPYAWRLLSRVSSFRRASVILQHLRMSMHTEAAEVLLERRGCGGVITLNRPKFLNALSLNMIRQIYPQLKTWEQDPDTFLIIIKGAGGKAFCAGGDIKALSEAKKARQNLTQDLFREEYILNNAIASCQKPYVALIDGITMGGGVGLSVHGQFRVATERSLFAMPETGIGLFPDVGGGYFLPRLQGKLGYFLALTGYRLKGRDVHRAGIATHFVDSEKLRVLEEELLALKSPSAEDVAGVLESYHAKSKMDQDKSIIFEEHMDKINSCFSANTVEQIIENLRQDGSPFAIEQMKVINKMSPTSLKITLRQLMEGSSKTLQEVLIMEYRITQACMEGHDFHEGVRAVLIDKDQTPKWKPANLKDVTDEDLNSYFKSLGSSDLKF", "length": 385 }, "evidence": [ { "id": "F1MPK4", "url": "https://omabrowser.org/oma/group/F1MPK4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LKJ1-1", "protein_name": "3-hydroxyisobutyryl-CoA hydrolase 1", "gene_name": "CHY1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAVEMASQSQVLVEEKSSVRILTLNRPKQLNALSFHMISRLLQLFLAFEEDPSVKLVILKGHGRAFCAGGDVAAVVRDINQGNWRLGANYFSSEYMLNYVMATYSKAQVSILNGIVMGGGAGVSVHGRFRIATENTVFAMPETALGLFPDVGASYFLSRLPGFFGEYVGLTGARLDGAEMLACGLATHFVPSTRLTALEADLCRINSNDPTFASTILDAYTQHPRLKQQSAYRRLDVIDRCFSRRTVEEIISALEREATQEADGWISATIQALKKGSPASLKISLRSIREGRLQGVGQCLIREYRMVCHVMKGEISKDFVEGCRAILVDKDKNPKWEPRRLEDMKDSMVEQYFERVEREDDLKLPPRNNLPALGIAKL", "length": 378 }, "evidence": [ { "id": "F1MPK4", "url": "https://omabrowser.org/oma/group/F1MPK4/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "3-hydroxyisobutyryl-CoA hydrolase activity", "id": "GO:0003860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003860", "evidence": [ { "database": "UniProtKB", "id": "F1MPK4", "url": "https://www.uniprot.org/uniprotkb/F1MPK4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1MPK4", "url": "https://www.uniprot.org/uniprotkb/F1MPK4" } ], "pmid": "" }, { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "F1MPK4", "url": "https://www.uniprot.org/uniprotkb/F1MPK4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "L-valine catabolic process", "id": "GO:0006574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006574", "evidence": [ { "database": "UniProtKB", "id": "F1MPK4", "url": "https://www.uniprot.org/uniprotkb/F1MPK4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20888", "name": "", "equation": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2TBT3-1", "F1MPK4-1", "Q2HJ73-1" ], "evidence": [ { "id": "20888", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20888" } ] }, { "id": "R-BTA-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-71847" ], "output_participant_list": [], "enzyme_list": [ "F1MPK4-1" ], "evidence": [ { "id": "R-BTA-70881", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-70881" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-71847", "participant_name": "bHIB-CoA [mitochondrial matrix]", "crossref": [ { "id": "62611", "database": "ChEBI", "url": "" }, { "id": "ZINC000008219004", "database": "ZINC", "url": "" }, { "id": "C06000", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F1MPK4", "gene_name": "HIBCH", "activity": [ { "ec_number": "3.1.2.4", "activity": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+).", "evidence": [ { "id": "F1MPK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPK4" } ] }, { "ec_number": "3.1.2.4", "activity": "", "evidence": [ { "id": "F1MPK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPK4" } ] } ] }, { "uniprot_ac": "Q2HJ73", "gene_name": "HIBCH", "activity": [ { "ec_number": "3.1.2.4", "activity": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+).", "evidence": [ { "id": "Q2HJ73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ73" } ] }, { "ec_number": "3.1.2.4", "activity": "", "evidence": [ { "id": "Q2HJ73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJ73" } ] } ] }, { "uniprot_ac": "Q2TBT3", "gene_name": "ECHDC2", "activity": [ { "ec_number": "3.1.2.4", "activity": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+).", "evidence": [ { "id": "Q2TBT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3" } ] }, { "ec_number": "3.1.2.4", "activity": "", "evidence": [ { "id": "Q2TBT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBT3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MPK4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 386, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MPK4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MPK4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MPK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPK4" }, { "id": "PF16113", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16113" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Enoyl-CoA hydratase/isomerase", "eco_id": "ECO_0000259", "start_pos": 47, "end_pos": 376, "start_aa": "Gly", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.2.4", "ec_name": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+).", "evidence": [ { "id": "3.1.2.4", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.4" }, { "id": "3.1.2.4", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.2.4" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 30, "end_pos": 32 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMU9-1", "uniprot_ac": "F1MMU9", "uniprot_id": "F1MMU9_BOVIN", "mass": { "chemical_mass": 225174.0, "monoisotopic_mass": 225174.0 }, "refseq": {}, "gene_names": [ { "name": "SCN8A", "type": "recommended", "evidence": [ { "id": "F1MMU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMU9" } ] } ], "protein_names": [ { "name": "Sodium channel protein", "type": "recommended", "evidence": [ { "id": "F1MMU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMU9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NE86", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NE86#function" }, { "database": "UniProtKB", "id": "RU361132", "url": "https://www.uniprot.org/uniprotkb/RU361132#function" }, { "database": "UniProtKB", "id": "A0A3Q1MLU2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLU2#function" }, { "database": "UniProtKB", "id": "F1MMU9", "url": "https://www.uniprot.org/uniprotkb/F1MMU9#function" } ] }, { "annotation": "Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1NE86", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NE86#function" }, { "database": "UniProtKB", "id": "ARBA00058180", "url": "https://www.uniprot.org/uniprotkb/ARBA00058180#function" }, { "database": "UniProtKB", "id": "A0A3Q1MLU2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLU2#function" }, { "database": "UniProtKB", "id": "F1MMU9", "url": "https://www.uniprot.org/uniprotkb/F1MMU9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMU9", "url": "https://www.uniprot.org/uniprotkb/F1MMU9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCN8A", "url": "https://www.uniprot.org/uniprotkb/F1MMU9", "locus": { "chromosome": "5", "start_pos": 28054725, "end_pos": 28247785, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021339", "url": "https://www.ensembl.org/id/ENSBTAG00000021339" } ] } } ], "crossref": [ { "id": "ENSBTAG00000021339", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021339", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13433", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13433", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008054", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008054", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010526", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010526", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024583", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024583", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044564", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044564", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058542", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058542", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MLU2", "url": "https://www.orthodb.org/?gene=A0A3Q1MLU2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NE86", "url": "https://www.orthodb.org/?gene=A0A3Q1NE86", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MMU9", "url": "https://www.orthodb.org/?gene=F1MMU9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10037", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10037:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10037:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06512", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06512", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11933", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11933", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24609", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24609", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5576892", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5576892", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "34963", "url": "https://www.rhea-db.org/rhea/34963", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MLU2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLU2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLU2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NE86", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NE86", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NE86-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NE86-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMU9", "url": "https://www.uniprot.org/uniprotkb/F1MMU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMU9-1", "url": "https://www.uniprot.org/uniprotkb/F1MMU9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYIVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEDGAGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKGFRLPDNRIGRKFSIMNSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHISGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSILSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWIKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNESSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCNLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESKC", "length": 1979, "header": "tr|F1MMU9-1|F1MMU9_BOVIN Isoform 1 of Sodium channel protein OS=Bos taurus OX=9913 GN=SCN8A PE=3 SV=4 CANONICAL=F1MMU9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MLU2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLU2/entry", "sequence": { "sequence": "MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYIVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEDGAGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKGFRLPDNRIGRKFSIMNSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHISGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSILSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWIKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNESSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCNLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESKC", "length": 1938, "header": "tr|A0A3Q1MLU2-1|F1MMU9_BOVIN Computationally mapped isoform of Sodium channel protein OS=Bos taurus OX=9913 GN=SCN8A PE=3 SV=2 CANONICAL=F1MMU9-1" }, "locus": { "chromosome": "5", "start_pos": 28174485, "end_pos": 28055286, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070241.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070241.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070311.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070311.2" } ] } }, { "isoform_ac": "A0A3Q1NE86-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NE86/entry", "sequence": { "sequence": "MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYIVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEDGAGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKGFRLPDNRIGRKFSIMNSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHISGRLLPEVKIDKAATDDSATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSILSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWIKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNESSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCNLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESKC", "length": 1990, "header": "tr|A0A3Q1NE86-1|F1MMU9_BOVIN Computationally mapped isoform of Sodium channel protein OS=Bos taurus OX=9913 GN=SCN8A PE=3 SV=2 CANONICAL=F1MMU9-1" }, "locus": { "chromosome": "5", "start_pos": 28174485, "end_pos": 28055286, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079634.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079634.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069895.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069895.2" } ] } }, { "isoform_ac": "F1MMU9-1", "url": "https://www.uniprot.org/uniprotkb/F1MMU9/entry", "sequence": { "sequence": "MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYIVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEDGAGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKGFRLPDNRIGRKFSIMNSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHISGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSILSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWIKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNESSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCNLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESKC", "length": 1979, "header": "tr|F1MMU9-1|F1MMU9_BOVIN Isoform 1 of Sodium channel protein OS=Bos taurus OX=9913 GN=SCN8A PE=3 SV=4 CANONICAL=F1MMU9-1" }, "locus": { "chromosome": "5", "start_pos": 28174485, "end_pos": 28055286, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061543.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061543.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053165.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053165.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 109, "start_aa": "Thr", "end_pos": 109, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr109", "evidence": [ { "id": "", "database": "GlyGen", 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Classification" ] }, { "id": "bta:614323", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614323", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LHPDMHI", "url": "https://omabrowser.org/oma/group/LHPDMHI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0C1", "url": "https://www.orthodb.org/?gene=A0A3Q1M0C1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NIM8", "url": "https://www.orthodb.org/?gene=A0A3Q1NIM8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MPL2", "url": "https://www.orthodb.org/?gene=F1MPL2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR18952", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18952", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18952:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18952:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00194", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00194", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1475029", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1475029", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005211801", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211801", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10748", "url": "https://www.rhea-db.org/rhea/10748", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M0C1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0C1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0C1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0C1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NIM8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NIM8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NIM8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NIM8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPL2", "url": "https://www.uniprot.org/uniprotkb/F1MPL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPL2-1", "url": "https://www.uniprot.org/uniprotkb/F1MPL2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLRSLHAAAVLLLVVLKEQPSSPAPLNGSKWTYIGPDGEKSWSKTYPSCGGLLQSPIDLHDDILRYNASLRPLAFQGYNQSASPQFVLTNNGHSVKVKLPKDMQVRGLGARYNASQLHLHWGDKNDPHGSEHTVGGEHFAAELHIVYYNSDRYPNDSFAKDKPEGLAVVAVLIEVGSSNPAYDKIFDHLKDVKYKGQEVFIPGFSIEELLPERPEEYYRYRGSLTTPPCYPTVLWTVFRNPVQISQEQLMKLETDLYCTHMDDPSPREMVNNFRRVQKFDERLVYVSFQQVPDPPCTGLSPGIVLSVALACGLGICIVLAVSIWLLRRRKSSKKGANKGVIYKPAIKQETEAHA", "length": 355, "header": "tr|F1MPL2-1|F1MPL2_BOVIN Isoform 1 of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA12 PE=3 SV=3 CANONICAL=F1MPL2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0C1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0C1/entry", "sequence": { "sequence": "MPLRSLHAAAVLLLVVLKEQPSSPAPLNGSKWTYIGPDGEKSWSKTYPSCGGLLQSPIDLHDDILRYNASLRPLAFQGYNQSASPQFVLTNNGHSVKVKLPKDMQVRGLGARYNASQLHLHWGDKNDPHGSEHTVGGEHFAAELHIVYYNSDRYPNDSFAKDKPEGLAVVAVLIEVGSSNPAYDKIFDHLKDVKYKGQEVFIPGFSIEELLPERPEEYYRYRGSLTTPPCYPTVLWTVFRNPVQISQEQLMKLETDLYCTHMDDPSPREMVNNFRRVQKFDERLVYVSFQQGIVLSVALACGLGICIVLAVSIWLLRRRKSSKKGANKGVIYKPAIKQETEAHA", "length": 344, "header": "tr|A0A3Q1M0C1-1|F1MPL2_BOVIN Computationally mapped isoform of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA12 PE=3 SV=1 CANONICAL=F1MPL2-1" }, "locus": { "chromosome": "10", "start_pos": 46711747, "end_pos": 46649404, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081611.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081611.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063404.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063404.1" } ] } }, { "isoform_ac": "A0A3Q1NIM8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NIM8/entry", "sequence": { "sequence": "MPLRSLHAAAVLLLVVLKEQPSSPAPLNGSKWTYIVKVKLPKDMQVRGLGARYNASQLHLHWGDKNDPHGSEHTVGGEHFAAELHIVYYNSDRYPNDSFAKDKPEGLAVVAVLIEVGSSNPAYDKIFDHLKDVKYKGQEVFIPGFSIEELLPERPEEYYRYRGSLTTPPCYPTVLWTVFRNPVQISQEQLMKLETDLYCTHMDDPSPREMVNNFRRVQKFDERLVYVSFQQGIVLSVALACGLGICIVLAVSIWLLRRRKSSKKGANKGVIYKPAIKQETEAHA", "length": 284, "header": "tr|A0A3Q1NIM8-1|F1MPL2_BOVIN Computationally mapped isoform of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA12 PE=3 SV=2 CANONICAL=F1MPL2-1" }, "locus": { "chromosome": "10", "start_pos": 46711747, "end_pos": 46649404, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073465.3", "url": "https://www.ensembl.org/id/ENSBTAT00000073465.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071897.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071897.2" } ] } }, { "isoform_ac": "F1MPL2-1", "url": "https://www.uniprot.org/uniprotkb/F1MPL2/entry", "sequence": { "sequence": "MPLRSLHAAAVLLLVVLKEQPSSPAPLNGSKWTYIGPDGEKSWSKTYPSCGGLLQSPIDLHDDILRYNASLRPLAFQGYNQSASPQFVLTNNGHSVKVKLPKDMQVRGLGARYNASQLHLHWGDKNDPHGSEHTVGGEHFAAELHIVYYNSDRYPNDSFAKDKPEGLAVVAVLIEVGSSNPAYDKIFDHLKDVKYKGQEVFIPGFSIEELLPERPEEYYRYRGSLTTPPCYPTVLWTVFRNPVQISQEQLMKLETDLYCTHMDDPSPREMVNNFRRVQKFDERLVYVSFQQVPDPPCTGLSPGIVLSVALACGLGICIVLAVSIWLLRRRKSSKKGANKGVIYKPAIKQETEAHA", "length": 355, "header": "tr|F1MPL2-1|F1MPL2_BOVIN Isoform 1 of Carbonic anhydrase OS=Bos taurus OX=9913 GN=CA12 PE=3 SV=3 CANONICAL=F1MPL2-1" }, "locus": { "chromosome": "10", "start_pos": 46711747, "end_pos": 46649404, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025837.8", "url": "https://www.ensembl.org/id/ENSBTAT00000025837.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025837.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025837.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:614323", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:614323", "resource": "KEGG Pathway" }, { "id": "R-BTA-1475029", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1475029", "resource": "Reactome", "description": "Reversible hydration of carbon dioxide" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BC72-1", "protein_name": "Carbonic anhydrase", "gene_name": "CA12", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPHRNLHAAAVLLLLVLKEQPSSPAPLNGSKWTYLGPNGEKSWSKSYPSCGGLLQSPIDLHGDILQYNASLVPLAFQGYNETANQQFVLTNNGHSVKLKLFEDMHIQGLGHRYNASQLHLHWGDQNEPHGSEHTIGGKHFAAELHIVYFNSDLYPNASIASDKPEGLAVLAVLIEMGSFNPSYDKIFSHLPDVKYKDQKVHIPGFSIEELLPERPEEYYRYRGSLTTPPCHPTVLWTVFRNPVQISQEQLLALETVLYCTHMDDPSPREMVNNFRQVQKFDERLVYVSFRQVPDSTYAGLNLGIILSVAVAGVLGICVVLAVSIWLFRRKKSSKKGANKGVIYKPAIKQETEAHA", "length": 355 }, "evidence": [ { "id": "F1MPL2", "url": "https://omabrowser.org/oma/group/F1MPL2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0ZXU7-1", "protein_name": "Carbonic anhydrase", "gene_name": "CA12", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSVKSCNRALVTPVLIFFLKIQLSVPASLNGSKWSYIGPDGENTWPKKYPFCGGVFQSPIDFHKDILQYDSNLSPLEFIGYNVSSTDQFTLTNNGHSVKMHLSPTMHIRNLPFEYTASQLHLHWGNRNKSEGSEHTVSGKHFAAEVHIVHYNSEKYPDIAAAMDKANGLAVLAILLEIGPFNPSYEKIFRHFRNVKYKDQMVHVPGFNVQELLPDRPDEYYRYEGSLTTPPCYPSVLWTVFRHPVKISQEQLLALETAMYCTESDDPEPLEMVNNFRNVQEFRERLVFISFREGVLVSVVIACIVGVLLFLVVACCLCRRKSCTKEGNREVTYTQGTQQKEEAISKL", "length": 347 }, "evidence": [ { "id": "F1MPL2", "url": "https://omabrowser.org/oma/group/F1MPL2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F7FAJ9-1", "protein_name": "Carbonic anhydrase", "gene_name": "Ca12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPHCSLHATVVLLLVILKEQPSSSAPLNGSKWTYIGPAGEKNWSKKYPSCGGLLQSPIDLHSDILQYDASLAPLQFQGYNVSVEKLLNLTNDGHSVRLNLNSDMYIQGLQPHQYRAEQLHLHWGNRNDPHGSEHTVSGKHFAAELHIVHYNSDLYSDFGSASDKSEGLAVLAVLIEIGSVNPSYDKIFSHLQHVKYKGQQVLIPGFNIEELLPESPGEYYRYEGSLTTPPCYPTVLWTVFRNPVQISQEQLLALETALYFTHMDDPSPREMVNNFRQVQKFDERLVYISFRQVGLLTDTGLSLGIILSVALAGVLGISIVLAVSVWLFKRKKSKKGDNKGVIYKPAIKKEAEVHA", "length": 355 }, "evidence": [ { "id": "F1MPL2", "url": "https://omabrowser.org/oma/group/F1MPL2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O43570-1", "protein_name": "Carbonic anhydrase 12", "gene_name": "CA12", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA", "length": 354 }, "evidence": [ { "id": "F1MPL2", "url": "https://omabrowser.org/oma/group/F1MPL2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CI85-1", "protein_name": "Carbonic anhydrase 12", "gene_name": "Ca12", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPHRSLRATVVLLLVILKKQPSSSAPLNGSKWTYVGPAGEKNWSKKYPSCGGLLQSPIDLHSDILQYDASLAPLQFQGYNVSVEKLLNLTNDGHSVRLNLNSDMYIQGLQPHHYRAEQLHLHWGNRNDPHGSEHTVSGKHFAAELHIVHYNSDLYPDFSTASDKSEGLAVLAVLIEIGSANPSYDKIFSHLQHVKYKGQQVLIPGFNIEELLPESPGEYYRYEGSLTTPPCYPTVLWTVFRNPVQISQEQLLALETALYFTHMDDPTPREMINNFRQVQKFDERLVYISFRQGLLTDTGLSLGIILSVALAGVLGISIVLAVSIWLFKRKKSKKGDNKGVIYKPAIKKEAEVHA", "length": 354 }, "evidence": [ { "id": "F1MPL2", "url": "https://omabrowser.org/oma/group/F1MPL2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MPL2", "url": "https://www.uniprot.org/uniprotkb/F1MPL2" } ], "pmid": "" }, { "name": "carbonate dehydratase activity", "id": "GO:0004089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004089", "evidence": [ { "database": "UniProtKB", "id": "F1MPL2", "url": "https://www.uniprot.org/uniprotkb/F1MPL2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MPL2", "url": "https://www.uniprot.org/uniprotkb/F1MPL2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "chloride ion homeostasis", "id": "GO:0055064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055064", "evidence": [ { "database": "UniProtKB", "id": "F1MPL2", "url": "https://www.uniprot.org/uniprotkb/F1MPL2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 156, "end_pos": 158, "annotation": "n_glycosylation_sequon" }, { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" }, { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10748", "name": "", "equation": "hydrogencarbonate + H(+) = CO2 + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1N5D1-1", "G3MX64-1", "E1BAD9-1", "E1BHA4-1", "F1MBS0-1", "F1MPL2-1", "Q95323-1", "P00921-1", "P18915-1", "Q1LZA1-1", "Q3SZX4-1", "F1N0H3-1", "E1BPA4-1", "A0A0A0MP99-1", "A0A3Q1LYT6-1" ], "evidence": [ { "id": "10748", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10748" } ] }, { "id": "R-BTA-1475017", "name": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [ "R-ALL-425425" ], "output_participant_list": [], "enzyme_list": [ "E1BHD3-1", "E1BPA4-1", "F1MPL2-1", "Q95323-1" ], "evidence": [ { "id": "R-BTA-1475017", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1475017" } ] }, { "id": "R-BTA-1475025", "name": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BHD3-1", "E1BPA4-1", "F1MPL2-1", "Q95323-1" ], "evidence": [ { "id": "R-BTA-1475025", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1475025" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-425425", "participant_name": "HCO3- [extracellular region]", "crossref": [ { "id": "17544", "database": "ChEBI", "url": "" }, { "id": "11533114", "database": "PubChem Substance", "url": "" }, { "id": "C00288", "database": "COMPOUND", "url": "" }, { "id": "ZINC000006827693", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0A0MP99", "gene_name": "LOC100847874", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] }, { "ec_number": "4.2.1.69", "activity": "urea = cyanamide + H2O.", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] }, { "ec_number": "4.2.1.69", "activity": "", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "A0A0A0MP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MP99" } ] } ] }, { "uniprot_ac": "A0A3Q1LYT6", "gene_name": "LOC784254", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "A0A3Q1LYT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "A0A3Q1LYT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYT6" } ] } ] }, { "uniprot_ac": "E1BAD9", "gene_name": "CA5A", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "E1BAD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "E1BAD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAD9" } ] } ] }, { "uniprot_ac": "E1BHA4", "gene_name": "CA7", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "E1BHA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHA4" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "E1BHA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHA4" } ] } ] }, { "uniprot_ac": "E1BHD3", "gene_name": "CA14", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "E1BHD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHD3" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "E1BHD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHD3" } ] } ] }, { "uniprot_ac": "E1BPA4", "gene_name": "CA9", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "E1BPA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA4" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "E1BPA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA4" } ] } ] }, { "uniprot_ac": "F1MBS0", "gene_name": "CA6", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "F1MBS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBS0" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "F1MBS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBS0" } ] } ] }, { "uniprot_ac": "F1MPL2", "gene_name": "CA12", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "F1MPL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPL2" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "F1MPL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPL2" } ] } ] }, { "uniprot_ac": "F1N0H3", "gene_name": "CA2", "activity": [ { "ec_number": "4.2.1.1", "activity": "hydrogencarbonate + H(+) = CO2 + H2O.", "evidence": [ { "id": "F1N0H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0H3" } ] }, { "ec_number": "4.2.1.1", "activity": "", "evidence": [ { "id": "F1N0H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N0H3" } ] } ] }, { "uniprot_ac": "F1N5D1", 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"annotation": "Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RUX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUX6#function" }, { "database": "UniProtKB", "id": "ARBA00037274", "url": "https://www.uniprot.org/uniprotkb/ARBA00037274#function" }, { "database": "UniProtKB", "id": "F1MJT6", "url": "https://www.uniprot.org/uniprotkb/F1MJT6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJT6", "url": "https://www.uniprot.org/uniprotkb/F1MJT6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CKMT2", "url": "https://www.uniprot.org/uniprotkb/F1MJT6", "locus": { "chromosome": "7", "start_pos": 81274992, "end_pos": 81249468, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001003", "url": "https://www.ensembl.org/id/ENSBTAG00000001003" } ] } } ], "crossref": [ { "id": "F1MJT6", "url": "https://alphafold.ebi.ac.uk/entry/F1MJT6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001003", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001003", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00716", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00716", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014746", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014746", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022413", "url": 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{ "id": "PTHR11547:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11547:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00217", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00217", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02807", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02807", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-71288", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71288", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RUX6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJT6", "url": "https://www.uniprot.org/uniprotkb/F1MJT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJT6-1", "url": "https://www.uniprot.org/uniprotkb/F1MJT6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASTFSKLLTGRNASLLFATLGTGALTTGYLLNKQNVCAAAREQHKLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPSGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHPTDLDASKITQGQFDERYVLSSRVRTGRSIRGLSLPPACSRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK", "length": 419, "header": "tr|F1MJT6-1|F1MJT6_BOVIN Isoform 1 of Creatine kinase S-type, mitochondrial OS=Bos taurus OX=9913 GN=CKMT2 PE=3 SV=1 CANONICAL=F1MJT6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUX6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUX6/entry", "sequence": { "sequence": "WCSQISRSLDSRPGPHTCCTAFWNADYPDLRKHNNCMAECLTPAIYAKLRNKVTPSGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHPTDLDASKITQGQFDERYVLSSRVRTGRSIRGLSLPPACSRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK", "length": 392, "header": "tr|A0AAA9RUX6-1|F1MJT6_BOVIN Computationally mapped isoform of Creatine kinase S-type, mitochondrial OS=Bos taurus OX=9913 GN=CKMT2 PE=3 SV=1 CANONICAL=F1MJT6-1" }, "locus": { "chromosome": "7", "start_pos": 81274849, "end_pos": 81260959, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135299.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135299.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076021.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076021.1" } ] } }, { "isoform_ac": "F1MJT6-1", "url": "https://www.uniprot.org/uniprotkb/F1MJT6/entry", "sequence": { "sequence": "MASTFSKLLTGRNASLLFATLGTGALTTGYLLNKQNVCAAAREQHKLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPSGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHPTDLDASKITQGQFDERYVLSSRVRTGRSIRGLSLPPACSRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK", "length": 419, "header": "tr|F1MJT6-1|F1MJT6_BOVIN Isoform 1 of Creatine kinase S-type, mitochondrial OS=Bos taurus OX=9913 GN=CKMT2 PE=3 SV=1 CANONICAL=F1MJT6-1" }, "locus": { "chromosome": "7", "start_pos": 81274849, "end_pos": 81260469, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001330.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001330.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001330.2", "url": "https://www.ensembl.org/id/ENSBTAP00000001330.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-71288", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-71288", "resource": "Reactome", "description": "Creatine metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3L7I8A6-1", "protein_name": "Creatine kinase S-type, mitochondrial", "gene_name": "Ckmt2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MASAFSKLLTGRNASLLFTTLGTSALTTGYLLNRQKVSADAREQHKLFPASADYPDLRKHNNCMAECLTPTIYAKLRNKMTPNGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHPTDLDASKITHGQFDERYVLSSRVRTGRSIRGLSLPPACSRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVKIPKLSKDPRFSKILENLRLQKRGTGGVDTAAVADIYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFSRK", "length": 419 }, "evidence": [ { "id": "F1MJT6", "url": "https://omabrowser.org/oma/group/F1MJT6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1NAD3-1", "protein_name": "Creatine kinase S-type, mitochondrial", "gene_name": "CKMT2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGTFGRLLAGRVTAALFAAAGTGVLTTGYLLNQQNVKATVHEKRKLFPPSADYPDLRKHNNCMAECLTPAIYAKLRDKLTPNGYSLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFAEIFDPVIKARHNGYDPRTMKHHTDLDASKITHGQFDERYVLSSRVRTGRSIRGLSLPPACSRAERREVENVVVTALAGLKGDLSGKYYSLTNMSERDQQQLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNNDKTFLVWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIKERGWEFMWNERLGYVLTCPSNLGTGLRAGVHVKLPRLSKDPRFPKILENLRLQKRGTGGVDTAAVADVYDISNLDRMGRSEVELVQIVIDGVNYLVDCEKKLEKGQDIKVPPPLPQFGRK", "length": 419 }, "evidence": [ { "id": "F1MJT6", "url": "https://omabrowser.org/oma/group/F1MJT6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P09605-1", "protein_name": "Creatine kinase S-type, mitochondrial", "gene_name": "Ckmt2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASAFSKLLTGRNASLLFTTLGTSALTTGYLLNRQKVSADAREQHKLFPPSADYPDLRKHNNCMAECLTPTIYAKLRNKMTPSGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRLMKHPADLDASKITHGQFDERYVLSSRVRTGRSIRGLSLPPACSRAERREVENVAITALGGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGRK", "length": 419 }, "evidence": [ { "id": "F1MJT6", "url": "https://omabrowser.org/oma/group/F1MJT6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P17540-1", "protein_name": "Creatine kinase S-type, mitochondrial", "gene_name": "CKMT2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASIFSKLLTGRNASLLFATMGTSVLTTGYLLNRQKVCAEVREQPRLFPPSADYPDLRKHNNCMAECLTPAIYAKLRNKVTPNGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHTTDLDASKITQGQFDEHYVLSSRVRTGRSIRGLSLPPACTRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK", "length": 419 }, "evidence": [ { "id": "F1MJT6", "url": "https://omabrowser.org/oma/group/F1MJT6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6P8J7-1", "protein_name": "Creatine kinase S-type, mitochondrial", "gene_name": "Ckmt2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASAFSKLLTGRNASLLFTTLGTSALTTGYLLNRQKVSADAREQHKLFPPSADYPDLRKHNNCMAECLTPTIYAKLRNKMTPSGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHPTDLDASKITHGQFDERYVLSSRVRTGRSIRGLSLPPACSRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGRK", "length": 419 }, "evidence": [ { "id": "F1MJT6", "url": "https://omabrowser.org/oma/group/F1MJT6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VF23-1", "protein_name": "arginine kinase", "gene_name": "Argk3", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTSIESKRVQYRKYLERAGVIDALSKALIKLYEEQNKPEDAIRFVRKFMCESCPDDAQYDVMKNDLEEAKTHISKLEQELERLRGQIKKSPEEYQELTTEGYKSLMDDEENVSSLLRKYLTPELLEEYMLVTTPAPVDAYLYDCAVSGFEHHDAPVGIFAADADSYDVFNKLFDPIIKDYHGQMDNENDVLQKDPDFGNVDEIENLDPERKYILSARIRLARNIEGLPFFPKLTEKQFIEVEEKVRSATETMDGELIGSYLTMADIDAETQAEMVKRHILFQRGDEKLTTAGCYRFWPTGRGVYHNPAETFLIWVNRQDHVHIMSMAQCGDLGDVYNRLVNGLTELEKTLAFARHPRYGNLTACPTNLGTTLRASVHIRLPLLSKDPDRLLALAEEQQLQVRGTDGGELSTVEDGVMDISNKRKLGFTEFELVKTLQDGVVTLINAEEELEISGQEG", "length": 457 }, "evidence": [ { "id": "F1MJT6", "url": "https://omabrowser.org/oma/group/F1MJT6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "phosphocreatine biosynthetic process", "id": "GO:0046314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046314", "evidence": [ { "database": "UniProtKB", "id": "F1MJT6", "url": "https://www.uniprot.org/uniprotkb/F1MJT6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "creatine kinase activity", "id": "GO:0004111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004111", "evidence": [ { "database": "UniProtKB", "id": "F1MJT6", "url": "https://www.uniprot.org/uniprotkb/F1MJT6" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MJT6", "url": "https://www.uniprot.org/uniprotkb/F1MJT6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "F1MJT6", "url": "https://www.uniprot.org/uniprotkb/F1MJT6" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1MJT6", "url": "https://www.uniprot.org/uniprotkb/F1MJT6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 13, "end_pos": 15, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-200326", "name": "creatine + ATP => phosphocreatine + ADP [CK octamer]", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial inner membrane", "input_participant_list": [ "R-ALL-29916" ], "output_participant_list": [ "R-ALL-200351" ], "enzyme_list": [ "Q9TTK8-1", "F1MJT6-1" ], "evidence": [ { "id": "R-BTA-200326", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-200326" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-200351", "participant_name": "Pcr [cytosol]", "crossref": [ { "id": "58092", "database": "ChEBI", "url": "" }, { "id": "ZINC000003869774", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-29916", "participant_name": "CRET [cytosol]", "crossref": [ { "id": "ZINC000003861770", "database": "ZINC", "url": "" }, { "id": "57947", "database": "ChEBI", "url": "" }, { "id": "C00300", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F1MJT6", "gene_name": "CKMT2", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "F1MJT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJT6" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "F1MJT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJT6" } ] } ] }, { "uniprot_ac": "Q9TTK8", "gene_name": "CKMT1", "activity": [ { "ec_number": "2.7.3.2", "activity": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ] }, { "ec_number": "2.7.3.2", "activity": "", "evidence": [ { "id": "Q9TTK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q9TTK8" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJT6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 419, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJT6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJT6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJT6" }, { "id": "PS51510", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51510" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosphagen kinase C-terminal", "eco_id": "ECO_0000259", "start_pos": 159, "end_pos": 401, "start_aa": "Tyr", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJT6" }, { "id": "PS51509", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51509" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Phosphagen kinase N-terminal", "eco_id": "ECO_0000259", "start_pos": 46, "end_pos": 132, "start_aa": "Lys", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.3.2", "ec_name": "creatine + ATP = N-phosphocreatine + ADP + H(+).", "evidence": [ { "id": "2.7.3.2", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2" }, { "id": "2.7.3.2", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.3.2" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 13, "end_pos": 15 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MLE3-1", "uniprot_ac": "F1MLE3", "uniprot_id": "F1MLE3_BOVIN", "mass": { "chemical_mass": 71507.0, "monoisotopic_mass": 71507.0 }, "refseq": {}, "gene_names": [ { "name": "COG6", "type": "recommended", "evidence": [ { "id": "F1MLE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLE3" } ] } ], "protein_names": [ { "name": "Conserved oligomeric Golgi complex subunit 6", "type": "recommended", "evidence": [ { "id": "F1MLE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLE3/entry#names_and_taxonomy" } ] }, { "name": "COG complex subunit 6", "type": "synonym", "evidence": [ { "id": "F1MLE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLE3/entry#names_and_taxonomy" } ] }, { "name": "Component of oligomeric Golgi complex 6", "type": "synonym", "evidence": [ { "id": "F1MLE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLE3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for normal Golgi function.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9RVJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVJ3#function" }, { "database": "UniProtKB", "id": "RU365075", "url": "https://www.uniprot.org/uniprotkb/RU365075#function" }, { "database": "UniProtKB", "id": "ARBA00003627", "url": "https://www.uniprot.org/uniprotkb/ARBA00003627#function" }, { "database": "UniProtKB", "id": "A0AAA9TT09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT09#function" }, { "database": "UniProtKB", "id": "F1MLE3", "url": "https://www.uniprot.org/uniprotkb/F1MLE3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MLE3", "url": "https://www.uniprot.org/uniprotkb/F1MLE3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COG6", "url": "https://www.uniprot.org/uniprotkb/F1MLE3", "locus": { "chromosome": "12", "start_pos": 22698525, "end_pos": 22753200, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016635", "url": "https://www.ensembl.org/id/ENSBTAG00000016635" } ] } } ], "crossref": [ { "id": "F1MLE3", "url": "https://alphafold.ebi.ac.uk/entry/F1MLE3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016635", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016635", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR010490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048368", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048368", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048369", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048369", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MLE3", "url": "https://www.orthodb.org/?gene=F1MLE3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21506", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21506", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21506:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21506:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06419", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06419", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF20653", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20653", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811438", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RVJ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RVJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT09", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLE3", "url": "https://www.uniprot.org/uniprotkb/F1MLE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLE3-1", "url": "https://www.uniprot.org/uniprotkb/F1MLE3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEGSGEVVVVPATGAANGLNNGAGGTSAQTSNPLSRKLRKILDTRLDNDKDMLEALKALSTFFVENSLRTRRNLRGDIERRSLAINEEFVSIFKEVKEELESIHEDVQAMSSCCQDMTSRLQAAKEQTQDLIVKTTKLQAESQRLEIRAQVADAFLSKFQLTSDEMSLLRGTREGPITEDFFKALGRVKQIHNDVKVLLRTNQQTAGLEIMEQMALLQETSYERLYRWAQSECRTLTQESCDISPVLTQAMEALQDRPVLYKYTLDEFGTARRSTVVRGFIDALTRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTAQGVEENIQEVVGHITEGVCRPLKVRIEQVIVAEPGAVLLYKISNLLKFYHHTISGIIGNSATTLLTTIEEMHLLSKKIFFNSLSLHASKLMDKVELPPPDLGPSSALNQTLVLLREVLASHDSSVVPLDARQADFVQVLSCVLDPLLQMCTVSASHLGTADMATFLVNSLYMMKTTLALFEFTDRRLEMLQFQIEAHLDTLINEQASYVLTRAGLSYIYNMVQQHKVEQVQFDRYLSAPDNLLMPQLNFLLSATVKEQIIKQSTELVCRAYGEVYAAVMNPVNEYKDPGSILHRSPQQVQTLLS", "length": 639, "header": "tr|F1MLE3-1|F1MLE3_BOVIN Isoform 1 of Conserved oligomeric Golgi complex subunit 6 OS=Bos taurus OX=9913 GN=COG6 PE=3 SV=2 CANONICAL=F1MLE3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RVJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVJ3/entry", "sequence": { "sequence": "MAEGSGEVVVVPATGAANGLNNGAGGTSAQTSNPLSRKLRKILDTRLDNDKDMLEALKALSTFFVENSLRTRRNLRGDIERRSLAINEEFVSIFKEVKEELESIHEDVQAMSSCCQDMTSRLQAAKEQTQDLIVKTTKLQAESQRLEIRAQVADAFLSKFQLTSDEMSLLRGTREGPITEDFFKALGRVKQIHNDVKVLLRTNQQTAGLEIMEQMALLQETSYERLYRWAQSECRTLTQESCDISPVLTQAMEALQDRPVLYKYTLDEFGTARRSTVVRGFIDALTRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTAQGVEENIQEVVGHITEGVCRPLKVRIEQVIVAEPGAVLLYKISNLLKFYHHTISGIIGNSATTLLTTIEEMHLLSKKIFFNSLSLHASKLMDKVELPPPDLGPSSALNQTLVLLREVLASHDSSVVPLDARQADFVQIEAHLDTLINEQASYVLTRAGLSYIYNMVQQHKVEQGPLANLPNLDSVALKAAMVQFDRYLSAPDNLLMPQLNFLLSATVKEQIIKQSTELVCRAYGEVYAAVMNPVNEYKDPGSILHRSPQQVQTLLS", "length": 601, "header": "tr|A0AAA9RVJ3-1|F1MLE3_BOVIN Computationally mapped isoform of Conserved oligomeric Golgi complex subunit 6 OS=Bos taurus OX=9913 GN=COG6 PE=3 SV=1 CANONICAL=F1MLE3-1" }, "locus": { "chromosome": "12", "start_pos": 22753037, "end_pos": 22699796, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125004.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125004.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074994.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074994.1" } ] } }, { "isoform_ac": "A0AAA9TT09-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT09/entry", "sequence": { "sequence": "MGPAGPRRRPATRCRGNCVRSWTPGWTTTSLRTRRNLRGDIERRSLAINEEFVSIFKEVKEELESIHEDVQAMSSCCQDMTSRLQAAKEQTQDLIVKTTKLQAESQRLEIRAQVADAFLSKFQLTSDEMSLLRGTREGPITEDFFKALGRVKQIHNDVKVLLRTNQQTAGLEIMEQMALLQETSYERLYRWAQSECRTLTQESCDISPVLTQAMEALQDRPVLYKYTLDEFGTARRSTVVRGFIDALTRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTAQGVEENIQEVVGHITEGVCRPLKVRIEQVIVAEPGAVLLYKISNLLKFYHHTISGIIGNSATTLLTTIEEMHLLSKKIFFNSLSLHASKLMDKVELPPPDLGPSSALNQTLVLLREVLASHDSSVVPLDARQADFVQVLSCVLDPLLQMCTVSASHLGTADMATFLVNSLYMMKTTLALFEFTDRRLEMLQFQIEAHLDTLINEQASYVLTRAGLSYIYNMVQQHKVEQGPLANLPNLDSVALKAAMVQFDRYLSAPDNLLMPQLNFLLSATVKEQIIKQSTELVCRAYGEVYAAVMNPVNEYKDPGSILHRSPQQVQTLLS", "length": 619, "header": "tr|A0AAA9TT09-1|F1MLE3_BOVIN Computationally mapped isoform of Conserved oligomeric Golgi complex subunit 6 OS=Bos taurus OX=9913 GN=COG6 PE=3 SV=1 CANONICAL=F1MLE3-1" }, "locus": { "chromosome": "12", "start_pos": 22752973, "end_pos": 22699796, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116523.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116523.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099652.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099652.1" } ] } }, { "isoform_ac": "F1MLE3-1", "url": "https://www.uniprot.org/uniprotkb/F1MLE3/entry", "sequence": { "sequence": "MAEGSGEVVVVPATGAANGLNNGAGGTSAQTSNPLSRKLRKILDTRLDNDKDMLEALKALSTFFVENSLRTRRNLRGDIERRSLAINEEFVSIFKEVKEELESIHEDVQAMSSCCQDMTSRLQAAKEQTQDLIVKTTKLQAESQRLEIRAQVADAFLSKFQLTSDEMSLLRGTREGPITEDFFKALGRVKQIHNDVKVLLRTNQQTAGLEIMEQMALLQETSYERLYRWAQSECRTLTQESCDISPVLTQAMEALQDRPVLYKYTLDEFGTARRSTVVRGFIDALTRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTAQGVEENIQEVVGHITEGVCRPLKVRIEQVIVAEPGAVLLYKISNLLKFYHHTISGIIGNSATTLLTTIEEMHLLSKKIFFNSLSLHASKLMDKVELPPPDLGPSSALNQTLVLLREVLASHDSSVVPLDARQADFVQVLSCVLDPLLQMCTVSASHLGTADMATFLVNSLYMMKTTLALFEFTDRRLEMLQFQIEAHLDTLINEQASYVLTRAGLSYIYNMVQQHKVEQVQFDRYLSAPDNLLMPQLNFLLSATVKEQIIKQSTELVCRAYGEVYAAVMNPVNEYKDPGSILHRSPQQVQTLLS", "length": 639, "header": "tr|F1MLE3-1|F1MLE3_BOVIN Isoform 1 of Conserved oligomeric Golgi complex subunit 6 OS=Bos taurus OX=9913 GN=COG6 PE=3 SV=2 CANONICAL=F1MLE3-1" }, "locus": { "chromosome": "12", "start_pos": 22753037, "end_pos": 22699796, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022131.4", "url": "https://www.ensembl.org/id/ENSBTAT00000022131.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022131.3", "url": "https://www.ensembl.org/id/ENSBTAP00000022131.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 293, "start_aa": "Thr", "end_pos": 293, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr293", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" }, { "id": "R-BTA-6811438", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "resource": "Reactome", "description": "Intra-Golgi traffic" }, { "id": "R-BTA-6811440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "resource": "Reactome", "description": "Retrograde transport at the Trans-Golgi-Network" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F1MLE3", "url": "https://www.uniprot.org/uniprotkb/F1MLE3" } ], "pmid": "" }, { "name": "Golgi transport complex", "id": "GO:0017119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017119", "evidence": [ { "database": "UniProtKB", "id": "F1MLE3", "url": "https://www.uniprot.org/uniprotkb/F1MLE3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1MLE3", "url": "https://www.uniprot.org/uniprotkb/F1MLE3" } ], "pmid": "" }, { "name": "intra-Golgi vesicle-mediated transport", "id": "GO:0006891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006891", "evidence": [ { "database": "UniProtKB", "id": "F1MLE3", "url": "https://www.uniprot.org/uniprotkb/F1MLE3" } ], "pmid": "" }, { "name": "Golgi organization", "id": "GO:0007030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", "evidence": [ { "database": "UniProtKB", "id": "F1MLE3", "url": "https://www.uniprot.org/uniprotkb/F1MLE3" } ], "pmid": "" }, { "name": "retrograde transport, vesicle recycling within Golgi", "id": "GO:0000301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000301", "evidence": [ { "database": "UniProtKB", "id": "F1MLE3", "url": "https://www.uniprot.org/uniprotkb/F1MLE3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 443, "end_pos": 445, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MLE3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 639, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MLE3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MLE3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MLE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLE3" }, { "id": "PF20653", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20653" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Conserved Oligomeric Golgi complex subunit 6 C-terminal", "eco_id": "ECO_0000259", "start_pos": 205, "end_pos": 638, "start_aa": "Gln", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MLE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLE3" }, { "id": "PF06419", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06419" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Conserved oligomeric complex COG6 N-terminal", "eco_id": "ECO_0000259", "start_pos": 60, "end_pos": 172, "start_aa": "Leu", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 293 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 443, "end_pos": 445 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MTK4-1", "uniprot_ac": "F1MTK4", "uniprot_id": "F1MTK4_BOVIN", "mass": { "chemical_mass": 59303.0, "monoisotopic_mass": 59303.0 }, "refseq": { "ac": "XP_024837180", "name": "lysophosphatidylcholine acyltransferase 1 isoform X1", 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Gene", "id": "ENSBTAG00000035110", "url": "https://www.ensembl.org/id/ENSBTAG00000035110" } ] } } ], "crossref": [ { "id": "F1MMN4", "url": "https://alphafold.ebi.ac.uk/entry/F1MMN4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000035110", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000035110", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "537776", "url": "https://www.ncbi.nlm.nih.gov/gene/537776", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR031470", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031470", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057656", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057656", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537776", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537776", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR18875", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18875", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR18875:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18875:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17045", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17045", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25771", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25771", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059738965", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059738965", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S2E4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S2E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2E4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7S6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7S6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLS0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN18", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN18", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SN18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN18-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMN4", "url": "https://www.uniprot.org/uniprotkb/F1MMN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMN4-1", "url": "https://www.uniprot.org/uniprotkb/F1MMN4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPVEFNVLLRIFASVFTRASPCEAELQELMEQIDIMVNNKKLDWERKMRALETRLDLRDQELANAQTCLEQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQTLKAQFSKLTNSFEKLRLHQLKQNKFRRKEVPHLKEEMPFELNSLNQKLEEFRAKSREWDKQEILYQTHLVSLDAQQKILSEKCNQFQKQAQSYHTQLNGKKQSIEDSSPEIPRLVCEPDSTCETSERDEFIIEKLKSAVSEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKLGESQSTQENKKRLELSYSSSIKETEKKRKELFSVTPDQPDHEKELNKIRSHLYQEEEYHSSEQERMRNEISDLTQELHQKEITISTVMKKAALLERQLKMELEIKEKMLSKQQMLDTRYKAVRTENTHLKGMMGDLDPGRYMTSGITDIKSVDFTNREHSRHTSINKLEYENERLRNDLAKLHASGKSTWANVNTYEEAGRFNHDREPNRSTTPPLPSSPFQTKEITSPLVSDEEVFPMSPPDISFPASLATQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYTKLKQDRHI", "length": 605, "header": "tr|F1MMN4-1|F1MMN4_BOVIN Isoform 1 of Deuterosome assembly protein 1 OS=Bos taurus OX=9913 GN=DEUP1 PE=3 SV=5 CANONICAL=F1MMN4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2E4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2E4/entry", "sequence": { "sequence": "MQQFLDMENQTHNTLGASPCEAELQELMEQIDIMVNNKKLDWERKMRALETRLDLRDQELANAQTCLEQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQTLKAQFSKLTNSFEKLRLHQLKQNKFRRKEVPHLKEEMPFELNSLNQKLEEFRAKSREWDKQEILYQTHLVSLDAQQKILSEKCNQFQKQAQSYHTQLNGKKQSIEDSSPEIPRLVCEPDSTCETSERDEFIIEKLKSAVSEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKLGESQSTQENKKRLELSYSSSIKETEKKRKELFSVTPDQPDHEKELNKIRSHLYQEEEYHSSEQERMRNEISDLTQELHQKEITISTVMKKAALLERQLKMELEIKEKMLSKQQMLDTRYKAVRTENTHLKGMMGDLDPGRYMTSGITDIKSVDFTNREHSRHTSINKLEYENERLRNDLAKLHASGKSTWANVNTYEEAGRFNHDREPNRSTTPPLPSSPFQTKEITSPLVSDEEVFPMSPPDISFPASLATQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYTKLKQDRHI", "length": 603, "header": "tr|A0AAA9S2E4-1|F1MMN4_BOVIN Computationally mapped isoform of Deuterosome assembly protein 1 OS=Bos taurus OX=9913 GN=DEUP1 PE=3 SV=1 CANONICAL=F1MMN4-1" }, "locus": { "chromosome": "29", "start_pos": 1548786, "end_pos": 1403627, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116978.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116978.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080079.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080079.1" } ] } }, { "isoform_ac": "A0AAA9S7S6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7S6/entry", "sequence": { "sequence": "MQQFLDMENQTHNTLGASPCEAELQELMEQIDIMVNNKKLDWERKMRALETRLDLRDQELANAQTCLEQKGQEFSKLTNSFEKLRLHQLKQNKFRRKEVPHLKEEMPFELNSLNQKLEEFRAKSREWDKQEILYQTHLVSLDAQQKILSEKCNQFQKQAQSYHTQLNGKKQSIEDSSPEIPRLVCEPDSTCETSERDEFIIEKLKSAVSEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKLGESQSTQENKKRLELSYSSSIKETEKKRKELFSVTPDQPDHEKELNKIRSHLYQEEEYHSSEQERMRNEISDLTQELHQKEITISTVMKKAALLERQLKMELEIKEKMLSKQQMLDTRYKAVRTENTHLKGMMGDLDPGRYMTSGITDIKSVDFTNREHSRHTSINKLEYENERLRNDLAKLHASGKSTWANVNTYEEAGRFNHDREPNRSTTPPLPSSPFQTKEITSPLVSDEEVFPMSPPDISFPASLATQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYTKLKQDRHI", "length": 571, "header": "tr|A0AAA9S7S6-1|F1MMN4_BOVIN Computationally mapped isoform of Deuterosome assembly protein 1 OS=Bos taurus OX=9913 GN=DEUP1 PE=3 SV=1 CANONICAL=F1MMN4-1" }, "locus": { "chromosome": "29", "start_pos": 1548786, "end_pos": 1403627, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118480.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118480.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081291.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081291.1" } ] } }, { "isoform_ac": "A0AAA9SLS0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS0/entry", "sequence": { "sequence": "MQQFLDMENQTHNTLGASPCEAELQELMEQIDIMVNNKKLDWERKMRALETRLDLRDQELANAQTCLEQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQTLKAQFSKLTNSFEKLRLHQLKQNKFRRKEVPHLKEEMPFELNSLNQKLEEFRAKSREWDKQEILYQTHLVSLDAQQKILSEKCNQFQKQAQSYHTQLNGKKQSIEDSSPEIPRLVCEPDSTCETSERDEFIIEKLKSAVSEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKLGESQSTQENKKRLELSYSSSIKETEKKRKELFSVTPDQPDHEKELNKIRSHLYQEEEYHSSEQERMRNEISDLTQELHQKEITISTVMKKAALLERQLKMELEIKEKMLSKQQMLDTRYKAVRTENTHLKGMMGDLDPGRYMTSGITDIKSVDFTNREHSRHTSINKLEYENERLRNDLAKLHASGKSTWANVNTYEEAGRFNHDREPNRSTTPPLPSSPFQTKEITSPLVSDEEVFPMGELQPFPASPGDSPRPTVSPRYILPGFFGHAAFPSGGGEASKRT", "length": 589, "header": "tr|A0AAA9SLS0-1|F1MMN4_BOVIN Computationally mapped isoform of Deuterosome assembly protein 1 OS=Bos taurus OX=9913 GN=DEUP1 PE=3 SV=1 CANONICAL=F1MMN4-1" }, "locus": { "chromosome": "29", "start_pos": 1548786, "end_pos": 1403721, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095688.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095688.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083649.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083649.1" } ] } }, { "isoform_ac": "A0AAA9SN18-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SN18/entry", "sequence": { "sequence": "MQQFLDMENQTHNTLGASPCEAELQELMEQIDIMVNNKKLDWERKMRALETRLDLRDQELANAQTCLEQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQTLKAQFSKLTNSFEKLRLHQLKQNKFRRKEVPHLKEEMPFELNSLNQKLEKQAQSYHTQLNGKKQSIEDSSPEIPRLVCEPDSTCETSERDEFIIEKLKSAVSEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKLGESQSTQENKKRLELSYSSSIKETEKKRKELFSVTPDQPDHEKELNKIRSHLYQEEEYHSSEQERMRNEISDLTQELHQKEITISTVMKKAALLERQLKMELEIKEKMLSKQQMLDTRYKAVRTENTHLKGMMGDLDPGRYMTSGITDIKSVDFTNREHSRHTSINKLEYENERLRNDLAKLHASGKSTWANVNTYEEAGRFNHDREPNRSTTPPLPSSPFQTKEITSPLVSDEEVFPMSPPDISFPASLATQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYTKLKQDRHI", "length": 565, "header": "tr|A0AAA9SN18-1|F1MMN4_BOVIN Computationally mapped isoform of Deuterosome assembly protein 1 OS=Bos taurus OX=9913 GN=DEUP1 PE=3 SV=1 CANONICAL=F1MMN4-1" }, "locus": { "chromosome": "29", "start_pos": 1548786, "end_pos": 1403627, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113980.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113980.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086711.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086711.1" } ] } }, { "isoform_ac": "F1MMN4-1", "url": "https://www.uniprot.org/uniprotkb/F1MMN4/entry", "sequence": { "sequence": "MPVEFNVLLRIFASVFTRASPCEAELQELMEQIDIMVNNKKLDWERKMRALETRLDLRDQELANAQTCLEQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQTLKAQFSKLTNSFEKLRLHQLKQNKFRRKEVPHLKEEMPFELNSLNQKLEEFRAKSREWDKQEILYQTHLVSLDAQQKILSEKCNQFQKQAQSYHTQLNGKKQSIEDSSPEIPRLVCEPDSTCETSERDEFIIEKLKSAVSEIALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKLGESQSTQENKKRLELSYSSSIKETEKKRKELFSVTPDQPDHEKELNKIRSHLYQEEEYHSSEQERMRNEISDLTQELHQKEITISTVMKKAALLERQLKMELEIKEKMLSKQQMLDTRYKAVRTENTHLKGMMGDLDPGRYMTSGITDIKSVDFTNREHSRHTSINKLEYENERLRNDLAKLHASGKSTWANVNTYEEAGRFNHDREPNRSTTPPLPSSPFQTKEITSPLVSDEEVFPMSPPDISFPASLATQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYTKLKQDRHI", "length": 605, "header": "tr|F1MMN4-1|F1MMN4_BOVIN Isoform 1 of Deuterosome assembly protein 1 OS=Bos taurus OX=9913 GN=DEUP1 PE=3 SV=5 CANONICAL=F1MMN4-1" }, "locus": { "chromosome": "29", "start_pos": 1529275, "end_pos": 1403627, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049593.6", "url": "https://www.ensembl.org/id/ENSBTAT00000049593.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046462.6", "url": "https://www.ensembl.org/id/ENSBTAP00000046462.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:537776", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537776", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MMN4", "url": "https://www.uniprot.org/uniprotkb/F1MMN4" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "F1MMN4", "url": "https://www.uniprot.org/uniprotkb/F1MMN4" } ], "pmid": "" }, { "name": "deuterosome", "id": "GO:0098536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098536", "evidence": [ { "database": "UniProtKB", "id": "F1MMN4", "url": "https://www.uniprot.org/uniprotkb/F1MMN4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell projection organization", "id": "GO:0030030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "database": "UniProtKB", "id": "F1MMN4", "url": "https://www.uniprot.org/uniprotkb/F1MMN4" } ], "pmid": "" }, { "name": "centriole replication", "id": "GO:0007099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007099", "evidence": [ { "database": "UniProtKB", "id": "F1MMN4", "url": "https://www.uniprot.org/uniprotkb/F1MMN4" } ], "pmid": "" }, { "name": "de novo centriole assembly involved in multi-ciliated epithelial cell differentiation", "id": "GO:0098535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098535", "evidence": [ { "database": "UniProtKB", "id": "F1MMN4", "url": "https://www.uniprot.org/uniprotkb/F1MMN4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1MMN4", "url": "https://www.uniprot.org/uniprotkb/F1MMN4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 517, "end_pos": 519, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MMN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMN4" }, { "id": "PF25771", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25771" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CEP63/Deup1 CEP152 binding coiled coil", "eco_id": "ECO_0000259", "start_pos": 562, "end_pos": 596, "start_aa": "His", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MMN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMN4" }, { "id": "PF17045", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17045" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CEP63/Deup1 N-terminal", "eco_id": "ECO_0000259", "start_pos": 20, "end_pos": 288, "start_aa": "Ser", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 517, "end_pos": 519 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"F1MLS5-1", "uniprot_ac": "F1MLS5", "uniprot_id": "F1MLS5_BOVIN", "mass": { "chemical_mass": 83265.0, "monoisotopic_mass": 83265.0 }, "refseq": { "ac": "XP_005225328", "name": "E3 ubiquitin-protein ligase SMURF1 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225328" }, "gene_names": [ { "name": "SMURF1", "type": "recommended", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] }, { "name": "SMURF1", "type": "synonym", "evidence": [ { "id": "XP_005225328", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225328" } ] } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase", "type": "recommended", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.26", "type": "synonym", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5/entry#names_and_taxonomy" } ] }, { "name": "E3 ubiquitin-protein ligase SMURF1 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_005225328", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225328" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SMURF1", "url": "https://www.uniprot.org/uniprotkb/F1MLS5", "locus": { "chromosome": "25", "start_pos": 37260641, "end_pos": 37170849, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007118", "url": "https://www.ensembl.org/id/ENSBTAG00000007118" } ] } } ], "crossref": [ { "id": "F1MLS5", "url": "https://alphafold.ebi.ac.uk/entry/F1MLS5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007118", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007118", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00078", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00078", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08382", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08382", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513902", "url": "https://www.ncbi.nlm.nih.gov/gene/513902", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024928", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024928", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:513902", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513902", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QWDRPRH", "url": "https://omabrowser.org/oma/group/QWDRPRH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MLS5", "url": "https://www.orthodb.org/?gene=F1MLS5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11254", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11254", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11254:SF293", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11254:SF293", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00397", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00397", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00632", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00632", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-201451", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201451", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2173791", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173791", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4608870", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4608870", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5632684", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5632684", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8941858", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8941858", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005225328", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225328", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S4G8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4G8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLS5-1", "url": "https://www.uniprot.org/uniprotkb/F1MLS5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLESEGTVYEDSGPGRPLSCFMEEPAPYTDGPGAAAGGGTCRFVESPSQDQRLQAQRLRNPEVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMTHQCQLKEPSQPPPPPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLDDWKSNTRLKHCGADSNVVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE", "length": 731, "header": "tr|F1MLS5-1|F1MLS5_BOVIN Isoform 1 of E3 ubiquitin-protein ligase OS=Bos taurus OX=9913 GN=SMURF1 PE=4 SV=3 CANONICAL=F1MLS5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4G8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4G8/entry", "sequence": { "sequence": "MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLESEGTVYEDSGPGRPLSCFMEEPAPYTDGPGAAAGGGTCRFVESPSQDQRLQAQRLRNPEVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPWGTTPGGDGAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMTHQCQLKEPSQPPPPPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLDDWKSNTRLKHCGADSNVVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE", "length": 757, "header": "tr|A0AAA9S4G8-1|F1MLS5_BOVIN Computationally mapped isoform of E3 ubiquitin-protein ligase OS=Bos taurus OX=9913 GN=SMURF1 PE=4 SV=1 CANONICAL=F1MLS5-1" }, "locus": { "chromosome": "25", "start_pos": 37259637, "end_pos": 37171048, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089199.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089199.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080830.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080830.1" } ] } }, { "isoform_ac": "F1MLS5-1", "url": "https://www.uniprot.org/uniprotkb/F1MLS5/entry", "sequence": { "sequence": "MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLESEGTVYEDSGPGRPLSCFMEEPAPYTDGPGAAAGGGTCRFVESPSQDQRLQAQRLRNPEVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMTHQCQLKEPSQPPPPPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLDDWKSNTRLKHCGADSNVVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE", "length": 731, "header": "tr|F1MLS5-1|F1MLS5_BOVIN Isoform 1 of E3 ubiquitin-protein ligase OS=Bos taurus OX=9913 GN=SMURF1 PE=4 SV=3 CANONICAL=F1MLS5-1" }, "locus": { "chromosome": "25", "start_pos": 37259637, "end_pos": 37171048, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043725.6", "url": "https://www.ensembl.org/id/ENSBTAT00000043725.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041274.4", "url": "https://www.ensembl.org/id/ENSBTAP00000041274.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:513902", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513902", "resource": "KEGG Pathway" }, { "id": "R-BTA-201451", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201451", "resource": "Reactome", "description": "Signaling by BMP" }, { "id": "R-BTA-2173791", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173791", "resource": "Reactome", "description": "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" }, { "id": "R-BTA-4608870", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4608870", "resource": "Reactome", "description": "Asymmetric localization of PCP proteins" }, { "id": "R-BTA-5632684", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5632684", "resource": "Reactome", "description": "Hedgehog 'on' state" }, { "id": "R-BTA-8941858", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8941858", "resource": "Reactome", "description": "Regulation of RUNX3 expression and activity" }, { "id": "R-BTA-983168", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K612-1", "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "Smurf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGGGGSVVDCRGLLENEGTVYEDSGPGRPLSCLMEEPAPYTDGTGAAAGGGNCRFVESPSQDQRLLVQRLRNPEVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPLGTIPGGDEAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLQLPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE", "length": 757 }, "evidence": [ { "id": "F1MLS5", "url": "https://omabrowser.org/oma/group/F1MLS5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A5G2QY82-1", "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "SMURF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAVSRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRLGTGGPVVDCRGLLDNEGTVYEDSGPGRPLSCFMEEPAPYTDGPGAAAGGGNCRFVESPSQDQRVQAQRLRNPEVRGPLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRVPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQSLPLPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLDDWKSNTRLKHCGADSNVVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE", "length": 731 }, "evidence": [ { "id": "F1MLS5", "url": "https://omabrowser.org/oma/group/F1MLS5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9CUN6-1", "protein_name": "E3 ubiquitin-protein ligase SMURF1", "gene_name": "Smurf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGGGGSVVDCRGLLENEGTVYEDSGPGRPLSCLMEEPAPYTDGTGAAAGGGNCRFVESPSQDQRLLVQRLRNPEVRGPLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLQLPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE", "length": 731 }, "evidence": [ { "id": "F1MLS5", "url": "https://omabrowser.org/oma/group/F1MLS5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9HCE7-1", "protein_name": "E3 ubiquitin-protein ligase SMURF1", "gene_name": "SMURF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE", "length": 757 }, "evidence": [ { "id": "F1MLS5", "url": "https://omabrowser.org/oma/group/F1MLS5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9V853-1", "protein_name": "E3 ubiquitin-protein ligase Smurf1", "gene_name": "Smurf", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNKLDYPRRNGTHKVRITILCARNLARKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLGIGDAITITVWNQRKIHKGSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIISLLSKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEILSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE", "length": 1061 }, "evidence": [ { "id": "F1MLS5", "url": "https://omabrowser.org/oma/group/F1MLS5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 17, "go_terms": [ { "name": "positive regulation of dendrite extension", "id": "GO:1903861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903861", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "BMP signaling pathway", "id": "GO:0030509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030509", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "negative regulation of BMP signaling pathway", "id": "GO:0030514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "negative regulation of activin receptor signaling pathway", "id": "GO:0032926", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032926", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "ectoderm development", "id": "GO:0007398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007398", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "negative regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030512", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "protein export from nucleus", "id": "GO:0006611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006611", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "engulfment of target by autophagosome", "id": "GO:0061736", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061736", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "substrate localization to autophagosome", "id": "GO:0061753", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061753", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "protein targeting to vacuole involved in autophagy", "id": "GO:0071211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071211", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "receptor catabolic process", "id": "GO:0032801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032801", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "positive regulation of ubiquitin-dependent protein catabolic process", "id": "GO:2000060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000060", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "transforming growth factor beta receptor binding", "id": "GO:0005160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005160", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "R-SMAD binding", "id": "GO:0070412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070412", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "I-SMAD binding", "id": "GO:0070411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070411", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "activin receptor binding", "id": "GO:0070697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070697", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" }, { "name": "SMAD binding", "id": "GO:0046332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046332", "evidence": [ { "database": "UniProtKB", "id": "F1MLS5", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-201445", "name": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TWH7-1", "F1MLS5-1" ], "evidence": [ { "id": "R-BTA-201445", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201445" } ] }, { "id": "R-BTA-201821", "name": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytoplasmic side of plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q28043-1", "F1MCE7-1", "A0AAA9TWH7-1", "F1MLS5-1", "A0A3Q1LP90-1" ], "evidence": [ { "id": "R-BTA-201821", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201821" } ] }, { "id": "R-BTA-2160931", "name": "Disassembly of tight junctions", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cell junction", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61585-1", "F1MLS5-1", "G3MZV8-1", "O46680-1" ], "evidence": [ { "id": "R-BTA-2160931", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2160931" } ] }, { "id": "R-BTA-2160932", "name": "SMURF1 binds phosphorylated PARD6A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cell junction, cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61585-1", "F1MLS5-1", "G3MZV8-1", "O46680-1" ], "evidence": [ { "id": "R-BTA-2160932", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2160932" } ] }, { "id": "R-BTA-2160935", "name": "SMURF1 ubiquitinates RHOA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cell junction, cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61585-1", "F1MLS5-1", "G3MZV8-1", "O46680-1" ], "evidence": [ { "id": "R-BTA-2160935", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2160935" } ] }, { "id": "R-BTA-4608852", "name": "SMURF1/2 ubiquitinates PRICKLE1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-BTA-4608816" ], "output_participant_list": [ "R-BTA-4608820" ], "enzyme_list": [ "A0AAA9TWH7-1", "F1MLS5-1" ], "evidence": [ { "id": "R-BTA-4608852", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4608852" } ] }, { "id": "R-BTA-4608854", "name": "SMURF1/2 are recruited to the DVL2:PARD6A complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TWH7-1", "F1MLS5-1" ], "evidence": [ { "id": "R-BTA-4608854", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4608854" } ] }, { "id": "R-BTA-5635865", "name": "SMURF1/2 dissociates from ub-PTCH1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "ciliary membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9TWH7-1", "F1MLS5-1" ], "evidence": [ { "id": "R-BTA-5635865", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5635865" } ] }, { "id": "R-BTA-8952419", "name": "SMURFs ubiquitinate RUNX3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-BTA-8865393" ], "output_participant_list": [ "R-BTA-8952417" ], "enzyme_list": [ "A0AAA9TWH7-1", "F1MLS5-1", "E1B8D6-1" ], "evidence": [ { "id": "R-BTA-8952419", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8952419" } ] }, { "id": "R-BTA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983140" } ] }, { "id": "R-BTA-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1A4I9-1", "E1BJS7-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q1JQA1-1", "Q29RQ5-1", "Q32LN5-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0AAA9RXI4-1", "Q4U5R4-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983147" } ] }, { "id": "R-BTA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983156" } ] }, { "id": "R-BTA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61085-1", "A1A4I9-1", "E1BJS7-1", "A3KN22-1", "A6H795-1", "E1B7Q7-1", "E1BH71-1", "F1MM41-1", "Q32PA5-1", "Q3MHP1-1", "Q5E9J6-1", "Q7YRV4-1", "A0A3Q1N3G7-1", "A5PJC4-1", "A0AAF6DMH9-1", "E1BCU1-1", "F1MJS5-1", "F1MYL0-1", "F1N6G5-1", "Q0P5K3-1", "Q17QG5-1", "Q1JQA1-1", "Q1RMW1-1", "Q1RMX2-1", "Q29RQ5-1", "Q2T9X7-1", "Q2TA03-1", "Q2TA10-1", "Q32LN1-1", "Q32LN5-1", "Q32P99-1", "F1MEX6-1", "F1MTS8-1", "F1N495-1", "F1N645-1", "Q0II22-1", "Q1RML1-1", "A0JN74-1", "A5PKG6-1", "E1B782-1", "E1B7G3-1", "E1B8R6-1", "E1BCW1-1", "E1BIW0-1", "E1BNY9-1", "F1MBM6-1", "A0A3Q1MLB6-1", "A0A3Q1MLH2-1", "E1BAV2-1", "F1N1X8-1", "F1N3I3-1", "F1N5G3-1", "A0AAA9TKS8-1", "F1N703-1", "F1N7A0-1", "A0AAA9TWH7-1", "A0A3Q1LV49-1", "A0AAA9S100-1", "A0AAA9RZ14-1", "F1MLS5-1", "F1MWS4-1", "A5D7F8-1", "F1MJ10-1", "A0A3Q1MAR8-1", "A0AAA9RXI4-1", "Q4U5R4-1", "Q32L27-1", "E1B7D3-1", "E1BBN5-1", "E1BBY2-1", "A0AAA9RXX2-1", "E1BID7-1", "A0ABI0NWC8-1", "E1BIP5-1", "E1BL26-1", "E1BNQ6-1" ], "evidence": [ { "id": "R-BTA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983157" } ] } ], "reaction_participants": [ { "participant_id": "R-BTA-4608816", "participant_name": "PRICKLE1 [cytosol]", "crossref": [ { "id": "A5D7T1", "database": "UniProt", "url": "" }, { "id": "NP_001415229.1", "database": "RefSeq", "url": "" }, { "id": "NP_001096004.1", "database": "RefSeq", "url": "" }, { "id": "NP_001415230.1", "database": "RefSeq", "url": "" }, { "id": "33315", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-4608820", "participant_name": "PRICKLE1 [cytosol]", "crossref": [ { "id": "NP_001415230.1", "database": "RefSeq", "url": "" }, { "id": "NP_001415229.1", "database": "RefSeq", "url": "" }, { "id": "A5D7T1", "database": "UniProt", "url": "" }, { "id": "NP_001096004.1", "database": "RefSeq", "url": "" }, { "id": "33315", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-8865393", "participant_name": "RUNX3 [nucleoplasm]", "crossref": [ { "id": "A0A3Q1MYL2", "database": "UniProt", "url": "" }, { "id": "ENSBTAG00000050474", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAP00000061160", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAT00000070567", "database": "ENSEMBL", "url": "" }, { "id": "34221", "database": "VGNC", "url": "" } ] }, { "participant_id": "R-BTA-8952417", "participant_name": "PolyUb-RUNX3 [nucleoplasm]", "crossref": [ { "id": "ENSBTAP00000061160", "database": "ENSEMBL", "url": "" }, { "id": "34221", "database": "VGNC", "url": "" }, { "id": "A0A3Q1MYL2", "database": "UniProt", "url": "" }, { "id": "ENSBTAT00000070567", "database": "ENSEMBL", "url": "" }, { "id": "ENSBTAG00000050474", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LP90", "gene_name": "BMPR2", "activity": [ { "ec_number": "2.7.11.30", "activity": "L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LP90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP90" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "A0A3Q1LP90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LP90" } ] } ] }, { "uniprot_ac": "A0A3Q1LV49", "gene_name": "LOC512869", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1LV49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LV49" } ] } ] }, { "uniprot_ac": "A0A3Q1MAR8", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MAR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAR8" } ] } ] }, { "uniprot_ac": "A0A3Q1MLB6", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0A3Q1MLB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLB6" } ] } ] }, { "uniprot_ac": "A0A3Q1MLH2", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A3Q1MLH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLH2" } ] } ] }, { "uniprot_ac": "A0A3Q1N3G7", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A3Q1N3G7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N3G7" } ] } ] }, { "uniprot_ac": "A0AAA9RXI4", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXI4" } ] } ] }, { "uniprot_ac": "A0AAA9RXX2", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9RXX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXX2" } ] } ] }, { "uniprot_ac": "A0AAA9RZ14", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9RZ14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZ14" } ] } ] }, { "uniprot_ac": "A0AAA9S100", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAA9S100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S100" } ] } ] }, { "uniprot_ac": "A0AAA9TKS8", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0AAA9TKS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKS8" } ] } ] }, { "uniprot_ac": "A0AAA9TWH7", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0AAA9TWH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWH7" } ] } ] }, { "uniprot_ac": "A0AAF6DMH9", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0AAF6DMH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH9" } ] } ] }, { "uniprot_ac": "A0ABI0NWC8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A0ABI0NWC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NWC8" } ] } ] }, { "uniprot_ac": "A0JN74", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0JN74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JN74" } ] } ] }, { "uniprot_ac": "A1A4I9", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "A1A4I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I9" } ] } ] }, { "uniprot_ac": "A3KN22", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "A3KN22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A3KN22" } ] } ] }, { "uniprot_ac": "A5D7F8", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5D7F8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7F8" } ] } ] }, { "uniprot_ac": "A5PJC4", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A5PJC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJC4" } ] } ] }, { "uniprot_ac": "A5PKG6", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5PKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKG6" } ] } ] }, { "uniprot_ac": "A6H795", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "A6H795", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H795" } ] } ] }, { "uniprot_ac": "E1B782", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B782" } ] } ] }, { "uniprot_ac": "E1B7D3", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7D3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7D3" } ] } ] }, { "uniprot_ac": "E1B7G3", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1B7G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7G3" } ] } ] }, { "uniprot_ac": "E1B7Q7", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1B7Q7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7Q7" } ] } ] }, { "uniprot_ac": "E1B8D6", "gene_name": "EP300", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "E1B8D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D6" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "E1B8D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8D6" } ] } ] }, { "uniprot_ac": "E1B8R6", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1B8R6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8R6" } ] } ] }, { "uniprot_ac": "E1BAV2", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAV2" } ] } ] }, { "uniprot_ac": "E1BBN5", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBN5" } ] } ] }, { "uniprot_ac": "E1BBY2", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BBY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBY2" } ] } ] }, { "uniprot_ac": "E1BCU1", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BCU1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU1" } ] } ] }, { "uniprot_ac": "E1BCW1", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BCW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCW1" } ] } ] }, { "uniprot_ac": "E1BH71", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BH71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH71" } ] } ] }, { "uniprot_ac": "E1BID7", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BID7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BID7" } ] } ] }, { "uniprot_ac": "E1BIP5", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "E1BIP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIP5" } ] } ] }, { "uniprot_ac": "E1BIW0", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BIW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIW0" } ] } ] }, { "uniprot_ac": "E1BJS7", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJS7" } ] } ] }, { "uniprot_ac": "E1BL26", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BL26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL26" } ] } ] }, { "uniprot_ac": "E1BNQ6", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BNQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNQ6" } ] } ] }, { "uniprot_ac": "E1BNY9", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "E1BNY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNY9" } ] } ] }, { "uniprot_ac": "F1MBM6", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MBM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBM6" } ] } ] }, { "uniprot_ac": "F1MCE7", "gene_name": "BMPR1A", "activity": [ { "ec_number": "2.7.11.30", "activity": "L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+).", "evidence": [ { "id": "F1MCE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCE7" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "F1MCE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MCE7" } ] } ] }, { "uniprot_ac": "F1MEX6", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "F1MEX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEX6" } ] } ] }, { "uniprot_ac": "F1MJ10", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJ10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ10" } ] } ] }, { "uniprot_ac": "F1MJS5", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MJS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS5" } ] } ] }, { "uniprot_ac": "F1MLS5", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" } ] } ] }, { "uniprot_ac": "F1MM41", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MM41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM41" } ] } ] }, { "uniprot_ac": "F1MTS8", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MTS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS8" } ] } ] }, { "uniprot_ac": "F1MWS4", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MWS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWS4" } ] } ] }, { "uniprot_ac": "F1MYL0", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MYL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYL0" } ] } ] }, { "uniprot_ac": "F1N1X8", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "F1N1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1X8" } ] } ] }, { "uniprot_ac": "F1N3I3", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "F1N3I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3I3" } ] } ] }, { "uniprot_ac": "F1N495", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N495" } ] } ] }, { "uniprot_ac": "F1N5G3", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1N5G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5G3" } ] } ] }, { "uniprot_ac": "F1N645", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N645", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N645" } ] } ] }, { "uniprot_ac": "F1N6G5", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N6G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6G5" } ] } ] }, { "uniprot_ac": "F1N703", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N703", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N703" } ] } ] }, { "uniprot_ac": "F1N7A0", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1N7A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N7A0" } ] } ] }, { "uniprot_ac": "G3MZV8", "gene_name": "TGFBR2", "activity": [ { "ec_number": "2.7.11.30", "activity": "L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+).", "evidence": [ { "id": "G3MZV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZV8" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "G3MZV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZV8" } ] } ] }, { "uniprot_ac": "O46680", "gene_name": "TGFBR1", "activity": [ { "ec_number": "2.7.11.30", "activity": "L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+).", "evidence": [ { "id": "O46680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46680" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "O46680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46680" } ] } ] }, { "uniprot_ac": "P61085", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61085" } ] } ] }, { "uniprot_ac": "P61585", "gene_name": "RHOA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P61585", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P61585" } ] } ] }, { "uniprot_ac": "Q0II22", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q0II22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0II22" } ] } ] }, { "uniprot_ac": "Q0P5K3", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q0P5K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0P5K3" } ] } ] }, { "uniprot_ac": "Q17QG5", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q17QG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QG5" } ] } ] }, { "uniprot_ac": "Q1JQA1", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q1JQA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JQA1" } ] } ] }, { "uniprot_ac": "Q1RML1", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RML1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RML1" } ] } ] }, { "uniprot_ac": "Q1RMW1", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q1RMW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMW1" } ] } ] }, { "uniprot_ac": "Q1RMX2", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q1RMX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMX2" } ] } ] }, { "uniprot_ac": "Q28043", "gene_name": "ACVR2A", "activity": [ { "ec_number": "2.7.11.30", "activity": "L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+).", "evidence": [ { "id": "Q28043", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28043" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q28043", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28043" } ] } ] }, { "uniprot_ac": "Q29RQ5", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q29RQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q29RQ5" } ] } ] }, { "uniprot_ac": "Q2T9X7", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2T9X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X7" } ] } ] }, { "uniprot_ac": "Q2TA03", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA03" } ] } ] }, { "uniprot_ac": "Q2TA10", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q2TA10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA10" } ] } ] }, { "uniprot_ac": "Q32L27", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32L27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L27" } ] } ] }, { "uniprot_ac": "Q32LN1", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32LN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN1" } ] } ] }, { "uniprot_ac": "Q32LN5", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q32LN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32LN5" } ] } ] }, { "uniprot_ac": "Q32P99", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32P99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32P99" } ] } ] }, { "uniprot_ac": "Q32PA5", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q32PA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PA5" } ] } ] }, { "uniprot_ac": "Q3MHP1", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3MHP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHP1" } ] } ] }, { "uniprot_ac": "Q4U5R4", "gene_name": "RNF114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q4U5R4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4U5R4" } ] } ] }, { "uniprot_ac": "Q5E9J6", "gene_name": "RNF34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5E9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9J6" } ] } ] }, { "uniprot_ac": "Q7YRV4", "gene_name": "TRIM21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7YRV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRV4" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MLS5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 731, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MLS5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MLS5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 120, "start_aa": "Met", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" }, { "id": "PS50237", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50237" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HECT", "eco_id": "ECO_0000259", "start_pos": 394, "end_pos": 731, "start_aa": "Arg", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLS5" }, { "id": "PS50020", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50020" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "WW", "eco_id": "ECO_0000259", "start_pos": 234, "end_pos": 267, "start_aa": "Pro", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.3.2.26", "ec_name": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "2.3.2.26", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.2.26" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 303, "end_pos": 305 }, { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MST2-1", "uniprot_ac": "F1MST2", "uniprot_id": "F1MST2_BOVIN", "mass": { "chemical_mass": 61458.0, "monoisotopic_mass": 61458.0 }, "refseq": {}, "gene_names": [ { "name": "LOC618463", "type": "recommended", "evidence": [ { "id": "F1MST2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MST2" } ] } ], "protein_names": [ { "name": "Ig-like domain-containing protein", "type": "recommended", "evidence": [ { "id": "F1MST2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MST2/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MST2", "url": "https://www.uniprot.org/uniprotkb/F1MST2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC618463", "url": "https://www.uniprot.org/uniprotkb/F1MST2", "locus": {} } ], "crossref": [ { "id": "F1MST2", "url": "https://alphafold.ebi.ac.uk/entry/F1MST2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000037537", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037537", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "618463", "url": "https://www.ncbi.nlm.nih.gov/gene/618463", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618463", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618463", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "SITCEMP", "url": "https://omabrowser.org/oma/group/SITCEMP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MST2", "url": "https://www.orthodb.org/?gene=F1MST2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12035", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12035", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12035:SF139", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12035:SF139", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07686", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF27822", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27822", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-198933", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198933", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S4W2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4W2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S4W2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4W2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MST2", "url": "https://www.uniprot.org/uniprotkb/F1MST2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MST2-1", "url": "https://www.uniprot.org/uniprotkb/F1MST2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLLPLLLSLLWVGEWGWGSTNPHFPTGSLAQDLRYQLDVPRSVSVQEGLCVHVACSVYYPREGWKDSDPAHSYWFRERTDSPGDPAVATNNPEREVLSETQGRFLLVGDPWTKDCSLDIRDAQRTDTGTYIFRVERGPTVRYSYKWHPLSVRVMALTDTPDIHVQGTLASGRPTNLTCAVPWACERGTPPTFSWTGVALTSPNPESPHSSVLTLTPSPQDHGTNLTCRVTFPGAGVSTEATIRLNVSYAPQELTIRVYQKEGTGPETLGKSQSLSVQEGQSLRLDCVPDSNPPAMISWTRESLTLSPSNSLNPGVLELPRVELRDQGLYVCQAQHPLGSKKAFLNLVVRTPPQLLGPSCSQEDEGLSCSCSTRAWPAPSLHWRLGEGLLEGNFSNASFEIASSSAGPWANSSLSLREGLSSDLRLSCEAQNAHGKQIVKILLLPGKPGPRTGVVQGAIGGAGITALLALCLIFVVKIYRKKSVERASSQDGDCPASRPASRGHYNESWSDSPSDYQTPASAASTSEKEQELYYANLSFHRPRTHNFQVWDTTEYSEIKIGK", "length": 562, "header": "tr|F1MST2-1|F1MST2_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN=LOC618463 PE=3 SV=3 CANONICAL=F1MST2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S4W2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4W2/entry", "sequence": { "sequence": "MLLLPLLLSLLWVGWKDSDPAHSYWFRERTDSPGDPAVATNNPEREVLSETQGRFLLVGDPWTKDCSLDIRDAQRTDTGTYIFRVERGPTVRYSYKWHPLSVRVMALTDTPDIHVQGTLASGRPTNLTCAVPWACERGTPPTFSWTGVALTSPNPESPHSSVLTLTPSPQDHGTNLTCRVTFPGAGVSTEATIRLNVSYAPQELTIRVYQKEGTGPETLGKSQSLSVQEGQSLRLDCVPDSNPPAMISWTRESLTLSPSNSLNPGVLELPRVELRDQGLYVCQAQHPLGSKKAFLNLVVRTPPQLLGPSCSQEDEGLSCSCSTRAWPAPSLHWRLGEGLLEGNFSNASFEIASSSAGPWANSSLSLREGLSSDLRLSCEAQNAHGKQIVKILLLPGKPGPRTGVVQGAIGGAGITALLALCLIFVVKIYRKKSVERASSQDGDCPASRPASRGHYNESWSDSPSDYQTPASAASTSEKEQELYYANLSFHRPRTHNFQVWDTTEYSEIKIGK", "length": 512, "header": "tr|A0AAA9S4W2-1|F1MST2_BOVIN Computationally mapped isoform of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN=LOC618463 PE=3 SV=1 CANONICAL=F1MST2-1" }, "locus": { "chromosome": "18", "start_pos": 57142438, "end_pos": 57136252, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088565.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088565.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078268.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078268.1" } ] } }, { "isoform_ac": "F1MST2-1", "url": "https://www.uniprot.org/uniprotkb/F1MST2/entry", "sequence": { "sequence": "MLLLPLLLSLLWVGEWGWGSTNPHFPTGSLAQDLRYQLDVPRSVSVQEGLCVHVACSVYYPREGWKDSDPAHSYWFRERTDSPGDPAVATNNPEREVLSETQGRFLLVGDPWTKDCSLDIRDAQRTDTGTYIFRVERGPTVRYSYKWHPLSVRVMALTDTPDIHVQGTLASGRPTNLTCAVPWACERGTPPTFSWTGVALTSPNPESPHSSVLTLTPSPQDHGTNLTCRVTFPGAGVSTEATIRLNVSYAPQELTIRVYQKEGTGPETLGKSQSLSVQEGQSLRLDCVPDSNPPAMISWTRESLTLSPSNSLNPGVLELPRVELRDQGLYVCQAQHPLGSKKAFLNLVVRTPPQLLGPSCSQEDEGLSCSCSTRAWPAPSLHWRLGEGLLEGNFSNASFEIASSSAGPWANSSLSLREGLSSDLRLSCEAQNAHGKQIVKILLLPGKPGPRTGVVQGAIGGAGITALLALCLIFVVKIYRKKSVERASSQDGDCPASRPASRGHYNESWSDSPSDYQTPASAASTSEKEQELYYANLSFHRPRTHNFQVWDTTEYSEIKIGK", "length": 562, "header": "tr|F1MST2-1|F1MST2_BOVIN Isoform 1 of Ig-like domain-containing protein OS=Bos taurus OX=9913 GN=LOC618463 PE=3 SV=3 CANONICAL=F1MST2-1" }, "locus": { "chromosome": "18", "start_pos": 57142438, "end_pos": 57136252, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000031802.6", "url": "https://www.ensembl.org/id/ENSBTAT00000031802.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000031748.5", "url": "https://www.ensembl.org/id/ENSBTAP00000031748.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618463", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618463", "resource": "KEGG Pathway" }, { "id": "R-BTA-198933", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-198933", "resource": "Reactome", "description": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" } ], "orthologs": [ { "uniprot_canonical_ac": "A0ABK0M7S7-1", "protein_name": "Sialic acid binding Ig-like lectin 5", "gene_name": "Siglec5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRQFRSGGRLFLADFGSHDATQEKWKCLFSKGLDIADNLRVESSFLLCGSLAVENYELSLTESVTVQEGLCVFVPCQVKYPASGGSVFGYWFQDGANTNLNSPVATNDPHRPVQQETQGRFYLVGGIDTKNCSLDIRDARKSDTGKYFFRLDGSVKYSFRNRMLSVHVTALTKTPNLQVTSTLVSGTSTRVICSVLWACEQGTPPIFSWMSSALTSLGRRTILSSELNLTPRPQDNGTNLICQVTFPGAGVTVERTQQLSVTYAPQKLTIRVSWGDGTETKVLQSGASLQIQEGESLRLVCVADSNPSAMLSWKRQTQKNFRLSKGDELQLPRVELEDQGKYICQAKNSLGTQTASVSLSIRSLLQLLAPSCSWDSEGLHCSCSSRAWPAPSLGWRLGEGLLEGNSSNASFTVMSSSAGPWVNSSLSLSVEFSTDHRLSCEAWNDYGVQRATIVLVPGQGVSQADKSETSGGAVQGAIWGAGLMALLAVSFCLIFFIVKFLRKKSALEVAAMEGNHLAKNLVSTINSASMISSNIPLRYPIQDHLNESESQTQKEEPPLATAPDIPKDEPELHYASLSFQGPRPQQPKNTETIKSVYTEIKIHKR", "length": 605 }, "evidence": [ { "id": "F1MST2", "url": "https://omabrowser.org/oma/group/F1MST2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q920G3-1", "protein_name": "Sialic acid-binding Ig-like lectin 5", "gene_name": "Siglec5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRWAWLLPLLWAGCLATDGYSLSVTGSVTVQEGLCVFVACQVQYPNSKGPVFGYWFREGANIFSGSPVATNDPQRSVLKEAQGRFYLMGKENSHNCSLDIRDAQKIDTGTYFFRLDGSVKYSFQKSMLSVLVIALTEVPNIQVTSTLVSGNSTKLLCSVPWACEQGTPPIFSWMSSALTSLGHRTTLSSELNLTPRPQDNGTNLTCQVNLPGTGVTVERTQQLSVIYAPQKMTIRVSWGDDTGTKVLQSGASLQIQEGESLSLVCMADSNPPAVLSWERPTQKPFQLSTPAELQLPRAELEDQGKYICQAQNSQGAQTASVSLSIRSLLQLLGPSCSFEGQGLHCSCSSRAWPAPSLRWRLGEGVLEGNSSNGSFTVKSSSAGQWANSSLILSMEFSSNHRLSCEAWSDNRVQRATILLVSGPKVSQAGKSETSRGTVLGAIWGAGLMALLAVCLCLIFFTVKVLRKKSALKVAATKGNHLAKNPASTINSASITSSNIALGYPIQGHLNEPGSQTQKEQPPLATVPDTQKDEPELHYASLSFQGPMPPKPQNTEAMKSVYTEIKIHKC", "length": 569 }, "evidence": [ { "id": "F1MST2", "url": "https://omabrowser.org/oma/group/F1MST2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1MST2", "url": "https://www.uniprot.org/uniprotkb/F1MST2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MST2", "url": "https://www.uniprot.org/uniprotkb/F1MST2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MST2", "url": "https://www.uniprot.org/uniprotkb/F1MST2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "F1MST2", "url": "https://www.uniprot.org/uniprotkb/F1MST2" } ], "pmid": "" }, { "name": "sialic acid binding", "id": "GO:0033691", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033691", "evidence": [ { "database": "UniProtKB", "id": "F1MST2", "url": "https://www.uniprot.org/uniprotkb/F1MST2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 225, "end_pos": 227, "annotation": "n_glycosylation_sequon" }, { "start_pos": 246, "end_pos": 248, "annotation": "n_glycosylation_sequon" }, { "start_pos": 393, "end_pos": 395, "annotation": "n_glycosylation_sequon" }, { "start_pos": 396, "end_pos": 398, "annotation": "n_glycosylation_sequon" }, { "start_pos": 411, "end_pos": 413, "annotation": "n_glycosylation_sequon" }, { "start_pos": 506, "end_pos": 508, "annotation": "n_glycosylation_sequon" }, { "start_pos": 536, "end_pos": 538, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MST2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 562, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MST2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MST2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MST2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MST2" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 26, "end_pos": 144, "start_aa": "Pro", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 176, "end_pos": 178 }, { "start_pos": 225, "end_pos": 227 }, { "start_pos": 246, "end_pos": 248 }, { "start_pos": 393, "end_pos": 395 }, { "start_pos": 396, "end_pos": 398 }, { "start_pos": 411, "end_pos": 413 }, { "start_pos": 506, "end_pos": 508 }, { "start_pos": 536, "end_pos": 538 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MTX7-1", "uniprot_ac": "F1MTX7", "uniprot_id": "F1MTX7_BOVIN", "mass": { "chemical_mass": 57052.0, "monoisotopic_mass": 57052.0 }, "refseq": {}, "gene_names": [ { "name": "DARS1", "type": "recommended", "evidence": [ { "id": "F1MTX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTX7" } ] } ], "protein_names": [ { "name": "Aspartate--tRNA ligase, cytoplasmic", "type": "recommended", "evidence": [ { "id": "F1MTX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTX7/entry#names_and_taxonomy" } ] }, { "name": "6.1.1.12", "type": "synonym", "evidence": [ { "id": "F1MTX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTX7/entry#names_and_taxonomy" } ] }, { "name": "Aspartyl-tRNA synthetase", "type": "synonym", "evidence": [ { "id": "F1MTX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTX7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S6R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R3#function" }, { "database": "UniProtKB", "id": "ARBA00003170", "url": "https://www.uniprot.org/uniprotkb/ARBA00003170#function" }, { "database": "UniProtKB", "id": "A0A3Q1LXT8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXT8#function" }, { "database": "UniProtKB", "id": "F1MTX7", "url": "https://www.uniprot.org/uniprotkb/F1MTX7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MTX7", "url": "https://www.uniprot.org/uniprotkb/F1MTX7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DARS1", "url": "https://www.uniprot.org/uniprotkb/F1MTX7", "locus": { "chromosome": "2", "start_pos": 61461385, "end_pos": 61390819, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009949", "url": "https://www.ensembl.org/id/ENSBTAG00000009949" } ] } } ], "crossref": [ { "id": "F1MTX7", "url": "https://alphafold.ebi.ac.uk/entry/F1MTX7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009949", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009949", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00776", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00776", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04320", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04320", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510162", "url": "https://www.ncbi.nlm.nih.gov/gene/510162", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002312", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002312", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004523", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004523", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045864", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045864", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WVHEIRD", "url": "https://omabrowser.org/oma/group/WVHEIRD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR43450", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43450", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43450:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43450:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00152", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00152", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01336", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01336", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9856649", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9856649", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "19649", "url": "https://www.rhea-db.org/rhea/19649", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LXT8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXT8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXT8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6R3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6R3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTX7", "url": "https://www.uniprot.org/uniprotkb/F1MTX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTX7-1", "url": "https://www.uniprot.org/uniprotkb/F1MTX7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPSANASRRSQEKPREIMDAAEDYAKERYGVSSMIQSQEKPDRVLVRISDLTVQKAGEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISSAEPRLPLQLDDAVRPEVEGEEDGRATVNQDTRLDNRVIDLRTSTSQAIFRLQSGICHLFRETLTNKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQKRFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGIEMGDEEDLSTPNEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP", "length": 501, "header": "tr|F1MTX7-1|F1MTX7_BOVIN Isoform 1 of Aspartate--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=DARS1 PE=3 SV=1 CANONICAL=F1MTX7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXT8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXT8/entry", "sequence": { "sequence": "MTVFHVTALEKAVIFISFLLSNPSEDYAKERYGVSSMIQSQEKPDRVLVRISDLTVQKAGEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISSAEPRLPLQLDDAVRPEVEGEEDGRATVNQDTRLDNRVIDLRTSTSQAIFRLQSGICHLFRETLTNKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQKRFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGIEMGDEEDLSTPNEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP", "length": 504, "header": "tr|A0A3Q1LXT8-1|F1MTX7_BOVIN Computationally mapped isoform of Aspartate--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=DARS1 PE=3 SV=2 CANONICAL=F1MTX7-1" }, "locus": { "chromosome": "2", "start_pos": 61455352, "end_pos": 61391424, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068325.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068325.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065619.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065619.2" } ] } }, { "isoform_ac": "A0AAA9S6R3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6R3/entry", "sequence": { "sequence": "MPSANASRRSQEKPREIMDAAEDYAKERYGVSSMIQSQEKPDRVLVRISDLTVQKAGEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISSAEPRLPLQLDDAVRPEVEGEEDGRATVNQDTRLDNRVIDLRTSTSQAIFRLQSGICHLFRETLTNKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQKRFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGIEMGDEEDLSTPNEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNKRLSHVNSLDHLEEDDYNMKEENSNKCWRGYGEKETLLHCRWEC", "length": 529, "header": "tr|A0AAA9S6R3-1|F1MTX7_BOVIN Computationally mapped isoform of Aspartate--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=DARS1 PE=3 SV=1 CANONICAL=F1MTX7-1" }, "locus": { "chromosome": "2", "start_pos": 61461272, "end_pos": 61390858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107586.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107586.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077851.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077851.1" } ] } }, { "isoform_ac": "F1MTX7-1", "url": "https://www.uniprot.org/uniprotkb/F1MTX7/entry", "sequence": { "sequence": "MPSANASRRSQEKPREIMDAAEDYAKERYGVSSMIQSQEKPDRVLVRISDLTVQKAGEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISSAEPRLPLQLDDAVRPEVEGEEDGRATVNQDTRLDNRVIDLRTSTSQAIFRLQSGICHLFRETLTNKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQKRFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGIEMGDEEDLSTPNEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP", "length": 501, "header": "tr|F1MTX7-1|F1MTX7_BOVIN Isoform 1 of Aspartate--tRNA ligase, cytoplasmic OS=Bos taurus OX=9913 GN=DARS1 PE=3 SV=1 CANONICAL=F1MTX7-1" }, "locus": { "chromosome": "2", "start_pos": 61455352, "end_pos": 61390858, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013123.5", "url": "https://www.ensembl.org/id/ENSBTAT00000013123.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013123.2", "url": "https://www.ensembl.org/id/ENSBTAP00000013123.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-9856649", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9856649", "resource": "Reactome", "description": "Transcriptional and post-translational regulation of MITF-M expression and activity" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2N5R4-1", "protein_name": "Aspartate--tRNA ligase, cytoplasmic", "gene_name": "Dars1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPSANASRKGQEKPREIVDAAEDYAKERYGVSSMIQSQEKPDRVLVRVKDLTVQKADDVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIIDVEGIVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEVEGEEEGRATVNQDTRLDNRVIDLRTSTSQAIFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEEDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPRNPKHSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP", "length": 501 }, "evidence": [ { "id": "F1MTX7", "url": "https://omabrowser.org/oma/group/F1MTX7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P04802-1", "protein_name": "Aspartate--tRNA ligase, cytoplasmic", "gene_name": "DPS1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSQDENIVKAVEESAEPAQVILGEDGKPLSKKALKKLQKEQEKQRKKEERALQLEAEREAREKKAAAEDTAKDNYGKLPLIQSRDSDRTGQKRVKFVDLDEAKDSDKEVLFRARVHNTRQQGATLAFLTLRQQASLIQGLVKANKEGTISKNMVKWAGSLNLESIVLVRGIVKKVDEPIKSATVQNLEIHITKIYTISETPEALPILLEDASRSEAEAEAAGLPVVNLDTRLDYRVIDLRTVTNQAIFRIQAGVCELFREYLATKKFTEVHTPKLLGAPSEGGSSVFEVTYFKGKAYLAQSPQFNKQQLIVADFERVYEIGPVFRAENSNTHRHMTEFTGLDMEMAFEEHYHEVLDTLSELFVFIFSELPKRFAHEIELVRKQYPVEEFKLPKDGKMVRLTYKEGIEMLRAAGKEIGDFEDLSTENEKFLGKLVRDKYDTDFYILDKFPLEIRPFYTMPDPANPKYSNSYDFFMRGEEILSGAQRIHDHALLQERMKAHGLSPEDPGLKDYCDGFSYGCPPHAGGGIGLERVVMFYLDLKNIRRASLFPRDPKRLRP", "length": 557 }, "evidence": [ { "id": "F1MTX7", "url": "https://omabrowser.org/oma/group/F1MTX7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P14868-1", "protein_name": "Aspartate--tRNA ligase, cytoplasmic", "gene_name": "DARS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP", "length": 501 }, "evidence": [ { "id": "F1MTX7", "url": "https://omabrowser.org/oma/group/F1MTX7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P15178-1", "protein_name": "Aspartate--tRNA ligase, cytoplasmic", "gene_name": "Dars1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPSANASRKGQEKPREIVDAAEDYAKERYGVSSMIQSQEKPDRVLVRVKDLTVQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIIDVEGIVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAIRPEVEGEEDGRATVNQDTRLDNRIIDLRTSTSQAIFHLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKSNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMDDEEDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP", "length": 501 }, "evidence": [ { "id": "F1MTX7", "url": "https://omabrowser.org/oma/group/F1MTX7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q75JQ1-1", "protein_name": "Aspartate--tRNA ligase, cytoplasmic 1", "gene_name": "aspS1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MSETTPVPVGEAGEKSATALKKEQKKLEKEKKIAEAKAKKAAEKSAASGNSGEQKNEKKQEQVEENNSNWGELPMNQSKEKITREWTDVSQLTESLVGKSVLIRARLSTSRLQGANLCFVQLRDGLYTVQAVVAKGGSNSKSMVQFVGQVPKESIVDVQATVVSTSVPIESCTQKSVELQVSSFFIVSKSTLLPLQIEDLSRAQPLLDKQEDDLKQLEQLLQNTNLNEQEKTDLEKKKSECIKFVNVSQEKRLDNRALDLRVPAHQSIFRLQSGVCTLFREQLLGEGFIEIHSPKIISAASESGASVFKLNYFNTHAYLAQSPQLYKQMAICADFNKVFEIGPVFRAENSNTHRHLTEFVGLDLEMTFKDHYHEALDTLDRLMTSIFRGLETRFAKEIESVNTQYPFEPFKFTYPSPRFTFDEAAAMLAELNDPDYIVKDNDFNTRQEKRLGKIIKEKFGVDFFIVDKFHVEVRPFYTMPDPNNPQWANAYDLFMRGEEICSGAQRIHDPELLEKSAKSHGVVIEDIQGYIDSFKYGCSQHAGGGVGLERVVMLYLGLGNIRKASFCPRDPTRLTP", "length": 576 }, "evidence": [ { "id": "F1MTX7", "url": "https://omabrowser.org/oma/group/F1MTX7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q922B2-1", "protein_name": "Aspartate--tRNA ligase, cytoplasmic", "gene_name": "Dars1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPSTNASRKGQEKPREIVDAAEDYAKERYGISSMIQSQEKPDRVLVRVKDLTVQKADDVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIIDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAIRPEVEGEEDGRATVNQDTRLDNRVIDLRTSTSQAIFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQERFQTEIQTVSKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMDDEEDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP", "length": 501 }, "evidence": [ { "id": "F1MTX7", "url": "https://omabrowser.org/oma/group/F1MTX7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9M084-1", "protein_name": "Aspartate--tRNA ligase 2, cytoplasmic", "gene_name": "IBI1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSSESEIPPLSSSTAAAEESGEKTSKKAAKKEAAKLEKLRRRQEQEEATRRTASISLEENDEFSNNYGDVTLTELQSSADPKAGKWIEAVEGKEWTDVSDLVEEMLESEVLIRGRVHTNRPTSNKLGFVVLRESGSTVQCVVSQSEKTKVGANMVKYLKQLSRESFVDVIGVVTLPKEPLTGTTQQVEIQVRKVYCINKSLAKLPLSVEDAARSEADIEASLQTPSPAARVNQDTRLNYRVLDLRTPANQAIFQLQYEVEYAFREKLRFKNFVGIHTPKLMAGSSEGGSAVFRLEYKGQPACLAQSPQLHKQMAICGDLRRVFEVGPVFRAEDSFTHRHLCEFVGLDVEMEIRKHYSEIMDLVDELFVFIFTSLNERCKKELQAVGKQYPFEPLKFLPKTLRLTFEEGVQMLKEAGVEVDPLGDLNTESERKLGQLVLEKYNTEFYILHRYPKAVRPFYTMTCADNPLYSNSFDVFIRGEEIISGAQRVHIPEVLEQRAGECGIDVKTISTYIDSFRYGAPLHGGFGVGLERVVMLFCALNNIRKTSLFPRDPQRLSP", "length": 558 }, "evidence": [ { "id": "F1MTX7", "url": "https://omabrowser.org/oma/group/F1MTX7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "aspartate-tRNA ligase activity", "id": "GO:0004815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004815", "evidence": [ { "database": "UniProtKB", "id": "F1MTX7", "url": "https://www.uniprot.org/uniprotkb/F1MTX7" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MTX7", "url": "https://www.uniprot.org/uniprotkb/F1MTX7" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "F1MTX7", "url": "https://www.uniprot.org/uniprotkb/F1MTX7" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1MTX7", "url": "https://www.uniprot.org/uniprotkb/F1MTX7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MTX7", "url": "https://www.uniprot.org/uniprotkb/F1MTX7" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1MTX7", "url": "https://www.uniprot.org/uniprotkb/F1MTX7" } ], "pmid": "" }, { "name": "aminoacyl-tRNA synthetase multienzyme complex", "id": "GO:0017101", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017101", "evidence": [ { "database": "UniProtKB", "id": "F1MTX7", "url": "https://www.uniprot.org/uniprotkb/F1MTX7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MTX7", "url": "https://www.uniprot.org/uniprotkb/F1MTX7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "aspartyl-tRNA aminoacylation", "id": "GO:0006422", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006422", "evidence": [ { "database": "UniProtKB", "id": "F1MTX7", "url": "https://www.uniprot.org/uniprotkb/F1MTX7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19649", "name": "", "equation": "tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MTX7-1", "A6QPU5-1", "Q3SYZ4-1", "A0AAA9S1D9-1" ], "evidence": [ { "id": "19649", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19649" } ] }, { "id": "R-BTA-9825759", "name": "MAPK-dependent phosphorylation of KARS", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3S5ZPT9-1", "A0AAA9TDX1-1", "P46196-1", "A7YW98-1", "A0AAA9TMZ2-1", "F1MDW1-1", "F1MTX7-1", "P43481-1", "E1B8P9-1", "Q3MHH4-1" ], "evidence": [ { "id": "R-BTA-9825759", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9825759" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3S5ZPT9", "gene_name": "LARS1", "activity": [ { "ec_number": "6.1.1.4", "activity": "tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate.", "evidence": [ { "id": "A0A3S5ZPT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPT9" } ] }, { "ec_number": "6.1.1.4", "activity": "", "evidence": [ { "id": "A0A3S5ZPT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPT9" } ] } ] }, { "uniprot_ac": "A0AAA9S1D9", "gene_name": "DARS2", "activity": [ { "ec_number": "6.1.1.12", "activity": "tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate.", "evidence": [ { "id": "A0AAA9S1D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1D9" } ] }, { "ec_number": "6.1.1.12", "activity": "", "evidence": [ { "id": "A0AAA9S1D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1D9" } ] } ] }, { "uniprot_ac": "A0AAA9TDX1", "gene_name": "KARS1", "activity": [ { "ec_number": "6.1.1.6", "activity": "tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate.", "evidence": [ { "id": "A0AAA9TDX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX1" } ] }, { "ec_number": "6.1.1.6", "activity": "", "evidence": [ { "id": "A0AAA9TDX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDX1" } ] } ] }, { "uniprot_ac": "A0AAA9TMZ2", "gene_name": "EPRS1", "activity": [ { "ec_number": "6.1.1.15", 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"tr|F1MMI1-1|F1MMI1_BOVIN Isoform 1 of Hemoglobin subunit zeta OS=Bos taurus OX=9913 GN=HBZ PE=3 SV=2 CANONICAL=F1MMI1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8G7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8G7/entry", "sequence": { "sequence": "GGQAVLSSGYRKSHPERSLTRPPARRLFSCYPQAKTYFPHFDLHTGSAQLRAHGSRVVAAVGDAVKSIDNVTSALSKLSELHAYVLRVDPVNFKFLSHCLLVTLASHFPADFTADVHAAWDKFLSIVSGVLTEKYR", "length": 136, "header": "tr|A0AAA9S8G7-1|F1MMI1_BOVIN Computationally mapped isoform of Hemoglobin subunit zeta OS=Bos taurus OX=9913 GN=HBZ PE=3 SV=1 CANONICAL=F1MMI1-1" }, "locus": { "chromosome": "25", "start_pos": 199495, "end_pos": 198888, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134341.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134341.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081554.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081554.1" } ] } }, { "isoform_ac": "F1MMI1-1", "url": "https://www.uniprot.org/uniprotkb/F1MMI1/entry", "sequence": { "sequence": "MSLTRAERTIIVSMWSKISTQADLIGTETLERLFSCYPQAKTYFPHFDLHTGSAQLRAHGSRVVAAVGDAVKSIDNVTSALSKLSELHAYVLRVDPVNFKFLSHCLLVTLASHFPADFTADVHAAWDKFLSIVSGVLTEKYR", "length": 142, "header": "tr|F1MMI1-1|F1MMI1_BOVIN Isoform 1 of Hemoglobin subunit zeta OS=Bos taurus OX=9913 GN=HBZ PE=3 SV=2 CANONICAL=F1MMI1-1" }, "locus": { "chromosome": "25", "start_pos": 199495, "end_pos": 198487, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022037.6", "url": "https://www.ensembl.org/id/ENSBTAT00000022037.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022037.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022037.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100138582", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100138582", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P06467-1", "protein_name": "Hemoglobin subunit zeta", "gene_name": "Hbz", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLMKNERAIIMSMWEKMAAQAEPIGTETLERLFCSYPQTKTYFPHFDLHHGSQQLRAHGFKIMTAVGDAVKSIDNLSSALTKLSELHAYILRVDPVNFKLLSHCLLVTMAARFPADFTPEVHEAWDKFMSILSSILTEKYR", "length": 142 }, "evidence": [ { "id": "F1MMI1", "url": "https://omabrowser.org/oma/group/F1MMI1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MMI1", "url": "https://www.uniprot.org/uniprotkb/F1MMI1" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "F1MMI1", "url": "https://www.uniprot.org/uniprotkb/F1MMI1" } ], "pmid": "" }, { "name": "oxygen binding", "id": "GO:0019825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019825", "evidence": [ { "database": "UniProtKB", "id": "F1MMI1", "url": "https://www.uniprot.org/uniprotkb/F1MMI1" } ], "pmid": "" }, { "name": "oxygen carrier activity", "id": "GO:0005344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005344", "evidence": [ { "database": "UniProtKB", "id": "F1MMI1", "url": "https://www.uniprot.org/uniprotkb/F1MMI1" } ], "pmid": "" }, { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "F1MMI1", "url": "https://www.uniprot.org/uniprotkb/F1MMI1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "hemoglobin complex", "id": "GO:0005833", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005833", "evidence": [ { "database": "UniProtKB", "id": "F1MMI1", "url": "https://www.uniprot.org/uniprotkb/F1MMI1" } ], "pmid": "" }, { "name": "haptoglobin-hemoglobin complex", "id": "GO:0031838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031838", "evidence": [ { "database": "UniProtKB", "id": "F1MMI1", "url": "https://www.uniprot.org/uniprotkb/F1MMI1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "erythrocyte development", "id": "GO:0048821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048821", "evidence": [ { "database": "UniProtKB", "id": "F1MMI1", "url": "https://www.uniprot.org/uniprotkb/F1MMI1" } ], "pmid": "" }, { "name": "oxygen transport", "id": "GO:0015671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015671", "evidence": [ { "database": "UniProtKB", "id": "F1MMI1", "url": "https://www.uniprot.org/uniprotkb/F1MMI1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MMI1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 142, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MMI1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MMI1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MMI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMI1" }, { "id": "PS01033", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01033" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Globin", "eco_id": "ECO_0000259", "start_pos": 2, "end_pos": 142, "start_aa": "Ser", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJP4-1", "uniprot_ac": "F1MJP4", "uniprot_id": "F1MJP4_BOVIN", "mass": { "chemical_mass": 137413.0, "monoisotopic_mass": 137413.0 }, "refseq": { "ac": "XP_005210336", "name": "ADAM DEC1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210336" }, "gene_names": [ { "name": "ADAMDEC1", "type": "recommended", "evidence": [ { "id": "F1MJP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJP4" } ] }, { "name": "ADAMDEC1", "type": "synonym", "evidence": [ { "id": "XP_005210336", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210336" } ] } ], "protein_names": [ { "name": "ADAM DEC1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005210336", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210336" } ] }, { "name": "ADAM like decysin 1", "type": "synonym", "evidence": [ { "id": "F1MJP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJP4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJP4", "url": "https://www.uniprot.org/uniprotkb/F1MJP4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADAMDEC1", "url": "https://www.uniprot.org/uniprotkb/F1MJP4", "locus": {} } ], "crossref": [ { "id": "F1MJP4", "url": "https://alphafold.ebi.ac.uk/entry/F1MJP4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001125", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001125", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000037929", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000037929", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04269", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04269", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "505890", "url": "https://www.ncbi.nlm.nih.gov/gene/505890", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001762", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006586", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006586", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018358", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018358", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034027", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034027", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MJP4", "url": "https://www.orthodb.org/?gene=F1MJP4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MSZ5", "url": "https://www.orthodb.org/?gene=F1MSZ5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11905", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11905", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11905:SF32", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11905:SF32", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00200", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00200", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01421", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01421", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01562", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01562", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005210336", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210336", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SBA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJC3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJP4", "url": "https://www.uniprot.org/uniprotkb/F1MJP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJP4-1", "url": "https://www.uniprot.org/uniprotkb/F1MJP4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSZ5", "url": "https://www.uniprot.org/uniprotkb/F1MSZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSZ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MSZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MWQQLLLMATLLLAPCPVNSIKELPGVQNYEVVYPKRLHPRHKREVKDPGQQENFETELKYEMTVNGKIAVLYLKKNKNLLAPGYTETYYNSSGKAVTTSPQIMDNCYYQGHIVNEKVSDASISTCRGLRGYFSQGDQKYFIEPLSLTNQDEQEHALFKHDPEEQKTKSSCGMNDTIWAPGIHLKALSSTSLATSKDQKFWEKKKYVEYYLVLDHGEFKRHNQDQEEIRKTVFEMVNYINMLYKKLNTYVALIGMEIWNDKDKIDISSNAKLTLENFSKWRTGVLLKRKHHDVAQLLTTVAFSGTTVGLAYISTMCSPDFSAGIIKDHSNNALQVAGTMAHEMGHNFGMFHDNYDCKCPSIECVMDGSLSINIPTDFSSCSRASFEKFFEDKLSNCLFNVPLPTDIISTPICGNQLVEMGEDCDCGTPEECTNICCDAKTCKMKENVQCALGECCEKCQLKKAGEVCRPAKDECDLPEMCDGKSTLCPSDRYQINGFPCQNGKGYCRMGTCPTLEKQCTDLWGPGAQVADKSCFRRNEDGSTYGYCRKVNNTHIPCKAKDATCGKLFCNGGSDYLPWKGRIVTILTCRLFDPEDSSEEIGMVINGTKCGDKKVCINAECVDMERTYKSANCSSKCKGHAVCDHELKCQCKEGWAPPDCSDSSTIFNFSIVVGVLLPVAVIFVMLAIVIRCRSSREKQKLVQRPLSTTDAGLHNQKRKPQMAKTVQPQERSRGKIKLDSEGGEIKLDNWSDHNFVLSRTSQLPAVVSMSLVLLSILCLIIQTQAITIRQTLESELYEVVHPKKLHILHKREIQNNQNEKHGKEERYEPELQYQMMLNGEEVILSLQKAEHLLGPDYTETYYSPGGEEITTRPQNMEHCYYKGHILNEKDSVASISTCDGLRGYFTHHNQRYMIKPLKSTGREEHAILRYNQEELNPANHTCGVRNVGRKQDLIRTSRSLRSPEIEEFLQGEKYIDLLLVLDNAFYKMYNENITVIRSFVFDVINLLNVIYNTIDIQVSLVGMEIWSNSDKIKVVPSTAVTFKNFLNWHYSNLGKMKTHDHAQLLSGVGFKTRMAGLATSNSLCSPSSVAVIEGKRKNSVSLVGVMSHELGHVLGMPDVPHNTKCPSGSCVMNKYLSSKFPKDFSTVSRSHFKKYMLSQKPRCLLQALVPKNMTKPVCGNQLLEVGEDCDCGSPEECTNPCCEAMTCMLKHEVDCGKETEQ", "length": 1219, "header": "tr|F1MJP4-1|F1MJP4_BOVIN Isoform 1 of ADAM like decysin 1 OS=Bos taurus OX=9913 GN=ADAMDEC1 PE=4 SV=4 CANONICAL=F1MJP4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBA4/entry", "sequence": { "sequence": "MWQQLLLMATLLLAPCPVNSIKELPGVQNYEVVYPKRLHPRHKREVKDPGQQENFETELKYEMTVNGKIAVLYLKKNKNLLAPGYTETYYNSSGKAVTTSPQIMDNCYYQGHIVNEKVSDASISTCRGLRGYFSQGDQKYFIEPLSLTNQDEQEHALFKHDPEEQKTKSSCGMNDTIWAPGIHLKALSSTSLALYKKLNTYVALIGMEIWNDKDKIDISSNAKLTLENFSKWRTGVLLKRKHHDVAQLLTTVAFSGTTVGLAYISTMCSPDFSAGIIKDHSNNALQVAGTMAHEMGHNFGMFHDNYDCKCPSIECVMDGSLSINIPTDFSSCSRASFEKFFEDKLSNCLFNVPLPTDIISTPICGNQLVEMGEDCDCGTPEECTNICCDAKTCKMKENVQCALGECCEKCQLKKAGEVCRPAKDECDLPEMCDGKSTLCPSDRYQINGFPCQNGKGYCRMGTCPTLEKQCTDLWGPGAQVADKSCFRRNEDGSTYGYCRKVNNTHIPCKAKDATCGKLFCNGGSDYLPWKGRIVTILTCRLFDPEDSSEEIGMVINGTKCGDKKVCINAECVDMERTYKSANCSSKCKGHAVCDHELKCQCKEGWAPPDCSDSSTIFNFSIVVGVLLPVAVIFVMLAIVIRCRSSREKQKLVQRPLSTTDAGLHNQKRKPQMAKTVQPQELPTNPSFPPPLISTSVSSSFLDSNPKI", "length": 707, "header": "tr|A0AAA9SBA4-1|F1MJP4_BOVIN Computationally mapped isoform of ADAM like decysin 1 OS=Bos taurus OX=9913 GN=ADAMDEC1 PE=4 SV=1 CANONICAL=F1MJP4-1" }, "locus": { "chromosome": "8", "start_pos": 71576732, "end_pos": 71497131, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098188.2", "url": "https://www.ensembl.org/id/ENSBTAT00000098188.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080748.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080748.1" } ] } }, { "isoform_ac": "A0AAA9SJC3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJC3/entry", "sequence": { "sequence": 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"length": 1240, "header": "tr|A0AAA9SJC3-1|F1MJP4_BOVIN Computationally mapped isoform of ADAM like decysin 1 OS=Bos taurus OX=9913 GN=ADAMDEC1 PE=4 SV=1 CANONICAL=F1MJP4-1" }, "locus": { "chromosome": "8", "start_pos": 71614994, "end_pos": 71497131, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105641.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105641.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083908.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083908.1" } ] } }, { "isoform_ac": "F1MJP4-1", "url": "https://www.uniprot.org/uniprotkb/F1MJP4/entry", "sequence": { "sequence": "MWQQLLLMATLLLAPCPVNSIKELPGVQNYEVVYPKRLHPRHKREVKDPGQQENFETELKYEMTVNGKIAVLYLKKNKNLLAPGYTETYYNSSGKAVTTSPQIMDNCYYQGHIVNEKVSDASISTCRGLRGYFSQGDQKYFIEPLSLTNQDEQEHALFKHDPEEQKTKSSCGMNDTIWAPGIHLKALSSTSLATSKDQKFWEKKKYVEYYLVLDHGEFKRHNQDQEEIRKTVFEMVNYINMLYKKLNTYVALIGMEIWNDKDKIDISSNAKLTLENFSKWRTGVLLKRKHHDVAQLLTTVAFSGTTVGLAYISTMCSPDFSAGIIKDHSNNALQVAGTMAHEMGHNFGMFHDNYDCKCPSIECVMDGSLSINIPTDFSSCSRASFEKFFEDKLSNCLFNVPLPTDIISTPICGNQLVEMGEDCDCGTPEECTNICCDAKTCKMKENVQCALGECCEKCQLKKAGEVCRPAKDECDLPEMCDGKSTLCPSDRYQINGFPCQNGKGYCRMGTCPTLEKQCTDLWGPGAQVADKSCFRRNEDGSTYGYCRKVNNTHIPCKAKDATCGKLFCNGGSDYLPWKGRIVTILTCRLFDPEDSSEEIGMVINGTKCGDKKVCINAECVDMERTYKSANCSSKCKGHAVCDHELKCQCKEGWAPPDCSDSSTIFNFSIVVGVLLPVAVIFVMLAIVIRCRSSREKQKLVQRPLSTTDAGLHNQKRKPQMAKTVQPQERSRGKIKLDSEGGEIKLDNWSDHNFVLSRTSQLPAVVSMSLVLLSILCLIIQTQAITIRQTLESELYEVVHPKKLHILHKREIQNNQNEKHGKEERYEPELQYQMMLNGEEVILSLQKAEHLLGPDYTETYYSPGGEEITTRPQNMEHCYYKGHILNEKDSVASISTCDGLRGYFTHHNQRYMIKPLKSTGREEHAILRYNQEELNPANHTCGVRNVGRKQDLIRTSRSLRSPEIEEFLQGEKYIDLLLVLDNAFYKMYNENITVIRSFVFDVINLLNVIYNTIDIQVSLVGMEIWSNSDKIKVVPSTAVTFKNFLNWHYSNLGKMKTHDHAQLLSGVGFKTRMAGLATSNSLCSPSSVAVIEGKRKNSVSLVGVMSHELGHVLGMPDVPHNTKCPSGSCVMNKYLSSKFPKDFSTVSRSHFKKYMLSQKPRCLLQALVPKNMTKPVCGNQLLEVGEDCDCGSPEECTNPCCEAMTCMLKHEVDCGKETEQ", "length": 1219, "header": "tr|F1MJP4-1|F1MJP4_BOVIN Isoform 1 of ADAM like decysin 1 OS=Bos taurus OX=9913 GN=ADAMDEC1 PE=4 SV=4 CANONICAL=F1MJP4-1" }, "locus": { "chromosome": "8", "start_pos": 71614994, "end_pos": 71497131, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001496.8", "url": "https://www.ensembl.org/id/ENSBTAT00000001496.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001496.7", "url": "https://www.ensembl.org/id/ENSBTAP00000001496.7" } ] } }, { "isoform_ac": "F1MSZ5-1", "url": "https://www.uniprot.org/uniprotkb/F1MSZ5/entry", "sequence": { "sequence": "MWQQLLLMATLLLAPCPVNSIKELPGVQNYEVVYPKRLHPRHKREVKDPGQQENFETELKYEMTVNGKIAVLYLKKNKNLLAPGYTETYYNSSGKAVTTSPQIMDNCYYQGHIVNEKVSDASISTCRGLRGYFSQGDQKYFIEPLSLTNQDEQEHALFKHDPEEQKTKSSCGMNDTIWAPGIHLKALSSTSLATSKDQKFWEKKKYVEYYLVLDHGEFKRHNQDQEEIRKTVFEMVNYINMLYKKLNTYVALIGMEIWNDKDKIDISSNAKLTLENFSKWRTGVLLKRKHHDVAQLLTTVAFSGTTVGLAYISTMCSPDFSAGIIKDHSNNALQVAGTMAHEMGHNFGMFHDNYDCKCPSIECVMDGSLSINIPTDFSSCSRASFEKFFEDKLSNCLFNVPLPTDIISTPICGNQLVEMGEDCDCGTPEECTNICCDAKTCKMKENVQCALGECCEKCQLKKAGEVCRPAKDECDLPEMCDGKSTLCPSDRYQINGFPCQNGKGYCRMGTCPTLEKQCTDLWGPGAQVADKSCFRRNEDGSTYGYCRKVNNTHIPCKAKDATCGKLFCNGGSDYLPWKGRIVTILTCRLFDPEDSSEEIGMVINGTKCGDKKVCINAECVDMERTYKSANCSSKCKGHAVCDHELKCQCKEGWAPPDCSDSSTIFNFSIVVGVLLPVAVIFVMLAIVIRCRSSREKQKLVQRPLSTTDAGLHNQKRKPQMAKTVQPQEDSNPKI", "length": 734, "header": "tr|F1MSZ5-1|F1MSZ5_BOVIN Computationally mapped isoform of ADAM like decysin 1 OS=Bos taurus OX=9913 GN=ADAMDEC1 PE=4 SV=3 CANONICAL=F1MJP4-1" }, "locus": { "chromosome": "8", "start_pos": 71576732, "end_pos": 71497131, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055272.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055272.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048880.3", "url": "https://www.ensembl.org/id/ENSBTAP00000048880.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "F1MJP4", "url": "https://www.uniprot.org/uniprotkb/F1MJP4" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MJP4", "url": "https://www.uniprot.org/uniprotkb/F1MJP4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1MJP4", "url": "https://www.uniprot.org/uniprotkb/F1MJP4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MJP4", "url": "https://www.uniprot.org/uniprotkb/F1MJP4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1170, "end_pos": 1172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 550, "end_pos": 552, "annotation": "n_glycosylation_sequon" }, { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" }, { 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMA2-1", "uniprot_ac": "F1MMA2", "uniprot_id": "F1MMA2_BOVIN", "mass": { "chemical_mass": 43270.0, "monoisotopic_mass": 43270.0 }, "refseq": { "ac": "NP_001106704", "name": "tubulin--tyrosine ligase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106704" }, "gene_names": [ { "name": "TTL", "type": "recommended", "evidence": [ { "id": "F1MMA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMA2" } ] }, { "name": "TTL", "type": "synonym", "evidence": [ { "id": "NP_001106704", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106704" } ] } ], "protein_names": [ { "name": "Tubulin--tyrosine ligase", "type": "recommended", "evidence": [ { "id": "F1MMA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMA2/entry#names_and_taxonomy" } ] }, { "name": "6.3.2.25", "type": "synonym", "evidence": [ { "id": "F1MMA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMA2/entry#names_and_taxonomy" } ] }, { "name": "tubulin--tyrosine ligase", "type": "synonym", "evidence": [ { "id": "NP_001106704", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106704" } ] } ], "function": [ { "annotation": "Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL1#function" }, { "database": "UniProtKB", "id": "ARBA00037791", "url": "https://www.uniprot.org/uniprotkb/ARBA00037791#function" }, { "database": "UniProtKB", "id": "A0AAA9SKY9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY9#function" }, { "database": "UniProtKB", "id": "F1MMA2", "url": "https://www.uniprot.org/uniprotkb/F1MMA2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMA2", "url": "https://www.uniprot.org/uniprotkb/F1MMA2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TTL", "url": "https://www.uniprot.org/uniprotkb/F1MMA2", "locus": { "chromosome": "11", "start_pos": 46242645, "end_pos": 46209081, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014159", "url": "https://www.ensembl.org/id/ENSBTAG00000014159" } ] } } ], "crossref": [ { "id": "F1MMA2", "url": "https://alphafold.ebi.ac.uk/entry/F1MMA2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014159", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014159", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "514559", "url": "https://www.ncbi.nlm.nih.gov/gene/514559", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004344", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004344", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052492", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052492", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:514559", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514559", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LDKTCHL", "url": "https://omabrowser.org/oma/group/LDKTCHL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MMA2", "url": "https://www.orthodb.org/?gene=F1MMA2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46570", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46570", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46570:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46570:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03133", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03133", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001106704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106704", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17605", "url": "https://www.rhea-db.org/rhea/17605", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SBL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKY9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMA2", "url": "https://www.uniprot.org/uniprotkb/F1MMA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMA2-1", "url": "https://www.uniprot.org/uniprotkb/F1MMA2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLMQLVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIHPPLHSSRTDEREFFLASYNRKKEEGEGNVWIAKSSAGAKGEGILISSDATELLDFIDNQGQVHVIQKYLERPLLLEPGHRKFDIRSWVLVDHQFNIYLYREGVLRTASEPYHMDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFEAFNRYLTSALNITLESSILLQIKHIIRSCLMSVEPAISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAIASVFPPPDAEQQPPQPATFIKL", "length": 377, "header": "tr|F1MMA2-1|F1MMA2_BOVIN Isoform 1 of Tubulin--tyrosine ligase OS=Bos taurus OX=9913 GN=TTL PE=3 SV=1 CANONICAL=F1MMA2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBL1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBL1/entry", "sequence": { "sequence": "MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLMQLVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIHPPLHSSRTDEREFFLASYNRKKEEGEGNVWIAKSSAGAKGEGILISSDATELLDFIDNQGQVHVIQKYLERPLLLEPGHRKFDIRSWVLVDHQFNIYLYREGVLRTASEPYHMDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFEAFNRYLTSALNITLESSILLQIKHIIRSCLMSVEPAISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQSPAKSILHSWILKPANYIVSLSPRPVSAPVFLASCEELCGCPLGVPNQSCPSQ", "length": 393, "header": "tr|A0AAA9SBL1-1|F1MMA2_BOVIN Computationally mapped isoform of Tubulin--tyrosine ligase OS=Bos taurus OX=9913 GN=TTL PE=3 SV=1 CANONICAL=F1MMA2-1" }, "locus": { "chromosome": "11", "start_pos": 46237890, "end_pos": 46209289, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105429.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105429.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083477.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083477.1" } ] } }, { "isoform_ac": "A0AAA9SKY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKY9/entry", "sequence": { "sequence": "MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLMQLVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIHPPLHSSRTDEREFFLASYNRKKEEGEGNVWIAKSSAGAKGEGILISSDATELLDFIDNQGQVHVIQKYLERPLLLEPGHRKFDIRSWVLVDHQFNIYLYREGVLRTASEPYHMDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFEAFNRYLTSALNITLESSILLQIKHIIRSCLMSVEPAISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQFILYICICPTLQIDSSVPLF", "length": 360, "header": "tr|A0AAA9SKY9-1|F1MMA2_BOVIN Computationally mapped isoform of Tubulin--tyrosine ligase OS=Bos taurus OX=9913 GN=TTL PE=3 SV=1 CANONICAL=F1MMA2-1" }, "locus": { "chromosome": "11", "start_pos": 46235460, "end_pos": 46209289, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091525.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091525.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084546.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084546.1" } ] } }, { "isoform_ac": "F1MMA2-1", "url": "https://www.uniprot.org/uniprotkb/F1MMA2/entry", "sequence": { "sequence": "MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLMQLVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIHPPLHSSRTDEREFFLASYNRKKEEGEGNVWIAKSSAGAKGEGILISSDATELLDFIDNQGQVHVIQKYLERPLLLEPGHRKFDIRSWVLVDHQFNIYLYREGVLRTASEPYHMDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFEAFNRYLTSALNITLESSILLQIKHIIRSCLMSVEPAISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAIASVFPPPDAEQQPPQPATFIKL", "length": 377, "header": "tr|F1MMA2-1|F1MMA2_BOVIN Isoform 1 of Tubulin--tyrosine ligase OS=Bos taurus OX=9913 GN=TTL PE=3 SV=1 CANONICAL=F1MMA2-1" }, "locus": { "chromosome": "11", "start_pos": 46242237, "end_pos": 46209289, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018815.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018815.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018815.3", "url": "https://www.ensembl.org/id/ENSBTAP00000018815.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:514559", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514559", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P38160-1", "protein_name": "Tubulin--tyrosine ligase", "gene_name": "TTL", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLMQLVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIHPPIHSSRTDEREFFLTSYNKKKEDGEGNVWIAKSSAGAKGEGILISSEATELLDFIDNQGQVHVIQKYLERPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHTDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFEEFNQYLTSALNITLESSILLQIKHIIRSCLLSVEPAISTRHLPYQSFQLFGFDFMVDEDLKVWLIEVNGAPACAQKLYAELCQGIVDIAIASVFPPPDAEQQQQQPPPAAFIKL", "length": 379 }, "evidence": [ { "id": "F1MMA2", "url": "https://omabrowser.org/oma/group/F1MMA2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P38585-1", "protein_name": "Tubulin--tyrosine ligase", "gene_name": "Ttl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYTFVVRDENSSVYAEVSRLLLATGYWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLAQLVNYYRGADKLCRKASLVKLVKTSPELSESCSWFPESYVIYPTNLKTPVAPAQNGIQLPVSNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDSQGQVHVIQKYLERPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFEEFNQYLTSALNITLESSILLQIKHIIRSCLMSVEPAISTKHLPYQSFQLLGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFPPPDTEQVPQQPAAFVKL", "length": 377 }, "evidence": [ { "id": "F1MMA2", "url": "https://omabrowser.org/oma/group/F1MMA2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8NG68-1", "protein_name": "Tubulin--tyrosine ligase", "gene_name": "TTL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLVQLVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIQPPISNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVHVIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFKEFNQYLTSALNITLESSILLQIKHIIRNCLLSVEPAISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFPPPDVEQPQTQPAAFIKL", "length": 377 }, "evidence": [ { "id": "F1MMA2", "url": "https://omabrowser.org/oma/group/F1MMA2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9QXJ0-1", "protein_name": "Tubulin--tyrosine ligase", "gene_name": "Ttl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYTFVVRQENSSVYAEVSRLLLATGYWKRLRRDNPRFNLMLGGRNRLPFGRLGHEPGLAQLVNYYRGADKLCRKASLVKLVKTSPELSESCSWFPESYVIHPTNLKTPVAPAQNGIQLPVSNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVHVIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFEEFNQYLTSALNITLENSILLQIKHIIRSCLMSVEPAISTKHLPYQSFQLLGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFPPPDTEQVPQQPAAFMKL", "length": 377 }, "evidence": [ { "id": "F1MMA2", "url": "https://omabrowser.org/oma/group/F1MMA2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "tubulin-tyrosine ligase activity", "id": "GO:0004835", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004835", "evidence": [ { "database": "UniProtKB", "id": "F1MMA2", "url": "https://www.uniprot.org/uniprotkb/F1MMA2" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MMA2", "url": "https://www.uniprot.org/uniprotkb/F1MMA2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "F1MMA2", "url": "https://www.uniprot.org/uniprotkb/F1MMA2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "spindle microtubule", "id": "GO:0005876", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005876", "evidence": [ { "database": "UniProtKB", "id": "F1MMA2", "url": "https://www.uniprot.org/uniprotkb/F1MMA2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17605", "name": "", "equation": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine + ATP = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MMA2-1", "P38584-1" ], "evidence": [ { "id": "17605", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17605" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MMA2", "gene_name": "TTL", "activity": [ { "ec_number": "6.3.2.25", "activity": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine + ATP = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMA2" } ] }, { "ec_number": "6.3.2.25", "activity": "", "evidence": [ { "id": "F1MMA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMA2" } ] } ] }, { "uniprot_ac": "P38584", "gene_name": "TTL", "activity": [ { "ec_number": "6.3.2.25", "activity": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine + ATP = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + ADP + phosphate + H(+).", "evidence": [ { "id": "P38584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P38584" } ] }, { "ec_number": "6.3.2.25", "activity": "", "evidence": [ { "id": "P38584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P38584" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MMA2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 377, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MMA2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MMA2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.3.2.25", "ec_name": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine + ATP = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + ADP + phosphate + H(+).", "evidence": [ { "id": "6.3.2.25", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.25" }, { "id": "6.3.2.25", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.3.2.25" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 }, { "start_pos": 276, "end_pos": 278 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", 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"tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MTL6-1", "uniprot_ac": "F1MTL6", "uniprot_id": "F1MTL6_BOVIN", "mass": { "chemical_mass": 49618.0, "monoisotopic_mass": 49618.0 }, "refseq": { "ac": "NP_001138547", "name": "ubiquitin carboxyl-terminal hydrolase 27", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138547" }, "gene_names": [ { "name": "USP27X", "type": "recommended", "evidence": [ { "id": "F1MTL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTL6" } ] }, { "name": "USP27X", "type": "synonym", "evidence": [ { "id": "NP_001138547", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138547" } ] } ], "protein_names": [ { "name": "Ubiquitin carboxyl-terminal hydrolase", "type": "recommended", "evidence": [ { "id": "F1MTL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTL6/entry#names_and_taxonomy" } ] }, { "name": "3.4.19.12", "type": "synonym", "evidence": [ { "id": "F1MTL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTL6/entry#names_and_taxonomy" } ] }, { "name": "ubiquitin carboxyl-terminal hydrolase 27", "type": "synonym", "evidence": [ { "id": "NP_001138547", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138547" } ] } ], "function": [ { "annotation": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SMN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN3#function" }, { "database": "UniProtKB", "id": "RU366025", "url": "https://www.uniprot.org/uniprotkb/RU366025#function" }, { "database": "UniProtKB", "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "USP27X", "url": "https://www.uniprot.org/uniprotkb/F1MTL6", "locus": { "chromosome": "X", "start_pos": 87578300, "end_pos": 87574521, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039391", "url": "https://www.ensembl.org/id/ENSBTAG00000039391" } ] } } ], "crossref": [ { "id": "ENSBTAG00000039391", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039391", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02660", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02660", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "781718", "url": "https://www.ncbi.nlm.nih.gov/gene/781718", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001607", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001607", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050185", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050185", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781718", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781718", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TEKHIHE", "url": "https://omabrowser.org/oma/group/TEKHIHE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MTL6", "url": "https://www.orthodb.org/?gene=F1MTL6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21646", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21646", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21646:SF30", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21646:SF30", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00443", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00443", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02148", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02148", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001138547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138547", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SMN3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SMN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTL6-1", "url": "https://www.uniprot.org/uniprotkb/F1MTL6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCKDYVYDRDIEQIAKEEQGEALKLQASTSTEVSHQQYSVPGLGEKYPTWETTKPELELLGHNPRRRRIASSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDAGKAASNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKESRMNGQLQLPTNSGNDENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVLEHESEKVKEVNTQAY", "length": 438, "header": "tr|F1MTL6-1|F1MTL6_BOVIN Isoform 1 of Ubiquitin carboxyl-terminal hydrolase OS=Bos taurus OX=9913 GN=USP27X PE=3 SV=2 CANONICAL=F1MTL6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SMN3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMN3/entry", "sequence": { "sequence": "MRTRRGVAVAAAETRFLSLPFPPIPRGPPILPRGAANWRQELRVIYQCFVWCGTPETRKSKAKSCICHVCGTHLNRLHSCLSCVFFGCFTEKHIHEHAETKQHNLAVDLYYGGIYCFMCKDYVYDRDIEQIAKEEQGEALKLQASTSTEVSHQQYSVPGLGEKYPTWETTKPELELLGHNPRRRRIASSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDAGKAASNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKESRMNGQLQLPTNSGNDENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVLEHESEKVKEVNTQAY", "length": 555, "header": "tr|A0AAA9SMN3-1|F1MTL6_BOVIN Computationally mapped isoform of Ubiquitin carboxyl-terminal hydrolase OS=Bos taurus OX=9913 GN=USP27X PE=3 SV=1 CANONICAL=F1MTL6-1" }, "locus": { "chromosome": "X", "start_pos": 87577398, "end_pos": 87575552, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096610.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096610.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085135.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085135.1" } ] } }, { "isoform_ac": "F1MTL6-1", "url": "https://www.uniprot.org/uniprotkb/F1MTL6/entry", "sequence": { "sequence": "MCKDYVYDRDIEQIAKEEQGEALKLQASTSTEVSHQQYSVPGLGEKYPTWETTKPELELLGHNPRRRRIASSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDAGKAASNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKESRMNGQLQLPTNSGNDENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVLEHESEKVKEVNTQAY", "length": 438, "header": "tr|F1MTL6-1|F1MTL6_BOVIN Isoform 1 of Ubiquitin carboxyl-terminal hydrolase OS=Bos taurus OX=9913 GN=USP27X PE=3 SV=2 CANONICAL=F1MTL6-1" }, "locus": { "chromosome": "X", "start_pos": 87577398, "end_pos": 87576085, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056161.4", "url": "https://www.ensembl.org/id/ENSBTAT00000056161.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049108.2", "url": "https://www.ensembl.org/id/ENSBTAP00000049108.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:781718", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781718", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A6NNY8-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 27", "gene_name": "USP27X", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MCKDYVYDKDIEQIAKEEQGEALKLQASTSTEVSHQQCSVPGLGEKFPTWETTKPELELLGHNPRRRRITSSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKESRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVLEHESEKVKEMNTQAY", "length": 438 }, "evidence": [ { "id": "F1MTL6", "url": "https://omabrowser.org/oma/group/F1MTL6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "D3ZGB0-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "Usp27x", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCKDYVYDIDIEQIAKEEQGEALKLQASTSTEFSQQQCSVPSLGEKYPTWETTKPELELLGHNPRRRRIASSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKVASNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSLNGESHIPGVTTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMKKLPVVACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKETRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHRDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVLEHEPEKVKEMTTQAY", "length": 438 }, "evidence": [ { "id": "F1MTL6", "url": "https://omabrowser.org/oma/group/F1MTL6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CEG8-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 27", "gene_name": "Usp27x", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCKDYVYDIDIEQIAKEEQGEALKLQASTSTEVSQQQCSVPGLGEKYPTWETTKPELELLGHNPRRRRIASSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKVASNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSLNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMKKLPVVACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKETRVNGQLQLPTNSANNENKYSLFAVVNHQGTLESGHYTSFIRHHRDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVLEPEPEKVKEMTPQAY", "length": 438 }, "evidence": [ { "id": "F1MTL6", "url": "https://omabrowser.org/oma/group/F1MTL6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LEW0-1", "protein_name": "Ubiquitin C-terminal hydrolase 22", "gene_name": "UBP22", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSARISFLKNPDPCNHLSDYKLRYGTDGYKSFNNLFRCFNDARIKIKLQGIDIPRCSYCSVYQKRLYICLICRSISCSSHILLHTQLNKGHDIAIDVERSELYCCACIDQVYDSEFDEVVVSKQLFGLGMSVKSGADVVAVRSNKKRRLDSQLIIGSNFLVSPRDRREKWTFPLGLRGLNNLGSTCFMNAVLQALVHAPPLRNFWLSGQHNRDLCPRRTMGLLCLPCDLDVIFSAMFSGDRTPYSPAHLLYSWWQHSTNLATYEQQDSHEFFISLLDRIHENEGKSKCLYQDNEECQCITHKAFSGLLRSDVTCTTCGSTSTTYDPFIDISLTLDSMNGFSPADCRKNRYSGGPSVNAIMPTLSGCLDFFTRSEKLGPDQKLNCQSCGEKRESSKQMSIRRLPLLLCLHVKRFEHSLTRKTSRKIDSYLQYPFRLNMSPYLSSSIIGKRFGNRIFAFDGEGEYDSSSSSSPSAEFEIFAVVTHKGMLESGHYVTYLRLKGLWYRCDDAWINEVEEEVVRGCECYMLFYAQETVIQKAHKELSYQVISMADAFPFADC", "length": 557 }, "evidence": [ { "id": "F1MTL6", "url": "https://omabrowser.org/oma/group/F1MTL6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VVR1-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase nonstop", "gene_name": "not", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSETGCRHYQSYVKEHSYDTFRVIDAYFAACVNRDARERKAIHCNCFECGSYGIQLYACLHCIYFGCRGAHITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQKSIGWVPWVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSKSSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFYHKNVLEYE", "length": 496 }, "evidence": [ { "id": "F1MTL6", "url": "https://omabrowser.org/oma/group/F1MTL6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6" } ], "pmid": "" }, { "name": "protein K63-linked deubiquitination", "id": "GO:0070536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070536", "evidence": [ { "database": "UniProtKB", "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6" } ], "pmid": "" }, { "name": "positive regulation of type I interferon-mediated signaling pathway", "id": "GO:0060340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060340", "evidence": [ { "database": "UniProtKB", "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6" } ], "pmid": "" }, { "name": "protein K48-linked deubiquitination", "id": "GO:0071108", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071108", "evidence": [ { "database": "UniProtKB", "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6" } ], "pmid": "" }, { "name": "protein deubiquitination", "id": "GO:0016579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016579", "evidence": [ { "database": "UniProtKB", "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase activity", "id": "GO:0004197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004197", "evidence": [ { "database": "UniProtKB", "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6" } ], "pmid": "" }, { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "F1MTL6", "url": "https://www.uniprot.org/uniprotkb/F1MTL6" } ], "pmid": "" }, { "name": "K63-linked deubiquitinase activity", "id": "GO:0061578", "url": 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"GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1350, "start_aa": "Thr", "end_pos": 1350, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1350", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1352, "start_aa": "Thr", "end_pos": 1352, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1352", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1TZ75-1", "protein_name": "Contactin associated protein 1", "gene_name": "CNTNAP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MMRLRLFCILLAAVSGARGWGYYGCDEELVGPLYARSLGASSYYGLFTAPRFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGSFNSWDWVTRYMLLYGDRVDSWTPFYQQGHNSTFFGNVNESGVVRHDLHFHFTARYIRIVPLAWNPRGKIGLRLGIYGCPYKSDVLYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLELQGAHLVLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDANLTLDGYVHRFVLNGDFERLNLDNEMFIGGLVGAAQKNLAYRHNFRGCIENVIFNRVNIADLAVRRHSRITFEGKVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSSLGDGLGHVELILSEGQVNVSIVQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVDGQLVNLTLVEFRRLGYYAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGETCHQPLYKESCEAYRLSGKTSGNFTIDPDGSGPLKPFVVYCDIRENRAWTVVRHDRLWTTRVTGSSMERPFLGAVQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGYPYSFWIGRNEEQHFYWGGSQPGIQRCACGLDRSCVDPALHCNCDADQPQWRTDRGLLTFVDHLPVTQVVVGDTNRSSSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPHCQWRRPYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWLEYDRPLYVGSAELKRRPFIGCLRAMRLNGVTLNLEGRANASEGTSPNCTGHCAHPRFPCFHGGRCVERYSYYTCDCELTAFDGPYCNHDIGGFFEPGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTHSAPAVLLYVSSFVRDYMAVLIKEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEALRVQGELSESNCGAMPRLVSEVPPELDPWYLPPDFPYYHDDGWVAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEPKATHDYHPGSKPPLPTSGPAAAPAPGPAPAPAPTPASAPAPAPAPAPGPRDQNLPQILEESRSE", "length": 1384 }, "evidence": [ { "id": "F1MJQ2", "url": "https://omabrowser.org/oma/group/F1MJQ2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8N7TDM7-1", "protein_name": "Contactin-associated protein 1", "gene_name": "cntnap1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDIRILAPSLLFFLAFQPCSSRPCLDPLISPLYASSFHASSRYNFFYSAHFAKLYGSSGWSPSTRDRQPWMQIDLGRKYRIMAIATQGTFNSYDWVTKYMVLYGDRFDSWTPYVMKGGNMTLPGNWNYYQVKRNVFHYAFTAKHLRIYPMGWNTENGGKIGLRVEFYGCPYDSYVMNFEGDDMVAYSFPRGRMRTLQDHYALNFKTLEKDGILLHSEGLQGDSITLELKTGRLYLHISLGSSTVHNTNGMTTMMLGNLLDTQHWHYVTIKRFGRELNFTLDSQTETTILNGEFQHLDLDKKIYVGGVIEKDMPHLPGKVNFRGCMENVFINGINIIYMTQNQEPEIRLAPKKKKMHYMCRDLLWKPMTFAGPNNYLQLPGFFRKNRLAVKFKFRSWDYTGLLMFTRFADELGSLELGLSEGQVNVTLMQPGNKRLRFAAGYRLNDGFWHTVDLTAKDNLLTITIDEDESSPLKITNPFMVRTGDRYFFGGCPKTNNTARCVTKLSRFHGCMQQIFIDDEPVDIDVMLQRKWGRYAEILLGTCGITDRCSPNPCEHEGRCIQSWNDFLCVCNNTGYKGEVCHNSVYRESCEAYRLNGKYWSGNYTIDPDLSGPLKPFTVYCNMLQKTWTVIEHNRMKSTKVSGSTIDRPYIGDVQYVNASWDEVTALANTSLYCEQWIEFSCYKSRLLNTPHGRPYTYWIGRHNESHEYWGGAFPESGKCGCAVNQTCTDSKYWCNCDADYRQWHSDKGYLSFRDHLPIRRLVIGDTNRTGSEAQYSVGALYCHGDRSIWNTIAFTKPTYLTFPTFKPGTSADITFHFRTYRTYGVFVEASDDHLRNFLRVELNSTTEVVFIFMVGDGIRNVTLRSPKALNDNEWHYVEAEINVKLARLKVDFLPPAIHKFPGQTYITMDFTQPLLVGAANHTLRPFLGCLRGLRMNGVPVDLEGKVDESAGIRRNCTGACLNASIPCRNGGQCIDGYASYACDCNNTGFDGYYCHLDIGAFFDVGAWLRYDVRKEPISFDAWWANFWIEPHWHNFTLGYNTTTDDIEFSFSTLQAPAVLLYISSFSNDYIAVLLKKDGTLSMRYRLGIISYKFKMTDRNMADGFPHFVNITRHNYTVWTQVDYMDPWIEKLVPGEIPRFDSPKSIFLGRVMEVGGVDYEIQRHNSPGFMGCISGVRYNIFAPLKAYFRPNVTNPPVTTQGYVVESNCGAFPPVLGYVPWEDDPWFTGLFFYYIHDDVTPPWMTLIVTVSLMLLFLILYGLYIYLYRYKGSYHTNEPKQLESPSSARPLTDTLRKDRKNLPEIQEESPNE", "length": 1309 }, "evidence": [ { "id": "F1MJQ2", "url": "https://omabrowser.org/oma/group/F1MJQ2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O54991-1", "protein_name": "Contactin-associated protein 1", "gene_name": "Cntnap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMSLRLFSILLATVVSGAWGWGYYGCNEELVGPLYARSLGASSYYGLFTTARFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGAFNSWDWVTRYMLLYGDRVDSWTPFYQKGHNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNPRGKIGLRLGIYGCPYTSSILYFDGDDAISYRFQRGASQSLWDVFAFSFKTEEKDGLLLHTEGSQGDYVTLELQGAHLLLHMSLGSSPIQPRPGHTTVSLGGVLNDLSWHYVRVDRYGRDANFTLDGYAHHFVLNGDFERLNLENEIFIGGLVGAARKNLAYRHNFRGCIENVIYNRINIAEMAVMRHSRITFEGNVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVDGQLVNLTLVEFRKLGYFAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGVTCHEPLYKESCEAYRLSGKYSGNYTIDPDGSGPLKPFVVYCDIRENRAWTVVRHDRLWTTRVTGSSMDRPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGYPYSFWIGRNEEQHFYWGGSQPGIQRCACGLDQSCVDPALHCNCDADQPQWRTDKGLLTFVDHLPVTQVVVGDTNRSNSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPFCRWRRPYVRVELNTSRDVVFAFDIGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWLVYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEGTFPNCTGHCTHPRFPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFETGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYVPGYDTPGYVPGYHGPGYRLPEYPRPGRPVPGYRGPVYNVTGEEVSFSFSTNSAPAVLLYVSSFVRDYMAVLIKEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEAMRVQGELSESNCGAMPRLVSEVPPELDPWYLPPDFPYYHDDGWIAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEPKATHDSHPGGKAPLPPSGPAQAPAPTPAPTQLPTPAPAPAPAPASGPGPRDQNLPQILEESRSE", "length": 1385 }, "evidence": [ { "id": "F1MJQ2", "url": "https://omabrowser.org/oma/group/F1MJQ2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P78357-1", "protein_name": "Contactin-associated protein 1", "gene_name": "CNTNAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMHLRLFCILLAAVSGAEGWGYYGCDEELVGPLYARSLGASSYYSLLTAPRFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGSFNSWDWVTRYMLLYGDRVDSWTPFYQRGHNSTFFGNVNESAVVRHDLHFHFTARYIRIVPLAWNPRGKIGLRLGLYGCPYKADILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLELEGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQRFILNGDFERLNLDTEMFIGGLVGAARKNLAYRHNFRGCIENVIFNRVNIADLAVRRHSRITFEGKVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQTAFHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGETCHTPLYKESCEAYRLSGKTSGNFTIDPDGSGPLKPFVVYCDIRENRAWTVVRHDRLWTTRVTGSSMERPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGYPYSFWIGRNEEQHFYWGGSQPGIQRCACGLDRSCVDPALYCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNRSTSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWMEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEGTSPNCTGHCAHPRLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFEPGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVRDYMAVLIKDDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSINITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEALRVQGELSESNCGAMPRLVSEVPPELDPWYLPPDFPYYHDEGWVAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEPKAAHEYHPGSKPPLPTSGPAQVPTPTAAPNQAPASAPAPAPTPAPAPGPRDQNLPQILEESRSE", "length": 1384 }, "evidence": [ { "id": "F1MJQ2", "url": "https://omabrowser.org/oma/group/F1MJQ2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P97846-1", "protein_name": "Contactin-associated protein 1", "gene_name": "Cntnap1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMSLRLFSILLAAVVSGAQGWGYYGCNEELVGPLYARSLGASSYYGLFTTARFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGAFNSWDWVTRYMLLYGDRVDSWTPFYQQGHNATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNPRGKIGLRLGIYGCPYTSNILYFDGDDAISYRFQRGASQSLWDVFAFSFKTEEKDGLLLHTEGSQGDYVTLELQGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDLSWHYVRVDRYGREANLTLDGYVHRFVLNGDFERLNLENEIFIGGLVGAARKNLAYRHNFRGCIENVIYNRINIAEMAVQRHSRITFEGNVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELMLSEGQVNVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVDGQLVNLTLVEFRKLGYFAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGVTCHEPLYKESCEAYRLSGKYSGNYTIDPDGSGPLKPFVVYCDIRENRAWTVVRHDRLWTTRVTGSSMDRPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGYPYSFWIGRNEEQHFYWGGSQPGIQRCACGLDQSCIDPALHCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNRSSSEAQFFLRPLRCYGDRNSWNTISFRTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPFCQWRRPYVRVELNTSRDVVFAFDIGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWLEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEGTFPNCTGHCTHPRFPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFETGTWMRYNLQSALRSAAQEFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVRDYMAVLIKEDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEAMRVQGELSESNCGAMPRLVSEVPPELDPWYLPPDFPYYHDDGWIAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEPKATHDSHPGGKAPLPPSGPAQAPAPTPAPTQVPTPAPAPASGPGPRDQNLPQILEESRSE", "length": 1381 }, "evidence": [ { "id": "F1MJQ2", "url": "https://omabrowser.org/oma/group/F1MJQ2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "paranodal junction", "id": "GO:0033010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033010", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "paranode region of axon", "id": "GO:0033270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033270", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 20, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "axonogenesis", "id": "GO:0007409", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007409", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "central nervous system myelination", "id": "GO:0022010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022010", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "neuromuscular process controlling balance", "id": "GO:0050885", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050885", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "myelination", "id": "GO:0042552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042552", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "neuron projection morphogenesis", "id": "GO:0048812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048812", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "mitochondrion organization", "id": "GO:0007005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "myelination in peripheral nervous system", "id": "GO:0022011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022011", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "paranodal junction assembly", "id": "GO:0030913", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030913", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "neuromuscular process controlling posture", "id": "GO:0050884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050884", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "paranodal junction maintenance", "id": "GO:1990227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990227", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "regulation of synapse maturation", "id": "GO:0090128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090128", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "neuromuscular junction development, skeletal muscle fiber", "id": "GO:0098529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098529", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "protein localization to juxtaparanode region of axon", "id": "GO:0071205", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071205", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "protein localization to paranode region of axon", "id": "GO:0002175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002175", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "neuronal action potential propagation", "id": "GO:0019227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019227", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" }, { "name": "postsynaptic density organization", "id": "GO:0097106", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097106", "evidence": [ { "database": "UniProtKB", "id": "F1MJQ2", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1078, "end_pos": 1080, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1147, "end_pos": 1149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 420, "end_pos": 422, "annotation": "n_glycosylation_sequon" }, { "start_pos": 499, "end_pos": 501, "annotation": "n_glycosylation_sequon" }, { "start_pos": 518, "end_pos": 520, "annotation": "n_glycosylation_sequon" }, { "start_pos": 597, "end_pos": 599, "annotation": "n_glycosylation_sequon" }, { "start_pos": 653, "end_pos": 655, "annotation": "n_glycosylation_sequon" }, { "start_pos": 664, "end_pos": 666, "annotation": "n_glycosylation_sequon" }, { "start_pos": 763, "end_pos": 765, "annotation": "n_glycosylation_sequon" }, { "start_pos": 804, "end_pos": 806, "annotation": "n_glycosylation_sequon" }, { "start_pos": 843, "end_pos": 845, "annotation": "n_glycosylation_sequon" }, { "start_pos": 860, "end_pos": 862, "annotation": "n_glycosylation_sequon" }, { "start_pos": 948, "end_pos": 950, "annotation": "n_glycosylation_sequon" }, { "start_pos": 956, "end_pos": 958, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 540, "end_pos": 577, "start_aa": "Ile", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" }, { "id": "PS50022", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50022" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "F5/8 type C", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 168, "start_aa": "Cys", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" }, { "id": "PS51406", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51406" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Fibrinogen C-terminal", "eco_id": "ECO_0000259", "start_pos": 576, "end_pos": 628, "start_aa": "Cys", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJQ2" }, { "id": "PS50025", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50025" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Laminin G", "eco_id": "ECO_0000259", "start_pos": 174, "end_pos": 355, "start_aa": "Val", "end_aa": "Cys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1336, 1350, 1352 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1078, "end_pos": 1080 }, { "start_pos": 1147, "end_pos": 1149 }, { "start_pos": 120, "end_pos": 122 }, { "start_pos": 128, "end_pos": 130 }, { "start_pos": 276, "end_pos": 278 }, { "start_pos": 420, "end_pos": 422 }, { "start_pos": 499, "end_pos": 501 }, { "start_pos": 518, "end_pos": 520 }, { "start_pos": 597, "end_pos": 599 }, { "start_pos": 653, "end_pos": 655 }, { "start_pos": 664, "end_pos": 666 }, { "start_pos": 763, "end_pos": 765 }, { "start_pos": 804, "end_pos": 806 }, { "start_pos": 843, "end_pos": 845 }, { "start_pos": 860, "end_pos": 862 }, { "start_pos": 948, "end_pos": 950 }, { "start_pos": 956, "end_pos": 958 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MNY8-1", "uniprot_ac": "F1MNY8", "uniprot_id": "F1MNY8_BOVIN", "mass": { "chemical_mass": 106058.0, "monoisotopic_mass": 106058.0 }, "refseq": {}, "gene_names": [ { "name": "CD163L1", "type": "recommended", "evidence": [ { "id": "F1MNY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNY8" } ] } ], "protein_names": [ { "name": "CD163 molecule-like 1", "type": "synonym", "evidence": [ { "id": "F1MNY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNY8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MNY8", "url": "https://www.uniprot.org/uniprotkb/F1MNY8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CD163L1", "url": "https://www.uniprot.org/uniprotkb/F1MNY8", "locus": {} } ], "crossref": [ { "id": "F1MNY8", "url": "https://alphafold.ebi.ac.uk/entry/F1MNY8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000050749", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000050749", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000051330", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000051330", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000054245", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000054245", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ICSEQES", "url": "https://omabrowser.org/oma/group/ICSEQES/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MNY8", "url": "https://www.orthodb.org/?gene=F1MNY8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MZR1", "url": "https://www.orthodb.org/?gene=G3MZR1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19331", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19331", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19331:SF468", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19331:SF468", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48071", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48071", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48071:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48071:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00530", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00530", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MGT4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MGT4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNY8", "url": "https://www.uniprot.org/uniprotkb/F1MNY8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNY8-1", "url": "https://www.uniprot.org/uniprotkb/F1MNY8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZR1", "url": "https://www.uniprot.org/uniprotkb/G3MZR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZR1-1", "url": "https://www.uniprot.org/uniprotkb/G3MZR1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALGRHLSLRGLCVLLLGTLVGGQALELRLKDGAHRCEGRVEVKHQGEWGTVYAHGWRLKDASVVCRQLGCGAAIGFPGGAYFGPGLGPIWLFYTSCEGTESTVSDCEHSNIKDYRNDSYSHDDDAGVVCSGFVRLAGGDGPCSGRVEVHSGEAWIPVSDGNFTLATAQIICAELGCGKAVSVLGHELFRESSAQVWAEEFRCEGEEPELSVCPRVPCPGGTCHHSGAAQVVCSAYSEVRLMTNGSSQCEGQVEMKISGRWRALCASHWSLANANVICRQLGCGVAISTPGGPHLVEEDDQILTARFHCSGAESFLWSCPVTALGGPDCSHGNTASVICSGNQIQVLPQCNDSLSQPAGSSASEESAPYCSDSRQLRLVDGGGPCAGRVEILDQGSWGTICDDGWDLDDARVVCRQLGCGEALNATGSAHFGAGSGPIWLDNLNCTGKESHVWRCPSRGWGQHNCRHKQDAGVICSEFLALRMVSEDQQCAGWLEVFYNGTWGSVCRSPMEDITVSMICRQLGCGDSGTLNSSVALREGFRPQWVDGIQCRKTDTSLWQCPSDPWNYTSCSPKEEAYIWCADSRQIRLVDGGGRCSGRVEILDQGSWGTICDDRWDLDDARVVCRQLGCGEALDATISSSFGRGSGPIWLDEVNCRGEESQVWRCPTWGWQQHNCDHQEDAGVICSGRRPKSCPTAAACTDREKLRLRGGDSECSGRVEVWHNGSWGTVCDDSWSLAEAEVVCQQLGCGQALEAVRSAAFGPGNGSIWLDEVQCGGRESSLWDCAAEPWGQSDCKHEEDAGVRCSGVRTTLPTTTAGTRTTSNSLPGIFSLPGVLCLILGSLLFLVLVILVTQLLRWRAERRALSSYEDALAEAVYEELDYLLTQKEGLGSPDQTTEVPDENYDDAEEVPVPGTPSPSQGNEEEVPPEKEDGVRSSQTGSCLNFSREAADPGEEEESFWLLQGKKGDAGYDDVELSALGTSPMTFS", "length": 986, "header": "tr|F1MNY8-1|F1MNY8_BOVIN Isoform 1 of CD163 molecule-like 1 OS=Bos taurus OX=9913 GN=CD163L1 PE=4 SV=2 CANONICAL=F1MNY8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MGT4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MGT4/entry", "sequence": { "sequence": "MALGRHLSLRGLCVLLLGTLVGGQALELRLKDGAHRCEGRVEVKHQGEWGTVYAHGWRLKDASVVCRQLGCGAAIGFPGGAYFGPGLGPIWLFYTSCEGTESTVSDCEHSNIKDYRNDSYSHDDDAGVVCSGFVRLAGGDGPCSGRVEVHSGEAWIPVSDGNFTLATAQIICAELGCGKAVSVLGHELFRESSAQVWAEEFRCEGEEPELSVCPRVPCPGGTCHHSGAAQVVCSAYSEVRLMTNGSSQCEGQVEMKISGRWRALCASHWSLANANVICRQLGCGVAISTPGGPHLVEEDDQILTARFHCSGAESFLWSCPVTALGGPDCSHGNTASVICSGNQIQVLPQCNDSLSQPAGSSASEESAPYCSDSRQLRLVDGGGPCAGRVEILDQGSWGTICDDGWDLDDARVVCRQLGCGEALNATGSAHFGAGSGPIWLDNLNCTGKESHVWRCPSRGWGQHNCRHKQDAGVICSEFLALRMVSEDQQCAGWLEVFYNGTWGSVCRSPMEDITVSMICRQLGCGDSGTLNSSVALREGFRPQWVDGIQCRKTDTSLWQCPSDPWNYTSCSPKEEAYIWCADSRQIRLVDGGGRCSGRVEILDQGSWGTICDDRWDLDDARVVCRQLGCGEALDATISSSFGRGSGPIWLDEVNCRGEESQVWRCPTWGWQQHNCDHQEDAGVICSGRRPCPISLSSDSRQLRLVDGGGPCAGRVEILDQGSWGTICDDGWDLDDARVVCRQLGCGEALNATGSAHFGAGSGPIWLDDLNCTGKESHVWRCPSRGWGRHDCRHKEDAGVICSGQHSTLST", "length": 810, "header": "tr|A0A3Q1MGT4-1|F1MNY8_BOVIN Computationally mapped isoform of CD163 molecule-like 1 OS=Bos taurus OX=9913 GN=CD163L1 PE=4 SV=2 CANONICAL=F1MNY8-1" }, "locus": { "chromosome": "5", "start_pos": 103086215, "end_pos": 103036403, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067917.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067917.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070408.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070408.2" } ] } }, { "isoform_ac": "F1MNY8-1", "url": "https://www.uniprot.org/uniprotkb/F1MNY8/entry", "sequence": { "sequence": "MALGRHLSLRGLCVLLLGTLVGGQALELRLKDGAHRCEGRVEVKHQGEWGTVYAHGWRLKDASVVCRQLGCGAAIGFPGGAYFGPGLGPIWLFYTSCEGTESTVSDCEHSNIKDYRNDSYSHDDDAGVVCSGFVRLAGGDGPCSGRVEVHSGEAWIPVSDGNFTLATAQIICAELGCGKAVSVLGHELFRESSAQVWAEEFRCEGEEPELSVCPRVPCPGGTCHHSGAAQVVCSAYSEVRLMTNGSSQCEGQVEMKISGRWRALCASHWSLANANVICRQLGCGVAISTPGGPHLVEEDDQILTARFHCSGAESFLWSCPVTALGGPDCSHGNTASVICSGNQIQVLPQCNDSLSQPAGSSASEESAPYCSDSRQLRLVDGGGPCAGRVEILDQGSWGTICDDGWDLDDARVVCRQLGCGEALNATGSAHFGAGSGPIWLDNLNCTGKESHVWRCPSRGWGQHNCRHKQDAGVICSEFLALRMVSEDQQCAGWLEVFYNGTWGSVCRSPMEDITVSMICRQLGCGDSGTLNSSVALREGFRPQWVDGIQCRKTDTSLWQCPSDPWNYTSCSPKEEAYIWCADSRQIRLVDGGGRCSGRVEILDQGSWGTICDDRWDLDDARVVCRQLGCGEALDATISSSFGRGSGPIWLDEVNCRGEESQVWRCPTWGWQQHNCDHQEDAGVICSGRRPKSCPTAAACTDREKLRLRGGDSECSGRVEVWHNGSWGTVCDDSWSLAEAEVVCQQLGCGQALEAVRSAAFGPGNGSIWLDEVQCGGRESSLWDCAAEPWGQSDCKHEEDAGVRCSGVRTTLPTTTAGTRTTSNSLPGIFSLPGVLCLILGSLLFLVLVILVTQLLRWRAERRALSSYEDALAEAVYEELDYLLTQKEGLGSPDQTTEVPDENYDDAEEVPVPGTPSPSQGNEEEVPPEKEDGVRSSQTGSCLNFSREAADPGEEEESFWLLQGKKGDAGYDDVELSALGTSPMTFS", "length": 986, "header": "tr|F1MNY8-1|F1MNY8_BOVIN Isoform 1 of CD163 molecule-like 1 OS=Bos taurus OX=9913 GN=CD163L1 PE=4 SV=2 CANONICAL=F1MNY8-1" }, "locus": { "chromosome": "5", "start_pos": 103086215, "end_pos": 103022593, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054941.3", "url": "https://www.ensembl.org/id/ENSBTAT00000054941.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049864.2", "url": "https://www.ensembl.org/id/ENSBTAP00000049864.2" } ] } }, { "isoform_ac": "G3MZR1-1", "url": "https://www.uniprot.org/uniprotkb/G3MZR1/entry", "sequence": { "sequence": "QLRLVDGGGPCAGRVEILDQGSWGTICDDGWDLDDARVVCRQLGCGEALNATGSAHFGAGSGPIWLDNLNCTGKESHVWRCPSRGWGQHNCRHKQDAGVICSGFVRLAGGDGPCSGRVEVHSGEAWTPVSDGNFTLPTAQVICAELGCGKAVSVLGHMPFRESDGQVWAEEFRCDGGEPELWSCPRVPCPGGTCLHSGAAQVVCSVYTEVQLMKNGTSQCEGQVEMKISGRWRALCASHWSLANANVVCRQLGCGVAISTPRGPHLVEGGDQISTARFHCSGAESFLWSCPVTALGGPDCSNGNTASVICSGNHTQVLPQCNDFLSQPAGSAASESAPYCSDSRQLRLVDGGGPCAGRVEILDQGSWGTICDDGWDLDDARVVCRQLGCGEALNATGSAHFGAGSGPIWLDDLNCTGKESHVWRCPSRGWGRHDCRHKEDAGVICSEFLALRMVSEDQQCAGWLEVFYNGTWGSVCRSPMEDITVSVICRQLGCGDSGSLNTSVGLREGSRPRWVDLIQCRKMDTSLWQCPSGPWKYSSCSPKEEAYISCEGRRPKSCPTAAACTDREKLRLRGGDSECSGRVEVWHNGSWGTVCDDSWSLAEAEVVCQQLGCGQALEAVRSAAFGPGNGSIWLDEVQCGGRESSLWDCAAEPWGQSDCKHEEDAGVRCSGVRTTLPTTTAGTRTTSNSLPGIFSLPGVLCLILGSLLFLVLVILVTQLLRWRAERRALSSYEDALAEAVYEELDYLLTQKEGLGSPDQTTEVPDENYDDAEEVPVPGTPSPSQGNEEEVPPEKEDGVRSSQTGSCLNFSREAADPGEEEESFWLLQGKKGDAGYDDVELSALGTSPMTFS", "length": 851, "header": "tr|G3MZR1-1|F1MNY8_BOVIN Computationally mapped isoform of CD163 molecule-like 1 OS=Bos taurus OX=9913 GN=CD163L1 PE=4 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"https://alphafold.ebi.ac.uk/entry/F1MRI2" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 251, "end_pos": 253 }, { "start_pos": 49, "end_pos": 51 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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} ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MSB6-1", "uniprot_ac": "F1MSB6", "uniprot_id": "F1MSB6_BOVIN", "mass": { "chemical_mass": 58248.0, "monoisotopic_mass": 58248.0 }, "refseq": { "ac": "NP_001178290", "name": "ubiquitin carboxyl-terminal hydrolase 30", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178290" }, "gene_names": [ { "name": "USP30", "type": "recommended", "evidence": [ { 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regulate different cellular processes.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SSC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSC6#function" }, { "database": "UniProtKB", "id": "RU366025", "url": "https://www.uniprot.org/uniprotkb/RU366025#function" }, { "database": "UniProtKB", "id": "A0AAA9TT90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT90#function" }, { "database": "UniProtKB", "id": "A0AAA9TV40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV40#function" }, { "database": "UniProtKB", "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "USP30", "url": "https://www.uniprot.org/uniprotkb/F1MSB6", "locus": { "chromosome": "17", "start_pos": 63983195, "end_pos": 64006722, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019845", "url": "https://www.ensembl.org/id/ENSBTAG00000019845" } ] } } ], "crossref": [ { "id": "F1MSB6", "url": "https://alphafold.ebi.ac.uk/entry/F1MSB6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019845", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019845", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02662", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02662", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100140210", "url": "https://www.ncbi.nlm.nih.gov/gene/100140210", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100140210", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140210", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CEREGND", "url": "https://omabrowser.org/oma/group/CEREGND/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MSB6", "url": "https://www.orthodb.org/?gene=F1MSB6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24006", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24006", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24006:SF888", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24006:SF888", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00443", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00443", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9664873", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9664873", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001178290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178290", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SSC6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSC6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT90", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TT90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSB6-1", "url": "https://www.uniprot.org/uniprotkb/F1MSB6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSSRASAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPTFIKWLEEFTTQYTGGHKEPPQHQYLSLTLLHLLKALSCQEVTDEEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQTEITPRQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPASTWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFGEFLMMDIYKYHLLGHKPGHRSPEQCEKAGPALELQDGPAAPKSVRNHPGGPKTQIFMNGACSPSLLPALPTPMPFPLPAVPDYSSSTYLFQLMAVVVHHGDMHSGHFVTYRRSPPSAKNPVSASSQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSKMQPQGREYKSEE", "length": 517, "header": "tr|F1MSB6-1|F1MSB6_BOVIN Isoform 1 of Ubiquitin carboxyl-terminal hydrolase OS=Bos taurus OX=9913 GN=USP30 PE=3 SV=3 CANONICAL=F1MSB6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSC6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSC6/entry", "sequence": { "sequence": "MLSSRASAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPTFIKWLEEFTTQYTGGHKEPPQHQYLSLTLLHLLKALSCQEVTDEEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQTEITPRQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPASTWGHPLTLDHCLHHFISSESVRDVVCDNCTKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFGEFLMMDIYKYHLLGHKPGHRSPEQCEKAGPALELQDGPAAPKSVRNHPGGPKTQIFMNGACSPSLLPALPTPMPFPLPAVPDYSSSTYLFQLMAVVVHHGDMHSGHFVTYRRSPPSAKNPVSASSQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSKMQPQGREYKSEE", "length": 490, "header": "tr|A0AAA9SSC6-1|F1MSB6_BOVIN Computationally mapped isoform of Ubiquitin carboxyl-terminal hydrolase OS=Bos taurus OX=9913 GN=USP30 PE=3 SV=1 CANONICAL=F1MSB6-1" }, "locus": { "chromosome": "17", "start_pos": 64006577, "end_pos": 63984927, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104174.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104174.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088234.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088234.1" } ] } }, { "isoform_ac": "A0AAA9TT90-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT90/entry", "sequence": { "sequence": "MLSSRASAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPTFIKWLEEFTTQYTGGHKEPPQHQYLSLTLLHLLKALSCQEVTDEEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQTEITPRQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFGEFLMMDIYKYHLLGHKPGHRSPEQCEKAGPALELQDGPAAPKSVRNHPGGPKTQIFMNGACSPSLLPALPTPMPFPLPAVPDYSSSTYLFQLMAVVVHHGDMHSGHFVTYRRSPPSAKNPVSASSQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSKMQPQGREYKSEE", "length": 468, "header": "tr|A0AAA9TT90-1|F1MSB6_BOVIN Computationally mapped isoform of Ubiquitin carboxyl-terminal hydrolase OS=Bos taurus OX=9913 GN=USP30 PE=3 SV=1 CANONICAL=F1MSB6-1" }, "locus": { "chromosome": "17", "start_pos": 64006577, "end_pos": 63984927, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119571.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119571.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101846.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101846.1" } ] } }, { "isoform_ac": "A0AAA9TV40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV40/entry", "sequence": { "sequence": "MLSSRASAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPTFIKWLEEFTTQYTGGHKEPPQHQYLSLTLLHLLKALSCQEVTDEEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQTEITPRQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPASTWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFGEFLMMDIYKYHLLGHKPGHRSPEQCEKAGPALELQDGPAAPKSVRNHPGGPKTQIFMNGACSPSLLPALPTPMPFPLPAVPDYSSSTYLFQLMAVVVHHGDMHSGHFVTYRRSPPSAKNPVSASSQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSKMQPQARPFWKTDLIWESHGQFLQSSDCCRVTEWRAEGQLRGRLAHAHLPFCTSFSNLSESLHVVKAHLPNPPLWGILSLLHQ", "length": 587, "header": "tr|A0AAA9TV40-1|F1MSB6_BOVIN Computationally mapped isoform of Ubiquitin carboxyl-terminal hydrolase OS=Bos taurus OX=9913 GN=USP30 PE=3 SV=1 CANONICAL=F1MSB6-1" }, "locus": { "chromosome": "17", "start_pos": 64006577, "end_pos": 63984199, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099909.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099909.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101257.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101257.1" } ] } }, { "isoform_ac": "F1MSB6-1", "url": "https://www.uniprot.org/uniprotkb/F1MSB6/entry", "sequence": { "sequence": "MLSSRASAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPTFIKWLEEFTTQYTGGHKEPPQHQYLSLTLLHLLKALSCQEVTDEEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQTEITPRQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPASTWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFGEFLMMDIYKYHLLGHKPGHRSPEQCEKAGPALELQDGPAAPKSVRNHPGGPKTQIFMNGACSPSLLPALPTPMPFPLPAVPDYSSSTYLFQLMAVVVHHGDMHSGHFVTYRRSPPSAKNPVSASSQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSKMQPQGREYKSEE", "length": 517, "header": "tr|F1MSB6-1|F1MSB6_BOVIN Isoform 1 of Ubiquitin carboxyl-terminal hydrolase OS=Bos taurus OX=9913 GN=USP30 PE=3 SV=3 CANONICAL=F1MSB6-1" }, "locus": { "chromosome": "17", "start_pos": 64006577, "end_pos": 63984927, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029564.5", "url": "https://www.ensembl.org/id/ENSBTAT00000029564.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029563.5", "url": "https://www.ensembl.org/id/ENSBTAP00000029563.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:100140210", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100140210", "resource": "KEGG Pathway" }, { "id": "R-BTA-5689880", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" }, { "id": "R-BTA-9664873", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9664873", "resource": "Reactome", "description": "Pexophagy" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZJW5-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "USP30", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLPGGAVRRALRAGAGGRYRAMRSWGVIGGLAAAVAAGIYVLWGPIAERKKRRRGLVPGLLNLGNTCFMNSLLQGLSSCPSFIRWLEEFTAQYKAEQNQPSEQQCLSLTLLHLLRALSCQEVTEDDVLDASCLLEVLRIYRWQISTFEEQDAHELFHVLTSSLEDERDRQPRVTHLFDVHSLEQPEITQKQISCRTRGSLPPMSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRYDTFDSLSLSIPAAMWGHPMTLDHCLHHFISSESVKDVVCDNCTKIQAEGTLNGQSVENQKTTFVKQLKLGKLPQCLCIHLQRLSWSNQGTPLKRHEHVQFNEFLIMDIYKYHIPVHKSTQSDLNQKSSEETKPGTKDGLAVKPSDAEQTCGTKSLLMNGACSSSFLMSSGTFPLTAFPECSSPVYLYRLMAVVVHHGDMHSGHFVTYRRSPPSSKNPLSVSNQWLWISDDTVRKASLQEVLSSSAYLLFYERVHSRVQHQSLELRPEE", "length": 502 }, "evidence": [ { "id": "F1MSB6", "url": "https://omabrowser.org/oma/group/F1MSB6/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZPG5-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 30", "gene_name": "Usp30", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSSRAQAARTAADKALQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFVKWLEEFTTQYSRDQQGPHTHQCLSLTLLSLLKALSCQEVTEEEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEMAPRQVTCHTRGSPHPTTNPWKSQHPFHGRLSSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTQNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSQGTPLKRHEHVQFNEFLMMDFYKYRLLGHKPSQHGPKATESPGSALGVQDTQAAPKPGLSQPAAPKTQFFMNGACSPSLLPALPSPMAFPLPVAPDYSSSMYLFRLMAVVVHHGDMHSGHFVTYRRSPPSAKNPLSTSNQWLWISDDTVRKASLQEVLSSSAYLLFYERVLSRVQQQGREYRSEE", "length": 517 }, "evidence": [ { "id": "F1MSB6", "url": "https://omabrowser.org/oma/group/F1MSB6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3UN04-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 30", "gene_name": "Usp30", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSSRAQAARTAADKALQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFVKWLEEFTTQYSRDQQGPHTHQCLSLTLLNLLKALSCQEVTEDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEMAPRQVTCHTRGSPHPTTNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEARGTLTGEKVEHQRSTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDFYKYRLLGHKPSQHGPKATENPGSAPEVQDAQAAPKPGLSQPGAPKTQIFLNGACSPSLLPALPSPVAFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSAKNPLSTSNQWLWISDDTVRKASLQEVLSSSAYLLFYERVLSRVQQQGREYRSEE", "length": 517 }, "evidence": [ { "id": "F1MSB6", "url": "https://omabrowser.org/oma/group/F1MSB6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q70CQ3-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 30", "gene_name": "USP30", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE", "length": 517 }, "evidence": [ { "id": "F1MSB6", "url": "https://omabrowser.org/oma/group/F1MSB6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9FPS0-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 27", "gene_name": "UBP27", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MVSRRGSETKAIVCVLTDRIRISNQWVSHLSFAGLLGVAGFVFAQQHGLFRNLNNLKLFSGREKDSGDDSFLVPGLQNLGNNCFLNVILQALASCKDFRSFLQWVLEDARGSLAGEQEEQLPLTFALSALLQELGTVGSRRSVSNPRKVMVTLTDYAKNFNLTSQQDAAEALLHLISSLQEEIVVCYRPSQSSNLSDILFSRNLRMLAPSEGLHGLMELKRWHKHLRGPFDGILGSTLMCRTCSSQISLEFQFFHTLPLSPLLHHGGYNIMSGCTLEHCLKKFLNTEKVENYFCYRCWHGAALKYLSVIGAAETEIEKLRSCGGEDQCDCKTSLHLQRMPWSNSYSHILKQLIIARFPKLLCIQVQRASFNMFEEFKLSGHIAFPLVLNLSLFTPSSIGVNIEERIEMSSEYQKPEASKNHGMYRLVTVVEHFGRTGSGHYTVYRSVRVFSQEEEEEDCDEDLSWFSISDSEVCRVSESDVLGAEASLLFYERL", "length": 494 }, "evidence": [ { "id": "F1MSB6", "url": "https://omabrowser.org/oma/group/F1MSB6/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9W462-1", "protein_name": "Ubiquitin carboxyl-terminal hydrolase 30 homolog", "gene_name": "Usp30", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MESEKILMAAGVTVAAVVGAFVFWGPSGSRLRQRRGQIAGLHNFGLTCFLNTLLQAMAACPQFIAWLQLYNNASPDRKSLITSMLNTLEVVNGTHATLRGDPYSPGAVLRALNALGWVIPQEEHDAHELFHVLLTCLEEEAIRPQPLGCLSDALPTDNDDNSSLAGTATPVGGFRSFSSMAAGLGASQRIGDQPNRPSSAMLTDFLNMEYDESTSLQRLVRSEAHTPDSPASVCERDGNDRLGSVLLDAVSPGTPFGFPLVSNPDSLATPMLGGERSSRPRLPQSQQQQDEGLNRRVSSSCRSLERLHRGPGRVSIWSNMMPSQVAHPFQGAMGAQIVCNGCGSKSAVRYDKFDSITLNLPPQRRTGLSLGHLLSEYITSEDLSDVKCDSCNETTTHTKSVTFAKLPACLCIHVARTVWLPTGQVCKRKDYVHFPESLSMAPYSFVQPHLNSQAGTPWGSTMSLYSSSLPMNNGVGGGEGFGTMFPKNLYRLLAVVVHSGEANSGHFVTYRRGSLRNAHRWYYTSDTIVREVSIDEVLSVPAYLLFYDRGQQRQLNLR", "length": 558 }, "evidence": [ { "id": "F1MSB6", "url": "https://omabrowser.org/oma/group/F1MSB6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ], "pmid": "" }, { "name": "protein deubiquitination", "id": "GO:0016579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016579", "evidence": [ { "database": "UniProtKB", "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ], "pmid": "" }, { "name": "mitochondrial fusion", "id": "GO:0008053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008053", "evidence": [ { "database": "UniProtKB", "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ], "pmid": "" }, { "name": "autophagy of mitochondrion", "id": "GO:0000422", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000422", "evidence": [ { "database": "UniProtKB", "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ], "pmid": "" }, { "name": "protein K6-linked deubiquitination", "id": "GO:0044313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044313", "evidence": [ { "database": "UniProtKB", "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ], "pmid": "" }, { "name": "protein K11-linked deubiquitination", "id": "GO:0035871", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035871", "evidence": [ { "database": "UniProtKB", "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ], "pmid": "" }, { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase activity", "id": "GO:0004197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004197", "evidence": [ { "database": "UniProtKB", "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MSB6", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 286, "end_pos": 288, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-5696872", "name": "USP30 deubiquitinates Ub-MOM proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial outer membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q2HJF8-1", "Q24K02-1", "F1MSB6-1", "E1BGD5-1", "A0A3Q1LK42-1", "Q3ZBL5-1" ], "evidence": [ { "id": "R-BTA-5696872", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696872" } ] }, { "id": "R-BTA-9674127", "name": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BEI6-1", "F1MSB6-1" ], "evidence": [ { "id": "R-BTA-9674127", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9674127" } ] }, { "id": "R-BTA-9674131", "name": "USP30 binds ATM dimer:Ub-p-PEX5", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "peroxisomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "E1BEI6-1", "F1MSB6-1" ], "evidence": [ { "id": "R-BTA-9674131", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9674131" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LK42", "gene_name": "FKBP8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A3Q1LK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LK42" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A3Q1LK42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LK42" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BGD5", "gene_name": "MUL1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E1BGD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGD5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E1BGD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGD5" } ] } ] }, { "uniprot_ac": "F1MSB6", "gene_name": "USP30", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "F1MSB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "F1MSB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" } ] } ] }, { "uniprot_ac": "Q24K02", "gene_name": "IDE", "activity": [ { "ec_number": "3.4.24.56", "activity": "Degradation of insulin, glucagon and other polypeptides. No action on proteins.", "evidence": [ { "id": "Q24K02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K02" } ] }, { "ec_number": "3.4.24.56", "activity": "", "evidence": [ { "id": "Q24K02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q24K02" } ] } ] }, { "uniprot_ac": "Q2HJF8", "gene_name": "RHOT1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q2HJF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF8" } ] } ] }, { "uniprot_ac": "Q3ZBL5", "gene_name": "PTRH2", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "Q3ZBL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "Q3ZBL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3ZBL5" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MSB6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 517, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MSB6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MSB6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MSB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSB6" }, { "id": "PS50235", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50235" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "USP", "eco_id": "ECO_0000259", "start_pos": 68, "end_pos": 502, "start_aa": "Pro", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.19.12", "ec_name": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "3.4.19.12", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.19.12" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 286, "end_pos": 288 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { 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}, { "id": "NP_001192407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192407", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SXP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS28", "url": "https://www.uniprot.org/uniprotkb/F1MS28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS28-1", "url": "https://www.uniprot.org/uniprotkb/F1MS28-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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36896430, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108031.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108031.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090133.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090133.1" } ] } }, { "isoform_ac": "F1MS28-1", "url": "https://www.uniprot.org/uniprotkb/F1MS28/entry", "sequence": { "sequence": 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PI3K/AKT Signaling" }, { "id": "R-BTA-8847993", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8847993", "resource": "Reactome", "description": "ERBB2 Activates PTK6 Signaling" }, { "id": "R-BTA-8863795", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8863795", "resource": "Reactome", "description": "Downregulation of ERBB2 signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5Y1H8-1", "protein_name": "Pro-neuregulin-3, membrane-bound isoform", "gene_name": "Nrg3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEGAAGASPPGAASAAAASAEEGTAAAAAAAAAAAAAGGGPDGGGEGAAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSTGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTARNTAAPPTVLSTTSPFFSSSTPGSRPPMPGAPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAAAASSSSPSSTSSTTTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEDVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEHLKESQNGKNYSLKASSTMTKSESLMKSHVQLQNYSKADRHPVTALEKIMESSFTAPQLFPEVTSDRGSQPIKHHSRSISSCGSPGQRSGMLHRNTFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYASNGLRTQQNASINMQLPSRETNPYFNSLDQKDLVGYLSPRANSVPIIPSVGLEETCMQMPGISDVKSIKWCKNSYSADIVNASIPVSDCLLEEQQEVKILLETVQEQIRILTDARRSEDYELASMETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSVLTK", "length": 727 }, "evidence": [ { "id": "F1MS28", "url": "https://omabrowser.org/oma/group/F1MS28/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O35181-1", "protein_name": "Pro-neuregulin-3, membrane-bound isoform", "gene_name": "Nrg3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSEGAAGASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEGAAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTARNTAAPPTVLSTTAPFFSSSTPGSRPPMPGAPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAAAASSSSPSSTSSTTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEDVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEHLKESQNGKNYSLKASSTKSESLMKSHVHLQNYSKADRHPVTALEKIMESSFSAPQSFPEVTSPDRGSQPIKHHSPGQRSGMLHRNTFRRAPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYVSNGLRTQQNASINMQLPSRETNPYFNSLDQKDLVGYLSPRANSVPIIPSMGLEETCMQMPGISDVKSIKWCKNSYSADIVNASMPVSDCLLEEQQEVKILLETVQEQIRILTDARRSEDFELASMETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSVLTK", "length": 713 }, "evidence": [ { "id": "F1MS28", "url": "https://omabrowser.org/oma/group/F1MS28/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P56975-1", "protein_name": "Pro-neuregulin-3, membrane-bound isoform", "gene_name": "NRG3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEGAAAASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEGAAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTARNTAAPATVPSTTAPFFSSSTLGSRPPVPGTPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAASSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYSSSGLKTQRNTSINMQLPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKILLETVQEQIRILTDARRSEDYELASVETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSALTK", "length": 720 }, "evidence": [ { "id": "F1MS28", "url": "https://omabrowser.org/oma/group/F1MS28/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "F1MS28", "url": "https://www.uniprot.org/uniprotkb/F1MS28" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1MS28", "url": "https://www.uniprot.org/uniprotkb/F1MS28" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MS28", "url": "https://www.uniprot.org/uniprotkb/F1MS28" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "synapse assembly", "id": "GO:0007416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007416", "evidence": [ { "database": "UniProtKB", "id": "F1MS28", "url": "https://www.uniprot.org/uniprotkb/F1MS28" } ], "pmid": "" }, { "name": "modulation of chemical synaptic transmission", "id": "GO:0050804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050804", "evidence": [ { "database": "UniProtKB", "id": "F1MS28", "url": "https://www.uniprot.org/uniprotkb/F1MS28" } ], "pmid": "" }, { "name": "ERBB4-ERBB4 signaling pathway", "id": "GO:0038138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038138", "evidence": [ { "database": "UniProtKB", "id": "F1MS28", "url": "https://www.uniprot.org/uniprotkb/F1MS28" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "F1MS28", "url": "https://www.uniprot.org/uniprotkb/F1MS28" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1MS28", "url": "https://www.uniprot.org/uniprotkb/F1MS28" } ], "pmid": "" }, { "name": "animal organ development", "id": "GO:0048513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048513", "evidence": [ { "database": "UniProtKB", "id": "F1MS28", "url": "https://www.uniprot.org/uniprotkb/F1MS28" } ], "pmid": "" }, { "name": "ERBB4 signaling pathway", "id": "GO:0038130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038130", "evidence": [ { "database": "UniProtKB", "id": "F1MS28", "url": "https://www.uniprot.org/uniprotkb/F1MS28" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "growth factor activity", "id": "GO:0008083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008083", "evidence": [ { "database": "UniProtKB", "id": "F1MS28", "url": "https://www.uniprot.org/uniprotkb/F1MS28" } ], "pmid": "" }, { "name": "chemorepellent activity", "id": "GO:0045499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045499", "evidence": [ { "database": "UniProtKB", "id": "F1MS28", "url": "https://www.uniprot.org/uniprotkb/F1MS28" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 409, "end_pos": 411, "annotation": "n_glycosylation_sequon" }, { "start_pos": 433, "end_pos": 435, "annotation": "n_glycosylation_sequon" }, { "start_pos": 544, "end_pos": 546, "annotation": "n_glycosylation_sequon" }, { "start_pos": 616, "end_pos": 618, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MS28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS28" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 291, "end_pos": 334, "start_aa": "His", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 216 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 409, "end_pos": 411 }, { "start_pos": 433, "end_pos": 435 }, { "start_pos": 544, "end_pos": 546 }, { "start_pos": 616, "end_pos": 618 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MPS0-1", "uniprot_ac": "F1MPS0", "uniprot_id": "F1MPS0_BOVIN", "mass": { "chemical_mass": 167245.0, "monoisotopic_mass": 167245.0 }, "refseq": {}, "gene_names": [ { "name": "NCAPD3", "type": "recommended", "evidence": [ { "id": "F1MPS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPS0" } ] } ], "protein_names": [ { "name": "Condensin-2 complex subunit D3", "type": "recommended", "evidence": [ { "id": "F1MPS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPS0/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SZZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ6#function" }, { "database": "UniProtKB", "id": "ARBA00057333", "url": "https://www.uniprot.org/uniprotkb/ARBA00057333#function" }, { "database": "UniProtKB", "id": "A0AAA9T7V7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7V7#function" }, { "database": "UniProtKB", "id": "F1MPS0", "url": "https://www.uniprot.org/uniprotkb/F1MPS0#function" }, { "database": "UniProtKB", "id": "A0AAA9TA53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA53#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MPS0", "url": "https://www.uniprot.org/uniprotkb/F1MPS0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NCAPD3", "url": "https://www.uniprot.org/uniprotkb/F1MPS0", "locus": { "chromosome": "15", "start_pos": 83443176, "end_pos": 83503594, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002260", "url": "https://www.ensembl.org/id/ENSBTAG00000002260" } ] } } ], "crossref": [ { "id": "ENSBTAG00000002260", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002260", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026971", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026971", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032682", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032682", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MPS0", "url": "https://www.orthodb.org/?gene=F1MPS0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14222", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14222", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14222:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14222:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12717", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12717", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26777", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26777", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26778", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26778", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26779", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26779", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2299718", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2299718", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SZZ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7V7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7V7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7V7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7V7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA53", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA53", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA53-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPS0", "url": "https://www.uniprot.org/uniprotkb/F1MPS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPS0-1", "url": "https://www.uniprot.org/uniprotkb/F1MPS0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEACGNLACALQTWCPLDLSQEWVDGVWELEFTETEPLDASIEAEIVQTGLSAFTELYSAMLPFATEKREAAESIWTFFLENRISHNALMALFHHFVYKVLKKNVSAQQQEFGLHAAGLYFLLLEVPGSVVNQVFHPVIFDKCIQILKKCWPQESSSNQKRKKEQPKNTQGSSQESSKRARPHRREEVEMDEITQEEEDEENIFFSSEDRRQIRNVIFQVLKNFIRLLSKFSLKEKPECIQNCVEVFVALTSSEPVRYEFQATQARILREMKCIPELAYHGLYLLCSPLHREGDKVLRYVLHQMLCIILMVEVGKGSHHTPLAITPPVVSSRKLAVQFVSLLVDELKESMYPVLRTLLQHICVKVVDKSEYRTYAAQSLVQLLNKLPCAEYASFMAWLYGLTRNAKVSHRVFTLDVALALLELPEREVDGPLAPEHEKFLKHKFLVQEILVARCKDKAPTVRSKALSSFALCLESSATAPSDSIQELLHNTPAVPGVQSHRQSPSTNSSAFSYQRQILNPSAGSEVIHTDSSGEGARSMAEMGFLVSLRNRVGDEKTSVRKSAVQVLVNLLKHCDVEGLQDELSILQDRCRDVAVSVRKQALQSLTELLLAQPQRVQIQKAWLGGVVPAVTDDESSVQDKALECLDRLLLQSIQHHSEGHDADSGQALAWALLTLLDTDSRKLGCYLNKAFHIWSRKDRFSPTFVNNVLSHTEKEHSAPAWMLLAKVAGASPMPDYSTVIEAWERMSSQQSPSEDTLGHILCVIRHIAKHLPQSTRDMVADVLKKKLNGFCWSTMLISPAVDTLQSLCRATAETPAEEQELLVQASEDVLATCVRHLSDIILKEDGPGRMREDLMVKYVFTLGDVAQLCPARVDQRTTLLILSILAASPSREPRPQAPPGSSVALASQPLSQVQGVVMPSVVRAHAVITLGKLCLQHDDLAKESVPVLVRELEVGIDGNVLNNIVIVLCDLCVRYTALVDKYIPTICTCLKDPNPFVRKQALLLLTGLLQCASSSSLQEDFVRWKGCLFFRFVITVVDPNPEVASTGEVCLVHLLLKRNPTIFYQHFIECIFHFTGYEKHESFNRFPQSDREKRLFSLKGGKNRERRMRIYKFLLEHFTDEQRFNITSRIFENVLACFADGDLPLDMEASELLSDTFEVLSSKEIRLQVLRARADRDQLGEEEELAPARAALQESQKKLLSQVQKRNLIEMIIPIIASLKSALEKNKIPALRELMLYLREVMQDYGDEVQDFFTVDKQLAAELEYDMRRYQEQLAEQQQPVLSLETIPAPACREKDPVAAAADQPFTPRPHAAHTAAPLSLVPKDRPVSASTMDILSSVKKVVESRRWHSSRTTGPLPSDSRPESPVPVRVLELESSGADPESSGAVDLETKRGISTPEQTIPNVTFGSEISYIVSPGQSLPLQSRSRRRAPGSRRGSRAAGQGDNVLCLSLPDMPPPQTSQWNVKSPSRSEDRSASRRPRRQASKKRAK", "length": 1490, "header": "tr|F1MPS0-1|F1MPS0_BOVIN Isoform 1 of Condensin-2 complex subunit D3 OS=Bos taurus OX=9913 GN=NCAPD3 PE=4 SV=3 CANONICAL=F1MPS0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZZ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZZ6/entry", "sequence": { "sequence": "MEACGNLACALQTWCPLDLSQEWVDGVWELEFTETEPLDASIEAEIVQTGLSAFTELYSAMLPFATEKREAAESIWTFFLENRISHNALMALFHHFVYKVLKKNVSAQQQEFGLHAAGLYFLLLEVPGSVVNQVFHPVIFDKCIQILKKCWPQESSSNQKRKKEQPKNTQGSSQESSKRARPHRREEVEMDEITQEEEDEENIFFSSEDRRQIRNVIFQVLKNFIRLLSKFSLKEKPECIQNCVEVFVALTSSEPVRYEFQATQARILREMKCIPELAYHGLYLLCSPLHREGDKVLRYVLHQMLCIILMVEVGKGSHHTPLAITPPVVSSRKLAVQFVSLLVDELKESMYPVLRTLLQHICVKVVDKSEYRTYAAQSLVQLLNKLPCAEYASFMAWLYGLTRNAKVSHRVFTLDVALALLELPEREVDGPLAPEHEKFLKHKFLVQEILVARCKDKAPTVRSKALSSFALCLESSATAPSDSIQELLHNTPAVPGVQSHRQSPSTNSSAEMGFLVSLRNRVGDEKTSVRKSAVQVLVNLLKHCDVEGLQDELSILQDRCRDVAVSVRKQALQSLTELLLAQPQRVQIQKAWLGGVVPAVTDDESSVQDKALECLDRLLLQSIQHHSEGHDADSGQALAWALLTLLDTDSRKLGCYLNKAFHIWSRKDRFSPTFVNNVLSHTEKEHSAPAWMLLAKVAGASPMPDYSTVIEAWERMSSQQSPSEDTLGHILCVIRHIAKHLPQSTRDMVADVLKKKLNGFCWSTMLISPAVDTLQSLCRATAETPAEEQELLVQASEDVLATCVRHLSDIILKEDGPGRMREDLMVKYVFTLGDVAQLCPARVDQRTTLLILSILAASPSREPRPQAPPGSSVALASQPLSQVQGVVMPSVVRAHAVITLGKLCLQHDDLAKESVPVLVRELEVGIDGNVLNNIVIVLCDLCVRYTALVDKYIPTICTCLKDPNPFVRKQALLLLTGLLQEDFVRWKGCLFFRFVITVVDPNPEVASTGEVCLVHLLLKRNPTIFYQHFIECIFHFTGYEKHESFNRFPQSDREKRLFSLKGGKNRERRMRIYKFLLEHFTDEQRFNITSRIFENVLACFADGDLPLDMEASELLSDTFEVLSSKEIRLQVLRARADRDQLGEEEELAPARAALQESQKKLLSQVQKRNLIEMIIPIIASLKSALEKNKIPALRELMLYLREVMQDYGDEVQDFFTVDKQLAAELEYDMRRYQEQLAEQQQPVLSLETIPAPACREKDPVAAAADQPFTPRPHAAHTAAPLSLVPKDRPVSASTMDILSSVKKVVESRRWHSSRTTGPLPSDSRPESPVPVRVLELESSGADPESSGAVDLETKRGISTPEQTIPNVTFGSEISYIVSPGQSLPLQSRSRRRAPGSRRGSRAAGQGDNVLCLSLPDMPPPQTSQWNVKSPSRSEDRSASRRPRRQASKKRAK", "length": 1452, "header": "tr|A0AAA9SZZ6-1|F1MPS0_BOVIN Computationally mapped isoform of Condensin-2 complex subunit D3 OS=Bos taurus OX=9913 GN=NCAPD3 PE=4 SV=1 CANONICAL=F1MPS0-1" }, "locus": { "chromosome": "15", "start_pos": 83503035, "end_pos": 83443498, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102023.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102023.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088959.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088959.1" } ] } }, { "isoform_ac": "A0AAA9T7V7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7V7/entry", "sequence": { "sequence": "MEACGNLACALQTWCPLDLSQEWVDGVWELEFTETEPLDASIEAEIVQTGLSAFTELYSAMLPFATEKREAAESIWTFFLENRISHNALMALFHHFVYKVLKKNVSAQQQEFGLHAAGLYFLLLEVPGSVVNQVFHPVIFDKCIQILKKCWPQESSSNQKRKKEQPKNTQGSSQESSKRARPHRREEVEMDEITQEEEDEENIFFSSEDRRQIRNVIFQVLKNFIRLLSKFSLKEKPECIQNCVEVFVALTSSEPVRYEFQATQARILREMKCIPELAYHGLYLLCSPLHREGDKVLRYVLHQMLCIILMVEVGKGSHHTPLAITPPVVSSRKLAVQFVSLLVDELKESMYPVLRTLLQHICVKVVDKSEYRTYAAQSLVQLLNKLPCAEYASFMAWLYGLTRNAKVSHRVFTLDVALALLELPEREVDGPLAPEHEKFLKHKFLVQEILVARCKDKAPTVRSKALSSFALCLESSATAPSDSIQELLHNTPAVPGVQSHRQSPSTNSSAFSYQRQILNPSAGSEVIHTDSSGEGARSMAEMGFLVSLRNRVGDEKTSVRKSAVQVLVNLLKHCDVEGLQDELSILQDRCRDVAVSVRKQALQSLTELLLAQPQRVQIQKAWLGGVVPAVTDDESSVQDKALECLDRLLLQSIQHHSEGHDADSGQALAWALLTLLDTDSRKLGCYLNKAFHIWSRKDRFSPTFVNNVLSHTEKEHSAPAWMLLAKVAGASPMPDYSTVIEAWERMSSQQSPSEDTLGHILCVIRHIAKHLPQSTRDMVADVLKKKLNGFCWSTMLISPAVDTLQSLCRATAETPAEEQDTSLSALGKQERNCRRLQINKELLVQASEDVLATCVRHLSDIILKEDGPGRMREDLMVKYVFTLGDVAQLCPARVDQRTTLLILSILAASPSREPRPQAPPGSSVALASQPLSQVQGVVMPSVVRAHAVITLGKLCLQHDDLAKESVPVLVRELEVGIDGNVLNNIVIVLCDLCVRYTALVDKYIPTICTCLKDPNPFVRKQALLLLTGLLQEDFVRWKGCLFFRFVITVVDPNPEVASTGEVCLVHLLLKRNPTIFYQHFIECIFHFTGYEKHESFNRFPQSDREKRLFSLKGGKNRERRMRIYKFLLEHFTDEQRFNITSRIFENVLACFADGDLPLDMEASELLSDTFEVLSSKEIRLQVLRARADRDQLGEEEELAPARAALQESQKKLLSQVQKRNLIEMIIPIIASLKSALEKNKIPALRELMLYLREVMQDYGDEVQDFFTVDKQLAAELEYDMRRYQEQLAEQQQPVLSLETIPAPACREKDPVAAAADQPFTPRPHAAHTAAPLSLVPKDRPVSASTMDILSSVKKVVESRRWHSSRTTGPLPSDSRPESPVPVRVLELESSGADPESSGAVDLETKRGISTPEQTIPNVTFGSEISYIVSPGQSLPLQSRSRRRAPGSRRGSRAAGQGDNVLCLSLPDMPPPQTSQWNVKSPSRSEDRSASRRPRRQASKKRAK", "length": 1503, "header": "tr|A0AAA9T7V7-1|F1MPS0_BOVIN Computationally mapped isoform of Condensin-2 complex subunit D3 OS=Bos taurus OX=9913 GN=NCAPD3 PE=4 SV=1 CANONICAL=F1MPS0-1" }, "locus": { "chromosome": "15", "start_pos": 83503035, "end_pos": 83443498, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000087905.1", "url": "https://www.ensembl.org/id/ENSBTAT00000087905.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094818.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094818.1" } ] } }, { "isoform_ac": "A0AAA9TA53-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA53/entry", "sequence": { "sequence": "MEACGNLACALQTWCPLDLSQEWVDGVWELEFTETEPLDASIEAEIVQTGLSAFTELYSAMLPFATEKREAAESIWTFFLENRISHNALMALFHHFVYKVLKKNVSAQQQEFGLHAAGLYFLLLEVPGSVVNQVFHPVIFDKCIQILKKCWPQESSSNQKRKKEQPKNTQGSSQESSKRARPHRREEVEMDEITQEEEDEENIFFSSEDRRQIRNVIFQVLKNFIRLLSKFSLKEKPECIQNCVEVFVALTSSEPVRYEFQATQARILREMKCIPELAYHGLYLLCSPLHREGDKVLRYVLHQMLCIILMVEVGKGSHHTPLAITPPVVSSRKLAVQFVSLLVDELKESMYPVLRTLLQHICVKVVDKSEYRTYAAQSLVQLLNKLPCAEYASFMAWLYGLTRNAKVSHRVFTLDVALALLELPEREVDGPLAPEHEKFLKHKFLVQEILVARCKDKAPTVRSKALSSFALCLESSATAPSDSIQELLHNTPAVPGVQSHRQSPSTNSSAFSYQRQILNPSAGSEVIHTDSSGEGARSMEMGFLVSLRNRVGDEKTSVRKSAVQVLVNLLKHCDVEGLQDELSILQDRCRDVAVSVRKQALQSLTELLLAQPQRVQIQKAWLGGVVPAVTDDESSVQDKALECLDRLLLQSIQHHSEGHDADSGQALAWALLTLLDTDSRKLGCYLNKAFHIWSRKDRFSPTFVNNVLSHTEKEHSAPAWMLLAKVAGASPMPDYSTVIEAWERMSSQQSPSEDTLGHILCVIRHIAKHLPQSTRDMVADVLKKKLNGFCWSTMLISPAVDTLQSLCRATAETPAEEQELLVQASEDVLATCVRHLSDIILKEDGPGRMREDLMVKYVFTLGDVAQLCPARVDQRTTLLILSILAASPSREPRPQAPPGSSVALASQPLSQVQGVVMPSVVRAHAVITLGKLCLQHDDLAKESVPVLVRELEVGIDGNVLNNIVIVLCDLCVRYTALVDKYIPTICTCLKDPNPFVRKQALLLLTGLLQEDFVRWKGCLFFRFVITVVDPNPEVASTGEVCLVHLLLKRNPTIFYQHFIECIFHFTGYEKHESFNRFPQSDREKRLFSLKGGKNRERRMRIYKFLLEHFTDEQRFNITSRIFENVLACFADGDLPLDMEASELLSDTFEVLSSKEIRLQVLRARADRDQLGEEEELAPARAALQESQKKLLSQVQKRNLIEMIIPIIASLKSALEKNKIPALRELMLYLREVMQDYGDEVQDFFTVDKQLAAELEYDMRRYQEQLAEQQQPVLSLETIPAPACREKDPVAAAADQPFTPRPHAAHTAAPLSLVPKDRPVSASTMDILSSVKKVVESRRWHSSRTTGPLPSDSRPESPVPVRVLELESSGADPESSGAVDLETKRGISTPERAASGCEGFSALDLIE", "length": 1406, "header": "tr|A0AAA9TA53-1|F1MPS0_BOVIN Computationally mapped isoform of Condensin-2 complex subunit D3 OS=Bos taurus OX=9913 GN=NCAPD3 PE=4 SV=1 CANONICAL=F1MPS0-1" }, "locus": { "chromosome": "15", "start_pos": 83503035, "end_pos": 83444704, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112740.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112740.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092838.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092838.1" } ] } }, { "isoform_ac": "F1MPS0-1", "url": "https://www.uniprot.org/uniprotkb/F1MPS0/entry", "sequence": { "sequence": "MEACGNLACALQTWCPLDLSQEWVDGVWELEFTETEPLDASIEAEIVQTGLSAFTELYSAMLPFATEKREAAESIWTFFLENRISHNALMALFHHFVYKVLKKNVSAQQQEFGLHAAGLYFLLLEVPGSVVNQVFHPVIFDKCIQILKKCWPQESSSNQKRKKEQPKNTQGSSQESSKRARPHRREEVEMDEITQEEEDEENIFFSSEDRRQIRNVIFQVLKNFIRLLSKFSLKEKPECIQNCVEVFVALTSSEPVRYEFQATQARILREMKCIPELAYHGLYLLCSPLHREGDKVLRYVLHQMLCIILMVEVGKGSHHTPLAITPPVVSSRKLAVQFVSLLVDELKESMYPVLRTLLQHICVKVVDKSEYRTYAAQSLVQLLNKLPCAEYASFMAWLYGLTRNAKVSHRVFTLDVALALLELPEREVDGPLAPEHEKFLKHKFLVQEILVARCKDKAPTVRSKALSSFALCLESSATAPSDSIQELLHNTPAVPGVQSHRQSPSTNSSAFSYQRQILNPSAGSEVIHTDSSGEGARSMAEMGFLVSLRNRVGDEKTSVRKSAVQVLVNLLKHCDVEGLQDELSILQDRCRDVAVSVRKQALQSLTELLLAQPQRVQIQKAWLGGVVPAVTDDESSVQDKALECLDRLLLQSIQHHSEGHDADSGQALAWALLTLLDTDSRKLGCYLNKAFHIWSRKDRFSPTFVNNVLSHTEKEHSAPAWMLLAKVAGASPMPDYSTVIEAWERMSSQQSPSEDTLGHILCVIRHIAKHLPQSTRDMVADVLKKKLNGFCWSTMLISPAVDTLQSLCRATAETPAEEQELLVQASEDVLATCVRHLSDIILKEDGPGRMREDLMVKYVFTLGDVAQLCPARVDQRTTLLILSILAASPSREPRPQAPPGSSVALASQPLSQVQGVVMPSVVRAHAVITLGKLCLQHDDLAKESVPVLVRELEVGIDGNVLNNIVIVLCDLCVRYTALVDKYIPTICTCLKDPNPFVRKQALLLLTGLLQCASSSSLQEDFVRWKGCLFFRFVITVVDPNPEVASTGEVCLVHLLLKRNPTIFYQHFIECIFHFTGYEKHESFNRFPQSDREKRLFSLKGGKNRERRMRIYKFLLEHFTDEQRFNITSRIFENVLACFADGDLPLDMEASELLSDTFEVLSSKEIRLQVLRARADRDQLGEEEELAPARAALQESQKKLLSQVQKRNLIEMIIPIIASLKSALEKNKIPALRELMLYLREVMQDYGDEVQDFFTVDKQLAAELEYDMRRYQEQLAEQQQPVLSLETIPAPACREKDPVAAAADQPFTPRPHAAHTAAPLSLVPKDRPVSASTMDILSSVKKVVESRRWHSSRTTGPLPSDSRPESPVPVRVLELESSGADPESSGAVDLETKRGISTPEQTIPNVTFGSEISYIVSPGQSLPLQSRSRRRAPGSRRGSRAAGQGDNVLCLSLPDMPPPQTSQWNVKSPSRSEDRSASRRPRRQASKKRAK", "length": 1490, "header": "tr|F1MPS0-1|F1MPS0_BOVIN Isoform 1 of Condensin-2 complex subunit D3 OS=Bos taurus OX=9913 GN=NCAPD3 PE=4 SV=3 CANONICAL=F1MPS0-1" }, "locus": { "chromosome": "15", "start_pos": 83503035, "end_pos": 83443498, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000039478.6", "url": "https://www.ensembl.org/id/ENSBTAT00000039478.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000039272.5", "url": "https://www.ensembl.org/id/ENSBTAP00000039272.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 325, "start_aa": "Thr", "end_pos": 325, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr325", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-2299718", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2299718", "resource": "Reactome", "description": "Condensation of Prophase Chromosomes" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nuclear lumen", "id": "GO:0031981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031981", "evidence": [ { "database": "UniProtKB", "id": "F1MPS0", "url": "https://www.uniprot.org/uniprotkb/F1MPS0" } ], "pmid": "" }, { "name": "condensin complex", "id": "GO:0000796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000796", "evidence": [ { "database": "UniProtKB", "id": "F1MPS0", "url": "https://www.uniprot.org/uniprotkb/F1MPS0" } ], "pmid": "" }, { "name": "condensed chromosome, centromeric region", "id": "GO:0000779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000779", "evidence": [ { "database": "UniProtKB", "id": "F1MPS0", "url": "https://www.uniprot.org/uniprotkb/F1MPS0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MPS0", "url": "https://www.uniprot.org/uniprotkb/F1MPS0" } ], "pmid": "" }, { "name": "pericentric heterochromatin", "id": "GO:0005721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005721", "evidence": [ { "database": "UniProtKB", "id": "F1MPS0", "url": "https://www.uniprot.org/uniprotkb/F1MPS0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "F1MPS0", "url": "https://www.uniprot.org/uniprotkb/F1MPS0" } ], "pmid": "" }, { "name": "mitotic chromosome condensation", "id": "GO:0007076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007076", "evidence": [ { "database": "UniProtKB", "id": "F1MPS0", "url": "https://www.uniprot.org/uniprotkb/F1MPS0" } ], "pmid": "" }, { "name": "meiotic chromosome condensation", "id": "GO:0010032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010032", "evidence": [ { "database": "UniProtKB", "id": "F1MPS0", "url": "https://www.uniprot.org/uniprotkb/F1MPS0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "histone H4K20me1 reader activity", "id": "GO:0140117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140117", "evidence": [ { "database": "UniProtKB", "id": "F1MPS0", "url": "https://www.uniprot.org/uniprotkb/F1MPS0" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "F1MPS0", "url": "https://www.uniprot.org/uniprotkb/F1MPS0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 104, "end_pos": 106, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1125, "end_pos": 1127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1404, "end_pos": 1406, "annotation": "n_glycosylation_sequon" }, { "start_pos": 507, "end_pos": 509, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MPS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPS0" }, { "id": "PF12717", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12717" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Condensin complex subunit 1 C-terminal", "eco_id": "ECO_0000259", "start_pos": 962, "end_pos": 1134, "start_aa": "Asn", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 325 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 104, "end_pos": 106 }, { "start_pos": 1125, "end_pos": 1127 }, { "start_pos": 1404, "end_pos": 1406 }, { "start_pos": 507, "end_pos": 509 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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"MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREITYFSLWYYNKQNQRRWVDLEKPLKKQLDKHALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGNIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALLPVEWLQDEKVLEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGVFVKHKSGRPPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYVWRLCVARHKFYRLNQCSLQTQTVIVNPVRRRSSSRMSLPKPQPYAMAAPPQLHYNGHYTEPYTSSLDNLFVTNQNGFYGHSQTSLDRAQVELGGRVRNGSVYSAHSTSSLNSPQPYLQPSPGSSNPSITGSDVLRPDYVPSHRHSALIPPSYRPTPDYETVMKQLQRGLAPAERQSRSLRNLSLVYSQPEIREHARPGSPPMAPCAFSLSHSFHSPAPYPYASAAGRRPGLGAVSVPELTNAQLQARDCPAPSILRTQVYRPPPPYPHPRPANSTPDLSRQPPISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTAARRARLQKRNSVELAGLAHGLEGLRLQERAAPALAAGERALRAEDCAAGLRGSLRGGHGKSLSDATVLIHSSDEDEDEDPEEGPAPPLGSRGGRPPDASHAAPLAPGPLHILEPQAPGAAPGEGPRPRRDGLLSPSASESDLTTSGRYRARRDSLQKRPASDLLSAKKNAVEGLPPLGGMKKSRGDAKKIGPLKLAALNGLSLSRLPLPDEEKDVPARATNDERCKILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDARVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCPDFWQMVWEQGIAIIAMVTAEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLSGQERTIWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSASEPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEALDVPRVLDMLRRQRMLMVQTLCQYTFVYRVLIQFLRSSRLI", "length": 1130, "header": "tr|A0AAA9T4A3-1|F1MRH9_BOVIN Computationally mapped isoform of Tyrosine-protein phosphatase non-receptor type OS=Bos taurus OX=9913 GN=PTPN21 PE=3 SV=1 CANONICAL=F1MRH9-1" }, "locus": { "chromosome": "10", "start_pos": 100242684, "end_pos": 100170721, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129050.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129050.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091339.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091339.1" } ] } }, { "isoform_ac": "F1MRH9-1", "url": "https://www.uniprot.org/uniprotkb/F1MRH9/entry", "sequence": { "sequence": "MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREITYFSLWYYNKQNQRRWVDLEKPLKKQLDKHALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGNIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALLPVEWLQDEKVLEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGVFVKHKSGRPPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYVWRLCVARHKFYRLNQCSLQTQTVIVNPVRRRSSSRMSLPKPQPYAMAAPPQLHYNGHYTEPYTSSLDNLFVTNQNGFYGHSQTSLDRAQVELGGRVRNGSVYSAHSTSSLNSPQPYLQPSPGSSNPSITGSDVLRPDYVPSHRHSALIPPSYRPTPDYETVMKQLQRGLAPAERQSRSLRNLSLVYSQPEIREHARPGSPPMAPCAFSLSHSFHSPAPYPYASAAGRRPGLGAVSVPELTNAQLQARDCPAPSILRTQVYRPPPPYPHPRPANSTPDLSRQPPISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTAARRARLQKRNSVELAGLAHGLEGLRLQERAAPALAAGERALRAEDCAAGLRGSLRGGHGKSLSDATVLIHSSDEDEDEDPEEGPAPPLGSRGGRPPDASHAAPLAPGPLHILEPQAPGAAPGEGPRPRRDGLLSPSASESDLTTSGRYRARRDSLQKRPASDLLSAKKNAVEGLPPLGGMKKSRGDAKKIGPLKLAALNGLSLSRLPLPDEEKDVPARATNDERCKILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDARVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCPDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLSGQERTIWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSASEPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEALDVPRVLDMLRRQRMLMVQTLCQYTFVYRVLIQFLRSSRLI", "length": 1131, "header": "tr|F1MRH9-1|F1MRH9_BOVIN Isoform 1 of Tyrosine-protein phosphatase non-receptor type OS=Bos taurus OX=9913 GN=PTPN21 PE=3 SV=3 CANONICAL=F1MRH9-1" }, "locus": { "chromosome": "10", "start_pos": 100242684, "end_pos": 100170721, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024750.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024750.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024750.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024750.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:520178", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:520178", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5P6Q1-1", "protein_name": "protein-tyrosine-phosphatase", "gene_name": "PTPN21", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREITYFSLWYYNKQNQRRWVDLDKPLKKQLDKYALEPTVYFGVVFYVPTVSQLQQEITRYQYYLQLKKDILEGNIPCTLEQAIHLAGLAVQADFGDYDQYESQEFLQRFALFPVGWLQEEKILEEATQKVALLHQKYRGLTPPDAEMLYMQEVERMEGYGEETYPAKDSQGSDIFIGACLDGIFVKHKNSRPPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYVWRMCVARHKFYRLNKCSLDSLDSPPEEGSQKSSLLLSLPRFPILSRPSLPKGQTQPITVNPVRRRSSSRMSMPKPQAYMMPPPPQLHYNGHYTEPYASSQDNLFVSSQNGYYYHSQTSLDRAPHDYSGRIRNGSVYSAHSTNSLNNPQHYLQPSPMSSNPSITGSDVLRTDYVPSHRHSALIPPSYRPTPDYETVMRQLNRGMVHTDRQSHSMRNLNISNTYAYSRPDALVYSQPEIREHAHFTSPQSNHYPFNLNYSFHSPSPYPYPAEKRPVVGAVSVPELTNVQLQAQDYPAPNIMKTQVYRPPPPYPYPRPANSTPDLSRHIYISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTSARHAQLQKRNSIEIAGLTPSFEGIRIKERTMSASAADVALPRVISEGSQPNVLIERTKQKENEQDEGVNCDHKKTLSDATMLIHSSEEEEEEFEENKASTSLSPLPEDQAQLSSIMGGYSHDSVHNYPYSSVASSTGPLHILEPKLHITETEKRMKDISPVHLLVENQVQRRGEGLLTPSMSESDLTTSGRYRVRKDSVKKRPVSDLLSGKKNIVEGLPPLGGMKKNKTDAKKIGPLKLAALNGLTLARMPLPDEGKEESTRATNDERCKVLEQRLEQGMVFTEYERIQKKRLIDGECSIARLPENAERNRFQDVLPYDDTRVELVPTKENNTGYINASHIKISVGGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEESGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKIKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTADPKNSNPPVLVHCSAGVGRTGVVILSEIMIACLEHNEMLDIPRVLDMLRHQRMMMVQTLSQYTFVYGVLIQFLKSSRLI", "length": 1219 }, "evidence": [ { "id": "F1MRH9", "url": "https://omabrowser.org/oma/group/F1MRH9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A286YBL8-1", "protein_name": "protein-tyrosine-phosphatase", "gene_name": "ptpn21", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPLPFGLKLKRTRRYTVSSKSCLVTRIQLLNGEYVEFTLSVESTGQECLEAVAQRLELREITYFSLWYYNKQNQQRWIDLEKPLKKQLDKYGLEPTVYFGVVFYVCTVTQLQQEITRYQYYLQLKKDVLEGKIPCSIEQAIHLASLAVQADLGDFNRYDSQEFLQKIVLFPMPWIQDERVVEEATQKVTMLYQNYRGLSAPEAELLYMQEVEKIEGYGEESIQAKDSQATDVIIGSCLDGIFVKHKNGKAPLIFRWNDINNMTHNKSFFALELANKEDTIQFQTEDMETSKYVCRMWLARHKFYKINNSSLEPSCDPNSEGPQRSILSLSFPRFPALSRLSVPADKGQTQPAPVNPVRRRSSTRMSLPKPQPYMMPPQMHFNGHYNEPYTSSQDNLYINNQNGFYYHSQTSLDRSPHEYNGRIRNGSVYSAQSTSSLNNPQHYLQPSPMSSNPSITGSDLMRPDYVPSHRHSALIPPSYRATPDYETVMRQKNMIPAAERQSHSMRNLNIGNSYAYSRPDPLVYSQPEIREHGAGQYPFHLNYSFHSPSPYPYPTERRPVVGAVSVPELTNVQLQQAQEYPPPNIIRNQVYWPPPPYPYPHPRPANSTPDLSRHLYVSSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLVTARRPHMHKRNSIEIAGLAYGLENMRLKERKVSASAADTPPPVAAAVPHAASGSDINVVLEVSKPEDVGIKEDVFYGHKKSLSDATMLVHSSGEEEEFEDDSGRHTPQSQDAVSGPEHPMTSLGRSLGDPPAYPFSHSMETVLTSPPAYQAHSIMQKAEDVGPLPPLREPGLMMPSVSEGDLSGRLRKNRDISKRPVSDVPPGRRNIDGLPPAGMKKGRSEVKKVGPLKLAALNGLTLSRIPLPDDGKDDPESASNDERCKFLEQRLDQGMVFTEYEQVPKKRPNSEYSIAQMPENNDRNRFQDVLPYDDTRVELVPTKENNTGYINASHIRVTVRGKEWSYIASQGPLSSTCQDFWQMVWEQGVSIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKIKHLLTGQERTVWHLQYTDWPDHGCPEDFKGFLSYLEEIQSVRRHTNSSSDPKNTNLPVLVHCSAGVGRTGVVILSEIMIACLEHNEMLDVPTVLNLLRQQRMMMVQTLSQYTFIYKVLIQFLKNSRLI", "length": 1204 }, "evidence": [ { "id": "F1MRH9", "url": "https://omabrowser.org/oma/group/F1MRH9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3HBF6-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type", "gene_name": "Ptpn21", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLKKQLDKHALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGNLPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALLPVGWLQDENVLEEATQKVALLHQKYRGLTAPEAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACRDGIFVKHKNGRPPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYVWRLCVARHRFYRLNQCDLQTQTATLNPVRRGSSSRMSLPKPQPYAMPPPPQLHYNGHYSEPFASSQDNIFVPNKNGFYCHSQTSLDRTQMDLSGRIRNGSVYSAHSTNSLNTPQPYLQPSPMSSNPSISGSDVMRPDYIPSHRHSALIPPSYRPTPDYETVMKQLNRGMVHADRHSHSLRNLNIGSSYAYSRPDALVYSQPEIREHAHLTSPQSAHYPFNLNYSFHSQSPYPYPAERRPVVGAVSVPELTNVQLQAQDYPAPNIMRTQVYRPPPPYPYPRPANSTPDLSRHLYISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTAARHAHLQKRNSIEIAGLTHGFEGLRLKERTMSASAADVAPRTFSAGSQSSVFSDRTKQEESEEQDSDRYSHKKSLSDATMLIHSSEEEEDLDEDHSRAHTVSAVSEPRLTATYSQEQQLSYPCASVTTVPGPLHILEPKSHFTEPEKRVKDISPVHLLVETHRPRRDGLLTPSMSESDLTTSGRYRVRRDSLKKRPVSDLLSGKKNIVEGLPPLGGMKKTRGDAKKIGPLKLAALNGLSLSRLPLPDEGKEVSTRATNDERCKILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDARVELVPTKENNTGYINASHIKVSVSGTEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSEPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLGQYTFVYRVLIQFLKSSRLI", "length": 1178 }, "evidence": [ { "id": "F1MRH9", "url": "https://omabrowser.org/oma/group/F1MRH9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q16825-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 21", "gene_name": "PTPN21", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVARHKFYRLNQCNLQTQTVTVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQDNLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPSITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSSYAYSRPAALVYSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAERRPVVGAVSVPELTNAQLQAQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLSRHLYISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTAARHAQLHKRNSIEVAGLSHGLEGLRLKERTLSASAAEVAPRAVSVGSQPSVFTERTQREGPEEAEGLRYGHKKSLSDATMLIHSSEEEEDEDFEEESGARAPPARAREPRPGLAQDPPGCPRVLLAGPLHILEPKAHVPDAEKRMMDSSPVRTTAEAQRPWRDGLLMPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMKKTRVDAKKIGPLKLAALNGLSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI", "length": 1174 }, "evidence": [ { "id": "F1MRH9", "url": "https://omabrowser.org/oma/group/F1MRH9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q62136-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 21", "gene_name": "Ptpn21", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLKKQLDKHALEPTVYFGVLFYVPSVSQLQQEITRYQYYLQLKKDILEGNLPCTLEHAIQLAGLAVQADFGDFDQYESQDFLQKFALLPVAWLQDEKVLEEAAQKVALLHQKYRGLTAPEAELLYMQEVERMDGYGEESYPAKDSQGSDISIGACLDGIFVKHKNGRPPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYVWRLCVARHKFYRLNQCSLQTQAATLNSVRRDSSSRMSLPKPQPYAMPPPPQLHYNGHYTEPFASSQDNIFVPNKNGFYCHSQTSLDRTQIDLSGRIRNGSVYSAHSTNSLNTLQPYLQPSPMSSNPSITGSDVMRPDSLPSHRHSALIPPSYRPTPDYETVMKQLNRGMVHADRHSHSLRNLNIGSSYAYSRPDALVYSQPEIREHPHLTSPQSAHYPFNLNYSFHSQSPYPYPAERRPVVGAVSVPELTNVQLQAQDYPAPNIMRTQVYRPPPPYPYPRPANSTPDLSRHLYISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTAARHAHLQKRNSIEIAGLTHGFEGLRLKERTVSASAADVAPRTFSAGSQSSVFSDKMKQEGTEEQEGGRYSHKKSLSDATMLIDSSEEDEDLEEDSSREQAISAVSEPRLTAAFSQELNYPCASATPITGPLHIFEPKPHVTEPEKRAKDISPVHLVVETHRPRRDGLLTPSMSESDLTTSGRYRARRDSVKKRPVSDLLSGKKSAVEGLPPLGGMKKTRADAKKIGPLKLAALNGLSLSRLPLPDEGKEVSTRATNDERCKVLEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDARVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGVAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSEPKSHNPPLLVHCSAGVGRTGVVILSEIMVACLEHNEVLDIPRVLDMLRQQRMMLVQTLGQYTFVYRVLIQFLKSSRLI", "length": 1176 }, "evidence": [ { "id": "F1MRH9", "url": "https://omabrowser.org/oma/group/F1MRH9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q62728-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 21", "gene_name": "Ptpn21", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREITYFSLWYYNKQNQRRWVDLEKPLKKQLDKHALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDVLEGNLPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALLPVGWLQDEKLLEEAAQKVALLHQKYRGLTAPEAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLDGIFVKHKNGRPPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYVWRLCVARHKFYRLNQCNLQTQAATLNSVRRGSSSRMSLPKPQPYAMPPPPQLHYNGHYTEPFASSQDNVFVPNKNGFYCHSQTSLDRTQIDLSGRIRNGSVYSAHSTNSLNTPQPYLQPSPMSSNPSIPGSDVMRPDYIPSHRHSALIPPSYRPTPDYESVMKRLNRGMVHADRHSHSLRNLNIGSSYAYSRPDALVYSQPEIREHPHLASPQSAHYPFNLNYSFHSQAPYPYPVERRPVVGAVSVPELTNVQLQAQDYPAPNIMRTQVYRPPPPYPYPRPANSTPDLSRHLYISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTAARHAHLQKRNSIEIAGLTHGFEGLRLKEETMSASAADVAPRTFSAGSQSSVFSDKVKQEGTEEQGSGGYSHKKSLSDATMLIHSSEEDEDLEDDSSREHAVSEPRLTAAFSQEQQLNYPCASVTPVTGPLHIFEPKSHVTEPEKRAKDISPVHLVMETHQPRRHGLLTPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNTVEGLPPLGGMKKTRADAKKIGPLKLAALNGLSLSRLPLPDEGKEVSTRATNDERCKVLEQRLEQGTVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDARVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGVAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSEPRSPNPPLLVHCSAGVGRTGVVILSEIMVACLEHNEVLDIPRVLELLRQQRMMLVQTLSQYTFVYRVLIQFLKSSRLI", "length": 1175 }, "evidence": [ { "id": "F1MRH9", "url": "https://omabrowser.org/oma/group/F1MRH9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MRH9", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "F1MRH9", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein tyrosine phosphatase activity", "id": "GO:0004725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "evidence": [ { "database": "UniProtKB", "id": "F1MRH9", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of hippo signaling", "id": "GO:0035332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035332", "evidence": [ { "database": "UniProtKB", "id": "F1MRH9", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 261, "end_pos": 263, "annotation": "n_glycosylation_sequon" }, { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" }, { "start_pos": 391, "end_pos": 393, "annotation": "n_glycosylation_sequon" }, { "start_pos": 474, "end_pos": 476, "annotation": "n_glycosylation_sequon" }, { "start_pos": 566, "end_pos": 568, "annotation": "n_glycosylation_sequon" }, { "start_pos": 903, "end_pos": 905, "annotation": "n_glycosylation_sequon" }, { "start_pos": 909, "end_pos": 911, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10684", "name": "", "equation": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1ME76-1", "F1MRH9-1", "A0AAF6DLF7-1", "A0AAA9S9Q3-1", "E1BFE2-1", "E1BL76-1", "G3MXS7-1", "A0A3Q1LUB1-1", "A0AAA9THG9-1", "F1N339-1", "F6RY99-1", "A0AAF6YUC8-1", "A0AAA9RTM1-1", "A0AAA9SMJ6-1", "A0A3Q1LZA9-1", "A7MBD1-1", "A5D7P0-1", "Q58DB6-1", "A0AAA9SEK4-1", "E1BDH9-1", "F1MGK4-1", "E1BIH4-1", "A0A3Q1M6K1-1", "E1BIU8-1", "A7MBJ4-1", "A6H730-1", "A0A3Q1MFX2-1", "A0AAA9U0H6-1", "A2VDT1-1", "E1BPU9-1", "P0C591-1", "P11064-1", "Q0IID7-1", "Q2KJ36-1", "Q2T9S4-1", "E1BPA0-1", "A0AAA9TAZ9-1", "Q5BIP9-1", "A0A3Q1M5K4-1", "F1MM08-1", "E1BJR7-1", "Q17QJ3-1", "Q17QM8-1", "F1MD22-1", "F1MI99-1", "F1MP34-1", "F1MGK5-1", "F1MEZ2-1", "F1MQM7-1", "E1BEZ8-1", "A0A3Q1M0B4-1", "A0AAA9S7W5-1", "A0A3Q1N8V6-1", "A0AAA9TFV5-1", "A0A3Q1MBB1-1", "F1MTZ3-1", "A0AAF6Z8C2-1", "F1MDF1-1", "A0AAA9T5N9-1", "E1BKT4-1", "A0A3Q1MH98-1", "F1N6L3-1", "F1MW70-1", "F1MXF2-1", "A0AAA9TWD1-1" ], "evidence": [ { "id": "10684", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10684" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUB1", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LUB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUB1" } ] } ] }, { "uniprot_ac": "A0A3Q1LZA9", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1LZA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZA9" } ] } ] }, { "uniprot_ac": "A0A3Q1M0B4", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M0B4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0B4" } ] } ] }, { "uniprot_ac": "A0A3Q1M5K4", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K4" } ] } ] }, { "uniprot_ac": "A0A3Q1M6K1", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1M6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6K1" } ] } ] }, { "uniprot_ac": "A0A3Q1MBB1", "gene_name": "TNS2", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBB1" } ] } ] }, { "uniprot_ac": "A0A3Q1MFX2", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MFX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFX2" } ] } ] }, { "uniprot_ac": "A0A3Q1MH98", "gene_name": "DUSP28", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1MH98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH98" } ] } ] }, { "uniprot_ac": "A0A3Q1N8V6", "gene_name": "LOC101903026", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A3Q1N8V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V6" } ] } ] }, { "uniprot_ac": "A0AAA9RTM1", "gene_name": "DUSP22", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9RTM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTM1" } ] } ] }, { "uniprot_ac": "A0AAA9S7W5", "gene_name": "PTPRV", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S7W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7W5" } ] } ] }, { "uniprot_ac": "A0AAA9S9Q3", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9S9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9Q3" } ] } ] }, { "uniprot_ac": "A0AAA9SEK4", "gene_name": "PTPRE", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9SEK4", "database": "UniProtKB", "url": 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L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9TFV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV5" } ] } ] }, { "uniprot_ac": "A0AAA9THG9", "gene_name": "PTPRK", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9THG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THG9" } ] } ] }, { "uniprot_ac": "A0AAA9TWD1", "gene_name": "PTPN20", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": 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phosphate.", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAA9U0H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLF7", "gene_name": "DUSP7", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0AAF6DLF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLF7" } ] } ] }, { "uniprot_ac": "A0AAF6YUC8", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "sn-glycerol 1-phosphate + H2O = glycerol + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6YUC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YUC8" } ] } ] }, { "uniprot_ac": "A0AAF6Z8C2", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0AAF6Z8C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z8C2" } ] } ] }, { "uniprot_ac": "A2VDT1", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2VDT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDT1" } ] } ] }, { "uniprot_ac": "A5D7P0", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A5D7P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D7P0" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "A7MBD1", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBD1" } ] } ] }, { "uniprot_ac": "A7MBJ4", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A7MBJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBJ4" } ] } ] }, { "uniprot_ac": "E1BDH9", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BDH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDH9" } ] } ] }, { "uniprot_ac": "E1BEZ8", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BEZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEZ8" } ] } ] }, { "uniprot_ac": "E1BFE2", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BFE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFE2" } ] } ] }, { "uniprot_ac": "E1BIH4", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIH4" } ] } ] }, { "uniprot_ac": "E1BIU8", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BIU8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BIU8" } ] } ] }, { "uniprot_ac": "E1BJR7", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BJR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJR7" } ] } ] }, { "uniprot_ac": "E1BKT4", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BKT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKT4" } ] } ] }, { "uniprot_ac": "E1BL76", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BL76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL76" } ] } ] }, { "uniprot_ac": "E1BPA0", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPA0" } ] } ] }, { "uniprot_ac": "E1BPU9", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E1BPU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU9" } ] } ] }, { "uniprot_ac": "F1MD22", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MD22" } ] } ] }, { "uniprot_ac": "F1MDF1", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MDF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDF1" } ] } ] }, { "uniprot_ac": "F1ME76", "gene_name": "DUSP13B", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1ME76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ME76" } ] } ] }, { "uniprot_ac": "F1MEZ2", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MEZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEZ2" } ] } ] }, { "uniprot_ac": "F1MGK4", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK4" } ] } ] }, { "uniprot_ac": "F1MGK5", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MGK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGK5" } ] } ] }, { "uniprot_ac": "F1MI99", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MI99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI99" } ] } ] }, { "uniprot_ac": "F1MM08", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MM08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM08" } ] } ] }, { "uniprot_ac": "F1MP34", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MP34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP34" } ] } ] }, { "uniprot_ac": "F1MQM7", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MQM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQM7" } ] } ] }, { "uniprot_ac": "F1MRH9", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MRH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRH9" } ] } ] }, { "uniprot_ac": "F1MTZ3", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MTZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTZ3" } ] } ] }, { "uniprot_ac": "F1MW70", "gene_name": "DUSP12", "activity": [ { "ec_number": "3.1.3.16", "activity": "O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1MW70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW70" } ] }, { "ec_number": "3.1.3.16", "activity": "", 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As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LRL1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRL1#function" }, { "database": "UniProtKB", "id": "ARBA00059794", "url": "https://www.uniprot.org/uniprotkb/ARBA00059794#function" }, { "database": "UniProtKB", "id": "A0AAA9THW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THW9#function" }, { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5#function" }, { "database": "UniProtKB", "id": "A0AAA9TA78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA78#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIK3C3", "url": "https://www.uniprot.org/uniprotkb/F1MTL5", "locus": { "chromosome": "24", "start_pos": 13877874, "end_pos": 14042334, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000026290", "url": "https://www.ensembl.org/id/ENSBTAG00000026290" } ] } } ], "crossref": [ { "id": "F1MTL5", "url": "https://alphafold.ebi.ac.uk/entry/F1MTL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000026290", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000026290", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00870", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00870", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00896", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00896", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08397", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08397", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000403", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000403", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001263", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001263", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002420", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002420", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008290", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008290", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015433", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015433", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036940", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036940", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LHKFAQY", "url": "https://omabrowser.org/oma/group/LHKFAQY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LRL1", "url": "https://www.orthodb.org/?gene=A0A3Q1LRL1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10048", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10048", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10048:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10048:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00454", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00454", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00613", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00613", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00792", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00792", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-109704", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-109704", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1660514", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660514", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1660516", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660516", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1660517", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660517", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-168138", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-168138", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5668599", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5668599", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "12709", "url": "https://www.rhea-db.org/rhea/12709", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LRL1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LRL1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA17", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA17", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA17-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA17-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA78", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TA78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA78-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THW9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYS6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYS6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTL5-1", "url": "https://www.uniprot.org/uniprotkb/F1MTL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGEAEKFHYVYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFEIVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGRWKPMDVEDSLELLSSQYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQGSVSESVSNSGINSAEIDSSQIITSPLPPVSSPPSASKTKESSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK", "length": 887, "header": "tr|F1MTL5-1|F1MTL5_BOVIN Isoform 1 of Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Bos taurus OX=9913 GN=PIK3C3 PE=3 SV=2 CANONICAL=F1MTL5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LRL1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRL1/entry", "sequence": { "sequence": "MGEAEKFHYVYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINEDGDESSPILTSFEIVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGRWKPMDVEDSLELLSSQYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQGSVSESVSNSGINSAEIDSSQIITSPLPPVSSPPSASKTKESSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK", "length": 855, "header": "tr|A0A3Q1LRL1-1|F1MTL5_BOVIN Computationally mapped isoform of Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Bos taurus OX=9913 GN=PIK3C3 PE=3 SV=1 CANONICAL=F1MTL5-1" }, "locus": { "chromosome": "24", "start_pos": 14042276, "end_pos": 13878223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071254.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071254.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059796.1", "url": "https://www.ensembl.org/id/ENSBTAP00000059796.1" } ] } }, { "isoform_ac": "A0A3Q1MA17-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA17/entry", "sequence": { "sequence": "MGEAEKFHYVYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFEIVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGRWKPMDVEDSLELLSSQYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQGSVSESVSNSGINSAEIDSSQIITSPLPPVSSPPSASKTKESSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRPLYLCFLHPNLLRTEHHVEKAMATHSSTLAWKIPWMEEPGRLQSMGSLRVGHD", "length": 864, "header": "tr|A0A3Q1MA17-1|F1MTL5_BOVIN Computationally mapped isoform of Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Bos taurus OX=9913 GN=PIK3C3 PE=3 SV=1 CANONICAL=F1MTL5-1" }, "locus": { "chromosome": "24", "start_pos": 14042276, "end_pos": 13893781, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077983.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077983.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067430.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067430.1" } ] } }, { "isoform_ac": "A0AAA9TA78-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TA78/entry", "sequence": { "sequence": "MGEAEKFHYVYSCDLDINVQLKIWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFEIVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGRWKPMDVEDSLELLSSQYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQGSVSESVSNSGINSAEIDSSQIITSPLPPVSSPPSASKTKESSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK", "length": 824, "header": "tr|A0AAA9TA78-1|F1MTL5_BOVIN Computationally mapped isoform of Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Bos taurus OX=9913 GN=PIK3C3 PE=3 SV=1 CANONICAL=F1MTL5-1" }, "locus": { "chromosome": "24", "start_pos": 14042276, "end_pos": 13878223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102407.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102407.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095616.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095616.1" } ] } }, { "isoform_ac": "A0AAA9THW9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THW9/entry", "sequence": { "sequence": "MGEAEKFHYVYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFEIVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGRWKPMDVEDSLELLSSQYTNPTVRRYAVARLRQADDESRQSCPTLCDPIDGSPTGSSVPGIVQDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQGSVSESVSNSGINSAEIDSSQIITSPLPPVSSPPSASKTKESSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK", "length": 913, "header": "tr|A0AAA9THW9-1|F1MTL5_BOVIN Computationally mapped isoform of Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Bos taurus OX=9913 GN=PIK3C3 PE=3 SV=1 CANONICAL=F1MTL5-1" }, "locus": { "chromosome": "24", "start_pos": 14042276, "end_pos": 13878223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108971.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108971.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097862.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097862.1" } ] } }, { "isoform_ac": "A0AAA9TYS6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYS6/entry", "sequence": { "sequence": "MGEAEKFHYVYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFEIVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGRWKPMDVEDSLELLSSQYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQGSVSESVSNSGINSAEIDSSQIITSPLPPVSSPPSASKTKESSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGHRYLRRRISQPTLVFLSRESCGQRILVGCHLWGCRESDTTEATYHSCMHWRRKWQPTPVFMPGESQEQRSLVGYSPWGRTVSDTTEAT", "length": 843, "header": "tr|A0AAA9TYS6-1|F1MTL5_BOVIN Computationally mapped isoform of Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Bos taurus OX=9913 GN=PIK3C3 PE=3 SV=1 CANONICAL=F1MTL5-1" }, "locus": { "chromosome": "24", "start_pos": 14042276, "end_pos": 13912937, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093839.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093839.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102660.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102660.1" } ] } }, { "isoform_ac": "F1MTL5-1", "url": "https://www.uniprot.org/uniprotkb/F1MTL5/entry", "sequence": { "sequence": "MGEAEKFHYVYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFEIVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGRWKPMDVEDSLELLSSQYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQGSVSESVSNSGINSAEIDSSQIITSPLPPVSSPPSASKTKESSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK", "length": 887, "header": "tr|F1MTL5-1|F1MTL5_BOVIN Isoform 1 of Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Bos taurus OX=9913 GN=PIK3C3 PE=3 SV=2 CANONICAL=F1MTL5-1" }, "locus": { "chromosome": "24", "start_pos": 14042276, "end_pos": 13878223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037295.6", "url": "https://www.ensembl.org/id/ENSBTAT00000037295.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037130.4", "url": "https://www.ensembl.org/id/ENSBTAP00000037130.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-109704", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-109704", "resource": "Reactome", "description": "PI3K Cascade" }, { "id": "R-BTA-1632852", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632852", "resource": "Reactome", "description": "Macroautophagy" }, { "id": "R-BTA-1660514", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660514", "resource": "Reactome", "description": "Synthesis of PIPs at the Golgi membrane" }, { "id": "R-BTA-1660516", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660516", "resource": "Reactome", "description": "Synthesis of PIPs at the early endosome membrane" }, { "id": "R-BTA-1660517", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660517", "resource": "Reactome", "description": "Synthesis of PIPs at the late endosome membrane" }, { "id": "R-BTA-168138", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-168138", "resource": "Reactome", "description": "Toll Like Receptor 9 (TLR9) Cascade" }, { "id": "R-BTA-5668599", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5668599", "resource": "Reactome", "description": "RHO GTPases Activate NADPH Oxidases" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2UEL4-1", "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3", "gene_name": "PIK3C3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGETEKLYYVYSCDLDMNVQLKIGSLEGKREQKSYKALLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTVSEDQMSRLAKLTKSHRQGHMVKVDWLDRLTFREIEMINEREKRSSNFMYLMIEFRCVKSDDKEYGIVYYEKDGDESSPVLTSSEIVKIPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHFTNPTVRRYAVARLQQADDEDLLMYLLQLVQALKYENFDDIKNGLEPSKRDSQGSMSESMTTSGTNGTEIDSSQIMTPIPPVSSPPLTSKMKEPADNENLDQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHVMKAVQRESGNRKKKNERLQALLADNEKMNLAEMELIPLPLEPQVKIKGIIPEKATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLATEESIQNFFRKHAPSETGPHGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK", "length": 886 }, "evidence": [ { "id": "F1MTL5", "url": "https://omabrowser.org/oma/group/F1MTL5/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1Q9F3-1", "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3", "gene_name": "pik3c3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDTDKFNYVYSCDLDINVQLKIGSLEGKREQKSYKALLEDPMLRFSGLYQESCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLRLPVKYPDLPQSAQVTLTVWDVYGPGRATPVGGTTVTLFGKYGMFRQGMHDLKVWPGVEGDGTEPTSTPGRTSSSLAEDQMGRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFPRVKSGEREYSIVYYEKDADESSPLPTSSDIVKVPDPQMCMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLSSEEQDLVWKFRYYLTTQEKALTKFLKCVNWDLPQEAKQALELLGKWRPMDVEDSLELLSSQFTNPTVRRYAVARLQQADDEDLLMYLLQLVQALKYENFNDIQGGLEPANKRDNQGGLTESSTTGDLDSSQLASAIAVMPSSQKGKEGTDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHDMYLNVMRRFSQALLKGDKSVRVMRSLLASQQTFVDRLVQLMKAVQRESGNRKKKTERLQSLLADNEKVNLSEIEPIPLPLEPQIRIKGIIPETATLFKSALMPAKLIFKTEDGEQYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFVQSVPVAEVLATEGNIQSFFRKYAPNDKGPYGISSEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLSKEMVEGMGGMQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVGALFAAVVEQIHKFAQYWRR", "length": 878 }, "evidence": [ { "id": "F1MTL5", "url": "https://omabrowser.org/oma/group/F1MTL5/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O88763-1", "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3", "gene_name": "Pik3c3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKPFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGRAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNATTRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQASVSESLSSSGVSSADIDSSQIITNPLPPVASPPPASKSKEVSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSETGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK", "length": 887 }, "evidence": [ { "id": "F1MTL5", "url": "https://omabrowser.org/oma/group/F1MTL5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P22543-1", "protein_name": "Phosphatidylinositol 3-kinase VPS34", "gene_name": "VPS34", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSLNNITFCVSQDLDVPLKVKIKSLEGHKPLLKPSQKILNPELMLIGSNVFPSSDLIVSLQVFDKERNRNLTLPIYTPYIPFRNSRTWDYWLTLPIRIKQLTFSSHLRIILWEYNGSKQIPFFNLETSIFNLKDCTLKRGFESLKFRYDVIDHCEVVTDNKDQENLNKYFQGEFTRLPWLDEITISKLRKQRENRTWPQGTFVLNLEFPMLELPVVFIEREIMNTQMNIPTLKNNPGLSTDLREPNRNDPQIKISLGDKYHSTLKFYDPDQPNNDPIEEKYRRLERASKNANLDKQVKPDIKKRDYLNKIINYPPGTKLTAHEKGSIWKYRYYLMNNKKALTKLLQSTNLREESERVEVLELMDSWAEIDIDDALELLGSTFKNLSVRSYAVNRLKKASDKELELYLLQLVEAVCFENLSTFSDKSNSEFTIVDAVSSQKLSGDSMLLSTSHANQKLLKSISSESETSGTESLPIVISPLAEFLIRRALVNPRLGSFFYWYLKSESEDKPYLDQILSSFWSRLDKKSRNILNDQVRLINVLRECCETIKRLKDTTAKKMELLVHLLETKVRPLVKVRPIALPLDPDVLICDVCPETSKVFKSSLSPLKITFKTTLNQPYHLMFKVGDDLRQDQLVVQIISLMNELLKNENVDLKLTPYKILATGPQEGAIEFIPNDTLASILSKYHGILGYLKLHYPDENATLGVQGWVLDNFVKSCAGYCVITYILGVGDRHLDNLLVTPDGHFFHADFGYILGQDPKPFPPLMKLPPQIIEAFGGAESSNYDKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRERFNLNMSEEDATVHFQNLINDSVNALLPIVIDHLHNLAQYWRT", "length": 875 }, "evidence": [ { "id": "F1MTL5", "url": "https://omabrowser.org/oma/group/F1MTL5/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P42339-1", "protein_name": "Phosphatidylinositol 3-kinase VPS34", "gene_name": "VPS34", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGANEFRFFLSCDINSPVTFRIEKLDGNLPVKKSSDSGVVSIAEEKKPELYIECALYIDGAPFGLPMRTRLKTTGPPYCWNELITLSSKYRDLTAHSQLAITVWDVSCGKTEGLIGGATVLLFNSKMQMKSGKQKLRLWQGKEADGSFPTSTPGKVPRHERGELERLEKLMNKYERGQIQSIDWLDRLMLKSLDTIKEQESTKHGSSHLFVVIDFCSFEHRVVFQESGANLFITAPIGSTNEFVTVWDTELGKTNPSENKQLKLARSLDRGIIDRDLKPSNIERKSIQRVLKYPPTRTLSGDERQLLWKFRFSLMSEKRALTKFLRCVEWSDVQEAKQAIQLMYKWEMIDVCDALELLSPLFESEEVRAYAVSVLERADDEELQCYLLQLVQALRFERSDRSCLSQFLVQRALQNIELASFLRWYVAVELHDHVYAKRFYSTYELLEENIIKLPPGVNGEDGYQLWQSLVRQTELTAQLCSITREVRNVRGNTQKKIEKLRQLLGGLLSELTYFEEPIRSPLTPNVLIKGIVAGESSLFKSALHPLRLTFRTPEEGGSCKLIFKKGDDLRQDQLVVQMVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSEHRSITSYLQKFHPDEHAPFGITATCLDTFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFHVDFAFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFHLMAGSTIPDIASDPEKGILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRWAQYWR", "length": 814 }, "evidence": [ { "id": "F1MTL5", "url": "https://omabrowser.org/oma/group/F1MTL5/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P54676-1", "protein_name": "Phosphatidylinositol 3-kinase VPS34-like", "gene_name": "pikE", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MKVSKDFKFYYSRDIPIKYKIKLCTLEGKRNKENAPETVDKWIEKKYLKYSSLYRDTTIDLYITCTLYSDGKQLSTSEHTSYNPFSVSNKWDETIIFPLKHQDLPFDTMIVITIWDIYSPMKKVPIGGTSFNIFGMNKIERKGKHKLLIWQDREGDGEKETTTPGQIQGKDEQYRLEKLKKKYDRKLINHCQWLDKFSLNEIERLSRASESLNKNQIYLTIELPEFELPILFKQQNCPLYIPLSQTQKKSLVLINDIEMDEHPSEQKYHRLNLYDHKDLKPNSTELKGLTDILKQPPNTKVTSKEALLIWRFRYYLTNNKKALTKFLRCVEWSESHQKNEALSIMPKWDPIDIADSLELLSSAFTHKNTIMVRRYAVEILKKADDEELLYYLLQLVQATKYEQFDGNPSDSPLISFLFERSNKNFILGSHFYWYLTVDSVLKSSIFCSHYKTLQELYFRQLDHTDAQRVNAQNKFISRLSLLSVELKAMNITREKKIEKLRIMLAEGEYKDLSDFQPIRLPVNPDIEIIGIVPEKSNIYKSAKSPLGLKLRTTKGEEYGVIFKTGDDLRQDQLIIQLISLMDRLLKKENLDLKLTPYKVLATAEEDGIVEMVNPSEAMASVLSKYDGDILKFFKTHNPDADSPYGIAPEVMDTFVKSCAGYCVITYILGIGDRHLDNLLLTPNGKLFHIDFGYILGKDPKILPPPMKLCKEMVLGMGGENSKHYEKFKQLCCEAYNILRKSSHLILNLFALMVDASIPSISDDKEKSILKVQEKLQLELTDQEASNSLLQLLNDSVTALFPVIIEMAHKWLQYWKA", "length": 816 }, "evidence": [ { "id": "F1MTL5", "url": "https://omabrowser.org/oma/group/F1MTL5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6PF93-1", "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3", "gene_name": "Pik3c3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGSAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNATTRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQTSASESLSNSGVSSGDIDSSQIITNPLPPVASPPPASKAKEVSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSETGPYGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK", "length": 887 }, "evidence": [ { "id": "F1MTL5", "url": "https://omabrowser.org/oma/group/F1MTL5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W1M7-1", "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3", "gene_name": "Pi3K59F", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDQPDDHFRYIHSSSLHERVQIKVGTLEGKKRQPDYEKLLEDPILRFSGLYSEEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGNIHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSKEMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWRK", "length": 949 }, "evidence": [ { "id": "F1MTL5", "url": "https://omabrowser.org/oma/group/F1MTL5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "1-phosphatidylinositol-3-kinase activity", "id": "GO:0016303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016303", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 15, "go_terms": [ { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "autophagosome maturation", "id": "GO:0097352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097352", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "host-mediated activation of viral genome replication", "id": "GO:0044829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044829", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "regulation of macroautophagy", "id": "GO:0016241", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016241", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "early endosome to late endosome transport", "id": "GO:0045022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045022", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "positive regulation of natural killer cell mediated cytotoxicity", "id": "GO:0045954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045954", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "regulation of cytokinesis", "id": "GO:0032465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032465", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "phosphatidylinositol-3-phosphate biosynthetic process", "id": "GO:0036092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036092", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "phosphatidylinositol-mediated signaling", "id": "GO:0048015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048015", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0043491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043491", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "positive regulation of cell maturation", "id": "GO:1903431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903431", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "pexophagy", "id": "GO:0000425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000425", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "autolysosome", "id": "GO:0044754", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044754", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "phagophore assembly site", "id": "GO:0000407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000407", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "phosphatidylinositol 3-kinase complex, class III, type I", "id": "GO:0034271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034271", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" }, { "name": "phosphatidylinositol 3-kinase complex, class III, type II", "id": "GO:0034272", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034272", "evidence": [ { "database": "UniProtKB", "id": "F1MTL5", "url": "https://www.uniprot.org/uniprotkb/F1MTL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 584, "end_pos": 586, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12709", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9THJ4-1", "F1MTL5-1", "P32871-1", "E1BE68-1", "E1BE66-1", "A0ABI0NMT8-1" ], "evidence": [ { "id": "12709", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12709" } ] }, { "id": "R-BTA-109699", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endosome membrane, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P32871-1", "A0A3Q1LUE0-1", "F1MN51-1", "F1MYM3-1", "F1MRU0-1", "F1N339-1", "F1MTL5-1", "F1MNW2-1", "A0AAA9TAT1-1" ], "evidence": [ { "id": "R-BTA-109699", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-109699" } ] }, { "id": "R-BTA-1632857", "name": "ULK1 phosphorylates AMBRA1:BECN1 complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SBK8-1", "A0ABI0NQQ4-1", "F1MTL5-1", "A0AAA9SU81-1" ], "evidence": [ { "id": "R-BTA-1632857", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1632857" } ] }, { "id": "R-BTA-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, early endosome membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-1806200" ], "enzyme_list": [ "E1BE68-1", "F1MTL5-1" ], "evidence": [ { "id": "R-BTA-1675939", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1675939" } ] }, { "id": "R-BTA-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi membrane, cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1806159" ], "enzyme_list": [ "E1BE68-1", "F1MTL5-1" ], "evidence": [ { "id": "R-BTA-1675961", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1675961" } ] }, { "id": "R-BTA-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, late endosome membrane", "input_participant_list": [ "R-ALL-1806195" ], "output_participant_list": [ "R-ALL-1806198" ], "enzyme_list": [ "E1BE68-1", "F1MTL5-1" ], "evidence": [ { "id": "R-BTA-1676024", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1676024" } ] }, { "id": "R-BTA-188002", "name": "Rab5-mediated recruitment of class III PI3K to TLR9", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endosome membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MTL5-1" ], "evidence": [ { "id": "R-BTA-188002", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-188002" } ] }, { "id": "R-BTA-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MTL5-1" ], "evidence": [ { "id": "R-BTA-5672012", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5672012" } ] }, { "id": "R-BTA-5678313", "name": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MTL5-1" ], "evidence": [ { "id": "R-BTA-5678313", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5678313" } ] }, { "id": "R-BTA-5678315", "name": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MTL5-1" ], "evidence": [ { "id": "R-BTA-5678315", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5678315" } ] }, { "id": "R-BTA-5679205", "name": "ULK1 phosphorylates Beclin-1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9SBK8-1", "A0ABI0NQQ4-1", "F1MTL5-1", "A0AAA9SU81-1" ], "evidence": [ { "id": "R-BTA-5679205", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5679205" } ] }, { "id": "R-BTA-5679266", "name": "Beclin-1 complex translocates to the ER", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MTL5-1" ], "evidence": [ { "id": "R-BTA-5679266", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5679266" } ] }, { "id": "R-BTA-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endoplasmic reticulum membrane, phagophore assembly site membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MTL5-1" ], "evidence": [ { "id": "R-BTA-5682385", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5682385" } ] }, { "id": "R-BTA-5682388", "name": "Autophagosome maturation", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "autophagosome membrane, phagophore assembly site membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MTL5-1" ], "evidence": [ { "id": "R-BTA-5682388", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5682388" } ] }, { "id": "R-BTA-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, phagocytic vesicle membrane", "input_participant_list": [ "R-ALL-1524165" ], "output_participant_list": [ "R-ALL-1629751" ], "enzyme_list": [ "F1MTL5-1" ], "evidence": [ { "id": "R-BTA-6798174", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6798174" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1524165", "participant_name": "PI [cytosol]", "crossref": [ { "id": "57880", "database": "ChEBI", "url": "" }, { "id": "C01194", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-1629751", "participant_name": "PI3P [cytosol]", "crossref": [ { "id": "58088", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1806159", "participant_name": "PI3P [Golgi membrane]", "crossref": [ { "id": "58088", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1806195", "participant_name": "PI [late endosome membrane]", "crossref": [ { "id": "57880", "database": "ChEBI", "url": "" }, { "id": "C01194", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-1806198", "participant_name": "PI3P [late endosome membrane]", "crossref": [ { "id": "58088", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1806200", "participant_name": "PI3P [early endosome membrane]", "crossref": [ { "id": "58088", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LUE0", "gene_name": "FGFR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LUE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUE0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A3Q1LUE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUE0" } ] } ] }, { "uniprot_ac": "A0AAA9SBK8", "gene_name": "ULK1", "activity": 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} ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMI9-1", "uniprot_ac": "F1MMI9", "uniprot_id": "F1MMI9_BOVIN", "mass": { "chemical_mass": 36551.0, "monoisotopic_mass": 36551.0 }, "refseq": {}, "gene_names": [ { "name": "TRPT1", "type": "recommended", "evidence": [ { "id": "F1MMI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMI9" } ] } ], "protein_names": [ { "name": "2'-phosphotransferase", 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], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMI9", "url": "https://www.uniprot.org/uniprotkb/F1MMI9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TRPT1", "url": "https://www.uniprot.org/uniprotkb/F1MMI9", "locus": { "chromosome": "29", "start_pos": 42529505, "end_pos": 42534371, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016555", "url": "https://www.ensembl.org/id/ENSBTAG00000016555" } ] } } ], "crossref": [ { "id": "F1MMI9", "url": "https://alphafold.ebi.ac.uk/entry/F1MMI9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016555", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016555", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR002745", "url": 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"Protein Classification" ] }, { "id": "PF01885", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01885", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "23324", "url": "https://www.rhea-db.org/rhea/23324", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TCD3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TCD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCD3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMI9", "url": "https://www.uniprot.org/uniprotkb/F1MMI9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMI9-1", "url": "https://www.uniprot.org/uniprotkb/F1MMI9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZE9", "url": "https://www.uniprot.org/uniprotkb/G3MZE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MZE9-1", "url": "https://www.uniprot.org/uniprotkb/G3MZE9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPLNHPPTPGPRILSPRDHSLDVELSTGTAGTGLIAGDAQQQRLTQGSAPFLGAEMPAPFFLGFSLAGPGAQGPAGSAARHPESVLAMNSSGGRRRETAGPKGRRAHRPPQDQDRDVQLSKALSYALRHGALKLGLPMGADGFVPLDALLQLPQFRSFSAEDVQRVVDTNVKQRFALQPGDPSTGPLIRANQGHSLQVPELELEPLETPQALPLMLVHGTFRQHWPSILLKGLSCRGRTHIHLAPGLPGDPGVISGMRPNCEVAVFINGPLALAADGIPFFRSTNGVILTPGNADGVLPPKYFKEALQLRPTRKPLSLAGNEEKEHQRDSKHSSRGRGMTQQ", "length": 342, "header": "tr|F1MMI9-1|F1MMI9_BOVIN Isoform 1 of 2'-phosphotransferase OS=Bos taurus OX=9913 GN=TRPT1 PE=3 SV=4 CANONICAL=F1MMI9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TCD3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCD3/entry", "sequence": { "sequence": "MPLNHPPTPGPRILSPRDHSLDVELSTGTAGTGLIAGDAQQQRLTQGSAPFLGAEMPAPFFLGFSLAGPGAQGPAGSAARHPESDRDVQLSKALSYALRHGALKLGLPMGADGFVPLDALLQLPQFRSFSAEDVQRVVDTNVKQRFALQPGDPSTGPLIRANQGHSLQVPELELEPLETPQALPLMLVHGTFRQHWPSILLKGLSCRGRTHIHLAPGLPGDPGVISGMRPNCEVAVFINGPLALADGIPFFRSTNGVILTPGNADGVLPPKYFKEALQLRPTRKPLSLAGNEEKEHQRDSKHSSRGRGMTQQ", "length": 312, "header": "tr|A0AAA9TCD3-1|F1MMI9_BOVIN Computationally mapped isoform of 2'-phosphotransferase OS=Bos taurus OX=9913 GN=TRPT1 PE=3 SV=1 CANONICAL=F1MMI9-1" }, "locus": { "chromosome": "29", "start_pos": 42534172, "end_pos": 42529562, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108150.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108150.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096318.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096318.1" } ] } }, { "isoform_ac": "F1MMI9-1", "url": "https://www.uniprot.org/uniprotkb/F1MMI9/entry", "sequence": { "sequence": "MPLNHPPTPGPRILSPRDHSLDVELSTGTAGTGLIAGDAQQQRLTQGSAPFLGAEMPAPFFLGFSLAGPGAQGPAGSAARHPESVLAMNSSGGRRRETAGPKGRRAHRPPQDQDRDVQLSKALSYALRHGALKLGLPMGADGFVPLDALLQLPQFRSFSAEDVQRVVDTNVKQRFALQPGDPSTGPLIRANQGHSLQVPELELEPLETPQALPLMLVHGTFRQHWPSILLKGLSCRGRTHIHLAPGLPGDPGVISGMRPNCEVAVFINGPLALAADGIPFFRSTNGVILTPGNADGVLPPKYFKEALQLRPTRKPLSLAGNEEKEHQRDSKHSSRGRGMTQQ", "length": 342, "header": "tr|F1MMI9-1|F1MMI9_BOVIN Isoform 1 of 2'-phosphotransferase OS=Bos taurus OX=9913 GN=TRPT1 PE=3 SV=4 CANONICAL=F1MMI9-1" }, "locus": { "chromosome": "29", "start_pos": 42534172, "end_pos": 42529562, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022022.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022022.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022022.7", "url": "https://www.ensembl.org/id/ENSBTAP00000022022.7" } ] } }, { "isoform_ac": "G3MZE9-1", "url": "https://www.uniprot.org/uniprotkb/G3MZE9/entry", "sequence": { "sequence": "MNSSGGRRRETAGPKGRRAHRPPQDQDRDVQLSKALSYALRHGALKLGLPMGADGFVPLDALLQLPQFRSFSAEDVQRVVDTNVKQRFALQPGDPSTGPLIRANQGHSLQVPELELEPLETPQALPLMLVHGTFRQHWPSILLKGLSCRGRTHIHLAPGLPGDPGVISGMRPNCEVAVFINGPLALAGKPLSLAGNEEKEHQRDSKHSSRGRGMTQQ", "length": 217, "header": "tr|G3MZE9-1|F1MMI9_BOVIN Computationally mapped isoform of 2'-phosphotransferase OS=Bos taurus OX=9913 GN=TRPT1 PE=3 SV=2 CANONICAL=F1MMI9-1" }, "locus": { "chromosome": "29", "start_pos": 42531614, "end_pos": 42529562, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000063145.3", "url": "https://www.ensembl.org/id/ENSBTAT00000063145.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000054946.2", "url": "https://www.ensembl.org/id/ENSBTAP00000054946.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 8, "start_aa": "Thr", "end_pos": 8, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr8", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "tRNA 2'-phosphotransferase activity", "id": "GO:0000215", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000215", "evidence": [ { "database": "UniProtKB", "id": "F1MMI9", "url": "https://www.uniprot.org/uniprotkb/F1MMI9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "tRNA splicing, via endonucleolytic cleavage and ligation", "id": "GO:0006388", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006388", "evidence": [ { "database": "UniProtKB", "id": "F1MMI9", "url": "https://www.uniprot.org/uniprotkb/F1MMI9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "23324", "name": "", "equation": "2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3ZBM7-1", "F1MMI9-1" ], "evidence": [ { "id": "23324", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23324" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MMI9", "gene_name": "TRPT1", "activity": [ { "ec_number": "2.7.1.160", "activity": "2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 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"ENSBTAG00000014151", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014151", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512205", "url": "https://www.ncbi.nlm.nih.gov/gene/512205", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR007850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QEGAETH", "url": "https://omabrowser.org/oma/group/QEGAETH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LUH0", "url": "https://www.orthodb.org/?gene=A0A3Q1LUH0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MNR3", "url": "https://www.orthodb.org/?gene=A0A3Q1MNR3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUH0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUH0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNR3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MNR3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRA9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MRA9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU50", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SU50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU50-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXA5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXA5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXA5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMB8", "url": "https://www.uniprot.org/uniprotkb/F1MMB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMB8-1", "url": "https://www.uniprot.org/uniprotkb/F1MMB8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEERPAQTNAIVDDSAPPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPSKVELGQNGEEKSLPSANHPPKVKVKSSPLIEKLQANLVFDPAALLPGASPKSPGFKAMVSPFHSPPSTPSSPGVRSRPSEPEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGEFRAVEPSQENGAKEESGDEVFPAKSKAPGSPPLRRTSSRTEKLEEKSRAVGEAQEPEKIAGGSEEGAGQHPARASSSEAEDGCGSPKEERPAGEQAEEPTEVKERVASEEEEPRQSSQDTKELEEGAVEEEPPQPPPGGGAGGHSPEQGTSEEKQDEGASLKPGCSPNSGAHAQPDTSSEVPRTEDNTPVQDTKM", "length": 381, "header": "tr|F1MMB8-1|F1MMB8_BOVIN Isoform 1 of RCSD domain containing 1 OS=Bos taurus OX=9913 GN=RCSD1 PE=4 SV=1 CANONICAL=F1MMB8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUH0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUH0/entry", "sequence": { "sequence": "MEERPAQTNAIVDDSAPPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPSKVELGQNGEEANLVFDPAALLPGASPKSPGFKAMVSPFHSPPSTPSSPGVRSRPSEPEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGEFRAVEPSQENGAKEESGDEVFPAKSKAPGSPPLRRTSSRTEKLEEKSRAVGEAQEPEKIAGGSEEGAGQHPARASSSEAEDGCGSPKEERPAGEQAEEPTEVKERVASEEEEPRQSSQDTKELEEGAVEEEPPQPPPGGGAGGHSPEQGTSEEKQDEGASLKPGCSPNSGAHAQPDTSSEVPRTEDNTPVQDTKM", "length": 357, "header": "tr|A0A3Q1LUH0-1|F1MMB8_BOVIN Computationally mapped isoform of RCSD domain containing 1 OS=Bos taurus OX=9913 GN=RCSD1 PE=4 SV=1 CANONICAL=F1MMB8-1" }, "locus": { "chromosome": "3", "start_pos": 1082836, "end_pos": 1013037, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074622.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074622.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060994.1", "url": "https://www.ensembl.org/id/ENSBTAP00000060994.1" } ] } }, { "isoform_ac": "A0A3Q1MNR3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNR3/entry", "sequence": { "sequence": "MQKPAQTNAIVDDSAPPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPSKVELGQNGEEKSLPSANHPPKVKVKSSPLIEKLQANLVFDPAALLPGASPKSPGFKAMVSPFHSPPSTPSSPGVRSRPSEPEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGEFRAVEPSQENGAKEESGDEVFPAKSKAPGSPPLRRTSSRTEKLEEKSRAVGEAQEPEKIAGGSEEGAGQHPARASSSEAEDGCGSPKEERPAGEQAEEPTEVKERVASEEEEPRQSSQDTKELEEGAVEEEPPQPPPGGGAGGHSPEQGTSEEKQDEGASLKPGCSPNSGAHAQIKNFNISYTPIKNKMK", "length": 375, "header": "tr|A0A3Q1MNR3-1|F1MMB8_BOVIN Computationally mapped isoform of RCSD domain containing 1 OS=Bos taurus OX=9913 GN=RCSD1 PE=4 SV=2 CANONICAL=F1MMB8-1" }, "locus": { "chromosome": "3", "start_pos": 1032205, "end_pos": 1017705, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071821.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071821.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072916.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072916.2" } ] } }, { "isoform_ac": "A0A3Q1MRA9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRA9/entry", "sequence": { "sequence": "MEERPAQTNAIVDDSAPPSVAQLAGRFREQAAAAKEKSLPSANHPPKVKVKSSPLIEKLQANLVFDPAALLPGASPKSPGFKAMVSPFHSPPSTPSSPGVRSRPSEPEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGEFRAVEPSQENGAKEESGDEVFPAKSKAPGSPPLRRTSSRTEKLEEKSRAVGEAQEPEKIAGGSEEGAGQHPARASSSEAEDGCGSPKEERPAGEQAEEPTEVKERVASEEEEPRQSSQDTKELEEGAVEEEPPQPPPGGGAGGHSPEQGTSEEKQDEGASLKPGCSPNSGAHAQPDTSSEVPRTEDNTPVQDTKM", "length": 351, "header": "tr|A0A3Q1MRA9-1|F1MMB8_BOVIN Computationally mapped isoform of RCSD domain containing 1 OS=Bos taurus OX=9913 GN=RCSD1 PE=4 SV=1 CANONICAL=F1MMB8-1" }, "locus": { "chromosome": "3", "start_pos": 1082836, "end_pos": 1013037, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079750.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079750.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056905.1", "url": "https://www.ensembl.org/id/ENSBTAP00000056905.1" } ] } }, { "isoform_ac": "A0AAA9SU50-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU50/entry", "sequence": { "sequence": "MERPAQTNAIVDDSAPPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPSKVELGQNGEEKSLPSANHPPKVKVKSSPLIEKLQANLVFDPAALLPGASPKSPGFKAMVSPFHSPPSTPSSPGVRSRPSEPEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGEFRAVEPSQENGAKEESGDEVFPAKSKAPGSPPLRRTSSRTEKLEEKSRAVGEAQEPEKIAGGSEEGAGQHPARASSSEAEDGCGSPKEERPAGEQAEEPTEVKERVASEEEEPRQSSQDTKELEEGAVEEEPPQPPPGGGAGGHSPEQGTSEEKQDEGASLKPGCSPNSGAHAQPDTSSEVPRTEDNTPVQDTKM", "length": 380, "header": "tr|A0AAA9SU50-1|F1MMB8_BOVIN Computationally mapped isoform of RCSD domain containing 1 OS=Bos taurus OX=9913 GN=RCSD1 PE=4 SV=1 CANONICAL=F1MMB8-1" }, "locus": { "chromosome": "3", "start_pos": 1075321, "end_pos": 1013037, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101303.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101303.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089953.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089953.1" } ] } }, { "isoform_ac": "A0AAA9TXA5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXA5/entry", "sequence": { "sequence": "MRPLKFAEVGYLPKDQSEDMNKHSVSGALSERPAQTNAIVDDSAPPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPSKVELGQNGEEKSLPSANHPPKVKVKSSPLIEKLQANLVFDPAALLPGASPKSPGFKAMVSPFHSPPSTPSSPGVRSRPSEPEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGEFRAVEPSQENGAKEESGDEVFPAKSKAPGSPPLRRTSSRTEKLEEKSRAVGEAQEPEKIAGGSEEGAGQHPARASSSEAEDGCGSPKEERPAGEQAEEPTEVKERVASEEEEPRQSSQDTKELEEGAVEEEPPQPPPGGGAGGHSPEQGTSEEKQDEGASLKPGCSPNSGAHAQPDTSSEVPRTEDNTPVQDTKM", "length": 409, "header": "tr|A0AAA9TXA5-1|F1MMB8_BOVIN Computationally mapped isoform of RCSD domain containing 1 OS=Bos taurus OX=9913 GN=RCSD1 PE=4 SV=1 CANONICAL=F1MMB8-1" }, "locus": { "chromosome": "3", "start_pos": 1051897, "end_pos": 1013037, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127234.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127234.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101276.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101276.1" } ] } }, { "isoform_ac": "F1MMB8-1", "url": "https://www.uniprot.org/uniprotkb/F1MMB8/entry", "sequence": { "sequence": "MEERPAQTNAIVDDSAPPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPSKVELGQNGEEKSLPSANHPPKVKVKSSPLIEKLQANLVFDPAALLPGASPKSPGFKAMVSPFHSPPSTPSSPGVRSRPSEPEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGEFRAVEPSQENGAKEESGDEVFPAKSKAPGSPPLRRTSSRTEKLEEKSRAVGEAQEPEKIAGGSEEGAGQHPARASSSEAEDGCGSPKEERPAGEQAEEPTEVKERVASEEEEPRQSSQDTKELEEGAVEEEPPQPPPGGGAGGHSPEQGTSEEKQDEGASLKPGCSPNSGAHAQPDTSSEVPRTEDNTPVQDTKM", "length": 381, "header": "tr|F1MMB8-1|F1MMB8_BOVIN Isoform 1 of RCSD domain containing 1 OS=Bos taurus OX=9913 GN=RCSD1 PE=4 SV=1 CANONICAL=F1MMB8-1" }, "locus": { "chromosome": "3", "start_pos": 1082836, "end_pos": 1013037, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018808.4", "url": "https://www.ensembl.org/id/ENSBTAT00000018808.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018808.3", "url": "https://www.ensembl.org/id/ENSBTAP00000018808.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 124, "start_aa": "Thr", "end_pos": 124, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr124", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2RF79-1", "protein_name": "RCSD domain containing 1", "gene_name": "RCSD1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEKVSTLDLKAEILLICFVHSLFIEGLELLMLRTRADGAVPQPASRARRRPLALCPPQPNPARAGAERRARIASPGPSERARPPPSRHLEDMEERPAETNANVDDSALPSVAQLAGRFREQAAAAKETPASRPTRRKPPCSLSLFPPKVELGQNGEEKSPPTANHPPKMKVKSSPLIEKLQANLAFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRASEPEEPPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGDLGDFRAVESSQENGAKEENGDEVFPAKGKAPGSPPQSRMSSRTEKPEEKGRAAEKAQQPEKAMGNSEEGAGQRPAQASSPEREDASGSPTEEKPAGGQTEEPSEVKEKAASGEEEPGQRGPDTKGPEEGAGAEETPKKSLPGEVEGGHSSEQETSMEKQDEGTGLEPGCNPGTSHTQPDTSSEVLKTEVGVQRVKNPTSIYEDASSIPGLDQWVKDPALP", "length": 494 }, "evidence": [ { "id": "F1MMB8", "url": "https://omabrowser.org/oma/group/F1MMB8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I5YCC4-1", "protein_name": "RCSD domain containing 1", "gene_name": "Rcsd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYMRPRTLKIAPLSKHLPHREDADNEDQERPSETNSNVDSSAQPSVAQLAGRFREQAAVARETPASKPTRRKPPCSLPLFPPKVELGQNGEEKSPSSTSHPPKIKVKSSPLIEKLQANLAFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGIRSHPGEAEEVPVSFDQPPEGTHLPSYNKVRTRGSIKRRPPSRRFRRSQSDCGDLRDYRAVEPSQENGAREENGDDVFPSKSKDPGSPQPNQEAGADRVEGTLRSTEKPRRRNTCSSTEKPEELVGTLEEANAGAKAGQTPDTASQGHPEVQEPSQTCSPETENGCGSPREETAPGEHTDTGKATEGTASEERVTEEEDGLGQKSPDANIPEDEVVRGKVPQTSSGEAEGTTVPEPEAKQKEEAPLEPSGSPGADHSAGEASNEIQSENAVSTEDIPVEDTRM", "length": 438 }, "evidence": [ { "id": "F1MMB8", "url": "https://omabrowser.org/oma/group/F1MMB8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3UZA1-1", "protein_name": "CapZ-interacting protein", "gene_name": "Rcsd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEERPSETNSNVDSSAQPSVAQLAGRFREHAAVARETPASKPTRRKPPCSLPLFPPKVELGQNGEEKSPSGASHPPKIKVKSSPLIEKLQANLAFDPAALLPGASPKSPGLKAIVSPFHSPPSTPSSPGIRSHPSEAEEVPVSFDQPPEGTHLPSYNKVRTRGSIKRRPPSRRFRRSQSDCGDFRDYRAVEPSQENGAREENGDDVFASKSKDPGSPQLNQEAMADGVEGTPWSAEKPRRRNTCNSTEKPEELVRTPEEANAGEKVGQNPDTASQGHPEVQAPSQTGSPEAENGCGSPREETTPGEHTDTGKATEGTASEERVADEDRLGQKSPDANMPEEEGVVREKAPQTSSGKAEGTTIAEPDTKQKEEAPLEPSCSPGADHAAGEITSEIQNEKAVSMDDIPIEDTRM", "length": 412 }, "evidence": [ { "id": "F1MMB8", "url": "https://omabrowser.org/oma/group/F1MMB8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6JBY9-1", "protein_name": "CapZ-interacting protein", "gene_name": "RCSD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTPVQDTKM", "length": 416 }, "evidence": [ { "id": "F1MMB8", "url": "https://omabrowser.org/oma/group/F1MMB8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "F1MMB8", "url": "https://www.uniprot.org/uniprotkb/F1MMB8" } ], "pmid": "" }, { "name": "phosphatidylinositol phosphate binding", "id": "GO:1901981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901981", "evidence": [ { "database": "UniProtKB", "id": "F1MMB8", "url": "https://www.uniprot.org/uniprotkb/F1MMB8" } ], "pmid": "" }, { "name": "retromer complex binding", "id": "GO:1905394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905394", "evidence": [ { "database": "UniProtKB", "id": "F1MMB8", "url": "https://www.uniprot.org/uniprotkb/F1MMB8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cellular hyperosmotic response", "id": "GO:0071474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071474", "evidence": [ { "database": "UniProtKB", "id": "F1MMB8", "url": "https://www.uniprot.org/uniprotkb/F1MMB8" } ], "pmid": "" }, { "name": "protein localization to endosome", "id": "GO:0036010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036010", "evidence": [ { "database": "UniProtKB", "id": "F1MMB8", "url": "https://www.uniprot.org/uniprotkb/F1MMB8" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "F1MMB8", "url": "https://www.uniprot.org/uniprotkb/F1MMB8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F1MMB8", "url": "https://www.uniprot.org/uniprotkb/F1MMB8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MMB8", "url": "https://www.uniprot.org/uniprotkb/F1MMB8" } ], "pmid": "" }, { "name": "WASH complex", "id": "GO:0071203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071203", "evidence": [ { "database": "UniProtKB", "id": "F1MMB8", "url": "https://www.uniprot.org/uniprotkb/F1MMB8" } ], "pmid": "" } ] } ] }, 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MSG8-1", "uniprot_ac": "F1MSG8", "uniprot_id": "F1MSG8_BOVIN", "mass": { "chemical_mass": 69185.0, "monoisotopic_mass": 69185.0 }, "refseq": { "ac": "XP_002689442", "name": "rho-related BTB domain-containing protein 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689442" }, "gene_names": [ { "name": "RHOBTB3", "type": "recommended", "evidence": [ { "id": "F1MSG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" } ] }, { "name": "RHOBTB3", "type": "synonym", "evidence": [ { "id": "XP_002689442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689442" } ] } ], "protein_names": [ { "name": "Rho-related BTB domain-containing protein 3", "type": "recommended", "evidence": [ { "id": "F1MSG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG8/entry#names_and_taxonomy" } ] }, { "name": "rho-related BTB domain-containing protein 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_002689442", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689442" } ] } ], "function": [ { "annotation": "Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T5D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D4#function" }, { "database": "UniProtKB", "id": "ARBA00054233", "url": "https://www.uniprot.org/uniprotkb/ARBA00054233#function" }, { "database": "UniProtKB", "id": "A0A3Q1M8J2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8J2#function" }, { "database": "UniProtKB", "id": "A0A3Q1MCR3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCR3#function" }, { "database": "UniProtKB", "id": "A0A3Q1M2K6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2K6#function" }, { "database": "UniProtKB", "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RHOBTB3", "url": "https://www.uniprot.org/uniprotkb/F1MSG8", "locus": { "chromosome": "7", "start_pos": 95121143, "end_pos": 95036403, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004413", "url": "https://www.ensembl.org/id/ENSBTAG00000004413" } ] } } ], "crossref": [ { "id": "F1MSG8", "url": "https://alphafold.ebi.ac.uk/entry/F1MSG8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004413", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004413", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18357", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18357", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18360", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18360", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18532", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18532", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "530930", "url": "https://www.ncbi.nlm.nih.gov/gene/530930", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:530930", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530930", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CACRERD", "url": "https://omabrowser.org/oma/group/CACRERD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M0T0", "url": "https://www.orthodb.org/?gene=A0A3Q1M0T0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2K6", "url": "https://www.orthodb.org/?gene=A0A3Q1M2K6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M8J2", "url": "https://www.orthodb.org/?gene=A0A3Q1M8J2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MCR3", "url": "https://www.orthodb.org/?gene=A0A3Q1MCR3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MSG8", "url": "https://www.orthodb.org/?gene=F1MSG8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24413", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24413", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9706019", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9706019", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002689442", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689442", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0T0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0T0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0T0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0T0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2K6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2K6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2K6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2K6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8J2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8J2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M8J2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8J2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCR3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MCR3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5D4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5D4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSG8-1", "url": "https://www.uniprot.org/uniprotkb/F1MSG8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSIHIVALGNEGDAFHQDSRPSGLIRAYLGRSPLVSGDESSLLLSASGAAARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKRRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNADLNNLLFCCQCVDVVFYSPDLKEVAEAHKIVLCAVSHVFMLLFSVKSPADIQDSSIIQTTQDLFTINRDPAFPGASQESLGNPPLRVIVKDAFFCSCLSDILRFIYSGAFQWEELEDDIRKKLKDSGDVSNVIEKVKCILKTPGKFNCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSTMYLKQLAEYRKYIHSRKCRCLVM", "length": 611, "header": "tr|F1MSG8-1|F1MSG8_BOVIN Isoform 1 of Rho-related BTB domain-containing protein 3 OS=Bos taurus OX=9913 GN=RHOBTB3 PE=4 SV=3 CANONICAL=F1MSG8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M0T0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0T0/entry", "sequence": { "sequence": "MSIHIVALGNEGDAFHQDSRPSGLIRAYLGRSPLVSGDESSLLLSASGAAARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKRRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNADLNNLLFCCQCVDVVFYSPDLKEVAEAHKIVLCAVSHVFMLLFSVKSPADIQDSSIIQTTQDLFTINRDPAFPGASQESLGNPPLRVIVKDAFFCSCLSDILRFIYSGAFQWEELEDDIRKKLKDSGDVSNVIEKVKCILKTPGKFNCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSTMYLKQLAEYRKYIHSRKCRCLVM", "length": 553, "header": "tr|A0A3Q1M0T0-1|F1MSG8_BOVIN Computationally mapped isoform of Rho-related BTB domain-containing protein 3 OS=Bos taurus OX=9913 GN=RHOBTB3 PE=4 SV=2 CANONICAL=F1MSG8-1" }, "locus": { "chromosome": "7", "start_pos": 95091869, "end_pos": 95036602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086919.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086919.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063597.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063597.2" } ] } }, { "isoform_ac": "A0A3Q1M2K6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2K6/entry", "sequence": { "sequence": "MSIHIVALGNEGDAFHQDSRPSGLIRAYLGRSPLVSGDESSLLLSASGAAARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKRRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNADLNNLLFCCQCVDVVFYSPDLKEVAEAHKIVLCAVSHVFMLLFSVKSPADIQDSSIIQTTQDLFTINRDPAFPGASQESLGNPPLRVIVKDAFFCSCLSDILRFIYSGAFQWEELEDDIRKKLKDSGDVSNVIEKVKCILKTPGKFNCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKATPLAGGGGVGLGLLLEAGGDPWMQKMQNHPFP", "length": 574, "header": "tr|A0A3Q1M2K6-1|F1MSG8_BOVIN Computationally mapped isoform of Rho-related BTB domain-containing protein 3 OS=Bos taurus OX=9913 GN=RHOBTB3 PE=4 SV=2 CANONICAL=F1MSG8-1" }, "locus": { "chromosome": "7", "start_pos": 95120694, "end_pos": 95036602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080085.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080085.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064032.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064032.2" } ] } }, { "isoform_ac": "A0A3Q1M8J2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M8J2/entry", "sequence": { "sequence": "MSIHIVALGNEGDAFHQDSRPSGLIRAYLGRSPLVSGDESSLLLSASGAAARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKRRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNADLNNLLFCCQCVDVVFYSPDLKEVAEAHKIVLCAVSHVFMLLFSVKSPADIQDSSIIQTTQDLFTINRDPAFPGASQESLGNPPLRVIVKDAFFCSCLSDILRFIYSGAFQWEELEDDIRKKLKDSGDVSNVIEKVKCILKTPGKFNCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKWKNAVLLKSTDGHRLCT", "length": 558, "header": "tr|A0A3Q1M8J2-1|F1MSG8_BOVIN Computationally mapped isoform of Rho-related BTB domain-containing protein 3 OS=Bos taurus OX=9913 GN=RHOBTB3 PE=4 SV=2 CANONICAL=F1MSG8-1" }, "locus": { "chromosome": "7", "start_pos": 95091807, "end_pos": 95036602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081328.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081328.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066435.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066435.2" } ] } }, { "isoform_ac": "A0A3Q1MCR3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCR3/entry", "sequence": { "sequence": "MSIHIVALGNEGDAFHQDSRPSGLIRAYLGRSPLVSGDESSLLLSASGAAARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKRRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNADLNNLLFCCQCVDVVFYSPDLKEVAEAHKIVLCAVSHVFMLLFSVKSPADIQDSSIIQTTQDLFTINRDPAFPGASQESLGNPPLRVIVKDAFFCSCLSDILRFIYSGAFQWEELEDDIRKKLKDSGDVSNVIEKVKCILKTPGKFNCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSGHTLGWWRRCGLGPAPGSWR", "length": 593, "header": "tr|A0A3Q1MCR3-1|F1MSG8_BOVIN Computationally mapped isoform of Rho-related BTB domain-containing protein 3 OS=Bos taurus OX=9913 GN=RHOBTB3 PE=4 SV=2 CANONICAL=F1MSG8-1" }, "locus": { "chromosome": "7", "start_pos": 95120654, "end_pos": 95036602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068102.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068102.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066599.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066599.2" } ] } }, { "isoform_ac": "A0AAA9T5D4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5D4/entry", "sequence": { "sequence": "MSIHIVALGNEGDAFHQDSRPSGLIRAYLGRSPLVSGDESSLLLSASGAAARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKRRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNADLNNLLFCCQCVDVVFYSPDLKEVAEAHKIVLCAVSHVFMLLFSVKSPADIQDSSIIQTTQDLFTINRDPAFPGASQESLGNPPLRVIVKDAFFCSCLSDILRFIYSGAFQWEELEDDIRKKLKDSGDVSNVIEKVKCILKTPGKFNCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVGRFGASGPVFRAGHTLEWSMTARVSDMVPQSPLFPDA", "length": 611, "header": "tr|A0AAA9T5D4-1|F1MSG8_BOVIN Computationally mapped isoform of Rho-related BTB domain-containing protein 3 OS=Bos taurus OX=9913 GN=RHOBTB3 PE=4 SV=1 CANONICAL=F1MSG8-1" }, "locus": { "chromosome": "7", "start_pos": 95089020, "end_pos": 95036602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093063.2", "url": "https://www.ensembl.org/id/ENSBTAT00000093063.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093035.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093035.1" } ] } }, { "isoform_ac": "A0AAA9TNZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNZ7/entry", "sequence": { "sequence": "MSIHIVALGNEGDAFHQDSRPSGLIRAYLGRSPLVSGDESSLLLSASGAAARPVFTEYQASAFGNVKLVVHDCPVWVRGLTELSFSFFSPPAPLS", "length": 95, "header": "tr|A0AAA9TNZ7-1|F1MSG8_BOVIN Computationally mapped isoform of Rho-related BTB domain-containing protein 3 OS=Bos taurus OX=9913 GN=RHOBTB3 PE=4 SV=1 CANONICAL=F1MSG8-1" }, "locus": { "chromosome": "7", "start_pos": 95037044, "end_pos": 95036602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124631.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124631.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098950.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098950.1" } ] } }, { "isoform_ac": "F1MSG8-1", "url": "https://www.uniprot.org/uniprotkb/F1MSG8/entry", "sequence": { "sequence": "MSIHIVALGNEGDAFHQDSRPSGLIRAYLGRSPLVSGDESSLLLSASGAAARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKRRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNADLNNLLFCCQCVDVVFYSPDLKEVAEAHKIVLCAVSHVFMLLFSVKSPADIQDSSIIQTTQDLFTINRDPAFPGASQESLGNPPLRVIVKDAFFCSCLSDILRFIYSGAFQWEELEDDIRKKLKDSGDVSNVIEKVKCILKTPGKFNCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSTMYLKQLAEYRKYIHSRKCRCLVM", "length": 611, "header": "tr|F1MSG8-1|F1MSG8_BOVIN Isoform 1 of Rho-related BTB domain-containing protein 3 OS=Bos taurus OX=9913 GN=RHOBTB3 PE=4 SV=3 CANONICAL=F1MSG8-1" }, "locus": { "chromosome": "7", "start_pos": 95091869, "end_pos": 95036602, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005786.8", "url": "https://www.ensembl.org/id/ENSBTAT00000005786.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005786.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005786.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:530930", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:530930", "resource": "KEGG Pathway" }, { "id": "R-BTA-6811440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "resource": "Reactome", "description": "Retrograde transport at the Trans-Golgi-Network" }, { "id": "R-BTA-9706019", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9706019", "resource": "Reactome", "description": "RHOBTB3 ATPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480VGF1-1", "protein_name": "Rho-related BTB domain-containing protein 3", "gene_name": "RHOBTB3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSIHIVALGNEGDAFHQDNRPSGLIRTYLGRSPLVSGDESSLLLNATNTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSDKMKKRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNADLNNLLFCCQCVDVVFYSPDLKDVAEAHKIVLCAVSHVFMLLFNVKSPADIQDSSIIRTTQDLFAINRDPAFPGASQESPGNPPLRVIVKDAVFCSCLSDILRFIYSGAFQWEELEDDIRKKLKDSGDVTNVIEKVKCILKTPGKFNCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM", "length": 611 }, "evidence": [ { "id": "F1MSG8", "url": "https://omabrowser.org/oma/group/F1MSG8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZW90-1", "protein_name": "Rho-related BTB domain-containing protein 3", "gene_name": "Rhobtb3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLLNAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRASNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVTTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKASEKMKKRKMTGSFHGIRPPQLEQPEKMPVLKAEASHYHSDLNNLLLCCQCVDVVFYHPEVMGVVEAHKIVLCSVSHVFMLLFNVKSPNDIQDSSIIRTTQDLFAINRDAVLPGASQESSSNPPLRVIVKDALFCSCLSDILRFIYSGAFQWEELEEDVRRKLKDSGDVSDIIEKVKCILKTPGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGATVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM", "length": 611 }, "evidence": [ { "id": "F1MSG8", "url": "https://omabrowser.org/oma/group/F1MSG8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7EYA0-1", "protein_name": "Rho-related BTB domain-containing protein 3", "gene_name": "rhobtb3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSVHIVALGSECPGGVGPGDETTSSGQIQGGLLWSYLGHGARELDPNSMTPSRHPLNPAFMEYQSRVMGDVRVMVRDCPSWDILDSDWVSVRSILEQADIVVIKYSVNDKLAFQQVRNGYAPRLRPLLRHWGVPVILVAVGARLNDEGPPCTCPLCASDWSSCVPHSEGLQLSRDLGATYLELPSLNNFFVGRYFGSVLEYFMIQCLKQKAKERPDKRRGHRLNEPRPPHLDQPARLPPVRVEESSFSQDLQWLLERGVQFADVAFYAGESGKELGWAHASVLCAVSPYFRQLLVGRQAWERPVSRCTCRDRDGPHSLLSTWDGGVDDLPRADGHPPGHLSRLVVKDPLLCLCLWETLMFLYRGAWEWEYLEEAIAEKLKNPMAVAQLMDRMRSFVGREKAPRDTPTPRSQQGPMTLGSLFNSPLYSDVIFMVQGSVLPAHRAVLVARCDVMAAMFSGKYAEARSRVVPIHGVSSDTFLAFLEYLYTDTCCPASVLQAMAILVCAEMYQVKRLQHLCEVCVCAYLQSMPSRELASTGISVIRLLRRAKCHNADQLYVWLLHFIANNYLIFSHKPDFLELSDEEREQVERLRWPSRGYLQELSEYQQRRRQIRKSRCSIM", "length": 619 }, "evidence": [ { "id": "F1MSG8", "url": "https://omabrowser.org/oma/group/F1MSG8/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3H757-1", "protein_name": "Rho-related BTB domain-containing protein 3", "gene_name": "Rhobtb3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSIHIVALGNEGDTFHQDSRPSGLIRTYLGRSPLVSGDESSLLLNAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSQNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRASNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQTLNQKTSEKMRKRKMTNSFHGIRPPQLEQPEKMPVLKAEASHYHSDLNNLLFCCQCVDVVFYHPEVTGIVEAHKIVLCAVSHVFMLLFNVKSATDIQDSSIIRTTQDLFAVSRDAVFPGASQGSSSNPPLRVIVKDALFCSCLSYILRFIYSGAFQWEELEEDIRRKLKDSGDVSNVIEKVKCILKTPGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM", "length": 611 }, "evidence": [ { "id": "F1MSG8", "url": "https://omabrowser.org/oma/group/F1MSG8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O94955-1", "protein_name": "Rho-related BTB domain-containing protein 3", "gene_name": "RHOBTB3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLLNAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKKRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNSDLNNLLFCCQCVDVVFYNPNLKKVVEAHKIVLCAVSHVFMLLFNVKSPTDIQDSSIIRTTQDLFAINRDTAFPGASHESSGNPPLRVIVKDALFCSCLSDILRFIYSGAFQWEELEEDIRKKLKDSGDVSNVIEKVKCILKTPGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM", "length": 611 }, "evidence": [ { "id": "F1MSG8", "url": "https://omabrowser.org/oma/group/F1MSG8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9CTN4-1", "protein_name": "Rho-related BTB domain-containing protein 3", "gene_name": "Rhobtb3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLLNAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRASNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVTTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKKRKMTSSFHGIRPPQLEQPEKMPVLKAEASHYHSDLNNLLLCCQCVDVVFYHPEVTGVVEAHKIVLCSVSHVFMLLFNVKSPADIQDSSIIRTTQDLFAINRDAVLPGASQEAPSNPPLPVIVKDALFCSCLSDILRFIYSGAFQWEELEEDVRRKLKDSGDVSDIIEKVKCILKTPGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGATVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM", "length": 611 }, "evidence": [ { "id": "F1MSG8", "url": "https://omabrowser.org/oma/group/F1MSG8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" } ], "pmid": "" }, { "name": "regulation of proteolysis", "id": "GO:0030162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030162", "evidence": [ { "database": "UniProtKB", "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "F1MSG8", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MSG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG8" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 254, "end_pos": 356, "start_aa": "Val", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 407, "end_pos": 409 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MS75-1", "uniprot_ac": "F1MS75", "uniprot_id": "F1MS75_BOVIN", "mass": { "chemical_mass": 121105.0, "monoisotopic_mass": 121105.0 }, "refseq": { "ac": "XP_002690982", "name": "solute carrier family 12 member 1 isoform X3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690982" }, "gene_names": [ { "name": "SLC12A1", "type": "recommended", "evidence": [ { "id": "F1MS75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS75" } ] }, { "name": "SLC12A1", "type": "synonym", "evidence": [ { "id": "XP_002690982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690982" } ] } ], "protein_names": [ { "name": "Solute carrier family 12 member 1", "type": "synonym", "evidence": [ { "id": "F1MS75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS75/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 12 member 1 isoform X3", "type": "synonym", "evidence": [ { "id": "XP_002690982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690982" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MS75", "url": "https://www.uniprot.org/uniprotkb/F1MS75" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC12A1", "url": "https://www.uniprot.org/uniprotkb/F1MS75", "locus": { "chromosome": "10", "start_pos": 62095603, "end_pos": 62182460, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010145", "url": "https://www.ensembl.org/id/ENSBTAG00000010145" } ] } } ], "crossref": [ { "id": "F1MS75", "url": "https://alphafold.ebi.ac.uk/entry/F1MS75", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010145", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010145", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "407161", "url": "https://www.ncbi.nlm.nih.gov/gene/407161", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002443", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002443", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013612", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013612", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018491", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018491", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:407161", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407161", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FRIKFAE", "url": "https://omabrowser.org/oma/group/FRIKFAE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11827", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11827:SF93", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF93", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00324", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00324", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03522", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03522", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08403", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08403", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-426117", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-426117", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002690982", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690982", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RWL3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RWL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWL3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSN0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSN0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSN0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1R6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1R6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1R6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1R6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLI8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS75", "url": "https://www.uniprot.org/uniprotkb/F1MS75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS75-1", "url": "https://www.uniprot.org/uniprotkb/F1MS75-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLNNSSNVFLDSTPSNTNRFQVNVINESHESSAAMNDNADPPHYEETSFGDEGQNRFRISFRPGNQECYDNFLQTGETAKTDASFHAYDSHTNTYYLQTFGHNTVDAVPKIEYYRNTGSVSGPKVNRPSLLDIHEQLAKNVSVAPGSADVVANGEGTPGDEQAENKGEDQAGAVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKETDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLIAIANFFIGTVIPSNNEKRARGFFNYQASIFAENFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPKGTMLAIFITTVAYLGVAICVGACVVRDATGSVNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYIYVTYKKPDVNWGSSTQALSYMSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELEKLEQERLALEATIKDNESEEGNGGIRGLFKKAGKLNITKPTPKKDSSINTIQSMHVGEFNQKLVEASTQFKKKQGKGTIDVWWLFDDGGLILLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIAMASLLSKFRIKFADIHVIGDINVKPNKESWKVFEEMIEPYCLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDWLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS", "length": 1099, "header": "tr|F1MS75-1|F1MS75_BOVIN Isoform 1 of Solute carrier family 12 member 1 OS=Bos taurus OX=9913 GN=SLC12A1 PE=3 SV=3 CANONICAL=F1MS75-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RWL3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWL3/entry", "sequence": { "sequence": "MSLNNSSNVFLDSTPSNTNRFQVNVINESHESSAAMNDNADPPHYEETSFGDEGQNRFRISFRPGNQECYDNFLQTGETAKTDASFHAYDSHTNTYYLQTFGHNTVDAVPKIEYYRNTGSVSGPKVNRPSLLDIHEQLAKNVSVAPGSADVVANGEGTPGDEQAENKGEDQAGAVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVIIIGLAVTVTGITGLSTSAIATNGYVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKETDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLIAIANFFIGTVIPSNNEKRARGFFNYQASIFAENFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPKGTMLAIFITTVAYLGVAICVGACVVRDATGSVNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYIYVTYKKPDVNWGSSTQALSYMSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELEKLEQERLALEATIKDNESEEGNGGIRGLFKKAGKLNITKPTPKKDSSINTIQSMHVGEFNQKLVEASTQFKKKQGKGTIDVWWLFDDGGLILLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIAMASLLSKFRIKFADIHVIGDINVKPNKESWKVFEEMIEPYCLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDWLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS", "length": 1099, "header": "tr|A0AAA9RWL3-1|F1MS75_BOVIN Computationally mapped isoform of Solute carrier family 12 member 1 OS=Bos taurus OX=9913 GN=SLC12A1 PE=3 SV=1 CANONICAL=F1MS75-1" }, "locus": { "chromosome": "10", "start_pos": 62180875, "end_pos": 62095620, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096020.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096020.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075494.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075494.1" } ] } }, { "isoform_ac": "A0AAA9SSN0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSN0/entry", "sequence": { "sequence": "MSLNNSSNVFLDSTPSNTNRFQVNVINESHESSAAMNDNADPPHYEETSFGDEGQNRFRISFRPGNQECYDNFLQTGETAKTDASFHAYDSHTNTYYLQTFGHNTVDAVPKIEYYRNTGSVSGPKVNRPSLLDIHEQLAKNVSVAPGSADVVANGEGTPGDEQAENKGEDQAGAVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKETDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLIAIANFFIGTVIPSNNEKRARGFFNYQASIFAENFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPKGTMLAIFITTVAYLGVAICVGACVVRDATGSVNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYIYVTYKKPDVNWGSSTQALSYMSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELEKLEQERLALEATIKDNESEEGNGGIRGLFKKAGKLNITKPTPKKDSSINTIQSMHVGEFNQKLVEASTQFKKKQGKGTIDVWWLFDDGGLILLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIAKCIQERKSLKASVSKFCPVSSGRVKPVNSRQSL", "length": 991, "header": "tr|A0AAA9SSN0-1|F1MS75_BOVIN Computationally mapped isoform of Solute carrier family 12 member 1 OS=Bos taurus OX=9913 GN=SLC12A1 PE=3 SV=1 CANONICAL=F1MS75-1" }, "locus": { "chromosome": "10", "start_pos": 62180875, "end_pos": 62106884, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109899.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109899.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089384.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089384.1" } ] } }, { "isoform_ac": "A0AAA9T1R6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1R6/entry", "sequence": { "sequence": "MSLNNSSNVFLDSTPSNTNRFQVNVINESHESSAAMNDNADPPHYEETSFGDEGQNRFRISFRPGNQECYDNFLQTGETAKTDASFHAYDSHTNTYYLQTFGHNTVDAVPKIEYYRNTGSVSGPKVNRPSLLDIHEQLAKNVSVAPGSADVVANGEGTPGDEQAENKGEDQAGAVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIEYPPLYYWQ", "length": 218, "header": "tr|A0AAA9T1R6-1|F1MS75_BOVIN Computationally mapped isoform of Solute carrier family 12 member 1 OS=Bos taurus OX=9913 GN=SLC12A1 PE=3 SV=1 CANONICAL=F1MS75-1" }, "locus": { "chromosome": "10", "start_pos": 62180875, "end_pos": 62171278, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124027.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124027.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091675.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091675.1" } ] } }, { "isoform_ac": "A0AAA9TLI8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLI8/entry", "sequence": { "sequence": "MSLNNSSNVFLDSTPSNTNRFQVNVINESHESSAAMNDNADPPHYEETSFGDEGQNRFRISFRPGNQECYDNFLQTGETAKTDASFHAYDSHTNTYYLQTFGHNTVDAVPKIEYYRNTGSVSGPKVNRPSLLDIHEQLAKNVSVAPGSADVVANGEGTPGDEQAENKGEDQAGAVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVIIIGLSVVVTTLTGISMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKETDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLIAIANFFIGTVIPSNNEKRARGFFNYQASIFAENFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPKGTMLAIFITTVAYLGVAICVGACVVRDATGSVNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYIYVTYKKPDVNWGSSTQALSYMSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELEKLEQERLALEATIKDNESEEGNGGIRGLFKKAGKLNITKPTPKKDSSINTIQSMHVGEFNQKLVEASTQFKKKQGKGTIDVWWLFDDGGLILLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIAMASLLSKFRIKFADIHVIGDINVKPNKESWKVFEEMIEPYCLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDWLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS", "length": 1099, "header": "tr|A0AAA9TLI8-1|F1MS75_BOVIN Computationally mapped isoform of Solute carrier family 12 member 1 OS=Bos taurus OX=9913 GN=SLC12A1 PE=3 SV=1 CANONICAL=F1MS75-1" }, "locus": { "chromosome": "10", "start_pos": 62180875, "end_pos": 62095620, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132561.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132561.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098075.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098075.1" } ] } }, { "isoform_ac": "F1MS75-1", "url": "https://www.uniprot.org/uniprotkb/F1MS75/entry", "sequence": { "sequence": "MSLNNSSNVFLDSTPSNTNRFQVNVINESHESSAAMNDNADPPHYEETSFGDEGQNRFRISFRPGNQECYDNFLQTGETAKTDASFHAYDSHTNTYYLQTFGHNTVDAVPKIEYYRNTGSVSGPKVNRPSLLDIHEQLAKNVSVAPGSADVVANGEGTPGDEQAENKGEDQAGAVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKETDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLIILLIAIANFFIGTVIPSNNEKRARGFFNYQASIFAENFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPKGTMLAIFITTVAYLGVAICVGACVVRDATGSVNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYIYVTYKKPDVNWGSSTQALSYMSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELEKLEQERLALEATIKDNESEEGNGGIRGLFKKAGKLNITKPTPKKDSSINTIQSMHVGEFNQKLVEASTQFKKKQGKGTIDVWWLFDDGGLILLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIAMASLLSKFRIKFADIHVIGDINVKPNKESWKVFEEMIEPYCLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDWLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS", "length": 1099, "header": "tr|F1MS75-1|F1MS75_BOVIN Isoform 1 of Solute carrier family 12 member 1 OS=Bos taurus OX=9913 GN=SLC12A1 PE=3 SV=3 CANONICAL=F1MS75-1" }, "locus": { "chromosome": "10", "start_pos": 62180875, "end_pos": 62095620, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046583.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046583.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043868.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043868.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:407161", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:407161", "resource": "KEGG Pathway" }, { "id": "R-BTA-426117", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-426117", "resource": "Reactome", "description": "Cation-coupled Chloride cotransporters" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z5P0-1", "protein_name": "Solute carrier family 12 member 1", "gene_name": "SLC12A1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSMNNSPNVFLDPNANRFQVNIINESHNSNEASQEDVESDPPHYEETSFTEEAHNRLRISYRPGKRELYDNFLQNGEKPEASLHPCDTHNKMYYLQTFGHNTMDPVPKIDYYRNTGSVSGNKLNRPSLLEIHEQLAKNIAVSTGSVERVANGESTAGEETAASKEEEKKTGFVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLGVIIILLATMVTSITGLSTSAIATNGFVRGGLGIIVIALSVVVTTLTGISMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVELLKESDTIMVDESNDIRIIGTITVVCLLGISVAGMEWEAKAQVILLIVLLIAIANFFIGTVIPTNNEKKARGFFNYQASIFAENFGPDFRSGEGFFSVFAIFFPAATGILAGANISGDLKDPQGAIPKGTMLAILITTVAYIGVAVCAASCVVRDATGNVNDTVIPGMSCNGSSACNLGYDFSRCRSQPCDYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNVYKGLHFFAKGYGKNNEPIRGYVLTFVIAMAFILIAQLNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAFRYYNMWISLFGALLCCGVMFVINWWAALITYVIELFLYIYVTYKKPEVNWGSSTQALCYIKALDSALALTTVEDHVKNFRPQCIVLTGAPMIRPALLDITHSFTKNNGLCICCEVYTGPRKLCVKEMNSGMAKKQAWLTKNKRKAFYAAVAADSFRDGVKSLLQASGLGRMKPNTLVIGFKKDWRNAAVTQVENYVGVIHDAFDFELGTIIVRIGQGFDISQVLQVQEELEKLEQERLALEATIKENEFDEEKSGICGFFRKARKLNITKHEAKNESTINTVQSMHVGEFNQKLLEASTQFKKKQGKGTIDIWWLFDDGGLTILIPYILTIRKKWKNCKLRIFTGGKVNRIEEEKLVMASLLSKFRIKFADINIICDINMKPNKESWKFFEEMIEPYRLRESCKDITTAEKLKRETPWKITDAELEAFKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGVVSDYLYMAWLEILSKNLPPILMVRGNHKNVLTFYS", "length": 1129 }, "evidence": [ { "id": "F1MS75", "url": "https://omabrowser.org/oma/group/F1MS75/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P55014-1", "protein_name": "Solute carrier family 12 member 1", "gene_name": "Slc12a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVSIPSNSVPSSASRFQVHVINEGHGSAAAVGDSADPPHYEETSFGDEAQNRLRISFRPGNQECYDNFLQTGETAKTDTTFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSVSGPKVNRPSLLEIHEQLAKNVTVAPGSADRVANGDGMPGDEQAENKEEDMTGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGVAICVAACVVRDATGSMNDTIVSGMNCNGSAACGLGYDFSRCQHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNVIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELFLYIYVTYKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISPVLQVQDELEKLEQERLALEAAIKDNECEEGKGGIRGLFKKAGKLNITKPAPKKDGNISSIQSMHVGEFNQKLVEASAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKITRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNKESWKVFEEMIEPYRLHESHKDLTTAEKLKRESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS", "length": 1095 }, "evidence": [ { "id": "F1MS75", "url": "https://omabrowser.org/oma/group/F1MS75/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P55016-1", "protein_name": "Solute carrier family 12 member 1", "gene_name": "Slc12a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVNIPSNSVPSGASRFQVHVINEGHGSGAAMSDSTDPPHYEETSFGDEAQNRLKISFRPGNQECYENFLQTGETAKTDTTFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSVSGPKVNRPSLQEIHEQLAKNVAVAPGSADRVANGDGMPGDEQAENKEEDVTGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVIIIGLSVVVTTLTGISMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGLIFRFANAVRVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIGIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPSFTEGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGVAICVRACVVRDATGSMNDTVVSGMNCNGSAACGLGYDFSRCQHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNVIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELFLYIYVTYKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLMKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISPVLQVQDELEKLEQERLALEAAIKDNDCEEGKGGIRGLFKKAGKLNITKPAPKKDSNISTIQSMHVGEFNQKLVEASAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNKESWKVFEEMIEPYRLHESHKDLTTAEKLKRESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS", "length": 1095 }, "evidence": [ { "id": "F1MS75", "url": "https://omabrowser.org/oma/group/F1MS75/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q13621-1", "protein_name": "Solute carrier family 12 member 1", "gene_name": "SLC12A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPHYEETSFGDEAQKRLRISFRPGNQECYDNFLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS", "length": 1099 }, "evidence": [ { "id": "F1MS75", "url": "https://omabrowser.org/oma/group/F1MS75/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "F1MS75", "url": "https://www.uniprot.org/uniprotkb/F1MS75" } ], "pmid": "" }, { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "F1MS75", "url": "https://www.uniprot.org/uniprotkb/F1MS75" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MS75", "url": "https://www.uniprot.org/uniprotkb/F1MS75" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "cell volume homeostasis", "id": "GO:0006884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006884", "evidence": [ { "database": "UniProtKB", "id": "F1MS75", "url": "https://www.uniprot.org/uniprotkb/F1MS75" } ], "pmid": "" }, { "name": "chloride transmembrane transport", "id": "GO:1902476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902476", "evidence": [ { "database": "UniProtKB", "id": "F1MS75", "url": "https://www.uniprot.org/uniprotkb/F1MS75" } ], "pmid": "" }, { "name": "sodium ion transmembrane transport", "id": "GO:0035725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035725", "evidence": [ { "database": "UniProtKB", "id": "F1MS75", "url": "https://www.uniprot.org/uniprotkb/F1MS75" } ], "pmid": "" }, { "name": "potassium ion homeostasis", "id": "GO:0055075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055075", "evidence": [ { "database": "UniProtKB", "id": "F1MS75", "url": "https://www.uniprot.org/uniprotkb/F1MS75" } ], "pmid": "" }, { "name": "sodium ion homeostasis", "id": "GO:0055078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055078", "evidence": [ { "database": "UniProtKB", "id": "F1MS75", "url": "https://www.uniprot.org/uniprotkb/F1MS75" } ], "pmid": "" }, { "name": "potassium ion import across plasma membrane", "id": "GO:1990573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990573", "evidence": [ { "database": "UniProtKB", "id": "F1MS75", "url": "https://www.uniprot.org/uniprotkb/F1MS75" } ], "pmid": "" }, { "name": "chloride ion homeostasis", "id": "GO:0055064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055064", "evidence": [ { "database": "UniProtKB", "id": "F1MS75", "url": "https://www.uniprot.org/uniprotkb/F1MS75" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "sodium:potassium:chloride symporter activity", "id": "GO:0008511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008511", "evidence": [ { "database": "UniProtKB", "id": "F1MS75", "url": "https://www.uniprot.org/uniprotkb/F1MS75" } ], "pmid": "" }, { "name": "chloride:monoatomic cation symporter activity", "id": "GO:0015377", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015377", "evidence": [ { "database": "UniProtKB", "id": "F1MS75", "url": "https://www.uniprot.org/uniprotkb/F1MS75" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 27, "end_pos": 29, "annotation": "n_glycosylation_sequon" }, { "start_pos": 399, "end_pos": 401, "annotation": "n_glycosylation_sequon" }, { "start_pos": 446, "end_pos": 448, "annotation": "n_glycosylation_sequon" }, { "start_pos": 456, "end_pos": 458, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 848, "end_pos": 850, "annotation": "n_glycosylation_sequon" }, { "start_pos": 868, "end_pos": 870, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MS75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS75" }, { "id": "PF08403", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08403" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amino acid permease N-terminal", "eco_id": "ECO_0000259", "start_pos": 90, "end_pos": 157, "start_aa": "Asp", "end_aa": "Gly", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MS75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS75" }, { "id": "PF00324", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00324" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amino acid permease/ SLC12A", "eco_id": "ECO_0000259", "start_pos": 182, "end_pos": 685, "start_aa": "Gly", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MS75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS75" }, { "id": "PF03522", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03522" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SLC12A transporter C-terminal", "eco_id": "ECO_0000259", "start_pos": 694, "end_pos": 1099, "start_aa": "Arg", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 141, "end_pos": 143 }, { "start_pos": 27, "end_pos": 29 }, { "start_pos": 399, "end_pos": 401 }, { "start_pos": 446, "end_pos": 448 }, { "start_pos": 456, "end_pos": 458 }, { "start_pos": 4, "end_pos": 6 }, { "start_pos": 583, "end_pos": 585 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 848, "end_pos": 850 }, { "start_pos": 868, "end_pos": 870 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MRZ3-1", "uniprot_ac": "F1MRZ3", "uniprot_id": "F1MRZ3_BOVIN", "mass": { "chemical_mass": 112641.0, "monoisotopic_mass": 112641.0 }, "refseq": {}, "gene_names": [ { "name": "ADGRG2", "type": "recommended", "evidence": [ { "id": "F1MRZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3" } ] } ], "protein_names": [ { "name": "Adhesion G-protein coupled receptor G2", "type": "recommended", "evidence": [ { "id": "F1MRZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3/entry#names_and_taxonomy" } ] }, { "name": "G-protein coupled receptor 64", "type": "synonym", "evidence": [ { "id": "F1MRZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MRZ3", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADGRG2", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3", "locus": { "chromosome": "X", "start_pos": 124463135, "end_pos": 124333694, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000576", "url": "https://www.ensembl.org/id/ENSBTAG00000000576" } ] } } ], "crossref": [ { "id": "F1MRZ3", "url": "https://alphafold.ebi.ac.uk/entry/F1MRZ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000576", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000576", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15444", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15444", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100299135", "url": "https://www.ncbi.nlm.nih.gov/gene/100299135", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000203", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000203", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017981", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017981", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046338", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046338", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057244", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057244", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058772", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058772", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058857", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058857", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR12011", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12011", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12011:SF264", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12011:SF264", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00002", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00002", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01825", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01825", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26152", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26152", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26574", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26574", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9RXS3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYC4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYC4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYC4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9G6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9G6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9G6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9G6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNF0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SNF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0J4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0J4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T0J4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0J4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRP1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXZ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TXZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRZ3", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRZ3-1", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVWGSLQLWEVSINPSNWMFFSGGQCGHVGRPEELLLMFKIALVVIFLHITLVTSLEEHAYNSSLLSPSAESSLVDFVPYSNDATSSVLSTLNKTEKTKITIVKTFNASGVKPQRNICNLSSICNNSAFFRGEIMFQYDEESNITQNQVMANGTVTGILSLRELKQSELNKTLETLSETYFTECDAAESQSTVNCTFTIKLNKTMNICAVMVAFQTVKIRPMEQCCCSARTPCPSSLEEVKKLQCDLQDPVECLARHPHGPPFSSSSNAIPVAPPATIVSQISSAFSFAEPLAHPVVTQSPHSPTGVIPLPSPQPSAPITSSPAIDMPLPSGTVSSPKPPPDLPLTLSPGKSSAPSPTTSAPVNVNTTGIPPDKTEIVHTSSISVSDLENQVSRMERALSLGSLEPKLAGQMINQVSRLLHSPPTLLAPLAQRLLKVVDDIGLQLNFSTKTISLTSPSLALAVIRVNASNFDTTTFAAQDPANLQVSLEAQAPENSIGVITLPSSLMRHLPADAVELASRVQFNFFETPALFQDPALENLSLISYVISSSVANLTVKNLTRNVTVTLKHIDPSQDDLTVRCVFWDLGRNGGRGGWSSDGCSVKDRRLNETTCTCSHLTSFGVLLDLSRTSLPPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIALYDIRGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIFGWGIPAVVVAIVLIISPDNYGLGSYGKFPNGSPDDFCWINSNAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKRKKQLGAQRKTSIQDLRSVAGLTFLLGITWGFAFFAWGPVNVTFMYLFAIFNTLQGFFIFVFYCVAKENVRKQWRRYLCCGKLRLAENSDWSKTATNGLKKQTVNQGVSSSSNSLQSNSNSTHSTTLLVNNDCSGLASGNGNASTEKNGVSFSVQNGDVCLHDFTGKQHIFNEKEDSCSGKNRIALRRTSKRGSLHFIEQM", "length": 1028, "header": "tr|F1MRZ3-1|F1MRZ3_BOVIN Isoform 1 of Adhesion G-protein coupled receptor G2 OS=Bos taurus OX=9913 GN=ADGRG2 PE=3 SV=4 CANONICAL=F1MRZ3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXS3/entry", "sequence": { "sequence": "MFFSGGQCGHVGRPEELLLMFKIALVVIFLHITLVTSLEEHAYNSSLLSPSEVETTSLNDATSSVLSTLNKTEKTKITIVKTFNASGVKPQRNICNLSSICNNSAFFRGEIMFQYDEESNITQNQVMANGTVTGILSLRELKQSELNKTLETLSETYFTECDAAESQSTVNCTFTIKLNKTMNICAVMVAFQTVKIRPMEQCCCSARTPCPSSLEEVKKLQCDLQDPVECLARHPHGPPFSSSSNAIPVAPPATIVSQISSAFSFAEPLAHPVVTQSPHSPTGVIPLPSPQPSAPITSSPAIDMPLPSGTVSSPKPPPDLPLTLSPGKSSAPSPTTSAPVNVNTTGIPPDKTEIVHTSSISVSDLENQVSRMERALSLGSLEPKLAGQMINQVSRLLHSPPTLLAPLAQRLLKVVDDIGLQLNFSTKTISLTSPSLALAVIRVNASNFDTTTFAAQDPANLQVSLEAQAPENSIGVITLPSSLMRHLPADAVELASRVQFNFFETPALFQDPALENLSLISYVISSSVANLTVKNLTRNVTVTLKHIDPSQDDLTVRCVFWDLGRNGGRGGWSSDGCSVKDRRLNETTCTCSHLTSFGVLLDLSRTSLPPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIALYDIRGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIFGWGIPAVVVAIVLIISPDNYGLGSYGKFPNGSPDDFCWINSNAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKRKKQLGAQRKTSIQDLRSVAGLTFLLGITWGFAFFAWGPVNVTFMYLFAIFNTLQGFFIFVFYCVAKENVRKQWRRYLCCGKLRLAENSDWSKTATNGLKKQTVNQGVSSSSNSLQSNSNSTHSTTLLVNNDCSGLASGNGNASTEKNGVSFSVQNGDVCLHDFTGKQHIFNEKEDSCSGKNRIALRRTSKRGSLHFIEQM", "length": 1005, "header": "tr|A0AAA9RXS3-1|F1MRZ3_BOVIN Computationally mapped isoform of Adhesion G-protein coupled receptor G2 OS=Bos taurus OX=9913 GN=ADGRG2 PE=3 SV=1 CANONICAL=F1MRZ3-1" }, "locus": { "chromosome": "X", "start_pos": 124462131, "end_pos": 124389911, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131419.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131419.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077366.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077366.1" } ] } }, { "isoform_ac": "A0AAA9RYC4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYC4/entry", "sequence": { "sequence": "MFFSGGQCGHVGRPEELLLMFKIALVVIFLHITLVTSLEEHAYNSSLLSPSAESSLVDFVPYSNGTPEVETTSLNDATSSVLSTLNKTEKTKITIVKTFNASGVKPQRNICNLSSICNNSAFFRGEIMFQYDEESNITQNQVMANGTVTGILSLRELNRQSELNKTLETLSETYFTECDAAESQSTVNCTFTIKLNKTMNICAVMVAFQTVKIRPMEQCCCSARTPCPSSLEEVKKLQCDLQDPVECLARHPHGPPFSSSSNAIPVAPPATIVSQISSAFSFAEPLAHPVVTQSPHSPTGVIPLPSPQPSAPITSSPAIDMPLPSGTVSSPKPPPDLPLTLSPGKSSAPSPTTSAPVNVNTTGIPPDKTEIVHTSSISVSDLENQVSRMERALSLGSLEPKLAGQMINQVSRLLHSPPTLLAPLAQRLLKVVDDIGLQLNFSTKTISLTSPSLALAVIRVNASNFDTTTFAAQDPANLQVSLEAQAPENSIGVITLPSSLMRHLPADAVELASRVQFNFFETPALFQDPALENLSLISYVISSSVANLTVKNLTRNVTVTLKHIDPSQDDLTVRCVFWDLGRNGGRGGWSSDGCSVKDRRLNETTCTCSHLTSFGVLLDLSRTSLPPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIALYDIRGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIFGWGIPAVVVAIVLIISPDNYGLGSYGKFPNGSPDDFCWINSNAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKRKKQLGAQRKTSIQDLRSVAGLTFLLGITWGFAFFAWGPVNVTFMYLFAIFNTLQGFFIFVFYCVAKENVRKQWRRYLCCGKLRLAENSDWSKTATNGLKKQTVNQGVSSSSNSLQSNSNSTHSTTLLVNNDCSGLASGNGNASTEKNGVSFSVQNGDVCLHDFTGKQHIFNEKEDSCSGKNRIALRRTSKRGSLHFIEQM", "length": 1022, "header": "tr|A0AAA9RYC4-1|F1MRZ3_BOVIN Computationally mapped isoform of Adhesion G-protein coupled receptor G2 OS=Bos taurus OX=9913 GN=ADGRG2 PE=3 SV=1 CANONICAL=F1MRZ3-1" }, "locus": { "chromosome": "X", "start_pos": 124462131, "end_pos": 124389911, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133697.2", "url": "https://www.ensembl.org/id/ENSBTAT00000133697.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078561.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078561.1" } ] } }, { "isoform_ac": "A0AAA9S9G6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9G6/entry", "sequence": { "sequence": "MFFSGGQCGHVGRPEELLLMFKIALVVIFLHITLVTSLEEHAYNSSLLSPSAESSLVDFVPYSNGTPEVETTSLNDATSSVLSTLNKTEKTKITIVKTFNASGVKPQRNICNLSSICNNSAFFRGEIMFQYDEESNITQNQVMANGTVTGILSLRELKQSELNKTLETLSETYFTECDAAESQSTVNCTFTIKLNKTMNICAVMVAFQTVKIRPMEQCCCSARTPCPSSLEEVKKLQCDLQDPVECLARHPHGPPFSSSSNAIPVAPPATIVSQISSAFSFAEPLAHPVVTQSPHSPTGVIPLPSPQPSAPITSSPAIDMPLPSGTVSSPKPPPDLPLTLSPGKSSAPSPTTSAPVNVNTTGIPPDKTEIVHTSSISVSDLENQVSRMERALSLGSLEPKLAGQMINQVSRLLHSPPTLLAPLAQRLLKVVDDIGLQLNFSTKTISLTSPSLALAVIRVNASNFDTTTFAAQDPANLQVSLEAQAPENSIGVITLPSSLMRHLPADAVELASRVQFNFFETPALFQDPALENLSLISYVISSSVANLTVKNLTRNVTVTLKHIDPSQDDLTVRCVFWDLGRNGGRGGWSSDGCSVKDRRLNETTCTCSHLTSFGVLLDLSRTSLPPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIALYDIRGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIFGWGIPAVVVAIVLIISPDNYGLGSYGKFPNGSPDDFCWINSNAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKRKKQLGAQRKTSIQDLRSVAGLTFLLGITWGFAFFAWGPVNVTFMYLFAIFNTLQGFFIFVFYCVAKENVRKQWRRYLCCGKLRLAENSGNASTEKNGVSFSVQNGDVCLHDFTGKQHIFNEKEDSCSGKNRIALRRTSKRGSLHFIEQM", "length": 970, "header": "tr|A0AAA9S9G6-1|F1MRZ3_BOVIN Computationally mapped isoform of Adhesion G-protein coupled receptor G2 OS=Bos taurus OX=9913 GN=ADGRG2 PE=3 SV=1 CANONICAL=F1MRZ3-1" }, "locus": { "chromosome": "X", "start_pos": 124462131, "end_pos": 124389911, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105972.2", "url": "https://www.ensembl.org/id/ENSBTAT00000105972.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078777.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078777.1" } ] } }, { "isoform_ac": "A0AAA9SNF0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNF0/entry", "sequence": { "sequence": "MFFSGGQCGHVGRPEELLLMFKIALVVIFLHITLVTSLEEHAYNSSLLSPSAESSLVDFVPYSNGTPEVETTSLNDATSSVLSTLNKTGVKPQRNICNLSSICNNSAFFRGEIMFQYDEESNITQNQVMANGTVTGILSLRELKQSELNKTLETLSETYFTECDAAESQSTVNCTFTIKLNKTMNICAVMVAFQTVKIRPMEQCCCSARTPCPSSLEEVKKLQCDLQDPVECLARHPHGPPFSSSSNAIPVAPPATIVSQISSAFSFAEPLAHPVVTQSPHSPTGVIPLPSPQPSAPITSSPAIDMPLPSGTVSSPKPPPDLPLTLSPGKSSAPSPTTSAPVNVNTTGIPPDKTEIVHTSSISVSDLENQVSRMERALSLGSLEPKLAGQMINQVSRLLHSPPTLLAPLAQRLLKVVDDIGLQLNFSTKTISLTSPSLALAVIRVNASNFDTTTFAAQDPANLQVSLEAQAPENSIGVITLPSSLMRHLPADAVELASRVQFNFFETPALFQDPALENLSLISYVISSSVANLTVKNLTRNVTVTLKHIDPSQDDLTVRCVFWDLGRNGGRGGWSSDGCSVKDRRLNETTCTCSHLTSFGVLLDLSRTSLPPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIALYDIRGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIFGWGIPAVVVAIVLIISPDNYGLGSYGKFPNGSPDDFCWINSNAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKRKKQLGAQRKTSIQDLRSVAGLTFLLGITWGFAFFAWGPVNVTFMYLFAIFNTLQGFFIFVFYCVAKENVRKQWRRYLCCGKLRLAENSDWSKTATNGLKKQTVNQGVSSSSNSLQSNSNSTHSTTLLVNNDCSGLASGNGNASTEKNGVSFSVQNGDVCLHDFTGKQHIFNEKEDSCSGKNRIALRRTSKRGSLHFIEQM", "length": 1007, "header": "tr|A0AAA9SNF0-1|F1MRZ3_BOVIN Computationally mapped isoform of Adhesion G-protein coupled receptor G2 OS=Bos taurus OX=9913 GN=ADGRG2 PE=3 SV=1 CANONICAL=F1MRZ3-1" }, "locus": { "chromosome": "X", "start_pos": 124462131, "end_pos": 124389911, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124920.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124920.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085419.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085419.1" } ] } }, { "isoform_ac": "A0AAA9T0J4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T0J4/entry", "sequence": { "sequence": "MFFSGGQCGHVGRPEELLLMFKIALVVIFLHITLVTSLEEHAYNSSLLSPSAESSLVDFVPYSNGTPDATSSVLSTLNKTEKTKITIVKTFNASGVKPQRNICNLSSICNNSAFFRGEIMFQYDEESNITQNQVMANGTVTGILSLRELNRQSELNKTLETLSETYFTECDAAESQSTVNCTFTIKLNKTMNICAVMVAFQTVKIRPMEQCCCSARTPCPSSLEEVKKLQCDLQDPVECLARHPHGPPFSSSSNAIPVAPPATIVSQISSAFSFAEPLAHPVVTQSPHSPTGVIPLPSPQPSAPITSSPAIDMPLPSGTVSSPKPPPDLPLTLSPGKSSAPSPTTSAPVNVNTTGIPPDKTEIVHTSSISVSDLENQVSRMERALSLGSLEPKLAGQMINQVSRLLHSPPTLLAPLAQRLLKVVDDIGLQLNFSTKTISLTSPSLALAVIRVNASNFDTTTFAAQDPANLQVSLEAQAPENSIGVITLPSSLMRHLPADAVELASRVQFNFFETPALFQDPALENLSLISYVISSSVANLTVKNLTRNVTVTLKHIDPSQDDLTVRCVFWDLGRNGGRGGWSSDGCSVKDRRLNETTCTCSHLTSFGVLLDLSRTSLPPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIALYDIRGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIFGWGIPAVVVAIVLIISPDNYGLGSYGKFPNGSPDDFCWINSNAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKRKKQLGAQRKTSIQDLRSVAGLTFLLGITWGFAFFAWGPVNVTFMYLFAIFNTLQGFFIFVFYCVAKENVRKQWRRYLCCGKLRLAENSDWSKTATNGLKKQTVNQGVSSSSNSLQSNSNSTHSTTLLVNNDCSGLASGNGNASTEKNGVSFSVQNGDVCLHDFTGKQHIFNEKEDSCSGKNRIALRRTSKRGSLHFIEQM", "length": 1014, "header": "tr|A0AAA9T0J4-1|F1MRZ3_BOVIN Computationally mapped isoform of Adhesion G-protein coupled receptor G2 OS=Bos taurus OX=9913 GN=ADGRG2 PE=3 SV=1 CANONICAL=F1MRZ3-1" }, "locus": { "chromosome": "X", "start_pos": 124462131, "end_pos": 124389911, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130272.2", "url": "https://www.ensembl.org/id/ENSBTAT00000130272.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092295.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092295.1" } ] } }, { "isoform_ac": "A0AAA9TRP1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRP1/entry", "sequence": { "sequence": 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Adhesion G-protein coupled receptor G2 OS=Bos taurus OX=9913 GN=ADGRG2 PE=3 SV=1 CANONICAL=F1MRZ3-1" }, "locus": { "chromosome": "X", "start_pos": 124462131, "end_pos": 124389911, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089476.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089476.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101251.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101251.1" } ] } }, { "isoform_ac": "A0AAA9TXZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TXZ3/entry", "sequence": { "sequence": 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"length": 997, "header": "tr|A0AAA9TXZ3-1|F1MRZ3_BOVIN Computationally mapped isoform of Adhesion G-protein coupled receptor G2 OS=Bos taurus OX=9913 GN=ADGRG2 PE=3 SV=1 CANONICAL=F1MRZ3-1" }, "locus": { "chromosome": "X", "start_pos": 124462131, "end_pos": 124389911, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104323.2", "url": "https://www.ensembl.org/id/ENSBTAT00000104323.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101525.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101525.1" } ] } }, { "isoform_ac": "F1MRZ3-1", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3/entry", "sequence": { "sequence": "MVWGSLQLWEVSINPSNWMFFSGGQCGHVGRPEELLLMFKIALVVIFLHITLVTSLEEHAYNSSLLSPSAESSLVDFVPYSNDATSSVLSTLNKTEKTKITIVKTFNASGVKPQRNICNLSSICNNSAFFRGEIMFQYDEESNITQNQVMANGTVTGILSLRELKQSELNKTLETLSETYFTECDAAESQSTVNCTFTIKLNKTMNICAVMVAFQTVKIRPMEQCCCSARTPCPSSLEEVKKLQCDLQDPVECLARHPHGPPFSSSSNAIPVAPPATIVSQISSAFSFAEPLAHPVVTQSPHSPTGVIPLPSPQPSAPITSSPAIDMPLPSGTVSSPKPPPDLPLTLSPGKSSAPSPTTSAPVNVNTTGIPPDKTEIVHTSSISVSDLENQVSRMERALSLGSLEPKLAGQMINQVSRLLHSPPTLLAPLAQRLLKVVDDIGLQLNFSTKTISLTSPSLALAVIRVNASNFDTTTFAAQDPANLQVSLEAQAPENSIGVITLPSSLMRHLPADAVELASRVQFNFFETPALFQDPALENLSLISYVISSSVANLTVKNLTRNVTVTLKHIDPSQDDLTVRCVFWDLGRNGGRGGWSSDGCSVKDRRLNETTCTCSHLTSFGVLLDLSRTSLPPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLLDSWIALYDIRGLCISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIFGWGIPAVVVAIVLIISPDNYGLGSYGKFPNGSPDDFCWINSNAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKRKKQLGAQRKTSIQDLRSVAGLTFLLGITWGFAFFAWGPVNVTFMYLFAIFNTLQGFFIFVFYCVAKENVRKQWRRYLCCGKLRLAENSDWSKTATNGLKKQTVNQGVSSSSNSLQSNSNSTHSTTLLVNNDCSGLASGNGNASTEKNGVSFSVQNGDVCLHDFTGKQHIFNEKEDSCSGKNRIALRRTSKRGSLHFIEQM", "length": 1028, "header": "tr|F1MRZ3-1|F1MRZ3_BOVIN Isoform 1 of Adhesion G-protein coupled receptor G2 OS=Bos taurus OX=9913 GN=ADGRG2 PE=3 SV=4 CANONICAL=F1MRZ3-1" }, "locus": { "chromosome": "X", "start_pos": 124462131, "end_pos": 124375964, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000756.8", "url": "https://www.ensembl.org/id/ENSBTAT00000000756.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000756.7", "url": "https://www.ensembl.org/id/ENSBTAP00000000756.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 358, "start_aa": "Thr", "end_pos": 358, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr358", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MRZ3", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "F1MRZ3", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "F1MRZ3", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3" } ], "pmid": "" }, { "name": "adenylate cyclase-activating G protein-coupled receptor signaling pathway", "id": "GO:0007189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007189", "evidence": [ { "database": "UniProtKB", "id": "F1MRZ3", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3" } ], "pmid": "" }, { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "F1MRZ3", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3" } ], "pmid": "" }, { "name": "phospholipase C-activating G protein-coupled receptor signaling pathway", "id": "GO:0007200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007200", "evidence": [ { "database": "UniProtKB", "id": "F1MRZ3", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "apical plasma membrane", "id": "GO:0016324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "evidence": [ { "database": "UniProtKB", "id": "F1MRZ3", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MRZ3", "url": "https://www.uniprot.org/uniprotkb/F1MRZ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 143, "end_pos": 145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 152, "end_pos": 154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MQC7-1", "uniprot_ac": "F1MQC7", "uniprot_id": "F1MQC7_BOVIN", "mass": { "chemical_mass": 36728.0, "monoisotopic_mass": 36728.0 }, "refseq": { "ac": "NP_001071463", "name": "rhomboid-related protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071463" }, "gene_names": [ { "name": "RHBDD1", "type": "recommended", "evidence": [ { "id": "F1MQC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ] }, { "name": "RHBDD1", "type": "synonym", "evidence": [ { "id": "NP_001071463", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071463" } ] } ], "protein_names": [ { "name": "Rhomboid-related protein 4", "type": "recommended", "evidence": [ { "id": "F1MQC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQC7/entry#names_and_taxonomy" } ] }, { "name": "3.4.21.105", "type": "synonym", "evidence": [ { "id": "F1MQC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQC7/entry#names_and_taxonomy" } ] }, { "name": "Rhomboid domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "F1MQC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQC7/entry#names_and_taxonomy" } ] }, { "name": "Rhomboid-like protein 4", "type": "synonym", "evidence": [ { "id": "F1MQC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQC7/entry#names_and_taxonomy" } ] }, { "name": "rhomboid domain-containing protein 1", "type": "synonym", "evidence": [ { "id": "NP_001071463", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071463" } ] }, { "name": "rhomboid-related protein 4", "type": "synonym", "evidence": [ { "id": "NP_001071463", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071463" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RHBDD1", "url": "https://www.uniprot.org/uniprotkb/F1MQC7", "locus": { "chromosome": "2", "start_pos": 115158251, "end_pos": 115024497, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023963", "url": "https://www.ensembl.org/id/ENSBTAG00000023963" } ] } } ], "crossref": [ { "id": "F1MQC7", "url": "https://alphafold.ebi.ac.uk/entry/F1MQC7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023963", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023963", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533985", "url": "https://www.ncbi.nlm.nih.gov/gene/533985", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022764", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022764", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533985", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533985", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IWFAYII", "url": "https://omabrowser.org/oma/group/IWFAYII/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MQC7", "url": "https://www.orthodb.org/?gene=F1MQC7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F6R7V3", "url": "https://www.orthodb.org/?gene=F6R7V3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43066", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43066", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43066:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43066:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01694", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01694", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071463", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RYP2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6P7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S6P7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF92", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQC7-1", "url": "https://www.uniprot.org/uniprotkb/F1MQC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R7V3", "url": "https://www.uniprot.org/uniprotkb/F6R7V3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6R7V3-1", "url": "https://www.uniprot.org/uniprotkb/F6R7V3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHRRSRGVNIGLLLLLSQIFQVGINNVPPVTLATLALNIWFFLNPLKPLLSSCLSVEKCYYQKDWQRLLLSPLHHADDWHLYFNMVSMLWKGIHLERRLGSRWFAYIIVTFSLLTGVVYLFLEFALAEFLNEPDFKRNCAVGFSGVLFALKVLNNHCCPGGFVNVLGFPVSNRFACWVELLAIHFISPGTSFAGHLAGILVGLMYTHGPLKKIMELCTGIFPSNIDYPGQQYYFNSSGYSGYQDYYPYGGRGAYEDVPRNYDTYTAGLSEEEQLERALRASLLDQGNRRSSPPAYGFRLSPEEEMRRQRLHRFDSQRGDPAL", "length": 322, "header": "tr|F1MQC7-1|F1MQC7_BOVIN Isoform 1 of Rhomboid-related protein 4 OS=Bos taurus OX=9913 GN=RHBDD1 PE=3 SV=1 CANONICAL=F1MQC7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RYP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYP2/entry", "sequence": { "sequence": "MHRRSRGVNIGLLLLLSQIFQVGINNVPPVTLATLALNIWFFLNPLKPLLSSCLSVEKCYYQKDWQRLLLSPLHHADDWHLYFNMVSMLWKGIHLERRLGSRWFAYIIVTFSLLTGVVYLFLEFALAEFLNEPDFKRNCAVGFSGVLFALKVLNNHCCPGGFVNVLGFPVSNRFACWVELLAIHFISPGTSFAGHLAGILVGLMYTHGPLKKIMELCTGIFPSNIDYPGQQYYFNSSGYSGYQDYYPYGGRGAYEDVPRNYDTYTAGLSEEEQLERALRASLLDQEERPIYRKYME", "length": 296, "header": "tr|A0AAA9RYP2-1|F1MQC7_BOVIN Computationally mapped isoform of Rhomboid-related protein 4 OS=Bos taurus OX=9913 GN=RHBDD1 PE=3 SV=1 CANONICAL=F1MQC7-1" }, "locus": { "chromosome": "2", "start_pos": 115105729, "end_pos": 115052607, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099598.1", "url": "https://www.ensembl.org/id/ENSBTAT00000099598.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077735.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077735.1" } ] } }, { "isoform_ac": "A0AAA9S6P7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S6P7/entry", "sequence": { "sequence": "MHRRSRGVNIGLLLLLSQIFQVGINNVPPVTLATLALNIWFFLNPLKPLLSSCLSVEKCYYQKDWQRLLLSPLHHADDWHLYFNMVSMLWKGIHLERRLGSRWFAYIIVTFSLLTGVVYLFLEFALAEFLNEPDFKRNCAVGFSGVLFALKVLNNHCCPGGFVNVLGFPVSNRFACWVELLAIHFISPGTSFAGHLAGILVGLMYTHGPLKKIMELCTGIFPSNIDYPGQQYYFNSSGYSGYQDYYPYGGRGAYEDVPRNYDTYTAGLSEEEQLERALRASLLDQACHQVQLAAGYKAVSFSTSACQPGACVLVKTGNPHDMWSNLCCFS", "length": 330, "header": "tr|A0AAA9S6P7-1|F1MQC7_BOVIN Computationally mapped isoform of Rhomboid-related protein 4 OS=Bos taurus OX=9913 GN=RHBDD1 PE=3 SV=1 CANONICAL=F1MQC7-1" }, "locus": { "chromosome": "2", "start_pos": 115109972, "end_pos": 115052607, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135883.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135883.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078960.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078960.1" } ] } }, { "isoform_ac": "A0AAA9TF92-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF92/entry", "sequence": { "sequence": "MHRRSRGVNIGLLLLLSQIFQVGINNVPPVTLATLALNIWFFLNPLKPLLSSCLSVEKCYYQKDWQRLLLSPLHHADDWHLYFNMVSMLWKGIHLERRLGSRWFAYIIVTFSLLTGVVYLFLEFALAEFLNEPDFKRNCAVGFSGVLFALKVLNNHCCPGGFVNVLGFPVSNRFACWVELLAIHFISPGTSFAGHLAGILVGLMYTHGPLKKIMELCTGIFPSNIDYPGQQYYFNSSGYSGYQDYYPYGGRGAYEDVPRNYDTYTAGLSEEEQLERALRASLLDQALPATTTTAYPPTRHVSKIAAGIMRMLDLQMFIIQKNPFCFFFIIKLLGCQYFMLERQAKFTVQQLQCNALCIICSTPQEQR", "length": 367, "header": "tr|A0AAA9TF92-1|F1MQC7_BOVIN Computationally mapped isoform of Rhomboid-related protein 4 OS=Bos taurus OX=9913 GN=RHBDD1 PE=3 SV=1 CANONICAL=F1MQC7-1" }, "locus": { "chromosome": "2", "start_pos": 115138101, "end_pos": 115052607, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105805.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105805.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095666.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095666.1" } ] } }, { "isoform_ac": "F1MQC7-1", "url": "https://www.uniprot.org/uniprotkb/F1MQC7/entry", "sequence": { "sequence": "MHRRSRGVNIGLLLLLSQIFQVGINNVPPVTLATLALNIWFFLNPLKPLLSSCLSVEKCYYQKDWQRLLLSPLHHADDWHLYFNMVSMLWKGIHLERRLGSRWFAYIIVTFSLLTGVVYLFLEFALAEFLNEPDFKRNCAVGFSGVLFALKVLNNHCCPGGFVNVLGFPVSNRFACWVELLAIHFISPGTSFAGHLAGILVGLMYTHGPLKKIMELCTGIFPSNIDYPGQQYYFNSSGYSGYQDYYPYGGRGAYEDVPRNYDTYTAGLSEEEQLERALRASLLDQGNRRSSPPAYGFRLSPEEEMRRQRLHRFDSQRGDPAL", "length": 322, "header": "tr|F1MQC7-1|F1MQC7_BOVIN Isoform 1 of Rhomboid-related protein 4 OS=Bos taurus OX=9913 GN=RHBDD1 PE=3 SV=1 CANONICAL=F1MQC7-1" }, "locus": { "chromosome": "2", "start_pos": 115157288, "end_pos": 115052607, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032973.5", "url": "https://www.ensembl.org/id/ENSBTAT00000032973.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032900.3", "url": "https://www.ensembl.org/id/ENSBTAP00000032900.3" } ] } }, { "isoform_ac": "F6R7V3-1", "url": "https://www.uniprot.org/uniprotkb/F6R7V3/entry", "sequence": { "sequence": "MHRRSRGVNIGLLLLLSQIFQVGINNVPPVTLATLALNIWFFLNPLKPLLSSCLSVEKCYYQKDWQRLLLSPLHHADDWHLYFNMVSMLWKGIHLERRLGSRWFAYIIVTFSLLTGVVYLFLEFALAEFLNEPDFKRNCAVGFSGVLFALKVLNNHCCPGGFVNVLGFPVSNRFACWVELLAIHFISPGTSFAGHLAGILVGLMYTHGPLKKIMELCTGIFPSNIDYPGQQYYFNSSGYSGYQDYYPYGGRGAYEDVPRNYDTYTAGLSEEEQLERALRASLLDQGNLVKWKREKEKIRRRELRRNQQKQPLSELTCC", "length": 318, "header": "tr|F6R7V3-1|F1MQC7_BOVIN Computationally mapped isoform of Rhomboid-related protein 4 OS=Bos taurus OX=9913 GN=RHBDD1 PE=3 SV=2 CANONICAL=F1MQC7-1" }, "locus": { "chromosome": "2", "start_pos": 115120727, "end_pos": 115052607, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053543.3", "url": "https://www.ensembl.org/id/ENSBTAT00000053543.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048141.3", "url": "https://www.ensembl.org/id/ENSBTAP00000048141.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:533985", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533985", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZX76-1", "protein_name": "Rhomboid-related protein 4", "gene_name": "RHBDD1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQRRQGRVNAGLLLLLYQISQVGLQNIPSVTLAVLILNVFFFLNPMRPLHEACISVKEAFYRQNWQRLLLSPVHHVDDWHLYYNMVSMLWKGIMLERKLGSVWFAYIIAVFSVLTGIVYVLLEFMLVKILNDPSYEMNCGVGFSGVLFALKVLNNHYNPGRVSSVLGLQISSKYACWVELVAIHFIAPRTSFAGHLAGILVGLMYTMGPLKKIMKACAGGFSSFTDPDRPRNDYSGYSEYYRYPDDQYRTPNNYYDYTGGLTEEEQLERAVLNSLNERDFGGATYNNERRPYGFWFPPEQHSEEEMRRQRLRRFWRQ", "length": 317 }, "evidence": [ { "id": "F1MQC7", "url": "https://omabrowser.org/oma/group/F1MQC7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q4V8F3-1", "protein_name": "Rhomboid-related protein 4", "gene_name": "Rhbdd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQRRTRGIDTGLLLLLSQVFHIGINNIPPVTLATLAVNVWFFLNPWKPLYHSCISVEKCYQQNDWQRLLLSPVHHGDDWHLYFNMVSMLWKGVKLEKRLGSRWFAYIIATFSLLTGVVYLLLQFASAELMNQPDFKRNCAVGFSGVLFALKVLSNHYCPGGFVNILGFPVPNRFACWAELAAIHFCTPGTSFAGHLAGILVGLMYTQGPLKKIMDACAGIFISNAGSSGQQYHFNNAGPSGYQNRYTDGRPVNYEATYRNYDIYTAGLSEEEQLERALRASIWDRGNTRNGPIPYGFRLPPEEEMRRQRLHRFDGQ", "length": 316 }, "evidence": [ { "id": "F1MQC7", "url": "https://omabrowser.org/oma/group/F1MQC7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BHC7-1", "protein_name": "Rhomboid-related protein 4", "gene_name": "Rhbdd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQRRTRGINTGLLLLLSQVFQIGINNIPPVTLATLAVNVWFFLNPWKPLYHSCISVEKCYQQKDWQRLLLSPLHHGDDWHLYFNMVSMLWKGVKLERRLGSRWFAYVIATFSLLTGVVYLLLQFTVAELLNQPDFKRNCAVGFSGVLFALKVLSNHYCPGGFVNILGFPVPNRFACWAELVAIHFCTPGTSFAGHLAGILVGLMYTQGPLKKIMDTCAGIFISHAGPSGQQNHFNNAGPSGYQNHYADGRPVTYDATYRNYDVYTAGLSEEEQLERALRASIWDRGNTRNGPMPYGFRLPPEEMRRQRLHRFDGQ", "length": 315 }, "evidence": [ { "id": "F1MQC7", "url": "https://omabrowser.org/oma/group/F1MQC7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TEB9-1", "protein_name": "Rhomboid-related protein 4", "gene_name": "RHBDD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQRRSRGINTGLILLLSQIFHVGINNIPPVTLATLALNIWFFLNPQKPLYSSCLSVEKCYQQKDWQRLLLSPLHHADDWHLYFNMASMLWKGINLERRLGSRWFAYVITAFSVLTGVVYLLLQFAVAEFMDEPDFKRSCAVGFSGVLFALKVLNNHYCPGGFVNILGFPVPNRFACWVELVAIHLFSPGTSFAGHLAGILVGLMYTQGPLKKIMEACAGGFSSSVGYPGRQYYFNSSGSSGYQDYYPHGRPDHYEEAPRNYDTYTAGLSEEEQLERALQASLWDRGNTRNSPPPYGFHLSPEEMRRQRLHRFDSQ", "length": 315 }, "evidence": [ { "id": "F1MQC7", "url": "https://omabrowser.org/oma/group/F1MQC7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 13, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "positive regulation of protein metabolic process", "id": "GO:0051247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051247", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "membrane protein proteolysis", "id": "GO:0033619", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033619", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "cellular response to unfolded protein", "id": "GO:0034620", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034620", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "membrane protein proteolysis involved in retrograde protein transport, ER to cytosol", "id": "GO:1904211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904211", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "post-translational protein modification", "id": "GO:0043687", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043687", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "positive regulation of protein processing", "id": "GO:0010954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010954", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "membrane protein intracellular domain proteolysis", "id": "GO:0031293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031293", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "cellular response to UV", "id": "GO:0034644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034644", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "spermatid differentiation", "id": "GO:0048515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048515", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "endoplasmic reticulum quality control compartment", "id": "GO:0044322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044322", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1MQC7", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MQC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQC7" }, { "id": "PF01694", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01694" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase S54 rhomboid", "eco_id": "ECO_0000259", "start_pos": 63, "end_pos": 206, "start_aa": "Lys", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.21.105", "ec_name": "Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.", "evidence": [ { "id": "3.4.21.105", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.21.105" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 235, "end_pos": 237 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MN54-1", "uniprot_ac": "F1MN54", "uniprot_id": "F1MN54_BOVIN", "mass": { "chemical_mass": 142741.0, "monoisotopic_mass": 142741.0 }, "refseq": {}, "gene_names": [ { "name": "UMODL1", "type": "recommended", "evidence": [ { "id": "F1MN54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN54" } ] } ], "protein_names": [ { "name": "Uromodulin like 1", "type": "synonym", "evidence": [ { "id": "F1MN54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN54/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MN54", "url": "https://www.uniprot.org/uniprotkb/F1MN54" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UMODL1", "url": "https://www.uniprot.org/uniprotkb/F1MN54", "locus": { "chromosome": "1", "start_pos": 142403210, "end_pos": 142327970, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000021270", "url": "https://www.ensembl.org/id/ENSBTAG00000021270" } ] } } ], "crossref": [ { "id": "ENSBTAG00000021270", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000021270", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00199", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00199", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000082", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000082", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008197", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008197", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011489", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011489", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042235", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042235", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048290", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048290", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055355", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055355", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14002", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14002", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14002:SF22", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14002:SF22", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00095", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00095", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00100", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00100", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01390", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01390", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23344", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S333", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S333", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S333-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S333-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN54", "url": "https://www.uniprot.org/uniprotkb/F1MN54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN54-1", "url": "https://www.uniprot.org/uniprotkb/F1MN54-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRTLGMALLALLIIVNLSQASGFTEKGLSLLGFRLCNYSVTQSVQSVKAVQMSRLTRVPCGGWIPLWRCPKTVYQTRYLEVEVPEPRNVTDCCEGYEQLGLYCVLPLNRSQEFASRPGSCPVVGLETSALLCTLDAECPGLQKCCPSSGGHRCSAPAAPAPESNREACWYNVTVVVKMDFKELQQVDPRLLDHMRLLHSMVTSALQPLDTTVHHLHSARGDTSTTVSWLLLGLPRPMPVARVSAVLDGMVKRIYEVIDVQVQDVNECSYGELNTCSGRELCLNVEGSHQCVGYLKSPSSSPPGLDGMCADYPPIRDLMILNVTSSSFQVSWSLNSTQNHTFWVKVYQGEELFRSASTPGTSLEVAGLEAGVRYGVKTSYQACGANITAMVTARTDARVFEVMVRILNHSVTEELLDRGSPEFQDFSQQLMHEVAASLPPAISDLYRRGKLRLQVVSLQSGSVVVRLRLTVWDSEFPVGVSTLAPLLPALWASTVFQVDQQGTRVQDWDECADSLEHDCSPAAQCINLEGSYTCRCRTARDANPSRPGRVCHGDMESPTDVPSPVSEVTASVPSTETTSFSLETPALSPGPGHLWSTPAAGQAWTLGLPPRRGVSGLGSHSGNSTGHSMEKSPPNSTEELPFWPTPAPDPRGHIEWHSSLPVRDTPPAPLDPTWAQNLDPRPFSSPDQPLAPTPAPLKTPACAPVPIGRVTVSNVTSTGFHVAWVADPTLRPTFQLSLVSARSPTMHLQTQKASLTLSGLEPGVLYLVEIVARACGQESAKAQLKVRTVAQKLSGKVSIVNVRYLESFSNTSSEQFQAFLELFLRTVRNSLPAFMLQHLDTGGVRIEVTGISNGSVVVEFTLLVITDVDVWEVSAAFLAAFRNTSLLEVVRDDTFIGDYDECASQEDDCAPGSACRNTLGSFTCSCEGGAPDLLVEFSGRPCEGDSPGNTTQPPGPEQPPTPTGAGAASGQDARPATQGLSPRLNLTGAVRVLCEIEKVAIVIQRHFLQQKGIPESSLYLGQPSCNISDRNSTHVTLAATWSECGTTLQSNMTTTVVRTTLRNDVSPEGIIHHMKIESPIHCAFQNDLLTSSGYTPEWGVYTIIEDLHGAGSFITEMQLFIGDSPIPQNYSVSASDDVKIEVGLYKQKSNLKVVLTECWATPSSDARDPVMFGFINNSCPIPNTHTNVIENGNSNKARFKLKIFSFINNSIVYLHCKLRICMESPGATCKINCDDFRSLRSSEPSVMHQMSWGPLIRSEAGLGLGAGYLVLIVGTACALVAGATALLVRHYQRMIGKYDFKVRTDNFSYQVFHE", "length": 1314, "header": "tr|F1MN54-1|F1MN54_BOVIN Isoform 1 of Uromodulin like 1 OS=Bos taurus OX=9913 GN=UMODL1 PE=4 SV=4 CANONICAL=F1MN54-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S333-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S333/entry", "sequence": { "sequence": "MLRTLGMALLALLIIVNLSQASGFTEKGLSLLGFRLCNYSVTQSVQSVKAVQMSRLTRVPCGGWIPLWRCPKTVYQTRYLEVEVPEPRNVTDCCEGYEQLGLYCVLPLNRSQEFASRPGSCPVVGLETSALLCTLDAECPGLQKCCPSSGGHRCSAPAAPAPESNREACWYNVTVVVKMDFKELQQVDPRLLDHMRLLHSMVTSALQPLDTTVHHLHSARGDTSTTVSWLLLGLPRPMPVARVSAVLDGMVKRIYEVIDVQVQDVNECSYGELNTCSGRELCLNVEGSHQCVGYLKSPSSSPPGLDGMCADYPPIRDLMILNVTSSSFQVSWSLNSTQNHTFWVKVYQGEELFRSASTPGTSLEVAGLEAGVRYGVKTSYQACGANITAMVTARTDARVFEVMVRILNHSVTEELLDRGSPEFQDFSQQLMHEVAASLPPAISDLYRRGKLRLQVVSLQSGSVVVRLRLTVWDSEFPVGVSTLAPLLPALWASTVFQVDQQGTRVQDWDECADSLEHDCSPAAQCINLEGSYTCRCRTARDANPSRPGRVCHGDMESPTDVPSPVSEVTASVPSTETTSFSLETPALSPGPGHLWSTPAAGQAWTLGLPPRRGVSGLGSHSGNSTGHSMEKASVAPGLGTGQWTASRVAFSPRVPGPTHSSSLGATDSLPDTPGQSPPNSTEELPFWPTPAPDPRGHIEWHSSLPVRDTPPAPLDPTWAQNLDPRPFSSPDQPLAPTPAPLKTPACAPVPIGRVTVSNVTSTGFHVAWVADPTLRPTFQLSLVSARSPTMHLQTQKASLTLSGLEPGVLYLVEIVARACGQESAKAQLKVRTVAQKLSGKVSIVNVRYLESFSNTSSEQFQAFLELFLRTVRNSLPAFMLQHLDTGGVRIEVTGISNGSVVVEFTLLVITDVDVWEVSAAFLAAFRNTSLLEVVRDDTFIGDYDECASQEDDCAPGSACRNTLGSFTCSCEGGAPDLLVEFSGRPCEGDSPGNTTQPPGPEQPPTPTGAGAASGQDARPATQGLSPRLNLTGAVRVLCEIEKVAIVIQRHFLQQKGIPESSLYLGQPSCNISDRNSTHVTLAATWSECGTTLQSNMTTTVVRTTLRNDVSPEGIIHHMKIESPIHCAFQNDLLTSSGYTPEWGVYTIIEDLHGAGSFITEMQLFIGDSPIPQNYSVSASDDVKIEVGLYKQKSNLKVVLTECWATPSSDARDPVMFGFINNSCPIPNTHTNVIENGNSNKARFKLKIFSFINNSIVYLHCKLRICMESPGATCKINCDDFRSLRSSEPSVMHQMSWGPLIRSEAGLGLGAGYLVLIVGTACALVAGATALLVRHYQRMIGKYDFKVRTDNFSYQVFHE", "length": 1358, "header": "tr|A0AAA9S333-1|F1MN54_BOVIN Computationally mapped isoform of Uromodulin like 1 OS=Bos taurus OX=9913 GN=UMODL1 PE=4 SV=1 CANONICAL=F1MN54-1" }, "locus": { "chromosome": "1", "start_pos": 142403207, "end_pos": 142327970, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133540.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133540.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080332.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080332.1" } ] } }, { "isoform_ac": "F1MN54-1", "url": "https://www.uniprot.org/uniprotkb/F1MN54/entry", "sequence": { "sequence": 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"PF08916", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08916", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1433559", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1433559", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059737584", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737584", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S8U0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8U0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SST8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SST8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NSC6", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NSC6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSC6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRH8", "url": "https://www.uniprot.org/uniprotkb/F1MRH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRH8-1", "url": "https://www.uniprot.org/uniprotkb/F1MRH8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTGHQWSSAQHSEPASGGCDGTGAMNGAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGASFSRHFAANFLDVFSEEVRRVLVAGPAPPRGAAEPPDAMEPGPAGPPALKAAPYGHSRSSEDVSATAAAKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPGAAEPPAEPRDKWMRRLRLSRTLAAKVQLVDIQREGALRFMVADDAASGPGGAAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTEPSCARGGCLASRVASCSCELLTEAVDLPRPPETTAAVVTAPHSRAREAVGESLVHVPLETFLETLESPGGSGSSSTEEAAEPEAQAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPSPSAAPPPPACWSEPAGQHYFSSLAAAACPPASPSEAGGASSSSASSSSAASVPGAPRPAAEGPLSARSRSNSAERLLEAAGGGAEEPPEAGSGEGARGHTRAVENQYSFY", "length": 648, "header": "tr|F1MRH8-1|F1MRH8_BOVIN Isoform 1 of SH2B adapter protein 2 OS=Bos taurus OX=9913 GN=SH2B2 PE=3 SV=3 CANONICAL=F1MRH8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S8U0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U0/entry", "sequence": { "sequence": "MNLRAARGSAPRQPAGRDRAEAGTPAAHEVLSSAGRASGGCDGTGAMNGAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGASFSRHFAANFLDVFSEEVRRVLVAGPAPPRGAAEPPDAMEPGPAGPPALKAAPYGHSRSSEDVSATAAAKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPGAAEPPAEPRDKWMRRLRLSRTLAAKVQLVDIQREGALRFMVADDAASGPGGAAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTEPSCARGGCLASRVASCSCELLTEVDLPRPPETTAAVVTAPHSRAREAVGESLVHVPLETFLETLESPGGSGSSSTEEAAEPEAQAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPSPSAAPPPPACWSEPAGQHYFSSLAAAACPPASPSEAGGASSSSASSSSAASVPGAPRPAAEGPLSARSRSNSAERLLEAAGGGAEEPPEAGSGEGARGHTRAVENQYSFY", "length": 669, "header": "tr|A0AAA9S8U0-1|F1MRH8_BOVIN Computationally mapped isoform of SH2B adapter protein 2 OS=Bos taurus OX=9913 GN=SH2B2 PE=3 SV=1 CANONICAL=F1MRH8-1" }, "locus": { "chromosome": "25", "start_pos": 34699471, "end_pos": 34677918, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110864.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110864.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079779.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079779.1" } ] } }, { "isoform_ac": "A0AAA9SST8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SST8/entry", "sequence": { "sequence": "MNGAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGASFSRHFAANFLDVFSEEVRRVLVAGPAPPRGAAEPPDAMEPGPAGPPALKAAPYGHSRSSEDVSATAAAKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPGAAEPPAEPRDKWMRRLRLSRTLAAKVQLVDIQREGALRFMVADDAASGPGGAAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTEPSCARGGCLASRVASCSCELLTEAVDLPRPPETTAAVVTAPHSRAREAVGESLVHVPLETFLETLESPGGSGSSSTEEAAEPEAQAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKGLWRLGMDGHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPSPSAAPPPPACWSEPAGQHYFSSLAAAACPPASPSEAGGASSSSASSSSAASVPGAPRPAAEGPLSARSRSNSAERLLEAAGGGAEEPPEAGSGEGARGHTRAVENQYSFY", "length": 633, "header": "tr|A0AAA9SST8-1|F1MRH8_BOVIN Computationally mapped isoform of SH2B adapter protein 2 OS=Bos taurus OX=9913 GN=SH2B2 PE=3 SV=2 CANONICAL=F1MRH8-1" }, "locus": { "chromosome": "25", "start_pos": 34689728, "end_pos": 34677918, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114964.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114964.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089462.2", "url": "https://www.ensembl.org/id/ENSBTAP00000089462.2" } ] } }, { "isoform_ac": "A0ABI0NSC6-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NSC6/entry", "sequence": { "sequence": "MNGAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGASFSRHFAANFLDVFSEEVRRVLVAGPAPPRGAAEPPDAMEPGPAGPPALKAAPYGHSRSSEDVSATAAAKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPGAAEPPAEPRDKWMRRLRLSRTLAAKVQLVDIQREGALRFMVADDAASGPGGAAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTEPSCARGGCLASRVASCSCELLTEAVDLPRPPETTAAVVTAPHSRAREAVGESLVHVPLETFLETLESPGGSGSSSTEEAAEPEAQAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPGPPGSSVHGILQARILEWGCQPSRGSSRPRDRTPVSCICRQVFYRLSHSRLYPRLSLGGGLELGARDLGSEPPCVMLGHPFLGRWPLPARCWGGGGGSAWKEGGPGLRPDARGLPLQTRGPRPAPRPRRLPAGASRPASTTSPVSPRQLALPPRPRRPAAPRPRPPRRLRPLRCPAPPAPPPRAR", "length": 694, "header": "tr|A0ABI0NSC6-1|A0ABI0NSC6_BOVIN Computationally mapped isoform of SH2B adapter protein 2 OS=Bos taurus OX=9913 GN=SH2B2 PE=3 SV=1 CANONICAL=F1MRH8-1" }, "locus": { "chromosome": "25", "start_pos": 34689728, "end_pos": 34678058, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000153430.1", "url": "https://www.ensembl.org/id/ENSBTAT00000153430.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105830.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105830.1" } ] } }, { "isoform_ac": "F1MRH8-1", "url": "https://www.uniprot.org/uniprotkb/F1MRH8/entry", "sequence": { "sequence": "MTGHQWSSAQHSEPASGGCDGTGAMNGAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDAGASFSRHFAANFLDVFSEEVRRVLVAGPAPPRGAAEPPDAMEPGPAGPPALKAAPYGHSRSSEDVSATAAAKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPGAAEPPAEPRDKWMRRLRLSRTLAAKVQLVDIQREGALRFMVADDAASGPGGAAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTEPSCARGGCLASRVASCSCELLTEAVDLPRPPETTAAVVTAPHSRAREAVGESLVHVPLETFLETLESPGGSGSSSTEEAAEPEAQAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPSPSAAPPPPACWSEPAGQHYFSSLAAAACPPASPSEAGGASSSSASSSSAASVPGAPRPAAEGPLSARSRSNSAERLLEAAGGGAEEPPEAGSGEGARGHTRAVENQYSFY", "length": 648, "header": "tr|F1MRH8-1|F1MRH8_BOVIN Isoform 1 of SH2B adapter protein 2 OS=Bos taurus OX=9913 GN=SH2B2 PE=3 SV=3 CANONICAL=F1MRH8-1" }, "locus": { "chromosome": "25", "start_pos": 34702221, "end_pos": 34677918, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012781.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012781.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012781.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012781.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1433559", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1433559", "resource": "Reactome", "description": "Regulation of KIT signaling" }, { "id": "R-BTA-983231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "resource": "Reactome", "description": "Factors involved in megakaryocyte development and platelet production" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MRH8", "url": "https://www.uniprot.org/uniprotkb/F1MRH8" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MRH8", "url": "https://www.uniprot.org/uniprotkb/F1MRH8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MRH8", "url": "https://www.uniprot.org/uniprotkb/F1MRH8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1MRH8", "url": "https://www.uniprot.org/uniprotkb/F1MRH8" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1MRH8", "url": "https://www.uniprot.org/uniprotkb/F1MRH8" } ], "pmid": "" }, { "name": "B cell receptor signaling pathway", "id": "GO:0050853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050853", "evidence": [ { "database": "UniProtKB", "id": "F1MRH8", "url": "https://www.uniprot.org/uniprotkb/F1MRH8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "signaling adaptor activity", "id": "GO:0035591", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035591", "evidence": [ { "database": "UniProtKB", "id": "F1MRH8", "url": "https://www.uniprot.org/uniprotkb/F1MRH8" } ], "pmid": "" }, { "name": "transmembrane receptor protein tyrosine kinase adaptor activity", "id": "GO:0005068", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005068", "evidence": [ { "database": "UniProtKB", "id": "F1MRH8", "url": "https://www.uniprot.org/uniprotkb/F1MRH8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 157, "end_pos": 159, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": 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{ "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMS4-1", "uniprot_ac": "F1MMS4", "uniprot_id": "F1MMS4_BOVIN", "mass": { "chemical_mass": 59922.0, "monoisotopic_mass": 59922.0 }, "refseq": { "ac": "NP_001341392", "name": "telomeric repeat-binding factor 2 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341392" }, "gene_names": [ { "name": "TERF2", "type": "recommended", "evidence": [ { "id": "F1MMS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS4" } ] }, { "name": "TERF2", "type": "synonym", "evidence": [ { "id": "NP_001341392", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341392" } ] } ], "protein_names": [ { "name": "Telomeric repeat-binding factor 2", "type": "recommended", "evidence": [ { "id": "F1MMS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS4/entry#names_and_taxonomy" } ] }, { "name": "TTAGGG repeat binding factor 2", "type": "synonym", "evidence": [ { "id": "NP_001341392", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341392" } ] }, { "name": "TTAGGG repeat-binding factor 2", "type": "synonym", "evidence": [ { "id": "F1MMS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS4/entry#names_and_taxonomy" } ] }, { "name": "Telomeric DNA-binding protein", "type": "synonym", "evidence": [ { "id": "F1MMS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS4/entry#names_and_taxonomy" } ] }, { "name": "telomeric repeat-binding factor 2 isoform 1", "type": "synonym", "evidence": [ { "id": "NP_001341392", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341392" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMS4", "url": "https://www.uniprot.org/uniprotkb/F1MMS4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TERF2", "url": "https://www.uniprot.org/uniprotkb/F1MMS4", "locus": { "chromosome": "18", "start_pos": 36491411, "end_pos": 36514023, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007617", "url": "https://www.ensembl.org/id/ENSBTAG00000007617" } ] } } ], "crossref": [ { "id": "F1MMS4", "url": "https://alphafold.ebi.ac.uk/entry/F1MMS4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007617", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007617", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00280", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00280", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11654", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11654", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11660", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11660", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506501", "url": "https://www.ncbi.nlm.nih.gov/gene/506501", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030657", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030657", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031902", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031902", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506501", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506501", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EKETWME", "url": "https://omabrowser.org/oma/group/EKETWME/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MMS4", "url": "https://www.orthodb.org/?gene=F1MMS4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46833", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46833", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46833:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46833:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00249", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00249", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08558", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08558", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16772", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16772", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-110330", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110330", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-110331", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110331", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-171306", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-171306", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-171319", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-171319", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174411", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174411", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174414", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174414", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174417", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174417", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174430", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174430", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-174437", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174437", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559586", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9670095", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9670095", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001341392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341392", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SI19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMS4", "url": "https://www.uniprot.org/uniprotkb/F1MMS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMS4-1", "url": "https://www.uniprot.org/uniprotkb/F1MMS4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAGAGTAGSASGPGVVRDPAASQSRKRPGREGGEGARRSDAMAGGGGSSDSSGRAAGRRASRSGGRARRGRHAPGLGGAAERGAGEVRLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVIESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMARKALKSESSASATVKEPQPQPAPEPVEKPLREPARQLQSTPTTIGIRTLKAAFKTLSSAQDSEAAFSKLDQKDMVFPNKVCPPSPALKNKRTRKDDNESSAPTEGEGGSELQPKTKRMTISRLVLEEDSQSTEPSSGLDSSQEVTPASPSKPTVLNQPLPGEKNPKVTKGKWNSSNGVEEKETWVEEDELFQVQAAPDEESATNTTKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN", "length": 543, "header": "tr|F1MMS4-1|F1MMS4_BOVIN Isoform 1 of Telomeric repeat-binding factor 2 OS=Bos taurus OX=9913 GN=TERF2 PE=4 SV=3 CANONICAL=F1MMS4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SI19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI19/entry", "sequence": { "sequence": "MAAGAGTAGSASGPGVVRDPAASQSRKRPGREGGEGARRSDAMAGGGGSSDSSGRAAGRRASRSGGRARRGRHAPGLGGAAERGAGEVRLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQGEGRPWGRRLGAPGKGICAHSPRPHVSRLGVAESTMSSFPALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVIESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMARKALKSESSASATVKEPQPQPAPEPVEKPLREPARQLQSTPTTIGIRTLKAAFKTLSSAQDSEAAFSKLDQKDMVFPNKVCPPSPALKNKRTRKDDNESSAPTEGEGGSELQPKTKRMTISRLVLEEDSQSTEPSSGLDSSQEVTPASPSKPTVLNQPLPGEKNPKVTKGKWNSSNGVEEKETWVEEDELFQVQAAPDEESATNTTKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN", "length": 583, "header": "tr|A0AAA9SI19-1|F1MMS4_BOVIN Computationally mapped isoform of Telomeric repeat-binding factor 2 OS=Bos taurus OX=9913 GN=TERF2 PE=4 SV=1 CANONICAL=F1MMS4-1" }, "locus": { "chromosome": "18", "start_pos": 36513995, "end_pos": 36492788, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125434.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125434.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085878.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085878.1" } ] } }, { "isoform_ac": "F1MMS4-1", "url": "https://www.uniprot.org/uniprotkb/F1MMS4/entry", "sequence": { "sequence": "MAAGAGTAGSASGPGVVRDPAASQSRKRPGREGGEGARRSDAMAGGGGSSDSSGRAAGRRASRSGGRARRGRHAPGLGGAAERGAGEVRLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVIESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMARKALKSESSASATVKEPQPQPAPEPVEKPLREPARQLQSTPTTIGIRTLKAAFKTLSSAQDSEAAFSKLDQKDMVFPNKVCPPSPALKNKRTRKDDNESSAPTEGEGGSELQPKTKRMTISRLVLEEDSQSTEPSSGLDSSQEVTPASPSKPTVLNQPLPGEKNPKVTKGKWNSSNGVEEKETWVEEDELFQVQAAPDEESATNTTKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN", "length": 543, "header": "tr|F1MMS4-1|F1MMS4_BOVIN Isoform 1 of Telomeric repeat-binding factor 2 OS=Bos taurus OX=9913 GN=TERF2 PE=4 SV=3 CANONICAL=F1MMS4-1" }, "locus": { "chromosome": "18", "start_pos": 36513995, "end_pos": 36492788, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010016.6", "url": "https://www.ensembl.org/id/ENSBTAT00000010016.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010016.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010016.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506501", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506501", "resource": "KEGG Pathway" }, { "id": "R-BTA-110330", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110330", "resource": "Reactome", "description": "Recognition and association of DNA glycosylase with site containing an affected purine" }, { "id": "R-BTA-110331", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-110331", "resource": "Reactome", "description": "Cleavage of the damaged purine" }, { "id": "R-BTA-171306", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-171306", "resource": "Reactome", "description": "Packaging Of Telomere Ends" }, { "id": "R-BTA-171319", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-171319", "resource": "Reactome", "description": "Telomere Extension By Telomerase" }, { "id": "R-BTA-174411", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174411", "resource": "Reactome", "description": "Polymerase switching on the C-strand of the telomere" }, { "id": "R-BTA-174414", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174414", "resource": "Reactome", "description": "Processive synthesis on the C-strand of the telomere" }, { "id": "R-BTA-174417", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174417", "resource": "Reactome", "description": "Telomere C-strand (Lagging Strand) Synthesis" }, { "id": "R-BTA-174430", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174430", "resource": "Reactome", "description": "Telomere C-strand synthesis initiation" }, { "id": "R-BTA-174437", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-174437", "resource": "Reactome", "description": "Removal of the Flap Intermediate from the C-strand" }, { "id": "R-BTA-2559586", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2559586", "resource": "Reactome", "description": "DNA Damage/Telomere Stress Induced Senescence" }, { "id": "R-BTA-9670095", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9670095", "resource": "Reactome", "description": "Inhibition of DNA recombination at telomere" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M3ART8-1", "protein_name": "Telomeric repeat binding factor a isoform X1", "gene_name": "terfa", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSDKPCEPSWEQIVNRWSFDFYAFQAFSAFRNGDYTAFTHFINIIESVVVRPVDGHPDMIPQLRLMQFLSRINNGDKLDLTFEEPKTPLESALDVLESICRDMSVPHPEQQLIRHAISEMLVMVCIRSGEFEKAEEMLKHFSSSSDSAGKKKLLLNLIRCRRSSHSVLQLSSYSHFKQDMLQFVERLFSVPEPFLLQMLRRSGWPSQRPEVRRSTQNNRRFTGKPSKRTPPHSSAAEDHGAECVSAVSRQGLQQVFDLLSEQYGVGISFFQLQDSVEVEAQQQQEGGVAGPELCLTLSETPMQTVILSDTEEQDEPRRYAGMTISRLVQEEDSQISAEHTHIEDDEEEEQTHTHRGGDWVVVLSDLESDDLDVQAGPVSSPSLRHTPKNRQNQHSSLSEPQCSSTQRSTPARLCKRSNTRVQQSESESQSSPAHCSTPARPSHPSNPRSSTRKKTPSRRRIIESSDSENEQTTPAAATHTPRGQRQQHRSIRVSSGSEPEVDSTSPAAHTRRSTPTSTHTRTTKRSKWLDASGIQDNWSDEDSLFHTSTAPAKKYTRKMWSVQESEWLKQGVVRYGVGHWERIRSSFPFAGRTAVNLKDRWRTMVKLKMV", "length": 610 }, "evidence": [ { "id": "F1MMS4", "url": "https://omabrowser.org/oma/group/F1MMS4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0XZ26-1", "protein_name": "Telomeric repeat-binding factor 2", "gene_name": "TERF2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAKRSRAAMEEQEKTSTRSDDREQAVNRWVLQFYFHQAVAAYRAGRNRDFRQLRDVMQALLVRPLEREPAVAQMLRVMQFLSRIEEGENLDCTFDKETELTPLESAIGILQLIAKEFSVPEKKIELIHKVLKEAAVIVCIKNKEFSKALAVLKRHMEKDTGNQKKRTELQTIIREKNRAHPIIRDFSYVNFQQYMFQFLKTYVDTSEPLLVTMMKSLNSEHAEEPKRSSVTPESPSRTEDQEEAYEPLRRVKHSVGTLRRAETAGGVAGAPSCPEMAKDPTGAPEHVGTVKDAVRAPCPAESTEDSQGAPRCAETARDVMGAPSPSEMTKDLLGAPKCTETARDVVRAPSPAESTKDPVGTPGHAETARDVARAPSPAETTKNLPGAPECADTVKNTVRAPSPAERRKDLVRAPKRAETARDVVRAPSPAERVKDTVGASEPMKSASYPTASQPRIAAVKSSKVFSVPVEISEQPAAAAPVHAGVSSRDLERTPFRTVTTYGISVLREAFKMLSNSPDSDALFNKLDETDLPSPQQMSPSVSHRTKRRKEEKNQGSETLDSPEIPHKSKRLFTISKMIMDQGSQCSKSSESPDSSQERVVSSAYRPVQELPDQPVSTKRSSQQRWNSSYGEERKDSWSDEDELFTDAALTETSSNNSTVYGSKKQKWTVQESEWIKDGVRKYGEGRWKTISEKYPFQNRTSVQIKDRYRTMKKLGIA", "length": 718 }, "evidence": [ { "id": "F1MMS4", "url": "https://omabrowser.org/oma/group/F1MMS4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZJF7-1", "protein_name": "Telomeric repeat-binding factor", "gene_name": "Terf2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAGAGTAGPASGPGVVRDPMASQPRKRPGGEGARRSNTMAGGGGSSDNGGRAANRRASRSGGRARRGRHEPGLGGAAERGAGEARLEEAVNRWVLKFYFHEALRAFRSSRYRDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTDSMVESSRRLVKEAAVIICIKNKEFEKASKILKKYMSKDPTTQKVRTDLLNIIREKNLAHPVIQNFSYEIFQQKMLRFLESHLDDTEPYLLTMAKKALRSESAASSTMKEEKHTEPVEKPLREPPRQPRNPPTTIGLRTVKAAFKALSTAQDSEAAFAKLDQKDLVLPNLASPSSPTHKNKRPRKDENESSAPAEGEGGSERQPRNNRMTISRLVLEEDSQSSEPSPDLNSSRQALSASPSKPRALNQPHTGEKNPKASKDKWNSPNGLEEKEVWSEEDQLFEVRAPGEDKSSNLARKQKWTIEESEWVKDGVQKYGEGNWVAISKSYPFVNRTAVMIKDRWRTMKKLGLN", "length": 536 }, "evidence": [ { "id": "F1MMS4", "url": "https://omabrowser.org/oma/group/F1MMS4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1S2L2-1", "protein_name": "Telomeric repeat-binding factor 2", "gene_name": "TERF2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAGAGTAGPASGPGVVRDPAASQSGKRPGREGGEGARRSDAMAGGGGSSDSSGRAAGRRTSRSGGRARRGRHAPRLGGAAERGAGEARLEEAVNRWVLKFYFHEALRAFRGSRYEDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESSTSSTVKEDKQPAPEPVEKPLREPARQLQNTPTTIGIMTLKAAFKTLSSAQDSEAAFSKLDQKDMVLPSKVCPPSPALKNKRPRKDENESSAPAEGEGGSELQPKNKRMTISRLVLEEDSQSTEPTAGLDSSQEGIPASPPKPTILNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVHATRDEESATNITRKQKWTVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN", "length": 542 }, "evidence": [ { "id": "F1MMS4", "url": "https://omabrowser.org/oma/group/F1MMS4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O35144-1", "protein_name": "Telomeric repeat-binding factor 2", "gene_name": "Terf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAGAGTAGPASGPGVVRDPMASQPRKRPSREGGEGGEGERRSNTMAGGGGSSDSSGRAASRRASRSGGRARRGRHEPGLGGAAERGAGEARLEEAVNRWVLKFYFHEALRAFRSSRYRDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTDSMVESSRKLVKEAAVIICIKNKEFEKASKILKKYMSKDPTTQKLRTDLLNIIREKNLAHPVIQNFSYEVFQQKMLRFLESHLDDTEPYLLTMAKKALKSESAASSTMREEKHPEPVEKPLREPPSRQPQNPPATIGIRTLKAAFKALSTAQDSEAAFAKLDQKDLVLANLASPSSPAHKHKRPRKDEHESAAPAEGEGGSDRQPRNSPMTISRLLLEEDSQSTEPSPGLNSSHKAMSASKPRALNQPHPGEKKPKASKDKWNSPNGLEEKEVWLEEDQLFEVQAPGEDRSSSLTRKQKWTIEESEWVKDGVRKYGEGNWAAISKSYPFVNRTAVMIKDRWRTMKKLGMN", "length": 541 }, "evidence": [ { "id": "F1MMS4", "url": "https://omabrowser.org/oma/group/F1MMS4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q15554-3", "protein_name": "Telomeric repeat-binding factor 2", "gene_name": "TERF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"https://www.uniprot.org/uniprotkb/F1MT56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MT56-1", "url": "https://www.uniprot.org/uniprotkb/F1MT56-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRVEPMNSTNIYDSNEDYFGLANSSDYLLDDDSFLCSLQEVRSFSGLFVPVAYSLICVCGLLGNILVVVTFAFYKKAKSMTDVYLLNMAVADILFVLTLPFWAVNHATGEWIFSNAMCKLTRGIYAINFNCGMLLLTCISLDRYIAIVQATKSFRLRSRTLAHHKLICLAVWAVSILISSSTFTFNQKYKLQGGDVCEPRYHAVSEPIRWKLLMLGLQLLFGFFIPLVFMIFCYAFIVKTLVQAQNSKRHRAIRVIIAVVLVFLACQIPHNMVLLVTAVNLGRTGRSCGSEKLLGYAKNVTEVLAFLHCCLNPALYAFIGQKFRSYFLKIMKDLWCVRKKQKAPGFSCSRLHSDTFTSRQNSETADNDNPSSFTM", "length": 375, "header": "tr|F1MT56-1|F1MT56_BOVIN Isoform 1 of C-C motif chemokine receptor 6 OS=Bos taurus OX=9913 GN=CCR6 PE=3 SV=3 CANONICAL=F1MT56-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SKS5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKS5/entry", "sequence": { "sequence": "MLFAVRVFSLVTRLNIFRLILSESSLSCSRPSCSLHCEPKEVKSPLPSSPGPAFLPRSSSRMRVEPMNSTNIYDSNEDYFGLANSSDYLLDDDSFLCSLQEVRSFSGLFVPVAYSLICVCGLLGNILVVVTFAFYKKAKSMTDVYLLNMAVADILFVLTLPFWAVNHATGEWIFSNAMCKLTRGIYAINFNCGMLLLTCISLDRYIAIVQATKSFRLRSRTLAHHKLICLAVWAVSILISSSTFTFNQKYKLQGGDVCEPRYHAVSEPIRWKLLMLGLQLLFGFFIPLVFMIFCYAFIVKTLVQAQNSKRHRAIRVIIAVVLVFLACQIPHNMVLLVTAVNLGRTGRSCGSEKLLGYAKNVTEVLAFLHCCLNPALYAFIGQKFRSYFLKIMKDLWCVRKKQKAPGFSCSRLHSDTFTSRQNSETADNDNPSSFTM", "length": 436, "header": "tr|A0AAA9SKS5-1|F1MT56_BOVIN Computationally mapped isoform of C-C motif chemokine receptor 6 OS=Bos taurus OX=9913 GN=CCR6 PE=3 SV=1 CANONICAL=F1MT56-1" }, "locus": { "chromosome": "9", "start_pos": 101925572, "end_pos": 101919134, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134893.2", "url": "https://www.ensembl.org/id/ENSBTAT00000134893.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083230.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083230.1" } ] } }, { "isoform_ac": "A0AAA9TAU3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TAU3/entry", "sequence": { "sequence": "MERGSRPSCSLHCEPKEVKSPLPSSPGPAFLPRSSSRMRVEPMNSTNIYDSNEDYFGLANSSDYLLDDDSFLCSLQEVRSFSGLFVPVAYSLICVCGLLGNILVVVTFAFYKKAKSMTDVYLLNMAVADILFVLTLPFWAVNHATGEWIFSNAMCKLTRGIYAINFNCGMLLLTCISLDRYIAIVQATKSFRLRSRTLAHHKLICLAVWAVSILISSSTFTFNQKYKLQGGDVCEPRYHAVSEPIRWKLLMLGLQLLFGFFIPLVFMIFCYAFIVKTLVQAQNSKRHRAIRVIIAVVLVFLACQIPHNMVLLVTAVNLGRTGRSCGSEKLLGYAKNVTEVLAFLHCCLNPALYAFIGQKFRSYFLKIMKDLWCVRKKQKAPGFSCSRLHSDTFTSRQNSETADNDNPSSFTM", "length": 412, "header": "tr|A0AAA9TAU3-1|F1MT56_BOVIN Computationally mapped isoform of C-C motif chemokine receptor 6 OS=Bos taurus OX=9913 GN=CCR6 PE=3 SV=1 CANONICAL=F1MT56-1" }, "locus": { "chromosome": "9", "start_pos": 101925572, "end_pos": 101924092, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000097315.2", "url": "https://www.ensembl.org/id/ENSBTAT00000097315.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093127.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093127.1" } ] } }, { "isoform_ac": "F1MT56-1", "url": "https://www.uniprot.org/uniprotkb/F1MT56/entry", "sequence": { "sequence": "MRVEPMNSTNIYDSNEDYFGLANSSDYLLDDDSFLCSLQEVRSFSGLFVPVAYSLICVCGLLGNILVVVTFAFYKKAKSMTDVYLLNMAVADILFVLTLPFWAVNHATGEWIFSNAMCKLTRGIYAINFNCGMLLLTCISLDRYIAIVQATKSFRLRSRTLAHHKLICLAVWAVSILISSSTFTFNQKYKLQGGDVCEPRYHAVSEPIRWKLLMLGLQLLFGFFIPLVFMIFCYAFIVKTLVQAQNSKRHRAIRVIIAVVLVFLACQIPHNMVLLVTAVNLGRTGRSCGSEKLLGYAKNVTEVLAFLHCCLNPALYAFIGQKFRSYFLKIMKDLWCVRKKQKAPGFSCSRLHSDTFTSRQNSETADNDNPSSFTM", "length": 375, "header": "tr|F1MT56-1|F1MT56_BOVIN Isoform 1 of C-C motif chemokine receptor 6 OS=Bos taurus OX=9913 GN=CCR6 PE=3 SV=3 CANONICAL=F1MT56-1" }, "locus": { "chromosome": "9", "start_pos": 101925572, "end_pos": 101924352, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037034.7", "url": "https://www.ensembl.org/id/ENSBTAT00000037034.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036877.5", "url": "https://www.ensembl.org/id/ENSBTAP00000036877.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1461957", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1461957", "resource": "Reactome", "description": "Beta defensins" }, { "id": "R-BTA-380108", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380108", "resource": "Reactome", "description": "Chemokine receptors bind chemokines" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A5PMT9-1", "protein_name": "C-C chemokine receptor type 6a", "gene_name": "ccr6a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MINDSSENYNYGDYYEGAVEPCSVESRQKLENFLRLFIHPIICVAGFIGNSLVIVTYALYKRTKSMTDVYLLNVAIADILFVVALPLIIYSEQHSWAMGNMSCKLLRGIYSVNLYSGMLLLACISGDRYLAIVQARRSFRLRSSTLLYSHLVCAAVWLLALLLSLPTFIFYERYENGLTESTFLFNNNTIMEEIQYVCSFKFESNETARMMKTIVPSSQVAVGFFLPLLIMGFCYSSVIVTLLRAKNFQRHKAVRVVLTVVLVFVVCHMPYNLVLLYHTINLFEQQECSHEEAVALTMTITESLAYLHSCLNPLLYAFIGVNFRNHFRKILRDIWCLGKNYMSARRSSRVTTEMYLSTRRSMDYSNNENGTSFTM", "length": 375 }, "evidence": [ { "id": "F1MT56", "url": "https://omabrowser.org/oma/group/F1MT56/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3I4D2-1", "protein_name": "C-C chemokine receptor type 6", "gene_name": "Ccr6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNSTETYFSTEDYSDSNFYSVPTDDLPCSLEEVREFTRVFVPVAYSLICVFGLLGNVMVVMTFAFYKKARSMTDVYLLNMAITDILFVLTLPFWAVTHATGTWVFSNSLCKLMKGIYAVNFNCGMLLLACISMDRYIAIVQATKSFRVRSRTLGHSKIICLVVWVISVFISSPTFIFNKKYSFQDREVCEPRYKSVSEPITWKLLGLGLELLFGFFIPLLFMVFCYLFIVKTLVQAQNSKRHRAIRVVIAVVLVFLACQIPHNVVLLITAVNTGNMNRTCRGEIRLAYARNVAEVLAFLHCCLNPVLYAFIGQKFRNYFMKIMKDVWCSRRKNKVPGFLCARMYLESYTSRQTSEIMDNDNASSFTM", "length": 367 }, "evidence": [ { "id": "F1MT56", "url": "https://omabrowser.org/oma/group/F1MT56/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LBI5-1", "protein_name": "C-C motif chemokine receptor 6", "gene_name": "CCR6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "DSGERTNELHGVYDASEDYFASVNSSDYLLDDESFLCSLQEVRKFSVLFVPLAYSLICVSGLLGNVLVVVTFAFYKKAKSMTDVYLLNMAVADILFVLTLPFWAVHHATGEWIFSNAMCKLARGIYAVNFNCGMLLLTCISLDRYIAIVQATKSFRLRSRTLAHHKAICLAVWTVSILISSSTFTFNQKYKLQGSDVCEPRYHSVAEPLRWKLLVLGLQLLFGFFIPLVFMIFCYMFIVKTLVQAQNSKRHKAIRVILAVVLVFLACQIPHNMVLLVTAVNLGRTDRSCGSERALGYARNITEVLAFLHCCLNPVLYAFIGQKFRSYFLKIMKDLWCVRRKQKAPGFSCSRLHSETFTSRQNSETPDNDNPSSFTM", "length": 376 }, "evidence": [ { "id": "F1MT56", "url": "https://omabrowser.org/oma/group/F1MT56/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O54689-1", "protein_name": "C-C chemokine receptor type 6", "gene_name": "Ccr6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSTESYFGTDDYDNTEYYSIPPDHGPCSLEEVRNFTKVFVPIAYSLICVFGLLGNIMVVMTFAFYKKARSMTDVYLLNMAITDILFVLTLPFWAVTHATNTWVFSDALCKLMKGTYAVNFNCGMLLLACISMDRYIAIVQATKSFRVRSRTLTHSKVICVAVWFISIIISSPTFIFNKKYELQDRDVCEPRYRSVSEPITWKLLGMGLELFFGFFTPLLFMVFCYLFIIKTLVQAQNSKRHRAIRVVIAVVLVFLACQIPHNMVLLVTAVNTGKVGRSCSTEKVLAYTRNVAEVLAFLHCCLNPVLYAFIGQKFRNYFMKIMKDVWCMRRKNKMPGFLCARVYSESYISRQTSETVENDNASSFTM", "length": 367 }, "evidence": [ { "id": "F1MT56", "url": "https://omabrowser.org/oma/group/F1MT56/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P51684-1", "protein_name": "C-C chemokine receptor type 6", "gene_name": "CCR6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM", "length": 374 }, "evidence": [ { "id": "F1MT56", "url": "https://omabrowser.org/oma/group/F1MT56/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5BK58-1", "protein_name": "C-C motif chemokine receptor 6", "gene_name": "Ccr6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNFTEANYGMEDYTGSDYSMFPETEPCSLQEVRDFTKVFVPIAYSLICVFGLLGNIMVVITFAFYKKARSMTDVYLLNMAITDILFVLTLPFWAVTHATDTWIFGNTMCKLMKGTYAVNFNCGMLLLACISMDRYIAIVQATKSFRVRSRTLTHSKVICLTVWFVSIIISSPTFFFNKQYKLQGRDVCEPQYKLVSEPITWKLLGMGLELLFGFFIPLLFMVFCYLFIIKTLVQAQNSKRHRAIRVVIAVVLVFLACQIPHNMVLLVTAANTGKMGRSCSAEKALAYARNVAEVLAFLHCCLNPVLYAFIGQKFRSYFMKIMKDVWCMRRKSKVPTFFCARVYSESYISRQTSETVENDNASSFTM", "length": 366 }, "evidence": [ { "id": "F1MT56", "url": "https://omabrowser.org/oma/group/F1MT56/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" }, { "name": "calcium-mediated signaling", "id": "GO:0019722", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019722", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" }, { "name": "cell chemotaxis", "id": "GO:0060326", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060326", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" }, { "name": "positive regulation of flagellated sperm motility involved in capacitation", "id": "GO:0060474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060474", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" }, { "name": "chemotaxis", "id": "GO:0006935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006935", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" }, { "name": "positive regulation of cytosolic calcium ion concentration", "id": "GO:0007204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007204", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" }, { "name": "thymocyte migration", "id": "GO:0072679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072679", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" }, { "name": "positive regulation of dendritic cell chemotaxis", "id": "GO:2000510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000510", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" }, { "name": "sperm plasma membrane", "id": "GO:0097524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097524", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "C-C chemokine receptor activity", "id": "GO:0016493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016493", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" }, { "name": "C-C chemokine binding", "id": "GO:0019957", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019957", "evidence": [ { "database": "UniProtKB", "id": "F1MT56", "url": "https://www.uniprot.org/uniprotkb/F1MT56" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } 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"count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJZ0-1", "uniprot_ac": "F1MJZ0", "uniprot_id": "F1MJZ0_BOVIN", "mass": { "chemical_mass": 42513.0, "monoisotopic_mass": 42513.0 }, "refseq": { "ac": "NP_001179906", "name": "neuropeptide S receptor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179906" }, "gene_names": [ { "name": "NPSR1", "type": "recommended", "evidence": [ { "id": "F1MJZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJZ0" } ] }, { "name": "NPSR1", "type": "synonym", "evidence": [ { "id": "NP_001179906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179906" } ] } ], "protein_names": [ { "name": "Neuropeptide S receptor", "type": "recommended", "evidence": [ { "id": "F1MJZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJZ0/entry#names_and_taxonomy" } ] }, { "name": "G-protein coupled receptor 154", "type": "synonym", "evidence": [ { "id": "F1MJZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJZ0/entry#names_and_taxonomy" } ] }, { "name": "neuropeptide S receptor", "type": "synonym", "evidence": [ { "id": "NP_001179906", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179906" } ] } ], "function": [ { "annotation": "G-protein coupled receptor for neuropeptide S (NPS). Receptor activation by NPS initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway, resulting in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels. In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction. Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade. Inhibits cell growth in response to NPS binding.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SPZ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ3#function" }, { "database": "UniProtKB", "id": "ARBA00094235", "url": "https://www.uniprot.org/uniprotkb/ARBA00094235#function" }, { "database": "UniProtKB", "id": "F1MJZ0", "url": "https://www.uniprot.org/uniprotkb/F1MJZ0#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJZ0", "url": "https://www.uniprot.org/uniprotkb/F1MJZ0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NPSR1", "url": "https://www.uniprot.org/uniprotkb/F1MJZ0", "locus": { "chromosome": "4", "start_pos": 62120709, "end_pos": 62274639, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013768", "url": "https://www.ensembl.org/id/ENSBTAG00000013768" } ] } } ], "crossref": [ { "id": "F1MJZ0", "url": "https://alphafold.ebi.ac.uk/entry/F1MJZ0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013768", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013768", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15197", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15197", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519486", "url": "https://www.ncbi.nlm.nih.gov/gene/519486", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001817", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001817", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027294", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519486", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519486", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NRLCPPF", "url": "https://omabrowser.org/oma/group/NRLCPPF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MJZ0", "url": "https://www.orthodb.org/?gene=F1MJZ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24244", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24244", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24244:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24244:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00001", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-375276", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-416476", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179906", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SPZ3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV44", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TV44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV44-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYY0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYY0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJZ0", "url": "https://www.uniprot.org/uniprotkb/F1MJZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJZ0-1", "url": "https://www.uniprot.org/uniprotkb/F1MJZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPANLTEGSAKSNGTGQALNSPVLCTETVTFTAEVEGEEWGSFYYSFKTEQLITLWVLFVFTIVGNAIVLFSTWRRKRKSRMTFFVTQLAITDSFTGLVNILTDIIWRFTGDFMAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQAKVLIMIAWSLSFLFSIPTLIIFGKRKLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISVIYAIVIRTIWVKSKAYETVISNCSDGKLCTSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDILDNFSLLPNTKERFYASVIIQNLPALNSAINPLIYCVFSNSICFPCREQRSRDSRMTCRERTEKHEMQVLSKPEFM", "length": 370, "header": "tr|F1MJZ0-1|F1MJZ0_BOVIN Isoform 1 of Neuropeptide S receptor OS=Bos taurus OX=9913 GN=NPSR1 PE=3 SV=2 CANONICAL=F1MJZ0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPZ3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPZ3/entry", "sequence": { "sequence": "MPANLTEGSAKSNGTGQALNSPVLCTETVTFTAEVEGEEWGSFYYSFKTEQLITLWVLFVFTIVGNAIVLFSTWRRKRKSRMTFFVTQLAITDSFTGLVNILTDIIWRFTGDFMAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQAKVLIMIAWSLSFLFSIPTLIIFGKRKLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISVIYAIVIRTIWVKSKAYETVISNCSDGKLCTSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDILDNFSLLPNTKERFYASVIIQNLPALNSAINPLIYCVFSNSICFPCRGNSNSSAYILASDVSVWALVLICRKEGCEWWGSMGAKITGFQNDMSGEN", "length": 390, "header": "tr|A0AAA9SPZ3-1|F1MJZ0_BOVIN Computationally mapped isoform of Neuropeptide S receptor OS=Bos taurus OX=9913 GN=NPSR1 PE=3 SV=1 CANONICAL=F1MJZ0-1" }, "locus": { "chromosome": "4", "start_pos": 62274639, "end_pos": 62121087, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096515.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096515.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087441.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087441.1" } ] } }, { "isoform_ac": "A0AAA9TV44-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TV44/entry", "sequence": { "sequence": "MPANLTEGSAKSNGTGQALNSPVLCTETVTFTAEVEGEEWGSFYYSFKTEQLITLWVLFVFTIVGNAIVLFSTWRRKRKSRMTFFVTQLAITV", "length": 93, "header": "tr|A0AAA9TV44-1|F1MJZ0_BOVIN Computationally mapped isoform of Neuropeptide S receptor OS=Bos taurus OX=9913 GN=NPSR1 PE=3 SV=1 CANONICAL=F1MJZ0-1" }, "locus": { "chromosome": "4", "start_pos": 62274639, "end_pos": 62244121, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134464.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134464.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100997.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100997.1" } ] } }, { "isoform_ac": "A0AAA9TYY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYY0/entry", "sequence": { "sequence": "MPANLTEGSAKSNGTGQALNSPVLCTETVTFTAEVEGEEWGSFYYSFKTEQLITLWVLFVFTIVGNAIVLFSTWRRKRKSRMTFFVTQLAITEKQAKVLIMIAWSLSFLFSIPTLIIFGKRKLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISVIYAIVIRTIWVKSKAYETVISNCSDGKLCTSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDILDNFSLLPNTKERFYASVIIQNLPALNSAINPLIYCVFSNSICFPCREQRSRDSRMTCRERTEKHEMQVLSKPEFM", "length": 304, "header": "tr|A0AAA9TYY0-1|F1MJZ0_BOVIN Computationally mapped isoform of Neuropeptide S receptor OS=Bos taurus OX=9913 GN=NPSR1 PE=3 SV=1 CANONICAL=F1MJZ0-1" }, "locus": { "chromosome": "4", "start_pos": 62274639, "end_pos": 62121044, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000125738.1", "url": "https://www.ensembl.org/id/ENSBTAT00000125738.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102721.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102721.1" } ] } }, { "isoform_ac": "F1MJZ0-1", "url": "https://www.uniprot.org/uniprotkb/F1MJZ0/entry", "sequence": { "sequence": "MPANLTEGSAKSNGTGQALNSPVLCTETVTFTAEVEGEEWGSFYYSFKTEQLITLWVLFVFTIVGNAIVLFSTWRRKRKSRMTFFVTQLAITDSFTGLVNILTDIIWRFTGDFMAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQAKVLIMIAWSLSFLFSIPTLIIFGKRKLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISVIYAIVIRTIWVKSKAYETVISNCSDGKLCTSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDILDNFSLLPNTKERFYASVIIQNLPALNSAINPLIYCVFSNSICFPCREQRSRDSRMTCRERTEKHEMQVLSKPEFM", "length": 370, "header": "tr|F1MJZ0-1|F1MJZ0_BOVIN Isoform 1 of Neuropeptide S receptor OS=Bos taurus OX=9913 GN=NPSR1 PE=3 SV=2 CANONICAL=F1MJZ0-1" }, "locus": { "chromosome": "4", "start_pos": 62274639, "end_pos": 62121044, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018290.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018290.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018290.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018290.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519486", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519486", "resource": "KEGG Pathway" }, { "id": "R-BTA-375276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "resource": "Reactome", "description": "Peptide ligand-binding receptors" }, { "id": "R-BTA-416476", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416476", "resource": "Reactome", "description": "G alpha (q) signalling events" }, { "id": "R-BTA-418555", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418555", "resource": "Reactome", "description": "G alpha (s) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MR91-1", "protein_name": "Neuropeptide S receptor", "gene_name": "Npsr1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPANLTEGNSHVNQTVPTLDASPVACTEIVTFTEVLATEEWGSFYSSFKTEQLITLWVLFIFTIVGNSVVLFSTWRRKRKSRMTFFVTQLAITDSFTGLINILTDIIWRFTGDFMAPDLVCRVVRYLQVVVLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQAKVLIGIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISVIYGLVIRTIWIKSKAHETVISNCSDGKLCSRYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDMLDNFNLLPDTKERFYASVIIQNLPALNSAINPVIYCIFSSSICFPCKEQRSQDSRMTYRERSERQEMQILSKPEFI", "length": 371 }, "evidence": [ { "id": "F1MJZ0", "url": "https://omabrowser.org/oma/group/F1MJZ0/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P0C0L6-1", "protein_name": "Neuropeptide S receptor", "gene_name": "Npsr1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPANLTEGSFHANQTVPMLDSSPVACTEIVTFTEALEAEEWGSFYSSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKRKSRMTFFVTQLAITDSFTGLINILTDIIWRFTGDFMAPDLVCRIVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGAEKQAKVLIGIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISVIYGLVIRTIWIKSKAHETVISNCSDGELCCSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDMLDNFNLLPDTKERFYASVIIQNLPALNSAINPLIYCIFSGSLCSPCKVQRSQDSRMTYRERSERHEMQILSKPEFI", "length": 372 }, "evidence": [ { "id": "F1MJZ0", "url": "https://omabrowser.org/oma/group/F1MJZ0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6W5P4-1", "protein_name": "Neuropeptide S receptor", "gene_name": "NPSR1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI", "length": 371 }, "evidence": [ { "id": "F1MJZ0", "url": "https://omabrowser.org/oma/group/F1MJZ0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BZP8-1", "protein_name": "Neuropeptide S receptor", "gene_name": "Npsr1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPANLTEGSFHANQTVPMLDSSPVACTEIVTFTEALVAEEWGSFYSSFKTEQLITLWVLFVVTIVGNSVVLFSTCRRKRKSRMTFFVTQLAITDSFTGLINILTDIIWRFTGDFMAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQAKVLIGIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLAIISVIYGLVIRTIWMKSKTHETVISNCSDGKLCCSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDILDNFNVLPDTKERFYASVIIQNLPALNSAINPLIYCIFSSSICSPCKMQRSQDSRMTYRERSERHEMQILSKPEFI", "length": 371 }, "evidence": [ { "id": "F1MJZ0", "url": "https://omabrowser.org/oma/group/F1MJZ0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MJZ0", "url": "https://www.uniprot.org/uniprotkb/F1MJZ0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": 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"NP_001192329", "name": "rRNA 2'-O-methyltransferase fibrillarin", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192329" }, "gene_names": [ { "name": "FBL", "type": "recommended", "evidence": [ { "id": "F1MM59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM59" } ] }, { "name": "FBL", "type": "synonym", "evidence": [ { "id": "NP_001192329", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192329" } ] } ], "protein_names": [ { "name": "Fibrillarin", "type": "synonym", "evidence": [ { "id": "F1MM59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM59/entry#names_and_taxonomy" } ] }, { "name": "rRNA 2'-O-methyltransferase fibrillarin", "type": "synonym", "evidence": [ { "id": "NP_001192329", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192329" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MM59", "url": "https://www.uniprot.org/uniprotkb/F1MM59" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FBL", "url": "https://www.uniprot.org/uniprotkb/F1MM59", "locus": { "chromosome": "18", "start_pos": 49388469, "end_pos": 49400795, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002579", "url": "https://www.ensembl.org/id/ENSBTAG00000002579" } ] } } ], "crossref": [ { "id": "F1MM59", "url": "https://alphafold.ebi.ac.uk/entry/F1MM59", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002579", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002579", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "538548", "url": "https://www.ncbi.nlm.nih.gov/gene/538548", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000692", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000692", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020813", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020813", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:538548", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538548", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WNPNKSK", "url": "https://omabrowser.org/oma/group/WNPNKSK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MM59", "url": "https://www.orthodb.org/?gene=F1MM59", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10335", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10335", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10335:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10335:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01269", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01269", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6791226", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001192329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192329", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T222", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T222", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T222-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T222-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0J1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0J1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0J1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0J1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM59", "url": "https://www.uniprot.org/uniprotkb/F1MM59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM59-1", "url": "https://www.uniprot.org/uniprotkb/F1MM59-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPGFSPRGGGFGGRGGFGDRGGRGGGRGGFGGGRGGFGGGRGRGGGGGGFRGRGRGGGGRGGGFQSGGNRGRGRGGKKGNPSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN", "length": 322, "header": "tr|F1MM59-1|F1MM59_BOVIN Isoform 1 of Fibrillarin OS=Bos taurus OX=9913 GN=FBL PE=3 SV=2 CANONICAL=F1MM59-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T222-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T222/entry", "sequence": { "sequence": "MKPGFSPRGGGFGGRGGFGDRGGRGGGRGGFGGGRGRGGGGGGFRGRGRGGGGRGGGFQSGGNRGRGRGGKKGNPSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN", "length": 315, "header": "tr|A0AAA9T222-1|F1MM59_BOVIN Computationally mapped isoform of Fibrillarin OS=Bos taurus OX=9913 GN=FBL PE=3 SV=1 CANONICAL=F1MM59-1" }, "locus": { "chromosome": "18", "start_pos": 49400693, "end_pos": 49388550, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114462.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114462.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091777.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091777.1" } ] } }, { "isoform_ac": "A0AAA9U0J1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0J1/entry", "sequence": { "sequence": "MATHSSILGFSPRGGGFGGRGGFGDRGGRGGGRGGFGGGRGGFGGGRGRGGGGGGFRGRGRGGGGRGGGFQSGGNRGRGRGGKKGNPSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN", "length": 327, "header": "tr|A0AAA9U0J1-1|F1MM59_BOVIN Computationally mapped isoform of Fibrillarin OS=Bos taurus OX=9913 GN=FBL PE=3 SV=1 CANONICAL=F1MM59-1" }, "locus": { "chromosome": "18", "start_pos": 49398996, "end_pos": 49388550, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000096009.1", "url": "https://www.ensembl.org/id/ENSBTAT00000096009.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103135.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103135.1" } ] } }, { "isoform_ac": "F1MM59-1", "url": "https://www.uniprot.org/uniprotkb/F1MM59/entry", "sequence": { "sequence": "MKPGFSPRGGGFGGRGGFGDRGGRGGGRGGFGGGRGGFGGGRGRGGGGGGFRGRGRGGGGRGGGFQSGGNRGRGRGGKKGNPSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN", "length": 322, "header": "tr|F1MM59-1|F1MM59_BOVIN Isoform 1 of Fibrillarin OS=Bos taurus OX=9913 GN=FBL PE=3 SV=2 CANONICAL=F1MM59-1" }, "locus": { "chromosome": "18", "start_pos": 49400693, "end_pos": 49388550, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003340.6", "url": "https://www.ensembl.org/id/ENSBTAT00000003340.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003340.5", "url": "https://www.ensembl.org/id/ENSBTAP00000003340.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:538548", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:538548", "resource": "KEGG Pathway" }, { "id": "R-BTA-6791226", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6791226", "resource": "Reactome", "description": "Major pathway of rRNA processing in the nucleolus and cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "P22087-1", "protein_name": "rRNA 2'-O-methyltransferase fibrillarin", "gene_name": "FBL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKPGFSPRGGGFGGRGGFGDRGGRGGRGGFGGGRGRGGGFRGRGRGGGGGGGGGGGGGRGGGGFHSGGNRGRGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN", "length": 321 }, "evidence": [ { "id": "F1MM59", "url": "https://omabrowser.org/oma/group/F1MM59/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P22509-1", "protein_name": "rRNA 2'-O-methyltransferase fibrillarin", "gene_name": "Fbl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKPGFSPRGGGFGGRGGFGDRGGRGGGRGGRGGFGGGRGGFGGGGRGRGGGGGGFRGRGGGGGRGGGFQSGGGRGRGGGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKAKN", "length": 327 }, "evidence": [ { "id": "F1MM59", "url": "https://omabrowser.org/oma/group/F1MM59/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P35550-1", "protein_name": "rRNA 2'-O-methyltransferase fibrillarin", "gene_name": "Fbl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKPGFSPRGGGFGGRGGFGDRGGRGGGRGGRGGFGGGRGGFGGGGRGRGGGGGGFRGRGGGGGRGGGFQSGGNRGRGGGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN", "length": 327 }, "evidence": [ { "id": "F1MM59", "url": "https://omabrowser.org/oma/group/F1MM59/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q55CW0-1", "protein_name": "rRNA 2'-O-methyltransferase fibrillarin", "gene_name": "fbl", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MEGRGGSRGGAMARGGGRGGFGGGRGGFGGGDRGGRGGGRGGFGGGDRGGRGGFGGGRGGRGGFGGGDRGGRGGARGGRGGARGGKPAAGGKPGAKVIVEKHPRHEGVFIVRGKEESLATLNSVPGESVYGEKRVSVGEGEDKKEYRIWNPFRSKIAAGLHRGVDEIHIKPGSKVLYIGAASGTTISHVSDIVGPTGVVYGIELSHRPGRDLIGMAKKRTNVIPIIEDARHPQKYRMLIGMVDVVFADVAQPNQAQIVAQNSAYFLKNEGHFIISIKASCIDSTAPTEVVVQNEITKLKKEKLRPQHLLKTLDPYERNHSLVIGVYRKFGSSEK", "length": 334 }, "evidence": [ { "id": "F1MM59", "url": "https://omabrowser.org/oma/group/F1MM59/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q94AH9-1", "protein_name": "rRNA 2'-O-methyltransferase fibrillarin 2", "gene_name": "FIB2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MRPPLTGSGGGFSGGRGRGGYSGGRGDGGFSGGRGGGGRGGGRGFSDRGGRGRGRGPPRGGARGGRGPAGRGGMKGGSKVIVEPHRHAGVFIAKGKEDALVTKNLVPGEAVYNEKRISVQNEDGTKTEYRVWNPFRSKLAAAILGGVDNIWIKPGAKVLYLGAASGTTVSHVSDLVGPEGCVYAVEFSHRSGRDLVNMAKKRTNVIPIIEDARHPAKYRMLVGMVDVIFSDVAQPDQARILALNASYFLKSGGHFVISIKANCIDSTVPAEAVFQTEVKKLQQEQFKPAEQVTLEPFERDHACVVGGYRMPKKPKAATAA", "length": 320 }, "evidence": [ { "id": "F1MM59", "url": "https://omabrowser.org/oma/group/F1MM59/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9W1V3-1", "protein_name": "rRNA 2'-O-methyltransferase fibrillarin", "gene_name": "Fib", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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{ "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" }, { "id": "R-BTA-9648025", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9648025", "resource": "Reactome", "description": "EML4 and NUDC in mitotic spindle formation" } ], "orthologs": [ { "uniprot_canonical_ac": "F1RH86-1", "protein_name": "B9 domain-containing protein 2", "gene_name": "B9D2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAEVHVIGQIMGATGFSESSLFCKWGVHTGAAWKLLSGVREGQTQVDTPQIGDMAYWSHPIDLHFATKGLQGWPRLHLQVWSQDSFGRCQLAGYGFCHVPSSPGTHQLDCPTWRPLGSWREQLARAFVGGGPQLLHGDAIYSGADRYRLHTAAGGTVHLELGLLLRHFDRYGVEC", "length": 175 }, "evidence": [ { "id": "F1MT24", "url": "https://omabrowser.org/oma/group/F1MT24/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "M9MRD5-1", "protein_name": "B9 domain-containing protein 2", "gene_name": "B9d2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAEVHIIGQILKAVDFAEPHLYCKWSLQSGNAWRLVQGEVQGQSHVASHRLQSSSDFAQPLDIHLSTASVQGWPRLLVEVYAVNVLQQSWPVGYGFVHVPSTPGTHRLEIGTWKVAPNGLWQSLRERFGGGGAALSKTDLLYSGVERYKLQTLSSGKVIVELNLIFRKFDEYGVEFK", "length": 177 }, "evidence": [ { "id": "F1MT24", "url": "https://omabrowser.org/oma/group/F1MT24/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P0C5J3-1", "protein_name": "B9 domain-containing protein 2", "gene_name": "B9d2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEVHVIGQIIGATGFSEGSLFCKWGIHTGAAWKLLSGVREGQTQVDTPQTGDMAYWSHPIDLHFATKGLQGWPRLHLQVWSQDSFGRCQLAGYGFCHVPSSPGTHQLDCPTWRPLGSWREQLARAFVGGGPQLLHADTIYSGADRYRLHTAAGGTVHLGIGLLLRHFDRYGVEC", "length": 175 }, "evidence": [ { "id": "F1MT24", "url": "https://omabrowser.org/oma/group/F1MT24/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3UK10-1", "protein_name": "B9 domain-containing protein 2", "gene_name": "B9d2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEVHVIGQIIGATGFSESSLFCKWGIHTGAAWKLLSGVREGQTQVDTPQIGDMAYWSHPIDLHFATKGLQGWPRLHLQVWSQDSFGRCQLAGYGFCHVPSSPGTHQLDCPTWRPLGSWREQLARAFVGGGPQLLHADTIYSGADRYRLHTAAGGTVHLGIGLLLRHFDRYGVEC", "length": 175 }, "evidence": [ { "id": "F1MT24", "url": "https://omabrowser.org/oma/group/F1MT24/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6DGZ1-1", "protein_name": "B9 domain-containing protein 2", "gene_name": "b9d2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAELHIIGQIIGATGFPQNSLFCKWGVHTGGAWRLLSGLREGQTQVDMPQTGDMAYWSHPIDLHYTTKGLQGWPKLHLQVWHQDSFGRCQLYGYGYIHVPSSPGQHRLQCVTWRPLGSWQDQLSEMFVGGGPQLRSPDLIYSGADRYRLHTVGMGTVELELCIILRHFDRYGVES", "length": 175 }, "evidence": [ { "id": "F1MT24", "url": "https://omabrowser.org/oma/group/F1MT24/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9BPU9-1", "protein_name": "B9 domain-containing protein 2", "gene_name": "B9D2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEVHVIGQIIGASGFSESSLFCKWGIHTGAAWKLLSGVREGQTQVDTPQIGDMAYWSHPIDLHFATKGLQGWPRLHFQVWSQDSFGRCQLAGYGFCHVPSSPGTHQLACPTWRPLGSWREQLARAFVGGGPQLLHGDTIYSGADRYRLHTAAGGTVHLEIGLLLRNFDRYGVEC", "length": 175 }, "evidence": [ { "id": "F1MT24", "url": "https://omabrowser.org/oma/group/F1MT24/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "F1MT24", "url": "https://www.uniprot.org/uniprotkb/F1MT24" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1MT24", "url": "https://www.uniprot.org/uniprotkb/F1MT24" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MT24", "url": "https://www.uniprot.org/uniprotkb/F1MT24" } ], "pmid": "" }, { "name": "MKS complex", "id": "GO:0036038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036038", "evidence": [ { "database": "UniProtKB", "id": "F1MT24", "url": "https://www.uniprot.org/uniprotkb/F1MT24" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "F1MT24", "url": "https://www.uniprot.org/uniprotkb/F1MT24" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell projection organization", "id": "GO:0030030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030030", "evidence": [ { "database": "UniProtKB", "id": "F1MT24", "url": "https://www.uniprot.org/uniprotkb/F1MT24" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "F1MT24", "url": "https://www.uniprot.org/uniprotkb/F1MT24" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "gamma-tubulin binding", "id": "GO:0043015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043015", "evidence": [ { "database": "UniProtKB", "id": "F1MT24", "url": "https://www.uniprot.org/uniprotkb/F1MT24" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MS44-1", "uniprot_ac": "F1MS44", "uniprot_id": "F1MS44_BOVIN", "mass": { "chemical_mass": 52956.0, "monoisotopic_mass": 52956.0 }, "refseq": { "ac": "XP_059736633", "name": "doublecortin domain-containing protein 2 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059736633" }, "gene_names": [ { "name": "DCDC2", "type": "recommended", "evidence": [ { "id": "F1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ] }, { "name": "DCDC2", "type": "synonym", "evidence": [ { "id": "XP_059736633", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059736633" } ] } ], "protein_names": [ { "name": "Doublecortin domain-containing protein 2", "type": "recommended", "evidence": [ { "id": "F1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS44/entry#names_and_taxonomy" } ] }, { "name": "doublecortin domain-containing protein 2 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_059736633", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059736633" } ] } ], "function": [ { "annotation": "Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex. Involved in the control of ciliogenesis and ciliary length.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TH25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH25#function" }, { "database": "UniProtKB", "id": "ARBA00057353", "url": "https://www.uniprot.org/uniprotkb/ARBA00057353#function" }, { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DCDC2", "url": "https://www.uniprot.org/uniprotkb/F1MS44", "locus": { "chromosome": "23", "start_pos": 33480706, "end_pos": 33334549, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009798", "url": "https://www.ensembl.org/id/ENSBTAG00000009798" } ] } } ], "crossref": [ { "id": "F1MS44", "url": "https://alphafold.ebi.ac.uk/entry/F1MS44", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009798", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009798", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17152", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17152", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100297854", "url": "https://www.ncbi.nlm.nih.gov/gene/100297854", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003533", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003533", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033036", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033036", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036572", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036572", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100297854", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100297854", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MHSRINV", "url": "https://omabrowser.org/oma/group/MHSRINV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MS44", "url": "https://www.orthodb.org/?gene=F1MS44", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23004", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23004", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23004:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23004:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03607", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03607", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059736633", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059736633", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TH25", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TH25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH25-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS44-1", "url": "https://www.uniprot.org/uniprotkb/F1MS44-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRTSARSGHLSQPVVKSVLVYRNGDPFFTGRRVVFHEKKVSSFDVFLKEVTGGVQAPFGAVRNIYTPRTGHRIWRLDQIQSGGNYVAGGQESFKKLNYLDIGEIKKRPMEAVRTEVKPVTHSRINVSSRFRKPLLEPCTIFLIANGDLINPASRLLIPRKALNQWDHVLQMITEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDRFKKLPYSELLFDKSTMRKSYGQKTSSLPPIVGSRKSKGSGNDRQSKSTVGSSDNSSPQPPKRKGKKHANSEKPTKGKQNAKLKSSPQTIPNSDEGVFKAGEERSETRGAAEVQEDEDTQVEIPVDQRPAEIVDEEEDREKENKEVEQKDDFSGMNGEVKEEEGDQEEPEAAEQAEEIPDHREEQAGSAARVNGGTDEENGEELAQVNNELQEAVEEEIKSQGAGSEHEEADLDPQRPPKPEVKITSPQENDDNEQNKDNLS", "length": 475, "header": "tr|F1MS44-1|F1MS44_BOVIN Isoform 1 of Doublecortin domain-containing protein 2 OS=Bos taurus OX=9913 GN=DCDC2 PE=4 SV=3 CANONICAL=F1MS44-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TH25-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TH25/entry", "sequence": { "sequence": "MSRTSARSGHLSQPVVKSVLVYRNGDPFFTGRRVVFHEKKVSSFDVFLKEVTGGVQAPFGAVRNIYTPRTGHRIWRLDQIQSGGNYVAGGQESFKKLNYLDIGEIKKRPMEAVRTEDFTDKFYHPRMVPACNNDYSAVYLMVKPVTHSRINVSSRFRKPLLEPCTIFLIANGDLINPASRLLIPRKALNQWDHVLQMITEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDRFKKLPYSELLFDKSTMRKSYGQKTSSLPPIVGSRKSKGSGNDRQSKSTVGSSDNSSPQPPKRKGKKHANSEKPTKGKQNAKLKSSPQTIPNSDEGVFKAGEERSETRGAAEVQEDEDTQVEIPVDQRPAEIVDEEEDREKENKEVEQKDDFSGMNGEVKEEEGDQEEPEAAEQAEEIPDHREEQAGSAARVNGGTDEENGEELAQVNNELQEAVEEEIKSQGAGSEHEEADLDPQRPPKPEVKITSPQENDDNEQNKDNLS", "length": 500, "header": "tr|A0AAA9TH25-1|F1MS44_BOVIN Computationally mapped isoform of Doublecortin domain-containing protein 2 OS=Bos taurus OX=9913 GN=DCDC2 PE=4 SV=1 CANONICAL=F1MS44-1" }, "locus": { "chromosome": "23", "start_pos": 33479702, "end_pos": 33335556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127635.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127635.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097834.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097834.1" } ] } }, { "isoform_ac": "F1MS44-1", "url": "https://www.uniprot.org/uniprotkb/F1MS44/entry", "sequence": { "sequence": "MSRTSARSGHLSQPVVKSVLVYRNGDPFFTGRRVVFHEKKVSSFDVFLKEVTGGVQAPFGAVRNIYTPRTGHRIWRLDQIQSGGNYVAGGQESFKKLNYLDIGEIKKRPMEAVRTEVKPVTHSRINVSSRFRKPLLEPCTIFLIANGDLINPASRLLIPRKALNQWDHVLQMITEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDRFKKLPYSELLFDKSTMRKSYGQKTSSLPPIVGSRKSKGSGNDRQSKSTVGSSDNSSPQPPKRKGKKHANSEKPTKGKQNAKLKSSPQTIPNSDEGVFKAGEERSETRGAAEVQEDEDTQVEIPVDQRPAEIVDEEEDREKENKEVEQKDDFSGMNGEVKEEEGDQEEPEAAEQAEEIPDHREEQAGSAARVNGGTDEENGEELAQVNNELQEAVEEEIKSQGAGSEHEEADLDPQRPPKPEVKITSPQENDDNEQNKDNLS", "length": 475, "header": "tr|F1MS44-1|F1MS44_BOVIN Isoform 1 of Doublecortin domain-containing protein 2 OS=Bos taurus OX=9913 GN=DCDC2 PE=4 SV=3 CANONICAL=F1MS44-1" }, "locus": { "chromosome": "23", "start_pos": 33479702, "end_pos": 33335556, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012923.8", "url": "https://www.ensembl.org/id/ENSBTAT00000012923.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012923.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012923.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100297854", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100297854", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y067-1", "protein_name": "Doublecortin domain-containing protein 2", "gene_name": "DCDC2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTNPGTKGSFLSQPMVKSVLVYRNGDPFFPGRRIVINEKKVSNFEVFLKEVTGGVKAPFGAVRNIYTPRAGHRVRQLEELQSGEQYVAGGREAFKKLNYLDIGETKKKPAEANNEVKPVTHSRITASARFRKPLQEPYTIFLIANGDLISPVVRLLIPRKTLNHWDHILEMVTAKVSLRSGAVHRLYTLDGKHVQNGSDLEKGQFYVAVGREKFKKLPYGELLFSKSTIRPQGSKASVLPPIAGSRKSKGSGNDRQSKSTVASSDPGEKSSSPQPPKEKVKKCHNPEDSTSRGYSSNKSAKVKQTASTGFLQDNGEGIYRASEKRPEMWGAAEVQEDEDTRVEVPLDQRPAETVDEEENAEEENDREEEEAYKQKEEYPEVNGEESGETVTKSNREGENKNKLNGNYEHETENVDQAEEEDLIHLNGKINEENGEGMEQMNSQEDLQHEEDVKEDYSGSQNQIYSIFHVVTDIFVLFLEKLKSFMALEKVDSHHEKPSRNPRVTITSPQESEKKDQSNDYAVVA", "length": 524 }, "evidence": [ { "id": "F1MS44", "url": "https://omabrowser.org/oma/group/F1MS44/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZR10-1", "protein_name": "Doublecortin domain-containing protein 2", "gene_name": "Dcdc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNGPSPRSSHLSQPVVKSVLVYRNGDPFFAGRRVVIHEKKVSSFDIFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIESGGNYVAGGQEAFKKLNYLDIGEIKKRPMEAVNTEVKPVIHSKINVSARFRKALHEPCTIFLIANGDLISPASRLLIPRKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKRLPYSELLFDKSAMRRPYGQKASSLPPMVGSRKSKGSGNYRQSKSTIGSSDNSSPQPLKRKGKKDSNSEKPTKVKQSVKSKNSHQAIPDNDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKTSKDANQKDDFSAMNGEAEDRAGSKVADAPEEEEGIPDQGEKKASPSRVNGGTDEENGEELDQVTEELQPTVDEKGKAEGDNSAQDEAGLDAQRPPRPEVTVTSPQENEGNESNKASSAVA", "length": 475 }, "evidence": [ { "id": "F1MS44", "url": "https://omabrowser.org/oma/group/F1MS44/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5DU00-1", "protein_name": "Doublecortin domain-containing protein 2", "gene_name": "Dcdc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNGPSSRSSHLSQPVVKSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIESGGNYVAGGPEAFKKLNYLDIGEIKKRPMEAVNTEVKPVIHSRINVSARFRKSLHEPCTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKRLPYSELLFDKSAMRRPYGQKASSLPPMVGSRKSKGSGNYRQSKSTIGSSDNSSPQPLKRKGKKDSNSEKPTKVKQSVKSKTSHQAIPDNGEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKTSKDANQKEDFSAMNGETEDRGGSKAAGTSEQEEGIPDHGEKKSSPSRVNGGTDEENGEELDQVAEELQPTEDEKGKAEGDNSGQDEAGLDAQRPPRPEVTVTSPQENEENEANKASSAVA", "length": 475 }, "evidence": [ { "id": "F1MS44", "url": "https://omabrowser.org/oma/group/F1MS44/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UHG0-1", "protein_name": "Doublecortin domain-containing protein 2", "gene_name": "DCDC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGSSARSSHLSQPVVKSVLVYRNGDPFYAGRRVVIHEKKVSSFEVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIQSGGNYVAGGQEAFKKLNYLDIGEIKKRPMEVVNTEVKPVIHSRINVSARFRKPLQEPCTIFLIANGDLINPASRLLIPRKTLNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKKLPYSELLFDKSTMRRPFGQKASSLPPIVGSRKSKGSGNDRHSKSTVGSSDNSSPQPLKRKGKKEDVNSEKLTKLKQNVKLKNSQETIPNSDEGIFKAGAERSETRGAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEKANKDAEQKEDFSGMNGDLEEEGGREATDAPEQVEEILDHSEQQARPARVNGGTDEENGEELQQVNNELQLVLDKERKSQGAGSGQDEADVDPQRPPRPEVKITSPEENENNQQNKDYAAVA", "length": 476 }, "evidence": [ { "id": "F1MS44", "url": "https://omabrowser.org/oma/group/F1MS44/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "positive regulation of smoothened signaling pathway", "id": "GO:0045880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045880", "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "pmid": "" }, { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "pmid": "" }, { "name": "regulation of Wnt signaling pathway", "id": "GO:0030111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030111", "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "pmid": "" }, { "name": "regulation of cilium assembly", "id": "GO:1902017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902017", "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "pmid": "" }, { "name": "neuron migration", "id": "GO:0001764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "pmid": "" }, { "name": "dendrite morphogenesis", "id": "GO:0048813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048813", "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "axoneme", "id": "GO:0005930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "pmid": "" }, { "name": "kinocilium", "id": "GO:0060091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060091", "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "pmid": "" }, { "name": "mitotic spindle", "id": "GO:0072686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "pmid": "" }, { "name": "microtubule organizing center", "id": "GO:0005815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "evidence": [ { "database": "UniProtKB", "id": "F1MS44", "url": "https://www.uniprot.org/uniprotkb/F1MS44" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 268, "end_pos": 270, "annotation": "n_glycosylation_sequon" }, { "start_pos": 473, "end_pos": 475, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MS44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS44" }, { "id": "PS50309", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50309" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Doublecortin", "eco_id": "ECO_0000259", "start_pos": 17, "end_pos": 100, "start_aa": "Lys", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 126, "end_pos": 128 }, { "start_pos": 268, "end_pos": 270 }, { "start_pos": 473, "end_pos": 475 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MT58-1", "uniprot_ac": "F1MT58", "uniprot_id": "F1MT58_BOVIN", "mass": { "chemical_mass": 37148.0, "monoisotopic_mass": 37148.0 }, "refseq": {}, "gene_names": [ { "name": "20ALPHA-HSD", "type": "recommended", "evidence": [ { "id": "F1MT58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT58" } ] } ], "protein_names": [ { "name": "Placental and ovary 20alpha hydroxysteroid dehydrogenase protein", "type": "synonym", "evidence": [ { "id": "F1MT58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT58/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MT58", "url": "https://www.uniprot.org/uniprotkb/F1MT58" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "20ALPHA-HSD", "url": "https://www.uniprot.org/uniprotkb/F1MT58", "locus": {} } ], "crossref": [ { "id": "F1MT58", "url": "https://alphafold.ebi.ac.uk/entry/F1MT58", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039356", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039356", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000039643", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039643", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19108", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19108", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR018170", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018170", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020471", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020471", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036812", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036812", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044482", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044482", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WCKDATL", "url": "https://omabrowser.org/oma/group/WCKDATL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "M0QW14", "url": "https://www.orthodb.org/?gene=M0QW14", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11732", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00248", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00248", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-193368", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-193368", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-193775", "url": 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"https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8876198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LYZ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYZ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LYZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYZ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7F1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7F1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M7F1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7F1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBX6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBX6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBX6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBX6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5L5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S5L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFU2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKR0", "url": "https://www.uniprot.org/uniprotkb/F1MKR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKR0-1", "url": "https://www.uniprot.org/uniprotkb/F1MKR0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYFLSGWPKRLLCPLGSPAEAPFHVQSDPQRTFFAVLAPARLSIWYSRPSVLIVTYKEPAKSSSQFGSYKQAEWRPDSTMIAVSTANGYILFFHITSTRGDKYLYEPVYPKGSPQMKGTPHFKEEQCAPALNLEMKKILDLQAPIMSLQSVLEDLLVATSDGLLHLIHWEGMTNGRKAINLCTVPFSVDLQSSRGTGSFLGFADVHIRDMEYCATLDGFAVVFNDGKVGFITPVSSRFTAEQLHGVWPQDVVDGTCVAVNNKYRLMAFGCASGSVQVYTIDNTTGAMQLSHKLELTAKQYPDIWNKTGAVKLVRWSPDNSVVIVTWEYGGLSLWSVFGAQLICTLGGDFAYRSDGTKKDPLKINSMSWGAEGYHLWVISGFGSQNTENESDSKSIVKQPGILLFQFIKSALTVNPCMSNQEQVLLQGEDRLYLNCGEASQSQNPRSSSAHSDHRTRREKSPFAGGGLESQSLSTLLGHRHWHVVQISSTYLESNWPIRFSAIDKLGQNIAVVGKFGFAHYSLLTKKWKLFGNITQEQNMIVTGGLAWWNDFIVLACYNISDRQEELRVYLRTSNLDNAFAHVTKTQAETLLLSVFRDMVIVFRADCSICLYSIERKSDGPNAAGIQVLQEVSMSRYIPHPFLVVSVTLTSVSTENGITLKMPQQARDAESIMLNLAGQLIMMQRDRSGPQIREKDSNPNQRKLLPFCPPVVLAQSVENVWTTCRANKQKRHLLEALWLSCGGAGMKVWLPLFPRDHRKPHSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLLYDSLYSRNSAREQLEVLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCATLPYFPHVLELMLHEVLEEEATSREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGSGESETPPSTPTTQEPSSSGGGFEFFRNRSISLSQSADSVPASKFSLQKTLSMPSGPSGKRWSKDSDCAENMYIDMMLWRHARRLLEEVRLKDLGCFAAQLGFELISWLCKERARAARVDNFVLALKRLHKDFLWPLPIIPASSVSSPFKNGKYRTVGEQLLKSQSTDPFLNLEIDAGVSNVQRSQSWLGNIGPAHQEIDTASSHGPQMQDAFLSPLSNKGDECSIGSATDLTESSSMVDGDWTMVDENFSTLSLTQSELEHISMELASKGPHKSQVQLRYLLHIFMEAGCLDWCIVIGLILRESSIINQILVIIQSSEVDGEMLQNIKTGLHAVDRWASTDCPGYKPFLNIIKPHLQKLSEITEEQVQPEAFQPMTVGKTPEQTSPRAEENRSSLGHGSIPQGEVGGSSLVSRKEEDTTRAEEEEPFQDGTYDCSVS", "length": 1423, "header": "tr|F1MKR0-1|F1MKR0_BOVIN Isoform 1 of Guanine nucleotide exchange factor subunit RIC1 OS=Bos taurus OX=9913 GN=RIC1 PE=3 SV=3 CANONICAL=F1MKR0-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LYZ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LYZ0/entry", "sequence": { "sequence": "MYFLSGWPKRLLCPLGSPAEAPFHVQSDPQRTFFAVLAPARLSIWYSRTANGYILFFHITSTRGDKYLYEPVYPKGSPQMKGTPHFKEEQCAPALNLEMKKILDLQAPIMSLQSVLEDLLVATSDGLLHLIHWEGMTNGRKAINLCTVPFSVDLQSSRAGSFLGFADVHIRDMEYCATLDGFAVVFNDGKVGFITPVSSRFTAEQLHGVWPQDVVDGTCVAVNNKYRLMAFGCASGSVQVYTIDNTTGAMQLSHKLELTAKQYPDIWNKTGAVKLVRWSPDNSVVIVTWEYGGLSLWSVFGAQLICTLGGDFAYRSDGTKKDPLKINSMSWGAEGYHLWVISGFGSQNTENESDSKSIVKQPGILLFQFIKSALTVNPCMSNQEQVLLQGEDRLYLNCGEASQSQNPRSSSAHSDHRTRREKSPFAGGGLESQSLSTLLGHRHWHVVQISSTYLESNWPIRFSAIDKLGQNIAVVGKFGFAHYSLLTKKWKLFGNITQEQNMIVTGGLAWWNDFIVLACYNISDRQEELRVYLRTSNLDNAFAHVTKTQAETLLLSVFRDMVIVFRADCSICLYSIERKSDGPNAAGIQVLQEVSMSRYIPHPFLVVSVTLTSVSTENGITLKMPQQARDAESIMLNLAGQLIMMQRDRSGPQIREKDSNPNQRKLLPFCPPVVLAQSVENVWTTCRANKQKRHLLEALWLSCGGAGMKVWLPLFPRDHRKPHSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLLYDSLYSRNSAREQLEVLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCATLPYFPHVLELMLHEVLEEEATSREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGSGESETPPSTPTTQEPSSSGGGFEFFRNRSISLSQSADSVPASKFSLQKTLSMPSGPSGKRWSKDSDCAENMYIDMMLWRHARRLLEEVRLKDLGCFAAQLGFELISWLCKERARAARVDNFVLALKRLHKDFLWPLPIIPASSVSSPFKNGKYRTVGEQLLKSQSTDPFLNLEIDAGVSNVQRSQSWLGNIGPAHQEIDTASSHGPQMQDAFLSPLSNKGDECSIGSATDLTESSSMVDGDWTMVDENFSTLSLTQSELEHISMELASKGPHKSQVQLRYLLHIFMEAGCLDWCIVIGLILRESSIINQILVIIQSSEVDGEMLQNIKTGLHAVDRWASTDCPGYKPFLNIIKPHLQKLSEITEEQVQPEAFQPMTVGKTPEQTSPRAEENRSSLGHGSIPQGEVGGSSLVSRKEEDTTRAEEEEPFQDGTYDCSVS", "length": 1386, "header": "tr|A0A3Q1LYZ0-1|F1MKR0_BOVIN Computationally mapped isoform of Guanine nucleotide exchange factor subunit RIC1 OS=Bos taurus OX=9913 GN=RIC1 PE=3 SV=2 CANONICAL=F1MKR0-1" }, "locus": { "chromosome": "8", "start_pos": 39091202, "end_pos": 38949557, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081392.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081392.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062831.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062831.2" } ] } }, { "isoform_ac": "A0A3Q1M7F1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M7F1/entry", "sequence": { "sequence": "MYFLSGWPKRLLCPLGSPAEAPFHVQSDPQRTFFAVLAPARLSIWYSRPSVLIVTYKEPAKSSSQFGSYKQAEWRPDSTMIAVSTANGYILFFHITSTRGDKYLYEPVYPKGSPQMKGTPHFKEEQCAPALNLEMKKILDLQAPIMSLQSVLEDLLVATSDGLLHLIHWEGMTNGRKAINLCTVPFSVDLQSSRGSFLGFADVHIRDMEYCATLDGFAVVFNDGKVGFITPVSSRFTAEQLHGVWPQDVVDGTCVAVNNKYRLMAFGCASGSVQVYTIDNTTGAMQLSHKLELTAKQYPDVKNCNCKEGHTDLVEFLMGNADIWNKTGAVKLVRWSPDNSVVIVTWEYGGLSLWSVFGAQLICTLGGDFAYRSDGTKKDPLKINSMSWGAEGYHLWVISGFGSQNTENESDSKSIVKQPGILLFQFIKSALTVNPCMSNQEQVLLQGEDRLYLNCGEASQSQNPRSSSAHSDHRTRREKSPFAGGGLESQSLSTLLGHRHWHVVQISSTYLESNWPIRFSAIDKLGQNIAVVGKFGFAHYSLLTKKWKLFGNITQEQNMIVTGGLAWWNDFIVLACYNISDRQEELRVYLRTSNLDNAFAHVTKTQAETLLLSVFRDMVIVFRADCSICLYSIERKSDGPNAAGIQVLQEVSMSRYIPHPFLVVSVTLTSVSTENGITLKMPQQARDAESIMLNLAGQLIMMQRDRSGPQIREKDSNPNQRKLLPFCPPVVLAQSVENVWTTCRANKQKRHLLEALWLSCGGAGMKVWLPLFPRDHRKPHSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLLYDSLYSRNSAREQLEVLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCATLPYFPHVLELMLHEVLEEEATSREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGSGESETPPSTPTTQEPSSSGGGFEFFRNRSISLSQSADSVPASKFSLQKTLSMPSGPSGKRWSKDSDCAENMYIDMMLWRHARRLLEEVRLKDLGCFAAQLGFELISWLCKERARAARVDNFVLALKRLHKDFLWPLPIIPASSVSSPFKNGKYRTVGEQLLKSQSTDPFLNLEIDAGVSNVQRSQSWLGNIGPAHQEIDTASSHGPQMQDAFLSPLSNKGDECSIGSATDLTESSSMVDGDWTMVDENFSTLSLTQSELEHISMELASKGPHKSQVQLRYLLHIFMEAGCLDWCIVIGLILRESSIINQILVIIQSSEVDGEMLQNIKTGLHAVDRWASTDCPGYKPFLNIIKPHLQKLSEITEEQVQPEAFQPMTVGKTPEQTSPRAEENRSSLGHGSIPQGEVGGSSLVSRKEEDTTRAEEEEPFQDGTYDCSVS", "length": 1443, "header": "tr|A0A3Q1M7F1-1|F1MKR0_BOVIN Computationally mapped isoform of Guanine nucleotide exchange factor subunit RIC1 OS=Bos taurus OX=9913 GN=RIC1 PE=3 SV=2 CANONICAL=F1MKR0-1" }, "locus": { "chromosome": "8", "start_pos": 39091202, "end_pos": 38949557, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080494.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080494.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064332.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064332.2" } ] } }, { "isoform_ac": "A0A3Q1NBX6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBX6/entry", "sequence": { "sequence": "MYFLSGWPKRLLCPLGSPAEAPFHVQSDPQRTFFAVLAPARLSIWYSRPSVLIVTYKEPAKSSSQFGSYKQAEWRPDSTMIAVSTANGYILFFHITSTRGDKYLYEPVYPKGSPQMKGTPHFKEEQCAPALNLEMKKILDLQAPIMSLQSVLEDLLVATSDGLLHLIHWEGMTNGRKAINLCTVPFSVDLQSSRGTGSFLGFADVHIRDMEYCATLDGFAVVFNDGKVGFITPVSSRFTAEQLHGVWPQDVVDGTCVAVNNKYRLMAFGCASGSVQVYTIDNTTGAMQLSHKLELTAKQYPDIWNKTGAVKLVRWSPDNSVVIVTWEYGGLSLWSVFGAQLICTLGGDFAYRSDGTKKDPLKINSMSWGAEGYHLWVISGFGSQNTENESDSKSIVKQPGILLFQFIKSALTVNPCMSNQEQVLLQGEDRLYLNCGEASQSQNPRSSSAHSDHRTRREKSPFAGGGLESQSLSTLLGHRHWHVVQISSTYLESNWPIRFSAIDKLGQNIAVVGKFGFAHYSLLTKKWKLFGNITQLRVYLRTSNLDNAFAHVTKTQAETLLLSVFRDMVIVFRADCSICLYSIERKSDGPNAAGIQVLQEVSMSRYIPHPFLVVSVTLTSVSTENGITLKMPQQARDAESIMLNLAGQLIMMQRDRSGPQIREKDSNPNQRKLLPFCPPVVLAQSVENVWTTCRANKQKRHLLEALWLSCGGAGMKVWLPLFPRDHRKPHSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLLYDSLYSRNSAREQLEVLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCATLPYFPHVLELMLHEVLEEEATSREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGSGESETPPSTPTTQEPSSSGGGFEFFRNRSISLSQSADSVPASKFSLQKTLSMPSGPSGKRWSKDSDCAENMYIDMMLWRHARRLLEEVRLKDLGCFAAQLGFELISWLCKERARAARVDNFVLALKRLHKDFLWPLPIIPASSVSSPFKNGKYRTVGEQLLKSQSTDPFLNLEIDAGVSNVQRSQSWLGNIGPAHQEIDTASSHGPQMQDAFLSPLSNKGDECSIGSATDLTESSSMVDGDWTMVDENFSTLSLTQSELEHISMELASKGPHKSQVQLRYLLHIFMEAGCLDWCIVIGLILRESSIINQILVIIQSSEVDGEMLQNIKTGLHAVDRWASTDCPGYKPFLNIIKPHLQKLSEITEEQVQPEAFQPMTVGKTPEQTSPRAEENRSSLGHGSIPQGEVGGSSLVSRKEEDTTRAEEEEPFQDGTYDCSVS", "length": 1393, "header": "tr|A0A3Q1NBX6-1|F1MKR0_BOVIN Computationally mapped isoform of Guanine nucleotide exchange factor subunit RIC1 OS=Bos taurus OX=9913 GN=RIC1 PE=3 SV=2 CANONICAL=F1MKR0-1" }, "locus": { "chromosome": "8", "start_pos": 39091202, "end_pos": 38949557, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077593.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077593.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068856.2", "url": "https://www.ensembl.org/id/ENSBTAP00000068856.2" } ] } }, { "isoform_ac": "A0AAA9S5L5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5L5/entry", "sequence": { "sequence": "MTNLDSILKSRDITLPAKVHLVKAMVFPVVMCGCESWTVKKAERRRIDAFELWCWRRLLRVPWTARRSNQSILKEISPGISLEGMMLKLKLQYFGHLMRRVDSLEKTLMLGGIVDRRRRGRQRMRWLDGFTDSMDQLHGVWPQDVVDGTCVAVNNKYRLMAFGCASGSVQVYTIDNTTGAMQLSHKLELTAKQYPDIWNKTGAVKLVRWSPDNSVVIVTWEYGGLSLWSVFGAQLICTLGGDFAYRSDGTKKDPLKINSMSWGAEGYHLWVISGFGSQNTENESDSKSIVKQPGILLFQFIKSALTVNPCMSNQEQVLLQGEDRLYLNCGEASQSQNPRSSSAHSDHRTRREKSPFAGGGLESQSLSTLLGHRHWHVVQISSTYLESNWPIRFSAIDKLGQNIAVVGKFGFAHYSLLTKKWKLFGNITQEQNMIVTGGLAWWNDFIVLACYNISDRQEELRVYLRTSNLDNAFAHVTKTQAETLLLSVFRDMVIVFRADCSICLYSIERKSDGPNAAGIQVLQEVSMSRYIPHPFLVVSVTLTSVSTENGITLKMPQQARDAESIMLNLAGQLIMMQRDRSGPQIREKDSNPNQRKLLPFCPPVVLAQSVENVWTTCRANKQKRHLLEALWLSCGGAGMKVWLPLFPRDHRKPHSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLLYDSLYSRNSAREQLEVLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCATLPYFPHVLELMLHEVLEEEATSREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGSGESETPPSTPTTQEPSSSGGGFEFFRNRSISLSQSADSVPASKFSLQKTLSMPSGPSGKRWSKDSDCAENMYIDMMLWRHARRLLEEVRLKDLGCFAAQLGFELISWLCKERARAARVDNFVLALKRLHKDFLWPLPIIPASSVSSPFKNGKYRTVGEQLLKSQSTDPFLNLEIDAGVSNVQRSQSWLGNIGPAHQEIDTASSHGPQMQDAFLSPLSNKGDECSIGSATDLTESSSMVDGDWTMVDENFSTLSLTQSELEHISMELASKGPHKSQVQLRYLLHIFMEAGCLDWCIVIGLILRESSIINQILVIIQSSEVDGEMLQNIKTGLHAVDRWASTDCPGYKPFLNIIKPHLQKLSEITEEQVQPEAFQPMTVGKTPEQTSPRAEENRSSLGHGSIPQGEVGGSSLVSRKEEDTTRAEEEEPFQDGTYDCSVS", "length": 1317, "header": "tr|A0AAA9S5L5-1|F1MKR0_BOVIN Computationally mapped isoform of Guanine nucleotide exchange factor subunit RIC1 OS=Bos taurus OX=9913 GN=RIC1 PE=3 SV=1 CANONICAL=F1MKR0-1" }, "locus": { "chromosome": "8", "start_pos": 39002568, "end_pos": 38949557, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105750.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105750.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078568.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078568.1" } ] } }, { "isoform_ac": "A0AAA9SSQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSQ0/entry", "sequence": { "sequence": "MMTKGSPQMKGTPHFKEEQCAPALNLEMKKILDLQAPIMSLQSVLEDLLVATSDGLLHLIHWEGMTNGRKAINLCTVPFSVDLQSSRAGSFLGFADVHIRDMEYCATLDGFAVVFNDGKVGFITPVSSRFTAEQLHGVWPQDVVDGTCVAVNNKYRLMAFGCASGSVQVYTIDNTTGAMQLSHKLELTAKQYPDIWNKTGAVKLVRWSPDNSVVIVTWEYGGLSLWSVFGAQLICTLGGDFAYRSDGTKKDPLKINSMSWGAEGYHLWVISGFGSQNTENESDSKSIVKQPGILLFQFIKSALTVNPCMSNQEQVLLQGEDRLYLNCGEASQSQNPRSSSAHSDHRTRREKSPFAGGGLESQSLSTLLGHRHWHVVQISSTYLESNWPIRFSAIDKLGQNIAVVGKFGFAHYSLLTKKWKLFGNITQEQNMIVTGGLAWWNDFIVLACYNISDRQEELRVYLRTSNLDNAFAHVTKTQAETLLLSVFRDMVIVFRADCSICLYSIERKSDGPNAAGIQVLQEVSMSRYIPHPFLVVSVTLTSVSTENGITLKMPQQARDAESIMLNLAGQLIMMQRDRSGPQIREKDSNPNQRKLLPFCPPVVLAQSVENVWTTCRANKQKRHLLEALWLSCGGAGMKVWLPLFPRDHRKPHSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLLYDSLYSRNSAREQLEVLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCATLPYFPHVLELMLHEVLEEEATSREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGSGESETPPSTPTTQEPSSSGGGFEFFRNRSISLSQSADSVPASKFSLQKTLSMPSGPSGKRWSKDSDCAENMYIDMMLWRHARRLLEEVRLKDLGCFAAQLGFELISWLCKERARAARVDNFVLALKRLHKDFLWPLPIIPASSVSSPFKNGKYRTVGEQLLKSQSTDPFLNLEIDAGVSNVQRSQSWLGNIGPAHQEIDTASSHGPQMQDAFLSPLSNKGDECSIGSATDLTESSSMVDGDWTMVDENFSTLSLTQSELEHISMELASKGPHKSQVQLRYLLHIFMEAGCLDWCIVIGLILRESSIINQILVIIQSSEVDGEMLQNIKTGLHAVDRWASTDCPGYKPFLNIIKPHLQKLSEITEEQVQPEAFQPMTVGKTPEQTSPRAEENRSSLGHGSIPQGEVGGSSLVSRKEEDTTRAEEEEPFQDGTYDCSVS", "length": 1315, "header": "tr|A0AAA9SSQ0-1|F1MKR0_BOVIN Computationally mapped isoform of Guanine nucleotide exchange factor subunit RIC1 OS=Bos taurus OX=9913 GN=RIC1 PE=3 SV=1 CANONICAL=F1MKR0-1" }, "locus": { "chromosome": "8", "start_pos": 39015119, "end_pos": 38949557, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110409.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110409.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086056.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086056.1" } ] } }, { "isoform_ac": "A0AAA9TFU2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFU2/entry", "sequence": { "sequence": "MYFLSGWPKRLLCPLGSPAEAPFHVQSDPQRTFFAVLAPARLSIWYSRPSVLIVTYKEPAKSSSQFGSYKQAEWRPDSTMIAVSTANGYILFFHITSTRGDKYLYEPVYPKGSPQMKGTPHFKEEQCAPALNLEMKKILDLQAPIMSLQSVLEDLLVATSDGLLHLIHWEGMTNGRKAINLCTVPFSVDLQSSRAGSFLGFADVHIRDMEYCATLDGFAVVFNDGKVGFITPVSSRFTAEQLHGVWPQDVVDGTCVAVNNKYRLMAFGCASGSVQVYTIDNTTGAMQLSHKLELTAKQYPDIWNKTGAVKLVRWSPDNSVVIVTWEYGGLSLWSVFGAQLICTLGGDFAYRSDGTKKDPLKINSMSNQEQVLLQGEDRLYLNCGEASQSQNPRSSSAHSDHRTRREKSPFAGGGLESQSLSTLLGHRHWHVVQISSTYLESNWPIRFSAIDKLGQNIAVVGKFGFAHYSLLTKKWKLFGNITQEQNMIVTGGLAWWNDFIVLACYNISDRQEELRVYLRTSNLDNAFAHVTKTQAETLLLSVFRDMVIVFRADCSICLYSIERKSDGPNAAGIQVLQEVSMSRYIPHPFLVVSVTLTSVSTENGITLKMPQQARDAESIMLNLAGQLIMMQRDRSGPQIREKDSNPNQRKLLPFCPPVVLAQSVENVWTTCRANKQKRHLLEALWLSCGGAGMKVWLPLFPRDHRKPHSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLLYDSLYSRNSAREQLEVLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCATLPYFPHVLELMLHEVLEEEATSREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGSGESETPPSTPTTQEPSSSGGGFEFFRNRSISLSQSADSVPASKFSLQKTLSMPSGPSGKRWSKDSDCAENMYIDMMLWRHARRLLEEVRLKDLGCFAAQLGFELISWLCKERARAARVDNFVLALKRLHKDFLWPLPIIPASSVSSPFKNGKYRTVGEQLLKSQSTDPFLNLEIDAGVSNVQRSQSWLGNIGPAHQEIDTASSHGPQMQDAFLSPLSNKGDECSIGSATDLTESSSMVDGDWTMVDENFSTLSLTQSELEHISMELASKGPHKSQVQLRYLLHIFMEAGCLDWCIVIGLILRESSIINQILVIIQSSEVDGEMLQNIKTGLHAVDRWASTDCPGYKPFLNIIKPHLQKLSEITEEQVQPEAFQPMTVGKTPEQTSPRAEENRSSLGHGSIPQGEVGGSSLVSRKEEDTTRAEEEEPFQDGTYDCSVS", 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"length": 1423, "header": "tr|F1MKR0-1|F1MKR0_BOVIN Isoform 1 of Guanine nucleotide exchange factor subunit RIC1 OS=Bos taurus OX=9913 GN=RIC1 PE=3 SV=3 CANONICAL=F1MKR0-1" }, "locus": { "chromosome": "8", "start_pos": 39091202, "end_pos": 38949557, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001692.7", "url": "https://www.ensembl.org/id/ENSBTAT00000001692.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001692.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001692.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-6811438", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "resource": "Reactome", "description": "Intra-Golgi traffic" }, { "id": "R-BTA-6811440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "resource": "Reactome", "description": "Retrograde transport at the 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Classification" ] }, { "id": "IPR018957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042784", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042784", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M6C9", "url": "https://www.orthodb.org/?gene=A0A3Q1M6C9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1NI27", "url": "https://www.orthodb.org/?gene=A0A3Q1NI27", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MTR5", "url": "https://www.orthodb.org/?gene=F1MTR5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00097", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00097", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00622", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00622", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00643", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00643", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13765", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13765", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M6C9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6C9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M6C9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6C9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NI27", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NI27", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NI27-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NI27-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S093", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S093", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S093-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S093-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTR5", "url": "https://www.uniprot.org/uniprotkb/F1MTR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTR5-1", "url": "https://www.uniprot.org/uniprotkb/F1MTR5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASAASVTSLADEVNCPVCQGTLREPVTIDCGHNFCRVCLTRYLEITSPDPEEPPTCPLCKEPFRPGNFRPNWQLANVVENIERLKLVSQMDLDEEDVCPEHGEKVYFFCEDDEMQLCVVCREAWEHRAHTVRFLEDAAGPYRIFYAPSFQEQIQKCLECLRKEREEIQEIQSRENRRIQVLLTQVATKKQKVISEFAHLSQFLEEQQNILLDQLEKLDEDILKHRDEFDVLVTGEIGRFNTLIEELEEKKERPARELLTDIRSTLIRCETRRCRKPVAISPELGQRIRDFPQQAFPLQREMKMFLEKLSFELDYEPAHISLDPRTSHPKLLLSEDYQQARFSYKWQKSPDNPQRFDRATCVLAHGGFTGGRHTWVVSVDLAHGGSCTLGVVSKDIRRKGELRMRPEEGVWAVRLAWGFVSALNSFPTRLTLEEQPQQVRVSIDYEVGWVTFANAVTQEPIYTFTASFTQKVFPFFGLWGRGSKFSLSSQEGAATLS", "length": 497, "header": "tr|F1MTR5-1|F1MTR5_BOVIN Isoform 1 of Tripartite motif containing 10 OS=Bos taurus OX=9913 GN=TRIM10 PE=3 SV=3 CANONICAL=F1MTR5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M6C9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M6C9/entry", "sequence": { "sequence": "MASAASVTSLADEVNCPVCQGTLREPVTIDCGHNFCRVCLTRYLEITSPDPEEPPTCPLCKEPFRPGNFRPNWQLANVVENIERLKLVSQMDLDEEDVCPEHGEKVYFFCEDDEMQLCVVCREAWEHRAHTVRFLEDAAGPYREQIQKCLECLRKEREEIQEIQSRENRRIQVLLTQVATKKQKVISEFAHLSQFLEEQQNILLDQLEKLDEDILKHRDEFDVLVTGEIGRFNTLIEELEEKKERPARELLTVRAECETRRCRKPVAISPELGQRIRDFPQQAFPLQREMKMFLGKRTPWTHISLDPRTSHPKLLLSEDYQQARFSYKWQKSPDNPQRFDRATCVLAHGGFTGGRHTWVVSVDLAHGGSCTLGVVSKDIRRKGELRMRPEEGVWAVRLAWGFVSALNSFPTRLTLEEQPQQVRVSIDYEVGWVTFANAVTQEPIYTFTASFTQKVFPFFGLWGRGSKFSLSSQEGAATLS", "length": 480, "header": "tr|A0A3Q1M6C9-1|F1MTR5_BOVIN Computationally mapped isoform of Tripartite motif containing 10 OS=Bos taurus OX=9913 GN=TRIM10 PE=3 SV=1 CANONICAL=F1MTR5-1" }, "locus": { "chromosome": "23", "start_pos": 28824680, "end_pos": 28816924, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070730.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070730.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065922.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065922.1" } ] } }, { "isoform_ac": "A0A3Q1NI27-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NI27/entry", "sequence": { "sequence": "MASAASVTSLADEVNCPVCQGTLREPVTIDCGHNFCRVCLTRYLEITSPDPEEPPTCPLCKEPFRPGNFRPNWQLANVVENIERLKLVSQMDLDEEDVCPEHGEKVYFFCEDDEMQLCVVCREAWEHRAHTVRFLEDAAGPYRTQVATKKQKVISEFAHLSQFLEEQQNILLDQLEKLDEDILKHRDEFDVLVTGEIGRFNTLIEELEEKKERPARELLTDIRSTLIRCETRRCRKPVAISPELGQRIRDFPQQAFPLQREMKMFLEKLSFELDYEPAHISLDPRTSHPKLLLSEDYQQARFSYKWQKSPDNPQRFDRATCVLAHGGFTGGRHTWVVSVDLAHGGSCTLGVVSKDIRRKGELRMRPEEGVWAVRLAWGFVSALNSFPTRLTLEEQPQQVRVSIDYEVGWVTFANAVTQEPIYTFTASFTQKVFPFFGLWGRGSKFSLSSQEGAATLS", "length": 457, "header": "tr|A0A3Q1NI27-1|F1MTR5_BOVIN Computationally mapped isoform of Tripartite motif containing 10 OS=Bos taurus OX=9913 GN=TRIM10 PE=3 SV=2 CANONICAL=F1MTR5-1" }, "locus": { "chromosome": "23", "start_pos": 28824680, "end_pos": 28816924, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072283.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072283.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071652.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071652.2" } ] } }, { "isoform_ac": "A0AAA9S093-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S093/entry", "sequence": { "sequence": "MASAASVTSLADEVNCPVCQGTLREPVTIDCGHNFCRVCLTRYLEITSPDPEEPPTCPLCKEPFRPGNFRPNWQLANVVENIERLKLVSQMDLDEEDVCPEHGEKVYFFCEDDEMQLCVVCREAWEHRAHTVRFLEDAAGPYREQIQKCLECLRKEREEIQEIQSRENRRIQVLLTQVATKKQKVISEFAHLSQFLEEQQNILLDQLEKLDEDILKHRDEFDVLVTGEIGRFNTLIEELEEKKERPARELLTDIRSTLIRCETRRCRKPVAISPELGQRIRDFPQQAFPLQREMKMFLAHISLDPRTSHPKLLLSEDYQQARFSYKWQKSPDNPQRFDRATCVLAHGGFTGGRHTWVVSVDLAHGGSCTLGVVSKDIRRKGELRMRPEEGVWAVRLAWGFVSALNSFPTRLTLEEQPQQVRVSIDYEVGWVTFANAVTQEPIYTFTASFTQKVFPFFGLWGRGSKFSLSSQEGAATLS", "length": 478, "header": "tr|A0AAA9S093-1|F1MTR5_BOVIN Computationally mapped isoform of Tripartite motif containing 10 OS=Bos taurus OX=9913 GN=TRIM10 PE=3 SV=1 CANONICAL=F1MTR5-1" }, "locus": { "chromosome": "23", "start_pos": 28824680, "end_pos": 28816924, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090356.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090356.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076746.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076746.1" } ] } }, { "isoform_ac": "F1MTR5-1", "url": "https://www.uniprot.org/uniprotkb/F1MTR5/entry", "sequence": { "sequence": "MASAASVTSLADEVNCPVCQGTLREPVTIDCGHNFCRVCLTRYLEITSPDPEEPPTCPLCKEPFRPGNFRPNWQLANVVENIERLKLVSQMDLDEEDVCPEHGEKVYFFCEDDEMQLCVVCREAWEHRAHTVRFLEDAAGPYRIFYAPSFQEQIQKCLECLRKEREEIQEIQSRENRRIQVLLTQVATKKQKVISEFAHLSQFLEEQQNILLDQLEKLDEDILKHRDEFDVLVTGEIGRFNTLIEELEEKKERPARELLTDIRSTLIRCETRRCRKPVAISPELGQRIRDFPQQAFPLQREMKMFLEKLSFELDYEPAHISLDPRTSHPKLLLSEDYQQARFSYKWQKSPDNPQRFDRATCVLAHGGFTGGRHTWVVSVDLAHGGSCTLGVVSKDIRRKGELRMRPEEGVWAVRLAWGFVSALNSFPTRLTLEEQPQQVRVSIDYEVGWVTFANAVTQEPIYTFTASFTQKVFPFFGLWGRGSKFSLSSQEGAATLS", "length": 497, "header": "tr|F1MTR5-1|F1MTR5_BOVIN Isoform 1 of Tripartite motif containing 10 OS=Bos taurus OX=9913 GN=TRIM10 PE=3 SV=3 CANONICAL=F1MTR5-1" }, "locus": { "chromosome": "23", "start_pos": 28824680, "end_pos": 28816924, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000009909.6", "url": "https://www.ensembl.org/id/ENSBTAT00000009909.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000009909.5", "url": "https://www.ensembl.org/id/ENSBTAP00000009909.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MTR5", "url": "https://www.uniprot.org/uniprotkb/F1MTR5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MTR5", "url": "https://www.uniprot.org/uniprotkb/F1MTR5" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1MTR5", "url": "https://www.uniprot.org/uniprotkb/F1MTR5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "F1MTR5", "url": "https://www.uniprot.org/uniprotkb/F1MTR5" } ], "pmid": "" }, { "name": "host-mediated suppression of symbiont invasion", "id": "GO:0046597", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046597", "evidence": [ { "database": "UniProtKB", "id": "F1MTR5", "url": "https://www.uniprot.org/uniprotkb/F1MTR5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MTR5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 497, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MTR5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MTR5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTR5" }, { "id": "PS50119", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50119" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B box-type", "eco_id": "ECO_0000259", "start_pos": 94, "end_pos": 135, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTR5" }, { "id": "PS50188", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50188" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "B30.2/SPRY", "eco_id": "ECO_0000259", "start_pos": 300, "end_pos": 494, "start_aa": "Arg", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTR5" }, { "id": "PS50089", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50089" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RING-type", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 61, "start_aa": "Cys", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJZ1-1", "uniprot_ac": "F1MJZ1", "uniprot_id": "F1MJZ1_BOVIN", "mass": { "chemical_mass": 87829.0, "monoisotopic_mass": 87829.0 }, "refseq": {}, "gene_names": [ { "name": "VAC14", "type": "recommended", "evidence": [ { "id": "F1MJZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJZ1" } ] } ], "protein_names": [ { "name": "Protein VAC14 homolog", "type": "recommended", "evidence": [ { "id": "F1MJZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJZ1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.", "evidence": [ { "database": "UniProtKB", "id": "F1MJZ1", "url": "https://www.uniprot.org/uniprotkb/F1MJZ1#function" }, { "database": "UniProtKB", "id": "ARBA00045654", "url": "https://www.uniprot.org/uniprotkb/ARBA00045654#function" }, { "database": "UniProtKB", "id": "A0A3Q1MA21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA21#function" }, { "database": "UniProtKB", "id": "A0A3Q1MIG5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIG5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJZ1", "url": "https://www.uniprot.org/uniprotkb/F1MJZ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VAC14", "url": "https://www.uniprot.org/uniprotkb/F1MJZ1", "locus": { "chromosome": "18", "start_pos": 1487892, "end_pos": 1411469, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023795", "url": "https://www.ensembl.org/id/ENSBTAG00000023795" } ] } } ], "crossref": [ { "id": "F1MJZ1", "url": "https://alphafold.ebi.ac.uk/entry/F1MJZ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023795", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023795", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026825", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026825", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QCYQHVS", "url": "https://omabrowser.org/oma/group/QCYQHVS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MA21", "url": "https://www.orthodb.org/?gene=A0A3Q1MA21", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MIG5", "url": "https://www.orthodb.org/?gene=A0A3Q1MIG5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MJZ1", "url": "https://www.orthodb.org/?gene=F1MJZ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16023", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16023", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16023:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16023:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11916", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11916", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12755", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12755", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1660514", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660514", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1660516", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660516", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1660517", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660517", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MA21", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA21-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIG5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIG5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MIG5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIG5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJZ1", "url": "https://www.uniprot.org/uniprotkb/F1MJZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJZ1-1", "url": "https://www.uniprot.org/uniprotkb/F1MJZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVGFIPLLRERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKETKKSPSSVKFAEMANILVIHCQTTDDLIQLTAMCWLREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKRNIKEVASVCNQSLMKLVTPEDDEPDEPRPVVQKQAGPSPEDCAAKQEGAASGGPDGSCDSSFSSGISVFTPASAERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMSRHTDSLFPVLLQTLSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLRVSHSELQAPIPGRAGLLNTPGTKGLECSPSTPTMNSYFYKFMINLLKRFSSERKLLEVRGAFIIRQLCLLLHAESIFHSMADILLREEDLTFASTMVHTLNTILLTSTELFQLRNQLKDLKTPESRNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKSNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEDGLKAAPKSQKADSPSIDYAELLQHFERVQKKHLEVRHQRSGRGDHLDRRVVL", "length": 783, "header": "tr|F1MJZ1-1|F1MJZ1_BOVIN Isoform 1 of Protein VAC14 homolog OS=Bos taurus OX=9913 GN=VAC14 PE=3 SV=1 CANONICAL=F1MJZ1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MA21-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA21/entry", "sequence": { "sequence": "MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVGFIPLLRERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKETKKSPSSVKFAEMANILVIHCQTTDDLIQLTAMCWLREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKRNIKEVASVCNQSLMKLVTPEDDEPDEPRPVVQKQAGPSPEDCAAKQEGAASGGPDGSCDSSFSSGISVFTPASAERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMSRHTDSLFPVLLQTLSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLRVSHSELQAPIPGRAGLLNTPGTKGLECSPSTPTMNSYFYKFMINLLKRFSSERKLLEVRGAFIIRQLCLLLHAESIFHSMADILLREEDLTFASTMVHTLNTILLTSTELFQLRNQLKDLKTPESRNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKSNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEHLASEMENFTCQVAMETSRATEIYAEWSAPSLHQMPCASRIPSQAVQAPRQAGRLTPTRGLRPLPLRWTQAALRCPCAFCPAGPGAPPLPHLT", "length": 823, "header": "tr|A0A3Q1MA21-1|F1MJZ1_BOVIN Computationally mapped isoform of Protein VAC14 homolog OS=Bos taurus OX=9913 GN=VAC14 PE=3 SV=2 CANONICAL=F1MJZ1-1" }, "locus": { "chromosome": "18", "start_pos": 1484191, "end_pos": 1411733, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086902.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086902.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065353.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065353.2" } ] } }, { "isoform_ac": "A0A3Q1MIG5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MIG5/entry", "sequence": { "sequence": "MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVGFIPLLRERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKETKKSPSSVKFAEMANILVIHCQTTDDLIQLTAMCWLREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKRNIKEVASVCNQSLMKLVTPEDDEPDEPRPVVQKQAGPSPEDCAAKQEGAASGGPDGSCDSSFSSGISVFTPASGRSVAQSWVGGPCRGPGWRGHSHSPSPQMSRHTDSLFPVLLQTLSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLRVSHSELQAPIPGRAGLLNTPGTKGLECSPSTPTMNSYFYKFMINLLKRFSSERKLLEVRGAFIIRSLCLLLHAESIFHSMADILLREEDLTFASTMVHTLNTILLTSTELFQLRNQLKDLKTPESRNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKSNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEDGLKAAPKSQKADSPSIDYAELLQHFERVQKKHLEVRHQRSGRGDHLDRRVVL", "length": 763, "header": "tr|A0A3Q1MIG5-1|F1MJZ1_BOVIN Computationally mapped isoform of Protein VAC14 homolog OS=Bos taurus OX=9913 GN=VAC14 PE=3 SV=2 CANONICAL=F1MJZ1-1" }, "locus": { "chromosome": "18", "start_pos": 1487439, "end_pos": 1411733, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069310.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069310.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070505.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070505.2" } ] } }, { "isoform_ac": "F1MJZ1-1", "url": "https://www.uniprot.org/uniprotkb/F1MJZ1/entry", "sequence": { "sequence": "MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVGFIPLLRERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKETKKSPSSVKFAEMANILVIHCQTTDDLIQLTAMCWLREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKRNIKEVASVCNQSLMKLVTPEDDEPDEPRPVVQKQAGPSPEDCAAKQEGAASGGPDGSCDSSFSSGISVFTPASAERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMSRHTDSLFPVLLQTLSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLRVSHSELQAPIPGRAGLLNTPGTKGLECSPSTPTMNSYFYKFMINLLKRFSSERKLLEVRGAFIIRQLCLLLHAESIFHSMADILLREEDLTFASTMVHTLNTILLTSTELFQLRNQLKDLKTPESRNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKSNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEDGLKAAPKSQKADSPSIDYAELLQHFERVQKKHLEVRHQRSGRGDHLDRRVVL", "length": 783, "header": "tr|F1MJZ1-1|F1MJZ1_BOVIN Isoform 1 of Protein VAC14 homolog OS=Bos taurus OX=9913 GN=VAC14 PE=3 SV=1 CANONICAL=F1MJZ1-1" }, "locus": { "chromosome": "18", "start_pos": 1487439, "end_pos": 1411733, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032645.5", "url": "https://www.ensembl.org/id/ENSBTAT00000032645.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032574.2", "url": "https://www.ensembl.org/id/ENSBTAP00000032574.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1660514", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660514", "resource": "Reactome", "description": "Synthesis of PIPs at the Golgi membrane" }, { "id": "R-BTA-1660516", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660516", "resource": "Reactome", "description": "Synthesis of PIPs at the early endosome membrane" }, { "id": "R-BTA-1660517", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660517", "resource": "Reactome", "description": "Synthesis of PIPs at the late endosome membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZXU6-1", "protein_name": "Protein VAC14 homolog", "gene_name": "VAC14", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MNAERDLAPLAPSVVRALNDKLYEKRKVAALEIEKLVREFVAQNNTSQIKHVILILSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGSVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNQFDLVGFIPLLRERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNSKEIRKMCEVALGEFLKEIKKNPSSVKFAEMANILVIHCQAADDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLSYDDRKKNIKEVANVCNQSLMKLVIPEDDEMDEAKQSITLSAEPNPEEPVSKPEAASTGSLDVSGDSSVSNASVCTVTSSERIQVTLNLDGIVQVLDCHLHDTSIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLRTLSDESDEVILKDLEVLAEIASSPAGQTEGYGPSEAAEPRPGQVELHVPIRNSQLSSSGPKGLECSPSTPTMNSYFYKFMINLLKRFSSERKLLETRGAFIIRQLCLLLNAENIFHSMADILLREEDLKFASTMVHTLNTILLTSSELFQLRNQLKDLRTPESRNLFCCLYRSWCHNPVTTVSLCFLTQNYKHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKNNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELMQSAHLASGMENFTLWGRYGNRQSHGGRSEEAAPNASPRVRAPKGTAAGRARAPAGRRPPPSTTRSCCSTSTRSRASTWKCGTSGRGGQSSRSDAWCSEHGDEGTRTRARGRRRRRCF", "length": 841 }, "evidence": [ { "id": "F1MJZ1", "url": "https://omabrowser.org/oma/group/F1MJZ1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1S3E8-1", "protein_name": "Protein VAC14 homolog", "gene_name": "VAC14", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVGFIPLLRERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTTDDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDEPDEPKPVVQKQAEAKPEDSSAKQEGTASGGPDGSCDSSFGGSIGVFSPASTERAPVTLHLDGIVQVLNCHLSDMAIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQTLSDESDEVILKDLEVLAEIASSPAGQTDDAGPPDGPDLRVGHSELQVPTPGRASLLSTPGAKGLECSPSTPTMNSYFYKFMINLLKRFSSERKLLEVRGAFIIRQLCLLLNAENIFHSMADILLREEDLKFASTMVHTLNTILLTSTELFQLRNQLKDLRTPESRNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKNNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEDGLKAAPRSQNADSLSIDYAELLQHFERVQKKHLEVRHQRSGRGDHLDRRVVL", "length": 783 }, "evidence": [ { "id": "F1MJZ1", "url": "https://omabrowser.org/oma/group/F1MJZ1/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q06708-1", "protein_name": "Vacuole morphology and inheritance protein 14", "gene_name": "VAC14", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MEKSIAKGLSDKLYEKRKAAALELEKLVKQCVLEGDYDRIDKIIDELCRDYAYALHQPMARNAGLMGLAATAIALGINDVGRYLRNILPPVLACFGDQNDQVRFYACESLYNIAKIAKGEILVYFNEIFDVLCKISADTENSVRGAAELLDRLIKDIVAERASNYISIVNNGSHGLLPAIKTDPISGDVYQEEYEQDNQLAFSLPKFIPLLTERIYAINPDTRVFLVDWLKVLLNTPGLELISYLPSFLGGLFTFLGDSHKDVRTVTHTLMDSLLHEVDRISKLQTEIKMKRLERLKMLEDKYNNSSTPTKKADGALIAEKKKTLMTALGGLSKPLSMETDDTKLSNTNETDDERHLTSQEQLLDSEATSQEPLRDGEEYIPGQDINLNFPEVITVLVNNLASSEAEIQLIALHWIQVILSISPNVFIPFLSKILSVLLKLLSDSDPHITEIAQLVNGQLLSLCSSYVGKETDGKIAYGPIVNSLTLQFFDSRIDAKIACLDWLILIYHKAPNQILKHNDSMFLTLLKSLSNRDSVLIEKALSLLQSLCSDSNDNYLRQFLQDLLTLFKRDTKLVKTRANFIMRQISSRLSPERVYKVISSILDNYNDTTFVKMMIQILSTNLITSPEMSSLRNKLRTCEDGMFFNSLFKSWCPNPVSVISLCFVAENYELAYTVLQTYANYELKLNDLVQLDILIQLFESPVFTRMRLQLLEQQKHPFLHKCLFGILMIIPQSKAFETLNRRLNSLNIWTSQSYVMNNYIRQRENSNFCDSNSDISQRSVSQSKLHFQELINHFKAVSEEDEYSSDMIRLDHGANNKSLLLGSFLDGIDEDKQEIVTPISPMNEAINEEMESPNDNSSVILKDSGSLPFNRNVSDKLKK", "length": 880 }, "evidence": [ { "id": "F1MJZ1", "url": "https://omabrowser.org/oma/group/F1MJZ1/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q08AM6-1", "protein_name": "Protein VAC14 homolog", "gene_name": "VAC14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVSFIPLLRERIYSNNQYARQFIISWILVLESVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTTDDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDELDELRPGQRQAEPTPDDALPKQEGTASGGPDGSCDSSFSSGISVFTAASTERAPVTLHLDGIVQVLNCHLSDTAIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQTLSDESDEVILKDLEVLAEIASSPAGQTDDPGPLDGPDLQASHSELQVPTPGRAGLLNTSGTKGLECSPSTPTMNSYFYKFMINLLKRFSSERKLLEVRGPFIIRQLCLLLNAENIFHSMADILLREEDLKFASTMVHALNTILLTSTELFQLRNQLKDLKTLESQNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLAEVDKLVQLIECPIFTYLRLQLLDVKNNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEDSLKAAPKSQKADSPSIDYAELLQHFEKVQNKHLEVRHQRSGRGDHLDRRVVL", "length": 782 }, "evidence": [ { "id": "F1MJZ1", "url": "https://omabrowser.org/oma/group/F1MJZ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54HT3-1", "protein_name": "Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNNLSPIPSIVLKNLADKNTDKRKTGAQEIEQLIREHHSNDDQAVIRAIIKQISTEYTDSAQGNNKKGGLIGLASVAIGLGTDAYLYIQEIVPPVLRCFIDHDSRIRFYACESLFNIAKVTRSKILFFFNEIFDVLCKLSSDLDPQVKGGVQLFDRLLKDIVTESPTFDIDKFIPLLKERLYIINPFCRQFLVGWIIVLDSVPNIDMLIHLPKYLDGIFKMLRDQNKEIRNEADKALSEFLRELQTAENVDYGSMVKTIVPHCISSDEFTRLSALTWINEFILVGKKKLLPYCPLLLNGILSSLSHQLVNIEKMASLSNINLHKLILETNQDFPVGEFLNINTQHLISNSVQSRLASLNWILMLHSKLSSGISSYLTDLFPPLLKTLSDNSDEVVKLDLKTIAKISDNTELFDKLIQNLVILFSNDSQLLRTRGNFIIRQLCLFLNPELIFRRFSNILGNSGSGSGGNGNQDGNGENSKEINPEFASVMVQTLNLILLTSDECVEIRRNLRSLSTPESRDLFSVLYTSWAHSPASLFSLCMLCQVYEHSCALLSKFTEIEINVNFLMEMDRLVQLLESPKFMALRLQLLEPEKYPSLFKSLYGLLMILPQSSAFETLKNRLTCISSLGVLNLIPKKQNEDGNNSNNNEGLKDINFNNLLDHFKEIQVSHEKFYKDRNNQINNNNNNNNNNLDIETPFNQQRQLPYGIQSYINNKITNQQHQQQLTMSSPSSPITAPPPQVTTINSNFNNLNISSSSSSSSNNNSTGNNNNINNNNNNNNNINNNNFSSQPKDMSSSLPKYL", "length": 801 }, "evidence": [ { "id": "F1MJZ1", "url": "https://omabrowser.org/oma/group/F1MJZ1/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q80W92-1", "protein_name": "Protein VAC14 homolog", "gene_name": "Vac14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVRDFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESSKFDLVGFIPLLRERIYSNNQYARQFIISWILVLVSVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTTDDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDEPDEPKSVAQKQTEPNPEDSLPKQEGTASGGASGPCDSSFGSGISVFTSASTDRAPVTLHLDGIVQVLNCHLSDTTIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQTLSDESDEVVLKDLEVLAEIASSPAGQTDDPGAPDGPDLQVNHSELQVPTSGRANLLNPPNTKGLECSPSTPTMNSYFYKFMINLLQTFSSERKLLEARGPFIIRQLCLLLNAENIFHSMADILLREEDLKFASTMVHTLNTILLTSTELFQLRNQLKDLKTLESQNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKNNPYLMKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEDCLKAAPKSQKGDSPSIDYTELLQHFEKVQKQHLEVRHQRSGRGDHLDRRVVL", "length": 783 }, "evidence": [ { "id": "F1MJZ1", "url": "https://omabrowser.org/oma/group/F1MJZ1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q80WQ2-1", "protein_name": "Protein VAC14 homolog", "gene_name": "Vac14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVRDFVAQNNTMQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESSKFDLVSFIPLLRERIYSNNQYARQFIISWILVLVSVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTTDDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDEPDEPKSVAQKQTEPNPEDSLPKQEGTASGGPGSCDSSFGSGINVFTSANTDRAPVTLHLDGIVQVLNCHLSDTTIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQTLSDESDEVVLKDLEVLAEIASSPAGQTDDPGAPDGPDLRVNHSELQVPTSGRANLLNPPSTKGLEGSPSTPTMNSYFYKFMINLLQTFSSERKLLEARGPFIIRQLCLLLNAENIFHSMADILLREEDLKFASTMVHTLNTILLTSTELFQLRNQLKDLQTPESQNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKNNPYLIKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEDCLKAAPKSQKGDSPSIDYTELLQHFEKVQKQHLEVRHQRSGRGDHLDRRVIL", "length": 782 }, "evidence": [ { "id": "F1MJZ1", "url": "https://omabrowser.org/oma/group/F1MJZ1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VG59-1", "protein_name": "Protein VAC14 homolog", "gene_name": "Dmel\\CG5608", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEPPYAPLSESCAKALGDKVYEKRKLASQEIEKMVTEFNNKNNSAQIRKLIEVLATDYATSRDANRRKGALIGLAAMGLGLGKDSGKYVQGMVTPIMTCLSDPDIRVRYFACESLYNVVKVARSAIIPFFPELFAALSRLVTDSDQMVKDGSELLDRLLKDIVTESSQTFNLQAFIPLLREHIYVKDAFARQYVISWISILNAVPDINMVNYLTEILDGLFVMLEDNTLEIQRMCETTISQFLKSIRNDSSSVRMEDTINTLITHAQSPNELIKSIAITWIREFVQIFGPNVLPYASGIFTAILPCLEYNVESKRSIKECAVSVNNSMMLLVSTKELKTETVAKIDLRSIMDVLSQYLTHNSMHTKIAVLKWIHHLFTNFPNEMSVHASNLNTNLLSTLADNSDEVVLQSLSVLAEIVNSQESRELNDFNKSHYRKFLLSLLNLFSEEKLILENRASLIIRKLCVLLNAEYIYRTFAEIIAEGVPNLKFASTVVRLLNMILLTSTELFELRTSLRNISNEKSADLFQCLYKSWAHCPVSTLSLCLLTQSYQHVSRLVTLFADVEITLELLTEFDKLVQLIESPIFAPLRLTLVSKANNCADAQYLAHALFGILMLLPQTEAFDTLRNRLQCVPNYWGHEPVDERNSLEYKSGIDFDALEQHFIKLQKAHREQRIVHRKRSVITPESN", "length": 687 }, "evidence": [ { "id": "F1MJZ1", "url": "https://omabrowser.org/oma/group/F1MJZ1/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9ZU97-1", "protein_name": "Protein VAC14 homolog", "gene_name": "VAC14", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": 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"n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJZ1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 783, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJZ1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJZ1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJZ1" }, { "id": "PF11916", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11916" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Vacuolar protein 14 C-terminal Fig4-binding", "eco_id": "ECO_0000259", "start_pos": 543, "end_pos": 721, "start_aa": "Arg", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 325, "end_pos": 327 }, { "start_pos": 44, "end_pos": 46 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { 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"https://www.uniprot.org/uniprotkb/F1MNV2" } ] }, { "name": "ARHGEF3", "type": "synonym", "evidence": [ { "id": "XP_002697048", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697048" } ] } ], "protein_names": [ { "name": "Rho guanine nucleotide exchange factor 3", "type": "recommended", "evidence": [ { "id": "F1MNV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNV2/entry#names_and_taxonomy" } ] }, { "name": "rho guanine nucleotide exchange factor 3 isoform X5", "type": "synonym", "evidence": [ { "id": "XP_002697048", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697048" } ] } ], "function": [ { "annotation": "Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1N8V0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V0#function" }, { "database": "UniProtKB", "id": "ARBA00043905", "url": 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"categories": [ "Protein Classification" ] }, { "id": "PF00621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22697", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22697", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-416482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002697048", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697048", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA88", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA88-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MH59", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH59", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MH59-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH59-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMQ5", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMQ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MMQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMQ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQJ3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MQJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N8V0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N8V0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTD0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTD0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RTD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTD0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THA4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9THA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NT63", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT63", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NT63-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT63-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P0Y9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0Y9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P0Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0Y9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNV2", "url": "https://www.uniprot.org/uniprotkb/F1MNV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNV2-1", "url": "https://www.uniprot.org/uniprotkb/F1MNV2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVAKDYPFYLTVKRANCSLEVPPASSPAKDAEEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDLLGPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDNSKVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPMKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCATGQAAALDSEGPFLDPATRSREPQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHVESNV", "length": 526, "header": "tr|F1MNV2-1|F1MNV2_BOVIN Isoform 1 of Rho guanine nucleotide exchange factor 3 OS=Bos taurus OX=9913 GN=ARHGEF3 PE=4 SV=2 CANONICAL=F1MNV2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MA88-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA88/entry", "sequence": { "sequence": "MWPTVCISWGCHVTTCRKETWICDTASVDNSRVMNQCAFRGMEENTERPKRQRQNNFPMFPSPKDWNFRGRKRKQSTQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDLLGPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDNSKVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPMKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCATGQAAALDSEGPFLDPATRSREPQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHVESNV", "length": 585, "header": "tr|A0A3Q1MA88-1|F1MNV2_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 3 OS=Bos taurus OX=9913 GN=ARHGEF3 PE=4 SV=2 CANONICAL=F1MNV2-1" }, "locus": { "chromosome": "22", "start_pos": 44329103, "end_pos": 44043809, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068976.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068976.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067127.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067127.2" } ] } }, { "isoform_ac": "A0A3Q1MH59-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MH59/entry", "sequence": { "sequence": "MNQCAFRGMEENTESVPSFRRSQAGRGRTSPVLLKAAPRRFRNSICRPKRQRQNNFPMFPSPKDWNFRGRKRKQSTQDEDAPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDLLGPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDNSKVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPMKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCATGQAAALDSEGPFLDPATRSREPQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHVESNV", "length": 574, "header": "tr|A0A3Q1MH59-1|F1MNV2_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 3 OS=Bos taurus OX=9913 GN=ARHGEF3 PE=4 SV=1 CANONICAL=F1MNV2-1" }, "locus": { "chromosome": "22", "start_pos": 44329103, "end_pos": 44052099, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069507.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069507.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073572.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073572.2" } ] } }, { "isoform_ac": "A0A3Q1MMQ5-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MMQ5/entry", "sequence": { "sequence": "MRSERPMVWCCFFVRTQRKRKQSTQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDLLGPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDNSKVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPMKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCATGQAAALDSEGPFLDPATRSREPQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHVESNV", "length": 532, "header": "tr|A0A3Q1MMQ5-1|F1MNV2_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 3 OS=Bos taurus OX=9913 GN=ARHGEF3 PE=4 SV=1 CANONICAL=F1MNV2-1" }, "locus": { "chromosome": "22", "start_pos": 44329103, "end_pos": 44152760, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072941.3", "url": "https://www.ensembl.org/id/ENSBTAT00000072941.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072461.1", "url": "https://www.ensembl.org/id/ENSBTAP00000072461.1" } ] } }, { "isoform_ac": "A0A3Q1MQJ3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MQJ3/entry", "sequence": { "sequence": "MDRALKGLVIGYMDRPKRQRQNNFPMFPSPKDWNFRGRKRKQSTQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDLLGPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDNSKVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPMKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCATGQAAALDSEGPFLDPATRSREPQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHVESNV", "length": 552, "header": "tr|A0A3Q1MQJ3-1|F1MNV2_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 3 OS=Bos taurus OX=9913 GN=ARHGEF3 PE=4 SV=2 CANONICAL=F1MNV2-1" }, "locus": { "chromosome": "22", "start_pos": 44329103, "end_pos": 44087387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074958.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074958.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072028.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072028.2" } ] } }, { "isoform_ac": "A0A3Q1N8V0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N8V0/entry", "sequence": { "sequence": "VDNSRVMNQCAFRGMEENTERPKRQRQNNFPMFPSPKDWNFRGRKRKQSTQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDLLGPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDNSKVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPMKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCATGQAAALDSEGPFLDPATRSREPQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHVESNV", "length": 558, "header": "tr|A0A3Q1N8V0-1|F1MNV2_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 3 OS=Bos taurus OX=9913 GN=ARHGEF3 PE=4 SV=3 CANONICAL=F1MNV2-1" }, "locus": { "chromosome": "22", "start_pos": 44329103, "end_pos": 44052081, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077427.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077427.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067512.3", "url": "https://www.ensembl.org/id/ENSBTAP00000067512.3" } ] } }, { "isoform_ac": "A0AAA9RTD0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTD0/entry", "sequence": { "sequence": "MRKETWICDTASVDNSRVMNQCAFRGMEENTERPKRQRQNNFPMFPSPKDWNFRGRKRKQSTQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDLLGPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDNSKVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPMKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCATGQAAALDSEGPFLDPATRSREPQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHVESNV", "length": 570, "header": "tr|A0AAA9RTD0-1|F1MNV2_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 3 OS=Bos taurus OX=9913 GN=ARHGEF3 PE=4 SV=1 CANONICAL=F1MNV2-1" }, "locus": { "chromosome": "22", "start_pos": 44329103, "end_pos": 44020806, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114307.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114307.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076176.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076176.1" } ] } }, { "isoform_ac": "A0AAA9THA4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9THA4/entry", "sequence": { "sequence": "MESWTGKETWICDTASVDNSRVMNQCAFRGMEENTERPKRQRQNNFPMFPSPKDWNFRGRKRKQSTQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDLLGPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDNSKVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPMKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCATGQAAALDSEGPFLDPATRSREPQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHVESNV", "length": 574, "header": "tr|A0AAA9THA4-1|F1MNV2_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 3 OS=Bos taurus OX=9913 GN=ARHGEF3 PE=4 SV=1 CANONICAL=F1MNV2-1" }, "locus": { "chromosome": "22", "start_pos": 44329103, "end_pos": 44016021, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108118.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108118.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096450.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096450.1" } ] } }, { "isoform_ac": "A0ABI0NT63-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NT63/entry", "sequence": { "sequence": "MNTLRLPLEMVEFHHNHWPVWLFPSKFGVFMRCPASPARQMELRKTREPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDLLGPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDNSKVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPMKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCATGQAAALDSEGPFLDPATRSREPQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHVESNV", "length": 541, "header": "tr|A0ABI0NT63-1|A0ABI0NT63_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 3 OS=Bos taurus OX=9913 GN=ARHGEF3 PE=4 SV=1 CANONICAL=F1MNV2-1" }, "locus": { "chromosome": "22", "start_pos": 44329103, "end_pos": 44287484, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000149765.1", "url": "https://www.ensembl.org/id/ENSBTAT00000149765.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106404.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106404.1" } ] } }, { "isoform_ac": "A0ABI0P0Y9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0Y9/entry", "sequence": { "sequence": "MHRKRKQSTQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDLLGPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDNSKVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPMKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCATGQAAALDSEGPFLDPATRSREPQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHVESNV", "length": 517, "header": "tr|A0ABI0P0Y9-1|A0ABI0P0Y9_BOVIN Computationally mapped isoform of Rho guanine nucleotide exchange factor 3 OS=Bos taurus OX=9913 GN=ARHGEF3 PE=4 SV=1 CANONICAL=F1MNV2-1" }, "locus": { "chromosome": "22", "start_pos": 44329103, "end_pos": 44027915, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000139741.1", "url": "https://www.ensembl.org/id/ENSBTAT00000139741.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107504.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107504.1" } ] } }, { "isoform_ac": "F1MNV2-1", "url": "https://www.uniprot.org/uniprotkb/F1MNV2/entry", "sequence": { "sequence": "MVAKDYPFYLTVKRANCSLEVPPASSPAKDAEEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDLLGPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDNSKVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPMKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCATGQAAALDSEGPFLDPATRSREPQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHVESNV", "length": 526, "header": "tr|F1MNV2-1|F1MNV2_BOVIN Isoform 1 of Rho guanine nucleotide exchange factor 3 OS=Bos taurus OX=9913 GN=ARHGEF3 PE=4 SV=2 CANONICAL=F1MNV2-1" }, "locus": { "chromosome": "22", "start_pos": 44329103, "end_pos": 44262769, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018734.8", "url": "https://www.ensembl.org/id/ENSBTAT00000018734.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018734.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018734.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:782247", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:782247", "resource": "KEGG Pathway" }, { "id": "R-BTA-416482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BP24-1", "protein_name": "Rho guanine nucleotide exchange factor 3", "gene_name": "ARHGEF3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MVAKDYPFYLTVKRANCSLEVPPASSPAKDAEEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGPFLDPATRGRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHVESNV", "length": 526 }, "evidence": [ { "id": "F1MNV2", "url": "https://omabrowser.org/oma/group/F1MNV2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LKT1-1", "protein_name": "Rho guanine nucleotide exchange factor 3", "gene_name": "Arhgef3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MRSERPMVWCCFFLRAQRKRKQSTQDEDAISLCSLDISEPSNKRVKPLSRVTSLANLIPPVKTTPLKRFSQTLQRSISFRSESRPDILAPRAWSRNATSSSTKRRDSKLWSETFDVCVNQVLTAKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEDLLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDDPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLMLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLSAAGQAGLLDSEGILLGPGTENREPQGETKLEQMDQSDSESDCSMDTSEVSLECERMEQTDVSCANSRPEESV", "length": 531 }, "evidence": [ { "id": "F1MNV2", "url": "https://omabrowser.org/oma/group/F1MNV2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8M2B905-1", "protein_name": "Rho guanine nucleotide exchange factor 3", "gene_name": "arhgef3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSAGGDEASGPMVQGKESFSLLSTSEKWLFKGKKRKQRKRDVDSLSLCSLDINEPSTKRVKPLSRVTSLASLIPPVKAAPLKRIGQTLQRSISFRSVCRPEIMAPRPWSRQVVPTVTKRRDSKLWSETFDVGLGHMLSSKEIKRQEAIFELSQGEQDLIEDLKLAKKAYHDPMLKLCIMTEHELNQIFGTLDSLIPLHEDLLSRLRDVRNPDGSTDHMGHILVHWLPCLETYNSYCSNQVAAKALLDHKKQDHRVHDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILKHTPNEHPDRQHLDEAINMIQSIVARINTQTGESECRYYKERLLYLESGQRDLLIESSRILICHGELKNNRGVKLHVFLFQDVLVITRAISHNEQLWYQLYRQPIPVRDLEWEDLQDGEMRVGGSIRGAFSNNERTKNFFRVMFRCGGQTQMHCFQASDTFNKQQWLNCIRQAKEAVGSAESEPPRSPQMDRERQHNDCSDTMEDSSSEYPQMELADIPVSPVRE", "length": 520 }, "evidence": [ { "id": "F1MNV2", "url": "https://omabrowser.org/oma/group/F1MNV2/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q91X46-1", "protein_name": "Rho guanine nucleotide exchange factor 3", "gene_name": "Arhgef3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVAKDYPFYLTVKRANCSLEAPLGSGVAKDEEPSNKRVKPLSRVTSLANLIPPVKTTPLKRFSQTLQRSISFRSESRPDILAPRAWSRNATSSSTKRRDSKLWSETFDVCVNQVLTAKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLTLEDLQDGEVRLGGSLRGAFSNNERVKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLSAAGQAGLLDSEGLVQGPGTENREPQGETKLEQMDQSDSESDCSMDTSEVSLECERMEQTDASCANSRPEESV", "length": 524 }, "evidence": [ { "id": "F1MNV2", "url": "https://omabrowser.org/oma/group/F1MNV2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NR81-1", "protein_name": "Rho guanine nucleotide exchange factor 3", "gene_name": "ARHGEF3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVAKDYPFYLTVKRANCSLELPPASGPAKDAEEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHGESNV", "length": 526 }, "evidence": [ { "id": "F1MNV2", "url": "https://omabrowser.org/oma/group/F1MNV2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MNV2", "url": "https://www.uniprot.org/uniprotkb/F1MNV2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1MNV2", "url": "https://www.uniprot.org/uniprotkb/F1MNV2" } ], "pmid": "" }, { "name": "positive regulation of Rho protein signal transduction", "id": "GO:0035025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035025", "evidence": [ { "database": "UniProtKB", "id": "F1MNV2", "url": "https://www.uniprot.org/uniprotkb/F1MNV2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "F1MNV2", "url": "https://www.uniprot.org/uniprotkb/F1MNV2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 420, "end_pos": 422, "annotation": "n_glycosylation_sequon" }, { "start_pos": 432, "end_pos": 434, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MNV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNV2" }, { "id": "PS50010", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50010" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DH", "eco_id": "ECO_0000259", "start_pos": 122, "end_pos": 304, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MNV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNV2" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 291, "end_pos": 449, "start_aa": "Ile", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 16, "end_pos": 18 }, { "start_pos": 420, "end_pos": 422 }, { "start_pos": 432, "end_pos": 434 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"monoisotopic_mass": 152090.0 }, "refseq": { "ac": "XP_024845903", "name": "zinc finger FYVE domain-containing protein 9 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845903" }, "gene_names": [ { "name": "ZFYVE9", "type": "recommended", "evidence": [ { "id": "F1MKY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY4" } ] }, { "name": "ZFYVE9", "type": "synonym", "evidence": [ { "id": "XP_024845903", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845903" } ] } ], "protein_names": [ { "name": "Zinc finger FYVE domain-containing protein", "type": "recommended", "evidence": [ { "id": "F1MKY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY4/entry#names_and_taxonomy" } ] }, { "name": "zinc finger FYVE domain-containing protein 9 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024845903", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845903" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MKY4", "url": "https://www.uniprot.org/uniprotkb/F1MKY4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ZFYVE9", "url": "https://www.uniprot.org/uniprotkb/F1MKY4", "locus": { "chromosome": "3", "start_pos": 94017749, "end_pos": 94201241, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014289", "url": "https://www.ensembl.org/id/ENSBTAG00000014289" } ] } } ], "crossref": [ { "id": "ENSBTAG00000014289", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014289", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15729", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15729", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "613428", "url": "https://www.ncbi.nlm.nih.gov/gene/613428", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "F1MKY4", "url": "https://www.ebi.ac.uk/intact/interactors/id:F1MKY4*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000306", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000306", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022557", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022557", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MB29", "url": "https://www.orthodb.org/?gene=A0A3Q1MB29", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MKY4", "url": "https://www.orthodb.org/?gene=F1MKY4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46319", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46319", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46319:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46319:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01363", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01363", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11409", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11409", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11979", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11979", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2173789", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173789", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024845903", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845903", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MB29", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB29", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MB29-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB29-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKY4", "url": "https://www.uniprot.org/uniprotkb/F1MKY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKY4-1", "url": "https://www.uniprot.org/uniprotkb/F1MKY4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MENYFQAEAYNLDKVLDEFEQNEDETVSPILLDTKWNKILDPSSRQLSFNSALTSVNEPTVSESQPQLKVFSLAHSAPPDSEGEDHCANGQDCSLNPEINTMWIDENAVTEDQLIKRNCSRDDQCSTVEVGEKKCGNLACLPDEKNVLVVAVMHNCDKRTFQSDLQDCNNYNSQSLKNAFSCSLDNENRQTDQFSFSINGSTEKDMNSEKQMDPLNRPNAEGDSDKYICTTSDNLASVCSPSQLQDDENIDRDPSMSVITSLTLDSVISSQRTEEGPDVKQEDSTPDEVLTGKTSSPRTDLGSPNSFSHLSEEILMKKEPSEERTTEESTQSALPLLLKTDMPNGSGRDDNSEQVSDCLVPSEGKADDKEGCKHEEILGTKEFLNMTEHFSESQEMTNWKLTKPNKMNDSQVKKDNEKFLQMNQPEDTCDDSGECDRMAEAGLDLKGTCVNESEGCDFSTVMDTPAANSLSNCCDSYGMQSPVVCFVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNEATEGSGLLLNSTGDLTKKNYLHNFCSQVPSVLGQSSPKIVANLQSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDLPANSGNTAKNKNDVLGKAKLGENSATNVCNASSGNISIADTNGDHLESYESGISSRPCLALAPESPDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASSQSPNPNNPAEYCSTIPPLQQAQASGALSSPPPTVMVPVGVLKHPGAEGTLAVAHDPVKPAATSPLPAETNISLFSGSITQVGSPVGSAMNLIPEDGLPPILISTGVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYVNRKCWCFTTKGMHAVGQSEIVILLQCLPDEKCLPKDIFNHFVQLYRDALAGNVVGNLGHSFFSQSFLGSKEHGGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRLMLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTSIKIPSNRYNEMIKAMNKSNEHVLAGGACFNEKADSHLVCVQNDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDALRQALREMKDFTITCGKAEAEDPQEQIHIQWVDDDKDVNKGVLSPIDGKSMESITSVKIFHGSEYKANGKVIRWTEVFFLENDDQHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPSQYMNDLDSALVPVIHGGACQLSEGPIVMELIFYILENIA", "length": 1385, "header": "tr|F1MKY4-1|F1MKY4_BOVIN Isoform 1 of Zinc finger FYVE domain-containing protein OS=Bos taurus OX=9913 GN=ZFYVE9 PE=4 SV=4 CANONICAL=F1MKY4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MB29-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MB29/entry", "sequence": { "sequence": "MENYFQAEAYNLDKVLDEFEQNEDETVSPILLDTKWNKILDPSSRQLSFNSALTSVNEPTVSESQPQLKVFSLAHSAPPDSEGEDHCANGQDCSLNPEINTMWIDENAVTEDQLIKRNCSRDDQCSTVEVGEKKCGNLACLPDEKNVLVVAVMHNCDKRTFQSDLQDCNNYNSQSLKNAFSCSLDNENRQTDQFSFSINGSTEKDMNSEKQMDPLNRPNAEGDSDKYICTTSDNLASVCSPSQLQDDENIDRDPSMSVITSLTLDSVISSQRTEEGPDVKQEDSTPDEVLTGKTSSPRTDLGSPNSFSHLSEEILMKKEPSEERTTEESTQSALPLLLKTDMPNGSGRDDNSEQVSDCLVPSEGKADDKEGCKHEEILGTKEFLNMTEHFSESQEMTNWKLTKPNKMNDSQVKKDNEKFLQMNQPEDTCDDSGECDRMAEAGLDLKGTCVNESEGCDFSTVMDTPAANSLSNCCDSYGMQSPVVCFVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNEATEGSGLLLNSTGDLTKKNYLHNFCSQVPSVLGQSSPKIVANLQSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDLPANSGNTAKNKNDVLGKAKLGENSATNVCNASSGNISIADTNGDHLESYESGISSRPCLALAPESPDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNVAQPREQRRVWFADGILPNGEVADAAKLTMNGTSSAGTLAVAHDPVKPAATSPLPAETNISLFSGSITQVGSPVGSAMNLIPEDGLPPILISTGVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYVNRKCWCFTTKGMHAVGQSEIVILLQCLPDEKCLPKDIFNHFVQLYRDALAGNVVGNLGHSFFSQSFLGSKEHGGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRLMLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTSIKIPSNRYNEMIKAMNKSNEHVLAGGACFNEKADSHLVCVQNDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDALRQALREMKDFTITCGKAEAEDPQEQIHIQWVDDDKDVNKGVLSPIDGKSMESITSVKIFHGSEYKANGKVIRWTEVFFLENDDQHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPSQYMNDLDSALVPVIHGGACQLSEGPIVMELIFYILENIA", "length": 1362, "header": "tr|A0A3Q1MB29-1|F1MKY4_BOVIN Computationally mapped isoform of Zinc finger FYVE domain-containing protein OS=Bos taurus OX=9913 GN=ZFYVE9 PE=4 SV=1 CANONICAL=F1MKY4-1" }, "locus": { "chromosome": "3", "start_pos": 94114393, "end_pos": 94018753, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072453.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072453.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067852.1", "url": "https://www.ensembl.org/id/ENSBTAP00000067852.1" } ] } }, { "isoform_ac": "F1MKY4-1", "url": "https://www.uniprot.org/uniprotkb/F1MKY4/entry", "sequence": { "sequence": "MENYFQAEAYNLDKVLDEFEQNEDETVSPILLDTKWNKILDPSSRQLSFNSALTSVNEPTVSESQPQLKVFSLAHSAPPDSEGEDHCANGQDCSLNPEINTMWIDENAVTEDQLIKRNCSRDDQCSTVEVGEKKCGNLACLPDEKNVLVVAVMHNCDKRTFQSDLQDCNNYNSQSLKNAFSCSLDNENRQTDQFSFSINGSTEKDMNSEKQMDPLNRPNAEGDSDKYICTTSDNLASVCSPSQLQDDENIDRDPSMSVITSLTLDSVISSQRTEEGPDVKQEDSTPDEVLTGKTSSPRTDLGSPNSFSHLSEEILMKKEPSEERTTEESTQSALPLLLKTDMPNGSGRDDNSEQVSDCLVPSEGKADDKEGCKHEEILGTKEFLNMTEHFSESQEMTNWKLTKPNKMNDSQVKKDNEKFLQMNQPEDTCDDSGECDRMAEAGLDLKGTCVNESEGCDFSTVMDTPAANSLSNCCDSYGMQSPVVCFVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNEATEGSGLLLNSTGDLTKKNYLHNFCSQVPSVLGQSSPKIVANLQSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDLPANSGNTAKNKNDVLGKAKLGENSATNVCNASSGNISIADTNGDHLESYESGISSRPCLALAPESPDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASSQSPNPNNPAEYCSTIPPLQQAQASGALSSPPPTVMVPVGVLKHPGAEGTLAVAHDPVKPAATSPLPAETNISLFSGSITQVGSPVGSAMNLIPEDGLPPILISTGVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYVNRKCWCFTTKGMHAVGQSEIVILLQCLPDEKCLPKDIFNHFVQLYRDALAGNVVGNLGHSFFSQSFLGSKEHGGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRLMLRLGAEYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTSIKIPSNRYNEMIKAMNKSNEHVLAGGACFNEKADSHLVCVQNDDGNYQTQAISIHNQPRKVTGASFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDALRQALREMKDFTITCGKAEAEDPQEQIHIQWVDDDKDVNKGVLSPIDGKSMESITSVKIFHGSEYKANGKVIRWTEVFFLENDDQHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNGQPLPSQYMNDLDSALVPVIHGGACQLSEGPIVMELIFYILENIA", "length": 1385, "header": "tr|F1MKY4-1|F1MKY4_BOVIN Isoform 1 of Zinc finger FYVE domain-containing protein OS=Bos taurus OX=9913 GN=ZFYVE9 PE=4 SV=4 CANONICAL=F1MKY4-1" }, "locus": { "chromosome": "3", "start_pos": 94114393, "end_pos": 94018753, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018986.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018986.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018986.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018986.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1010, "start_aa": "Thr", "end_pos": 1010, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1010", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-2173789", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2173789", "resource": "Reactome", "description": "TGF-beta receptor signaling activates SMADs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MKY4", "url": "https://www.uniprot.org/uniprotkb/F1MKY4" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "F1MKY4", "url": "https://www.uniprot.org/uniprotkb/F1MKY4" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "F1MKY4", "url": "https://www.uniprot.org/uniprotkb/F1MKY4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MKY4", "url": "https://www.uniprot.org/uniprotkb/F1MKY4" } ], "pmid": "" }, { "name": "1-phosphatidylinositol binding", "id": "GO:0005545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005545", "evidence": [ { "database": "UniProtKB", "id": "F1MKY4", "url": "https://www.uniprot.org/uniprotkb/F1MKY4" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "F1MKY4", "url": "https://www.uniprot.org/uniprotkb/F1MKY4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "transforming growth factor beta receptor signaling pathway", "id": "GO:0007179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007179", "evidence": [ { "database": "UniProtKB", "id": "F1MKY4", "url": "https://www.uniprot.org/uniprotkb/F1MKY4" } ], "pmid": "" }, { "name": "endosomal transport", "id": "GO:0016197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016197", "evidence": [ { "database": "UniProtKB", "id": "F1MKY4", "url": "https://www.uniprot.org/uniprotkb/F1MKY4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1112, "end_pos": 1114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 118, "end_pos": 120, "annotation": "n_glycosylation_sequon" }, { "start_pos": 199, "end_pos": 201, "annotation": "n_glycosylation_sequon" }, { "start_pos": 344, "end_pos": 346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 385, "end_pos": 387, "annotation": "n_glycosylation_sequon" }, { "start_pos": 408, "end_pos": 410, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" }, { "start_pos": 532, "end_pos": 534, "annotation": "n_glycosylation_sequon" }, { "start_pos": 629, "end_pos": 631, "annotation": "n_glycosylation_sequon" }, { "start_pos": 634, "end_pos": 636, "annotation": "n_glycosylation_sequon" }, { "start_pos": 837, "end_pos": 839, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1010 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1112, "end_pos": 1114 }, { "start_pos": 118, "end_pos": 120 }, { "start_pos": 199, "end_pos": 201 }, { "start_pos": 344, "end_pos": 346 }, { "start_pos": 385, "end_pos": 387 }, { "start_pos": 408, "end_pos": 410 }, { "start_pos": 451, "end_pos": 453 }, { "start_pos": 532, "end_pos": 534 }, { "start_pos": 629, "end_pos": 631 }, { "start_pos": 634, "end_pos": 636 }, { "start_pos": 837, "end_pos": 839 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMK3-1", "uniprot_ac": "F1MMK3", "uniprot_id": "F1MMK3_BOVIN", "mass": { "chemical_mass": 82584.0, "monoisotopic_mass": 82584.0 }, "refseq": { "ac": "NP_001192982", "name": "ATP-dependent RNA helicase DDX50", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192982" }, "gene_names": [ { "name": "DDX50", "type": "recommended", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "name": "DDX50", "type": "synonym", "evidence": [ { "id": "NP_001192982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192982" } ] } ], "protein_names": [ { "name": "ATP-dependent RNA helicase DDX50", "type": "recommended", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3/entry#names_and_taxonomy" } ] }, { "name": "3.6.4.13", "type": "synonym", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3/entry#names_and_taxonomy" } ] }, { "name": "ATP-dependent RNA helicase DDX50", "type": "synonym", "evidence": [ { "id": "NP_001192982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192982" } ] }, { "name": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 50", "type": "synonym", "evidence": [ { "id": "NP_001192982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192982" } ] }, { "name": "DEAD box protein 50", "type": "synonym", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3/entry#names_and_taxonomy" } ] }, { "name": "DEAD-box helicase 50", "type": "synonym", "evidence": [ { "id": "NP_001192982", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192982" } ] }, { "name": "Gu-beta", "type": "synonym", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3/entry#names_and_taxonomy" } ] }, { "name": "Nucleolar protein Gu2", "type": "synonym", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production. Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses. For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection. Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta.", "evidence": [ { "database": "UniProtKB", "id": "F1MMK3", "url": "https://www.uniprot.org/uniprotkb/F1MMK3#function" }, { "database": "UniProtKB", "id": "ARBA00055728", "url": "https://www.uniprot.org/uniprotkb/ARBA00055728#function" }, { "database": "UniProtKB", "id": "A0ABI0NP40", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NP40#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMK3", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DDX50", "url": "https://www.uniprot.org/uniprotkb/F1MMK3", "locus": { "chromosome": "28", "start_pos": 25211518, "end_pos": 25178297, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033413", "url": "https://www.ensembl.org/id/ENSBTAG00000033413" } ] } } ], "crossref": [ { "id": "F1MMK3", "url": "https://alphafold.ebi.ac.uk/entry/F1MMK3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033413", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033413", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12936", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12936", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17944", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17944", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18787", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18787", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534331", "url": "https://www.ncbi.nlm.nih.gov/gene/534331", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR059027", "url": "https://www.ebi.ac.uk/interpro/entry/IPR059027", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534331", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534331", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EHTMQRF", "url": "https://omabrowser.org/oma/group/EHTMQRF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MFA6", "url": "https://www.orthodb.org/?gene=A0A3Q1MFA6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MMK3", "url": "https://www.orthodb.org/?gene=F1MMK3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47959", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47959", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47959:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47959:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08152", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08152", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26142", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26142", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192982", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MFA6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFA6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MFA6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFA6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NP40", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NP40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NP40-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NP40-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMK3", "url": "https://www.uniprot.org/uniprotkb/F1MMK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMK3-1", "url": "https://www.uniprot.org/uniprotkb/F1MMK3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGKLLWGDIMELEAPLEETESQRKERQKSDRRKSRHHYDSDEKSETRENGVTDDLDAPKPKKAKMKEKLNGDTEEGCDRLSDEFSKSHKPRRKDLSNGDIDEHEKRSKRVSSLNSSTHKSSDNKVEETLTREQKEGAFSNFPISEETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDVTRKLSVACFYGGTSYQSQINHIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVEDILHESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVEHLAIQCHWSQRPAVIGDVLQVYSGSEGRAIIFCETKKNVTEMAMNPHIKQNAQCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICICFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSYAAVDFFRPSAQRLIEEKGAVDALAAALAHISGASSFEPRSLITSDKGFVTMTLESPEEIQDVSCAWKELNRKLSSNAVSQITRMCLLKGNMGVCFDVPTTESERLQAEWHDSDWILSVPAKLPEIEEYYDGNTSSNSRQRSGWSSGRLGRSGRSGGRSGGRSGRQSRQGSRTGSRQDGRRRSGNRNRSRSGGHKRNFD", "length": 737, "header": "tr|F1MMK3-1|F1MMK3_BOVIN Isoform 1 of ATP-dependent RNA helicase DDX50 OS=Bos taurus OX=9913 GN=DDX50 PE=3 SV=1 CANONICAL=F1MMK3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MFA6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MFA6/entry", "sequence": { "sequence": "MPGKLLWGDIMELEAPLEETESQRKERQKSDRRKSRHHYDSDEKSETRENGVTDDLDAPKPKKAKMKEKLNGDTEEGCDRLSDEFSKSHKPRRKDLSNGDIDEHEKRSKRVSSLNSSTHKSSDNKVEETLTREQKEGAFSNFPISEETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDVTRKLSVACFYGGTSYQSQINHIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVEDILHESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVENAQCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICICFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSYAAVDFFRPSAQRLIEEKGAVDALAAALAHISGASSFEPRSLITSDKGFVTMTLESPEEIQDVSCAWKELNRKLSSNAVSQITRMCLLKGNMGVCFDVPTTESERLQAEWHDSDWILSVPAKLPEIEEYYDGNTSSNSRQRSGWSSGRLGRSGRSGGRSGGRSGRQSRQGSRTGSRQDGRRRSGNRNRSRSGGHKRNFD", "length": 687, "header": "tr|A0A3Q1MFA6-1|F1MMK3_BOVIN Computationally mapped isoform of ATP-dependent RNA helicase DDX50 OS=Bos taurus OX=9913 GN=DDX50 PE=3 SV=2 CANONICAL=F1MMK3-1" }, "locus": { "chromosome": "28", "start_pos": 25211300, "end_pos": 25178419, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077187.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077187.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000069799.2", "url": "https://www.ensembl.org/id/ENSBTAP00000069799.2" } ] } }, { "isoform_ac": "A0ABI0NP40-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NP40/entry", "sequence": { "sequence": "MKEKLNGDTEEGCDRLSDEFSKSHKPRRKDLSNGDIDEHEKRSKRVSSLNSSTHKSSDNKVEETLTREQKEGAFSNFPISEETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDVTRKLSVACFYGGTSYQSQINHIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVEDILHESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVEHLAIQCHWSQRPAVIGDVLQVYSGSEGRAIIFCETKKNVTEMAMNPHIKQNAQCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICICFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSYAAVDFFRPSAQRLIEEKGAVDALAAALAHISGASSFEPRSLITSDKGFVTMTLESPEEIQDVSCAWKELNRKLSSNAVSQITRMCLLKGNMGVCFDVPTTESERLQAEWHDSDWILSVPAKLPEIEEYYDGNTSSNSRQRSGWSSGRLGRSGRSGGRSGGRSGRQSRQGSRTGSRQDGRRRSGNRNRSRSGGHKRNFD", "length": 672, "header": "tr|A0ABI0NP40-1|A0ABI0NP40_BOVIN Computationally mapped isoform of ATP-dependent RNA helicase DDX50 OS=Bos taurus OX=9913 GN=DDX50 PE=3 SV=1 CANONICAL=F1MMK3-1" }, "locus": { "chromosome": "28", "start_pos": 25211300, "end_pos": 25182171, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145522.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145522.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000107280.1", "url": "https://www.ensembl.org/id/ENSBTAP00000107280.1" } ] } }, { "isoform_ac": "F1MMK3-1", "url": "https://www.uniprot.org/uniprotkb/F1MMK3/entry", "sequence": { "sequence": "MPGKLLWGDIMELEAPLEETESQRKERQKSDRRKSRHHYDSDEKSETRENGVTDDLDAPKPKKAKMKEKLNGDTEEGCDRLSDEFSKSHKPRRKDLSNGDIDEHEKRSKRVSSLNSSTHKSSDNKVEETLTREQKEGAFSNFPISEETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDVTRKLSVACFYGGTSYQSQINHIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVEDILHESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVEHLAIQCHWSQRPAVIGDVLQVYSGSEGRAIIFCETKKNVTEMAMNPHIKQNAQCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICICFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSYAAVDFFRPSAQRLIEEKGAVDALAAALAHISGASSFEPRSLITSDKGFVTMTLESPEEIQDVSCAWKELNRKLSSNAVSQITRMCLLKGNMGVCFDVPTTESERLQAEWHDSDWILSVPAKLPEIEEYYDGNTSSNSRQRSGWSSGRLGRSGRSGGRSGGRSGRQSRQGSRTGSRQDGRRRSGNRNRSRSGGHKRNFD", "length": 737, "header": "tr|F1MMK3-1|F1MMK3_BOVIN Isoform 1 of ATP-dependent RNA helicase DDX50 OS=Bos taurus OX=9913 GN=DDX50 PE=3 SV=1 CANONICAL=F1MMK3-1" }, "locus": { "chromosome": "28", "start_pos": 25211300, "end_pos": 25178419, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022002.5", "url": "https://www.ensembl.org/id/ENSBTAT00000022002.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022002.3", "url": "https://www.ensembl.org/id/ENSBTAP00000022002.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:534331", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534331", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZG48-1", "protein_name": "ATP-dependent RNA helicase DDX50", "gene_name": "Ddx50", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPGKLLWGDIMELEAPLEESESQRKERQKNDRRKSRHHSESEERTETRENGVTDDLDAPKPKKAKTREKLNGDTKEGLRFSDEFSPSHKSRRKDLPNGDVDEYEKRSKRVSSSENSHKSSDKADETLTREQKEGAFSNFSISEETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDITRKLNVACFYGGTSYQSQINQIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVEDIIHESYKSDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVEHLAIQCHWSQRPAVIGDVLQVYSGSEGRAIIFCETKKNVTEMAMNPHIKQNAQCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICVCFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSYAAVDFFRPSAQRLIEEKGAVDALAAALAHISGASSFEPRSLITSDKGFVTMTLESPEEIQDVSCAWKELNRKLSSNAVSQVTRMCLLKGNMGVCFDVPTSESERLQAEWHDSDWILSVPAKLPEIEEYYDGNTSSNPRQRSGWSGGRSGRSGRSGGRSGGRSGRQSRQGSRSGSRQDGRRRSGNRNRSRSGGHKRSFD", "length": 734 }, "evidence": [ { "id": "F1MMK3", "url": "https://omabrowser.org/oma/group/F1MMK3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99MJ9-1", "protein_name": "ATP-dependent RNA helicase DDX50", "gene_name": "Ddx50", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPGKLLWGDIMELEAPLEESESQRKERQKSDRRKSRHHSESEERTETRENGVTDDLDAPKPKKAKMREKLNGDTKEGLRFSDEFSPSHKSRRKDLPNGDVDEYEKRSKRVSSSENSHKSSDKAEETLTREQKEGAFSNFSISEETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDITRKLSVACFYGGTSYQSQINQIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVEDIIHESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVEHLAIQCHWSQRPAVIGDVLQVYSGSEGRAIIFCETKKNVTEMAMNPHIKQNAQCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICVCFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSYAAVDFFRPSAQRLIEEKGAVDALAAALAHISGASSFEPRSLITSDKGFVTMTLESPEEIQDVSCAWKELNRKLSSNAVSHVTRMCLLKGNMGVCFDVPTSESERLQAEWHDSDWILSVPAKLPEIEEYYDGNTSSNPRQRSGWSGGRSGRSGRSGGRSGGRSGRQSRQGSRSGSRQDGRRRSGNRNRSRSGGHKRNFD", "length": 734 }, "evidence": [ { "id": "F1MMK3", "url": "https://omabrowser.org/oma/group/F1MMK3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BQ39-1", "protein_name": "ATP-dependent RNA helicase DDX50", "gene_name": "DDX50", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPGKLLWGDIMELEAPLEESESQKKERQKSDRRKSRHHYDSDEKSETRENGVTDDLDAPKAKKSKMKEKLNGDTEEGFNRLSDEFSKSHKSRRKDLPNGDIDEYEKKSKRVSSLDTSTHKSSDNKLEETLTREQKEGAFSNFPISEETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDITRKLSVACFYGGTSYQSQINHIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVEDIIHESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVEHLAIQCHWSQRPAVIGDVLQVYSGSEGRAIIFCETKKNVTEMAMNPHIKQNAQCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICICFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSYAAVDFFRPSAQRLIEEKGAVDALAAALAHISGASSFEPRSLITSDKGFVTMTLESLEEIQDVSCAWKELNRKLSSNAVSQITRMCLLKGNMGVCFDVPTTESERLQAEWHDSDWILSVPAKLPEIEEYYDGNTSSNSRQRSGWSSGRSGRSGRSGGRSGGRSGRQSRQGSRSGSRQDGRRRSGNRNRSRSGGHKRSFD", "length": 737 }, "evidence": [ { "id": "F1MMK3", "url": "https://omabrowser.org/oma/group/F1MMK3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1MMK3", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MMK3", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "F1MMK3", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "F1MMK3", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ], "pmid": "" }, { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "F1MMK3", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1MMK3", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MMK3", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 115, "end_pos": 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"activity": "", "evidence": [ { "id": "A5PJI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PJI5" } ] } ] }, { "uniprot_ac": "A6QLE5", "gene_name": "NLRP3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A6QLE5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLE5" } ] } ] }, { "uniprot_ac": "A6QLJ0", "gene_name": "ERCC2", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A6QLJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QLJ0" } ] } ] }, { "uniprot_ac": "A6QQR4", "gene_name": "ERCC6L", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6QQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQR4" } ] } ] }, { "uniprot_ac": "A7YSY2", "gene_name": "AFG2B", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A7YSY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7YSY2" } ] } ] }, { "uniprot_ac": "A7Z019", "gene_name": "SMARCA4", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A7Z019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7Z019" } ] } ] }, { "uniprot_ac": "E1B7X9", "gene_name": "SMARCAD1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1B7X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X9" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAN8" } ] } ] }, { "uniprot_ac": "E1BAS6", "gene_name": "SETX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BAS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAS6" } ] } ] }, { "uniprot_ac": "E1BB03", "gene_name": "ZRANB3", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": 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{ "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { 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2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MZH7" } ] } ] }, { "uniprot_ac": "G3N268", "gene_name": "DHX58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3N268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N268" } ] } ] }, { "uniprot_ac": "G3X6Y8", "gene_name": "ENTPD8", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "G3X6Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X6Y8" } ] } ] }, { "uniprot_ac": "G3X757", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "G3X757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X757" } ] } ] }, { "uniprot_ac": "O18956", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "O18956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O18956" } ] }, { "ec_number": 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"activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] } ] }, { "uniprot_ac": "Q0IIK5", "gene_name": "DDX1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0IIK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0IIK5" } ] } ] }, { "uniprot_ac": "Q0V8B7", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0V8B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8B7" } ] } ] }, { "uniprot_ac": "Q0V8H6", "gene_name": "MOV10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": 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{ "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MTJ9-1", "uniprot_ac": "F1MTJ9", "uniprot_id": "F1MTJ9_BOVIN", "mass": { "chemical_mass": 83218.0, "monoisotopic_mass": 83218.0 }, "refseq": {}, "gene_names": [ { "name": "LSS", "type": "recommended", "evidence": [ { "id": "F1MTJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9" } ] } ], "protein_names": [ { "name": "Terpene cyclase/mutase family member", "type": "recommended", "evidence": [ { "id": "F1MTJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9/entry#names_and_taxonomy" } ] }, { "name": "5.4.99.-", "type": "synonym", "evidence": [ { "id": "F1MTJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LMU2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMU2#function" }, { "database": "UniProtKB", "id": "ARBA00055567", "url": "https://www.uniprot.org/uniprotkb/ARBA00055567#function" }, { "database": "UniProtKB", "id": "A0A3Q1MK38", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK38#function" }, { "database": "UniProtKB", "id": "F1MTJ9", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9#function" }, { "database": "UniProtKB", "id": "A0AAA9TKP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKP3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MTJ9", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LSS", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9", "locus": { "chromosome": "1", "start_pos": 145889102, "end_pos": 145919545, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018936", "url": "https://www.ensembl.org/id/ENSBTAG00000018936" } ] } } ], "crossref": [ { "id": "F1MTJ9", "url": "https://alphafold.ebi.ac.uk/entry/F1MTJ9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018936", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018936", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02892", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02892", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR002365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032697", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032697", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CWARQTI", "url": "https://omabrowser.org/oma/group/CWARQTI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LMU2", "url": "https://www.orthodb.org/?gene=A0A3Q1LMU2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MK38", "url": "https://www.orthodb.org/?gene=A0A3Q1MK38", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MTJ9", "url": "https://www.orthodb.org/?gene=F1MTJ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11764", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11764", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11764:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11764:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13243", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13243", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13249", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13249", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9969896", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9969896", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "14621", "url": "https://www.rhea-db.org/rhea/14621", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LMU2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMU2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMU2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MK38", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MK38-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKP3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTJ9", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTJ9-1", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTEGTCLRRRGGPYKTEPATDLSRWRLSNQVGRQTWTYSQEEDPVREQSGLEAHLLGLDTKSFFKDLPKAHTACRGALNGVTFYAALQTEDGHWAGDYGGPLFLLPGLLITCHVANIPLPAGYREEIIRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNLLHKKGGAVFIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWMPAHPSTIWCHCRQVYLPMAYCYSTRLSAEEGPLVQSLRQELYLEDYSCIDWAAHRNSVAPDDLYTPHSWLLHVVYAILNLYERHHSTSLRQWATQKLYEHIAADDRFTKCISIGPISKTINMLVRWHVDGPASAVFQEHVSRIPDYLWLGLDGMKMQGTNGSQIWDTAFAIQALLEARAQHRPEFWSCLRKAHEYLRISQVPDNFPDYQKYYRHMSKGGFSFSTLDCGWIVADCTAEALKSILLLQEKCPFVSNHVPRERLFDTVAVLLSLRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKTFHKQFPDHRAGEIRETLEQGLQFCRQKQRPDGSWEGSWGVCFTYGAWFGLEAFACMGHTYHNGVACAEISRACDFLLSRQMADGGWGEDFESCKQRRYVQSAQSQIHNTCWALMGLMAVRHPDVAALERGVSYLLEKQLPNGDWPQENISGVFNKSCAISYTSYRNVFPIWTLGRFSRLHPESALTGHP", "length": 732, "header": "tr|F1MTJ9-1|F1MTJ9_BOVIN Isoform 1 of Terpene cyclase/mutase family member OS=Bos taurus OX=9913 GN=LSS PE=3 SV=1 CANONICAL=F1MTJ9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LMU2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMU2/entry", "sequence": { "sequence": "MTEGTCLRRRGGPYKTEPATDLSRWRLSNQVGRQTWTYSQEEDPVREQSGLEAHLLGLDTKSFFKDLPKAHTACRGALNGVTFYAALQTEDGHWAGDYGGPLFLLPGLLITCHVANIPLPAGYREEIIRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNLLHKKGGAVFIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWMPAHPSTIWCHCRQVYLPMAYCYSTRLSAEEGPLVQSLRQELYLEDYSCIDWAAHRNSVAPDDLYTPHSWLLHVVYAILNLYERHHSTSLRQWATQKLYEHIAADDRFTKCISIGPISKTINMLVRWHVDGPASAVFQEHVSRIPDYLWLGLDGMKMQGTNGSQIWDTAFAIQALLEARAQHRPEFWSCLRKAHEYLRISQLLSLRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKTFHKQFPDHRAGEIRETLEQGLQFCRQKQRPDGSWEGSWGVCFTYGAWFGLEAFACMGHTYHNGVACAEISRACDFLLSRQMADGGWGEDFESCKQRRYVQSAQSQIHNTCWALMGLMAVRHPDVAALERGVSYLLEKQLPNGDWPQENISGVFNKSCAISYTSYRNVFPIWTLGRFSRLHPESALTGHP", "length": 665, "header": "tr|A0A3Q1LMU2-1|F1MTJ9_BOVIN Computationally mapped isoform of Terpene cyclase/mutase family member OS=Bos taurus OX=9913 GN=LSS PE=3 SV=1 CANONICAL=F1MTJ9-1" }, "locus": { "chromosome": "1", "start_pos": 145919492, "end_pos": 145891082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069007.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069007.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061228.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061228.1" } ] } }, { "isoform_ac": "A0A3Q1MK38-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MK38/entry", "sequence": { "sequence": "MTEGTCLRRRGGPYKTEPATDLSRWRLSNQVGRQTWTYSQEEDPVREQSGLEAHLLGLDTKSFFKDLPKAHTACRGALNGVTFYAALQTEDGHWAGDYGGPLFLLPGLLITCHVANIPLPAGYREEIIRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNLLHKKGGAVFIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWMPAHPSTIWCHCRQVYLPMAYCYSTRLSAEEGPLVQSLRQELYLEDYSCIDWAAHRNSVAPDDLYTPHSWLLHVVYAILNLYERHHSTSLRQWATQKLYEHIAADDRFTKCISIGPISKTINMLVRWHVDGPASAVFQEHVSRIPDYLWLGLDGMKMQTYAARAQHRPEFWSCLRKAHEYLRISQVPDNFPDYQKYYRHMSKGGFSFSTLDCGWIVADCTAEALKSILLLQEKCPFVSNHVPRERLFDTVAVLLSLRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKTFHKQFPDHRAGEIRETLEQGLQFCRQKQRPDGSWEGSWGVCFTYGAWFGLEAFACMGHTYHNGVACAEISRACDFLLSRQMADGGWGEDFESCKQRRYVQSAQSQIHNTCWALMGLMAVRHPDVAALERGVSYLLEKQLPNGDWPQENISGVFNKSCAISYTSYRNVFPIWTLGRFSRLHPESALTGHP", "length": 716, "header": "tr|A0A3Q1MK38-1|F1MTJ9_BOVIN Computationally mapped isoform of Terpene cyclase/mutase family member OS=Bos taurus OX=9913 GN=LSS PE=3 SV=1 CANONICAL=F1MTJ9-1" }, "locus": { "chromosome": "1", "start_pos": 145919492, "end_pos": 145891082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071806.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071806.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071197.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071197.1" } ] } }, { "isoform_ac": "A0AAA9TKP3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKP3/entry", "sequence": { "sequence": "MTEGTCLRRRGGPYKTEPATDLSRWRLSNQVGRQTWTYSQEEDPVREQSGLEAHLLGLDTKSFFKDLPKAHTACRGALNGVTFYAALQTEDGHWAGDYGGPLFLLPGLLITCHVANIPLPAGYREEIIRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNLLHKKGGAVFIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWMPAHPSTIWCHCRQVYLPMAYCYSTRLSAEEGPLVQSLRQELYLEDYSCIDWAAHRNSVAPDDLYTPHSWLLHVVYAILNLYERHHSTSLRQWATQKLYEHIAADDRFTKCISIGPISKTINMLVRWHVDGPASAVFQEHVSRIPDYLWLGLDGMKMQGTNGSQIWDTAFAIQALLEARAQHRPEFWSCLRKAHEYLRISQGGFSFSTLDCGWIVADCTAEALKSILLLQEKCPFVSNHVPRERLFDTVAVLLSLRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKTFHKQFPDHRAGEIRETLEQGLQFCRQKQRPDGSWEGSWGVCFTYGAWFGLEAFACMGHTYHNGVACAEISRACDFLLSRQMADGGWGEDFESCKQRRYVQSAQSQIHNTCWALMGLMAVRHPDVAALERGVSYLLEKQLPNGDWPQENISGVFNKSCAISYTSYRNVFPIWTLGRFSRLHPESALTGHP", "length": 715, "header": "tr|A0AAA9TKP3-1|F1MTJ9_BOVIN Computationally mapped isoform of Terpene cyclase/mutase family member OS=Bos taurus OX=9913 GN=LSS PE=3 SV=1 CANONICAL=F1MTJ9-1" }, "locus": { "chromosome": "1", "start_pos": 145919492, "end_pos": 145891082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111185.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111185.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098965.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098965.1" } ] } }, { "isoform_ac": "F1MTJ9-1", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9/entry", "sequence": { "sequence": "MTEGTCLRRRGGPYKTEPATDLSRWRLSNQVGRQTWTYSQEEDPVREQSGLEAHLLGLDTKSFFKDLPKAHTACRGALNGVTFYAALQTEDGHWAGDYGGPLFLLPGLLITCHVANIPLPAGYREEIIRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNLLHKKGGAVFIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWMPAHPSTIWCHCRQVYLPMAYCYSTRLSAEEGPLVQSLRQELYLEDYSCIDWAAHRNSVAPDDLYTPHSWLLHVVYAILNLYERHHSTSLRQWATQKLYEHIAADDRFTKCISIGPISKTINMLVRWHVDGPASAVFQEHVSRIPDYLWLGLDGMKMQGTNGSQIWDTAFAIQALLEARAQHRPEFWSCLRKAHEYLRISQVPDNFPDYQKYYRHMSKGGFSFSTLDCGWIVADCTAEALKSILLLQEKCPFVSNHVPRERLFDTVAVLLSLRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKTFHKQFPDHRAGEIRETLEQGLQFCRQKQRPDGSWEGSWGVCFTYGAWFGLEAFACMGHTYHNGVACAEISRACDFLLSRQMADGGWGEDFESCKQRRYVQSAQSQIHNTCWALMGLMAVRHPDVAALERGVSYLLEKQLPNGDWPQENISGVFNKSCAISYTSYRNVFPIWTLGRFSRLHPESALTGHP", "length": 732, "header": "tr|F1MTJ9-1|F1MTJ9_BOVIN Isoform 1 of Terpene cyclase/mutase family member OS=Bos taurus OX=9913 GN=LSS PE=3 SV=1 CANONICAL=F1MTJ9-1" }, "locus": { "chromosome": "1", "start_pos": 145919492, "end_pos": 145891082, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025201.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025201.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025201.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025201.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-9969896", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9969896", "resource": "Reactome", "description": "Lanosterol biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "G3H8Y0-1", "protein_name": "Terpene cyclase/mutase family member", "gene_name": "Lss", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTEGTCLRRRRGGPYKTEPATDLTRWRLRNELGRQRWTYFQAEDDPGREQTGLEAHSLGLDTKNYFKDLPKAKTVHEAALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHVSHIPLPAGYREEMVRYLRSVQLPDGGWGLHVEDKSTVFGTALNYVALRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWFPAHPSTLWCHCRQVYLPMSYCYATRLSAPEDPLVQSLRQELYVEDYASINWPAQKNNVSPDELYTPHSWLLHVVYGLLNLYERFHSTSLRQRAIKMLYEHIVADDRFTKSISIGPISKTINMLVRWSVDGPSSSAFQEHVSRIPDYIWLGLDGMKMQGTNGSQVWDTAFAIQALLEAGAHHRPEFLPCLQKAHEFLRLSQVPDNFPDYQKYYRQMHKGGFPFSTLDCGWIVADCTAEGLKSVLLLQKQCPSIREHVPRERLCDAVDVLLSMRNSDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKHFHEHYPDHRAAEIRETLKQGLEFCRKQQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGSARAEVSQACNFLLSQQMADGGWGEDFESCEQRRYVQSAKSQVHNTCWALMGLMAVRHPDITAQERGIRCLLEKQLSNGDWPQENISGVFNKSCAISYTSYRNIFPIWALGRFSNLYPDNSLAGHL", "length": 734 }, "evidence": [ { "id": "F1MTJ9", "url": "https://omabrowser.org/oma/group/F1MTJ9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P38604-1", "protein_name": "Lanosterol synthase ERG7", "gene_name": "ERG7", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTEFYSDTIGLPKTDPRLWRLRTDELGRESWEYLTPQQAANDPPSTFTQWLLQDPKFPQPHPERNKHSPDFSAFDACHNGASFFKLLQEPDSGIFPCQYKGPMFMTIGYVAVNYIAGIEIPEHERIELIRYIVNTAHPVDGGWGLHSVDKSTVFGTVLNYVILRLLGLPKDHPVCAKARSTLLRLGGAIGSPHWGKIWLSALNLYKWEGVNPAPPETWLLPYSLPMHPGRWWVHTRGVYIPVSYLSLVKFSCPMTPLLEELRNEIYTKPFDKINFSKNRNTVCGVDLYYPHSTTLNIANSLVVFYEKYLRNRFIYSLSKKKVYDLIKTELQNTDSLCIAPVNQAFCALVTLIEEGVDSEAFQRLQYRFKDALFHGPQGMTIMGTNGVQTWDCAFAIQYFFVAGLAERPEFYNTIVSAYKFLCHAQFDTECVPGSYRDKRKGAWGFSTKTQGYTVADCTAEAIKAIIMVKNSPVFSEVHHMISSERLFEGIDVLLNLQNIGSFEYGSFATYEKIKAPLAMETLNPAEVFGNIMVEYPYVECTDSSVLGLTYFHKYFDYRKEEIRTRIRIAIEFIKKSQLPDGSWYGSWGICFTYAGMFALEALHTVGETYENSSTVRKGCDFLVSKQMKDGGWGESMKSSELHSYVDSEKSLVVQTAWALIALLFAEYPNKEVIDRGIDLLKNRQEESGEWKFESVEGVFNHSCAIEYPSYRFLFPIKALGMYSRAYETHTL", "length": 731 }, "evidence": [ { "id": "F1MTJ9", "url": "https://omabrowser.org/oma/group/F1MTJ9/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P38605-1", "protein_name": "Cycloartenol synthase", "gene_name": "CAS1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MWKLKIAEGGSPWLRTTNNHVGRQFWEFDPNLGTPEDLAAVEEARKSFSDNRFVQKHSADLLMRLQFSRENLISPVLPQVKIEDTDDVTEEMVETTLKRGLDFYSTIQAHDGHWPGDYGGPMFLLPGLIITLSITGALNTVLSEQHKQEMRRYLYNHQNEDGGWGLHIEGPSTMFGSVLNYVTLRLLGEGPNDGDGDMEKGRDWILNHGGATNITSWGKMWLSVLGAFEWSGNNPLPPEIWLLPYFLPIHPGRMWCHCRMVYLPMSYLYGKRFVGPITSTVLSLRKELFTVPYHEVNWNEARNLCAKEDLYYPHPLVQDILWASLHKIVEPVLMRWPGANLREKAIRTAIEHIHYEDENTRYICIGPVNKVLNMLCCWVEDPNSEAFKLHLPRIHDFLWLAEDGMKMQGYNGSQLWDTGFAIQAILATNLVEEYGPVLEKAHSFVKNSQVLEDCPGDLNYWYRHISKGAWPFSTADHGWPISDCTAEGLKAALLLSKVPKAIVGEPIDAKRLYEAVNVIISLQNADGGLATYELTRSYPWLELINPAETFGDIVIDYPYVECTSAAIQALISFRKLYPGHRKKEVDECIEKAVKFIESIQAADGSWYGSWAVCFTYGTWFGVKGLVAVGKTLKNSPHVAKACEFLLSKQQPSGGWGESYLSCQDKVYSNLDGNRSHVVNTAWAMLALIGAGQAEVDRKPLHRAARYLINAQMENGDFPQQEIMGVFNRNCMITYAAYRNIFPIWALGEYRCQVLLQQGE", "length": 759 }, "evidence": [ { "id": "F1MTJ9", "url": "https://omabrowser.org/oma/group/F1MTJ9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "P48449-1", "protein_name": "Lanosterol synthase", "gene_name": "LSS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDTKNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFSQLYPERALAGHP", "length": 732 }, "evidence": [ { "id": "F1MTJ9", "url": "https://omabrowser.org/oma/group/F1MTJ9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P48450-1", "protein_name": "Lanosterol synthase", "gene_name": "Lss", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTEGTCLRRRGGPYKTEPATDLTRWRLHNELGRQRWTYYQAEEDPGREQTGLEAHSLGLDTTSYFKNLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALSYVSLRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQALLEAGAHRRPEFLPCLQKAHEFLRLSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQERCPSITEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALRHFREYFPDHRATESRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNRTACAEVAQACHFLLSRQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWALGRFSSLYPDNTLAGHI", "length": 733 }, "evidence": [ { "id": "F1MTJ9", "url": "https://omabrowser.org/oma/group/F1MTJ9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q55D85-1", "protein_name": "Cycloartenol synthase", "gene_name": "cas1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTTTNWSLKVDRGRQTWEYSQEKKEATDVDIHLLRLKEPGTHCPEGCDLNRAKTPQQAIKKAFQYFSKVQTEDGHWAGDYGGPMFLLPGLVITCYVTGYQLPESTQREIIRYLFNRQNPVDGGWGLHIEAHSDIFGTTLQYVSLRLLGVPADHPSVVKARTFLLQNGGATGIPSWGKFWLATLNAYDWNGLNPIPIEFWLLPYNLPIAPGRWWCHCRMVYLPMSYIYAKKTTGPLTDLVKDLRREIYCQEYEKINWSEQRNNISKLDMYYEHTSLLNVINGSLNAYEKVHSKWLRDKAIDYTFDHIRYEDEQTKYIDIGPVNKTVNMLCVWDREGKSPAFYKHADRLKDYLWLSFDGMKMQGYNGSQLWDTAFTIQAFMESGIANQFQDCMKLAGHYLDISQVPEDARDMKHYHRHYSKGAWPFSTVDHGWPISDCTAEGIKSALALRSLPFIEPISLDRIADGINVLLTLQNGDGGWASYENTRGPKWLEKFNPSEVFQNIMIDYSYVECSAACIQAMSAFRKHAPNHPRIKEINRSIARGVKFIKSIQRQDGSWLGSWGICFTYGTWFGIEGLVASGEPLTSPSIVKACKFLASKQRADGGWGESFKSNVTKEYVQHETSQVVNTGWALLSLMSAKYPDRECIERGIKFLIQRQYPNGDFPQESIIGVFNFNCMISYSNYKNIFPLWALSRYNQLYLKSKI", "length": 703 }, "evidence": [ { "id": "F1MTJ9", "url": "https://omabrowser.org/oma/group/F1MTJ9/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8BLN5-1", "protein_name": "Lanosterol synthase", "gene_name": "Lss", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTEGTCLRRRGGPYKTEPATDLTRWRLQNELGRQRWTYYQAEDDPGREQTGLEAHSLGLDTRSYFTDLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHISHISLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVALRILGIGPDDPDLVRARNVLHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPEWVPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVQDYASIDWPAQRNNVSPDEMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAVQMLYEHIAADDCFTKCISIGPISKTINMLVRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQIWDTSFAIQALLEAGAHHRPEFLPCLQKAHEFLRLSQVPENCPDYQKYYRHMRKGGFSFSTLDCGWIVADCTAEGLKAVLLLQNQCPSITEHIPRERLCDAVDVLLSLRNADGGFATYEKKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALKHFHEHFPDYRAAEVRETLNQGLDFCRRKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHTYQDGAACAEVAQACNFLLSQQMADGGWGEDFESCEQRRYVQSARSQVHSTCWALMGLMAVRHPDITAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTSYRNIFPIWALGRFSNLYPDNTLAGHI", "length": 733 }, "evidence": [ { "id": "F1MTJ9", "url": "https://omabrowser.org/oma/group/F1MTJ9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "F1MTJ9", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9" } ], "pmid": "" }, { "name": "cytoplasmic side of endoplasmic reticulum membrane", "id": "GO:0098554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098554", "evidence": [ { "database": "UniProtKB", "id": "F1MTJ9", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "cholesterol biosynthetic process", "id": "GO:0006695", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006695", "evidence": [ { "database": "UniProtKB", "id": "F1MTJ9", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9" } ], "pmid": "" }, { "name": "triterpenoid biosynthetic process", "id": "GO:0016104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016104", "evidence": [ { "database": "UniProtKB", "id": "F1MTJ9", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9" } ], "pmid": "" }, { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "F1MTJ9", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9" } ], "pmid": "" }, { "name": "cholesterol biosynthetic process via desmosterol", "id": "GO:0033489", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033489", "evidence": [ { "database": "UniProtKB", "id": "F1MTJ9", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9" } ], "pmid": "" }, { "name": "cholesterol biosynthetic process via lathosterol", "id": "GO:0033490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033490", "evidence": [ { "database": "UniProtKB", "id": "F1MTJ9", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9" } ], "pmid": "" }, { "name": "zymosterol biosynthetic process", "id": "GO:0036197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036197", "evidence": [ { "database": "UniProtKB", "id": "F1MTJ9", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "lanosterol synthase activity", "id": "GO:0000250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000250", "evidence": [ { "database": "UniProtKB", "id": "F1MTJ9", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 382, "end_pos": 384, "annotation": "n_glycosylation_sequon" }, { "start_pos": 691, "end_pos": 693, "annotation": "n_glycosylation_sequon" }, { "start_pos": 697, "end_pos": 699, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "14621", "name": "", "equation": "(S)-2,3-epoxysqualene = lanosterol", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P84466-1", "F1MTJ9-1" ], "evidence": [ { "id": "14621", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14621" } ] }, { "id": "R-BTA-191366", "name": "Squalene 2,3-epoxide cyclizes, forming lanosterol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-191309" ], "output_participant_list": [], "enzyme_list": [ "F1MTJ9-1" ], "evidence": [ { "id": "R-BTA-191366", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191366" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-191309", "participant_name": "SQOX [cytosol]", "crossref": [ { "id": "15441", "database": "ChEBI", "url": "" }, { "id": "C01054", "database": "COMPOUND", "url": "" }, { "id": "6551", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "ZINC000004095521", "database": "ZINC", "url": "" }, { "id": "HMDB0001188", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "F1MTJ9", "gene_name": "LSS", "activity": [ { "ec_number": "5.4.99.-", "activity": "", "evidence": [ { "id": "F1MTJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9" } ] } ] }, { "uniprot_ac": "P84466", "gene_name": "LSS", "activity": [ { "ec_number": "5.4.99.7", "activity": "(S)-2,3-epoxysqualene = lanosterol.", "evidence": [ { "id": "P84466", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84466" } ] }, { "ec_number": "5.4.99.7", "activity": "", "evidence": [ { "id": "P84466", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P84466" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MTJ9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 732, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MTJ9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MTJ9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MTJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9" }, { "id": "PF13243", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13243" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Squalene cyclase C-terminal", "eco_id": "ECO_0000259", "start_pos": 384, "end_pos": 720, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MTJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTJ9" }, { "id": "PF13249", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13249" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Squalene cyclase N-terminal", "eco_id": "ECO_0000259", "start_pos": 85, "end_pos": 326, "start_aa": "Ala", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 382, "end_pos": 384 }, { "start_pos": 691, "end_pos": 693 }, { "start_pos": 697, "end_pos": 699 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMH3-1", "uniprot_ac": "F1MMH3", "uniprot_id": "F1MMH3_BOVIN", "mass": { "chemical_mass": 43719.0, "monoisotopic_mass": 43719.0 }, "refseq": {}, "gene_names": [ { "name": "LUC7L", "type": "recommended", "evidence": [ { "id": "F1MMH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMH3" } ] } ], "protein_names": [ { "name": "LUC7 like", "type": "synonym", "evidence": [ { "id": "F1MMH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMH3/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Binds cAMP regulatory element DNA sequence. Plays a role in RNA splicing.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MTQ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTQ0#function" }, { "database": "UniProtKB", "id": "RU369106", "url": "https://www.uniprot.org/uniprotkb/RU369106#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMH3", "url": "https://www.uniprot.org/uniprotkb/F1MMH3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LUC7L", "url": "https://www.uniprot.org/uniprotkb/F1MMH3", "locus": { "chromosome": "25", "start_pos": 230276, "end_pos": 263921, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016568", "url": "https://www.ensembl.org/id/ENSBTAG00000016568" } ] } } ], "crossref": [ { "id": "F1MMH3", "url": "https://alphafold.ebi.ac.uk/entry/F1MMH3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016568", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016568", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "535131", "url": "https://www.ncbi.nlm.nih.gov/gene/535131", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR004882", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004882", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CPYDLFQ", "url": "https://omabrowser.org/oma/group/CPYDLFQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MTQ0", "url": "https://www.orthodb.org/?gene=A0A3Q1MTQ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MMH3", "url": "https://www.orthodb.org/?gene=F1MMH3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12375", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12375", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03194", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03194", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MTQ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MTQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMH3", "url": "https://www.uniprot.org/uniprotkb/F1MMH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMH3-1", "url": "https://www.uniprot.org/uniprotkb/F1MMH3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAQAQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERLSRRSGSRTRDRRRSRSRDRRRRRSRSTSRERRKSSRSRSRDRHRRHRSRSRSHSRGHRRASRDRSSKYKFSRERTSREESWERGRSERGATDWRLESANGKAASRRSEEKEAGEI", "length": 371, "header": "tr|F1MMH3-1|F1MMH3_BOVIN Isoform 1 of LUC7 like OS=Bos taurus OX=9913 GN=LUC7L PE=3 SV=1 CANONICAL=F1MMH3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MTQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MTQ0/entry", "sequence": { "sequence": "MIFTGSRLARKHGIYFPVWDCLNLFPFIAFSSRWSLEVLGSRVKSRRELAPPPEQFACVICATERQARLQTTFPSRPWAGADALPPGVPRVEKEPSGLETDRSSFRRRHRRCRRRRRCRHLREAVAATPAAPAGHHVRPGADAGPAGPAHGHGPGRFSVSLPAYINLQGSCRKASCSSSRDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERLSRRSGSRTRDRRRSRSRDRRRRRSRSTSRERRKSSRSRSRDRHRRHRSRSRSHSRGHRRASRDRSSKYKFSRERTSREESWERGRSERGATDWRLESANGKAASRRSEEKEAGEI", "length": 530, "header": "tr|A0A3Q1MTQ0-1|F1MMH3_BOVIN Computationally mapped isoform of LUC7 like OS=Bos taurus OX=9913 GN=LUC7L PE=3 SV=1 CANONICAL=F1MMH3-1" }, "locus": { "chromosome": "25", "start_pos": 263722, "end_pos": 231280, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075438.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075438.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058074.1", "url": "https://www.ensembl.org/id/ENSBTAP00000058074.1" } ] } }, { "isoform_ac": "F1MMH3-1", "url": "https://www.uniprot.org/uniprotkb/F1MMH3/entry", "sequence": { "sequence": "MSAQAQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERLSRRSGSRTRDRRRSRSRDRRRRRSRSTSRERRKSSRSRSRDRHRRHRSRSRSHSRGHRRASRDRSSKYKFSRERTSREESWERGRSERGATDWRLESANGKAASRRSEEKEAGEI", "length": 371, "header": "tr|F1MMH3-1|F1MMH3_BOVIN Isoform 1 of LUC7 like OS=Bos taurus OX=9913 GN=LUC7L PE=3 SV=1 CANONICAL=F1MMH3-1" }, "locus": { "chromosome": "25", "start_pos": 263316, "end_pos": 231280, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022041.5", "url": "https://www.ensembl.org/id/ENSBTAT00000022041.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022041.3", "url": "https://www.ensembl.org/id/ENSBTAP00000022041.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z0F5-1", "protein_name": "LUC7 like", "gene_name": "LUC7L", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSAQAQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEDIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERMGRRSGSRNRDRRRSRSRDRRRRRSRSASRERRKSRSRSRDRHRRHRSRSRSHSRGHRRGSRDRSSKHKSSRDRSSREKSRDRERKEKSSSERRHESTNGKSRSKRSEEREAGEI", "length": 370 }, "evidence": [ { "id": "F1MMH3", "url": "https://omabrowser.org/oma/group/F1MMH3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3V9R0-1", "protein_name": "LUC7-like", "gene_name": "Luc7l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAQAQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRSKKKEAEEEYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERLGRRSGSRTRDRRRSRSRDRRRRRSRSTSRERRKFSRSRSRDRYRRHRSRSRSHSRGHRRASRDRSTKYKFSRERSLREESWEYRRNERGPTDWRLENSNGKTASRREHHDCFLSLSE", "length": 373 }, "evidence": [ { "id": "F1MMH3", "url": "https://omabrowser.org/oma/group/F1MMH3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q07508-1", "protein_name": "Protein LUC7", "gene_name": "LUC7", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSTMSTPAAEQRKLVEQLMGRDFSFRHNRYSHQKRDLGLHDPKICKSYLVGECPYDLFQGTKQSLGKCPQMHLTKHKIQYEREVKQGKTFPEFEREYLAILSRFVNECNGQISVALQNLKHTAEERMKIQQVTEELDVLDVRIGLMGQEIDSLIRADEVSMGMLQSVKLQELISKRKEVAKRVRNITENVGQSAQQKLQVCEVCGAYLSRLDTDRRLADHFLGKIHLGYVKMREDYDRLMKNNRTTNASKTATTLPGRRFV", "length": 261 }, "evidence": [ { "id": "F1MMH3", "url": "https://omabrowser.org/oma/group/F1MMH3/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q9CYI4-1", "protein_name": "Putative RNA-binding protein Luc7-like 1", "gene_name": "Luc7l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAQAQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERLGRRSGSRTRDRRRSRSRDRRRRRSRSTSRERRKFSRSRSRDRYRRHRSRSRSHSRGHRRASRDRSTKYKFSRERSLREESWEYGRNERGPTDWRLENSNGKTASRRSEEKEAGEI", "length": 371 }, "evidence": [ { "id": "F1MMH3", "url": "https://omabrowser.org/oma/group/F1MMH3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NQ29-1", "protein_name": "Putative RNA-binding protein Luc7-like 1", "gene_name": "LUC7L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAQAQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERLSRRSGSRTRDRRRSRSRDRRRRRSRSTSRERRKLSRSRSRDRHRRHRSRSRSHSRGHRRASRDRSAKYKFSRERASREESWESGRSERGPPDWRLESSNGKMASRRSEEKEAGEI", "length": 371 }, "evidence": [ { "id": "F1MMH3", "url": "https://omabrowser.org/oma/group/F1MMH3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "U1 snRNP", "id": "GO:0005685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005685", "evidence": [ { "database": "UniProtKB", "id": "F1MMH3", "url": "https://www.uniprot.org/uniprotkb/F1MMH3" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1MMH3", "url": "https://www.uniprot.org/uniprotkb/F1MMH3" } ], "pmid": "" }, { "name": "U2-type prespliceosome", "id": "GO:0071004", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071004", "evidence": [ { "database": "UniProtKB", "id": "F1MMH3", "url": "https://www.uniprot.org/uniprotkb/F1MMH3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "F1MMH3", "url": "https://www.uniprot.org/uniprotkb/F1MMH3" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1MMH3", "url": "https://www.uniprot.org/uniprotkb/F1MMH3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "mRNA splice site recognition", "id": "GO:0006376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006376", "evidence": [ { "database": "UniProtKB", "id": "F1MMH3", "url": "https://www.uniprot.org/uniprotkb/F1MMH3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MMH3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 371, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MMH3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MMH3" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJM4-1", "uniprot_ac": "F1MJM4", "uniprot_id": "F1MJM4_BOVIN", "mass": { "chemical_mass": 58310.0, "monoisotopic_mass": 58310.0 }, "refseq": {}, "gene_names": [ { "name": "BTD", "type": "recommended", "evidence": [ { "id": "F1MJM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJM4" } ] } ], "protein_names": [ { "name": "Biotinidase", "type": "recommended", "evidence": [ { "id": "F1MJM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJM4/entry#names_and_taxonomy" } ] }, { "name": "3.5.1.12", "type": "synonym", "evidence": [ { "id": "F1MJM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJM4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9S203", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S203#function" }, { "database": "UniProtKB", "id": "ARBA00037073", "url": "https://www.uniprot.org/uniprotkb/ARBA00037073#function" }, { "database": "UniProtKB", "id": "A0AAA9T1P9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1P9#function" }, { "database": "UniProtKB", "id": "A0A3Q1MUX4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUX4#function" }, { "database": "UniProtKB", "id": "F1MJM4", "url": "https://www.uniprot.org/uniprotkb/F1MJM4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJM4", "url": "https://www.uniprot.org/uniprotkb/F1MJM4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BTD", "url": "https://www.uniprot.org/uniprotkb/F1MJM4", "locus": { "chromosome": "1", "start_pos": 152679233, "end_pos": 152637811, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019129", "url": "https://www.ensembl.org/id/ENSBTAG00000019129" } ] } } ], "crossref": [ { "id": "F1MJM4", "url": "https://alphafold.ebi.ac.uk/entry/F1MJM4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019129", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019129", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07567", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07567", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537669", "url": "https://www.ncbi.nlm.nih.gov/gene/537669", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012101", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012101", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036526", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036526", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040154", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040154", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SGKWNPC", "url": "https://omabrowser.org/oma/group/SGKWNPC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MUX4", "url": "https://www.orthodb.org/?gene=A0A3Q1MUX4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MJM4", "url": "https://www.orthodb.org/?gene=F1MJM4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10609", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10609", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10609:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10609:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00795", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00795", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-196780", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196780", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "77171", "url": "https://www.rhea-db.org/rhea/77171", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1MUX4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MUX4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUX4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S203", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S203", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S203-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S203-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1P9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1P9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T1P9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1P9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJM4", "url": "https://www.uniprot.org/uniprotkb/F1MJM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJM4-1", "url": "https://www.uniprot.org/uniprotkb/F1MJM4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRAGRQLALLLCSCCVAVAIPGGLAEEGCPAEPHQASRYVAAVYEHQSFLSPDPLALTSREQALELMHRNLDVYEQQVTTAARKGAQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPRSVRWNPCLEPHRFNDTEVLQRLSCMAMKGEMFLVANLGTKQPCHSSDPGCPSDGRYQFNTNVVFSSNGTLVDRYRKHNLYFEAAFDTPLEVDHTVFDTPFAGKFGVFTCFDILFFDPAVRLLQDSEVKHVVYPTAWMNQLPLLAAIQIQRGFAIAFGINLLAANIHHPSLGMTGSGIHTPLKSFWHHSMDSPEGHLIIAEVARNPPGLISAGNATGKTDPFHRKFLQLLAGDPYSEKDAQDVHCDAAPKSTTNASPTFNSEMMYDNFTLVPVWGRDGHVHVCAHGLCCHLLYQRPTVSQELYALGVFDGLHTVHGTYYVQVCALVKCGGLGFDTCGQEITEAMGMFEFHLWGNFSTSYIFPMLLTSGMMLETPDQLGWESDQYFLKKRGLSSGLVTAALYGRLYERD", "length": 525, "header": "tr|F1MJM4-1|F1MJM4_BOVIN Isoform 1 of Biotinidase OS=Bos taurus OX=9913 GN=BTD PE=3 SV=2 CANONICAL=F1MJM4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MUX4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUX4/entry", "sequence": { "sequence": "MYLMPTSCAARAISVTGMPTMPNILTSGAMSRAGRQLALLLCSCCVAVAIPGGLAEEGCPAEPHQASRYVAAVYEHQSFLSPDPLALTSREQALELMHRNLDVYEQQVTTAARKGAQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPRSVRWNPCLEPHRFNDTEVLQRLSCMAMKGEMFLVANLGTKQPCHSSDPGCPSDGRYQFNTNVVFSSNGTLVDRYRKHNLYFEAAFDTPLEVDHTVFDTPFAGKFGVFTCFDILFFDPAVRLLQDSEVKHVVYPTAWMNQLPLLAAIQIQRGFAIAFGINLLAANIHHPSLGMTGSGIHTPLKSFWHHSMDSPEGHLIIAEVARNPPGLISAGNATGKTDPFHRKFLQLLAGDPYSEKDAQDVHCDAAPKSTTNASPTFNSEMMYDNFTLVPVWGRDGHVHVCAHGLCCHLLYQRPTVSQELYALGVFDGLHTVHGTYYVQVCALVKCGGLGFDTCGQEITEAMGMFEFHLWGNFSTSYIFPMLLTSGMMLETPDQLGWESDQYFLKKRGLSSGLVTAALYGRLYERD", "length": 554, "header": "tr|A0A3Q1MUX4-1|F1MJM4_BOVIN Computationally mapped isoform of Biotinidase OS=Bos taurus OX=9913 GN=BTD PE=3 SV=2 CANONICAL=F1MJM4-1" }, "locus": { "chromosome": "1", "start_pos": 152678939, "end_pos": 152637868, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071679.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071679.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058687.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058687.2" } ] } }, { "isoform_ac": "A0AAA9S203-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S203/entry", "sequence": { "sequence": "MQTLLTSGAMSRAGRQLALLLCSCCVAVAIPGGLAEEGCPAEPHQASRYVAAVYEHQSFLSPDPLALTSREQALELMHRNLDVYEQQVTTAARKGAQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPRSVRWNPCLEPHRFNDTEVLQRLSCMAMKGEMFLVANLGTKQPCHSSDPGCPSDGRYQFNTNVVFSSNGTLVDRYRKHNLYFEAAFDTPLEVDHTVFDTPFAGKFGVFTCFDILFFDPAVRLLQDSEVKHVVYPTAWMNQLPLLAAIQIQRGFAIAFGINLLAANIHHPSLGMTGSGIHTPLKSFWHHSMDSPEGHLIIAEVARNPPGLISAGNATGKTDPFHRKFLQLLAGDPYSEKDAQDVHCDAAPKSTTNASPTFNSEMMYDNFTLVPVWGRDGHVHVCAHGLCCHLLYQRPTVSQELYALGVFDGLHTVHGTYYVQVCALVKCGGLGFDTCGQEITEAMGMFEFHLWGNFSTSYIFPMLLTSGMMLETPDQLGWESDQYFLKKRGLSSGLVTAALYGRLYERD", "length": 534, "header": "tr|A0AAA9S203-1|F1MJM4_BOVIN Computationally mapped isoform of Biotinidase OS=Bos taurus OX=9913 GN=BTD PE=3 SV=1 CANONICAL=F1MJM4-1" }, "locus": { "chromosome": "1", "start_pos": 152678939, "end_pos": 152641500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118574.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118574.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079921.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079921.1" } ] } }, { "isoform_ac": "A0AAA9T1P9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T1P9/entry", "sequence": { "sequence": "MSRAGRQLALLLCSCCVAVAIPGGLAEEGCPAEPHQASRYVAAVYEHQSFLSPDPLALTSREQALELMHRNLDVYEQQVTTAARKGAQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPRSVRWNPCLEPHRFNDTEVSLASLLSGQEAHGAGPGQGPGARTC", "length": 161, "header": "tr|A0AAA9T1P9-1|F1MJM4_BOVIN Computationally mapped isoform of Biotinidase OS=Bos taurus OX=9913 GN=BTD PE=3 SV=1 CANONICAL=F1MJM4-1" }, "locus": { "chromosome": "1", "start_pos": 152666848, "end_pos": 152661059, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134684.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134684.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090331.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090331.1" } ] } }, { "isoform_ac": "F1MJM4-1", "url": "https://www.uniprot.org/uniprotkb/F1MJM4/entry", "sequence": { "sequence": "MSRAGRQLALLLCSCCVAVAIPGGLAEEGCPAEPHQASRYVAAVYEHQSFLSPDPLALTSREQALELMHRNLDVYEQQVTTAARKGAQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPRSVRWNPCLEPHRFNDTEVLQRLSCMAMKGEMFLVANLGTKQPCHSSDPGCPSDGRYQFNTNVVFSSNGTLVDRYRKHNLYFEAAFDTPLEVDHTVFDTPFAGKFGVFTCFDILFFDPAVRLLQDSEVKHVVYPTAWMNQLPLLAAIQIQRGFAIAFGINLLAANIHHPSLGMTGSGIHTPLKSFWHHSMDSPEGHLIIAEVARNPPGLISAGNATGKTDPFHRKFLQLLAGDPYSEKDAQDVHCDAAPKSTTNASPTFNSEMMYDNFTLVPVWGRDGHVHVCAHGLCCHLLYQRPTVSQELYALGVFDGLHTVHGTYYVQVCALVKCGGLGFDTCGQEITEAMGMFEFHLWGNFSTSYIFPMLLTSGMMLETPDQLGWESDQYFLKKRGLSSGLVTAALYGRLYERD", "length": 525, "header": "tr|F1MJM4-1|F1MJM4_BOVIN Isoform 1 of Biotinidase OS=Bos taurus OX=9913 GN=BTD PE=3 SV=2 CANONICAL=F1MJM4-1" }, "locus": { "chromosome": "1", "start_pos": 152678939, "end_pos": 152661059, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025464.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025464.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025464.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025464.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-196780", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-196780", "resource": "Reactome", "description": "Biotin transport and metabolism" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MNM2-1", "protein_name": "Biotinidase", "gene_name": "Btd", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MNRRSRPTPSRFMVCIMSGACTAPALFLLLGCSALALGVGSGSPEHRDAEYYVAAVYEHRSVLSPNPLELSSRQKALELMKQNLDVYEQQVMAAAQKGVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPSLVKWNPCLEPFRFNDTEVLQRLSCMAMKGQMFLVANLGTKQPCLRSDPECPHDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDTPANVDLITFDTPFAGKFGMFTCFDILFFDPTIRLLRDSEVKHIVYPTAWMNQLPLLAAIEIQKALATAFGVSVLAANIHHPTLGMTGSGIHTPLQSFWYHDMDNPDGHLIIAQVATNPQGLVGKENATSEMDPSHSKFLKIVSGDPYCEKDAQEVHCDEAAKWNMNAPPTFHSEMMYDNFTLVPVWGKEGYLQVCSNSLCCHLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVKCGGLGFDTCGQEITEAQGLFDFHLWGNFSTSFIFPLFLTSGMTLDTPNQLGWENDHYFLRKSGLSSGLVTAALYGRLYERD", "length": 537 }, "evidence": [ { "id": "F1MJM4", "url": "https://omabrowser.org/oma/group/F1MJM4/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E1C3J7-1", "protein_name": "Biotinidase", "gene_name": "BTD", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAYDMVDLCWKLSVCFFCYQVVSGRVKKEARYVAAVYEHESILSPNPTALIDRQSALELMGRNLDIYDQQVAAAARQGAQIIVFPEDGIHGFNFTRRSIYPYLDFVPHSSSVKWNPCREKYLFNDTEVLQRLSCMALKNKIFLVANLGTKQPCKHTDPHCPRDGRYQFNTNVVFNDAGTLIATYRKHNLYFEYAFDTPTEPDYKLFDTPFAGKFGMFTCFDILFFEPAVNLIRQYNVKQIVYPTAWMNQLPLLSAVEFQQAFATAFSVNILAANIHHPTLGMTGSGIYTPVKSFIYHNMESYGGKLIVAEIPVMSTDYKTDLEHNERFRENVRRSCNTFTSTSEDDQVCFMEGQEAPGKVSEKGTEQSPPLFYAEMMYDNFTFVPVWAEKGELQVCANTLCCYLNYKRDVLTDELYALGVFDGLHTVNGIYYVQACALVKCGGLSFSTCGQEVTDATAVIDFQLWGNMSTPYIFPLLLTSGITLDFADHMGWKNNHYFLSKNRTSNGLLTAALYGRWYEKD", "length": 521 }, "evidence": [ { "id": "F1MJM4", "url": "https://omabrowser.org/oma/group/F1MJM4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RS82-1", "protein_name": "Biotinidase", "gene_name": "BTD", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSGASRQLALFLCVCSVAALGVQAEDAQYVAAVYEHRSILSLDPLSLISRTQALELMNQNLDIYEQQVMIAAQKGVQIIVFPEDGIHGFNFTRISIYPFLDLMPSPHLDKWNPCLEPQRFNDTEVLQRLSCMAIKGQMFLVANLGTKEPCHSSDPGCPDDGRYQFNTNVVFSSNGTLVSRYRKHNLYFEAAFDTPLEVDHSIFDTPFAGKFGTFTCFDILFFEPAVSILRDPEVKHIVYPTAWMNQLPLLAAIQIQRGFSIAFGINFLAANIHHPSLGMTGSGIHTPLKSFWHHDMESPEGRLIIAQIAKNPPGLISTGNTTSKMDIAHSKLLKILAGDLYSEKDAEDIHCDGAPEGNMSAPPTFNSEMMYDNFTLVPVWGKEGYLQVCADGLCCHLHYLRPTLSNELYSLGVFDGLHTVHGTYYVQACALVKCGGLGFDTCGQEITESTGIFDFHLWGNFSTSYIFPMLLTSGMTLETPDQVGWENGHYFLRKSGLSSGLVTAALYGRVYERD", "length": 514 }, "evidence": [ { "id": "F1MJM4", "url": "https://omabrowser.org/oma/group/F1MJM4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P43251-4", "protein_name": "Biotinidase", "gene_name": "BTD", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVAAVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCHSSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRFGIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAANVHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSKFLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATGIFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLYERD", "length": 523 }, "evidence": [ { "id": "F1MJM4", "url": "https://omabrowser.org/oma/group/F1MJM4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5FVF9-1", "protein_name": "Biotinidase", "gene_name": "Btd", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGARTAHALVFLLGCSALALGVCSASLEHGEAEYYVAAVYEHRSVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVFPEDGIHGFNFTRTSIYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMFLVANLGTKQPCLGSDPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPADVDLTTFDTPFAGKFGMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEIQKAFATAFGVTVLAANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQGLVGTENTTSEMDPSHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMYDNFTLVPVWGKEGHLQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQACALVKCGGAGFETCGQEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWESDHYFLRKRGLSSGLVTAALYGRLYERN", "length": 521 }, "evidence": [ { "id": "F1MJM4", "url": "https://omabrowser.org/oma/group/F1MJM4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CIF4-1", "protein_name": "Biotinidase", "gene_name": "Btd", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGARTAPALFFLGCSALALGVSSASQEHREAEYYVAAVYEHPSVLSPNPLELVSRQEALELMKQNLDVYEQQVMAAAQKGVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPKLVRWNPCLEPFRFNDTEVLQRLSCMAIKGGMFLVANLGTKQPCLSSDPGCPQDGRYQFNTNVVFSDNGTLVDRYRKHNLYFEAAFDTPANVDLITFDTPFAGKFGVFTCFDILFFDPAVRLLRDFEVKHIVYPTAWMNQLPLLAAIEIQKAFATAFGVNVLAANIHHPTLGMTGSGIHTPLKSFWYHDMDDPKGHLIIAQVATNPQGLTGTGNTTSEMDPSHRKFLKILSGDPYCEKDAQEVHCDEAAKWNVNVPPTFHSEMMYDNFTLVPVWGTEGHLQVCSNSLCCHLLYERPTLSKELYALGVFDGLHTVHGTYYIQTCALVKCGGLGFDTCGQEITEAEGLFDFHLWGNFSTLYIFPLFLTSGMTLDTPDQLGWENDHYFLRKRGLSSGLVTAALYGRLYERK", "length": 520 }, "evidence": [ { "id": "F1MJM4", "url": "https://omabrowser.org/oma/group/F1MJM4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NFP1-1", "protein_name": "Vanin-like protein 1", "gene_name": "vanin-like", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSNTWWWLSVVLLILGLMPGMSQQAALAESDYYTAGVVEFKQSILSLSAWSDSLAGYVEIINSENASATDIIVFPESTLNSAGSTTFVPNPEDQINPCLSDPNATYYEEFLVTLSCAARNASKYIVINLTEKQKCEDIPEDTRPCASNGLNVFNTNVVFDRQGVVVSRYRKVHLYGEAKNSTFLPELITFETDFGVTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLTAVQTQQGWAYANDVNLLASGASRPSIGNSGSGIYHGRSGTLTSVMRQDSGERAIYVAQVPKYTRSRSLKKRAKRSLQEIQTRQVASSSSFYMKRDYVENYESELLKLDEGTSGAINRTICQGSFCCNFDIAWRSLGTATENGSYYSYRLGTYDGWRNENNVDANYIRNCALFTCSGDSIDDCGKLLPTEGELQQSRVTFTRLAIGVTYPESREFLLFPDTLQDSLLPLEPSQFEWSQRKPTEDSYVQEVRFALKETQELSNLLTFGIYGNYYDNECTFGVGTEEEQLACGYRSGSPGLRILGGWLAMPLIILAIARTMSS", "length": 558 }, "evidence": [ { "id": "F1MJM4", "url": "https://omabrowser.org/oma/group/F1MJM4/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "biotin metabolic process", "id": "GO:0006768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006768", "evidence": [ { "database": "UniProtKB", "id": "F1MJM4", "url": "https://www.uniprot.org/uniprotkb/F1MJM4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "biotinidase activity", "id": "GO:0047708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047708", "evidence": [ { "database": "UniProtKB", "id": "F1MJM4", "url": "https://www.uniprot.org/uniprotkb/F1MJM4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 185, "end_pos": 187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 331, "end_pos": 333, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 471, "end_pos": 473, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "77171", "name": "", "equation": "biocytin + H2O = biotin + L-lysine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJM4-1", "A6QQ07-1" ], "evidence": [ { "id": "77171", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/77171" } ] }, { "id": "R-BTA-3076905", "name": "Extracellular BTD hydrolyses BCTN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region", "input_participant_list": [ "R-ALL-3076887" ], "output_participant_list": [ "R-ALL-351991" ], "enzyme_list": [ "F1MJM4-1" ], "evidence": [ { "id": "R-BTA-3076905", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3076905" } ] }, { "id": "R-BTA-4167509", "name": "Mitochondrial BTD hydrolyses BCTN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-3065953" ], "output_participant_list": [ "R-ALL-29582" ], "enzyme_list": [ "F1MJM4-1" ], "evidence": [ { "id": "R-BTA-4167509", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4167509" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29582", "participant_name": "Btn [mitochondrial matrix]", "crossref": [ { "id": "C00120", "database": "COMPOUND", "url": "" }, { "id": "ZINC000035024346", "database": "ZINC", "url": "" }, { "id": "15956", "database": "ChEBI", "url": "" }, { "id": "HMDB0000030", "database": "HMDB Metabolite", "url": "" }, { "id": "4787", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8143739", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-ALL-3065953", "participant_name": "BCTN [mitochondrial matrix]", "crossref": [ { "id": "195545", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-3076887", "participant_name": "BCTN [extracellular region]", "crossref": [ { "id": "195545", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-351991", "participant_name": "L-Lys [extracellular region]", "crossref": [ { "id": "ZINC000001532522", "database": "ZINC", "url": "" }, { "id": "32551", "database": "ChEBI", "url": "" }, { "id": "C00047", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A6QQ07", "gene_name": "BTD", "activity": [ { "ec_number": "3.5.1.12", "activity": "biocytin + H2O = biotin + L-lysine.", "evidence": [ { "id": "A6QQ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ07" } ] }, { "ec_number": "3.5.1.12", "activity": "", "evidence": [ { "id": "A6QQ07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6QQ07" } ] } ] }, { "uniprot_ac": "F1MJM4", "gene_name": "BTD", "activity": [ { "ec_number": "3.5.1.12", "activity": "biocytin + H2O = biotin + L-lysine.", "evidence": [ { "id": "F1MJM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJM4" } ] }, { "ec_number": "3.5.1.12", "activity": "", "evidence": [ { "id": "F1MJM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJM4" } ] } ] } ], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJM4" }, { "id": "PS50263", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50263" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CN hydrolase", "eco_id": "ECO_0000259", "start_pos": 54, "end_pos": 333, "start_aa": "Asp", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.5.1.12", "ec_name": "biocytin + H2O = biotin + L-lysine.", "evidence": [ { "id": "3.5.1.12", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.12" }, { "id": "3.5.1.12", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.1.12" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 }, { "start_pos": 132, "end_pos": 134 }, { "start_pos": 185, "end_pos": 187 }, { "start_pos": 331, "end_pos": 333 }, { "start_pos": 371, "end_pos": 373 }, { "start_pos": 384, "end_pos": 386 }, { "start_pos": 471, "end_pos": 473 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MKL5-1", "uniprot_ac": "F1MKL5", "uniprot_id": "F1MKL5_BOVIN", "mass": { "chemical_mass": 82496.0, "monoisotopic_mass": 82496.0 }, "refseq": {}, "gene_names": [ { "name": "ADAM3A", "type": "recommended", "evidence": [ { "id": "F1MKL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKL5" } ] } ], "protein_names": [ { "name": "ADAM metallopeptidase domain 3A (cyritestin 1)", "type": "synonym", "evidence": [ { "id": "F1MKL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKL5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MKL5", "url": "https://www.uniprot.org/uniprotkb/F1MKL5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADAM3A", "url": "https://www.uniprot.org/uniprotkb/F1MKL5", "locus": { "chromosome": "27", "start_pos": 34708242, "end_pos": 34822419, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000033312", "url": "https://www.ensembl.org/id/ENSBTAG00000033312" } ] } } ], "crossref": [ { "id": "F1MKL5", "url": "https://alphafold.ebi.ac.uk/entry/F1MKL5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000033312", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033312", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04269", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04269", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001762", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006586", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006586", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034027", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034027", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MKFFSSC", "url": "https://omabrowser.org/oma/group/MKFFSSC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11905", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11905", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11905:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11905:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00200", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00200", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01421", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01421", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01562", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01562", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MKL5", "url": "https://www.uniprot.org/uniprotkb/F1MKL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKL5-1", "url": "https://www.uniprot.org/uniprotkb/F1MKL5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLSLLLLLTGLGQLASAGHHSETARLQITVPRKIETNTKDGSISETHVAYSIQIDKKTYTLPLEKQSFLDSNLLVYSYNKSRVLYPDSSFIKGHCFYQGYATEIPNSVVTLSTCSGLRGLLQFENVSYGIEPLESSTTYEHVIYPFRDKKSDFSPISADQSYKILVKSNKDSGVLLKRVLKIHVIIDKALYHYMGSEVALASEKIIYVFSLINTMYSQLQVSVILTSLEIWSDLNKISTDGDAHDVLQRFVSWREKSLLQSSHDLAYLLIYRDHPNYVGATYHGMACDPKFAAGLALYSKMITLEAFSVIFTQLLGIMLGLKYNNNIYECSCPGIACIMNPEAIRSHGIKFFSSCSIDEFKHTTSQPKFECLQNRTVPKVVPQGRQSICGNGVLEPPEQCDCGSIENCEHTKCCNPLNCVLIGNADCGSGPCCGKKTCMILDRGTECRRSTDPCDFPEFCNGISEFCVPDMRAADLQTCNNKSSYCFRGICQDRTKQCVTLFGKYAKESSYQCTEEVNYQDDDFGNCLGRTCFFHQHLCGKLVCHWTHSAIVSRNDIDVQYTYLGGHICMSANLRTRRYPDPTVAANGSMCDENKFCDNGACRAIHQYTQYQDCDPLTKCKGHGICNTRLHCHCDVGYVPPDCEEIALSPGGSIDDGFWNLEIDESKTAYLIKRRRASQKNNLMISFYVLLPFFILTAIIALKWNKMKIFWNKEGTISGGSPSEISNSNSSQSNSND", "length": 737, "header": "tr|F1MKL5-1|F1MKL5_BOVIN Isoform 1 of ADAM metallopeptidase domain 3A (cyritestin 1) OS=Bos taurus OX=9913 GN=ADAM3A PE=4 SV=1 CANONICAL=F1MKL5-1" }, "isoforms": [ { "isoform_ac": "F1MKL5-1", "url": "https://www.uniprot.org/uniprotkb/F1MKL5/entry", "sequence": { "sequence": "MLSLLLLLTGLGQLASAGHHSETARLQITVPRKIETNTKDGSISETHVAYSIQIDKKTYTLPLEKQSFLDSNLLVYSYNKSRVLYPDSSFIKGHCFYQGYATEIPNSVVTLSTCSGLRGLLQFENVSYGIEPLESSTTYEHVIYPFRDKKSDFSPISADQSYKILVKSNKDSGVLLKRVLKIHVIIDKALYHYMGSEVALASEKIIYVFSLINTMYSQLQVSVILTSLEIWSDLNKISTDGDAHDVLQRFVSWREKSLLQSSHDLAYLLIYRDHPNYVGATYHGMACDPKFAAGLALYSKMITLEAFSVIFTQLLGIMLGLKYNNNIYECSCPGIACIMNPEAIRSHGIKFFSSCSIDEFKHTTSQPKFECLQNRTVPKVVPQGRQSICGNGVLEPPEQCDCGSIENCEHTKCCNPLNCVLIGNADCGSGPCCGKKTCMILDRGTECRRSTDPCDFPEFCNGISEFCVPDMRAADLQTCNNKSSYCFRGICQDRTKQCVTLFGKYAKESSYQCTEEVNYQDDDFGNCLGRTCFFHQHLCGKLVCHWTHSAIVSRNDIDVQYTYLGGHICMSANLRTRRYPDPTVAANGSMCDENKFCDNGACRAIHQYTQYQDCDPLTKCKGHGICNTRLHCHCDVGYVPPDCEEIALSPGGSIDDGFWNLEIDESKTAYLIKRRRASQKNNLMISFYVLLPFFILTAIIALKWNKMKIFWNKEGTISGGSPSEISNSNSSQSNSND", "length": 737, "header": "tr|F1MKL5-1|F1MKL5_BOVIN Isoform 1 of ADAM metallopeptidase domain 3A (cyritestin 1) OS=Bos taurus OX=9913 GN=ADAM3A PE=4 SV=1 CANONICAL=F1MKL5-1" }, "locus": { "chromosome": "27", "start_pos": 34822383, "end_pos": 34708406, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056907.2", "url": "https://www.ensembl.org/id/ENSBTAT00000056907.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049364.1", "url": "https://www.ensembl.org/id/ENSBTAP00000049364.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 583, "start_aa": "Thr", "end_pos": 583, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr583", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "F8VQ03-1", "protein_name": "A disintegrin and metallopeptidase domain 3", "gene_name": "Adam3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPLFLVLSYLGQVIAAGKDVETPLLQITVPEKIDTNIQDAKEAETQVTYVVRIEGKAYTLQLEKQSFLHPLFGTYLRDKLGTLQPYFSLVKTHCFYQGHAAEIPVSTVTLSTCSGLRGLLQLENITYGIEPLESSATFEHILYEIKNNKIDYSPLKENFANSEQESQSYRILVKPEKGSNSTLTKRILRIKIIMDKAMFDHMGSEVGVATQKVVHIFGLINTMFSQLKMTVMLNSLEIWSEQDKIETNGDADEVLQRFLLWKSKEISQKAQDITYLLLYKDHPDYVGATYHGMACNPNFTAGIALHPKTLAVEGFAIVLSQLLGINLGLAYDDVYNCFCPGSTCIMNPSAIRSQGIKVFSSCSVDEFKQLASQPELDCLRNTSETEFVVQPQGGSYCGNHLLEVPEQCDCGPPETCTHKKCCNPKDCTLIDAAQCGTGPCCDKRTCTIAERGRLCRKSKDQCDFPEFCNGETEGCAPDTKAADLEPCNNETAYCFGGVCRDPDRQCTDLFGKYAKGPNYVCAQEVNLQNDKFGNCHGRCNYSAIFCGKAVCYWNFAEVIQTEKYDVQYTYLGGQVCVSAHLRSQTGTRDDTYVHDGTVCGSGQVCFRGDCLRVHVLRGTRECEADDKCQGHGICNNLNNCQCESGFAPPECDMTPSSPGGSMDDGFWLPFDKSTPLIFKRHGLKYKKVLLISFYILLPFLVVLAFMAVKRMIGKRLAKQNISKALEHKEEAFNRGSMNPGVVSGGNTDQNLMTVPGSFNSYAYHGNTDQNFMTVPGSFNSYSYHGNTDQNFMTVPGSFNSYSYQDVPYYRSIPEDGNDSQQ", "length": 822 }, "evidence": [ { "id": "F1MKL5", "url": "https://omabrowser.org/oma/group/F1MKL5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "F1MKL5", "url": "https://www.uniprot.org/uniprotkb/F1MKL5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MKL5", "url": "https://www.uniprot.org/uniprotkb/F1MKL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1MKL5", "url": "https://www.uniprot.org/uniprotkb/F1MKL5" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1MKL5", "url": "https://www.uniprot.org/uniprotkb/F1MKL5" } ], "pmid": "" }, { "name": "binding of sperm to zona pellucida", "id": "GO:0007339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007339", "evidence": [ { "database": "UniProtKB", "id": "F1MKL5", "url": "https://www.uniprot.org/uniprotkb/F1MKL5" } ], "pmid": "" }, { "name": "male gonad development", "id": "GO:0008584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008584", "evidence": [ { "database": "UniProtKB", "id": "F1MKL5", "url": "https://www.uniprot.org/uniprotkb/F1MKL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 374, "end_pos": 376, "annotation": "n_glycosylation_sequon" }, { "start_pos": 481, "end_pos": 483, "annotation": "n_glycosylation_sequon" }, { "start_pos": 587, "end_pos": 589, "annotation": 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"Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 610, "end_pos": 644, "start_aa": "Gln", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MKL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKL5" }, { "id": "PS50215", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50215" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M12B", "eco_id": "ECO_0000259", "start_pos": 178, "end_pos": 376, "start_aa": "Arg", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 583 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 125, "end_pos": 127 }, { "start_pos": 374, "end_pos": 376 }, { "start_pos": 481, "end_pos": 483 }, { "start_pos": 587, "end_pos": 589 }, { "start_pos": 729, "end_pos": 731 }, { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051355", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051355", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MLJ7", "url": "https://www.orthodb.org/?gene=F1MLJ7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45836", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45836", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45836:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45836:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00054", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00054", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00560", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00560", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01462", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01462", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01463", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01463", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12661", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12661", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-376176", "url": 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"id": "A0AAA9TY67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TY67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY67-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLJ7-1", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHGVGWQTLSLSLGLVLAILNEVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKITTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTSKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNHISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNSIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLTKIPDHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRISCVGNDSFIGLSSVRLLSLYDNQITTIAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPAECTCLDTVVRCSNKALKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLAALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNNDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEKDGFWCICADGFEGENCEINVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGYKCDCTPGYIGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCTCPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIIRINEPICQCLPGYQGEKCEKLVSVNFVNKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGSPKIITNLSKQSTLNFDSPLYVGGMPGKNNVAAALRQAPGQNGTSFHGCIRNLYINSELQDFRKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECEEGWTGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCAS", "length": 1530, "header": "tr|F1MLJ7-1|F1MLJ7_BOVIN Isoform 1 of Slit homolog 2 protein OS=Bos taurus OX=9913 GN=SLIT2 PE=4 SV=4 CANONICAL=F1MLJ7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TWU5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWU5/entry", "sequence": { "sequence": "MHGVGWQTLSLSLGLVLAILNEVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKITTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTSKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNHISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSDEEEGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNSIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLTKIPDHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRISCVGNDSFIGLSSVRLLSLYDNQITTIAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPAECTCLDTVVRCSNKALKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLAALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNNDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEKDGFWCICADGFEGENCEINVDDCEDNDCENNSTCVDGINNYTCLCPPEYTAANLNEVEKGELCEEKLDFCAQDLNPCQHDSKCILTPKGYKCDCTPGYIGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCTCPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIIRINEPICQCLPGYQGEKCEKLVSVNFVNKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGSPKIITNLSKQSTLNFDSPLYVGGMPGKNNVAAALRQAPGQNGTSFHGCIRNLYINSELQDFRKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECEEGWTGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCAS", "length": 1543, "header": "tr|A0AAA9TWU5-1|F1MLJ7_BOVIN Computationally mapped isoform of Slit homolog 2 protein OS=Bos taurus OX=9913 GN=SLIT2 PE=4 SV=1 CANONICAL=F1MLJ7-1" }, "locus": { "chromosome": "6", "start_pos": 40182887, "end_pos": 39779895, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133943.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133943.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101061.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101061.1" } ] } }, { "isoform_ac": "A0AAA9TY67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TY67/entry", "sequence": { "sequence": "MHGVGWQTLSLSLGLVLAILNEVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKITTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTSKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNHISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSDEEEGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNSIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLTKIPDHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRISCVGNDSFIGLSSVRLLSLYDNQITTIAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPAECTCLDTVVRCSNKALKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLAALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNNDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEKDGFWCICADGFEGENCEINVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGYKCDCTPGYIGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCTCPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIIRINEPICQCLPGYQGEKCEKLVSVNFVNKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGSPKIITNLSKQSTLNFDSPLYVGGMPGKNNVAAALRQAPGQNGTSFHGCIRNLYINSELQDFRKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECEEGWTGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCAS", "length": 1526, "header": "tr|A0AAA9TY67-1|F1MLJ7_BOVIN Computationally mapped isoform of Slit homolog 2 protein OS=Bos taurus OX=9913 GN=SLIT2 PE=4 SV=1 CANONICAL=F1MLJ7-1" }, "locus": { "chromosome": "6", "start_pos": 40182887, "end_pos": 39779895, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129386.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129386.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102452.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102452.1" } ] } }, { "isoform_ac": "F1MLJ7-1", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7/entry", "sequence": { "sequence": "MHGVGWQTLSLSLGLVLAILNEVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKITTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTSKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNHISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNSIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLTKIPDHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRISCVGNDSFIGLSSVRLLSLYDNQITTIAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPAECTCLDTVVRCSNKALKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLAALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNNDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEKDGFWCICADGFEGENCEINVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGYKCDCTPGYIGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCTCPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIIRINEPICQCLPGYQGEKCEKLVSVNFVNKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGSPKIITNLSKQSTLNFDSPLYVGGMPGKNNVAAALRQAPGQNGTSFHGCIRNLYINSELQDFRKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECEEGWTGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGCTRCAS", "length": 1530, "header": "tr|F1MLJ7-1|F1MLJ7_BOVIN Isoform 1 of Slit homolog 2 protein OS=Bos taurus OX=9913 GN=SLIT2 PE=4 SV=4 CANONICAL=F1MLJ7-1" }, "locus": { "chromosome": "6", "start_pos": 40182887, "end_pos": 39779895, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061059.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061059.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053607.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053607.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-376176", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-376176", "resource": "Reactome", "description": "Signaling by ROBO receptors" }, { "id": "R-BTA-428890", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-428890", "resource": "Reactome", "description": "Role of ABL in ROBO-SLIT signaling" }, { "id": "R-BTA-8985586", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8985586", "resource": "Reactome", "description": "SLIT2:ROBO1 increases RHOA activity" }, { "id": "R-BTA-9010553", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9010553", "resource": "Reactome", "description": "Regulation of expression of SLITs and ROBOs" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 40, "go_terms": [ { "name": "negative regulation of retinal ganglion cell axon guidance", "id": "GO:0090260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090260", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "regulation of axonogenesis", "id": "GO:0050770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050770", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "negative regulation of chemokine-mediated signaling pathway", "id": "GO:0070100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070100", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "corticospinal neuron axon guidance through spinal cord", "id": "GO:0021972", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021972", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "induction of negative chemotaxis", "id": "GO:0050929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050929", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "positive regulation of apoptotic process", "id": "GO:0043065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "negative regulation of small GTPase mediated signal transduction", "id": "GO:0051058", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051058", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "negative regulation of vascular permeability", "id": "GO:0043116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043116", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "cellular response to hormone stimulus", "id": "GO:0032870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032870", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "negative regulation of cell growth", "id": "GO:0030308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "negative regulation of endothelial cell migration", "id": "GO:0010596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010596", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "negative regulation of smooth muscle cell chemotaxis", "id": "GO:0071672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071672", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "cellular response to heparin", "id": "GO:0071504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071504", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "ureteric bud development", "id": "GO:0001657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001657", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "regulation of neurogenesis", "id": "GO:0050767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050767", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "negative regulation of cellular response to growth factor stimulus", "id": "GO:0090288", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090288", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "response to cortisol", "id": "GO:0051414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051414", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "chemorepulsion involved in postnatal olfactory bulb interneuron migration", "id": "GO:0021836", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021836", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "apoptotic process involved in luteolysis", "id": "GO:0061364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061364", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "motor neuron axon guidance", "id": "GO:0008045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008045", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "cell migration involved in sprouting angiogenesis", "id": "GO:0002042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002042", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "negative regulation of actin filament polymerization", "id": "GO:0030837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030837", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "negative regulation of neutrophil chemotaxis", "id": "GO:0090024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090024", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "retinal ganglion cell axon guidance", "id": "GO:0031290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031290", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "branching morphogenesis of an epithelial tube", "id": "GO:0048754", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048754", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "negative regulation of mononuclear cell migration", "id": "GO:0071676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071676", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "Roundabout signaling pathway", "id": "GO:0035385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035385", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "axon extension involved in axon guidance", "id": "GO:0048846", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048846", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "negative regulation of lamellipodium assembly", "id": "GO:0010593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010593", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "negative regulation of macromolecule metabolic process", "id": "GO:0010605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010605", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "regulation of cellular component size", "id": "GO:0032535", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032535", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "epithelial tube morphogenesis", "id": "GO:0060562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060562", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": "https://www.uniprot.org/uniprotkb/F1MLJ7" } ], "pmid": "" }, { "name": "circulatory system development", "id": "GO:0072359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072359", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ7", "url": 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"tr|F1MLG1-1|F1MLG1_BOVIN Isoform 1 of Signal recognition particle receptor subunit beta OS=Bos taurus OX=9913 GN=SRPRB PE=1 SV=3 CANONICAL=F1MLG1-1" }, "locus": { "chromosome": "1", "start_pos": 135572619, "end_pos": 135533133, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061601.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061601.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053290.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053290.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "P47758-1", "protein_name": "Signal recognition particle receptor subunit beta", "gene_name": "Srprb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASANTRRVGDGAGGAFQPYLDSLRQELQQRDPTLLSVAVALLAVLLTLVFWKFIWSRKSSQRAVLFVGLCDSGKTLLFVRLLTGQYRDTQTSITDSSAIYKVNNNRGNSLTLIDLPGHESLRFQLLDRFKSSARAVVFVVDSAAFQREVKDVAEFLYQVLIDSMALKNSPSLLIACNKQDIAMAKSAKLIQQQLEKELNTLRVTRSAAPSTLDSSSTAPAQLGKKGKEFEFSQLPLKVEFLECSAKGGRGDTGSADIQDLEKWLAKIA", "length": 269 }, "evidence": [ { "id": "F1MLG1", "url": "https://omabrowser.org/oma/group/F1MLG1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y5M8-1", "protein_name": "Signal recognition particle receptor subunit beta", "gene_name": "SRPRB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASADSRRVADGGGAGGTFQPYLDTLRQELQQTDPTLLSVVVAVLAVLLTLVFWKLIRSRRSSQRAVLLVGLCDSGKTLLFVRLLTGLYRDTQTSITDSCAVYRVNNNRGNSLTLIDLPGHESLRLQFLERFKSSARAIVFVVDSAAFQREVKDVAEFLYQVLIDSMGLKNTPSFLIACNKQDIAMAKSAKLIQQQLEKELNTLRVTRSAAPSTLDSSSTAPAQLGKKGKEFEFSQLPLKVEFLECSAKGGRGDVGSADIQDLEKWLAKIA", "length": 271 }, "evidence": [ { "id": "F1MLG1", "url": "https://omabrowser.org/oma/group/F1MLG1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1MLG1", "url": "https://www.uniprot.org/uniprotkb/F1MLG1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1MLG1", "url": "https://www.uniprot.org/uniprotkb/F1MLG1" } ], "pmid": "" }, { "name": "cytoplasmic microtubule", "id": "GO:0005881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005881", "evidence": [ { "database": "UniProtKB", "id": "F1MLG1", "url": "https://www.uniprot.org/uniprotkb/F1MLG1" } ], "pmid": "" }, { "name": "signal recognition particle receptor complex", "id": "GO:0005785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005785", "evidence": [ { "database": "UniProtKB", "id": "F1MLG1", "url": "https://www.uniprot.org/uniprotkb/F1MLG1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein targeting to ER", "id": "GO:0045047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045047", "evidence": [ { "database": "UniProtKB", "id": "F1MLG1", "url": "https://www.uniprot.org/uniprotkb/F1MLG1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MN04-1", "uniprot_ac": "F1MN04", "uniprot_id": "F1MN04_BOVIN", "mass": { "chemical_mass": 100650.0, "monoisotopic_mass": 100650.0 }, "refseq": {}, "gene_names": [ { "name": "PAICS", "type": "recommended", "evidence": [ { "id": "F1MN04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN04" } ] } ], "protein_names": [ { "name": "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase", "type": "recommended", "evidence": [ { "id": "F1MN04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN04/entry#names_and_taxonomy" } ] }, { "name": "4.1.1.21", "type": "synonym", "evidence": [ { "id": "F1MN04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN04/entry#names_and_taxonomy" } ] }, { "name": "6.3.2.6", "type": "synonym", "evidence": [ { "id": "F1MN04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN04/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SR93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR93#function" }, { "database": "UniProtKB", "id": "ARBA00054522", "url": "https://www.uniprot.org/uniprotkb/ARBA00054522#function" }, { "database": "UniProtKB", "id": "A0AAA9SUB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUB3#function" }, { "database": "UniProtKB", "id": "A0ABI0NKF1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKF1#function" }, { "database": "UniProtKB", "id": "F1MN04", "url": "https://www.uniprot.org/uniprotkb/F1MN04#function" }, { "database": "UniProtKB", "id": "F6QZ79", "url": "https://www.uniprot.org/uniprotkb/F6QZ79#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MN04", "url": "https://www.uniprot.org/uniprotkb/F1MN04" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PAICS", "url": "https://www.uniprot.org/uniprotkb/F1MN04", "locus": {} } ], "crossref": [ { "id": "F1MN04", "url": "https://alphafold.ebi.ac.uk/entry/F1MN04", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010577", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010577", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01416", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01416", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "404170", "url": "https://www.ncbi.nlm.nih.gov/gene/404170", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000031", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000031", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028923", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028923", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033626", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033626", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044822", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044822", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050089", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050089", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MN04", "url": "https://www.orthodb.org/?gene=F1MN04", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43599", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43599", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43599:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43599:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00731", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00731", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01259", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01259", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13837", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13837", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "10792", "url": "https://www.rhea-db.org/rhea/10792", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "22628", "url": "https://www.rhea-db.org/rhea/22628", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SR93", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SR93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUB3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKF1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NKF1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN04", "url": "https://www.uniprot.org/uniprotkb/F1MN04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN04-1", "url": "https://www.uniprot.org/uniprotkb/F1MN04-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QZ79", "url": "https://www.uniprot.org/uniprotkb/F6QZ79", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6QZ79-1", "url": "https://www.uniprot.org/uniprotkb/F6QZ79-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESGAGKHWTEEEVKALLSVWAEKNIRKQLYGTLRNKGIFIYIAKRLRALGVYRDWKQCRAKYKNLKYEYRTVKYALNSGDSSKTMKFFHDLDAILQYEPATPLTEEDANDRCLATLSPSAVPETTEGKMSVTSEDKEDISGNPLLLVSQVRPMELGDSTAIMEPPGNSTVIPTVANEGGKHWTVPEVRALIGIWSDQGIQQQLEGTMRNKRIFEQIAAKLQKLGIERDWKQCRTKYKNLKHEYKIVRTARDLGMAKSMKFFTELDAILGHKKTENSQQECQDEEQATGCAHVKMEEDQTVIAGDAAEDALVSNMSGDLTETDMRQSPCTEEDTASNASDEVGGPTAPHGIPGSELFENHTKNPRTLSIKRKALEDACQAPLSMEFSRQEYWSGFPCPPPGDLSNSGIEPASLASPALTEPASVSLKKTASETAANQLTQRTTEPKDSSEYFCSQETPYVTQLHQSPASLRSAAEGLRPLRTMAAVEVLKIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPKCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVEMFFKDDANNDPQWSEEQLIAANFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVITREIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKPESQCRVIVLMGSTSDLNHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVLSGNTAYPVISCPPLTPDWGAQDVWSSLRLPSGLGCSTILSPEGSAQFAAQIFGLNNHLIWARLRASVLNTWISLKQADKKIREASL", "length": 907, "header": "tr|F1MN04-1|F1MN04_BOVIN Isoform 1 of Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Bos taurus OX=9913 GN=PAICS PE=3 SV=5 CANONICAL=F1MN04-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SR93-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SR93/entry", "sequence": { "sequence": "MESGAGKHWTEEEVKALLSVWAEKNIRKQLYGTLRNKGIFIYIAKRLRALGVYRDWKQCRAKYKNLKYEYRTVKYALNSGDSSKTMKFFHDLDAILQYEPATPLTEEDANDRCLATLSPSAVPETTEGKMSVTSEDKEDISGNPLLLVSQVRPMELGDSTAIMEPPGNSTVIPTVANEGGKHWTVPEVRALIGIWSDQGIQQQLEGTMRNKRIFEQIAAKLQKLGIERDWKQCRTKYKNLKHEYKIVRTARDLGMAKSMKFFTELDAILGHKKTENSQQECQDEEQATGCAHVKMEEDQTVIAGDAAEDALVSNMSGDLTETDMRQSPCTEEDTASNASDEVGGPTAPHGIPGSELFENHTKNPRTLSIKRKALEDEPASVSLKKTASETAANQLTQRTTEPKDSSEYFCSQETPYVTQLHQSPASLRSAAEGLRPLRTMAAVEVLKIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPKCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVEMFFKDDANNDPQWSEEQLIAANFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVITREIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKPESQCRVIVLMGSTSDLNHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVLSGNTAYPVISCPPLTPDWGAQDVWSSLRLPSGLGCSTILSPEGSAQFAAQIFGLNNHLIWARLRASVLNTWISLKQADKKIREASL", "length": 864, "header": "tr|A0AAA9SR93-1|F1MN04_BOVIN Computationally mapped isoform of Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Bos taurus OX=9913 GN=PAICS PE=3 SV=2 CANONICAL=F1MN04-1" }, "locus": { "chromosome": "6", "start_pos": 71841274, "end_pos": 71796672, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124501.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124501.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085490.2", "url": "https://www.ensembl.org/id/ENSBTAP00000085490.2" } ] } }, { "isoform_ac": "A0AAA9SUB3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUB3/entry", "sequence": { "sequence": "MESGAGKHWTEEEVKALLSVWAEKNIRKQLYGTLRNKGIFIYIAKRLRALGVYRDWKQCRAKYKNLKYEYRTVKYALNSGDSSKTMKFFHDLDAILQYEPATPLTEEDANDRCLATLSPSAVPETTEGKMSVTSEDKEDISGNPLLLVSQVRPMELGDSTAIMEPPGNSTVIPTVANEGGKHWTVPEVRALIGIWSDQGIQQQLEGTMRNKRIFEQIAAKLQKLGIERDWKQCRTKYKNLKHEYKIVRTARDLGMAKSMKFFTELDAILGHKKTENSQQECQDEEQATGCAHVKMEEDQTEEDTASNASDEVGGPTAPHGIPGSELFENHTKNPRTLSIKRKALEDACQAPLSMEFSRQEYWSGFPCPPPGDLSNSGIEPASLASPALTEPASVSLKKTASETAANQLTQRTTEPKDSSEYFCSQETPYVTQLHQSPASLRSAAEGLRPLRTMAAVEVLKIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPKCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVEMFFKDDANNDPQWSEEQLIAANFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVITREIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKPESQCRVIVLMGSTSDLNHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVLSGNTAYPVISCPPLTPDWGAQDVWSSLRLPSGLGCSTILSPEGSAQFAAQIFGLNNHLIWARLRASVLNTWISLKQADKKIREASL", "length": 877, "header": "tr|A0AAA9SUB3-1|F1MN04_BOVIN Computationally mapped isoform of Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Bos taurus OX=9913 GN=PAICS PE=3 SV=2 CANONICAL=F1MN04-1" }, "locus": { "chromosome": "6", "start_pos": 71841274, "end_pos": 71796672, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112854.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112854.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086709.2", "url": "https://www.ensembl.org/id/ENSBTAP00000086709.2" } ] } }, { "isoform_ac": "A0ABI0NKF1-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NKF1/entry", "sequence": { "sequence": "MSLLICFSPSRHYLSPASLRSAAEGLRPLRTMAAVEVLKIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPKCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVEMFFKDDANNDPQWSEEQLIAANFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVITREIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKPESQCRVIVLMGSTSDLNHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVLSGNTAYPVISCPPLTPDWGAQDVWSSLRLPSGLGCSTILSPEGSAQFAAQIFGLNNHLIWARLRASVLNTWISLKQADKKIREASL", "length": 456, "header": "tr|A0ABI0NKF1-1|A0ABI0NKF1_BOVIN Computationally mapped isoform of Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Bos taurus OX=9913 GN=PAICS PE=3 SV=1 CANONICAL=F1MN04-1" }, "locus": { "chromosome": "6", "start_pos": 71841274, "end_pos": 71822047, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000144901.1", "url": "https://www.ensembl.org/id/ENSBTAT00000144901.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105181.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105181.1" } ] } }, { "isoform_ac": "F1MN04-1", "url": "https://www.uniprot.org/uniprotkb/F1MN04/entry", "sequence": { "sequence": "MESGAGKHWTEEEVKALLSVWAEKNIRKQLYGTLRNKGIFIYIAKRLRALGVYRDWKQCRAKYKNLKYEYRTVKYALNSGDSSKTMKFFHDLDAILQYEPATPLTEEDANDRCLATLSPSAVPETTEGKMSVTSEDKEDISGNPLLLVSQVRPMELGDSTAIMEPPGNSTVIPTVANEGGKHWTVPEVRALIGIWSDQGIQQQLEGTMRNKRIFEQIAAKLQKLGIERDWKQCRTKYKNLKHEYKIVRTARDLGMAKSMKFFTELDAILGHKKTENSQQECQDEEQATGCAHVKMEEDQTVIAGDAAEDALVSNMSGDLTETDMRQSPCTEEDTASNASDEVGGPTAPHGIPGSELFENHTKNPRTLSIKRKALEDACQAPLSMEFSRQEYWSGFPCPPPGDLSNSGIEPASLASPALTEPASVSLKKTASETAANQLTQRTTEPKDSSEYFCSQETPYVTQLHQSPASLRSAAEGLRPLRTMAAVEVLKIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPKCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVEMFFKDDANNDPQWSEEQLIAANFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVITREIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKPESQCRVIVLMGSTSDLNHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVLSGNTAYPVISCPPLTPDWGAQDVWSSLRLPSGLGCSTILSPEGSAQFAAQIFGLNNHLIWARLRASVLNTWISLKQADKKIREASL", "length": 907, "header": "tr|F1MN04-1|F1MN04_BOVIN Isoform 1 of Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Bos taurus OX=9913 GN=PAICS PE=3 SV=5 CANONICAL=F1MN04-1" }, "locus": { "chromosome": "6", "start_pos": 71841274, "end_pos": 71796672, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013985.8", "url": "https://www.ensembl.org/id/ENSBTAT00000013985.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013985.8", "url": "https://www.ensembl.org/id/ENSBTAP00000013985.8" } ] } }, { "isoform_ac": "F6QZ79-1", "url": "https://www.uniprot.org/uniprotkb/F6QZ79/entry", "sequence": { "sequence": "MESGAGKHWTEEEVKALLSVWAEKNIRKQLYGTLRNKGIFIYIAKRLRALGVYRDWKQCRAKYKNLKYEYRTVKYALNSGDSSKTMKFFHDLDAILQYEPATPLTEEDANDRCLATLSPSAVPETTEGKMSVTSEDKEDISGNPLLLVSQVRPMELGDSTAIMEPPGNSTVIPTVANEGGKHWTVPEVRALIGIWSDQGIQQQLEGTMRNKRIFEQIAAKLQKLGIERDWKQCRTKYKNLKHEYKIVRTARDLGMAKSMKFFTELDAILGHKKTENSQQECQDEEQATGCAHVKMEEDQTVIAGDAAEDALVSNMSGDLTETDMRQSPCTEEDTASNASDEVGGPTAPHGIPGSEPASVSLKKTASETAANQLTQRTTEPKDSSEYFCSQETPYVTQLHQSPASLRSAAEGLRPLRTMAAVEVLKIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPKCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVEMFFKDDANNDPQWSEEQLIAANFCFAGLVIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVITREIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKPESQCRVIVLMGSTSDLNHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVLSGNTAYPVISCPPLTPDWGAQDVWSSLRLPSGLGCSTILSPEGSAQFAAQIFGLNNHLIWARLRASVLNTWISLKQADKKIREASL", "length": 842, "header": "tr|F6QZ79-1|F1MN04_BOVIN Computationally mapped isoform of Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Bos taurus OX=9913 GN=PAICS PE=3 SV=2 CANONICAL=F1MN04-1" }, "locus": { "chromosome": "6", "start_pos": 71841274, "end_pos": 71796672, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000046275.5", "url": "https://www.ensembl.org/id/ENSBTAT00000046275.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000043590.4", "url": "https://www.ensembl.org/id/ENSBTAP00000043590.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 346, "start_aa": "Thr", "end_pos": 346, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr346", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MN04", "url": "https://www.uniprot.org/uniprotkb/F1MN04" } ], "pmid": "" }, { "name": "phosphoribosylaminoimidazolesuccinocarboxamide synthase activity", "id": "GO:0004639", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004639", "evidence": [ { "database": "UniProtKB", "id": "F1MN04", "url": "https://www.uniprot.org/uniprotkb/F1MN04" } ], "pmid": "" }, { "name": "carboxy-lyase activity", "id": "GO:0016831", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016831", "evidence": [ { "database": "UniProtKB", "id": "F1MN04", "url": "https://www.uniprot.org/uniprotkb/F1MN04" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "'de novo' IMP biosynthetic process", "id": "GO:0006189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006189", "evidence": [ { "database": "UniProtKB", "id": "F1MN04", "url": "https://www.uniprot.org/uniprotkb/F1MN04" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 168, "end_pos": 170, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" }, { "start_pos": 359, "end_pos": 361, "annotation": "n_glycosylation_sequon" }, { "start_pos": 666, "end_pos": 668, "annotation": "n_glycosylation_sequon" }, { "start_pos": 693, "end_pos": 695, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10792", "name": "", "equation": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MN04-1" ], "evidence": [ { "id": "10792", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10792" } ] }, { "id": "22628", "name": "", "equation": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + phosphate + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MN04-1" ], "evidence": [ { "id": "22628", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22628" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MN04", "gene_name": "PAICS", "activity": [ { "ec_number": "4.1.1.21", "activity": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2.", "evidence": [ { "id": "F1MN04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN04" } ] }, { "ec_number": "6.3.2.6", "activity": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + phosphate + 2 H(+).", "evidence": [ { "id": "F1MN04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN04" } ] }, { "ec_number": "4.1.1.21", "activity": "", "evidence": [ { "id": "F1MN04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN04" } ] }, { "ec_number": "6.3.2.6", "activity": "", "evidence": [ { "id": "F1MN04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN04" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MN04-F1", "pdb_chain": "global", "start_pos": 1, 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"ECO_0000259", "start_pos": 748, "end_pos": 895, "start_aa": "Cys", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "4.1.1.21", "ec_name": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2.", "evidence": [ { "id": "4.1.1.21", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.21" }, { "id": "4.1.1.21", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=4.1.1.21" } ] }, { "ec_number": "6.3.2.6", "ec_name": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + phosphate + 2 H(+).", "evidence": [ { "id": "6.3.2.6", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.6" }, { "id": "6.3.2.6", "database": "BRENDA Enzymes", "url": 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M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.", "evidence": [ { "database": "UniProtKB", "id": "F1MPB1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1#function" }, { "database": "UniProtKB", "id": "ARBA00057240", "url": "https://www.uniprot.org/uniprotkb/ARBA00057240#function" }, { "database": "UniProtKB", "id": "A0A3Q1LL10", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL10#function" }, { "database": "UniProtKB", "id": "A0A3Q1LVS0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVS0#function" }, { "database": "UniProtKB", "id": "A0A3Q1M570", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M570#function" }, { "database": "UniProtKB", "id": "A0AAA9T8L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MPB1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GNPTAB", "url": "https://www.uniprot.org/uniprotkb/F1MPB1", "locus": { "chromosome": "5", "start_pos": 65572867, "end_pos": 65676444, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019409", "url": "https://www.ensembl.org/id/ENSBTAG00000019409" } ] } } ], "crossref": [ { "id": "F1MPB1", "url": "https://alphafold.ebi.ac.uk/entry/F1MPB1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019409", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019409", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd21599", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21599", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21600", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21600", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "509610", "url": "https://www.ncbi.nlm.nih.gov/gene/509610", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000800", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010506", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010506", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021520", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021520", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031358", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031358", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047141", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047141", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LL10", "url": "https://www.orthodb.org/?gene=A0A3Q1LL10", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVS0", "url": "https://www.orthodb.org/?gene=A0A3Q1LVS0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M570", "url": "https://www.orthodb.org/?gene=A0A3Q1M570", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MPB1", "url": "https://www.orthodb.org/?gene=F1MPB1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24045", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24045", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24045:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24045:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00066", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00066", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06464", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06464", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF11380", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11380", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17101", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17101", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17102", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17102", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17103", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17103", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18440", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18440", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF26737", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF26737", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "13581", "url": "https://www.rhea-db.org/rhea/13581", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LL10", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LL10-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL10-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVS0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVS0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVS0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVS0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M570", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M570", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M570-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M570-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T293", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T293", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T293-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T293-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8L7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T8L7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPB1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPB1-1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLKLLQRQTYTCLSHRYGLYVCFVGVVVTIVSAFQFGEVVLEWSRDQYHVLFDSYRDNIAGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREQMEEEQKAMREILGKNTTEPTKKSEKPLECLLTHCIKVPMLVLDPALPTNVTLKDLPSLYPSFHSASDVFNVAKPKNPSTNVSVVVFDTTKSVEDAQAGMFKGNSRQTVWRGYLTTDKEVPGLVLMQDLAFLSGFPPTFKETNQLKAKLPENLSSKIKLLQLYSEASVALLKLNNPKDFQELNKQTKKNMTINGKELTISPAYLLWDLSAISQSKQDEDVSASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCSGNSGASRYIAGAGGTGSIGVGQPWHFGAGMTGVSYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQVMFVFFPLDHFHELYKVTLLPNQTHYVVPKGECLPYFSFAEIAKKGIEGAYSDNPIIRHASIANKWKTIHLLMHSGMNATTIHFNLTLQGKNDEEFKIQIVVEVDTREEPKRNSTTQKAYQSSMSSTTLLPEAEILFEDIPEEKRFPKVKRHDVNTTRRFQVEVEIPQVNISLLPKETQLSLNNLDLQLERGDITMKGYNLSKSALLRSFLMNPQNGKLTVNHPLTTEQRNGGLEAPLAKDAHKSNLGTSERRQGSSPVPAVTMTVNNHSQSQIPPLEARFRAITVTPKVGGRTVSREKLSSLTFPLESKDTQEKVITGKEQEKKIEENANSYPGGNEVVPGRKLQQYTDSYLGFLPWEKKKYFQDLLDEEESLKTQLAYFTDSKHTGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNISQVFDEVDTDQSGILSDREIRTLATRIHDLPLSLQDLTGLEHMLINCSKMLPANITQLNNIPPTQEAYYDPNLPPVTKSLVTNCKPVTDKIHKAFKDKNKYRFEIMGEEEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAVLRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAYRDKLKFWTHCVLATLIMFTVFSFFAEQLIALKRKIFPRRRIHKEASPDRIRV", "length": 1257, "header": "tr|F1MPB1-1|F1MPB1_BOVIN Isoform 1 of N-acetylglucosamine-1-phosphotransferase subunits alpha/beta OS=Bos taurus OX=9913 GN=GNPTAB PE=3 SV=3 CANONICAL=F1MPB1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LL10-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL10/entry", "sequence": { "sequence": "MKPHNQLLLFGLINVVLEWSRDQYHVLFDSYRDNIAGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREQMEEEQKAMREILGKNTTEPTKKSEKPLECLLTHCIKVPMLVLDPALPTNVTLKDLPSLYPSFHSASDVFNVAKPKNPSTNVSVVVFDTTKSVEDAQAGMFKGNSRQTVWRGYLTTDKEVPGLVLMQDLAFLSGFPPTFKETNQLKAKLPENLSSKIKLLQLYSEASVALLKLNNPKDFQELNKQTKKNMTINGKELTISPAYLLWDLSAISQSKQDEDVSASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCSGNSGASRYIAGAGGTGSIGVGQPWHFGAGMTGVSYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQDHFHELYKVTLLPNQTHYVVPKGECLPYFSFAEIAKKGIEGAYSDNPIIRHASIANKWKTIHLLMHSGMNATTIHFNLTLQGKNDEEFKIQIVVEVDTREEPKRNSTTQKAYQSSMSSTTLLPEAEILFEDIPEEKRFPKVKRHDVNTTRRFQVEVEIPQVNISLLPKETQLSLNNLDLQLERGDITMKGYNLSKSALLRSFLMNPQNGKLTVNHPLTTEQRNGGLEAPLAKDAHKSNLGTSERRQGSSPVPAVTMTVNNHSQSQIPPLEARFRAITVTPKVGGRTVSREKLSSLTFPLESKDTQEKVITGKEQEKKIEENANSYPGGNEVVPGRKLQQYTDSYLGFLPWEKKKYFQDLLDEEESLKTQLAYFTDSKHTGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNISQVFDEVDTDQSGILSDREIRTLATRIHDLPLSLQDLTGLEHMLINCSKMLPANITQLNNIPPTQEAYYDPNLPPVTKSLVTNCKPVTDKIHKAFKDKNKYRFEIMGEEEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAVLRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAYRDKLKFWTHCVLATLIMFTVFSFFAEQLIALKRKIFPRRRIHKEASPDRIRV", "length": 1224, "header": "tr|A0A3Q1LL10-1|F1MPB1_BOVIN Computationally mapped isoform of N-acetylglucosamine-1-phosphotransferase subunits alpha/beta OS=Bos taurus OX=9913 GN=GNPTAB PE=3 SV=2 CANONICAL=F1MPB1-1" }, "locus": { "chromosome": "5", "start_pos": 65676420, "end_pos": 65573537, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083649.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083649.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060428.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060428.2" } ] } }, { "isoform_ac": "A0A3Q1LVS0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVS0/entry", "sequence": { "sequence": "MVVLEWSRDQYHVLFDSYRDNIAGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREQMEEEQKAMREILGKNTTEPTKKSEKPLECLLTHCIKVPMLVLDPALPTNVTLKDLPSLYPSFHSASDVFNVAKPKNPSTNVSVVVFDTTKSVEDAQAGMFKGNSRQTVWRGYLTTDKEVPGLVLMQDLAFLSGFPPTFKETNQLKAKLPENLSSKIKLLQLYSEASVALLKLNNPKDFQELNKQTKKNMTINGKELTISPAYLLWDLSAISQSKQDEDVSASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCSGNSGASRYIAGAGGTGSIGVGQPWHFGAGMTGVSYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQDHFHELYKVTLLPNQTHYVVPKGECLPYFSFAEIAKKGIEGAYSDNPIIRHASIANKWKTIHLLMHSGMNATTIHFNLTLQGKNDEEFKIQIVVEVDTREEPKRNSTTQKAYQSSMSSTTLLPEAEILFEDIPEEKRFPKVKRHDVNTTRRFQVEVEIPQVNISLLPKETQLSLNNLDLQLERGDITMKGYNLSKSALLRSFLMNPQNGKLTVNHPLTTEQRNGGLEAPLAKDAHKSNLGTSERRQGSSPVPAVTMTVNNHSQSQIPPLEARFRAITVTPKVGGRTVSREKLSSLTFPLESKDTQEKVITGKEQEKKIEENANSYPGGNEVVPGRKLQQYTDSYLGFLPWEKKKYFQDLLDEEESLKTQLAYFTDSKHTGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNISQVFDEVDTDQSGILSDREIRTLATRIHDLPLSLQDLTGLEHMLINCSKMLPANITQLNNIPPTQEAYYDPNLPPVTKSLVTNCKPVTDKIHKAFKDKNKYRFEIMGEEEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAVLRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAYRDKLKFWTHCVLATLIMFTVFSFFAEQLIALKRKIFPRRRIHKEASPDRIRV", "length": 1211, "header": "tr|A0A3Q1LVS0-1|F1MPB1_BOVIN Computationally mapped isoform of N-acetylglucosamine-1-phosphotransferase subunits alpha/beta OS=Bos taurus OX=9913 GN=GNPTAB PE=3 SV=2 CANONICAL=F1MPB1-1" }, "locus": { "chromosome": "5", "start_pos": 65643446, "end_pos": 65573537, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086179.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086179.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061272.2", "url": "https://www.ensembl.org/id/ENSBTAP00000061272.2" } ] } }, { "isoform_ac": "A0A3Q1M570-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M570/entry", "sequence": { "sequence": "MLLKLLQRQTYTCLSHRYGLYVCFVGVVVTIVSAFQFGEVVLEWSRDQYHVLFDSYRDNIAGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREQMEEEQKAMREILGKNTTEPTKKSEKPLECLLTHCIKVPMLVLDPALPTNVTLKDLPSLYPSFHSASDVFNVAKPKNPSTNVSVVVFDTTKSVEDAQAGMFKGNSRQTVWRGYLTTDKEVPGLVLMQDLAFLSGFPPTFKETNQLKAKLPENLSSKIKLLQLYSEASVALLKLNNPKDFQELNKQTKKNMTINGKELTISPAYLLWDLSAISQSKQDEDVSASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCSGNSGASRYIAGAGGTGSIGVGQPWHFGAGMTGVSYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQDHFHELYKVTLLPNQTHYVVPKGECLPYFSFAEIAKKGIEGAYSDNPIIRHASIANKWKTIHLLMHSGMNATTIHFNLTLQGKNDEEFKIQIVVEVDTREEPKRNSTTQKAYQSSMSSTTLLPEAEILFEDIPEEKRFPKVKRHDVNTTRRFQVEVEIPQVNISLLPKETQLSLNNLDLQLERGDITMKGYNLSKSALLRSFLMNPQNGKLTVNHPLTTEQRNGGLEAPLAKDAHKSNLGTSERRQGSSPVPAVTMTVNNHSQSQIPPLEARFRAITVTPKVGGRTVSREKLSSLTFPLESKDTQEKVITGKEQEKKIEENANSYPGGNEVVPGRKLQQYTDSYLGFLPWEKKKYFQDLLDEEESLKTQLAYFTDSKHTGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNISQVFDEVDTDQSGILSDREIRTLATRIHDLPLSLQPPVTKSLVTNCKPVTDKIHKAFKDKNKYRFEIMGEEEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAVLRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAYRDKLKFWTHCVLATLIMFTVFSFFAEQLIALKRKIFPRRRIHKEASPDRIRV", "length": 1211, "header": "tr|A0A3Q1M570-1|F1MPB1_BOVIN Computationally mapped isoform of N-acetylglucosamine-1-phosphotransferase subunits alpha/beta OS=Bos taurus OX=9913 GN=GNPTAB PE=3 SV=1 CANONICAL=F1MPB1-1" }, "locus": { "chromosome": "5", "start_pos": 65655828, "end_pos": 65573537, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074108.2", "url": "https://www.ensembl.org/id/ENSBTAT00000074108.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063430.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063430.1" } ] } }, { "isoform_ac": "A0AAA9T293-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T293/entry", "sequence": { "sequence": "MLLKLLQRQTYTCLSHRYGLYVCFVGVVVTIVSAFQFGEVVLEWSRDQYHVLFDSYRDNIAGKSFQNRSVR", "length": 71, "header": "tr|A0AAA9T293-1|F1MPB1_BOVIN Computationally mapped isoform of N-acetylglucosamine-1-phosphotransferase subunits alpha/beta OS=Bos taurus OX=9913 GN=GNPTAB PE=3 SV=1 CANONICAL=F1MPB1-1" }, "locus": { "chromosome": "5", "start_pos": 65655828, "end_pos": 65623580, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118381.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118381.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090536.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090536.1" } ] } }, { "isoform_ac": "A0AAA9T8L7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8L7/entry", "sequence": { "sequence": "MRPLVGLTQPALLSLVVLEWSRDQYHVLFDSYRDNIAGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREQMEEEQKAMREILGKNTTEPTKKSEKPLECLLTHCIKVPMLVLDPALPTNVTLKDLPSLYPSFHSASDVFNVAKPKNPSTNVSVVVFDTTKSVEDAQAGMFKGNSRQTVWRGYLTTDKEVPGLVLMQDLAFLSGFPPTFKETNQLKAKLPENLSSKIKLLQLYSEASVALLKLNNPKDFQELNKQTKKNMTINGKELTISPAYLLWDLSAISQSKQDEDVSASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCSGNSGASRYIAGAGGTGSIGVGQPWHFGAGMTGVSYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQDHFHELYKVTLLPNQTHYVVPKGECLPYFSFAEIAKKGIEGAYSDNPIIRHASIANKWKTIHLLMHSGMNATTIHFNLTLQGKNDEEFKIQIVVEVDTREEPKRNSTTQKAYQSSMSSTTLLPEAEILFEDIPEEKRFPKVKRHDVNTTRRFQVEVEIPQVNISLLPKETQLSLNNLDLQLERGDITMKGYNLSKSALLRSFLMNPQNGKLTVNHPLTTEQRNGGLEAPLAKDAHKSNLGTSERRQGSSPVPAVTMTVNNHSQSQIPPLEARFRAITVTPKVGGRTVSREKLSSLTFPLESKDTQEKVITGKEQEKKIEENANSYPGGNEVVPGRKLQQYTDSYLGFLPWEKKKYFQDLLDEEESLKTQLAYFTDSKHTGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNISQVFDEVDTDQSGILSDREIRTLATRIHDLPLSLQDLTGLEHMLINCSKMLPANITQLNNIPPTQEAYYDPNLPPVTKSLVTNCKPVTDKIHKAFKDKNKYRFEIMGEEEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAVLRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAYRDKLKFWTHCVLATLIMFTVFSFFAEQLIALKRKIFPRRRIHKEASPDRIRV", "length": 1225, "header": "tr|A0AAA9T8L7-1|F1MPB1_BOVIN Computationally mapped isoform of N-acetylglucosamine-1-phosphotransferase subunits alpha/beta OS=Bos taurus OX=9913 GN=GNPTAB PE=3 SV=1 CANONICAL=F1MPB1-1" }, "locus": { "chromosome": "5", "start_pos": 65643672, "end_pos": 65573537, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000111374.1", "url": "https://www.ensembl.org/id/ENSBTAT00000111374.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094305.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094305.1" } ] } }, { "isoform_ac": "F1MPB1-1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1/entry", "sequence": { "sequence": "MLLKLLQRQTYTCLSHRYGLYVCFVGVVVTIVSAFQFGEVVLEWSRDQYHVLFDSYRDNIAGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREQMEEEQKAMREILGKNTTEPTKKSEKPLECLLTHCIKVPMLVLDPALPTNVTLKDLPSLYPSFHSASDVFNVAKPKNPSTNVSVVVFDTTKSVEDAQAGMFKGNSRQTVWRGYLTTDKEVPGLVLMQDLAFLSGFPPTFKETNQLKAKLPENLSSKIKLLQLYSEASVALLKLNNPKDFQELNKQTKKNMTINGKELTISPAYLLWDLSAISQSKQDEDVSASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCSGNSGASRYIAGAGGTGSIGVGQPWHFGAGMTGVSYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQVMFVFFPLDHFHELYKVTLLPNQTHYVVPKGECLPYFSFAEIAKKGIEGAYSDNPIIRHASIANKWKTIHLLMHSGMNATTIHFNLTLQGKNDEEFKIQIVVEVDTREEPKRNSTTQKAYQSSMSSTTLLPEAEILFEDIPEEKRFPKVKRHDVNTTRRFQVEVEIPQVNISLLPKETQLSLNNLDLQLERGDITMKGYNLSKSALLRSFLMNPQNGKLTVNHPLTTEQRNGGLEAPLAKDAHKSNLGTSERRQGSSPVPAVTMTVNNHSQSQIPPLEARFRAITVTPKVGGRTVSREKLSSLTFPLESKDTQEKVITGKEQEKKIEENANSYPGGNEVVPGRKLQQYTDSYLGFLPWEKKKYFQDLLDEEESLKTQLAYFTDSKHTGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNISQVFDEVDTDQSGILSDREIRTLATRIHDLPLSLQDLTGLEHMLINCSKMLPANITQLNNIPPTQEAYYDPNLPPVTKSLVTNCKPVTDKIHKAFKDKNKYRFEIMGEEEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNHKDAQTVKAVLRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAYRDKLKFWTHCVLATLIMFTVFSFFAEQLIALKRKIFPRRRIHKEASPDRIRV", "length": 1257, "header": "tr|F1MPB1-1|F1MPB1_BOVIN Isoform 1 of N-acetylglucosamine-1-phosphotransferase subunits alpha/beta OS=Bos taurus OX=9913 GN=GNPTAB PE=3 SV=3 CANONICAL=F1MPB1-1" }, "locus": { "chromosome": "5", "start_pos": 65655828, "end_pos": 65573537, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025859.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025859.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025859.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025859.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity", "id": "GO:0003976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003976", "evidence": [ { "database": "UniProtKB", "id": "F1MPB1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MPB1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1" } ], "pmid": "" }, { "name": "transferase activity", "id": "GO:0016740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740", "evidence": [ { "database": "UniProtKB", "id": "F1MPB1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F1MPB1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1MPB1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1MPB1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1" } ], "pmid": "" }, { "name": "establishment of localization in cell", "id": "GO:0051649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051649", "evidence": [ { "database": "UniProtKB", "id": "F1MPB1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1" } ], "pmid": "" }, { "name": "carbohydrate phosphorylation", "id": "GO:0046835", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046835", "evidence": [ { "database": "UniProtKB", "id": "F1MPB1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1" } ], "pmid": "" }, { "name": "lysosome organization", "id": "GO:0007040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007040", "evidence": [ { "database": "UniProtKB", "id": "F1MPB1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1" } ], "pmid": "" }, { "name": "N-glycan processing to lysosome", "id": "GO:0016256", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016256", "evidence": [ { "database": "UniProtKB", "id": "F1MPB1", "url": "https://www.uniprot.org/uniprotkb/F1MPB1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1010, "end_pos": 1012, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1057, "end_pos": 1059, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1065, "end_pos": 1067, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1130, "end_pos": 1132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 114, "end_pos": 116, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 179, "end_pos": 181, "annotation": "n_glycosylation_sequon" }, { "start_pos": 250, "end_pos": 252, "annotation": "n_glycosylation_sequon" }, { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 376, "end_pos": 378, "annotation": "n_glycosylation_sequon" }, { "start_pos": 457, "end_pos": 459, "annotation": "n_glycosylation_sequon" }, { "start_pos": 559, "end_pos": 561, "annotation": "n_glycosylation_sequon" }, { "start_pos": 615, "end_pos": 617, "annotation": "n_glycosylation_sequon" }, { "start_pos": 622, "end_pos": 624, "annotation": "n_glycosylation_sequon" }, { "start_pos": 650, "end_pos": 652, "annotation": "n_glycosylation_sequon" }, { "start_pos": 692, "end_pos": 694, "annotation": "n_glycosylation_sequon" }, { "start_pos": 707, "end_pos": 709, "annotation": "n_glycosylation_sequon" }, { "start_pos": 737, "end_pos": 739, "annotation": "n_glycosylation_sequon" }, { "start_pos": 805, "end_pos": 807, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], 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"id": "F1MPB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPB1" } ] }, { "ec_number": "2.7.8.17", "activity": "", "evidence": [ { "id": "F1MPB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPB1" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MPB1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1257, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MPB1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MPB1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MPB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPB1" }, { "id": "PS51912", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51912" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DMAP1-binding", "eco_id": "ECO_0000259", "start_pos": 707, "end_pos": 809, "start_aa": "Asn", 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"N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP + H(+).", "evidence": [ { "id": "2.7.8.17", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.17" }, { "id": "2.7.8.17", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.8.17" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1010, "end_pos": 1012 }, { "start_pos": 1057, "end_pos": 1059 }, { "start_pos": 1065, "end_pos": 1067 }, { "start_pos": 1130, "end_pos": 1132 }, { "start_pos": 114, "end_pos": 116 }, { "start_pos": 148, "end_pos": 150 }, { "start_pos": 179, 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF02463", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002689686", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689686", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMB6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMB6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMB6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPW4", "url": "https://www.uniprot.org/uniprotkb/F1MPW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPW4-1", "url": "https://www.uniprot.org/uniprotkb/F1MPW4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"length": 1089, "header": "tr|A0A3Q1LMB6-1|F1MPW4_BOVIN Computationally mapped isoform of Structural maintenance of chromosomes protein 5 OS=Bos taurus OX=9913 GN=SMC5 PE=3 SV=2 CANONICAL=F1MPW4-1" }, "locus": { "chromosome": "8", "start_pos": 46527176, "end_pos": 46411542, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079499.3", "url": "https://www.ensembl.org/id/ENSBTAT00000079499.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057777.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057777.2" } ] } }, { "isoform_ac": "F1MPW4-1", "url": "https://www.uniprot.org/uniprotkb/F1MPW4/entry", "sequence": { "sequence": "MATPSRRTSTQSPLASKRAILSDPSSEVPSKKKSSVPPAAPRPLPSSGPFVEGSIVRIAMENFLTYDVCEVSPGPHLNMIIGANGTGKSSIVCAICLGLAGKPAFMGRADKVGFFVKRGCSKGMVEIELFRTSGNLVITREIDVAKNQSSWFINKKSTSPKVVEEQVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSVGPPEMHKYHCELKNFREKEKQLETSCKQKTEYLEKMIQRNERYKQDVDRFYERKRHLDLIEMLEAKRPWVEYENVRQEYEEVKLARDQAKEEVRKLKESQIPITERIEEMERQRHSLEARIREKALAIKETSQKCKHKQDVIERKDKQIEELQQALTVKQNEEHDRQRRISNTRKMIEDLQNELRTTENCENLQPQIDAITNDLRRVQDEKALCESEIIDKRKERETLEKEKRSVDDHIVRFDNLMNQKEDKLRQRYRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSNDLRAFVFENQEDMEVFLKEVRDNKKLRVNAVIAPKNSYADKAPSRSLNDLKQYGFFSYLRELFDAPDPVMSYLCCQYHIHEVPVGTERTREKIERVIQETRLKQIYTAEEKYVVKTSFYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEINRKLQAVDSGLIALHETNKHLEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIKEINIQKAKLVTELTNLIKNCTALHIQKVDLILQNTTVISEKNKLESDYMATSAQLRITEQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTVPQEYQTQVPTIPNGHNSSPPMAFQDLPNTLDEIDALLTEERSRASCFTGLNPTVVEEYTKREEEIEQLTAELKIKKVELDKYRENISQVKERWLNPLKELVEKINEKFSYFFSSMQCAGEVDLHTENEEDYDKYGIRIRVKFRSSTELHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINERRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFVYNGPHMLEPNRWNLKAFQRRRRRITFTQPSQ", "length": 1104, "header": "tr|F1MPW4-1|F1MPW4_BOVIN Isoform 1 of Structural maintenance of chromosomes protein 5 OS=Bos taurus OX=9913 GN=SMC5 PE=3 SV=4 CANONICAL=F1MPW4-1" }, "locus": { "chromosome": "8", "start_pos": 46527176, "end_pos": 46411542, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061396.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061396.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053371.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053371.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3, "start_aa": "Thr", "end_pos": 3, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:508938", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:508938", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nuclear lumen", "id": "GO:0031981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031981", "evidence": [ { "database": "UniProtKB", "id": "F1MPW4", "url": "https://www.uniprot.org/uniprotkb/F1MPW4" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "F1MPW4", "url": "https://www.uniprot.org/uniprotkb/F1MPW4" } ], "pmid": "" }, { "name": "PML body", "id": "GO:0016605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016605", "evidence": [ { "database": "UniProtKB", "id": "F1MPW4", "url": "https://www.uniprot.org/uniprotkb/F1MPW4" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "F1MPW4", "url": "https://www.uniprot.org/uniprotkb/F1MPW4" } ], "pmid": "" }, { "name": "Smc5-Smc6 complex", "id": "GO:0030915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030915", "evidence": [ { "database": "UniProtKB", "id": "F1MPW4", "url": "https://www.uniprot.org/uniprotkb/F1MPW4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MPW4", "url": "https://www.uniprot.org/uniprotkb/F1MPW4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "F1MPW4", "url": "https://www.uniprot.org/uniprotkb/F1MPW4" } ], "pmid": "" }, { "name": "DNA recombination", "id": "GO:0006310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006310", "evidence": [ { "database": "UniProtKB", "id": "F1MPW4", "url": "https://www.uniprot.org/uniprotkb/F1MPW4" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "F1MPW4", "url": "https://www.uniprot.org/uniprotkb/F1MPW4" } ], "pmid": "" }, { "name": "chromosome organization", "id": "GO:0051276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051276", "evidence": [ { "database": "UniProtKB", "id": "F1MPW4", "url": "https://www.uniprot.org/uniprotkb/F1MPW4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1047, "end_pos": 1049, "annotation": "n_glycosylation_sequon" }, { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 636, "end_pos": 638, "annotation": "n_glycosylation_sequon" }, { "start_pos": 761, "end_pos": 763, "annotation": "n_glycosylation_sequon" }, { "start_pos": 776, "end_pos": 778, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" }, { "start_pos": 853, "end_pos": 855, "annotation": "n_glycosylation_sequon" }, { "start_pos": 922, "end_pos": 924, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MPW4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1104, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MPW4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MPW4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MPW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPW4" }, { "id": "PF02463", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02463" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RecF/RecN/SMC N-terminal", "eco_id": "ECO_0000259", "start_pos": 55, "end_pos": 1055, "start_aa": "Ile", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 3 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1047, "end_pos": 1049 }, { "start_pos": 147, "end_pos": 149 }, { "start_pos": 636, "end_pos": 638 }, { "start_pos": 761, "end_pos": 763 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"field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMY9-1", "uniprot_ac": "F1MMY9", "uniprot_id": "F1MMY9_BOVIN", "mass": { "chemical_mass": 67068.0, "monoisotopic_mass": 67068.0 }, "refseq": {}, "gene_names": [ { "name": "PIAS2", "type": "recommended", "evidence": [ { "id": "F1MMY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMY9" } ] } ], "protein_names": [ { "name": "Protein inhibitor of activated STAT 2", "type": "synonym", "evidence": [ { "id": "F1MMY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMY9/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMY9", "url": "https://www.uniprot.org/uniprotkb/F1MMY9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PIAS2", "url": "https://www.uniprot.org/uniprotkb/F1MMY9", "locus": { "chromosome": "24", "start_pos": 46528373, "end_pos": 46645305, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007833", "url": "https://www.ensembl.org/id/ENSBTAG00000007833" } ] } } ], "crossref": [ { "id": "F1MMY9", "url": "https://alphafold.ebi.ac.uk/entry/F1MMY9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007833", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007833", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16819", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16819", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "533403", "url": "https://www.ncbi.nlm.nih.gov/gene/533403", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023321", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023321", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036361", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036361", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038654", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038654", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:533403", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533403", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DPQQYCP", "url": "https://omabrowser.org/oma/group/DPQQYCP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPE8", "url": "https://www.orthodb.org/?gene=A0A3Q1LPE8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LW44", "url": "https://www.orthodb.org/?gene=A0A3Q1LW44", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M3X8", "url": "https://www.orthodb.org/?gene=A0A3Q1M3X8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MBF1", "url": "https://www.orthodb.org/?gene=A0A3Q1MBF1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MMY9", "url": "https://www.orthodb.org/?gene=F1MMY9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10782", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10782", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10782:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10782:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02037", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02037", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02891", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02891", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14324", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14324", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3108214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3108214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3232118", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3232142", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3232142", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-3899300", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3899300", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4090294", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4090294", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4551638", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4551638", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LPE8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPE8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPE8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LW44", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW44", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LW44-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW44-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3X8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M3X8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3X8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBF1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MBF1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMY9", "url": "https://www.uniprot.org/uniprotkb/F1MMY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMY9-1", "url": "https://www.uniprot.org/uniprotkb/F1MMY9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSAIKSPVFSLDGSSSPVEPDLAVAGIHALPSTSVTPHSPSSPVGSVLLQDTKPAFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCTDVDEIKFQEDGSWCPMRPKKEAMKVSTQPCPKIETSTVLSKPCAVTVASEPSKKKVDVIDLTVESSSDEEEGPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPISSMSSDLPGLDFLSLIPVDPQYCPPMFLDSLTSPLTASSASVTTTSPHESSTHVSSSSSRSETGVITSSGSNIPDIISLD", "length": 612, "header": "tr|F1MMY9-1|F1MMY9_BOVIN Isoform 1 of Protein inhibitor of activated STAT 2 OS=Bos taurus OX=9913 GN=PIAS2 PE=3 SV=4 CANONICAL=F1MMY9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPE8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPE8/entry", "sequence": { "sequence": "MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSAIKSPVFSLDGSSSPVEPDLAVAGIHALPSTSVTPHSPSSPVGSVLLQDTKPAFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCTDVDEIKFQEDGSWCPMRPKKEAMKVSTQPCPKIETSTVLSKPCAVTVASEPSKKKVDVIDLTVESSSDEEEGPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPISSMSSDLPGLDFLSLIPVDPQAPFWPF", "length": 568, "header": "tr|A0A3Q1LPE8-1|F1MMY9_BOVIN Computationally mapped isoform of Protein inhibitor of activated STAT 2 OS=Bos taurus OX=9913 GN=PIAS2 PE=3 SV=2 CANONICAL=F1MMY9-1" }, "locus": { "chromosome": "24", "start_pos": 46645095, "end_pos": 46528437, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082444.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082444.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058797.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058797.2" } ] } }, { "isoform_ac": "A0A3Q1LW44-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LW44/entry", "sequence": { "sequence": "MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSAIKSPVFSLDGSSSPVEPDLAVAGIHALPSTSVTPHSPSSPVGSVLLQDTKPAFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCTDVDEIKFQEDGSWCPMRPKKEAMKVSTQPCPKIETSTVLSKPCAVTVASEPSKKKVDVIDLTVESSSDEEEGPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPISSMSSDLPGLDFLSLIPVDPQQYCPPMFLDSLTSPLTASSASVTTTSPHESSTHVSSSSSRSETGVITSSGSNIPDIISLD", "length": 622, "header": "tr|A0A3Q1LW44-1|F1MMY9_BOVIN Computationally mapped isoform of Protein inhibitor of activated STAT 2 OS=Bos taurus OX=9913 GN=PIAS2 PE=3 SV=2 CANONICAL=F1MMY9-1" }, "locus": { "chromosome": "24", "start_pos": 46645095, "end_pos": 46532662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069671.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069671.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059600.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059600.2" } ] } }, { "isoform_ac": "A0A3Q1M3X8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M3X8/entry", "sequence": { "sequence": "MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSAIKSPVFSLDGSSSPVEPDLAVAGIHALPSTSVTPHSPSSPVGSVLLQDTKPAFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCTDVDEIKFQEDGSWCPMRPKKEAMKVSTQPCPKIETSTVLSKPCAVTVASEPSKKKVDVIDLTVESSSDEEEGPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPISSMSSDLPGEQRRNDINNELQLGTSSDTVQQ", "length": 572, "header": "tr|A0A3Q1M3X8-1|F1MMY9_BOVIN Computationally mapped isoform of Protein inhibitor of activated STAT 2 OS=Bos taurus OX=9913 GN=PIAS2 PE=3 SV=2 CANONICAL=F1MMY9-1" }, "locus": { "chromosome": "24", "start_pos": 46645095, "end_pos": 46537113, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068180.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068180.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064889.2", "url": "https://www.ensembl.org/id/ENSBTAP00000064889.2" } ] } }, { "isoform_ac": "A0A3Q1MBF1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MBF1/entry", "sequence": { "sequence": "MPQNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSAIKSPVFSLDGSSSPVEPDLAVAGIHALPSTSVTPHSPSSPVGSVLLQDTKPAFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCTDVDEIKFQEDGSWCPMRPKKEAMKVSTQPCPKIETSTVLSKPCAVTVASEPSKKKVDVIDLTVESSSDEEEGPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPISSMSSDLPGLDFLSLIPVDPQYCPPMFLDSLTSPLTASSASVTTTSPHESSTHVSSSSSRSETGVITSSGSNIPDIISLD", "length": 616, "header": "tr|A0A3Q1MBF1-1|F1MMY9_BOVIN Computationally mapped isoform of Protein inhibitor of activated STAT 2 OS=Bos taurus OX=9913 GN=PIAS2 PE=3 SV=2 CANONICAL=F1MMY9-1" }, "locus": { "chromosome": "24", "start_pos": 46625288, "end_pos": 46532662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069001.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069001.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067606.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067606.2" } ] } }, { "isoform_ac": "F1MMY9-1", "url": "https://www.uniprot.org/uniprotkb/F1MMY9/entry", "sequence": { "sequence": "MVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSAIKSPVFSLDGSSSPVEPDLAVAGIHALPSTSVTPHSPSSPVGSVLLQDTKPAFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCTDVDEIKFQEDGSWCPMRPKKEAMKVSTQPCPKIETSTVLSKPCAVTVASEPSKKKVDVIDLTVESSSDEEEGPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPISSMSSDLPGLDFLSLIPVDPQYCPPMFLDSLTSPLTASSASVTTTSPHESSTHVSSSSSRSETGVITSSGSNIPDIISLD", "length": 612, "header": "tr|F1MMY9-1|F1MMY9_BOVIN Isoform 1 of Protein inhibitor of activated STAT 2 OS=Bos taurus OX=9913 GN=PIAS2 PE=3 SV=4 CANONICAL=F1MMY9-1" }, "locus": { "chromosome": "24", "start_pos": 46597795, "end_pos": 46532662, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010308.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010308.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010308.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010308.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 448, "start_aa": "Thr", "end_pos": 448, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr448", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:533403", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533403", "resource": "KEGG Pathway" }, { "id": "R-BTA-3108214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3108214", "resource": "Reactome", "description": "SUMOylation of DNA damage response and repair proteins" }, { "id": "R-BTA-3232118", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3232118", "resource": "Reactome", "description": "SUMOylation of transcription factors" }, { "id": "R-BTA-3232142", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3232142", "resource": "Reactome", "description": "SUMOylation of ubiquitinylation proteins" }, { "id": "R-BTA-3899300", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3899300", "resource": "Reactome", "description": "SUMOylation of transcription cofactors" }, { "id": "R-BTA-4090294", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4090294", "resource": "Reactome", "description": "SUMOylation of intracellular receptors" }, { "id": "R-BTA-4551638", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4551638", "resource": "Reactome", "description": "SUMOylation of chromatin organization proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M2BCP8-1", "protein_name": "E3 SUMO-protein ligase PIAS2 isoform X1", "gene_name": "pias2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MADIEELRNMVSSFRVSELQVLLGFAGRNKSGRKHELLLRALHLLRSGCSSAVQIKIKELYRRRYPRTFEGLQDLAALKSSIKSFIHLDSGATAVSSDLTLPTDHSDVLQQRRESCDSPVFHESKPMMNMQQPTTLMAPVHPDVQMKSLPFYDVLDVLIKPSSLGAHAVQRFHNEKYFIFALTPQQVREVCISRDFLPGGRRDYMVQIQLRFCLAETSCPQEDNYPNGLCIKVNGKLFPLPGFAPPPKNGVEQKRPGRPLNITSLVRLSSAVPNQIVVTWAPEIGKTYSMSVYLVRQLTSPLLLQRLRMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTVPCRAVTCSHLQCFDAALYLQMNEKKPTWICPVCDKKATYESLIIDGLFMEILNDCTDVDEIQFQEDGTWCPMRPKKETLKLSSPCISKIDCSVPVRQSAVVSVPETSSTKKADVIDLTLESSSDDEEDDPPLKKRCIYMSKAEEMHSKGVLTYQPSTVRVPNVQSLDTSYLTSSIADYSVPFHHSSLSTIPTDMQSLDLFSLIQGDPQQHFRGPIFLDSLSSSLQSATTSASLVSSSAQYETATHSSSSSHETGVITGGSSGLSDIISLD", "length": 624 }, "evidence": [ { "id": "F1MMY9", "url": "https://omabrowser.org/oma/group/F1MMY9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "O75928-1", "protein_name": "E3 SUMO-protein ligase PIAS2", "gene_name": "PIAS2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLCDLSTIKSSVFSLDGSSSPVEPDLPVAGIHSLPSTSITPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVTSQPCTKVESSSVFSKPCSVTVASDASKKKIDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPVSSMSSDLPGLDFLSLIPVDPQYCPPMFLDSLTSPLTASSTSVTTTSPHESSTHVSSSSSRSETGVITSSGRNIPDIISLD", "length": 621 }, "evidence": [ { "id": "F1MMY9", "url": "https://omabrowser.org/oma/group/F1MMY9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "SUMO ligase activity", "id": "GO:0061665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061665", "evidence": [ { "database": "UniProtKB", "id": "F1MMY9", "url": "https://www.uniprot.org/uniprotkb/F1MMY9" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MMY9", "url": "https://www.uniprot.org/uniprotkb/F1MMY9" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "F1MMY9", "url": "https://www.uniprot.org/uniprotkb/F1MMY9" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MMY9", "url": "https://www.uniprot.org/uniprotkb/F1MMY9" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "F1MMY9", "url": "https://www.uniprot.org/uniprotkb/F1MMY9" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "F1MMY9", "url": "https://www.uniprot.org/uniprotkb/F1MMY9" } ], "pmid": "" }, { "name": "transferase activity", "id": "GO:0016740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740", "evidence": [ { "database": "UniProtKB", "id": "F1MMY9", "url": "https://www.uniprot.org/uniprotkb/F1MMY9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MMY9", "url": "https://www.uniprot.org/uniprotkb/F1MMY9" } ], "pmid": "" }, { 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Peptide", "id": "ENSBTAP00000056888.3", "url": "https://www.ensembl.org/id/ENSBTAP00000056888.3" } ] } }, { "isoform_ac": "F1MQ90-1", "url": "https://www.uniprot.org/uniprotkb/F1MQ90/entry", "sequence": { "sequence": "MSWGIELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYRYTACQAFLATLNEMNDYAGQHELISENMTSQIIVELVRYVQELKQERKSHFHDGRKAQQHIEMCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQTRHQMAEDSKTDYSSILQKFNHEQHEYYHTHVPNIFQKIQEMEERRIVRIGESVKTYAELDRQVIPIIGKCLDGIVKAAESIDPKNDSQLVVEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKSELKFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGATPEDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPTSLDHKLAEVSQNIDKLRLETQKFEAWLAEVEGRLPARSDQARRQSGMYEAQNAPSVNNCAQDRESPDGSYTEEQSQESEVKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTSYVEVYLDKNAKDC", "length": 617, "header": "tr|F1MQ90-1|F1MQ90_BOVIN Isoform 1 of Formin binding protein 1 OS=Bos taurus OX=9913 GN=FNBP1 PE=3 SV=4 CANONICAL=F1MQ90-1" }, "locus": { "chromosome": "11", "start_pos": 100399646, "end_pos": 100267357, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027072.7", "url": "https://www.ensembl.org/id/ENSBTAT00000027072.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027072.7", "url": "https://www.ensembl.org/id/ENSBTAP00000027072.7" } ] } }, { "isoform_ac": "G5E6K6-1", "url": "https://www.uniprot.org/uniprotkb/G5E6K6/entry", "sequence": { "sequence": "MSWGIELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYRYTACQAFLATLNEMNDYAGQHELISENMTSQIIVELVRYVQELKQERKSHFHDGRKAQQHIEMCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQTRHQMAEDSKTDYSSILQKFNHEQHEYYHTHVPNIFQKIQEMEERRIVRIGESVKTYAELDRQVIPIIGKCLDGIVKAAESIDPKNDSQLVVEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKSELKFGGKSKGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGTQALCFHKELMKRTIGKPTYAFEARDYVLSLKLGATPEDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMKDVYLKNPQMGDPTSLDHKLAEVSQNIDKLRLETQKFEAWLAEVEGRLPARSDQARRQSGMYEAQNAPSVNNCAQDRESPDGSYTEEQSQESEVKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTSYVEVYLDKNAKDC", "length": 645, "header": "tr|G5E6K6-1|F1MQ90_BOVIN Computationally mapped isoform of Formin binding protein 1 OS=Bos taurus OX=9913 GN=FNBP1 PE=3 SV=3 CANONICAL=F1MQ90-1" }, "locus": { "chromosome": "11", "start_pos": 100399646, "end_pos": 100267357, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000064823.3", 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"synonym", "evidence": [ { "id": "XP_024833333", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833333" } ] } ], "protein_names": [ { "name": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase", "type": "recommended", "evidence": [ { "id": "F1MNJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNJ3/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.66", "type": "synonym", "evidence": [ { "id": "F1MNJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNJ3/entry#names_and_taxonomy" } ] }, { "name": "inositol polyphosphate 4-phosphatase type II isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024833333", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833333" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MNJ3", "url": "https://www.uniprot.org/uniprotkb/F1MNJ3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "INPP4B", "url": "https://www.uniprot.org/uniprotkb/F1MNJ3", "locus": { "chromosome": "17", "start_pos": 15825213, "end_pos": 15122383, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014111", "url": "https://www.ensembl.org/id/ENSBTAG00000014111" } ] } } ], "crossref": [ { "id": "F1MNJ3", "url": "https://alphafold.ebi.ac.uk/entry/F1MNJ3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014111", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014111", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04048", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04048", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "534793", "url": "https://www.ncbi.nlm.nih.gov/gene/534793", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:534793", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534793", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CSHRMAQ", "url": "https://omabrowser.org/oma/group/CSHRMAQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LSR1", "url": "https://www.orthodb.org/?gene=A0A3Q1LSR1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MNJ3", "url": "https://www.orthodb.org/?gene=F1MNJ3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12187", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12187", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12187:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12187:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27561", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27561", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1660499", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660499", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1660516", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660516", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1855183", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855183", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024833333", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833333", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "43388", "url": "https://www.rhea-db.org/rhea/43388", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LSR1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSR1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LSR1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSR1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TZB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZB2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNJ3", "url": "https://www.uniprot.org/uniprotkb/F1MNJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNJ3-1", "url": "https://www.uniprot.org/uniprotkb/F1MNJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEIKEEGASEEGQNFLPTPQANDTGDFQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPAEQGLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVVPEHKDPPPEVGRSFLGYASFKVGELLKSKEQVLALSLRTSDGGKVVGTIEVSVVKMGEIEDGEADNITTDVQGQKCALVCECSAPESVSRKDNLPFLNAVLKNPVCKLYRFPTSDNKWMQIREQMSESILSFHIPKELISLQIKEDLCRNQELKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMHVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFEAERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIAAHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGVLKKPPSPQSGTEESISQDPPLPVRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERESGGEGSSTSSKDVEKDSSPVDSIITHPKEDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLYDPGFLEQLHTVGLIVQYEGLLSTYSEEIGMLEDMAVGISDLKKVAFKIIEATSNDVLPVITGRREHYVVEVKVPARVFESLPLQIKEGQLLHVHPVLFNVGINEQQTLAERFGDVSLQESINQENFELLKEYYTVFMEKMPPDYISHFQEQNDLKGLLENLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT", "length": 925, "header": "tr|F1MNJ3-1|F1MNJ3_BOVIN Isoform 1 of phosphatidylinositol-3,4-bisphosphate 4-phosphatase OS=Bos taurus OX=9913 GN=INPP4B PE=3 SV=2 CANONICAL=F1MNJ3-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LSR1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LSR1/entry", "sequence": { "sequence": "MEIKEEGASEEGQNFLPTPQANDTGDFQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPAEQGLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVVPEHKDPPPEVGRSFLGYASFKVGELLKSKEQVLALSLRTSDGGKVVGTIEVSVVKMGEIEDGEADNITTDVQGQKCALVCECSAPESVSRKDNLPFLNAVLKNPVCKLYRFPTSDNKWMQIREQMSESILSFHIPKELISLQIKEDLCRNQELKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMHVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFEAERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIAAHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGVLKKPPSPQSGTEESISQDPPLPVRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERESGGEGSSTSSKDVEKDSSPVDSIITHPKEDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLYDPGFLEQLHTVGLIVQYEGLLSTYSEEIGMLEDMAVGISDLKKVAFKIIEATSNDVLPVITGRREHYVVEVKVPARVFESLPLQIKEGQLLHVHPVLFNVGINEQQTLAERFGDVSLQESINQENFELLKEYYTVFMEKMPPDYISHFQEQNDLKGLLENLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRSRQTQGALNESDDPETGCLTDNKPTSRHFYPVALLLVSSHLLVVWLILSLALLLAKYQ", "length": 939, "header": "tr|A0A3Q1LSR1-1|F1MNJ3_BOVIN Computationally mapped isoform of phosphatidylinositol-3,4-bisphosphate 4-phosphatase OS=Bos taurus OX=9913 GN=INPP4B PE=3 SV=1 CANONICAL=F1MNJ3-1" }, "locus": { "chromosome": "17", "start_pos": 15822817, "end_pos": 15401418, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079052.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079052.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063433.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063433.1" } ] } }, { "isoform_ac": "A0AAA9TZB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TZB2/entry", "sequence": { "sequence": "MEIKEEGASEEGQNFLPTPQANDTGDFQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPAEQGLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDT", "length": 124, "header": "tr|A0AAA9TZB2-1|F1MNJ3_BOVIN Computationally mapped isoform of phosphatidylinositol-3,4-bisphosphate 4-phosphatase OS=Bos taurus OX=9913 GN=INPP4B PE=3 SV=1 CANONICAL=F1MNJ3-1" }, "locus": { "chromosome": "17", "start_pos": 15438280, "end_pos": 15401418, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131269.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131269.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102587.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102587.1" } ] } }, { "isoform_ac": "F1MNJ3-1", "url": "https://www.uniprot.org/uniprotkb/F1MNJ3/entry", "sequence": { "sequence": "MEIKEEGASEEGQNFLPTPQANDTGDFQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPAEQGLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVVPEHKDPPPEVGRSFLGYASFKVGELLKSKEQVLALSLRTSDGGKVVGTIEVSVVKMGEIEDGEADNITTDVQGQKCALVCECSAPESVSRKDNLPFLNAVLKNPVCKLYRFPTSDNKWMQIREQMSESILSFHIPKELISLQIKEDLCRNQELKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMHVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFEAERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIAAHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGVLKKPPSPQSGTEESISQDPPLPVRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERESGGEGSSTSSKDVEKDSSPVDSIITHPKEDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLYDPGFLEQLHTVGLIVQYEGLLSTYSEEIGMLEDMAVGISDLKKVAFKIIEATSNDVLPVITGRREHYVVEVKVPARVFESLPLQIKEGQLLHVHPVLFNVGINEQQTLAERFGDVSLQESINQENFELLKEYYTVFMEKMPPDYISHFQEQNDLKGLLENLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT", "length": 925, "header": "tr|F1MNJ3-1|F1MNJ3_BOVIN Isoform 1 of phosphatidylinositol-3,4-bisphosphate 4-phosphatase OS=Bos taurus OX=9913 GN=INPP4B PE=3 SV=2 CANONICAL=F1MNJ3-1" }, "locus": { "chromosome": "17", "start_pos": 15824209, "end_pos": 15401418, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018761.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018761.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018761.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018761.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:534793", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:534793", "resource": "KEGG Pathway" }, { "id": "R-BTA-1660499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660499", "resource": "Reactome", "description": "Synthesis of PIPs at the plasma membrane" }, { "id": "R-BTA-1660516", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1660516", "resource": "Reactome", "description": "Synthesis of PIPs at the early endosome membrane" }, { "id": "R-BTA-1855183", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855183", "resource": "Reactome", "description": "Synthesis of IP2, IP, and Ins in the cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A1D5PYC2-1", "protein_name": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase", "gene_name": "INPP4B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEIKEERASDEAQQFLPSSQIDSLGEPQLTSIQRIANEPKLEFSLACKDLVAATRDRKLNTFIQVSVVHPAEHVLTRYSSTEIVEGTRDPLFLTGVTFPPEYPIYEETKIKLTVYDVKDKSQDTVHTTVLPDHKEPRTDVGRSFLGFTTFTVGDLVKSKEQQLTLTLRTSDGGKTVGTIEVNLVNMGELEDGEPGHVTTDSQDQKLLCFLPLKSCKRGFLSAASAHNTENLERMADRKAKEECALVRECTASEGISGKDNLPSLNAVLKNPICKLYRFPTSDNKWMRIREQMAETILSFHVPKELINLHIKEDMRRNQELKDLGELAPHWDNMRKSVIAHCDQMLSMYQDTLAELGKHTGSSFKSSCSKGEKTLEFIPINLHLQRMHVHSPLLKDALYDVITVGAPAAHFQGFKNGGLRKLLSKFETERRNTGYQCIYYSPENTAKAKEVLSNINHLQPLISSHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGCVLKKPAVPRNSAEEGDDLKHQDHPSQVKRQDSIPHHSEYDEEEWDRVWANVGKSLNCVIAMVDKLLEKDNSGNTKEGETDPSTADCKHAGSDWYEQLYPLVITLKDCMGEVVTRAKQSMAFVLLQELACGLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTGLHDQGFLQQLHTVGLLVQYEGLLSTYSEEAGMLEDMAVGISDLQKVMFKVIEAKSEDFLPIITGRREHYVIEVQLPAKMFELLPQEIKEGKLLRMYPVLFNVGINEQQTLADRFGDTTLQENINQENLQLLKEYYNLFTEKMPPDCLPHFQEQNDLKGLLESLHQSIQAKKRKNVEIMWLAATICRKLNGVRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRSRQTQGALNDSDDPETGCLTDNKPTSRHFYPVALLLVSSHLLVVWLILSLALLLAKYQ", "length": 972 }, "evidence": [ { "id": "F1MNJ3", "url": "https://omabrowser.org/oma/group/F1MNJ3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8C2MC16-1", "protein_name": "Type II inositol 3,4-bisphosphate 4-phosphatase", "gene_name": "Inpp4b", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEIKEEGTSEEGQHFLPTAQITDQEDTQFTSIQKIPNEPQLEFILACKDLVAPVCDRKLNTVVQISVIHPVEQTLTRYSSTEIVEGTKDPLFLTGVTFPPEYPIYEETRIKLTVYDVKDKSHDTIRTSVLLEHKDPPPEVGRSFLGSASFQVGELLKSKEQLLSLSLRTSDGGKVVGTIEVSLVKMGEIEDGDTDHITTVVQGQKCALAYECAAPDSVSGKDSLPLLNAVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQELKELGDLSPHWDNLRKNVLTHCDQMVTMYQDILTELSKETGSSFKSSSNKGEKTLEFVPINLHLQRMQVQSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLSSASQHSPDSLKSSLKLLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKDSAEKTSPQDEPPQLRRQDSIPHHSDYDEEEWDRVWANMGKSLNCIIATVDKLIERDGHNKEGGGGSSSQDGDMEASLEDSITSHPKEDWYEQLHPLIITLKECMGEVVSRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLHDPYFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLRKVAFKITEAKSSDDLPVLTGRREHYVVEVKLPATVFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYFSIFMEKMPPDYISHFQEQNDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRSRQTQGALNESDDPETGCLTDNKPTSRHFYPVALLLVSSHLLVVWLILSLALLLAKYQ", "length": 941 }, "evidence": [ { "id": "F1MNJ3", "url": "https://omabrowser.org/oma/group/F1MNJ3/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "F1RRG5-1", "protein_name": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase", "gene_name": "INPP4B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEIKEEGTSEEGQHFLPAPQANDTGDFQFTSIQKTPDEPQLEFILACKDLVAPVRDRKLNTLVQIAVVHPAEQSLTRYSCTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPLPEVGRSFLGYASFKVGELLKSKEQVLALSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSRKDNLPFLNAVLKNPVYKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLQIKEDLCRNQELKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKSLEFVPVNLHLQRMHVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTEYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQRSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGVLKKPPSPKNSTEESSSQDPPPPMRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGFSEGSSSSKDGEKDPSLVDSTITHPKEDWYEQLYPLILTLKDCMGEVVHRAKQSLTFVLLQELAYSLPQCLMLTLRRDVVFSQALAGLVCGFVIKLHTSLYDPGFLEQLHTVGLIAQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARLFESLPLQIKEGQLLRVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLKEYCTVFMEKMPPDYISHFQEQNDLKGLLENLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT", "length": 924 }, "evidence": [ { "id": "F1MNJ3", "url": "https://omabrowser.org/oma/group/F1MNJ3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O15327-1", "protein_name": "Inositol polyphosphate 4-phosphatase type II", "gene_name": "INPP4B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKEQLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT", "length": 924 }, "evidence": [ { "id": "F1MNJ3", "url": "https://omabrowser.org/oma/group/F1MNJ3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6P1Y8-1", "protein_name": "Type II inositol 3,4-bisphosphate 4-phosphatase", "gene_name": "Inpp4b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEIKEEGTSEEGQHFLPAAQANDPEDIQFTSIQKIPNEPQLEFILACRDLVAPVSDRKLNTVVQISVIHPVEQTLTRYSSTEIVEGTKDPLFLTGVTFPPDYPIYEETRIKLTVYDVKDKSHDTIRTSVLPEHKDPLPEVARSFLGCASFKVGELLKSKEQLLSLSLRTSDGGKVVGTIEVSLVKMGEIEDGDTDHITTDVQGQKCALMYESTAPESLSGKENLPFMNAVLRNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQELKELGDLSPHWDNLRKNVLSHCDQMVTMYQDILTELSKETGSSFKSSSSKGEKTLEFVPVNLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSSINQLQPLIATHADLLLTSASQRSPDSLKSSLKLLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPNVSTEEKSTQHDTPQLRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAKVDKLIERDSHNEEGAGGSSSKDGEADHTLEDSITSHPREDWYEQLHPLILTLKECMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLHDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLRKVAFKITEATSNDVLPVLTGRREHYVVEVKLPATVFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELVQEYYSIFMEKMPPDYISHFQEQTDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRRYAFNMLQLMAFPKCYRPPEGTYGKADT", "length": 927 }, "evidence": [ { "id": "F1MNJ3", "url": "https://omabrowser.org/oma/group/F1MNJ3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9QWG5-1", "protein_name": "Type II inositol 3,4-bisphosphate 4-phosphatase", "gene_name": "Inpp4b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEIKEEGTSEEGQHFLPAAQANDPEDIQFTSIQKSPNEPQLEFILACKDLVAPVSDRKLNTVVQVSVIHPVEQTLTRYSSTEIVEGTKDPLFLTGVTFPSDYPIYEETRIKLTVYDVKDKPHDTIRTSVLPEHKDPPPEVARSFLGCASFKVGELLKSKEQLLSLSLRTSDGGKVVGTIEVSLVKMGEIEDGDTDHITTDVQGQKCALVYDSTAPESLSGKENLPFMNAVLRNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQELKELGDLSPHWDNLRNNVLSHCDQMVTMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSSINQLQPLVATHADLLLTSASQHSPDSLRSSLKLLSEKTELFVHAFKDQLVRSALLALYTARPGGILRKPPSPKVSTEEKSSQHDSPQQLRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAKVDKLIERDSRNDKSTGGDSSKDGDADPNLEDSLTSHPREDWYEQLHPLILTLKECMAEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLHDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLRKVAFKITEATSNDVLPVLTGRREHYVVEVKLPATVFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELVQEYYSIFMEKMPPDYISHFQEQNDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRRYAFNMLQLMAFPKCYRPPEGTYGKADT", "length": 928 }, "evidence": [ { "id": "F1MNJ3", "url": "https://omabrowser.org/oma/group/F1MNJ3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MNJ3", "url": "https://www.uniprot.org/uniprotkb/F1MNJ3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity", "id": "GO:0016316", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016316", "evidence": [ { "database": "UniProtKB", "id": "F1MNJ3", "url": "https://www.uniprot.org/uniprotkb/F1MNJ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 196, "end_pos": 198, "annotation": "n_glycosylation_sequon" }, { "start_pos": 22, "end_pos": 24, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "43388", "name": "", "equation": "1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MNJ3-1", "A0A3Q1MZG3-1" ], "evidence": [ { "id": "43388", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43388" } ] }, { "id": "R-BTA-1676162", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, early endosome membrane", "input_participant_list": [ "R-ALL-1806238" ], "output_participant_list": [], "enzyme_list": [ "F1MNJ3-1", "A0A3Q1MZG3-1" ], "evidence": [ { "id": "R-BTA-1676162", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1676162" } ] }, { "id": "R-BTA-1676164", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MNJ3-1", "A0A3Q1MZG3-1" ], "evidence": [ { "id": "R-BTA-1676164", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1676164" } ] }, { "id": "R-BTA-1855180", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1629769" ], "enzyme_list": [ "F1MNJ3-1", "A0A3Q1MZG3-1" ], "evidence": [ { "id": "R-BTA-1855180", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855180" } ] }, { "id": "R-BTA-1855202", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1629731" ], "enzyme_list": [ "F1MNJ3-1", "A0A3Q1MZG3-1" ], "evidence": [ { "id": "R-BTA-1855202", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855202" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1629731", "participant_name": "I3P [cytosol]", "crossref": [ { "id": "ZINC000100028278", "database": "ZINC", "url": "" }, { "id": "C04006", "database": "COMPOUND", "url": "" }, { "id": "58401", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1629769", "participant_name": "I(1,3)P2 [cytosol]", "crossref": [ { "id": "ZINC000100016181", "database": "ZINC", "url": "" }, { "id": "83242", "database": "ChEBI", "url": "" }, { "id": "C04062", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-1806238", "participant_name": "PI(3,4)P2 [early endosome membrane]", "crossref": [ { "id": "16152", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MZG3", "gene_name": "INPP4A", "activity": [ { "ec_number": "3.1.3.66", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate.", "evidence": [ { "id": "A0A3Q1MZG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZG3" } ] }, { "ec_number": "3.1.3.66", "activity": "", "evidence": [ { "id": "A0A3Q1MZG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MZG3" } ] } ] }, { "uniprot_ac": "F1MNJ3", "gene_name": "INPP4B", "activity": [ { "ec_number": "3.1.3.66", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate.", "evidence": [ { "id": "F1MNJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNJ3" } ] }, { "ec_number": "3.1.3.66", "activity": "", "evidence": [ { "id": "F1MNJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNJ3" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MNJ3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 925, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MNJ3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MNJ3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MNJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNJ3" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 165, "start_aa": "Asp", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.66", "ec_name": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate.", "evidence": [ { "id": "3.1.3.66", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.66" }, { "id": "3.1.3.66", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.66" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 196, "end_pos": 198 }, { "start_pos": 22, "end_pos": 24 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 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"Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519770", "url": "https://www.ncbi.nlm.nih.gov/gene/519770", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005542", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005542", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050224", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050224", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:519770", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519770", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IYMGKTA", "url": "https://omabrowser.org/oma/group/IYMGKTA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LTL1", "url": "https://www.orthodb.org/?gene=A0A3Q1LTL1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LTN9", "url": "https://www.orthodb.org/?gene=A0A3Q1LTN9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MTS2", "url": "https://www.orthodb.org/?gene=F1MTS2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11850", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11850", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03792", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03792", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF05920", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05920", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179444", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTL1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTL1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTN9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LTN9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTS2-1", "url": "https://www.uniprot.org/uniprotkb/F1MTS2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDAPQRPPRPAPPPPAPRRSPPGPPPGSNTGDVLQQIMAITDQSLDEAQARKHALNCHRMKPALFSVLCEIKEKTVSSIHGIQEVGPPDAQLLRLDNMLLAEGVSRPEKQGRGASAAANAAMPGGRPNDSGLEHSDYRAKLSQIRQMYHSELEKYEQACREFTMHVTNLLQEQSRIRPVSPAEIEHMVGVIHGKFQSIQMQLKQSTCEAVMALRARFLDARRKRQNFSKQATEVLNEYFYSHLSNPYPSEEAKEELARRGGITVSQVSNWFGNKRIRYKKNMRKFQEEATIYTAKTAVDATEVRGSGRQASPPSMSHSSSSGPFPLTGPGDALIRLQTLACVQPSPRGGGLLAQARGGWQVKQMPTASPVGNPGSVTSDASN", "length": 382, "header": "tr|F1MTS2-1|F1MTS2_BOVIN Isoform 1 of PBX homeobox 4 OS=Bos taurus OX=9913 GN=PBX4 PE=3 SV=2 CANONICAL=F1MTS2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LTL1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTL1/entry", "sequence": { "sequence": "MAITDQSLDEAQARKHALNCHRMKPALFSVLCEIKEKTVSSIHGIQEVGPPDAQLLRLDNMLLAEGVSRPEKQGRGASAAANAAMPGGRPNDSGLEHSDYRAKLSQIRQMYHSELEKYEQACREFTMHVTNLLQEQSRIRPVSPAEIEHMVGVIHGKFQSIQMQLKQSTCEAVMALRARFLDARRKRQNFSKQATEVLNEYFYSHLSNPYPSEEAKEELARRGGITVSQVSNWFGNKRIRYKKNMRKFQEEATIYTAKTAVDATEVRGSGRQASPPSMSHSSSSGPFPLTGPGDALIRLQTLACVQPSPRGGGLLAQVSLWHNPKACGVPDPVTSRPGAPVVAGPRDRLPQPHRGLRKLS", "length": 360, "header": "tr|A0A3Q1LTL1-1|F1MTS2_BOVIN Computationally mapped isoform of PBX homeobox 4 OS=Bos taurus OX=9913 GN=PBX4 PE=3 SV=2 CANONICAL=F1MTS2-1" }, "locus": { "chromosome": "7", "start_pos": 3763483, "end_pos": 3711250, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068421.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068421.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060675.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060675.2" } ] } }, { "isoform_ac": "A0A3Q1LTN9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTN9/entry", "sequence": { "sequence": "MDAPQRPPRPAPPPPAPRRSPPGPPPGSNTGDVLQQIMAITDQSLDEAQARKHALNCHRMKPALFSVLCEIKEKTVSSIHGIQEVGPPDAQLLRLDNMLLAEGVSRPEKQGRGASAAANAAMPGGRPNDSGLEHSDYRAKLSQIRQMYHSELEKYEQACREFTMHVTNLLQEQSRIRPVSPAEIEHMVGVIHGKFQSIQMQLKQSTCEAVMALRARFLDARRKRQNFSKQATEVLNEYFYSHLSNPYPSEEAKEELARRGGITVSQVSNWFGNKRIRYKKNMRKFQEEATIYTAKTAVDATEVRGSGRQASPPSMSHSSSSGPFPLTGPGDALIRLQTLACVQPSPRGGGLLAQTFHTHRITQLEAFCVPLLPFGLFLGRPGHSEPQGN", "length": 389, "header": "tr|A0A3Q1LTN9-1|F1MTS2_BOVIN Computationally mapped isoform of PBX homeobox 4 OS=Bos taurus OX=9913 GN=PBX4 PE=3 SV=2 CANONICAL=F1MTS2-1" }, "locus": { "chromosome": "7", "start_pos": 3768420, "end_pos": 3711139, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075733.2", "url": "https://www.ensembl.org/id/ENSBTAT00000075733.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000060447.2", "url": "https://www.ensembl.org/id/ENSBTAP00000060447.2" } ] } }, { "isoform_ac": "F1MTS2-1", "url": "https://www.uniprot.org/uniprotkb/F1MTS2/entry", "sequence": { "sequence": "MDAPQRPPRPAPPPPAPRRSPPGPPPGSNTGDVLQQIMAITDQSLDEAQARKHALNCHRMKPALFSVLCEIKEKTVSSIHGIQEVGPPDAQLLRLDNMLLAEGVSRPEKQGRGASAAANAAMPGGRPNDSGLEHSDYRAKLSQIRQMYHSELEKYEQACREFTMHVTNLLQEQSRIRPVSPAEIEHMVGVIHGKFQSIQMQLKQSTCEAVMALRARFLDARRKRQNFSKQATEVLNEYFYSHLSNPYPSEEAKEELARRGGITVSQVSNWFGNKRIRYKKNMRKFQEEATIYTAKTAVDATEVRGSGRQASPPSMSHSSSSGPFPLTGPGDALIRLQTLACVQPSPRGGGLLAQARGGWQVKQMPTASPVGNPGSVTSDASN", "length": 382, "header": "tr|F1MTS2-1|F1MTS2_BOVIN Isoform 1 of PBX homeobox 4 OS=Bos taurus OX=9913 GN=PBX4 PE=3 SV=2 CANONICAL=F1MTS2-1" }, "locus": { "chromosome": "7", "start_pos": 3765478, "end_pos": 3711139, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013152.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013152.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013152.5", "url": "https://www.ensembl.org/id/ENSBTAP00000013152.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:519770", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:519770", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4AA41-1", "protein_name": "PBX homeobox 4", "gene_name": "Pbx4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAPLRPVPPQPAPRRSPPTAPLGHDTSDVLQQIMAITDQSLDEAQARKHALNCHRMKSALFSVLSEIKGKTAVSVQTQEEDPPDAQLLRLDNMLLAEGVSRPEKRGRGGAAAGSTATPGGCPNDNSIEHSDYRAKLSQIRQIYHSELEKYEQACREFTTHVTNLLREQSRVRPVSSGEIEHMVSTIHSKFSAIQRQLKQSTCEAVMTLRSRFLDARRKRRNFSKQATEVLNEYFYSHLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYKKNTGKFQEEATMYTGKTSTVTKTRVSGGQTSCQSTPSPDSCGPFPLTSGSDMVLTLRTLAFLQPPPGGVCLQPLAHGSWQRATTSQPSSSPAGDSGSFNSDASD", "length": 379 }, "evidence": [ { "id": "F1MTS2", "url": "https://omabrowser.org/oma/group/F1MTS2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99NE9-1", "protein_name": "Pre-B-cell leukemia transcription factor 4", "gene_name": "Pbx4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAPLRPVPPQPAPRRLPTTAPLGHDTSDVLQQIMAITDQSLDEAQARKHALNCHRMKSALFSVLCEIKGKTAVSIQFQEEDPPDAQLLRLDNMLLAEGVSRPEKRGRGAAAGSTATPGGCPNDNSIEHSDYRAKLSQIRQIYHSELEKYEQACREFTTHVTNLLREQSRVRPVSCREMEHMVNTIQSKFSAIQRQLKQSTCEAVMTLRSRFLDARRKRRNFSKQATDVLNEYFYSHLSNPYPSEETKEELARKGGITVSQVSNWFGNKRIRYKKNTGKFQEEATMYTGKASTVTKARRPRGQSSCQSTPSPGPCGPLPLTNGSDVVLTLRTLAFLQPPTGGVCLQPLVHSNWQRAAPQPASSPAGESGSFNWDAASN", "length": 378 }, "evidence": [ { "id": "F1MTS2", "url": "https://omabrowser.org/oma/group/F1MTS2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BYU1-1", "protein_name": "Pre-B-cell leukemia transcription factor 4", "gene_name": "PBX4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAPPRPAPSPPAPRRLDTSDVLQQIMAITDQSLDEAQARKHALNCHRMKPALFSVLCEIKEKTVVSIRGIQDEDPPDAQLLRLDNMLLAEGVCRPEKRGRGGAVARAGTATPGGCPNDNSIEHSDYRAKLSQIRQIYHSELEKYEQACREFTTHVTNLLQEQSRMRPVSPKEIERMVGAIHGKFSAIQMQLKQSTCEAVMTLRSRLLDARRKRRNFSKQATEVLNEYFYSHLNNPYPSEEAKEELARKGGLTISQVSNWFGNKRIRYKKNMGKFQEEATIYTGKTAVDTTEVGVPGNHASCLSTPSSGSSGPFPLPSAGDAFLTLRTLASLQPPPGGGCLQSQAQGSWQGATPQPATASPAGDPGSINSSTSN", "length": 374 }, "evidence": [ { "id": "F1MTS2", "url": "https://omabrowser.org/oma/group/F1MTS2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" } ], "pmid": "" }, { "name": "XY body", "id": "GO:0001741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001741", "evidence": [ { "database": "UniProtKB", "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" } ], "pmid": "" }, { "name": "animal organ morphogenesis", "id": "GO:0009887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009887", "evidence": [ { "database": "UniProtKB", "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" } ], "pmid": "" }, { "name": "embryonic organ development", "id": "GO:0048568", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048568", "evidence": [ { "database": "UniProtKB", "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" } ], "pmid": "" }, { "name": "eye development", "id": "GO:0001654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001654", "evidence": [ { "database": "UniProtKB", "id": "F1MTS2", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 226, "end_pos": 228, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MTS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 218, "end_pos": 281, "start_aa": "Leu", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MTS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTS2" }, { "id": "PS51978", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51978" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PBC", "eco_id": "ECO_0000259", "start_pos": 25, "end_pos": 219, "start_aa": "Pro", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 }, { "start_pos": 226, "end_pos": 228 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", 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"table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MQ09-1", "uniprot_ac": "F1MQ09", "uniprot_id": "F1MQ09_BOVIN", "mass": { "chemical_mass": 89234.0, "monoisotopic_mass": 89234.0 }, "refseq": {}, "gene_names": [ { "name": "VEZT", "type": "recommended", "evidence": [ { "id": "F1MQ09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ09" } ] } ], "protein_names": [ { "name": "Vezatin", "type": "recommended", "evidence": [ { "id": "F1MQ09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ09/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MQ09", "url": "https://www.uniprot.org/uniprotkb/F1MQ09" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "VEZT", "url": "https://www.uniprot.org/uniprotkb/F1MQ09", "locus": { "chromosome": "5", "start_pos": 24940076, "end_pos": 24868874, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014044", "url": "https://www.ensembl.org/id/ENSBTAG00000014044" } ] } } ], "crossref": [ { "id": "F1MQ09", "url": "https://alphafold.ebi.ac.uk/entry/F1MQ09", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014044", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014044", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR026858", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026858", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR15989", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15989", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15989:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15989:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF12632", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12632", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LUX7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LUX7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQ09", "url": "https://www.uniprot.org/uniprotkb/F1MQ09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQ09-1", "url": "https://www.uniprot.org/uniprotkb/F1MQ09-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTPDFDEEVVFENSPLYQYLQDLGHTDFEVCSSLSPKAEKSAVTEGQQKPPARALPKQGILLKVAETIKSWILAQSNKNDDLLHKLDIGFRLDSLHTILQQEVLLQEDVELIELLDASILSAGQPQQQENGHLPTLCSLATPNIWDVSVVFAFISLLVMLPTWWILSSWLVWGVIVFVYLIIRALRLWRTAKLQVTLKKYSVYLEDIATDSRGFTNLVRKALRLIQETEVISRGFTLLLDRVSAACLFNKAGQHPSQHLIGLRKAVYRTVRANFQAARLATLYMLKKTYPLNSESDNVTNYICVVPFKELGLGLSEEQISEEEAHNLTDGFSLPALKVLFQLWVAQSSEFFRRLALLLSTTNSPPGPLLTPALLPHRILSDVTQGLPHVHSACLEELKRSYEFYRYFETQHQSVPQRFSRTQQKSRELSNVHTAVRSLQLHLKALLNEVIILEDELEKLVCIKETQELVSEAYQILEQKLKLIQPHVQASNNCWEEAISQVDKLLRRNTDKKGHPEMACESPRCTVAPVLQPPLHIADKDPIPEEQELEAYVDDVDMDTDFRKDDFYYLSQEDRERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAVLKSLSPVDPVEPISNSEPSVDSDMGKVGKNDTEEENNKTSTADNEISSRTEYLCEYPVDGKSKDNSANEVFFQGAEERAHYQCESEDESPQADVDGLAPAHPTPRVSSQPSIKQRLAQLQLSPGFTFTAGLAAEVAARSLSFTTMQEQTFGDEEEEHIIQENENEVEEK", "length": 786, "header": "tr|F1MQ09-1|F1MQ09_BOVIN Isoform 1 of Vezatin OS=Bos taurus OX=9913 GN=VEZT PE=3 SV=4 CANONICAL=F1MQ09-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LUX7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LUX7/entry", "sequence": { "sequence": "MLSNSPLYQYLQDLGHTDFEVCSSLSPKAEKSAVTEGQQKPPARALPKQGILLKVAETIKSWILAQSNKNDDLLHKLDIGFRLDSLHTILQQEVLLQEDVELIELLDASILSAGQPQQQENGHLPTLCSLATPNIWDVSVVFAFISLLVMLPTWWILSSWLVWGVIVFVYLIIRALRLWRTAKLQVTLKKYSVYLEDIATDSRGFTNLVRKALRLIQETEVISRGFTLVSAACLFNKAGQHPSQHLIGLRKAVYRTVRANFQAARLATLYMLKNYPLNSESDNVTNYICVVPFKELGLGLSEEQISEEEAHNLTDGFSLPALKVLFQLWVAQSSEFFRRLALLLSTTNSPPGPLLTPALLPHRILSDVTQGLPHVHSACLEELKRSYEFYRYFETQHQSVPQRFSRTQQKSRELSNVHTAVRSLQLHLKALLNEVIILEDELEKLVCIKETQELVSEAYQILEQKLKLIQPHVQASNNCWEEAISQVDKLLRRNTDKKGHPEMACESPRCTVAPVLQPPLHIADKDPIPEEQELEAYVDDVDMDTDFRKDDFYYLSQEDRERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAVLKSLSPVDPVEPISNSEPSVDSDMGKVGKNDTEEENNKTSTADNEISSRTEYLCEYPVDGKSKDNSANEVFFQGAEERAHYQCESEDESPQADVDGLAPAHPTPRVSSQPSIKQRLAQLQLSPGFTFTAGLAAEVAARSLSFTTMQEQTFGDEEEEHIIQENENEVEEK", "length": 772, "header": "tr|A0A3Q1LUX7-1|F1MQ09_BOVIN Computationally mapped isoform of Vezatin OS=Bos taurus OX=9913 GN=VEZT PE=3 SV=1 CANONICAL=F1MQ09-1" }, "locus": { "chromosome": "5", "start_pos": 24939565, "end_pos": 24885244, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000085733.3", "url": "https://www.ensembl.org/id/ENSBTAT00000085733.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061167.1", "url": "https://www.ensembl.org/id/ENSBTAP00000061167.1" } ] } }, { "isoform_ac": "F1MQ09-1", "url": "https://www.uniprot.org/uniprotkb/F1MQ09/entry", "sequence": { "sequence": "MTPDFDEEVVFENSPLYQYLQDLGHTDFEVCSSLSPKAEKSAVTEGQQKPPARALPKQGILLKVAETIKSWILAQSNKNDDLLHKLDIGFRLDSLHTILQQEVLLQEDVELIELLDASILSAGQPQQQENGHLPTLCSLATPNIWDVSVVFAFISLLVMLPTWWILSSWLVWGVIVFVYLIIRALRLWRTAKLQVTLKKYSVYLEDIATDSRGFTNLVRKALRLIQETEVISRGFTLLLDRVSAACLFNKAGQHPSQHLIGLRKAVYRTVRANFQAARLATLYMLKKTYPLNSESDNVTNYICVVPFKELGLGLSEEQISEEEAHNLTDGFSLPALKVLFQLWVAQSSEFFRRLALLLSTTNSPPGPLLTPALLPHRILSDVTQGLPHVHSACLEELKRSYEFYRYFETQHQSVPQRFSRTQQKSRELSNVHTAVRSLQLHLKALLNEVIILEDELEKLVCIKETQELVSEAYQILEQKLKLIQPHVQASNNCWEEAISQVDKLLRRNTDKKGHPEMACESPRCTVAPVLQPPLHIADKDPIPEEQELEAYVDDVDMDTDFRKDDFYYLSQEDRERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAVLKSLSPVDPVEPISNSEPSVDSDMGKVGKNDTEEENNKTSTADNEISSRTEYLCEYPVDGKSKDNSANEVFFQGAEERAHYQCESEDESPQADVDGLAPAHPTPRVSSQPSIKQRLAQLQLSPGFTFTAGLAAEVAARSLSFTTMQEQTFGDEEEEHIIQENENEVEEK", "length": 786, "header": "tr|F1MQ09-1|F1MQ09_BOVIN Isoform 1 of Vezatin OS=Bos taurus OX=9913 GN=VEZT PE=3 SV=4 CANONICAL=F1MQ09-1" }, "locus": { "chromosome": "5", "start_pos": 24939565, "end_pos": 24869088, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018670.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018670.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018670.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018670.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MQ09", "url": "https://www.uniprot.org/uniprotkb/F1MQ09" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MQ09", "url": "https://www.uniprot.org/uniprotkb/F1MQ09" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "F1MQ09", "url": "https://www.uniprot.org/uniprotkb/F1MQ09" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MQ09", "url": "https://www.uniprot.org/uniprotkb/F1MQ09" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell-cell adhesion", "id": "GO:0098609", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098609", "evidence": [ { "database": "UniProtKB", "id": "F1MQ09", "url": "https://www.uniprot.org/uniprotkb/F1MQ09" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "myosin binding", "id": "GO:0017022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017022", "evidence": [ { "database": "UniProtKB", "id": "F1MQ09", "url": "https://www.uniprot.org/uniprotkb/F1MQ09" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 297, "end_pos": 299, "annotation": "n_glycosylation_sequon" }, { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" }, { "start_pos": 647, "end_pos": 649, "annotation": "n_glycosylation_sequon" }, { "start_pos": 654, "end_pos": 656, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MQ09-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 786, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MQ09-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MQ09" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MQ09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ09" }, { "id": "PF12632", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12632" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Myosin-binding", "eco_id": "ECO_0000259", "start_pos": 150, "end_pos": 443, "start_aa": "Val", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 297, "end_pos": 299 }, { "start_pos": 326, "end_pos": 328 }, { "start_pos": 647, "end_pos": 649 }, { "start_pos": 654, "end_pos": 656 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MKX1-1", "uniprot_ac": "F1MKX1", "uniprot_id": "F1MKX1_BOVIN", "mass": { "chemical_mass": 42109.0, "monoisotopic_mass": 42109.0 }, "refseq": {}, "gene_names": [ { "name": "WNT9A", "type": "recommended", "evidence": [ { "id": "F1MKX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKX1" } ] } ], "protein_names": [ { "name": "Protein Wnt", "type": "recommended", "evidence": [ { "id": "F1MKX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKX1/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Ligand for members of the frizzled family of seven transmembrane receptors.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LWY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWY7#function" }, { "database": "UniProtKB", "id": "RU003500", "url": "https://www.uniprot.org/uniprotkb/RU003500#function" }, { "database": "UniProtKB", "id": "F1MKX1", "url": "https://www.uniprot.org/uniprotkb/F1MKX1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MKX1", "url": "https://www.uniprot.org/uniprotkb/F1MKX1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WNT9A", "url": "https://www.uniprot.org/uniprotkb/F1MKX1", "locus": { "chromosome": "7", "start_pos": 3164593, "end_pos": 3134768, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020267", "url": "https://www.ensembl.org/id/ENSBTAG00000020267" } ] } } ], "crossref": [ { "id": "F1MKX1", "url": "https://alphafold.ebi.ac.uk/entry/F1MKX1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020267", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020267", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511308", "url": "https://www.ncbi.nlm.nih.gov/gene/511308", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005817", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005817", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013303", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013303", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043158", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043158", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511308", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511308", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PTHR12027", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12027", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12027:SF75", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12027:SF75", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00110", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00110", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LWY7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWY7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWY7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWY7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKX1", "url": "https://www.uniprot.org/uniprotkb/F1MKX1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKX1-1", "url": "https://www.uniprot.org/uniprotkb/F1MKX1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLDGPLLARWLAAAFALTLLLAALRPSAAYFGLTGSEPLTILPLTLEPEAVAQAHYKACDRLKLERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFLGRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKRLKHKYETALKVGSTTNEATGEAGAISPPRGRAAGAGGGDPLPRTPELVHLDDSPSFCVAGRFSPGTAGRRCHREKNCESICCGRGHNTQSRVVTRPCQCQQRISQRKYVCGGVQTPQPRDRGGRAMLRGQAGPGHLLSAQRA", "length": 384, "header": "tr|F1MKX1-1|F1MKX1_BOVIN Isoform 1 of Protein Wnt OS=Bos taurus OX=9913 GN=WNT9A PE=3 SV=3 CANONICAL=F1MKX1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LWY7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWY7/entry", "sequence": { "sequence": "MLDGPLLARWLAAAFALTLLLAALRPSAAYFGLTGSEPLTILPLTLEPEAVAQAHYKACDRLKLERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFLGRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKRLKHKYETALKVGSTTNEATGEAGAISPPRGRAAGAGGGDPLPRTPELVHLDDSPSFCVAGRFSPGTAGRRCHREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCKG", "length": 365, "header": "tr|A0A3Q1LWY7-1|F1MKX1_BOVIN Computationally mapped isoform of Protein Wnt OS=Bos taurus OX=9913 GN=WNT9A PE=3 SV=2 CANONICAL=F1MKX1-1" }, "locus": { "chromosome": "7", "start_pos": 3162236, "end_pos": 3135053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076702.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076702.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065242.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065242.2" } ] } }, { "isoform_ac": "F1MKX1-1", "url": "https://www.uniprot.org/uniprotkb/F1MKX1/entry", "sequence": { "sequence": "MLDGPLLARWLAAAFALTLLLAALRPSAAYFGLTGSEPLTILPLTLEPEAVAQAHYKACDRLKLERKQRRMCRRDPGVAETLVEAVSMSALECQYQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFLGRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKRLKHKYETALKVGSTTNEATGEAGAISPPRGRAAGAGGGDPLPRTPELVHLDDSPSFCVAGRFSPGTAGRRCHREKNCESICCGRGHNTQSRVVTRPCQCQQRISQRKYVCGGVQTPQPRDRGGRAMLRGQAGPGHLLSAQRA", "length": 384, "header": "tr|F1MKX1-1|F1MKX1_BOVIN Isoform 1 of Protein Wnt OS=Bos taurus OX=9913 GN=WNT9A PE=3 SV=3 CANONICAL=F1MKX1-1" }, "locus": { "chromosome": "7", "start_pos": 3164592, "end_pos": 3135053, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027007.6", "url": "https://www.ensembl.org/id/ENSBTAT00000027007.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027007.6", "url": "https://www.ensembl.org/id/ENSBTAP00000027007.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511308", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511308", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "F1MKX1", "url": "https://www.uniprot.org/uniprotkb/F1MKX1" } ], "pmid": "" }, { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "F1MKX1", "url": "https://www.uniprot.org/uniprotkb/F1MKX1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MKX1", "url": "https://www.uniprot.org/uniprotkb/F1MKX1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "F1MKX1", "url": "https://www.uniprot.org/uniprotkb/F1MKX1" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "F1MKX1", "url": "https://www.uniprot.org/uniprotkb/F1MKX1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 103, "end_pos": 105, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MKX1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 384, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MKX1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MKX1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 103, "end_pos": 105 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MRA8-1", "uniprot_ac": "F1MRA8", "uniprot_id": "F1MRA8_BOVIN", "mass": { "chemical_mass": 85911.0, "monoisotopic_mass": 85911.0 }, "refseq": {}, "gene_names": [ { "name": "ADAM7", "type": "recommended", "evidence": [ { "id": "F1MRA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" } ] } ], "protein_names": [ { "name": "ADAM metallopeptidase domain 7", "type": "synonym", "evidence": [ { "id": "F1MRA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRA8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MRA8", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ADAM7", "url": "https://www.uniprot.org/uniprotkb/F1MRA8", "locus": { "chromosome": "8", "start_pos": 71704975, "end_pos": 71653618, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000039171", "url": "https://www.ensembl.org/id/ENSBTAG00000039171" } ] } } ], "crossref": [ { "id": "F1MRA8", "url": "https://alphafold.ebi.ac.uk/entry/F1MRA8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000039171", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000039171", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04269", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04269", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001762", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006586", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006586", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018358", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018358", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034027", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034027", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LXC1", "url": "https://www.orthodb.org/?gene=A0A3Q1LXC1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MRA8", "url": "https://www.orthodb.org/?gene=F1MRA8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11905", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11905", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11905:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11905:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00200", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00200", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01421", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01421", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01562", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01562", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LXC1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXC1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKT0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKT0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRA8", "url": "https://www.uniprot.org/uniprotkb/F1MRA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRA8-1", "url": "https://www.uniprot.org/uniprotkb/F1MRA8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFPGSLCFMILLIFQIKEKVILGVEGQELVHPKRLPLIQKRDVWHIHEDDIQEAYEEELLYQLNLNRKILIIHLLKSRELLALNYSETYYSTKGEEITKHPQITDHCFYQGSILHEFDSAVSISTCHGLRGFFRVRDQRYLIEPVKYSDEGEHLVFKYDPLMQQPANYSCTELNFTRTTIPKGNTKSLEDSKMESKEKEKHIELFIVADDNMYRRNSQPHSRLRNRVWGMVNFVNMIYKTLNIHVTLVGLEIWTNGDKIEVDSNIETTLLRFSAWQEIILKKRKNFDHSMLLSGKWLYTQAHGTSYPGGMCLPYYSSSVVKDLLPDLNAIASRMAHQLGHNLGMSHDDYLCTCDLEKCVMNSGGSIPALKFSKCSKTQYQQFLKDYSLTCMFNVPFSDNFSDYPYCGNNRLDDGEECDCGLLQDCTNPCCDAHKCMLKPGFTCAEGECCESCQMKKAGSICRPARTECDFPERCTGHSSGCPKDQFQVNGFPCKNAKGYCFMGNCPTRDDQCSELFDHEAKASSDICYKMNTIGNKFGYCKNKGRILIPCEEKDIKCGKIFCTGGHHSSVLGEEKIYHLKKHLKQNTSECKTFYLYHDSKDFGLVAPGTKCGDGMVCSNGECVTIEKAYNSTDCSAQCNENSVDDGELECQCEGIQASTEWEETLNVTNLCILVVVLFLVIFGVVVVILLIRYKKCIRLKQVQSPPRETLGVENKAYFGDEQQTRNEPILPDIHPLHKSANKEHRGMADPNSSAK", "length": 755, "header": "tr|F1MRA8-1|F1MRA8_BOVIN Isoform 1 of ADAM metallopeptidase domain 7 OS=Bos taurus OX=9913 GN=ADAM7 PE=4 SV=3 CANONICAL=F1MRA8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXC1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXC1/entry", "sequence": { "sequence": "MFPGSLCFMILLIFQIKEKVILGVEGQELVHPKRLPLIQKRDVWHIHEDDIQEAYEEELLYQLNLNRKILIIHLLKSRELLALNYSETYYSTKGEEITKHPQITDHCFYQGSILHEFDSAVSISTCHGLRGFFRVRDQRYLIEPVKYSDEGEHLVFKYDPLMQQPANYSCTELNFTRTTIPKGNTKSLEDSKMESKEKEKHIELFIVADDNMYRRNSQPHSRLRNRVWGMVNFVNMIYKTLNIHVTLVGLEIWTNGDKIEVDSNIETTLLRFSAWQEIILKKRKNFDHSMLLSGKWLYTQAHGTSYPGGMCLPYYSSSVVKDLLPDLNAIASRMAHQLGHNLGMSHDDYLCTCDLEKCVMNSGGSIPALKFSKCSKTQYQQFLKDYSLTCMFNVPFSDNFSDYPYCGNNRLDDGEECDCGLLQDCTNPCCDAHKCMLKPGFTCAEGECCESCQMKKAGSICRPARTECDFPERCTGHSSGCPKDQFQVNGFPCKNAKGYCFMGNCPTRDDQCSELFDHEAKASSDICYKMNTIGNKFGYCKNKGRILIPCEEKDIKCGKIFCTGGHHSSVLGEEKIYHLKKHLKQNTSECKTFYLYHDSKDFGLVAPGTKCGDGMVCSNGECVTIEKAYNSTDCSAQCNENSVDDGELECQCEGIQASTEWEETLNVTNLCILVVVLFLVIFGVVVVILLIRYKKCIRLKQVQSPPRETLGVENKAYFGDEQQTRNEPILPDIHPLHRRNTESLERLPTSFSSPHYITLKSANKEHRGMADPNSSAK", "length": 777, "header": "tr|A0A3Q1LXC1-1|F1MRA8_BOVIN Computationally mapped isoform of ADAM metallopeptidase domain 7 OS=Bos taurus OX=9913 GN=ADAM7 PE=4 SV=2 CANONICAL=F1MRA8-1" }, "locus": { "chromosome": "8", "start_pos": 71703526, "end_pos": 71653618, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000083953.2", "url": "https://www.ensembl.org/id/ENSBTAT00000083953.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062141.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062141.2" } ] } }, { "isoform_ac": "A0AAA9TKT0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKT0/entry", "sequence": { "sequence": "MFPGSLCFMILLIFQIKEKVILGVEGQELVHPKRLPLIQKRDVWHIHEDDIQEAYEEELLYQLNLNRKILIIHLLKSRELLALNYSETYYSTKGEEITKHPQITDHCFYQGSILHEFDSAVSISTCHGLRGFFRVRDQRYLIEPVKYSDEGEHLVFKYDPLMQQPANYSCTELNFTRTTIPKGNTKSLEDSKMEVSALLSFLSHVKCLLFFF", "length": 212, "header": "tr|A0AAA9TKT0-1|F1MRA8_BOVIN Computationally mapped isoform of ADAM metallopeptidase domain 7 OS=Bos taurus OX=9913 GN=ADAM7 PE=4 SV=1 CANONICAL=F1MRA8-1" }, "locus": { "chromosome": "8", "start_pos": 71667594, "end_pos": 71653618, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126512.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126512.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097793.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097793.1" } ] } }, { "isoform_ac": "F1MRA8-1", "url": "https://www.uniprot.org/uniprotkb/F1MRA8/entry", "sequence": { "sequence": "MFPGSLCFMILLIFQIKEKVILGVEGQELVHPKRLPLIQKRDVWHIHEDDIQEAYEEELLYQLNLNRKILIIHLLKSRELLALNYSETYYSTKGEEITKHPQITDHCFYQGSILHEFDSAVSISTCHGLRGFFRVRDQRYLIEPVKYSDEGEHLVFKYDPLMQQPANYSCTELNFTRTTIPKGNTKSLEDSKMESKEKEKHIELFIVADDNMYRRNSQPHSRLRNRVWGMVNFVNMIYKTLNIHVTLVGLEIWTNGDKIEVDSNIETTLLRFSAWQEIILKKRKNFDHSMLLSGKWLYTQAHGTSYPGGMCLPYYSSSVVKDLLPDLNAIASRMAHQLGHNLGMSHDDYLCTCDLEKCVMNSGGSIPALKFSKCSKTQYQQFLKDYSLTCMFNVPFSDNFSDYPYCGNNRLDDGEECDCGLLQDCTNPCCDAHKCMLKPGFTCAEGECCESCQMKKAGSICRPARTECDFPERCTGHSSGCPKDQFQVNGFPCKNAKGYCFMGNCPTRDDQCSELFDHEAKASSDICYKMNTIGNKFGYCKNKGRILIPCEEKDIKCGKIFCTGGHHSSVLGEEKIYHLKKHLKQNTSECKTFYLYHDSKDFGLVAPGTKCGDGMVCSNGECVTIEKAYNSTDCSAQCNENSVDDGELECQCEGIQASTEWEETLNVTNLCILVVVLFLVIFGVVVVILLIRYKKCIRLKQVQSPPRETLGVENKAYFGDEQQTRNEPILPDIHPLHKSANKEHRGMADPNSSAK", "length": 755, "header": "tr|F1MRA8-1|F1MRA8_BOVIN Isoform 1 of ADAM metallopeptidase domain 7 OS=Bos taurus OX=9913 GN=ADAM7 PE=4 SV=3 CANONICAL=F1MRA8-1" }, "locus": { "chromosome": "8", "start_pos": 71703526, "end_pos": 71653618, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056180.3", "url": "https://www.ensembl.org/id/ENSBTAT00000056180.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048800.3", "url": "https://www.ensembl.org/id/ENSBTAP00000048800.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "F1MRA8", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MRA8", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MRA8", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "F1MRA8", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1MRA8", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" } ], "pmid": "" }, { "name": "epithelial cell morphogenesis", "id": "GO:0003382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003382", "evidence": [ { "database": "UniProtKB", "id": "F1MRA8", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" } ], "pmid": "" }, { "name": "positive regulation of flagellated sperm motility", "id": "GO:1902093", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902093", "evidence": [ { "database": "UniProtKB", "id": "F1MRA8", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" } ], "pmid": "" }, { "name": "epididymis development", "id": "GO:1905867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905867", "evidence": [ { "database": "UniProtKB", "id": "F1MRA8", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" } ], "pmid": "" }, { "name": "positive regulation of sperm capacitation", "id": "GO:1902492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902492", "evidence": [ { "database": "UniProtKB", "id": "F1MRA8", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 174, "end_pos": 176, "annotation": "n_glycosylation_sequon" }, { "start_pos": 399, "end_pos": 401, "annotation": "n_glycosylation_sequon" }, { "start_pos": 586, "end_pos": 588, "annotation": "n_glycosylation_sequon" }, { "start_pos": 630, "end_pos": 632, "annotation": "n_glycosylation_sequon" }, { "start_pos": 666, "end_pos": 668, "annotation": "n_glycosylation_sequon" }, { "start_pos": 751, "end_pos": 753, "annotation": "n_glycosylation_sequon" }, { "start_pos": 84, "end_pos": 86, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MRA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" }, { "id": "PS50214", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50214" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Disintegrin", "eco_id": "ECO_0000259", "start_pos": 403, "end_pos": 489, "start_aa": "Tyr", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MRA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" }, { "id": "PS50215", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50215" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Peptidase M12B", "eco_id": "ECO_0000259", "start_pos": 200, "end_pos": 395, "start_aa": "Lys", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [ { "evidence": [ { "id": "PRU00276", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00276" }, { "id": "F1MRA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" } ], "binding_site_uniprot": 336, "amino_acid": "His", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 336, "end_pos": 336, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "PRU00276", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00276" }, { "id": "F1MRA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" } ], "binding_site_uniprot": 340, "amino_acid": "His", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 340, "end_pos": 340, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] }, { "evidence": [ { "id": "PRU00276", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00276" }, { "id": "F1MRA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRA8" } ], "binding_site_uniprot": 346, "amino_acid": "His", "chebi_lig_id": "CHEBI:29105", "ligand": "Zn(2+)", "ligand_label": "", "uniprotkb_ligand_comment": "catalytic", "eco_id": "ECO_0000256", "start_pos": 346, "end_pos": 346, "start_aa": "His", "end_aa": "His", "glycosite_overlap": [] } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 167, "end_pos": 169 }, { "start_pos": 174, "end_pos": 176 }, { "start_pos": 399, "end_pos": 401 }, { "start_pos": 586, "end_pos": 588 }, { "start_pos": 630, "end_pos": 632 }, { "start_pos": 666, "end_pos": 668 }, { "start_pos": 751, "end_pos": 753 }, { "start_pos": 84, "end_pos": 86 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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"table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MM05-1", "uniprot_ac": "F1MM05", "uniprot_id": "F1MM05_BOVIN", "mass": { "chemical_mass": 75680.0, "monoisotopic_mass": 75680.0 }, "refseq": {}, "gene_names": [ { "name": "MAU2", "type": "recommended", "evidence": [ { "id": "F1MM05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM05" } ] } ], "protein_names": [ { "name": "MAU2 chromatid cohesion factor homolog", "type": "recommended", "evidence": [ { "id": "F1MM05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM05/entry#names_and_taxonomy" } ] }, { "name": "Cohesin loading complex subunit SCC4 homolog", "type": "synonym", "evidence": [ { "id": "F1MM05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM05/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MM05", "url": "https://www.uniprot.org/uniprotkb/F1MM05" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MAU2", "url": "https://www.uniprot.org/uniprotkb/F1MM05", "locus": { "chromosome": "7", "start_pos": 3929007, "end_pos": 3966094, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006124", "url": "https://www.ensembl.org/id/ENSBTAG00000006124" } ] } } ], "crossref": [ { "id": "F1MM05", "url": "https://alphafold.ebi.ac.uk/entry/F1MM05", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006124", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006124", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019440", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019440", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QDAWYLS", "url": "https://omabrowser.org/oma/group/QDAWYLS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M2H9", "url": "https://www.orthodb.org/?gene=A0A3Q1M2H9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MM05", "url": "https://www.orthodb.org/?gene=F1MM05", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10345", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10345", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2470946", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2470946", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M2H9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M2H9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8U5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S8U5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFM1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SFM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM05", "url": "https://www.uniprot.org/uniprotkb/F1MM05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM05-1", "url": "https://www.uniprot.org/uniprotkb/F1MM05-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPFLRPSWSRRHFKHKLHTPGCFVQQLSRERRGAPAPPHAPVSASLWRRLVVVEAKMAAQAAAAAQAAAAQAAQAEAAESWYLALLGFAEHFRTSSPPKIRLCVHCLQAVFPFKPPQRIEARTHLQLGSVLYHHTKNSEQARSHLEKAWLISQQITQFEDVKFEAASLLSELYCQENSVDAAKPLLRKAIQISQQTPYWHCRLLFQLAQLHTLEKDLVSACDLLGVGAEYARVVGSEYTRALFLLSKGMLLLMERKLQEVHPLLTLCGQIVENWQGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSSFQVILLEHIIMCRLVTGHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCVSVNCMDNAEAQFTTALRLTNHQELWAFIVTNLASVYIREGNRHQEVLYSLLERINPDHSFPVSSHCLRAAAFYVRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHEAAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPNTSLASLL", "length": 670, "header": "tr|F1MM05-1|F1MM05_BOVIN Isoform 1 of MAU2 chromatid cohesion factor homolog OS=Bos taurus OX=9913 GN=MAU2 PE=3 SV=3 CANONICAL=F1MM05-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M2H9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M2H9/entry", "sequence": { "sequence": "MSPFLRPSWSRRHFKHKLHTPGCFVQQLSRERRGAPAPPHAPVSASLWRRLVVVEAKMAAQAAAAAQAAAAQAAQAEAAESWYLALLGFAEHFRTSSPPKIRLCVHCLQAVFPFKPPQRIEARTHLQLGSVLYHHTKNSEQARSHLEKANSVDAAKPLLRKAIQISQQTPYWHCRLLFQLAQLHTLEKDLVSACDLLGVGAEYARVVGSEYTRALFLLSKGMLLLMERKLQEVHPLLTLCGQIVENWQGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSSFQVILLEHIIMCRLVTGHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCVSVNCMDNAEAQFTTALRLTNHQELWAFIVTNLASVYIREGNRHQEVLYSLLERINPDHSFPVSSHCLRAAAFYVRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHEAAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPNTSLASLL", "length": 642, "header": "tr|A0A3Q1M2H9-1|F1MM05_BOVIN Computationally mapped isoform of MAU2 chromatid cohesion factor homolog OS=Bos taurus OX=9913 GN=MAU2 PE=3 SV=2 CANONICAL=F1MM05-1" }, "locus": { "chromosome": "7", "start_pos": 3965897, "end_pos": 3930011, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067376.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067376.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063996.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063996.2" } ] } }, { "isoform_ac": "A0AAA9S8U5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S8U5/entry", "sequence": { "sequence": "MSPFLRPSWSRRHFKHKLHTPGCFVQQLSRERRGAPAPPHAPVSASLWRRLVVVEAKMAAQAAAAAQAAAAQAAQAEAAESWYLALLGFAEHFRTSSPPKIRLCVHCLQAVFPFKPPQRIEARTHLQLGSVLYHHTKNSEQARSHLEKAWLISQQITQFEDVKFEAASLLSELYCQENSVDAAKPLLRKAIQISQQTPYWHCRLLFQLAQLHTLEKDLVSACDLLGVGAEYARVVGSEYTRALFLLSKGMVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSSFQVILLEHIIMCRLVTGHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCVSVNCMDNAEAQFTTALRLTNHQELWAFIVTNLASVYIREGNRHQEVLYSLLERINPDHSFPVSSHCLRAAAFYVRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHEAAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPNTSLASLL", "length": 618, "header": "tr|A0AAA9S8U5-1|F1MM05_BOVIN Computationally mapped isoform of MAU2 chromatid cohesion factor homolog OS=Bos taurus OX=9913 GN=MAU2 PE=3 SV=1 CANONICAL=F1MM05-1" }, "locus": { "chromosome": "7", "start_pos": 3965897, "end_pos": 3930011, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119460.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119460.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081703.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081703.1" } ] } }, { "isoform_ac": "A0AAA9SFM1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SFM1/entry", "sequence": { "sequence": "MGDVVRLGKPTPTIAWTSGVFPPGTQTSANRQSLVSVTRTRECRLFSDLPGAAATSNTNYILQDALCSSSREKGEELRPRPTRLFPPPCGGGLLLWRLKWRLRLRRRLRLRRPKQRRPRRLSRGTWRSWALPSTSALPARPRSACACTACRPCSPSSRLSALRPEHICSSARCSTTTPRTASRRAATWRRRIPWMQQSRCCGKPSRSPSRPRTGTAACSSSSLALFLLSKGMLLLMERKLQEVHPLLTLCGQIVENWQGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSSFQVILLEHIIMCRLVTGHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCVSVNCMDNAEAQFTTALRLTNHQELWAFIVTNLASVYIREGNRHQEVLYSLLERINPDHSFPVSSHCLRAAAFYVRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHEAAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPNTSLASLL", "length": 652, "header": "tr|A0AAA9SFM1-1|F1MM05_BOVIN Computationally mapped isoform of MAU2 chromatid cohesion factor homolog OS=Bos taurus OX=9913 GN=MAU2 PE=3 SV=1 CANONICAL=F1MM05-1" }, "locus": { "chromosome": "7", "start_pos": 3966022, "end_pos": 3930011, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117003.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117003.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081257.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081257.1" } ] } }, { "isoform_ac": "F1MM05-1", "url": "https://www.uniprot.org/uniprotkb/F1MM05/entry", "sequence": { "sequence": "MSPFLRPSWSRRHFKHKLHTPGCFVQQLSRERRGAPAPPHAPVSASLWRRLVVVEAKMAAQAAAAAQAAAAQAAQAEAAESWYLALLGFAEHFRTSSPPKIRLCVHCLQAVFPFKPPQRIEARTHLQLGSVLYHHTKNSEQARSHLEKAWLISQQITQFEDVKFEAASLLSELYCQENSVDAAKPLLRKAIQISQQTPYWHCRLLFQLAQLHTLEKDLVSACDLLGVGAEYARVVGSEYTRALFLLSKGMLLLMERKLQEVHPLLTLCGQIVENWQGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSSFQVILLEHIIMCRLVTGHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCVSVNCMDNAEAQFTTALRLTNHQELWAFIVTNLASVYIREGNRHQEVLYSLLERINPDHSFPVSSHCLRAAAFYVRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHEAAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPNTSLASLL", "length": 670, "header": "tr|F1MM05-1|F1MM05_BOVIN Isoform 1 of MAU2 chromatid cohesion factor homolog OS=Bos taurus OX=9913 GN=MAU2 PE=3 SV=3 CANONICAL=F1MM05-1" }, "locus": { "chromosome": "7", "start_pos": 3965897, "end_pos": 3930011, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000008054.7", "url": "https://www.ensembl.org/id/ENSBTAT00000008054.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000008054.6", "url": "https://www.ensembl.org/id/ENSBTAP00000008054.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-2470946", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2470946", "resource": "Reactome", "description": "Cohesin Loading onto Chromatin" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AEC9-1", "protein_name": "MAU2 chromatid cohesion factor homolog", "gene_name": "MAU2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAVAAGAAGGAAPQQQPPPQQQPQPAAGGAAGSGEAGGGGGGAGGGGGGGAGGAGPGPGSGSGGGAAGGGGESWYLALLGLAEHFRTSSPPKVRLCVHCLQAVLPRKPPARMEARTHLQLGSVLYHHTRNGEQARGHLEKAWLISQQIPQFEDVKFEAASLLSELYCQENSVDTAKPLLRKAIQISQQTPYWHCRLLFQLAQLHTLEKDLVSACDLLGVGAEYARVVGSEYTRALFLLSKGMLLLMERKLQEVHPLLTLCGQIVENWQGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSSFQVILLEHIIMCRLVTGHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCISVNCMDNAEAQFTTALRLTTHQELWAFIVTNLASVYIREGNRHQELYSLLERINPDHNFPVSSHCLRAAAFYIRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHEAAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPTTSLASLL", "length": 662 }, "evidence": [ { "id": "F1MM05", "url": "https://omabrowser.org/oma/group/F1MM05/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3Z8G8-1", "protein_name": "MAU2 chromatid cohesion factor homolog", "gene_name": "Mau2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAQAAAAAQAAAAAQAAAAQAAQAEAAESWYLALLGFAEHFRTSSPPKIRLCVHCLQAVFPFKPPQRIEARTHLQLGSVLYHHTKNSEQARSHLEKAWLISQQIPQFEDVKFEAASLLSELYCQENSVDAAKPLLRKAIQISQQTPYWHCRLLFQLAQLHTLEKDLVSACDLLGVGAEYARVVGSEYTRALFLLSKGMLLLMERKLQEVHPLLTLCGQIVENWQGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSSFQVILLEHIIMCRLVTGHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCVSVNCMDNAEAQFTTALRLTNHQELWAFIVTNLASVYIREGNRHQEVLYSLLERINPDHSFPVSSHCLRAAAFYVRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHEAAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPNTSLASLL", "length": 619 }, "evidence": [ { "id": "F1MM05", "url": "https://omabrowser.org/oma/group/F1MM05/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D2X5-1", "protein_name": "MAU2 chromatid cohesion factor homolog", "gene_name": "Mau2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAQAAAAAQAAAAAQAAAAQAAQAEAAESWYLALLGFAEHFRTSSPPKIRLCVHCLQAVFPFKPPQRIEARTHLQLGSVLYHHTKNSEQARSHLEKAWLISQQIPQFEDVKFEAASLLSELYCQENSVDAAKPLLRKAIQISQQTPYWHCRLLFQLAQLHTLEKDLVSACDLLGVGAEYARVVGSEYTRALFLLSKGMLLLMERKLQEVHPLLTLCGQIVENWQGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSSFQVILLEHIIMCRLVTGHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCVSVNCMDNAEAQFTTALRLTNHQELWAFIVTNLASVYIREGNRHQEVLYSLLERINPDHSFPVSSHCLRAAAFYVRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHEAAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPNTSLASLL", "length": 619 }, "evidence": [ { "id": "F1MM05", "url": "https://omabrowser.org/oma/group/F1MM05/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9FGN7-1", "protein_name": "Sister chromatid cohesion protein SCC4", "gene_name": "SCC4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEGAAVAEGLWGLADHHQKLGEIGKTIKCLEAICQSQISFLPLVEVKSRLRLAALLLRYSHNVNHAKSHLERSLLLLKSIPSSYDLKFQNYSLLSHCYHLLASFPPQRNLLVKALELASSVPQDISAYLWSCNFNSQLANTFIIQADFPSSLSALESGFLSASHICFPELQMFFTASMLHVHIMQWTDDYSVEKAVQRCDEIWQTISSDKTDRCPGLFFYNEMLHVFYRLRLCDYKNAQHHVDRLDQAMNAHSHKMQEIQQLLDELSSLNLSLSRYDLPSRERSALSARQSQLQDRVNALSPSSSTVNSLEPAYFGNIDRGWTEKLLLSPSPIDGEWLPKSAIDALVHLMVVISGRPKGLFKECSKRIESGLQIIQDELIKLGITDEVREADLRHTAIWMSRVFLMLQMQFLENRVALELTRSDYVEAEEALVDMKNWFTRFPTILQASECMIEMLRGQYSHSVGCYSEAAFHCIEATKLTESISMQASCQAFAAVSYLTIGDAESSSKALDLIGPLNGMTNSLSGVREEASILFAYGLLLMKQRDLQEARNRLAKGLQIAHNHMGNLQLVAQYLTLLGNLALSLHDTVQAREILRSSLTLAKKLYDIPTQLWVLSIFTALYQQLGEKGNEMENEEFRKKKWDELQSRLAEARGSIHHIELVAKARIELYQIDNNPQEQSLVASAQSMQGNLDIPESVGIEGPSPAPSSSRLVGLDTGKRWGKRRM", "length": 726 }, "evidence": [ { "id": "F1MM05", "url": "https://omabrowser.org/oma/group/F1MM05/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9VFC0-1", "protein_name": "MAU2 chromatid cohesion factor homolog", "gene_name": "Mau2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSASTSTSTAASQDACYISLLGLAEYFRTSQPPNIKKCIQCLQALFTFMPPSKVEARTHLQMGQILMAYTKNIDLARQHLEKAWSISEPLPNFDVKFDTASLLAQLHLQTDRNSHQAKAMLRRAVELSQNNVYWHCKLLLQLAQIHASDREYSLASELLAVGAESADEASATYLKVLFLLSRAMILMIERKTNDVLALLNSAGQIIDNNIPNPHQKEYLKVFFLVLQVCYYLALGQVKTVKPSLKQLQMSIQTIMAPNWPSDEAIFGANQLEMFVWLPKEQLYVLVYLVTVSHSMMAGYMDKAQKYTEKALTQIEKLKQQEDKPILSVFKVILLEHIVMCRMVMGNRELAIREIAAARDVCMAAPQRSLLRRHSAQLHCLIGLYSMSTNLFEHAERQFVVCVSETSERDLKLFANLNLAIIYLRTKRDTDLKQILDAVSTENTHTYSSQALMGGFYYVQGLHAFHKNSFHEAKRFLRETLKMANAEDLNRLTSCSLVLLSHVFLSIGNSKESMNMVTPAMQLASKIPDIHVQLWGSAILKDLHRMSKDVQHEKDAYANHVKYSENLIADQRKCVQSAHHELVNWFQGDPPVTSGPPAAPVLLMPESSVTASVPVIASTSTAMQPAGQYGQFY", "length": 632 }, "evidence": [ { "id": "F1MM05", "url": "https://omabrowser.org/oma/group/F1MM05/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y6X3-1", "protein_name": "MAU2 chromatid cohesion factor homolog", "gene_name": "MAU2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAQAAAAAQAAAAQAAQAEAADSWYLALLGFAEHFRTSSPPKIRLCVHCLQAVFPFKPPQRIEARTHLQLGSVLYHHTKNSEQARSHLEKAWLISQQIPQFEDVKFEAASLLSELYCQENSVDAAKPLLRKAIQISQQTPYWHCRLLFQLAQLHTLEKDLVSACDLLGVGAEYARVVGSEYTRALFLLSKGMLLLMERKLQEVHPLLTLCGQIVENWQGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNPADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSSFQVILLEHIIMCRLVTGHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCVSVNCMDNAEAQFTTALRLTNHQELWAFIVTNLASVYIREGNRHQEVLYSLLERINPDHSFPVSSHCLRAAAFYVRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHIFYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHEAAQMHQNFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPNTSLASLL", "length": 613 }, "evidence": [ { "id": "F1MM05", "url": "https://omabrowser.org/oma/group/F1MM05/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MM05", "url": "https://www.uniprot.org/uniprotkb/F1MM05" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1MM05", "url": "https://www.uniprot.org/uniprotkb/F1MM05" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "F1MM05", "url": "https://www.uniprot.org/uniprotkb/F1MM05" } ], "pmid": "" }, { "name": "SMC loading complex", "id": "GO:0032116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032116", "evidence": [ { "database": "UniProtKB", "id": "F1MM05", "url": "https://www.uniprot.org/uniprotkb/F1MM05" } ], "pmid": "" }, { "name": "Scc2-Scc4 cohesin loading complex", "id": "GO:0090694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090694", "evidence": [ { "database": "UniProtKB", "id": "F1MM05", "url": "https://www.uniprot.org/uniprotkb/F1MM05" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "F1MM05", "url": "https://www.uniprot.org/uniprotkb/F1MM05" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "F1MM05", "url": "https://www.uniprot.org/uniprotkb/F1MM05" } ], "pmid": "" }, { "name": "mitotic sister chromatid cohesion", "id": "GO:0007064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007064", "evidence": [ { "database": "UniProtKB", "id": "F1MM05", "url": "https://www.uniprot.org/uniprotkb/F1MM05" } ], "pmid": "" }, { "name": "maintenance of mitotic sister chromatid cohesion", "id": "GO:0034088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034088", "evidence": [ { "database": "UniProtKB", "id": "F1MM05", "url": "https://www.uniprot.org/uniprotkb/F1MM05" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cohesin loader activity", "id": "GO:0061775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061775", "evidence": [ { "database": "UniProtKB", "id": "F1MM05", "url": "https://www.uniprot.org/uniprotkb/F1MM05" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 624, "end_pos": 626, "annotation": "n_glycosylation_sequon" }, { "start_pos": 663, "end_pos": 665, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MM05-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 670, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MM05-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MM05" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 624, "end_pos": 626 }, { "start_pos": 663, "end_pos": 665 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MS93-1", "uniprot_ac": "F1MS93", "uniprot_id": "F1MS93_BOVIN", "mass": { "chemical_mass": 84834.0, "monoisotopic_mass": 84834.0 }, "refseq": {}, "gene_names": [ { "name": "THOC5", "type": "recommended", "evidence": [ { "id": "F1MS93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS93" } ] } ], "protein_names": [ { "name": "THO complex subunit 5", "type": "synonym", "evidence": [ { "id": "F1MS93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS93/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MS93", "url": "https://www.uniprot.org/uniprotkb/F1MS93" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "THOC5", "url": "https://www.uniprot.org/uniprotkb/F1MS93", "locus": { "chromosome": "17", "start_pos": 68701005, "end_pos": 68731933, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013150", "url": "https://www.ensembl.org/id/ENSBTAG00000013150" } ] } } ], "crossref": [ { "id": "F1MS93", "url": "https://alphafold.ebi.ac.uk/entry/F1MS93", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013150", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013150", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "533001", "url": "https://www.ncbi.nlm.nih.gov/gene/533001", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YEVMHLK", "url": "https://omabrowser.org/oma/group/YEVMHLK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A140T8B2", "url": "https://www.orthodb.org/?gene=A0A140T8B2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MS93", "url": "https://www.orthodb.org/?gene=F1MS93", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13375", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13375", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13375:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13375:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09766", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09766", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-159236", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159236", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A140T8B2", "url": "https://www.uniprot.org/uniprotkb/A0A140T8B2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A140T8B2-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T8B2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBX0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBX0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TBX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBX0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS93", "url": "https://www.uniprot.org/uniprotkb/F1MS93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS93-1", "url": "https://www.uniprot.org/uniprotkb/F1MS93-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLKPQSPDAGSRTLSGTRPGAVWYSTLLTTRVPSEAQLPDHLHSLPQCNASCFNVHYHPGESSKKRKPKVIRSDGAPAEGKRTRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSRGGKDAAVEIEDRRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTMGDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKMLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVLLDLKCKDDSVLHLTFYYLMNLNIMTVKARVTTATELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLRDYVLDLGHPYLWVQKLGGLHFPKEQPQHTVITDHSLSASHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCHYLFPAKVVSRLVKWVTIAHEDYTELHFTKDIVEAGLAGDTNLYYMALVERGTAKLQAAVVLNPGYSSIPPIFQLCLNWKGEKTNNNDDNIRAMESEVNVCYKELCGPRPGHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRIKPFKYNHPQGFFSHR", "length": 741, "header": "tr|F1MS93-1|F1MS93_BOVIN Isoform 1 of THO complex subunit 5 OS=Bos taurus OX=9913 GN=THOC5 PE=3 SV=2 CANONICAL=F1MS93-1" }, "isoforms": [ { "isoform_ac": "A0A140T8B2-1", "url": "https://www.uniprot.org/uniprotkb/A0A140T8B2/entry", "sequence": { "sequence": "MSSESSKKRKPKVIRSDGAPAEGKRTRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSRGGKDAAVEIEDRRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTMGDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACAHRKSSQPPRQDKMLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVLLDLKCKDDSVLHLTFYYLMNLNIMTVKARVTTATELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLRDYVLDLGHPYLWVQKLGGLHFPKEQPQHTVITDHSLSASHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCHYLFPAKVVSRLVKWVTIAHEDYTELHFTKDIVEAGLAGDTNLYYMALVERGTAKLQAAVVLNPGYSSIPPIFQLCLNWKGEKTNNNDDNIRAMESEVNVCYKELCGPRPGHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRIKPFKYNHPQGFFSHR", "length": 694, "header": "tr|A0A140T8B2-1|F1MS93_BOVIN Computationally mapped isoform of THO complex subunit 5 OS=Bos taurus OX=9913 GN=THOC5 PE=3 SV=1 CANONICAL=F1MS93-1" }, "locus": { "chromosome": "17", "start_pos": 68730094, "end_pos": 68701140, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000029505.5", "url": "https://www.ensembl.org/id/ENSBTAT00000029505.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000029505.3", "url": "https://www.ensembl.org/id/ENSBTAP00000029505.3" } ] } }, { "isoform_ac": "A0AAA9TBX0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TBX0/entry", "sequence": { "sequence": "MSSESSKKRKPKVIRSDGAPAEGKRTRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSRGGKDAAVEIEDRRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTMGDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVLLDLKCKDDSVLHLTFYYLMNLNIMTVKARVTTATELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLRDYVLDLGHPYLWVQKLGGLHFPKEQPQHTVITDHSLSASHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCHYLFPAKVVSRLVKWVTIAHEDYTELHFTKDIVEAGLAGDTNLYYMALVERGTAKLQAAVVLNPGYSSIPPIFQLCLNWKGEKTNNNDDNIRAMESEVNVCYKELCGPRPGHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRIKPFKYNHPQGFFSHR", "length": 657, "header": "tr|A0AAA9TBX0-1|F1MS93_BOVIN Computationally mapped isoform of THO complex subunit 5 OS=Bos taurus OX=9913 GN=THOC5 PE=3 SV=1 CANONICAL=F1MS93-1" }, "locus": { "chromosome": "17", "start_pos": 68730094, "end_pos": 68701140, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106367.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106367.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095530.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095530.1" } ] } }, { "isoform_ac": "F1MS93-1", "url": "https://www.uniprot.org/uniprotkb/F1MS93/entry", "sequence": { "sequence": "MVLKPQSPDAGSRTLSGTRPGAVWYSTLLTTRVPSEAQLPDHLHSLPQCNASCFNVHYHPGESSKKRKPKVIRSDGAPAEGKRTRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSRGGKDAAVEIEDRRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTMGDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKMLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVLLDLKCKDDSVLHLTFYYLMNLNIMTVKARVTTATELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLRDYVLDLGHPYLWVQKLGGLHFPKEQPQHTVITDHSLSASHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCHYLFPAKVVSRLVKWVTIAHEDYTELHFTKDIVEAGLAGDTNLYYMALVERGTAKLQAAVVLNPGYSSIPPIFQLCLNWKGEKTNNNDDNIRAMESEVNVCYKELCGPRPGHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRIKPFKYNHPQGFFSHR", "length": 741, "header": "tr|F1MS93-1|F1MS93_BOVIN Isoform 1 of THO complex subunit 5 OS=Bos taurus OX=9913 GN=THOC5 PE=3 SV=2 CANONICAL=F1MS93-1" }, "locus": { "chromosome": "17", "start_pos": 68731826, "end_pos": 68701140, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017479.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017479.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017479.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017479.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-159236", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-159236", "resource": "Reactome", "description": "Transport of Mature mRNA derived from an Intron-Containing Transcript" } ], "orthologs": [ { "uniprot_canonical_ac": "Q13769-1", "protein_name": "THO complex subunit 5", "gene_name": "THOC5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSRGGKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYKEAPPDISKAEVTMGDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVTTAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSASHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIVDAGLAGDTNLYYMALIERGTAKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPKEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR", "length": 683 }, "evidence": [ { "id": "F1MS93", "url": "https://omabrowser.org/oma/group/F1MS93/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BKT7-1", "protein_name": "THO complex subunit 5 homolog", "gene_name": "Thoc5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSESSKKRKPKVIRSDGTPTEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSKGSKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYSEAPPSISKAEITMGDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKRDYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVLLDLKCKDNSVLHLTFYYLMNLNIMTVKAKVTTAVELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLRDYVLELGHPYLWVQKLGGLHFPKEQPQQTVMPDHSQSASHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQDLFPAKVVSRLVKWVIITHEDYMELHFTKDIVEAGLAGDTNLYYLALIERGTAKLQAAVVLNPGYSSIPPVFRLCLNWKGEKTNSNDDNIRAMESEVNVCYKELCGPRPSHQLLTNQLQRLCVLLDVYLETESHDDSFEGPKEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR", "length": 683 }, "evidence": [ { "id": "F1MS93", "url": "https://omabrowser.org/oma/group/F1MS93/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "mRNA binding", "id": "GO:0003729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003729", "evidence": [ { "database": "UniProtKB", "id": "F1MS93", "url": "https://www.uniprot.org/uniprotkb/F1MS93" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mRNA export from nucleus", "id": "GO:0006406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006406", "evidence": [ { "database": "UniProtKB", "id": "F1MS93", "url": "https://www.uniprot.org/uniprotkb/F1MS93" } ], "pmid": "" }, { "name": "monocyte differentiation", "id": "GO:0030224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030224", "evidence": [ { "database": "UniProtKB", "id": "F1MS93", "url": "https://www.uniprot.org/uniprotkb/F1MS93" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "THO complex part of transcription export complex", "id": "GO:0000445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000445", "evidence": [ { "database": "UniProtKB", "id": "F1MS93", "url": "https://www.uniprot.org/uniprotkb/F1MS93" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MS93", "url": "https://www.uniprot.org/uniprotkb/F1MS93" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MS93", "url": "https://www.uniprot.org/uniprotkb/F1MS93" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "F1MS93", "url": "https://www.uniprot.org/uniprotkb/F1MS93" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MS93-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 741, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MS93-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MS93" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 50, "end_pos": 52 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MRN5-1", "uniprot_ac": "F1MRN5", "uniprot_id": "F1MRN5_BOVIN", "mass": { "chemical_mass": 387895.0, "monoisotopic_mass": 387895.0 }, "refseq": { "ac": "XP_024842094", "name": "CUB and sushi domain-containing protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842094" }, "gene_names": [ { "name": "CSMD1", "type": "recommended", "evidence": [ { "id": "F1MRN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRN5" } ] }, { "name": "CSMD1", "type": "synonym", "evidence": [ { "id": "XP_024842094", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842094" } ] } ], "protein_names": [ { "name": "CUB and Sushi multiple domains 1", "type": "synonym", "evidence": [ { "id": "F1MRN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRN5/entry#names_and_taxonomy" } ] }, { "name": "CUB and sushi domain-containing protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024842094", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842094" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MRN5", "url": "https://www.uniprot.org/uniprotkb/F1MRN5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CSMD1", "url": "https://www.uniprot.org/uniprotkb/F1MRN5", "locus": { "chromosome": "27", "start_pos": 2152105, "end_pos": 4213247, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009739", "url": "https://www.ensembl.org/id/ENSBTAG00000009739" } ] } } ], "crossref": [ { "id": "ENSBTAG00000009739", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009739", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00033", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00033", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00041", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00041", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "526825", "url": "https://www.ncbi.nlm.nih.gov/gene/526825", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051277", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051277", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:526825", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526825", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LF38", "url": "https://www.orthodb.org/?gene=A0A3Q1LF38", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LJJ8", "url": "https://www.orthodb.org/?gene=A0A3Q1LJJ8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MRN5", "url": "https://www.orthodb.org/?gene=F1MRN5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45656", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45656", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45656:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45656:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00084", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00084", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00431", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00431", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024842094", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024842094", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LF38", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LF38-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJJ8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJJ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LJJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJJ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRN5", "url": "https://www.uniprot.org/uniprotkb/F1MRN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRN5-1", "url": "https://www.uniprot.org/uniprotkb/F1MRN5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTAWGKFESLLLALLALCAGLLTAAQGQNCGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEEDFDILSVYDGQLQQGNLKVRLSGFQLPSSIVSSGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGNPGEILKGVLHGTRFNIGDKIRYSCLSGYVLEGHAILTCIVSPGNGASWDFPAPFCRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELKSRGVKVMPSKDSSHKNSVLTQGGVALVSDMCPDPGIPENGRRVGSDFRVGANVQFSCEDNYVLQGSKSITCQRVTDTLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRTVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIASPGFKAIYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECQAAFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLNCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFSTDNSRSSVGFLIRYESVTLESDSCLDPGIPVNGHRHGSHFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCGGYIHGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLEPCDDPGVPAFSRRIGFHFGVGDALTFSCFPGYRLEGATKLTCLGGGRRVWSAPLPRCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRARSFQLFEGDILKVYDGKDSSSRPLGAFTRNELVGLILNSTSNHLWLEFNSNGSDTDQGFQLTYTSFDLVKCEDPGTPNYGYRIRDEGHFTDTVILYSCNPGYAMHGGGTLTCLSGDRRVWDRPLPSCVAECGGRIHAATSGRILSPGYPAPYDNNLHCTWVVEADPGKTISLHFIVFDTELAHDILRVWDGPADSAILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSVQFSTSIASTCNDPGMPQNGTRYGDSREPGDTITFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVRVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNSPLIGSFQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREACFDPGNIMNGTRIGTDFKLGSTVTYQCDSGYKIADPSSITCVIGGDGKPAWNRVLPSCNAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGTHPQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGAPARGFHFVYQAVPRTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFECSPGYLLQGSTAIRCQSVPNALAQWNDTIPSCVVPCSGNFTQRRGTILSPGFPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIYDGGDASAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQEPALPSNGIKTGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIATCGGTLNSMGGVVLSPGFPGTYPNNLDCTWKISLPIGYGAHIQFLNFSTEANHDYLEIQNGPYHTSPMIGQFSGPDLPSALLSTTHETLIHFYSDHSQNRPGFKLTYQAYELQNCPDPPPFQNGYMVNSDYSVGQSISFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLISVPPGHGVYINFTLLQTEAVNDYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFVLNFHAFQLKKCQPPPAVPQAEMLTEDEDFEIGDFVKYQCHPGYTLSGMDTLTCKLSSQLQFEGSLPTCEAQCPANEVRTESSGVILSPGYPGNYFNSQTCSWSIRVEPNYNITIFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSKSNQLYLRWSTDHATSKKGFKIRYSAPYCSLTHTVKNGGVLNRTAGEVGSKVQYFCKPGYRMIGHSNATCRRNPVGMYQWDSLAPLCQAVSCGIPESPGNGSFTGNEFTLDSKVTYDCNEGFKLDASQQATAVCQEDGFWSNRGKPPTCKPVTCPGIEAQLSEHVTWRLVSGSLNEYGAQVVLSCSPGYYLEGQRLLQCHANGTWSAGEERPRCRVISCGSLSFPPNGNKIGTLTVYGATAIFTCNSGYTLVGSHVRECLANGLWSGPETRCLAGHCGSPDPIVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGHTPVCVPITCGHPGNPAHGLTNGSEFNLNDMVNFTCNPGYLLQGASRAQCRSNGQWSSPLPTCRVVNCSDPGLVENAVRHEHQNLPEGFEYGVTVVYQCKRGFYLLGSSALTCMANGLWDRSLPKCLVISCGHPGVPANAILTGDLFTYGAVVHYSCRGSRSLVGDSSRACQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGEEFKAKSLLRFSCEMGYQLRGSAERTCLLNGSWSGLQPVCEAVSCGNPGTPTHGKIVSSDGVLFSSSVVYACWDGYRTSGLTTRHCTANGTWTGTAPDCTLISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYTMEPATSPTIRCTKDSTWNHSKPTCKAVMCGQPPPVQDGKVEGTDFRWGASISYSCAHGFQLSQPAILSCEGRGVWKGEVPQCLPVFCGDPGTPAEGRLSGKIFTYRSEVFFQCKSPFLLVGSSRRVCQADGTWSGVQPTCIDPAHNTCPDPGTPQFGIQNSSRGYEVGSMVFFRCRKGYHVQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKSKGVREVNETVTKTPVPSDVFFIHSVWKGYYEYLGKRQPATLTVDWFNATSSKVNATFTDSQGELKLTGVYKKEEAHLLLKAFQIKGPVDIFVSNFENDNWGLDGYVSSGLERGGFTFQGDIHGKDFGKFKLERQDPVSSDQDSSSHYQGTSSGSVAAAILVPFFALILSGFAFYLYKHRTRPKVQYNGYAGHENSNGQASFENPMYDTNLKPTEAKAVRFDTTLNTVCTVV", "length": 3561, "header": "tr|F1MRN5-1|F1MRN5_BOVIN Isoform 1 of CUB and Sushi multiple domains 1 OS=Bos taurus OX=9913 GN=CSMD1 PE=3 SV=4 CANONICAL=F1MRN5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LF38-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LF38/entry", "sequence": { "sequence": "MTAWGKFESLLLALLALCAGLLTAAQGQNCGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEEDFDILSVYDGQLQQGNLKVRLSGFQLPSSIVSSGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGNPGEILKGVLHGTRFNIGDKIRYSCLSGYVLEGHAILTCIVSPGNGASWDFPAPFCRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELKSRGVKVMPSKDSSHKNSVLTQGGVALVSDMCPDPGIPENGRRVGSDFRVGANVQFSCEDNYVLQGSKSITCQRVTDTLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRTVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIASPGFKAIYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECQAAFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLNCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFSTDNSRSSVGFLIRYESVTLESDSCLDPGIPVNGHRHGSHFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCGGYIHGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLEPCDDPGVPAFSRRIGFHFGVGDALTFSCFPGYRLEGATKLTCLGGGRRVWSAPLPRCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRARSFQLFEGDILKVYDGKDSSSRPLGAFTRNELVGLILNSTSNHLWLEFNSNGSDTDQGFQLTYTSFDLVKCEDPGTPNYGYRIRDEGHFTDTVILYSCNPGYAMHGGGTLTCLSGDRRVWDRPLPSCVAECGGRIHAATSGRILSPGYPAPYDNNLHCTWVVEADPGKTISLHFIVFDTELAHDILRVWDGPADSAILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSVQFSTSIASTCNDPGMPQNGTRYGDSREPGDTITFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVRVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNSPLIGSFQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREACFDPGNIMNGTRIGTDFKLGSTVTYQCDSGYKIADPSSITCVIGGDGKPAWNRVLPSCNAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGTHPQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGAPARGFHFVYQAVPRTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFECSPGYLLQGSTAIRCQSVPNALAQWNDTIPSCVVPCSGNFTQRRGTILSPGFPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIYDGGDASAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQEPALPSNGIKTGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIATCGGTLNSMGGVVLSPGFPGTYPNNLDCTWKISLPIGYGAHIQFLNFSTEANHDYLEIQNGPYHTSPMIGQFSGPDLPSALLSTTHETLIHFYSDHSQNRPGFKLTYQAYELQNCPDPPPFQNGYMVNSDYSVGQSISFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLISVPPGHGVYINFTLLQTEAVNDYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFVLNFHAFQLKKCQPPPAVPQAEMLTEDEDFEIGDFVKYQCHPGYTLSGMDTLTCKLSSQLQFEGSLPTCEAQCPANEVRTESSGVILSPGYPGNYFNSQTCSWSIRVEPNYNITIFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSKSNQLYLRWSTDHATSKKGFKIRYSAPYCSLTHTVKNGGVLNRTAGEVGSKVQYFCKPGYRMIGHSNATCRRNPVGMYQWDSLAPLCQAVSCGIPESPGNGSFTGNEFTLDSKVTYDCNEGFKLDASQQATAVCQEDGFWSNRGKPPTCKPVTCPGIEAQLSEHVTWRLVSGSLNEYGAQVVLSCSPGYYLEGQRLLQCHANGTWSAGEERPRCRAGHCGSPDPIVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGHTPVCVPITCGHPGNPAHGLTNGSEFNLNDMVNFTCNPGYLLQGASRAQCRSNGQWSSPLPTCRVVNCSDPGLVENAVRHEHQNLPEGFEYGVTVVYQCKRGFYLLGSSALTCMANGLWDRSLPKCLVISCGHPGVPANAILTGDLFTYGAVVHYSCRGSRSLVGDSSRACQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGEEFKAKSLLRFSCEMGYQLRGSAERTCLLNGSWSGLQPVCEAVMCGQPPPVQDGKVEGTDFRWGASISYSCAHGFQLSQPAILSCEGRGVWKGEVPQCLPVFCGDPGTPAEGRLSGKIFTYRSEVFFQCKSPFLLVGSSRRVCQADGTWSGVQPTCIDPAHNTCPDPGTPQFGIQNSSRGYEVGSMVFFRCRKGYHVQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKSKGVREVNETVTKTPVPSDVFFIHSVWKGYYEYLGKRQPATLTVDWFNATSSKVNATFTDSQGELKLTGVYKKEEAHLLLKAFQIKGPVDIFVSNFENDNWGLDGYVSSGLERGGFTFQGDIHGKDFGKFKLERQDPVSSDQDSSSHYQGTSSGSVAAAILVPFFALILSGFAFYLYKHRTRPKVQYNGYAGHENSNGQASFENPMYDTNLKPTEAKAVRFDTTLNTVCTVV", "length": 3384, "header": "tr|A0A3Q1LF38-1|F1MRN5_BOVIN Computationally mapped isoform of CUB and Sushi multiple domains 1 OS=Bos taurus OX=9913 GN=CSMD1 PE=3 SV=2 CANONICAL=F1MRN5-1" }, "locus": { "chromosome": "27", "start_pos": 4213044, "end_pos": 2152164, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086592.2", "url": "https://www.ensembl.org/id/ENSBTAT00000086592.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000056675.2", "url": "https://www.ensembl.org/id/ENSBTAP00000056675.2" } ] } }, { "isoform_ac": "A0A3Q1LJJ8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJJ8/entry", "sequence": { "sequence": "MTAWGKFESLLLALLALCAGLLTAAQGQNCGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEEDFDILSVYDGQLQQGNLKVRLSGFQLPSSIVSSGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGNPGEILKGVLHGTRFNIGDKIRYSCLSGYVLEGHAILTCIVSPGNGASWDFPAPFCRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELKSRGVKVMPSKDSSHKNSVLTQGGVALVSDMCPDPGIPENGRRVGSDFRVGANVQFSCEDNYVLQGSKSITCQRVTDTLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRTVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIASPGFKAIYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECQAAFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLNCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFSTDNSRSSVGFLIRYESVTLESDSCLDPGIPVNGHRHGSHFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCGGYIHGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLEPCDDPGVPAFSRRIGFHFGVGDALTFSCFPGYRLEGATKLTCLGGGRRVWSAPLPRCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRARSFQLFEGDILKVYDGKDSSSRPLGAFTRNELVGLILNSTSNHLWLEFNSNGSDTDQGFQLTYTSFDLVKCEDPGTPNYGYRIRDEGHFTDTVILYSCNPGYAMHGGGTLTCLSGDRRVWDRPLPSCVAECGGRIHAATSGRILSPGYPAPYDNNLHCTWVVEADPGKTISLHFIVFDTELAHDILRVWDGPADSAILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSVQFSTSIASTCNDPGMPQNGTRYGDSREPGDTITFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVRVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNSPLIGSFQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREACFDPGNIMNGTRIGTDFKLGSTVTYQCDSGYKIADPSSITCVIGGDGKPAWNRVLPSCNAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGTHPQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGAPARGFHFVYQAVPRTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFECSPGYLLQGSTAIRCQSVPNALAQWNDTIPSCVVPCSGNFTQRRGTILSPGFPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIYDGGDASAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQEPALPSNGIKTGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIATCGGTLNSMGGVVLSPGFPGTYPNNLDCTWKISLPIGYGAHIQFLNFSTEANHDYLEIQNGPYHTSPMIGQFSGPDLPSALLSTTHETLIHFYSDHSQNRPGFKLTYQAYELQNCPDPPPFQNGYMVNSDYSVGQSISFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLISVPPGHGVYINFTLLQTEAVNDYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFVLNFHAFQLKKCQPPPAVPQAEMLTEDEDFEIGDFVKYQCHPGYTLSGMDTLTCKLSSQLQFEGSLPTCEAQCPANEVRTESSGVILSPGYPGNYFNSQTCSWSIRVEPNYNITIFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSKSNQLYLRWSTDHATSKKGFKIRYSAPYCSLTHTVKNGGVLNRTAGEVGSKVQYFCKPGYRMIGHSNATCRRNPVGMYQWDSLAPLCQAVSCGIPESPGNGSFTGNEFTLDSKVTYDCNEGFKLDASQQATAVCQEDGFWSNRGKPPTCKPVTCPGIEAQLSEHVTWRLVSGSLNEYGAQVVLSCSPGYYLEGQRLLQCHANGTWSAGEERPRCRVISCGSLSFPPNGNKIGTLTVYGATAIFTCNSGYTLVGSHVRECLANGLWSGPETRCLAGHCGSPDPIVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGHTPVCVPITCGHPGNPAHGLTNGSEFNLNDMVNFTCNPGYLLQGASRAQCRSNGQWSSPLPTCRVVNCSDPGLVENAVRHEHQNLPEGFEYGVTVVYQCKRGFYLLGSSALTCMANGLWDRSLPKCLVISCGHPGVPANAILTGDLFTYGAVVHYSCRGSRSLVGDSSRACQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGEEFKAKSLLRFSCEMGYQLRGSAERTCLLNGSWSGLQPVCEAVSCGNPGTPTHGKIVSSDGVLFSSSVVYACWDGYRTSGLTTRHCTANGTWTGTAPDCTLISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYTMEPATSPTIRCTKDSTWNHSKPTCKAVMCGQPPPVQDGKVEGTDFRWGASISYSCAHGFQLSQPAILSCEGRGVWKGEVPQCLPVFCGDPGTPAEGRLSGKIFTYRSEVFFQCKSPFLLVGSSRRVCQADGTWSGVQPTCIDPAHNTCPDPGTPQFGIQNSSRGYEVGSMVFFRCRKGYHVQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKIPSDVFFIHSVWKGYYEYLGKRQPATLTVDWFNATSSKVNATFTDSQGELKLTGVYKKEEAHLLLKAFQIKGPVDIFVSNFENDNWGLDGYVSSGLERGGFTFQGDIHGKDFGKFKLERQDPVSSDQDSSSHYQGTSSGSVAAAILVPFFALILSGFAFYLYKHRTRPKVQYNGYAGHENSNGQASFENPMYDTNLKPTEAKAVRFDTTLNTVCTVV", "length": 3546, "header": "tr|A0A3Q1LJJ8-1|F1MRN5_BOVIN Computationally mapped isoform of CUB and Sushi multiple domains 1 OS=Bos taurus OX=9913 GN=CSMD1 PE=3 SV=2 CANONICAL=F1MRN5-1" }, "locus": { "chromosome": "27", "start_pos": 4213044, "end_pos": 2152164, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000072305.2", "url": "https://www.ensembl.org/id/ENSBTAT00000072305.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059613.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059613.2" } ] } }, { "isoform_ac": "F1MRN5-1", "url": "https://www.uniprot.org/uniprotkb/F1MRN5/entry", "sequence": { "sequence": "MTAWGKFESLLLALLALCAGLLTAAQGQNCGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEEDFDILSVYDGQLQQGNLKVRLSGFQLPSSIVSSGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGNPGEILKGVLHGTRFNIGDKIRYSCLSGYVLEGHAILTCIVSPGNGASWDFPAPFCRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFLEISGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELKSRGVKVMPSKDSSHKNSVLTQGGVALVSDMCPDPGIPENGRRVGSDFRVGANVQFSCEDNYVLQGSKSITCQRVTDTLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERGYDTLTVGDAGKVGDTRTVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIASPGFKAIYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECQAAFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLNCEWIIEAKPGHSIKITFDRFQTEVNYDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFSTDNSRSSVGFLIRYESVTLESDSCLDPGIPVNGHRHGSHFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCGGYIHGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSHDYLLITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYDLEPCDDPGVPAFSRRIGFHFGVGDALTFSCFPGYRLEGATKLTCLGGGRRVWSAPLPRCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRARSFQLFEGDILKVYDGKDSSSRPLGAFTRNELVGLILNSTSNHLWLEFNSNGSDTDQGFQLTYTSFDLVKCEDPGTPNYGYRIRDEGHFTDTVILYSCNPGYAMHGGGTLTCLSGDRRVWDRPLPSCVAECGGRIHAATSGRILSPGYPAPYDNNLHCTWVVEADPGKTISLHFIVFDTELAHDILRVWDGPADSAILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSVQFSTSIASTCNDPGMPQNGTRYGDSREPGDTITFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVRVNPDFVIALIFKSFNMEPSYDFLHIYEGEDSNSPLIGSFQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREACFDPGNIMNGTRIGTDFKLGSTVTYQCDSGYKIADPSSITCVIGGDGKPAWNRVLPSCNAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGTHPQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGAPARGFHFVYQAVPRTSDTQCSSVPEPRYGRRIGSEFSAGSIVRFECSPGYLLQGSTAIRCQSVPNALAQWNDTIPSCVVPCSGNFTQRRGTILSPGFPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQNWDSLEIYDGGDASAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQEPALPSNGIKTGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIATCGGTLNSMGGVVLSPGFPGTYPNNLDCTWKISLPIGYGAHIQFLNFSTEANHDYLEIQNGPYHTSPMIGQFSGPDLPSALLSTTHETLIHFYSDHSQNRPGFKLTYQAYELQNCPDPPPFQNGYMVNSDYSVGQSISFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLISVPPGHGVYINFTLLQTEAVNDYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFVLNFHAFQLKKCQPPPAVPQAEMLTEDEDFEIGDFVKYQCHPGYTLSGMDTLTCKLSSQLQFEGSLPTCEAQCPANEVRTESSGVILSPGYPGNYFNSQTCSWSIRVEPNYNITIFVDTFQSEKQFDALEVFDGSSGQSPLLVVLSGNHTEQSNFTSKSNQLYLRWSTDHATSKKGFKIRYSAPYCSLTHTVKNGGVLNRTAGEVGSKVQYFCKPGYRMIGHSNATCRRNPVGMYQWDSLAPLCQAVSCGIPESPGNGSFTGNEFTLDSKVTYDCNEGFKLDASQQATAVCQEDGFWSNRGKPPTCKPVTCPGIEAQLSEHVTWRLVSGSLNEYGAQVVLSCSPGYYLEGQRLLQCHANGTWSAGEERPRCRVISCGSLSFPPNGNKIGTLTVYGATAIFTCNSGYTLVGSHVRECLANGLWSGPETRCLAGHCGSPDPIVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGHTPVCVPITCGHPGNPAHGLTNGSEFNLNDMVNFTCNPGYLLQGASRAQCRSNGQWSSPLPTCRVVNCSDPGLVENAVRHEHQNLPEGFEYGVTVVYQCKRGFYLLGSSALTCMANGLWDRSLPKCLVISCGHPGVPANAILTGDLFTYGAVVHYSCRGSRSLVGDSSRACQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGEEFKAKSLLRFSCEMGYQLRGSAERTCLLNGSWSGLQPVCEAVSCGNPGTPTHGKIVSSDGVLFSSSVVYACWDGYRTSGLTTRHCTANGTWTGTAPDCTLISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYTMEPATSPTIRCTKDSTWNHSKPTCKAVMCGQPPPVQDGKVEGTDFRWGASISYSCAHGFQLSQPAILSCEGRGVWKGEVPQCLPVFCGDPGTPAEGRLSGKIFTYRSEVFFQCKSPFLLVGSSRRVCQADGTWSGVQPTCIDPAHNTCPDPGTPQFGIQNSSRGYEVGSMVFFRCRKGYHVQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKSKGVREVNETVTKTPVPSDVFFIHSVWKGYYEYLGKRQPATLTVDWFNATSSKVNATFTDSQGELKLTGVYKKEEAHLLLKAFQIKGPVDIFVSNFENDNWGLDGYVSSGLERGGFTFQGDIHGKDFGKFKLERQDPVSSDQDSSSHYQGTSSGSVAAAILVPFFALILSGFAFYLYKHRTRPKVQYNGYAGHENSNGQASFENPMYDTNLKPTEAKAVRFDTTLNTVCTVV", "length": 3561, "header": "tr|F1MRN5-1|F1MRN5_BOVIN Isoform 1 of CUB and Sushi multiple domains 1 OS=Bos taurus OX=9913 GN=CSMD1 PE=3 SV=4 CANONICAL=F1MRN5-1" }, "locus": { "chromosome": "27", "start_pos": 4213044, "end_pos": 2152164, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012850.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012850.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012850.7", "url": "https://www.ensembl.org/id/ENSBTAP00000012850.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2923, "start_aa": "Thr", "end_pos": 2923, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2923", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3158, "start_aa": "Thr", "end_pos": 3158, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3158", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:526825", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:526825", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MRN5", "url": "https://www.uniprot.org/uniprotkb/F1MRN5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1013, "end_pos": 1015, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1032, "end_pos": 1034, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1182, "end_pos": 1184, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1195, "end_pos": 1197, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1397, "end_pos": 1399, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1452, "end_pos": 1454, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1570, "end_pos": 1572, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1642, "end_pos": 1644, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1790, "end_pos": 1792, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1803, "end_pos": 1805, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1880, "end_pos": 1882, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2016, "end_pos": 2018, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2147, "end_pos": 2149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2152, "end_pos": 2154, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2185, "end_pos": 2187, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2356, "end_pos": 2358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2392, "end_pos": 2394, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2398, "end_pos": 2400, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2443, "end_pos": 2445, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2468, "end_pos": 2470, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2501, "end_pos": 2503, "annotation": 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"sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction. Also involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the control of actin-cytoskeleton organization.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LFM6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFM6#function" }, { "database": "UniProtKB", "id": "ARBA00058226", "url": "https://www.uniprot.org/uniprotkb/ARBA00058226#function" }, { "database": "UniProtKB", "id": "A0AAA9S963", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S963#function" }, { "database": "UniProtKB", "id": "A0AAA9SQ87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ87#function" }, { "database": "UniProtKB", "id": "F1MSR5", "url": "https://www.uniprot.org/uniprotkb/F1MSR5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MSR5", "url": "https://www.uniprot.org/uniprotkb/F1MSR5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "TBCK", "url": "https://www.uniprot.org/uniprotkb/F1MSR5", "locus": { "chromosome": "6", "start_pos": 19073436, "end_pos": 18865087, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004227", "url": "https://www.ensembl.org/id/ENSBTAG00000004227" } ] } } ], "crossref": [ { "id": "F1MSR5", "url": "https://alphafold.ebi.ac.uk/entry/F1MSR5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004227", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004227", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01525", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01525", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000195", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001763", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001763", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035969", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LFM6", "url": "https://www.orthodb.org/?gene=A0A3Q1LFM6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MSR5", "url": "https://www.orthodb.org/?gene=F1MSR5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22957", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22957", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22957:SF168", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22957:SF168", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24345", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24345", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24345:SF87", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24345:SF87", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00566", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00566", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00581", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00581", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LFM6", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LFM6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S963", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S963", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S963-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S963-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ87", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ87-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQN7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSR5", "url": "https://www.uniprot.org/uniprotkb/F1MSR5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSR5-1", "url": "https://www.uniprot.org/uniprotkb/F1MSR5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIKCWTPFVLETILLDPSGTSDYLGRFRTRRMFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERSLEDLLREGKPVSYSKVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDQKGHVKLAKFGLYHMTAYGDDVDFPIGYPSYLAPEVIAQGIFKTSDHVPSEKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTIIVLAEEHGCLDIIKELPETVIDLLKKCLTFHPSKRPTPDELMQDNVFSEVLPLYPPFIKPASLFSSSLRCADLTLPEDISQLYEDINSDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIRERDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPTSDSSGVRSSTPYFPTECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPTKKTKSSKPKLLVVDIRNSEDFVRGHISGSINIPFSTAFTAEGELTQGPYTAMLQSFKGKVIVIVGNVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTVPSPQI", "length": 924, "header": "tr|F1MSR5-1|F1MSR5_BOVIN Isoform 1 of TBC domain-containing protein kinase-like protein OS=Bos taurus OX=9913 GN=TBCK PE=3 SV=3 CANONICAL=F1MSR5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LFM6-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LFM6/entry", "sequence": { "sequence": "MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERSLEDLLREGKPVSYSKVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDQKGHVKLAKFGLYHMTAYGDDVDFPIGYPSYLAPEVIAQGIFKTSDHVPSEKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTIIVLAEEHGCLDIIKELPETVIDLLKKCLTFHPSKRPTPDELMQDNVFSEVLPLYPPFIKPASLFSSSLRCADLTLPEDISQLYEDINSDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIRERDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPTSDSSGVRSSTPYFPTECPDPPKTDLGHPSAPALSTLSHASNLDWRSVSHMSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPTKKTKSSKPKLLVVDIRNSEDFVRGHISGSINIPFSTAFTAEGELTQGPYTAMLQSFKGKVIVIVGNVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTVPSPQI", "length": 918, "header": "tr|A0A3Q1LFM6-1|F1MSR5_BOVIN Computationally mapped isoform of TBC domain-containing protein kinase-like protein OS=Bos taurus OX=9913 GN=TBCK PE=3 SV=2 CANONICAL=F1MSR5-1" }, "locus": { "chromosome": "6", "start_pos": 19072432, "end_pos": 18872806, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080873.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080873.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057007.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057007.2" } ] } }, { "isoform_ac": "A0AAA9S963-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S963/entry", "sequence": { "sequence": "MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERSLEDLLREGKPVRYPSYLAPEVIAQGIFKTSDHVPSEKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTIIVLAEEHGCLDIIKELPETVIDLLKKCLTFHPSKRPTPDELMQDNVFSEVLPLYPPFIKPASLFSSSLRCADLTLPEDISQLYEDINSDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIRERDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPTSDSSGVRSSTPYFPTECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPTKKTKSSKPKLLVVDIRNSEDFVRGHISGSINIPFSTAFTAEGELTQGPYTAMLQSFKGKVIVIVGNVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTVPSPQI", "length": 830, "header": "tr|A0AAA9S963-1|F1MSR5_BOVIN Computationally mapped isoform of TBC domain-containing protein kinase-like protein OS=Bos taurus OX=9913 GN=TBCK PE=3 SV=1 CANONICAL=F1MSR5-1" }, "locus": { "chromosome": "6", "start_pos": 19072432, "end_pos": 18872806, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127240.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127240.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079923.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079923.1" } ] } }, { "isoform_ac": "A0AAA9SQ87-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ87/entry", "sequence": { "sequence": "MSDSVQPHRRQPTRLPCPWDFPGKNTGVGCHFLLQCMKVKSESEVSQSCPTLSNPMDRSLPGSSIHGIFQGHVKLAKFGLYHMTAYGDDVDFPIGYPSYLAPEVIAQGIFKTSDHVPSEKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTIIVLAEEHGCLDIIKELPETVIDLLKKCLTFHPSKRPTPDELMQDNVFSEVLPLYPPFIKPASLFSSSLRCADLTLPEDISQLYEDINSDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIRERDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPTSDSSGVRSSTPYFPTECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPTKKTKSSKPKLLVVDIRNSEDFVRGHISGSINIPFSTAFTAEGELTQGPYTAMLQSFKGKVIVIVGNVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTVPSPQI", "length": 836, "header": "tr|A0AAA9SQ87-1|F1MSR5_BOVIN Computationally mapped isoform of TBC domain-containing protein kinase-like protein OS=Bos taurus OX=9913 GN=TBCK PE=3 SV=1 CANONICAL=F1MSR5-1" }, "locus": { "chromosome": "6", "start_pos": 19072432, "end_pos": 18916716, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112265.2", "url": "https://www.ensembl.org/id/ENSBTAT00000112265.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085100.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085100.1" } ] } }, { "isoform_ac": "A0AAA9SQN7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQN7/entry", "sequence": { "sequence": "MFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERSLEDLLREGKPVSYSKVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDQKGHVKLAKFGLYHMTAYGDDVDFPIGYPSYLAPEVIAQGIFKTSDHVPSEKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTIIVLAEEHGCLDIIKELPETVIDLLKKCLTFHPSKRPTPDELMQDNVFSEVLPLYPPFIKPASLFSSSLRCADLTLPEDISQLYEDINSDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIRERDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPTSDSSGVRSSTPYFPTECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPTKKTKSSKPKLLVVDIRNSEDFVRGHISGSINIPFSTAFTAEGELTQGPYTAMLQSFKGKVIVIVGNVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTVPSPQI", "length": 865, "header": "tr|A0AAA9SQN7-1|F1MSR5_BOVIN Computationally mapped isoform of TBC domain-containing protein kinase-like protein OS=Bos taurus OX=9913 GN=TBCK PE=3 SV=1 CANONICAL=F1MSR5-1" }, "locus": { "chromosome": "6", "start_pos": 19072432, "end_pos": 18872806, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135550.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135550.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086261.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086261.1" } ] } }, { "isoform_ac": "F1MSR5-1", "url": "https://www.uniprot.org/uniprotkb/F1MSR5/entry", "sequence": { "sequence": "MIKCWTPFVLETILLDPSGTSDYLGRFRTRRMFPLKDAEMGAFTFFASALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERSLEDLLREGKPVSYSKVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDQKGHVKLAKFGLYHMTAYGDDVDFPIGYPSYLAPEVIAQGIFKTSDHVPSEKPLPSGPKSDVWSLGIILFELCVGRKLFQSLDISERLKFLLTLDCVDDTIIVLAEEHGCLDIIKELPETVIDLLKKCLTFHPSKRPTPDELMQDNVFSEVLPLYPPFIKPASLFSSSLRCADLTLPEDISQLYEDINSDYLAERSIEEVYYLWCLAGGDLEKELVNKEIIRSKPPICTLPNFLFEDGESFGQGRDRSSLLDDTTVTLSLCQLRNRLKDVGGEAFYPLLEDDQSNLPHSNSNNELSAAATLPLIIRERDTEYQLNRIILFDRLLKAYPYKKNQIWKEARVDIPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECILLFSDLPEIDIERCVRESINLFCWTPKSATYRQHAQPPKPTSDSSGVRSSTPYFPTECPDPPKTDLSRESIPLNDLKSEVSPRISAEDLIDLCELTVTGHFKTPTKKTKSSKPKLLVVDIRNSEDFVRGHISGSINIPFSTAFTAEGELTQGPYTAMLQSFKGKVIVIVGNVAKHTAEFAAHLVKMKYPRICILDGGINKIKPTGLLTVPSPQI", "length": 924, "header": "tr|F1MSR5-1|F1MSR5_BOVIN Isoform 1 of TBC domain-containing protein kinase-like protein OS=Bos taurus OX=9913 GN=TBCK PE=3 SV=3 CANONICAL=F1MSR5-1" }, "locus": { "chromosome": "6", "start_pos": 19072432, "end_pos": 18871394, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005539.8", "url": "https://www.ensembl.org/id/ENSBTAT00000005539.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005539.6", "url": "https://www.ensembl.org/id/ENSBTAP00000005539.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "F1MSR5", "url": "https://www.uniprot.org/uniprotkb/F1MSR5" } ], "pmid": "" }, { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "F1MSR5", "url": "https://www.uniprot.org/uniprotkb/F1MSR5" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MSR5", "url": "https://www.uniprot.org/uniprotkb/F1MSR5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F1MSR5", "url": "https://www.uniprot.org/uniprotkb/F1MSR5" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "F1MSR5", "url": "https://www.uniprot.org/uniprotkb/F1MSR5" } ], "pmid": "" }, { "name": "midbody", "id": "GO:0030496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496", "evidence": [ { "database": "UniProtKB", "id": "F1MSR5", "url": "https://www.uniprot.org/uniprotkb/F1MSR5" } ], "pmid": "" }, { "name": "mitotic spindle", "id": "GO:0072686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "evidence": [ { "database": "UniProtKB", "id": "F1MSR5", "url": "https://www.uniprot.org/uniprotkb/F1MSR5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell population proliferation", "id": "GO:0008283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "database": "UniProtKB", "id": "F1MSR5", "url": "https://www.uniprot.org/uniprotkb/F1MSR5" } ], "pmid": "" }, { "name": "actin cytoskeleton organization", "id": "GO:0030036", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "evidence": [ { "database": "UniProtKB", "id": "F1MSR5", "url": "https://www.uniprot.org/uniprotkb/F1MSR5" } ], "pmid": "" }, { "name": "regulation of TOR signaling", "id": "GO:0032006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032006", "evidence": [ { "database": "UniProtKB", "id": "F1MSR5", "url": "https://www.uniprot.org/uniprotkb/F1MSR5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 682, "end_pos": 684, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MSR5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 924, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MSR5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MSR5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MSR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSR5" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 12, "end_pos": 304, "start_aa": "Thr", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MSR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSR5" }, { "id": "PS50086", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50086" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rab-GAP TBC", "eco_id": "ECO_0000259", "start_pos": 497, "end_pos": 682, "start_aa": "Asp", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MSR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSR5" }, { "id": "PS50206", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50206" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rhodanese", "eco_id": "ECO_0000259", "start_pos": 821, "end_pos": 920, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 682, "end_pos": 684 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MLK4-1", "uniprot_ac": "F1MLK4", "uniprot_id": "F1MLK4_BOVIN", "mass": { "chemical_mass": 113646.0, "monoisotopic_mass": 113646.0 }, "refseq": { "ac": "XP_024856717", "name": "protein AF-10 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856717" }, "gene_names": [ { "name": "MLLT10", "type": "recommended", "evidence": [ { "id": "F1MLK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLK4" } ] }, { "name": "MLLT10", "type": "synonym", "evidence": [ { "id": "XP_024856717", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856717" } ] } ], "protein_names": [ { "name": "MLLT10 histone lysine methyltransferase DOT1L cofactor", "type": "synonym", "evidence": [ { "id": "F1MLK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLK4/entry#names_and_taxonomy" } ] }, { "name": "protein AF-10 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024856717", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856717" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MLK4", "url": "https://www.uniprot.org/uniprotkb/F1MLK4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MLLT10", "url": "https://www.uniprot.org/uniprotkb/F1MLK4", "locus": { "chromosome": "13", "start_pos": 22955677, "end_pos": 22748046, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000044074", "url": "https://www.ensembl.org/id/ENSBTAG00000044074" } ] } } ], "crossref": [ { "id": "F1MLK4", "url": "https://alphafold.ebi.ac.uk/entry/F1MLK4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000044074", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000044074", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15574", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15574", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15708", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15708", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20901", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20901", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "519864", "url": "https://www.ncbi.nlm.nih.gov/gene/519864", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "XTCYICD", "url": "https://omabrowser.org/oma/group/XTCYICD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR13793", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13793", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13793:SF93", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13793:SF93", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13831", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13831", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13832", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13832", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024856717", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856717", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKM7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKM7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LKM7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKM7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0N4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0N4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0N4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0N4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T945", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T945", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T945-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T945-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLK4", "url": "https://www.uniprot.org/uniprotkb/F1MLK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLK4-1", "url": "https://www.uniprot.org/uniprotkb/F1MLK4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSSNSISGSLKRLEDTAARFTNANFQEVSAHTTSAKDVSEARGSEGKGKKSSAHSSGQRGRKPGGRNPGTTVSAASPFQQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYTHSQQSSSTKDVHKGESGSQEGGVNSFSSIIGLPSASAVISQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSVTSSSLQKSPTPLRNGSVQSLSVGSSPLGSEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQPSGHLQQVGALSPSAGSSAPSAVAATQANTLSGSSLNQASSHMYGNRLNSTSSMAALIAQSENNQTDQDLGDNSRSLAGRGSSPRGSLSPRSPVSNLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQMHAFPAQNAPTTDSLNSSKSPHLGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMPTVTSTIPAVPGVGGIIGALPGNQLAINGIVGALNGVIQTPVTISQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQIFLHQQQFQQLLNSQQLTPEQHQALLYQLVQQHHQQQQQHHQPDLQQLQIPGPTQIPINNLLAGTQAPPLHPATTNPFLTIHGDNASQKVTRLSDKSGPVAQEKS", "length": 1072, "header": "tr|F1MLK4-1|F1MLK4_BOVIN Isoform 1 of MLLT10 histone lysine methyltransferase DOT1L cofactor OS=Bos taurus OX=9913 GN=MLLT10 PE=4 SV=3 CANONICAL=F1MLK4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LKM7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKM7/entry", "sequence": { "sequence": "MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSSNSISGSLKRLEDTAARFTNANFQEVSAHTTSAKDVSEARGSEGKGKKSSAHSSGQRGRKPGGRNPGTTVSAASPFQQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYTHSQQSSSTKDVHKGESGSQEGGVNSFSSIIGLPSASAVISQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSVTSSSLQKSPTPLRNGSVQSLSVGSSPLGSGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQPSGHLQQVGALSPSAGSSAPSAVAATQANTLSGSSLNQASSHMYGNRLNSTSSMAALIAQSENNQTDQDLGDNSRSLAGRGSSPRGSLSPRSPVSNLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQMHAFPAQNAPTTDSLNSSKSPHLGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMPTVTSTIPAVPGVGGIIGALPGNQLAINGIVGALNGVIQTPVTISQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQIFLHQQQFQQLLNSQQLTPEQHQALLYQLVQQHHQQQQQHHQPDLQQLQIPGPTQIPINNLLAGTQAPPLHPATTNPFLTIHGDNASQKVTRLSDKSGPVAQEKS", "length": 1046, "header": "tr|A0A3Q1LKM7-1|F1MLK4_BOVIN Computationally mapped isoform of MLLT10 histone lysine methyltransferase DOT1L cofactor OS=Bos taurus OX=9913 GN=MLLT10 PE=4 SV=1 CANONICAL=F1MLK4-1" }, "locus": { "chromosome": "13", "start_pos": 22953986, "end_pos": 22748046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080146.3", "url": "https://www.ensembl.org/id/ENSBTAT00000080146.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057027.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057027.1" } ] } }, { "isoform_ac": "A0A3Q1M0N4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0N4/entry", "sequence": { "sequence": "MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSSNSISGSLKRLEDTAARFTNANFQEVSAHTTSAKDVSEARGSEGKGKKSSAHSSGQRGRKPGGRNPGTTVSAASPFQQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYTHSQQSSSTKDVHKGESGSQEGGVNSFSSIIGLPSASAVISQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSVTSSSLQKSPTPLRNGSVQSLSVGSSPLGSEISMQYRHDGACPTTSIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQPSGHLQQVGALSPSAGSSAPSAVAATQANTLSGSSLNQASSHMYGNRLNSTSSMAALIAQSENNQTDQDLGDNSRSLAGRGSSPRGSLSPRSPVSNLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQMHAFPAQNAPTTDSLNSSKSPHLGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMPTVTSTIPAVPGVGGIIGALPGNQLAINGIVGALNGVIQTPVTISQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQIFLHQQQFQQLLNSQQLTPEQHQALLYQLVQQHHQQQQQHHQPDLQQLQIPGPTQIPINNLLAGTQAPPLHPATTNPFLTIHGDNASQKVTRLSDKSGPVAQEKS", "length": 1061, "header": "tr|A0A3Q1M0N4-1|F1MLK4_BOVIN Computationally mapped isoform of MLLT10 histone lysine methyltransferase DOT1L cofactor OS=Bos taurus OX=9913 GN=MLLT10 PE=4 SV=1 CANONICAL=F1MLK4-1" }, "locus": { "chromosome": "13", "start_pos": 22953986, "end_pos": 22748046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000075565.3", "url": "https://www.ensembl.org/id/ENSBTAT00000075565.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063217.1", "url": "https://www.ensembl.org/id/ENSBTAP00000063217.1" } ] } }, { "isoform_ac": "A0AAA9T945-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T945/entry", "sequence": { "sequence": "MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSSNSISGSLKRLEDTAARFTNANFQEVSAHTTSAKDVSEARGSEGKGKKSSAHSSGQRGRKPGGRNPGTTVSAASPFQQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYTHSQQSSSTKDVHKGESGSQEGGVNSFSSIIGLPSASAVISQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSVTSSSLQKSPTPLRNGSVQSLSVGSSPLGSEISMQYRHDGACPTTTFSELLNAIHNDNVDSFILTEQELKFIGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQPSGHLQQVGALSPSAGSSAPSAVAATQANTLSGSSLNQASSHMYGNRLNSTSSMAALIAQSENNQTDQDLGDNSRSLAGRGSSPRGSLSPRSPVSNLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQMHAFPAQNAPTTDSLNSSKSPHLGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMPTVTSTIPAVPGVGGIIGALPGNQLAINGIVGALNGVIQTPVTISQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQIFLHQQQFQQLLNSQQLTPARRRLHFTQPPPTRSSPSMVIMQVRR", "length": 1028, "header": "tr|A0AAA9T945-1|F1MLK4_BOVIN Computationally mapped isoform of MLLT10 histone lysine methyltransferase DOT1L cofactor OS=Bos taurus OX=9913 GN=MLLT10 PE=4 SV=1 CANONICAL=F1MLK4-1" }, "locus": { "chromosome": "13", "start_pos": 22952272, "end_pos": 22748046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131775.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131775.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094519.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094519.1" } ] } }, { "isoform_ac": "F1MLK4-1", "url": "https://www.uniprot.org/uniprotkb/F1MLK4/entry", "sequence": { "sequence": "MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSSNSISGSLKRLEDTAARFTNANFQEVSAHTTSAKDVSEARGSEGKGKKSSAHSSGQRGRKPGGRNPGTTVSAASPFQQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYTHSQQSSSTKDVHKGESGSQEGGVNSFSSIIGLPSASAVISQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSVTSSSLQKSPTPLRNGSVQSLSVGSSPLGSEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQPSGHLQQVGALSPSAGSSAPSAVAATQANTLSGSSLNQASSHMYGNRLNSTSSMAALIAQSENNQTDQDLGDNSRSLAGRGSSPRGSLSPRSPVSNLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQMHAFPAQNAPTTDSLNSSKSPHLGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMPTVTSTIPAVPGVGGIIGALPGNQLAINGIVGALNGVIQTPVTISQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQIFLHQQQFQQLLNSQQLTPEQHQALLYQLVQQHHQQQQQHHQPDLQQLQIPGPTQIPINNLLAGTQAPPLHPATTNPFLTIHGDNASQKVTRLSDKSGPVAQEKS", "length": 1072, "header": "tr|F1MLK4-1|F1MLK4_BOVIN Isoform 1 of MLLT10 histone lysine methyltransferase DOT1L cofactor OS=Bos taurus OX=9913 GN=MLLT10 PE=4 SV=3 CANONICAL=F1MLK4-1" }, "locus": { "chromosome": "13", "start_pos": 22953986, "end_pos": 22748046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061645.5", "url": "https://www.ensembl.org/id/ENSBTAT00000061645.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053600.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053600.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1021, "start_aa": "Thr", "end_pos": 1021, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1021", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 355, "start_aa": "Thr", "end_pos": 355, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr355", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZT80-1", "protein_name": "MLLT10, histone lysine methyltransferase DOT1L cofactor", "gene_name": "Mllt10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRAPGPRGEGRPTSRPSRAPEPSGRLTPAALGSRLRSSPTSAHLGAAERCGGGESLEMVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKPKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTAARFTNANFQEVSAHTSSGKDVSEARSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSASSPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYTHTQPPPSTKDVHKGEPGSQDAGVNSFSSLVGHPGTSGATSQPKSFDSSPGELGSSSLPTAGYKRAQTSGVEEEEAVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSVTSCSLQKSPTLLRNGSMQSLSVGSSPLGSEISMQYRHDGACPTTSIYNSNDVAVSFPNVVSGSGSSTPVSSSHIPQQSSGHLQQVGALSPSAASSVTPAAATTQANTAPGSSLSQAPAHVYGSRLNQNPSMAVLIAQSESSQTDQDLGDNTRSLVGRGSSPRGSLSPRSPVSNLQIRYDQPSSSGLESLPPVAVSIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPAITTNPSPSHQIHTYTAQTAPTTDSLNSSKSPHIGNSFVPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGPLASGMQTVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVIQTPVTISQNPAPLTHTSVPPNAAHPMPAAALTNSASGLGLLSDQQRQMFLQQQQFQQLLNSQQLTPEQHQAFLYQLMQQQHHPPELQQMQLPGPTQIPINNLLAGPPAPPLHTATTNPFLTIHGDSTSQKVTRLSDKTGPVAQEKS", "length": 1114 }, "evidence": [ { "id": "F1MLK4", "url": "https://omabrowser.org/oma/group/F1MLK4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O54826-1", "protein_name": "Protein AF-10", "gene_name": "Mllt10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYEQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTAARFTNANFQEVSAHTSSGKDVSEARGSEGKGKKSSAHSSGQRGRKPGAGRNPGTAVSASSPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRSDSYTHTQQPSSTKDVHKGESGSQEAAVNSFSSLVGHPVTSTVISQPKSFDNSPGELGSSSLPTAGYKRAQTSGIEEEAVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSVTSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHIPQQSSGHLQQVGALSPSAASSVTPAAATTQANTVSGSSLSQAPAHMYGSRLNQNPSMAVLIAQSESSQTDQDLGDNARSLGGRGSSPRGSLSPRSPVSNLQLRYDQPSNSSLETVPPVAASIEQLLERQWSEGQQFLLEQGTPGDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPAITTNPSPSHQMHTYTAQTAPPPDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQSSGVSGVQQVNGVTVGALASGMQTVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVIQTPVTISQNPAPLTHTSVPPNAAHPMPAAALTNSASGLGLLSDQQRQMFIQQQQFQQLLNSQQLTPEQHQAFLYQLMQQQHHPPELQQLQLPGPTQIPINNLLAGAQAPPLHTATTNPFLTIHGDSTSQKVTRLSDKTGPVAQEKS", "length": 1068 }, "evidence": [ { "id": "F1MLK4", "url": "https://omabrowser.org/oma/group/F1MLK4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P55197-4", "protein_name": "Protein AF-10", "gene_name": "MLLT10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANTLSGSSLSQAPSHMYGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNSQQLTPEQHQAFLYQLMQHHHQQHHQPELQQLQIPGPTQIPINNLLAGTQAPPLHTATTNPFLTIHGDNASQKVARLSDKTGPVAQEKS", "length": 1068 }, "evidence": [ { "id": "F1MLK4", "url": "https://omabrowser.org/oma/group/F1MLK4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MLK4", "url": "https://www.uniprot.org/uniprotkb/F1MLK4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MLK4", "url": "https://www.uniprot.org/uniprotkb/F1MLK4" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "F1MLK4", "url": "https://www.uniprot.org/uniprotkb/F1MLK4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MLK4", "url": "https://www.uniprot.org/uniprotkb/F1MLK4" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "F1MLK4", "url": "https://www.uniprot.org/uniprotkb/F1MLK4" } ], "pmid": "" }, { "name": "nucleosome binding", "id": "GO:0031491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031491", "evidence": [ { "database": "UniProtKB", "id": "F1MLK4", "url": "https://www.uniprot.org/uniprotkb/F1MLK4" } ], "pmid": "" }, { "name": "histone reader activity", "id": "GO:0140566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140566", "evidence": [ { "database": "UniProtKB", "id": "F1MLK4", "url": "https://www.uniprot.org/uniprotkb/F1MLK4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1MLK4", "url": "https://www.uniprot.org/uniprotkb/F1MLK4" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "F1MLK4", "url": "https://www.uniprot.org/uniprotkb/F1MLK4" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MLK4", "url": "https://www.uniprot.org/uniprotkb/F1MLK4" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1MLK4", "url": "https://www.uniprot.org/uniprotkb/F1MLK4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1052, "end_pos": 1054, "annotation": "n_glycosylation_sequon" }, { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 383, "end_pos": 385, "annotation": "n_glycosylation_sequon" }, { "start_pos": 441, "end_pos": 443, "annotation": "n_glycosylation_sequon" }, { "start_pos": 488, "end_pos": 490, "annotation": "n_glycosylation_sequon" }, { "start_pos": 524, "end_pos": 526, "annotation": "n_glycosylation_sequon" }, { "start_pos": 647, "end_pos": 649, "annotation": "n_glycosylation_sequon" }, { "start_pos": 662, "end_pos": 664, "annotation": "n_glycosylation_sequon" }, { "start_pos": 704, "end_pos": 706, "annotation": "n_glycosylation_sequon" }, { "start_pos": 764, "end_pos": 766, "annotation": "n_glycosylation_sequon" }, { "start_pos": 811, "end_pos": 813, "annotation": "n_glycosylation_sequon" }, { "start_pos": 942, "end_pos": 944, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MLK4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1072, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MLK4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MLK4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MLK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLK4" }, { "id": "PS50016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50016" }, { "id": "PS51805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PHD-type", "eco_id": "ECO_0000259", "start_pos": 22, "end_pos": 74, "start_aa": "Ile", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 355, 1021 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1052, "end_pos": 1054 }, { "start_pos": 116, "end_pos": 118 }, { "start_pos": 134, "end_pos": 136 }, { "start_pos": 209, "end_pos": 211 }, { "start_pos": 383, "end_pos": 385 }, { "start_pos": 441, "end_pos": 443 }, { "start_pos": 488, "end_pos": 490 }, { "start_pos": 524, "end_pos": 526 }, { "start_pos": 647, "end_pos": 649 }, { "start_pos": 662, "end_pos": 664 }, { "start_pos": 704, "end_pos": 706 }, { "start_pos": 764, "end_pos": 766 }, { "start_pos": 811, "end_pos": 813 }, { "start_pos": 942, "end_pos": 944 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MU04-1", "uniprot_ac": "F1MU04", "uniprot_id": "F1MU04_BOVIN", "mass": { "chemical_mass": 34252.0, "monoisotopic_mass": 34252.0 }, "refseq": { "ac": "NP_001179183", "name": "solute carrier family 25 member 36", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179183" }, "gene_names": [ { "name": "SLC25A36", "type": "recommended", "evidence": [ { "id": "F1MU04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU04" } ] }, { "name": "SLC25A36", "type": "synonym", "evidence": [ { "id": "NP_001179183", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179183" } ] } ], "protein_names": [ { "name": "Solute carrier family 25 member 36", "type": "synonym", "evidence": [ { "id": "F1MU04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU04/entry#names_and_taxonomy" } ] }, { "name": "solute carrier family 25 member 36", "type": "synonym", "evidence": [ { "id": "NP_001179183", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179183" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MU04", "url": "https://www.uniprot.org/uniprotkb/F1MU04" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC25A36", "url": "https://www.uniprot.org/uniprotkb/F1MU04", "locus": { "chromosome": "1", "start_pos": 128010259, "end_pos": 128042610, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015310", "url": "https://www.ensembl.org/id/ENSBTAG00000015310" } ] } } ], "crossref": [ { "id": "F1MU04", "url": "https://alphafold.ebi.ac.uk/entry/F1MU04", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015310", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015310", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "510392", "url": "https://www.ncbi.nlm.nih.gov/gene/510392", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018108", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018108", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023395", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023395", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510392", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510392", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WVMYEQM", "url": "https://omabrowser.org/oma/group/WVMYEQM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LLP7", "url": "https://www.orthodb.org/?gene=A0A3Q1LLP7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MU04", "url": "https://www.orthodb.org/?gene=F1MU04", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45829:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45829:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00153", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00153", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179183", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "73531", "url": "https://www.rhea-db.org/rhea/73531", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LLP7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLP7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MU04", "url": "https://www.uniprot.org/uniprotkb/F1MU04", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MU04-1", "url": "https://www.uniprot.org/uniprotkb/F1MU04-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLSTMAGASVNRVVSPGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNGLFDPDSTQVHMISAAMAGFTAITATNPIWLIKTRLQLDARNRGEKRMGAFECVRKVYQTDGLRGFYRGMSASYAGISETVIHFVIYESIKQKLLEYKIASTMENEEESVKEVSDFVGMMLAAATSKTCATSIAYPHEVVRTRLREEGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMATYELVVYLLNG", "length": 311, "header": "tr|F1MU04-1|F1MU04_BOVIN Isoform 1 of Solute carrier family 25 member 36 OS=Bos taurus OX=9913 GN=SLC25A36 PE=3 SV=2 CANONICAL=F1MU04-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLP7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLP7/entry", "sequence": { "sequence": "MSQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLSTMAGASVNRVVSPGPLHCLKAIYFAAYSNCKEKLNGLFDPDSTQVHMISAAMAGFTAITATNPIWLIKTRLQLDARNRGEKRMGAFECVRKVYQTDGLRGFYRGMSASYAGISETVIHFVIYESIKQKLLEYKIASTMENEEESVKEVSDFVGMMLAAATSKTCATSIAYPHEVVRTRLREEGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMATYELVVYLLNG", "length": 285, "header": "tr|A0A3Q1LLP7-1|F1MU04_BOVIN Computationally mapped isoform of Solute carrier family 25 member 36 OS=Bos taurus OX=9913 GN=SLC25A36 PE=3 SV=1 CANONICAL=F1MU04-1" }, "locus": { "chromosome": "1", "start_pos": 128042419, "end_pos": 128010285, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000080638.2", "url": "https://www.ensembl.org/id/ENSBTAT00000080638.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057704.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057704.1" } ] } }, { "isoform_ac": "F1MU04-1", "url": "https://www.uniprot.org/uniprotkb/F1MU04/entry", "sequence": { "sequence": "MSQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLSTMAGASVNRVVSPGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNGLFDPDSTQVHMISAAMAGFTAITATNPIWLIKTRLQLDARNRGEKRMGAFECVRKVYQTDGLRGFYRGMSASYAGISETVIHFVIYESIKQKLLEYKIASTMENEEESVKEVSDFVGMMLAAATSKTCATSIAYPHEVVRTRLREEGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMATYELVVYLLNG", "length": 311, "header": "tr|F1MU04-1|F1MU04_BOVIN Isoform 1 of Solute carrier family 25 member 36 OS=Bos taurus OX=9913 GN=SLC25A36 PE=3 SV=2 CANONICAL=F1MU04-1" }, "locus": { "chromosome": "1", "start_pos": 128042419, "end_pos": 128010285, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020353.7", "url": "https://www.ensembl.org/id/ENSBTAT00000020353.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020353.5", "url": "https://www.ensembl.org/id/ENSBTAP00000020353.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510392", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510392", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2R7Y0-1", "protein_name": "Solute carrier family 25 member 36", "gene_name": "SLC25A36", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVHLNTMAGASVNRVVSPGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNGLFDPDSTQVHMISAAMAGFTAITATNPIWLIKTRLQLDARNRGEKRMGAFECVRKVYQTDGLRGFYRGMSASYAGISETVIHFVIYESIKQKLLEYKIASTMETEEESVKEASDFVGMMLAAATSKTCATTIAYPHEVVRTRLREEGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMATYELVVYLLNG", "length": 311 }, "evidence": [ { "id": "F1MU04", "url": "https://omabrowser.org/oma/group/F1MU04/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4ACN9-1", "protein_name": "Solute carrier family 25 member 36", "gene_name": "Slc25a36", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNGVFDPDSTQVHMISAAMAGFTAITATNPIWLIKTRLQLDARNRGEKRMGAFECVRKVYQTDGLRGFYRGMSASYAGISETVIHFVIYESIKQKLLECKTASMMETDEESVKEASDFVRMMLAAATSKTCATTVAYPHEVVRTRLREEGTKYRSFFQTLSLIVQEEGYGSLYRGLTTHLVRQIPNTAIMMATYELVVYLLNG", "length": 311 }, "evidence": [ { "id": "F1MU04", "url": "https://omabrowser.org/oma/group/F1MU04/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P38127-1", "protein_name": "Mitochondrial pyrimidine nucleotide transporter RIM2", "gene_name": "RIM2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MPKKSIEEWEEDAIESVPYLASDEKGSNYKEATQIPLNLKQSEIENHPTVKPWVHFVAGGIGGMAGAVVTCPFDLVKTRLQSDIFLKAYKSQAVNISKGSTRPKSINYVIQAGTHFKETLGIIGNVYKQEGFRSLFKGLGPNLVGVIPARSINFFTYGTTKDMYAKAFNNGQETPMIHLMAAATAGWATATATNPIWLIKTRVQLDKAGKTSVRQYKNSWDCLKSVIRNEGFTGLYKGLSASYLGSVEGILQWLLYEQMKRLIKERSIEKFGYQAEGTKSTSEKVKEWCQRSGSAGLAKFVASIATYPHEVVRTRLRQTPKENGKRKYTGLVQSFKVIIKEEGLFSMYSGLTPHLMRTVPNSIIMFGTWEIVIRLLS", "length": 377 }, "evidence": [ { "id": "F1MU04", "url": "https://omabrowser.org/oma/group/F1MU04/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54Z02-1", "protein_name": "Mitochondrial substrate carrier family protein", "gene_name": "rimA", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFPTFINYTTLSVPNSIQIPNNLNNINNIINIQNNNNNINNNNNNNNRKKRSKNALLHFIAGGIGGAAGVICTSPLEVIKTQLQAKNSNLLVKDKPRFVPTTAYSLYHLVKRDGKSGLWKGLGAHLLGVAPARAIHFSSYSFTKSIMNKLGYTDGPILWITSAVSSGAAVAITTSPIWLIKTRMQLQTSLKNFNEGTQYRGMFHCCLSILREEGPLGFYKGLGASLISVSESAFQFVLYEGFKNRIITEKRLKGYENPNELSTSEYLISAGIAKLIAAITTYPHEVVRTRLREQTKPGVKSKYTGVIQGLTLIAREEGIRGLFGGAGPHIIRVVPNSCIMFLTYELVLDIAHGVSLLFDTNHYRQ", "length": 365 }, "evidence": [ { "id": "F1MU04", "url": "https://omabrowser.org/oma/group/F1MU04/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5ZKP7-1", "protein_name": "Solute carrier family 25 member 36", "gene_name": "SLC25A36", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVHLNTVNGASVNRVTRVSPGPLHCLKMILQKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNNIFNPDSTQVHMISAGVAGFTAITMTNPIWLVKTRLQLDARNRGEKRMSAFECVRKVYRSDGIKGFYRGMSASYAGISETVIHFVIYESIKRKLLEHKTASAMDSEDESAKEASDFVGMMMAAATSKTCATSIAYPHEVVRTRLREEGTKYRSFFQTLSLLVREEGYGSLYRGLTTHLVRQIPNTAIMMSTYEVVVYLLDG", "length": 313 }, "evidence": [ { "id": "F1MU04", "url": "https://omabrowser.org/oma/group/F1MU04/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6DG32-1", "protein_name": "Solute carrier family 25 member 36-A", "gene_name": "slc25a36a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTFYISEVQLSTVNGASVARMAPPGPLHCLKLILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSTSKEKLNNVFDPDSTQVHMLSAGLAGFTAITATNPIWLIKTRLQLDARNRGERRMSAFECVRRVYQSDGLRGFYRGMSASYAGISETVIHFVIYESIKRKLIEHKANSNMDDEDESVKDASDFVGMMLAAATSKTCATSIAYPHEVIRTRLREEGSKYRSFFQTLNMVFREEGYRALYRGLTTHLVRQIPNTAIMMCTYELVVYLLNG", "length": 311 }, "evidence": [ { "id": "F1MU04", "url": "https://omabrowser.org/oma/group/F1MU04/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q7XA87-1", "protein_name": "Folate transporter 1, chloroplastic", "gene_name": "FOLT1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAASWQWENATAGAVAGFATVAAMHSLDVVRTRFQVNDGRGSSLPTYKNTAHAVFTIARLEGLRGLYAGFFPAVIGSTVSWGLYFFFYGRAKQRYARGRDDEKLSPALHLASAAEAGALVCLCTNPIWLVKTRLQLQTPLHQTQPYSGLLDAFRTIVKEEGPRALYKGIVPGLVLVSHGAIQFTAYEELRKIIVDLKERRRKSESTDNLLNSADYAALGGSSKVAAVLLTYPFQVIRARLQQRPSTNGIPRYIDSLHVIRETARYEGLRGFYRGLTANLLKNVPASSITFIVYENVLKLLKQHPTTKD", "length": 308 }, "evidence": [ { "id": "F1MU04", "url": "https://omabrowser.org/oma/group/F1MU04/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q922G0-1", "protein_name": "Solute carrier family 25 member 36", "gene_name": "Slc25a36", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLHCLKAILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNGVFDPDSTQVHMASAAMAGFTAITATNPIWLIKTRLQLDARTRGEKQMGAFECVRKVYQTDGLRGFYRGMSASYAGISETVIHFVIYESIKQKLLECKTASMMETDEESVKEASDFVRMMLAAATSKTCATTIAYPHEVVRTRLREEGTKYRSFFQTLSLIVQEEGYGSLYRGLTTHLVRQIPNTAIMMATYELVVYLLNG", "length": 311 }, "evidence": [ { "id": "F1MU04", "url": "https://omabrowser.org/oma/group/F1MU04/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96CQ1-1", "protein_name": "Solute carrier family 25 member 36", "gene_name": "SLC25A36", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDSTQVHMISAAMAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMSASYAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTCATTIAYPHEVVRTRLREEGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMATYELVVYLLNG", "length": 311 }, "evidence": [ { "id": "F1MU04", "url": "https://omabrowser.org/oma/group/F1MU04/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VQ37-1", "protein_name": "Mitochondrial carrier protein Rim2", "gene_name": "Rim2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAQNTADTLIHLIAGGSAGTVGAVVTCPLEVVKTRLQSSTAFMTPSRLAENAGGGPANGGQSELLRPEQRRKLSTTILRNRSQPQVIGGVRRIMAISHCGISSTTPKSMSIVQCLRHIVQNEGPRALFKGLGPNLVGVAPSRAIYFCTYSQTKNTLNSLGFVERDSPLVHIMSAASAGFVSSTATNPIWFVKTRMQLDYNSKVQMTVRQCIERVYAQGGVAAFYKGITASYFGICETMVHFVIYEFIKSKLLEQRNQRHTDTKGSRDFLEFMMAGAVSKTIASCIAYPHEVARTRLREEGNKYNSFWQTLHTVWKEEGRAGLYRGLATQLVRQIPNTAIMMATYEAVVYVLTRRFNNKSNEFYDF", "length": 365 }, "evidence": [ { "id": "F1MU04", "url": "https://omabrowser.org/oma/group/F1MU04/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "F1MU04", "url": "https://www.uniprot.org/uniprotkb/F1MU04" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1MU04", "url": "https://www.uniprot.org/uniprotkb/F1MU04" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "pyrimidine nucleotide transmembrane transporter activity", "id": "GO:0015218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015218", "evidence": [ { "database": "UniProtKB", "id": "F1MU04", "url": "https://www.uniprot.org/uniprotkb/F1MU04" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "pyrimidine nucleotide import into mitochondrion", "id": "GO:1990519", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990519", "evidence": [ { "database": "UniProtKB", "id": "F1MU04", "url": "https://www.uniprot.org/uniprotkb/F1MU04" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "73531", "name": "", "equation": "UTP(in) + CTP(out) = UTP(out) + CTP(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "73531", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/73531" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MU04-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 311, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MU04-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MU04" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MPF7-1", "uniprot_ac": "F1MPF7", "uniprot_id": "F1MPF7_BOVIN", "mass": { "chemical_mass": 204681.0, "monoisotopic_mass": 204681.0 }, "refseq": {}, "gene_names": [ { "name": "PHIP", "type": "recommended", "evidence": [ { "id": "F1MPF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF7" } ] } ], "protein_names": [ { "name": "PH-interacting protein", "type": "recommended", "evidence": [ { "id": "F1MPF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF7/entry#names_and_taxonomy" } ] }, { "name": "IRS-1 PH domain-binding protein", "type": "synonym", "evidence": [ { "id": "F1MPF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF7/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 11", "type": "synonym", "evidence": [ { "id": "F1MPF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LLQ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLQ0#function" }, { "database": "UniProtKB", "id": "ARBA00058276", "url": "https://www.uniprot.org/uniprotkb/ARBA00058276#function" }, { "database": "UniProtKB", "id": "F1MPF7", "url": "https://www.uniprot.org/uniprotkb/F1MPF7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MPF7", "url": "https://www.uniprot.org/uniprotkb/F1MPF7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PHIP", "url": "https://www.uniprot.org/uniprotkb/F1MPF7", "locus": { "chromosome": "9", "start_pos": 18522256, "end_pos": 18646824, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000024688", "url": "https://www.ensembl.org/id/ENSBTAG00000024688" } ] } } ], "crossref": [ { "id": "ENSBTAG00000024688", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024688", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05496", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05496", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05529", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05529", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "523186", "url": "https://www.ncbi.nlm.nih.gov/gene/523186", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052060", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052060", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057451", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057451", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LLQ0", "url": "https://www.orthodb.org/?gene=A0A3Q1LLQ0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MPF7", "url": "https://www.orthodb.org/?gene=F1MPF7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16266", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16266", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16266:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16266:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00439", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00439", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25313", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25313", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25437", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25437", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9013418", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013418", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LLQ0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LLQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPF7", "url": "https://www.uniprot.org/uniprotkb/F1MPF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPF7-1", "url": "https://www.uniprot.org/uniprotkb/F1MPF7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSRERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKEVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWKGSALAALHCGRPPESPINYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIFGFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSRYQRLVPGRENCREEQLIPQMGVTSSGLNQVLSQQANQDISPLDSMIQRLQQEQDLRRSGEAAISNTSRLSRGSTSSTSEVHSPPNVGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWSRRVVVPELSSGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVPKENKMPTVSKNHAHEHFVDLGESKKQQANQHNYRTRSALEETPRPSEEIENGTSSSDEGEVVAVSGGTSEEEERAWHSDGSSSDYSSDYSDWTADAGINLQPPKKIPKHKTKKAESSSDEEEESEKQKQKQIKKDRKKINEEKDGPVSPKKKKPKERKQKRLAVGELTENGLTLEEWLPSTWITDTLPRRCPFVPQMGDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCCLKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQFEDAKYRRWNIGDRFRSVIDDAWWFGTIESQEPLQPEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPEELGTSVPLTDVETRSLIYKPLDGEWGSNPRDEECERIVTGINQLMTLDIASAFVAPVDLQAYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDLLLHFIKDQTCYNIIPLYNSMKKKVLSDSEEEEKEDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQAWKKQCQELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNTITKRRRKRNRSSSVSSSAASSPERKKRILKPQLKSDITTSPFSAPTRSIPPRHNTAQINGKTESSSVVRTRSNRVVVDPVTTEQPSTSSAAKTFISKANTSAMPGKTVLENSVKHSKTLNTLSSPGQSNFSHGTRNNSTKENMEKEKPAKRKMKSSVLSKTPPLSKSSPVIEQADCRNNALVPGSIQVNGHGGQPSKLVKRGPGRKPKVEVNNSSGEVTHKKRGRKPKKLQYTKPEVSEQNSVHPIRDEVVPSSTCSFLSETNIIKEDLLQKKSRGGRKPKRKMKTQKLDSDLIVPTSVKMLRRSNRKKTDDPMDEEEEFEELKGSEPHMRTRNQGRRTAFYNEDDSEEEQRQLLFEDTSLTFGTSSRGRVRKLTEKAKANLIGW", "length": 1802, "header": "tr|F1MPF7-1|F1MPF7_BOVIN Isoform 1 of PH-interacting protein OS=Bos taurus OX=9913 GN=PHIP PE=4 SV=3 CANONICAL=F1MPF7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LLQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLQ0/entry", "sequence": { "sequence": "MSRERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTYQNLVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWKGSALAALHCGRPPESPINYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIFGFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSRYQRLVPGRENCREEQLIPQMGVTSSGLNQVLSQQANQDISPLDSMIQRLQQEQDLRRSGEAAISNTSRLSRGSTSSTSEVHSPPNVGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWSRRVVVPELSSGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVPKENKMPTVSKNHAHEHFVDLGESKKQQANQHNYRTRSALEETPRPSEEIENGTSSSDEGEVVAVSGGTSEEEERAWHSDGSSSDYSSDYSDWTADAGINLQPPKKIPKHKTKKAESSSDEEEESEKQKQKQIKKDRKKINEEKDGPVSPKKKKPKERKQKRLAVGELTENGLTLEEWLPSTWITDTLPRRCPFVPQMGDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCCLKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQFEDAKYRRWNIGDRFRSVIDDAWWFGTIESQEPLQPEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPEELGTSVPLTDVETRSLIYKPLDGEWGSNPRDEECERIVTGINQLMTLDIASAFVAPVDLQAYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDLLLHFIKDQTCYNIIPLYNSMKKKVLSDSEEEEKEDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQAWKKQCQELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNTITKRRRKRNRSSSVSSSAASSPERKKRILKPQLKSDITTSPFSAPTRSIPPRHNTAQINGKTESSSVVRTRSNRVVVDPVTTEQPSTSSAAKTFISKANTSAMPGKTADCRNNALVPGSIQVNGHGGQPSKLVKRGPGRKPKVEVNNSSGEVTHKKRGRKPKKLQYTKPEVSEQNSVHPIRDEVVPSSTCSFLSETNIIKEDLLQKKSRGGRKPKRKMKTQKLDSDLIVPTSVKMLRRSNRKKTDDPMDEEEEFEELKGSEPHMRTRNQGRRTAFYNEDDSEEEQRQLLFEDTSLTFGTSSRGRVRKLTEKAKANLIGW", "length": 1756, "header": "tr|A0A3Q1LLQ0-1|F1MPF7_BOVIN Computationally mapped isoform of PH-interacting protein OS=Bos taurus OX=9913 GN=PHIP PE=4 SV=2 CANONICAL=F1MPF7-1" }, "locus": { "chromosome": "9", "start_pos": 18646618, "end_pos": 18523260, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081574.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081574.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057709.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057709.2" } ] } }, { "isoform_ac": "F1MPF7-1", "url": "https://www.uniprot.org/uniprotkb/F1MPF7/entry", "sequence": { "sequence": "MSRERKGLSELRSELYFLIARFLEDGPCQQAAQVLIREVAEKEVKYYRHLAPDHLLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWKGSALAALHCGRPPESPINYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWDAGTLKINPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSILLDMATRPAGQNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAVFDCKCSPDGQHFACTDSHGHLLIFGFGSSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQAPHLMPPPFLVDVDGNPHPSRYQRLVPGRENCREEQLIPQMGVTSSGLNQVLSQQANQDISPLDSMIQRLQQEQDLRRSGEAAISNTSRLSRGSTSSTSEVHSPPNVGLRRSGQIEGVRQMHSNAPRSEIATERDLVAWSRRVVVPELSSGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVPKENKMPTVSKNHAHEHFVDLGESKKQQANQHNYRTRSALEETPRPSEEIENGTSSSDEGEVVAVSGGTSEEEERAWHSDGSSSDYSSDYSDWTADAGINLQPPKKIPKHKTKKAESSSDEEEESEKQKQKQIKKDRKKINEEKDGPVSPKKKKPKERKQKRLAVGELTENGLTLEEWLPSTWITDTLPRRCPFVPQMGDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHKMELREQELMKIVGIKYEVGLPTLCCLKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQFEDAKYRRWNIGDRFRSVIDDAWWFGTIESQEPLQPEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPNNAVFPEELGTSVPLTDVETRSLIYKPLDGEWGSNPRDEECERIVTGINQLMTLDIASAFVAPVDLQAYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDLLLHFIKDQTCYNIIPLYNSMKKKVLSDSEEEEKEDADVPGTSTRKRKDHQPRRRLRNRAQSYDIQAWKKQCQELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFATVRETLEAGNYESPMELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRNTITKRRRKRNRSSSVSSSAASSPERKKRILKPQLKSDITTSPFSAPTRSIPPRHNTAQINGKTESSSVVRTRSNRVVVDPVTTEQPSTSSAAKTFISKANTSAMPGKTVLENSVKHSKTLNTLSSPGQSNFSHGTRNNSTKENMEKEKPAKRKMKSSVLSKTPPLSKSSPVIEQADCRNNALVPGSIQVNGHGGQPSKLVKRGPGRKPKVEVNNSSGEVTHKKRGRKPKKLQYTKPEVSEQNSVHPIRDEVVPSSTCSFLSETNIIKEDLLQKKSRGGRKPKRKMKTQKLDSDLIVPTSVKMLRRSNRKKTDDPMDEEEEFEELKGSEPHMRTRNQGRRTAFYNEDDSEEEQRQLLFEDTSLTFGTSSRGRVRKLTEKAKANLIGW", "length": 1802, "header": "tr|F1MPF7-1|F1MPF7_BOVIN Isoform 1 of PH-interacting protein OS=Bos taurus OX=9913 GN=PHIP PE=4 SV=3 CANONICAL=F1MPF7-1" }, "locus": { "chromosome": "9", "start_pos": 18646618, "end_pos": 18523260, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034372.4", "url": "https://www.ensembl.org/id/ENSBTAT00000034372.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034268.4", "url": "https://www.ensembl.org/id/ENSBTAP00000034268.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-9013418", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013418", "resource": "Reactome", "description": "RHOBTB2 GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MPF7", "url": "https://www.uniprot.org/uniprotkb/F1MPF7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "F1MPF7", "url": "https://www.uniprot.org/uniprotkb/F1MPF7" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "F1MPF7", "url": "https://www.uniprot.org/uniprotkb/F1MPF7" } ], "pmid": "" }, { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "F1MPF7", "url": "https://www.uniprot.org/uniprotkb/F1MPF7" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MPF7", "url": "https://www.uniprot.org/uniprotkb/F1MPF7" } ], "pmid": "" }, { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "F1MPF7", "url": "https://www.uniprot.org/uniprotkb/F1MPF7" } ], "pmid": "" }, { "name": "regulation of cell shape", "id": "GO:0008360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008360", "evidence": [ { "database": "UniProtKB", "id": "F1MPF7", "url": "https://www.uniprot.org/uniprotkb/F1MPF7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "histone reader activity", "id": "GO:0140566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140566", "evidence": [ { "database": "UniProtKB", "id": "F1MPF7", "url": "https://www.uniprot.org/uniprotkb/F1MPF7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1426, "end_pos": 1428, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1516, "end_pos": 1518, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1546, "end_pos": 1548, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1553, "end_pos": 1555, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1554, "end_pos": 1556, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1629, "end_pos": 1631, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1630, "end_pos": 1632, "annotation": "n_glycosylation_sequon" }, { "start_pos": 355, "end_pos": 357, "annotation": "n_glycosylation_sequon" }, { "start_pos": 425, "end_pos": 427, "annotation": "n_glycosylation_sequon" }, { "start_pos": 646, "end_pos": 648, "annotation": "n_glycosylation_sequon" }, { "start_pos": 794, "end_pos": 796, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MPF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF7" }, { "id": "PS50014", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50014" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Bromo", "eco_id": "ECO_0000259", "start_pos": 1156, "end_pos": 1226, "start_aa": "Met", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1426, "end_pos": 1428 }, { "start_pos": 1516, "end_pos": 1518 }, { "start_pos": 1546, "end_pos": 1548 }, { "start_pos": 1553, "end_pos": 1555 }, { "start_pos": 1554, "end_pos": 1556 }, { "start_pos": 1629, "end_pos": 1631 }, { "start_pos": 1630, "end_pos": 1632 }, { "start_pos": 355, "end_pos": 357 }, { "start_pos": 425, "end_pos": 427 }, { "start_pos": 646, "end_pos": 648 }, { "start_pos": 794, "end_pos": 796 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MRW6-1", "uniprot_ac": "F1MRW6", "uniprot_id": "F1MRW6_BOVIN", "mass": { "chemical_mass": 113330.0, "monoisotopic_mass": 113330.0 }, "refseq": {}, "gene_names": [ { "name": "PLEKHM2", "type": "recommended", "evidence": [ { "id": "F1MRW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW6" } ] } ], "protein_names": [ { "name": "Pleckstrin homology domain-containing family M member 2", "type": "recommended", "evidence": [ { "id": "F1MRW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.", "evidence": [ { "database": "UniProtKB", "id": "F1MRW6", "url": "https://www.uniprot.org/uniprotkb/F1MRW6#function" }, { "database": "UniProtKB", "id": "ARBA00056822", "url": "https://www.uniprot.org/uniprotkb/ARBA00056822#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MRW6", "url": "https://www.uniprot.org/uniprotkb/F1MRW6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PLEKHM2", "url": "https://www.uniprot.org/uniprotkb/F1MRW6", "locus": { "chromosome": "16", "start_pos": 51825824, "end_pos": 51865715, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018722", "url": "https://www.ensembl.org/id/ENSBTAG00000018722" } ] } } ], "crossref": [ { "id": "F1MRW6", "url": "https://alphafold.ebi.ac.uk/entry/F1MRW6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018722", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018722", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13309", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13309", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17680", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17680", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515552", "url": "https://www.ncbi.nlm.nih.gov/gene/515552", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004012", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004012", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053015", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053015", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057288", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057288", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MRW6", "url": "https://www.orthodb.org/?gene=F1MRW6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46556", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46556", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46556:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46556:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02759", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02759", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23142", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23142", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LMH7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LMH7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMH7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLR3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLR3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MLR3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLR3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRW6", "url": "https://www.uniprot.org/uniprotkb/F1MRW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRW6-1", "url": "https://www.uniprot.org/uniprotkb/F1MRW6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPREVKDRILENISLSVKKLQSYFAACEDETPAIRNHDKVLQRLCEHLDHALLYGLQDLSSGYWVLVVHFTRREAVKHIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFDLDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTTLEWDDSAIAPSSEDGDLTDTVSGPRSTTSDPTSSKASTKSPTQRHNPFNEDQAETVSSSDTTPVHTSSQEKGESHTPDLPDTCTELEVIRVTKKKKTGKKKKPRSDEEASPLHPASTQHTCARQGNGDPVVSSPGPGQGSPDTTLASPPQEGQGPGSTVEGSERSEPGQVGLLIPEMKDTSMERVGQPLSKVIDQLNGQLDPATWRSHVEPPDQSFRTGSPGDAPERPPFCDFSEGLPAPMDFYRFTVESPSAVTSGGGHHDPAGPGQPLHVPGSPAAAGQEEAGGGGGPGQTPRPLEDTPGEAQKPEAQELDAQLPQDGEGLEPEPGTQEALCRLKGDQPSPCLSSAEDSGVEEGQGSPSEMTHSAEFRVDNNHLLLLMIHVFRENEEQLFRMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDYVSPALCLAMAAPVAAAAKLRVHVGCGFRQVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEATAVTVRFYGLVHWEDPQDEFLGPTPCHCSPPEGTITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVTPLLSVNMGGEQCGGCRRSNTTDRPHAFQVILADRPCLELSADSEAEMADWMQHLCQAVSKGVIPQGVAPSPCIPCCLVITDDRLFTCHEDCQTSFFRSLGTAKLADISAVSTEPGKEYCLLEFSQDSAQPLPPWVVYLSCTPELDRFLSALNSGWKTIYQVDLPHKAIQEASKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC", "length": 1032, "header": "tr|F1MRW6-1|F1MRW6_BOVIN Isoform 1 of Pleckstrin homology domain-containing family M member 2 OS=Bos taurus OX=9913 GN=PLEKHM2 PE=4 SV=4 CANONICAL=F1MRW6-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LMH7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LMH7/entry", "sequence": { "sequence": "MRPLPSATTTKSCSVYVSTWTTLCSTGRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFDLDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTTLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTVSGPRSTTSDPTSSKASTKSPTQRHNPFNEDQAETVSSSDTTPVHTSSQEKGESHTPDLPDTCTELEVIRVTKKKKTGKKKKPRSDEEASPLHPASTQHTCARQGNGDPVVSSPGPGQGSPDTTLASPPQEGQGPGSTVEGSERSEPGQVGLLIPEMKDTSMERVGQPLSKVIDQLNGQLDPATWRSHVEPPDQSFRTGSPGDAPERPPFCDFSEGLPAPMDFYRFTVESPSAVTSGGGHHDPAGPGQPLHVPGSPAAAGQEEAGGGGGPGQTPRPLEDTPGEAQKPEAQELDAQLPQDGEGLEPEPGTQEALCRLKGDQPSPCLSSAEDSGVEEGQGSPSEMTHSAEFRVDNNHLLLLMIHVFRENEEQLFRMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEATAVTVRFYGLVHWEDPQDEFLGPTPCHCSPPEGTITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVTPLLSVNMGGEQCGGCRRSNTTDRPHAFQVILADRPCLELSADSEAEMADWMQHLCQAVSKGVIPQGVAPSPCIPCCLVITDDRLFTCHEDCQTSFFRSLGTAKLADISAVSTEPGKEYCLLEFSQDSAQPLPPWVVYLSCTPELDRFLSALNSGWKTIYQVDLPHKAIQEASKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC", "length": 959, "header": "tr|A0A3Q1LMH7-1|F1MRW6_BOVIN Computationally mapped isoform of Pleckstrin homology domain-containing family M member 2 OS=Bos taurus OX=9913 GN=PLEKHM2 PE=4 SV=1 CANONICAL=F1MRW6-1" }, "locus": { "chromosome": "16", "start_pos": 51841227, "end_pos": 51826653, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000066799.2", "url": "https://www.ensembl.org/id/ENSBTAT00000066799.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057895.1", "url": "https://www.ensembl.org/id/ENSBTAP00000057895.1" } ] } }, { "isoform_ac": "A0A3Q1MLR3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLR3/entry", "sequence": { "sequence": "MALPQERRLLGCLLSSATPPPSAPCQAKESWHLLDLPPTYSCPSFAGRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFDLDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTTLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGDLTDTVSGPRSTTSDPTSSKASTKSPTQRHNPFNEDQAETVSSSDTTPVHTSSQEKGESHTPDLPDTCTELEVIRVTKKKKTGKKKKPRSDEEASPLHPASTQHTCARQGNGDPVVSSPGPGQGSPDTTLASPPQEGQGPGSTVEGSERSEPGQVGLLIPEMKDTSMERVGQPLSKVIDQLNGQLDPATWRSHVEPPDQSFRTGSPGDAPERPPFCDFSEGLPAPMDFYRFTVESPSAVTSGGGHHDPAGPGQPLHVPGSPAAAGQEEAGGGGGPGQTPRPLEDTPGEAQKPEAQELDAQLPQDGEGLEPEPGTQEALCRLKGDQPSPCLSSAEDSGVEEGQGSPSEMTHSAEFRVDNNHLLLLMIHVFRENEEQLFRMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEATAVTVRFYGLVHWEDPQDEFLGPTPCHCSPPEGTITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVTPLLSVNMGGEQCGGCRRSNTTDRPHAFQVILADRPCLELSADSEAEMADWMQHLCQAVSKGVIPQGVAPSPCIPCCLVITDDRLFTCHEDCQTSFFRSLGTAKLADISAVSTEPGKEYCLLEFSQDSAQPLPPWVVYLSCTPELDRFLSALNSGWKTIYQVDLPHKAIQEASKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC", "length": 979, "header": "tr|A0A3Q1MLR3-1|F1MRW6_BOVIN Computationally mapped isoform of Pleckstrin homology domain-containing family M member 2 OS=Bos taurus OX=9913 GN=PLEKHM2 PE=4 SV=2 CANONICAL=F1MRW6-1" }, "locus": { "chromosome": "16", "start_pos": 51840202, "end_pos": 51826653, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079024.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079024.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070275.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070275.2" } ] } }, { "isoform_ac": "F1MRW6-1", "url": "https://www.uniprot.org/uniprotkb/F1MRW6/entry", "sequence": { "sequence": "MEPREVKDRILENISLSVKKLQSYFAACEDETPAIRNHDKVLQRLCEHLDHALLYGLQDLSSGYWVLVVHFTRREAVKHIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFDLDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTTLEWDDSAIAPSSEDGDLTDTVSGPRSTTSDPTSSKASTKSPTQRHNPFNEDQAETVSSSDTTPVHTSSQEKGESHTPDLPDTCTELEVIRVTKKKKTGKKKKPRSDEEASPLHPASTQHTCARQGNGDPVVSSPGPGQGSPDTTLASPPQEGQGPGSTVEGSERSEPGQVGLLIPEMKDTSMERVGQPLSKVIDQLNGQLDPATWRSHVEPPDQSFRTGSPGDAPERPPFCDFSEGLPAPMDFYRFTVESPSAVTSGGGHHDPAGPGQPLHVPGSPAAAGQEEAGGGGGPGQTPRPLEDTPGEAQKPEAQELDAQLPQDGEGLEPEPGTQEALCRLKGDQPSPCLSSAEDSGVEEGQGSPSEMTHSAEFRVDNNHLLLLMIHVFRENEEQLFRMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDYVSPALCLAMAAPVAAAAKLRVHVGCGFRQVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEATAVTVRFYGLVHWEDPQDEFLGPTPCHCSPPEGTITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVTPLLSVNMGGEQCGGCRRSNTTDRPHAFQVILADRPCLELSADSEAEMADWMQHLCQAVSKGVIPQGVAPSPCIPCCLVITDDRLFTCHEDCQTSFFRSLGTAKLADISAVSTEPGKEYCLLEFSQDSAQPLPPWVVYLSCTPELDRFLSALNSGWKTIYQVDLPHKAIQEASKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC", "length": 1032, "header": "tr|F1MRW6-1|F1MRW6_BOVIN Isoform 1 of Pleckstrin homology domain-containing family M member 2 OS=Bos taurus OX=9913 GN=PLEKHM2 PE=4 SV=4 CANONICAL=F1MRW6-1" }, "locus": { "chromosome": "16", "start_pos": 51865604, "end_pos": 51826653, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024919.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024919.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024919.7", "url": "https://www.ensembl.org/id/ENSBTAP00000024919.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 755, "start_aa": "Thr", "end_pos": 755, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr755", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 775, "start_aa": "Thr", "end_pos": 775, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr775", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "F1MRW6", "url": "https://www.uniprot.org/uniprotkb/F1MRW6" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "F1MRW6", "url": "https://www.uniprot.org/uniprotkb/F1MRW6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of protein localization", "id": "GO:0032880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032880", "evidence": [ { "database": "UniProtKB", "id": "F1MRW6", "url": "https://www.uniprot.org/uniprotkb/F1MRW6" } ], "pmid": "" }, { "name": "Golgi organization", "id": "GO:0007030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", "evidence": [ { "database": "UniProtKB", "id": "F1MRW6", "url": "https://www.uniprot.org/uniprotkb/F1MRW6" } ], "pmid": "" }, { "name": "lysosome localization", "id": "GO:0032418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032418", "evidence": [ { "database": "UniProtKB", "id": "F1MRW6", "url": "https://www.uniprot.org/uniprotkb/F1MRW6" } ], "pmid": "" }, { "name": "natural killer cell mediated cytotoxicity", "id": "GO:0042267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042267", "evidence": [ { "database": "UniProtKB", "id": "F1MRW6", "url": "https://www.uniprot.org/uniprotkb/F1MRW6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "kinesin binding", "id": "GO:0019894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019894", "evidence": [ { "database": "UniProtKB", "id": "F1MRW6", "url": "https://www.uniprot.org/uniprotkb/F1MRW6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 13, "end_pos": 15, "annotation": "n_glycosylation_sequon" }, { "start_pos": 847, "end_pos": 849, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], 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}, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", 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It plays a critical role in buffering intracellular calcium levels and modulating calcium-dependent signaling pathways. Predominantly expressed in specific neuronal populations, influences synaptic plasticity and neuronal excitability, contributing to learning and memory. 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"Ensembl Gene", "id": "ENSBTAG00000001075", "url": "https://www.ensembl.org/id/ENSBTAG00000001075" } ] } } ], "crossref": [ { "id": "F1MJW8", "url": "https://alphafold.ebi.ac.uk/entry/F1MJW8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001075", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001075", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16177", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16177", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513947", "url": "https://www.ncbi.nlm.nih.gov/gene/513947", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029646", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029646", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IVLCNEP", "url": "https://omabrowser.org/oma/group/IVLCNEP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LNC3", "url": "https://www.orthodb.org/?gene=A0A3Q1LNC3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MJW8", "url": "https://www.orthodb.org/?gene=F1MJW8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19972", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19972", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19972:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19972:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00036", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00036", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LNC3", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LNC3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNC3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGL7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGL7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSV2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZ60", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NZ60-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ60-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJW8", "url": "https://www.uniprot.org/uniprotkb/F1MJW8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJW8-1", "url": "https://www.uniprot.org/uniprotkb/F1MJW8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGPQQQPPYLHLAELTATQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMVSKSDNLGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSTEFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLLPVQENFLLKFQGMKLTSEEFNAIFTFYDKDGSGYIDENELDALLKDLYEKNKKEMNIQQLTSYRKSVMSLAEAGKLYRKDLEIVLCSEPPL", "length": 271, "header": "tr|F1MJW8-1|F1MJW8_BOVIN Isoform 1 of Calretinin OS=Bos taurus OX=9913 GN=CALB2 PE=3 SV=1 CANONICAL=F1MJW8-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LNC3-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNC3/entry", "sequence": { "sequence": "MAGPQQQPPYLHLAELTATQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMVSKSDNLGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSTEFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRTEVATLMRMNWTPS", "length": 192, "header": "tr|A0A3Q1LNC3-1|F1MJW8_BOVIN Computationally mapped isoform of Calretinin OS=Bos taurus OX=9913 GN=CALB2 PE=3 SV=2 CANONICAL=F1MJW8-1" }, "locus": { "chromosome": "18", "start_pos": 39702336, "end_pos": 39677572, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000079318.2", "url": "https://www.ensembl.org/id/ENSBTAT00000079318.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058300.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058300.2" } ] } }, { "isoform_ac": "A0AAA9SGL7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGL7/entry", "sequence": { "sequence": "MAGPQQQPPYLHLAELTATQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMVSKSDNLGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSTEFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDVPDLTHPSITGMKLTSEEFNAIFTFYDKDGSGYIDENELDALLKDLYEKNKKEMNIQQLTSYRKSVMSLAEAGKLYRKDLEIVLCSEPPL", "length": 258, "header": "tr|A0AAA9SGL7-1|F1MJW8_BOVIN Computationally mapped isoform of Calretinin OS=Bos taurus OX=9913 GN=CALB2 PE=3 SV=1 CANONICAL=F1MJW8-1" }, "locus": { "chromosome": "18", "start_pos": 39702336, "end_pos": 39673681, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124551.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124551.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082838.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082838.1" } ] } }, { "isoform_ac": "A0AAA9SSV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSV2/entry", "sequence": { "sequence": "MAGPQQQPPYLHLAELTATQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMVSKSDNLGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSTEFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLLPVQENFLLKFQGMKLTSEEFNAIFTFYDKEMNIQQLTSYRKSVMSLAEAGKLYRKDLEIVLCSEPPL", "length": 247, "header": "tr|A0AAA9SSV2-1|F1MJW8_BOVIN Computationally mapped isoform of Calretinin OS=Bos taurus OX=9913 GN=CALB2 PE=3 SV=1 CANONICAL=F1MJW8-1" }, "locus": { "chromosome": "18", "start_pos": 39702336, "end_pos": 39673681, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106343.1", "url": "https://www.ensembl.org/id/ENSBTAT00000106343.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087198.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087198.1" } ] } }, { "isoform_ac": "A0ABI0NZ60-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NZ60/entry", "sequence": { "sequence": "MAGPQQQPPYLHLAELTATQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMVSKSDNLGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSTEFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLLPVQENFLLKFQDGSGYIDENELDALLKDLYEKNKKEMNIQQLTSYRKSVMSLAEAGKLYRKDLEIVLCSEPPL", "length": 253, "header": "tr|A0ABI0NZ60-1|A0ABI0NZ60_BOVIN Computationally mapped isoform of Calbindin 2 OS=Bos taurus OX=9913 GN=CALB2 PE=3 SV=1 CANONICAL=F1MJW8-1" }, "locus": { "chromosome": "18", "start_pos": 39702336, "end_pos": 39673681, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151756.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151756.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106875.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106875.1" } ] } }, { "isoform_ac": "F1MJW8-1", "url": "https://www.uniprot.org/uniprotkb/F1MJW8/entry", "sequence": { "sequence": "MAGPQQQPPYLHLAELTATQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMVSKSDNLGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSTEFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLLPVQENFLLKFQGMKLTSEEFNAIFTFYDKDGSGYIDENELDALLKDLYEKNKKEMNIQQLTSYRKSVMSLAEAGKLYRKDLEIVLCSEPPL", "length": 271, "header": "tr|F1MJW8-1|F1MJW8_BOVIN Isoform 1 of Calretinin OS=Bos taurus OX=9913 GN=CALB2 PE=3 SV=1 CANONICAL=F1MJW8-1" }, "locus": { "chromosome": "18", "start_pos": 39702336, "end_pos": 39673681, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001426.4", "url": "https://www.ensembl.org/id/ENSBTAT00000001426.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001426.2", "url": "https://www.ensembl.org/id/ENSBTAP00000001426.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "G3HAG0-1", "protein_name": "Calretinin", "gene_name": "Calb2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMPKSDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSAEFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLLPVQENFLLKFQGMKLTSEEFNAIFTFYDKDGSGYIDENELDALLKDLYEKNKKEMNIQQLTTYRKSVMSLAEAGKLYRKDLEIVLCSEPPM", "length": 271 }, "evidence": [ { "id": "F1MJW8", "url": "https://omabrowser.org/oma/group/F1MJW8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P07090-1", "protein_name": "Calretinin", "gene_name": "CALB2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGQRAPHLHLAELSASQFLDVWRHFDADGNGYIEGKELENFFQELESARKGTGVDSKRDSLGDKMKEFMHKYDKNADGKIEMAELAQILPTEENFLLCFRQHVGSSSEFMEAWRRYDTDRSGYIEANELKGFLSDLLKKANRPYDEAKLQEYTQTILRMFDMNGDGKLGLSEMSRLLPVQENFLLKFQGMKLSSEEFNAIFAFYDKDGSGFIDEHELDALLKDLYEKNKKEMSIQQLTNYRRSIMNLSDGGKLYRKELEVVLCSEPPL", "length": 269 }, "evidence": [ { "id": "F1MJW8", "url": "https://omabrowser.org/oma/group/F1MJW8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P22676-1", "protein_name": "Calretinin", "gene_name": "CALB2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSKSDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSAEFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLLPVQENFLLKFQGMKLTSEEFNAIFTFYDKDRSGYIDEHELDALLKDLYEKNKKEMNIQQLTNYRKSVMSLAEAGKLYRKDLEIVLCSEPPM", "length": 271 }, "evidence": [ { "id": "F1MJW8", "url": "https://omabrowser.org/oma/group/F1MJW8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P41044-1", "protein_name": "Calbindin-32", "gene_name": "Cbp53E", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDSAAAAAAKRVQIEKAHNFMRQYRDPESRELKKLSANQFMDVWAHYDKDGNGYIEGTELDGFLREFVSSANATDISPEAVTDTMLEELKSCFMEAYDDNQDGKIDIRELAQLLPMEENFLLLFRFDNPLESSVEFMKIWREYDTDNSGYIEADELKNFLRDLLKEAKKINDVSEDKLIEYTDTMLQVFDANKDGRLQLSEMAKLLPVKENFLCRQVFKGATKLTKEDIEKVFSLYDRDNSGTIENEELKGFLKDLLELVKKDDYDAQDLAAFEETIMRGVGTDKHGKISRKELTMILLTLAKISPDDEE", "length": 310 }, "evidence": [ { "id": "F1MJW8", "url": "https://omabrowser.org/oma/group/F1MJW8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P47728-1", "protein_name": "Calretinin", "gene_name": "Calb2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSKSDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSAEFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLLPVQENFLLKFQGMKLTSEEFNAIFTFYDKDGSGYIDENELDALLKDLYEKNKKEMNIQQLTTYRKSVMSLAEAGKLYRKDLEIVLCSEPPM", "length": 271 }, "evidence": [ { "id": "F1MJW8", "url": "https://omabrowser.org/oma/group/F1MJW8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q08331-1", "protein_name": "Calretinin", "gene_name": "Calb2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSKSDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCFRQHVGSSAEFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMSRLLPVQENFLLKFQGMKLTSEEFNAIFTFYDKDGSGYIDENELDALLKDLYEKNKKEMNIQQLTTYRKSVMSLAEAGKLYRKDLEIVLCSEPPV", "length": 271 }, "evidence": [ { "id": "F1MJW8", "url": "https://omabrowser.org/oma/group/F1MJW8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MJW8", "url": "https://www.uniprot.org/uniprotkb/F1MJW8" } ], "pmid": "" }, { "name": "calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration", "id": "GO:0099534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099534", "evidence": [ { "database": "UniProtKB", "id": "F1MJW8", "url": "https://www.uniprot.org/uniprotkb/F1MJW8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "F1MJW8", "url": "https://www.uniprot.org/uniprotkb/F1MJW8" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1MJW8", "url": "https://www.uniprot.org/uniprotkb/F1MJW8" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MJW8", "url": "https://www.uniprot.org/uniprotkb/F1MJW8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MJW8", "url": "https://www.uniprot.org/uniprotkb/F1MJW8" } ], "pmid": "" }, { "name": "terminal bouton", "id": "GO:0043195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043195", "evidence": [ { "database": "UniProtKB", "id": "F1MJW8", "url": "https://www.uniprot.org/uniprotkb/F1MJW8" } ], "pmid": "" }, { "name": "gap junction", "id": "GO:0005921", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005921", "evidence": [ { "database": "UniProtKB", "id": "F1MJW8", "url": "https://www.uniprot.org/uniprotkb/F1MJW8" } ], "pmid": "" }, { "name": "parallel fiber to Purkinje cell synapse", "id": "GO:0098688", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098688", "evidence": [ { "database": "UniProtKB", "id": "F1MJW8", "url": "https://www.uniprot.org/uniprotkb/F1MJW8" } ], "pmid": "" }, { "name": "dendriole", "id": "GO:0044293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044293", "evidence": [ { "database": "UniProtKB", "id": "F1MJW8", "url": "https://www.uniprot.org/uniprotkb/F1MJW8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of synaptic plasticity", "id": "GO:0048167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048167", "evidence": [ { "database": "UniProtKB", "id": "F1MJW8", "url": "https://www.uniprot.org/uniprotkb/F1MJW8" } ], "pmid": "" }, { "name": "synaptic signaling", "id": "GO:0099536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099536", "evidence": [ { "database": "UniProtKB", "id": "F1MJW8", "url": "https://www.uniprot.org/uniprotkb/F1MJW8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJW8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 271, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJW8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJW8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJW8" }, { "id": "PS50222", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50222" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EF-hand", "eco_id": "ECO_0000259", "start_pos": 16, "end_pos": 51, "start_aa": "Leu", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MLE1-1", "uniprot_ac": "F1MLE1", "uniprot_id": "F1MLE1_BOVIN", "mass": { "chemical_mass": 179875.0, "monoisotopic_mass": 179875.0 }, "refseq": {}, "gene_names": [ { "name": "DIP2B", "type": "recommended", "evidence": [ { "id": "F1MLE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLE1" } ] } ], "protein_names": [ { "name": "Disco interacting B", "type": "synonym", "evidence": [ { "id": "F1MLE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLE1/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MLE1", "url": "https://www.uniprot.org/uniprotkb/F1MLE1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DIP2B", "url": "https://www.uniprot.org/uniprotkb/F1MLE1", "locus": { "chromosome": "5", "start_pos": 29182879, "end_pos": 29412743, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005246", "url": "https://www.ensembl.org/id/ENSBTAG00000005246" } ] } } ], "crossref": [ { "id": "ENSBTAG00000005246", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005246", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05905", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05905", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010506", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010506", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037337", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037337", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LPC0", "url": "https://www.orthodb.org/?gene=A0A3Q1LPC0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MLE1", "url": "https://www.orthodb.org/?gene=F1MLE1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22754", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22754", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22754:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22754:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00501", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06464", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06464", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23024", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23024", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LPC0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPC0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LPC0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPC0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLE1", "url": "https://www.uniprot.org/uniprotkb/F1MLE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLE1-1", "url": "https://www.uniprot.org/uniprotkb/F1MLE1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSPGVRSLTRLRRRCVLSPGAGPPGSHDPCSWRRRQRLRWRRSAAGAGSCSRGVGPRQSVPPSAPSFVFRSVAGRAGMAERGLEPSPAAVAALPPEVRAQLAELELELSEGDITQKGYEKKRSKLLSPYIPQTQETDSSVQKEHRNQTPAPSAATTSAPSKYHRSRSGGARDERYRSDIHTEAVQAALAKHKEQKMALPMPTKRRSTFVQSPADACTPPDTSSASEDEGSLRRQAALSAALQQSLQNAESWINRSIQGSSTSSSASSTLSHGEVKGTSGSLADVFANTRIENFSAPPDVTTTTSSSSSSSIRPANIDLPPSGIVKGMHKGSNRSSLMDTADGVPVNSRVSTKIQQLLNTLKRPKRPPLKEFFVDDSEEIVEGSVPQPDPNQPKPEGRQMTPVKGEPLGVICNWPPALESALQRWGTTQAKCPCLTALDVTGKPVYTLTYGKLWSRSLKLAYTLLNKLGTKNEPVLKPGDRVALVYPNNDPVMFMVAFYGCLLAEVIPVPIEVPLTRKDAGGQQIGFLLGSCGIALALTSEVCLKGLPKTQNGEIVQFKGWPRLKWVVTDSKYLSKPPKDWQPLISPASTEPAYIEYKTSKEGSVMGVTVSRLAMLSHCQALSQACNYSEGETVVNVLDFKKDAGLWHGMFANVMNKMHTISVPYSVMKTCPLSWVQRVHAHKAKVALVKCRDLHWAMMAHRDQRDVSLSSLRMLIVTDGANPWSVSSCDAFLSLFQSHGLKPEAICPCATSAEAMTVAIRRPGVPGAPLPGRAILSMNGLSYGVIRVNTEDKNSALTVQDVGHVMPGGMMCIVKPDGPPQLCKTDEIGEICVSSRTGGMMYFGLAGVTKNTFEVIPVNSAGSPVGDVPFIRSGLLGFVGPGSLVFVVGKMDGLLMVSGRRHNADDIVATGLAVESIKTVYRGRIAVFSVSVFYDERIVVVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHISQTKQLFLEGSLHPCNILMCPHTCVTNLPKPRQKQPGVGPASVMVGNLVAGKRIAQAAGRDLGQIEENDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTASCLQLHKRAERIAAVLGDKGHLNAGENVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTATLPTVRMIVDVSKAACILTTQTLMRLLRSREAAAAVDVKTWPTIIDTDDLPRKRLPQLYKPPTPEMLAYLDFSVSTTGMLTGVKMSHSAVNALCRAIKLQCELYSSRQIAICLDPYCGLGFALWCLCSVYSGHQSILIPPMELENNLFLWLSTVNQYKIRDTFCSYSVMELCTKGLGNQVEVLKTRGINLSCIRTCVVVAEERPRIALQQSFSKLFKDIGLSPRAVSTTFGSRVNVAICLQGTSGPDPTTVYVDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIVNPETKGPVGDSHLGEIWVNSPHTASGYYTIYDSETLQADHFNTRLSFGDAAQTLWARTGYLGFVRRTELTAATGERHDALYVVGALDETLELRGLRYHPIDIETSVSRIHRSIAECAVFTWTNLLVVVVELCGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDPGVIPINSRGEKQRMHLRDSFLADQLDPIYVAYNM", "length": 1654, "header": "tr|F1MLE1-1|F1MLE1_BOVIN Isoform 1 of Disco interacting B OS=Bos taurus OX=9913 GN=DIP2B PE=1 SV=3 CANONICAL=F1MLE1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LPC0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LPC0/entry", "sequence": { "sequence": 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"length": 1581, "header": "tr|A0A3Q1LPC0-1|F1MLE1_BOVIN Computationally mapped isoform of Disco interacting B OS=Bos taurus OX=9913 GN=DIP2B PE=1 SV=2 CANONICAL=F1MLE1-1" }, "locus": { "chromosome": "5", "start_pos": 29412544, "end_pos": 29186651, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069544.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069544.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000058856.2", "url": "https://www.ensembl.org/id/ENSBTAP00000058856.2" } ] } }, { "isoform_ac": "F1MLE1-1", "url": "https://www.uniprot.org/uniprotkb/F1MLE1/entry", "sequence": { "sequence": "MSPGVRSLTRLRRRCVLSPGAGPPGSHDPCSWRRRQRLRWRRSAAGAGSCSRGVGPRQSVPPSAPSFVFRSVAGRAGMAERGLEPSPAAVAALPPEVRAQLAELELELSEGDITQKGYEKKRSKLLSPYIPQTQETDSSVQKEHRNQTPAPSAATTSAPSKYHRSRSGGARDERYRSDIHTEAVQAALAKHKEQKMALPMPTKRRSTFVQSPADACTPPDTSSASEDEGSLRRQAALSAALQQSLQNAESWINRSIQGSSTSSSASSTLSHGEVKGTSGSLADVFANTRIENFSAPPDVTTTTSSSSSSSIRPANIDLPPSGIVKGMHKGSNRSSLMDTADGVPVNSRVSTKIQQLLNTLKRPKRPPLKEFFVDDSEEIVEGSVPQPDPNQPKPEGRQMTPVKGEPLGVICNWPPALESALQRWGTTQAKCPCLTALDVTGKPVYTLTYGKLWSRSLKLAYTLLNKLGTKNEPVLKPGDRVALVYPNNDPVMFMVAFYGCLLAEVIPVPIEVPLTRKDAGGQQIGFLLGSCGIALALTSEVCLKGLPKTQNGEIVQFKGWPRLKWVVTDSKYLSKPPKDWQPLISPASTEPAYIEYKTSKEGSVMGVTVSRLAMLSHCQALSQACNYSEGETVVNVLDFKKDAGLWHGMFANVMNKMHTISVPYSVMKTCPLSWVQRVHAHKAKVALVKCRDLHWAMMAHRDQRDVSLSSLRMLIVTDGANPWSVSSCDAFLSLFQSHGLKPEAICPCATSAEAMTVAIRRPGVPGAPLPGRAILSMNGLSYGVIRVNTEDKNSALTVQDVGHVMPGGMMCIVKPDGPPQLCKTDEIGEICVSSRTGGMMYFGLAGVTKNTFEVIPVNSAGSPVGDVPFIRSGLLGFVGPGSLVFVVGKMDGLLMVSGRRHNADDIVATGLAVESIKTVYRGRIAVFSVSVFYDERIVVVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHISQTKQLFLEGSLHPCNILMCPHTCVTNLPKPRQKQPGVGPASVMVGNLVAGKRIAQAAGRDLGQIEENDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTASCLQLHKRAERIAAVLGDKGHLNAGENVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTATLPTVRMIVDVSKAACILTTQTLMRLLRSREAAAAVDVKTWPTIIDTDDLPRKRLPQLYKPPTPEMLAYLDFSVSTTGMLTGVKMSHSAVNALCRAIKLQCELYSSRQIAICLDPYCGLGFALWCLCSVYSGHQSILIPPMELENNLFLWLSTVNQYKIRDTFCSYSVMELCTKGLGNQVEVLKTRGINLSCIRTCVVVAEERPRIALQQSFSKLFKDIGLSPRAVSTTFGSRVNVAICLQGTSGPDPTTVYVDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIVNPETKGPVGDSHLGEIWVNSPHTASGYYTIYDSETLQADHFNTRLSFGDAAQTLWARTGYLGFVRRTELTAATGERHDALYVVGALDETLELRGLRYHPIDIETSVSRIHRSIAECAVFTWTNLLVVVVELCGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDPGVIPINSRGEKQRMHLRDSFLADQLDPIYVAYNM", "length": 1654, "header": "tr|F1MLE1-1|F1MLE1_BOVIN Isoform 1 of Disco interacting B OS=Bos taurus OX=9913 GN=DIP2B PE=1 SV=3 CANONICAL=F1MLE1-1" }, "locus": { "chromosome": "5", "start_pos": 29412544, "end_pos": 29186651, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006902.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006902.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006902.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006902.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "F1MLE1", "url": "https://www.uniprot.org/uniprotkb/F1MLE1" } ], "pmid": "" }, { "name": "negative regulation of axon extension", "id": "GO:0030517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030517", "evidence": [ { "database": "UniProtKB", "id": "F1MLE1", "url": "https://www.uniprot.org/uniprotkb/F1MLE1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "F1MLE1", "url": "https://www.uniprot.org/uniprotkb/F1MLE1" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MLE1", "url": "https://www.uniprot.org/uniprotkb/F1MLE1" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MLE1", "url": "https://www.uniprot.org/uniprotkb/F1MLE1" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "F1MLE1", "url": "https://www.uniprot.org/uniprotkb/F1MLE1" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "F1MLE1", "url": "https://www.uniprot.org/uniprotkb/F1MLE1" } ], "pmid": "" }, { "name": "perikaryon", "id": "GO:0043204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043204", "evidence": [ { "database": "UniProtKB", "id": "F1MLE1", "url": "https://www.uniprot.org/uniprotkb/F1MLE1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "alpha-tubulin binding", "id": "GO:0043014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043014", "evidence": [ { "database": "UniProtKB", "id": "F1MLE1", "url": "https://www.uniprot.org/uniprotkb/F1MLE1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1161, "end_pos": 1163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1353, "end_pos": 1355, "annotation": "n_glycosylation_sequon" }, { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 253, "end_pos": 255, "annotation": "n_glycosylation_sequon" }, { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 332, "end_pos": 334, "annotation": "n_glycosylation_sequon" }, { "start_pos": 626, "end_pos": 628, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MLE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLE1" }, { "id": "PS51912", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51912" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DMAP1-binding", "eco_id": "ECO_0000259", "start_pos": 89, "end_pos": 208, "start_aa": "Ala", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1161, "end_pos": 1163 }, { "start_pos": 1353, "end_pos": 1355 }, { "start_pos": 146, "end_pos": 148 }, { "start_pos": 253, "end_pos": 255 }, { "start_pos": 292, "end_pos": 294 }, { "start_pos": 332, "end_pos": 334 }, { "start_pos": 626, "end_pos": 628 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MTH4-1", "uniprot_ac": "F1MTH4", "uniprot_id": "F1MTH4_BOVIN", "mass": { "chemical_mass": 47810.0, "monoisotopic_mass": 47810.0 }, "refseq": {}, "gene_names": [ { "name": "POLR3D", "type": "recommended", "evidence": [ { "id": "F1MTH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTH4" } ] } ], "protein_names": [ { "name": "RNA polymerase III subunit D", "type": "synonym", "evidence": [ { "id": "F1MTH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTH4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MTH4", "url": "https://www.uniprot.org/uniprotkb/F1MTH4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POLR3D", "url": "https://www.uniprot.org/uniprotkb/F1MTH4", "locus": { "chromosome": "8", "start_pos": 69571387, "end_pos": 69558015, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010036", "url": "https://www.ensembl.org/id/ENSBTAG00000010036" } ] } } ], "crossref": [ { "id": "F1MTH4", "url": "https://alphafold.ebi.ac.uk/entry/F1MTH4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010036", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010036", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR007811", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007811", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR13408", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13408", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13408:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13408:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05132", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05132", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-76061", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76061", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-76066", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76066", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-76071", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76071", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LQF7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LQF7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQF7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTH4", "url": "https://www.uniprot.org/uniprotkb/F1MTH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTH4-1", "url": "https://www.uniprot.org/uniprotkb/F1MTH4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEGNAAGEPSAPGGPRPLLSGARGLIGRRPAPPLTPGRLPSIRSRDLTLGGVKKKTFTPNIISRKIKEEPKEEVTVKKEKRERDRDRQRDSHGRGRGRPEVIQSHSIFEQGPAEMMKKKGNWDKTVDMSDVGPSHIINIKKEKRETDEETKQILRMLEKDDFIDDPGLRNDIRNMPVQLPLAHSGWLFKEENEETDVQPRLAGPKEEDMEVDMPAVKVKEEPRDEDEEAKMKAPLRAARKIPGLPKDVSVAELLRELSLTQEEELLFLQLPDSLPGQPPTQDIKPIKTEVQSEDGQMVVIKQEKDREARLAENTCTLADLTEGQVGKLLIRKSGKVQLLLGKVTLDVTMGTTCSFLQELVSVGLGDSRTGDMTVLGHIKHKLVCSPTSNPCWITDTGKASRWRTVVTVPTTALLQTFCSQICSTQKGPV", "length": 430, "header": "tr|F1MTH4-1|F1MTH4_BOVIN Isoform 1 of RNA polymerase III subunit D OS=Bos taurus OX=9913 GN=POLR3D PE=4 SV=4 CANONICAL=F1MTH4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQF7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQF7/entry", "sequence": { "sequence": "MSEGNAAGEPSAPGGPRPLLSGARGLIGRRPAPPLTPGRLPSIRSRDLTLGGVKKKTFTPNIISRKIKEEPKEEVTVKKEKRERDRDRQRDSHGRGRGRPEVIQSHSIFEQGPAEMMKKKGNWDKTVDMSDVGPSHIINIKKEKRETDEETKQILRMLEKDDFIDDPGLRNDIRNMPVQLPLAHSGWLFKEENEETDVQPRLAGPKEEDMEVDMPAVKVKEEPRDEDEEAKMKAPLRAARKIPGLPKDVSVAELLRELSLTQEEELLFLQLPDSLPGQPPTQDIKPIKTEVQSEDGQMVVIKQEKDREARLAENTCTLADLTEGQVGKLLIRKSGKVQLLLGKVTLDVTMGTTCSFLQELVSVGLGDSRTGDMTVLGHIKHKLVCSPNFESLLDHRHRQILYH", "length": 403, "header": "tr|A0A3Q1LQF7-1|F1MTH4_BOVIN Computationally mapped isoform of RNA polymerase III subunit D OS=Bos taurus OX=9913 GN=POLR3D PE=4 SV=2 CANONICAL=F1MTH4-1" }, "locus": { "chromosome": "8", "start_pos": 69570756, "end_pos": 69558593, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081002.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081002.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059220.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059220.2" } ] } }, { "isoform_ac": "F1MTH4-1", "url": "https://www.uniprot.org/uniprotkb/F1MTH4/entry", "sequence": { "sequence": "MSEGNAAGEPSAPGGPRPLLSGARGLIGRRPAPPLTPGRLPSIRSRDLTLGGVKKKTFTPNIISRKIKEEPKEEVTVKKEKRERDRDRQRDSHGRGRGRPEVIQSHSIFEQGPAEMMKKKGNWDKTVDMSDVGPSHIINIKKEKRETDEETKQILRMLEKDDFIDDPGLRNDIRNMPVQLPLAHSGWLFKEENEETDVQPRLAGPKEEDMEVDMPAVKVKEEPRDEDEEAKMKAPLRAARKIPGLPKDVSVAELLRELSLTQEEELLFLQLPDSLPGQPPTQDIKPIKTEVQSEDGQMVVIKQEKDREARLAENTCTLADLTEGQVGKLLIRKSGKVQLLLGKVTLDVTMGTTCSFLQELVSVGLGDSRTGDMTVLGHIKHKLVCSPTSNPCWITDTGKASRWRTVVTVPTTALLQTFCSQICSTQKGPV", "length": 430, "header": "tr|F1MTH4-1|F1MTH4_BOVIN Isoform 1 of RNA polymerase III subunit D OS=Bos taurus OX=9913 GN=POLR3D PE=4 SV=4 CANONICAL=F1MTH4-1" }, "locus": { "chromosome": "8", "start_pos": 69564007, "end_pos": 69558593, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013251.6", "url": "https://www.ensembl.org/id/ENSBTAT00000013251.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013251.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013251.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-76061", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76061", "resource": "Reactome", "description": "RNA Polymerase III Transcription Initiation From Type 1 Promoter" }, { "id": "R-BTA-76066", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76066", "resource": "Reactome", "description": "RNA Polymerase III Transcription Initiation From Type 2 Promoter" }, { "id": "R-BTA-76071", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76071", "resource": "Reactome", "description": "RNA Polymerase III Transcription Initiation From Type 3 Promoter" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "tRNA transcription by RNA polymerase III", "id": "GO:0042797", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042797", "evidence": [ { "database": "UniProtKB", "id": "F1MTH4", "url": "https://www.uniprot.org/uniprotkb/F1MTH4" } ], "pmid": "" }, { "name": "termination of RNA polymerase III transcription", "id": "GO:0006386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006386", "evidence": [ { "database": "UniProtKB", "id": "F1MTH4", "url": "https://www.uniprot.org/uniprotkb/F1MTH4" } ], "pmid": "" }, { "name": "positive regulation of innate immune response", "id": "GO:0045089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045089", "evidence": [ { "database": "UniProtKB", "id": "F1MTH4", "url": "https://www.uniprot.org/uniprotkb/F1MTH4" } ], "pmid": "" }, { "name": "transcription initiation at RNA polymerase III promoter", "id": "GO:0006384", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006384", "evidence": [ { "database": "UniProtKB", "id": "F1MTH4", "url": "https://www.uniprot.org/uniprotkb/F1MTH4" } ], "pmid": "" }, { "name": "positive regulation of interferon-beta production", "id": "GO:0032728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032728", "evidence": [ { "database": "UniProtKB", "id": "F1MTH4", "url": "https://www.uniprot.org/uniprotkb/F1MTH4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MTH4", "url": "https://www.uniprot.org/uniprotkb/F1MTH4" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "F1MTH4", "url": "https://www.uniprot.org/uniprotkb/F1MTH4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "RNA polymerase III complex", "id": "GO:0005666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005666", "evidence": [ { "database": "UniProtKB", "id": "F1MTH4", "url": "https://www.uniprot.org/uniprotkb/F1MTH4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MTH4", "url": "https://www.uniprot.org/uniprotkb/F1MTH4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MTH4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 430, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MTH4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MTH4" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MNI1-1", "uniprot_ac": "F1MNI1", "uniprot_id": "F1MNI1_BOVIN", "mass": { "chemical_mass": 165974.0, "monoisotopic_mass": 165974.0 }, "refseq": { "ac": "XP_010810704", "name": "centrosomal protein of 164 kDa isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810704" }, "gene_names": [ { "name": "CEP164", "type": "recommended", "evidence": [ { "id": "F1MNI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI1" } ] }, { "name": "CEP164", "type": "synonym", "evidence": [ { "id": "XP_010810704", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810704" } ] } ], "protein_names": [ { "name": "Centrosomal protein of 164 kDa", "type": "recommended", "evidence": [ { "id": "F1MNI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI1/entry#names_and_taxonomy" } ] }, { "name": "centrosomal protein of 164 kDa isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010810704", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810704" } ] } ], "function": [ { "annotation": "Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1LQZ9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQZ9#function" }, { "database": "UniProtKB", "id": "ARBA00056906", "url": "https://www.uniprot.org/uniprotkb/ARBA00056906#function" }, { "database": "UniProtKB", "id": "A0A3Q1N835", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N835#function" }, { "database": "UniProtKB", "id": "F1MNI1", "url": "https://www.uniprot.org/uniprotkb/F1MNI1#function" }, { "database": "UniProtKB", "id": "A0AAA9T767", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T767#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MNI1", "url": "https://www.uniprot.org/uniprotkb/F1MNI1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEP164", "url": "https://www.uniprot.org/uniprotkb/F1MNI1", "locus": { "chromosome": "15", "start_pos": 28074377, "end_pos": 28002405, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014137", "url": "https://www.ensembl.org/id/ENSBTAG00000014137" } ] } } ], "crossref": [ { "id": "ENSBTAG00000014137", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014137", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "514284", "url": "https://www.ncbi.nlm.nih.gov/gene/514284", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein 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{ "id": "A0AAA9T767", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T767", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T767-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T767-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNI1", "url": "https://www.uniprot.org/uniprotkb/F1MNI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNI1-1", "url": "https://www.uniprot.org/uniprotkb/F1MNI1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGRPIRIGDQLVLEEDYDENYIPSEHEILEFAREIGIDPIKEPQLMWLAREGIVAPLPVEWKPCQDITGDIYYFNFANGQSTWDHPCDEHYRNLVIQERGKLSTPGATKKKEKKKKKEKEKKDKKDKETSKSPLALGSSLAPVHVPLGGLAPLRGLVDAPPSALHGPQSVSLGSSVESGQLGELLLPSQGLKPSAATKGLLGSIHEDKNALSLLALGEETNEEDEAESDNQSVRSSSELLRNLHLDIGALGGDFEYEESPRASQPEEKDVSLDSDAAGPLTSGKPFSQGADSSLSSADDKERQRREASWLPGKGKTEKNDPGTSRSGVDPGGDQPANTTEKEAPEDPVDAGEQGSRKEEAAEDPKEEASVPKESRSEVSEESEISEHGEQLQLSDSAASDPKSFLGLGFGFRSQISERLLDMDVHSSVLDGARWEAQRLGREDKDASQSSQEELQSKQSGGSERLSPPLLREERLQSLLHSQATDEGPPQAPEGQPEWKEAAEPEEGSLGSPPPSVSLQREALPSPPAAHERGQEWRPQAEGPGPGQEEPKEKVAVSPTPPGSPEVEKRACHARWSHVGKDQSWSGGERSEKEEHDPELLLGFSWDAMGEVGRSAEPAALREQLSEAALEATDEAVTRELEQEQTRLLESKQEKMQRLREKLCREEEAEALQLHQQKEKALSSLKEQLQRATEEEETQMREQERQRLSRLRAQVQSSSEADEDQIRAEQEASLQRLREELESLQKAERASLEERSRQTLEQLREEMEASEKREQAALKVEKERALQQLREQLEGERREAAAALEREHREELERLSSSLEAKHREVVSSLQKKMQEAHQKEEAQLQESLGRAEQRAHHRVYQVLEYEQELSGLLREKRQEVEREHERKMDRMKEEHQQVVAEARQQYEAEERKQRAELLGHLTGELERLRRAHERELESVRQEQDRQLEDLRRRHREQERKLQDLEVELETRTKDVKARLAQLDVQKEVARKEKQQLLDVQRQVVLESEEATATHQHLEEAKKEHTHLLESNQQLRRILEELQARKLELESQVELLQAQSQRLQKHVSDLEVQAQKKQDLLKELEVKDSNTSPHLEPDLLLEDLRRSPRTSKETDLSLDSARHYLSAEGVALRNAKEFLMQQSRSMRRRQTALKAAQQHWRQELASAQEADKDPPGTKALEDVCKDLEEETRHLDEMKSALWKGHDLLKKKEEKLHQLESSLREEASDEDMLRGPPTKKVVTFDLSDLEDGSSDSSDSCPLPRFNLTPSPTFPNKIHYLSSSLQSISSQLNGVLGVVGSLNAQPPPLFTSTPVPLPTQASRSTLAPPHPSLTRGSASSPARPTSAQWTWDPGLGPRLSSSAAQTVDDFLVEKWRKYFPTGIPFLSSGPAPLENRLGYVSASEQLRRLQHPSSRVPQVGTSNLQDMIAANRKWLEHYKNDPKLPLFSSVPKPAAGSSFLQLDLDENNRLKIYHY", "length": 1473, "header": "tr|F1MNI1-1|F1MNI1_BOVIN Isoform 1 of Centrosomal protein of 164 kDa OS=Bos taurus OX=9913 GN=CEP164 PE=4 SV=4 CANONICAL=F1MNI1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LQZ9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQZ9/entry", "sequence": { "sequence": "MAGRPIRIGDQLVLEEDYDENYIPSEHEILEFAREIGIDPIKEPQLMWLAREGIVAPLPVEWKPCQDITGDIYYFNFANGQSTWDHPCDEHYRNLVIQERGKLSTPGATKKKEKKKKKEKEKKDKKDKETSKSPLALGSSLAPVHVPLGGLAPLRGLVDAPPSALHGPQSVSLGSSVESGQLGELLLPSQGLKPSAATKGLLGSIHEDKNALSLLALGEETNEEDEAESDNQSVRSSSELLRNLHLDIGALGGDFEYEESPRASQPEEKDVSLDSDAAGPLTSGKPFSQGADSSLSSADDKERQRREASWLPGKGKTEKNDPGTSRSGVDPGGDQPANTTEKEAPEDPVDAGEQGSRKEEAAEDPKEEASVPKESRSEESEISEHGEQLQLSDSAASDPKSFLGLGFGFRSQISERLLDMDVHSSVLDGARWEAQRLGREDKDASQSSQEELQSKQSGGSERLSPPLLREERLQSLLHSQATDEGPPQAPEGQPEWKEAAEPEEGSLGSPPPSVSLQREKRACHARWSHVGKDQSWSGGERSEKEEHDPELLLGFSWDAMGEVGRSAEPAALREQLSEAALEATDEAVTRELEQEQTRLLESKQEKMQRLREKLCREEEAEALQLHQQKEKALSSLKEQLQRATEEEETQMREQERQRLSRLRAQVQSSSEADEDQIRAEQEASLQRLREELESLQKAERASLEERSRQTLEQLREEMEASEKREQAALKVEKERALQQLREQLEGERREAAAALEREHREELERLSSSLEAKHREVVSSLQKKMQEAHQKEEAQLQESLGRAEQRAHHRVYQVLEYEQELSGLLREKRQEVEREHERKMDRMKEEHQQVVAEARQQYEAEERKQRAELLGHLTGELERLRRAHERELESVRQEQDRQLEDLRRRHREQERKLQDLEVELETRTKDVKARLAQLDVQKEVARKEKQQLLDVQRQVVLESEEATATHQHLEEAKKEHTHLLESNQQLRRILEELQARKLELESQVELLQAQSQRLQKHVSDLEVQAQKKQDLLKELEVKDSNTSPHLEPDLLLEDLRRSPRTSKETDLSLDSARHYLSAEGVALRNAKEFLMQQSRSMRRRQTALKAAQQHWRQELASAQEADKDPPGTKALEDVCKDLEEETRHLDEMKSALWKGHDLLKKKEEKLHQLESSLREEASDEDMLRGPPTKKVVTFDLSDLEDGSSDSSDSCPLPRFNLTPSPTFPNKIHYLSSSLQSISSQLNGVLGVVGSLNAQPPPLFTSTPVPLPTQASRSTLAPPHPSLTRGSASSPARPTSAQWTWDPGLGPRLSSSAAQTVDDFLVEKWRKYFPTGIPFLSSGPAPLENRLGYVSASEQLRRLQHPSSRVPQVGTSNLQDMIAANRKWLEHYKNDPKLPLFSSVPKPAAGSSFLQLDLDENNRLKIYHY", "length": 1424, "header": "tr|A0A3Q1LQZ9-1|F1MNI1_BOVIN Computationally mapped isoform of Centrosomal protein of 164 kDa OS=Bos taurus OX=9913 GN=CEP164 PE=4 SV=3 CANONICAL=F1MNI1-1" }, "locus": { "chromosome": "15", "start_pos": 28073373, "end_pos": 28011130, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077390.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077390.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059403.3", "url": "https://www.ensembl.org/id/ENSBTAP00000059403.3" } ] } }, { "isoform_ac": "A0A3Q1ML76-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML76/entry", "sequence": { "sequence": "MVKISRRLEGLGLPESTREMPGQDLASVICCLAAESSRLSSEGEHEAIRAMDSGLLPWGPEPQEHPPEVDVAPAAQEACRLLPGSSPLRQGLVALSSSRGLAAEPGKMQLLDQALGSSLAPVHVPLGGLAPLRGLVDAPPSALHGPQSVSLGSSVESGQLGELLLPSQGLKPSAATKGLLGSIHEDKNALSLLALGEETNEEDEAESDNQSVRSSSELLRNLHLDIGALGGDFEYEESPRASQPEEKDVSLDSDAAGPLTSGKPFSQGADSSLSSADDKERQRREASWLPGKGKTEKNDPGTSRSGVDPGGDQPANTTEKEAPEDPVDAGEQGSRKEEAAEDPKEEASVPKESRSEESEISEHGEQLQLSDSAASDPKSFLGLGFGFRSQISERLLDMDVHSSVLDGARWEAQRLGREDKDASQSSQEELQSKQSGGSERLSPPLLREERLQSLLHSQATDEGPPQAPEGQPEWKEAAEPEEGSLGSPPPSVSLQREKRACHARWSHVGKDQSWSGGERSEKEEHDPELLLGFSWDAMGEVGRSAEPAALREQLSEAALEATDEAVTRELEQEQTRLLESKQEKMQRLREKLCREEEAEALQLHQQKEKALSSLKEQLQRATEEEETQMREQERQRLSRLRAQVQSSSEADEDQIRAEQEASLQRLREELESLQKAERASLEERSRQTLEQLREEMEASEKREQAALKVEKERALQQLREQLEGERREAAAALEREHREELERLSSSLEAKHREVVSSLQKKMQEAHQKEEAQLQESLGRAEQRAHHRVYQVLEYEQELSGLLREKRQEVEREHERKMDRMKEEHQQVVAEARQQYEAEERKQRAELLGHLTGELERLRRAHERELESVRQEQDRQLEDLRRRHREQERKLQDLEVELETRTKDVKARLAQLDVQKEVARKEKQQLLDVQRQVVLESEEATATHQHLEEAKKEHTHLLESNQQLRRILEELQARKLELESQVELLQAQSQRLQKHVSDLEVQAQKKQDLLKELEVKDSNTSPHLEPDLLLEDLRRSPRTSKETDLSLDSARHYLSAEGVALRNAKEFLMQQSRSMRRRQTALKAAQQHWRQELASAQEADKDPPGTKALEDVCKDLEEETRHLDEMKSALWKGHDLLKKKEEKLHQLESSLREEASDEDMLRGPPTKKVVTFDLSDLEDGSSDSSDSCPLPRFNLTPSPTFPNKIHYLSSSLQSISSQLNGVLGVVGSLNAQPPPLFTSTPVPLPTQASRSTLAPPHPSLTRGSASSPARPTSAQWTWDPGLGPRLSSSAAQTVDDFLVEKWRKYFPTGIPFLSSGPAPLENRLGYVSASEQLRRLQHPSSRVPQVGTSNLQDMIAANRKWLEHYKNDPKLPLFSSVPKPAAGSSFLQLDLDENNRLKIYHY", "length": 1402, "header": "tr|A0A3Q1ML76-1|F1MNI1_BOVIN Computationally mapped isoform of Centrosomal protein of 164 kDa OS=Bos taurus OX=9913 GN=CEP164 PE=4 SV=2 CANONICAL=F1MNI1-1" }, "locus": { "chromosome": "15", "start_pos": 28073373, "end_pos": 28028391, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081477.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081477.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071722.2", "url": "https://www.ensembl.org/id/ENSBTAP00000071722.2" } ] } }, { "isoform_ac": "A0A3Q1N835-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N835/entry", "sequence": { "sequence": "MAGRPIRIGDQLVLEEDYDENYIPSEHEILEFAREIGIDPIKEPQLMWLAREGIVAPLPVEWKPCQDITGDIYYFNFANGQSTWDHPCDEHYRNLVIQERGKLSTPGATKKKEKKKKKEKEKKDKKDKETSKSPLALGSSLAPVHVPLGGLAPLRGLVDAPPSALHGPQSVSLGSSVESGQLGELLLPSQGLKPSAATKGLLGSIHEDKNALSLLALGEETNEEDEAESDNQSVRSSSELLRNLHLDIGALGGDFEYEESPRASQPEEKDVSLDSDAAGPLTSGKPFSQGADSSLSSADDKERQRREASWLPGKGKTEKNDPGTSRSGVDPGGDQPANTTEKEAPEDPVDAGEQGSRKEEAAEDPKEEASVPKESRSEESEISEHGEQLQLSDSAASDPKSFLGLGFGFRSQISERLLDMDVHSSVLDGARWEAQRLGREDKDASQSSQEELQSKQSGGSEREKRACHARWSHVGKDQSWSGGERSEKEEHDPELLLGFSWDAMGEVGRSAEPAALREQLSEAALEATDEAVTRELEQEQTRLLESKQEKMQRLREKLCREEEAEALQLHQQKEKALSSLKEQLQRATEEEETQMREQERQRLSRLRAQVQSSSEADEDQIRAEQEASLQRLREELESLQKAERASLEERSRQTLEQLREEMEASEKREQAALKVEKERALQQLREQLEGERREAAAALEREHREELERLSSSLEAKHREVVSSLQKKMQEAHQKEEAQLQESLGRAEQRAHHRVYQVLEYEQELSGLLREKRQEVEREHERKMDRMKEEHQQVVAEARQQYEAEERKQRAELLGHLTGELERLRRAHERELESVRQEQDRQLEDLRRRHREQERKLQDLEVELETRTKDVKARLAQLDVQKEVARKEKQQLLDVQRQVVLESEEATATHQHLEEAKKEHTHLLESNQQLRRILEELQARKLELESQVELLQAQSQRLQKHVSDLEVQAQKKQDLLKELEVKDSNTSPHLEPDLLLEDLRRSPRTSKETDLSLDSARHYLSAEGVALRNAKEFLMQQSRSMRRRQTALKAAQQHWRQELASAQEADKDPPGTKALEDVCKDLEEETRHLDEMKSALWKGHDLLKKKEEKLHQLESSLREEASDEDMLRGPPTKKVVTFDLSDLEDGSSDSSDSCPLPRFNLTPSPTFPNKIHYLSSSLQSISSQLNGVLGVVGSLNAQPPPLFTSTPVPLPTQASRSTLAPPHPSLTRGSASSPARPTSAQWTWDPGLGPRLSSSAAQTVDDFLVEKWRKYFPTGIPFLSSGPAPLENRLGYVSASEQLRRLQHPSSRVPQVGTSNLQDMIAANRKWLEHYKNDPKLPLFSSVPKPAAGSSFLQLDLDENNRLKIYHY", "length": 1368, "header": "tr|A0A3Q1N835-1|F1MNI1_BOVIN Computationally mapped isoform of Centrosomal protein of 164 kDa OS=Bos taurus OX=9913 GN=CEP164 PE=4 SV=2 CANONICAL=F1MNI1-1" }, "locus": { "chromosome": "15", "start_pos": 28073373, "end_pos": 28011130, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069203.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069203.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067074.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067074.2" } ] } }, { "isoform_ac": "A0AAA9T767-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T767/entry", "sequence": { "sequence": "MAGRPIRIGDQLVLEEDYDENYIPSEHEILEFAREIGIDPIKEPQLMWLAREGIVAPLPVEWKPCQDITGDIYYFNFANGQSTWDHPCDEHYRNLVIQERGKLSTPGATKKKEKKKKKEKEKKDKKDKETSKSPLPSQGLKPSAATKGLLGSIHEDKNALSLLALGEETNEEDEAESDNQSVRSSSELLRNLHLDIGALGGDFEYEESPRASQPEEKDVSLDSDAAGPLTSGKPFSQGADSSLSSADDKERQRREASWLPGKGKTEKNDPGTSRSGVDPGGDQPANTTEKEAPEDPVDAGEQGSRKEEAAEDPKEEASVPKESRSEESEISEHGEQLQLSDSAASDPKSFLGLGFGFRSQISERLLDMDVHSSVLDGARWEAQRLGREDKDASQSSQEELQSKQSGGSERLSPPLLREERLQSLLHSQATDEGPPQAPEGQPEWKEAAEPEEGSLGSPPPSVSLQREALPSPPAAHERGQEWRPQAEGPGPGQEEPKEKVAVSPTPPGSPEVEKRACHARWSHVGKDQSWSGGERSEKEEHDPELLLGFSWDAMGEVGRSAEPAALREQLSEAALEATDEAVTRELEQEQTRLLESKQEKMQRLREKLCREEEAEALQLHQQKEKALSSLKEQLQRATEEEETQMREQERQRLSRLRAQVQSSSEADEDQIRAEQEASLQRLREELESLQKAERASLEERSRQTLEQLREEMEASEKREQAALKVEKERALQQLREQLEGERREAAAALEREHREELERLSSSLEAKHREVVSSLQKKMQEAHQKEEAQLQESLGRAEQRAHHRVYQVLEYEQELSGLLREKRQEVEREHERKMDRMKEEHQQVVAEARQQYEAEERKQRAELLGHLTGELERLRRAHERELESVRQEQDRQLEDLRRRHREQERKLQDLEVELETRTKDVKARLAQLDVQKEVARKEKQQLLDVQRQVVLESEEATATHQHLEEAKKEHTHLLESNQQLRRILEELQARKLELESQVELLQAQSQRLQKHVSDLEVQAQKKQDLLKELEVKDSNTSPHLEPDLLLEDLRRSPRTSKETDLSLDSARHYLSAEGVALRNAKEFLMQQSRSMRRRQTALKAAQQHWRQELASAQEADKDPPGTKALEDVCKDLEEETRHLDEMKSALWKGHDLLKKKEEKLHQLESSLREEASDEDMLRGPPTKKVVTFDLSDLEDGSSDSSDSCPLPRFNLTPSPTFPNKIHYLSSSLQSISSQLNGVLGVVGSLNAQPPPLFTSTPVPLPTQASRSTLAPPHPSLTRGSASSPARPTSAQWTWDPGLGPRLSSSAAQTVDDFLVEKWRKYFPTGIPFLSSGPAPLENRLGYVSASEQLRRLQHPSSRVPQVGTSNLQDMIAANRKWLEHYKNDPKLPLFSSVPKPAAGSSFLQLDLDENNRLKIYHY", "length": 1418, "header": "tr|A0AAA9T767-1|F1MNI1_BOVIN Computationally mapped isoform of Centrosomal protein of 164 kDa OS=Bos taurus OX=9913 GN=CEP164 PE=4 SV=1 CANONICAL=F1MNI1-1" }, "locus": { "chromosome": "15", "start_pos": 28073373, "end_pos": 28011130, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120148.2", "url": "https://www.ensembl.org/id/ENSBTAT00000120148.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093755.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093755.1" } ] } }, { "isoform_ac": "F1MNI1-1", "url": "https://www.uniprot.org/uniprotkb/F1MNI1/entry", "sequence": { "sequence": "MAGRPIRIGDQLVLEEDYDENYIPSEHEILEFAREIGIDPIKEPQLMWLAREGIVAPLPVEWKPCQDITGDIYYFNFANGQSTWDHPCDEHYRNLVIQERGKLSTPGATKKKEKKKKKEKEKKDKKDKETSKSPLALGSSLAPVHVPLGGLAPLRGLVDAPPSALHGPQSVSLGSSVESGQLGELLLPSQGLKPSAATKGLLGSIHEDKNALSLLALGEETNEEDEAESDNQSVRSSSELLRNLHLDIGALGGDFEYEESPRASQPEEKDVSLDSDAAGPLTSGKPFSQGADSSLSSADDKERQRREASWLPGKGKTEKNDPGTSRSGVDPGGDQPANTTEKEAPEDPVDAGEQGSRKEEAAEDPKEEASVPKESRSEVSEESEISEHGEQLQLSDSAASDPKSFLGLGFGFRSQISERLLDMDVHSSVLDGARWEAQRLGREDKDASQSSQEELQSKQSGGSERLSPPLLREERLQSLLHSQATDEGPPQAPEGQPEWKEAAEPEEGSLGSPPPSVSLQREALPSPPAAHERGQEWRPQAEGPGPGQEEPKEKVAVSPTPPGSPEVEKRACHARWSHVGKDQSWSGGERSEKEEHDPELLLGFSWDAMGEVGRSAEPAALREQLSEAALEATDEAVTRELEQEQTRLLESKQEKMQRLREKLCREEEAEALQLHQQKEKALSSLKEQLQRATEEEETQMREQERQRLSRLRAQVQSSSEADEDQIRAEQEASLQRLREELESLQKAERASLEERSRQTLEQLREEMEASEKREQAALKVEKERALQQLREQLEGERREAAAALEREHREELERLSSSLEAKHREVVSSLQKKMQEAHQKEEAQLQESLGRAEQRAHHRVYQVLEYEQELSGLLREKRQEVEREHERKMDRMKEEHQQVVAEARQQYEAEERKQRAELLGHLTGELERLRRAHERELESVRQEQDRQLEDLRRRHREQERKLQDLEVELETRTKDVKARLAQLDVQKEVARKEKQQLLDVQRQVVLESEEATATHQHLEEAKKEHTHLLESNQQLRRILEELQARKLELESQVELLQAQSQRLQKHVSDLEVQAQKKQDLLKELEVKDSNTSPHLEPDLLLEDLRRSPRTSKETDLSLDSARHYLSAEGVALRNAKEFLMQQSRSMRRRQTALKAAQQHWRQELASAQEADKDPPGTKALEDVCKDLEEETRHLDEMKSALWKGHDLLKKKEEKLHQLESSLREEASDEDMLRGPPTKKVVTFDLSDLEDGSSDSSDSCPLPRFNLTPSPTFPNKIHYLSSSLQSISSQLNGVLGVVGSLNAQPPPLFTSTPVPLPTQASRSTLAPPHPSLTRGSASSPARPTSAQWTWDPGLGPRLSSSAAQTVDDFLVEKWRKYFPTGIPFLSSGPAPLENRLGYVSASEQLRRLQHPSSRVPQVGTSNLQDMIAANRKWLEHYKNDPKLPLFSSVPKPAAGSSFLQLDLDENNRLKIYHY", "length": 1473, "header": "tr|F1MNI1-1|F1MNI1_BOVIN Isoform 1 of Centrosomal protein of 164 kDa OS=Bos taurus OX=9913 GN=CEP164 PE=4 SV=4 CANONICAL=F1MNI1-1" }, "locus": { "chromosome": "15", "start_pos": 28073373, "end_pos": 28011130, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018792.8", "url": "https://www.ensembl.org/id/ENSBTAT00000018792.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018792.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018792.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 560, "start_aa": "Thr", "end_pos": 560, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr560", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:514284", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:514284", "resource": "KEGG Pathway" }, { "id": "R-BTA-2565942", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2565942", "resource": "Reactome", "description": "Regulation of PLK1 Activity at G2/M Transition" }, { "id": "R-BTA-380259", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380259", "resource": "Reactome", "description": "Loss of Nlp from mitotic centrosomes" }, { "id": "R-BTA-380270", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380270", "resource": "Reactome", "description": "Recruitment of mitotic centrosome proteins and complexes" }, { "id": "R-BTA-380284", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380284", "resource": "Reactome", "description": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "id": "R-BTA-380320", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-380320", "resource": "Reactome", "description": "Recruitment of NuMA to mitotic centrosomes" }, { "id": "R-BTA-5620912", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5620912", "resource": "Reactome", "description": "Anchoring of the basal body to the plasma membrane" }, { "id": "R-BTA-8854518", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854518", "resource": "Reactome", "description": "AURKA Activation by TPX2" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MNI1", "url": "https://www.uniprot.org/uniprotkb/F1MNI1" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1MNI1", "url": "https://www.uniprot.org/uniprotkb/F1MNI1" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "F1MNI1", "url": "https://www.uniprot.org/uniprotkb/F1MNI1" } ], "pmid": "" }, { "name": "ciliary transition fiber", "id": "GO:0097539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097539", "evidence": [ { "database": "UniProtKB", "id": "F1MNI1", "url": "https://www.uniprot.org/uniprotkb/F1MNI1" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MNI1", "url": "https://www.uniprot.org/uniprotkb/F1MNI1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MNI1", "url": "https://www.uniprot.org/uniprotkb/F1MNI1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "F1MNI1", "url": "https://www.uniprot.org/uniprotkb/F1MNI1" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "F1MNI1", "url": "https://www.uniprot.org/uniprotkb/F1MNI1" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "F1MNI1", "url": "https://www.uniprot.org/uniprotkb/F1MNI1" } ], "pmid": "" }, { "name": "cell projection 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associated transcription factor 1", "type": "synonym", "evidence": [ { "id": "F1MQU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQU4/entry#names_and_taxonomy" } ] }, { "name": "bcl-2-associated transcription factor 1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005211031", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211031" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MQU4", "url": "https://www.uniprot.org/uniprotkb/F1MQU4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BCLAF1", "url": "https://www.uniprot.org/uniprotkb/F1MQU4", "locus": { "chromosome": "9", "start_pos": 74258391, "end_pos": 74287537, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007802", "url": "https://www.ensembl.org/id/ENSBTAG00000007802" } ] } } ], "crossref": [ { "id": "F1MQU4", "url": "https://alphafold.ebi.ac.uk/entry/F1MQU4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007802", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007802", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "540648", "url": "https://www.ncbi.nlm.nih.gov/gene/540648", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR029199", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029199", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LVH1", "url": "https://www.orthodb.org/?gene=A0A3Q1LVH1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MQU4", "url": "https://www.orthodb.org/?gene=F1MQU4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15268", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15268", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15268:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15268:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15440", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15440", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005211031", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211031", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVH1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LVH1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP92", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP92", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MP92-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP92-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQU4", "url": "https://www.uniprot.org/uniprotkb/F1MQU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQU4-1", "url": "https://www.uniprot.org/uniprotkb/F1MQU4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDRIYSRDYRRDYRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKNKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTITPQNAPRDEARGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEAPKEKGSEKGRAEGEWEDQEVLDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQGKNFATTSHRNTEEEGPKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTAKDKHKEDDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSSSMTLNERFTSYQKATEEHSARQKSPEIHRRIDISPSALRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSKHKSREQDHSRSSSSSASPSSPSSREEKESKKEREEEFKTHHELKEYSGFAGVSRPRGTFFRIRGRGRARGVFAGTNTGPNNSNTTFQKRPKEEEWDPEYTPKSKKYFLHDDRDDGVDYWAKRGRGRGTFQRGRGRFNFKKSGSSPKWTHDKYQGDGIVEDEEETMENNEEKKDRRKEEKE", "length": 919, "header": "tr|F1MQU4-1|F1MQU4_BOVIN Isoform 1 of BCL2 associated transcription factor 1 OS=Bos taurus OX=9913 GN=BCLAF1 PE=3 SV=3 CANONICAL=F1MQU4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LVH1-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LVH1/entry", "sequence": { "sequence": "MGRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDRIYSRDYRRDYRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKNKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTITPQNAPRDEARGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEAPKEKGSEKGRAEGEWEDQEVLDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQGKNFATTSHRNTEEEGPKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTAKDKHKEDDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSSSMTLNERFTSYQKATEEHSARQKSPEIHRRIDISPSALRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSKHKSREQDHSRSSSSSASPSSPSSREEKESKKEREEEFKTHHELKEYSGFAGVSRPRGTFHDDRDDGVDYWAKRGRGRGTFQRGRGRFNFKKSGSSPKWTHDKYQGDGIVEDEEETMENNEEKKDRRKEEKE", "length": 870, "header": "tr|A0A3Q1LVH1-1|F1MQU4_BOVIN Computationally mapped isoform of BCL2 associated transcription factor 1 OS=Bos taurus OX=9913 GN=BCLAF1 PE=3 SV=3 CANONICAL=F1MQU4-1" }, "locus": { "chromosome": "9", "start_pos": 74278097, "end_pos": 74259276, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077730.3", "url": "https://www.ensembl.org/id/ENSBTAT00000077730.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000061396.3", "url": "https://www.ensembl.org/id/ENSBTAP00000061396.3" } ] } }, { "isoform_ac": "A0A3Q1MP92-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MP92/entry", "sequence": { "sequence": "MGRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRIYSRDYRRDYRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKNKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTITPQNAPRDEARGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEAPKEKGSEKGRAEGEWEDQEVLDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQGKNFATTSHRNTEEEGPKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTAKDKHKEDDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSSSMTLNERFTSYQKATEEHSARQKSPEIHRRIDISPSALRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSKNVFVFYTAYGG", "length": 752, "header": "tr|A0A3Q1MP92-1|F1MQU4_BOVIN Computationally mapped isoform of BCL2 associated transcription factor 1 OS=Bos taurus OX=9913 GN=BCLAF1 PE=3 SV=2 CANONICAL=F1MQU4-1" }, "locus": { "chromosome": "9", "start_pos": 74278097, "end_pos": 74267819, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067405.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067405.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000073226.2", "url": "https://www.ensembl.org/id/ENSBTAP00000073226.2" } ] } }, { "isoform_ac": "F1MQU4-1", "url": "https://www.uniprot.org/uniprotkb/F1MQU4/entry", "sequence": { "sequence": "MGRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYRSRSRTYSRSRSRDRIYSRDYRRDYRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKNKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTITPQNAPRDEARGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEAPKEKGSEKGRAEGEWEDQEVLDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQGKNFATTSHRNTEEEGPKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTAKDKHKEDDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSSSMTLNERFTSYQKATEEHSARQKSPEIHRRIDISPSALRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSKHKSREQDHSRSSSSSASPSSPSSREEKESKKEREEEFKTHHELKEYSGFAGVSRPRGTFFRIRGRGRARGVFAGTNTGPNNSNTTFQKRPKEEEWDPEYTPKSKKYFLHDDRDDGVDYWAKRGRGRGTFQRGRGRFNFKKSGSSPKWTHDKYQGDGIVEDEEETMENNEEKKDRRKEEKE", "length": 919, "header": "tr|F1MQU4-1|F1MQU4_BOVIN Isoform 1 of BCL2 associated transcription factor 1 OS=Bos taurus OX=9913 GN=BCLAF1 PE=3 SV=3 CANONICAL=F1MQU4-1" }, "locus": { "chromosome": "9", "start_pos": 74278097, "end_pos": 74259276, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052712.4", "url": "https://www.ensembl.org/id/ENSBTAT00000052712.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052174.3", "url": "https://www.ensembl.org/id/ENSBTAP00000052174.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MQU4", "url": "https://www.uniprot.org/uniprotkb/F1MQU4" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": 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"https://www.ebi.ac.uk/interpro/entry/pfam/PF14465", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25793", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25793", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5689603", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689603", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5696394", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696394", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002699276", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699276", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWT0", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LWT0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LWT0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPR9", "url": "https://www.uniprot.org/uniprotkb/F1MPR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPR9-1", "url": "https://www.uniprot.org/uniprotkb/F1MPR9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSLDHMLTDPLELGPCGDGQGSRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQFLPLFPEDSMEQQNQLILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFRSQYKRYLSSQQQYFHRLLKQILASRSDLLEMARRSGPAFPSRQKRPWPSRAPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKIELGDSDLKIMLKKHHEKRKYQPDHPDLLTGDLTLNDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEERKKKKIKLIKSEVEDLAEPLSGPEGLPPLSQAPSPLAIPAIKEEPLEDLKPCLGINEISSSFFSLLLEILLLEGQASLPLLEERVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQHWKLLGQSQDNEKELAALFQLWLETKDQAFCKQETEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKPPSKVKSSSKDGPVKVLSGGPSEQSQLSLSDSSMPPTPVTPVTPTTPALPATPISPPPVPPVNKNGPTTVSEPAKSTSGVLLVSSPTMPQLGTMLSPASSQTPPSSQAAARVVSHSGSAGLPQVRVVAPPSLPAVTQPAGPAPPLPPMPAGTQIRMPATGAQAKGGPQTVMATVPVKAQTATATVQRPGPGSAGLTVTSLPAAAKPTSKPATSSPGGPTPSTPTAAVLQSVAGQNIIKQVAITGQLGVKPQTGSSVPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGTGAGTTGKGISATLHVTSNPVHATDSPAKAGVATAPSSTPTGTTVVKVTPDLKPARLMPALGVSVADQKGKNTVASSEAKPAATIRIVQGLGVMPPTAGQTITVAAHTKQGPSVAGGSGTVHTSAVSMPSVNAAVSKTVAVASGAASAPISIGTGAPAVRQVPVSTAVVSTSQAGKLPTRITVPLSVISQPMKGKSVVTAPIIKGNLGANLGGLGRNIILTTMPAGAKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ", 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{ "isoform_ac": "F1MPR9-1", "url": "https://www.uniprot.org/uniprotkb/F1MPR9/entry", "sequence": { "sequence": "MDSLDHMLTDPLELGPCGDGQGSRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQFLPLFPEDSMEQQNQLILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFRSQYKRYLSSQQQYFHRLLKQILASRSDLLEMARRSGPAFPSRQKRPWPSRAPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKIELGDSDLKIMLKKHHEKRKYQPDHPDLLTGDLTLNDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEERKKKKIKLIKSEVEDLAEPLSGPEGLPPLSQAPSPLAIPAIKEEPLEDLKPCLGINEISSSFFSLLLEILLLEGQASLPLLEERVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQHWKLLGQSQDNEKELAALFQLWLETKDQAFCKQETEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKPPSKVKSSSKDGPVKVLSGGPSEQSQLSLSDSSMPPTPVTPVTPTTPALPATPISPPPVPPVNKNGPTTVSEPAKSTSGVLLVSSPTMPQLGTMLSPASSQTPPSSQAAARVVSHSGSAGLPQVRVVAPPSLPAVTQPAGPAPPLPPMPAGTQIRMPATGAQAKGGPQTVMATVPVKAQTATATVQRPGPGSAGLTVTSLPAAAKPTSKPATSSPGGPTPSTPTAAVLQSVAGQNIIKQVAITGQLGVKPQTGSSVPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGTGAGTTGKGISATLHVTSNPVHATDSPAKAGVATAPSSTPTGTTVVKVTPDLKPARLMPALGVSVADQKGKNTVASSEAKPAATIRIVQGLGVMPPTAGQTITVAAHTKQGPSVAGGSGTVHTSAVSMPSVNAAVSKTVAVASGAASAPISIGTGAPAVRQVPVSTAVVSTSQAGKLPTRITVPLSVISQPMKGKSVVTAPIIKGNLGANLGGLGRNIILTTMPAGAKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ", "length": 1291, "header": "tr|F1MPR9-1|F1MPR9_BOVIN Isoform 1 of Nuclear factor related to kappa-B-binding protein OS=Bos taurus OX=9913 GN=NFRKB PE=3 SV=3 CANONICAL=F1MPR9-1" }, "locus": { "chromosome": "29", "start_pos": 36097394, "end_pos": 36070021, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061387.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061387.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053560.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053560.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 721, "start_aa": "Thr", "end_pos": 721, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr721", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 726, "start_aa": "Thr", "end_pos": 726, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr726", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 900, "start_aa": "Thr", "end_pos": 900, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr900", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510304", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510304", "resource": "KEGG Pathway" }, { "id": "R-BTA-5689603", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5689603", "resource": "Reactome", "description": "UCH proteinases" }, { "id": "R-BTA-5696394", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5696394", "resource": "Reactome", "description": "DNA Damage Recognition in GG-NER" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M2B866-1", "protein_name": "Nuclear factor related to kappa-B-binding protein", "gene_name": "nfrkb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDALDHMLTDPLESAMDQDGRVMEECMLGNCRVRVPEDLLEDPEIFFSVLSESTWTDVLTEAQRTHLRQLLPQFPEENMAEQNSIIGDLFNNKNFLFGNPLHIAQKLFRDGHFNPEVVKYRQLCAKSQKKRQIYSLQQYYHKLLKQILVSRKELLDLAVRSGPELAVKRRYPAASHKEMLEQRVRRRVGHIIKDVKTECGDSNVSSDEDDSSSWLPVPQSPSSPTPTFSLRVLPSLSTQDMKTRDKPELGEKELRAMLHRHREKRKRQPDHPDLMTSDLHLGDIMSRVNIGRKGSVTVFDLAIPKKKIKEEKRKKKMRPIKMESEEVCDVQMSAPPMNPGLTDVPAAPPQSVKEEPIDEPQTSPDTVEEIAMSFFHLLEDILRLEGLATSSTMEEKVQQWQSSPASTLNPWFSMAPCWSEVVVPALQFLAGESKAGVMALPTGFIPFVEFKEVSQQWKWIGSSQDGDKDLSALCQLWLESKDHVIVKQEGEETAELTPPTPRVWTDYVVRPSTGEERHVFQEQEQQRYDQPHKAFTYRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSAQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSQEEFERIHQAQAAAAKAKKALQQKPKPAPKPKAGGKEPGSKNGIAEAGQSTSNEGIAIAATSLSQTPSTPTQSTPGTPKSPLPPTSATPTKVAAPEPIKTNPSVLLVSPPTMPQLGTLLSASQPSPQVSQQASPQSATRVVAHSAATGSLPQVRVVTAQPSLHTSTAGQAATLVHQSPHHIRVPVTVAHGKNITQAVVTLPLRNQSAGSPIQVQASRGQASLTVPGLASAVTVTKPQTSSPASPAHNQTAPAVLQGVSSQSIIKQVAITGQLGVKTQSGAGIPLTATNLRIQGKDVLRLPPSSITTDAKGQTVLRITPDMMATLTKSPVATVKLTPDMLSSATSSGSKSISATLHVSQPQPSPPTSSTTASENLAVKTPATLVKVHPELKTACDTAIRLMPALAVTMADSKARTFSTVTSSDSKAGTTIRIVPNLGVIPQKQGQAVSIATTTTSTKPITVSSGAATVTIATSGVAGAKGVTLGTAGTGSTLSLGTAAATVRQVPVSATVVTTQTGKLPTRITVPLSVLSQPLKNKSVVTTPILKGNISTNISNLGRNIILTTMPAGTKLIAGNKPVSFVTAQQLQQLQQQGQATQVRIQTVPAQQLQRTAASSPKSTVSTVVVSTAPSPKTNPDPQ", "length": 1290 }, "evidence": [ { "id": "F1MPR9", "url": "https://omabrowser.org/oma/group/F1MPR9/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V0ZSK7-1", "protein_name": "Nuclear factor related to kappa-B-binding protein", "gene_name": "NFRKB", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDSLDHMLTDPLELGPCGDGNGARIMEDCLLGTTRVSLPEDLLEDPEIFFEVVSLSTWQEVLTDAQQEHLKTFLPHFPENNREHQNKIISALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCLKSQYKRYLSSQQQYFYRLLKQILASRNHLLELARKGGPDMILKRKHFSPSYDAEEREKRTHRRYLKILREVKEECGDTTLSSDEEDLSSWPPSSPSRCPSPPIPLRVIPTLSTMDMKTADRIELGESDLKMMLRKHREKRKYQPDHPDLVTADITLEDVMTRVNAGRKGSLAALFDLATFKKKVKEKDDKKKKKLKIIKSEVEDLTDSFSSAHGIPSLSQDHSPIPLSSVKEEPLEEMKPCLGINEISSSFFFLLLEILFLEGPASLSVLEDKVIDWQTSPASALNTWFSFAPNWSELVLPALQYLTGDSRDVPSSFSPFVEFKEKTQQWKLLGSCQDHEKELAALFQLWLETKDQTFFKENEDSSDATTPIPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSAQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKAKKALQQKPKPPAKVKSSNKESSVKALPSSTSEPSQLSLSDSSMPPTPVTPVTPTAPALPATPISPPPVSVVSKSVPSAGSEPAKPSQSVLLVSSPTMPQLGTLLSTAQSSQTQPGPQPPPTRVVSHTASSVLPQVRVVSAQSSLPAVSQQAPVVTQQQQQPTSVPQIRVPATATQTKVLPQAVMTLPVKAQTSPVQVQRQGTSVTGQTGITVTGLSAAPSPAVKAVTSSPGSSATSTSSTTVIQNVAGQNIIKQVAITGQLGMKTQPGSSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFTAAAGSSASGKGISATLHVTSNPVQTADSPAKTSTASSSSSPAGSTVVKVTPDLKTTEPTSSAFRLMPALGMTVADQKSKAITTVASTEAKPAATIRIVQGLGVMPPKAGQTITVATHAKQVPSSAAVSVPGTVHTSAVSLPTMSATVSKAVAVASGAAGTPITIGTGGTAVRQVPVSTTVVSTSQAGKLPARITVPLSVISQPVKGKSVVTAPIIKGNLGANISGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVPASHLQQGTVSGSAKAVSTVVVTTAPSPKQSQDQL", "length": 1308 }, "evidence": [ { "id": "F1MPR9", "url": "https://omabrowser.org/oma/group/F1MPR9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q6P4R8-1", "protein_name": "Nuclear factor related to kappa-B-binding protein", "gene_name": "NFRKB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPEDSAEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPALPFRQKRPSPSRTPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKVELGDSDLKIMLKKHHEKRKHQPDHPDLLTGDLTLNDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKKIKTIKSEAEDLAEPLSSTEGVAPLSQAPSPLAIPAIKEEPLEDLKPCLGINEISSSFFSLLLEILLLESQASLPMLEERVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFQLWLETKDQAFCKQENEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKPPSKVKSSSKESSIKVLSSGPSEQSQMSLSDSSMPPTPVTPVTPTTPALPAIPISPPPVSAVNKSGPSTVSEPAKSSSGVLLVSSPTMPHLGTMLSPASSQTAPSSQAAARVVSHSGSAGLSQVRVVAQPSLPAVPQQSGGPAQTLPQMPAGPQIRVPATATQTKVVPQTVMATVPVKAQTTAATVQRPGPGQTGLTVTSLPATASPVSKPATSSPGTSAPSASTAAVIQNVTGQNIIKQVAITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGTGGNTTGKGISATLHVTSNPVHAADSPAKASSASAPSSTPTGTTVVKVTPDLKPTEASSSAFRLMPALGVSVADQKGKSTVASSEAKPAATIRIVQGLGVMPPKAGQTITVATHAKQGASVASGSGTVHTSAVSLPSMNAAVSKTVAVASGAASTPISISTGAPTVRQVPVSTTVVSTSQAGKLPTRITVPLSVISQPMKGKSVVTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ", "length": 1299 }, "evidence": [ { "id": "F1MPR9", "url": "https://omabrowser.org/oma/group/F1MPR9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Ino80 complex", "id": "GO:0031011", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031011", "evidence": [ { "database": "UniProtKB", "id": "F1MPR9", "url": "https://www.uniprot.org/uniprotkb/F1MPR9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protease binding", "id": "GO:0002020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002020", "evidence": [ { "database": "UniProtKB", "id": "F1MPR9", "url": "https://www.uniprot.org/uniprotkb/F1MPR9" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MPR9", "url": "https://www.uniprot.org/uniprotkb/F1MPR9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "telomere maintenance", "id": "GO:0000723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000723", "evidence": [ { "database": "UniProtKB", "id": "F1MPR9", "url": "https://www.uniprot.org/uniprotkb/F1MPR9" } ], "pmid": "" }, { "name": "positive regulation of DNA repair", "id": "GO:0045739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045739", "evidence": [ { "database": "UniProtKB", "id": "F1MPR9", "url": "https://www.uniprot.org/uniprotkb/F1MPR9" } ], "pmid": "" }, { "name": "regulation of embryonic development", "id": "GO:0045995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045995", "evidence": [ { "database": "UniProtKB", "id": "F1MPR9", "url": "https://www.uniprot.org/uniprotkb/F1MPR9" } ], "pmid": "" }, { "name": "positive regulation of telomere maintenance in response to DNA damage", "id": "GO:1904507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904507", "evidence": [ { "database": "UniProtKB", "id": "F1MPR9", "url": "https://www.uniprot.org/uniprotkb/F1MPR9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MPR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPR9" }, { "id": "PS51916", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51916" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DEUBAD", "eco_id": "ECO_0000259", "start_pos": 39, "end_pos": 156, "start_aa": "Pro", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 721, 726, 900 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MLY5-1", "uniprot_ac": "F1MLY5", "uniprot_id": "F1MLY5_BOVIN", "mass": { "chemical_mass": 123459.0, "monoisotopic_mass": 123459.0 }, "refseq": {}, "gene_names": [ { "name": "CISD3", "type": "recommended", "evidence": [ { "id": "F1MLY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ] }, { "name": "MLLT6", "type": "recommended", "evidence": [ { "id": "F1MLY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ] }, { "name": "CISD3", "type": "synonym", "evidence": [ { "id": "F1MLY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ] } ], "protein_names": [ { "name": "MLLT6, PHD finger containing", "type": "synonym", "evidence": [ { "id": "F1MLY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MLY5", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MLLT6", "url": "https://www.uniprot.org/uniprotkb/F1MLY5", "locus": { "chromosome": "19", "start_pos": 39328191, "end_pos": 39301751, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011532", "url": "https://www.ensembl.org/id/ENSBTAG00000011532" } ] } } ], "crossref": [ { "id": "F1MLY5", "url": "https://alphafold.ebi.ac.uk/entry/F1MLY5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011532", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011532", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000046569", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000046569", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15574", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15574", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15709", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15709", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538601", "url": "https://www.ncbi.nlm.nih.gov/gene/538601", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "618350", "url": "https://www.ncbi.nlm.nih.gov/gene/618350", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018967", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018967", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034732", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034732", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042216", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042216", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050701", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050701", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052950", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052950", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:618350", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618350", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1LXC9", "url": "https://www.orthodb.org/?gene=A0A3Q1LXC9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MLY5", "url": "https://www.orthodb.org/?gene=F1MLY5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3MWJ2", "url": "https://www.orthodb.org/?gene=G3MWJ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13793", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13793", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13793:SF90", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13793:SF90", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46491", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46491", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46491:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46491:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09360", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09360", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13831", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13831", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13832", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13832", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LXC9", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LXC9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1B2", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1B2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0P1B2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1B2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLY5", "url": "https://www.uniprot.org/uniprotkb/F1MLY5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLY5-1", "url": "https://www.uniprot.org/uniprotkb/F1MLY5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MWJ2", "url": "https://www.uniprot.org/uniprotkb/G3MWJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3MWJ2-1", "url": "https://www.uniprot.org/uniprotkb/G3MWJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKEMVGGCCVCSDERGWAENPLVYCDGHACSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVLTMEPIVLQYVPHDRFNKTCYICEEQGRESKAASGACMTCNRHGCRQAFHVTCAQMAGLLCEEEVLEVDNVKYCGYCKYHFSKMKTSRHSSGGGGGSGGTGGGGGSTGGGSSSFIAGRRSRSASPSAQQEKHPSHHERGQKKSRKDKERLKQKHKKRPESPSILTPPVVPTADKVSSSASSSSHHEASTQETSEGSRDSKGKKSSSHSLSHKGKKLSSGKGVSCFTSASSSSSSSSSSSSGGPFQPTVSSLQSSPDFSAFPKLEQPEEDKYSKPTAPPPSAPPSPSAPEPPKADLFEQKVVFSGFGPIMRFSTTTSSSGRARAPSPGDYKSPHVSGSGASGGTHKRMPTLSATPVPAEETPETGLKEKKHKASKKSRHGPGRPKGSRNKEGPGGPALPSLPGAQLAGFTATAASPFSGGSLVSSGLGGLASRTFGPSGSLPSLSLESPLLGAGIYTSNKDPISHGGGMLRAVCSTPLSSSLLGPPGTSALPRLSRSPFTSTLPSSSASISTTQVFSLAGSTFSLPSTHIFGTPMGAVNPLLTQAESSHTEPDLEDCSFRCRGTSPQESLSSMSPISSLPALFDQTASAPCGGGQLDPAAPGTTNMEQLLEKQGDGEAGVNIVEMLKALHALQKENQRLQEQILSLTAKKERLQILNVQLSVPFAALPAALPATNGPVPGPYGLPPQAGSSDSLSTSKSPPGKNSLGLDNSLSTSSEDPHSGCPSRSSSSLSFHSTPPPLPLLQQSPATLPLALPGGPAPLPPQPQNGLGRAPGAAGLGAMPMAEGLLGGLAGSGALPLNGLLGGLNGAAAPNPAGLSQAGGAPTLQLPGCLNSLTEQQRHLLQQQEQQLQQLQQLLASPQLTPEHQTVVYQMIQQIQQKRELQRLQMAGGSQLPMASLLAGSSTPLLSAGTPGLLPTASAPPLLPAGALVAPSLGNNTSLMAAAAAAAAVAAAGGPPVLTAQTNPFLSLSGADGSASGPKGGTLNQRRDITSWLARWFPKTPAKSVVALKTPIKVELVAGKTYRWCVCGRSKKQPFCDGSHFFKRTGLSPLKFKAQETRTVALCTCKATQKPPYCDGTHRSEQVQKAELGSSL", "length": 1193, "header": "tr|F1MLY5-1|F1MLY5_BOVIN Isoform 1 of MLLT6, PHD finger containing OS=Bos taurus OX=9913 GN=MLLT6 PE=4 SV=4 CANONICAL=F1MLY5-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LXC9-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXC9/entry", "sequence": { "sequence": "MKEMVGGCCVCSDERGWAENPLVYCDGHACSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVLTMEPIVLQYVPHDRFNKTCYICEEQGRESKAASGACMTCNRHGCRQAFHVTCAQMAGLLCEEEVLEVDNVKYCGYCKYHFSKMSRKDKERLKQKHKKRPESPSILTPPVVPTADKVSSSASSSSHHEASTQETSEGSRDSKGKKSSSHSLSHKGKKLSSGKGVSCFTSASSSSSSSSSSSSGGPFQPTVSSLQSSPDFSAFPKLEQPEEDKYSKPTAPPPSAPPSPSAPEPPKADLFEQKVVFSGFGPIMRFSTTTSSSGRARAPSPGDYKSPHVSGSGASGGTHKRMPTLSATPVPAEETPETGLKEKKHKASKKSRHGPGRPKGSRNKEGPGGPALPSLPGAQLAGFTATAASPFSGGSLVSSGLGGLASRTFGPSGSLPSLSLESPLLGAGIYTSNKDPISHGGGMLRAVCSTPLSSSLLGPPGTSALPRLSRSPFTSTLPSSSASISTTQVFSLAGSTFSLPSTHIFGTPMGAVNPLLTQAESSHTEPDLEDCSFRCRGTSPQESLSSMSPISSLPALFDQTASAPCGGGQLDPAAPGTTNMEQLLEKQGDGEAGVNIVEMLKALHALQKENQRLQEQILSLTAKKERLQILNVQLSVPFAALPAALPATNGPVPGPYGLPPQAGSSDSLSTSKSPPGKNSLGLDNSLSTSSEDPHSGCPSRSSSSLSFHSTPPPLPLLQQSPATLPLALPGGPAPLPPQPQNGLGRAPGAAGLGAMPMAEGLLGGLAGSGALPLNGLLGGLNGAAAPNPAGLSQAGGAPTLQLPGCLNSLTEQQRHLLQQQEQQLQQLQQLLASPQLTPEHQTVVYQMIQQIQQKRELQRLQMAGGSQLPMASLLAGSSTPLLSAGTPGLLPTASAPPLLPAGALVAPSLGNNTSLMAAAAAAAAVAAAGGPPVLTAQTNPFLSLSGADGSASGPKGGTADKGASANQEKG", "length": 1037, "header": "tr|A0A3Q1LXC9-1|F1MLY5_BOVIN Computationally mapped isoform of MLLT6, PHD finger containing OS=Bos taurus OX=9913 GN=MLLT6 PE=4 SV=1 CANONICAL=F1MLY5-1" }, "locus": { "chromosome": "19", "start_pos": 39320538, "end_pos": 39301950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082897.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082897.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065415.1", "url": "https://www.ensembl.org/id/ENSBTAP00000065415.1" } ] } }, { "isoform_ac": "A0ABI0P1B2-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P1B2/entry", "sequence": { "sequence": "MKEMVGGCCVCSDERGWAENPLVYCDGHACSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVLTMEPIVLQYVPHDRFNKTCYICEEQGRESKAASGACMTCNRHGCRQAFHVTCAQMAGLLCEEEVLEVDNVKYCGYCKYHFSKMKTSRHSSGGGGGSGGTGGGGGSTGGGSSSFIAGRRSRSASPSAQQEKHPSHHERGQKKSRKDKERLKQKHKKRPESPSILTPPVVPTADKVSSSASSSSHHEASTQETSEGSRDSKGKKSSSHSLSHKGKKLSSGKGVSCFTSASSSSSSSSSSSSGGPFQPTVSSLQSSPDFSAFPKLEQPEEDKYSKPTAPPPSAPPSPSAPEPPKADLFEQKVVFSGFGPIMRFSTTTSSSGRARAPSPGDYKSPHVSGSGASGGTHKRMPTLSATPVPAEETPETGLKEKKHKASKKSRHGPGRPKGSRNKEGPGGPALPSLPGAQLAGFTATAASPFSGGSLVSSGLGGLASRTFGPSGSLPSLSLESPLLGAGIYTSNKDPISHGGGMLRAVCSTPLSSSLLGPPGTSALPRLSRSPFTSTLPSSSASISTTQVFSLAGSTFSLPSTHIFGTPMGAVNPLLTQAESSHTEPDLEDCSFRCRGTSPQESLSSMSPISSLPALFDQTASAPCGGGQLDPAAPGTTNMEQLLEKQGDGEAGVNIVEMLKALHALQKENQRLQEQILSLTAKKERLQILNVQLSVPFAALPAALPATNGPVPGPYGLPPQAGSSDSLSTSKSPPGKNSLGLDNSLSTSSEDPHSGCPSRSSSSLSFHSTPPPLPLLQQSPATLPLALPGGPAPLPPQPQNGLGRAPGAAGLGAMPMAEGLLGGLAGSGALPLNGLLGGLNGAAAPNPAGLSQAGGAPTLQLPGCLNSLTEQQRHLLQQQEQQLQQLQQLLASPQLTPEHQTVVYQMIQQIQQKRELQRLQMAGGSQLPMASLLAGSSTPLLSAGTPGLLPTASAPPLLPAGALVAPSLGNNTSLMAAAAAAAAVAAAGGPPVLTAQTNPFLSLSGADGSASGPKGGTADKGASANQEKG", "length": 1095, "header": "tr|A0ABI0P1B2-1|A0ABI0P1B2_BOVIN Computationally mapped isoform of MLLT6, PHD finger containing OS=Bos taurus OX=9913 GN=CISD3 PE=4 SV=1 CANONICAL=F1MLY5-1" }, "locus": { "chromosome": "19", "start_pos": 39320538, "end_pos": 39301950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145776.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145776.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104051.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104051.1" } ] } }, { "isoform_ac": "F1MLY5-1", "url": "https://www.uniprot.org/uniprotkb/F1MLY5/entry", "sequence": { "sequence": "MKEMVGGCCVCSDERGWAENPLVYCDGHACSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVLTMEPIVLQYVPHDRFNKTCYICEEQGRESKAASGACMTCNRHGCRQAFHVTCAQMAGLLCEEEVLEVDNVKYCGYCKYHFSKMKTSRHSSGGGGGSGGTGGGGGSTGGGSSSFIAGRRSRSASPSAQQEKHPSHHERGQKKSRKDKERLKQKHKKRPESPSILTPPVVPTADKVSSSASSSSHHEASTQETSEGSRDSKGKKSSSHSLSHKGKKLSSGKGVSCFTSASSSSSSSSSSSSGGPFQPTVSSLQSSPDFSAFPKLEQPEEDKYSKPTAPPPSAPPSPSAPEPPKADLFEQKVVFSGFGPIMRFSTTTSSSGRARAPSPGDYKSPHVSGSGASGGTHKRMPTLSATPVPAEETPETGLKEKKHKASKKSRHGPGRPKGSRNKEGPGGPALPSLPGAQLAGFTATAASPFSGGSLVSSGLGGLASRTFGPSGSLPSLSLESPLLGAGIYTSNKDPISHGGGMLRAVCSTPLSSSLLGPPGTSALPRLSRSPFTSTLPSSSASISTTQVFSLAGSTFSLPSTHIFGTPMGAVNPLLTQAESSHTEPDLEDCSFRCRGTSPQESLSSMSPISSLPALFDQTASAPCGGGQLDPAAPGTTNMEQLLEKQGDGEAGVNIVEMLKALHALQKENQRLQEQILSLTAKKERLQILNVQLSVPFAALPAALPATNGPVPGPYGLPPQAGSSDSLSTSKSPPGKNSLGLDNSLSTSSEDPHSGCPSRSSSSLSFHSTPPPLPLLQQSPATLPLALPGGPAPLPPQPQNGLGRAPGAAGLGAMPMAEGLLGGLAGSGALPLNGLLGGLNGAAAPNPAGLSQAGGAPTLQLPGCLNSLTEQQRHLLQQQEQQLQQLQQLLASPQLTPEHQTVVYQMIQQIQQKRELQRLQMAGGSQLPMASLLAGSSTPLLSAGTPGLLPTASAPPLLPAGALVAPSLGNNTSLMAAAAAAAAVAAAGGPPVLTAQTNPFLSLSGADGSASGPKGGTLNQRRDITSWLARWFPKTPAKSVVALKTPIKVELVAGKTYRWCVCGRSKKQPFCDGSHFFKRTGLSPLKFKAQETRTVALCTCKATQKPPYCDGTHRSEQVQKAELGSSL", "length": 1193, "header": "tr|F1MLY5-1|F1MLY5_BOVIN Isoform 1 of MLLT6, PHD finger containing OS=Bos taurus OX=9913 GN=MLLT6 PE=4 SV=4 CANONICAL=F1MLY5-1" }, "locus": { "chromosome": "19", "start_pos": 39327753, "end_pos": 39301950, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015325.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015325.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015325.7", "url": "https://www.ensembl.org/id/ENSBTAP00000015325.7" } ] } }, { "isoform_ac": "G3MWJ2-1", "url": "https://www.uniprot.org/uniprotkb/G3MWJ2/entry", "sequence": { "sequence": "MGSVRGVGTLVRPAAWTLNQRRDITSWLARWFPKTPAKSVVALKTPIKVELVAGKTYRWCVCGRSKKQPFCDGSHFFKRTGLSPLKFKAQETRTVALCTCKATQKPPYCDGTHRSEQVQKAELGSSL", "length": 127, "header": "tr|G3MWJ2-1|F1MLY5_BOVIN Computationally mapped isoform of MLLT6, PHD finger containing OS=Bos taurus OX=9913 GN=MLLT6 PE=4 SV=3 CANONICAL=F1MLY5-1" }, "locus": { "chromosome": "19", "start_pos": 39327753, "end_pos": 39325017, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000065758.4", "url": "https://www.ensembl.org/id/ENSBTAT00000065758.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053892.3", "url": "https://www.ensembl.org/id/ENSBTAP00000053892.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:618350", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:618350", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MLY5", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MLY5", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MLY5", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "F1MLY5", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ], "pmid": "" }, { "name": "nucleosome binding", "id": "GO:0031491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031491", "evidence": [ { "database": "UniProtKB", "id": "F1MLY5", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ], "pmid": "" }, { "name": "2 iron, 2 sulfur cluster binding", "id": "GO:0051537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051537", "evidence": [ { "database": "UniProtKB", "id": "F1MLY5", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ], "pmid": "" }, { "name": "histone reader activity", "id": "GO:0140566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140566", "evidence": [ { "database": "UniProtKB", "id": "F1MLY5", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MLY5", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1MLY5", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "F1MLY5", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MLY5", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1036, "end_pos": 1038, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1037, "end_pos": 1039, "annotation": "n_glycosylation_sequon" }, { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MLY5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1193, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MLY5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MLY5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MLY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY5" }, { "id": "PS50016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50016" }, { "id": "PS51805", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51805" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PHD-type", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 57, "start_aa": "Val", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1036, "end_pos": 1038 }, { "start_pos": 1037, "end_pos": 1039 }, { "start_pos": 117, "end_pos": 119 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMD7-1", "uniprot_ac": "F1MMD7", "uniprot_id": "F1MMD7_BOVIN", "mass": { "chemical_mass": 101513.0, "monoisotopic_mass": 101513.0 }, "refseq": {}, "gene_names": [ { "name": "ITIH4", "type": "recommended", "evidence": [ { "id": "F1MMD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD7" } ] } ], "protein_names": [ { "name": "Inter-alpha-trypsin inhibitor heavy chain 4", "type": "synonym", "evidence": [ { "id": "F1MMD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMD7", "url": "https://www.uniprot.org/uniprotkb/F1MMD7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ITIH4", "url": "https://www.uniprot.org/uniprotkb/F1MMD7", "locus": { "chromosome": "22", "start_pos": 48074584, "end_pos": 48059589, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007850", "url": "https://www.ensembl.org/id/ENSBTAG00000007850" } ] } } ], "crossref": [ { "id": "F1MMD7", "url": "https://alphafold.ebi.ac.uk/entry/F1MMD7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007850", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007850", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01461", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01461", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "513700", "url": "https://www.ncbi.nlm.nih.gov/gene/513700", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010600", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010600", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013694", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013694", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050934", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050934", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZ09", "url": "https://www.orthodb.org/?gene=A0A3Q1LZ09", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MA31", "url": "https://www.orthodb.org/?gene=A0A3Q1MA31", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MMD7", "url": "https://www.orthodb.org/?gene=F1MMD7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10338", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10338", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10338:SF119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10338:SF119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00092", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00092", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06668", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06668", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08487", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08487", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1LZ09", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1LZ09-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA31", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA31", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MA31-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA31-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXG7", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXG7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXG7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXG7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMD7", "url": "https://www.uniprot.org/uniprotkb/F1MMD7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMD7-1", "url": "https://www.uniprot.org/uniprotkb/F1MMD7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKTPAPGRIHSIVLVLLSLAVLQTSKAQKVQNDIDIYSLTVDSKVSSRFAHTVITSRVVNKADAVREATFQMELPKKAFITNFSMVIDGVTYPGNIKEKAAAQEQYSAAVARGESAGLVRATGRKTEQFQVSVSVAPAAKVTFELVYEELLARHLGAYELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNKLAEALTTSQNKTKAHVRFKPTLSQQQKYPEKQDTVLDGSFIVRYDVDRPLSGGSIQIENGYFVHYFAPDSLSTIPKNVIFVIDKSGSMMGRKIKQTREALIKILDDLSPHDQFDLISFSSEATTWKPLLVPASTENVNEAKSYATGIQAQGGTNINDAMLMAVQLLEKANQEELLPEGSITLIILLTDGDPTVGETNPLNIQKNVRKAINGQHSLFCLGFGFDVSYAFLEKMALENGGLARRIYEDSDSALQLQDFYQEVANPLMTSVAFEYPSNAVESVTQDTFRVFFKGSELVVAGKLREQSPDVLLAQIRGQLHRENITYMMMSHVAEQEEMFRSPKYIFHSFIERLWAYLTIQQLLEQMVSALDAEKQALEARALSLSLSYSFVTPLTSMVITKPEGQEQSQVAEKPVEDESRGSRVYLGPMRFGHSVGDRTSRKPGGGLKLLNGTPLFGPPGPPAAASPFHRMTSRLVLPELMSPLAPASAPSPTSGPGGASHDTDFRIKGTTPTALPFAPVQAPSVILPLPGQSVDRLCVDLRRPQELVNLLSDPDQGVEVTGHFETAKARFSWIEVTFENPQVQIHASPEHVVMTRNRRNSAYKWKETLYSVMPGLKVTMDKEGLLLLSRPDRVTIGLLFWDGPGKGLRLLLQNTDRFSSHVSGTLGQFYQDVLWGPLDTADDSKRTLKVQGRDYSATRELKLDYQESPPGKEISCWSVEL", "length": 916, "header": "tr|F1MMD7-1|F1MMD7_BOVIN Isoform 1 of Inter-alpha-trypsin inhibitor heavy chain 4 OS=Bos taurus OX=9913 GN=ITIH4 PE=3 SV=3 CANONICAL=F1MMD7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZ09-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ09/entry", "sequence": { "sequence": "IKHLTVDSKVSSRFAHTVITSRVVNKADAVREATFQMELPKKAFITNFSMVIDGVTYPGNIKEKAAAQEQYSAAVARGESAGLVRATGRKTEQFQVSVSVAPAAKVTFELVYEELLARHLGAYELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNKLAEALTTSQNKTKAHVRFKPTLSQQQKYPEKQDTVLDGSFIVRYDVDRPLSGGSIQIENGYFVHYFAPDSLSTIPKNVIFVIDKSGSMMGRKIKQTREALIKILDDLSPHDQFDLISFSSEATTWKPLLVPASTENVNEAKSYATGIQAQGGTNINDAMLMAVQLLEKANQEELLPEGSITLIILLTDGDPTVGETNPLNIQKNVRKAINGQHSLFCLGFGFDVSYAFLEKMALENGGLARRIYEDSDSALQLQDFYQEVANPLMTSVAFEYPSNAVESVTQDTFRVFFKGSELVVAGKLREQSPDVLLAQIRGQLHRENITYMMMSHVAEQEEMFRSPKYIFHSFIERLWAYLTIQQLLEQMVSALDAEKQALEARALSLSLSYSFVTPLTSMVITKPEGQEQSQVAEKPVEDGGCGPMRFGHSVGDRTSRKPGGGLKLLNGTPLFGPPGPPAAASPFHRMTSRLVLPELMSPLAPASAPSPTSGPGGASHDTDFRIKGTTPTALPFAPVQAPSVILPLPGQSVDRLCVDLRRPQELVNLLSDPDQGVEVTGHFETAKARFSWIEVTFENPQVQIHASPEHVVMTRNRRNSAYKWKETLYSVMPGLKVTMDKEGLLLLSRPDRVTIGLLFWDGPGKGLRLLLQNTDRFSSHVSGTLGQFYQDVLWGPLDTADDSKRTLKVQGRDYSATRELKLDYQESPPGKEISCWSVEL", "length": 875, "header": "tr|A0A3Q1LZ09-1|F1MMD7_BOVIN Computationally mapped isoform of Inter-alpha-trypsin inhibitor heavy chain 4 OS=Bos taurus OX=9913 GN=ITIH4 PE=3 SV=2 CANONICAL=F1MMD7-1" }, "locus": { "chromosome": "22", "start_pos": 48074433, "end_pos": 48060810, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067096.3", "url": "https://www.ensembl.org/id/ENSBTAT00000067096.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062534.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062534.2" } ] } }, { "isoform_ac": "A0A3Q1MA31-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MA31/entry", "sequence": { "sequence": "MKTPAPGRIHSIVLVLLSLAVLQTSKAQKVQNDIDIYSLTVDSKVSSRFAHTVITSRVVNKADAVREATFQMELPKKAFITNFSMVIDGVTYPGNIKEKAAAQEQYSAAVARGESAGLVRATGRKTEQFQVSVSVAPAAKVTFELVYEELLARHLGAYELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNKLAEALTTSQNKTKAHVRFKPTLSQQQKYPEKQDTVLDGSFIVRYDVDRPLSGGSIQIENGYFVHYFAPDSLSTIPKNVIFVIDKSGSMMGRKIKQTREALIKILDDLSPHDQFDLISFSSEATTWKPLLVPASTENVNEAKSYATGIQAQGGTNINDAMLMAVQLLEKANQEELLPEGSITLIILLTDGDPTVGETNPLNIQKNVRKAINGQHSLFCLGFGFDVSYAFLEKMALENGGLARRIYEDSDSALQLQDFYQEVANPLMTSVAFEYPSNAVESVTQDTFRVFFKGSELVVAGKLREQSPDVLLAQIRGQLHRENITYMMMSHVAEQEEMFRSPKYIFHSFIERLWAYLTIQQLLEQMVSALDAEKQALEARALSLSLSYSFVTPLTSMVITKPEGQEQSQVAEKPVEDGGGLKLLNGTPLFGPPGPPAAASPFHRMTSRLVLPELMSPLAPASAPSPTSGPGGASHDTDFRIKGTTPTALPFAPVQAPSVILPLPGQSVDRLCVDLRRPQELVNLLSDPDQGVEVTGHFETAKARFSWIEVTFENPQVQIHASPEHVVMTRNRRNSAYKWKETLYSVMPGLKVTMDKEGLLLLSRPDRVTIGLLFWDGPGKGLRLLLQNTDRFSSHVSGTLGQFYQDVLWGPLDTADDSKRTLKVQGRDYSATRELKLDYQESPPGKEISCWSVEL", "length": 890, "header": "tr|A0A3Q1MA31-1|F1MMD7_BOVIN Computationally mapped isoform of Inter-alpha-trypsin inhibitor heavy chain 4 OS=Bos taurus OX=9913 GN=ITIH4 PE=3 SV=2 CANONICAL=F1MMD7-1" }, "locus": { "chromosome": "22", "start_pos": 48074433, "end_pos": 48059612, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082142.3", "url": "https://www.ensembl.org/id/ENSBTAT00000082142.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070852.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070852.2" } ] } }, { "isoform_ac": "A0ABI0NXG7-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXG7/entry", "sequence": { "sequence": "MKTPAPGRIHSIVLVLLSLAVLQTSKAQKVQNDIDIYSLTVDSKVSSRFAHTVITSRVVNKADAVREATFQMELPKKAFITNFSMVIDGVTYPGNIKEKAAAQEQYSAAVARGESAGLVRATGRKTEQFQVSVSVAPAAKVTFELVYEELLARHLGAYELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNKLAEALTTSQNKTKAHVRFKPTLSQQQKYPEKQDTVLDGSFIVRYDVDRPLSGGSIQIENGYFVHYFAPDSLSTIPKNVIFVIDKSGSMMGRKIKQTREALIKILDDLSPHDQFDLISFSSEATTWKPLLVPASTENVNEAKSYATGIQAQGGTNINDAMLMAVQLLEKANQEELLPEGSITLIILLTDGDPTVGETNPLNIQKNVRKAINGQHSLFCLGFGFDVSYAFLEKMALENGGLARRIYEDSDSALQLQDFYQEVANPLMTSVAFEYPSNAVESVTQDTFRVFFKGSELVVAGKLREQSPDVLLAQIRGQLHRENITYMMMSHVAEQEEMFRSPKYIFHSFIERLWAYLTIQQLLEQMVSALDAEKQALEARALSLSLSYSFVTPLTSMVITKPEGQEQSQVAEKPVEDESRGSRVYLGGGLKLLNGTPLFGPPGPPAAASPFHRMTSRLVLPELMSPLAPASAPSPTSGPGGASHDTDFRIKGTTPTALPFAPVQAPSVILPLPGQSVDRLCVDLRRPQELVNLLSDPDQGVEVTGHFETAKARFSWIEVTFENPQVQIHASPEHVVMTRNRRNSAYKWKETLYSVMPGLKVTMDKEGLLLLSRPDRVTIGLLFWDGPGKGLRLLLQNTDRFSSHVSGTLGQFYQDVLWGPLDTADDSKRTLKVQGRDYSATRELKLDYQESPPGKEISCWSVEL", "length": 899, "header": "tr|A0ABI0NXG7-1|A0ABI0NXG7_BOVIN Computationally mapped isoform of Inter-alpha-trypsin inhibitor heavy chain 4 OS=Bos taurus OX=9913 GN=ITIH4 PE=3 SV=1 CANONICAL=F1MMD7-1" }, "locus": { "chromosome": "22", "start_pos": 48074433, "end_pos": 48059612, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000138819.1", "url": "https://www.ensembl.org/id/ENSBTAT00000138819.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104732.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104732.1" } ] } }, { "isoform_ac": "F1MMD7-1", "url": "https://www.uniprot.org/uniprotkb/F1MMD7/entry", "sequence": { "sequence": "MKTPAPGRIHSIVLVLLSLAVLQTSKAQKVQNDIDIYSLTVDSKVSSRFAHTVITSRVVNKADAVREATFQMELPKKAFITNFSMVIDGVTYPGNIKEKAAAQEQYSAAVARGESAGLVRATGRKTEQFQVSVSVAPAAKVTFELVYEELLARHLGAYELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNKLAEALTTSQNKTKAHVRFKPTLSQQQKYPEKQDTVLDGSFIVRYDVDRPLSGGSIQIENGYFVHYFAPDSLSTIPKNVIFVIDKSGSMMGRKIKQTREALIKILDDLSPHDQFDLISFSSEATTWKPLLVPASTENVNEAKSYATGIQAQGGTNINDAMLMAVQLLEKANQEELLPEGSITLIILLTDGDPTVGETNPLNIQKNVRKAINGQHSLFCLGFGFDVSYAFLEKMALENGGLARRIYEDSDSALQLQDFYQEVANPLMTSVAFEYPSNAVESVTQDTFRVFFKGSELVVAGKLREQSPDVLLAQIRGQLHRENITYMMMSHVAEQEEMFRSPKYIFHSFIERLWAYLTIQQLLEQMVSALDAEKQALEARALSLSLSYSFVTPLTSMVITKPEGQEQSQVAEKPVEDESRGSRVYLGPMRFGHSVGDRTSRKPGGGLKLLNGTPLFGPPGPPAAASPFHRMTSRLVLPELMSPLAPASAPSPTSGPGGASHDTDFRIKGTTPTALPFAPVQAPSVILPLPGQSVDRLCVDLRRPQELVNLLSDPDQGVEVTGHFETAKARFSWIEVTFENPQVQIHASPEHVVMTRNRRNSAYKWKETLYSVMPGLKVTMDKEGLLLLSRPDRVTIGLLFWDGPGKGLRLLLQNTDRFSSHVSGTLGQFYQDVLWGPLDTADDSKRTLKVQGRDYSATRELKLDYQESPPGKEISCWSVEL", "length": 916, "header": "tr|F1MMD7-1|F1MMD7_BOVIN Isoform 1 of Inter-alpha-trypsin inhibitor heavy chain 4 OS=Bos taurus OX=9913 GN=ITIH4 PE=3 SV=3 CANONICAL=F1MMD7-1" }, "locus": { "chromosome": "22", "start_pos": 48074433, "end_pos": 48059612, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010330.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010330.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010330.5", "url": "https://www.ensembl.org/id/ENSBTAP00000010330.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 688, "start_aa": "Thr", "end_pos": 688, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr688", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "F1MMD7", "url": "https://www.uniprot.org/uniprotkb/F1MMD7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MMD7", "url": "https://www.uniprot.org/uniprotkb/F1MMD7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MMD7", "url": "https://www.uniprot.org/uniprotkb/F1MMD7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MMD7", "url": "https://www.uniprot.org/uniprotkb/F1MMD7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "acute-phase response", "id": "GO:0006953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006953", "evidence": [ { "database": "UniProtKB", "id": "F1MMD7", "url": "https://www.uniprot.org/uniprotkb/F1MMD7" } ], "pmid": "" }, { "name": "hyaluronan metabolic process", "id": "GO:0030212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030212", "evidence": [ { "database": "UniProtKB", "id": "F1MMD7", "url": "https://www.uniprot.org/uniprotkb/F1MMD7" } ], "pmid": "" }, { "name": "response to cytokine", "id": "GO:0034097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034097", "evidence": [ { "database": "UniProtKB", "id": "F1MMD7", "url": "https://www.uniprot.org/uniprotkb/F1MMD7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 518, "end_pos": 520, "annotation": "n_glycosylation_sequon" }, { "start_pos": 646, "end_pos": 648, "annotation": "n_glycosylation_sequon" }, { "start_pos": 82, "end_pos": 84, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MMD7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 916, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MMD7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MMD7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MMD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD7" }, { "id": "PS51468", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51468" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VIT", "eco_id": "ECO_0000259", "start_pos": 20, "end_pos": 149, "start_aa": "Ala", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MMD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD7" }, { "id": "PS50234", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50234" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VWFA", "eco_id": "ECO_0000259", "start_pos": 275, "end_pos": 458, "start_aa": "Asn", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 688 ], "snv_sites": [], 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"monoisotopic_mass": 58623.0 }, "refseq": { "ac": "XP_059740696", "name": "UDP-N-acetylhexosamine pyrophosphorylase isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740696" }, "gene_names": [ { "name": "UAP1", "type": "recommended", "evidence": [ { "id": "F1MJP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ] }, { "name": "UAP1", "type": "synonym", "evidence": [ { "id": "XP_059740696", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740696" } ] } ], "protein_names": [ { "name": "UDP-N-acetylhexosamine pyrophosphorylase", "type": "recommended", "evidence": [ { "id": "F1MJP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJP7/entry#names_and_taxonomy" } ] }, { "name": "2.7.7.23", "type": "synonym", "evidence": [ { "id": "F1MJP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJP7/entry#names_and_taxonomy" } ] }, { "name": "2.7.7.83", "type": "synonym", 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"expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJP7", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "UAP1", "url": "https://www.uniprot.org/uniprotkb/F1MJP7", "locus": { "chromosome": "3", "start_pos": 6906313, "end_pos": 6938080, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010206", "url": "https://www.ensembl.org/id/ENSBTAG00000010206" } ] } } ], "crossref": [ { "id": "F1MJP7", "url": "https://alphafold.ebi.ac.uk/entry/F1MJP7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010206", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010206", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04193", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04193", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "535325", "url": "https://www.ncbi.nlm.nih.gov/gene/535325", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002618", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002618", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039741", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039741", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YFQVDNP", "url": "https://omabrowser.org/oma/group/YFQVDNP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1LZ31", "url": "https://www.orthodb.org/?gene=A0A3Q1LZ31", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MJP7", "url": "https://www.orthodb.org/?gene=F1MJP7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11952", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11952", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11952:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11952:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01704", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01704", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-446210", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446210", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059740696", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740696", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13509", "url": "https://www.rhea-db.org/rhea/13509", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "34363", "url": 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[ "Protein" ] } ], "sequence": { "sequence": "MNVNDLKLRLSKAGQEHLLDFWNELEEAQQVELYAELQAMNFQELNLFFQKAIEGFNHSSQPEKVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSHKTLFQIQAERILKLQQLAEKYHGSKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNIYEPQLQHHVAQKKIPFVDSQGQLVKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATHGKSEAITADVNHNLKDANDVPIQCEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI", "length": 522, "header": "tr|F1MJP7-1|F1MJP7_BOVIN Isoform 1 of UDP-N-acetylhexosamine pyrophosphorylase OS=Bos taurus OX=9913 GN=UAP1 PE=3 SV=1 CANONICAL=F1MJP7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1LZ31-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LZ31/entry", "sequence": { "sequence": "MNVNDLKLRLSKAGQEHLLDFWNELEEAQQVELYAELQAMNFQELNLFFQKAIEGFNHSSQPEKVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSHKTLFQIQAERILKLQQLAEKYHGSKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNIYEPQLQHHVAQKKIPFVDSQGQLVKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRLKDANDVPIQCEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI", "length": 505, "header": "tr|A0A3Q1LZ31-1|F1MJP7_BOVIN Computationally mapped isoform of UDP-N-acetylhexosamine pyrophosphorylase OS=Bos taurus OX=9913 GN=UAP1 PE=3 SV=1 CANONICAL=F1MJP7-1" }, "locus": { "chromosome": "3", "start_pos": 6933303, "end_pos": 6906806, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076081.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076081.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066071.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066071.1" } ] } }, { "isoform_ac": "A0AAA9SUJ9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUJ9/entry", "sequence": { "sequence": "MNVNDLKLRLSKAGQEHLLDFWNELEEAQQVELYAELQAMNFQELNLFFQKAIEGFNHSSQPEKVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSHKTLFQIQAERILKLQQLAEKYHGSKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNIYEPQLQHHVAQKKIPFVDSQGQLVKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATHGKSEAITADVNHK", "length": 470, "header": "tr|A0AAA9SUJ9-1|F1MJP7_BOVIN Computationally mapped isoform of UDP-N-acetylhexosamine pyrophosphorylase OS=Bos taurus OX=9913 GN=UAP1 PE=3 SV=1 CANONICAL=F1MJP7-1" }, "locus": { "chromosome": "3", "start_pos": 6933303, "end_pos": 6911584, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000105861.1", "url": "https://www.ensembl.org/id/ENSBTAT00000105861.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087825.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087825.1" } ] } }, { "isoform_ac": "F1MJP7-1", "url": "https://www.uniprot.org/uniprotkb/F1MJP7/entry", "sequence": { "sequence": "MNVNDLKLRLSKAGQEHLLDFWNELEEAQQVELYAELQAMNFQELNLFFQKAIEGFNHSSQPEKVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSHKTLFQIQAERILKLQQLAEKYHGSKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNIYEPQLQHHVAQKKIPFVDSQGQLVKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATHGKSEAITADVNHNLKDANDVPIQCEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI", "length": 522, "header": "tr|F1MJP7-1|F1MJP7_BOVIN Isoform 1 of UDP-N-acetylhexosamine pyrophosphorylase OS=Bos taurus OX=9913 GN=UAP1 PE=3 SV=1 CANONICAL=F1MJP7-1" }, "locus": { "chromosome": "3", "start_pos": 6933303, "end_pos": 6906806, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013466.5", "url": "https://www.ensembl.org/id/ENSBTAT00000013466.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013466.3", "url": "https://www.ensembl.org/id/ENSBTAP00000013466.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-446210", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446210", "resource": "Reactome", "description": "Synthesis of UDP-N-acetyl-glucosamine" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0R4INK2-1", "protein_name": "UDP-N-acetylhexosamine pyrophosphorylase", "gene_name": "uap1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDIHKLAERLAKAGQSHVIQFWDQLSPEEQGEMSLDLESMNFLEINNFFKSAMKTSGQSSQEKVDTRMEPVPRDVLGSVTRDRECLKEWEKEGLRCIAENKVAVLLLAGGQGTRLGVSFPKGMYDVGLPSHKTLFQIQAERIRKLEQLAEKQHSRKCCIPWYIMTSGRTMDMTKDFFIQHKYFGLKEENVVFFQQGMLPAMDFNGKIILEGKCKLAMAPDGNGGLYRALGTQNIVKDMETRGISYIHVYCVDNILVKVADPAFIGFCTLKGADCGAKVVEKTNPTEAVGVVCKVDGRYQVVEYSEITLATAEKRSTDGRLMFNAGNIANHFFTLTFLREIVRTHEPQLQHHVAQKKIPYVNTEGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQDGKDNPTTARHALMSLHHRWILNAGGHFVDENGTHIPAIPRAGPAGTVTPEVSQNLKDGTDLPIKCEISPLVSYGGEGLEHLVNEKVFQPTLIINESGVHELVKNGL", "length": 518 }, "evidence": [ { "id": "F1MJP7", "url": "https://omabrowser.org/oma/group/F1MJP7/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A480KKH4-1", "protein_name": "UDP-N-acetylhexosamine pyrophosphorylase", "gene_name": "UAP1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MNVNDLKLRLSKAGQEHLLHFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEDFNHSSQQEKVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSHKTLFQIQAERILKLQQLAEKYHGNKCIIPWYIMTSGRTMDSTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNIYEPQLQHHVAQKKIPYVDSLGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQCEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI", "length": 522 }, "evidence": [ { "id": "F1MJP7", "url": "https://omabrowser.org/oma/group/F1MJP7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D3ZF39-1", "protein_name": "UDP-N-acetylhexosamine pyrophosphorylase", "gene_name": "Uap1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNVNDLRQRLSAAGQQHLLQFWSELSEAQQGELYMELQAMNFEELNSFFQKAVGEFDRSSHQEKVDARMEPVPRQVLGSATRDQDQLQAWESEGLSQISQNKVAVLLLAGGQGTRLGVTYPKGMYDVGLPSHKTLFQIQAERILKLQQLAEKQYGNKCTIPWYIMTSGRTMESTKEFFTKHKFFGLKKENVVFFQQGMLPAMSFDGKVILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLKDVVNVYEPQLQHHVAQKKIPYVDSQGHLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQCEISPLISYAGEGLEGYVADKDFHAPLIIDENGVHELVKNGI", "length": 522 }, "evidence": [ { "id": "F1MJP7", "url": "https://omabrowser.org/oma/group/F1MJP7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P43123-1", "protein_name": "UDP-N-acetylglucosamine pyrophosphorylase", "gene_name": "QRI1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTDTKQLFIEAGQSQLFHNWESLSRKDQEELLSNLEQISSKRSPAKLLEDCQNAIKFSLANSSKDTGVEISPLPPTSYESLIGNSKKENEYWRLGLEAIGKGEVAVILMAGGQGTRLGSSQPKGCYDIGLPSKKSLFQIQAEKLIRLQDMVKDKKVEIPWYIMTSGPTRAATEAYFQEHNYFGLNKEQITFFNQGTLPAFDLTGKHFLMKDPVNLSQSPDGNGGLYRAIKENKLNEDFDRRGIKHVYMYCVDNVLSKIADPVFIGFAIKHGFELATKAVRKRDAHESVGLIATKNEKPCVIEYSEISNELAEAKDKDGLLKLRAGNIVNHYYLVDLLKRDLDQWCENMPYHIAKKKIPAYDSVTGKYTKPTEPNGIKLEQFIFDVFDTVPLNKFGCLEVDRCKEFSPLKNGPGSKNDNPETSRLAYLKLGTSWLEDAGAIVKDGVLVEVSSKLSYAGENLSQFKGKVFDRSGIVLEK", "length": 477 }, "evidence": [ { "id": "F1MJP7", "url": "https://omabrowser.org/oma/group/F1MJP7/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q16222-1", "protein_name": "UDP-N-acetylhexosamine pyrophosphorylase", "gene_name": "UAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSSHQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPYVDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQCEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI", "length": 522 }, "evidence": [ { "id": "F1MJP7", "url": "https://omabrowser.org/oma/group/F1MJP7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q54GN5-1", "protein_name": "Probable UDP-N-acetylglucosamine pyrophosphorylase", "gene_name": "uap1", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MDTTNFEDIRNEWIEQGQGHVFNWFDKLSNEEKLNFENDIRKINVKEVNKDYKNVLLNKDEQKIMKYEHFENVMTLNKIKEQDKKKWEDIGYELISKGEVAVLLLAGGQATRLGTTFPKGFYDVGLPSKKSLFQLQAERIYRLQQLVSERYNGSYDQDSKPIQWYIMTSEATHSETIKFFENKNYFGLKKSAFFFFSQAMIPCITPEDGKIISESGSKLSLSPNGNGGLFKALSTSGAIDDMRKKGIKYVTQYCVDNILINMADPVFVGYMHDQSADCGAKVVSKSDPKEPVGVMALNGDGKPFVLEYSEIDEQSKFKKDQNGQLVFNYAHICINAFSFDFLDRIAKNHLDHLKYHVAFKKIPSAHPISGERQSPSSPNGWKLEKFIFDVFPFSKKMVCLEIERSKEFSPLKNCGGMNLPDSPETCLRDISNLHKSFIENSGGKIDSSNSTICEVSPLVSLNGENLKNFVNDKTFILPIEINQNLNN", "length": 487 }, "evidence": [ { "id": "F1MJP7", "url": "https://omabrowser.org/oma/group/F1MJP7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q940S3-1", "protein_name": "UDP-N-acetylglucosamine diphosphorylase 1", "gene_name": "GLCNAC1PUT1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MIEPSMERENGALTAATTTTTAVTSPPPMASSPRQALVERLKDYGQEDIFSLWDELSPDEKDFLVRDIENLDLPRIDRIIRCSLHSQGLPVAAIEPVPENWVSTVDGRTMEDREKWWKMGLKTIYEGKLGVVLLSGGQGTRLGSSDPKGCFNIGLPSGKSLFQIQAERILCVQRLAAQVVSEGPIRPVTIHWYIMTSPFTDEATRKYFSSHKYFGLEPDQISFFQQGTLPCVTKDGKFIMETPFSLAKAPDGNGGVYAALKCSRLLEDMASRGIKYVDCYGVDNVLVRVADPTFLGYFIDKGAASAAKVVRKAYPQEQVGVFVRRGKGGPLTVVEYSELDQSMASAINQRTGRLQYCWSNVCLHMFTLDFLNQVATGLEKDSVYHLAEKKIPSMNGYTMGLKLEQFIFDSFPYAPSTALFEVLREEEFAPVKNVNGSNFDTPESARLLVLRLHTRWVIAAGGFLTHSVPLYATGVEVSPLCSYAGENLEAICRGRTFHAPCEISL", "length": 505 }, "evidence": [ { "id": "F1MJP7", "url": "https://omabrowser.org/oma/group/F1MJP7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9Y0Z0-1", "protein_name": "UDP-N-acetylglucosamine diphosphorylase", "gene_name": "mmy", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGRSNFSSHHQQTHVRRHRNAGGATSKSPNAAKTSPTMTDYLSLHSRLAQVGQEHLLKFWPELTNDERIDLVRDIEELNLDEIKLYFDRATVSMNENGIKLDDRLQPLPEGKLISIARAPLEKLDAYRDEGLLQISNGHVAVLLMAGGQGTRLGFDHPKGMYDVGLQSRKTLFRIQAERILKLEELAQEANGKRGHITWYIMTSEHTVQPTYDYFVANNFFGLKAENVLLFEQGSLPCFEYDGRIILDEKHRVARAPDGNGGIYRAMKRQGILDDMQKRGVLYLHAHSVDNILIKVADPVFIGYCVQEKADCAAKVVEKAAPNEAVGVVAIVDGKYQVVEYSEISAKTAEMRNSDGRLTFSAGNICNHFFSSNFLQKIGSTYEQELKLHVAKKKIPFVDNAGKRLTPDKPNGIKIEKFVFDVFEFAQKFVAMEVPRDEEFSALKNSDAAGKDCPSTARSDLHRLHKKYIEGAGGIVHGEVCEISPFVTYAGENLASHVEGKSFTSPVYLRDSRDPLHGHL", "length": 520 }, "evidence": [ { "id": "F1MJP7", "url": "https://omabrowser.org/oma/group/F1MJP7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MJP7", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "F1MJP7", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ], "pmid": "" }, { "name": "UDP-N-acetylglucosamine biosynthetic process", "id": "GO:0006048", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006048", "evidence": [ { "database": "UniProtKB", "id": "F1MJP7", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ], "pmid": "" }, { "name": "positive regulation of type I interferon production", "id": "GO:0032481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032481", "evidence": [ { "database": "UniProtKB", "id": "F1MJP7", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ], "pmid": "" }, { "name": "antiviral innate immune response", "id": "GO:0140374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140374", "evidence": [ { "database": "UniProtKB", "id": "F1MJP7", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "UDP-N-acetylglucosamine diphosphorylase activity", "id": "GO:0003977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003977", "evidence": [ { "database": "UniProtKB", "id": "F1MJP7", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ], "pmid": "" }, { "name": "UDP-N-acetylgalactosamine diphosphorylase activity", "id": "GO:0052630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052630", "evidence": [ { "database": "UniProtKB", "id": "F1MJP7", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ], "pmid": "" }, { "name": "uridylyltransferase activity", "id": "GO:0070569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070569", "evidence": [ { "database": "UniProtKB", "id": "F1MJP7", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1MJP7", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ], "pmid": "" }, { "name": "protein serine pyrophosphorylase activity", "id": "GO:0141090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141090", "evidence": [ { "database": "UniProtKB", "id": "F1MJP7", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 444, "end_pos": 446, "annotation": "n_glycosylation_sequon" }, { "start_pos": 57, "end_pos": 59, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13509", "name": "", "equation": "N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJP7-1" ], "evidence": [ { "id": "13509", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13509" } ] }, { "id": "34363", "name": "", "equation": "N-acetyl-alpha-D-galactosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-galactosamine + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJP7-1" ], "evidence": [ { "id": "34363", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/34363" } ] }, { "id": "64104", "name": "", "equation": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] = O-diphospho-L-seryl-[protein] + 1D-myo-inositol hexakisphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJP7-1" ], "evidence": [ { "id": "64104", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/64104" } ] }, { "id": "R-BTA-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJP7-1" ], "evidence": [ { "id": "R-BTA-446204", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-446204" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1MJP7", "gene_name": "UAP1", "activity": [ { "ec_number": "2.7.7.23", "activity": "N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate.", "evidence": [ { "id": "F1MJP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ] }, { "ec_number": "2.7.7.83", "activity": "N-acetyl-alpha-D-galactosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-galactosamine + diphosphate.", "evidence": [ { "id": "F1MJP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ] }, { "ec_number": "2.7.7.83", "activity": "", "evidence": [ { "id": "F1MJP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ] }, { "ec_number": "2.7.7.23", "activity": "", "evidence": [ { "id": "F1MJP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJP7" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJP7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 522, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJP7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJP7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.7.23", "ec_name": "N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate.", "evidence": [ { "id": "2.7.7.23", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.23" }, { "id": "2.7.7.23", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.7.23" } ] }, { "ec_number": "2.7.7.83", "ec_name": "N-acetyl-alpha-D-galactosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-galactosamine + diphosphate.", "evidence": [ { "id": "2.7.7.83", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.83" }, { "id": "2.7.7.83", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.7.83" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 444, "end_pos": 446 }, { "start_pos": 57, "end_pos": 59 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"uniprot_canonical_ac": "F1MN63-1", "uniprot_ac": "F1MN63", "uniprot_id": "F1MN63_BOVIN", "mass": { "chemical_mass": 180523.0, "monoisotopic_mass": 180523.0 }, "refseq": { "ac": "XP_005218248", "name": "GATOR1 complex protein DEPDC5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218248" }, "gene_names": [ { "name": "DEPDC5", "type": "recommended", "evidence": [ { "id": "F1MN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN63" } ] }, { "name": "DEPDC5", "type": "synonym", "evidence": [ { "id": "XP_005218248", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218248" } ] } ], "protein_names": [ { "name": "GATOR1 complex protein DEPDC5", "type": "recommended", "evidence": [ { "id": "F1MN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN63/entry#names_and_taxonomy" } ] }, { "name": "DEP domain-containing protein 5", "type": "synonym", "evidence": [ { "id": "F1MN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN63/entry#names_and_taxonomy" } ] }, { "name": "GATOR1 complex protein DEPDC5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005218248", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218248" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MN63", "url": "https://www.uniprot.org/uniprotkb/F1MN63" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DEPDC5", "url": "https://www.uniprot.org/uniprotkb/F1MN63", "locus": { "chromosome": "17", "start_pos": 70478549, "end_pos": 70405028, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001295", "url": "https://www.ensembl.org/id/ENSBTAG00000001295" } ] } } ], "crossref": [ { "id": "ENSBTAG00000001295", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001295", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04449", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04449", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521542", "url": "https://www.ncbi.nlm.nih.gov/gene/521542", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027244", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027244", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045838", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045838", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048255", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048255", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521542", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521542", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RTWHFKR", "url": "https://omabrowser.org/oma/group/RTWHFKR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MEL7", "url": "https://www.orthodb.org/?gene=A0A3Q1MEL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MN63", "url": "https://www.orthodb.org/?gene=F1MN63", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13179", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13179", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13179:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13179:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00610", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00610", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12257", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12257", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19418", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19418", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23013", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23013", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9639288", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9639288", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005218248", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218248", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0Z4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Z4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M0Z4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0Z4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEL7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MEL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RT40", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT40", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RT40-1", "url": 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"MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSLDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNATSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPHDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPTCEKAKNGRDTSLGTPKESENALPIQVDYDAYDAQVFRLPGPSRAQRLSTCRSVRERESHSRKSASSCDVSSSPSLPGRTLPTEEVRSQASDDSSLGRSANILVIPHPHLHQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDLTHSSAELLELAYHEAAGRHSTSRQPGDGTSFLSFAGTEELSVSLLRGSGADVSPRTQNKDSPEDSVSTSPDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEEGVQMTAQQVFEEFICQRLMQGYQIIVQPRAQKPSPAGPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPNLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFIRFVEGLNRIRRRHRSDRMMRKGATMKGLQMAGPIPTHSLESAGPPVGKKGTSALSALLEMEASQKCLGEQQAAAHGVKSSAPPAESGGVAMTPTYVDSPRKVSLDQTAAPVLDSSSLGVSTGQSVDRGNSQTFGNLQSLGEQGFPSANSSDSGAQQLVASSLTSSSTLVEILEAMKHPSTGVQLLPEQKGLSPSCFISAEVVHWLVNNVEGVQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVMDRDPERVAVQQPTTWHTTAVDDFASFQRKWFEVAFVAEELLHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDGFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQPRRRRNSTSSASQTLFCEERVGYNWAYNTMLTKTWRSSATGDERFADRLLKDFTDFCGNRDSRLVAFWASCLEKMHASAP", "length": 1515, "header": "tr|A0A3Q1M0Z4-1|F1MN63_BOVIN Computationally mapped isoform of GATOR1 complex protein DEPDC5 OS=Bos taurus OX=9913 GN=DEPDC5 PE=3 SV=2 CANONICAL=F1MN63-1" }, "locus": { "chromosome": "17", "start_pos": 70477545, "end_pos": 70406010, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076690.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076690.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063348.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063348.2" } ] } }, { "isoform_ac": "A0A3Q1MEL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEL7/entry", "sequence": { "sequence": "MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSLDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNATSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPHDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPTCEKAKNGRDTSLGTPKESENALPIQVDYDAYDAQVFRLPGPSRAQRLSTCRSVRERESHSRKSASSCDVSSSPSLPGRTLPTEEVRSQASDDSSLGRSANILVIPHPHLHQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDLTHSSAELLELAYHEAAGRHSTSRQPGDGTSFLSFAGTEELSVSLLRGSGADVSPRTQNKDSPEDSVSTSPDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEEGVQMTAQQVFEEFICQRLMQGYQIIVQPRAQKPSPAGPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFIRFVEGLNRIRRRHRSDRMMRKGATMKGLQMAGPIPTHSLESAGPPVGKKGTSALSALLEMEASQKCLGEQQAAAHGVKSSAPPAESGGVAMTPTYVDSPRKVSLDQTAAPVLDSSSLGVSTGQSVDRGNSQTFGNLQSLGEQGFPSANSSDSGAQQLVASSLTSSSTLVEILEAMKHPSTGVQLLPEQKGLSPSCFISAEVVHWLVNNVEGVQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVMDRDPERVAVQQPTTWHTTAVDDFASFQRKWFEVAFVAEELLHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDGFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTVFLQLPYSKRKFSGQPRRRRNSTSSASQTLFCEERVGYNWAYNTMLTKTWRSSATGDERFADRLLKDFTDFCGNRDSRLVAFWASCLEKMHASAP", "length": 1569, "header": "tr|A0A3Q1MEL7-1|F1MN63_BOVIN Computationally mapped isoform of GATOR1 complex protein DEPDC5 OS=Bos taurus OX=9913 GN=DEPDC5 PE=3 SV=3 CANONICAL=F1MN63-1" }, "locus": { "chromosome": "17", "start_pos": 70477545, "end_pos": 70406010, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068154.3", "url": "https://www.ensembl.org/id/ENSBTAT00000068154.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068942.3", "url": "https://www.ensembl.org/id/ENSBTAP00000068942.3" } ] } }, { "isoform_ac": "A0AAA9RT40-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT40/entry", "sequence": { "sequence": "MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSLDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNATSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPHDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPTCEKAKNGRDTSLGTPKESENALPIQVDYDAYDAQVFRLPGPSRAQRLSTCRSVRERESHSRKSASSCDVSSSPSLPGRTLPTEEVRSQASDDSSLGRSANILVIPHPHLHQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVDVSPRTQNKDSPEDSVSTSPDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEEGVQMTAQQVFEEFICQRLMQGYQIIVQPRAQKPSPAGPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFIRFVEGLNRIRRRHRSDRMMRKGATMKGLQMAGPIPTHSLESAGPPVGKKGTSALSALLEMEASQKCLGEQQAAAHGVKSSAPPAESGGVAMTPTYVDSPRKDGAFFMEFVRSPRTASSAFYPQVSLDQTAAPVLDSSSLGVSTGQSVDRGNSQTFGNLQSLGEQGFPSANSSDSGAQQLVASSLTSSSTLVEILEAMKHPSTGVQLLPEQKGLSPSCFISAEVVHWLVNNVEGVQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVMDRDPERVAVQQPTTWHTTAVDDFASFQRKWFEVAFVAEELLHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDGFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQPRRRRNSTSSASQTLFCEERVGYNWAYNTMLTKTWRSSATGDERFADRLLKDFTDFCGNRDSRLVAFWASCLEKMHASAP", "length": 1524, "header": "tr|A0AAA9RT40-1|F1MN63_BOVIN Computationally mapped isoform of GATOR1 complex protein DEPDC5 OS=Bos taurus OX=9913 GN=DEPDC5 PE=3 SV=1 CANONICAL=F1MN63-1" }, "locus": { "chromosome": "17", "start_pos": 70477545, "end_pos": 70406010, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114202.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114202.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075976.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075976.1" } ] } }, { "isoform_ac": "A0AAA9SSI6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSI6/entry", "sequence": { "sequence": "MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSLDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNATSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPHDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPTCEKAKNGRDTSLGTPKESENALPIQVDYDAYDAQVFRLPGPSRAQRLSTCRSVRERESHSRKSASSCDVSSSPSLPGRTLPTEEVRSQASDDSSLGRSANILVIPHPHLHQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDLTHSSAELLELAYHEAAGRHSTSRQPGDGTSFLSFAGTEELSVSLLRGSGADVSPRTQNKDSPEDSVSTSPDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEEGVQMTAQQVFEEFICQRLMQGYQIIVQPRAQKPSPAGPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFIRFVEGLNRIRRRHRSDRMMRKGATMKGLQMAGPIPTHSLESAGPPVGKKGTSALSALLEMEASQKCLGEQQAAAHGVKSSAPPAESGGVAMTPTYVDSPRKDGAFFMEFVRSPRTASSAFYPQVSLDQTAAPVLDSSSLGVSTGQSVDRGNSQTFGNLQSLGEQGFPSANSSDSGAQQLVASSLTSSSTLVEILEAMKHPSTGVQLLPEQKGLSPSCFISAEVVHWLVNNVEGVQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVMDRDPERVAVQQPTTWHTTAVDDFASFQRKWFEVAFVAEELLHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDGFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQPRRRRNSTSSASQTLFCEERVGYNWAYNTMLTKTWRSSATGDERFADRLLKDFTDFCGNRDSRLVAFWASCLEKMHASAP", "length": 1574, "header": "tr|A0AAA9SSI6-1|F1MN63_BOVIN Computationally mapped isoform of GATOR1 complex protein DEPDC5 OS=Bos taurus OX=9913 GN=DEPDC5 PE=3 SV=1 CANONICAL=F1MN63-1" }, "locus": { "chromosome": "17", "start_pos": 70477545, "end_pos": 70406010, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128748.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128748.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085984.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085984.1" } ] } }, { "isoform_ac": "A0AAA9TN02-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TN02/entry", "sequence": { "sequence": "MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSLDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNATSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPHDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPTCEKAKNGRDTSLGTPKESENALPIQVDYDAYDAQVFRLPGPSRAQRLSTCRSVRERESHSRKSASSCDVSSSPSLPGRTLPTEEVRSQASDDSSLGRSANILVIPHPHLHQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDLTHSSAELLELAYHEAAGRHSTSRQPGDGTSFLSFAGTEELSVSLLRGSGADVSPRTQNKDSPEDSVSTSPDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEEGVQMTAQQVFEEFICQRLMQGYQIIVQPRAQKPSPAGPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFIRFVEGLNRIRRRHRSDRMMRKGATMKGLQMAGPIPTHSLESAGPPVGKKGTSALSALLEMEASQKCLGEQQAAAHGVKSSAPPAESGGVAMTPTYVDSPRKDGAFFMEFVRSPRTASSAFYPQVSLDQTAAPVLDSSSLGVSTGQSVDRGNSQTFGNLQSLGEQGFPSANSSDSGAQQLVASSLTSSSTLVEILEAMKHPSTGVQLLPEQKGLSPSCFISAEVVHWLVNNVEGVQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVMDRDPERVAVQQPTTWHTTAVDDFASFQRKWFEVAFVAEELLHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDGLGLFKISILRPLSTSQPRTSPSTSMSQGQCSCSCPTPSASSQGSRGGAATPPAPPARPCSARSAWATTGPTTPCSPRPGAPAPPATRGSPTGC", "length": 1551, "header": "tr|A0AAA9TN02-1|F1MN63_BOVIN Computationally mapped isoform of GATOR1 complex protein DEPDC5 OS=Bos taurus OX=9913 GN=DEPDC5 PE=3 SV=2 CANONICAL=F1MN63-1" }, "locus": { "chromosome": "17", "start_pos": 70477453, "end_pos": 70406010, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108073.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108073.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098634.2", "url": "https://www.ensembl.org/id/ENSBTAP00000098634.2" } ] } }, { "isoform_ac": "F1MN63-1", "url": "https://www.uniprot.org/uniprotkb/F1MN63/entry", "sequence": { "sequence": "MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSLDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNATSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPHDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPTCEKAKNGRDTSLGTPKESENALPIQVDYDAYDAQVFRLPGPSRAQRLSTCRSVRERESHSRKSASSCDVSSSPSLPGRTLPTEEVRSQASDDSSLGRSANILVIPHPHLHQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDLTHSSAELLELAYHEAAGRHSTSRQPGDGTSFLSFAGTEELSVSLLRGSGADVSPRTQNKDSPEDSVSTSPDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEEGVQMTAQQVFEEFICQRLMQGYQIIVQPRAQKPSPAGPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFIRFVEGLNRIRRRHRSDRMMRKGATMKGLQMAGPIPTHSLESAGPPVGKKGTSALSALLEMEASQKCLGEQQAAAHGVKSSAPPAESGGVAMTPTYVDSPRKDGAFFMEFVRSPRTASSAFYPQVSLDQTAAPVLDSSSLGVSTGQSVDRGNSQTFGNLQSLGEQGFPSANSSDSGAQQLVASSLTSSSTLVEILEAMKHPSTGVQLLPEQKGLSPSCFISAEVVHWLVNNVEGVQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVMDRDPERVAVQQPTTWHTTAVDDFASFQRKWFEVAFVAEELLHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDGFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQPRRRRNSTSSASQTLFCEERVGYNWAYNTMLTKTWRSSATGDERFADRLLKDFTDFCGNRDSRLVAFWASCLEKMHASAP", "length": 1602, "header": "tr|F1MN63-1|F1MN63_BOVIN Isoform 1 of GATOR1 complex protein DEPDC5 OS=Bos taurus OX=9913 GN=DEPDC5 PE=3 SV=4 CANONICAL=F1MN63-1" }, "locus": { "chromosome": "17", "start_pos": 70477545, "end_pos": 70406010, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001707.8", "url": "https://www.ensembl.org/id/ENSBTAT00000001707.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001707.7", "url": "https://www.ensembl.org/id/ENSBTAP00000001707.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:521542", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521542", "resource": "KEGG Pathway" }, { "id": "R-BTA-9639288", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9639288", "resource": "Reactome", "description": "Amino acids regulate mTORC1" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D0ZFE4-1", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "DEPDC5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MRTTKVYKLVIHKKGFGGSDDELVMNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTYYDAKSIDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSHLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGTPKESENTLPIQVDYDAYDAQVFRLPGPSRAQRLVTCRSVRERESHSRKSASSCDVSSSPSLPGRALPTEEVRSQASDDSSLGRSANILMIPHPHLHQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLELAYHEAAGRHSASRQPGDGMSFLNFSGTEELSVSLLSNSGSGMNPRTQNRDSLEDSVSTSPDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEEGVQMTAQQVFEEFICQRLMQGYQIIVQPKAQKASPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQTHYTYSLCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEEEWQLLDGFIRFVEGLNRIRRRHRSDRVMRKGTSMKGLQMAGPIPTHSLESTGPPVGKKGTSALSALLEMEATQKCLGEQQAAVHGSKSSAQPAESSGVAMTPTYVDSPRKDGAFFMEFVRSPRTASSAFYPQVSLDQTAAPVLDGTSLGVSAGQSIDRGNSQTFGNSQSSGEQGFPSANSSDSSSQQLVASSLTSSSTLVEILEAMKHPTTGVQLLPEQKGLSPCCFISAEVVHWLVNNVEGVQTQAMAVDIMQKMLEEQLITHASGEVWRTFIYGFYFYKIVMDREPERVAMQQPTTWHTTAMDDFASFQRKWFEVAFVAEELLHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDNFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQPRRRRNSTSSTSQSLFCEERVGYNWAYNTMLTKTWRSSATGDDRFADRLLKDFTDFCINRDNRLVAFWTSCLEKMHASAP", "length": 1593 }, "evidence": [ { "id": "F1MN63", "url": "https://omabrowser.org/oma/group/F1MN63/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I5YBC5-1", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "Depdc5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEETRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSIDEFPEVNRASIQQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAGGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSVPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKSATEKTKNGRDTSLGAPKESENTLPIQVDYDAYDAQVFRLPGPSRAQRLATCRSVREQENHNRKSASSCDVSSSPSLPSRALPTEEVRSQASDDSSLGKSTNILMIPNPHLHQYEVSSSLGYTSTRDVLENMIEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSRQRDPTHSSAELLELAYHEAAGRHSTSRQPGDSMSLNFSGTEELSVSLLSNSGTGMNPRNQNKDSLEDGVSTSPDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADMDRRDEEGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPSTTVPPPLSSSPLYSRGLVSRNRPEEEGQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFCHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEVHCDIYGDKPRADEDEWQLLDGFIRFVEGLNRIRRRHRSDRMIRKGTAMKGLQMTGPISAHSLESTGPPVGKKGTSALSALLEMEASQKSLGEQQTSVHGKSSTQPAENSSVAMTPTYVDSPRKDGAFFMEFVRSPRTASSAFYPQASVDQTAPLVLDSTSLGVSTCQSVDRGNNQTFGNSQNIEQAFPSTGSGDGSSQQHIASSLTSSSTLVEILEAMKHPSTGVQLLSEQKGLSPCCFISAEVVHWLMNNVEGVQTQAMGIDIMQKMLEEQLIAHASGEAWRTFVYGFYFYKIVTDREPERVAMQQPSAPWHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTATVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNLGCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFWTNCLEKMHASAP", "length": 1600 }, "evidence": [ { "id": "F1MN63", "url": "https://omabrowser.org/oma/group/F1MN63/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8M9QKY4-1", "protein_name": "GATOR1 complex protein DEPDC5 isoform X1", "gene_name": "depdc5", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTVTMKANKSYKLVVHKKGFGGSDDELMMNPKVFPQVKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVAQAFKLRAYQDVIINIVDPKEVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYVTQKVEFAGIRAQASELWVKGEKVTCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLSDLFAKWKEKNCSHEVTVVLFSRTFYSAKTLEEFPESQRASVRQDHEGRYYEDFYRVVAQNERRDEWMSLLVTIKKLFIQYPVLVRLKGADGFPCGHNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRTVHGDSRIGDDYNLPHWINHSFYTSKSQNSCSCFTPRIKLAGKKVHAEKAKNSKEHSLGAPKDAENSLPIQVDYDAYDSQVFRLPGPSRAQRSTNFSSSHINSTDSNRSSRERESVSRKSWGSADVGSSPPNRHTGPDEQRSLASDDSLGHMSNILLIPRPAQGQYEVSSSLGYTSCTRELLEKMVESQRDSSAPGRFTVGSAESTLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEPIQIHHQTRQNMAELQGSEQRDPARTSAELLELAYHEATGSKRTASRHAGENGLYISGVPDNISGSPASSSSTGTPVNRGSFEDYSGSLDPILLLSAPPTVPSFCCTVGVDWKSLTTPACLPLTTDYFPDRQTLQNDYTEGCYDLLPHTDLERRDDETPVMTAHQVFEEFICQRLMQGYQIIVQPNRKPQPAIAPPLSSSPLYSRGLVSRRKPEEEESLYWLSMGRTFHKVCLKDKIITVTRYLPKYPYESTQIQYSYNLCPPHADAHFMPFWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIDSLKFWRTRFLLLPAGGARRVADGEGHWDVYGEGAGAGRDGLAGTGDWTLLDGFIRFLEGLNRIRRRHRSDRMIRKGATIKGLQVTGALTSYTPEPIAPPLGKKGTSALSALLELEQTQKTFEEQQLAAQHGGKPCGPFSEAANVALTTTFVDSPRKDAAFILDFIRSPRSSYICHSQLPAEQVPANPIEGGLSDKISNQPGERTSAASQATGDPTPGASLETGGQSGSSGLSLSSSSTLMEILEAIKHPTTGVQLLPEQRGLPPNCFVSAEVVHWLVSTVENVATQGIAVEIMQKMLEEGLITHASGDAMRTFVYGFYFYRIVDKDNEKAPLTQLPPAGANVWSAAALEDFALFQRKWFEVAFVMEERRPCDLPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQKTVTLDVDVNNRSDRTEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKAASCGFLLVPVLEVPFALSSYLYGDPLRAQLFIPLNIQCLLKEGSDNLFEGFEPETYWDRMQLFQEAILTRFGFVQDKFSASAFNFPSENKPQYIHVTGTVFLQLPYSKRKYSSGQRRRRNSTTSTNQSLFGSEERVGYNWAYNTMLTKAWRTGVLGDEKLADRLLRDFTDFCANKDNRLVTFWESCVEKMNASAP", "length": 1614 }, "evidence": [ { "id": "F1MN63", "url": "https://omabrowser.org/oma/group/F1MN63/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V1A160-1", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "DEPDC5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRTNKVYKLVIHKKGFGGSDDELVVNPKVFLQIKLGDVVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVAQVFRLRPYQDVHVNVVDPKEVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYVTQKVEFAGIRAQAGELWVKSEKVTCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYEAKCIDEFPETHRASIRQDHEGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPPGFNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRCGPGDSRLGDDYNIPHWINHSFYTSKSQLQCNSFTPRIKLAGRKPLTEKTKNSRDASLGAPKDAENALPIQVDYDGYDAQVFRLPGPSRAQRCTTFSRSVRERESRTRKSSSSYDVSCSPSLQSRTLPPEEVRSQASDDSSLGKISNILMIPRPHLHQYEVSSSLGYTSTRDVLENMLESQQRDSSAPGRFHVGSAESMLHIRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAEMQDSGQQDLTHSSAELLELAYHEAAGRHSTSRHPGDGASFLTFSGTEEYSNGLAGSNGAGMNLKTQNKDSSEDAVSNSPDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQSLQNDYTEGCYDLLPEADMDRRDEEGVQMTAQQVFEEFICQRLMQGYQIIVQPKPQKPATTVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKIITVTRYLPKYPYESAQINYTYSLCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACISATKRIMEGEVHCDVYGDKPRSDEEEWQLLDGFIRFVEGLNRIRRRHRSDRMIRKGSAMKGLQIAGPLPTHSLEQSGPPIGKKGTSALSALLEMEANQKSLGEQQAAMLSGKSSGQPSESGSIAITPTYMDSPRKDGAFFMDFVRSPRSASTFFSQVSIDQSVPGTADATTLINTGQSAERGSTQSLGSSQSTTDQGYVTAGAAEGSSQQCSVSSLTSSSTLMEILEAMKHPTTGIQLLSEQKGLSPSCFISAEVVHWLVNNVEGVQTQAMAIDIMQKMLEEQLIVHASGEALRTFIYGFYFYKIVVDKEPDRVGMQQPAMWHTAAMDDFSAFQRKWFEVAFVAEELLHSEIPAFFLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNVSCLVKEGSEHLFDGFEPETYWDRMHLLQEAIAYRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSCGQQRRRRNSTSSTNQNMFCEERIGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCWNKDSRLVLFWTDCLDKMHASAP", "length": 1602 }, "evidence": [ { "id": "F1MN63", "url": "https://omabrowser.org/oma/group/F1MN63/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O75140-10", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "DEPDC5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKEDLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFTPRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTTCRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHLHQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTSPDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKDGAFFMEFVRSPRTASSAFYPQVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFWTSCLEKMHASAP", "length": 1603 }, "evidence": [ { "id": "F1MN63", "url": "https://omabrowser.org/oma/group/F1MN63/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "F1MN63", "url": "https://www.uniprot.org/uniprotkb/F1MN63" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "F1MN63", "url": "https://www.uniprot.org/uniprotkb/F1MN63" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "F1MN63", "url": "https://www.uniprot.org/uniprotkb/F1MN63" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MN63", "url": "https://www.uniprot.org/uniprotkb/F1MN63" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1MN63", "url": "https://www.uniprot.org/uniprotkb/F1MN63" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "F1MN63", "url": "https://www.uniprot.org/uniprotkb/F1MN63" } ], "pmid": "" }, { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "F1MN63", "url": "https://www.uniprot.org/uniprotkb/F1MN63" } ], "pmid": "" }, { "name": "GATOR1 complex", "id": "GO:1990130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990130", "evidence": [ { "database": "UniProtKB", "id": "F1MN63", "url": "https://www.uniprot.org/uniprotkb/F1MN63" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1MN63", "url": "https://www.uniprot.org/uniprotkb/F1MN63" } ], "pmid": "" }, { "name": "positive regulation of autophagy", "id": "GO:0010508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "database": "UniProtKB", "id": "F1MN63", "url": "https://www.uniprot.org/uniprotkb/F1MN63" } ], "pmid": "" }, { "name": "cellular response to amino acid starvation", "id": "GO:0034198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", "evidence": [ { "database": "UniProtKB", "id": "F1MN63", "url": "https://www.uniprot.org/uniprotkb/F1MN63" } ], "pmid": "" }, { "name": "negative regulation of TORC1 signaling", "id": "GO:1904262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904262", "evidence": [ { "database": "UniProtKB", "id": "F1MN63", "url": "https://www.uniprot.org/uniprotkb/F1MN63" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1157, "end_pos": 1159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1361, "end_pos": 1363, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1376, "end_pos": 1378, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1443, "end_pos": 1445, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1528, "end_pos": 1530, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 404, "end_pos": 406, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN63" }, { "id": "PS50186", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50186" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DEP", "eco_id": "ECO_0000259", "start_pos": 1187, "end_pos": 1262, "start_aa": "Pro", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1157, "end_pos": 1159 }, { "start_pos": 1361, "end_pos": 1363 }, { "start_pos": 1376, "end_pos": 1378 }, { "start_pos": 1443, "end_pos": 1445 }, { "start_pos": 1528, "end_pos": 1530 }, { "start_pos": 211, "end_pos": 213 }, { "start_pos": 298, "end_pos": 300 }, { "start_pos": 311, "end_pos": 313 }, { "start_pos": 384, "end_pos": 386 }, { "start_pos": 404, "end_pos": 406 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1ML97-1", "uniprot_ac": "F1ML97", "uniprot_id": "F1ML97_BOVIN", "mass": { "chemical_mass": 81230.0, "monoisotopic_mass": 81230.0 }, "refseq": {}, "gene_names": [ { "name": "NOA1A", "type": "recommended", "evidence": [ { "id": "F1ML97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML97" } ] } ], "protein_names": [ { "name": "Nitric oxide associated 1 A", "type": "synonym", "evidence": [ { "id": "F1ML97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML97/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1ML97", "url": "https://www.uniprot.org/uniprotkb/F1ML97" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NOA1A", "url": "https://www.uniprot.org/uniprotkb/F1ML97", "locus": { "chromosome": "6", "start_pos": 72349439, "end_pos": 72361031, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019362", "url": "https://www.ensembl.org/id/ENSBTAG00000019362" } ] } } ], "crossref": [ { "id": "F1ML97", "url": "https://alphafold.ebi.ac.uk/entry/F1ML97", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019362", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019362", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01855", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01855", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR006073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052807", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052807", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LGCTNVG", "url": "https://omabrowser.org/oma/group/LGCTNVG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR46406", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46406", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46406:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46406:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01926", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01926", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21516", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1M181", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M181", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M181-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M181-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML97", "url": "https://www.uniprot.org/uniprotkb/F1ML97", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML97-1", "url": "https://www.uniprot.org/uniprotkb/F1ML97-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTALWNSWPVPAVLRSSGATVRVRKGGSALLPTPAFLMLPARLARRLLCGFLRGPTPIVTRNGVRETLLERRCATDYSSRHSAGLGRGLPRGATATGGNPGGADLEESFLFPEYVLDSESEATLQDQLRELQQRQEEEERRIEQQREERRQQKLGAGRRVHQVVGHPDPTVPPSGQNCSGCGAELHCQDPGVPGYLPSEKFNSAVAEEGGLERTVCQRCWLLVHHRRALRLQVSQGQFLELVSAALRRPEPALVLYMVDLLDLPDTLLPHLPALVGPKQLIVLGNKVDLLPQDTPNYRQRLRERLWDECIGAGLLPPRGYRRAQRSSGDRPRGGEDNANLPSKSSTVLRDVRLISAKTGYGVEELISALQRSWRYRGDVYLVGSTNAGKSTLFNTLLESDYCIAKGAEAIDRATISPWPGTTLNLLKFPICNPTPYRMFQRQKRLKRDATEAEEDLSQQEQNKLNLLKKHGYLVGRVGRTFSYSEAQKDKAAFEFDADSFAFDMGNEPVLAADKSTKRVELTPEDVKDAHWFYDTPGITKENCILSLLTEKEVNIVLPTHSIIPRTFMLKPGMVLFLGALGRIDFLKGNQSAWFTVVASSFLPVHITSLDKADTMYQKHAGHMLLKVPVGGEERMAGFPPLVAEDITLDEGLGESEAVADIKFSSAGWVAVTPQFKDTLTLRGYTPQGTVLTVRRPLLPHIVNIKGKRIKGSVAYKTKRPPALMYNLQKKR", "length": 731, "header": "tr|F1ML97-1|F1ML97_BOVIN Isoform 1 of Nitric oxide associated 1 A OS=Bos taurus OX=9913 GN=NOA1A PE=4 SV=2 CANONICAL=F1ML97-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M181-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M181/entry", "sequence": { "sequence": "MTALWNSWPVPAVLRSSGATVRVRKGGSALLPTPAFLMLPARLARRLLCGFLRGPTPIVTRNGVRETLLERRCATDYSSRHSAGLGRGLPRGATATGGNPGGADLEESFLFPEYVLDSESEATLQDQLRELQQRQEEEERRIEQQREERRQQKLGAGRRVHQVVGHPDPTVPPSGQNCSGCGAELHCQDPGVPGYLPSEKFNSAVAEEGGLERTVCQRCWLLVHHRRALRLQVSQGQFLELVSAALRRPEPALVLYMVDLLDLPDTLLPHLPALVGPKQLIVLGNKVDLLPQDTPNYRQRLRERLWDECIGAGLLPPRGYRRAQRSSGDRPRGGEDNANLPSKSSTVLRDVRLISAKTGYGVEELISALQRSWRYRGDVYLVGSTNAGKSTLFNTLLESDYCIAKGAEAIDRATISPWPGTTLNLLKFPICNPTPYRMFQRQKRLKRDATEAEEDLSQQEQNKLNLLKKHGYLVGRVGRTFSYSEAQKDKAAFEFDADSFAFDMGNEPVLAADKSTKRVELTPEDVKDAHWFYDTPGITKENCILSLLTEKEVNIVLPTHSIIPRTFMLKPGMVLFLGALGRIDFLKGNQSAWFTVVASSFLPVHITSLDKADTMYQKHAGHMLLKVPVGGEERMAGFPPLVAEDITLDEGLGESEAVADIKFSSAAMGRREECEEHAATVLK", "length": 683, "header": "tr|A0A3Q1M181-1|F1ML97_BOVIN Computationally mapped isoform of Nitric oxide associated 1 A OS=Bos taurus OX=9913 GN=NOA1A PE=4 SV=2 CANONICAL=F1ML97-1" }, "locus": { "chromosome": "6", "start_pos": 72360994, "end_pos": 72350329, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000071135.2", "url": "https://www.ensembl.org/id/ENSBTAT00000071135.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063454.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063454.2" } ] } }, { "isoform_ac": "F1ML97-1", "url": "https://www.uniprot.org/uniprotkb/F1ML97/entry", "sequence": { "sequence": "MTALWNSWPVPAVLRSSGATVRVRKGGSALLPTPAFLMLPARLARRLLCGFLRGPTPIVTRNGVRETLLERRCATDYSSRHSAGLGRGLPRGATATGGNPGGADLEESFLFPEYVLDSESEATLQDQLRELQQRQEEEERRIEQQREERRQQKLGAGRRVHQVVGHPDPTVPPSGQNCSGCGAELHCQDPGVPGYLPSEKFNSAVAEEGGLERTVCQRCWLLVHHRRALRLQVSQGQFLELVSAALRRPEPALVLYMVDLLDLPDTLLPHLPALVGPKQLIVLGNKVDLLPQDTPNYRQRLRERLWDECIGAGLLPPRGYRRAQRSSGDRPRGGEDNANLPSKSSTVLRDVRLISAKTGYGVEELISALQRSWRYRGDVYLVGSTNAGKSTLFNTLLESDYCIAKGAEAIDRATISPWPGTTLNLLKFPICNPTPYRMFQRQKRLKRDATEAEEDLSQQEQNKLNLLKKHGYLVGRVGRTFSYSEAQKDKAAFEFDADSFAFDMGNEPVLAADKSTKRVELTPEDVKDAHWFYDTPGITKENCILSLLTEKEVNIVLPTHSIIPRTFMLKPGMVLFLGALGRIDFLKGNQSAWFTVVASSFLPVHITSLDKADTMYQKHAGHMLLKVPVGGEERMAGFPPLVAEDITLDEGLGESEAVADIKFSSAGWVAVTPQFKDTLTLRGYTPQGTVLTVRRPLLPHIVNIKGKRIKGSVAYKTKRPPALMYNLQKKR", "length": 731, "header": "tr|F1ML97-1|F1ML97_BOVIN Isoform 1 of Nitric oxide associated 1 A OS=Bos taurus OX=9913 GN=NOA1A PE=4 SV=2 CANONICAL=F1ML97-1" }, "locus": { "chromosome": "6", "start_pos": 72360994, "end_pos": 72350850, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025792.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025792.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025792.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025792.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 170, "start_aa": "Thr", "end_pos": 170, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr170", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 33, "start_aa": "Thr", "end_pos": 33, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr33", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 672, "start_aa": "Thr", "end_pos": 672, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr672", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K602-1", "protein_name": "Nitric oxide associated 1", "gene_name": "Noa1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLPARLGCRLLCGLLRGPAPAAACRGPARWLLEGKCEATICQRGSSLGRRAPPSSTATEDCEEGTDTEERFLFPEYVPERTPEEQLRELRELRELQQLQQEKERQRLQRREERLQQKLRAGLRALPVPELPDASVPPSGIYCSGCGAELHCQHPGLPGYLPGEKFRDAAQAEGGLARTVCQRCWLLVHHRRALRLQVSRDQYLELVSTALQRPGPALVLYMVDLLDLPDALLPDLPKLVGPKQLFVLGNKVDLLPQDAPGYLQRLRKRLWNDCIRAGLVVAPGHRGPQYPTGNEPLDEIKNQNPSSRSRTVVKDVRLISAKTGYGVEELISALQRSWRYRGDVYLVGTTNAGKSTLFNTLLESDYCTAKGSEAIDRATISPWPGTTLNLLKFPICNPTPYRMFKRQKRLQEDASKTEEDLSEQEQSQLNQLKKHGYIVGRVGRTFLHSRQQKEEVPFEFDADSLAFDMGNEPVVSVRKSTKQTELTPEDVKDAHWFYDTPGITKENCILNLLTEKEIDIVLPTHSIIPRTFVLKPGMVLFLGGIARVDFLQGNQSAWFTVVASNFLPVHISSLDKADALYEKHAGQELLLVPMGGKERMAQFPPLVAEDITLKGGGEAEAVADIKFSSAGWVAVTPYSEGTLHLRAYTPEGTALTVHPPVLPYIVNVKGQRIKKSAAYKTKKPPSLIHNLKKHR", "length": 694 }, "evidence": [ { "id": "F1ML97", "url": "https://omabrowser.org/oma/group/F1ML97/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A287A8M3-1", "protein_name": "Nitric oxide associated 1", "gene_name": "NOA1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLPTRLAPRLLCGFLQGASPTAARLGLQDALLERRCAASLSSQRPWALGRGRSRYRTATGGSEGRADLEESFLFPEYIPEPEPAPTLQDQLREVQQRQEENERQMQQRREERRQQKLRAARRVQRAQPVVGHPDPTVAPSGLNCSGCGAELHCQDPGVPGYLPSEKFLRAAAQADGGLARTVCQRCWLLVHHRRALRLQVSPEKYLELVSAALRRPEPALVLYMVDLLDLPDALLRHLPALVGPKQLIVLGNKVDLLPQDAPGYRQRIRERLWDDCARVGLLPPPGSRRSQHPGRKQPRDQAEKANHSAKSRAVLRDVRLISAKTGYGVEELISALQRSWRYRGDVYLVGATNAGKSTLFNTLLESDYCIAKGAEAIDRATISAWPGTTLNLLKFPICNPTPYRMFQRQKRLKRDAVEAEEDLSQQEQNQLNLLKKHGYVVGRVGRTFSCSEQKEEAAFEFDANSLAFDMGDDPVMVADKPTRRIELTPQDVKDARWFYDTPGITKDNCILNLLTEKEVNIVLPTQAIVPRTFVLQPGMVLFLGAIGRIDFLQGNQSAWFTVVASNFLPVHITSLDKADTVYKKHAGHTLLKVPVGGKERMAGFPPLVAEDITLDEGLGESEAVADIKFSSAGWVAVTPQFKDRLHLRGHMPQGTFLTVRPPLLPHIVNIKGPRIQRSVAYQTKKPPPLVYNVQKKKKR", "length": 699 }, "evidence": [ { "id": "F1ML97", "url": "https://omabrowser.org/oma/group/F1ML97/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XL92-1", "protein_name": "Nitric oxide associated 1", "gene_name": "NOA1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MLRLGRALLGRLRPARPWAARRGAAAAAGGEEERFVFLEYEPEPPPPPLLPPPPPPAASARGREAVRSRAAGRDGAREGDRVRGVADLSVPPSGVGCSGCGAELQCRDAAAPGFVPADKYRSLCAGPDGTAGLRDAVCQRCWVLEHGGRVVRLDLPPEQHRAVLSAALRSPPRHGRGPLLLYLLDVLELPDPVLPQLPALLSPEVPAAGLLVVGNKVDLLPADSPGHLGRLRQRVTAACLQAGISRAQLVDVRLVSAKTGFGIERLVSRLQRSWKCAGDVYLLGATNSGKSTLFNALLLSDYCKSRAPDVVNRATVSSWPGTTLNLLKFPIINPTCDRIFRRQERLKEEALKTEDQLSDKEKKHLNRLKKQGYLVGRVGRTFKPQKESSVIDFDPDLLSYSIDEDPCHIPKKHEEREEFTYNEVKDARWCFDTPGIVKENCVLNLLTEKEVKLVLPTQAIIPRTFILKPGMVLFLAALGRVDYLQGEKPAWFSVVASKLLPVHIAALSSADAMYEKYAGQEFFKVPMGGKERMKEFPPLVPQDITLKGTGTTEAVADIKLSSAGWVAVTAHAEEELLLRAYTPRGTTVVVREPPLLPYISNIRGARIPGTAAYRTKKPPSLVENLKTVGNR", "length": 631 }, "evidence": [ { "id": "F1ML97", "url": "https://omabrowser.org/oma/group/F1ML97/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8NC60-1", "protein_name": "Nitric oxide-associated protein 1", "gene_name": "NOA1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLPARLPFRLLSLFLRGSAPTAARHGLREPLLERRCAAASSFQHSSSLGRELPYDPVDTEGFGEGGDMQERFLFPEYILDPEPQPTREKQLQELQQQQEEEERQRQQRREERRQQNLRARSREHPVVGHPDPALPPSGVNCSGCGAELHCQDAGVPGYLPREKFLRTAEADGGLARTVCQRCWLLSHHRRALRLQVSREQYLELVSAALRRPGPSLVLYMVDLLDLPDALLPDLPALVGPKQLIVLGNKVDLLPQDAPGYRQRLRERLWEDCARAGLLLAPGHQGPQRPVKDEPQDGENPNPPNWSRTVVRDVRLISAKTGYGVEELISALQRSWRYRGDVYLVGATNAGKSTLFNTLLESDYCTAKGSEAIDRATISPWPGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLTEKEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTVLTVRPPLLPYIVNIKGQRIKKSVAYKTKKPPSLMYNVRKKKGKINV", "length": 698 }, "evidence": [ { "id": "F1ML97", "url": "https://omabrowser.org/oma/group/F1ML97/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JJG9-1", "protein_name": "Nitric oxide-associated protein 1", "gene_name": "Noa1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPARLACGLLCGLRRGPAPAAACYGPARWLLEGKCEVPIRQRASSLGRRVPPSSTATEDYAEGPDTEERFLFPEYVPERTPEEQVRELQELRELQQLQQEKERERLQQREERLQQKLRAGFRTLPVPEFPDASVPPSGIYCSGCGAELHCQHPGLPGYLPEEKFRDAAQAEGGPARTVCQRCWLLVHHGRALRLQVSRDQYLELVSAALRRPGPALVLYMVNLLDLPDALLPDLPKLVGPKQLIVLGNKVDLLPQDAPGYLKRLRKRLWDDCIRAGLVVAPGHQGPQYPAGDEPLEEIKNQNPSSRSRTVVKDVRLISAKTGYGVEEMISALQRSWRYRGDVYLVGTTNAGKSTLFNTLLESDYCTAKGSEAIDRATISPWPGTTLNLLKFPICNPTPYRMFKRQRRLQEDATKAEEDLSEEEQSQLNQLKKHGYIVGRVGRTFSYSREQDEVPFEFDADSLAFDMGSEPVVSVCKSTKQIELTPEDVKDAHWFYDTPGITKESCILNLLTEKEINTVLPTHSIIPRTFVLKPGMVLFLGGIARIDFLQGNQSAWFTVVASNFLPVHITSLDKADALYEKHAGHELLLVPMGGKERMAQFPPLVAEDITLKGGGKFEAVADIKFSSAGWVAVTPYSEGTLHLRGHTPEGTALTVHPPVLPYIVNVKGQRMKKSVAYKTKKPPSLVHNLKKHR", "length": 693 }, "evidence": [ { "id": "F1ML97", "url": "https://omabrowser.org/oma/group/F1ML97/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1ML97", "url": "https://www.uniprot.org/uniprotkb/F1ML97" } ], "pmid": "" }, { "name": "RNA folding chaperone", "id": "GO:0140691", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140691", "evidence": [ { "database": "UniProtKB", "id": "F1ML97", "url": "https://www.uniprot.org/uniprotkb/F1ML97" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "F1ML97", "url": "https://www.uniprot.org/uniprotkb/F1ML97" } ], "pmid": "" }, { "name": "matrix side of mitochondrial inner membrane", "id": "GO:0099617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099617", "evidence": [ { "database": "UniProtKB", "id": "F1ML97", "url": "https://www.uniprot.org/uniprotkb/F1ML97" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "mitochondrion organization", "id": "GO:0007005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005", "evidence": [ { "database": "UniProtKB", "id": "F1ML97", "url": "https://www.uniprot.org/uniprotkb/F1ML97" } ], "pmid": "" }, { "name": "mitochondrial small ribosomal subunit assembly", "id": "GO:0180026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0180026", "evidence": [ { "database": "UniProtKB", "id": "F1ML97", "url": "https://www.uniprot.org/uniprotkb/F1ML97" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 177, "end_pos": 179, "annotation": "n_glycosylation_sequon" }, { "start_pos": 589, "end_pos": 591, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1ML97-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 731, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1ML97-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ML97" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1ML97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML97" }, { "id": "PS51721", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51721" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CP-type G", "eco_id": "ECO_0000259", "start_pos": 239, "end_pos": 541, "start_aa": "Leu", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 33, 170, 672 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 177, "end_pos": 179 }, { "start_pos": 589, "end_pos": 591 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 3 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 3 }, { "field": "exact_o_linked_sites", "count": 3 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MNI7-1", "uniprot_ac": "F1MNI7", "uniprot_id": "F1MNI7_BOVIN", "mass": { "chemical_mass": 63297.0, "monoisotopic_mass": 63297.0 }, "refseq": { "ac": "NP_001179478", "name": "protein AF-9", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179478" }, "gene_names": [ { "name": "MLLT3", "type": "recommended", "evidence": [ { "id": "F1MNI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI7" } ] }, { "name": "MLLT3", "type": "synonym", "evidence": [ { "id": "NP_001179478", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179478" } ] } ], "protein_names": [ { "name": "MLLT3 super elongation complex subunit", "type": "synonym", "evidence": [ { "id": "F1MNI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNI7/entry#names_and_taxonomy" } ] }, { "name": "myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog", "type": "synonym", "evidence": [ { "id": "NP_001179478", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179478" } ] }, { "name": "myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)", "type": "synonym", "evidence": [ { "id": "NP_001179478", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179478" } ] }, { "name": "protein AF-9", "type": "synonym", "evidence": [ { "id": "NP_001179478", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179478" } ] }, { "name": "translocated to, 3", "type": "synonym", "evidence": [ { "id": "NP_001179478", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179478" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MNI7", "url": "https://www.uniprot.org/uniprotkb/F1MNI7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MLLT3", "url": "https://www.uniprot.org/uniprotkb/F1MNI7", "locus": { "chromosome": "8", "start_pos": 24069145, "end_pos": 23784620, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014124", "url": "https://www.ensembl.org/id/ENSBTAG00000014124" } ] } } ], "crossref": [ { "id": "F1MNI7", "url": "https://alphafold.ebi.ac.uk/entry/F1MNI7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014124", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014124", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16906", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16906", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "521962", "url": "https://www.ncbi.nlm.nih.gov/gene/521962", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR038704", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038704", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040930", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040930", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055129", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055129", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:521962", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521962", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MASSXCK", "url": "https://omabrowser.org/oma/group/MASSXCK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M372", "url": "https://www.orthodb.org/?gene=A0A3Q1M372", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MNI7", "url": "https://www.orthodb.org/?gene=F1MNI7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47827", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47827", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47827:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47827:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03366", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03366", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17793", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17793", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-112382", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112382", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-674695", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75955", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75955", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179478", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M372", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M372", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M372-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M372-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9G4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9G4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9G4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9G4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNI7", "url": "https://www.uniprot.org/uniprotkb/F1MNI7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNI7-1", "url": "https://www.uniprot.org/uniprotkb/F1MNI7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEEFRRKLLKAGGDPNRSIHTSSSSSSSSCSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENMSSKSDSEQPSPASSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEAEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS", "length": 567, "header": "tr|F1MNI7-1|F1MNI7_BOVIN Isoform 1 of MLLT3 super elongation complex subunit OS=Bos taurus OX=9913 GN=MLLT3 PE=4 SV=2 CANONICAL=F1MNI7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M372-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M372/entry", "sequence": { "sequence": "MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEEFRRKLLKAGGDPNRSIHTSSSSSSSSCSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENMSSKSDSEQPSPASSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEAEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS", "length": 543, "header": "tr|A0A3Q1M372-1|F1MNI7_BOVIN Computationally mapped isoform of MLLT3 super elongation complex subunit OS=Bos taurus OX=9913 GN=MLLT3 PE=4 SV=2 CANONICAL=F1MNI7-1" }, "locus": { "chromosome": "8", "start_pos": 24068497, "end_pos": 23784860, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000067312.2", "url": "https://www.ensembl.org/id/ENSBTAT00000067312.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000062592.2", "url": "https://www.ensembl.org/id/ENSBTAP00000062592.2" } ] } }, { "isoform_ac": "A0AAA9S9G4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9G4/entry", "sequence": { "sequence": "MCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEEFRRKLLKAGGDPNRSIHTSSSSSSSSCSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENMSSKSDSEQPSPASSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEAEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS", "length": 564, "header": "tr|A0AAA9S9G4-1|F1MNI7_BOVIN Computationally mapped isoform of MLLT3 super elongation complex subunit OS=Bos taurus OX=9913 GN=MLLT3 PE=4 SV=1 CANONICAL=F1MNI7-1" }, "locus": { "chromosome": "8", "start_pos": 24068497, "end_pos": 23785323, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110120.2", "url": "https://www.ensembl.org/id/ENSBTAT00000110120.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080570.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080570.1" } ] } }, { "isoform_ac": "F1MNI7-1", "url": "https://www.uniprot.org/uniprotkb/F1MNI7/entry", "sequence": { "sequence": "MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEEFRRKLLKAGGDPNRSIHTSSSSSSSSCSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENMSSKSDSEQPSPASSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEAEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS", "length": 567, "header": "tr|F1MNI7-1|F1MNI7_BOVIN Isoform 1 of MLLT3 super elongation complex subunit OS=Bos taurus OX=9913 GN=MLLT3 PE=4 SV=2 CANONICAL=F1MNI7-1" }, "locus": { "chromosome": "8", "start_pos": 24068497, "end_pos": 23784860, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018772.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018772.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018772.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018772.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:521962", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:521962", "resource": "KEGG Pathway" }, { "id": "R-BTA-112382", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-112382", "resource": "Reactome", "description": "Formation of RNA Pol II elongation complex" }, { "id": "R-BTA-674695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-674695", "resource": "Reactome", "description": "RNA Polymerase II Pre-transcription Events" }, { "id": "R-BTA-75955", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75955", "resource": "Reactome", "description": "RNA Polymerase II Transcription Elongation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287A4E4-1", "protein_name": "MLLT3 super elongation complex 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norvegicus", "sequence": { "sequence": "MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKDSSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKADSNLLTVTSAQQDKKAPSKRPPVSDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENMSSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEAEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS", "length": 569 }, "evidence": [ { "id": "F1MNI7", "url": "https://omabrowser.org/oma/group/F1MNI7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A2AM29-1", "protein_name": "Protein AF-9", "gene_name": "Mllt3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"MAGACAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEEFRRKLLKAGGIMVMTDGTSFSSGQSLHLPNLPSNSLSFSEVKKKSSHGPKDPTKILNINSSSGSTNSFSKPHKLTKEHKEKTSKDSKEQKSAFKEPSREHNKSSKESSKKPKENKPLKDEKLVPKMAFKEPKSMSKEPKSENTPILTITGGQQQEKKTPIKRPSVLDSDEPSAKKRKKNVSESLFKSFPNAPSLVLTCSADKKQTKDRSQLKMGRVKIESDTLEKKTSTLPPFDDIIDPNDSDVEENMSSKSESDQPSPASSSSSSSSSFTPSQNSRQQGPLRSIMKDLHSDDNEDESEEPDDNDNDSELERPVNTRGGSRSRRVSLSDGSDSDSNSASSPPRHEPAPPLLKTNSNQILEVKSPIKQNKSDKQIKNGDCDKAYLDELVELHRRLMTLRERHVLQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS", "length": 578 }, "evidence": [ { "id": "F1MNI7", "url": "https://omabrowser.org/oma/group/F1MNI7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "P42568-1", "protein_name": "Protein AF-9", "gene_name": "MLLT3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS", "length": 568 }, "evidence": [ { "id": "F1MNI7", "url": "https://omabrowser.org/oma/group/F1MNI7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MNI7", "url": "https://www.uniprot.org/uniprotkb/F1MNI7" } ], "pmid": "" }, { "name": "transcription elongation factor complex", "id": "GO:0008023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008023", "evidence": [ { "database": "UniProtKB", "id": "F1MNI7", "url": "https://www.uniprot.org/uniprotkb/F1MNI7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MNI7", "url": "https://www.uniprot.org/uniprotkb/F1MNI7" } ], "pmid": "" }, { "name": "hematopoietic stem cell differentiation", "id": "GO:0060218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060218", "evidence": [ { "database": "UniProtKB", "id": "F1MNI7", "url": "https://www.uniprot.org/uniprotkb/F1MNI7" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "F1MNI7", "url": "https://www.uniprot.org/uniprotkb/F1MNI7" } ], "pmid": "" }, { "name": "regulation of stem cell division", "id": "GO:2000035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000035", "evidence": [ { "database": "UniProtKB", "id": "F1MNI7", "url": "https://www.uniprot.org/uniprotkb/F1MNI7" } ], "pmid": "" }, { "name": "regulation of chromatin organization", "id": "GO:1902275", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902275", "evidence": [ { "database": "UniProtKB", "id": "F1MNI7", "url": "https://www.uniprot.org/uniprotkb/F1MNI7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "F1MNI7", "url": "https://www.uniprot.org/uniprotkb/F1MNI7" } ], "pmid": "" }, { "name": "histone binding", 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"end_pos": 33935895, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000859", "url": "https://www.ensembl.org/id/ENSBTAG00000000859" } ] } } ], "crossref": [ { "id": "F1MTX9", "url": "https://alphafold.ebi.ac.uk/entry/F1MTX9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000859", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000859", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "527491", "url": "https://www.ncbi.nlm.nih.gov/gene/527491", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:527491", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527491", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CSAMAIY", "url": "https://omabrowser.org/oma/group/CSAMAIY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MTX9", "url": "https://www.orthodb.org/?gene=F1MTX9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22950", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22950", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22950:SF184", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22950:SF184", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01490", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01490", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-210455", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-210455", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-352230", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002687367", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687367", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5K8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M5K8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTX9", "url": "https://www.uniprot.org/uniprotkb/F1MTX9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTX9-1", "url": "https://www.uniprot.org/uniprotkb/F1MTX9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDDYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKLVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEEEFSAWYVDGRLLVVVVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFKITCSVPELNSTIPNSTNPDMCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYESVQSDLLHKYQSKNDILILTVRLAVIMAVILTVPVLFFTVRSSLFELAKKTKFNLCRHVLVTILLLVIINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITSQDGDKGTQQIWAALFLGLGVLFSLVSIPLVIYDWAYSSSGDEGH", "length": 486, "header": "tr|F1MTX9-1|F1MTX9_BOVIN Isoform 1 of Solute carrier family 38 member 1 OS=Bos taurus OX=9913 GN=SLC38A1 PE=4 SV=3 CANONICAL=F1MTX9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M5K8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5K8/entry", "sequence": { "sequence": "MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDDYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKLVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEEEFSAWYVDGRLLVVVVTFGIILPLCLLKNLELNSTIPNSTNPDMCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYESVQSDLLHKYQSKNDILILTVRLAVIMAVILTVPVLFFTVRSSLFELAKKTKFNLCRHVLVTILLLVIINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITSQDGDKGTQQIWAALFLGLGVLFSLVSIPLVIYDWAYSSSGDEGH", "length": 453, "header": "tr|A0A3Q1M5K8-1|F1MTX9_BOVIN Computationally mapped isoform of Solute carrier family 38 member 1 OS=Bos taurus OX=9913 GN=SLC38A1 PE=4 SV=2 CANONICAL=F1MTX9-1" }, "locus": { "chromosome": "5", "start_pos": 33993302, "end_pos": 33940660, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076857.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076857.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000065204.2", "url": "https://www.ensembl.org/id/ENSBTAP00000065204.2" } ] } }, { "isoform_ac": "F1MTX9-1", "url": "https://www.uniprot.org/uniprotkb/F1MTX9/entry", "sequence": { "sequence": "MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDDYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKLVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEEEFSAWYVDGRLLVVVVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFKITCSVPELNSTIPNSTNPDMCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYESVQSDLLHKYQSKNDILILTVRLAVIMAVILTVPVLFFTVRSSLFELAKKTKFNLCRHVLVTILLLVIINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITSQDGDKGTQQIWAALFLGLGVLFSLVSIPLVIYDWAYSSSGDEGH", "length": 486, "header": "tr|F1MTX9-1|F1MTX9_BOVIN Isoform 1 of Solute carrier family 38 member 1 OS=Bos taurus OX=9913 GN=SLC38A1 PE=4 SV=3 CANONICAL=F1MTX9-1" }, "locus": { "chromosome": "5", "start_pos": 33993302, "end_pos": 33940660, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001147.8", "url": "https://www.ensembl.org/id/ENSBTAT00000001147.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001147.6", "url": "https://www.ensembl.org/id/ENSBTAP00000001147.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:527491", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:527491", "resource": "KEGG Pathway" }, { "id": "R-BTA-210455", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-210455", "resource": "Reactome", "description": "Astrocytic Glutamate-Glutamine Uptake And Metabolism" }, { "id": "R-BTA-352230", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-352230", "resource": "Reactome", "description": "Amino acid transport across the plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "F1NYN5-1", "protein_name": "Solute carrier family 38 member 1", "gene_name": "SLC38A1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPFKAGLELTELQNMTIPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGIVLFSLLLVSVTLLSIYSIHLLLVCSKETGCMVYEKLGEQVFGTPGKMIVFGSTSLQNIGAMLSYLFIVKNELPSAIKFLMGKEETFSAWYVDGRILVVAVTFIIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQILCLESALNATSPILSNSSAHEHMCKPKYVIFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQLVSNISFFAMFVMYFLTAIFGYLTFYENVQSDLLHKYQSKDDILILTVRLAVIVAVILTVPVLFFTVRSSLFELARKTKFDIGRHVLVTFFLLVIINLLVIFIPTMKDIFGVVGVTSANMLIFILPSSLYLKITHQDGAKFTQRIWASLFLVLGIMFSLVSIPLVIYDWVQSGGSTEGSD", "length": 490 }, "evidence": [ { "id": "F1MTX9", "url": "https://omabrowser.org/oma/group/F1MTX9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8K2P7-1", "protein_name": "Sodium-coupled neutral amino acid symporter 1", "gene_name": "Slc38a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMHFKSGLELTELQNMTVPEDDNVSNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKRKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLILLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKLVIFGATSLQNTGAMLSYLFIVKNELPSAIKSLMGEEDAFSAWYVDGRVLVVMVTFGIILPLCLLKNLGYLGYTSGFSLSCMMFFLIVVIYKKFQTPCMSVEQNSTVSANVTDACTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYEKVQSDLLHKYQSTGDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFHLCRHVLVTIILLIIINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITNQDGDKGTQRIWAALFLGLGVLFSLISIPLVIYDWACSSGTDEGH", "length": 485 }, "evidence": [ { "id": "F1MTX9", "url": "https://omabrowser.org/oma/group/F1MTX9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H2H9-1", "protein_name": "Sodium-coupled neutral amino acid symporter 1", "gene_name": "SLC38A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEETFSAWYVDGRVLVVIVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCIVPELNSTISANSTNADTCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFNLCRHTVVTCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITDQDGDKGTQRIWAALFLGLGVLFSLVSIPLVIYDWACSSSSDEGH", "length": 487 }, "evidence": [ { "id": "F1MTX9", "url": "https://omabrowser.org/oma/group/F1MTX9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JM15-1", "protein_name": "Sodium-coupled neutral amino acid symporter 1", "gene_name": "Slc38a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMHFKSGLELTELQNMTVPEDDNVSNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKRKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLILLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKLVIFGATSLQNTGAMLSYLFIVKNELPSAIKSLMGEEETFSAWYVDGRVLVVMVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCMNGEQNSTVSANVTDACTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYEKVQSDLLHKYQSTGDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFHLCRHVLVTIILLVIINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITNQDGDKNTQRIWAALFLALGVLFSLISIPLVIYDWACSSSNGEGH", "length": 485 }, "evidence": [ { "id": "F1MTX9", "url": "https://omabrowser.org/oma/group/F1MTX9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MTX9", "url": "https://www.uniprot.org/uniprotkb/F1MTX9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MTX9", "url": "https://www.uniprot.org/uniprotkb/F1MTX9" } ], "pmid": "" }, { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "F1MTX9", "url": "https://www.uniprot.org/uniprotkb/F1MTX9" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "F1MTX9", "url": "https://www.uniprot.org/uniprotkb/F1MTX9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of synaptic plasticity", "id": "GO:0048167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048167", "evidence": [ { "database": "UniProtKB", "id": "F1MTX9", "url": "https://www.uniprot.org/uniprotkb/F1MTX9" } ], "pmid": "" }, { "name": "glutamine transport", "id": "GO:0006868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006868", "evidence": [ { "database": "UniProtKB", "id": "F1MTX9", "url": "https://www.uniprot.org/uniprotkb/F1MTX9" } ], "pmid": "" }, { "name": "amino acid transmembrane transport", "id": "GO:0003333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003333", "evidence": [ { "database": "UniProtKB", "id": "F1MTX9", "url": "https://www.uniprot.org/uniprotkb/F1MTX9" } ], "pmid": "" }, { "name": "regulation of synaptic transmission, GABAergic", "id": "GO:0032228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032228", "evidence": [ { "database": "UniProtKB", "id": "F1MTX9", "url": "https://www.uniprot.org/uniprotkb/F1MTX9" } ], "pmid": "" }, { "name": "gamma-aminobutyric acid biosynthetic process", "id": "GO:0009449", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009449", "evidence": [ { "database": "UniProtKB", "id": "F1MTX9", "url": "https://www.uniprot.org/uniprotkb/F1MTX9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "L-glutamine transmembrane transporter activity", "id": "GO:0015186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015186", "evidence": [ { "database": "UniProtKB", "id": "F1MTX9", "url": "https://www.uniprot.org/uniprotkb/F1MTX9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 15, "end_pos": 17, "annotation": "n_glycosylation_sequon" }, { "start_pos": 23, "end_pos": 25, "annotation": "n_glycosylation_sequon" }, { "start_pos": 251, "end_pos": 253, "annotation": "n_glycosylation_sequon" }, { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 26, "end_pos": 28, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MTX9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 486, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MTX9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MTX9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MTX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTX9" }, { "id": "PF01490", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01490" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amino acid transporter transmembrane", "eco_id": "ECO_0000259", "start_pos": 70, "end_pos": 470, "start_aa": "Thr", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 15, "end_pos": 17 }, { "start_pos": 23, "end_pos": 25 }, { "start_pos": 251, "end_pos": 253 }, { "start_pos": 256, "end_pos": 258 }, { "start_pos": 26, "end_pos": 28 }, { "start_pos": 311, "end_pos": 313 }, { "start_pos": 79, "end_pos": 81 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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} ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1ML16-1", "uniprot_ac": "F1ML16", "uniprot_id": "F1ML16_BOVIN", "mass": { "chemical_mass": 91138.0, "monoisotopic_mass": 91138.0 }, "refseq": {}, "gene_names": [ { "name": "HIC1", "type": "recommended", "evidence": [ { "id": "F1ML16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ] } ], "protein_names": [ { "name": "Hypermethylated in cancer 1 protein", "type": "recommended", "evidence": [ { "id": "F1ML16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML16/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HIC1", "url": "https://www.uniprot.org/uniprotkb/F1ML16", "locus": { "chromosome": "19", "start_pos": 23085302, "end_pos": 23074885, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000025130", "url": "https://www.ensembl.org/id/ENSBTAG00000025130" } ] } } ], "crossref": [ { "id": "F1ML16", "url": "https://alphafold.ebi.ac.uk/entry/F1ML16", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000025130", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000025130", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "786191", "url": "https://www.ncbi.nlm.nih.gov/gene/786191", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:786191", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786191", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FLPYPKM", "url": "https://omabrowser.org/oma/group/FLPYPKM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24394:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24394:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3232118", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M853", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M853", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M853-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M853-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SX20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML16-1", "url": "https://www.uniprot.org/uniprotkb/F1ML16-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEFRNMYTGTFSSKPQFLWGSQVRGWGLQVGTSGRLNLRTGPPPGSSSSSASLHPRCAGRRPWLCRAKYRTAARWRHSCSSARRPGPLQIRVCGKRGGAETRPGRGEDGPAGQTDRGPGGRRAAQRSHVPPWIRRQPGPGLPTCPPGECAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYSSPAGPPPPPTAEPPSGPEAAVNTHCAELYASGPGPATALCAPERRCSPLCGLDLSKKSPPGSAPPERPPGERELPPRPDSPPSAGPAAYKEPPLTLPPLPPLPFQKLEEAGPPPDPFRGGGGSPGSEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDPSASPGGPPLGLAPPPRYAGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT", "length": 868, "header": "tr|F1ML16-1|F1ML16_BOVIN Isoform 1 of Hypermethylated in cancer 1 protein OS=Bos taurus OX=9913 GN=HIC1 PE=3 SV=4 CANONICAL=F1ML16-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M853-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M853/entry", "sequence": { "sequence": "MTFPEADIFLKSGECAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYSSPAGPPPPPTAEPPSGPEAAVNTHCAELYASGPGPATALCAPERRCSPLCGLDLSKKSPPGSAPPERPPGERELPPRPDSPPSAGPAAYKEPPLTLPPLPPLPFQKLEEAGPPPDPFRGGGGSPGSEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDPSASPGGPPLGLAPPPRYAGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT", "length": 733, "header": "tr|A0A3Q1M853-1|F1ML16_BOVIN Computationally mapped isoform of Hypermethylated in cancer 1 protein OS=Bos taurus OX=9913 GN=HIC1 PE=3 SV=1 CANONICAL=F1ML16-1" }, "locus": { "chromosome": "19", "start_pos": 23079159, "end_pos": 23076620, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000073950.2", "url": "https://www.ensembl.org/id/ENSBTAT00000073950.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070062.1", "url": "https://www.ensembl.org/id/ENSBTAP00000070062.1" } ] } }, { "isoform_ac": "A0AAA9SX20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX20/entry", "sequence": { "sequence": "MLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYSSPAGPPPPPTAEPPSGPEAAVNTHCAELYASGPGPATALCAPERRCSPLCGLDLSKKSPPGSAPPERPPGERELPPRPDSPPSAGPAAYKEPPLTLPPLPPLPFQKLEEAGPPPDPFRGGGGSPGSEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDPSASPGGPPLGLAPPPRYAGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT", "length": 714, "header": "tr|A0AAA9SX20-1|F1ML16_BOVIN Computationally mapped isoform of Hypermethylated in cancer 1 protein OS=Bos taurus OX=9913 GN=HIC1 PE=3 SV=1 CANONICAL=F1ML16-1" }, "locus": { "chromosome": "19", "start_pos": 23083126, "end_pos": 23080985, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119858.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119858.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089876.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089876.1" } ] } }, { "isoform_ac": "F1ML16-1", "url": "https://www.uniprot.org/uniprotkb/F1ML16/entry", "sequence": { "sequence": "MSEFRNMYTGTFSSKPQFLWGSQVRGWGLQVGTSGRLNLRTGPPPGSSSSSASLHPRCAGRRPWLCRAKYRTAARWRHSCSSARRPGPLQIRVCGKRGGAETRPGRGEDGPAGQTDRGPGGRRAAQRSHVPPWIRRQPGPGLPTCPPGECAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYSSPAGPPPPPTAEPPSGPEAAVNTHCAELYASGPGPATALCAPERRCSPLCGLDLSKKSPPGSAPPERPPGERELPPRPDSPPSAGPAAYKEPPLTLPPLPPLPFQKLEEAGPPPDPFRGGGGSPGSEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDPSASPGGPPLGLAPPPRYAGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT", "length": 868, "header": "tr|F1ML16-1|F1ML16_BOVIN Isoform 1 of Hypermethylated in cancer 1 protein OS=Bos taurus OX=9913 GN=HIC1 PE=3 SV=4 CANONICAL=F1ML16-1" }, "locus": { "chromosome": "19", "start_pos": 23079159, "end_pos": 23075084, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000055247.4", "url": "https://www.ensembl.org/id/ENSBTAT00000055247.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049772.4", "url": "https://www.ensembl.org/id/ENSBTAP00000049772.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 335, "start_aa": "Thr", "end_pos": 335, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr335", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:786191", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786191", "resource": "KEGG Pathway" }, { "id": "R-BTA-3232118", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3232118", "resource": "Reactome", "description": "SUMOylation of transcription factors" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A974-1", "protein_name": "Hypermethylated in cancer 1 protein", "gene_name": "Hic1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLDAMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLTDSVEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGSGGGGYAPYGRPGRGLRAATPVIQACYSSPAGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAASLCAPERRCSPLCGLDLSKKSPPGSSVPERPLSERELPPRPDSPPGAGPAVYKEPPLTLPPLPPLPFQKLEEAVPTPDPFRGSGGSPGPEPPGRPDGSSLLYRWMKHEPGLGSYGDELVRDRGSPGERLEERGGDPAASPGGPPLGLVPPPRYPGSLDGPGTGADGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGPPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDSRTIDRFSPA", "length": 714 }, "evidence": [ { "id": "F1ML16", "url": "https://omabrowser.org/oma/group/F1ML16/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3LGR3-1", "protein_name": "Hypermethylated in cancer 1 protein", "gene_name": "HIC1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTFPEADIFLKSGDCAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQTCYSSPAGPPPPPTAEPPSGPEAAVNTHCAELYASGPGPAAALCAPERRCSPLCGLDLSKKSPPGSAPPERPPGERELPPRPDSPPSAGPAAYKEPPLALPPLPPLPFQKLEEAGPPPDPFRGSGSPGPEPPGRPDGPSLLYRWMKHEPGLGSYGDDLGRERGSPSERCEERGGDPAASPGGPPLGLAPPPRYPGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPAGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEAALYGRAEAAEVAAGAAGLGPPFGGSGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGALPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT", "length": 733 }, "evidence": [ { "id": "F1ML16", "url": "https://omabrowser.org/oma/group/F1ML16/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q14526-1", "protein_name": "Hypermethylated in cancer 1 protein", "gene_name": "HIC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTFPEADILLKSGECAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYPSPVGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAAALCASERRCSPLCGLDLSKKSPPGSAAPERPLAERELPPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKLEEAAPPSDPFRGGSGSPGPEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDAAVSPGGPPLGLAPPPRYPGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT", "length": 733 }, "evidence": [ { "id": "F1ML16", "url": "https://omabrowser.org/oma/group/F1ML16/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" }, { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway in response to DNA damage", "id": "GO:0008630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008630", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" }, { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" }, { "name": "negative regulation of Wnt signaling pathway", "id": "GO:0030178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030178", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" }, { "name": "positive regulation of DNA damage response, signal transduction by p53 class mediator", "id": "GO:0043517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043517", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" }, { "name": "histone deacetylase binding", "id": "GO:0042826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042826", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" }, { "name": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "id": "GO:0001227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001227", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1ML16", "url": "https://www.uniprot.org/uniprotkb/F1ML16" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1ML16-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 868, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1ML16-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ML16" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1ML16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML16" }, { "id": "PS50097", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50097" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BTB", "eco_id": "ECO_0000259", "start_pos": 182, "end_pos": 245, "start_aa": "Cys", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1ML16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML16" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 572, "end_pos": 599, "start_aa": "Tyr", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 335 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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"field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MS13-1", "uniprot_ac": "F1MS13", "uniprot_id": "F1MS13_BOVIN", "mass": { "chemical_mass": 74827.0, "monoisotopic_mass": 74827.0 }, "refseq": { "ac": "XP_024830925", "name": "PHD finger protein 21A isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024830925" }, "gene_names": [ { "name": "PHF21A", "type": "recommended", "evidence": [ { "id": "F1MS13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS13" } ] }, { "name": 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"id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ANPLYNF", "url": "https://omabrowser.org/oma/group/ANPLYNF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1M959", "url": "https://www.orthodb.org/?gene=A0A3Q1M959", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MS13", "url": "https://www.orthodb.org/?gene=F1MS13", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24102", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24102", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24102:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24102:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00628", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00628", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3214815", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214815", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024830925", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024830925", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1M919", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M919", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M919-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M919-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M959", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M959", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M959-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M959-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS13", "url": "https://www.uniprot.org/uniprotkb/F1MS13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS13-1", "url": "https://www.uniprot.org/uniprotkb/F1MS13-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQPLQQLQQQQHHHHHAQAAASSPGLTAPQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGPGAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTVTPPAAPKPKREENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPPSSHPDSPENEKTETTFTFPASVQPVSLPSPTSTDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKQLSSSISKCMEMKNTILARQKEMHSSLEKVKQLIRLIHGIDLSKPVDSEATVGALSNGPDCTPPANASTSTPAPSPPSSSSQSCTANCNPGEETK", "length": 682, "header": "tr|F1MS13-1|F1MS13_BOVIN Isoform 1 of PHD finger protein 21A OS=Bos taurus OX=9913 GN=PHF21A PE=4 SV=2 CANONICAL=F1MS13-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M919-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M919/entry", "sequence": { "sequence": "MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQPLQQLQQQQHHHHHAQAAASSPGLTAPQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGPGAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTVTPPAAPKPKREENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRANEEHWPKGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKQLSSSISKCMEMKNTILARQKEMHSSLEKVKQLIRLIHGIDLSKPVDSEATVGALSNGPDCTPPANASTSTPAPSPPSSSSQSCTANCNPGEETK", "length": 635, "header": "tr|A0A3Q1M919-1|F1MS13_BOVIN Computationally mapped isoform of PHD finger protein 21A OS=Bos taurus OX=9913 GN=PHF21A PE=4 SV=1 CANONICAL=F1MS13-1" }, "locus": { "chromosome": "15", "start_pos": 76111946, "end_pos": 75961340, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068998.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068998.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066989.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066989.2" } ] } }, { "isoform_ac": "A0A3Q1M959-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M959/entry", "sequence": { "sequence": "MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQPLQQLQQQQHHHHHAQAAASSPGLTAPQTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGPGAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTVTPPAAPKPKREENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRANEEHWPKGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKQLSSSISLEKERFLEMSTGKMHGNEEHHPGPAEGDAQLPGEGKTADPPHPWHRPLQTCRL", "length": 599, "header": "tr|A0A3Q1M959-1|F1MS13_BOVIN Computationally mapped isoform of PHD finger protein 21A OS=Bos taurus OX=9913 GN=PHF21A PE=4 SV=2 CANONICAL=F1MS13-1" }, "locus": { "chromosome": "15", "start_pos": 76111946, "end_pos": 75961482, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000082725.2", "url": "https://www.ensembl.org/id/ENSBTAT00000082725.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066672.2", "url": "https://www.ensembl.org/id/ENSBTAP00000066672.2" } ] } }, { "isoform_ac": "F1MS13-1", "url": "https://www.uniprot.org/uniprotkb/F1MS13/entry", "sequence": { "sequence": "MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQPLQQLQQQQHHHHHAQAAASSPGLTAPQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGPGAEAVQIVAKNTVTLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTVTPPAAPKPKREENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPPSSHPDSPENEKTETTFTFPASVQPVSLPSPTSTDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKQLSSSISKCMEMKNTILARQKEMHSSLEKVKQLIRLIHGIDLSKPVDSEATVGALSNGPDCTPPANASTSTPAPSPPSSSSQSCTANCNPGEETK", "length": 682, "header": "tr|F1MS13-1|F1MS13_BOVIN Isoform 1 of PHD finger protein 21A OS=Bos taurus OX=9913 GN=PHF21A PE=4 SV=2 CANONICAL=F1MS13-1" }, "locus": { "chromosome": "15", "start_pos": 76111946, "end_pos": 75961340, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012652.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012652.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012652.5", "url": "https://www.ensembl.org/id/ENSBTAP00000012652.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 349, "start_aa": "Thr", "end_pos": 349, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr349", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 658, "start_aa": "Thr", "end_pos": 658, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr658", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-3214815", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3214815", "resource": "Reactome", "description": "HDACs deacetylate histones" }, { "id": "R-BTA-983231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "resource": "Reactome", "description": "Factors involved in megakaryocyte development and platelet production" } ], "orthologs": [ { "uniprot_canonical_ac": "Q96BD5-1", "protein_name": "PHD finger protein 21A", "gene_name": "PHF21A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLHELQAKITALSEKQKRVVEQLRKNLIVKQEQPDKFQIQPLPQSENKLQTAQQQPLQQLQQQQQYHHHHAQQSAAASPNLTASQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAINSQKAVLSTDVQNTPVNLQTSSKVTGPGAEAVQIVAKNTVTLVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKFTPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQTVKSHTETDEKQTESRTITPPAAPKPKREENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPQSSHPDSPENEKTETTFTFPAPVQPVSLPSPTSTDGDIHEDFCSVCRKSGQLLMCDTCSRVYHLDCLDPPLKTIPKGMWICPRCQDQMLKKEEAIPWPGTLAIVHSYIAYKAAKEEEKQKLLKWSSDLKQEREQLEQKVKQLSNSISKCMEMKNTILARQKEMHSSLEKVKQLIRLIHGIDLSKPVDSEATVGAISNGPDCTPPANAATSTPAPSPSSQSCTANCNQGEETK", "length": 680 }, "evidence": [ { "id": "F1MS13", "url": "https://omabrowser.org/oma/group/F1MS13/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MS13", "url": "https://www.uniprot.org/uniprotkb/F1MS13" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MS13", "url": "https://www.uniprot.org/uniprotkb/F1MS13" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "F1MS13", "url": "https://www.uniprot.org/uniprotkb/F1MS13" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MS13", "url": "https://www.uniprot.org/uniprotkb/F1MS13" } ], "pmid": "" }, { "name": "histone deacetylase complex", "id": "GO:0000118", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000118", "evidence": [ { "database": "UniProtKB", "id": "F1MS13", "url": "https://www.uniprot.org/uniprotkb/F1MS13" } ], "pmid": "" }, { "name": "DNA repair complex", "id": "GO:1990391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990391", "evidence": [ { "database": "UniProtKB", "id": "F1MS13", "url": "https://www.uniprot.org/uniprotkb/F1MS13" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MS13", "url": "https://www.uniprot.org/uniprotkb/F1MS13" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 417, "end_pos": 419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 653, "end_pos": 655, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MS13-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 682, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MS13-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MS13" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MS13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS13" }, { "id": "PS50016", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50016" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PHD-type", "eco_id": "ECO_0000259", "start_pos": 487, "end_pos": 534, "start_aa": "Glu", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 349, 658 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 417, "end_pos": 419 }, { "start_pos": 653, "end_pos": 655 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ 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"graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MLB9-1", "uniprot_ac": "F1MLB9", "uniprot_id": "F1MLB9_BOVIN", "mass": { "chemical_mass": 34752.0, "monoisotopic_mass": 34752.0 }, "refseq": { "ac": "NP_001068983", "name": "7-methylguanosine phosphate-specific 5'-nucleotidase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068983" }, "gene_names": [ { "name": "NT5C3B", "type": "recommended", "evidence": [ { "id": "F1MLB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB9" } ] }, { "name": "NT5C3B", "type": "synonym", "evidence": [ { "id": "NP_001068983", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068983" } ] }, { "name": "NT5C3L", "type": "synonym", "evidence": [ { "id": "NP_001068983", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068983" } ] } ], "protein_names": [ { "name": "5'-nucleotidase", "type": "recommended", "evidence": [ { "id": "F1MLB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB9/entry#names_and_taxonomy" } ] }, { "name": "3.1.3.5", "type": "synonym", "evidence": [ { "id": "F1MLB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB9/entry#names_and_taxonomy" } ] }, { "name": "5'-nucleotidase, cytosolic III-like", "type": "synonym", "evidence": [ { "id": "NP_001068983", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068983" } ] }, { "name": "7-methylguanosine phosphate-specific 5'-nucleotidase", "type": "synonym", "evidence": [ { "id": "NP_001068983", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068983" } ] } ], "function": [ { "annotation": "Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1M956", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M956#function" }, { "database": "UniProtKB", "id": "ARBA00046090", "url": "https://www.uniprot.org/uniprotkb/ARBA00046090#function" }, { "database": "UniProtKB", "id": "F1MLB9", "url": "https://www.uniprot.org/uniprotkb/F1MLB9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MLB9", "url": "https://www.uniprot.org/uniprotkb/F1MLB9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NT5C3B", "url": "https://www.uniprot.org/uniprotkb/F1MLB9", "locus": { "chromosome": "19", "start_pos": 42015644, "end_pos": 42024004, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011456", "url": "https://www.ensembl.org/id/ENSBTAG00000011456" } ] } } ], "crossref": [ { "id": "F1MLB9", "url": "https://alphafold.ebi.ac.uk/entry/F1MLB9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011456", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011456", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd07504", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07504", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511449", "url": "https://www.ncbi.nlm.nih.gov/gene/511449", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006434", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006434", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036412", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036412", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511449", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511449", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HIPWIYL", "url": "https://omabrowser.org/oma/group/HIPWIYL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MLB9", "url": "https://www.orthodb.org/?gene=F1MLB9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13045", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13045", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13045:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13045:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05822", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05822", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-429958", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-429958", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001068983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068983", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12484", "url": "https://www.rhea-db.org/rhea/12484", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "29367", "url": "https://www.rhea-db.org/rhea/29367", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "37107", "url": "https://www.rhea-db.org/rhea/37107", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1M956", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M956", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1M956-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M956-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLB9", "url": "https://www.uniprot.org/uniprotkb/F1MLB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLB9-1", "url": "https://www.uniprot.org/uniprotkb/F1MLB9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEEVSTLMKATVLMRQPGRVQEIVGALRKGGEDRLQVISDFDMTLSRFAYNGIRCPSSYNILDNSKIISEECRKELKALFHHYYPIEIDPHRTIKEKLPHMVEWWTKAHDLLCQQKIQKFQIAQVVRESNAMLRDGYKTFFNTLSQNNIPLFIFSAGIGDVLEEMIRQRKVFHPNIHIMSNYMEFDEDGFLNGFKGQLIHTYNKNSSVFENSNYFQQLQGKTNILLLGDSMGDLTMADGVPGVENILKIGFLNDKVEERRERYMDSYDIVLERDETLDVVNGLLQHILQQGDWTEMQGS", "length": 300, "header": "tr|F1MLB9-1|F1MLB9_BOVIN Isoform 1 of 5'-nucleotidase OS=Bos taurus OX=9913 GN=NT5C3B PE=3 SV=3 CANONICAL=F1MLB9-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1M956-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M956/entry", "sequence": { "sequence": "MAEEVISDFDMTLSRFAYNGIRCPSSYNILDNSKIISEECRKELKALFHHYYPIEIDPHRTIKEKLPHMVEWWTKAHDLLCQQKIQKFQIAQVVRESNAMLRDGYKTFFNTLSQNNIPLFIFSAGIGDVLEEMIRQRKVFHPNIHIMSNYMEFDEDVEERRERYMDSYDIVLERDETLDVVNGLLQHILQQGDWTEMQGS", "length": 200, "header": "tr|A0A3Q1M956-1|F1MLB9_BOVIN Computationally mapped isoform of 5'-nucleotidase OS=Bos taurus OX=9913 GN=NT5C3B PE=3 SV=1 CANONICAL=F1MLB9-1" }, "locus": { "chromosome": "19", "start_pos": 42023693, "end_pos": 42016019, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076832.2", "url": "https://www.ensembl.org/id/ENSBTAT00000076832.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070481.2", "url": "https://www.ensembl.org/id/ENSBTAP00000070481.2" } ] } }, { "isoform_ac": "F1MLB9-1", "url": "https://www.uniprot.org/uniprotkb/F1MLB9/entry", "sequence": { "sequence": "MAEEVSTLMKATVLMRQPGRVQEIVGALRKGGEDRLQVISDFDMTLSRFAYNGIRCPSSYNILDNSKIISEECRKELKALFHHYYPIEIDPHRTIKEKLPHMVEWWTKAHDLLCQQKIQKFQIAQVVRESNAMLRDGYKTFFNTLSQNNIPLFIFSAGIGDVLEEMIRQRKVFHPNIHIMSNYMEFDEDGFLNGFKGQLIHTYNKNSSVFENSNYFQQLQGKTNILLLGDSMGDLTMADGVPGVENILKIGFLNDKVEERRERYMDSYDIVLERDETLDVVNGLLQHILQQGDWTEMQGS", "length": 300, "header": "tr|F1MLB9-1|F1MLB9_BOVIN Isoform 1 of 5'-nucleotidase OS=Bos taurus OX=9913 GN=NT5C3B PE=3 SV=3 CANONICAL=F1MLB9-1" }, "locus": { "chromosome": "19", "start_pos": 42023693, "end_pos": 42016019, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015224.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015224.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015224.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015224.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:511449", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511449", "resource": "KEGG Pathway" }, { "id": "R-BTA-429958", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-429958", "resource": "Reactome", "description": "mRNA decay by 3' to 5' exoribonuclease" } ], "orthologs": [ { "uniprot_canonical_ac": "Q969T7-1", "protein_name": "7-methylguanosine phosphate-specific 5'-nucleotidase", "gene_name": "NT5C3B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEEVSTLMKATVLMRQPGRVQEIVGALRKGGGDRLQVISDFDMTLSRFAYNGKRCPSSYNILDNSKIISEECRKELTALLHHYYPIEIDPHRTVKEKLPHMVEWWTKAHNLLCQQKIQKFQIAQVVRESNAMLREGYKTFFNTLYHNNIPLFIFSAGIGDILEEIIRQMKVFHPNIHIVSNYMDFNEDGFLQGFKGQLIHTYNKNSSACENSGYFQQLEGKTNVILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYMDSYDIVLEKDETLDVVNGLLQHILCQGVQLEMQGP", "length": 300 }, "evidence": [ { "id": "F1MLB9", "url": "https://omabrowser.org/oma/group/F1MLB9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "F1MLB9", "url": "https://www.uniprot.org/uniprotkb/F1MLB9" } ], "pmid": "" }, { "name": "nucleotide binding", "id": "GO:0000166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000166", "evidence": [ { "database": "UniProtKB", "id": "F1MLB9", "url": "https://www.uniprot.org/uniprotkb/F1MLB9" } ], "pmid": "" }, { "name": "5'-nucleotidase activity", "id": "GO:0008253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008253", "evidence": [ { "database": "UniProtKB", "id": "F1MLB9", "url": "https://www.uniprot.org/uniprotkb/F1MLB9" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "F1MLB9", "url": "https://www.uniprot.org/uniprotkb/F1MLB9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MLB9", "url": "https://www.uniprot.org/uniprotkb/F1MLB9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "nucleotide metabolic process", "id": "GO:0009117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009117", "evidence": [ { "database": "UniProtKB", "id": "F1MLB9", "url": "https://www.uniprot.org/uniprotkb/F1MLB9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "12484", "name": "", "equation": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MLB9-1", "O46411-1", "A0A3Q1MCG3-1", "Q05927-1", "A0A3Q1MUV7-1", "A0AAA9TWP9-1", "A6H730-1" ], "evidence": [ { "id": "12484", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12484" } ] }, { "id": "29367", "name": "", "equation": "CMP + H2O = cytidine + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MLB9-1", "Q05927-1", "A0A3Q1MCG3-1" ], "evidence": [ { "id": "29367", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29367" } ] }, { "id": "37107", "name": "", "equation": "N(7)-methyl-GMP + H2O = N(7)-methylguanosine + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MLB9-1", "A0A3Q1MUV7-1", "A0AAA9TWP9-1" ], "evidence": [ { "id": "37107", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/37107" } ] }, { "id": "R-BTA-5694126", "name": "NT5C3B hydrolyses 7MGP to 7MG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-5694090" ], "enzyme_list": [ "F1MLB9-1" ], "evidence": [ { "id": "R-BTA-5694126", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5694126" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5694090", "participant_name": "7MG [cytosol]", "crossref": [ { "id": "HMDB0001107", "database": "HMDB Metabolite", "url": "" }, { "id": "20794", "database": "ChEBI", "url": "" }, { "id": "ZINC000018130229", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MCG3", "gene_name": "NT5E", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A0A3Q1MCG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCG3" } ] }, { "ec_number": "3.1.3.91", "activity": "N(7)-methyl-GMP + H2O = N(7)-methylguanosine + phosphate.", "evidence": [ { "id": "A0A3Q1MCG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCG3" } ] }, { "ec_number": "3.1.3.89", "activity": "a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate.", "evidence": [ { "id": "A0A3Q1MCG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCG3" } ] }, { "ec_number": "3.1.3.99", "activity": "IMP + H2O = inosine + phosphate.", "evidence": [ { "id": "A0A3Q1MCG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCG3" } ] }, { "ec_number": "3.1.3.35", "activity": "dTMP + H2O = thymidine + phosphate.", "evidence": [ { "id": "A0A3Q1MCG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCG3" } ] }, { "ec_number": "3.1.3.89", "activity": "", "evidence": [ { "id": "A0A3Q1MCG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCG3" } ] }, { "ec_number": "3.1.3.35", "activity": "", "evidence": [ { "id": "A0A3Q1MCG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCG3" } ] }, { "ec_number": "3.1.3.5", "activity": "", "evidence": [ { "id": "A0A3Q1MCG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCG3" } ] }, { "ec_number": "3.1.3.99", "activity": "", "evidence": [ { "id": "A0A3Q1MCG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCG3" } ] }, { "ec_number": "3.1.3.91", "activity": "", "evidence": [ { "id": "A0A3Q1MCG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MCG3" } ] } ] }, { "uniprot_ac": "A0A3Q1MUV7", "gene_name": "LOC534181", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A0A3Q1MUV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUV7" } ] }, { "ec_number": "3.1.3.5", "activity": "", "evidence": [ { "id": "A0A3Q1MUV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUV7" } ] } ] }, { "uniprot_ac": "A0AAA9TWP9", "gene_name": "NT5C3A", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A0AAA9TWP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWP9" } ] }, { "ec_number": "3.1.3.5", "activity": "", "evidence": [ { "id": "A0AAA9TWP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWP9" } ] } ] }, { "uniprot_ac": "A6H730", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.48", "activity": "O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A6H730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A6H730" } ] } ] }, { "uniprot_ac": "F1MLB9", "gene_name": "NT5C3B", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "F1MLB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB9" } ] }, { "ec_number": "3.1.3.5", "activity": "", "evidence": [ { "id": "F1MLB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB9" } ] } ] }, { "uniprot_ac": "O46411", "gene_name": "NT5C2", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "O46411", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46411" } ] }, { "ec_number": "2.7.1.77", "activity": "a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate = a ribonucleoside + a 2'-deoxyribonucleoside 5'-phosphate.", "evidence": [ { "id": "O46411", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46411" } ] }, { "ec_number": "3.1.3.99", "activity": "IMP + H2O = inosine + phosphate.", "evidence": [ { "id": "O46411", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46411" } ] }, { "ec_number": "3.1.3.99", "activity": "", "evidence": [ { "id": "O46411", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46411" } ] }, { "ec_number": "3.1.3.5", "activity": "", "evidence": [ { "id": "O46411", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46411" } ] }, { "ec_number": "2.7.1.77", "activity": "", "evidence": [ { "id": "O46411", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O46411" } ] } ] }, { "uniprot_ac": "Q05927", "gene_name": "NT5E", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "Q05927", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05927" } ] }, { "ec_number": "3.1.3.91", "activity": "N(7)-methyl-GMP + H2O = N(7)-methylguanosine + phosphate.", "evidence": [ { "id": "Q05927", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05927" } ] }, { "ec_number": "3.1.3.89", "activity": "a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate.", "evidence": [ { "id": "Q05927", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05927" } ] }, { "ec_number": "3.1.3.99", "activity": "IMP + H2O = inosine + phosphate.", "evidence": [ { "id": "Q05927", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05927" } ] }, { "ec_number": "3.1.3.35", "activity": "dTMP + H2O = thymidine + phosphate.", "evidence": [ { "id": "Q05927", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05927" } ] }, { "ec_number": "3.1.3.91", "activity": "", "evidence": [ { "id": "Q05927", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05927" } ] }, { "ec_number": "3.1.3.99", "activity": "", "evidence": [ { "id": "Q05927", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05927" } ] }, { "ec_number": "3.1.3.35", "activity": "", "evidence": [ { "id": "Q05927", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05927" } ] }, { "ec_number": "3.1.3.89", "activity": "", "evidence": [ { "id": "Q05927", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05927" } ] }, { "ec_number": "3.1.3.5", "activity": "", "evidence": [ { "id": "Q05927", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05927" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MLB9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 300, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MLB9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MLB9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.1.3.5", "ec_name": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "3.1.3.5", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5" }, { "id": "3.1.3.5", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.5" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 206, "end_pos": 208 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MNY2-1", "uniprot_ac": "F1MNY2", "uniprot_id": "F1MNY2_BOVIN", "mass": { "chemical_mass": 154613.0, "monoisotopic_mass": 154613.0 }, "refseq": { "ac": "NP_001179344", "name": "cell surface hyaluronidase CEMIP2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179344" }, "gene_names": [ { "name": "CEMIP2", "type": "recommended", "evidence": [ { "id": "F1MNY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNY2" } ] }, { "name": "BHLHB2", "type": "synonym", "evidence": [ { "id": "NP_001179344", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179344" } ] }, { "name": "CEMIP2", "type": "synonym", "evidence": [ { "id": "NP_001179344", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179344" } ] }, { "name": "TMEM2", "type": "synonym", "evidence": [ { "id": "NP_001179344", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179344" } ] } ], "protein_names": [ { "name": "hyaluronoglucosaminidase", "type": "recommended", "evidence": [ { "id": "F1MNY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNY2/entry#names_and_taxonomy" } ] }, { "name": "3.2.1.35", "type": "synonym", "evidence": [ { "id": "F1MNY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNY2/entry#names_and_taxonomy" } ] }, { "name": "basic helix-loop-helix domain containing, class B, 2", "type": "synonym", "evidence": [ { "id": "NP_001179344", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179344" } ] }, { "name": "cell surface hyaluronidase CEMIP2", "type": "synonym", "evidence": [ { "id": "NP_001179344", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179344" } ] }, { "name": "transmembrane protein 2", "type": "synonym", "evidence": [ { "id": "NP_001179344", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179344" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MNY2", "url": "https://www.uniprot.org/uniprotkb/F1MNY2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEMIP2", "url": "https://www.uniprot.org/uniprotkb/F1MNY2", "locus": { "chromosome": "8", "start_pos": 47923881, "end_pos": 48004836, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005090", "url": "https://www.ensembl.org/id/ENSBTAG00000005090" } ] } } ], "crossref": [ { "id": "ENSBTAG00000005090", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005090", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13938", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13938", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "515491", "url": "https://www.ncbi.nlm.nih.gov/gene/515491", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011050", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011050", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019316", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019316", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039473", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039473", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052252", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052252", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055400", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055400", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515491", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515491", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DYGCPRA", "url": "https://omabrowser.org/oma/group/DYGCPRA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MNY2", "url": "https://www.orthodb.org/?gene=F1MNY2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15535", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15535", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15535:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15535:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10162", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10162", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF15711", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15711", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24605", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24605", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24606", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24606", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179344", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAQ7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAQ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MAQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAQ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNY2", "url": "https://www.uniprot.org/uniprotkb/F1MNY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MNY2-1", "url": "https://www.uniprot.org/uniprotkb/F1MNY2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHATNSRGHSPAFLQPQNGNSHHSSGYVPGKVVPLRPPPPPKSQASAKFTSIRQEAQASFGFSSEEQQVQRERRKQKRHKNTFICFAITSFSFFVALAVILGISSKYAPDENCPDQNPRLRNWDPGQDSAKQVVIKEGDMFRLTSDATVNSIVIQDGGLLVFGDDKDGSRNITLRTHYILIKDGGALHIGAEKCRYKSKATIALYGKSDEGESMPTFGKKFIGVEAGGTLELHGTQKASWTLLVRTLNSSGLTFGSYAFKKDFSRGLNVRVIDQDTAKILEIERFDTHEFQNESRRLQKFLRDQDPGRIVAIAVGDSAVKSLLQGTIQMIQDRLGSKLIQGLGYRQAWALVGVIDGGSTSCNESVRNYENHSSGGKALAQREFYTVDGQKFSVTAYSEWKEGISFSGFWVEAIDGVKLHLLDDVSSWEPGDQIVVASTDYSMYQAEEFTLLPCPECSRFQVKVKETPQFLHMGEIIDGVDMRAEVGILTQNIVIRGEMEDSCYAENQCQFFDYDTFGGHVMIKKNFTSVHLSHVELKHMGQQHLGRYPVHFHLCGDVDYKGGYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTVGFDTLGHCFFLEDGIEQRNTLFHNLGLLTKPGTLLPTDRNNSMCITMREKVFGNYIPVPATDCMAVSTFWIAHPNNNLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNRVHSSFKAGLFIDKGVKTTNASAADPREYLCLDNSARFRPHQDGDPEKPRVAALIDRLIAFKNNDNGAWVRGGDIVVQNSAFADNGIGLTFASDGSFPSDEGSSQEVSESLFVGESRNYGFQGGQNKYVGTGGIDLKPRTLPRNRTFPIRGFQIYDGPIHLTRCTFQKYVPTLDRYTSAIGFLMKNSWQITPRNNISFVKFGPHVSLNVFFGKPGPWFEDCELDGDKNSIFHDIDGSVTGYKDAYVGRMDNYLIRHPSCINVTKWNAVVCSGSYAQVYVQTWSTPNLTMTITRDEYPDYPMVLRGINQKAAFSQYQPVIMLEKGYTIHWNGPAPKIAFLYLINFNKNDWIRVGLCYPSNTSFQVTFGFLQRHNGSLSKMEEYEPVHSLEELQKKQSERKFYFDSSTGLLFLYLKAKSHRDGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPRYYRKPSALKSMPSMLKGLCQGCGTRQVVFTSDPHISYLPVQFRSPSQAEIQRGDASVISINGTDFPLRSVGVLLLIVDACSVPFRLTEKKIFSFTDVSRMEEYLKTSIPPRSVVLLSTRGQIKQFNISDSLVPLGLAKPANLYNKGSTIFLGFNGNFKPSWTKLYTSPARQGLGLLEQFIPLQLDEYGCHRADTIRRRDLELLKQTSKAH", "length": 1383, "header": "tr|F1MNY2-1|F1MNY2_BOVIN Isoform 1 of hyaluronoglucosaminidase OS=Bos taurus OX=9913 GN=CEMIP2 PE=3 SV=2 CANONICAL=F1MNY2-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MAQ7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MAQ7/entry", "sequence": { "sequence": "MHATNSRGHSPAFLQPQNGNSHHSSGYVPGKVVPLRPPPPPKSQASAKFTSIRQEAQASFGFSSEEQQVQRERRKQKRHKNTFICFAITSFSFFVALAVILGISSKYAPDENCPDQNPRLRNWDPGQDSAKQVVIKEGDMFRLTSDATVNSIVIQDGGLLVFGDDKDGSRNITLRTHYILIKDGGALHIGAEKCRYKSKATIALYGKSDEGESMPTFGKKFIGVEAGGTLELHGTQKASWTLLVRTLNSSGLTFGSYAFKKDFSRGLNVRVIDQDTAKILEIERFDTHEFQNESRRLQKFLRDQDPGRIVAIAVGDSAVKSLLQGTIQMIQDRLGSKLIQGLGYRQAWALVGVIDGGSTSCNESVRNYENHSSGGKALAQREFYTVDGQKFSVTAYSEWKEETPQFLHMGEIIDGVDMRAEVGILTQNIVIRGEMEDSCYAENQCQFFDYDTFGGHVMIKKNFTSVHLSHVELKHMGQQHLGRYPVHFHLCGDVDYKGGYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTVGFDTLGHCFFLEDGIEQRNTLFHNLGLLTKPGTLLPTDRNNSMCITMREKVFGNYIPVPATDCMAVSTFWIAHPNNNLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNRVHSSFKAGLFIDKGVKTTNASAADPREYLCLDNSARFRPHQDGDPEKPRVAALIDRLIAFKNNDNGAWVRGGDIVVQNSAFADNGIGLTFASDGSFPSDEGSSQEVSESLFVGESRNYGFQGGQNKYVGTGGIDLKPRTLPRNRTFPIRGFQIYDGPIHLTRCTFQKYVPTLDRYTSAIGFLMKNSWQITPRNNISFVKFGPHVSLNVFFGKPGPWFEDCELDGDKNSIFHDIDGSVTGYKDAYVGRMDNYLIRHPSCINVTKWNAVVCSGSYAQVYVQTWSTPNLTMTITRDEYPDYPMVLRGINQKAAFSQYQPVIMLEKGYTIHWNGPAPKIAFLYLINFNKNDWIRVGLCYPSNTSFQVTFGFLQRHNGSLSKMEEYEPVHSLEELQKKQSERKFYFDSSTGLLFLYLKAKSHRDGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPRYYRKPSALKSMPSMLKGLCQGCGTRQVVFTSDPHISYLPVQFRSPSQAEIQRGDASVISINGTDFPLRSVGVLLLIVDACSVPFRLTEKKIFSFTDVSRMEEYLKTSIPPRSVVLLSTRGQIKQFNISDSLVPLGLAKPANLYNKGSTIFLGFNGNFKPSWTKLYTSPARQGLGLLEQFIPLQLDEYGCHRADTIRRRDLELLKQTSKAH", "length": 1320, "header": "tr|A0A3Q1MAQ7-1|F1MNY2_BOVIN Computationally mapped isoform of hyaluronoglucosaminidase OS=Bos taurus OX=9913 GN=CEMIP2 PE=3 SV=1 CANONICAL=F1MNY2-1" }, "locus": { "chromosome": "8", "start_pos": 47987251, "end_pos": 47925683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000077502.2", "url": "https://www.ensembl.org/id/ENSBTAT00000077502.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000067320.2", "url": "https://www.ensembl.org/id/ENSBTAP00000067320.2" } ] } }, { "isoform_ac": "A0AAA9SL89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL89/entry", "sequence": { "sequence": "MHATNSRGHSPAFLQPQNGNSHHSSGYVPGKVVPLRPPPPPKSQASAKFTSIRQEAQASFGFSSEEQQVQRERRKQKRHKNTFICFAITSFSFFVALAVILGISSKYAPDENCPDQNPRLRNWDPGQDSAKQVVIKEGDMFRLTSDATVNSIVIQDGGLLVFGDDKDGSRNITLRTHYILIKDGGALHIGAEKCRYKSKATIALYGKSDEGESMPTFGKKFIGVEAGGTLELHGTQKASWTLLVRTLNSSGLTFGSYAFKKDFSRGLNVRVIDQDTAKILEIERFDTHEFQNESRRLQKFLRDQDPGRIVAIAVGDSAVKSLLQGTIQMIQDRLGSKLIQGLGYRQAWALVGVIDGGSTSCNESVRNYENHSSGGKALAQREFYTVDGQKFSVTAYSEWKEGISFSGFWVEAIDGVKLHLLDDVSSWEPGDQIVVASTDYSMYQAEEFTLLPCPECSRFQVKVKETPQFLHMGEIIDGVDMRAEVGILTQNIVIRGEMEDSCYAENQCQFFDYDTFGGHVMIKKNFTSVHLSHVELKHMGQQHLGRYPVHFHLCGDVDYKGGYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTVGFDTLGHCFFLEDGIEQRNTLFHNLGLLTKPGTLLPTDRNNSMCITMREKVFGNYIPVPATDCMAVSTFWIAHPNNNLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNRVHSSFKAGLFIDKGVKTTNASAADPREYLCLDNSARFRPHQDGDPEKPRVAALIDRLIAFKNNDNGAWVRGGDIVVQNSAFADNGIGLTFASDGSFPSDEGSSQEVSESLFVGESRNYGFQGGQNKYVGTGGIDLKPRTLPRNRTFPIRGFQIYDGPIHLTRCTFQKYVPTLDRYTSAIGFLMKNSWQITPRNNISFVKFGPHVSLNVFFGKPGPWFEDCELDGDKNSIFHDIDGSVTGYKDAYVGRMDNYLIRHPSCINVTKWNAVVCSGSYAQVYVQTWSTPNLTMTITRDEYPDYPMVLRGINQKAAFSQYQPVIMLEKGYTIHWNGPAPKIAFLYLINFNKNDWIRVGLCYPSNTSFQVTFGFLQRHNGSLSKMEEYEPVHSLEELQKKQSERKFYFDSSTGLLFLYLKAKSHRDGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPRYYRKPSALKSMPSMLKGLCQGCGTRQVVFTSDPHISYLPVQFRSPSQAEIQRGDASVISVSCPVEHKRTDKAVQYFGFISTSGISQASQSL", "length": 1264, "header": "tr|A0AAA9SL89-1|F1MNY2_BOVIN Computationally mapped isoform of hyaluronoglucosaminidase OS=Bos taurus OX=9913 GN=CEMIP2 PE=3 SV=1 CANONICAL=F1MNY2-1" }, "locus": { "chromosome": "8", "start_pos": 47987251, "end_pos": 47926223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000109988.1", "url": "https://www.ensembl.org/id/ENSBTAT00000109988.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087140.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087140.1" } ] } }, { "isoform_ac": "F1MNY2-1", "url": "https://www.uniprot.org/uniprotkb/F1MNY2/entry", "sequence": { "sequence": "MHATNSRGHSPAFLQPQNGNSHHSSGYVPGKVVPLRPPPPPKSQASAKFTSIRQEAQASFGFSSEEQQVQRERRKQKRHKNTFICFAITSFSFFVALAVILGISSKYAPDENCPDQNPRLRNWDPGQDSAKQVVIKEGDMFRLTSDATVNSIVIQDGGLLVFGDDKDGSRNITLRTHYILIKDGGALHIGAEKCRYKSKATIALYGKSDEGESMPTFGKKFIGVEAGGTLELHGTQKASWTLLVRTLNSSGLTFGSYAFKKDFSRGLNVRVIDQDTAKILEIERFDTHEFQNESRRLQKFLRDQDPGRIVAIAVGDSAVKSLLQGTIQMIQDRLGSKLIQGLGYRQAWALVGVIDGGSTSCNESVRNYENHSSGGKALAQREFYTVDGQKFSVTAYSEWKEGISFSGFWVEAIDGVKLHLLDDVSSWEPGDQIVVASTDYSMYQAEEFTLLPCPECSRFQVKVKETPQFLHMGEIIDGVDMRAEVGILTQNIVIRGEMEDSCYAENQCQFFDYDTFGGHVMIKKNFTSVHLSHVELKHMGQQHLGRYPVHFHLCGDVDYKGGYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTVGFDTLGHCFFLEDGIEQRNTLFHNLGLLTKPGTLLPTDRNNSMCITMREKVFGNYIPVPATDCMAVSTFWIAHPNNNLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNRVHSSFKAGLFIDKGVKTTNASAADPREYLCLDNSARFRPHQDGDPEKPRVAALIDRLIAFKNNDNGAWVRGGDIVVQNSAFADNGIGLTFASDGSFPSDEGSSQEVSESLFVGESRNYGFQGGQNKYVGTGGIDLKPRTLPRNRTFPIRGFQIYDGPIHLTRCTFQKYVPTLDRYTSAIGFLMKNSWQITPRNNISFVKFGPHVSLNVFFGKPGPWFEDCELDGDKNSIFHDIDGSVTGYKDAYVGRMDNYLIRHPSCINVTKWNAVVCSGSYAQVYVQTWSTPNLTMTITRDEYPDYPMVLRGINQKAAFSQYQPVIMLEKGYTIHWNGPAPKIAFLYLINFNKNDWIRVGLCYPSNTSFQVTFGFLQRHNGSLSKMEEYEPVHSLEELQKKQSERKFYFDSSTGLLFLYLKAKSHRDGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPRYYRKPSALKSMPSMLKGLCQGCGTRQVVFTSDPHISYLPVQFRSPSQAEIQRGDASVISINGTDFPLRSVGVLLLIVDACSVPFRLTEKKIFSFTDVSRMEEYLKTSIPPRSVVLLSTRGQIKQFNISDSLVPLGLAKPANLYNKGSTIFLGFNGNFKPSWTKLYTSPARQGLGLLEQFIPLQLDEYGCHRADTIRRRDLELLKQTSKAH", "length": 1383, "header": "tr|F1MNY2-1|F1MNY2_BOVIN Isoform 1 of hyaluronoglucosaminidase OS=Bos taurus OX=9913 GN=CEMIP2 PE=3 SV=2 CANONICAL=F1MNY2-1" }, "locus": { "chromosome": "8", "start_pos": 47987251, "end_pos": 47925683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006709.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006709.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006709.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006709.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:515491", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515491", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JZA7-1", "protein_name": "hyaluronoglucosaminidase", "gene_name": "Cemip2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYAAGSRGHSPAFLQPQNGNGHRSPGYVPGKVVPFRPAPPPKNHASAKLTSRSQEAPATFAFSPEEQRTPREDRKQKRHKNTFICFAITSFSFFVTLAVILGISSKYAPDENCPDQNPRLRNWDPGQDSAKHIVIKEGDMLRLTSDATVNSIVIQDGGLLVFGDDKDGSRNITLRTRYILIQDGGALHIGAEKCRYRSKATITLYGKSDEHESMPTFGKKFIGVEAGGTLELHGARRTSWTMLARTLHSSGLPFGSYAFEKDFSRGLNVRVIDQDTARVLEHEKFDTHEYHNESRRLQEFLRAQDPGRIVAIAVGDSAVKSLLQGTIQMIQDRLGSKLIQGLGYRQAWALVGVIDGGSSSCNESVRNYENHSTGGKALAQGEFYTLDGQKFSVTAYSEWIEGISLSGFRVDIADGVKLHLLDDVSSWGAGDRIVVASTDYSMYQAEELTLLPCPECSRFQVKVKEIPQYLHVGEIIDGIDMRAEVGLLTRNIVIQGETEDSCYADNHCQFFDYDTFGGHVMIEKNFTSVHLSYVELKHMGQQHLGRYPVHFHLCGDVDSKGGYRVPTSVNGLSIHHSFSRCITVHGSSGLLIKDTIGFDTLGHCFFLEDGVEQRNILFHNLGLLTKPGTLLPTDRNSSMCTVMRDGVFGNYIPVPTTDCMAVSTFWIAHPNNHLINNAAAGSQDAGIWYLFHKEPTGESSGMQLLEKPELTPLGIFYNNRVHSNFKAGLFVDKGVKTTNSSASDPREYLCLDNSARFRPHQDADPEKPRVAAVIDRLIAFKNNDNGAWVRGGDIIVQNSAFADNGKGLTFASDGSFPSDEGSSQEVSESLFVGESKNYGSQGGQNKYMGTGGIDQKPRTLPRNRTFPIRGFQIYDGPIHLTKSTFKKYVPTPDRYSSAIGFLMKNSWQTTPRNNVSLVKFGPQVSLNVFFGKPGPWFEDCELDGDKNSIFHDIDGSVTGYKDTYVGRMDNYLIRHPNCVSVTKWNAVVCSGTYAQVYVQTWNTPNLSMIITRDEYPSHPMVLRGINQRAISPQYQPVVMLEKGYTIHWSGPAPRTTFLYLVNFNKDDWIRVGLCYPSNTSFQVTVGFLQRQNGSLSRIEEYEPAQSMEELQKKPSERKFYFDSGTGLLFLYLRAHSHRDGHSYCSSQGCERVKIQAATDSKDMSNCMAKAYPQYYKKPSAVKRMPAMLTGFCQGCGTHQMVFSSDPHKSYLPVRFQSPGKAEIQRGEPSVISVNGTDFTFRSAGAFLLIVDACSVPFRLTEKRMFLSADISHLEEYLKASIPPRSIVLLSTRGEIKQMNISDSFVLLGLAKPAHLYNKGSTVFLGFSGNFTPSWTRLFTSPDVQGLGVLEQYLPLQMEEYGCSRTSSVHRRDLELLQQALKGL", "length": 1383 }, "evidence": [ { "id": "F1MNY2", "url": "https://omabrowser.org/oma/group/F1MNY2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NJD8-1", "protein_name": "hyaluronoglucosaminidase", "gene_name": "CEMIP2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MQDTDARGSSPAFLPPQNGSSHRSSGYVPGRIAPLRPPPPSQSHVSAEFTSARQEARAMFASSPPGQHRRHAEANRHKNTLICFAVSSFSLFVALGIFMGIASKYAPDENCPDQNPRLKNWSPGKDPEKKVLIKKGDLFRLNSDATVHSITIQDGGLLVFGDDKDGSKNITLRTRFILIKDGGMLHVGAEKCRYKSKATIILYGKSNEDADVPEFGKKFIGVGPEGTLELHGHQKLSWTLLSKSVNFSGLACGHYAFKKNFSRGLNVRVIDQDTASVLEVLKFDTHEFSEESLKLQNLLKNRSPGRIIAIAVGDSAAKNLLEETRVTIQNLLGSKFVRGLSYRQAWALVGVIGGGNSSCNESVRDYENHSTGGKALAQKEFFTVDGQKFVVRAFSEWNDGVPISGFQVEPVGGVILNLLDDVSSWEPGDRIVVASTDYSMYQTEEFTVLPCPECTKHQVKVKEKPQYPHVGEVIDGVDMRAEVGVLTRNILIKGETENTCYREKECQFFNYDTFGGHIKILKNFTSVHLSYVELKQMGQQQIGSYPVHFHLCGDVDEKGGYSSKTYLDGLSIHHCFSRCVTIHATNGLLIKDTIGYDTLGHCFFIEDGIEQRNTLFHNLGLVTKPGTILPTDRNSTMCTGIRDKVYGSYVPVPATDCMAVSTFWISHPNNHLISNAAAGSQDAGIWYLFHKIATGDSHSLGIETKSELTPLGIFYNNRVHSNFKAGLFIDKGVKTTNASADDPREYLCLDNNARFRPHQDADPEKPRVAALIDGLISFKNNDHGAWVRGGDILIQNSGFADNGIGLTFASDGSFPNDEGASQVVSESLFIGESKNYGFHGGQNKYTGSGGIDNKVRTLPRNRTFPIRGFQIYDGPIHLTKCTFRNFVPTPDRFTSAIGFLMKNPWQMTPRNNISLVKFGPNVSLKAFFGKPGPWFEEVDLDGDKNSIFHDLDGSVTGYKDTYVGRMDNYLIQHPKCINNTEWNGVICSGTYAQVYVQTWNGQNLSMTIVRDEYPSNPMVLKGINQRAVFQQYQPVVMLQKGYTIHWNGKAPNVTYLYLINFNKNDWIRVGLCYQPNTDFTIVLETFQRKSSALSSKVERYTPVSSMLELEKNRSDKKFYFDNSTGLLFLFLQAKYNRDGHSYCSSQGCERIKIVTKDSAKGVSNCMAKAYPKYYQGPAVIKQMPVKTTVPCTKCGTTQMVFTSDPHKNYLLVQINLSGKNELSGSQQAFISVNNTMFSFKDNGILVVVVDACTGTVSGNHLFSGVDIKRVGGYLMSGIPQRSVVLLSTRGKVEIPNNLSDALKCLGTAKPPYLQSNGSVAFLGFRGNFKPSWVKLFTSPSGHELIQIEKYIPLQLEEYGCTRAIKSRRKDLDLLKKATRSH", "length": 1381 }, "evidence": [ { "id": "F1MNY2", "url": "https://omabrowser.org/oma/group/F1MNY2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q54KF6-1", "protein_name": "Protein DDB_G0287365", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MMSFNLILILIIFLILIQNYVIDGNDNFNLIKCPDEIPNLKKWSNYKSWKKLKLPIKGESINITTPILMDIKPPDLDVIRIFDKGMLVWKHINNLELRVKAILIYDGGQLIIGSEQCKFKYKATITLIGDSIYTEINQTINGNEYGQKVIGIDNGGTIELHSEVTKTTWTKLISTISPSTFNSNKNILTLLDNVNDWPIGSEILITSTDYDMEQSETNFIVKCSTCKTNQIKLKNPIKYLHWGSITKGVDERAEVALLTRNIKIQGQVGKTCVNNKLVCDFFPFDSFGAHIMIRKGFVNAHFFGIELFNVGQSHVVSRYPIHFHLCDRVDELGGYENPAYIKHCSVHKSFSRCYVVHSTDGLLIHDNIGFDSIGHCYMLCDGIEMDNVFSHNLGAVTRYGLLFPHDRSCDMCSRIQPNDFNGNPTQCTECNAVSTFWISNPWNTLIDNVASGSDSTGIWYLFSDYPSGLSHERGIKYNIKPYLIPVKKFYNNNVHSCTNGIQIDGGVKLTPPSKTQPQQLNSMINARYKPRSNPKNPNSKPSPSIFNGATIYKNKWRGCWARGGFLFMKNFKIADNAIGFTFASEGTIPGDQNVGQYIYKSLIVGESDNIGQQSNNIPIVNGRTNPYGENGLMPIRGFEIYDGTISLDSMVFSEFKSLPPLFRNSSAIGFLRFNDWQSSSETTIKNIKYINVDKEIHFEQSLMDGDKISTLRDLDGSTTKLSNSILVRNLLFYSTNNCYYKKPWDALICKEDTRQIYICNDDTNSTNYLSLSSSVVAIRDNIENQKIEQIGLPNHSPRNRFQFLVFKNHHYDFHFPNHPTPPILRVQPMNWKQSEKFTFGICIGISKGINLKVLKTVNGTYGNSNFVEELYPTFSMNLISESTYYFNEITSMLYIMYYQYNSKDHLNYCPEYGCEELVIKISGKNSGRVTGDCQSLAYGSSFTLFDEVVNRKFENSFQMDKSIIHNSEYAYRGNAYLPYHPTSKSQIQFKCNHCIPSVGIKYFEIWVNGNRNSNQRISIQLFYSINSNQLKSQPFAIDKNYFKKNSWVLVRILFENLKNLLPENHIHLISSFDGLSIINSLELNQPSLFLDNIKFIYDN", "length": 1099 }, "evidence": [ { "id": "F1MNY2", "url": "https://omabrowser.org/oma/group/F1MNY2/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5FWI3-1", "protein_name": "Cell surface hyaluronidase", "gene_name": "Cemip2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYAAGSRGHSPAFLQPQNGNGHRSPGYVPGKVVPLRPAPPPKNHASAKLTSRSQDAPATFAFSPEEQRTPSESRKRKRHKNTFICFAITSFSFFVALAVILGISSKYAPDENCPDQNPRLRNWDPGQDSAKHIVIKEGDLFRLTSDATVDSIVIQDGGLLVFGDDKDGSKNITLRTRYILIQDGGALHIGAEKCRYRSKATITLYGKSDERESMPIFGKKFIGVEAGGTLELHGAQRTSWTMLARTLHSSGLPFGSYAFEKDFSRGLNVRVIDQDTARVLENEKFDTHEYHNESRRLQEFLRAQEPGRIVAIAVGDSAVKSLLQGTIQMIQDRLGSKLIQGLGYRQAWALVGVIDGGSSSCNESVRNYENHSTGGKALAQGEFYTLDGQKFSVTAYSEWSQGISLSGFRVDIADGVKLHLLDDVSTWEAGDRIVVASTDYSMYQAEELTLLRCPECSRSQVKVKEIPQYLHVGEIIDGIDMRAEVGLLTRNIVIQGEMEDSCYAENHCQFFDYDTFGGHVMIEKNFTSVHLSYVELKHMGQQHMGRYPVHFHLCGDVDSKGGYSQPASVDGLSVHHSFSRCITVHGTSGLLIKDTIGFDTLGHCFFLEDGVEQRNILYHNLGLLTKPGTLLPTDRNSSMCTVMRDGVFGNYVPVPTTDCMAVSTFWIAHPNNHLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLEKPELTPLGIFYNNRVHSNFKAGLFVDKGVKTTNASASDPREYLCLDNSARFRPHQDADPEKPRVAAIIDRLIAFKNNDNGAWVRGGDIIVQNSAFADNGKGLTFASDGSFPSDEGSSQEVTESLFVGESRNYGFQGGQNKYMGTGGIDQKPRTLPRNRTFPIRGFQIYDGPIHLTKSTFKKYVPTPDRYSSAIGFLMKNSWQTTPRNNVSLVKFGPQVSLNVFFGKPGPWFEDCELDGDKNSIFHDIDGSVTGYKDTYVGRMDNYLIRHPNCVNVTKWNAVICSGTYAQVYVQTWNTPNLSMIITRDEYPSHPMVLRGINQRAISPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKDDWIRVGLCYPANTSFQVTVGFLQRQNGSLSRIEDYEPARSMEELQKKPSERKFYFDSGTGLLFLYLRAHSHRDGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYKKPSAVKRMPAMLTGLCQGCGTHQMVFTSDPHKSYLPVRFQSPGKAEIQRGDPSIISVNGTDFTFRSAGALLLIVDACSVPFRVKEKRMFLSADVSHMEEYFKASIPPRSIVLLSTRGEIKQLNISDSLAVLGLAKPAHLYSKGSVVFLGFSGNFAPSWTKLFTSPDEQGLGVLEQFLPLQMEEYGCSRTGSVHRRDLDLLQQALKVL", "length": 1383 }, "evidence": [ { "id": "F1MNY2", "url": "https://omabrowser.org/oma/group/F1MNY2/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UHN6-1", "protein_name": "Cell surface hyaluronidase CEMIP2", "gene_name": "CEMIP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MYATDSRGHSPAFLQPQNGNSRHPSGYVPGKVVPLRPPPPPKSQASAKFTSIRREDRATFAFSPEEQQAQRESQKQKRHKNTFICFAITSFSFFIALAIILGISSKYAPDENCPDQNPRLRNWDPGQDSAKQVVIKEGDMLRLTSDATVHSIVIQDGGLLVFGDNKDGSRNITLRTHYILIQDGGALHIGAEKCRYKSKATITLYGKSDEGESMPTFGKKFIGVEAGGTLELHGARKASWTLLARTLNSSGLPFGSYTFEKDFSRGLNVRVIDQDTAKILESERFDTHEYRNESRRLQEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQERLGSELIQGLGYRQAWALVGVIDGGSTSCNESVRNYENHSSGGKALAQREFYTVDGQKFSVTAYSEWIEGVSLSGFRVEVVDGVKLNLLDDVSSWKPGDQIVVASTDYSMYQAEEFTLLPCSECSHFQVKVKETPQFLHMGEIIDGVDMRAEVGILTRNIVIQGEVEDSCYAENQCQFFDYDTFGGHIMIMKNFTSVHLSYVELKHMGQQQMGRYPVHFHLCGDVDYKGGYRHATFVDGLSIHHSFSRCITVHGTNGLLIKDTIGFDTLGHCFFLEDGIEQRNTLFHNLGLLTKPGTLLPTDRNNSMCTTMRDKVFGNYIPVPATDCMAVSTFWIAHPNNNLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNRVHSNFKAGLFIDKGVKTTNSSAADPREYLCLDNSARFRPHQDANPEKPRVAALIDRLIAFKNNDNGAWVRGGDIIVQNSAFADNGIGLTFASDGSFPSDEGSSQEVSESLFVGESRNYGFQGGQNKYVGTGGIDQKPRTLPRNRTFPIRGFQIYDGPIHLTRSTFKKYVPTPDRYSSAIGFLMKNSWQITPRNNISLVKFGPHVSLNVFFGKPGPWFEDCEMDGDKNSIFHDIDGSVTGYKDAYVGRMDNYLIRHPSCVNVSKWNAVICSGTYAQVYVQTWSTQNLSMTITRDEYPSNPMVLRGINQKAAFPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCYPSNTSFQVTFGYLQRQNGSLSKIEEYEPVHSLEELQRKQSERKFYFDSSTGLLFLYLKAKSHRHGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYRKPSVVKRMPAMLTGLCQGCGTRQVVFTSDPHKSYLPVQFQSPDKAETQRGDPSVISVNGTDFTFRSAGVLLLVVDPCSVPFRLTEKTVFPLADVSRIEEYLKTGIPPRSIVLLSTRGEIKQLNISHLLVPLGLAKPAHLYDKGSTIFLGFSGNFKPSWTKLFTSPAGQGLGVLEQFIPLQLDEYGCPRATTVRRRDLELLKQASKAH", "length": 1383 }, "evidence": [ { "id": "F1MNY2", "url": "https://omabrowser.org/oma/group/F1MNY2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MNY2", "url": "https://www.uniprot.org/uniprotkb/F1MNY2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "F1MNY2", "url": "https://www.uniprot.org/uniprotkb/F1MNY2" } ], "pmid": "" }, { "name": "hyalurononglucosaminidase activity", "id": "GO:0004415", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004415", "evidence": [ { "database": "UniProtKB", "id": "F1MNY2", "url": "https://www.uniprot.org/uniprotkb/F1MNY2" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MNY2", "url": "https://www.uniprot.org/uniprotkb/F1MNY2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "hyaluronan catabolic process", "id": "GO:0030214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030214", "evidence": [ { "database": "UniProtKB", "id": "F1MNY2", "url": "https://www.uniprot.org/uniprotkb/F1MNY2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1005, "end_pos": 1007, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1078, "end_pos": 1080, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1092, "end_pos": 1094, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1234, "end_pos": 1236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1299, "end_pos": 1301, "annotation": "n_glycosylation_sequon" }, { "start_pos": 171, "end_pos": 173, "annotation": "n_glycosylation_sequon" }, { "start_pos": 248, "end_pos": 250, "annotation": "n_glycosylation_sequon" }, { "start_pos": 292, "end_pos": 294, "annotation": "n_glycosylation_sequon" }, { "start_pos": 362, "end_pos": 364, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 525, "end_pos": 527, "annotation": "n_glycosylation_sequon" }, { "start_pos": 636, "end_pos": 638, "annotation": "n_glycosylation_sequon" }, { "start_pos": 739, "end_pos": 741, "annotation": "n_glycosylation_sequon" }, { "start_pos": 863, "end_pos": 865, "annotation": "n_glycosylation_sequon" }, { "start_pos": 914, "end_pos": 916, "annotation": "n_glycosylation_sequon" }, { "start_pos": 980, "end_pos": 982, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MNY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNY2" }, { "id": "PS51484", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51484" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G8", "eco_id": "ECO_0000259", "start_pos": 121, "end_pos": 245, "start_aa": "Arg", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.2.1.35", "ec_name": "Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.", "evidence": [ { "id": "3.2.1.35", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.35" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1005, "end_pos": 1007 }, { "start_pos": 1078, "end_pos": 1080 }, { "start_pos": 1092, "end_pos": 1094 }, { "start_pos": 1234, "end_pos": 1236 }, { "start_pos": 1299, "end_pos": 1301 }, { "start_pos": 171, "end_pos": 173 }, { "start_pos": 248, "end_pos": 250 }, { "start_pos": 292, "end_pos": 294 }, { "start_pos": 362, "end_pos": 364 }, { "start_pos": 370, "end_pos": 372 }, { "start_pos": 525, "end_pos": 527 }, { "start_pos": 636, "end_pos": 638 }, { "start_pos": 739, "end_pos": 741 }, { "start_pos": 863, "end_pos": 865 }, { "start_pos": 914, "end_pos": 916 }, { "start_pos": 980, "end_pos": 982 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MLZ4-1", "uniprot_ac": "F1MLZ4", "uniprot_id": "F1MLZ4_BOVIN", "mass": { "chemical_mass": 434237.0, "monoisotopic_mass": 434237.0 }, "refseq": {}, "gene_names": [ { "name": "LYST", "type": "recommended", "evidence": [ { "id": "F1MLZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" } ] } ], "protein_names": [ { "name": "Lysosomal-trafficking regulator", "type": "recommended", "evidence": [ { "id": "F1MLZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MLZ4", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LYST", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4", "locus": { "chromosome": "28", "start_pos": 8379173, "end_pos": 8548559, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016804", "url": "https://www.ensembl.org/id/ENSBTAG00000016804" } ] } } ], "crossref": [ { "id": "ENSBTAG00000016804", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016804", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06071", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06071", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023362", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023362", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MLZ4", "url": "https://www.orthodb.org/?gene=F1MLZ4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13743", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13743", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13743:SF86", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13743:SF86", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02138", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02138", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14844", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14844", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1MD56", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MD56-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLS8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SLS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYN1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLZ4", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLZ4-1", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQEEKATDFNLPFSAGIILTKEKNSSSQRSTQEKLYLEGSAPAGQVSAKVNVFRKSRRQRKTTHRYSVRDARKTQLSTSDSEVNSDDKSIVMTKYRRSHVLQHFVKQCPKEDHLTAKLNHLSTKEQTPPDTMALENSREIIPREESNTDILSEPAALSTISHMNNSPFDLCHVLLSLLEKVCKFDITLNHNSALAASVVPTLTEFLAGFGDCCNLSDNLEGQMVSAGWTEEPVALIQRMLFRTVLHLMSVDISMAEVMPENLRKNLTELLRAALKIRTFLEKQPDPFAPRQKKTLQEVQDDFVFSKYCHRVLLLPELLEGVLQILICCLQSAASNPFFFSQAMDLVQEFIQHHGFHLFETAVLQMEWLVVRDGVPPEASGHLKALINNVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGDVYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVQNIGICCCMDPKSVIVPLLHAFKLPALKSCQQHILNILNKLILDQLGGAEIPQKTKKAACNICTVDSDQLAKLEETLQGSSYNAEPSSGLSSPSYRFQGILPSSGSEDLLWKWDALEAYQNFVFEEDRLQSVQIANHICSLIQKGNVVVQWKLYNCIFNPVLQRGVELAHHCQQLSISSAQTHVCSHHNQCLPQEVLQIYLKTLPTLLKSRVIRDLFLSCNGVNQIIELNYLDGIRNHSLKAFETLIISLGEQQKDSSIPGIDGIDLEQKELSSLNVGTLYNQQAYSDSQSLSKFYARLKDAYPKKRKSVVQDIHISTINLFLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLQHMLPCFSLESLVLPSPRHMHQAADVWSMCRWIYMLSPIFRKQFYRLGGFQVCHKLIFMVIQDLFRNPEEEQGRKEGDRTMNENQDLNRISQPEITVKEDLLSLTVKIDPTPTELSSLKKSADSLGKLESEHLSSINVEQIPAVEAVPEETKVFMSRESETLLQGIRLLEALLAICLHGTRASQQKLELELPNQNLSVETILLEMRDHLSKSKVTETELAKPLFDALLRVALGNHSADFEHDDAMTEKSHQSEEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDSETWDDGVDLKPEAESFIASSSPNDLLENLSQGEIIYPEICTLELNLLSTGKAKLDVLAHVFESFLKIIRQKEKNIFLLMQQGTVKNLLGGFLSILTQTDSDFQACQRVLVDLLVSLMSSRTCSEELTLLLRIFLEKSPCTEILLLGILKIVESDITMSPSQYLTFPLLHTPNLSNGVSSQKCPGILNSKAMGLLRRARVSQSKKEGDSESFPQQLLSSWHIAPVHLPLLGQPHLSEGFSISLWFNVECIHEPESTTEKGKKTRKRNKSLVLLDSSFDGTENNRLEGAAYVNPGERLIEEGCVHMISLGSKALIIQVWADPHTGTFIFRVCMDSNDDTKVVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKKNIHGKISIWISGQRKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEESLQLAGKWDLGNLLLFNGAKIGSQEAFYLYACGPNHTSIMPCKYGKPVNDYSKYINTEILQCEQIRELFMTSKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVHNILLEPHHLKNLQPTECKTLQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRIHELENCNGLSMIHQVLIKQKCIVGFHILKTLLEGCCGEDIIHINENGELKLDVESNAIIQDVKLLEELLLDWKIWNKAEHGVWETLLAALEVLIRADHQQQMFNIKQLLKARVVHHFLLTCQVLQEHKEGQLISMPQEVCRSFVKITAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVQSIMYLRHSSSGGKSVTSPGFMIISPSDFTASPPEGNNSSSAVPKQVTASMLRSRSLPAFPTASPHIKPRKLTGSLGCSIDKLQSFVDDGVASQPEKWSPLRSSETLEKSKQDAFISSCESAKMVCETEPALLAQASVSDIPKGALELPAVNIDHKDFGAEPRSDDDSPGDESCPRRPLYLKGLASFQRSHSTIASLGLAFPSQNGSAAVGRWPSLVDRNADDWENFALSLGYEPHHSRTAGAHSVTEDCLVPICCGLYELLSGVLLILPDVMLEDVMDRLIQADTLLVLVNHPSPAVQQEVIKLLDAYFNRASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMFFGRRIGLDEEFDLEDVKNMGLFQKWSVIPILGLIETSLYDNVLLHNALLLLLQILNSCSKVADMLLDNGLLYVLCNTVATLNGLEKIIPLNEYRLLACDIQQLFIAVTIHACSSSGSQYFRVIEDLIVLLGYLQNSKNKRTQNMAVALQFRVLQAAMEFIRTTANHDSENLTDSLQSPSAPHHTMFQKRKSIAGSVPMKDSITPHLPRRHFGSYGHLPMPFSFNPVNQDSVTSFSPGSTPCGVPLGAGPRKFLLAQTDSLLMKMRSVASDELHVMMQRRMSQENPVQATETELAQRLQRLTVFAVNRIVYQEFNPDIIDILSTPESTTQSRTSASQTEISEENIHHEQPSVFNPFQKEMFMYLVEGFKVSSASGKTSSSKQQWAKILWSCKETFRMQLGRLLVHMLSPAHPSQERKQIFEIVREPNHQEILRECLSPSLQHGAKLVLYLSELIHNHKDELTEEELDTAELLMNALKLCGHKCIPPSASTKSDLIRVIKEEQRKYETEEGVNKANWQKTVNNNQQSLFQRLDSKSKDISKIAADITQAVSLSQGIERKKVIQHIRGMYKVDLSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCYLTIPNKYLLRDRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVECSNLQGELEPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRNDVYHSILTNNLPNLLEYGNITALTHLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLSDPSVYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFQSAHASRPGSKLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQSEPPINFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYSNRFTSGTPSEIEMESQIHLYGHTEEISSLFVCKPYSIMISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETTGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGISINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIVSLTFSCDGHHLYTANSDGTVIAWCRKDQQRLKHPMFYSFLSSYAAG", "length": 3850, "header": "tr|F1MLZ4-1|F1MLZ4_BOVIN Isoform 1 of Lysosomal-trafficking regulator OS=Bos taurus OX=9913 GN=LYST PE=4 SV=3 CANONICAL=F1MLZ4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MD56-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MD56/entry", "sequence": { "sequence": "MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQEEKATDFNLPFSAGIILTKEKNSSSQRSTQEKLYLEGSAPAGQVSAKVNVFRKSRRQRKTTHRYSVRDARKTQLSTSDSEVNSDDKSIVMTKYRRSHVLQHFVKQCPKEDHLTAKLNHLSTKEQTPPDTMALENSREIIPREESNTDILSEPAALSTISHMNNSPFDLCHVLLSLLEKVCKFDITLNHNSALAASVVPTLTEFLAGFGDCCNLSDNLEGQMVSAGWTEEPVALIQRMLFRTVLHLMSVDISMAEVMPENLRKNLTELLRAALKIRTFLEKQPDPFAPRQKKTLQEVQDDFVFSKYCHRVLLLPELLEGVLQILICCLQSAASNPFFFSQAMDLVQEFIQHHGFHLFETAVLQMEWLVVRDGVPPEASGHLKALINNVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGDVYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVQNIGICCCMDPKSVIVPLLHAFKLPALKSCQQHILNILNKLILDQLGGAEIPQKTKKAACNICTVDSDQLAKLEETLQGSSYNAEPSSGLSSPSYRFQGILPSSGSEDLLWKWDALEAYQNFVFEEDRLQSVQIANHICSLIQKGNVVVQWKLYNCIFNPVLQRGVELAHHCQQLSISSAQTHVCSHHNQCLPQEVLQIYLKTLPTLLKSRVIRDLFLSCNGVNQIIELNYLDGIRNHSLKAFETLIISLGEQQKDSSIPGIDGIDLEQKELSSLNVGTLYNQQAYSDSQSLSKFYARLKDAYPKKRKSVVQDIHISTINLFLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLQHMLPCFSLESLVLPSPRHMHQAADVWSMCRWIYMLSPIFRKQFYRLGGFQVCHKLIFMVIQDLFRNPEEEQGRKEGDRTMNENQDLNRISQPEITVKEDLLSLTVKIDPTPTELSSLKKSADSLGKLESEHLSSINVEQIPAVEAVPEETKVFMSRESETLLQGIRLLEALLAICLHGTRASQQKLELELPNQNLSVETILLEMRDHLSKSKVTETELAKPLFDALLRVALGNHSADFEHDDAMTEKSHQSEEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDSETWDDGVDLKPEAESFIASSSPNDLLENLSQGEIIYPEICTLELNLLSTGKAKLDVLAHVFESFLKIIRQKEKNIFLLMQQGTVKNLLGGFLSILTQTDSDFQACQRVLVDLLVSLMSSRTCSEELTLLLRIFLEKSPCTEILLLGILKIVESDITMSPSQYLTFPLLHTPNLSNGVSSQKCPGILNSKAMGLLRRARVSQSKKEGDSESFPQQLLSSWHIAPVHLPLLGQPHLSEGFSISLWFNVECIHEPESTTEKGKKTRKRNKSLVLLDSSFDGTENNRLEGAAYVNPGERLIEEGCVHMISLGSKALIIQVWADPHTGTFIFRVCMDSNDDTKVVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKKNIHGKISIWISGQRKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEESLQLAGKWDLGNLLLFNGAKIGSQEAFYLYACGPNHTSIMPCKYGKPVNDYSKYINTEILQCEQIRELFMTSKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVHNILLEPHHLKNLQPTECKTLQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRIHELENCNGLSMIHQVLIKQKCIVGFHILKTLLEGCCGEDIIHINENGELKLDVESNAIIQDVKLLEELLLDWKIWNKAEHGVWETLLAALEVLIRADHQQQMFNIKQLLKARVVHHFLLTCQVLQEHKEGQLISMPQEVCRSFVKITAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVQSIMYLRHSSSGGKSVTSPGFMIISPSDFTASPPEGNNSSSAVPKQVTASMLRSRSLPAFPTASPHIKPRKLTGSLGCSIDKLQSFVDDGVASQPEKWSPLRSSETLEKSKQDAFISSCESAKMVCETEPALLAQASVSDIPKGALELPAVNIDHKDFGAEPRSDDDSPGDESCPRRPLYLKGLASFQRSHSTIASLGLAFPSQNGSAAVGRWPSLVDRNADDWENFALSLGYEPHHSRTAGAHSVTEDCLVPICCGLYELLSGVLLILPDVMLEDVMDRLIQADTLLVLVNHPSPAVQQEVIKVRANTKYVALIWKNKYMCTLKFECIFDLEDVKNMGLFQKWSVIPILGLIETSLYDNVLLHNALLLLLQILNSCSKVADMLLDNGLLYVLCNTVATLNGLEKIIPLNEYRLLACDIQQLFIAVTIHACSSSGSQYFRVIEDLIVLLGYLQNSKNKRTQNMAVALQFRVLQAAMEFIRTTANHDSENLTDSLQSPSAPHHTMFQKRKSIAGPRKFLLAQTDSLLMKMRSVASDELHVMMQRRMSQENPVQATETELAQRLQRLTVFAVNRIVYQEFNPDIIDILSTPESTTQSRTSASQTEISEENIHHEQPSVFNPFQKEMFMYLVEGFKVSSASGKTSSSKQQWAKILWSCKETFRMQLGRLLVHMLSPAHPSQERKQIFEIVREPNHQEILRECLSPSLQHGAKLVLYLSELIHNHKDELTEEELDTAELLMNALKLCGHKCIPPSASTKSDLIRVIKEEQRKYETEEGVNKANWQKTVNNNQQSLFQRLDSKSKDISKIAADITQAVSLSQGIERKKVIQHIRGMYKVDLSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCYLTIPNKYLLRDRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVECSNLQGELEPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRNDVYHSILTNNLPNLLEYGNITALTHLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLSDPSVYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFQSAHASRPGSKLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQSEPPINFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYSNRFTSGTPSEIEMESQIHLYGHTEEISSLFVCKPYSIMISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETTGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGISINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIVSLTFSCDGHHLYTANSDGTVIAWCRKDQQRLKHPMFYSFLSSYAAG", "length": 3764, "header": "tr|A0A3Q1MD56-1|F1MLZ4_BOVIN Computationally mapped isoform of Lysosomal-trafficking regulator OS=Bos taurus OX=9913 GN=LYST PE=4 SV=1 CANONICAL=F1MLZ4-1" }, "locus": { "chromosome": "28", "start_pos": 8523114, "end_pos": 8379906, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081647.2", "url": "https://www.ensembl.org/id/ENSBTAT00000081647.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066761.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066761.1" } ] } }, { "isoform_ac": "A0AAA9SLS8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLS8/entry", "sequence": { "sequence": "MLKQFSPAVPVTEQKANRLNLDGDWKGSSVMSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQEEKATDFNLPFSAGIILTKEKNSSSQRSTQEKLYLEGSAPAGQVSAKVNVFRKSRRQRKTTHRYSVRDARKTQLSTSDSEVNSDDKSIVMTKYRRSHVLQHFVKQCPKEDHLTAKLNHLSTKEQTPPDTMALENSREIIPREESNTDILSEPAALSTISHMNNSPFDLCHVLLSLLEKVCKFDITLNHNSALAASVVPTLTEFLAGFGDCCNLSDNLEGQMVSAGWTEEPVALIQRMLFRTVLHLMSVDISMAEVMPENLRKNLTELLRAALKIRTFLEKQPDPFAPRQKKTLQEVQDDFVFSKYCHRVLLLPELLEGVLQILICCLQSAASNPFFFSQAMDLVQEFIQHHGFHLFETAVLQMEWLVVRDGVPPEASGHLKALINNVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGDVYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVQNIGICCCMDPKSVIVPLLHAFKLPALKSCQQHILNILNKLILDQLGGAEIPQKTKKAACNICTVDSDQLAKLEETLQGSSYNAEPSSGLSSPSYRFQGILPSSGSEDLLWKWDALEAYQNFVFEEDRLQSVQIANHICSLIQKGNVVVQWKLYNCIFNPVLQRGVELAHHCQQLSISSAQTHVCSHHNQCLPQEVLQIYLKTLPTLLKSRVIRDLFLSCNGVNQIIELNYLDGIRNHSLKAFETLIISLGEQQKDSSIPGIDGIDLEQKELSSLNVGTLYNQQAYSDSQSLSKFYARLKDAYPKKRKSVVQDIHISTINLFLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLQHMLPCFSLESLVLPSPRHMHQAADVWSMCRWIYMLSPIFRKQFYRLGGFQVCHKLIFMVIQDLFRNPEEEQGRKEGDRTMNENQDLNRISQPEITVKEDLLSLTVKIDPTPTELSSLKKSADSLGKLESEHLSSINVEQIPAVEAVPEETKVFMSRESETLLQGIRLLEALLAICLHGTRASQQKLELELPNQNLSVETILLEMRDHLSKSKVTETELAKPLFDALLRVALGNHSADFEHDDAMTEKSHQSEEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDSETWDDGVDLKPEAESFIASSSPNDLLENLSQGEIIYPEICTLELNLLSTGKAKLDVLAHVFESFLKIIRQKEKNIFLLMQQGTVKNLLGGFLSILTQTDSDFQACQRVLVDLLVSLMSSRTCSEELTLLLRIFLEKSPCTEILLLGILKIVESDITMSPSQYLTFPLLHTPNLSNGVSSQKCPGILNSKAMGLLRRARVSQSKKEGDSESFPQQLLSSWHIAPVHLPLLGQPHLSEGFSISLWFNVECIHEPESTTEKGKKTRKRNKSLVLLDSSFDGTENNRLEGAAYVNPGERLIEEGCVHMISLGSKALIIQVWADPHTGTFIFRVCMDSNDDTKVVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKKNIHGKISIWISGQRKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEESLQLAGKWDLGNLLLFNGAKIGSQEAFYLYACGPNHTSIMPCKYGKPVNDYSKYINTEILQCEQIRELFMTSKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVHNILLEPHHLKNLQPTECKTLQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRIHELENCNGLSMIHQVLIKQKCIVGFHILKTLLEGCCGEDIIHINENGELKLDVESNAIIQDVKLLEELLLDWKIWNKAEHGVWETLLAALEVLIRADHQQQMFNIKQLLKARVVHHFLLTCQVLQEHKEGQLISMPQEVCRSFVKITAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVQSIMYLRHSSSGGKSVTSPGFMIISPSDFTASPPEGNNSSSAVPKQVTASMLRSRSLPAFPTASPHIKPRKLTGSLGCSIDKLQSFVDDGVASQPEKWSPLRSSETLEKSKQDAFISSCESAKMVCETEPALLAQASVSDIPKGALELPAVNIDHKDFGAEPRSDDDSPGDESCPRRPLYLKGLASFQRSHSTIASLGLAFPSQNGSAAVGRWPSLVDRNADDWENFALSLGYEPHHSRTAGAHSVTEDCLVPICCGLYELLSGVLLILPDVMLEDVMDRLIQADTLLVLVNHPSPAVQQEVIKLLDAYFNRASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMFFGRRIGLDEEFDLEDVKNMGLFQKWSVIPILGLIETSLYDNVLLHNALLLLLQILNSCSKVADMLLDNGLLYVLCNTVATLNGLEKIIPLNEYRLLACDIQQLFIAVTIHACSSSGSQYFRVIEDLIVLLGYLQNSKNKRTQNMAVALQFRVLQAAMEFIRTTANHDSENLTDSLQSPSAPHHTMFQKRKSIAGPRKFLLAQTDSLLMKMRSVASDELHVMMQRRMSQENPVQATETELAQRLQRLTVFAVNRIVYQEFNPDIIDILSTPESTTQSRTSASQTEISEENIHHEQPSVFNPFQKEMFMYLVEGFKVSSASGKTSSSKQQWAKILWSCKETFRMQLGRLLVHMLSPAHPSQERKQIFEIVREPNHQEILRECLSPSLQHGAKLVLYLSELIHNHKDELTEEELDTAELLMNALKLCGHKCIPPSASTKSDLIRVIKEEQRKYETEEGVNKANWQKTVNNNQQSLFQRLDSKSKDISKIAADITQAVSLSQGIERKKVIQHIRGMYKVDLSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCYLTIPNKYLLRDRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVECSNLQGELEPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRNDVYHSILTNNLPNLLEYGNITALTHLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLSDPSVYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFQSAHASRPGSKLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQSEPPINFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYSNRFTSGTPSEIEMESQIHLYGHTEEISSLFVCKPYSIMISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETTGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGISINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIVSLTFSCDGHHLYTANSDGTVIAWCRKDQQRLKHPMFYSFLSSYAAG", "length": 3826, "header": "tr|A0AAA9SLS8-1|F1MLZ4_BOVIN Computationally mapped isoform of Lysosomal-trafficking regulator OS=Bos taurus OX=9913 GN=LYST PE=4 SV=1 CANONICAL=F1MLZ4-1" }, "locus": { "chromosome": "28", "start_pos": 8548360, "end_pos": 8379906, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116129.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116129.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084896.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084896.1" } ] } }, { "isoform_ac": "A0AAA9TYN1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYN1/entry", "sequence": { "sequence": "MCSMDQMRGPSPGLGPHPPERALTCREELLTLLLSLLPLVWKIPVQEEKATDFNLPFSAGIILTKEKNSSSQRSTQEKLYLEGSAPAGQVSAKVNVFRKSRRQRKTTHRYSVRDARKTQLSTSDSEVNSDDKSIVMTKYRRSHVLQHFVKQCPKEDHLTAKLNHLSTKEQTPPDTMALENSREIIPREESNTDILSEPAALSTISHMNNSPFDLCHVLLSLLEKVCKFDITLNHNSALAASVVPTLTEFLAGFGDCCNLSDNLEGQMVSAGWTEEPVALIQRMLFRTVLHLMSVDISMAEVMPENLRKNLTELLRAALKIRTFLEKQPDPFAPRQKKTLQEVQDDFVFSKYCHRVLLLPELLEGVLQILICCLQSAASNPFFFSQAMDLVQEFIQHHGFHLFETAVLQMEWLVVRDGVPPEASGHLKALINNVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGDVYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVQNIGICCCMDPKSVIVPLLHAFKLPALKSCQQHILNILNKLILDQLGGAEIPQKTKKAACNICTVDSDQLAKLEETLQGSSYNAEPSSGLSSPSYRFQGILPSSGSEDLLWKWDALEAYQNFVFEEDRLQSVQIANHICSLIQKGNVVVQWKLYNCIFNPVLQRGVELAHHCQQLSISSAQTHVCSHHNQCLPQEVLQIYLKTLPTLLKSRVIRDLFLSCNGVNQIIELNYLDGIRNHSLKAFETLIISLGEQQKDSSIPGIDGIDLEQKELSSLNVGTLYNQQAYSDSQSLSKFYARLKDAYPKKRKSVVQDIHISTINLFLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLQHMLPCFSLESLVLPSPRHMHQAADVWSMCRWIYMLSPIFRKQFYRLGGFQVCHKLIFMVIQDLFRNPEEEQGRKEGDRTMNENQDLNRISQPEITVKEDLLSLTVKIDPTPTELSSLKKSADSLGKLESEHLSSINVEQIPAVEAVPEETKVFMSRESETLLQGIRLLEALLAICLHGTRASQQKLELELPNQNLSVETILLEMRDHLSKSKVTETELAKPLFDALLRVALGNHSADFEHDDAMTEKSHQSEEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDSETWDDGVDLKPEAESFIASSSPNDLLENLSQGEIIYPEICTLELNLLSTGKAKLDVLAHVFESFLKIIRQKEKNIFLLMQQGTVKNLLGGFLSILTQTDSDFQACQRVLVDLLVSLMSSRTCSEELTLLLRIFLEKSPCTEILLLGILKIVESDITMSPSQYLTFPLLHTPNLSNGVSSQKCPGILNSKAMGLLRRARVSQSKKEGDSESFPQQLLSSWHIAPVHLPLLGQPHLSEGFSISLWFNVECIHEPESTTEKGKKTRKRNKSLVLLDSSFDGTENNRLEGAAYVNPGERLIEEGCVHMISLGSKALIIQVWADPHTGTFIFRVCMDSNDDTKVVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKKNIHGKISIWISGQRKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEESLQLAGKWDLGNLLLFNGAKIGSQEAFYLYACGPNHTSIMPCKYGKPVNDYSKYINTEILQCEQIRELFMTSKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVHNILLEPHHLKNLQPTECKTLQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRIHELENCNGLSMIHQVLIKQKCIVGFHILKTLLEGCCGEDIIHINENGELKLDVESNAIIQDVKLLEELLLDWKIWNKAEHGVWETLLAALEVLIRADHQQQMFNIKQLLKARVVHHFLLTCQVLQEHKEGQLISMPQEVCRSFVKITAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVQSIMYLRHSSSGGKSVTSPGFMIISPSDFTASPPEGNNSSSAVPKQVTASMLRSRSLPAFPTASPHIKPRKLTGSLGCSIDKLQSFVDDGVASQPEKWSPLRSSETLEKSKQDAFISSCESAKMVCETEPALLAQASVSDIPKGALELPAVNIDHKDFGAEPRSDDDSPGDESCPRRPLYLKGLASFQRSHSTIASLGLAFPSQNGSAAVGRWPSLVDRNADDWENFALSLGYEPHHSRTAGAHSVTEDCLVPICCGLYELLSGVLLILPDVMLEDVMDRLIQADTLLVLVNHPSPAVQQEVIKLLDAYFNRASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMFFGRRIGLDEEFDLEDVKNMGLFQKWSVIPILGLIETSLYDNVLLHNALLLLLQILNSCSKVADMLLDNGLLYVLCNTVATLNGLEKIIPLNEYRLLACDIQQLFIAVTIHACSSSGSQYFRVIEDLIVLLGYLQNSKNKRTQNMAVALQFRVLQAAMEFIRTTANHDSENLTDSLQSPSAPHHTMFQKRKSIAGPRKFLLAQTDSLLMKMRSVASDELHVMMQRRMSQENPVQATETELAQRLQRLTVFAVNRIVYQEFNPDIIDILSTPESTTQSRTSASQTEISEENIHHEQPSVFNPFQKEMFMYLVEGFKVSSASGKTSSSKQQWAKILWSCKETFRMQLGRLLVHMLSPAHPSQERKQIFEIVREPNHQEILRECLSPSLQHGAKLVLYLSELIHNHKDELTEEELDTAELLMNALKLCGHKCIPPSASTKSDLIRVIKEEQRKYETEEGVNKANWQKTVNNNQQSLFQRLDSKSKDISKIAADITQAVSLSQGIERKKVIQHIRGMYKVDLSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCYLTIPNKYLLRDRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVECSNLQGELEPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRNDVYHSILTNNLPNLLEYGNITALTHLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLSDPSVYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFQSAHASRPGSKLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQSEPPINFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYSNRFTSGTPSEIEMESQIHLYGHTEEISSLFVCKPYSIMISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETTGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGISINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIVSLTFSCDGHHLYTANSDGTVIAWCRKDQQRLKHPMFYSFLSSYAAG", "length": 3753, "header": "tr|A0AAA9TYN1-1|F1MLZ4_BOVIN Computationally mapped isoform of Lysosomal-trafficking regulator OS=Bos taurus OX=9913 GN=LYST PE=4 SV=1 CANONICAL=F1MLZ4-1" }, "locus": { "chromosome": "28", "start_pos": 8508332, "end_pos": 8379906, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100283.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100283.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102613.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102613.1" } ] } }, { "isoform_ac": "F1MLZ4-1", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4/entry", "sequence": { "sequence": "MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQEEKATDFNLPFSAGIILTKEKNSSSQRSTQEKLYLEGSAPAGQVSAKVNVFRKSRRQRKTTHRYSVRDARKTQLSTSDSEVNSDDKSIVMTKYRRSHVLQHFVKQCPKEDHLTAKLNHLSTKEQTPPDTMALENSREIIPREESNTDILSEPAALSTISHMNNSPFDLCHVLLSLLEKVCKFDITLNHNSALAASVVPTLTEFLAGFGDCCNLSDNLEGQMVSAGWTEEPVALIQRMLFRTVLHLMSVDISMAEVMPENLRKNLTELLRAALKIRTFLEKQPDPFAPRQKKTLQEVQDDFVFSKYCHRVLLLPELLEGVLQILICCLQSAASNPFFFSQAMDLVQEFIQHHGFHLFETAVLQMEWLVVRDGVPPEASGHLKALINNVMKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGDVYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVQNIGICCCMDPKSVIVPLLHAFKLPALKSCQQHILNILNKLILDQLGGAEIPQKTKKAACNICTVDSDQLAKLEETLQGSSYNAEPSSGLSSPSYRFQGILPSSGSEDLLWKWDALEAYQNFVFEEDRLQSVQIANHICSLIQKGNVVVQWKLYNCIFNPVLQRGVELAHHCQQLSISSAQTHVCSHHNQCLPQEVLQIYLKTLPTLLKSRVIRDLFLSCNGVNQIIELNYLDGIRNHSLKAFETLIISLGEQQKDSSIPGIDGIDLEQKELSSLNVGTLYNQQAYSDSQSLSKFYARLKDAYPKKRKSVVQDIHISTINLFLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLQHMLPCFSLESLVLPSPRHMHQAADVWSMCRWIYMLSPIFRKQFYRLGGFQVCHKLIFMVIQDLFRNPEEEQGRKEGDRTMNENQDLNRISQPEITVKEDLLSLTVKIDPTPTELSSLKKSADSLGKLESEHLSSINVEQIPAVEAVPEETKVFMSRESETLLQGIRLLEALLAICLHGTRASQQKLELELPNQNLSVETILLEMRDHLSKSKVTETELAKPLFDALLRVALGNHSADFEHDDAMTEKSHQSEEELSSQPGDFSEEAEDSQCCSFKLLVEEEGYEADSESNPEDSETWDDGVDLKPEAESFIASSSPNDLLENLSQGEIIYPEICTLELNLLSTGKAKLDVLAHVFESFLKIIRQKEKNIFLLMQQGTVKNLLGGFLSILTQTDSDFQACQRVLVDLLVSLMSSRTCSEELTLLLRIFLEKSPCTEILLLGILKIVESDITMSPSQYLTFPLLHTPNLSNGVSSQKCPGILNSKAMGLLRRARVSQSKKEGDSESFPQQLLSSWHIAPVHLPLLGQPHLSEGFSISLWFNVECIHEPESTTEKGKKTRKRNKSLVLLDSSFDGTENNRLEGAAYVNPGERLIEEGCVHMISLGSKALIIQVWADPHTGTFIFRVCMDSNDDTKVVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKKNIHGKISIWISGQRKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEESLQLAGKWDLGNLLLFNGAKIGSQEAFYLYACGPNHTSIMPCKYGKPVNDYSKYINTEILQCEQIRELFMTSKDVDIGLLIESLSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVHNILLEPHHLKNLQPTECKTLQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRIHELENCNGLSMIHQVLIKQKCIVGFHILKTLLEGCCGEDIIHINENGELKLDVESNAIIQDVKLLEELLLDWKIWNKAEHGVWETLLAALEVLIRADHQQQMFNIKQLLKARVVHHFLLTCQVLQEHKEGQLISMPQEVCRSFVKITAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVQSIMYLRHSSSGGKSVTSPGFMIISPSDFTASPPEGNNSSSAVPKQVTASMLRSRSLPAFPTASPHIKPRKLTGSLGCSIDKLQSFVDDGVASQPEKWSPLRSSETLEKSKQDAFISSCESAKMVCETEPALLAQASVSDIPKGALELPAVNIDHKDFGAEPRSDDDSPGDESCPRRPLYLKGLASFQRSHSTIASLGLAFPSQNGSAAVGRWPSLVDRNADDWENFALSLGYEPHHSRTAGAHSVTEDCLVPICCGLYELLSGVLLILPDVMLEDVMDRLIQADTLLVLVNHPSPAVQQEVIKLLDAYFNRASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMFFGRRIGLDEEFDLEDVKNMGLFQKWSVIPILGLIETSLYDNVLLHNALLLLLQILNSCSKVADMLLDNGLLYVLCNTVATLNGLEKIIPLNEYRLLACDIQQLFIAVTIHACSSSGSQYFRVIEDLIVLLGYLQNSKNKRTQNMAVALQFRVLQAAMEFIRTTANHDSENLTDSLQSPSAPHHTMFQKRKSIAGSVPMKDSITPHLPRRHFGSYGHLPMPFSFNPVNQDSVTSFSPGSTPCGVPLGAGPRKFLLAQTDSLLMKMRSVASDELHVMMQRRMSQENPVQATETELAQRLQRLTVFAVNRIVYQEFNPDIIDILSTPESTTQSRTSASQTEISEENIHHEQPSVFNPFQKEMFMYLVEGFKVSSASGKTSSSKQQWAKILWSCKETFRMQLGRLLVHMLSPAHPSQERKQIFEIVREPNHQEILRECLSPSLQHGAKLVLYLSELIHNHKDELTEEELDTAELLMNALKLCGHKCIPPSASTKSDLIRVIKEEQRKYETEEGVNKANWQKTVNNNQQSLFQRLDSKSKDISKIAADITQAVSLSQGIERKKVIQHIRGMYKVDLSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCYLTIPNKYLLRDRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVECSNLQGELEPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRNDVYHSILTNNLPNLLEYGNITALTHLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLSDPSVYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFQSAHASRPGSKLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQSEPPINFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYSNRFTSGTPSEIEMESQIHLYGHTEEISSLFVCKPYSIMISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETTGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGISINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIVSLTFSCDGHHLYTANSDGTVIAWCRKDQQRLKHPMFYSFLSSYAAG", "length": 3850, "header": "tr|F1MLZ4-1|F1MLZ4_BOVIN Isoform 1 of Lysosomal-trafficking regulator OS=Bos taurus OX=9913 GN=LYST PE=4 SV=3 CANONICAL=F1MLZ4-1" }, "locus": { "chromosome": "28", "start_pos": 8523114, "end_pos": 8379906, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022355.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022355.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022355.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022355.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1046, "start_aa": "Thr", "end_pos": 1046, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1046", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "defense response to other organism", "id": "GO:0098542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098542", "evidence": [ { "database": "UniProtKB", "id": "F1MLZ4", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" } ], "pmid": "" }, { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "F1MLZ4", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1MLZ4", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" } ], "pmid": "" }, { "name": "pigmentation", "id": "GO:0043473", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043473", "evidence": [ { "database": "UniProtKB", "id": "F1MLZ4", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" } ], "pmid": "" }, { "name": "lymphocyte mediated immunity", "id": "GO:0002449", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002449", "evidence": [ { "database": "UniProtKB", "id": "F1MLZ4", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" } ], "pmid": "" }, { "name": "lysosome organization", "id": "GO:0007040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007040", "evidence": [ { "database": "UniProtKB", "id": "F1MLZ4", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" } ], "pmid": "" }, { "name": "endosome to lysosome transport via multivesicular body sorting pathway", "id": "GO:0032510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032510", "evidence": [ { "database": "UniProtKB", "id": "F1MLZ4", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" } ], "pmid": "" }, { "name": "natural killer cell mediated cytotoxicity", "id": "GO:0042267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042267", "evidence": [ { "database": "UniProtKB", "id": "F1MLZ4", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MLZ4", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MLZ4", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "F1MLZ4", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" } ], "pmid": "" }, { "name": "microtubule cytoskeleton", "id": "GO:0015630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "evidence": [ { "database": "UniProtKB", "id": "F1MLZ4", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 111, "end_pos": 113, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1130, "end_pos": 1132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1169, "end_pos": 1171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1258, "end_pos": 1260, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1402, "end_pos": 1404, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1496, "end_pos": 1498, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1637, "end_pos": 1639, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1687, "end_pos": 1689, "annotation": 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814, "end_pos": 816, "annotation": "n_glycosylation_sequon" }, { "start_pos": 919, "end_pos": 921, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MLZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" }, { "id": "PS50197", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50197" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BEACH", "eco_id": "ECO_0000259", "start_pos": 3169, "end_pos": 3471, "start_aa": "Pro", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MLZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLZ4" }, { "id": "PS51783", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51783" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BEACH-type PH", "eco_id": "ECO_0000259", "start_pos": 3058, "end_pos": 3164, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1046 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 111, "end_pos": 113 }, { "start_pos": 1130, "end_pos": 1132 }, { "start_pos": 1169, "end_pos": 1171 }, { "start_pos": 1258, "end_pos": 1260 }, { "start_pos": 1402, "end_pos": 1404 }, { "start_pos": 1496, "end_pos": 1498 }, { "start_pos": 1637, "end_pos": 1639 }, { "start_pos": 1687, "end_pos": 1689 }, { "start_pos": 2081, "end_pos": 2083 }, { "start_pos": 2082, "end_pos": 2084 }, { "start_pos": 2249, "end_pos": 2251 }, { "start_pos": 251, "end_pos": 253 }, { "start_pos": 2565, "end_pos": 2567 }, { "start_pos": 301, "end_pos": 303 }, { "start_pos": 3095, "end_pos": 3097 }, { "start_pos": 3176, "end_pos": 3178 }, { "start_pos": 3237, "end_pos": 3239 }, { "start_pos": 3325, "end_pos": 3327 }, { "start_pos": 352, "end_pos": 354 }, { "start_pos": 3576, "end_pos": 3578 }, { "start_pos": 814, "end_pos": 816 }, { "start_pos": 919, "end_pos": 921 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"uniprot_ac": "F1MM93", "uniprot_id": "F1MM93_BOVIN", "mass": { "chemical_mass": 74599.0, "monoisotopic_mass": 74599.0 }, "refseq": { "ac": "XP_005223380", "name": "FYVE, RhoGEF and PH domain-containing protein 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223380" }, "gene_names": [ { "name": "FGD2", "type": "recommended", "evidence": [ { "id": "F1MM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM93" } ] }, { "name": "FGD2", "type": "synonym", "evidence": [ { "id": "XP_005223380", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223380" } ] } ], "protein_names": [ { "name": "FYVE, RhoGEF and PH domain containing 2", "type": "synonym", "evidence": [ { "id": "F1MM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM93/entry#names_and_taxonomy" } ] }, { "name": "FYVE, RhoGEF and PH domain-containing protein 2 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005223380", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223380" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MM93", "url": "https://www.uniprot.org/uniprotkb/F1MM93" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FGD2", "url": "https://www.uniprot.org/uniprotkb/F1MM93", "locus": { "chromosome": "23", "start_pos": 10942795, "end_pos": 10913924, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014172", "url": "https://www.ensembl.org/id/ENSBTAG00000014172" } ] } } ], "crossref": [ { "id": "F1MM93", "url": "https://alphafold.ebi.ac.uk/entry/F1MM93", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014172", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014172", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13236", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13236", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13386", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13386", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15741", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15741", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "512593", "url": "https://www.ncbi.nlm.nih.gov/gene/512593", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000306", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000306", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035941", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035941", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037797", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037797", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051092", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051092", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WTEKCPP", "url": "https://omabrowser.org/oma/group/WTEKCPP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MJL7", "url": "https://www.orthodb.org/?gene=A0A3Q1MJL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MM93", "url": "https://www.orthodb.org/?gene=F1MM93", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12673", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12673", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12673:SF82", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12673:SF82", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00621", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01363", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01363", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF22697", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22697", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-416482", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005223380", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223380", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJL7", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MJL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUI5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM93", "url": "https://www.uniprot.org/uniprotkb/F1MM93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM93-1", "url": "https://www.uniprot.org/uniprotkb/F1MM93-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGASEETLTSVSSLVTVFENSRMTGAVPRVHGLEAGHQQPGCRAPTSAGPWEKPTVEEALESGSRTVSRRYLSSLKNKLSSGAWRKSYQPRTCPGSGTQEPEEKKIVRELLETEQAYVARLHLLDQVFFQELLKEARSSKAFPEDVVRLIFSNISSIYQFHSQFFLPELQRRLDDWTTTPRIGDVIQKLAPFLKMYSEYVKNFERAIELLATWTDKSPPFQEVITRIQSSEASASLTLQHHMLEPVQRIPRYELLLKEYVQKLPGQAPDLADAQKALDMIFSAAQHSNAAITEMERLQELWDVYQRLGLEDDIVDPSNTLLREGPVLKISFRRSGPMERYLFLFNNMLLYCVPRVIQVGAHFQVRTRIDVAGMKVRELTDAEFPHSFLVSGKQRTLELRARSQEEMISWLQACQAAIDQIEKRNETFKAAVQSPEGDPQEQELQSVELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDANRPNRVCLDCYTFLTGNVLPEEKEDKRRGILEKGAVAGSEQSLICSFLQLLGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVTAGPQADPRVFQLQQSGQLYTFKAESEELKGRWVKAMERAASGWIPGGPDDKDLSD", "length": 656, "header": "tr|F1MM93-1|F1MM93_BOVIN Isoform 1 of FYVE, RhoGEF and PH domain containing 2 OS=Bos taurus OX=9913 GN=FGD2 PE=4 SV=1 CANONICAL=F1MM93-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MJL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MJL7/entry", "sequence": { "sequence": "MEGASEETLTSVSSLVTVFENSRMTGAVPRVHGLEAGHQQPGCRAPTSAGPWEKPTVEEALESGSRTVSRRYLSSLKNKLSSGAWRKSYQPRTCPGSGTQEPEEKKIVRELLETEQAYVARLHLLDQVFFQELLKEARSSKAFPEDVVRLIFSNISSIYQFHSQFFLPELQRRLDDWTTTPRIGDVIQKLAPFLKMYSEYVKNFERAIELLATWTDKSPPFQEVITRIQSSEASASLTLQHHMLEPVQRIPRYELLLKEYVQKLPGQAPDLADAQKALDMIFSAAQHSNAAITEMERLQELWDVYQRLGLEDDIVDPSNTLLREGPVLKISFRRSGPMERYLFLVRELTDAEFPHSFLVSGKQRTLELRARSQEEMISWLQACQAAIDQIEKRNETFKAAVQSPEGDPQEQELQSVELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDANRPNRVCLDCYTFLTGNVLPEEKEDKRRGILEKGAVAGSEQSLICSFLQLLGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVTAGPQADPRVFQLQQSGQLYTFKAESEELKGRWVKAMERAASGWIPGGPDDKDLSD", "length": 625, "header": "tr|A0A3Q1MJL7-1|F1MM93_BOVIN Computationally mapped isoform of FYVE, RhoGEF and PH domain containing 2 OS=Bos taurus OX=9913 GN=FGD2 PE=4 SV=1 CANONICAL=F1MM93-1" }, "locus": { "chromosome": "23", "start_pos": 10942441, "end_pos": 10916687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000081202.3", "url": "https://www.ensembl.org/id/ENSBTAT00000081202.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000071557.1", "url": "https://www.ensembl.org/id/ENSBTAP00000071557.1" } ] } }, { "isoform_ac": "A0AAA9SUI5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUI5/entry", "sequence": { "sequence": "MDYSLRGSSVHGILQARILGMTGAVPRVHGLEAGHQQPGCRAPTSAGPWEKPTVEEALESGSRTVSRRYLSSLKNKLSSGAWRKSYQPRTCPGSGTQEPEEKKIVRELLETEQAYVARLHLLDQVFFQELLKEARSSKAFPEDVVRLIFSNISSIYQFHSQFFLPELQRRLDDWTTTPRIGDVIQKLAPFLKMYSEYVKNFERAIELLATWTDKSPPFQEVITRIQSSEASASLTLQHHMLEPVQRIPRYELLLKEYVQKLPGQAPDLADAQKALDMIFSAAQHSNAAITEMERLQELWDVYQRLGLEDDIVDPSNTLLREGPVLKISFRRSGPMERYLFLVRELTDAEFPHSFLVSGKQRTLELRARSQEEMISWLQACQAAIDQIEKRNETFKAAVQSPEGDPQEQELQSVELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDANRPNRVCLDCYTFLTGNVLPEEKEDKRRGILEKGAVAGSEQSLICSFLQLLGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVTAGPQADPRVFQLQQSGQLYTFKAESEELKGRWVKAMERAASGWIPGGPDDKDLSD", "length": 622, "header": "tr|A0AAA9SUI5-1|F1MM93_BOVIN Computationally mapped isoform of FYVE, RhoGEF and PH domain containing 2 OS=Bos taurus OX=9913 GN=FGD2 PE=4 SV=1 CANONICAL=F1MM93-1" }, "locus": { "chromosome": "23", "start_pos": 10942441, "end_pos": 10914013, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113784.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113784.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089005.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089005.1" } ] } }, { "isoform_ac": "F1MM93-1", "url": "https://www.uniprot.org/uniprotkb/F1MM93/entry", "sequence": { "sequence": "MEGASEETLTSVSSLVTVFENSRMTGAVPRVHGLEAGHQQPGCRAPTSAGPWEKPTVEEALESGSRTVSRRYLSSLKNKLSSGAWRKSYQPRTCPGSGTQEPEEKKIVRELLETEQAYVARLHLLDQVFFQELLKEARSSKAFPEDVVRLIFSNISSIYQFHSQFFLPELQRRLDDWTTTPRIGDVIQKLAPFLKMYSEYVKNFERAIELLATWTDKSPPFQEVITRIQSSEASASLTLQHHMLEPVQRIPRYELLLKEYVQKLPGQAPDLADAQKALDMIFSAAQHSNAAITEMERLQELWDVYQRLGLEDDIVDPSNTLLREGPVLKISFRRSGPMERYLFLFNNMLLYCVPRVIQVGAHFQVRTRIDVAGMKVRELTDAEFPHSFLVSGKQRTLELRARSQEEMISWLQACQAAIDQIEKRNETFKAAVQSPEGDPQEQELQSVELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDANRPNRVCLDCYTFLTGNVLPEEKEDKRRGILEKGAVAGSEQSLICSFLQLLGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVTAGPQADPRVFQLQQSGQLYTFKAESEELKGRWVKAMERAASGWIPGGPDDKDLSD", "length": 656, "header": "tr|F1MM93-1|F1MM93_BOVIN Isoform 1 of FYVE, RhoGEF and PH domain containing 2 OS=Bos taurus OX=9913 GN=FGD2 PE=4 SV=1 CANONICAL=F1MM93-1" }, "locus": { "chromosome": "23", "start_pos": 10942441, "end_pos": 10916687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018834.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018834.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018834.4", "url": "https://www.ensembl.org/id/ENSBTAP00000018834.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-416482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416482", "resource": "Reactome", "description": "G alpha (12/13) signalling events" }, { "id": "R-BTA-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZQB5-1", "protein_name": "FYVE, RhoGEF and PH domain containing 2", "gene_name": "FGD2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEGASKEKLASVSSLVTVFENSRTSGAAPRVHRQEAQHHRPGCRPPSPAESWERPTVGEALESEPRTVSRRYLNSLKNKLSSGAWRKSCQPGTCPSPGTQEPEEKRIVQELLETEQAYVARLHLLDQVFFQELLKEARSSKAFPEDVVRLIFSNISSIYQFHAQFFLPELQRRLDDWTTTPRIGDVIQKLAPFLKMYSEYVKNFERAIELLATWTDKSPPFQEVITRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYVQKLPAQAPDLADAQKALNMIFSAAQHSNAAITEMERLQELWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNGPMERYLFLFNNMLLYCVPRVIQVGAHFQVRTRIDVAGMKVRELTDAEFPHSFLVSGKQRTLELQARSQEEMISWMQACQAAIDQIEKRNETFKAAAQGPEGDAQEQELQSKELGLRAPQWIRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCGRCSDYRAELKYDDNRPNRVCFDCYTFLTGNVIPEDKEDKRRGILEKGSVMGSEQSLMCSFLQLLGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHASIPLLGYQVTAGPQGDPRVFQLQQSGQFYIFKAETEELKGRWVKAMERAASGWSPGEPSDGDLSD", "length": 656 }, "evidence": [ { "id": "F1MM93", "url": "https://omabrowser.org/oma/group/F1MM93/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7F721-1", "protein_name": "FYVE, RhoGEF and PH domain-containing protein 2 isoform X1", "gene_name": "Fgd2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEDTSEEKQQASVCNLVAVFENSRTLGTTPGPHSADEQPQSPERKLPLSPGPWEAPPVEEAMKPEFRPVSRTYLSSLKNKLSSGAWRKSYQPGASPGPETQEPEEKRVVWELLETEQAYVARLHLLDQVFFQELLKEAGRSKAFPEEVVRLIFSNISSIYCFHAQFFLPELQRRVDDWTATPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWMDKSQPFQEIVTRIQRSEASGSLTLQHHMLEPVQRIPRYELLLKEYVQKLPAQAPDRADAQRALDMIFSAAQHSNAAIAEMERLQGLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRSDPMERYLFLFNNMLLYCVPRVLQVGAQFQVRTRIDVAGMKVRELTDAEFPHSFLVSGKQRTLELQARSREEMISWVQACQAAIDQVEKRSETFKAAVQGPQGDAQESKPQAEELGIRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCGKCSDYRAELKYDSNRPNRVCLACYTFLTGNVLPDSKEDKRKGILEKESLAGPDQSLMCSFLQLLGDKWSRSGPRGWCVIPRDDPLVLYVYAAPQDIKAHTSIPLLGYQVIAGPQGDPRVFQLHQSGQMYTFKAESEELQGRWVRAIKRAANGWTPEEPDEEDMSD", "length": 657 }, "evidence": [ { "id": "F1MM93", "url": "https://omabrowser.org/oma/group/F1MM93/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3Z9I3-1", "protein_name": "FYVE, RhoGEF and PH domain-containing protein 4", "gene_name": "Fgd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEQACAKQDSVCNLVAVFENSRSPGAAPGPHSFEDQPHSPEHQLPLSPEPWEAPPAGEALTSEFRPVSRTYLNSLKNKLSSGAWRKSCQPGASPGPETQEPEEKRVVQELLETEQAYVARLHLLDQVFFQELLREASRSKAFPEDVVKLIFSNISSIYRFHAQFFLPELQRRVDDWTATPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWMDKSQPFQEVVTRIQRSEASGSLTLQHHMLEPVQRIPRYELLLKEYVQKLPAQAPDLEDAQRALDMIFSAAQHSNAAIAEMERLQGLWDVYQRLGLEDDIVDPSNTLLREGPVLKISFRRSDPMERYLVLFNNMLLYCVPRVLQVGAQFQVRTRIDVAGMKVRELTDAEFPHSFLVSGKQRTLELQARSREEMVSWIQACQAAIDQVEKRSETFKAAVQGPQGDTQEPKPQAEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCAKCSDYRAELKYDGNRPNRVCLTCYTFLTGNLLPDSKEDKRRGILEKETSAGPDQSVVCSFLQLMGDKSIRSIPRSWCVIPRDDPLVLYVYAAPQDMKAHTSIPLLGYQVTSGPQGDPRVFQLQQSGQQYTFKAESVELQGRWVRAIKRAASGWTPEGPDEEDMSD", "length": 655 }, "evidence": [ { "id": "F1MM93", "url": "https://omabrowser.org/oma/group/F1MM93/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q54SR5-1", "protein_name": "Uncharacterized protein", "gene_name": "gxcV", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNIFRQINKEAIAGTAVNTLTYTNLSNNLNTGQFNNSSQNETITIEQIPNTPLPTSNHPSLDHLVEFTTMRDLKCKEILTTERTYVDNMKILVEVFIKPLKEGEGGISKEIASQICGNIPDILLISIELLNMLESKLANWSNSQTIGDTFNKLTPFLKMYTNYTVGFDSVLTLVTDLEKNSTFSSFIQKCTEDPRTRKLDLRSYLIQPVQRITRYHMLLEEVLKHTDQSHTDYPPLTESYRLMKQVTSDANEAIKKSENRQKVYEIQKMFVTDPGIIAPHREFIYEGTLTKVCRKACKKRVVFLFSDILVYGSSIPPKLLLHEKIELDHCRIEDIPDGNLGGSSSISLNGNLINNAFQICSNKKSFVVFADSSDAKMQWMIVLIETIDKFKAKRKTIKKEKIDHAEAPVWVPDETADNCSRCKDEFSFVNRRHHCRNCGALVCGKCSDQKYKLPSADYKAVRVCNKCHETLTKSALSNLKV", "length": 481 }, "evidence": [ { "id": "F1MM93", "url": "https://omabrowser.org/oma/group/F1MM93/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q7Z6J4-1", "protein_name": "FYVE, RhoGEF and PH domain-containing protein 2", "gene_name": "FGD2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKGASEEKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSATPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVTVGPQGDPRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASGWSPSWPNDGDLSD", "length": 655 }, "evidence": [ { "id": "F1MM93", "url": "https://omabrowser.org/oma/group/F1MM93/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BY35-1", "protein_name": "FYVE, RhoGEF and PH domain-containing protein 2", "gene_name": "Fgd2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MERACEKQDSVCNLVAVFENNRTPGEAPGSHSLEDQPHSPEHQLSLSPEPWEAPPVKEALKSEFRPVSRTYLSSLKNKLSSGAWRRSCQPGVSPGPETQEPEEKRVVRELLETEQAYVARLHLLDQVFFQELLREAGRSKAFPEDVVKLIFSNISSIYRFHAQFFLPELQRRVDDWAATPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWMDKSQPFQEVVTRIQCSEASSSLTLQHHMLEPVQRIPRYELLLKEYVQKLPAQAPDLEDAQRALDMIFSAAQHSNAAIAEMERLQGLWDVYQRLGLEDDIVDPSNTLLREGPVLKISFRRSDPMERYLVLFNNMLLYCVPRVLQVGAQFQVRTRIDVAGMKVRELTDAEFPHSFLVSGKQRTLELQARSRDEMVSWMQACQAAIDQVEKRSETFKAAVQGPQGDTQEPKPQVEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCAKCSDYRAELKYDSNRPNRVCLTCYTFLTGNVLPQGKEDKRRGILEKEASAAPEQSLVCSFLQLIGDKCSRSLPRSWCVIPRDDPLVLYVYAAPQDTKAHTSIPLLGYQVISGPQGDPRVFQLQQSGQQYTFKAESVELQGRWVTAIKRAASGRTPEGPDEEDVSD", "length": 655 }, "evidence": [ { "id": "F1MM93", "url": "https://omabrowser.org/oma/group/F1MM93/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "F1MM93", "url": "https://www.uniprot.org/uniprotkb/F1MM93" } ], "pmid": "" }, { "name": "cell projection", "id": "GO:0042995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "evidence": [ { "database": "UniProtKB", "id": "F1MM93", "url": "https://www.uniprot.org/uniprotkb/F1MM93" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MM93", "url": "https://www.uniprot.org/uniprotkb/F1MM93" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MM93", "url": "https://www.uniprot.org/uniprotkb/F1MM93" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F1MM93", "url": "https://www.uniprot.org/uniprotkb/F1MM93" } ], "pmid": "" }, { "name": "ruffle", "id": "GO:0001726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001726", "evidence": [ { "database": "UniProtKB", "id": "F1MM93", "url": "https://www.uniprot.org/uniprotkb/F1MM93" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MM93", "url": "https://www.uniprot.org/uniprotkb/F1MM93" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "F1MM93", "url": "https://www.uniprot.org/uniprotkb/F1MM93" } ], "pmid": "" }, { "name": "phosphatidylinositol phosphate binding", "id": "GO:1901981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901981", "evidence": [ { "database": "UniProtKB", "id": "F1MM93", "url": "https://www.uniprot.org/uniprotkb/F1MM93" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "filopodium assembly", "id": "GO:0046847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046847", "evidence": [ { "database": "UniProtKB", "id": "F1MM93", "url": "https://www.uniprot.org/uniprotkb/F1MM93" } ], "pmid": "" }, { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "F1MM93", "url": "https://www.uniprot.org/uniprotkb/F1MM93" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 425, "end_pos": 427, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MM93-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 656, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MM93-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MM93" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM93" }, { "id": "PS50010", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50010" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DH", "eco_id": "ECO_0000259", "start_pos": 103, "end_pos": 291, "start_aa": "Glu", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM93" }, { "id": "PS50178", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50178" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FYVE-type", "eco_id": "ECO_0000259", "start_pos": 459, "end_pos": 519, "start_aa": "Asp", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM93" }, { "id": "PS50003", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50003" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PH", "eco_id": "ECO_0000259", "start_pos": 320, "end_pos": 419, "start_aa": "Thr", "end_aa": "Asp", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 154, "end_pos": 156 }, { "start_pos": 425, "end_pos": 427 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMM4-1", "uniprot_ac": "F1MMM4", "uniprot_id": "F1MMM4_BOVIN", "mass": { "chemical_mass": 84061.0, "monoisotopic_mass": 84061.0 }, "refseq": {}, "gene_names": [ { "name": "SYTL5", "type": "recommended", "evidence": [ { "id": "F1MMM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMM4" } ] } ], "protein_names": [ { "name": "Synaptotagmin-like protein 5", "type": "recommended", "evidence": [ { "id": "F1MMM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMM4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1ML47", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML47#function" }, { "database": "UniProtKB", "id": "ARBA00053749", "url": "https://www.uniprot.org/uniprotkb/ARBA00053749#function" }, { "database": "UniProtKB", "id": "F1MMM4", "url": "https://www.uniprot.org/uniprotkb/F1MMM4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMM4", "url": "https://www.uniprot.org/uniprotkb/F1MMM4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYTL5", "url": "https://www.uniprot.org/uniprotkb/F1MMM4", "locus": { "chromosome": "X", "start_pos": 105235088, "end_pos": 105341927, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004955", "url": "https://www.ensembl.org/id/ENSBTAG00000004955" } ] } } ], "crossref": [ { "id": "F1MMM4", "url": "https://alphafold.ebi.ac.uk/entry/F1MMM4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004955", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004955", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04020", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04020", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04029", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04029", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15766", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15766", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010911", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010911", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037303", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037303", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041282", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041282", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043567", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043567", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR45716", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45716", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45716:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45716:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02318", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02318", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0A3Q1ML47", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1ML47-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMM4", "url": "https://www.uniprot.org/uniprotkb/F1MMM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMM4-1", "url": "https://www.uniprot.org/uniprotkb/F1MMM4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQETTRVCAHCQRNLGLIFDRGDPCQACSLRVCSQCRVSGLDGSWRCTICARVAQLRIVTGEWFFEEKAKRFKHVNVLGTDVVRQSILRRSPGDGEIQSQEQTHQNTEKSDALPSSGQKASHDGPRRKGFLLSKFRSATKGEIITPKTESGRSYSLDLDSHNFWSLKSALGSDRGSTGSSDFNEPEAGPGTPKSVRSNGMTPGTPRSPAPSTRSVTSVSSRERGFENSTDLAAIESTSEDLTKTHRRKPSSTPSIAVSRASLSSDRSRSELDLSGSFTEDLEDTISIRSKSVPGALDKDLDSLEEMEDGIDDLVSSRFSSNTHSLASGLSTNSQAGSDRKWTYLSVPDADSDTTSLNSMMSVYSETGDYGNVKVSGEILLHISYSYETGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYTISHAQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPSDEWFVLQPKVECAADISLQYKGELTVMLRYIPPEEKLMPPLGQFQGKKTFKRGKKKDPSIISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSLNPQWNHTFVFSGLHPQDIKHVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMADNPGTPVEGVLMLRASMGKTKL", "length": 754, "header": "tr|F1MMM4-1|F1MMM4_BOVIN Isoform 1 of Synaptotagmin-like protein 5 OS=Bos taurus OX=9913 GN=SYTL5 PE=4 SV=4 CANONICAL=F1MMM4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1ML47-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1ML47/entry", "sequence": { "sequence": "MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQETTRVCAHCQRNLGLIFDRGDPCQACSLRVCSQCRVSGLDGSWRCTICARVAQLRIVTGEWFFEEKAKRFKHVNVLGTDVVRQSILRRSPGDGEIQSQEQTHQNTEKSDALPSSGQKASHDGPRRKGFLLSKFRSATKGEIITPKTESGRSYSLDLDSHNFWSLKSALGSDRGSTGSSDFNEPEAGPGTPKSVRSNGMTPGTPRSPAPSTRSVTSVSSRERGFENSTDLAAIESTSEDLTKTHRRKPSSTPSIAVSRASLSSDRSRSELDLSGSFTEDLEDTISIRSKSVPGALDKDLDSLEEMEDGIDDLVSSRFSSNTHSLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYSYETGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYTISHAQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPSDEWFVLQPKVECAADISLQYKGELTVMLRYIPPEEKLMPPLGQFQGKKTFKRGKKKDPSIISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSLNPQWNHTFVFSGLHPQDIKHVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMADNPGTPVEGVLMLRASMGKTKL", "length": 732, "header": "tr|A0A3Q1ML47-1|F1MMM4_BOVIN Computationally mapped isoform of Synaptotagmin-like protein 5 OS=Bos taurus OX=9913 GN=SYTL5 PE=4 SV=2 CANONICAL=F1MMM4-1" }, "locus": { "chromosome": "X", "start_pos": 105341728, "end_pos": 105235093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070420.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070420.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072358.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072358.2" } ] } }, { "isoform_ac": "F1MMM4-1", "url": "https://www.uniprot.org/uniprotkb/F1MMM4/entry", "sequence": { "sequence": "MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQETTRVCAHCQRNLGLIFDRGDPCQACSLRVCSQCRVSGLDGSWRCTICARVAQLRIVTGEWFFEEKAKRFKHVNVLGTDVVRQSILRRSPGDGEIQSQEQTHQNTEKSDALPSSGQKASHDGPRRKGFLLSKFRSATKGEIITPKTESGRSYSLDLDSHNFWSLKSALGSDRGSTGSSDFNEPEAGPGTPKSVRSNGMTPGTPRSPAPSTRSVTSVSSRERGFENSTDLAAIESTSEDLTKTHRRKPSSTPSIAVSRASLSSDRSRSELDLSGSFTEDLEDTISIRSKSVPGALDKDLDSLEEMEDGIDDLVSSRFSSNTHSLASGLSTNSQAGSDRKWTYLSVPDADSDTTSLNSMMSVYSETGDYGNVKVSGEILLHISYSYETGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYTISHAQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPSDEWFVLQPKVECAADISLQYKGELTVMLRYIPPEEKLMPPLGQFQGKKTFKRGKKKDPSIISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSLNPQWNHTFVFSGLHPQDIKHVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMADNPGTPVEGVLMLRASMGKTKL", "length": 754, "header": "tr|F1MMM4-1|F1MMM4_BOVIN Isoform 1 of Synaptotagmin-like protein 5 OS=Bos taurus OX=9913 GN=SYTL5 PE=4 SV=4 CANONICAL=F1MMM4-1" }, "locus": { "chromosome": "X", "start_pos": 105341728, "end_pos": 105235093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006517.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006517.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006517.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006517.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 308, "start_aa": "Thr", "end_pos": 308, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr308", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "F1MMM4", "url": "https://www.uniprot.org/uniprotkb/F1MMM4" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MMM4", "url": "https://www.uniprot.org/uniprotkb/F1MMM4" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "F1MMM4", "url": "https://www.uniprot.org/uniprotkb/F1MMM4" } ], "pmid": "" }, { "name": "neurexin family protein binding", "id": "GO:0042043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042043", "evidence": [ { "database": "UniProtKB", "id": "F1MMM4", "url": "https://www.uniprot.org/uniprotkb/F1MMM4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "F1MMM4", "url": "https://www.uniprot.org/uniprotkb/F1MMM4" } ], "pmid": "" }, { "name": "exocytosis", "id": "GO:0006887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "evidence": [ { "database": "UniProtKB", "id": "F1MMM4", "url": "https://www.uniprot.org/uniprotkb/F1MMM4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MMM4", "url": "https://www.uniprot.org/uniprotkb/F1MMM4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MMM4", "url": "https://www.uniprot.org/uniprotkb/F1MMM4" } ], "pmid": "" }, { "name": "exocytic vesicle", "id": "GO:0070382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070382", "evidence": [ { "database": "UniProtKB", "id": "F1MMM4", "url": "https://www.uniprot.org/uniprotkb/F1MMM4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 498, "end_pos": 500, "annotation": "n_glycosylation_sequon" }, { "start_pos": 622, "end_pos": 624, "annotation": "n_glycosylation_sequon" }, { "start_pos": 664, "end_pos": 666, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MMM4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 754, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MMM4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MMM4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MMM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMM4" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 430, "end_pos": 551, "start_aa": "Val", "end_aa": "Phe", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MMM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMM4" }, { "id": "PS50916", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50916" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "RabBD", "eco_id": "ECO_0000259", "start_pos": 7, "end_pos": 123, "start_aa": "Phe", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 308 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 283, "end_pos": 285 }, { "start_pos": 498, "end_pos": 500 }, { "start_pos": 622, "end_pos": 624 }, { "start_pos": 664, "end_pos": 666 }, { "start_pos": 9, "end_pos": 11 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMK1-1", "uniprot_ac": "F1MMK1", "uniprot_id": "F1MMK1_BOVIN", "mass": { "chemical_mass": 128847.0, "monoisotopic_mass": 128847.0 }, "refseq": { "ac": "XP_005217424", "name": "laminin subunit beta-3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217424" }, "gene_names": [ { "name": "LAMB3", "type": "recommended", "evidence": [ { "id": "F1MMK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ] }, { "name": "LAMB3", "type": "synonym", "evidence": [ { "id": "XP_005217424", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217424" } ] } ], "protein_names": [ { "name": "Laminin subunit beta 3", "type": "synonym", "evidence": [ { "id": "F1MMK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK1/entry#names_and_taxonomy" } ] }, { "name": "laminin subunit beta-3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005217424", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217424" } ] } ], "function": [ { "annotation": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.", "evidence": [ { "database": "UniProtKB", "id": "A0A3Q1MS19", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS19#function" }, { "database": "UniProtKB", "id": "ARBA00002418", "url": "https://www.uniprot.org/uniprotkb/ARBA00002418#function" }, { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LAMB3", "url": "https://www.uniprot.org/uniprotkb/F1MMK1", "locus": { "chromosome": "16", "start_pos": 73712353, "end_pos": 73669011, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016542", "url": "https://www.ensembl.org/id/ENSBTAG00000016542" } ] } } ], "crossref": [ { "id": "F1MMK1", "url": "https://alphafold.ebi.ac.uk/entry/F1MMK1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016542", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016542", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00055", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00055", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "529939", "url": "https://www.ncbi.nlm.nih.gov/gene/529939", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008211", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008211", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050440", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050440", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056558", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056558", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NKREQFE", "url": "https://omabrowser.org/oma/group/NKREQFE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MS19", "url": "https://www.orthodb.org/?gene=A0A3Q1MS19", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MMK1", "url": "https://www.orthodb.org/?gene=F1MMK1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10574", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10574", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10574:SF268", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10574:SF268", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00053", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00053", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00055", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00055", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23219", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23219", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF24973", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24973", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005217424", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217424", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MS19", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MS19-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMK1-1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPLLLLYFGLPSLLCAQQACSRGACYPPVGDLLIGRTRFLRASSTCGLTKPETYCAQYGEWQMKCCKCDSRVAHNYNSHQVENVVSSSGPTRWWQSQNDVSPVFLQLDLDRKFQLQDIMMDFKGPVPAGLLIERSSDFGKTWQVYQYLAADCGSAFPWVRQGQPQGWQDARCQTLPQRPNGHPNGAKVQLNLMDLASGIPATQSQKIQELGEITNLRVNFTKLAPVPQRGYHPPSAYYAVSQLRLHGSCLCHGHADRCAPSSRTPASPSSAVQVHEVCVCQHNTAGPNCERCAPFYNNRPWRPAEDQDPHECQRCDCNGHSETCHFDPAVFAASQGAHGGVCDNCRDHTEGRNCERCQLHYFRNRRPGAPIQETCIPCECDPDGAVPGAPCDPLTGQCVCKEHVQGERCDLCKPGFTGLTFSNPQGCHRCDCSVLGARRDVPCDEETGRCVCLPHVVGPKCDQCAPHHWKLASGRGCEPCACDPHNSLGPQCNQFTGQCACREGFGGLTCRAAAIRQCPDRTYGDAAAGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCDRAPVCVACHPCFQTYDGGLRERALRLAGLRNASAALWPQPGLEDHGLASRMLDAKSKMEQIQATLGDALVTEEEVAQVANAIFSIRRTLQGLQLDLPLEEETLSLPGDLGSLDRSFNRLLVTYQSKREQFEKISSADPSGAFRMLTAAHQRSSQAAQQVSDSSRRLLQLRDSRREAERLEQQVAGGPGAGGPQLAALRLEMASVPDLTPTINQLCGGSREMPCTPGACPGELCPRDNRTACGSRCRGALPRAGGALRTAGQVAEQLRAFSTQLQQTRQMIRAAEEAASQVQSDTQLLETQVSASRSQMEEDVRRTRLLIQQVREFLSDPDTDTATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDVARARRLQAEAEQARSRAHAVEGQVEEVLGALRQGTLALQEAQDTMRGTRRSMRLIQDRVAEVQQVLGPAERLVTSMTQQLGGFRARMEELGRRARQQQAQAAQARQLAEEASKEALNAQEGFERVKQKYAELKDRLDQSSMLGEQGSRILSVKTEAEELFGETMEMMDRMRDMESELLQGSQAIVLRSADLTGLEQRVEQIRNHINGRVLYYATCK", "length": 1172, "header": "tr|F1MMK1-1|F1MMK1_BOVIN Isoform 1 of Laminin subunit beta 3 OS=Bos taurus OX=9913 GN=LAMB3 PE=4 SV=3 CANONICAL=F1MMK1-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MS19-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MS19/entry", "sequence": { "sequence": "MRPLLLLYFGLPSLLCAQQACSRGACYPPVGDLLIGRTRFLRASSTCGLTKPETYCAQYGEWQMKCCKCDSRVAHNYNSHQVENVVSSSGPTRWWQSQNDVSPVFLQLDLDRKFQLQDIMMDFKGPVPAGLLIERSSDFGKTWQVYQYLAADCGSAFPWVRQGQPQGWQDARCQTLPQRPNGHPNGAKVQLNLMDLASGIPATQSQKIQELGEITNLRVNFTKLAPVPQRGYHPPSAYYAVSQLRLHGSCLCHGHADRCAPSSRTPASPSSAVQVHEVCVCQHNTAGPNCERCAPFYNNRPWRPAEDQDPHECQRCDCNGHSETCHFDPAVFAASQGAHGGVCDNCRDHTEGRNCERCQLHYFRNRRPGAPIQETCIRCDCSVLGARRDVPCDEETGRCVCLPHVVGPKCDQCAPHHWKLASGRGCEPCACDPHNSLGPQCNQFTGQCACREGFGGLTCRAAAIRQCPDRTYGDAAAGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCDRAPVCVACHPCFQTYDGGLRERALRLAGLRNASAALWPQPGLEDHGLASRMLDAKSKMEQIQATLGDALVTEEEVAQVANAIFSIRRTLQGLQLDLPLEEETLSLPGDLGSLDRSFNRLLVTYQSKREQFEKISSADPSGAFRMLTAAHQRSSQAAQQVSDSSRRLLQLRDSRREAERLEQQVAGGPGAGGPQLAALRLEMASVPDLTPTINQLCGGSREMPCTPGACPGELCPRDNRTACGSRCRGALPRAGGALRTAGQVAEQLRAFSTQLQQTRQMIRAAEEAASQVQSDTQLLETQVSASRSQMEEDVRRTRLLIQQVREFLSDPDTDTATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDVARARRLQAEAEQARSRAHAVEGQVEEVLGALRQGTLALQEAQDTMRGTRRSMRLIQDRVAEVQQVLGPAERLVTSMTQQLGGFRARMEELGRRARQQQAQAAQARQLAEEASKEALNAQEGFERVKQKYAELKDRLDQSSMLGEQGSRILSVKTEAEELFGETMEMMDRMRDMESELLQGSQAIVLRSADLTGLEQRVEQIRNHINGRVLYYATCK", "length": 1120, "header": "tr|A0A3Q1MS19-1|F1MMK1_BOVIN Computationally mapped isoform of Laminin subunit beta 3 OS=Bos taurus OX=9913 GN=LAMB3 PE=4 SV=2 CANONICAL=F1MMK1-1" }, "locus": { "chromosome": "16", "start_pos": 73712004, "end_pos": 73670475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069496.3", "url": "https://www.ensembl.org/id/ENSBTAT00000069496.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000057211.2", "url": "https://www.ensembl.org/id/ENSBTAP00000057211.2" } ] } }, { "isoform_ac": "F1MMK1-1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1/entry", "sequence": { "sequence": "MRPLLLLYFGLPSLLCAQQACSRGACYPPVGDLLIGRTRFLRASSTCGLTKPETYCAQYGEWQMKCCKCDSRVAHNYNSHQVENVVSSSGPTRWWQSQNDVSPVFLQLDLDRKFQLQDIMMDFKGPVPAGLLIERSSDFGKTWQVYQYLAADCGSAFPWVRQGQPQGWQDARCQTLPQRPNGHPNGAKVQLNLMDLASGIPATQSQKIQELGEITNLRVNFTKLAPVPQRGYHPPSAYYAVSQLRLHGSCLCHGHADRCAPSSRTPASPSSAVQVHEVCVCQHNTAGPNCERCAPFYNNRPWRPAEDQDPHECQRCDCNGHSETCHFDPAVFAASQGAHGGVCDNCRDHTEGRNCERCQLHYFRNRRPGAPIQETCIPCECDPDGAVPGAPCDPLTGQCVCKEHVQGERCDLCKPGFTGLTFSNPQGCHRCDCSVLGARRDVPCDEETGRCVCLPHVVGPKCDQCAPHHWKLASGRGCEPCACDPHNSLGPQCNQFTGQCACREGFGGLTCRAAAIRQCPDRTYGDAAAGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCDRAPVCVACHPCFQTYDGGLRERALRLAGLRNASAALWPQPGLEDHGLASRMLDAKSKMEQIQATLGDALVTEEEVAQVANAIFSIRRTLQGLQLDLPLEEETLSLPGDLGSLDRSFNRLLVTYQSKREQFEKISSADPSGAFRMLTAAHQRSSQAAQQVSDSSRRLLQLRDSRREAERLEQQVAGGPGAGGPQLAALRLEMASVPDLTPTINQLCGGSREMPCTPGACPGELCPRDNRTACGSRCRGALPRAGGALRTAGQVAEQLRAFSTQLQQTRQMIRAAEEAASQVQSDTQLLETQVSASRSQMEEDVRRTRLLIQQVREFLSDPDTDTATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDVARARRLQAEAEQARSRAHAVEGQVEEVLGALRQGTLALQEAQDTMRGTRRSMRLIQDRVAEVQQVLGPAERLVTSMTQQLGGFRARMEELGRRARQQQAQAAQARQLAEEASKEALNAQEGFERVKQKYAELKDRLDQSSMLGEQGSRILSVKTEAEELFGETMEMMDRMRDMESELLQGSQAIVLRSADLTGLEQRVEQIRNHINGRVLYYATCK", "length": 1172, "header": "tr|F1MMK1-1|F1MMK1_BOVIN Isoform 1 of Laminin subunit beta 3 OS=Bos taurus OX=9913 GN=LAMB3 PE=4 SV=3 CANONICAL=F1MMK1-1" }, "locus": { "chromosome": "16", "start_pos": 73712004, "end_pos": 73670475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022005.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022005.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022005.6", "url": "https://www.ensembl.org/id/ENSBTAP00000022005.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QGU8-1", "protein_name": "Laminin subunit beta-3", "gene_name": "Lamb3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTALLLLWLALPGLLHAQQDCSRGACYPPVGDLLIGRTQLLRASSTCGMTKPETYCTQYGEWQMKCCKCDSRLPHNYNSHRVENVAPSSGPMRWWQSQNDVNPVSLQLDLDKRMQLQDIMMDFKSPMPAGMLIERSSDFGKTWRVYQYLATDCASTFPQVHQGQPKNWQDVRCQPLPQKPNGRLTGGKIQLNLMDLASGIPASQSRKIQELGDITNLRVNFTKLAPVPRRGAYPPSAYFAVSQLRLHGSCFCHGHANRCAPSPGGPTGRTTAVQVQNVCICQHNTAGPNCERCAPFYNNRPWGPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGTHGGVCDNCRDHTEGKNCERCQLHYFRNRRPGAPIQETCIPCECDPDGAVPGAPCDPLTGQCVCKEYVQGERCDLCKPGFTGLTFANPQGCHRCDCSILGARRDMPCEEESGRCLCLPNVVGPKCDQCAPSYWKLASGRGCEPCACDPRNSLSPQCNQFTGQCPCREGFGGLTCSSAAIRQCPDKTHGDVASGCRACDCNFGGTKGPGCDKASGRCLCRPGVTGPRCDQCQRGYCDRYPVCVACHSCFQTYDMDLQEQSQRLGGLRNTTEGLWTGTGLEDRGLASRLLDAKSKIEQIRQILGGSSVTEQDVAQVANGILSIRRTLQGLQLDLPLEEEMESFSGDLGNLDRSFNRLLLIYQSKKEQFEKLSSADPSGAFRMLTTAYEQSSRAAQQVSDSSSLLSQLRVNRREIEGLESQAGGRGAGGAQLMALHLEMASLPDLTPTINKLCGSSRQAACTPGACPGELCPHDNGTACGSHCMGTLPRARGAFHMAGQVADQLRGFNSQLQQTRQMIRAAEEAASKVQSDAQRLETQVSTSRLQMEEDVQRTRLLIQQVRGFLTDPDTDAATIQEVSEAVLALWLPTDSATVLRKMKEIQAIAARLPNVDLVLSRTKQDIARARRLQAEAEEARSRAQAVEGQVDDVVGNLRQGTVALQEAQDTMQGTGRSLRLIQERVAEVQQVLVPAERLVRGMKEQLSGFWARMERLRHQAQEEQAQAIQAQKLAEGANEQALSAQEGFERLKQKYKELKDRLGQSPMLGEQGSRILSIKTEAEELFGETMEMMDKMKDMESELLRGSQAIMLRSADLSGLEKHVEQIRGYINGRVLYYATCK", "length": 1171 }, "evidence": [ { "id": "F1MMK1", "url": "https://omabrowser.org/oma/group/F1MMK1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V1A2W0-1", "protein_name": "Laminin subunit beta 3", "gene_name": "LAMB3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MESCCQLWLWALFVLLACPQPGVAQSACSHGACYPPGGDLLLGRGQHLTASSTCGLTKPETYCTPHGEWNMRCCKCDSRLPHARNGHRVANMLSSAGRARWWQSQSGMEHVYLQLDLDEKFQLSSIVLDFRSPLPAAMLIERSTDFGKTWEVYQYLASDCAAAFPHIPRGAPESWGDARCQPLQAQHGYPMHGSKVKFSIQDLASTITTSYSQSVNKLGQFTNLRINFTQLPHIMHHNYRSPSSFYAVTEMQVLGSCFCNGHADRCIASRDPHAMVHGRCECQHNTAGPNCGHCAALYNDRPWAPAEDNDPHECQLCNCNGHSASCHFDPEVFHSSGGVSGGVCDDCQHNTEGNNCERCKTNYFRNQRQDLTHPEACQPCECDPDGTVPGSVCDPLSGHCVCKENVQGERCHLCKPGFAQLAHANPLGCRRCACNVLGTRQNVPCDDETGSCSCLPNVVGTDCDQCAAGHWDMASGRGCRPCECNPSGSHSIHCNQFTGQCQCREGFTGRTCSAAQQQVCPDRHFGDVRVGCTECNCDFQGTEDVGCDKSTGHCLCRPGVTGPRCDQCQRDHCSTYPSCEPCHPCFHTYDGDIQRLRLRLQQASLSNSSIGLPGGSHLGLRLSRAQGSVQQAQGILGHSSAAEQGLAQLGSALTAIREQMQGINPNFQFLDVSASLSKELEALNSSLLTISAQYQSKKTQYETSRSTDLSGAFGTIRSAHQTSTNASSLAAAAATLLATSRESRRDAAGLEAAAATQSSKLLALRAQMASSPNLTPTVNKICGGFRAETCTPAQCEGSLCPQDGGMACGDGLSCRGARPLAGGALRVAGKAAGELDSLSARLRETAQLIKTTEASANQIQSNALRLIEQMSITRTQIEGDVRRAQQFIQQVRNFLSDKDTDPATIQEISEFVLSLRLPTDAAAVLRKMNEIQNLATKLQCPEDILAQTAEDIAKAKQLQQEAEQARNRANAVEGNVEEVVGNLRQANTVLLEAQGAIRGSGSSLRFIQERIEEIEAVLGPAEKNVGSVAAQLAVLAEGLPGLQQTAGQNRLRAGDAQQTAAAASEEANGVQQAFQQVKDMYAELKSRQGQSPALGAQGSRVQSIDLEAKALFEETWNMMLRMETLETEIQESNRALVAKSARLSGLQEQVGRIRDAIHKRVTYYESCS", "length": 1168 }, "evidence": [ { "id": "F1MMK1", "url": "https://omabrowser.org/oma/group/F1MMK1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1LPI5-1", "protein_name": "Laminin subunit beta-3", "gene_name": "Lamb3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMTALFLLWLALPGLLCAQQPCSRGACYPPVGDLLIGRTQLLRASSTCGLTKPETYCTQYGQWQMKCCKCDSRLPRNYNSHRVENVVSSSGPMRWWQSQNDVSPVSLQLDLDKRMQLQDIMMDFKGLMPAGMLIERSSDFGKTWRVYQYLATDCASTFPQVHQGQPKNWQDVRCRPLSQRPNGHLTGGKVQLNLMDLASAIPASQSKKIQELGDITNLRVNFTKLAPVPQRGSYPPSAYFAVSQLRLQGSCFCHGHADRCAPNPGGPTGSTTAVQVNDVCVCQHNTAGPNCDRCAPFYNNRPWRPAEGQDIHECQRCDCNGHSETCHFDPAVFAASQGTSGGVCDNCQDHTEGKNCERCQLHYFRNRRPGAPIHETCIPCECDPDGAVPGAPCDRLTGQCVCKDHVQGERCDLCKPGFTGLTFANPQGCHPCDCSILGTRQDMPCEEETGRCLCLPNVVGPKCDQCAPSHWKLASGRGCEPCACDPRNSLSSQCNQFTGQCPCREGFGGLTCSSAAIRQCPDRTHGDVATGCRACDCDFRGTEGPGCDKTSGRCLCRPGLTGPRCDQCQRGYCDRYPVCVACHSCFQAYDTDLQEQAWRLGSLRNTTEGLGTGTGLEDRGLASRLLDAKSKIEQIRQILGGTSVTERDVAQVANAILSIRRTLQGLPLDLPLEEEMESFSGDLGNLDRSFNRLLLMYRSKKEQFEKLSSVDPSGAFRMLTMAYEQSSRAAQQVSDSSSLLSQLRDSRREVEGLERQTGEGGAGGAQLMALRLEMASLPDLTPTINKLCGGSRQTACTPGDCPGLLCPQDNGTACGSHCRGALPRARGALHMAGQVAEQLRSFNTQLQQTRQMIRAAEEAASKVQSDAQRLETQVSTSRLQMEEDVRRTRLLIQQVRGFLTDPHTDAATIQQVSEAVLALWLPTDSATVLRKMKEIQDIAARLPNVDLVLSQTKQDIARARRLQAEAEKARSRAHVVEGQVDDVVGNLRQGTVALQEAQDTMQGTGRSLRLIQERVTEVQQVLVPAERLVKGMKEQMSGFWARVKELRHQAQEEQAQAMKAQQLAEGASNQAMNAQEGFERLKQRYTELKDRLGQSSMLGEQGNRILSIKAEAEELFGETMEMMDKMKDMESELLRGSQAIMLRSADLSGLEKRVEQIRSYINGRVLYYATCK", "length": 1172 }, "evidence": [ { "id": "F1MMK1", "url": "https://omabrowser.org/oma/group/F1MMK1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q13751-1", "protein_name": "Laminin subunit beta-3", "gene_name": "LAMB3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQMKCCKCDSRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRPNARLNGGKVQLNLMDLVSGIPATQSQKIQEVGEITNLRVNFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFGRLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRRTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVALRLEMSSLPDLTPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLRGFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLTDPDTDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARARRLQAEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQVLRPAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFERIKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAIMLRSADLTGLEKRVEQIRDHINGRVLYYATCK", "length": 1172 }, "evidence": [ { "id": "F1MMK1", "url": "https://omabrowser.org/oma/group/F1MMK1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q61087-1", "protein_name": "Laminin subunit beta-3", "gene_name": "Lamb3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTAFFLLWLALPGFLCAQQACSRGACYPPVGDLLIGRTQLLRASSTCGLTKPETYCTQYGQWQMKCCKCDSRLPRNYNSHRVENVASSSGPMRWWQSQNDVSPVSLQLDLDKRMQLQDIMMDFKGLTPAGMLIERSSDFGKTWRVYQYLATDCASTFPQVHQGQPKNWQDVRCRPLSQRPNGHLTGGKVQLNLMDLASAIPASQSKKIQELGDITNLRVNFTKLAPVPQRGSYPPSAYFAVSQLRLQGSCFCHGHADRCAPNPGGSTTAVQVNNVCVCQHNTAGPNCDRCAPFYNNRPWRPAEGQDTHECQRCDCNGHSETCHFDPAVFAASQGTNGGVCDNCRDHTEGKNCERCQLHYFRNRRPSAPIHETCIPCECDPDGAVQGAPCDRLTGQCVCKEYVQGERCDLCKPGFTGLTFANPKGCHACDCSILGARKDMPCEEETGRCLCLPNVVGPKCDQCAPSHWKLASGLGCEPCACDPRNSLSSQCNQFTGQCPCREGFGGLTCSSAAIRQCPDQTYGHVATGCRACDCDFRGTEGPGCDKASGRCLCRPGFTGPRCDQCQRGHCDRYPVCVACHSCFQAYDTDLQEQARRLHSLRNATEGLWTGTGLEDHGLASRLLDAKSKIEQIRQILEGTSVTEQDVAQVANGILSIRRTLQGLPLDLPLEEEMESFSGDLGNLDRSFSRLLLMYRSKKEQFEKLSSEDPSGAFRMLTMAYEQSSRAAQQVSDSSSLLSQLRDSRREAEGLERQAGGGGTGGAQLMALRLEMASLPDLTPTINKLCGRSRQTACTPGDCPGELCPQDNGTACGSHCRGALPRAKGAFHMAGRVAEQLRNFNTQLQQTRQMIRAAEEAASRVQADAQRLETQVSTSRLLMEEDVQRTRLLIQQVRGFLTDPDTDAATIQQVSEAVLALWLPTDSATVLRKMKEIQAIAARLPNVDSVLSQTKQDIARARRLQAEAEQARSRAHAVEGQVDDVVGNLRQGTVALQEAQDTMQGTGRSLRLIQERVGEVQQVLVPAERLVKGMKEQMSGFWARMKELRRQAQEEQAQAMQARQLAEGASQQAMNAQEGFKRLKQKYTELKDRLGQSPVLGEQGNRILSIKMEAEELFGETMEMMDKMKDMESELLRGSQAIMLRSADLSGLEKRVEQIRSYINGRVLYYATCK", "length": 1168 }, "evidence": [ { "id": "F1MMK1", "url": "https://omabrowser.org/oma/group/F1MMK1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ], "pmid": "" }, { "name": "animal organ morphogenesis", "id": "GO:0009887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009887", "evidence": [ { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ], "pmid": "" }, { "name": "substrate adhesion-dependent cell spreading", "id": "GO:0034446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034446", "evidence": [ { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ], "pmid": "" }, { "name": "tissue development", "id": "GO:0009888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009888", "evidence": [ { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ], "pmid": "" }, { "name": "endodermal cell differentiation", "id": "GO:0035987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035987", "evidence": [ { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ], "pmid": "" }, { "name": "basement membrane assembly", "id": "GO:0070831", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070831", "evidence": [ { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ], "pmid": "" }, { "name": "laminin complex", "id": "GO:0043256", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043256", "evidence": [ { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ], "pmid": "" }, { "name": "laminin-5 complex", "id": "GO:0005610", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005610", "evidence": [ { "database": "UniProtKB", "id": "F1MMK1", "url": "https://www.uniprot.org/uniprotkb/F1MMK1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 604, "end_pos": 606, "annotation": "n_glycosylation_sequon" }, { "start_pos": 810, "end_pos": 812, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MMK1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1172, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MMK1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MMK1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 220, "end_pos": 222 }, { "start_pos": 604, "end_pos": 606 }, { "start_pos": 810, "end_pos": 812 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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"XP_010808135", "name": "rhotekin isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808135" }, "gene_names": [ { "name": "RTKN", "type": "recommended", "evidence": [ { "id": "F1MS34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS34" } ] }, { "name": "RTKN", "type": "synonym", "evidence": [ { "id": "XP_010808135", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808135" } ] } ], "protein_names": [ { "name": "Rhotekin", "type": "synonym", "evidence": [ { "id": "F1MS34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS34/entry#names_and_taxonomy" } ] }, { "name": "rhotekin isoform X1", "type": "synonym", "evidence": [ { "id": "XP_010808135", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808135" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MS34", "url": "https://www.uniprot.org/uniprotkb/F1MS34" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RTKN", "url": "https://www.uniprot.org/uniprotkb/F1MS34", "locus": { "chromosome": "11", "start_pos": 10201730, "end_pos": 10187448, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000490", "url": "https://www.ensembl.org/id/ENSBTAG00000000490" } ] } } ], "crossref": [ { "id": "F1MS34", "url": "https://alphafold.ebi.ac.uk/entry/F1MS34", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000490", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000490", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13249", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13249", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539691", "url": "https://www.ncbi.nlm.nih.gov/gene/539691", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012966", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012966", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051364", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051364", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "A0A3Q1MVM4", "url": "https://www.orthodb.org/?gene=A0A3Q1MVM4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21538", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21538", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21538:SF19", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21538:SF19", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00169", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08174", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08174", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-5666185", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5666185", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_010808135", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808135", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVM4", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1MVM4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKC8", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NKC8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RYG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYG2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS34", "url": "https://www.uniprot.org/uniprotkb/F1MS34", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS34-1", "url": "https://www.uniprot.org/uniprotkb/F1MS34-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFSRNHRSRVTVARGSALEMEFKRGRFRLSLLSDPPEDTELQRKLDHEIRMREGACKLLAACSQREQALEATKSLLVCNSRILNYMGELQRRKEAQVLKKTGRRPSDSGPPTERSPCRGQICISDLRIPLMWKDTEYFKNKGDLHRWAVFLLLQIGEHIQDTEMILVDRTLTDISFQNNVLFAEAGPDFELRLELYGACVEEEGALAGAPKRLATKLSSSLGRSSGRRVRASLETAGGSGSSPILLPTPAVGGPRYHLLAHTTLTLAAVQDGFRTHDLTLATPEESPAWLPLYGSMCCRLVAQPLCMTQPTASGTLRVQVRDPEEWKGSGRRQRRARSRRDQRTIENQAGEPRDWVQVHGVLKGTNLFCYRQPEDTDTGDEPLFTIAINKETQVRAGELDQAASWPFTLSISNRYGEEEVTHTLQAESRGALQSWMEALWQLFFDMSQWKQCCDEIMKIETPAPRKPPQVLAKQGSLYHEMAIEPLDDIAAVTDILAQREGARLETPPPWLAVFTDQPALPGPCSPASVAPAPARIHSLPWGRPRTFSLDAVPSDHSPGASRLVAPLPLQRSPRSRGLCSKGPPHTWLQSPV", "length": 592, "header": "tr|F1MS34-1|F1MS34_BOVIN Isoform 1 of Rhotekin OS=Bos taurus OX=9913 GN=RTKN PE=4 SV=2 CANONICAL=F1MS34-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1MVM4-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MVM4/entry", "sequence": { "sequence": "MQDRLHILEDLNMLYIRQMALSLEDTELQRKLDHEIRMREGACKLLAACSQREQALEATKSLLVCNSRILNYMGELQRRKEAQVLKKTGRRPSDSGPPTERSPCRGQICISDLRIPLMWKDTEYFKNKGDLHRWAVFLLLQIGEHIQDTEMILVDRTLTDISFQNNVLFAEAGPDFELRLELYGACVEEEGALAGAPKRLATKLSSSLGRSSGRRVRASLETAGGSGSSPILLPTPAVGGPRYHLLAHTTLTLAAVQDGFRTHDLTLATPEESPAWLPLYGSMCCRLVAQPLCMTQPTASGTLRVQVRDPEEWKGSGRRQRRARSRRDQRTIENQAGEPRDWVQVHGVLKGTNLFCYRQPEDTDTGDEPLFTIAINKETQVRAGELDQAASWPFTLSISNRYGEEEVTHTLQAESRGALQSWMEALWQLFFDMSQWKQCCDEIMKIETPAPRKPPQVLAKQGSLYHEMAIEPLDDIAAVTDILAQREGARLETPPPWLAVFTDQPALPGPCSPASVAPAPARIHSLPWGRPRTFSLDAVPSDHSPGASRLVAPLPLQRSPRSRGLCSKGPPHTWLQSPV", "length": 579, "header": "tr|A0A3Q1MVM4-1|F1MS34_BOVIN Computationally mapped isoform of Rhotekin OS=Bos taurus OX=9913 GN=RTKN PE=4 SV=2 CANONICAL=F1MS34-1" }, "locus": { "chromosome": "11", "start_pos": 10201362, "end_pos": 10189610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000076426.3", "url": "https://www.ensembl.org/id/ENSBTAT00000076426.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000059133.2", "url": "https://www.ensembl.org/id/ENSBTAP00000059133.2" } ] } }, { "isoform_ac": "A0A3Q1NKC8-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC8/entry", "sequence": { "sequence": "MRGSRLTIWDYFSHSSFQPPFLWPKRSTASTVPSLAHYFAQDTELQRKLDHEIRMREGACKLLAACSQREQALEATKSLLVCNSRILNYMGELQRRKEAQVLKKTGRRPSDSGPPTERSPCRGQICISDLRIPLMWKDTEYFKNKGDLHRWAVFLLLQIGEHIQDTEMILVDRTLTDISFQNNVLFAEAGPDFELRLELYGACVEEEGALAGAPKRLATKLSSSLGRSSGRRVRASLETAGGSGSSPILLPTPAVGGPRYHLLAHTTLTLAAVQDGFRTHDLTLATPEESPAWLPLYGSMCCRLVAQPLCMTQPTASGTLRVQQAGEPRDWVQVHGVLKGTNLFCYRQPEDTDTGDEPLFTIAINKETQVRAGELDQAASWPFTLSISNRYGEEEVTHTLQAESRGALQSWMEALWQLFFDMSQWKQCCDEIMKIETPAPRKPPQVLAKQGSLYHEMAIEPLDDIAAVTDILAQREGARLETPPPWLAVFTDQPALPGPCSPASVAPAPARIHSLPWGRPRTFSLDAVPSDHSPGASRLVAPLPLQRSPRSRGLCSKGPPHTWLQSPV", "length": 568, "header": "tr|A0A3Q1NKC8-1|F1MS34_BOVIN Computationally mapped isoform of Rhotekin OS=Bos taurus OX=9913 GN=RTKN PE=4 SV=1 CANONICAL=F1MS34-1" }, "locus": { "chromosome": "11", "start_pos": 10201362, "end_pos": 10188126, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000070076.2", "url": "https://www.ensembl.org/id/ENSBTAT00000070076.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000072782.2", "url": "https://www.ensembl.org/id/ENSBTAP00000072782.2" } ] } }, { "isoform_ac": "A0AAA9RYG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RYG2/entry", "sequence": { "sequence": "MFSRNHRSRVTVARGSALEMEFKRGRFRLSLLSDPPEDTELQRKLDHEIRMREGACKLLAACSQREQALEATKSLLVCNSRILNYMGELQRRKEAQVLKKTGRRPSDSGPPTERSPCRGQICISDLRIPLMWKDTEYFKNKGDLHRWAVFLLLQIGEHIQDTEMILVDRTLTDISFQNNVLFAEAGPDFELRLELYGACVEEEGALAGAPKRLATKLSSSLGRSSGRRVRASLETAGGSGSSPILLPTPAVGGPRYHLLAHTTLTLAAVQDGFRTHDLTLATPEESPAWLPLYGSMCCRLVAQPLCMTQPTASGTLRVQQAGEPRDWVQVHGVLKGTNLFCYRQPEDTDTGDEPLFTIAINKETQVRAGELDQAASWPFTLSISNRYGEEEVTHTLQAESRGALQSWMEALWQLFFDMSQWKQCCDEIMKIETPAPRKPPQVLAKQGSLYHEMVSEPVAPGGPCEGLLLQDNAVSAEIRALLSSSYTDR", "length": 489, "header": "tr|A0AAA9RYG2-1|F1MS34_BOVIN Computationally mapped isoform of Rhotekin OS=Bos taurus OX=9913 GN=RTKN PE=4 SV=1 CANONICAL=F1MS34-1" }, "locus": { "chromosome": "11", "start_pos": 10200956, "end_pos": 10187533, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108178.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108178.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076302.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076302.1" } ] } }, { "isoform_ac": "F1MS34-1", "url": "https://www.uniprot.org/uniprotkb/F1MS34/entry", "sequence": { "sequence": "MFSRNHRSRVTVARGSALEMEFKRGRFRLSLLSDPPEDTELQRKLDHEIRMREGACKLLAACSQREQALEATKSLLVCNSRILNYMGELQRRKEAQVLKKTGRRPSDSGPPTERSPCRGQICISDLRIPLMWKDTEYFKNKGDLHRWAVFLLLQIGEHIQDTEMILVDRTLTDISFQNNVLFAEAGPDFELRLELYGACVEEEGALAGAPKRLATKLSSSLGRSSGRRVRASLETAGGSGSSPILLPTPAVGGPRYHLLAHTTLTLAAVQDGFRTHDLTLATPEESPAWLPLYGSMCCRLVAQPLCMTQPTASGTLRVQVRDPEEWKGSGRRQRRARSRRDQRTIENQAGEPRDWVQVHGVLKGTNLFCYRQPEDTDTGDEPLFTIAINKETQVRAGELDQAASWPFTLSISNRYGEEEVTHTLQAESRGALQSWMEALWQLFFDMSQWKQCCDEIMKIETPAPRKPPQVLAKQGSLYHEMAIEPLDDIAAVTDILAQREGARLETPPPWLAVFTDQPALPGPCSPASVAPAPARIHSLPWGRPRTFSLDAVPSDHSPGASRLVAPLPLQRSPRSRGLCSKGPPHTWLQSPV", "length": 592, "header": "tr|F1MS34-1|F1MS34_BOVIN Isoform 1 of Rhotekin OS=Bos taurus OX=9913 GN=RTKN PE=4 SV=2 CANONICAL=F1MS34-1" }, "locus": { "chromosome": "11", "start_pos": 10201362, "end_pos": 10187533, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000619.6", "url": "https://www.ensembl.org/id/ENSBTAT00000000619.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000619.4", "url": "https://www.ensembl.org/id/ENSBTAP00000000619.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 11, "start_aa": "Thr", "end_pos": 11, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr11", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-5666185", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5666185", "resource": "Reactome", "description": "RHO GTPases Activate Rhotekin and Rhophilins" }, { "id": "R-BTA-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-BTA-9013106", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013106", "resource": "Reactome", "description": "RHOC GTPase cycle" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1MS34", "url": "https://www.uniprot.org/uniprotkb/F1MS34" } ], "pmid": "" }, { "name": "Rho protein signal transduction", "id": "GO:0007266", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007266", "evidence": [ { "database": "UniProtKB", "id": "F1MS34", "url": "https://www.uniprot.org/uniprotkb/F1MS34" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "F1MS34", "url": "https://www.uniprot.org/uniprotkb/F1MS34" } ], "pmid": "" }, { "name": "mitotic cytokinesis", "id": "GO:0000281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000281", "evidence": [ { "database": "UniProtKB", "id": "F1MS34", "url": "https://www.uniprot.org/uniprotkb/F1MS34" } ], "pmid": "" }, { "name": "actomyosin contractile ring assembly", "id": "GO:0000915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000915", "evidence": [ { "database": "UniProtKB", "id": "F1MS34", "url": "https://www.uniprot.org/uniprotkb/F1MS34" } ], "pmid": "" }, { "name": "septin ring organization", "id": "GO:0031106", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031106", "evidence": [ { "database": "UniProtKB", "id": "F1MS34", "url": "https://www.uniprot.org/uniprotkb/F1MS34" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase inhibitor activity", "id": "GO:0005095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005095", "evidence": [ { "database": "UniProtKB", "id": "F1MS34", "url": "https://www.uniprot.org/uniprotkb/F1MS34" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "F1MS34", "url": "https://www.uniprot.org/uniprotkb/F1MS34" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "actomyosin contractile ring", "id": "GO:0005826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005826", "evidence": [ { "database": "UniProtKB", "id": "F1MS34", "url": "https://www.uniprot.org/uniprotkb/F1MS34" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MS34-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 592, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MS34-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MS34" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MS34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS34" }, { "id": "PS51860", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51860" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "REM-1", "eco_id": "ECO_0000259", "start_pos": 17, "end_pos": 98, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 11 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MKC7-1", "uniprot_ac": "F1MKC7", "uniprot_id": "F1MKC7_BOVIN", "mass": { "chemical_mass": 217304.0, "monoisotopic_mass": 217304.0 }, "refseq": { "ac": "XP_024836899", "name": "probable helicase with zinc finger domain isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836899" }, "gene_names": [ { "name": "HELZ", "type": "recommended", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "name": "HELZ", "type": "synonym", "evidence": [ { "id": "XP_024836899", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836899" } ] } ], "protein_names": [ { "name": "ATP-dependent RNA helicase with zinc finger domain", "type": "recommended", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7/entry#names_and_taxonomy" } ] }, { "name": 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"evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004746", "url": "https://www.ensembl.org/id/ENSBTAG00000004746" } ] } } ], "crossref": [ { "id": "ENSBTAG00000004746", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004746", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18077", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18077", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18808", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18808", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539501", "url": "https://www.ncbi.nlm.nih.gov/gene/539501", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000571", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000571", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": 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"categories": [ "Protein Classification", "Other" ] }, { "id": "PF00642", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00642", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13086", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13086", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13087", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13087", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024836899", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836899", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A3Q1N2G2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2G2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N2G2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2G2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKC7", "url": "https://www.uniprot.org/uniprotkb/F1MKC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKC7-1", "url": "https://www.uniprot.org/uniprotkb/F1MKC7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDRRAEKSCEQACESLKRQDYEMALQHCTEALLSLGQYSMADFTGPCPLEIESIKIESLLYRIASFLQLKNYGQADEDCRHVLGEGLAKGDGAFQAVLCCMQLKGKLQPVSHILAKSLTGESLNGMVTKDLTRLKTLLKETETATSNVLSGYHVEDLEEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLIEKWMNSLSPEKVLSECVEGVKVEHDPGLSVTVNTKKSHQTWTFALTCKPARMLCRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAPNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIVDFEPNETTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKTNYQSRLHDLLYIEEIAQYKEVSKFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKEKLVQTQGTKEKVYEATIEEKTKEYIFLRISRECCEELNLRPDYDTQVELQFQLNRLPLCEMHYALDRVKDNGVLFPDITMAPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLSIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETSRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATRHTRVVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKEFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENNSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRAQHAGNTNKPQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPVPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVSIGQPQNQHQEKDQHEQSRNGKSDTNNPGPEINKIRTPEKKPTEAKQIDLESNPQNRSPESRSGIVYPHPKFHRKDNLTPRHINLPLPAPHAQYAIPGRHFHPLPQLPRPPFPIPQQHALLNQQQSNLPEQPSPVPAQPSQVAPQLGPPPPQLSPAYPAGPGSAFFNNAVPHRPQSPPAEAVVPEQQPPPVLQEGHSPLRALAQPGPILPSPLNSFPDESPPGLPMGEALDRMHGSVALETLRQQHVRLQQWSEHHAYLSQGSLPYPHHHHPHPHLQHLPQPPVGLHQPPVRADWKLPSSAEDEAETTDSRFQDLLRELSNREQSETRELAEMPPPQSRLLQYRQIQTRSPPAAPSPPSGADHSTHFPNFTDSSRDLEVANSPAFPQRLPPPMFSSPFSLPSEHLTPPLKYLAPDGAWTFANLQQNHLMGPSFPYGLPPLPHRPPQNPFVQMQTHQPAVGQEPLQPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEASTPQDSLAQRKELQDHNNQSSFTFSSPESWVNATSSTPYQNIPCNGSSRPAQPRELAAPPKTVKAPEEHLKPESLEGSSSFNYSVLQHLGQFPPLMPNKQIAESASSSSPQSSGGGKPAMSYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSAGSNGFYSYFK", "length": 1937, "header": "tr|F1MKC7-1|F1MKC7_BOVIN Isoform 1 of ATP-dependent RNA helicase with zinc finger domain OS=Bos taurus OX=9913 GN=HELZ PE=3 SV=4 CANONICAL=F1MKC7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N2G2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N2G2/entry", "sequence": { "sequence": "MSIESNGMVTKDLTRLKTLLKETETATSNVLSGYHVEDLEEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLIEKWMNSLSPEKVLSECVEGVKVEHDPGLSVTVNTKKSHQTWTFALTCKPARMLCRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAPNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIVDFEPNETTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKTNYQSRLHDLLYIEEIAQYKEVSKFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKEKLVQTQGTKEKVYEATIEEKTKEYIFLRISRECCEELNLRPDYDTQVELQFQLNRLPLCEMHYALDRVKDNGVLFPDITMAPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLSIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETSRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATRHTRVVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKEFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENNSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRAQHAGNTNKPQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPVPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVSIGQPQNQHQEKDQHEQSRNGKSDTNNPGPEINKIRTPEKKPTEAKQIDLESNPQNRSPESRSGIVYPHPKFHRKDNLTPRHINLPLPAPHAQYAIPGRHFHPLPQLPRPPFPIPQQHALLNQQQSNLPEQPSPVPAQPSQVAPQLGPPPPQLSPAYPAGPGSAFFNNAVPHRPQSPPAEAVVPEQQPPPVLQEGHSPLRALAQPGPILPSPLNSFPDESPPGLPMGEALDRMHGSVALETLRQQHVRLQQWSEHHAYLSQGSLPYPHHHHPHPHLQHLPQPPVGLHQPPVRADWKLPSSAEDEAETTDSRFQDLLRELSNREQSETRELAEMPPPQSRLLQYRQIQTRSPPAAPSPPSGADHSTHFPNFTDSSRDLEVANSPAFPQRLPPPMFSSPFSLPSEHLTPPLKYLAPDGAWTFANLQQNHLMGPSFPYGLPPLPHRPPQNPFVQMQTHQPAVGQEPLQPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEASTPQDSLAQRKELQDHNNQSSFTFSSPESWVNATSSTPYQNIPCNGSSRPAQPRELAAPPKTVKAPEEHLKPESLEGSSSFNYSVLQHLGQFPPLMPNKQIAESASSSSPQSSGGGKPAMSYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSAGSNGFYSYFK", "length": 1818, "header": "tr|A0A3Q1N2G2-1|F1MKC7_BOVIN Computationally mapped isoform of ATP-dependent RNA helicase with zinc finger domain OS=Bos taurus OX=9913 GN=HELZ PE=3 SV=1 CANONICAL=F1MKC7-1" }, "locus": { "chromosome": "19", "start_pos": 63251680, "end_pos": 63147957, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000068831.2", "url": "https://www.ensembl.org/id/ENSBTAT00000068831.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000063455.2", "url": "https://www.ensembl.org/id/ENSBTAP00000063455.2" } ] } }, { "isoform_ac": "F1MKC7-1", "url": "https://www.uniprot.org/uniprotkb/F1MKC7/entry", "sequence": { "sequence": "MEDRRAEKSCEQACESLKRQDYEMALQHCTEALLSLGQYSMADFTGPCPLEIESIKIESLLYRIASFLQLKNYGQADEDCRHVLGEGLAKGDGAFQAVLCCMQLKGKLQPVSHILAKSLTGESLNGMVTKDLTRLKTLLKETETATSNVLSGYHVEDLEEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLIEKWMNSLSPEKVLSECVEGVKVEHDPGLSVTVNTKKSHQTWTFALTCKPARMLCRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAPNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIVDFEPNETTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKTNYQSRLHDLLYIEEIAQYKEVSKFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKEKLVQTQGTKEKVYEATIEEKTKEYIFLRISRECCEELNLRPDYDTQVELQFQLNRLPLCEMHYALDRVKDNGVLFPDITMAPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLSIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETSRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATRHTRVVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKEFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENNSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRAQHAGNTNKPQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPVPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVSIGQPQNQHQEKDQHEQSRNGKSDTNNPGPEINKIRTPEKKPTEAKQIDLESNPQNRSPESRSGIVYPHPKFHRKDNLTPRHINLPLPAPHAQYAIPGRHFHPLPQLPRPPFPIPQQHALLNQQQSNLPEQPSPVPAQPSQVAPQLGPPPPQLSPAYPAGPGSAFFNNAVPHRPQSPPAEAVVPEQQPPPVLQEGHSPLRALAQPGPILPSPLNSFPDESPPGLPMGEALDRMHGSVALETLRQQHVRLQQWSEHHAYLSQGSLPYPHHHHPHPHLQHLPQPPVGLHQPPVRADWKLPSSAEDEAETTDSRFQDLLRELSNREQSETRELAEMPPPQSRLLQYRQIQTRSPPAAPSPPSGADHSTHFPNFTDSSRDLEVANSPAFPQRLPPPMFSSPFSLPSEHLTPPLKYLAPDGAWTFANLQQNHLMGPSFPYGLPPLPHRPPQNPFVQMQTHQPAVGQEPLQPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEASTPQDSLAQRKELQDHNNQSSFTFSSPESWVNATSSTPYQNIPCNGSSRPAQPRELAAPPKTVKAPEEHLKPESLEGSSSFNYSVLQHLGQFPPLMPNKQIAESASSSSPQSSGGGKPAMSYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSAGSNGFYSYFK", "length": 1937, "header": "tr|F1MKC7-1|F1MKC7_BOVIN Isoform 1 of ATP-dependent RNA helicase with zinc finger domain OS=Bos taurus OX=9913 GN=HELZ PE=3 SV=4 CANONICAL=F1MKC7-1" }, "locus": { "chromosome": "19", "start_pos": 63272123, "end_pos": 63147957, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006233.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006233.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006233.7", "url": "https://www.ensembl.org/id/ENSBTAP00000006233.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "bta:539501", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:539501", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MKC7", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MKC7", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "F1MKC7", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ], "pmid": "" }, { "name": "helicase activity", "id": "GO:0004386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "database": "UniProtKB", "id": "F1MKC7", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ], "pmid": "" }, { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1MKC7", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MKC7", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MKC7", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ], "pmid": "" }, { "name": "P granule", "id": "GO:0043186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043186", "evidence": [ { "database": "UniProtKB", "id": "F1MKC7", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulatory ncRNA-mediated post-transcriptional gene silencing", "id": "GO:0035194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035194", "evidence": [ { "database": "UniProtKB", "id": "F1MKC7", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1075, "end_pos": 1077, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1316, "end_pos": 1318, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1337, "end_pos": 1339, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1629, "end_pos": 1631, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1787, "end_pos": 1789, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1801, "end_pos": 1803, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1814, "end_pos": 1816, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1851, "end_pos": 1853, "annotation": "n_glycosylation_sequon" }, { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 774, "end_pos": 776, "annotation": "n_glycosylation_sequon" }, { "start_pos": 875, "end_pos": 877, "annotation": "n_glycosylation_sequon" }, { "start_pos": 915, "end_pos": 917, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AAA9S5G9-1", "F1MWZ4-1", "A0AAA9SX42-1", "A0AAA9RXI8-1", "A0AAF6DLT1-1", "A6QLE5-1", "F1MSG2-1", "F6QYF9-1", "A0A3Q1MR04-1", "Q05B79-1", "E1BDN4-1", "A0AAA9U2H6-1", "A0AAA9TGZ3-1", "A4K436-1", "Q5E9H5-1", "A0A3Q1LTL4-1", "A6QLJ0-1", "A0A3Q1LSH0-1", "Q3SZ54-1", "A0AAF6Z0U5-1", "F1N079-1", "F6R6W2-1", "A0A3Q1MR43-1", "A0AAA9TT64-1", "Q0V8H6-1", "A0AAF6Z733-1", "Q2KJI7-1", "P09487-1", "P19120-1", "Q0IIK5-1", "A0AAF6YVB0-1", "Q2KIZ8-1", "P63258-1", "A1A4H6-1", "A7YSY2-1", "A0A3Q1LG16-1", "A0AAA9RUK3-1", "Q1RMT1-1", "G3X757-1", "F1MN01-1", "A0AAA9TT27-1", "A0ABI0NX25-1", "F1MB25-1", "F1MEM4-1", "A0A3Q1M0A4-1", "A0A3Q1MU57-1", "A5D7C1-1", "A0AAA9SPF3-1", "A0A3Q1M155-1", "E1BAN8-1", "A0A3Q1MS44-1", "F1MSD2-1", "O18956-1", "Q76LV2-1", "A4FUD9-1", "A5PJA1-1", "A6QQR4-1", "Q32LC7-1", "Q3ZBT1-1", "Q3ZC07-1", "Q5W5U4-1", "E1B9N7-1", "G3N268-1", "E1BKM5-1", "P35071-1", "P60712-1", "P62739-1", "P68138-1", "Q0V8B7-1", "Q0VD48-1", "Q17R09-1", "Q29S22-1", "Q2NKY8-1", "Q2TBU9-1", "Q3B7N1-1", "Q0VCX2-1", "Q28141-1", "Q2NL22-1", "Q3T147-1", "Q3ZBH9-1", "Q3ZBV2-1", "Q3ZC91-1", "Q5E9B5-1", "Q5E9N5-1", "Q1LZ78-1", "E1BH89-1", "F1MNU7-1", "A0ABI0NSA6-1", "F1N533-1", "Q2NL08-1", "E1BF68-1", "F1MW45-1", "F1N272-1", "Q2TBP1-1", "Q3SZ40-1", "Q3SZ65-1", "A0AAA9RRF7-1", "A0ABI0P467-1", "A5PJI5-1", "A0AAA9T674-1", "Q95M18-1", "Q3ZCH0-1", "F1MMS0-1", "E1BH78-1", "A0ABI0P3F2-1", "A0AAF6DLQ5-1", "G3MYF0-1", "A0A3Q1LQN7-1", "A0ABI0NXS3-1", "A0A3Q1M7R9-1", "A0A3Q1LT80-1", "Q9TTA5-1", "Q3ZBH0-1", "Q2HJF8-1", "Q2NKZ1-1", "Q2T9X2-1", "Q32L40-1", "A7Z019-1", "F6QHI8-1", "E1BDM8-1", "E1BNG3-1", "E1BP01-1", "F1MRW7-1", "A0A3Q1LV49-1", "F1MWM0-1", "Q3MHL7-1", "Q3T0K2-1", "Q5E9M9-1", "Q3ZCI9-1", "F1MYC6-1", "F1MUT6-1", "A0A3Q1M493-1", "A0A3Q1LXD0-1", "F1N155-1", "E1BII7-1", "E1BPG1-1", "F1MMK3-1", "F1MSI6-1", "F1N1A2-1", "A0A3Q1NMG4-1", "A0AAA9STQ6-1", "A0AAA9T2L7-1", "F1MMD5-1", "A0A3Q1LQC3-1", "A0AAA9T8W7-1", "E1B887-1", "F1MLB2-1", "E1BPX4-1", "F1N2W9-1", "E1BB03-1", "E1BMP7-1", "A0JND9-1", "E1BAS6-1", "A0AAA9RXM7-1", "Q59HJ6-1", "Q2KJ94-1", "A0A3Q1MDD8-1", "G3X6Y8-1", "A0AAF6Z0E4-1", "G3MZH7-1", "F1MKC7-1", "A0AAA9S7V9-1", "A0AAF6YME1-1", "F1MFR1-1", "Q3T084-1", "E1B7X9-1", "A0ABI0P204-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LG16", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LG16", "database": "UniProtKB", "url": 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"uniprot_ac": "A0A3Q1LXD0", "gene_name": "DDX49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A3Q1LXD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LXD0" } ] } ] }, { "uniprot_ac": "A0A3Q1M0A4", "gene_name": "ATP13A5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A0A3Q1M0A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M0A4" } ] } ] }, { "uniprot_ac": "A0A3Q1M155", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A3Q1M155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M155" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": 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"id": "A0AAA9SPF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPF3" } ] } ] }, { "uniprot_ac": "A0AAA9STQ6", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9STQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9STQ6" } ] } ] }, { "uniprot_ac": "A0AAA9SX42", "gene_name": "TDRD12", "activity": [ { "ec_number": 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"activity": "", "evidence": [ { "id": "A0AAA9TT64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TT64" } ] } ] }, { "uniprot_ac": "A0AAA9U2H6", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0AAA9U2H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U2H6" } ] } ] }, { "uniprot_ac": "A0AAF6DLQ5", "gene_name": "MTREX", 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] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B9N7", "gene_name": "DHX29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1B9N7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9N7" } ] } ] }, { "uniprot_ac": "E1BAN8", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] }, { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "E1BB03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB03" } ] } ] }, { "uniprot_ac": "E1BDM8", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDM8" } ] } ] }, { "uniprot_ac": "E1BDN4", "gene_name": "DHX35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BDN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDN4" } ] } ] }, { "uniprot_ac": "E1BF68", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BF68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BF68" } ] } ] }, { "uniprot_ac": "E1BH78", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BH78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH78" } ] } ] }, { "uniprot_ac": "E1BH89", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E1BH89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH89" } ] } ] }, { "uniprot_ac": "E1BII7", "gene_name": "DDX43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E1BII7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BII7" } ] } ] }, { "uniprot_ac": "E1BKM5", "gene_name": "RECQL5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BKM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKM5" } ] } ] }, { "uniprot_ac": "E1BMP7", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] }, { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BMP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMP7" } ] } ] }, { "uniprot_ac": "E1BNG3", "gene_name": "ascc3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BNG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNG3" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BPG1", "gene_name": "ZGRF1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "E1BPG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPG1" } ] } ] }, { "uniprot_ac": "E1BPX4", "gene_name": "MCM8", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "E1BPX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPX4" } ] } ] }, { "uniprot_ac": "F1MB25", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "F1MB25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MB25" } ] } ] }, { "uniprot_ac": "F1MEM4", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MEM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MEM4" } ] } ] }, { "uniprot_ac": "F1MFR1", "gene_name": "HFM1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MFR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFR1" } ] } ] }, { "uniprot_ac": "F1MKC7", "gene_name": "HELZ", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC7" } ] } ] }, { "uniprot_ac": "F1MLB2", "gene_name": "CHD8", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F1MLB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLB2" } ] } ] }, { "uniprot_ac": "F1MMD5", "gene_name": "XRCC6", "activity": [ { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "4.2.99.18", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MMD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMD5" } ] } ] }, { "uniprot_ac": "F1MMK3", "gene_name": "DDX50", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MMK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK3" } ] } ] }, { "uniprot_ac": "F1MMS0", "gene_name": "BRIP1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction.", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "F1MMS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMS0" } ] } ] }, { "uniprot_ac": "F1MN01", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1MN01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN01" } ] } ] }, { "uniprot_ac": "F1MNU7", "gene_name": "YTHDC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MNU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNU7" } ] } ] }, { "uniprot_ac": "F1MRW7", "gene_name": "DDX20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MRW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRW7" } ] } ] }, { "uniprot_ac": "F1MSD2", "gene_name": "RUVBL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1MSD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSD2" } ] } ] }, { "uniprot_ac": "F1MSG2", "gene_name": "FBH1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1MSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG2" } ] } ] }, { "uniprot_ac": "F1MSI6", "gene_name": "DDX25", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MSI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI6" } ] } ] }, { "uniprot_ac": "F1MUT6", "gene_name": "DDX19B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MUT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUT6" } ] } ] }, { "uniprot_ac": "F1MW45", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MW45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MW45" } ] } ] }, { "uniprot_ac": "F1MWM0", "gene_name": "ABCA4", "activity": [ { "ec_number": "7.6.2.1", "activity": "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] }, { "ec_number": "7.6.2.1", "activity": "", "evidence": [ { "id": "F1MWM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWM0" } ] } ] }, { "uniprot_ac": "F1MWZ4", "gene_name": "DHX33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWZ4" } ] } ] }, { "uniprot_ac": "F1MYC6", "gene_name": "DDX4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MYC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYC6" } ] } ] }, { "uniprot_ac": "F1N079", "gene_name": "RTEL1", "activity": [ { "ec_number": "5.6.2.-", "activity": "", "evidence": [ { "id": "F1N079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N079" } ] } ] }, { "uniprot_ac": "F1N155", "gene_name": "CLPX", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "F1N155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N155" } ] } ] }, { "uniprot_ac": "F1N1A2", "gene_name": "DHX57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N1A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N1A2" } ] } ] }, { "uniprot_ac": "F1N272", "gene_name": "ATP13A4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1N272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N272" } ] } ] }, { "uniprot_ac": "F1N2W9", "gene_name": "MCM9", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1N2W9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2W9" } ] } ] }, { "uniprot_ac": "F1N533", "gene_name": "DDX18", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1N533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N533" } ] } ] }, { "uniprot_ac": "F6QHI8", "gene_name": "DDX21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QHI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QHI8" } ] } ] }, { "uniprot_ac": "F6QYF9", "gene_name": "DDX41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6QYF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QYF9" } ] } ] }, { "uniprot_ac": "F6R6W2", "gene_name": "DDX23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F6R6W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6R6W2" } ] } ] }, { "uniprot_ac": "G3MYF0", "gene_name": "DDX53", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3MYF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MYF0" } ] } ] }, { "uniprot_ac": "G3MZH7", "gene_name": "ENTPD2", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 phosphate + 2 H(+).", "evidence": [ { "id": "G3MZH7", "database": "UniProtKB", "url": 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"https://www.uniprot.org/uniprotkb/O18956" } ] } ] }, { "uniprot_ac": "P09487", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P09487" } ] } ] }, { "uniprot_ac": "P19120", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P19120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P19120" } ] } ] }, { "uniprot_ac": "P35071", "gene_name": "CFTR", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P35071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35071" } ] } ] }, { "uniprot_ac": "P60712", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P60712" } ] } ] }, { "uniprot_ac": "P62739", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62739" } ] } ] }, { "uniprot_ac": "P63258", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63258", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P63258" } ] } ] }, { "uniprot_ac": "P68138", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68138" } ] } ] }, { "uniprot_ac": "Q05B79", "gene_name": "DHX36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q05B79" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05B79", "database": "UniProtKB", "url": 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+ phosphate + H(+).", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA.", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] }, { "ec_number": "5.6.2.5", "activity": "", "evidence": [ { "id": "Q0V8H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V8H6" } ] } ] }, { "uniprot_ac": "Q0VCX2", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q0VCX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VCX2" } ] } ] }, { "uniprot_ac": "Q0VD48", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q0VD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD48" } ] } ] }, { "uniprot_ac": "Q17R09", "gene_name": "DHX38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q17R09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R09" } ] } ] }, { "uniprot_ac": "Q1LZ78", "gene_name": "NTPCR", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "Q1LZ78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LZ78" } ] } ] }, { "uniprot_ac": "Q1RMT1", "gene_name": "ERCC3", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q1RMT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT1" } ] } ] }, { "uniprot_ac": "Q28141", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q28141", "database": 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H(+).", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q2KIZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIZ8" } ] } ] }, { "uniprot_ac": "Q2KJ94", "gene_name": "RAD51", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q2KJ94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJ94" } ] } ] }, { "uniprot_ac": "Q2KJI7", "gene_name": "AFG3L2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] }, { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q2KJI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJI7" } ] } ] }, { "uniprot_ac": "Q2NKY8", "gene_name": "DHX30", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NKY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKY8" } ] } ] }, { "uniprot_ac": "Q2NKZ1", "gene_name": "CCT7", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "ATP + H2O + an unfolded polypeptide = ADP + phosphate + a folded polypeptide.", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "Q2NKZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NKZ1" } ] } ] }, { "uniprot_ac": "Q2NL08", "gene_name": "DDX55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL08" } ] } ] }, { "uniprot_ac": "Q2NL22", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q2NL22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2NL22" } ] } ] }, { "uniprot_ac": "Q2T9X2", "gene_name": "CCT4", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "Q2T9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2T9X2" } ] } ] }, { "uniprot_ac": "Q2TBP1", 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"https://www.uniprot.org/uniprotkb/A0A3Q1N6E0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1N6E0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6E0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV91", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV91", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SV91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV91-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP12-1", "url": "https://www.uniprot.org/uniprotkb/F1MP12-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQSDPPGKLPMQPPLNSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGSLSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMTTSNPGLNSPQFAGQQQQFSAKAGPTQPYIQQSMYGRPNYPGSGGFGASYPGGPNAPAGMGVPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPVCSSFQMGPTQAYNSQFMNQPGPRGPASMGGSMNPASMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTYPGPRPQSLPIQSIKRPYPGEPNYGNQQYGPNSQFPTQPGQYPTPNPPRPLTSPNYPGQRMPSQPSTGQYPPPTVNMGQYYKPEQFNGQNNTFSGSSYSNYSQGNVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKRFKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGSTNSNDYSSQGNNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMPNNMATLEKPLSHPMQETMPHAGSSDQPHPSIQQGLHVPHPSSQSGPPLHHSGAPPPPSQPPRQPPQAAPGNHPHSDLTFNPSSALEGQAGAQGASDMPEPSLDLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN", "length": 1072, "header": "tr|F1MP12-1|F1MP12_BOVIN Isoform 1 of Zinc finger MIZ-type containing 1 OS=Bos taurus OX=9913 GN=ZMIZ1 PE=4 SV=3 CANONICAL=F1MP12-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1N6E0-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N6E0/entry", "sequence": { "sequence": "MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQSDPPGKLPMQPPLNSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGSLSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMTTSNPGLNSPQFAGQQQQFSAKAGPTQPYIQQSMYGRPNYPGSGGFGASYPGGPNAPAGMGVPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPVCSSFQMGPTQAYNSQFMNQPGPRGPASMGGSMNPASMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTYPGPRPQSLPIQSIKRPYPGEPNYGNQQYGPNSQFPTQPGQYPTPNPPRPLTSPNYPGQRMPSQPSTGQYPPPTVNMGQYYKPEQFNGQNNTFSGSSYSNYSQGNVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKRFKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGSTNSNDYSSQGNNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMPNNMATLEKPLSHPMQETLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN", "length": 986, "header": "tr|A0A3Q1N6E0-1|F1MP12_BOVIN Computationally mapped isoform of Zinc finger MIZ-type containing 1 OS=Bos taurus OX=9913 GN=ZMIZ1 PE=4 SV=1 CANONICAL=F1MP12-1" }, "locus": { "chromosome": "28", "start_pos": 34941417, "end_pos": 34832385, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000069893.2", "url": "https://www.ensembl.org/id/ENSBTAT00000069893.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000066015.1", "url": "https://www.ensembl.org/id/ENSBTAP00000066015.1" } ] } }, { "isoform_ac": "A0AAA9SV91-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SV91/entry", "sequence": { "sequence": "MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQSDPPGKLPMQPPLNSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGSLSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMTTSNPGLNSPQFAGQQQQFSAKAGPTQPYIQQSMYGRPNYPGSGGFGASYPGGPNAPAGMGVPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPMGPTQAYNSQFMNQPGPRGPASMGGSMNPASMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTYPGPRPQSLPIQSIKRPYPGEPNYGNQQYGPNSQFPTQPGQYPTPNPPRPLTSPNYPGQRMPSQPSTGQYPPPTVNMGQYYKPEQFNGQNNTFSGSSYSNYSQGNVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKRFKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGSTNSNDYSSQGVPPTPSPYAGPACSCKPADTWGCEGPQEKATLGPTIQPGGNNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMPNNMATLEKPLSHPMQETMPHAGSSDQPHPSIQQGLHVPHPSSQSGPPLHHSGAPPPPSQPPRQPPQAAPGNHPHSDLTFNPSSALEGQAGAQGASDMPEPSLDLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN", "length": 1106, "header": "tr|A0AAA9SV91-1|F1MP12_BOVIN Computationally mapped isoform of Zinc finger MIZ-type containing 1 OS=Bos taurus OX=9913 GN=ZMIZ1 PE=4 SV=1 CANONICAL=F1MP12-1" }, "locus": { "chromosome": "28", "start_pos": 34941417, "end_pos": 34832385, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124471.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124471.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090387.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090387.1" } ] } }, { "isoform_ac": "F1MP12-1", "url": "https://www.uniprot.org/uniprotkb/F1MP12/entry", "sequence": { "sequence": "MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQSDPPGKLPMQPPLNSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGSLSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMTTSNPGLNSPQFAGQQQQFSAKAGPTQPYIQQSMYGRPNYPGSGGFGASYPGGPNAPAGMGVPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPVCSSFQMGPTQAYNSQFMNQPGPRGPASMGGSMNPASMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTYPGPRPQSLPIQSIKRPYPGEPNYGNQQYGPNSQFPTQPGQYPTPNPPRPLTSPNYPGQRMPSQPSTGQYPPPTVNMGQYYKPEQFNGQNNTFSGSSYSNYSQGNVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKRFKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGSTNSNDYSSQGNNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMPNNMATLEKPLSHPMQETMPHAGSSDQPHPSIQQGLHVPHPSSQSGPPLHHSGAPPPPSQPPRQPPQAAPGNHPHSDLTFNPSSALEGQAGAQGASDMPEPSLDLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN", "length": 1072, "header": "tr|F1MP12-1|F1MP12_BOVIN Isoform 1 of Zinc finger MIZ-type containing 1 OS=Bos taurus OX=9913 GN=ZMIZ1 PE=4 SV=3 CANONICAL=F1MP12-1" }, "locus": { "chromosome": "28", "start_pos": 34941417, "end_pos": 34832385, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025717.8", "url": "https://www.ensembl.org/id/ENSBTAT00000025717.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025717.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025717.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 230, "start_aa": "Thr", "end_pos": 230, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr230", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 329, "start_aa": "Thr", "end_pos": 329, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr329", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 523, "start_aa": "Thr", "end_pos": 523, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr523", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "D4AE97-1", "protein_name": "Zinc finger, MIZ-type containing 1", "gene_name": "Zmiz1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQNDPPGKLPMQPPLNSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGSLSVVTTVWGVTNTSQSQVLGNPMANASNPMNPGGNPMASGMSTSNPGLNSPQFAGQQQQFSTKAGPAQPYIQPNMYGRPGYPGSGGFGASYPGGPSAPAGMGIPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPVCSSFQMGPTQAYNSQFMNQPGPRGPASMGGSMNPASMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTYPGPRPQSLPIQSIKRSYPGEPNYGNQQYGPNSQFPTQPGQYPTPNPPRPLTSPNYPGQRMPSQPSTGQYPPPTVNMGQYYKPEQFNGQNNTFSSGSSYSSYSQGSVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKRFKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGGTSSNDYSSQGSNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMPNNMAALEKPLSHPMQETMPHAGSSDQPHPSIQQGLHVPHPSSQAGPPLHHSGAPPPSQPPRQPPQAAPSNHPHSDLTFNPSSALEGQAGAQGASDMPEPSLDLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN", "length": 1072 }, "evidence": [ { "id": "F1MP12", "url": "https://omabrowser.org/oma/group/F1MP12/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P1E1-1", "protein_name": "Zinc finger MIZ domain-containing protein 1", "gene_name": "Zmiz1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQNDPPGKLPMQPPLSSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGSLSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMSTSNPGINSPQFAGQQQQFSTKAGPAQPYIQPNMYGRPGYPGSGGFGASYPGGPSAPAGMGIPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPVCSSFQMGPTQAYNSQFMNQPGPRGPASMGGSLNPAGMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTYPGPRPQSLPIQSIKRPYPGEPNYGNQQYGPNSQFPTQPGQYPTPNPPRPLTSPNYPGQRMPSQPSTGQYPPPTVNMGQYYKPEQFNGQNNTFSSGSSYSSYSQGSVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKRFKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGGTSSNDYSSQGNNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMPNNMAALEKPLSHPMQETMPHAGSSDQPHPSIQQGLHVPHPSSQAGPPLHHSGAPPPSQPPRQPPQAAPGNHPHSDLTFNPSSALEGQAGAQGASDMPEPSLDLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN", "length": 1072 }, "evidence": [ { "id": "F1MP12", "url": "https://omabrowser.org/oma/group/F1MP12/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9ULJ6-1", "protein_name": "Zinc finger MIZ domain-containing protein 1", "gene_name": "ZMIZ1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNSMDRHIQQTNDRLQCIKQHLQNPANFHNAATELLDWCGDPRAFQRPFEQSLMGCLTVVSRVAAQQGFDLDLGYRLLAVCAANRDKFTPKSAALLSSWCEELGRLLLLRHQKSRQSDPPGKLPMQPPLSSMSSMKPTLSHSDGSFPYDSVPWQQNTNQPPGSLSVVTTVWGVTNTSQSQVLGNPMANANNPMNPGGNPMASGMTTSNPGLNSPQFAGQQQQFSAKAGPAQPYIQQSMYGRPNYPGSGGFGASYPGGPNAPAGMGIPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKDINQYGPMGPTQAYNSQFMNQPGPRGPASMGGSMNPASMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTYPGPRPQSLPIQNIKRPYPGEPNYGNQQYGPNSQFPTQPGQYPAPNPPRPLTSPNYPGQRMPSQPSSGQYPPPTVNMGQYYKPEQFNGQNNTFSGSSYSNYSQGNVNRPPRPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPPPANHNDELRLTFPVRDGVVLEPFRLEHNLAVSNHVFHLRPTVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERGDNKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCITKIKRNFSSVAASSGNTTLNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQHSEFEEVTIDPTCSWRPVPIKSDLHIKDDPDGIPSKRFKTMSPSQMIMPNVMEMIAALGPGPSPYPLPPPPGGTNSNDYSSQGNNYQGHGNFDFPHGNPGGTSMNDFMHGPPQLSHPPDMPNNMAALEKPLSHPMQETMPHAGSSDQPHPSIQQGLHVPHPSSQSGPPLHHSGAPPPPPSQPPRQPPQAAPSSHPHSDLTFNPSSALEGQAGAQGASDMPEPSLDLLPELTNPDELLSYLDPPDLPSNSNDDLLSLFENN", "length": 1067 }, "evidence": [ { "id": "F1MP12", "url": "https://omabrowser.org/oma/group/F1MP12/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" }, { "name": "SMAD binding", "id": "GO:0046332", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046332", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" }, { "name": "SUMO ligase activity", "id": "GO:0061665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061665", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" }, { "name": "transforming growth factor beta receptor signaling pathway", "id": "GO:0007179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007179", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" }, { "name": "positive regulation of Notch signaling pathway", "id": "GO:0045747", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045747", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" }, { "name": "SMAD protein signal transduction", "id": "GO:0060395", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060395", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" }, { "name": "androgen receptor signaling pathway", "id": "GO:0030521", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030521", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" }, { "name": "pyramidal neuron migration to cerebral cortex", "id": "GO:0021852", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021852", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" }, { "name": "positive regulation of T cell differentiation", "id": "GO:0045582", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045582", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" }, { "name": "protein sumoylation", "id": "GO:0016925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016925", "evidence": [ { "database": "UniProtKB", "id": "F1MP12", "url": "https://www.uniprot.org/uniprotkb/F1MP12" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 485, "end_pos": 487, "annotation": "n_glycosylation_sequon" }, { "start_pos": 495, "end_pos": 497, "annotation": "n_glycosylation_sequon" }, { "start_pos": 553, "end_pos": 555, "annotation": "n_glycosylation_sequon" }, { "start_pos": 639, "end_pos": 641, "annotation": "n_glycosylation_sequon" }, { "start_pos": 650, "end_pos": 652, "annotation": "n_glycosylation_sequon" }, { "start_pos": 718, "end_pos": 720, "annotation": "n_glycosylation_sequon" }, { "start_pos": 728, "end_pos": 730, "annotation": "n_glycosylation_sequon" }, { "start_pos": 791, "end_pos": 793, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MP12-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1072, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MP12-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MP12" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MP12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP12" }, { "id": "PS51044", "database": "PROSITE", "url": 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"InterPro", "categories": [ "Protein Classification" ] }, { "id": "PTHR14492", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14492", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14492:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14492:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15392", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15392", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_059734876", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734876", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBG2", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A3Q1NBG2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBG2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRT7", "url": 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"MEIRLEVLTSTSIKHKKPWPRVSWLGQENEAVFLLDDKSVNEINLLSGRTKKKIPSLQPLLKDVTLLTTSSNDAWLAGVLTTGEVFLWNKDQDCLKTIPATEKPKDMIKAAVASSSRLYLYVSGNGKRVLLMTPSGCIFLWEHLEFKNGLSSKSLSLVGQWSQIMPEEAVPLPSTEDKEAVVHAVFIKNELFGDCCLCSFTFYSGECLKLTFLAIRWHENVFTPVRSLSYHVQWAQQDCLLCSLIPKCESVKSRGALISAFSRDGLTLAVTLNQKDPKATQVLFINTLNFVTLYGSLKGCSNKNPVVPATLVRSYWVGDVSWTHDSLLLACVLKRGSLVLLTCHGELLTLITFGCSIEFGPAEFIPLHPLITYRPQQFTLQDSNNSVDSSASDSDPMRQRFSIKAHSRLPYLIISDGYMVTTLRFLDNLSPSVLMRSLLLDSTQRLEKTYESVILCKPKGKGLNLRSLNSLRSSLLKHQRNENVADSTVPKFLQAEETLKLNEETADLQDFEAEETDDGRCFPNNLFSFWNQKNDLLFSSVEEGRLEFASMFDTVHAKDNTEETDKTVIELHSVQKNLLAAWTIGISKNVAEKNLMLNYTVVCITHFLYILQFIKCPFPKLDLFLSKSSKHNTWVLCIFQLFHQCLSIQYWDMRYKQDVGHLVKLTSNTIKLLLTQQQQDQLFSEKLLACFHLLRMVADHLNGVYSLQPEVISASADGSRRAKQDSLVLPIFQMFQDSESWENWSWNSSFKIHPQVLNFVQQPGHRLIVLWRILYRKTLWYQMQLSQRVPEDGVQLTEKMTRETSAVKSLLCHIQAELQTAGVRLNQTLELKSINGEECFLLGSYEKSVQIWKKALQETCEKGGRRTCFLQLRYYLSLLYCHLYNYNLNDAQGLCDQLVREILRWSHLPVKENEDCSVPEKSPCESGVTGSVHPEAAVRVVQSMARFMAAYFTNQLLCILPPHSVNVLPPLHIKTEQPFRLIPLQHSKVASAVREQNLSDVWTVEYALELLLIGGLVPEAVWLAHKLGDWKTSVSVGVAFQLFCKHGSKFTRSKEKSLNLPLNMTPAQIFQEKLQCFLGQPASLEAKNEMNSKCKQFTDPIEEEDADLLFASVQEILKAAVMADADILSGTFQLLINSAKDFSKRLWGLVPVGLYLPAPPLYCPQPAVLSEEDGDDLLLKAEKDNRQKVSGILQRILLLFRAARCSFPVAQWYILQLRWARKVMQKIRMKGSLPSLSPFPESLLNYCKGGVAFFRPGAAGDRKLDEASIKAIGCFRELCALCWMLHVRDKLSCSCRQYQKARENVEEKKDLEAKFDPCLVEHCLSAVEWAYRMLPFSRFSNIEELIQDLILSLIAELPPIRKVAEIFVKAFPNPEDIRVSLREKYHSLQQRLRHCVVKGSQTEEMMSVIMHSIHKVRVKALKRVQRNIGSFEMNIWEPVEEEKPAEVAGSDRFSLGTSLSRSTLTELGSSLAHSDADTADTLSEALSAEEKSRTHFCQRSAPNHMELTLTGKPKGKKKIYNQKENPKRKEDCEKLLQNALPVIGVWEFERDDDEYIKFLELFLSYVLERDLLGSKDAGIPFLTSFSGHLRERELNSLLFDVHTTLKRRHSRTKSQNVFRAGSCFVVAPESDECEKSENQSLSASVLANQGIRHFSENPLNEVNKNEGKSGLFGLKQKSVYRIPDDNAEKTLIQRLSNHSVCIPQSTETRRCAFKAIQCNDINPQEDLPVALNNTCGSTRRLLEWMIRWSDKRLLCDSGLTGPSCEYSPVIRVKTSTAAVLTSLWLLEQPYFATYEAKNAIVKVLENNSPGPQNGPSIESDCKTDAGCSVAVSAQGGTEEINDQNESCQSIWKMPTDVKNPEIKGTKDEIISVTDDTEKEFVDIDEALIEVEAFTQEEMDVYPSDHEEDAKLFAKEPVESPNIAIYMQMQTLPQHLDKQHSTGEAQCPREEPRETCMEEESTEQKGMIEASTDLEHIIPHSFCVDTNSEVSSTPVSACKDKSSSAPPLASNGVTVASQTPGPTAQPTQRNEPRAQLSQSSDSVRQMLQDEMFKLVQLQQINFMSLMQIVGSSFANLPDMHQLLQQSQSVHLVGSQASNPTRGSNDVGDTSRNLKERFFIKPQPMAECAREPGKNIPHCHKEIVQSNENSNGNFENVPHGSVPFCQSEGQPQNRGLTPASHSLPTTSLSPVPAGNTHLHLLSTSSAIPKTPRLIPTANTSRPSDGFPLLQFQPKPEFKPISFHTERVPQVPFSPLPQPREAWGLSDFLQPPLPKTAMATTSVSHLNLSQYNTEAIKKAVEPKKWAETIIKEIPKHMNLDQYVGQENLTPQQDSTTFMKPEKIFDVKPGPFEISSQNSSGLPLLHLQLKPPYMFSSASRVSITIPPIPIRTMAEERKCPRLSLLHSCLGPENMYQKPQLIPLENLIAFKQRQQNLTHNSFEQGDPGHLQLLKVKIESSELRQEKDSRKRQRRRAEKELQEERSEKLRRKPSVTFQPENIIINDNDSEVVKPKEQQEHDGSRPLEDFDIPFEKLQDDINTSAGLHFMASVKKKAKECQDASTNTDPEAASQEVVSECHKNQRVISSISEHETLNVPQLLAPDICLNLRLPTEISEKPLSPSASDMVGHTYINVIDIEADDLQELPVKEEPSDNIKPPSDCLEVPSSAELHYMAASVTNAIPPALDNLKSKESAYSAVDLFFKPAKVSPSCLGGSSWRAGSTEVKEPHVISPLPSDVRQDTDTPKPDFHFKEPSSKSDATEDYLLWEVLQEVPTARPVPSPAARRLEHLTAKLQKIDEQLLAIQNLAENIEHNYPPHTAPDRHCMKVEPVGPIELSSGPESEKTFPSKTISISEEEDQRDKEEISVTETYPRQKTCVLPSAHSAVSLPSDQNVTSLGVNNSDELFESASVDPLQMSELTDIADIINDLITKDGVSSEELGLTEQQARSISRMQHPSGRRPQRTEKERREIQVWMKRKRKERMAEYLNQLAEKRGQEHDPFCPRNNPFYMTSREIRLRQKMKHEKDRLLLSDHYSRRISQAYTLMNELLSESVQLPAAAQKPLPNRKAHIPRRQLSPSPRGENRHGHNFPIYRPGKVRHTSTKPSYTQKGRPFGQSQGSPWPRGPNAPCQHCIKSHRSAGLAPQTKEVCIEYEREETVVSPWLVPSDIRAILHESHSSLLQDSSPTEEKSEAPLGVGGTESLSESTGSILSKLDWDAVEDMVAGVEDKSLSVRWALDL", "length": 3232, "header": "tr|F1MRT7-1|F1MRT7_BOVIN Isoform 1 of Ciliosis and planar polarity effector complex subunit 1 OS=Bos taurus OX=9913 GN=CPLANE1 PE=4 SV=5 CANONICAL=F1MRT7-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NBG2-1", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBG2/entry", "sequence": { "sequence": "MEIRLEVLTSTSIKHKKPWPRVSWLGQENEAVFLLDDKSVNEINLLSGRTKKKIPSLQPLLKDVTLLTTSSNDAWLAGVLTTGEVFLWNKDQDCLKTIPATEKPKDMIKAAVASSSRLYLYVSGNGKRVLLMTPSGCIFLWEHLEFKNGLSSKSLSLVGQWSQIMPEEAVPLPSTEDKEAVVHAVFIKNELFGDCCLCSFTFYSGECLKLTFLAIRWHENVFTPVRSLSYHVQWAQQDCLLCSLIPKCESVKSRGALISAFSRDGLTLAVTLNQKDPKATQVLFINTLNFVTLYGSLKGCSNKNPVVPATLVRSYWVGDVSWTHDSLLLACVLKRGSLVLLTCHGELLTLITFGCSIEFGPAEFIPLHPLITYRPQQFTLQDSNNSVDSSASDSDPMRQRFSIKAHSRLPYLIISDGYMVTTLRFLDNLSPSVLMRSLLLDSTQRLEKTYESVILCKDFEAEETDDGRCFPNNLFSFWNQKNDLLFSSVEEGRLEFASMFDTVHAKDNTEETDKTVIELHSVQKNLLAAWTIGISKNVAEKNLMLNYTVVCITHFLYILQFIKCPFPKLDLFLSKSSKHNTWVLCIFQLFHQCLSIQYWDMRYKQDVGHLVKLTSNTIKLLLTQQQQDQLFSEKLLACFHLLRMVADHLNGVYSLQPEVISASADGSRRAKQDSLVLPIFQMFQDSESWENWSWNSSFKIHPQVLNFVQQPGHRLIVLWRILYRKTLWYQMQLSQRVPEDGVQLTEKMTRETSAVKSLLCHIQAELQTAGVRLNQTLELKSINGEECFLLGSYEKSVQIWKKALQETCEKGGRRTCFLQLRYYLSLLYCHLYNYNLNDAQGLCDQLVREILRWSHLPVKENEDCSVPEKSPCESGVTGSVHPEAAVRVVQSMARFMAAYFTNQLLCILPPHSVNVLPPLHIKTEQPFRLIPLQHSKVASAVREQNLSDVWTVEYALELLLIGGLVPEAVWLAHKLGDWKTSVSVGVAFQLFCKHGSKFTRSKEKSLNLPLNMTPAQIFQEKLQCFLGQPASLEAKNEMNSKCKQFTDPIEEEDADLLFASVQEILKAAVMADADILSGTFQLLINSAKDFSKRLWGLVPVGLYLPAPPLYCPQPAVLSEEDGDDLLLKAEKDNRQKVSGILQRILLLFRAARCSFPVAQWYILQLRWARKVMQKIRMKGSLPSLSPFPESLLNYCKGGVAFFRPGAAGDRKLDEASIKAIGCFRELCALCWMLHVRDKLSCSCRQYQKARENVEEKKDLEAKFDPCLVEHCLSAVEWAYRMLPFSRFSNIEELIQDLILSLIAELPPIRKVAEIFVKAFPNPEDIRVSLREKYHSLQQRLRHCVVKGSQTEEMMSVIMHSIHKVRVKALKRVQRNIGSFEMNIWEPVEEEKPAEVAGSDRFSLGTSLSRSTLTELGSSLAHSDADTADTLSEALSAEEKSRTHFCQRSAPNHMELTLTGKPKGKKKIYNQKENPKRKEDCEKLLQNALPVIGVWEFERDDDEYIKFLELFLSYVLERDLLGSKDAGIPFLTSFSGHLRERELNSLLFDVHTTLKRRHSRTKSQNVFRAGSCFVVAPESDECEKSENQSLSASVLANQGIRHFSENPLNEVNKNEGKSGLFGLKQKSVYRIPDDNAEKTLIQRLSNHSVCIPQSTETRRCAFKAIQCNDINPQEDLPVALNNTCGSTRRLLEWMIRWSDKRLLCDSGLTGPSCEYSPVIRVKTSTAAVLTSLWLLEQPYFATYEAKNAIVKVLENNSPGPQNGPSIESDCKTDAGCSVAVSAQGGTEEINDQNESCQSIWKMPTDVKNPEIKGTKDEIISVTDDTEKEFVDIDEALIEVEAFTQEEMDVYPSDHEEDAKLFAKEPVESPNIAIYMQMQTLPQHLDKHSTGEAQCPREEPRETCMEEESTEQKGMIEASTDLEHIIPHSFCVDTNSEVSSTPVSACKDKSSSAPPLASNGVTVASQTPGPTAQPTQRNEPRAQLSQSSDSVRQMLQDEMFKLVQLQQINFMSLMQIVGSSFANLPDMHQLLQQSQSVHLVGSQASNPTRGSNDVGDTSRNLKERFFIKPQPMAECAREPGKNIPHCHKEIVQSNENSNGNFENVPHGSVPFCQSEGQPQNRGLTPASHSLPTTSLSPVPAGNTHLHLLSTSSAIPKTPRLIPTANTSRPSDGFPLLQFQPKPEFKPISFHTERVPQVPFSPLPQPREAWGLSDFLQPPLPKTAMATTSVSHLNLSQYNTEAIKKAVEPKKWAETIIKEIPKHMNLDQYVGQENLTPQQDSTTFMKPEKIFDVKPGPFEISSQNSSGLPLLHLQLKPPYMFSSASRVSITIPPIPIRTMAEERKCPRLSLLHSCLGPENMYQKPQLIPLENLIAFKQRQQNLTHNSFEQGDPGHLQLLKVKIESSELRQEKDSRKRQRRRAEKELQEERSEKLRRKPSVTFQPENIIINDNDSEVVKPKEQQEHDGSRPLEDFDIPFEKLQDDINTSAGLHFMASVKKKAKECQDASTNTDPEAASQEVVSECHKNQRVISSISEHETLNVPQLLAPDICLNLRLPTEISEKPLSPSASDMVGHTYINVIDIEADDLQELPVKEEPSDNIKPPSDCLEVPSSAELHYMAASVTNAIPPALDNLKSKESAYSAVDLFFKPAKVSPSCLGGSSWRAGSTEVKEPHVISPLPSDVRQDTDTPKPDFHFKEPSSKSDATEDYLLWEVLQEVPTARPVPSPAARRLEHLTAKLQKIDEQLLAIQNLAENIEHNYPPHTAPDRHCMKVEPVGPIELSSGPESEKTFPSKTISISEEDQRDKEEISVTETYPRQKTCVLPSAHSAVSLPSDQNVTSLGVNNSDELFESASVDPLQMSELTDIADIINDLITKDGVSSEELGLTEQQARSISRMQHPSGRRPQRTEKERREIQVWMKRKRKERMAEYLNQLAEKRGQEHDPFCPRNNPFYMTSREIRLRQKMKHEKDRLLLSDHYSRRISQAYTLMNELLSESVQLPAAAQKPLPNRKAHIPRRQLSPSPRGENRHGHNFPIYRPGKVRHTSTKPSYTQKGRPFGQSQGSPWPRGPNAPCQHCIKSHRSAGLAPQTKEVCIEYEREETVVSPWLVPSDIRAILHESHSSLLQDSSPTEEKSEAPLGVGGTESLSESTGSILSKLDWDAVEDMVAGVEDKSLSVRWALDL", "length": 3178, "header": "tr|A0A3Q1NBG2-1|F1MRT7_BOVIN Computationally mapped isoform of Ciliosis and planar polarity effector complex subunit 1 OS=Bos taurus OX=9913 GN=CPLANE1 PE=4 SV=3 CANONICAL=F1MRT7-1" }, "locus": { "chromosome": "20", "start_pos": 37150091, "end_pos": 37045115, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000086915.3", "url": "https://www.ensembl.org/id/ENSBTAT00000086915.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000068653.3", "url": "https://www.ensembl.org/id/ENSBTAP00000068653.3" } ] } }, { "isoform_ac": "F1MRT7-1", "url": "https://www.uniprot.org/uniprotkb/F1MRT7/entry", "sequence": { "sequence": "MEIRLEVLTSTSIKHKKPWPRVSWLGQENEAVFLLDDKSVNEINLLSGRTKKKIPSLQPLLKDVTLLTTSSNDAWLAGVLTTGEVFLWNKDQDCLKTIPATEKPKDMIKAAVASSSRLYLYVSGNGKRVLLMTPSGCIFLWEHLEFKNGLSSKSLSLVGQWSQIMPEEAVPLPSTEDKEAVVHAVFIKNELFGDCCLCSFTFYSGECLKLTFLAIRWHENVFTPVRSLSYHVQWAQQDCLLCSLIPKCESVKSRGALISAFSRDGLTLAVTLNQKDPKATQVLFINTLNFVTLYGSLKGCSNKNPVVPATLVRSYWVGDVSWTHDSLLLACVLKRGSLVLLTCHGELLTLITFGCSIEFGPAEFIPLHPLITYRPQQFTLQDSNNSVDSSASDSDPMRQRFSIKAHSRLPYLIISDGYMVTTLRFLDNLSPSVLMRSLLLDSTQRLEKTYESVILCKPKGKGLNLRSLNSLRSSLLKHQRNENVADSTVPKFLQAEETLKLNEETADLQDFEAEETDDGRCFPNNLFSFWNQKNDLLFSSVEEGRLEFASMFDTVHAKDNTEETDKTVIELHSVQKNLLAAWTIGISKNVAEKNLMLNYTVVCITHFLYILQFIKCPFPKLDLFLSKSSKHNTWVLCIFQLFHQCLSIQYWDMRYKQDVGHLVKLTSNTIKLLLTQQQQDQLFSEKLLACFHLLRMVADHLNGVYSLQPEVISASADGSRRAKQDSLVLPIFQMFQDSESWENWSWNSSFKIHPQVLNFVQQPGHRLIVLWRILYRKTLWYQMQLSQRVPEDGVQLTEKMTRETSAVKSLLCHIQAELQTAGVRLNQTLELKSINGEECFLLGSYEKSVQIWKKALQETCEKGGRRTCFLQLRYYLSLLYCHLYNYNLNDAQGLCDQLVREILRWSHLPVKENEDCSVPEKSPCESGVTGSVHPEAAVRVVQSMARFMAAYFTNQLLCILPPHSVNVLPPLHIKTEQPFRLIPLQHSKVASAVREQNLSDVWTVEYALELLLIGGLVPEAVWLAHKLGDWKTSVSVGVAFQLFCKHGSKFTRSKEKSLNLPLNMTPAQIFQEKLQCFLGQPASLEAKNEMNSKCKQFTDPIEEEDADLLFASVQEILKAAVMADADILSGTFQLLINSAKDFSKRLWGLVPVGLYLPAPPLYCPQPAVLSEEDGDDLLLKAEKDNRQKVSGILQRILLLFRAARCSFPVAQWYILQLRWARKVMQKIRMKGSLPSLSPFPESLLNYCKGGVAFFRPGAAGDRKLDEASIKAIGCFRELCALCWMLHVRDKLSCSCRQYQKARENVEEKKDLEAKFDPCLVEHCLSAVEWAYRMLPFSRFSNIEELIQDLILSLIAELPPIRKVAEIFVKAFPNPEDIRVSLREKYHSLQQRLRHCVVKGSQTEEMMSVIMHSIHKVRVKALKRVQRNIGSFEMNIWEPVEEEKPAEVAGSDRFSLGTSLSRSTLTELGSSLAHSDADTADTLSEALSAEEKSRTHFCQRSAPNHMELTLTGKPKGKKKIYNQKENPKRKEDCEKLLQNALPVIGVWEFERDDDEYIKFLELFLSYVLERDLLGSKDAGIPFLTSFSGHLRERELNSLLFDVHTTLKRRHSRTKSQNVFRAGSCFVVAPESDECEKSENQSLSASVLANQGIRHFSENPLNEVNKNEGKSGLFGLKQKSVYRIPDDNAEKTLIQRLSNHSVCIPQSTETRRCAFKAIQCNDINPQEDLPVALNNTCGSTRRLLEWMIRWSDKRLLCDSGLTGPSCEYSPVIRVKTSTAAVLTSLWLLEQPYFATYEAKNAIVKVLENNSPGPQNGPSIESDCKTDAGCSVAVSAQGGTEEINDQNESCQSIWKMPTDVKNPEIKGTKDEIISVTDDTEKEFVDIDEALIEVEAFTQEEMDVYPSDHEEDAKLFAKEPVESPNIAIYMQMQTLPQHLDKQHSTGEAQCPREEPRETCMEEESTEQKGMIEASTDLEHIIPHSFCVDTNSEVSSTPVSACKDKSSSAPPLASNGVTVASQTPGPTAQPTQRNEPRAQLSQSSDSVRQMLQDEMFKLVQLQQINFMSLMQIVGSSFANLPDMHQLLQQSQSVHLVGSQASNPTRGSNDVGDTSRNLKERFFIKPQPMAECAREPGKNIPHCHKEIVQSNENSNGNFENVPHGSVPFCQSEGQPQNRGLTPASHSLPTTSLSPVPAGNTHLHLLSTSSAIPKTPRLIPTANTSRPSDGFPLLQFQPKPEFKPISFHTERVPQVPFSPLPQPREAWGLSDFLQPPLPKTAMATTSVSHLNLSQYNTEAIKKAVEPKKWAETIIKEIPKHMNLDQYVGQENLTPQQDSTTFMKPEKIFDVKPGPFEISSQNSSGLPLLHLQLKPPYMFSSASRVSITIPPIPIRTMAEERKCPRLSLLHSCLGPENMYQKPQLIPLENLIAFKQRQQNLTHNSFEQGDPGHLQLLKVKIESSELRQEKDSRKRQRRRAEKELQEERSEKLRRKPSVTFQPENIIINDNDSEVVKPKEQQEHDGSRPLEDFDIPFEKLQDDINTSAGLHFMASVKKKAKECQDASTNTDPEAASQEVVSECHKNQRVISSISEHETLNVPQLLAPDICLNLRLPTEISEKPLSPSASDMVGHTYINVIDIEADDLQELPVKEEPSDNIKPPSDCLEVPSSAELHYMAASVTNAIPPALDNLKSKESAYSAVDLFFKPAKVSPSCLGGSSWRAGSTEVKEPHVISPLPSDVRQDTDTPKPDFHFKEPSSKSDATEDYLLWEVLQEVPTARPVPSPAARRLEHLTAKLQKIDEQLLAIQNLAENIEHNYPPHTAPDRHCMKVEPVGPIELSSGPESEKTFPSKTISISEEEDQRDKEEISVTETYPRQKTCVLPSAHSAVSLPSDQNVTSLGVNNSDELFESASVDPLQMSELTDIADIINDLITKDGVSSEELGLTEQQARSISRMQHPSGRRPQRTEKERREIQVWMKRKRKERMAEYLNQLAEKRGQEHDPFCPRNNPFYMTSREIRLRQKMKHEKDRLLLSDHYSRRISQAYTLMNELLSESVQLPAAAQKPLPNRKAHIPRRQLSPSPRGENRHGHNFPIYRPGKVRHTSTKPSYTQKGRPFGQSQGSPWPRGPNAPCQHCIKSHRSAGLAPQTKEVCIEYEREETVVSPWLVPSDIRAILHESHSSLLQDSSPTEEKSEAPLGVGGTESLSESTGSILSKLDWDAVEDMVAGVEDKSLSVRWALDL", "length": 3232, "header": "tr|F1MRT7-1|F1MRT7_BOVIN Isoform 1 of Ciliosis and planar polarity effector complex subunit 1 OS=Bos taurus OX=9913 GN=CPLANE1 PE=4 SV=5 CANONICAL=F1MRT7-1" }, "locus": { "chromosome": "20", "start_pos": 37150091, "end_pos": 37045115, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000774.8", "url": "https://www.ensembl.org/id/ENSBTAT00000000774.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000774.8", "url": "https://www.ensembl.org/id/ENSBTAP00000000774.8" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2022, "start_aa": "Thr", "end_pos": 2022, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2022", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 3193, "start_aa": "Thr", "end_pos": 3193, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr3193", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "F1MRT7", "url": "https://www.uniprot.org/uniprotkb/F1MRT7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "ciliary transition zone", "id": "GO:0035869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035869", "evidence": [ { "database": "UniProtKB", "id": "F1MRT7", "url": "https://www.uniprot.org/uniprotkb/F1MRT7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1063, "end_pos": 1065, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1638, "end_pos": 1640, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1697, "end_pos": 1699, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1732, "end_pos": 1734, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1806, "end_pos": 1808, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1844, "end_pos": 1846, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2216, "end_pos": 2218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2284, "end_pos": 2286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2324, "end_pos": 2326, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2354, "end_pos": 2356, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2431, "end_pos": 2433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2501, "end_pos": 2503, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2535, "end_pos": 2537, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2887, "end_pos": 2889, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2894, "end_pos": 2896, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 428, "end_pos": 430, "annotation": "n_glycosylation_sequon" }, { "start_pos": 598, "end_pos": 600, "annotation": "n_glycosylation_sequon" }, { "start_pos": 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"MTHTRRKSLPMLSSGPTGRQEPLQMEGSSVEQRAEGVEPGPPESSEHLTGRRKNYPLRKRPLVPEKPKTCKVLLTRLENVAGPRSADEADELPPDLPKPPSPTPSSEDTALSQPRKRRLASLNAEALNNLLLEREETSSLVGTRRSRGGDPHRSRDRDRATGGWASSKKRPRLGNLGEGSRDLSPEPAPDEGARRDGDPTPKRLASLNAAAFLKLSQERELPLRPPRAHPEADGHSAEPPAPKGLRPKWAKVNSKNYPKARQGAGSSGEAAGPPGWQGCPEEPWPSSPPRGPASQPLYQPLSKALESPLGLRPQLPLLMGGQAALKPEPGRPGEESPAPKQELHQPSFPTPQLSPLPMPGNPADYNGLYGRPELTALGNFYLYCSQDRLQCGGYSSCPMLPEGKLSPVAAPNEGLLLAPSSVPAGTPFQHPPWGSRYCPDEDTGANGYSICEMLSTSLTHIGTTCGGCPYKMPFAAGCRSLGQLEFPLPAAGHPASPAHPLLGCPVPSVPPAAEPVPHLQTPTSEPQTVARACPQSAKPPSGSKSGLRTGSSCRHTARSKAARRPSHPKQPRVQRPRPRRRRRRRTNGWVPVGAACEKAVYVLDEPEPAIRKSYQAVERHGETIRVRDTVLLKSGPRKTSTPYVAKISALWENPESGELMMSLLWYYRPEHLQGGRSPSMHEPLQNEVFASRHQDQNSVACIEEKCYVLTFAEYCRFCAMAKRRGEGLPSRKTALVPPSVDYSTPPHRTVPEDTDPELVFLCRHVYDFRHGRILKNPQ", "length": 778, "header": "tr|F1MSG4-1|F1MSG4_BOVIN Isoform 1 of Bromo adjacent homology domain containing 1 OS=Bos taurus OX=9913 GN=BAHD1 PE=4 SV=4 CANONICAL=F1MSG4-1" }, "isoforms": [ { "isoform_ac": "A0A3Q1NGC0-1", 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{ "chromosome": "10", "start_pos": 36071317, "end_pos": 36065909, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074022.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074022.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000070846.3", "url": "https://www.ensembl.org/id/ENSBTAP00000070846.3" } ] } }, { "isoform_ac": "F1MSG4-1", "url": "https://www.uniprot.org/uniprotkb/F1MSG4/entry", "sequence": { "sequence": "MTHTRRKSLPMLSSGPTGRQEPLQMEGSSVEQRAEGVEPGPPESSEHLTGRRKNYPLRKRPLVPEKPKTCKVLLTRLENVAGPRSADEADELPPDLPKPPSPTPSSEDTALSQPRKRRLASLNAEALNNLLLEREETSSLVGTRRSRGGDPHRSRDRDRATGGWASSKKRPRLGNLGEGSRDLSPEPAPDEGARRDGDPTPKRLASLNAAAFLKLSQERELPLRPPRAHPEADGHSAEPPAPKGLRPKWAKVNSKNYPKARQGAGSSGEAAGPPGWQGCPEEPWPSSPPRGPASQPLYQPLSKALESPLGLRPQLPLLMGGQAALKPEPGRPGEESPAPKQELHQPSFPTPQLSPLPMPGNPADYNGLYGRPELTALGNFYLYCSQDRLQCGGYSSCPMLPEGKLSPVAAPNEGLLLAPSSVPAGTPFQHPPWGSRYCPDEDTGANGYSICEMLSTSLTHIGTTCGGCPYKMPFAAGCRSLGQLEFPLPAAGHPASPAHPLLGCPVPSVPPAAEPVPHLQTPTSEPQTVARACPQSAKPPSGSKSGLRTGSSCRHTARSKAARRPSHPKQPRVQRPRPRRRRRRRTNGWVPVGAACEKAVYVLDEPEPAIRKSYQAVERHGETIRVRDTVLLKSGPRKTSTPYVAKISALWENPESGELMMSLLWYYRPEHLQGGRSPSMHEPLQNEVFASRHQDQNSVACIEEKCYVLTFAEYCRFCAMAKRRGEGLPSRKTALVPPSVDYSTPPHRTVPEDTDPELVFLCRHVYDFRHGRILKNPQ", "length": 778, "header": "tr|F1MSG4-1|F1MSG4_BOVIN Isoform 1 of Bromo adjacent homology domain containing 1 OS=Bos taurus OX=9913 GN=BAHD1 PE=4 SV=4 CANONICAL=F1MSG4-1" }, "locus": { "chromosome": "10", "start_pos": 36072737, "end_pos": 36065909, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005794.7", "url": "https://www.ensembl.org/id/ENSBTAT00000005794.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005794.7", "url": "https://www.ensembl.org/id/ENSBTAP00000005794.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 103, "start_aa": "Thr", "end_pos": 103, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr103", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 350, "start_aa": "Thr", "end_pos": 350, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr350", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "F1MSG4", "url": "https://www.uniprot.org/uniprotkb/F1MSG4" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "F1MSG4", "url": "https://www.uniprot.org/uniprotkb/F1MSG4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "F1MSG4", "url": "https://www.uniprot.org/uniprotkb/F1MSG4" } ], "pmid": "" }, { "name": "heterochromatin formation", "id": "GO:0031507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031507", "evidence": [ { "database": "UniProtKB", "id": "F1MSG4", "url": "https://www.uniprot.org/uniprotkb/F1MSG4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "chromatin silencing complex", "id": "GO:0005677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005677", "evidence": [ { "database": "UniProtKB", "id": "F1MSG4", "url": "https://www.uniprot.org/uniprotkb/F1MSG4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MSG4", "url": "https://www.uniprot.org/uniprotkb/F1MSG4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MSG4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 778, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MSG4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MSG4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MSG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSG4" }, { "id": "PS51038", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51038" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "BAH", "eco_id": "ECO_0000259", "start_pos": 622, "end_pos": 777, "start_aa": "Glu", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 103, 350 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RABEP1", "url": "https://www.uniprot.org/uniprotkb/F1MQH8", "locus": { "chromosome": "19", "start_pos": 26146956, "end_pos": 26246633, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011505", "url": "https://www.ensembl.org/id/ENSBTAG00000011505" } ] } } ], "crossref": [ { "id": "F1MQH8", "url": "https://alphafold.ebi.ac.uk/entry/F1MQH8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011505", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011505", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "504785", "url": "https://www.ncbi.nlm.nih.gov/gene/504785", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "1598187", "url": "https://www.iedb.org/epitope/1598187", "database": "IEDB", "categories": [ "Other" ] }, { "id": "IPR003914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018514", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018514", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504785", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504785", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "XDLKRQN", "url": "https://omabrowser.org/oma/group/XDLKRQN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MQH8", "url": "https://www.orthodb.org/?gene=F1MQH8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31179", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31179", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31179:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31179:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03528", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03528", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09311", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09311", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001180090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180090", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RT16", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RT16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGZ1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUG2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUG2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTQ6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTQ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTQ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQH8-1", "url": "https://www.uniprot.org/uniprotkb/F1MQH8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQPGPAPQPDVSLQQRVAELEKINAEFLRAKQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDEQQRLSKRKDHKKTDVEEEVKIPVVCALTHEESSAQLSNEEEHLDSTHGSVHSLDADLLLPSGDPFSKPDNDVFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVTENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEIHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQVMLRQANDQLEKTMKDKQELEDFIKQSTEDSSHQISALVLRAQASEILLEELQQGFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTMEALRELVLKYRENIVNVRTAADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEMKMTLEEQLKKETAAKVTVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET", "length": 862, "header": "tr|F1MQH8-1|F1MQH8_BOVIN Isoform 1 of Rab GTPase-binding effector protein 1 OS=Bos taurus OX=9913 GN=RABEP1 PE=3 SV=1 CANONICAL=F1MQH8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RT16-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RT16/entry", "sequence": { "sequence": "MAQPGPAPQPDEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDEQQRLSKRKDHKKTDVEEEVKIPVVCALTHEESSAQLSNEEEHLDSTHGSVHSLDADLLLPSGDPFSKPDNDVFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVTENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEIHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQVMLRQANDQLEKTMKDKQELEDFIKQSTEDSSHQISALVLRAQASEILLEELQQGFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTMEALRELVLKYRENIVNVRTAADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEMKMTLEEQLKKETAAKVTVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET", "length": 819, "header": "tr|A0AAA9RT16-1|F1MQH8_BOVIN Computationally mapped isoform of Rab GTPase-binding effector protein 1 OS=Bos taurus OX=9913 GN=RABEP1 PE=3 SV=1 CANONICAL=F1MQH8-1" }, "locus": { "chromosome": "19", "start_pos": 26246368, "end_pos": 26152438, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119149.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119149.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074892.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074892.1" } ] } }, { "isoform_ac": "A0AAA9SGZ1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGZ1/entry", "sequence": { "sequence": "MAQPGPAPQPDVSLQQRVAELEKINAEFLRAKQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDEQQRLSKRKDHKKTDVEEEVKIPVVCALTHEESSAQLSNEEEHLDSTHGSVHSLDADLLLPSGDPFSKPDNDVFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVTENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEIHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQVMLRQANDQLEKTMKDKQELEDFIKQSTEDSSHQISALVLRAQASEILLEELQQGFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTMEALRELVLKYRENIVNVRTAADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEMKMTLEEQLKKETAAKVTVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQLIKGALCFFHHNKKYMKRNT", "length": 849, "header": "tr|A0AAA9SGZ1-1|F1MQH8_BOVIN Computationally mapped isoform of Rab GTPase-binding effector protein 1 OS=Bos taurus OX=9913 GN=RABEP1 PE=3 SV=1 CANONICAL=F1MQH8-1" }, "locus": { "chromosome": "19", "start_pos": 26246368, "end_pos": 26147607, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130935.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130935.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082964.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082964.1" } ] } }, { "isoform_ac": "A0AAA9SUG2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUG2/entry", "sequence": { "sequence": "MKGEKYSFTDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDEQQRLSKRKDHKKTDVEEEVKIPVVCALTHEESSAQLSNEEEHLDSTHGSVHSLDADLLLPSGDPFSKPDNDVFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVTENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEIHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQVMLRQANDQLEKTMKDKQELEDFIKQSTEDSSHQISALVLRAQASEILLEELQQGFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTMEALRELVLKYRENIVNVRTAADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEMKMTLEEQLKKETAAKVTVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET", "length": 816, "header": "tr|A0AAA9SUG2-1|F1MQH8_BOVIN Computationally mapped isoform of Rab GTPase-binding effector protein 1 OS=Bos taurus OX=9913 GN=RABEP1 PE=3 SV=1 CANONICAL=F1MQH8-1" }, "locus": { "chromosome": "19", "start_pos": 26206368, "end_pos": 26152438, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118275.1", "url": "https://www.ensembl.org/id/ENSBTAT00000118275.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087648.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087648.1" } ] } }, { "isoform_ac": "A0AAA9TTQ6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTQ6/entry", "sequence": { "sequence": "MAQPGPAPQPDVSLQQRVAELEKINAEFLRAKQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDEQQRLSKRKDHKKTDVEEEVKIPVVCALTHEESSAQLSNEEEHLDSTHGSVHSLDADLLLPSGDPFSKPDNDVFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVTENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEIHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQVMLRQANDQLEKTMKDKQELEDFIKQSTEDSSHQISALVLRAQASEILLEELQQGFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTMEALRELVLKYRENIVNVRTAADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQVTVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET", "length": 829, "header": "tr|A0AAA9TTQ6-1|F1MQH8_BOVIN Computationally mapped isoform of Rab GTPase-binding effector protein 1 OS=Bos taurus OX=9913 GN=RABEP1 PE=3 SV=1 CANONICAL=F1MQH8-1" }, "locus": { "chromosome": "19", "start_pos": 26246368, "end_pos": 26152438, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135026.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135026.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100749.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100749.1" } ] } }, { "isoform_ac": "F1MQH8-1", "url": "https://www.uniprot.org/uniprotkb/F1MQH8/entry", "sequence": { "sequence": "MAQPGPAPQPDVSLQQRVAELEKINAEFLRAKQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDEQQRLSKRKDHKKTDVEEEVKIPVVCALTHEESSAQLSNEEEHLDSTHGSVHSLDADLLLPSGDPFSKPDNDVFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVTENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEIHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQVMLRQANDQLEKTMKDKQELEDFIKQSTEDSSHQISALVLRAQASEILLEELQQGFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTMEALRELVLKYRENIVNVRTAADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEMKMTLEEQLKKETAAKVTVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET", "length": 862, "header": "tr|F1MQH8-1|F1MQH8_BOVIN Isoform 1 of Rab GTPase-binding effector protein 1 OS=Bos taurus OX=9913 GN=RABEP1 PE=3 SV=1 CANONICAL=F1MQH8-1" }, "locus": { "chromosome": "19", "start_pos": 26246368, "end_pos": 26152438, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015290.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015290.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015290.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015290.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "HLA-DO Modulates the Diversity of the MHC-II Self-peptidome.", "journal": "Molecular & cellular proteomics : MCP", "date": "2019-03", "authors": "Nanaware Padma P, Jurewicz Mollie M, Leszyk John D, Shaffer Scott A, Stern Lawrence J", "evidence": [ { "database": "IEDB", "id": "1598187", "url": "https://www.iedb.org/epitope/1598187" } ], "reference": [ { "type": "PubMed", "id": "30573663", "url": "https://glygen.org/publication/PubMed/30573663" } ] } ], "pathway": [ { "id": "bta:504785", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504785", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AH05-1", "protein_name": "Rab GTPase-binding effector protein 1", "gene_name": "RABEP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRHAEGKNLTSVALLQRVAELEKVNAEFLRTKQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGQLRTQLMEAHAEMENIKAIATVSENTKQEAIDEVKRQWQEEVASLQAIMKETVRDYELQYHHRMEQERAQWNQYRENVEREIAELRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKEKLIEAEEKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDDQQRLSKRKEQKQKDSDDETKASCSLAHEESLTQFSNEEVHLNSTHSSVHSLDADLLLSSGESFNKSENDMFKDGLRRAQSTDSLGTSGSLQSKALGYNNKAKSAGNLDESDFGPLVGADSVSENYDTASLGSLQMPSGFMLTKDQEKAIKAMTPEQEETASLLSSVTQGVESAYVSPSGYRLVSETEWNLLQKEVQNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQVMLRQANDQLEKTMKDKQELEEYMKQSAEDSSNQISLLMVKCQKSENFLNELQQAFSQAKRSVQEQMAVLTQSREQVSEELVRLQKDNESLQGKHSLHVSLQQAEDFILPEAAEELRELILKYREDIISVRTAADHLEEKLKAEILFLKEQIQAEQYLKENIEETLQLEIENCKEEIASISSLKAELERIKVEKEQLESSSQEYLQQLESLQETKNTLEEQLKKETAAKANLEQLVFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET", "length": 860 }, "evidence": [ { "id": "F1MQH8", "url": "https://omabrowser.org/oma/group/F1MQH8/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O35550-1", "protein_name": "Rab GTPase-binding effector protein 1", "gene_name": "Rabep1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAQPGPAPQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERAQWAQYRESADREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDEQQRINKGKDNKKIDTEEEVKIPVVCALTQEESSTPLSNEEEHLDSTHGSVHSLDADLLLPSGDPFSKSDNDMFKEGLRRAQSTDSLGTSSSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTVSLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKEKQELEDFLRQSAEDSSHQISALVLRAQASEVLLEELQQSFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQLAEDFILPDTVQVLRELVLKYRENIVHVRTAADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKVNLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET", "length": 862 }, "evidence": [ { "id": "F1MQH8", "url": "https://omabrowser.org/oma/group/F1MQH8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O35551-1", "protein_name": "Rab GTPase-binding effector protein 1", "gene_name": "Rabep1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAQPGPAPQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAIMKETVRDYEHQFHLRLEQERAQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEEDEQQRVNKRKDNKKTDTEEEVKIPVVCALTQEESSTPLSNEEEHLDSTHGSVHSLDADLMLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSSSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTVSLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKEKQELEDFLKQSAEDSSHQISALVLRAQASEVLLEELQQSFSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQLAEDFILPDTVEVLRELVLKYRENIVHVRTAADHMEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEMKVNLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET", "length": 862 }, "evidence": [ { "id": "F1MQH8", "url": "https://omabrowser.org/oma/group/F1MQH8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q15276-1", "protein_name": "Rab GTPase-binding effector protein 1", "gene_name": "RABEP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET", "length": 862 }, "evidence": [ { "id": "F1MQH8", "url": "https://omabrowser.org/oma/group/F1MQH8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" }, { "name": "growth factor activity", "id": "GO:0008083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008083", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" }, { "name": "endocytic vesicle", "id": "GO:0030139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030139", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" }, { "name": "Golgi to plasma membrane transport", "id": "GO:0006893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006893", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" }, { "name": "protein localization to ciliary membrane", "id": "GO:1903441", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903441", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" }, { "name": "regulation of postsynaptic neurotransmitter receptor internalization", "id": "GO:0099149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099149", "evidence": [ { "database": "UniProtKB", "id": "F1MQH8", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 649, "end_pos": 651, "annotation": "n_glycosylation_sequon" }, { "start_pos": 849, "end_pos": 851, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MQH8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 862, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MQH8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MQH8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MQH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" }, { "id": "PF09311", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09311" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rabaptin GTPase-Rab5 binding", "eco_id": "ECO_0000259", "start_pos": 533, "end_pos": 839, "start_aa": "Cys", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MQH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQH8" }, { "id": "PF03528", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03528" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Rabaptin coiled-coil", "eco_id": "ECO_0000259", "start_pos": 9, "end_pos": 495, "start_aa": "Gln", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 649, "end_pos": 651 }, { "start_pos": 849, "end_pos": 851 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJS8-1", "uniprot_ac": "F1MJS8", "uniprot_id": "F1MJS8_BOVIN", "mass": { "chemical_mass": 94740.0, "monoisotopic_mass": 94740.0 }, "refseq": { "ac": "XP_015326802", "name": "A-kinase anchor protein 3 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015326802" }, "gene_names": [ { "name": "AKAP3", "type": "recommended", "evidence": [ { "id": "F1MJS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS8" } ] }, { "name": "AKAP3", "type": "synonym", "evidence": [ { "id": "XP_015326802", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015326802" } ] } ], "protein_names": [ { "name": "A-kinase anchor protein 3 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_015326802", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015326802" } ] }, { "name": "A-kinase anchoring protein 3", "type": "synonym", "evidence": [ { "id": "F1MJS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS8/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJS8", "url": "https://www.uniprot.org/uniprotkb/F1MJS8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AKAP3", "url": "https://www.uniprot.org/uniprotkb/F1MJS8", "locus": { "chromosome": "5", "start_pos": 105523869, "end_pos": 105495955, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001020", "url": "https://www.ensembl.org/id/ENSBTAG00000001020" } ] } } ], "crossref": [ { "id": "F1MJS8", "url": "https://alphafold.ebi.ac.uk/entry/F1MJS8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001020", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001020", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "281610", "url": "https://www.ncbi.nlm.nih.gov/gene/281610", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008382", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008382", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018292", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018292", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020799", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020799", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MADKVDW", "url": "https://omabrowser.org/oma/group/MADKVDW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MJS8", "url": "https://www.orthodb.org/?gene=F1MJS8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10226:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10226:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05716", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05716", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_015326802", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015326802", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RUE1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUE1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RUE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUE1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJS8", "url": "https://www.uniprot.org/uniprotkb/F1MJS8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJS8-1", "url": "https://www.uniprot.org/uniprotkb/F1MJS8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDRVDWLQSQNGVCKVDVYSPGDSQPQDWKMSDESLSIFKEASHDPIRVLSWLRRDLEKSTAGFQDIRFKPGESSLGREMVSSGDPRKGFCVDYYNTTSRGSPGRLHFEMSHRENPHQGPTCNGSSVDEVSFYANRLTNLVIAMARKEINEKIDGSENRCVHQSVYMGDEPPPNKSLSKVASELVNETVTACSKNTPSDKAPGSGDRASGTLQSPPNLKYKSTLKIKESNKGGRGPDDRPSSKKSFFYKEVFESRNAGDAKEGGRTLPAERKMFRGYERPDDFTASISQGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATIVLKKVLIKHAKEVVSDLIDSFMKNLHNVTGTLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKLYSVIFAKKPPETVRKTKDKSESYSLVSMKGMGDPKHRNVNFASMKSEGKVRERVCTPTPKPEKSCVETLGEHIIKEGLTLWHNSQQKEGISACLQGSPFVTPKRQYKPVPDFPLGFPFDPCNFSLPMQCPEKPENFMCDSDSWAKDLLVSALLLIQYHLAQGGNMDAQSFLEAAGTSNLYPTKSPAVSHESSLRSPQVGADPEEVEKKDLMSVFFNFIRNLLSETIFKSDHSCDPKATKEDNSPQCERPVTPSPAKLNECDETGGAFAGLTKMVANKLDGHMNGQMVDHLMDSVMKLCLIIAKSCDSPLAELGDDKSGDASRPTSAFPESLYECLSTKGTGTAETFLQNAYQAIHNELRSLSAQPPEGCTAPKVIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVEKGRSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMVNL", "length": 858, "header": "tr|F1MJS8-1|F1MJS8_BOVIN Isoform 1 of A-kinase anchoring protein 3 OS=Bos taurus OX=9913 GN=AKAP3 PE=3 SV=1 CANONICAL=F1MJS8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RUE1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RUE1/entry", "sequence": { "sequence": "MSDRVDWLQSQNGVCKVDVYSPGDSQPQDWKMEASHDPIRVLSWLRRDLEKSTAGFQDIRFKPGESSLGREMVSSGDPRKGFCVDYYNTTSRGSPGRLHFEMSHRENPHQGPTCNGSSVDEVSFYANRLTNLVIAMARKEINEKIDGSENRCVHQSVYMGDEPPPNKSLSKVASELVNETVTACSKNTPSDKAPGSGDRASGTLQSPPNLKYKSTLKIKESNKGGRGPDDRPSSKKSFFYKEVFESRNAGDAKEGGRTLPAERKMFRGYERPDDFTASISQGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATIVLKKVLIKHAKEVVSDLIDSFMKNLHNVTGTLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKLYSVIFAKKPPETVRKTKDKSESYSLVSMKGMGDPKHRNVNFASMKSEGKVRERVCTPTPKPEKSCVETLGEHIIKEGLTLWHNSQQKEGISACLQGSPFVTPKRQYKPVPDFPLGFPFDPCNFSLPMQCPEKPENFMCDSDSWAKDLLVSALLLIQYHLAQGGNMDAQSFLEAAGTSNLYPTKSPAVSHESSLRSPQVGADPEEVEKKDLMSVFFNFIRNLLSETIFKSDHSCDPKATKEDNSPQCERPVTPSPAKLNECDETGGAFAGLTKMVANKLDGHMNGQMVDHLMDSVMKLCLIIAKSCDSPLAELGDDKSGDASRPTSAFPESLYECLSTKGTGTAETFLQNAYQAIHNELRSLSAQPPEGCTAPKVIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEK", "length": 798, "header": "tr|A0AAA9RUE1-1|F1MJS8_BOVIN Computationally mapped isoform of A-kinase anchoring protein 3 OS=Bos taurus OX=9913 GN=AKAP3 PE=3 SV=1 CANONICAL=F1MJS8-1" }, "locus": { "chromosome": "5", "start_pos": 105515756, "end_pos": 105508468, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133573.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133573.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076792.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076792.1" } ] } }, { "isoform_ac": "F1MJS8-1", "url": "https://www.uniprot.org/uniprotkb/F1MJS8/entry", "sequence": { "sequence": "MSDRVDWLQSQNGVCKVDVYSPGDSQPQDWKMSDESLSIFKEASHDPIRVLSWLRRDLEKSTAGFQDIRFKPGESSLGREMVSSGDPRKGFCVDYYNTTSRGSPGRLHFEMSHRENPHQGPTCNGSSVDEVSFYANRLTNLVIAMARKEINEKIDGSENRCVHQSVYMGDEPPPNKSLSKVASELVNETVTACSKNTPSDKAPGSGDRASGTLQSPPNLKYKSTLKIKESNKGGRGPDDRPSSKKSFFYKEVFESRNAGDAKEGGRTLPAERKMFRGYERPDDFTASISQGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATIVLKKVLIKHAKEVVSDLIDSFMKNLHNVTGTLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKLYSVIFAKKPPETVRKTKDKSESYSLVSMKGMGDPKHRNVNFASMKSEGKVRERVCTPTPKPEKSCVETLGEHIIKEGLTLWHNSQQKEGISACLQGSPFVTPKRQYKPVPDFPLGFPFDPCNFSLPMQCPEKPENFMCDSDSWAKDLLVSALLLIQYHLAQGGNMDAQSFLEAAGTSNLYPTKSPAVSHESSLRSPQVGADPEEVEKKDLMSVFFNFIRNLLSETIFKSDHSCDPKATKEDNSPQCERPVTPSPAKLNECDETGGAFAGLTKMVANKLDGHMNGQMVDHLMDSVMKLCLIIAKSCDSPLAELGDDKSGDASRPTSAFPESLYECLSTKGTGTAETFLQNAYQAIHNELRSLSAQPPEGCTAPKVIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVEKGRSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMVNL", "length": 858, "header": "tr|F1MJS8-1|F1MJS8_BOVIN Isoform 1 of A-kinase anchoring protein 3 OS=Bos taurus OX=9913 GN=AKAP3 PE=3 SV=1 CANONICAL=F1MJS8-1" }, "locus": { "chromosome": "5", "start_pos": 105523644, "end_pos": 105508468, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001353.6", "url": "https://www.ensembl.org/id/ENSBTAT00000001353.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001353.3", "url": "https://www.ensembl.org/id/ENSBTAP00000001353.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7GH76-1", "protein_name": "A-kinase anchor protein 3 isoform X1", "gene_name": "Akap3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MACEGRLTPLGSLQFRLSRGPTPGRAKVPGSSAGLGLGSGGAVALRSRSCRQEKRKKQSEGLRRVHKWGREIGTRRRPPPRSPARSLAAEVRARGCRQEHPFFGALVLTAPVHAQNACLGVYTNSNLLARDSPGTSDLSKMADRVDWLQSQSGVCKVDVYSPGDNQHQDWKMDASTDPVRVLSWLRRDLEKSTAGFQDSRFKPGESSFGEEVANPGDQRKGFCVDYYNTTNRNNPGRLHFEMTHKENPSPGPITQTGNGSSIDEVSFYANRLTNLVIAMARKEINEKIHGSDNKCIHQSFYMGDEPTPHKSLSTVASELVNETVSSCSKNIAGDKAPGSGDRAAGSTQSPSLRYKSTLKIKESTKDGKCPDDKPGSKKSFFYKEVFESRNAGDAKDGGRSLPGDRKLFRSPDRPDDYTNTVSQGIMTYANSVVSDMMVSIMKTLRIQVKDTTIATILLKKVLIKHAKEVVSDLIDSFMKNLHNVTGSLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKLYNVMFAKKFPENIRKARDKSESYSLISMKSRAGDPRQPNMNFAMKSESKMRESLFSACKSEKDKTCAETLGEHIIKEGLTMWHKTHQKDCKSPSLDSAVKQGSPQPEVSFESPDSCDLTPPPQQPEVIENFMCEQDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLEAAASTNFPHAKAPVVHDESRLKSPHKICDQEQTEKKDLMSVIFNFIRNLLSETIFKSKRNCESKGQNVREEEISPCERPITPPAPKFCEEEEEEASGAFCGLSKMVANQLDGSMNGQMVEHLMDSVMKLCLIIAKSCDSPLSELGDEKCGDASRPNSAFPDNLYECLPVKGTGTAEALLQNAYQAIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVEKGRSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMANL", "length": 990 }, "evidence": [ { "id": "F1MJS8", "url": "https://omabrowser.org/oma/group/F1MJS8/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O75969-1", "protein_name": "A-kinase anchor protein 3", "gene_name": "AKAP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEKVDWLQSQNGVCKVDVYSPGDNQAQDWKMDTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPGESFGGETSNSGDPHKGFSVDYYNTTTKGTPERLHFEMTHKEIPCQGPRAQLGNGSSVDEVSFYANRLTNLVIAMARKEINEKIDGSENKCVYQSLYMGNEPTPTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRVSGSSQSPPNLKYKSTLKIKESTKERQGPDDKPPSKKSFFYKEVFESRNGDYAREGGRFFPRERKRFRGQERPDDFTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATILLKKVLLKHAKEVVSDLIDSFLRNLHSVTGTLMTDTQFVSAVKRTVFSHGSQKATDIMDAMLRKLYNVMFAKKVPEHVRKAQDKAESYSLISMKGMGDPKNRNVNFAMKSETKLREKMYSEPKSEEETCAKTLGEHIIKEGLTLWHKTQQKECKSLGFQHAAFEAPNTQRKPASDISFEYPEDIGNLSLPPYPPEKPENFMYDSDSWAEDLIVSALLLIQYHLAQGGRRDARSFVEAAGTTNFPANEPPVAPDESCLKSAPIVGDQEQAEKKDLRSVFFNFIRNLLSETIFKRDQSPEPKVPEQPVKEDRKLCERPLASSPPRLYEDDETPGALSGLTKMAVSQIDGHMSGQMVEHLMNSVMKLCVIIAKSCDASLAELGDDKSGDASRLTSAFPDSLYECLPAKGTGSAEAVLQNAYQAIHNEMRGTSGQPPEGCAAPTVIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVDKGCSVGEVLQSVLRYEKERQLNEAVGNVTPLQLLDWLMVNL", "length": 853 }, "evidence": [ { "id": "F1MJS8", "url": "https://omabrowser.org/oma/group/F1MJS8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O88987-1", "protein_name": "A-kinase anchor protein 3", "gene_name": "Akap3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADRVDWLQSQSGVCKVGVYSPGDNQHQDWKMDTSTDPVRVLSWLRKDLEKSTAGFQDSRFKPGESSFVEEVAYPVDQRKGFCVDYYNTTNKGSPGRLHFEMSHKENPSQGLISHVGNGGSIDEVSFYANRLTNLVIAMARKEINEKIHGAENKCVHQSLYMGDEPTPHKSLSTVASELVNETVTACSKNISSDKAPGSGDRASGSSQAPGLRYTSTLKIKESTKEGKCPDDKPGTKKSFFYKEVFESRNAGDAKEGGRSLPGDQKLFRTSPDNRPDDFSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATILLKKVLMKHAKEVVSDLIDSFMKNLHGVTGSLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKLYNVMFAKKFPENIRRARDKSESYSLISTKSRAGDPKLSNLNFAMKSESKLKENLFSTCKLEKEKTCAETLGEHIIKEGLHMWHKSQQKSPGLERAAKLGNAPQEVSFECPDPCEANPPHQPQPPENFANFMCDSDSWAKDLIVSALLLIQYHLAQGGKMDAQSFLEAAASTNFPTNKPPPPSPVVQDECKLKSPPHKICDQEQTEKKDLMSVIFNFIRNLLSETIFKSSRNCESNVHEQNTQEEEIHPCERPKTPCERPITPPAPKFCEDEEATGGALSGLTKMVANQLDNCMNGQMVEHLMDSVMKLCLIIAKSCDSPLSELGEEKCGDASRPNSAFPDNLYECLPVKGTGTAEALLQNAYLTIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSATAVEKGRSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMANL", "length": 864 }, "evidence": [ { "id": "F1MJS8", "url": "https://omabrowser.org/oma/group/F1MJS8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q66HC6-1", "protein_name": "A-kinase anchoring protein 3", "gene_name": "Akap3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQRRPHLKPLAAKMADRVDWLQSQSGVCKVGVYSPGDNQHQDWKMDSSTDPVRVLSWLRKDLEKSTAGFQDSRFKPGESSFGEEVAYPGDQRKGFCVDYYNTTNKGNPGRLHFEMSHKETPPQGLIAHVGNGGSIDEVSFYANRLTNLVIAMARKEINEKIHGTENKCVHQSLYMGDDPTPHKSLSTVASELVNETVSACSKNITGDKAPGSGDRALASSQSPGLRFTSTLKIKESTKEGKCPDNKPGSKKSFFYKEVFESRNAGDAKEGGRSLPGDRKLFRCPDRPDDFSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATILLKKVLMKHAKEVVSDLIDSFMKNLHSVTGSLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKLYNVMCAKKYPENIRKARDKSESYSLISMKSRPGDPKLSNLNFAMKSESKLKENLFSACISEKEKTCAETLGEHIIKEGLNMWHKSQQNSPGLERATKQGAVPQEVSFECPDPCEVNPLQQPQPPENFENFMCESDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLEAAASTNFPTKSSPVVHDEGKVKSPPLKICEQEQTEKKDLMSVIFNFIRNLLSETIFKGSRNCESKAHEQIIKEEEINLCERPLSPCERPMSPPVPKFCEDEEATGGALSGLTKMVANQLDGCMNGQMVEHLMDSVMKLCLIIAKSCDSPLSELGDEKCGDASRPSSAFPDNLYECLPVKGTGTAEALLQNAYLAIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSATAVEKGRSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMANL", "length": 871 }, "evidence": [ { "id": "F1MJS8", "url": "https://omabrowser.org/oma/group/F1MJS8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "F1MJS8", "url": "https://www.uniprot.org/uniprotkb/F1MJS8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MJS8", "url": "https://www.uniprot.org/uniprotkb/F1MJS8" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "F1MJS8", "url": "https://www.uniprot.org/uniprotkb/F1MJS8" } ], "pmid": "" }, { "name": "sperm fibrous sheath", "id": "GO:0035686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035686", "evidence": [ { "database": "UniProtKB", "id": "F1MJS8", "url": "https://www.uniprot.org/uniprotkb/F1MJS8" } ], "pmid": "" }, { "name": "sperm principal piece", "id": "GO:0097228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097228", "evidence": [ { "database": "UniProtKB", "id": "F1MJS8", "url": "https://www.uniprot.org/uniprotkb/F1MJS8" } ], "pmid": "" }, { "name": "sperm midpiece", "id": "GO:0097225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097225", "evidence": [ { "database": "UniProtKB", "id": "F1MJS8", "url": "https://www.uniprot.org/uniprotkb/F1MJS8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "F1MJS8", "url": "https://www.uniprot.org/uniprotkb/F1MJS8" } ], "pmid": "" }, { "name": "establishment of protein localization", "id": "GO:0045184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045184", "evidence": [ { "database": "UniProtKB", "id": "F1MJS8", "url": "https://www.uniprot.org/uniprotkb/F1MJS8" } ], "pmid": "" }, { "name": "cell surface receptor protein serine/threonine kinase signaling pathway", "id": "GO:0007178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007178", "evidence": [ { "database": "UniProtKB", "id": "F1MJS8", "url": "https://www.uniprot.org/uniprotkb/F1MJS8" } ], "pmid": "" }, { "name": "intracellular protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "F1MJS8", "url": "https://www.uniprot.org/uniprotkb/F1MJS8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein kinase A binding", "id": "GO:0051018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051018", "evidence": [ { "database": "UniProtKB", "id": "F1MJS8", "url": "https://www.uniprot.org/uniprotkb/F1MJS8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 350, "end_pos": 352, "annotation": "n_glycosylation_sequon" }, { "start_pos": 510, "end_pos": 512, "annotation": "n_glycosylation_sequon" }, { "start_pos": 768, "end_pos": 770, "annotation": "n_glycosylation_sequon" }, { "start_pos": 844, "end_pos": 846, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJS8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 858, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJS8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJS8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS8" }, { "id": "PF05716", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05716" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "A-kinase anchor 110kDa C-terminal", "eco_id": "ECO_0000259", "start_pos": 174, "end_pos": 858, "start_aa": "Pro", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 124, "end_pos": 126 }, { "start_pos": 175, "end_pos": 177 }, { "start_pos": 187, "end_pos": 189 }, { "start_pos": 350, "end_pos": 352 }, { "start_pos": 510, "end_pos": 512 }, { "start_pos": 768, "end_pos": 770 }, { "start_pos": 844, "end_pos": 846 }, { "start_pos": 97, "end_pos": 99 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { 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"https://www.ensembl.org/id/ENSBTAG00000001639" } ] } } ], "crossref": [ { "id": "F1MPU3", "url": "https://alphafold.ebi.ac.uk/entry/F1MPU3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000001639", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000001639", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041491", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041491", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050927", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050927", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057366", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057366", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MPU3", "url": "https://www.orthodb.org/?gene=F1MPU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13800", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13800", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13800:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13800:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16519", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16519", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18139", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18139", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25508", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25508", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "28699", "url": "https://www.rhea-db.org/rhea/28699", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "29671", "url": "https://www.rhea-db.org/rhea/29671", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "29827", "url": "https://www.rhea-db.org/rhea/29827", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RXT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPU3", "url": "https://www.uniprot.org/uniprotkb/F1MPU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPU3-1", "url": "https://www.uniprot.org/uniprotkb/F1MPU3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSSFKRGSLKSSTSGSQKGQKAWIEKTFCKRECIFVIPSTKDPNRCCCGQLTNQHIPPLPSVTASKNGEENKLVEVHPEKWSVGKHTQSYPTDSYGILEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVRDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGRDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVMLRRQLEKHISLQKINTRLGQGVPLVGLVVEGGPNVVSIVLEYLREEPPVPVVVCDGSGRASDILSFAHKYSEEGGIINDSLRDQLIVTIQKTFNYNKTQSHQLFAMIMECMKKKELVTVFRMGSEGQQDIEMAILTALLKGTNASAPDQLSLALAWNRVDIARSQIFVFGPRWPPLGSLAPPTDSKATEKEKKPPAATTKGGRGKGKGKKKGKVKEEVEEETDPRKLELLNWVNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKGNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKSFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEELDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKSMAHESSESELVDDISQDLDNNSKDFGQLAVELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLDFRTYDDFYQTSKENEDGKEKEEENMDANADASSRKGDEENEHKKQRSVPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMERWPCLQEWIVISYILSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISMFMIGAILRLQKQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPDEEPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGDNQYDEEGKRLPPCIPGAWLTPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSRRCRKKREGDQDEQDRGLKLFLSDEELKRLHEFEEQCVREHFQEKEDEQQSSSEERIRVTCERVENMSMRLEEINERENFMKTSLQTVDLRLSQLEELSNRMVNALENLAGIDKSDLIQTRSRASSECDATFLLRRSSISSADGYSLYRYHFNGDELLYEDTSFCMPPGAASRKKAGSFRGKEEKDQRTYLAPERQGSLRLPPSTGAPASPDRGQLASDNCKSSSEPKSGPDTGISAENDERQVDTKKEEMTSPNLSQTDAIHGEDKSDFQKSTQLTVETTKVESTISYPLEETKTSHYYPDETFSACETLKSRSFVYSRGRKVVGGANLGYSPTCPSTVQQWTTEWKYEVQKIMRSRSTEIPSFASEAALQAEHCGHFTDKEDENCVFKTAPQISRLSVTDRTDKENLLSVKTHQTLGFPSSRSKSLHGRPRSVKALQGNLHRPGHASSVSNLVVVSGITMEDPKVQQEKTSSETEC", "length": 1642, "header": "tr|F1MPU3-1|F1MPU3_BOVIN Isoform 1 of Transient receptor potential cation channel subfamily M member 1 OS=Bos taurus OX=9913 GN=TRPM1 PE=4 SV=4 CANONICAL=F1MPU3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXT3/entry", "sequence": { "sequence": "MYIRVSYDTKPDSLLHLMVRDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGRDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVMLRRQLEKHISLQKINTRLGQGVPLVGLVVEGGPNVVSIVLEYLREEPPVPVVVCDGSGRASDILSFAHKYSEEGGIINDSLRDQLIVTIQKTFNYNKTQSHQLFAMIMECMKKKELVTVFRMGSEGQQDIEMAILTALLKGTNASAPDQLSLALAWNRVDIARSQIFVFGPRWPPLGSLAPPTDSKATEKEKKPPAATTKGGRGKGKGKKKGKVKEEVEEETDPRKLELLNWVNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKDDEPPAKGKKKKKKKKEEELDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKSMAHESSESELVDDISQDLDNNSKDFGQLAVELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLDFRTYDDFYQTSKENEDGKEKEEENMDANADASSRKGDEENEHKKQRSVPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMERWPCLQEWIVISYILSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISMFMIGAILRLQKQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPDEEPSWKLARNIFYMPYWMIYGEVFADQIDRKNRIHTPCGDNQYDEEGKRLPPCIPGAWLTPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSRRCRKKREGDQDEQDRGLKLFLSDEELKRLHEFEEQCVREHFQEKEDEQQSSSEERIRVTCERVENMSMRLEEINERENFMKTSLQTVDLRLSQLEELSNRMVNALENLAGIDKSDLIQTRSRASSECDATFLLRRSSISSADGYSLYRYHFNGDELLYEDTSFCMPPGAASRKKAGSFRGKEEKDQRTYLAPERQGSLRLPPSTGAPASPDRGQLASDNCKSSSEPKSGPDTGISAENDERQVDTKKEEMTSPNLSQTDAIHGEDKSDFQKSTQLTVETTKVESTISYPLEETKTSHYYPDETFSACETLKSRSFVYSRGRKVVGGANNWGTAGDPTCPSTVQQWTTEWKYEVQKIMRSRSTEIPSFASEAALQAEHCGHFTDKEDENCVFKTAPQISRLSVTDRTDKENLLSVKTHQTLGFPSSRSKSLHGRPRSVKALQGNLHRPGHASSVSNLVVVSGITMEDPKVQQEKTSSETEC", "length": 1477, "header": "tr|A0AAA9RXT3-1|F1MPU3_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily M member 1 OS=Bos taurus OX=9913 GN=TRPM1 PE=4 SV=1 CANONICAL=F1MPU3-1" }, "locus": { "chromosome": "21", "start_pos": 27543159, "end_pos": 27483837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117274.1", "url": "https://www.ensembl.org/id/ENSBTAT00000117274.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000074627.1", "url": "https://www.ensembl.org/id/ENSBTAP00000074627.1" } ] } }, { "isoform_ac": "F1MPU3-1", "url": "https://www.uniprot.org/uniprotkb/F1MPU3/entry", "sequence": { "sequence": "MSSSFKRGSLKSSTSGSQKGQKAWIEKTFCKRECIFVIPSTKDPNRCCCGQLTNQHIPPLPSVTASKNGEENKLVEVHPEKWSVGKHTQSYPTDSYGILEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVRDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGRDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVMLRRQLEKHISLQKINTRLGQGVPLVGLVVEGGPNVVSIVLEYLREEPPVPVVVCDGSGRASDILSFAHKYSEEGGIINDSLRDQLIVTIQKTFNYNKTQSHQLFAMIMECMKKKELVTVFRMGSEGQQDIEMAILTALLKGTNASAPDQLSLALAWNRVDIARSQIFVFGPRWPPLGSLAPPTDSKATEKEKKPPAATTKGGRGKGKGKKKGKVKEEVEEETDPRKLELLNWVNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKGNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKSFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEELDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKSMAHESSESELVDDISQDLDNNSKDFGQLAVELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLDFRTYDDFYQTSKENEDGKEKEEENMDANADASSRKGDEENEHKKQRSVPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMERWPCLQEWIVISYILSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISMFMIGAILRLQKQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPDEEPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGDNQYDEEGKRLPPCIPGAWLTPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSRRCRKKREGDQDEQDRGLKLFLSDEELKRLHEFEEQCVREHFQEKEDEQQSSSEERIRVTCERVENMSMRLEEINERENFMKTSLQTVDLRLSQLEELSNRMVNALENLAGIDKSDLIQTRSRASSECDATFLLRRSSISSADGYSLYRYHFNGDELLYEDTSFCMPPGAASRKKAGSFRGKEEKDQRTYLAPERQGSLRLPPSTGAPASPDRGQLASDNCKSSSEPKSGPDTGISAENDERQVDTKKEEMTSPNLSQTDAIHGEDKSDFQKSTQLTVETTKVESTISYPLEETKTSHYYPDETFSACETLKSRSFVYSRGRKVVGGANLGYSPTCPSTVQQWTTEWKYEVQKIMRSRSTEIPSFASEAALQAEHCGHFTDKEDENCVFKTAPQISRLSVTDRTDKENLLSVKTHQTLGFPSSRSKSLHGRPRSVKALQGNLHRPGHASSVSNLVVVSGITMEDPKVQQEKTSSETEC", "length": 1642, "header": "tr|F1MPU3-1|F1MPU3_BOVIN Isoform 1 of Transient receptor potential cation channel subfamily M member 1 OS=Bos taurus OX=9913 GN=TRPM1 PE=4 SV=4 CANONICAL=F1MPU3-1" }, "locus": { "chromosome": "21", "start_pos": 27583101, "end_pos": 27483837, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010233.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010233.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010233.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010233.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MPU3", "url": "https://www.uniprot.org/uniprotkb/F1MPU3" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1MPU3", "url": "https://www.uniprot.org/uniprotkb/F1MPU3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "protein tetramerization", "id": "GO:0051262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051262", "evidence": [ { "database": "UniProtKB", "id": "F1MPU3", "url": "https://www.uniprot.org/uniprotkb/F1MPU3" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "F1MPU3", "url": "https://www.uniprot.org/uniprotkb/F1MPU3" } ], "pmid": "" }, { "name": "calcium ion import across plasma membrane", "id": "GO:0098703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098703", "evidence": [ { "database": "UniProtKB", "id": "F1MPU3", "url": "https://www.uniprot.org/uniprotkb/F1MPU3" } ], "pmid": "" }, { "name": "G protein-coupled glutamate receptor signaling pathway", "id": "GO:0007216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007216", "evidence": [ { "database": "UniProtKB", "id": "F1MPU3", "url": "https://www.uniprot.org/uniprotkb/F1MPU3" } ], "pmid": "" }, { "name": "cellular response to light stimulus", "id": "GO:0071482", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071482", "evidence": [ { "database": "UniProtKB", "id": "F1MPU3", "url": "https://www.uniprot.org/uniprotkb/F1MPU3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "monoatomic cation channel activity", "id": "GO:0005261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005261", "evidence": [ { "database": "UniProtKB", "id": "F1MPU3", "url": "https://www.uniprot.org/uniprotkb/F1MPU3" } ], "pmid": "" }, { "name": "calcium channel activity", "id": "GO:0005262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "evidence": [ { "database": "UniProtKB", "id": "F1MPU3", "url": "https://www.uniprot.org/uniprotkb/F1MPU3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1115, "end_pos": 1117, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1230, "end_pos": 1232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1419, "end_pos": 1421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 254, "end_pos": 256, "annotation": "n_glycosylation_sequon" }, { "start_pos": 343, "end_pos": 345, "annotation": "n_glycosylation_sequon" }, { "start_pos": 361, "end_pos": 363, "annotation": "n_glycosylation_sequon" }, { "start_pos": 408, "end_pos": 410, "annotation": "n_glycosylation_sequon" }, { "start_pos": 588, "end_pos": 590, "annotation": "n_glycosylation_sequon" }, { "start_pos": 711, "end_pos": 713, "annotation": "n_glycosylation_sequon" }, { "start_pos": 745, "end_pos": 747, "annotation": "n_glycosylation_sequon" }, { "start_pos": 748, "end_pos": 750, "annotation": "n_glycosylation_sequon" }, { "start_pos": 939, "end_pos": 941, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "28699", "name": "", "equation": "Mn(2+)(in) = Mn(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "28699", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/28699" } ] }, { "id": "29671", "name": "", "equation": "Ca(2+)(in) = Ca(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29671" } ] }, { "id": "29827", "name": "", "equation": "Mg(2+)(in) = Mg(2+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MPF0-1", "A0AAA9RSQ6-1" ], "evidence": [ { "id": "29827", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29827" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MPU3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1642, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MPU3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MPU3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MPU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPU3" }, { "id": "PF00520", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ion transport", "eco_id": "ECO_0000259", "start_pos": 876, "end_pos": 1123, "start_aa": "Ser", "end_aa": "Ser", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MPU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPU3" }, { "id": "PF18139", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18139" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TRPM SLOG", "eco_id": "ECO_0000259", "start_pos": 110, "end_pos": 375, "start_aa": "Ala", "end_aa": "Cys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MPU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPU3" }, { "id": "PF16519", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16519" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "TRPM tetramerisation", "eco_id": "ECO_0000259", "start_pos": 1218, "end_pos": 1273, "start_aa": "Glu", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MPU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPU3" }, { "id": "PF25508", 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"sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MS25-1", "uniprot_ac": "F1MS25", "uniprot_id": "F1MS25_BOVIN", "mass": { "chemical_mass": 51219.0, "monoisotopic_mass": 51219.0 }, "refseq": {}, "gene_names": [ { "name": "NDUFS3", "type": "recommended", "evidence": [ { "id": "F1MS25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS25" } ] } ], "protein_names": [ { "name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial", "type": "recommended", "evidence": [ { "id": "F1MS25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS25/entry#names_and_taxonomy" } ] }, { "name": "Complex I-30kD", "type": "synonym", "evidence": [ { "id": "F1MS25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS25/entry#names_and_taxonomy" } ] }, { "name": "NADH-ubiquinone oxidoreductase 30 kDa subunit", "type": "synonym", "evidence": [ { "id": "F1MS25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS25/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.", "evidence": [ { "database": "UniProtKB", "id": "F1MS25", "url": "https://www.uniprot.org/uniprotkb/F1MS25#function" }, { "database": "UniProtKB", "id": "ARBA00024313", "url": "https://www.uniprot.org/uniprotkb/ARBA00024313#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MS25", "url": "https://www.uniprot.org/uniprotkb/F1MS25" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NDUFS3", "url": "https://www.uniprot.org/uniprotkb/F1MS25", "locus": { "chromosome": "15", "start_pos": 77383888, "end_pos": 77379153, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018483", "url": "https://www.ensembl.org/id/ENSBTAG00000018483" } ] } } ], "crossref": [ { "id": "F1MS25", "url": "https://alphafold.ebi.ac.uk/entry/F1MS25", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018483", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018483", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001268", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001268", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010218", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010218", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029021", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037232", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037232", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "PCRKNRF", "url": "https://omabrowser.org/oma/group/PCRKNRF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MS25", "url": "https://www.orthodb.org/?gene=F1MS25", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10884", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10884", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10884:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10884:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00329", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00329", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-611105", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9013408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9837999", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9837999", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "29091", "url": "https://www.rhea-db.org/rhea/29091", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RXV0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXV0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RXV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXV0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS25", "url": "https://www.uniprot.org/uniprotkb/F1MS25", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS25-1", "url": "https://www.uniprot.org/uniprotkb/F1MS25-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVWVPGAPGGPGDSPGAGPEVATLERPAPAGSSSLGAAAASPPPWPGPRSPASCPAVGGSPLRRAGWAGMAAGTLLEAGLARVLYYPTLLYTVFRGKMPGRAHRDWYHRIDSTVLLGALPLRSMTRRLVQDENVRGVITMNEEYETRFLCNSSKVYHWTPEEAIRAITKIRSHIYIRPGQLEVLKEFHKPGTWNLCFWPRVRPEERLMHTSASVAGRPSVLLLPVRRESSAADTRPTVRPRNAVAHKQLSAFGEYVAEILPKYVQQVQVSCFNELEICIHPDGVIPVLTFLRDHSNAQFKSLADLTAVDIPTRQNRFEIVYNLLSLRFNSRIRVKTYTDELTPIESSVPVYKAANWYEREIWDMFGVFFANHPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPAYRQPPESLKLEAGDTKPEAK", "length": 455, "header": "tr|F1MS25-1|F1MS25_BOVIN Isoform 1 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Bos taurus OX=9913 GN=NDUFS3 PE=3 SV=4 CANONICAL=F1MS25-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RXV0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RXV0/entry", "sequence": { "sequence": "MAAAVAAAARGCWQRLVGSAAPARVAGRPSVLLLPVRRESSAADTRPTVRPRNAVAHKQLSAFGEYVAEILPKYVQQVQVIFTTGVWIWIKKEPCSQGMWEWAAWNQKYRLLHPLGLLSLP", "length": 121, "header": "tr|A0AAA9RXV0-1|F1MS25_BOVIN Computationally mapped isoform of NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Bos taurus OX=9913 GN=NDUFS3 PE=3 SV=1 CANONICAL=F1MS25-1" }, "locus": { "chromosome": "15", "start_pos": 77380752, "end_pos": 77379157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135741.2", "url": "https://www.ensembl.org/id/ENSBTAT00000135741.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075968.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075968.1" } ] } }, { "isoform_ac": "F1MS25-1", "url": "https://www.uniprot.org/uniprotkb/F1MS25/entry", "sequence": { "sequence": "MVWVPGAPGGPGDSPGAGPEVATLERPAPAGSSSLGAAAASPPPWPGPRSPASCPAVGGSPLRRAGWAGMAAGTLLEAGLARVLYYPTLLYTVFRGKMPGRAHRDWYHRIDSTVLLGALPLRSMTRRLVQDENVRGVITMNEEYETRFLCNSSKVYHWTPEEAIRAITKIRSHIYIRPGQLEVLKEFHKPGTWNLCFWPRVRPEERLMHTSASVAGRPSVLLLPVRRESSAADTRPTVRPRNAVAHKQLSAFGEYVAEILPKYVQQVQVSCFNELEICIHPDGVIPVLTFLRDHSNAQFKSLADLTAVDIPTRQNRFEIVYNLLSLRFNSRIRVKTYTDELTPIESSVPVYKAANWYEREIWDMFGVFFANHPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPAYRQPPESLKLEAGDTKPEAK", "length": 455, "header": "tr|F1MS25-1|F1MS25_BOVIN Isoform 1 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Bos taurus OX=9913 GN=NDUFS3 PE=3 SV=4 CANONICAL=F1MS25-1" }, "locus": { "chromosome": "15", "start_pos": 77383805, "end_pos": 77368224, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024600.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024600.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024600.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024600.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-611105", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "resource": "Reactome", "description": "Respiratory electron transport" }, { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" }, { "id": "R-BTA-9013408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013408", "resource": "Reactome", "description": "RHOG GTPase cycle" }, { "id": "R-BTA-9837999", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9837999", "resource": "Reactome", "description": "Mitochondrial protein degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZNN4-1", "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial", "gene_name": "NDUFS3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAAAAARGCWRGLVGPAAVARVSGRPSVLLLPVRKESAAADTRPTIRPRNDVVHKQLSAFGQYVAEILPKYVQQVQVSCFNELEIFIHPDGVIPVLTFLRDHTNAQFKSLADLTAVDVPTRQNRFEIVYNLLSLRFNSRIRVKTYTDELTPIESSVTVYKAANWYEREIWDMFGVFFANHPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPAYRQPPEDLKLEAGDKKPETK", "length": 264 }, "evidence": [ { "id": "F1MS25", "url": "https://omabrowser.org/oma/group/F1MS25/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1A222-1", "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial", "gene_name": "NDUFS3", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPPGMESPLPPWQPAPTPNHPFHEKIHPHTQPKPPLVQLEALSSHPITFHTRRVTTNPSHCNLLSATVRPKNEVEQKQLCAFGEYVAEILPKYIQQVQVTCFNELELLIHPDGIIPVLTFLRDHTNAQFKSLADLTAVDVPSRQYRFEIVYNLLSLRFNSRIRVKTYTDELTPIDSAVSVHKAANWYEREVWDMYGVFFANHPDLRRILTDYGFEGHPFRKDFPLSGYVEVRYDDEVKRVVAEPVELSQEFRKFDLNSPWEAFPAYRAPPEPLKIEAGAKKEDAK", "length": 285 }, "evidence": [ { "id": "F1MS25", "url": "https://omabrowser.org/oma/group/F1MS25/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZG43-1", "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial", "gene_name": "Ndufs3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MISKPNNLDIQLMRLRRSIIRPKKKKKEEVNEIRNPDPEPLLPAPCPPGRRFIAHFHFRSVPLRLRGLCVFSGYLVGTLRNMASAAARVWCRGLLGAASVARGAGRPSVLLQQRVRRESAAADKRPTVRPSSDVTHKRLSAFGEYVAEILPKYVQQVQVTCFDELEICIHPDGVIPTITFLKDHTNAQFKSLADLTAVDVPTRQNRFEIVYNLLSLRFNSRIRVKTYADELTAIDSIVSVHIAANWYEREVWDMFGVFFFNHPDLRRILTDYGFEGHPFRKDFPLTGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPAYRQPPEHLKLEAGDKKPEAK", "length": 345 }, "evidence": [ { "id": "F1MS25", "url": "https://omabrowser.org/oma/group/F1MS25/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3GYL3-1", "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial", "gene_name": "Ndufs3", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAAAAARVWWRGLVGAASVARGTGRPSALLQRVRRESAAADTRPTVRPKNDVTHKQLSAFGEYVAEILPKYVQQVQVTCFNELEICIHPDGVIPVLTFLKDHTNAQFKSLADMTAVDVPTRQNRFEIVYNLLSLRFNSRIRVKTYADELTPIESVVSVHKAANWYEREVWDMFGVFFVNHPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPAYRQPPESLKLEAGDKKPEAK", "length": 263 }, "evidence": [ { "id": "F1MS25", "url": "https://omabrowser.org/oma/group/F1MS25/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O75489-1", "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial", "gene_name": "NDUFS3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAAAVARLWWRGILGASALTRGTGRPSVLLLPVRRESAGADTRPTVRPRNDVAHKQLSAFGEYVAEILPKYVQQVQVSCFNELEVCIHPDGVIPVLTFLRDHTNAQFKSLVDLTAVDVPTRQNRFEIVYNLLSLRFNSRIRVKTYTDELTPIESAVSVFKAANWYEREIWDMFGVFFANHPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPVYRQPPESLKLEAGDKKPDAK", "length": 264 }, "evidence": [ { "id": "F1MS25", "url": 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"MQKSGSPRSRPAGVGDHLEAGPQRRGRASGAKTGRAAAPAHSGHRACKRGPGRAAGHLADGGQRAQQQRPPPRGSSADPPAAAAALGLLPPGPRPEPRWRSLSPAARPGGMEPGAARESSARHGDGRKKMAAAVAAAAAAASSHAPLTPMARAGRRAADGGGGGGGPGSAEGRGEAGRGPAGGGGRAGAWREAVGTVCCARNMAGVGDAAAPREGGADGAERDGRAEAEQLGGGGHGPPPAPQHTETLGFYESDRRRERRRSRAELSLFRFLSAELTRGYFLEHNEAKYTERRERVYTCMRIPRELEKLMVFGIFLCLDAFLYVFTLLPVRVFLALFRLFTLPCYGLRDRRVLQPAQVCDVLKGVILVICYCMMHYVDYSMMYHLIRGQSVIKLYIIYNMLEVADRLFSSFGQDILDALYWTATEPKERRRAHIGVAPHFFMAVLYVFLHAILIMVQATTLNVAFNSHNKSLLTIMMSNNFVEIKGSVFKKFEKNNLFQMSNSDIKERFTNYVLLLIVCLRNMEQFSWNPDHLWVLFPDVCMVVASEIAVDIVKHAFITKFNDITADVYSEYRASLAFDLVSSRQKNAYTDYSDSVARRMGFIPLPLAVLLIRVVTSSVKVQGILSYACVILFYLGLISLKVLNSIVLLGKSCQYVKEAKMEDKLFNPPPASAPGKPSSKSQNKCKSSQEETLSASVTSQPTHQKENAIPLLVTSSSDQLLTTPDGDEKDITQENSELKHRSSKKDLLEVDRFTICGNRID", "length": 761, "header": "tr|F1MN55-1|F1MN55_BOVIN Isoform 1 of Transmembrane anterior posterior transformation 1 OS=Bos taurus OX=9913 GN=TAPT1 PE=3 SV=4 CANONICAL=F1MN55-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZ59-1", "url": 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CANONICAL=F1MN55-1" }, "locus": { "chromosome": "6", "start_pos": 111425864, "end_pos": 111366490, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127424.1", "url": "https://www.ensembl.org/id/ENSBTAT00000127424.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077921.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077921.1" } ] } }, { "isoform_ac": "F1MN55-1", "url": "https://www.uniprot.org/uniprotkb/F1MN55/entry", "sequence": { "sequence": "MQKSGSPRSRPAGVGDHLEAGPQRRGRASGAKTGRAAAPAHSGHRACKRGPGRAAGHLADGGQRAQQQRPPPRGSSADPPAAAAALGLLPPGPRPEPRWRSLSPAARPGGMEPGAARESSARHGDGRKKMAAAVAAAAAAASSHAPLTPMARAGRRAADGGGGGGGPGSAEGRGEAGRGPAGGGGRAGAWREAVGTVCCARNMAGVGDAAAPREGGADGAERDGRAEAEQLGGGGHGPPPAPQHTETLGFYESDRRRERRRSRAELSLFRFLSAELTRGYFLEHNEAKYTERRERVYTCMRIPRELEKLMVFGIFLCLDAFLYVFTLLPVRVFLALFRLFTLPCYGLRDRRVLQPAQVCDVLKGVILVICYCMMHYVDYSMMYHLIRGQSVIKLYIIYNMLEVADRLFSSFGQDILDALYWTATEPKERRRAHIGVAPHFFMAVLYVFLHAILIMVQATTLNVAFNSHNKSLLTIMMSNNFVEIKGSVFKKFEKNNLFQMSNSDIKERFTNYVLLLIVCLRNMEQFSWNPDHLWVLFPDVCMVVASEIAVDIVKHAFITKFNDITADVYSEYRASLAFDLVSSRQKNAYTDYSDSVARRMGFIPLPLAVLLIRVVTSSVKVQGILSYACVILFYLGLISLKVLNSIVLLGKSCQYVKEAKMEDKLFNPPPASAPGKPSSKSQNKCKSSQEETLSASVTSQPTHQKENAIPLLVTSSSDQLLTTPDGDEKDITQENSELKHRSSKKDLLEVDRFTICGNRID", "length": 761, "header": "tr|F1MN55-1|F1MN55_BOVIN Isoform 1 of Transmembrane anterior posterior transformation 1 OS=Bos taurus OX=9913 GN=TAPT1 PE=3 SV=4 CANONICAL=F1MN55-1" }, "locus": { "chromosome": "6", "start_pos": 111425864, "end_pos": 111366490, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025911.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025911.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025911.7", "url": "https://www.ensembl.org/id/ENSBTAP00000025911.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:615598", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:615598", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MN55", "url": "https://www.uniprot.org/uniprotkb/F1MN55" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1MN55", "url": "https://www.uniprot.org/uniprotkb/F1MN55" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1MN55", "url": "https://www.uniprot.org/uniprotkb/F1MN55" } ], "pmid": "" }, { "name": "ciliary basal body", "id": "GO:0036064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "evidence": [ { "database": "UniProtKB", "id": "F1MN55", "url": "https://www.uniprot.org/uniprotkb/F1MN55" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "ossification", "id": "GO:0001503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001503", "evidence": [ { "database": "UniProtKB", "id": "F1MN55", "url": "https://www.uniprot.org/uniprotkb/F1MN55" } ], "pmid": "" }, { "name": "cartilage development", "id": "GO:0051216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051216", "evidence": [ { "database": "UniProtKB", "id": "F1MN55", "url": "https://www.uniprot.org/uniprotkb/F1MN55" } ], "pmid": "" }, { "name": "positive regulation of cilium assembly", "id": "GO:0045724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045724", "evidence": [ { "database": "UniProtKB", "id": "F1MN55", "url": "https://www.uniprot.org/uniprotkb/F1MN55" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 469, "end_pos": 471, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MN55-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 761, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MN55-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MN55" } ], "lectin_list": [], "domain_list": [], 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"Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GPAT2", "url": "https://www.uniprot.org/uniprotkb/F1MLW9", "locus": { "chromosome": "11", "start_pos": 2164621, "end_pos": 2176747, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011558", "url": "https://www.ensembl.org/id/ENSBTAG00000011558" } ] } } ], "crossref": [ { "id": "F1MLW9", "url": "https://alphafold.ebi.ac.uk/entry/F1MLW9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011558", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011558", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "526739", "url": "https://www.ncbi.nlm.nih.gov/gene/526739", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002123", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002123", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022284", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022284", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045520", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045520", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MLW9", "url": "https://www.orthodb.org/?gene=F1MLW9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12563", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12563", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12563:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12563:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF19277", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19277", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1483166", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483166", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-75109", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75109", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_059747280", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747280", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9RZX3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZX3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAQ0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUY3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SUY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUY3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYR6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYR6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYR6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF35", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF35", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TF35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF35-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKM4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKM4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKM4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWL5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLW9", "url": "https://www.uniprot.org/uniprotkb/F1MLW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLW9-1", "url": "https://www.uniprot.org/uniprotkb/F1MLW9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNTMAEARLQTQKKSSQDGQETSLWSSGFGMKLEAVTPFLGKYRPFVGRCCQTCTPKSWESLFHRSIMDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPPCQDASQKIMESTGVQNVISGRAPGGAGEGQVPSHVRKEVQRILGHIQAPPRPFLLRLFSWALLRFLNCLFLNVQLYRGQMKMVQKASQAGSPLVFLSTHKSVLDGILLPFVLLSQGVGVLRVAWDPRTCSPLLRALLKKLGGLFLPPEANLSPDSPEGVLARAVVHATVEQLLASRQPLLIFLEEPPGVRGPRLSALGLSWLGLVVQGVQAGIVPDTLLVPVAVTYDLVPEAPHDTCHALAPLGLWTGALAVLRSLRRWGCGRRVCVRVNLAQPFSLQEYIIDARSCWGSRQTLEQLLQPIVLGQCTAVPDTEKEQEWTPVTGPLLALREEDQLLVRRLSWHVLNASVASSAVMSTAIMATLLLFKHQKGVFLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLVQHTLSLLRPHVALLRIQQGDLLVVPRPGPGLTSLARLSAELLPTFLSEAVGACAVRGLLAGRVPPEGPWELQGVELLSQKELYCQILLLLHLLPQDLLLLQPCQSCYCYCQEVLDRLIQCGLLVAEETRGSQPACDTGRQRLSARLLWKLSGDFTDSDSDDFEEAEGRYFRLSQQSRCPDFFLFLCRLLSPVLKAFAQAAAFLHRGRLPDTESGYTEQLFQFLRATAQEEGLFECADPNLAISAIWTFRDLGVLQQTPGPTGPMLHLSPAFASRDSQEKLGQFIRQFICS", "length": 800, "header": "tr|F1MLW9-1|F1MLW9_BOVIN Isoform 1 of Glycerol-3-phosphate acyltransferase 2, mitochondrial OS=Bos taurus OX=9913 GN=GPAT2 PE=4 SV=4 CANONICAL=F1MLW9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZX3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZX3/entry", "sequence": { "sequence": "MNTMAEARLQTQKKSSQDGQETSLWSSGFGMKLEAVTPFLGKYRPFVGRCCQTCTPKSWESLFHRSIMDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPPCQDASQKIMESTGVQNVISGRAPGGAGEGQVPSHVRKEVQRILGHIQAPPRPFLLRLFSWALLRFLNCLFLNVQLYRGQMKMVQKASQAGSPLVFLSTHKSVLDGILLPFVLLSQGVGVLRVAWDPRTCSPLLRALLKKLGGLFLPPEANLSPDSPEGVLARAVVHATVEQLLASRQPLLIFLEEPPGVRGPRLSALGLSWLGLVVQGVQAGIVPDTLLVPVAVTYDLVPEAPHDTCHEYIIDARSCWGSRQTLEQLLQPIVLGQCTAVPDTEKEQEWTPVTGPLLALREEDQLLVRRLSWHVLNASVASSAVMSTAIMATLLLFKHQKGVFLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLVQHTLSLLRPHVALLRIQQGDLLVVPRPGPGLTSLARLSAELLPTFLSEAVGACAVRGLLAGRVPPEGPWELQGVELLSQKELYCQILLLLHLLPQDLLLLQPCQSCYCYCQEVLDRLIQCGLLVAEETRGSQPACDTGRQRLSARLLWKLSGDFTDSDSDDFEEAEGRYFRLSQQSRCPDFFLFLCRLLSPVLKAFAQAAAFLHRGRLPDTESGYTEQLFQFLRATAQEEGLFECADPNLAISAIWTFRDLGVLQQTPGPTGPMLHLSPAFASRDSQEKLGQFIRQFICS", "length": 760, "header": "tr|A0AAA9RZX3-1|F1MLW9_BOVIN Computationally mapped isoform of Glycerol-3-phosphate acyltransferase 2, mitochondrial OS=Bos taurus OX=9913 GN=GPAT2 PE=4 SV=1 CANONICAL=F1MLW9-1" }, "locus": { "chromosome": "11", "start_pos": 2174030, "end_pos": 2164798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134321.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134321.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078209.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078209.1" } ] } }, { "isoform_ac": "A0AAA9SAQ0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAQ0/entry", "sequence": { "sequence": "MNTMAEARLQTQKKSSQDGQETSLWSSGFGMKLEAVTPFLGKYRPFVGRCCQTCTPKSWESLFHRSIMDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPPCQDASQKIMESTGVQNVISGRAPGGAGEGQVPSHVRKEVQRILGHIQAPPRPFLLRLFSWALLRFLNCLFLNVQLYRGQMKMVQKASQAGSPLVFLSTHKSVLDGILLPFVLLSQGVGVLRVAWDPRTCSPLLRALLKKLGGLFLPPEANLSPDSPEGVLARAVVHATVEQLLASRQPLLIFLEEPPGVRGPRLSALGLSWLGLVVQGVQAGIVPDTLLVPVAVTYDLVPEAPHDTCHALAPLGLWTGALAVLRSLRRWGCGRRVCVRVNLAQPFSLQEYIIDARSCWGSRQTLEQLLQPIVLGQCTAVPDTEKEQEWTPVTGPLLALREEDQLLVRRLSWHVLNASVASSAVMSTAIMATLLLFKHQKLLGEFSWLTEETLLRGFDVGFSGQLRCLVQHTLSLLRPHVALLRIQQGDLLVVPRPGPGLTSLARLSAELLPTFLSEAVGACAVRGLLAGRVPPEGPWELQGVELLSQKELYCQILLLLHLLPQDLLLLQPCQSCYCYCQEVLDRLIQCGLLVAEESPATRSSCSSSYGPQPRRKGSSSVRTQILPSVPSGPSETWGCCSRRPAPQAPCSTCPLPSPAGIARKSWDSSSGSSSVARTVGRSPCRDFSALDRSPALRQKTY", "length": 735, "header": "tr|A0AAA9SAQ0-1|F1MLW9_BOVIN Computationally mapped isoform of Glycerol-3-phosphate acyltransferase 2, mitochondrial OS=Bos taurus OX=9913 GN=GPAT2 PE=4 SV=1 CANONICAL=F1MLW9-1" }, "locus": { "chromosome": "11", "start_pos": 2174030, "end_pos": 2164722, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091875.1", "url": "https://www.ensembl.org/id/ENSBTAT00000091875.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079245.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079245.1" } ] } }, { "isoform_ac": "A0AAA9SUY3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SUY3/entry", "sequence": { "sequence": "MNTMAEARLQTQKKSSQDGQETSLWSSGFGMKLEAVTPFLGKYRPFVGRCCQTCTPKSWESLFHRSIMDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPPCQDASQKIMESTGVQNVISGRAPGGAGEGQVPSHVRKEVQRILGHIQAPPRPFLLRALLKKLGGLFLPPEANLSPDSPEGVLARAVVHATVEQLLASRQPLLIFLEEPPGVRGPRLSALGLSWLGLVVQGVQAGIVPDTLLVPVAVTYDLVPEAPHDTCHALAPLGLWTGALAVLRSLRRWGCGRRVCVRVNLAQPFSLQEYIIDARSCWGSRQTLEQLLQPIVLGQCTAVPDTEKEQEWTPVTGPLLALREEDQLLVRRLSWHVLNASVASSAVMSTAIMATLLLFKHQKGVFLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLVQHTLSLLRPHVALLRIQQGDLLVVPRPGPGLTSLARLSAELLPTFLSEAVGACAVRGLLAGRVPPEGPWELQGVELLSQKELYCQILLLLHLLPQDLLLLQPCQSCYCYCQEVLDRLIQCGLLVAEETRGSQPACDTGRQRLSARLLWKLSGDFTDSDSDDFEEAEGRYFRLSQQSRCPDFFLFLCRLLSPVLKAFAQAAAFLHRGRLPDTESGYTEQLFQFLRATAQEEGLFECADPNLAISAIWTFRDLGVLQQTPGPTGPMLHLSPAFASRDSQEKLGQFIRQFICS", "length": 722, "header": "tr|A0AAA9SUY3-1|F1MLW9_BOVIN Computationally mapped isoform of Glycerol-3-phosphate acyltransferase 2, mitochondrial OS=Bos taurus OX=9913 GN=GPAT2 PE=4 SV=1 CANONICAL=F1MLW9-1" }, "locus": { "chromosome": "11", "start_pos": 2174030, "end_pos": 2164798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134640.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134640.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090277.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090277.1" } ] } }, { "isoform_ac": "A0AAA9SYR6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYR6/entry", "sequence": { "sequence": "MNTMAEARLQTQKKSSQDGQEESLFHRSIMDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPPCQDASQKIMESTGVQNVISGRAPGGAGEGQVPSHVRKEVQRILGHIQAPPRPFLLRLFSWALLRFLNCLFLNVQLYRGQMKMVQKASQAGSPLVFLSTHKSVLDGILLPFVLLSQGVGVLRVAWDPRTCSPLLRALLKKLGGLFLPPEANLSPDSPEGVLARAVVHATVEQLLASRQPLLIFLEEPPGVRGPRLSALGLSWLGLVVQGVQAGIVPDTLLVPVAVTYDLVPEAPHDTCHALAPLGLWTGALAVLRSLRRWGCGRRVCVRVNLAQPFSLQEYIIDARSCWGSRQTLEQLLQPIVLGQCTAVPDTEKEQEWTPVTGPLLALREEDQLLVRRLSWHVLNASVASSAVMSTAIMATLLLFKHQKGVFLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLVQHTLSLLRPHVALLRIQQGDLLVVPRPGPGLTSLARLSAELLPTFLSEAVGACAVRGLLAGRVPPEGPWELQGVELLSQKELYCQILLLLHLLPQDLLLLQPCQSCYCYCQEVLDRLIQCGLLVAEETRGSQPACDTGRQRLSARLLWKLSGDFTDSDSDDFEEAEGRYFRLSQQSRCPDFFLFLCRLLSPVLKAFAQAAAFLHRGRLPDTESGYTEQLFQFLRATAQEEGLFECADPNLAISAIWTFRDLGVLQQTPGPTGPMLHLSPAFASRDSQEKLGQFIRQFICS", "length": 762, "header": "tr|A0AAA9SYR6-1|F1MLW9_BOVIN Computationally mapped isoform of Glycerol-3-phosphate acyltransferase 2, mitochondrial OS=Bos taurus OX=9913 GN=GPAT2 PE=4 SV=1 CANONICAL=F1MLW9-1" }, "locus": { "chromosome": "11", "start_pos": 2174030, "end_pos": 2164798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133418.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133418.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090512.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090512.1" } ] } }, { "isoform_ac": "A0AAA9TF35-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TF35/entry", "sequence": { "sequence": "MNTMAEARLQTQKKSSQDGQETSLWSSGFGMKLEAVTPFLGKYRPFVGRCCQTCTPKSWESLFHRSIMDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPPCQDASQKIMESTGLFSWALLRFLNCLFLNVQLYRGQMKMVQKASQAGSPLVFLSTHKSVLDGILLPFVLLSQGVGVLRVAWDPRTCSPLLRALLKKLGGLFLPPEANLSPDSPEGVLARAVVHATVEQLLASRQPLLIFLEEPPGVRGPRLSALGLSWLGLVVQGVQAGIVPDTLLVPVAVTYDLVPEAPHDTCHALAPLGLWTGALAVLRSLRRWGCGRRVCVRVNLAQPFSLQEYIIDARSCWGSRQTLEQLLQPIVLGQCTAVPDTEKEQEWTPVTGPLLALREEDQLLVRRLSWHVLNASVASSAVMSTAIMATLLLFKHQKGVFLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLVQHTLSLLRPHVALLRIQQGDLLVVPRPGPGLTSLARLSAELLPTFLSEAVGACAVRGLLAGRVPPEGPWELQGVELLSQKELYCQILLLLHLLPQDLLLLQPCQSCYCYCQEVLDRLIQCGLLVAEETRGSQPACDTGRQRLSARLLWKLSGDFTDSDSDDFEEAEGRYFRLSQQSRCPDFFLFLCRLLSPVLKAFAQAAAFLHRGRLPDTESGYTEQLFQFLRATAQEEGLFECADPNLAISAIWTFRDLGVLQQTPGPTGPMLHLSPAFASRDSQEKLGQFIRQFICS", "length": 757, "header": "tr|A0AAA9TF35-1|F1MLW9_BOVIN Computationally mapped isoform of Glycerol-3-phosphate acyltransferase 2, mitochondrial OS=Bos taurus OX=9913 GN=GPAT2 PE=4 SV=1 CANONICAL=F1MLW9-1" }, "locus": { "chromosome": "11", "start_pos": 2174030, "end_pos": 2164798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000122660.1", "url": "https://www.ensembl.org/id/ENSBTAT00000122660.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095459.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095459.1" } ] } }, { "isoform_ac": "A0AAA9TKM4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKM4/entry", "sequence": { "sequence": "MNTMAEARLQTQKKSSQDGQETSLWSSGFGMKLEAVTPFLGKYRPFVGRCCQTCTPKSWESLFHRSIMDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPPCQDASQKIMESTGVQNVISGRAPGGAGEGQVPSHVRKEVQRILGHIQAPPRPFLLRTVVVPALEEFWAAHTSDWALLCRLFSWALLRFLNCLFLNVQLYRGQMKMVQKASQAGSPLVFLSTHKSVLDGILLPFVLLSQGVGVLRVAWDPRTCSPLLRALLKKLGGLFLPPEANLSPDSPEGVLARAVVHATVEQLLASRQPLLIFLEEPPGVRGPRLSALGLSWLGLVVQGVQAGIVPDTLLVPVAVTYDLVPEAPHDTCHALAPLGLWTGALAVLRSLRRWGCGRRVCVRVNLAQPFSLQEYIIDARSCWGSRQTLEQLLQPIVLGQCTAVPDTEKEQEWTPVTGPLLALREEDQLLVRRLSWHVLNASVASSAVMSTAIMATLLLFKHQKGVFLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLVQHTLSLLRPHVALLRIQQGDLLVVPRPGPGLTSLARLSAELLPTFLSEAVGACAVRGLLAGRVPPEGPWELQGVELLSQKELYCQILLLLHLLPQDLLLLQPCQSCYCYCQEVLDRLIQCGLLVAEETRGSQPACDTGRQRLSARLLWKLSGDFTDSDSDDFEEAEGRYFRLSQQSRCPDFFLFLCRLLSPVLKAFAQAAAFLHRGRLPDTESGYTEQLFQFLRATAQEEGLFECADPNLAISAIWTFRDLGVLQQTPGPTGPMLHLSPAFASRDSQEKLGQFIRQFICS", "length": 823, "header": "tr|A0AAA9TKM4-1|F1MLW9_BOVIN Computationally mapped isoform of Glycerol-3-phosphate acyltransferase 2, mitochondrial OS=Bos taurus OX=9913 GN=GPAT2 PE=4 SV=1 CANONICAL=F1MLW9-1" }, "locus": { "chromosome": "11", "start_pos": 2174030, "end_pos": 2164798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113377.1", "url": "https://www.ensembl.org/id/ENSBTAT00000113377.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096817.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096817.1" } ] } }, { "isoform_ac": "A0AAA9TWL5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWL5/entry", "sequence": { "sequence": "MNTMAEARLQTQKKSSQDGQETSLWSSGFGMKLEAVTPFLGKYRPFVGRCCQTCTPKSWESLFHRSIMDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPPCQDASQKIMESTGVQNVISGRAPGGAGEGQVPSHVRKEVQRILGHIQAPPRPFLLRLFSWALLRFLNCLFLNVQLYRGQMKMVQKASQAGSPLVFLSTHKSVLDGILLPFVLLSQGVGVLRVAWDPRTCSPLLRALLKKLGGLFLPPEANLSPDSPEGVLARAVVHAALAPLGLWTGALAVLRSLRRWGCGRRVCVRVNLAQPFSLQEYIIDARSCWGSRQTLEQLLQPIVLGQCTAVPDTEKEQEWTPVTGPLLALREEDQLLVRRLSWHVLNASVASSAVMSTAIMATLLLFKHQKLLGEFSWLTEETLLRGFDVGFSGQLRCLVQHTLSLLRPHVALLRIQQGDLLVVPRPGPGLTSLARLSAELLPTFLSEAVGACAVRGLLAGRVPPEGPWELQGVELLSQKELYCQILLLLHLLPQDLLLLQPCQSCYCYCQEVLDRLIQCGLLVAEETRGSQPACDTGRQRLSARLLWKLSGDFTDSDSDDFEEAEGRYFRLSQQSRCPDFFLFLCRLLSPVLKAFAQAAAFLHRGRLPDTESGYTEQLFQFLRATAQEEGLFECADPNLAISAIWTFRDLGVLQQTPGPTGPMLHLSPAFASRDSQEKLGQFIRQFICS", "length": 723, "header": "tr|A0AAA9TWL5-1|F1MLW9_BOVIN Computationally mapped isoform of Glycerol-3-phosphate acyltransferase 2, mitochondrial OS=Bos taurus OX=9913 GN=GPAT2 PE=4 SV=1 CANONICAL=F1MLW9-1" }, "locus": { "chromosome": "11", "start_pos": 2174030, "end_pos": 2164798, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107284.1", "url": "https://www.ensembl.org/id/ENSBTAT00000107284.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102736.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102736.1" } ] } }, { "isoform_ac": "F1MLW9-1", "url": "https://www.uniprot.org/uniprotkb/F1MLW9/entry", "sequence": { "sequence": "MNTMAEARLQTQKKSSQDGQETSLWSSGFGMKLEAVTPFLGKYRPFVGRCCQTCTPKSWESLFHRSIMDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPPCQDASQKIMESTGVQNVISGRAPGGAGEGQVPSHVRKEVQRILGHIQAPPRPFLLRLFSWALLRFLNCLFLNVQLYRGQMKMVQKASQAGSPLVFLSTHKSVLDGILLPFVLLSQGVGVLRVAWDPRTCSPLLRALLKKLGGLFLPPEANLSPDSPEGVLARAVVHATVEQLLASRQPLLIFLEEPPGVRGPRLSALGLSWLGLVVQGVQAGIVPDTLLVPVAVTYDLVPEAPHDTCHALAPLGLWTGALAVLRSLRRWGCGRRVCVRVNLAQPFSLQEYIIDARSCWGSRQTLEQLLQPIVLGQCTAVPDTEKEQEWTPVTGPLLALREEDQLLVRRLSWHVLNASVASSAVMSTAIMATLLLFKHQKGVFLSQLLGEFSWLTEETLLRGFDVGFSGQLRCLVQHTLSLLRPHVALLRIQQGDLLVVPRPGPGLTSLARLSAELLPTFLSEAVGACAVRGLLAGRVPPEGPWELQGVELLSQKELYCQILLLLHLLPQDLLLLQPCQSCYCYCQEVLDRLIQCGLLVAEETRGSQPACDTGRQRLSARLLWKLSGDFTDSDSDDFEEAEGRYFRLSQQSRCPDFFLFLCRLLSPVLKAFAQAAAFLHRGRLPDTESGYTEQLFQFLRATAQEEGLFECADPNLAISAIWTFRDLGVLQQTPGPTGPMLHLSPAFASRDSQEKLGQFIRQFICS", "length": 800, "header": "tr|F1MLW9-1|F1MLW9_BOVIN Isoform 1 of Glycerol-3-phosphate acyltransferase 2, mitochondrial OS=Bos taurus OX=9913 GN=GPAT2 PE=4 SV=4 CANONICAL=F1MLW9-1" }, "locus": { 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"pmid": "" }, { "name": "piRNA processing", "id": "GO:0034587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034587", "evidence": [ { "database": "UniProtKB", "id": "F1MLW9", "url": "https://www.uniprot.org/uniprotkb/F1MLW9" } ], "pmid": "" }, { "name": "glycerophospholipid metabolic process", "id": "GO:0006650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006650", "evidence": [ { "database": "UniProtKB", "id": "F1MLW9", "url": "https://www.uniprot.org/uniprotkb/F1MLW9" } ], "pmid": "" }, { "name": "triglyceride biosynthetic process", "id": "GO:0019432", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019432", "evidence": [ { "database": "UniProtKB", "id": "F1MLW9", "url": "https://www.uniprot.org/uniprotkb/F1MLW9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "O-acyltransferase activity", "id": "GO:0008374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008374", "evidence": [ { "database": "UniProtKB", "id": "F1MLW9", "url": 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"sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJR4-1", "uniprot_ac": "F1MJR4", "uniprot_id": "F1MJR4_BOVIN", "mass": { "chemical_mass": 64382.0, "monoisotopic_mass": 64382.0 }, "refseq": {}, "gene_names": [ { "name": "IL22RA1", "type": "recommended", "evidence": [ { "id": "F1MJR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJR4" } ] } ], "protein_names": [ { "name": "Interleukin-22 receptor subunit alpha-1", "type": "recommended", "evidence": [ { "id": "F1MJR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJR4/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.", "evidence": [ { "database": "UniProtKB", "id": "F1MJR4", "url": "https://www.uniprot.org/uniprotkb/F1MJR4#function" }, { "database": "UniProtKB", "id": "ARBA00055421", "url": "https://www.uniprot.org/uniprotkb/ARBA00055421#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJR4", "url": "https://www.uniprot.org/uniprotkb/F1MJR4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL22RA1", "url": "https://www.uniprot.org/uniprotkb/F1MJR4", "locus": { "chromosome": "2", "start_pos": 128780184, "end_pos": 128753566, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000001100", "url": 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"https://www.ebi.ac.uk/interpro/entry/IPR050650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MJR4", "url": "https://www.orthodb.org/?gene=F1MJR4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR20859", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20859", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR20859:SF53", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20859:SF53", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01108", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01108", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF09294", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF09294", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-8854691", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854691", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9RZY4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9RZY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJR4", "url": "https://www.uniprot.org/uniprotkb/F1MJR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJR4-1", "url": "https://www.uniprot.org/uniprotkb/F1MJR4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRTLLTILAAGSLLAHITEDTSDLLQHVKFQSSNFENILTWDGRPESAPDTVYSVQYKTPSLAHRYGEEEWLEKEGCQRITQKSCNLTMETSNLTELYYARVTATDGAGRSATKMTNRFSSLQHTSIKPPDVTCIPKVRSIQMIVHPTYTPIRAQNGHQLTLENIFQDLLYHLKLRINHTYQMHLEGKQREFEFVGLTPDTEFLGTIMICIPNLFKESAPYMCRVKTLPDRTWTYSFSGAFLFSLGFLVAGLCYLSYRYITKPPPPPSSLNVQHILPFRPLQFIQEHTLIPVFDLSGSGGLAQPVQYSEVKVSNPTEPPGPPPRHSLPEIAYLGQPDLPVLRPSGGPPHQALPVLSYAPQAAPEGRPSSYAPQGALEAKPPSYTPQAVSETQLPSYTPRATPDNWPPSYGMCGEGSGRDSPPVTRSGPKHLGTKGQLQKEVPAGSCSPTGLSLQEVTPLAMEDPQEAKSSHQCLRVHTDSDSDSDTIGQREPGTRSSLKGQLPLLSSVQIEGHPGCLPLQTPSLPCSPTDKGPSPWGLLESLVCPSDEDPVSKTEAESPGLQAPDLESPTELDSLFRGLALTVQWES", "length": 587, "header": "tr|F1MJR4-1|F1MJR4_BOVIN Isoform 1 of Interleukin-22 receptor subunit alpha-1 OS=Bos taurus OX=9913 GN=IL22RA1 PE=3 SV=3 CANONICAL=F1MJR4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9RZY4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RZY4/entry", "sequence": { "sequence": "MGRYGEEEWLEKEGCQRITQKSCNLTMETSNLTELYYARVTATDGAGRSATKMTNRFSSLQHTSIKPPDVTCIPKVRSIQMIVHPTYTPIRAQNGHQLTLENIFQDLLYHLKLRINHTYQMHLEGKQREFEFVGLTPDTEFLGTIMICIPNLFKESAPYMCRVKTLPDRTWTYSFSGAFLFSLGFLVAGLCYLSYRYITKPPPPPSSLNVQHILPFRPLQFIQEHTLIPVFDLSGSGGLAQPVQYSEVKVSNPTEPPGPPPRHSLPEIAYLGQPDLPVLRPSGGPPHQALPVLSYAPQAAPEGRPSSYAPQGALEAKPPSYTPQAVSETQLPSYTPRATPDNWPPSYGMCGEGSGRDSPPVTRSGPKHLGTKGQLQKEVPAGSCSPTGLSLQEVTPLAMEDPQEAKSSHQCLRVHTDSDSDSDTIGQREPGTRSSLKGQLPLLSSVQIEGHPGCLPLQTPSLPCSPTDKGPSPWGLLESLVCPSDEDPVSKTEAESPGLQAPDLESPTELDSLFRGLALTVQWES", "length": 525, "header": "tr|A0AAA9RZY4-1|F1MJR4_BOVIN Computationally mapped isoform of Interleukin-22 receptor subunit alpha-1 OS=Bos taurus OX=9913 GN=IL22RA1 PE=3 SV=1 CANONICAL=F1MJR4-1" }, "locus": { "chromosome": "2", "start_pos": 128779176, "end_pos": 128754168, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098169.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098169.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076645.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076645.1" } ] } }, { "isoform_ac": "F1MJR4-1", "url": "https://www.uniprot.org/uniprotkb/F1MJR4/entry", "sequence": { "sequence": "MRTLLTILAAGSLLAHITEDTSDLLQHVKFQSSNFENILTWDGRPESAPDTVYSVQYKTPSLAHRYGEEEWLEKEGCQRITQKSCNLTMETSNLTELYYARVTATDGAGRSATKMTNRFSSLQHTSIKPPDVTCIPKVRSIQMIVHPTYTPIRAQNGHQLTLENIFQDLLYHLKLRINHTYQMHLEGKQREFEFVGLTPDTEFLGTIMICIPNLFKESAPYMCRVKTLPDRTWTYSFSGAFLFSLGFLVAGLCYLSYRYITKPPPPPSSLNVQHILPFRPLQFIQEHTLIPVFDLSGSGGLAQPVQYSEVKVSNPTEPPGPPPRHSLPEIAYLGQPDLPVLRPSGGPPHQALPVLSYAPQAAPEGRPSSYAPQGALEAKPPSYTPQAVSETQLPSYTPRATPDNWPPSYGMCGEGSGRDSPPVTRSGPKHLGTKGQLQKEVPAGSCSPTGLSLQEVTPLAMEDPQEAKSSHQCLRVHTDSDSDSDTIGQREPGTRSSLKGQLPLLSSVQIEGHPGCLPLQTPSLPCSPTDKGPSPWGLLESLVCPSDEDPVSKTEAESPGLQAPDLESPTELDSLFRGLALTVQWES", "length": 587, "header": "tr|F1MJR4-1|F1MJR4_BOVIN Isoform 1 of Interleukin-22 receptor subunit alpha-1 OS=Bos taurus OX=9913 GN=IL22RA1 PE=3 SV=3 CANONICAL=F1MJR4-1" }, "locus": { "chromosome": "2", "start_pos": 128779176, "end_pos": 128753746, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001455.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001455.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001455.5", "url": "https://www.ensembl.org/id/ENSBTAP00000001455.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-8854691", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8854691", "resource": "Reactome", "description": "Interleukin-20 family signaling" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MJR4", "url": "https://www.uniprot.org/uniprotkb/F1MJR4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MJR4", "url": "https://www.uniprot.org/uniprotkb/F1MJR4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of inflammatory response", "id": "GO:0050728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050728", "evidence": [ { "database": "UniProtKB", "id": "F1MJR4", "url": "https://www.uniprot.org/uniprotkb/F1MJR4" } ], "pmid": "" }, { "name": "cytokine-mediated signaling pathway", "id": "GO:0019221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019221", "evidence": [ { "database": "UniProtKB", "id": "F1MJR4", "url": "https://www.uniprot.org/uniprotkb/F1MJR4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "interleukin-22 receptor activity", "id": "GO:0042018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042018", "evidence": [ { "database": "UniProtKB", "id": "F1MJR4", "url": "https://www.uniprot.org/uniprotkb/F1MJR4" } ], "pmid": "" }, { "name": "cytokine receptor activity", "id": "GO:0004896", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004896", "evidence": [ { "database": "UniProtKB", "id": "F1MJR4", "url": "https://www.uniprot.org/uniprotkb/F1MJR4" } ], "pmid": "" }, { "name": "interleukin-20 binding", "id": "GO:0042015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042015", "evidence": [ { "database": "UniProtKB", "id": "F1MJR4", "url": "https://www.uniprot.org/uniprotkb/F1MJR4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 86, "end_pos": 88, "annotation": "n_glycosylation_sequon" }, { "start_pos": 93, "end_pos": 95, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": 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"total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MRD5-1", "uniprot_ac": "F1MRD5", "uniprot_id": "F1MRD5_BOVIN", "mass": { "chemical_mass": 61682.0, "monoisotopic_mass": 61682.0 }, "refseq": {}, "gene_names": [ { "name": "PUS10", "type": "recommended", "evidence": [ { "id": "F1MRD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRD5" } ] } ], "protein_names": [ { "name": "tRNA pseudouridine synthase Pus10", "type": "recommended", "evidence": [ { "id": "F1MRD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRD5/entry#names_and_taxonomy" } ] }, { "name": "5.4.99.25", "type": "synonym", "evidence": [ { "id": "F1MRD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRD5/entry#names_and_taxonomy" } ] }, { "name": "Coiled-coil domain-containing protein 139", "type": "synonym", "evidence": [ { "id": "F1MRD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRD5/entry#names_and_taxonomy" } ] }, { "name": "tRNA pseudouridine 55 synthase", "type": "synonym", "evidence": [ { "id": "F1MRD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRD5/entry#names_and_taxonomy" } ] }, { "name": "tRNA pseudouridylate synthase", "type": "synonym", "evidence": [ { "id": "F1MRD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRD5/entry#names_and_taxonomy" } ] }, { "name": "tRNA-uridine isomerase", "type": "synonym", "evidence": [ { "id": "F1MRD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRD5/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm. In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs. tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs. Does not show tRNA pseudouridylate synthase activity in the nucleus. In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity. Binds pri-miRNAs. Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.", "evidence": [ { "database": "UniProtKB", "id": "F1MRD5", "url": "https://www.uniprot.org/uniprotkb/F1MRD5#function" }, { "database": "UniProtKB", "id": "ARBA00057868", "url": "https://www.uniprot.org/uniprotkb/ARBA00057868#function" }, { "database": "UniProtKB", "id": "A0ABI0NXF9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXF9#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MRD5", "url": "https://www.uniprot.org/uniprotkb/F1MRD5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PUS10", "url": "https://www.uniprot.org/uniprotkb/F1MRD5", "locus": { "chromosome": "11", "start_pos": 43674599, "end_pos": 43760138, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009694", "url": "https://www.ensembl.org/id/ENSBTAG00000009694" } ] } } ], "crossref": [ { "id": "F1MRD5", "url": "https://alphafold.ebi.ac.uk/entry/F1MRD5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009694", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009694", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR020103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048741", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048741", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MRD5", "url": "https://www.orthodb.org/?gene=F1MRD5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21568", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21568", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21568:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21568:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF21237", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21237", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF21238", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21238", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "42532", "url": "https://www.rhea-db.org/rhea/42532", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "57876", "url": "https://www.rhea-db.org/rhea/57876", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9S0Q9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0Q9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S0Q9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0Q9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXF9", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NXF9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRD5", "url": "https://www.uniprot.org/uniprotkb/F1MRD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRD5-1", "url": "https://www.uniprot.org/uniprotkb/F1MRD5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFPLTVENKHVAQLLLSTGTCPRCIFRFCGVDFHAPYKLPYKELLRELQKFLEAEEDELVSEVPNPPPKKIRLQEPEDQIDGMDSLSQNGEGKLSVTEDGSSSSKNSNLNVCNVCLGILQDFCEKEFIKKVCQKVEASGFEFTNLVLSVSFPPQLSVREHAAWLLVKQEMGELIFMLFRKQSLSLGRNDIVQLKEAYKWITHPLFSEELGVPIDGKSLFEVSVVFAHPETVEDCHFLRAICPDCFKPAKNKQSVFTRMAVMKALNKIKEEDFCKQFPCPPNSPKAVCTVLEIECAHGAVFVAGRYNKYSRNLPQTPWIIDGERKLESSVEELISDHLLKVFKAESFNFSSSGREDVDVRTLGNGRPFAIELVNPHRVHFTSQEIKELQQKINNSSNKIQVRDLQLVTREAIGHMKEGEEEKTKTYSALIWTNKAIQRKDIEFLDDIKDLNIDQKTPLRVLHRRPLAVRTRIIHSMETRYVDEHHFRLYLKTQAGTYIKEFVHGDFGRTKPNIGSLMDVTADILELDVESVDVDWPPALDD", "length": 540, "header": "tr|F1MRD5-1|F1MRD5_BOVIN Isoform 1 of tRNA pseudouridine synthase Pus10 OS=Bos taurus OX=9913 GN=PUS10 PE=3 SV=4 CANONICAL=F1MRD5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S0Q9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S0Q9/entry", "sequence": { "sequence": "MFPLTVENKHVAQLLLSTGTCPRCIFRFCGVDFHAPYKLPYKMTKLRHREVKQPAQSYTAIK", "length": 62, "header": "tr|A0AAA9S0Q9-1|F1MRD5_BOVIN Computationally mapped isoform of tRNA pseudouridine synthase Pus10 OS=Bos taurus OX=9913 GN=PUS10 PE=3 SV=1 CANONICAL=F1MRD5-1" }, "locus": { "chromosome": "11", "start_pos": 43755495, "end_pos": 43754327, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119962.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119962.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000075656.1", "url": "https://www.ensembl.org/id/ENSBTAP00000075656.1" } ] } }, { "isoform_ac": "A0ABI0NXF9-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NXF9/entry", "sequence": { "sequence": "MFPLTVENKHVAQLLLSTGTCPRCIFRFCGVDFHAPYKLPYKELLRELQKFLEAEEDELVSEVPNPPPKKIRLQEPEDQIDGMDSLSQNGEGKLSVTEDGSSSSKNSNLNVCNVCLGILQDFCEKEFIKKVCQKVEASGFEFTNLVLSVSFPPQLSVREHAAWLLVKQEMGKQSLSLGRNDIVQLKEAYKWITHPLFSEELGVPIDGKSLFEVSVVFAHPETVEDCHFLRAICPDCFKPAKNKQSVFTRMAVMKALNKIKEEDFCKQFPCPPNSPKAVCTVLEIECAHGAVFVAGFNFSSSGREDVDVRTLGNGRPFAIELVNPHRVHFTSQEIKELQQKINNSSNKIQVRDLQLVTREAIGHMKEGEEEKTKTYSALIWTNKAIQRKDIEFLDDIKDLNIDQKTPLRVLHRRPLAVRTRIIHSMETRYVDEHHFRLYLKTQAGTYIKEFVHGDFGRTKPNIGSLMDVTADILELDVESVDVDWPPALDD", "length": 490, "header": "tr|A0ABI0NXF9-1|A0ABI0NXF9_BOVIN Computationally mapped isoform of tRNA pseudouridine synthase Pus10 OS=Bos taurus OX=9913 GN=PUS10 PE=3 SV=1 CANONICAL=F1MRD5-1" }, "locus": { "chromosome": "11", "start_pos": 43755495, "end_pos": 43676537, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000145937.1", "url": "https://www.ensembl.org/id/ENSBTAT00000145937.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000105500.1", "url": "https://www.ensembl.org/id/ENSBTAP00000105500.1" } ] } }, { "isoform_ac": "F1MRD5-1", "url": "https://www.uniprot.org/uniprotkb/F1MRD5/entry", "sequence": { "sequence": "MFPLTVENKHVAQLLLSTGTCPRCIFRFCGVDFHAPYKLPYKELLRELQKFLEAEEDELVSEVPNPPPKKIRLQEPEDQIDGMDSLSQNGEGKLSVTEDGSSSSKNSNLNVCNVCLGILQDFCEKEFIKKVCQKVEASGFEFTNLVLSVSFPPQLSVREHAAWLLVKQEMGELIFMLFRKQSLSLGRNDIVQLKEAYKWITHPLFSEELGVPIDGKSLFEVSVVFAHPETVEDCHFLRAICPDCFKPAKNKQSVFTRMAVMKALNKIKEEDFCKQFPCPPNSPKAVCTVLEIECAHGAVFVAGRYNKYSRNLPQTPWIIDGERKLESSVEELISDHLLKVFKAESFNFSSSGREDVDVRTLGNGRPFAIELVNPHRVHFTSQEIKELQQKINNSSNKIQVRDLQLVTREAIGHMKEGEEEKTKTYSALIWTNKAIQRKDIEFLDDIKDLNIDQKTPLRVLHRRPLAVRTRIIHSMETRYVDEHHFRLYLKTQAGTYIKEFVHGDFGRTKPNIGSLMDVTADILELDVESVDVDWPPALDD", "length": 540, "header": "tr|F1MRD5-1|F1MRD5_BOVIN Isoform 1 of tRNA pseudouridine synthase Pus10 OS=Bos taurus OX=9913 GN=PUS10 PE=3 SV=4 CANONICAL=F1MRD5-1" }, "locus": { "chromosome": "11", "start_pos": 43755495, "end_pos": 43676537, "strand": "+", "evidence": [ { "database": 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"MGKKWRDATEMERGCSDREDSAESRRRSRSASRGRFAESWKRLSSKQGSTKRSGLPSQQTPAQKSWIERAFYKRECVHIIPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDVPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMTQAQEIHLQEKEQEEPEKPTKEKDEEDMELTAMLGRNNGESSRKKDEEEVQSRHRFIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHCMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETLSPTSPTLMPRIRSHSFYSVNMKDKGGIEKLESLFKERSLSLHRATSSHSVAKESKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSMNILGLGEPSFSAPVPSAAPSSSAYATLAPTDRLPSRSTDFEDITSMDTRSFSSDYTHIPECQNPWDTDPPMYHTIERSKSSRYLATTPFLLEEASIVKSHSFMFSPSRSCYANFGVPVKTAEYTSITDCIDTRCVNAPQVIADRTTFLGGLGGKVEESLCCHPEREAELSHPSSDGEENEAKGRRATITMPPQEGDNSDRTLSNNITVPKIERANSYSAEEPSTPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRMSAFHSFESKHN", "length": 1711, "header": "tr|F1MQI6-1|F1MQI6_BOVIN Isoform 1 of Transient receptor potential cation channel subfamily M member 3 OS=Bos taurus OX=9913 GN=TRPM3 PE=3 SV=4 CANONICAL=F1MQI6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S1Q0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S1Q0/entry", "sequence": { "sequence": "MPGPWGTVCFLGIAQVCGFWFSWWNLEGVMNQTDAPRPLNWTIRKLCHAAFLPSVRLLKAQKSWIERAFYKRECVHIIPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDSRLFYSFWGSCQLDPIGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDVPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMTQAQEIHLQEKEQEEPEKPTKEKDEEDMELTAMLGRNNGESSRKKDEEEVQSRHRFIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHCMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAEHPFYSV", "length": 1362, "header": "tr|A0AAA9S1Q0-1|F1MQI6_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily M member 3 OS=Bos taurus OX=9913 GN=TRPM3 PE=3 SV=1 CANONICAL=F1MQI6-1" }, "locus": { "chromosome": "8", "start_pos": 47316905, "end_pos": 46715318, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094834.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094834.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000077234.1", "url": "https://www.ensembl.org/id/ENSBTAP00000077234.1" } ] } }, { "isoform_ac": "A0AAA9SC59-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SC59/entry", "sequence": { "sequence": "MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDSRLFYSFWGSCQLDPIGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDVPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMTQAQEIHLQEKEQEEPEKPTKEKDEEDMELTAMLGRNNGESSRKKDEEEVQSRHRFIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHCMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETLSPTSPTLMPRIRSHSFYSVNMKDKGGIEKLESLFKERSLSLHRATSSHSVAKESKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSMNILGLGEPSFSAPVPSAAPSSSAYATLAPTDRLPSRSTDFEDITSMDTRSFSSDYTHIPECQNPWDTDPPMYHTIERSKSSRYLATTPFLLEEASIVKSHSFMFSPSRSCYANFGVPVKTAEYTSITDCIDTRCVNAPQVIADRTTFLGGLGGKVEESLCCHPEREAELSHPSSDGEENEAKGRRATITMPPQEGDNSDRTLSNNITVPKIERANSYSAEEPSTPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRMSAFHSFESKHN", "length": 1569, "header": "tr|A0AAA9SC59-1|F1MQI6_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily M member 3 OS=Bos taurus OX=9913 GN=TRPM3 PE=3 SV=1 CANONICAL=F1MQI6-1" }, "locus": { "chromosome": "8", "start_pos": 47017431, "end_pos": 46715836, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116853.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116853.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000079816.1", "url": "https://www.ensembl.org/id/ENSBTAP00000079816.1" } ] } }, { "isoform_ac": "A0AAA9SPP2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPP2/entry", "sequence": { "sequence": "MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDSRLFYSFWGSCQLDPIGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDVPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMTQAQEIHLQEKEQEEPEKPTKEKDEEDMELTAMLGRNNGESSRKKDEEEVQSRHRFIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHCMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETLSPTSPTLMPRIRSHSFYSVNMKDKGGIEKLESLFKERSLSLHRATSSHSVAKESKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSMNILGLGEPSFSAPVPSAAPSSSAYATLAPTDRLPSRSTDFEDITSMDTRSFSSDYTHIPECQNPWDTDPPMYHTIERSKSSRYLATTPFLLEEASIVKSHSFMFSPSRSCYANFGVPVKTAEYTSITDCIDTRCVNAPQVIADRTTFLGGLGGKVEESLCCHPEREAELSHPSSDGEENEAKGRRATITMPPQEGDNSDRTLSNNITVPKIERANSYSAEEPSTPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRMSAFHSFESKHN", "length": 1579, "header": "tr|A0AAA9SPP2-1|F1MQI6_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily M member 3 OS=Bos taurus OX=9913 GN=TRPM3 PE=3 SV=1 CANONICAL=F1MQI6-1" }, "locus": { "chromosome": "8", "start_pos": 47017431, "end_pos": 46715836, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101004.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101004.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087330.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087330.1" } ] } }, { "isoform_ac": "A0AAA9TC89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TC89/entry", "sequence": { "sequence": "MYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDVPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMTQAQEIHLQEKEQEEPEKPTKEKDEEDMELTAMLGRNNGESSRKKDEEEVQSRHRFIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHCMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAEDHPHV", "length": 1171, "header": "tr|A0AAA9TC89-1|F1MQI6_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily M member 3 OS=Bos taurus OX=9913 GN=TRPM3 PE=3 SV=1 CANONICAL=F1MQI6-1" }, "locus": { "chromosome": "8", "start_pos": 47017431, "end_pos": 46716759, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095195.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095195.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093721.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093721.1" } ] } }, { "isoform_ac": "A0AAA9U207-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U207/entry", "sequence": { "sequence": "MPGPWGTVCFLGIAQVCGFWFSWWNLEGVMNQTDAPRPLNWTIRKLCHAAFLPSVRLLKAQKSWIERAFYKRECVHIIPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDVPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMTQAQEIHLQEKEQEEPEKPTKEKDEEDMELTAMLGRNNGESSRKKDEEEVQSRHRFIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHCMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETLSPTSPTLMPRIRSHSFYSVNMKDKGGIEKLESLFKERSLSLHRATSSHSVAKESKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSMNILGLGEPSFSAPVPSAAPSSSAYATLAPTDRLPSRSTDFEDITSMDTRSFSSDYTHIPECQNPWDTDPPMYHTIERSKSSRYLATTPFLLEEASIVKSHSFMFSPSRSCYANFGVPVKTAEYTSITDCIDTRCVNAPQVIADRTTFLGGLGGKVEESLCCHPEREAELSHPSSDGEENEAKGRRATITMPPQEGDNSDRTLSNNITVPKIERANSYSAEEPSTPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRMSAFHSFESKHN", "length": 1707, "header": "tr|A0AAA9U207-1|F1MQI6_BOVIN Computationally mapped isoform of Transient receptor potential cation channel subfamily M member 3 OS=Bos taurus OX=9913 GN=TRPM3 PE=3 SV=1 CANONICAL=F1MQI6-1" }, "locus": { "chromosome": "8", "start_pos": 47316905, "end_pos": 46715836, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000095042.1", "url": "https://www.ensembl.org/id/ENSBTAT00000095042.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103960.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103960.1" } ] } }, { "isoform_ac": "F1MQI6-1", "url": "https://www.uniprot.org/uniprotkb/F1MQI6/entry", "sequence": { "sequence": "MGKKWRDATEMERGCSDREDSAESRRRSRSASRGRFAESWKRLSSKQGSTKRSGLPSQQTPAQKSWIERAFYKRECVHIIPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDVPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMTQAQEIHLQEKEQEEPEKPTKEKDEEDMELTAMLGRNNGESSRKKDEEEVQSRHRFIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHCMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETLSPTSPTLMPRIRSHSFYSVNMKDKGGIEKLESLFKERSLSLHRATSSHSVAKESKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSMNILGLGEPSFSAPVPSAAPSSSAYATLAPTDRLPSRSTDFEDITSMDTRSFSSDYTHIPECQNPWDTDPPMYHTIERSKSSRYLATTPFLLEEASIVKSHSFMFSPSRSCYANFGVPVKTAEYTSITDCIDTRCVNAPQVIADRTTFLGGLGGKVEESLCCHPEREAELSHPSSDGEENEAKGRRATITMPPQEGDNSDRTLSNNITVPKIERANSYSAEEPSTPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRMSAFHSFESKHN", "length": 1711, "header": "tr|F1MQI6-1|F1MQI6_BOVIN Isoform 1 of Transient receptor potential cation channel subfamily M member 3 OS=Bos taurus OX=9913 GN=TRPM3 PE=3 SV=4 CANONICAL=F1MQI6-1" }, "locus": { "chromosome": "8", "start_pos": 47665989, "end_pos": 46715836, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061517.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061517.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053318.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053318.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:540699", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:540699", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium channel activity", "id": "GO:0005262", "url": 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"MEAAAGAGRGAPPGPPRAAAVPCFGISVDQDDILPGALRLIRELRPRWKPERVRTKRFTDGITNKLVACYVEEDMRDCVLVRVYGERTELLVDRESEVRNFQLLRAHGCAPKLYCTFQNGLCYEYMRGVALGPEHIREPRLFRLIALEMAKIHTIHANGSLPKPTLWHKIHNYFALVKNEINPSLSADVPEVGVLERELVWLKEHLPPLDSPVVFCHNDLLCKNIIYDSSKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYSRYPARETQLLWLRYYLQAQNGTAVTPREVERLYVQVNKFALASHFLWALWALIQNQFSTIDFDFLRYAVIRFNQYFKVKPQVAALEMPK", "length": 356, "header": "tr|F1MRD9-1|F1MRD9_BOVIN Isoform 1 of ethanolamine kinase OS=Bos taurus OX=9913 GN=ETNK2 PE=3 SV=3 CANONICAL=F1MRD9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S2U2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2U2/entry", "sequence": { "sequence": "MEAAAGAGRGAPPGPPRAAAVPCFGISVDQDDILPGALRLIRELRPRWKPERVRTKRFTDGITNKLVACYVEEDMRDCVLVRVYGERTELLVDRESEVRNFQLLRAHGCAPKLYCTFQNGLCYEYMRGVALGPEHIREPRLFRLIALEMAKIHTIHANGSLPKPTLWHKIHNYFALVKNEINPSLSADVPEVGVLERELVWLKEHLPPLDSPVVFCHNDLLCKNIIYDSSKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYSRYPARETQLLWLRYYLQAQNGTAVTPREVERLYVQVNKFALASHFLWALWALIQNQFSTIDFDFLSPPEEGCCCLDACRVHVPRTPL", "length": 354, "header": "tr|A0AAA9S2U2-1|F1MRD9_BOVIN Computationally mapped isoform of ethanolamine kinase OS=Bos taurus OX=9913 GN=ETNK2 PE=3 SV=1 CANONICAL=F1MRD9-1" }, "locus": { "chromosome": "16", "start_pos": 1934210, "end_pos": 1918880, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108491.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108491.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000076424.1", "url": "https://www.ensembl.org/id/ENSBTAP00000076424.1" } ] } }, { "isoform_ac": "F1MRD9-1", "url": "https://www.uniprot.org/uniprotkb/F1MRD9/entry", "sequence": { "sequence": "MEAAAGAGRGAPPGPPRAAAVPCFGISVDQDDILPGALRLIRELRPRWKPERVRTKRFTDGITNKLVACYVEEDMRDCVLVRVYGERTELLVDRESEVRNFQLLRAHGCAPKLYCTFQNGLCYEYMRGVALGPEHIREPRLFRLIALEMAKIHTIHANGSLPKPTLWHKIHNYFALVKNEINPSLSADVPEVGVLERELVWLKEHLPPLDSPVVFCHNDLLCKNIIYDSSKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYSRYPARETQLLWLRYYLQAQNGTAVTPREVERLYVQVNKFALASHFLWALWALIQNQFSTIDFDFLRYAVIRFNQYFKVKPQVAALEMPK", "length": 356, "header": "tr|F1MRD9-1|F1MRD9_BOVIN Isoform 1 of ethanolamine kinase OS=Bos taurus OX=9913 GN=ETNK2 PE=3 SV=3 CANONICAL=F1MRD9-1" }, "locus": { "chromosome": "16", "start_pos": 1934210, "end_pos": 1917436, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024637.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024637.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024637.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024637.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 292, "start_aa": "Thr", "end_pos": 292, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr292", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:533229", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:533229", "resource": "KEGG Pathway" }, { "id": "R-BTA-1483213", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483213", "resource": "Reactome", "description": "Synthesis of PE" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2Q783-1", "protein_name": "ethanolamine kinase", "gene_name": "ETNK2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGHGGEGGGRRGLPGAAGPPRAAAVPCFGISVDHNDILPGALRLIRELRPHWKPEQVRTKRFTDGITNKLVACYVDEDMRDCVLVRVYGERTELLVDRENEVRNFQLLRAHGCAPKLYCTFQNGLCYEYMQGMALGPEHIREPRLFRLIALEMAKIHTIHANGSLPKPILWHKIHNYFTLVKNEINPSLSADVPKVEVLEQELAWLKEHLSQLDSPVVFCHNDLLCKNIIYDSTKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYCLYPSRETQLQWLRYYLQAQKGMAVTPREVERLYVQVNKFALASHFLWALWALIQSQFSTIDFDFLRYAVIRFNQYFKVKPQVSALEMPK", "length": 360 }, "evidence": [ { "id": "F1MRD9", "url": "https://omabrowser.org/oma/group/F1MRD9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A7MCT6-1", "protein_name": "Ethanolamine kinase 2", "gene_name": "Etnk2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAVPPSAPVPCSPFYLRRQEPCPQCSWSMEEKAVASAGCWEPPGPPRAAVPCFSVTVEQDDILPGALRLIRELRPHWKPEQVRTKRFKDGITNKLLACYVEEDMRDCVLVRVYGERTELLVDRENEVRNFQLLRAHGCAPKLYCTFQNGLCYEYVQGVALGPEHIREPQLFRLIALEMAKIHTIHANGSLPKPTLWHKMHRYFTLVKDEISPSLSADVPKVEVLEQELAWLKEHLSQLDSPVVFCHNDLLCKNIIYDSDKGRVCFIDYEYAGYNYQAFDIGNHFNEFAGVNVVDYSRYPARETQVQWLRYYLEAQKGTAASPREVERLYAQVNKFALASHFFWALWALIQNQYSTISFDFLRYAVIRFNQYFKVKPQVSALEMPK", "length": 385 }, "evidence": [ { "id": "F1MRD9", "url": "https://omabrowser.org/oma/group/F1MRD9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1NL82-1", "protein_name": "ethanolamine kinase", "gene_name": "ETNK2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MGRGSGRSEPGMAVPPGRCPDCWETERGGGGGGSRGVPGVLQLGVLVDEGDVLPGALRLMRELRPSWEPARVKTKLFTDGITNKLVACYTDEDMADAVLVRVYGRKTELFVDRETELRNFQVLRAHGCAPDLYCAFQNGLCYEFLPGIALGPDHVRDPRIFRLVAQEMARVHAIHANGSLPKPILWQKLHKYLALVKMDLSPKVPNPSLHQDVPSLEMLEHELAWMKDTLSQLGSPVVLCHNDLLCKNIIYNRAQEHVRFIDYEYTGYNYQAFDIGNHFNEFAGVKEVDYRLYPSKETQLQWLRSYLQAYKQLTQGGQGGTGVTVSEKELEALYVQVNKFSLASHFLWACWGLIQDKYSTIDFNFLRYAKLRFRQYFKMKPVVTALQISK", "length": 390 }, "evidence": [ { "id": "F1MRD9", "url": "https://omabrowser.org/oma/group/F1MRD9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O81024-1", "protein_name": "Probable ethanolamine kinase", "gene_name": "EMB1187", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MGAAKNIWALANAEDAANDAEQIPYSSFVVDTSLPLPLMIPRIIELCKDLFKNWGELDDSLFSVERVSGGITNLLLKVSVKEDTNKEVSVTVRLYGPNTEYVINREREILAIKYLSAAGFGAKLLGGFGNGMVQSFINARTLEPSDMREPKIAAQIARELGKFHKVDIPGSKEPQLWVDILKFYEKASTLTFEEPDKQKLFETISFEELHKEIIELREFTGLLNAPVVFAHNDLLSGNFMLNDEEEKLYLIDFEYGSYNYRGFDIGNHFNEYAGYDCDYSLYPSKEEQYHFIKHYLQPDKPDEVSIAEVESVFVETDAYKLASHLYWAIWAIIQARMSPIEFEYLGYFFLRYNEYKKQKPLTFSLVTSHLSASL", "length": 374 }, "evidence": [ { "id": "F1MRD9", "url": "https://omabrowser.org/oma/group/F1MRD9/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9NVF9-1", "protein_name": "Ethanolamine kinase 2", "gene_name": "ETNK2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAVPPSAPQPRASFHLRRHTPCPQCSWGMEEKAAASASCREPPGPPRAAAVAYFGISVDPDDILPGALRLIQELRPHWKPEQVRTKRFTDGITNKLVACYVEEDMQDCVLVRVYGERTELLVDRENEVRNFQLLRAHSCAPKLYCTFQNGLCYEYMQGVALEPEHIREPRLFRLIALEMAKIHTIHANGSLPKPILWHKMHNYFTLVKNEINPSLSADVPKVEVLERELAWLKEHLSQLESPVVFCHNDLLCKNIIYDSIKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYCLYPARETQLQWLHYYLQAQKGMAVTPREVQRLYVQVNKFALASHFFWALWALIQNQYSTIDFDFLRYAVIRFNQYFKVKPQASALEMPK", "length": 386 }, "evidence": [ { "id": "F1MRD9", "url": "https://omabrowser.org/oma/group/F1MRD9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MRD9", "url": "https://www.uniprot.org/uniprotkb/F1MRD9" } ], "pmid": "" }, { "name": "ethanolamine kinase activity", "id": "GO:0004305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004305", "evidence": [ { "database": "UniProtKB", "id": "F1MRD9", "url": "https://www.uniprot.org/uniprotkb/F1MRD9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "phospholipid biosynthetic process", "id": "GO:0008654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008654", "evidence": [ { "database": "UniProtKB", "id": "F1MRD9", "url": "https://www.uniprot.org/uniprotkb/F1MRD9" } ], "pmid": "" }, { "name": "phosphatidylethanolamine biosynthetic process", "id": "GO:0006646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006646", "evidence": [ { "database": "UniProtKB", "id": "F1MRD9", "url": "https://www.uniprot.org/uniprotkb/F1MRD9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MRD9", "url": "https://www.uniprot.org/uniprotkb/F1MRD9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 158, "end_pos": 160, "annotation": "n_glycosylation_sequon" }, { "start_pos": 287, "end_pos": 289, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-1498751" ], "output_participant_list": [], "enzyme_list": [ "G3X782-1", "F1N378-1", "A0A3Q1LRY5-1", "F1MRD9-1" ], "evidence": [ { "id": "R-BTA-1483222", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1483222" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1498751", "participant_name": "ETA [cytosol]", "crossref": [ { "id": "57603", "database": "ChEBI", "url": "" }, { "id": "ZINC000008214617", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LRY5", "gene_name": "CHKA", "activity": [ { "ec_number": "2.7.1.32", "activity": "choline + ATP = phosphocholine + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ] }, { "ec_number": "2.7.1.82", "activity": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "A0A3Q1LRY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRY5" } ] } ] }, { "uniprot_ac": "F1MRD9", "gene_name": "ETNK2", "activity": [ { "ec_number": "2.7.1.82", "activity": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+).", "evidence": [ { "id": "F1MRD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRD9" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "F1MRD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRD9" } ] } ] }, { "uniprot_ac": "F1N378", "gene_name": "ETNK1", "activity": [ { "ec_number": "2.7.1.82", "activity": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+).", "evidence": [ { "id": "F1N378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N378" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "F1N378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N378" } ] } ] }, { "uniprot_ac": "G3X782", "gene_name": "CHKB", "activity": [ { "ec_number": "2.7.1.32", "activity": "choline + ATP = phosphocholine + ADP + H(+).", "evidence": [ { "id": "G3X782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X782" } ] }, { "ec_number": "2.7.1.82", "activity": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+).", "evidence": [ { "id": "G3X782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X782" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "G3X782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X782" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "G3X782", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3X782" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MRD9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 356, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MRD9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MRD9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.1.82", "ec_name": "ethanolamine + ATP = phosphoethanolamine + ADP + H(+).", "evidence": [ { "id": "2.7.1.82", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82" }, { "id": "2.7.1.82", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.82" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 292 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 158, "end_pos": 160 }, { "start_pos": 287, "end_pos": 289 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"uniprot_ac": "F1MS41", "uniprot_id": "F1MS41_BOVIN", "mass": { "chemical_mass": 23639.0, "monoisotopic_mass": 23639.0 }, "refseq": {}, "gene_names": [ { "name": "SNCB", "type": "recommended", "evidence": [ { "id": "F1MS41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS41" } ] } ], "protein_names": [ { "name": "Beta-synuclein", "type": "recommended", "evidence": [ { "id": "F1MS41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS41/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MS41", "url": "https://www.uniprot.org/uniprotkb/F1MS41" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNCB", "url": "https://www.uniprot.org/uniprotkb/F1MS41", "locus": { "chromosome": "7", "start_pos": 38091557, "end_pos": 38100517, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009803", "url": "https://www.ensembl.org/id/ENSBTAG00000009803" } ] } } ], "crossref": [ { "id": "F1MS41", "url": "https://alphafold.ebi.ac.uk/entry/F1MS41", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009803", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009803", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002461", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002461", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MS41", "url": "https://www.orthodb.org/?gene=F1MS41", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13820", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13820", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13820:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13820:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01387", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01387", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S402", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S402", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S402-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S402-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5C6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5C6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS41", "url": "https://www.uniprot.org/uniprotkb/F1MS41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MS41-1", "url": "https://www.uniprot.org/uniprotkb/F1MS41-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "SSELPQRPSRSRSARDSRALEASGGWRSTPGPDTTAPRLRARASSAANQPERLDTARSLIGPSPPRPSPAEPVRPPAAASAAAATPSPTRAPHLGRQDGSVHEGPVHGQGGRRGRRGENQAGGHRGRGEDQGGKTREGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKKEEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEEQPQEEYQEYEPEA", "length": 225, "header": "tr|F1MS41-1|F1MS41_BOVIN Isoform 1 of Beta-synuclein OS=Bos taurus OX=9913 GN=SNCB PE=3 SV=3 CANONICAL=F1MS41-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S402-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S402/entry", "sequence": { "sequence": "MEVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVVAEKTKEQASHLGGAVFSGAGNIAAATGLVKKEEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEEQPQEEYQEYEPEA", "length": 120, "header": "tr|A0AAA9S402-1|F1MS41_BOVIN Computationally mapped isoform of Beta-synuclein OS=Bos taurus OX=9913 GN=SNCB PE=3 SV=1 CANONICAL=F1MS41-1" }, "locus": { "chromosome": "7", "start_pos": 38099589, "end_pos": 38092174, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098915.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098915.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078005.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078005.1" } ] } }, { "isoform_ac": "A0AAA9T5C6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C6/entry", "sequence": { "sequence": "SSELPQRPSRSRSARDSRALEASGGWRSTPGPDTTAPRLRARASSAANQPERLDTARSLIGPSPPRPSPAEPVRPPAAASAAAATPSPTRAPHLGSKTREGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKKEEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEEQPQEEYQEYEPEA", "length": 188, "header": "tr|A0AAA9T5C6-1|F1MS41_BOVIN Computationally mapped isoform of Beta-synuclein OS=Bos taurus OX=9913 GN=SNCB PE=3 SV=1 CANONICAL=F1MS41-1" }, "locus": { "chromosome": "7", "start_pos": 38100516, "end_pos": 38092174, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120025.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120025.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090936.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090936.1" } ] } }, { "isoform_ac": "F1MS41-1", "url": "https://www.uniprot.org/uniprotkb/F1MS41/entry", "sequence": { "sequence": "SSELPQRPSRSRSARDSRALEASGGWRSTPGPDTTAPRLRARASSAANQPERLDTARSLIGPSPPRPSPAEPVRPPAAASAAAATPSPTRAPHLGRQDGSVHEGPVHGQGGRRGRRGENQAGGHRGRGEDQGGKTREGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKKEEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEEQPQEEYQEYEPEA", "length": 225, "header": "tr|F1MS41-1|F1MS41_BOVIN Isoform 1 of Beta-synuclein OS=Bos taurus OX=9913 GN=SNCB PE=3 SV=3 CANONICAL=F1MS41-1" }, "locus": { "chromosome": "7", "start_pos": 38100516, "end_pos": 38092174, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012928.7", "url": "https://www.ensembl.org/id/ENSBTAT00000012928.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012928.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012928.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 85, "start_aa": "Thr", "end_pos": 85, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr85", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MS41", "url": "https://www.uniprot.org/uniprotkb/F1MS41" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "F1MS41", "url": "https://www.uniprot.org/uniprotkb/F1MS41" } ], "pmid": "" }, { "name": "axon terminus", "id": "GO:0043679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043679", "evidence": [ { "database": "UniProtKB", "id": "F1MS41", "url": "https://www.uniprot.org/uniprotkb/F1MS41" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "synapse organization", "id": "GO:0050808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050808", "evidence": [ { "database": "UniProtKB", "id": "F1MS41", "url": "https://www.uniprot.org/uniprotkb/F1MS41" } ], "pmid": "" }, { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "F1MS41", "url": "https://www.uniprot.org/uniprotkb/F1MS41" } ], "pmid": "" }, { "name": "synaptic vesicle endocytosis", "id": "GO:0048488", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048488", "evidence": [ { "database": "UniProtKB", "id": "F1MS41", "url": "https://www.uniprot.org/uniprotkb/F1MS41" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cuprous ion binding", "id": "GO:1903136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903136", "evidence": [ { "database": "UniProtKB", "id": "F1MS41", "url": "https://www.uniprot.org/uniprotkb/F1MS41" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MS41-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 225, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MS41-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MS41" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 85 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MT98-1", "uniprot_ac": "F1MT98", "uniprot_id": "F1MT98_BOVIN", "mass": { "chemical_mass": 46168.0, "monoisotopic_mass": 46168.0 }, "refseq": { "ac": "NP_001178165", "name": "ETS domain-containing protein Elk-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178165" }, "gene_names": [ { "name": "ELK1", "type": "recommended", "evidence": [ { "id": "F1MT98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ] }, { "name": "ELK1", "type": "synonym", "evidence": [ { "id": "NP_001178165", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178165" } ] } ], "protein_names": [ { "name": "ETS domain-containing protein Elk-1", "type": "recommended", "evidence": [ { "id": "F1MT98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT98/entry#names_and_taxonomy" } ] }, { "name": "ELK1, ETS transcription factor", "type": "synonym", "evidence": [ { "id": "NP_001178165", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178165" } ] }, { "name": "ETS domain-containing protein Elk-1", "type": "synonym", "evidence": [ { "id": "NP_001178165", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178165" } ] } ], "function": [ { "annotation": "Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation.", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98#function" }, { "database": "UniProtKB", "id": "ARBA00055801", "url": "https://www.uniprot.org/uniprotkb/ARBA00055801#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ELK1", "url": "https://www.uniprot.org/uniprotkb/F1MT98", "locus": { "chromosome": "X", "start_pos": 86007731, "end_pos": 86022472, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015817", "url": "https://www.ensembl.org/id/ENSBTAG00000015817" } ] } } ], "crossref": [ { "id": "F1MT98", "url": "https://alphafold.ebi.ac.uk/entry/F1MT98", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000015817", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000015817", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "786886", "url": "https://www.ncbi.nlm.nih.gov/gene/786886", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046328", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046328", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:786886", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786886", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LPSRYPW", "url": "https://omabrowser.org/oma/group/LPSRYPW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MT98", "url": "https://www.orthodb.org/?gene=F1MT98", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11849:SF178", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11849:SF178", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00178", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00178", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178165", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9S7N4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S7N4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MT98-1", "url": "https://www.uniprot.org/uniprotkb/F1MT98-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTLANAGATAVHAIPGDTASGKPGTLKGAGMAGPGGLARSSRNDYMRSGLYSTFTIQSLQPQPPSHPRPSTVLPNTGPAGVAVPPSGSRSTSPNPLEACLEAEEAGLPLQVILTPPEAPNLKSEEPNMEPGLGRPLPPEVKVEEPKEELEAAASGEAGFVLEAVKAEPFEPKVDPEVPPAEGVPARLSAVAMETAAQAGSLTASTTPSTEIAQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGTGSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP", "length": 440, "header": "tr|F1MT98-1|F1MT98_BOVIN Isoform 1 of ETS domain-containing protein Elk-1 OS=Bos taurus OX=9913 GN=ELK1 PE=3 SV=2 CANONICAL=F1MT98-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S7N4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S7N4/entry", "sequence": { "sequence": "MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPESHCTP", "length": 95, "header": "tr|A0AAA9S7N4-1|F1MT98_BOVIN Computationally mapped isoform of ETS domain-containing protein Elk-1 OS=Bos taurus OX=9913 GN=ELK1 PE=3 SV=1 CANONICAL=F1MT98-1" }, "locus": { "chromosome": "X", "start_pos": 86013487, "end_pos": 86008588, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126727.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126727.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078166.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078166.1" } ] } }, { "isoform_ac": "F1MT98-1", "url": "https://www.uniprot.org/uniprotkb/F1MT98/entry", "sequence": { "sequence": "MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTLANAGATAVHAIPGDTASGKPGTLKGAGMAGPGGLARSSRNDYMRSGLYSTFTIQSLQPQPPSHPRPSTVLPNTGPAGVAVPPSGSRSTSPNPLEACLEAEEAGLPLQVILTPPEAPNLKSEEPNMEPGLGRPLPPEVKVEEPKEELEAAASGEAGFVLEAVKAEPFEPKVDPEVPPAEGVPARLSAVAMETAAQAGSLTASTTPSTEIAQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGTGSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP", "length": 440, "header": "tr|F1MT98-1|F1MT98_BOVIN Isoform 1 of ETS domain-containing protein Elk-1 OS=Bos taurus OX=9913 GN=ELK1 PE=3 SV=2 CANONICAL=F1MT98-1" }, "locus": { "chromosome": "X", "start_pos": 86013487, "end_pos": 86008383, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021012.6", "url": "https://www.ensembl.org/id/ENSBTAT00000021012.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021012.5", "url": "https://www.ensembl.org/id/ENSBTAP00000021012.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:786886", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786886", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A4GTP4-1", "protein_name": "ETS domain-containing protein Elk-1", "gene_name": "Elk1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSAVAMAPATVHSGPGDNATGKPGTPKGAGMTGQGGLARSSRNEYMRSGLYSTFTIQSLQPQPPLHPRPASVLPNTTPAGVPAPPSGSRSTSPNPLEACLEAEEAGLPLQVILTPPEAPNQKSEELSLNPGFGRPQPPEVKVEGPKEELEVTEVGGFSPEAVKAEQEVSPSEGLLARLPAILTENTAQVCGLSTSTTEITQPQKGRKPRDLELPLSPSLLGGQGPERTPGSGTSSGLQAQGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP", "length": 427 }, "evidence": [ { "id": "F1MT98", "url": "https://omabrowser.org/oma/group/F1MT98/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3HXI9-1", "protein_name": "ETS domain-containing protein Elk-1", "gene_name": "Elk1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPSQPEVSVASTVAMAPAAVHAAPGDTATGKPGTPKGAGMAGQSGLARSSRNEYMRSGLYSTFTIQSLQPQPPLHPRPASVLPNTTPAGVQAPPSGSRSTSPNPLEACLEAEEAGLPLQVILTPPEAPNQKSEELSLEPGFGRPLPPEVKVEGPREELEAVGAACFGSETVKAEPEVSPSEGLLARLPAVLMENTAQVCGLSASATEITQPQKGRKPRDLELPLSPSLLGGPGPERTPGTGSGLQPPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP", "length": 425 }, "evidence": [ { "id": "F1MT98", "url": "https://omabrowser.org/oma/group/F1MT98/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P19419-1", "protein_name": "ETS domain-containing protein Elk-1", "gene_name": "ELK1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIHAAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPPPHPRPAVVLPSAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQVILTPPEAPNLKSEELNVEPGLGRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEVPPQEGVPARLPAVVMDTAGQAGGHAASSPEISQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGSGSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP", "length": 428 }, "evidence": [ { "id": "F1MT98", "url": "https://omabrowser.org/oma/group/F1MT98/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P41969-1", "protein_name": "ETS domain-containing protein Elk-1", "gene_name": "Elk1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSAIAMAPATVHAGPGDTATGKPGTPKGAGMTGQGGLARSSRNEYMRSGLYSTFTIQSLQPQPQPPIPPRPASVLPNTTPAGVPAPASGSRSTSPNPLEACLEAEEAGLPLQVILTPPEAPNQKSEELSLDPSFGHPQPPEVKVEGPKEELEAARAGGFSSEAVKAEPEVSASEGLLARLPAILTENTAQVCGLSTSTTEITQPQKGRKPRDLELPLSPSLLGGQGPERTPGSGTSSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP", "length": 429 }, "evidence": [ { "id": "F1MT98", "url": "https://omabrowser.org/oma/group/F1MT98/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "DNA-binding transcription factor activity", "id": "GO:0003700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "pmid": "" }, { "name": "mediator complex binding", "id": "GO:0036033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036033", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "pmid": "" }, { "name": "transcription regulator inhibitor activity", "id": "GO:0140416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140416", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "pmid": "" }, { "name": "transcription regulator activator activity", "id": "GO:0140537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140537", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MT98", "url": "https://www.uniprot.org/uniprotkb/F1MT98" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 51, "end_pos": 53, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MT98-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 440, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MT98-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MT98" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MT98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT98" }, { "id": "PS50061", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50061" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "ETS", "eco_id": "ECO_0000259", "start_pos": 5, "end_pos": 86, "start_aa": "Val", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 51, "end_pos": 53 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1ML71-1", "uniprot_ac": "F1ML71", "uniprot_id": "F1ML71_BOVIN", "mass": { "chemical_mass": 40630.0, "monoisotopic_mass": 40630.0 }, "refseq": {}, "gene_names": [ { "name": "NDFIP2", "type": "recommended", "evidence": [ { "id": "F1ML71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML71" } ] } ], "protein_names": [ { "name": "Nedd4 family interacting protein 2", "type": "synonym", "evidence": [ { "id": "F1ML71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML71/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1ML71", "url": "https://www.uniprot.org/uniprotkb/F1ML71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "NDFIP2", "url": "https://www.uniprot.org/uniprotkb/F1ML71", "locus": { "chromosome": "12", "start_pos": 54649183, "end_pos": 54578346, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014227", "url": "https://www.ensembl.org/id/ENSBTAG00000014227" } ] } } ], "crossref": [ { "id": "F1ML71", "url": "https://alphafold.ebi.ac.uk/entry/F1ML71", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000014227", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014227", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22306", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22306", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR019325", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019325", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1ML71", "url": "https://www.orthodb.org/?gene=F1ML71", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13396", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13396", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13396:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13396:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF10176", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10176", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9S9F3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9S9F3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRK7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRK7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML71", "url": "https://www.uniprot.org/uniprotkb/F1ML71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML71-1", "url": "https://www.uniprot.org/uniprotkb/F1ML71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRLFYPRQRDSACKQPFGLKRPIKDAKPPLATRMGRRRTQRACATIPSMLSSAHGAPELRPQAAADAEVSAASAAATGSEAARPGDRGRRNRGGRVAEATTSLKGVAEGAECRGDSPTRKPDPEPGRMDHHQAGTGRYQVLHNEEDNSESSAVEQPSTSNPTPHTVQAAPSASGHETESSPPPYSSITVEVPTTSDTEVYSEFYPVPPPYSVATSLPTYDEAEKAKAAALAAAAAETSQRIQEEECPPRDDFNDPDQLRVGNDGIFMLAFFMAFIFNWLGFCLSFCITNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSESMAAAHRTRYFFLL", "length": 369, "header": "tr|F1ML71-1|F1ML71_BOVIN Isoform 1 of Nedd4 family interacting protein 2 OS=Bos taurus OX=9913 GN=NDFIP2 PE=4 SV=2 CANONICAL=F1ML71-1" }, "isoforms": [ { "isoform_ac": "A0AAA9S9F3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9F3/entry", "sequence": { "sequence": "MDHHQAGTGRYQVIQEEECPPRDDFNDPDQLRVGNDGIFMLAFFMAFIFNWLGFCLSFCITNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSESMAAAHRTRYFFLL", "length": 142, "header": "tr|A0AAA9S9F3-1|F1ML71_BOVIN Computationally mapped isoform of Nedd4 family interacting protein 2 OS=Bos taurus OX=9913 GN=NDFIP2 PE=4 SV=1 CANONICAL=F1ML71-1" }, "locus": { "chromosome": "12", "start_pos": 54644949, "end_pos": 54578965, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000127346.2", "url": "https://www.ensembl.org/id/ENSBTAT00000127346.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000078761.1", "url": "https://www.ensembl.org/id/ENSBTAP00000078761.1" } ] } }, { "isoform_ac": "A0AAA9SRK7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRK7/entry", "sequence": { "sequence": "MGRRRTQRACATIPSMLSSAHGAPELRPQAAADAEVSAASAAATGSEAARPGDRGRRNRGGRVAEATTSLKGVAEGAECRGDSPTRKPDPEPGRMDHHQAGTGRYQVLHNEEDNSESSAVEQPSTSNPTPHTVQAAPSASGHETESSPPPYSSITVEVPTTSDTEVYSEFYPVPPPYSVATSLPTYDEAEKAKAAALAAAAAETSQRIQEEECPPRDDFNDPDQLRVGNDGIFMLAFFSLLLFFRGFVNYLKVRNMSESMAAAHRTRYFFLL", "length": 272, "header": "tr|A0AAA9SRK7-1|F1ML71_BOVIN Computationally mapped isoform of Nedd4 family interacting protein 2 OS=Bos taurus OX=9913 GN=NDFIP2 PE=4 SV=1 CANONICAL=F1ML71-1" }, "locus": { "chromosome": "12", "start_pos": 54644949, "end_pos": 54578683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000090416.1", "url": "https://www.ensembl.org/id/ENSBTAT00000090416.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089011.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089011.1" } ] } }, { "isoform_ac": "F1ML71-1", "url": "https://www.uniprot.org/uniprotkb/F1ML71/entry", "sequence": { "sequence": "MRLFYPRQRDSACKQPFGLKRPIKDAKPPLATRMGRRRTQRACATIPSMLSSAHGAPELRPQAAADAEVSAASAAATGSEAARPGDRGRRNRGGRVAEATTSLKGVAEGAECRGDSPTRKPDPEPGRMDHHQAGTGRYQVLHNEEDNSESSAVEQPSTSNPTPHTVQAAPSASGHETESSPPPYSSITVEVPTTSDTEVYSEFYPVPPPYSVATSLPTYDEAEKAKAAALAAAAAETSQRIQEEECPPRDDFNDPDQLRVGNDGIFMLAFFMAFIFNWLGFCLSFCITNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSESMAAAHRTRYFFLL", "length": 369, "header": "tr|F1ML71-1|F1ML71_BOVIN Isoform 1 of Nedd4 family interacting protein 2 OS=Bos taurus OX=9913 GN=NDFIP2 PE=4 SV=2 CANONICAL=F1ML71-1" }, "locus": { "chromosome": "12", "start_pos": 54644949, "end_pos": 54578466, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018911.5", "url": "https://www.ensembl.org/id/ENSBTAT00000018911.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018911.3", "url": "https://www.ensembl.org/id/ENSBTAP00000018911.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "vacuolar transport", "id": "GO:0007034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007034", "evidence": [ { "database": "UniProtKB", "id": "F1ML71", "url": "https://www.uniprot.org/uniprotkb/F1ML71" } ], "pmid": "" }, { "name": "metal ion transport", "id": "GO:0030001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030001", "evidence": [ { "database": "UniProtKB", "id": "F1ML71", "url": "https://www.uniprot.org/uniprotkb/F1ML71" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "F1ML71", "url": "https://www.uniprot.org/uniprotkb/F1ML71" } ], "pmid": "" }, { "name": "positive regulation of protein ubiquitination", "id": "GO:0031398", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031398", "evidence": [ { "database": "UniProtKB", "id": "F1ML71", "url": "https://www.uniprot.org/uniprotkb/F1ML71" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "F1ML71", "url": "https://www.uniprot.org/uniprotkb/F1ML71" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1ML71", "url": "https://www.uniprot.org/uniprotkb/F1ML71" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1ML71", "url": "https://www.uniprot.org/uniprotkb/F1ML71" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1ML71", "url": "https://www.uniprot.org/uniprotkb/F1ML71" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "F1ML71", "url": "https://www.uniprot.org/uniprotkb/F1ML71" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1ML71", "url": "https://www.uniprot.org/uniprotkb/F1ML71" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1ML71", "url": "https://www.uniprot.org/uniprotkb/F1ML71" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "WW domain binding", "id": "GO:0050699", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050699", "evidence": [ { "database": "UniProtKB", "id": "F1ML71", "url": "https://www.uniprot.org/uniprotkb/F1ML71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1ML71-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 369, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1ML71-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ML71" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 352, "end_pos": 354 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MT32-1", "uniprot_ac": "F1MT32", "uniprot_id": "F1MT32_BOVIN", "mass": { "chemical_mass": 62835.0, "monoisotopic_mass": 62835.0 }, "refseq": {}, "gene_names": [ { "name": "CERKL", "type": "recommended", "evidence": [ { "id": "F1MT32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT32" } ] } ], "protein_names": [ { "name": "Ceramide kinase like", "type": "synonym", "evidence": [ { "id": "F1MT32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT32/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MT32", "url": "https://www.uniprot.org/uniprotkb/F1MT32" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CERKL", "url": "https://www.uniprot.org/uniprotkb/F1MT32", "locus": { "chromosome": "2", "start_pos": 15084369, "end_pos": 14945219, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009257", "url": "https://www.ensembl.org/id/ENSBTAG00000009257" } ] } } ], "crossref": [ { "id": "F1MT32", "url": "https://alphafold.ebi.ac.uk/entry/F1MT32", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009257", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009257", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100337174", "url": "https://www.ncbi.nlm.nih.gov/gene/100337174", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001206", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001206", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045363", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045363", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:100337174", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100337174", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CYLWYRS", "url": "https://omabrowser.org/oma/group/CYLWYRS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12358", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12358", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12358:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12358:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00781", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00781", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF19280", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19280", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF25382", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF25382", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SAY0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SAY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKT3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SKT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEF4", "url": "https://www.uniprot.org/uniprotkb/F1MEF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MEF4-1", "url": "https://www.uniprot.org/uniprotkb/F1MEF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MT32", "url": "https://www.uniprot.org/uniprotkb/F1MT32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MT32-1", "url": "https://www.uniprot.org/uniprotkb/F1MT32-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPRRRRGGRVSALEGGREEEAPPAAGAVPSAQWASGRQPEAAAELILLRGIFEIGRDSCDVVLSERALRWQPIRPERLTGDSKYDFLHKEEFVELKDIFSVKLKRRYSIKQQGSGTLLGITLFICLKTEKNKLKDSTLDLINLSEDHCDIWFRQFKKILAGFSNRPKSLKILLNPQSHKKEATQVYYEKVEPLLKIAGIKTDVTITEYEGHALSLLKECELQGFDGVVCVGGDGSASEVAHALLLRAQKNAGLETDSILTPVGAQLPLGVIPAGSTNVLAHSLHGVSHVVTATLHIIMGHIQPVDVCTFSTIGKFLRFGFSAMFGFGGRALAVAENHRWMSPNQRMDFAIMKALAKLKPEECEISFLPFNSSQDLEERRAQGYPKSDCNNQWQMIQGQFLNVSIMAIPCQCSVAPRGLAPNTRLNNGSMALITARNTSRPEFIKHLKRYASIKNQFNFPFVDTYTVEEVKVCPKSNSSGHHPEEDHGPHETASGNCFPWNVDGDLMQVASEVHVRVHPRLINLYGRSMEEMNDSKDRLVLSFEEASLKITLYDHCCIVMNILNV", "length": 564, "header": "tr|F1MT32-1|F1MT32_BOVIN Isoform 1 of Ceramide kinase like OS=Bos taurus OX=9913 GN=CERKL PE=4 SV=3 CANONICAL=F1MT32-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SAY0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SAY0/entry", "sequence": { "sequence": "MPRRRRGGRVSALEGGREEEAPPAAGAVPSAQWASGRQPEAAAELILLRGIFEIGRDSCDVVLSERALRWQPIRPERLTGDSKYDFLHKEEFVELKDIFSVKLKRRYSIKQQGSGTLLGITLFICLKTEKNKLKDSTLDLINLSEDHCDIWFRQFKKILAGFSNRPKSLKILLNPQSHKKEATQVYYEKVEPLLKIAGIKTDVTITEYEGHALSLLKECELQGFDGVVCVGGDGSASEVAHALLLRAQKNAGLETDSILTPVGAQLPLGVIPAGSTNVLAHSLHGVSHVVTATLHIIMGHIQPVDVCTFSTIGKFLRFGFSAMFGFGGRALAVAENHRWMSPNQRMDFAIMKALAKLKPEECEISFLPFNSSQDLEERRAQGYPKSDCNNQWQMIQGQFLNVSIMAIPCQCSVAPRGLAPNTRLNNGSMALITARNTSRPEFIKHLKRYASIKNQFNFPFVDTYTVEEVKVCPKSNSSGHHPEEDHGPHETASGNCFPWNVDGDLMQVASEVHVRVHPRLINLYGRSMEEMNDSKVTCSCL", "length": 541, "header": "tr|A0AAA9SAY0-1|F1MT32_BOVIN Computationally mapped isoform of Ceramide kinase like OS=Bos taurus OX=9913 GN=CERKL PE=4 SV=1 CANONICAL=F1MT32-1" }, "locus": { "chromosome": "2", "start_pos": 15081251, "end_pos": 14945418, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000119802.1", "url": "https://www.ensembl.org/id/ENSBTAT00000119802.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000080619.1", "url": "https://www.ensembl.org/id/ENSBTAP00000080619.1" } ] } }, { "isoform_ac": "A0AAA9SKT3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKT3/entry", "sequence": { "sequence": "MPRRRRGGRVSALEGGREEEAPPAAGAVPSAQWASGRQPEAAAELILLRGIFEIGRDSCDVVLSERALRWQPIRPERLTGDSKYDFLHKEEFVELKDIFSVKLKRRYSIKQQGSGTLLGITLFICLKTEKNKLKDSTLDLINLSEDHCDIWFRQFKKILAGFSNRPKSLKILLNPQSHKKEATQVYYEKVEPLLKIAGIKTDVTITEYEGHALSLLKECELQGFDGVVCVGGDGSASEVAHALLLRAQKNAGLETDSILTPVGAQLPLGVIPAGHIQPVDVCTFSTIGKFLRFGFSAMFGFGGRALAVAENHRWMSPNQRMDFAIMKALAKLKPEECEISFLPFNSSQDLEERRAQGYPKSDCNNQWQMIQGQFLNVSIMAIPCQCSVAPRGLAPNTRLNNGSMALITARNTSRPEFIKHLKRYASIKNQFNFPFVDTYTVEEVKVCPKSNSSGHHPEEDHGPHETASGNCFPWNVDGDLMQVASEVHVRVHPRLINLYGRSMEEMNDSKVTCSCL", "length": 516, "header": "tr|A0AAA9SKT3-1|F1MT32_BOVIN Computationally mapped isoform of Ceramide kinase like OS=Bos taurus OX=9913 GN=CERKL PE=4 SV=1 CANONICAL=F1MT32-1" }, "locus": { "chromosome": "2", "start_pos": 15081251, "end_pos": 14945418, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129317.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129317.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084521.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084521.1" } ] } }, { "isoform_ac": "F1MEF4-1", "url": "https://www.uniprot.org/uniprotkb/F1MEF4/entry", "sequence": { "sequence": "MPRRRRGGRVSALEGGREEEAPPAAGAVPSAQWASGRQPEAAAELILLRGIFEIGRDSCDVVLSERALRWQPIRPERLTGDSKYDFLHKEEFVELKDIFSVKLKRRYSIKQQGSGTLLGITLFICLKTEKNKLKDSTLDLINLSEDHCDIWFRQFKKILAGFSNRPKSLKILLNPQSHKKEATQVYYEKVEPLLKIAGIKTDVTITEYEGHALSLLKECELQGFDGVVCVGGDGSASEVAHALLLRAQKNAGLETDSILTPVGAQLPLGVIPAGSTNVLAHSLHGVSHVVTATLHIIMGHIQPVDVCTFSTIGKFLRFGFSAMFGFGGRALAVAENHRWMSPNQRMDFAIMKALAKLKPEECEISFLPFNSSQDLEERRAQGYPKSDCNNQWQMIQGQFLNVSIMAIPCQCSVAPRGLAPNTRLNNGSMALITARNTSRPEFIKHLKRYASIKNQFNFPFVDTYTVEEVKVCPKSNSSGHHPEEDHGPHETASGNCFPWNVDGDLMQVASEVHVRVHPRLINLYGRSMEEMNDSKSISSDVKFR", "length": 544, "header": "tr|F1MEF4-1|F1MT32_BOVIN Computationally mapped isoform of Ceramide kinase like OS=Bos taurus OX=9913 GN=CERKL PE=4 SV=4 CANONICAL=F1MT32-1" }, "locus": { "chromosome": "2", "start_pos": 15081598, "end_pos": 14945418, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000012196.6", "url": "https://www.ensembl.org/id/ENSBTAT00000012196.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000012196.6", "url": "https://www.ensembl.org/id/ENSBTAP00000012196.6" } ] } }, { "isoform_ac": "F1MT32-1", "url": "https://www.uniprot.org/uniprotkb/F1MT32/entry", "sequence": { "sequence": "MPRRRRGGRVSALEGGREEEAPPAAGAVPSAQWASGRQPEAAAELILLRGIFEIGRDSCDVVLSERALRWQPIRPERLTGDSKYDFLHKEEFVELKDIFSVKLKRRYSIKQQGSGTLLGITLFICLKTEKNKLKDSTLDLINLSEDHCDIWFRQFKKILAGFSNRPKSLKILLNPQSHKKEATQVYYEKVEPLLKIAGIKTDVTITEYEGHALSLLKECELQGFDGVVCVGGDGSASEVAHALLLRAQKNAGLETDSILTPVGAQLPLGVIPAGSTNVLAHSLHGVSHVVTATLHIIMGHIQPVDVCTFSTIGKFLRFGFSAMFGFGGRALAVAENHRWMSPNQRMDFAIMKALAKLKPEECEISFLPFNSSQDLEERRAQGYPKSDCNNQWQMIQGQFLNVSIMAIPCQCSVAPRGLAPNTRLNNGSMALITARNTSRPEFIKHLKRYASIKNQFNFPFVDTYTVEEVKVCPKSNSSGHHPEEDHGPHETASGNCFPWNVDGDLMQVASEVHVRVHPRLINLYGRSMEEMNDSKDRLVLSFEEASLKITLYDHCCIVMNILNV", "length": 564, "header": "tr|F1MT32-1|F1MT32_BOVIN Isoform 1 of Ceramide kinase like OS=Bos taurus OX=9913 GN=CERKL PE=4 SV=3 CANONICAL=F1MT32-1" }, "locus": { "chromosome": "2", "start_pos": 15084060, "end_pos": 14945418, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000053825.3", "url": "https://www.ensembl.org/id/ENSBTAT00000053825.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000048677.3", "url": "https://www.ensembl.org/id/ENSBTAP00000048677.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:100337174", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:100337174", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1A017-1", "protein_name": "Ceramide kinase like", "gene_name": "CERKL", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MMGTAGPFLPRGRDRPEERRRRVAPLAAAPPEGEEEPLLRGIFEIGKTSCDVVLSARRLRWSPIVPESPAGDSSTALQVKEEIIEMKDVFSVKVKRRRFVGQKKGGTLLGITIFKCLHKEENKLTDCAIHLNNFSEDHCHSWFRRLKEILNGFQNRPKSLKVFVNPSSHKREAARIYYEQVSPLFKLADIKTDVTVTEYEGHALSVLKECELQAFDGVVCVGGDGFVSEVVHGLLLKAQIDAGKGTDYIPAPVRAPVPLGVIPAGTTNILAYTLYGIKHTVTATLHIVMGHIQPVDACTFSTPSRLLRFGFSAMFGFGARTLALAEKHRWMPSNQRKDFAFIKTLADLKTEKCELSFLPLQISQEDSHENDRKKKRKNKKKGSKDQWHKIQGDFLNVSIMAIPCLCSMAPRGLAPNTRLNNGSMALIVVRNTSRTEFIKHLKRYASVKNQFSFPFVETYTVQEVKVQLRIKSGLDAKENTDLNATAAEENYPWNIDGDLVEASEVHVRVHPQLIHLYGVNTDDLESSKATCNCI", "length": 534 }, "evidence": [ { "id": "F1MT32", "url": "https://omabrowser.org/oma/group/F1MT32/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A2AQH1-1", "protein_name": "Ceramide kinase-like", "gene_name": "Cerkl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFRGRRRSRVGALEEAPPENPKAAAEPERVLLRGIFEIRRESCDVALGERALRWRRIQPELPAGGTRHDLLSKEESLELEDIFSVKLKRRCWAKHPGRDTLLGITLFICLKEQRNKLKDSTLDLINFSEDHCDIWFRQFKKILDGFTSRPKALKILLNPQSHRKESVHVYYEKVEPLLKLAGIETDVTITEYEGHALSLLDECELRGFDGVVCVGGDGSASEAARALLLRAQKNAGVEMDCIPTLVGAELPLGFIPAGSTNALAHSLFGTPHVVTATMHIILGHIRSVDVCTFSSAGKLLCFGFSAMFGFGGRTLALAEKYRWMSPSQRRDFAIIKALAKLKPEDCKISFLLAGCSQNKQERKSQRSAESDCGGHWQTIQGQFLNISIMAMPCPCSMAPRGFTPDTRLHNGSMALRVVRNTTRSEFVKHLKRHSSVKNQFNFPFVETYIIEEVKIHPKSNSNGYSPQEEGGNHTTASEHGFPWNVDGDLMEAASEVHIRLHPRLIRLYGGSLEEMNDCKVACDCI", "length": 525 }, "evidence": [ { "id": "F1MT32", "url": "https://omabrowser.org/oma/group/F1MT32/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1M6A9-1", "protein_name": "Ceramide kinase-like", "gene_name": "Cerkl", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRRRLGSRVGALEEGAPVGCPELPKAAAEPERVLLRGIFEIGRESCDVALGERALRWQRIRPELPAGGARCDPLGKEESLDLEDIFSVKLKRRCSAKHPGSGTLLGITLFICLKEQQNKLKDSTLDLINFSEDHCDIWFRQFKRILEGFANRPKALKILLNPQSHRKESVQVYYEKVEPLLKLAGIKTDVTITEYEGHALSLLDECELRGFDGVVCVGGDGSASEAAHALLLRAQKNAGVEMDSSPTLTGAQLPLGLIPAGSTNVLAHSLFGIPHVVTATMHIILGHIQSVDVCTFSSAGKLLRFGFSAMFGFGGRTLALAEKYRWMSPSQRRDFAVIKALAKLKPEDCKISFLLAGCSQDEQERKAQRSPESDCGGHWQTIRGQFLNISIMAIPCLCSVAPRGLAPDTRLNNGSMALIAVRNTTRPEFVKHLKSYSSVKNQFNFPFVETYTIEEVKIHPKSNSNGYSPQEEGGHHATVSENGFPWNIDGDLMEAASEVHIRLHPRLIKLYGGSLEEMNDSKVACNCI", "length": 529 }, "evidence": [ { "id": "F1MT32", "url": "https://omabrowser.org/oma/group/F1MT32/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q49MI3-1", "protein_name": "Ceramide kinase-like protein", "gene_name": "CERKL", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPWRRRRNRVSALEGGREEEAPPEAAAVPPALLTSPQQTEAAAERILLRGIFEIGRDSCDVVLSERALRWRPIQPERPAGDSKYDLLCKEEFIELKDIFSVKLKRRCSVKQQRSGTLLGITLFICLKKEQNKLKNSTLDLINLSEDHCDIWFRQFKKILAGFPNRPKSLKILLNPQSHKKEATQVYYEKVEPLLKLAGIKTDVTIMEYEGHALSLLKECELQGFDGGHRKPLFAIHWSVQRLFTGMQTLEPSVVCVGGDGSASEVAHALLLRAQKNAGMETDRILTPVRAQLPLGLIPAGSTNVLAHSLHGVPHVITATLHIIMGHVQLVDVCTFSTAGKLLRFGFSAMFGFGGRTLALAEKYRWMSPNQRRDFAVVKALAKLKAEDCEISFLPFNSSDDVQERRAQGSPKSDCNDQWQMIQGQFLNVSIMAIPCLCSVAPRGLAPNTRLNNGSMALIIARNTSRPEFIKHLKRYASVKNQFNFPFVETYTVEEVKVHPRNNTGGYNPEEEEDETASENCFPWNVDGDLMEVASEVHIRLHPRLISLYGGSMEEMIPK", "length": 558 }, "evidence": [ { "id": "F1MT32", "url": "https://omabrowser.org/oma/group/F1MT32/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "kinase activity", "id": "GO:0016301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016301", "evidence": [ { "database": "UniProtKB", "id": "F1MT32", "url": "https://www.uniprot.org/uniprotkb/F1MT32" } ], "pmid": "" }, { "name": "lipid kinase activity", "id": "GO:0001727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001727", "evidence": [ { "database": "UniProtKB", "id": "F1MT32", "url": "https://www.uniprot.org/uniprotkb/F1MT32" } ], "pmid": "" }, { "name": "sphingolipid binding", "id": "GO:0046625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046625", "evidence": [ { "database": "UniProtKB", "id": "F1MT32", "url": "https://www.uniprot.org/uniprotkb/F1MT32" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MT32", "url": "https://www.uniprot.org/uniprotkb/F1MT32" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MT32", "url": "https://www.uniprot.org/uniprotkb/F1MT32" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1MT32", "url": "https://www.uniprot.org/uniprotkb/F1MT32" } ], "pmid": "" }, { "name": "photoreceptor inner segment", "id": "GO:0001917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001917", "evidence": [ { "database": "UniProtKB", "id": "F1MT32", "url": "https://www.uniprot.org/uniprotkb/F1MT32" } ], "pmid": "" }, { "name": "photoreceptor outer segment", "id": "GO:0001750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001750", "evidence": [ { "database": "UniProtKB", "id": "F1MT32", "url": "https://www.uniprot.org/uniprotkb/F1MT32" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "sphingolipid metabolic process", "id": "GO:0006665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006665", "evidence": [ { "database": "UniProtKB", "id": "F1MT32", "url": "https://www.uniprot.org/uniprotkb/F1MT32" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 142, "end_pos": 144, "annotation": "n_glycosylation_sequon" }, { "start_pos": 370, "end_pos": 372, "annotation": "n_glycosylation_sequon" }, { "start_pos": 401, "end_pos": 403, "annotation": "n_glycosylation_sequon" }, { "start_pos": 426, "end_pos": 428, "annotation": "n_glycosylation_sequon" }, { "start_pos": 436, "end_pos": 438, "annotation": "n_glycosylation_sequon" }, { "start_pos": 476, "end_pos": 478, "annotation": "n_glycosylation_sequon" }, { "start_pos": 532, "end_pos": 534, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MT32-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 564, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MT32-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MT32" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MT32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT32" }, { "id": "PS50146", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50146" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DAGKc", "eco_id": "ECO_0000259", "start_pos": 164, "end_pos": 313, "start_aa": "Asn", "end_aa": "Gly", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 142, "end_pos": 144 }, { "start_pos": 370, "end_pos": 372 }, { "start_pos": 401, "end_pos": 403 }, { "start_pos": 426, "end_pos": 428 }, { "start_pos": 436, "end_pos": 438 }, { "start_pos": 476, "end_pos": 478 }, { "start_pos": 532, "end_pos": 534 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MRL2-1", "uniprot_ac": "F1MRL2", "uniprot_id": "F1MRL2_BOVIN", "mass": { "chemical_mass": 108362.0, "monoisotopic_mass": 108362.0 }, "refseq": { "ac": "XP_024845669", "name": "Fc receptor-like protein 5 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845669" }, "gene_names": [ { "name": "FCRL5", "type": "recommended", "evidence": [ { "id": "F1MRL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRL2" } ] }, { "name": "FCRL5", "type": "synonym", "evidence": [ { "id": "XP_024845669", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845669" } ] } ], "protein_names": [ { "name": "Fc receptor like 5", "type": "synonym", "evidence": [ { "id": "F1MRL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRL2/entry#names_and_taxonomy" } ] }, { "name": "Fc receptor-like protein 5 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024845669", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845669" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MRL2", "url": "https://www.uniprot.org/uniprotkb/F1MRL2" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "FCRL5", "url": "https://www.uniprot.org/uniprotkb/F1MRL2", "locus": { "chromosome": "3", "start_pos": 12868497, "end_pos": 12804174, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000964", "url": "https://www.ensembl.org/id/ENSBTAG00000000964" } ] } } ], "crossref": [ { "id": "F1MRL2", "url": "https://alphafold.ebi.ac.uk/entry/F1MRL2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000964", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000964", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517126", "url": "https://www.ncbi.nlm.nih.gov/gene/517126", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013151", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013151", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050488", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050488", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517126", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517126", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NVPAWIE", "url": "https://omabrowser.org/oma/group/NVPAWIE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11481", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11481", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11481:SF68", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11481:SF68", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00047", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00047", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13895", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13895", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13927", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13927", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024845669", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845669", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SB19", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB19", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SB19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB19-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRL2", "url": "https://www.uniprot.org/uniprotkb/F1MRL2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRL2-1", "url": "https://www.uniprot.org/uniprotkb/F1MRL2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLWVSLLILAPVGGQFASEIKSVISLHPPWTTLFQGETVTLTCKAFQFNAPQKRKWYRWYLPGEIQSETTENTYEARESGGYKCQAQDSHSSDRVDLLFTAASLILQAPSDVFEADSVVLRCQAKANVILNNMTLYKNGKVLQVLDKTSDFHIYQASMKDNGDYHCSGFKDTHLVSSNKIKIVVQELFPSPVLKASSTQPTEGNTVTLTCETQLSLQRPESQLLFRFVKTSMWSEWKISPEFQFSPIRRENSGSYWCEARRLNSLVQKQSQELQIQVQEIVRDVRIHSHPEFVFEGQELVLICSVNGVPRPITVSWYKKQPSLWKDRELQTSSKTEFKVPVVQSSDAGEYYCIARNGRFSLESNLVIISVKVPVSQPVLTLRPPGTWTLVRDKISLQCEVQRGSLPIWYQFFHEDVLLMKTKSTSERKMSHRLSLTENHFGKYYCTADNGLGPQRSEAVIPVSKPVLTFSSPGTRTFVGDKMSLQCEVQRGSLPIWYQFFHEDDLLKKREAISWITESYSFSLIAEHSGNYYCTADNGFGPQRSESISLSVTVPVSQPVLTLSPPGTWTLVGNEVRLQCEVQRGSSPIWYQFFHEDVLLTRIEATSWRTRSYSFSVTAEHSGNYYCTADNGFGPQSSETINLSVIVPVSRPVLTLRPPRDQAVVGDVVELHCEVQRGSPPILYQFYHEDVTLGSSSSASGGGASFNLILKTEHSGNYFCEANNGQGVQRSYTVSLSVRVPVSRPVLTLRTARAQVVVGDILELRCEAQRGSTPILYWFYHNNITLETSTSHSGQGVSLNLSLTADHSGTYSCEADNGLGPQRSEAVTLSVMGLTGSKNSLIATSVTGGLLSMMAIAAVALLFYCWLLRKAGGKPTVDSSRNPSAPDPQESTYHNVPGWIELQPVYSNVNPNRGEVVYSEVWSVKKENKLTAASEPEPFKNTDSCVIYSQVKGASTTASKPQFLDPLTPHR", "length": 971, "header": "tr|F1MRL2-1|F1MRL2_BOVIN Isoform 1 of Fc receptor like 5 OS=Bos taurus OX=9913 GN=FCRL5 PE=4 SV=3 CANONICAL=F1MRL2-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SB19-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SB19/entry", "sequence": { "sequence": "MLLWVSLLILAPVGGQFASEIKSVISLHPPWTTLFQGETVTLTCKAFQFNAPQKRKWYRWYLPGEIQSETTENTYEARESGGYKCQAQDSHSSDRVDLLFTAASLILQAPSDVFEADSVVLRCQAKANVILNNMTLYKNGKVLQVLDKTSDFHIYQASMKDNELFPSPVLKASSTQPTEGNTVTLTCETQLSLQRPESQLLFRFVKTSMWSEWKISPEFQFSPIRRENSGSYWCEARRLNSLVQKQSQELQIQVQEIVRDVRIHSHPEFVFEGQELVLICSVNGVPRPITVSWYKKQPSLWKDRELQTSSKTEFKVPVVQSSDAGEYYCIARNGRFSLESNLVIISVKVPVSQPVLTLRPPGTWTLVRDKISLQCEVQRGSLPIWYQFFHEDVLLMKTKSTSERKMSHRLSLTENHFGKYYCTADNGLGPQRSEAVIPVSKPVLTFSSPGTRTFVGDKMSLQCEVQRGSLPIWYQFFHEDDLLKKREAISWITESYSFSLIAEHSGNYYCTADNGFGPQRSESISLSVTVPVSQPVLTLSPPGTWTLVGNEVRLQCEVQRGSSPIWYQFFHEDVLLTRIEATSWRTRSYSFSVTAEHSGNYYCTADNGFGPQSSETINLSVIVPVSRPVLTLRPPRDQAVVGDVVELHCEVQRGSPPILYQFYHEDVTLGSSSSASGGGASFNLILKTEHSGNYFCEANNGQGVQRSYTVSLSVRVPVSRPVLTLRTARAQVVVGDILELRCEAQRGSTPILYWFYHNNITLETSTSHSGQGVSLNLSLTADHSGTYSCEADNGLGPQRSEAVTLSVMGGKPTVDSSRNPSAPDPQESTYHNVPGWIELQPVYSNVNPNRGEVVYSEVWSVKKENKLTAASEPEPFKNTDSCVIYSQVKGASTTASKPQFLDPLTPHR", "length": 908, "header": "tr|A0AAA9SB19-1|F1MRL2_BOVIN Computationally mapped isoform of Fc receptor like 5 OS=Bos taurus OX=9913 GN=FCRL5 PE=4 SV=1 CANONICAL=F1MRL2-1" }, "locus": { "chromosome": "3", "start_pos": 12867493, "end_pos": 12804320, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000102038.1", "url": "https://www.ensembl.org/id/ENSBTAT00000102038.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083291.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083291.1" } ] } }, { "isoform_ac": "F1MRL2-1", "url": "https://www.uniprot.org/uniprotkb/F1MRL2/entry", "sequence": { "sequence": "MLLWVSLLILAPVGGQFASEIKSVISLHPPWTTLFQGETVTLTCKAFQFNAPQKRKWYRWYLPGEIQSETTENTYEARESGGYKCQAQDSHSSDRVDLLFTAASLILQAPSDVFEADSVVLRCQAKANVILNNMTLYKNGKVLQVLDKTSDFHIYQASMKDNGDYHCSGFKDTHLVSSNKIKIVVQELFPSPVLKASSTQPTEGNTVTLTCETQLSLQRPESQLLFRFVKTSMWSEWKISPEFQFSPIRRENSGSYWCEARRLNSLVQKQSQELQIQVQEIVRDVRIHSHPEFVFEGQELVLICSVNGVPRPITVSWYKKQPSLWKDRELQTSSKTEFKVPVVQSSDAGEYYCIARNGRFSLESNLVIISVKVPVSQPVLTLRPPGTWTLVRDKISLQCEVQRGSLPIWYQFFHEDVLLMKTKSTSERKMSHRLSLTENHFGKYYCTADNGLGPQRSEAVIPVSKPVLTFSSPGTRTFVGDKMSLQCEVQRGSLPIWYQFFHEDDLLKKREAISWITESYSFSLIAEHSGNYYCTADNGFGPQRSESISLSVTVPVSQPVLTLSPPGTWTLVGNEVRLQCEVQRGSSPIWYQFFHEDVLLTRIEATSWRTRSYSFSVTAEHSGNYYCTADNGFGPQSSETINLSVIVPVSRPVLTLRPPRDQAVVGDVVELHCEVQRGSPPILYQFYHEDVTLGSSSSASGGGASFNLILKTEHSGNYFCEANNGQGVQRSYTVSLSVRVPVSRPVLTLRTARAQVVVGDILELRCEAQRGSTPILYWFYHNNITLETSTSHSGQGVSLNLSLTADHSGTYSCEADNGLGPQRSEAVTLSVMGLTGSKNSLIATSVTGGLLSMMAIAAVALLFYCWLLRKAGGKPTVDSSRNPSAPDPQESTYHNVPGWIELQPVYSNVNPNRGEVVYSEVWSVKKENKLTAASEPEPFKNTDSCVIYSQVKGASTTASKPQFLDPLTPHR", "length": 971, "header": "tr|F1MRL2-1|F1MRL2_BOVIN Isoform 1 of Fc receptor like 5 OS=Bos taurus OX=9913 GN=FCRL5 PE=4 SV=3 CANONICAL=F1MRL2-1" }, "locus": { "chromosome": "3", "start_pos": 12867493, "end_pos": 12804320, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024922.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024922.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024922.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024922.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:517126", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517126", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q96RD9-1", "protein_name": "Fc receptor-like protein 5", "gene_name": "FCRL5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVPAWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVASTPVSGSLFLASSAPHR", "length": 977 }, "evidence": [ { "id": "F1MRL2", "url": "https://omabrowser.org/oma/group/F1MRL2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MRL2", "url": "https://www.uniprot.org/uniprotkb/F1MRL2" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "F1MRL2", "url": "https://www.uniprot.org/uniprotkb/F1MRL2" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "F1MRL2", "url": "https://www.uniprot.org/uniprotkb/F1MRL2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "F1MRL2", "url": "https://www.uniprot.org/uniprotkb/F1MRL2" } ], "pmid": "" }, { "name": "coreceptor activity", "id": "GO:0015026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015026", "evidence": [ { "database": "UniProtKB", "id": "F1MRL2", "url": "https://www.uniprot.org/uniprotkb/F1MRL2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "immune response", "id": "GO:0006955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "evidence": [ { "database": "UniProtKB", "id": "F1MRL2", "url": "https://www.uniprot.org/uniprotkb/F1MRL2" } ], "pmid": "" }, { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "F1MRL2", "url": "https://www.uniprot.org/uniprotkb/F1MRL2" } ], "pmid": "" }, { "name": "B cell activation", "id": "GO:0042113", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042113", "evidence": [ { "database": "UniProtKB", "id": "F1MRL2", "url": "https://www.uniprot.org/uniprotkb/F1MRL2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 642, "end_pos": 644, "annotation": "n_glycosylation_sequon" }, { "start_pos": 783, "end_pos": 785, "annotation": "n_glycosylation_sequon" }, { "start_pos": 800, "end_pos": 802, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MRL2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 971, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MRL2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MRL2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MRL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRL2" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 23, "end_pos": 101, "start_aa": "Ser", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 133, "end_pos": 135 }, { "start_pos": 642, "end_pos": 644 }, { "start_pos": 783, "end_pos": 785 }, { "start_pos": 800, "end_pos": 802 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MT09-1", "uniprot_ac": "F1MT09", "uniprot_id": "F1MT09_BOVIN", "mass": { "chemical_mass": 34670.0, "monoisotopic_mass": 34670.0 }, "refseq": { "ac": "NP_001376792", "name": "olfactory receptor family 9 subfamily Q member 6", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376792" }, "gene_names": [ { "name": "OR9Q6", "type": "recommended", "evidence": [ { "id": "F1MT09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT09" } ] }, { "name": "OR9Q2", "type": "synonym", "evidence": [ { "id": "NP_001376792", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376792" } ] }, { "name": "OR9Q6", "type": "synonym", "evidence": [ { "id": "NP_001376792", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376792" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1MT09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT09/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor family 9 subfamily Q member 6", "type": "synonym", "evidence": [ { "id": "NP_001376792", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376792" } ] }, { "name": "olfactory receptor, family 9, subfamily Q, member 2", "type": "synonym", "evidence": [ { "id": "NP_001376792", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376792" } ] } ], "function": [ { "annotation": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001376792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376792" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SBW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW7#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" }, { "database": "UniProtKB", "id": "A0AAA9TNR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNR4#function" }, { "database": "UniProtKB", "id": "F1MT09", "url": "https://www.uniprot.org/uniprotkb/F1MT09#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MT09", "url": "https://www.uniprot.org/uniprotkb/F1MT09" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR9Q6", "url": "https://www.uniprot.org/uniprotkb/F1MT09", "locus": { "chromosome": "15", "start_pos": 81373212, "end_pos": 81343283, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030908", "url": "https://www.ensembl.org/id/ENSBTAG00000030908" } ] } } ], "crossref": [ { "id": "ENSBTAG00000030908", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030908", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15230", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15230", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510573", "url": "https://www.ncbi.nlm.nih.gov/gene/510573", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510573", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510573", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FVMPACV", "url": "https://omabrowser.org/oma/group/FVMPACV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MT09", "url": "https://www.orthodb.org/?gene=F1MT09", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001376792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376792", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SBW7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SBW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNR4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNR4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TNR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNR4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MT09", "url": "https://www.uniprot.org/uniprotkb/F1MT09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MT09-1", "url": "https://www.uniprot.org/uniprotkb/F1MT09-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGRNATVVTEFLLTVFADHPHWGLPLFAVFLGFYLLTLLGNCGMILLIRQDRRLHTPMYFFLGHLALVDICYSSTVVPQVLGVLLERGVVLSRARCATQFFLFTFFASMDCYLLAIMAYDRCVAVCRPLLYVAIVTEKARWVLVVGAYAAGFSSALIRTVTAFTLSFCGNNQIDFIFCDLPPLLKLSCGDSYTQEVVIIVFAVLVMPTCILIILVSYAFIVLAIVQMRSSGGRAKTFSTCASHLAAVALFFGTLIFMYLRDNSGQSSEADRVVSVLYTVVSPMLNPLIYSLRNKEVKGAVLKSLSRPKVSGRS", "length": 314, "header": "tr|F1MT09-1|F1MT09_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9Q6 PE=3 SV=2 CANONICAL=F1MT09-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SBW7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SBW7/entry", "sequence": { "sequence": "MRHGISPPEAAKFADVQSFTYQTLSLNLFLENGLNVSSGIPLWGAGVSAFTGKPLSWMPGRNATVVTEFLLTVFADHPHWGLPLFAVFLGFYLLTLLGNCGMILLIRQDRRLHTPMYFFLGHLALVDICYSSTVVPQVLGVLLERGVVLSRARCATQFFLFTFFASMDCYLLAIMAYDRCVAVCRPLLYVAIVTEKARWVLVVGAYAAGFSSALIRTVTAFTLSFCGNNQIDFIFCDLPPLLKLSCGDSYTQEVVIIVFAVLVMPTCILIILVSYAFIVLAIVQMRSSGGRAKTFSTCASHLAAVALFFGTLIFMYLRDNSGQSSEADRVVSVLYTVVSPMLNPLIYSLRNKEVKGAVLKSLSRPKVSGRS", "length": 371, "header": "tr|A0AAA9SBW7-1|F1MT09_BOVIN Computationally mapped isoform of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9Q6 PE=3 SV=1 CANONICAL=F1MT09-1" }, "locus": { "chromosome": "15", "start_pos": 81372531, "end_pos": 81353962, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134850.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134850.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000081376.1", "url": "https://www.ensembl.org/id/ENSBTAP00000081376.1" } ] } }, { "isoform_ac": "A0AAA9TNR4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNR4/entry", "sequence": { "sequence": "MRMTQPTLVFSRAAKFADVQSFTYQTLSLNLFLENGLNVSSGIPLWGAGVSAFTGKPLSWMPGRNATVVTEFLLTVFADHPHWGLPLFAVFLGFYLLTLLGNCGMILLIRQDRRLHTPMYFFLGHLALVDICYSSTVVPQVLGVLLERGVVLSRARCATQFFLFTFFASMDCYLLAIMAYDRCVAVCRPLLYVAIVTEKARWVLVVGAYAAGFSSALIRTVTAFTLSFCGNNQIDFIFCDLPPLLKLSCGDSYTQEVVIIVFAVLVMPTCILIILVSYAFIVLAIVQMRSSGGRAKTFSTCASHLAAVALFFGTLIFMYLRDNSGQSSEADRVVSVLYTVVSPMLNPLIYSLRNKEVKGAVLKSLSRPKVSGRS", "length": 374, "header": "tr|A0AAA9TNR4-1|F1MT09_BOVIN Computationally mapped isoform of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9Q6 PE=3 SV=1 CANONICAL=F1MT09-1" }, "locus": { "chromosome": "15", "start_pos": 81372531, "end_pos": 81355877, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098769.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098769.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100205.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100205.1" } ] } }, { "isoform_ac": "F1MT09-1", "url": "https://www.uniprot.org/uniprotkb/F1MT09/entry", "sequence": { "sequence": "MPGRNATVVTEFLLTVFADHPHWGLPLFAVFLGFYLLTLLGNCGMILLIRQDRRLHTPMYFFLGHLALVDICYSSTVVPQVLGVLLERGVVLSRARCATQFFLFTFFASMDCYLLAIMAYDRCVAVCRPLLYVAIVTEKARWVLVVGAYAAGFSSALIRTVTAFTLSFCGNNQIDFIFCDLPPLLKLSCGDSYTQEVVIIVFAVLVMPTCILIILVSYAFIVLAIVQMRSSGGRAKTFSTCASHLAAVALFFGTLIFMYLRDNSGQSSEADRVVSVLYTVVSPMLNPLIYSLRNKEVKGAVLKSLSRPKVSGRS", "length": 314, "header": "tr|F1MT09-1|F1MT09_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR9Q6 PE=3 SV=2 CANONICAL=F1MT09-1" }, "locus": { "chromosome": "15", "start_pos": 81372531, "end_pos": 81371590, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037046.6", "url": "https://www.ensembl.org/id/ENSBTAT00000037046.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036889.4", "url": "https://www.ensembl.org/id/ENSBTAP00000036889.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:510573", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510573", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2M0C6-1", "protein_name": "Olfactory receptor", "gene_name": "LOC100764997", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAGRNYTFVTEFFLTAFTEHPEWRLPLFLLFLSFYLSTLLGNAGMIILIQKNRRLQTPMYFFLSHLSFVDICYSSVIIPQMLAVLWEHGTTISQARCAAQFFLFTFFASIDCYLLAIMAYDRYVAVCQPLLYVTIMTEKARIGLVTGAYVAGFSSGFIRTVTAFTLSFCGSNEINFIFCDLPPLLKLVCGDSYIQEVVIIVFAIFVMPACIVVISVSYLFIIVAIMQIRSAGGRAKTFSTCTSHLTAVALFFGTLIFMYLRDNADQPSEGDRVVSVFYTVVTPLLNPLIYSLRNKEVKEALMKSLTSKISGRP", "length": 313 }, "evidence": [ { "id": "F1MT09", "url": "https://omabrowser.org/oma/group/F1MT09/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D3ZCH0-1", "protein_name": "Olfactory receptor", "gene_name": "Or9q2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGKNYTFVTQFFLTAFTEHPEWGLPLFLLFLSFYLSTLLGNTGMIILIQKNRRLQTPMYFFLSHLSFVDICYSSVIIPQMLAVLWEHGTTISQVRCAVQFFLFTFFASIDCYLLAIMAYDRYVAVCQPLLYVTIMTEKACVGLVTGAYVAGFSSGFIRTVTAFTLSFCGSNEINFIFCDLPPLLKLVCGNSYVQEVVIIVFAIFVMPACIVVISVSYLFIIVAIMQIRSAGGRAKTFSTCTSHLTAVALFFGTLIFMYLRNNTDQFSERDRVVSVFYTVVTPLLNPLIYSLRNKEVKEAIIKSLRRSKISRGN", "length": 314 }, "evidence": [ { "id": "F1MT09", "url": "https://omabrowser.org/oma/group/F1MT09/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RMD3-1", "protein_name": "Olfactory receptor", "gene_name": "OR9Q2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAQRNYTAVREFFLSVFAEHPEWGLPLFLVFLGFYLLTLLGNAGMIFLTRKDRRLHTPMYFFLSHLSFVDICYSSTIVPQMLAVLLEHGAVISKARCAAQFFLFTFFASIDCYLLAIMAYDRYVAVCQPLLYVTIVTEKARLGLVAGAYVAGFSSAFVRTVTAFTLSFCGDNEIDFIFCDLPPLLKLTCGDSYTQEVVIIVFALFVMPACILVILVSYLFIIMAVMQIRAAGGRAKTFSTCASHLTAVALFFGTLIFMYLRDNSGQSSEADHVVSVLYTVVTPMLNPLIYSLRNKEVKDAVVKVLSQSKPSGRT", "length": 314 }, "evidence": [ { "id": "F1MT09", "url": "https://omabrowser.org/oma/group/F1MT09/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q8NGE9-1", "protein_name": "Olfactory receptor 9Q2", "gene_name": "OR9Q2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAERNYTVVTEFFLTAFTEHLQWRVPLFLIFLSFYLATMLGNTGMILLIRGDRRLHTPMYFFLSHLSLVDICYSSAIIPQMLAVLWEHGTTISQARCAAQFFLFTFFASIDCYLLAIMAYDRYTAVCQPLLYVTIITEKARWGLVTGAYVAGFFSAFVRTVTAFTLSFCGNNEINFIFCDLPPLLKLSCGDSYTQEVVIIVFALFVMPACILVILVSYLFIIVAILQIHSAGGRAKTFSTCASHLTAVALFFGTLIFMYLRDNTGQSSEGDRVVSVLYTVVTPMLNPLIYSLRNKEVKEATRKALSKSKPARRP", "length": 314 }, "evidence": [ { "id": "F1MT09", "url": "https://omabrowser.org/oma/group/F1MT09/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VG11-1", "protein_name": "Olfactory receptor", "gene_name": "Or9q2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAGRNYTFVTEFFLTAFTEHPEWGLPLFLLFLSFYLATLLGNTGMIILIQKNRRLQTPMYFFLSHLSFVDICYSSVIIPQMLAVLWEHGSTISQVRCAVQFFLFTFFASIDCYLLAIMAYDRYVAVCQPLLYVTIMTEKARVGLVTGAYVAGFSSGFIRTVTAFTLSFCGNNEINFIFCDLPPLLKLVCGDSYIQEVVIIVFAIFVMPACIVVISVSYLFIIVAIMQIRSAGGRAKTFSTCTSHLTAVALFFGTLIFMYLRDNTDQFSERDRVVSVFYTVVTPLLNPLIYSLRNKEVKEAITKSLRRSKISRAP", "length": 314 }, "evidence": [ { "id": "F1MT09", "url": "https://omabrowser.org/oma/group/F1MT09/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MT09", "url": "https://www.uniprot.org/uniprotkb/F1MT09" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1MT09", "url": "https://www.uniprot.org/uniprotkb/F1MT09" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "F1MT09", "url": "https://www.uniprot.org/uniprotkb/F1MT09" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MT09", "url": "https://www.uniprot.org/uniprotkb/F1MT09" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "F1MT09", "url": "https://www.uniprot.org/uniprotkb/F1MT09" } ], "pmid": "" }, { "name": "sensory perception of smell", "id": "GO:0007608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007608", "evidence": [ { "database": "UniProtKB", "id": "F1MT09", "url": "https://www.uniprot.org/uniprotkb/F1MT09" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MT09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MT09" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 41, "end_pos": 290, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], 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"url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00431", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1650814", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1650814", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SEF2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKP1", "url": "https://www.uniprot.org/uniprotkb/F1MKP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKP1-1", "url": "https://www.uniprot.org/uniprotkb/F1MKP1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGAGAWAPLCLLLVAAAQHSRPQLSERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANGQRIGRFCGTFRPGALVSSSNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLERPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEINDAERIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYKFRPKKLPTTTALPVTTTFPVSTTSLKPTVALCQQKCRRSGTLESNYCSSNFVPLTLVFTVLDFKNVFFCSLGRHCHHHHPSRWESACHGLDHQHLRGQSGNSAGRQEHERQGPRGLQAVPTPQKRFKLHNYGSSG", "length": 401, "header": "tr|F1MKP1-1|F1MKP1_BOVIN Isoform 1 of Procollagen C-endopeptidase enhancer 2 OS=Bos taurus OX=9913 GN=PCOLCE2 PE=4 SV=2 CANONICAL=F1MKP1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEF2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEF2/entry", "sequence": { "sequence": "MRGAGAWAPLCLLLVAAAQHSRPQLSERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANGQRIGRFCGTFRPGALVSSSNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLERPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEINDAERIGKYCGDSPPALGRHCHHHHPSRWESACHGLDHQHLRGQSGNSAGRQEHERQGPRGLQAVPTPQKRFKLHNYGSSG", "length": 302, "header": "tr|A0AAA9SEF2-1|F1MKP1_BOVIN Computationally mapped isoform of Procollagen C-endopeptidase enhancer 2 OS=Bos taurus OX=9913 GN=PCOLCE2 PE=4 SV=1 CANONICAL=F1MKP1-1" }, "locus": { "chromosome": "1", "start_pos": 126231351, "end_pos": 126132753, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116311.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116311.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082226.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082226.1" } ] } }, { "isoform_ac": "F1MKP1-1", "url": "https://www.uniprot.org/uniprotkb/F1MKP1/entry", "sequence": { "sequence": "MRGAGAWAPLCLLLVAAAQHSRPQLSERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANGQRIGRFCGTFRPGALVSSSNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLERPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEINDAERIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYKFRPKKLPTTTALPVTTTFPVSTTSLKPTVALCQQKCRRSGTLESNYCSSNFVPLTLVFTVLDFKNVFFCSLGRHCHHHHPSRWESACHGLDHQHLRGQSGNSAGRQEHERQGPRGLQAVPTPQKRFKLHNYGSSG", "length": 401, "header": "tr|F1MKP1-1|F1MKP1_BOVIN Isoform 1 of Procollagen C-endopeptidase enhancer 2 OS=Bos taurus OX=9913 GN=PCOLCE2 PE=4 SV=2 CANONICAL=F1MKP1-1" }, "locus": { "chromosome": "1", "start_pos": 126231351, "end_pos": 126132753, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000021330.7", "url": "https://www.ensembl.org/id/ENSBTAT00000021330.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000021330.6", "url": "https://www.ensembl.org/id/ENSBTAP00000021330.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], 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"evidence": [ { "database": "UniProtKB", "id": "F1MKP1", "url": "https://www.uniprot.org/uniprotkb/F1MKP1" } ], "pmid": "" }, { "name": "collagen binding", "id": "GO:0005518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005518", "evidence": [ { "database": "UniProtKB", "id": "F1MKP1", "url": "https://www.uniprot.org/uniprotkb/F1MKP1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MKP1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 401, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MKP1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MKP1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MKP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKP1" }, { "id": "PS01180", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01180" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CUB", "eco_id": "ECO_0000259", "start_pos": 33, "end_pos": 144, "start_aa": "Cys", "end_aa": "Ala", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { 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"expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MKW1", "url": "https://www.uniprot.org/uniprotkb/F1MKW1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KAZALD1", "url": "https://www.uniprot.org/uniprotkb/F1MKW1", "locus": { "chromosome": "26", "start_pos": 21894804, "end_pos": 21892430, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011489", "url": "https://www.ensembl.org/id/ENSBTAG00000011489" } ] } } ], "crossref": [ { "id": "F1MKW1", "url": "https://alphafold.ebi.ac.uk/entry/F1MKW1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011489", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011489", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00104", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00104", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "617445", "url": "https://www.ncbi.nlm.nih.gov/gene/617445", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": 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Pathway" ] }, { "id": "F1MKW1", "url": "https://www.orthodb.org/?gene=F1MKW1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14186", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14186", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14186:SF21", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14186:SF21", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00219", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00219", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07648", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07648", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002698538", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698538", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SEG8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKW1", "url": "https://www.uniprot.org/uniprotkb/F1MKW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKW1-1", "url": "https://www.uniprot.org/uniprotkb/F1MKW1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPQPPAAALALPVLLLLLLLVVRTPPPTGARPSPGPDYLRRGWLRLLAEGEGCAPCRPEECAAPRGCLAGRVRDACGCCWECANLEGQLCDLDPSAHFYGRCGEQLECRLDAGGDLSRGEVPEPLCVCRSQRPLCGSDGRTYAQICRLQEAARARPDANLTVAHPGPCETAPQILLHPYDVWNVTGQDVIFGCEVFAYPMASIEWRKDGLDIQLPGDDPHISVQFRGGPQRFEVTGWLQIQAVRPSDEGTYRCLARNALGQVEAPASLTVLTPDQLNSTGIPQLLSLHLAPEEEAESEEGEDYY", "length": 304, "header": "tr|F1MKW1-1|F1MKW1_BOVIN Isoform 1 of Kazal type serine peptidase inhibitor domain 1 OS=Bos taurus OX=9913 GN=KAZALD1 PE=4 SV=3 CANONICAL=F1MKW1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEG8/entry", "sequence": { "sequence": "MPQPPAAALALPVLLLLLLLVVRTPPPTGARPSPGPDYLRRGWLRLLAEGEGCAPCRPEECAAPRGCLAGRVRDACGCCWECANLEGQLCDLDPSAHFYGRCGEQLECRLDAGGDLSRGEVPEPLCVCRSQRPLCGSDGRTYAQICRLQEAARARPDANLTVAHPGPCETGQDVIFGCEVFAYPMASIEWRKDGLDIQLPGDDPHISVQFRGGPQRFEVTGWLQIQAVRPSDEGTYRCLARNALGQVEAPASLTVLTPDQLNSTGIPQLLSLHLAPEEEAESEEGEDYY", "length": 289, "header": "tr|A0AAA9SEG8-1|F1MKW1_BOVIN Computationally mapped isoform of Kazal type serine peptidase inhibitor domain 1 OS=Bos taurus OX=9913 GN=KAZALD1 PE=4 SV=1 CANONICAL=F1MKW1-1" }, "locus": { "chromosome": "26", "start_pos": 21894774, "end_pos": 21892480, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120448.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120448.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083790.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083790.1" } ] } }, { "isoform_ac": "F1MKW1-1", "url": "https://www.uniprot.org/uniprotkb/F1MKW1/entry", "sequence": { "sequence": "MPQPPAAALALPVLLLLLLLVVRTPPPTGARPSPGPDYLRRGWLRLLAEGEGCAPCRPEECAAPRGCLAGRVRDACGCCWECANLEGQLCDLDPSAHFYGRCGEQLECRLDAGGDLSRGEVPEPLCVCRSQRPLCGSDGRTYAQICRLQEAARARPDANLTVAHPGPCETAPQILLHPYDVWNVTGQDVIFGCEVFAYPMASIEWRKDGLDIQLPGDDPHISVQFRGGPQRFEVTGWLQIQAVRPSDEGTYRCLARNALGQVEAPASLTVLTPDQLNSTGIPQLLSLHLAPEEEAESEEGEDYY", "length": 304, "header": "tr|F1MKW1-1|F1MKW1_BOVIN Isoform 1 of Kazal type serine peptidase inhibitor domain 1 OS=Bos taurus OX=9913 GN=KAZALD1 PE=4 SV=3 CANONICAL=F1MKW1-1" }, "locus": { "chromosome": "26", "start_pos": 21894774, "end_pos": 21892480, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015268.6", "url": "https://www.ensembl.org/id/ENSBTAT00000015268.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015268.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015268.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:617445", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:617445", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MKW1", "url": "https://www.uniprot.org/uniprotkb/F1MKW1" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1MKW1", "url": "https://www.uniprot.org/uniprotkb/F1MKW1" } ], "pmid": "" }, { "name": "interstitial matrix", "id": "GO:0005614", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005614", "evidence": [ { "database": "UniProtKB", "id": "F1MKW1", "url": "https://www.uniprot.org/uniprotkb/F1MKW1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of cell growth", "id": "GO:0001558", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001558", "evidence": [ { "database": "UniProtKB", "id": "F1MKW1", "url": "https://www.uniprot.org/uniprotkb/F1MKW1" } ], "pmid": "" }, { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "F1MKW1", "url": "https://www.uniprot.org/uniprotkb/F1MKW1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "insulin-like growth factor binding", "id": "GO:0005520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005520", "evidence": [ { "database": "UniProtKB", "id": "F1MKW1", "url": "https://www.uniprot.org/uniprotkb/F1MKW1" } ], "pmid": "" }, { "name": "receptor ligand activity", "id": "GO:0048018", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048018", "evidence": [ { "database": "UniProtKB", "id": "F1MKW1", "url": "https://www.uniprot.org/uniprotkb/F1MKW1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 183, "end_pos": 185, "annotation": "n_glycosylation_sequon" }, { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MKW1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 304, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MKW1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MKW1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MKW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW1" }, { "id": "PS51323", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51323" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "IGFBP N-terminal", "eco_id": "ECO_0000259", "start_pos": 49, "end_pos": 129, "start_aa": "Glu", "end_aa": "Arg", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MKW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW1" }, { "id": "PS50835", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50835" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Ig-like", "eco_id": "ECO_0000259", "start_pos": 172, "end_pos": 269, "start_aa": "Pro", "end_aa": "Thr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MKW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW1" }, { "id": "PS51465", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51465" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Kazal-like", "eco_id": "ECO_0000259", "start_pos": 120, "end_pos": 170, "start_aa": "Glu", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 159, "end_pos": 161 }, { "start_pos": 183, "end_pos": 185 }, { "start_pos": 277, "end_pos": 279 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MSV4-1", "uniprot_ac": "F1MSV4", "uniprot_id": "F1MSV4_BOVIN", "mass": { "chemical_mass": 56528.0, "monoisotopic_mass": 56528.0 }, "refseq": {}, "gene_names": [ { "name": "SGK3", "type": "recommended", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ], "protein_names": [ { "name": "Serine/threonine-protein kinase Sgk3", "type": "recommended", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4/entry#names_and_taxonomy" } ] }, { "name": "Serum/glucocorticoid-regulated kinase 3", "type": "synonym", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MSV4", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SGK3", "url": "https://www.uniprot.org/uniprotkb/F1MSV4", "locus": { "chromosome": "14", "start_pos": 31055075, "end_pos": 30945488, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013284", "url": "https://www.ensembl.org/id/ENSBTAG00000013284" } ] } } ], "crossref": [ { "id": "F1MSV4", "url": "https://alphafold.ebi.ac.uk/entry/F1MSV4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013284", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013284", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05604", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05604", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06870", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06870", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504480", "url": "https://www.ncbi.nlm.nih.gov/gene/504480", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008271", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008271", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037709", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037709", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037900", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037900", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MSV4", "url": "https://www.orthodb.org/?gene=F1MSV4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24351", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24351", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00433", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00433", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00787", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00787", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-2672351", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SEK9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SEK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXT8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXT8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM89", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TM89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM89-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSV4", "url": "https://www.uniprot.org/uniprotkb/F1MSV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSV4-1", "url": "https://www.uniprot.org/uniprotkb/F1MSV4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLRKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRHPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSTQKVLLSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSIGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLNLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWTDLVQKKIPPPFNPNVVGPDDIRNFDAVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL", "length": 491, "header": "tr|F1MSV4-1|F1MSV4_BOVIN Isoform 1 of Serine/threonine-protein kinase Sgk3 OS=Bos taurus OX=9913 GN=SGK3 PE=3 SV=3 CANONICAL=F1MSV4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SEK9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SEK9/entry", "sequence": { "sequence": "TQRDYTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLRKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRHPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSTQKLLSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSIGHVVLTDFGLCKEGIAISDTTTTFCGTPEPPFYCRDVAEMYDNILHKPLNLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWTDLVQKKIPPPFNPNVVGPDDIRNFDAVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL", "length": 464, "header": "tr|A0AAA9SEK9-1|F1MSV4_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase Sgk3 OS=Bos taurus OX=9913 GN=SGK3 PE=3 SV=1 CANONICAL=F1MSV4-1" }, "locus": { "chromosome": "14", "start_pos": 31053390, "end_pos": 31009735, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113240.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113240.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083833.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083833.1" } ] } }, { "isoform_ac": "A0AAA9SXT8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXT8/entry", "sequence": { "sequence": "MDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLRKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRHPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSTQKLLSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSIYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLNLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWTDLVQKKIPPPFNPNVVGPDDIRNFDAVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL", "length": 461, "header": "tr|A0AAA9SXT8-1|F1MSV4_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase Sgk3 OS=Bos taurus OX=9913 GN=SGK3 PE=3 SV=1 CANONICAL=F1MSV4-1" }, "locus": { "chromosome": "14", "start_pos": 31053390, "end_pos": 31009753, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000117340.2", "url": "https://www.ensembl.org/id/ENSBTAT00000117340.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091290.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091290.1" } ] } }, { "isoform_ac": "A0AAA9TM89-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TM89/entry", "sequence": { "sequence": "MDYKESCPSVSIPSSDEHREKKKRFTLRKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRHPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSTQKLLSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSIGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLNLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWTDLVQKKIPPPFNPNVVGPDDIRNFDAVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL", "length": 462, "header": "tr|A0AAA9TM89-1|F1MSV4_BOVIN Computationally mapped isoform of Serine/threonine-protein kinase Sgk3 OS=Bos taurus OX=9913 GN=SGK3 PE=3 SV=1 CANONICAL=F1MSV4-1" }, "locus": { "chromosome": "14", "start_pos": 31053390, "end_pos": 31009753, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114429.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114429.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099496.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099496.1" } ] } }, { "isoform_ac": "F1MSV4-1", "url": "https://www.uniprot.org/uniprotkb/F1MSV4/entry", "sequence": { "sequence": "MDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLRKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRHPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSTQKVLLSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSIGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLNLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWTDLVQKKIPPPFNPNVVGPDDIRNFDAVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL", "length": 491, "header": "tr|F1MSV4-1|F1MSV4_BOVIN Isoform 1 of Serine/threonine-protein kinase Sgk3 OS=Bos taurus OX=9913 GN=SGK3 PE=3 SV=3 CANONICAL=F1MSV4-1" }, "locus": { "chromosome": "14", "start_pos": 31053390, "end_pos": 31009753, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000017667.8", "url": "https://www.ensembl.org/id/ENSBTAT00000017667.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000017667.6", "url": "https://www.ensembl.org/id/ENSBTAP00000017667.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-2672351", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2672351", "resource": "Reactome", "description": "Stimuli-sensing channels" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "F1MSV4", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MSV4", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ], "pmid": "" }, { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "F1MSV4", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ], "pmid": "" }, { "name": "potassium channel regulator activity", "id": "GO:0015459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015459", "evidence": [ { "database": "UniProtKB", "id": "F1MSV4", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ], "pmid": "" }, { "name": "protein serine kinase activity", "id": "GO:0106310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106310", "evidence": [ { "database": "UniProtKB", "id": "F1MSV4", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F1MSV4", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ], "pmid": "" }, { "name": "recycling endosome", "id": "GO:0055037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "evidence": [ { "database": "UniProtKB", "id": "F1MSV4", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1MSV4", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 467, "end_pos": 469, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] }, { "id": "R-BTA-2682349", "name": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-947590" ], "enzyme_list": [ "F1N6C1-1", "F1MSV4-1" ], "evidence": [ { "id": "R-BTA-2682349", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-2682349" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-947590", "participant_name": "Pi [plasma membrane]", "crossref": [ { "id": "C00009", "database": "COMPOUND", "url": "" }, { "id": "43474", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] } ] }, { "uniprot_ac": "A0A3Q1LQP3", "gene_name": "KSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LQP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LQP3" } ] } ] }, { "uniprot_ac": "A0A3Q1LR28", "gene_name": "TESK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A3Q1LR28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LR28" } ] } ] }, { "uniprot_ac": "A0A3Q1LRM6", "gene_name": "MAPK10", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LRM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LRM6" } ] } ] }, { "uniprot_ac": "A0A3Q1LTC6", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LTC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LTC6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { 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"A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] } ] }, { "uniprot_ac": "Q4TVR5", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4TVR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q4TVR5" } ] } ] }, { "uniprot_ac": "Q58D94", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q58D94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q58D94" } ] } ] }, { "uniprot_ac": "Q5E9L6", "gene_name": "STK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9L6" } ] } ] }, { "uniprot_ac": "Q5E9X2", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q5E9X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9X2" } ] } ] }, { "uniprot_ac": "Q5E9Y0", "gene_name": "CDK2", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5E9Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y0" } ] } ] }, { "uniprot_ac": "Q5E9Y9", "gene_name": "NME7", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5E9Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5E9Y9" } ] } ] }, { "uniprot_ac": "Q5EAB2", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q5EAB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5EAB2" } ] } ] }, { "uniprot_ac": "Q6TJY3", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q6TJY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6TJY3" } ] } ] }, { "uniprot_ac": "Q7YRC6", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q7YRC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q7YRC6", "database": "UniProtKB", "url": 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"strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000103397.1", "url": "https://www.ensembl.org/id/ENSBTAT00000103397.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097739.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097739.1" } ] } }, { "isoform_ac": "F1MLG9-1", "url": "https://www.uniprot.org/uniprotkb/F1MLG9/entry", "sequence": { "sequence": "MSLNQQDLDPDSTTDVEDVADAEEELVKKCEEMWKDMEECQNKLSLTGTETLTDSNAQLSLLIMQVKCLTAELSQWQKETPEMIPLNEEILVTLGKEEFQKLRNDLELVLSTIQSNNEKLKEDLEREQKWLDEQQQILESLNVLQNELKQQVVTFSESRIFNELKTKMRDIKEFKEKLLVTLGEFLEDHFPLPDRNVKKKKKNVQESTAQLITLHEMLEILLNRLFGVPHDPYVKISDSFWPPYIELLLRNGIALRHPEDPTRIRLEAFHQ", "length": 271, "header": "tr|F1MLG9-1|F1MLG9_BOVIN Isoform 1 of Centromere protein K OS=Bos taurus OX=9913 GN=CENPK PE=3 SV=2 CANONICAL=F1MLG9-1" }, "locus": { "chromosome": "20", "start_pos": 14035312, "end_pos": 14008880, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061053.4", "url": 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"database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "kinetochore assembly", "id": "GO:0051382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051382", "evidence": [ { "database": "UniProtKB", "id": "F1MLG9", "url": "https://www.uniprot.org/uniprotkb/F1MLG9" } ], "pmid": "" }, { "name": "mitotic sister chromatid segregation", "id": "GO:0000070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000070", "evidence": [ { "database": "UniProtKB", "id": "F1MLG9", "url": "https://www.uniprot.org/uniprotkb/F1MLG9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MLG9", "url": "https://www.uniprot.org/uniprotkb/F1MLG9" } ], "pmid": "" }, { "name": "chromosome, centromeric region", "id": "GO:0000775", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000775", "evidence": [ { "database": "UniProtKB", "id": "F1MLG9", "url": "https://www.uniprot.org/uniprotkb/F1MLG9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MLG9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 271, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MLG9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MLG9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"https://www.ensembl.org/id/ENSBTAG00000019336" } ] } } ], "crossref": [ { "id": "F1MMW6", "url": "https://alphafold.ebi.ac.uk/entry/F1MMW6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019336", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019336", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04438", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04438", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06717", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06717", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "539203", "url": "https://www.ncbi.nlm.nih.gov/gene/539203", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001158", "url": 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Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036388", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036388", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RFEEFHL", "url": "https://omabrowser.org/oma/group/RFEEFHL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10878", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10878", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10878:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10878:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00610", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00610", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00778", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00778", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02377", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02377", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12316", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12316", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-201688", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201688", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4086400", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4086400", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4641258", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641258", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-4641262", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641262", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5663220", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_024851121", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851121", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SGI1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SGI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXP5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXP5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMW6-1", "url": "https://www.uniprot.org/uniprotkb/F1MMW6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPEPAAFCADSPAELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHTTRLNGTAKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLASSLRSHHTHPSYGPPGVPPLYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPTKNFGLFDFL", "length": 718, "header": "tr|F1MMW6-1|F1MMW6_BOVIN Isoform 1 of Dishevelled segment polarity protein 3 OS=Bos taurus OX=9913 GN=DVL3 PE=3 SV=3 CANONICAL=F1MMW6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SGI1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGI1/entry", "sequence": { "sequence": "MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPEPAAFCADSPAELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHTTRLNGTAKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSSLVGNDCGPHRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLASSLRSHHTHPSYGPPGVPPLYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM", "length": 726, "header": "tr|A0AAA9SGI1-1|F1MMW6_BOVIN Computationally mapped isoform of Dishevelled segment polarity protein 3 OS=Bos taurus OX=9913 GN=DVL3 PE=3 SV=1 CANONICAL=F1MMW6-1" }, "locus": { "chromosome": "1", "start_pos": 82996621, "end_pos": 82983136, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112547.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112547.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082981.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082981.1" } ] } }, { "isoform_ac": "A0AAA9SXP5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXP5/entry", "sequence": { "sequence": "MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPEPAAFCADSPAELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHTTRLNGTAKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLASSLRSHHTHPSYGPPGVPPLYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM", "length": 680, "header": "tr|A0AAA9SXP5-1|F1MMW6_BOVIN Computationally mapped isoform of Dishevelled segment polarity protein 3 OS=Bos taurus OX=9913 GN=DVL3 PE=3 SV=1 CANONICAL=F1MMW6-1" }, "locus": { "chromosome": "1", "start_pos": 82996621, "end_pos": 82983136, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000112105.1", "url": "https://www.ensembl.org/id/ENSBTAT00000112105.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088078.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088078.1" } ] } }, { "isoform_ac": "F1MMW6-1", "url": "https://www.uniprot.org/uniprotkb/F1MMW6/entry", "sequence": { "sequence": "MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPEPAAFCADSPAELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHTTRLNGTAKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLASSLRSHHTHPSYGPPGVPPLYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPTKNFGLFDFL", "length": 718, "header": "tr|F1MMW6-1|F1MMW6_BOVIN Isoform 1 of Dishevelled segment polarity protein 3 OS=Bos taurus OX=9913 GN=DVL3 PE=3 SV=3 CANONICAL=F1MMW6-1" }, "locus": { "chromosome": "1", "start_pos": 82996621, "end_pos": 82982303, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025757.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025757.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025757.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025757.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-201688", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-201688", "resource": "Reactome", "description": "WNT mediated activation of DVL" }, { "id": "R-BTA-4086400", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4086400", "resource": "Reactome", "description": "PCP/CE pathway" }, { "id": "R-BTA-4641258", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641258", "resource": "Reactome", "description": "Degradation of DVL" }, { "id": "R-BTA-4641262", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4641262", "resource": "Reactome", "description": "Disassembly of the destruction complex and recruitment of AXIN to the membrane" }, { "id": "R-BTA-5663220", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5663220", "resource": "Reactome", "description": "RHO GTPases Activate Formins" } ], "orthologs": [ { "uniprot_canonical_ac": "D4ADV8-1", "protein_name": "Dishevelled segment polarity protein 3", "gene_name": "Dvl3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPEPAPFCADNPSELPPSMERTGGIGDSRPPSFHPHASGGSQENLDNDTETDSLVSAQRERPRRRDGPEHAARLNGTTKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYAGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLTSSLRSHHTHPSYGPPGVPPLYGPPMLMMTPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPTKNFGLFDFL", "length": 718 }, "evidence": [ { "id": "F1MMW6", "url": "https://omabrowser.org/oma/group/F1MMW6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7F737-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-3 isoform X1", "gene_name": "dvl3b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAETKIIYHLDEQETPYLIKLPIPAENVTLADFKNVLNKPNYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSADGSHGSDGGSVCADTQADLQPPLERTGGIGDSRPPSFHANAAGSQDDLGNDTEPEVGPSLRRERERERDRDRERPRRKDTHDHGGRLNGHSRAERRPDIAGYESSSTLMSSELDTTSFFDSEDDDSASRFSSSTEQSTSSRLMRRHRRRRRKPKAPRMERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPNPRSCFTLPRSEPIRPIDPAAWVSHTAAMTGAYPVYGMSPSMSTITSTSSSITSSIPETERFEDFHLSIHSDMAAVAKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHRVEGFTDRREARKYASNLLKAGYIRHTVNKITFSEQCYYIFGDVCGNMASLTLHDHDGSSGASDQDTLAPLPHPGVAPWPLAFPYQYPIPHPYNPHPVHEPGYSFTAGGGSVGSPHSEGSRSSGSNRSGTKNDTNAAPAAPESGGRSGSGSESDRREKAPSECSAAPPSEHSVRSSHTIRSIHSHTSNMVCGAAGLPPQPPVAAAPGSPPEQDLSSVPPELTASRQSFRMAMGNPSEFFVDVM", "length": 706 }, "evidence": [ { "id": "F1MMW6", "url": "https://omabrowser.org/oma/group/F1MMW6/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "I3LNW9-1", "protein_name": "Dishevelled segment polarity protein 3", "gene_name": "DVL3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPEPAPFCADNPSELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHTTRLNGTAKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDQKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPATSEHSHRSHHSLASSLRSHHTHPSYGPPGVPPLYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM", "length": 716 }, "evidence": [ { "id": "F1MMW6", "url": "https://omabrowser.org/oma/group/F1MMW6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "P51140-1", "protein_name": "Segment polarity protein dishevelled", "gene_name": "dsh", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDADRGGGQETKVIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADFGVVKEEIADDSTILPCFNGRVVSWLVSADGTNQSDNCSELPTSECELGMGLTNRKLQQQQQQHQQQQQQQQQQHQQQQQQQQQQVQPVQLAQQQQQQVLHHQKMMGNPLLQPPPLTYQSASVLSSDLDSTSLFGTESELTLDRDMTDYSSVQRLQVRKKPQRRKKRAPSMSRTSSYSSITDSTMSLNIITVSINMEAVNFLGISIVGQSNRGGDGGIYVGSIMKGGAVALDGRIEPGDMILQVNDVNFENMTNDEAVRVLREVVQKPGPIKLVVAKCWDPNPKGYFTIPRTEPVRPIDPGAWVAHTQALTSHDSIIADIAEPIKERLDQNNLEEIVKAMTKPDSGLEIRDRMWLKITIPNAFIGADAVNWVLENVEDVQDRREARRIVSAMLRSNYIKHTVNKLTFSEQCYYVVNEERNPNLLGRGHLHPHQLPHGHGGHALSHADTESITSDIGPLPNPPIYMPYSATYNPSHGYQPIQYGIAERHISSGSSSSDVLTSKDISASQSDITSVIHQANQLTIAAHGSNKSSGSSNRGGGGGGGGGGNNTNDQDVSVFNYVL", "length": 623 }, "evidence": [ { "id": "F1MMW6", "url": "https://omabrowser.org/oma/group/F1MMW6/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q61062-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-3", "gene_name": "Dvl3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPEPAPFCADNPSELPPSMERTGGIGDSRPPSFHPHASGGSQENLDNDTETDSLVSAQRERPRRRDGPEHAARLNGTTKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLTSSLRSHHTHPSYGPPGVPPLYGPPMLMMTPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM", "length": 716 }, "evidence": [ { "id": "F1MMW6", "url": "https://omabrowser.org/oma/group/F1MMW6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q92997-1", "protein_name": "Segment polarity protein dishevelled homolog DVL-3", "gene_name": "DVL3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPDPAPFCADNPSELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLASSLRSHHTHPSYGPPGVPPLYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM", "length": 716 }, "evidence": [ { "id": "F1MMW6", "url": "https://omabrowser.org/oma/group/F1MMW6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protease binding", "id": "GO:0002020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002020", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" }, { "name": "frizzled binding", "id": "GO:0005109", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005109", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" }, { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" }, { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" }, { "name": "regulation of protein localization", "id": "GO:0032880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032880", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" }, { "name": "small GTPase-mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" }, { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" }, { "name": "Wnt signaling pathway, planar cell polarity pathway", "id": "GO:0060071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060071", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "F1MMW6", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 131, "end_pos": 133, "annotation": "n_glycosylation_sequon" }, { "start_pos": 159, "end_pos": 161, "annotation": "n_glycosylation_sequon" }, { "start_pos": 309, "end_pos": 311, "annotation": "n_glycosylation_sequon" }, { "start_pos": 503, "end_pos": 505, "annotation": "n_glycosylation_sequon" }, { "start_pos": 579, "end_pos": 581, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MMW6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 718, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MMW6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MMW6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MMW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" }, { "id": "PS50186", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50186" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DEP", "eco_id": "ECO_0000259", "start_pos": 422, "end_pos": 496, "start_aa": "Pro", "end_aa": "Asp", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MMW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMW6" }, { "id": "PS50841", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50841" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DIX", "eco_id": "ECO_0000259", "start_pos": 1, "end_pos": 82, "start_aa": "Met", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MMW6", 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"length": 1094, "header": "tr|A0AAA9SGK2-1|F1MTB6_BOVIN Computationally mapped isoform of Semaphorin 5B OS=Bos taurus OX=9913 GN=SEMA5B PE=4 SV=1 CANONICAL=F1MTB6-1" }, "locus": { "chromosome": "1", "start_pos": 67277420, "end_pos": 67239731, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120714.1", "url": "https://www.ensembl.org/id/ENSBTAT00000120714.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085309.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085309.1" } ] } }, { "isoform_ac": "F1MTB6-1", "url": "https://www.uniprot.org/uniprotkb/F1MTB6/entry", "sequence": { "sequence": "MTHCMDWGRREVSAQPASGAGTTEGPTMVFPGPLAVTLLLVHLASSQDVAGEASGEQQLCSLREHPIVAFADLKPWVSNFTYPGAQDFSQLALDPSRNQLIVGARNYLFRLSLANVSLLQATEWASNEDTRRSCQSKGKTEEECQNYVRVLIVTGRKVFMCGTNAFSPVCSSRQVGNLSRTVEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSRPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFFLRENAVEHDCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQDLIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPEVGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTTSRSLRACYLEELHVLPPGRREPLRSLRIVHSARALFVGLSDGVLRVPLERCAAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITACPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCLCRSRACDSPRPRCGGLDCLGPAVHIANCSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPVPIFWASWGSWSKCSSNCGGGVQSRRRTCENGNSCPGCGVEFKTCNPEACPEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLPDPHGLQFGRRRMETRTCPADGSGACDTDALVEDLLRSGGASPLMVSGGWAAWGPWSSCSRDCELGFRFRKRTCTNPEPRNGGLPCVGDAAEYQDCNPHACPVRGAWSCWTAWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQACPEGWSPWSEWSACTEDGVQSRDRHCEELVPGPSACAGNSSQSRPCPYSEIPVILPASSVDEATSCGGFSLIHLVATGISCFLGSGLLTLAVYLSCQHCQHQSQESTLVHPATPNHLHYKGGGTPKNEKYTPMEFKTLNKNNLIPDDRANFYPLQQTNVYTTTYYPSPLNKHSFRPEASPGQRCFPNS", "length": 1113, "header": "tr|F1MTB6-1|F1MTB6_BOVIN Isoform 1 of Semaphorin 5B OS=Bos taurus OX=9913 GN=SEMA5B PE=4 SV=2 CANONICAL=F1MTB6-1" }, "locus": { "chromosome": "1", "start_pos": 67280644, "end_pos": 67239731, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024989.7", "url": "https://www.ensembl.org/id/ENSBTAT00000024989.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024989.6", "url": "https://www.ensembl.org/id/ENSBTAP00000024989.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-5173214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "resource": "Reactome", "description": "O-glycosylation of TSR domain-containing proteins" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "F1MTB6", "url": "https://www.uniprot.org/uniprotkb/F1MTB6" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MTB6", "url": "https://www.uniprot.org/uniprotkb/F1MTB6" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "F1MTB6", "url": "https://www.uniprot.org/uniprotkb/F1MTB6" } ], "pmid": "" }, { "name": "semaphorin-plexin signaling pathway", "id": "GO:0071526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071526", "evidence": [ { "database": "UniProtKB", "id": "F1MTB6", "url": "https://www.uniprot.org/uniprotkb/F1MTB6" } ], "pmid": "" }, { "name": "neural crest cell migration", "id": "GO:0001755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001755", "evidence": [ { "database": "UniProtKB", "id": "F1MTB6", "url": "https://www.uniprot.org/uniprotkb/F1MTB6" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "F1MTB6", "url": "https://www.uniprot.org/uniprotkb/F1MTB6" } ], "pmid": "" }, { "name": "axon extension", "id": "GO:0048675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048675", "evidence": [ { "database": "UniProtKB", "id": "F1MTB6", "url": "https://www.uniprot.org/uniprotkb/F1MTB6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MTB6", "url": "https://www.uniprot.org/uniprotkb/F1MTB6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MTB6", "url": "https://www.uniprot.org/uniprotkb/F1MTB6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MTB6", "url": "https://www.uniprot.org/uniprotkb/F1MTB6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "semaphorin receptor binding", "id": "GO:0030215", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030215", "evidence": [ { "database": "UniProtKB", "id": "F1MTB6", "url": "https://www.uniprot.org/uniprotkb/F1MTB6" } ], "pmid": "" }, { "name": "chemorepellent activity", "id": "GO:0045499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045499", "evidence": [ { "database": "UniProtKB", "id": "F1MTB6", "url": "https://www.uniprot.org/uniprotkb/F1MTB6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ 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"evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019132", "url": "https://www.ensembl.org/id/ENSBTAG00000019132" } ] } } ], "crossref": [ { "id": "F1MJM1", "url": "https://alphafold.ebi.ac.uk/entry/F1MJM1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019132", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019132", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR009889", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009889", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HDDNDCQ", "url": "https://omabrowser.org/oma/group/HDDNDCQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MJM1", "url": "https://www.orthodb.org/?gene=F1MJM1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23400", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23400", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23400:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23400:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07263", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07263", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000178", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SI67", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI67", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SI67-1", "url": 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"MAMKTTILLMFLWGLSCALPVARYQNTESKSSEEWKGHLAQTPTPPLESSESSEESKLSSEEQANEDPSDSTESEEVLGLDDQQHVHRPAGGLSRRGGSEGDNKDDDEDESGDDTFGDDDGGPGPEERRSGGDSRLGSDEDSADTTRSREDSTPQGDEGARDTTSESRDLDREDEGNSRPEGGDSTPDSDSEEHWVGGGSEGDSSHGDGSEFDDEGMQSDDPGAYRSERGNSRISDAGLKSRESKGDDEEQASTQDSHESPAAAYPRRKFFRKSRLPEEDGRGELDDSRTIEVMSDSTENPDSKEAGLGQSREHSKSESRQESEENRSPEDSQDVQDPSSESSQEVDLPSQENSSESQEEALHESRGDNPDNATSHSREHQADSESSEEDVLDKPSDSESTSTEEQADSESHESLRSSEESPESTEEQNSSSQEGAQTQSRSQESLSEEDDGSDSQDSSRSKEDSNSTESVSSSEEEAQTKNTEVESRKLTVDAYHNKPIGDQDDNDCQDGY", "length": 512, "header": "tr|F1MJM1-1|F1MJM1_BOVIN Isoform 1 of Dentin matrix acidic phosphoprotein 1 OS=Bos taurus OX=9913 GN=DMP1 PE=4 SV=3 CANONICAL=F1MJM1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SI67-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SI67/entry", "sequence": { "sequence": "MKTTILLMFLWGLSCALPVARYQNTESKSSEEWKGHLAQTPTPPLANEDPSDSTESEEVLGLDDQQHVHRPAGGLSRRGGSEGDNKDDDEDESGDDTFGDDDGGPGPEERRSGGDSRLGSDEDSADTTRSREDSTPQGDEGARDTTSESRDLDREDEGNSRPEGGDSTPDSDSEEHWVGGGSEGDSSHGDGSEFDDEGMQSDDPGAYRSERGNSRISDAGLKSRESKGDDEEQASTQDSHESPAAAYPRRKFFRKSRLPEEDGRGELDDSRTIEVMSDSTENPDSKEAGLGQSREHSKSESRQESEENRSPEDSQDVQDPSSESSQEVDLPSQENSSESQEEALHESRGDNPDNATSHSREHQADSESSEEDVLDKPSDSESTSTEEQADSESHESLRSSEESPESTEEQNSSSQEGAQTQSRSQESLSEEDDGSDSQDSSRSKEDSNSTESVSSSEEEAQTKNTEVESRKLTVDAYHNKPIGDQDDNDCQDGY", "length": 494, "header": "tr|A0AAA9SI67-1|F1MJM1_BOVIN Computationally mapped isoform of Dentin matrix acidic phosphoprotein 1 OS=Bos taurus OX=9913 GN=DMP1 PE=4 SV=1 CANONICAL=F1MJM1-1" }, "locus": { "chromosome": "6", "start_pos": 102541705, "end_pos": 102533373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000092552.1", "url": "https://www.ensembl.org/id/ENSBTAT00000092552.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000082237.1", "url": "https://www.ensembl.org/id/ENSBTAP00000082237.1" } ] } }, { "isoform_ac": "A0AAA9SYG8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYG8/entry", "sequence": { "sequence": "MKTTILLMFLWGLSCALPVARYQNTESKSSEEWKMGIRYNPLEQLLGVLTMSLNPKLQANEDPSDSTESEEVLGLDDQQHVHRPAGGLSRRGGSEGDNKDDDEDESGDDTFGDDDGGPGPEERRSGGDSRLGSDEDSADTTRSREDSTPQGDEGARDTTSESRDLDREDEGNSRPEGGDSTPDSDSEEHWVGGGSEGDSSHGDGSEFDDEGMQSDDPGAYRSERGNSRISDAGLKSRESKGDDEEQASTQDSHESPAAAYPRRKFFRKSRLPEEDGRGELDDSRTIEVMSDSTENPDSKEAGLGQSREHSKSESRQESEENRSPEDSQDVQDPSSESSQEVDLPSQENSSESQEEALHESRGDNPDNATSHSREHQADSESSEEDVLDKPSDSESTSTEEQADSESHESLRSSEESPESTEEQNSSSQEGAQTQSRSQESLSEEDDGSDSQDSSRSKEDSNSTESVSSSEEEAQTKNTEVESRKLTVDAYHNKPIGDQDDNDCQDGY", "length": 507, "header": "tr|A0AAA9SYG8-1|F1MJM1_BOVIN Computationally mapped isoform of Dentin matrix acidic phosphoprotein 1 OS=Bos taurus OX=9913 GN=DMP1 PE=4 SV=1 CANONICAL=F1MJM1-1" }, "locus": { "chromosome": "6", "start_pos": 102541705, "end_pos": 102533373, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098772.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098772.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088391.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088391.1" } ] } }, { "isoform_ac": "F1MJM1-1", "url": "https://www.uniprot.org/uniprotkb/F1MJM1/entry", "sequence": { "sequence": "MAMKTTILLMFLWGLSCALPVARYQNTESKSSEEWKGHLAQTPTPPLESSESSEESKLSSEEQANEDPSDSTESEEVLGLDDQQHVHRPAGGLSRRGGSEGDNKDDDEDESGDDTFGDDDGGPGPEERRSGGDSRLGSDEDSADTTRSREDSTPQGDEGARDTTSESRDLDREDEGNSRPEGGDSTPDSDSEEHWVGGGSEGDSSHGDGSEFDDEGMQSDDPGAYRSERGNSRISDAGLKSRESKGDDEEQASTQDSHESPAAAYPRRKFFRKSRLPEEDGRGELDDSRTIEVMSDSTENPDSKEAGLGQSREHSKSESRQESEENRSPEDSQDVQDPSSESSQEVDLPSQENSSESQEEALHESRGDNPDNATSHSREHQADSESSEEDVLDKPSDSESTSTEEQADSESHESLRSSEESPESTEEQNSSSQEGAQTQSRSQESLSEEDDGSDSQDSSRSKEDSNSTESVSSSEEEAQTKNTEVESRKLTVDAYHNKPIGDQDDNDCQDGY", "length": 512, "header": "tr|F1MJM1-1|F1MJM1_BOVIN Isoform 1 of Dentin matrix acidic phosphoprotein 1 OS=Bos taurus OX=9913 GN=DMP1 PE=4 SV=3 CANONICAL=F1MJM1-1" }, "locus": { "chromosome": "6", "start_pos": 102541705, "end_pos": 102533367, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025468.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025468.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025468.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025468.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 44, "start_aa": "Thr", "end_pos": 44, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr44", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-3000178", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-3000178", "resource": "Reactome", "description": "ECM proteoglycans" }, { "id": "R-BTA-381426", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-BTA-8957275", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" } ], "orthologs": [ { "uniprot_canonical_ac": "O55188-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "Dmp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKTVILLVFLWGLSCALPVARYHNTESESSEERTGDLAGSPPPPTNSESSEESQASPEGQANSDHTDSSESGEELGYDRGQYRPAGGLSKSTGTGADKEDDEDDSGDDTFGDEDNDLGPEEGQWGGPSKLDSDEDSTDTTQSSEDSTSQENSAQDTPSDSKDHDSEDEADSRPEAGDSTQDSESEEQRVGGGSEGESSHGDGSEFDDEGMQSDDPESTRSDRGHARMSSAGIRSEESKGDHEPTSTQDSDDSQSVEFSSRKSFRRSHVSEEDYRGELTDSNSRETQSDSTEDTASKEESRSESQEDTAESQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVTSESRGDNPDNTSQAGDQEDSESSEEDSLNTFSSSESQSTEEQADSESNESLSLSEESQESAQDGDSSSQEGLQSQSASTESRSQESQSEQDSRSEEDSDSQDSSRSKEESNSTGSASSSEEDIRPKNMEADSRKLIVDAYHNKPIGDQDDNDCQDGY", "length": 503 }, "evidence": [ { "id": "F1MJM1", "url": "https://omabrowser.org/oma/group/F1MJM1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P98193-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "Dmp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKTVILLTFLWGLSCALPVARYQNTESESSEERTGNLAQSPPPPMANSDHTDSSESGEELGSDRSQYRPAGGLSKSAGMDADKEEDEDDSGDDTFGDEDNGPGPEERQWGGPSRLDSDEDSADTTQSSEDSTSQENSAQDTPSDSKDHHSDEADSRPEAGDSTQDSESEEYRVGGGSEGESSHGDGSEFDDEGMQSDDPGSTRSDRGHTRMSSAGIRSEESKGDHEPTSTQDSDDSQDVEFSSRKSFRRSRVSEEDDRGELADSNSRETQSVSTEDFRSKEESRSETQEDTAETQSQEDSPEGQDPSSESSEEAGEPSQESSSESQEGVASESRGDNPDNTSQTGDQRDSESSEEDRLNTFSSSESQSTEEQGDSESNESLSLSEESQESAQDEDSSSQEGLQSQSASRESRSQESQSEQDSRSEENRDSDSQDSSRSKEESNSTGSTSSSEEDNHPKNIEADNRKLIVDAYHNKPIGDQDDNDCQDGY", "length": 489 }, "evidence": [ { "id": "F1MJM1", "url": "https://omabrowser.org/oma/group/F1MJM1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY", "length": 513 }, "evidence": [ { "id": "F1MJM1", "url": "https://omabrowser.org/oma/group/F1MJM1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "F1MJM1", "url": "https://www.uniprot.org/uniprotkb/F1MJM1" } ], "pmid": "" }, { "name": "ossification", "id": "GO:0001503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001503", "evidence": [ { "database": "UniProtKB", "id": "F1MJM1", "url": "https://www.uniprot.org/uniprotkb/F1MJM1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "F1MJM1", "url": "https://www.uniprot.org/uniprotkb/F1MJM1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "extracellular matrix binding", "id": "GO:0050840", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050840", "evidence": [ { "database": "UniProtKB", "id": "F1MJM1", "url": "https://www.uniprot.org/uniprotkb/F1MJM1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" }, { "start_pos": 353, "end_pos": 355, "annotation": "n_glycosylation_sequon" }, { "start_pos": 372, "end_pos": 374, "annotation": "n_glycosylation_sequon" }, { "start_pos": 429, "end_pos": 431, "annotation": "n_glycosylation_sequon" }, { "start_pos": 466, "end_pos": 468, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJM1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 512, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJM1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJM1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 44 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 326, "end_pos": 328 }, { "start_pos": 353, "end_pos": 355 }, { "start_pos": 372, "end_pos": 374 }, { "start_pos": 429, "end_pos": 431 }, { "start_pos": 466, "end_pos": 468 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MKC8-1", "uniprot_ac": "F1MKC8", "uniprot_id": "F1MKC8_BOVIN", "mass": { "chemical_mass": 83807.0, "monoisotopic_mass": 83807.0 }, "refseq": {}, "gene_names": [ { "name": "SLC12A8", "type": "recommended", "evidence": [ { "id": "F1MKC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC8" } ] } ], "protein_names": [ { "name": "Solute carrier family 12 member 8", "type": "synonym", "evidence": [ { "id": "F1MKC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC8/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9SIM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIM9#function" }, { "database": "UniProtKB", "id": "ARBA00057496", "url": "https://www.uniprot.org/uniprotkb/ARBA00057496#function" }, { "database": "UniProtKB", "id": "A0AAA9SRZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRZ5#function" }, { "database": "UniProtKB", "id": "A0AAA9TKH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKH1#function" }, { "database": "UniProtKB", "id": "A0AAA9TYU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYU7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MKC8", "url": "https://www.uniprot.org/uniprotkb/F1MKC8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC12A8", "url": "https://www.uniprot.org/uniprotkb/F1MKC8", "locus": { "chromosome": "1", "start_pos": 69520941, "end_pos": 69670973, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000496", "url": "https://www.ensembl.org/id/ENSBTAG00000000496" } ] } } ], "crossref": [ { "id": "F1MKC8", "url": "https://alphafold.ebi.ac.uk/entry/F1MKC8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000496", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000496", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR004841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MKC8", "url": "https://www.orthodb.org/?gene=F1MKC8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11827", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11827:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11827:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00324", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00324", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SIM9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SIM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ85", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ85", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SQ85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ85-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRZ5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRZ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRZ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYE6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKH1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKH1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKH1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYU7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TYU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYU7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKC8", "url": "https://www.uniprot.org/uniprotkb/F1MKC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKC8-1", "url": "https://www.uniprot.org/uniprotkb/F1MKC8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQISQVQELFHEAAQQEALAQPQPWWKIQLFVWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLMGMFLVSFVALVALVTVLSGIGVGEHCGVGSGGVYSMIAAVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESVSDLLSLRNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLLLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPTATGAEKCSYLLATLAVGEIRTPRARTASSPPLSRSMVPAEEPCTAEVLVELLLHARVPGPEGVMAGFNMGGDLREPAASIPLGSLVAVGISWFLYIVFVFLLGAICTREALRYDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVLVGQVNILAPIVTINFMLTYITVDYSYFSLSMGGCSLSERPELVPGEGLGALHCSEPLLLEKAPSYGSEGIAQGPSEGTLLEFTKDMDQLLQLTRKLESSQPRGGESHGILENQKGKTKKASKQTLQESFLLDLRSPASFSPGDTDGWPTASWEGQGPHGNAQSPRSEGDQPRGAYGAKLIPEPSNQPRPSREDFFLKSRLQEQGIQRRPTSFYTHICNPWVSLLGAVGSLLIMFVIQWVYTLVNIGVAAIVYFYIGRTNPGLHLGLASNFSLLRWMRSLLIPSYRSLRSPQEQIILAPSLTRVDMEMTQLTQENADFATRDRYHHSSLVSREELMPQY", "length": 773, "header": "tr|F1MKC8-1|F1MKC8_BOVIN Isoform 1 of Solute carrier family 12 member 8 OS=Bos taurus OX=9913 GN=SLC12A8 PE=4 SV=4 CANONICAL=F1MKC8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SIM9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIM9/entry", "sequence": { "sequence": "MAQISQVQELFHEAAQQEALAQPQPWWKIQLFVWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLMGMFLVSFVALVALVTVLSGIGVGEHCGVGSGGVYSMIAAVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESVSDLLSLRNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLLLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPTATGVMAGFNMGGDLREPAASIPLGSLVAVGISSSFAFTGWFLYIVFVFLLGAICTREALRYDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVLVGQVNILAPIVTINFMLTYITVDYSYFSLSMGGCSLSERPELVPGEGLGALHCSEPLLLEKAPSYGSEGIAQGPSEGTLLEFTKDMDQLLQLTRKLESSQPRGGESHGILENQKGKTKKASKQTLQESFLLDLRSPASFSPGDTDGWPTASWEGQGPHGNAQSPRSEGDQPRGAYGAKLIPEPSNQPRPSREDFFLKSRLQEQGIQRRPTSFYTHICNPWVSLLGAVGSLLIMFVIQWVYTLVNIGVAAIVYFYIGRTNPGLHLGLASNFSLLRWMRSLLIPSYRSLRSPQEQIILAPSLTRVDMEMTQLTQENADFATRDRYHHSSLVSREELMPQY", "length": 721, "header": "tr|A0AAA9SIM9-1|F1MKC8_BOVIN Computationally mapped isoform of Solute carrier family 12 member 8 OS=Bos taurus OX=9913 GN=SLC12A8 PE=4 SV=1 CANONICAL=F1MKC8-1" }, "locus": { "chromosome": "1", "start_pos": 69669505, "end_pos": 69521777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126834.1", "url": "https://www.ensembl.org/id/ENSBTAT00000126834.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000083616.1", "url": "https://www.ensembl.org/id/ENSBTAP00000083616.1" } ] } }, { "isoform_ac": "A0AAA9SQ85-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SQ85/entry", "sequence": { "sequence": "MAQISQVQELFHEAAQQEALAQPQPWWKIQLFVWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLMGMFLVSFVALVALVTVLSGIGVGEHCGVGSGGVYSMIAAVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESVSDLLSLRNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLLLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPTATGVMAGFNMGGDLREPAASIPLGSLVAVGISWFLYIVFVFLLGAICTREALRYDFLIAEKKGPNKTPVAAICLTSLVTMAFVLVGQVNILAPIVTINFMLTYITVDYSYFSLSMGGCSLSERPELVPGEGLGALHCSEPLLLEKAPSYGSEGIAQGPSEGTLLEFTKDMDQLLQLTRKLESSQPRGGESHGILENQKGKTKKASKQTLQESFLLDLRSPASFSPGDTDGWPTASWEGQGPHGNAQSPRSEGDQPRGAYGAKLIPEPSNQPRPSREDFFLKSRLQEQGIQRRPTSFYTHICNPWVSLLGAVGSLLIMFVIQWVYTLVNIGVAAIVYFYIGRTNPGLHLGLASNFSLLRWMRSLLIPSYRSLRSPQEQIILAPSLTRVDMEMTQLTQENADFATRDRYHHSSLVSREELMPQY", "length": 665, "header": "tr|A0AAA9SQ85-1|F1MKC8_BOVIN Computationally mapped isoform of Solute carrier family 12 member 8 OS=Bos taurus OX=9913 GN=SLC12A8 PE=4 SV=1 CANONICAL=F1MKC8-1" }, "locus": { "chromosome": "1", "start_pos": 69669505, "end_pos": 69521777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110985.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110985.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088490.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088490.1" } ] } }, { "isoform_ac": "A0AAA9SRZ5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRZ5/entry", "sequence": { "sequence": "MDRGAWQGAVHGVAKSQTRLSTYSIEALAQPQPWWKIQLFVWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLMGMFLVSFVALVALVTVLSGIGVGEHCGVGSGGVYSMIAAVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESVSDLLSLRNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLLLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPTATGVMAGFNMGGDLREPAASIPLGSLVAVGISWFLYIVFVFLLGAICTREALRYDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVLVGQVNILAPIVTINFMLTYITVDYSYFSLSMGGCSLSERPELVPGEGLGALHCSEPLLLEKAPSYGSEGIAQGPSEGTLLEFTKDMDQLLQLTRKLESSQPRGGESHGILENQKGKTKKASKQTLQESFLLDLRSPASFSPGDTDGWPTASWEGQGPHGNAQSPRSEGDQPRGAYGAKLIPEPSNQPRPSREDFFLKSRLQEQGIQRRPTSFYTHICNPWVSLLGAVGSLLIMFVIQWVYTLVNIGVAAIVYFYIGRTNPGLHLGLASNFSLLRWMRSLLIPSYRSLRSPQEQIILAPSLTRVDMEMTQLTQENADFATRDRYHHSSLVSREELMPQY", "length": 722, "header": "tr|A0AAA9SRZ5-1|F1MKC8_BOVIN Computationally mapped isoform of Solute carrier family 12 member 8 OS=Bos taurus OX=9913 GN=SLC12A8 PE=4 SV=1 CANONICAL=F1MKC8-1" }, "locus": { "chromosome": "1", "start_pos": 69658281, "end_pos": 69521777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108735.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108735.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085773.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085773.1" } ] } }, { "isoform_ac": "A0AAA9SYE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE6/entry", "sequence": { "sequence": "MAQISQVQELFHEAAQQEALAQPQPWWKIQLFVWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLMGMFLVSFVALVALVTVLSGIGVGEHCGVGSGGVYSMIAAVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESVSDLLSLRNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLLLLAVSTLDFVVGSFTHLDPGVMAGFNMGGDLREPAASIPLGSLVAVGISWFLYIVFVFLLGAICTREALRYDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVLVGQVNILAPIVTINFMLTYITVDYSYFSLSMGGCSLSERPELVPGEGLGALHCSEPLLLEKAPSYGSEGIAQGPSEGTLLEFTKDMDQLLQLTRKLESSQPRGGESHGILENQKGKTKKASKQTLQESFLLDLRSPASFSPGDTDGWPTASWEGQGPHGNAQSPRSEGDQPRGAYGAKLIPEPSNQPRPSREDFFLKSRLQEQGIQRRPTSFYTHICNPWVSLLGAVGSLLIMFVIQWVYTLVNIGVAAIVYFYIGRTNPGLHLGLASNFSLLRWMRSLLIPSYRSLRSPQEQIILAPSLTRVDMEMTQLTQENADFATRDRYHHSSLVSREELMPQY", "length": 676, "header": "tr|A0AAA9SYE6-1|F1MKC8_BOVIN Computationally mapped isoform of Solute carrier family 12 member 8 OS=Bos taurus OX=9913 GN=SLC12A8 PE=4 SV=1 CANONICAL=F1MKC8-1" }, "locus": { "chromosome": "1", "start_pos": 69669505, "end_pos": 69521777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093457.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093457.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091487.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091487.1" } ] } }, { "isoform_ac": "A0AAA9TKH1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKH1/entry", "sequence": { "sequence": "MDRGAWQGAVHGVAKSQTRLSTYSIGNTGVLMGMFLVSFVALVALVTVLSGIGVGEHCGVGSGGVYSMIAAVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESVSDLLSLRNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLLLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPTATGVMAGFNMGGDLREPAASIPLGSLVAVGISWFLYIVFVFLLGAICTREALRYDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVLVGQVNILAPIVTINFMLTYITVDYSYFSLSMGGCSLSERPELVPGEGLGALHCSEPLLLEKAPSYGSEGIAQGPSEGTLLEFTKDMDQLLQLTRKLESSQPRGGESHGILENQKGKTKKASKQTLQESFLLDLRSPASFSPGDTDGWPTASWEGQGPHGNAQSPRSEGDQPRGAYGAKLIPEPSNQPRPSREDFFLKSRLQEQGIQRRPTSFYTHICNPWVSLLGAVGSLLIMFVIQWVYTLVNIGVAAIVYFYIGRTNPGLHLGLASNFSLLRWMRSLLIPSYRSLRSPQEQIILAPSLTRVDMEMTQLTQENADFATRDRYHHSSLVSREELMPQY", "length": 673, "header": "tr|A0AAA9TKH1-1|F1MKC8_BOVIN Computationally mapped isoform of Solute carrier family 12 member 8 OS=Bos taurus OX=9913 GN=SLC12A8 PE=4 SV=1 CANONICAL=F1MKC8-1" }, "locus": { "chromosome": "1", "start_pos": 69658281, "end_pos": 69521777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000130729.1", "url": "https://www.ensembl.org/id/ENSBTAT00000130729.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000098892.1", "url": "https://www.ensembl.org/id/ENSBTAP00000098892.1" } ] } }, { "isoform_ac": "A0AAA9TYU7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TYU7/entry", "sequence": { "sequence": "MAQISQVQELFHEAAQQEALAQPQPWWKIQLFVWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLMGMFLVSFVALVALVTVLSGIGVGEHCGVGSGGVYSMIAAVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESVSDLLSLRNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLLLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPTATGVMAGFNMGGDLREPAASIPLGSLVAVGISWFLYIVFVFLLGAICTREALRYDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVLVGQVNILAPIVTINFMLTYITVDYSYFSLSMGGCSLSERPELVPGEGLGALHCSEPLLLEKAPSYGSEGIAQGPSEGTLLEFTKDMDQLLQLTRKLESSQPRGGESHGILENQKGKTKKASKQTLQESFLLDLRSPASFSPGDTDGWPTASWEGQGPHGNAQSPRSEGDQPRGAYGAKLIPEPSNQPRPSREDFFLKSRLQEQGIQRRPTSFYTHICNPWVSLLGAVGSLLIMFVIQWVYTLVNIGVAAIVYFYIGRTNPGLHLGLASNFSLLRWMRSLLIPSYRCSSKPKKKNTVGCFGQRSLGILLPLLHLQFPELCKIKPDLREAFFPEVSATAQELAIPPRADHFGTVSD", "length": 730, "header": "tr|A0AAA9TYU7-1|F1MKC8_BOVIN Computationally mapped isoform of Solute carrier family 12 member 8 OS=Bos taurus OX=9913 GN=SLC12A8 PE=4 SV=1 CANONICAL=F1MKC8-1" }, "locus": { "chromosome": "1", "start_pos": 69669505, "end_pos": 69521889, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000135173.1", "url": "https://www.ensembl.org/id/ENSBTAT00000135173.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101881.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101881.1" } ] } }, { "isoform_ac": "F1MKC8-1", "url": "https://www.uniprot.org/uniprotkb/F1MKC8/entry", "sequence": { "sequence": "MAQISQVQELFHEAAQQEALAQPQPWWKIQLFVWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLMGMFLVSFVALVALVTVLSGIGVGEHCGVGSGGVYSMIAAVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESVSDLLSLRNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLLLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPTATGAEKCSYLLATLAVGEIRTPRARTASSPPLSRSMVPAEEPCTAEVLVELLLHARVPGPEGVMAGFNMGGDLREPAASIPLGSLVAVGISWFLYIVFVFLLGAICTREALRYDFLIAEKVSLVGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVLVGQVNILAPIVTINFMLTYITVDYSYFSLSMGGCSLSERPELVPGEGLGALHCSEPLLLEKAPSYGSEGIAQGPSEGTLLEFTKDMDQLLQLTRKLESSQPRGGESHGILENQKGKTKKASKQTLQESFLLDLRSPASFSPGDTDGWPTASWEGQGPHGNAQSPRSEGDQPRGAYGAKLIPEPSNQPRPSREDFFLKSRLQEQGIQRRPTSFYTHICNPWVSLLGAVGSLLIMFVIQWVYTLVNIGVAAIVYFYIGRTNPGLHLGLASNFSLLRWMRSLLIPSYRSLRSPQEQIILAPSLTRVDMEMTQLTQENADFATRDRYHHSSLVSREELMPQY", "length": 773, "header": "tr|F1MKC8-1|F1MKC8_BOVIN Isoform 1 of Solute carrier family 12 member 8 OS=Bos taurus OX=9913 GN=SLC12A8 PE=4 SV=4 CANONICAL=F1MKC8-1" }, "locus": { "chromosome": "1", "start_pos": 69669505, "end_pos": 69521777, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018208.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018208.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018208.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018208.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MKC8", "url": "https://www.uniprot.org/uniprotkb/F1MKC8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "potassium ion transport", "id": "GO:0006813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006813", "evidence": [ { "database": "UniProtKB", "id": "F1MKC8", "url": "https://www.uniprot.org/uniprotkb/F1MKC8" } ], "pmid": "" }, { "name": "cell volume homeostasis", "id": "GO:0006884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006884", "evidence": [ { "database": "UniProtKB", "id": "F1MKC8", "url": "https://www.uniprot.org/uniprotkb/F1MKC8" } ], "pmid": "" }, { "name": "chloride transmembrane transport", "id": "GO:1902476", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902476", "evidence": [ { "database": "UniProtKB", "id": "F1MKC8", "url": "https://www.uniprot.org/uniprotkb/F1MKC8" } ], "pmid": "" }, { "name": "potassium ion homeostasis", "id": "GO:0055075", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055075", "evidence": [ { "database": "UniProtKB", "id": "F1MKC8", "url": "https://www.uniprot.org/uniprotkb/F1MKC8" } ], "pmid": "" }, { "name": "potassium ion import across plasma membrane", "id": "GO:1990573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990573", "evidence": [ { "database": "UniProtKB", "id": "F1MKC8", "url": "https://www.uniprot.org/uniprotkb/F1MKC8" } ], "pmid": "" }, { "name": "chloride ion homeostasis", "id": "GO:0055064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055064", "evidence": [ { "database": "UniProtKB", "id": "F1MKC8", "url": "https://www.uniprot.org/uniprotkb/F1MKC8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "chloride:monoatomic cation symporter activity", "id": "GO:0015377", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015377", "evidence": [ { "database": "UniProtKB", "id": "F1MKC8", "url": "https://www.uniprot.org/uniprotkb/F1MKC8" } ], "pmid": "" }, { "name": "potassium:chloride symporter activity", "id": "GO:0015379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015379", "evidence": [ { "database": "UniProtKB", "id": "F1MKC8", "url": "https://www.uniprot.org/uniprotkb/F1MKC8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 221, "end_pos": 223, "annotation": "n_glycosylation_sequon" }, { "start_pos": 416, "end_pos": 418, "annotation": "n_glycosylation_sequon" }, { "start_pos": 704, "end_pos": 706, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MKC8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 773, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MKC8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MKC8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MKC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC8" }, { "id": "PF00324", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00324" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Amino acid permease/ SLC12A", "eco_id": "ECO_0000259", "start_pos": 45, "end_pos": 266, "start_aa": "Val", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 221, "end_pos": 223 }, { "start_pos": 416, "end_pos": 418 }, { "start_pos": 704, "end_pos": 706 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1ML49-1", "uniprot_ac": "F1ML49", "uniprot_id": "F1ML49_BOVIN", "mass": { "chemical_mass": 115572.0, "monoisotopic_mass": 115572.0 }, "refseq": { "ac": "XP_002686526", "name": "dyslexia-associated protein KIAA0319-like protein homolog", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686526" }, "gene_names": [ { "name": "KIAA0319L", "type": "recommended", "evidence": [ { "id": "F1ML49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML49" } ] }, { "name": "KIAA0319L", "type": "synonym", "evidence": [ { "id": "XP_002686526", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686526" } ] } ], "protein_names": [ { "name": "KIAA0319 like", "type": "synonym", "evidence": [ { "id": "F1ML49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML49/entry#names_and_taxonomy" } ] }, { "name": "dyslexia-associated protein KIAA0319-like protein homolog", "type": "synonym", "evidence": [ { "id": "XP_002686526", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686526" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1ML49", "url": "https://www.uniprot.org/uniprotkb/F1ML49" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KIAA0319L", "url": "https://www.uniprot.org/uniprotkb/F1ML49", "locus": { "chromosome": "3", "start_pos": 110308038, "end_pos": 110194675, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016694", "url": "https://www.ensembl.org/id/ENSBTAG00000016694" } ] } } ], "crossref": [ { "id": "F1ML49", "url": "https://alphafold.ebi.ac.uk/entry/F1ML49", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016694", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016694", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00146", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00146", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "784489", "url": "https://www.ncbi.nlm.nih.gov/gene/784489", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000601", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000601", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029865", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029865", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035986", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035986", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:784489", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784489", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AYVIPDE", "url": "https://omabrowser.org/oma/group/AYVIPDE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1ML49", "url": "https://www.orthodb.org/?gene=F1ML49", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46182", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46182", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46182:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46182:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF22352", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22352", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23597", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23597", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23620", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23620", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002686526", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686526", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ57", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ57", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SJ57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ57-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPB7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST38", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9ST38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDD4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TDD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDD4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTB2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TTB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTB2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML49", "url": "https://www.uniprot.org/uniprotkb/F1ML49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML49-1", "url": "https://www.uniprot.org/uniprotkb/F1ML49-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKLGIKPSRASWLLSRFCWQTSVKQLKSLYLFYFCFCFSALWLSTDAKESRCQRVKTQFGVGLRSRGENHLRLLEGTPSLQSCWAACCQDSACHAFWWLEGMCLQADCSRPQSCQAFRTDSSSSMLVFFKKFQIEDDLDFLPEDDVPHILGLDWSRASWRRESPPQTPLRPTLSSDQWSLIRKLRKRENPSEEVAAVTQPSKTNELGDLNSTGSAEVHSTDTIFNPLTTDLSVKIPGRSDVSVQREASEDPGATPSIQQVKSPEKVQIAHPLPVAPSYSYATPTPQASFQSTSTPLPVIKELVVSAGNSVQITLPKNEVQLNAFVLPEPDAGEAYTYDWQLITHPRDYSGEMEGEHSKILKLSKLTPGLYEFKVIVDGQNAHGEGYVNVTVKPEPRKNRPPVAIVSPQYQEISLPTTSTVIDGSQSTDDDKIVQYHWEELKGPLREKKISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTARLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPNSKGKVMEMQGVRTPTLQLSAMQEGDYTYQLTVTDTVGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEMNKAPVAKIAGNVVITLPTDTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNRSDHHPVLFLSNLVEGTYTFHLKVTDAKGESDVDRTTVEVKPDPRKNSLVELILDVNVSQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMVFFVQNEPPHQIFKGHEVAAMLKSELQKQKADFLIFRALEISTVTCQLNCSDHGHCDSFTKRCVCDPFWMENFIKVQLRDGDSNCEWSVLYVIIASFLIVVALGILSWTVICCCKRQKGKPKRKSKYKILDATDQESLELKPTSRAGVKQKGPALSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKVRSPREEIL", "length": 1043, "header": "tr|F1ML49-1|F1ML49_BOVIN Isoform 1 of KIAA0319 like OS=Bos taurus OX=9913 GN=KIAA0319L PE=4 SV=2 CANONICAL=F1ML49-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SJ57-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ57/entry", "sequence": { "sequence": "MADGLVLPVWKAMEKLGIKPSRASWLLSRFCWQTSVKQLKSLYLFYFCFCFSALWLSTDAKESRCQRVKTQFGVGLRSRGENHLRLLEGTPSLQSCWAACCQDSACHAFWWLEGMCLQADCSRPQSCQAFRTDSSSSMLVFFKKFQIEDDLDFLPEDDVPHILGLDWSRASWRRESPPQTPLRPTLSSDQWSLIRKLRKRENPSEEVAAVTQPSKTNELGDLNSTGSAEVHSTDTIFNPLTTDLSVKIPGRSDVSVQREASEDPGATPSIQQVKSPEKVQIAHPLPVAPSYSYATPTPQASFQSTSTPLPVIKELVVSAGNSVQITLPKNEVQLNAFVLPEPDAGEAYTYDWQLITHPRDYSGEMEGEHSKILKLSKLTPGLYEFKVIVDGQNAHGEGYVNVTVKPEPRKNRPPVAIVSPQYQEISLPTTSTVIDGSQSTDDDKIVQYHWEELKGPLREKKISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTARLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPNSKGKVMEMQGVRTPTLQLSAMQEGDYTYQLTVTDTVGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEMNKAPVAKIAGNVVITLPTDTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNRSDHHPVLFLSNLVEGTYTFHLKVTDAKGESDVDRTTVEVKPDPRKNSLVELILDVNVSQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMVFFVQNEPPHQIFKGHEVAAMLKSELQKQKADFLIFRALEISTVTCQLNCSDHGHCDSFTKRCVCDPFWMENFIKVQLRDGDSNCEWSVLYVIIASFLIVVALGILSWTVICCCKRQKGKPKRKSKYKILDATDQESLELKPTSRAGVKQKGPALSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKVRSPREEIL", "length": 1055, "header": "tr|A0AAA9SJ57-1|F1ML49_BOVIN Computationally mapped isoform of KIAA0319 like OS=Bos taurus OX=9913 GN=KIAA0319L PE=4 SV=1 CANONICAL=F1ML49-1" }, "locus": { "chromosome": "3", "start_pos": 110307034, "end_pos": 110194902, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131389.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131389.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000085371.1", "url": "https://www.ensembl.org/id/ENSBTAP00000085371.1" } ] } }, { "isoform_ac": "A0AAA9SPB7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPB7/entry", "sequence": { "sequence": "MEKLGIKPSRASWLLSRFCWQTSVKQLKSLYLFYFCFCFSALWLSTDAKESRCQRVKTQFGVGLRSRGENHLRLLEGTPSLQSCWAACCQDSACHAFWWLEGMCLQADCSRPQSCQAFRTDSSSSMLVFFKKFQIEDDLDFLPEDDVPHILGLDWSRASWRRESPPQTPLRPTLSSDQWSLIRKLRKRENPSEEVAAVTQPSKTNELGDLNSTGSAEGVRTPTLQLSAMQEGDYTYQLTVTDTVGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEMNKAPVAKIAGNVVITLPTDTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNRSDHHPVLFLSNLVEGTYTFHLKVTDAKGESDVDRTTVEVKPDPRKNSLVELILDVNVSQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMVFFVQNEPPHQIFKGHEVAAMLKSELQKQKADFLIFRALEISTVTCQLNCSDHGHCDSFTKRCVCDPFWMENFIKVQLRDGDSNCEWSVLYVIIASFLIVVALGILSWTVICCCKRQKGKPKRKSKYKILDATDQESLELKPTSRAGVKQKGPALSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKVRSPREEIL", "length": 714, "header": "tr|A0AAA9SPB7-1|F1ML49_BOVIN Computationally mapped isoform of KIAA0319 like OS=Bos taurus OX=9913 GN=KIAA0319L PE=4 SV=1 CANONICAL=F1ML49-1" }, "locus": { "chromosome": "3", "start_pos": 110307034, "end_pos": 110214106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000091715.2", "url": "https://www.ensembl.org/id/ENSBTAT00000091715.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084746.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084746.1" } ] } }, { "isoform_ac": "A0AAA9ST38-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9ST38/entry", "sequence": { "sequence": "MEKLGIKPSRASWLLSRFCWQTSVKQLKSLYLFYFCFCFSALWLSTVIKELVVSAGNSVQITLPKNEVQLNAFVLPEPDAGEAYTYDWQLITHPRDYSGEMEGEHSKILKLSKLTPGLYEFKVIVDGQNAHGEGYVNVTVKPEPRKNRPPVAIVSPQYQEISLPTTSTVIDGSQSTDDDKIVQYHWEELKGPLREKKISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTARLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPNSKGKVMEMQGVRTPTLQLSAMQEGDYTYQLTVTDTVGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEMNKAPVAKIAGNVVITLPTDTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNRSDHHPVLFLSNLVEGTYTFHLKVTDAKGESDVDRTTVEVKPDPRKNSLVELILDVNVSQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMVFFVQNEPPHQIFKGHEVAAMLKSELQKQKADFLIFRALEISTVTCQLNCSDHGHCDSFTKRCVCDPFWMENFIKVQLRDGDSNCEWSVLYVIIASFLIVVALGILSWTVICCCKRQKGKPKRKSKYKILDATDQESLELKPTSRAGVKQKGPALSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKVRSPREEIL", "length": 791, "header": "tr|A0AAA9ST38-1|F1ML49_BOVIN Computationally mapped isoform of KIAA0319 like OS=Bos taurus OX=9913 GN=KIAA0319L PE=4 SV=1 CANONICAL=F1ML49-1" }, "locus": { "chromosome": "3", "start_pos": 110307034, "end_pos": 110214106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000089908.2", "url": "https://www.ensembl.org/id/ENSBTAT00000089908.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089582.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089582.1" } ] } }, { "isoform_ac": "A0AAA9TDD4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDD4/entry", "sequence": { "sequence": "MEKLGIKPSRASWLLSRFCWQTSVKQLKSLYLFYFCFCFSALWLSTDAKESRCQRVKTQFGVGLRSRGENHLRLLEGTPSLQSCWAACCQDSACHAFWWLEGMCLQADCSRPQSCQAFRTDSSSSMLVFFKKFQIEDDLDFLPEDDVPHILGLDWSRASWRRESPPQTPLRPTLSSDQWSLIRKLRKRENPSEEVAAVTQPSKTNELGDLNSTGSAEVHSTDTIFNPLTTDLSVKIPGRSDVSVQREASEDPGATPSIQQVKSPEKVQIAHPLPVAPSYSYATPTPQASFQSTSTPLPVIKELVVSAGNSVQITLPKNEVQLNAFVLPEPDAGEAYTYDWQLITHPRDYSGEMEGEHSKILKLSKLTPGLYEFKVIVDGQNAHGEGYVNVTVKPEPRKNRPPVAIVSPQYQEISLPTTSTVIDGSQSTDDDKIVQYHWEELKGPLREKKISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTARLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPNSKGKVMEMQGVRTPTLQLSAMQEGDYTYQLTVTDTVGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEDPRKNSLVELILDVNVSQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMVFFVQNEPPHQIFKGHEVAAMLKSELQKQKADFLIFRALEISTVTCQLNCSDHGHCDSFTKRCVCDPFWMENFIKVQLRDGDSNCEWSVLYVIIASFLIVVALGILSWTVICCCKRQKGKPKRKSKYKILDATDQESLELKPTSRAGVKQKGPALSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKVRSPREEIL", "length": 946, "header": "tr|A0AAA9TDD4-1|F1ML49_BOVIN Computationally mapped isoform of KIAA0319 like OS=Bos taurus OX=9913 GN=KIAA0319L PE=4 SV=1 CANONICAL=F1ML49-1" }, "locus": { "chromosome": "3", "start_pos": 110307034, "end_pos": 110214106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124564.2", "url": "https://www.ensembl.org/id/ENSBTAT00000124564.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096646.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096646.1" } ] } }, { "isoform_ac": "A0AAA9TTB2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TTB2/entry", "sequence": { "sequence": "MEKLGIKPSRASWLLSRFCWQTSVKQLKSLYLFYFCFCFSALWLSTGEAYTYDWQLITHPRDYSGEMEGEHSKILKLSKLTPGLYEFKVIVDGQNAHGEGYVNVTVKPEPRKNRPPVAIVSPQYQEISLPTTSTVIDGSQSTDDDKIVQYHWEELKGPLREKKISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTARLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPNSKGKVMEMQGVRTPTLQLSAMQEGDYTYQLTVTDTVGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEMNKAPVAKIAGNVVITLPTDTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNRSDHHPVLFLSNLVEGTYTFHLKVTDAKGESDVDRTTVEVKPDPRKNSLVELILDVNVSQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMVFFVQNEPPHQIFKGHEVAAMLKSELQKQKADFLIFRALEISTVTCQLNCSDHGHCDSFTKRCVCDPFWMENFIKVQLRDGDSNCEWSVLYVIIASFLIVVALGILSWTVICCCKRQKGKPKRKSKYKILDATDQESLELKPTSRAGVKQKGPALSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKVRSPREEIL", "length": 757, "header": "tr|A0AAA9TTB2-1|F1ML49_BOVIN Computationally mapped isoform of KIAA0319 like OS=Bos taurus OX=9913 GN=KIAA0319L PE=4 SV=1 CANONICAL=F1ML49-1" }, "locus": { "chromosome": "3", "start_pos": 110307034, "end_pos": 110214106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000128440.2", "url": "https://www.ensembl.org/id/ENSBTAT00000128440.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099771.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099771.1" } ] } }, { "isoform_ac": "F1ML49-1", "url": "https://www.uniprot.org/uniprotkb/F1ML49/entry", "sequence": { "sequence": "MEKLGIKPSRASWLLSRFCWQTSVKQLKSLYLFYFCFCFSALWLSTDAKESRCQRVKTQFGVGLRSRGENHLRLLEGTPSLQSCWAACCQDSACHAFWWLEGMCLQADCSRPQSCQAFRTDSSSSMLVFFKKFQIEDDLDFLPEDDVPHILGLDWSRASWRRESPPQTPLRPTLSSDQWSLIRKLRKRENPSEEVAAVTQPSKTNELGDLNSTGSAEVHSTDTIFNPLTTDLSVKIPGRSDVSVQREASEDPGATPSIQQVKSPEKVQIAHPLPVAPSYSYATPTPQASFQSTSTPLPVIKELVVSAGNSVQITLPKNEVQLNAFVLPEPDAGEAYTYDWQLITHPRDYSGEMEGEHSKILKLSKLTPGLYEFKVIVDGQNAHGEGYVNVTVKPEPRKNRPPVAIVSPQYQEISLPTTSTVIDGSQSTDDDKIVQYHWEELKGPLREKKISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTARLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPNSKGKVMEMQGVRTPTLQLSAMQEGDYTYQLTVTDTVGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEMNKAPVAKIAGNVVITLPTDTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNRSDHHPVLFLSNLVEGTYTFHLKVTDAKGESDVDRTTVEVKPDPRKNSLVELILDVNVSQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMVFFVQNEPPHQIFKGHEVAAMLKSELQKQKADFLIFRALEISTVTCQLNCSDHGHCDSFTKRCVCDPFWMENFIKVQLRDGDSNCEWSVLYVIIASFLIVVALGILSWTVICCCKRQKGKPKRKSKYKILDATDQESLELKPTSRAGVKQKGPALSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKVRSPREEIL", "length": 1043, "header": "tr|F1ML49-1|F1ML49_BOVIN Isoform 1 of KIAA0319 like OS=Bos taurus OX=9913 GN=KIAA0319L PE=4 SV=2 CANONICAL=F1ML49-1" }, "locus": { "chromosome": "3", "start_pos": 110307034, "end_pos": 110214106, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022196.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022196.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022196.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022196.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 255, "start_aa": "Thr", "end_pos": 255, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr255", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 285, "start_aa": "Thr", "end_pos": 285, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr285", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:784489", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:784489", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6APE1-1", "protein_name": "KIAA0319 like", "gene_name": "Kiaa0319l", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPESGAWVLVQRRKGAGRPTRARSKRLRAWTSSLVRSSLSATPPPTLGSRLELRFRRVGAGGLAQHEGVLVPPLWKAMEKRLGVKPSTTSWVLPGYCWQISVKPPRSLYLVYSFFCLSVLWLSTDANESRCHQGKTLYGAGLKTEGENHLRLLPGSLSFQACWAACCQDPACHALWWLEGMCLQADCSKPQSCQPFRTDSSHSVLIVFQKSQTAKDLGLLPEDGEPHLRRGWGRTSWRRQSLPGAPLTLSIPSSDHQSLLRERQKRDHPSVVPTRVVIQQAKANHSEEASAASPRASAEVRKTITVPSSFTSNHTTQTPEWPKNVSIPTEPSGHFTLASSTQQVKSTEHSPTDTPLPVAPSYSSATPTAQTSSQSTSAPRPVVKELVVSAGKSVQITLPKNEVQLNAFALPEPEPGETYTYDWQLITHPTDYSGEVERKHSQSLQLSKLTPGLYEFKVIVDGQNAHGEGYVNVTVKPEPRKNRPPVAVVSPQFQEISLPTTSTIIDGSQSTDDDKIVQYHWEELKGPLREEKISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTASLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGISSYEWSLSPSSKGKVVEMQGVRTPALQLSAMQEGDYTYQLTVTDTAGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSTDDQRVVSYLWEQSRGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVSVIVKEEINKPPVAKITGNVVVTLPTSTVELDGSRSSDDKGIVSYLWTRDEASPAAGEVLNHSDHHPVLFLSNLVEGSYTFHLKVTDAKGESDTDRTTVEVKPDPRKSNLVEIILDVNVSQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMLFFVQNDPPHQFFKGREVAAMLKSELRKQKADFLIFRALEINTVTCQLNCSDHGHCDSFTKRCVCDPFWMENFIKVQLRDGDSNCEWSVLYVIIASFVIVVALGILSWTTVCCCKRQDGKPKRKSRYKILDATDQESLELKPTSRAGSKQKGPTMSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKTRSPREEIL", "length": 1126 }, "evidence": [ { "id": "F1ML49", "url": "https://omabrowser.org/oma/group/F1ML49/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8V0YLA5-1", "protein_name": "KIAA0319 like", "gene_name": "KIAA0319L", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEKRLEAKLSISAPFLPRYCWGRHVRELRSLQLLYLCACLCALCSSTDANWNRSKCEPGKILLGGRLQSWEDHHLRLLEGFHTVQSCQTACCQSPACDAFWFLENMCIQVNCTVPATCQANRTGTSDSVLVFLKKSKSTEHFLKLQMENDVKAWLRRWSDWDIPVQGKKRLRRSFQKQSLAINRVQLLQGDTAARPSGEAAARASHSTSRSSRSDAERLKDQVLKHLGEDRPVPEAHPNQKKDVLKNGQNPQEQKTKSPFPPKSNNVNGSGDADSVGFPQIHVGTSAPESPVLATLSSPVALSLTAAGKTEKPELLDDASVQTHSSDTLPTVSPAQGKSTMKMQAATSVPSGVPTNSSVSPVQANTAVSLSTTATTPVMKELVVSAGDSVEVTLPKNEVQLNAFVLPEPPPGTTYSYEWELITHPKDYSGEMEGKHSQTLKLSKLTVGLYEFKVVVDGENAHGEGYVNVTVNPKPRVNRPPVAIVSPQFQEISLPTISTVIDGSQSTDDDKIVSYHWEELKGPLREEKVSSDTAILTLTNLVPGNYTFSLTVVDSDGASNSTTANLTVNKAVDYPPVANAGPNQVITLPQNSITLYGNQSTDDHSIVSYEWLLSPNSKGKVMEMQGVRTPVLQLSAMQEGDYTYQLIVTDSAGHQSTAEVTVIVQPENNKPPKADAGPDKELTLPVDSTTLDGSKSSDDQKIVSFLWEKTRGPDGVKLENANSSIATVTGLQVGTYEFTLTVKDERNLQSQSSVNVIVKEEINKPPVAKIAGNVVITLPTNTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNNSDHHPVLLLSNLVEGTYTFHLRVTDAKGESDVERTTVEVKPDPRKNNLVEIILDVNVSQLTERQKGMFIRQIGVLLGVLDSDITVQKIQPYTEQSTKMVFFVQNQPPHQIFKGREVAWTLKNELRKQQSDFLIFRALEINTVTCQLNCSEHGRCDSFTKRCVCDPFWMENFIKVQMGDGESNCEWSVLYVIIASFVIVVAFGILSWMVICCCKRRKGKSKRKSKYKILDATDQESLELKPNPKAGGRQKAQVLNTSLMHSESELDSDEAIFTWPDREKGKLLRSQNGSLRNGQVALKAKSQREEIL", "length": 1122 }, "evidence": [ { "id": "F1ML49", "url": "https://omabrowser.org/oma/group/F1ML49/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q8IZA0-1", "protein_name": "Dyslexia-associated protein KIAA0319-like protein", "gene_name": "KIAA0319L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKRLGVKPNPASWILSGYYWQTSAKWLRSLYLFYTCFCFSVLWLSTDASESRCQQGKTQFGVGLRSGGENHLWLLEGTPSLQSCWAACCQDSACHVFWWLEGMCIQADCSRPQSCRAFRTHSSNSMLVFLKKFQTADDLGFLPEDDVPHLLGLGWNWASWRQSPPRAALRPAVSSSDQQSLIRKLQKRGSPSDVVTPIVTQHSKVNDSNELGGLTTSGSAEVHKAITISSPLTTDLTAELSGGPKNVSVQPEISEGLATTPSTQQVKSSEKTQIAVPQPVAPSYSYATPTPQASFQSTSAPYPVIKELVVSAGESVQITLPKNEVQLNAYVLQEPPKGETYTYDWQLITHPRDYSGEMEGKHSQILKLSKLTPGLYEFKVIVEGQNAHGEGYVNVTVKPEPRKNRPPIAIVSPQFQEISLPTTSTVIDGSQSTDDDKIVQYHWEELKGPLREEKISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTANLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPSSKGKVVEMQGVRTPTLQLSAMQEGDYTYQLTVTDTIGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEINKPPIAKITGNVVITLPTSTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNHSDHHPILFLSNLVEGTYTFHLKVTDAKGESDTDRTTVEVKPDPRKNNLVEIILDINVSQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMVFFVQNEPPHQIFKGHEVAAMLKSELRKQKADFLIFRALEVNTVTCQLNCSDHGHCDSFTKRCICDPFWMENFIKVQLRDGDSNCEWSVLYVIIATFVIVVALGILSWTVICCCKRQKGKPKRKSKYKILDATDQESLELKPTSRAGIKQKGLLLSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKARSPREEIL", "length": 1049 }, "evidence": [ { "id": "F1ML49", "url": "https://omabrowser.org/oma/group/F1ML49/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1ML49", "url": "https://www.uniprot.org/uniprotkb/F1ML49" } ], "pmid": "" }, { "name": "trans-Golgi network membrane", "id": "GO:0032588", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032588", "evidence": [ { "database": "UniProtKB", "id": "F1ML49", "url": "https://www.uniprot.org/uniprotkb/F1ML49" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "F1ML49", "url": "https://www.uniprot.org/uniprotkb/F1ML49" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1ML49", "url": "https://www.uniprot.org/uniprotkb/F1ML49" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1ML49", "url": "https://www.uniprot.org/uniprotkb/F1ML49" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "neuron migration", "id": "GO:0001764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "evidence": [ { "database": "UniProtKB", "id": "F1ML49", "url": "https://www.uniprot.org/uniprotkb/F1ML49" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1023, "end_pos": 1025, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 389, "end_pos": 391, "annotation": "n_glycosylation_sequon" }, { "start_pos": 466, "end_pos": 468, "annotation": "n_glycosylation_sequon" }, { "start_pos": 481, "end_pos": 483, "annotation": "n_glycosylation_sequon" }, { "start_pos": 519, "end_pos": 521, "annotation": "n_glycosylation_sequon" }, { "start_pos": 643, "end_pos": 645, "annotation": "n_glycosylation_sequon" }, { "start_pos": 736, "end_pos": 738, "annotation": "n_glycosylation_sequon" }, { "start_pos": 793, "end_pos": 795, "annotation": "n_glycosylation_sequon" }, { "start_pos": 884, "end_pos": 886, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1ML49-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1043, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1ML49-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ML49" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1ML49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML49" }, { "id": "PS50986", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50986" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "MANSC", "eco_id": "ECO_0000259", "start_pos": 48, "end_pos": 126, "start_aa": "Ala", "end_aa": "Met", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1ML49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML49" }, { "id": "PS50093", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50093" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PKD", "eco_id": "ECO_0000259", "start_pos": 517, "end_pos": 586, "start_aa": "Phe", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 255, 285 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1023, "end_pos": 1025 }, { "start_pos": 211, "end_pos": 213 }, { "start_pos": 389, "end_pos": 391 }, { "start_pos": 466, "end_pos": 468 }, { "start_pos": 481, "end_pos": 483 }, { "start_pos": 519, "end_pos": 521 }, { "start_pos": 643, "end_pos": 645 }, { "start_pos": 736, "end_pos": 738 }, { "start_pos": 793, "end_pos": 795 }, { "start_pos": 884, "end_pos": 886 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MME6-1", "uniprot_ac": "F1MME6", "uniprot_id": "F1MME6_BOVIN", "mass": { "chemical_mass": 184971.0, "monoisotopic_mass": 184971.0 }, "refseq": { "ac": "XP_005224303", "name": "myomesin-1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224303" }, "gene_names": [ { "name": "MYOM1", "type": "recommended", "evidence": [ { "id": "F1MME6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MME6" } ] }, { "name": "MYOM1", "type": "synonym", "evidence": [ { "id": "XP_005224303", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224303" } ] } ], "protein_names": [ { "name": "Myomesin-1", "type": "recommended", "evidence": [ { "id": "F1MME6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MME6/entry#names_and_taxonomy" } ] }, { "name": "Myomesin family member 1", "type": "synonym", "evidence": [ { "id": "F1MME6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MME6/entry#names_and_taxonomy" } ] }, { "name": "myomesin-1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_005224303", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224303" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MME6", "url": "https://www.uniprot.org/uniprotkb/F1MME6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MYOM1", "url": "https://www.uniprot.org/uniprotkb/F1MME6", "locus": { "chromosome": "24", "start_pos": 37255784, "end_pos": 37402143, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019585", "url": "https://www.ensembl.org/id/ENSBTAG00000019585" } ] } } ], "crossref": [ { "id": "ENSBTAG00000019585", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019585", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20951", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20951", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "538404", "url": "https://www.ncbi.nlm.nih.gov/gene/538404", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060200", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060200", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MME6", "url": "https://www.orthodb.org/?gene=F1MME6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13817", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13817", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13817:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13817:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00041", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF28321", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28321", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005224303", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224303", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SL41", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL41", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SL41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL41-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MME6", "url": "https://www.uniprot.org/uniprotkb/F1MME6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MME6-1", "url": "https://www.uniprot.org/uniprotkb/F1MME6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"length": 1658, "header": "tr|F1MME6-1|F1MME6_BOVIN Isoform 1 of Myomesin-1 OS=Bos taurus OX=9913 GN=MYOM1 PE=4 SV=4 CANONICAL=F1MME6-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SL41-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SL41/entry", "sequence": { "sequence": 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"length": 1562, "header": "tr|A0AAA9SL41-1|F1MME6_BOVIN Computationally mapped isoform of Myomesin-1 OS=Bos taurus OX=9913 GN=MYOM1 PE=4 SV=1 CANONICAL=F1MME6-1" }, "locus": { "chromosome": "24", "start_pos": 37374572, "end_pos": 37256945, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000088314.1", "url": "https://www.ensembl.org/id/ENSBTAT00000088314.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000087094.1", "url": "https://www.ensembl.org/id/ENSBTAP00000087094.1" } ] } }, { "isoform_ac": "F1MME6-1", "url": "https://www.uniprot.org/uniprotkb/F1MME6/entry", "sequence": { "sequence": "MMSLPFYQKLHQHYDRSYRNRDLSTTMSQYQQEKKSSAIYTHGSTAYSSRSSAAHRQESAAFSQASAASYQHQASRASEFALSSAASHKAASAYDYGYSHGLTDSSLMLDYSSKLSPQTKRAKKSLLSGEEKENLPSDYMVPIFSGRQVHVSGITDTEEQRIKEAAAYIAQRNLLASEEGVTASKQSSVSKQSSVSKQSMSTLHQEEAFEKKSRKVAIREKADQLSLKKTLEETEAFHKKLNEDNLLHAPEFVIKPRSHTVWEKENVKLHCSVAGWPEPRLTWYKNQVPINVQAHPGKYIIESRYGMHTLEINACDFEDTAQYRASAMNAKGELSAYASVVVKRYKGELDDTRFHSGASTLPPSFAVTPYGYASRFEIHFDDKFEVSFGREGETMSLGCSVVITPEIKHFQPEIQWYRNGVPVSPSKWVQTHWSGDRATLTFSHLNKEDEGLYTVRARMGEYYEQYSAYVFVRDADAEIEGAPASPLDVVCLDANKDYIIITWKQPAVDGGSPILGYFIDKCEVGTDTWSQCNDIPVKFARFPVTGLIEGRSYIFRVRAVNKVGIGLPSRVSEPVAALDPAEKARLKSRPSAPWTGQIIVTEEEPTEGVVPGPPTDLSVIEATQSYVVLSWKPPRQRGHEGILYFVEKCEAGTENWQRVNTELPVKSPRFALFDLAEGKSYRFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKPPSNIIPSRNTDTSVVVTWEEPKDAKELVGYYIESSIVGSGKWEPCNNNPVKGTRFTCHGLKTGQSYIFRVRAVNAAGLSEYSQNSEAIEVKAAIGGGVSPDVWPELNETPGGLTDSRGGMHDTSRPTFKKDALLGSKLNKPSLPNSAHNLGQTEVSKVSETVQEALSLPSKKAALEGKSKSEPLRKKKDLAPPSPPCDITCLESFRDSMVLGWKQPDKTGGAEITGYYVNYREVIDGVPGRWREANIKAISDEAYKISNLKENMVYQFQVAAINIAGLGAPSAVSPSFKCEEWTIAVPGPPHSLKYSQVRKTSLVLQWKPPIHSGRTPVTGYFVDIKEASAREDRWRGLNQAALKHTYLKVQGLKEGESYVFRVRAINQAGVGKPSDLAGPVVAETRPGTKEVVVSVDDNGIISLNFECDQMAPSSEFTWSKDYVPTEDSPRLEVESKGNKTKMTFKDLGTEDLGIYSCDVTDTDGIASSYLIDEEELKRLLALSQEHKFPTVPVKSELAVEILEKGQVRFWMQAEKLSTNAKVNYIFNEKEIFEGPKYKMHIDRNTGIIEMFMEKLQDEDEGTYTFQVQDGRATGHSTLVLIGDVYKKLQKEAEFQRQEWIRKQGPHFAEYLSWEVTGECNVLLKCKVANIKKETSIVWYKDDREISVDEKHDFKDGICTLLITEFSKKDAGIYEVVLKDDRGKDKSRLKLVDEAFKELMTEVCKTIALSATDLKIQSTAEGIRLYSFVTYYVDDLKVNWSHNGTAIKYSDRVKSGVTGEQIWLQINEPTPNDKGKYVMELFDGKTGHQKMVDLSGQAYDEAFAEFQRLKQAAIAEKNRARVVGGLPDVVTIQEGKALNLTCIVWGDPTPEVSWLKNEKLLASDEHCNLKFEAGKTAYFTISGVRTSDSGRYGLVVKNKYGSEISDFTVSVFIPEEEARSVAEEPQKGNKKAK", "length": 1658, "header": "tr|F1MME6-1|F1MME6_BOVIN Isoform 1 of Myomesin-1 OS=Bos taurus OX=9913 GN=MYOM1 PE=4 SV=4 CANONICAL=F1MME6-1" }, "locus": { "chromosome": "24", "start_pos": 37374572, "end_pos": 37256945, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061582.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061582.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053491.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053491.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1574, "start_aa": "Thr", "end_pos": 1574, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1574", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 606, "start_aa": "Thr", "end_pos": 606, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr606", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1MME6", "url": "https://www.uniprot.org/uniprotkb/F1MME6" } ], "pmid": "" }, { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "F1MME6", "url": "https://www.uniprot.org/uniprotkb/F1MME6" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1MME6", "url": "https://www.uniprot.org/uniprotkb/F1MME6" } ], "pmid": "" }, { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "F1MME6", "url": "https://www.uniprot.org/uniprotkb/F1MME6" } ], "pmid": "" }, { "name": "structural constituent of muscle", "id": "GO:0008307", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008307", "evidence": [ { "database": "UniProtKB", "id": "F1MME6", "url": "https://www.uniprot.org/uniprotkb/F1MME6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "myosin filament", "id": "GO:0032982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032982", "evidence": [ { "database": "UniProtKB", "id": "F1MME6", "url": "https://www.uniprot.org/uniprotkb/F1MME6" } ], "pmid": "" }, { "name": "M band", "id": "GO:0031430", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031430", "evidence": [ { "database": "UniProtKB", "id": "F1MME6", "url": "https://www.uniprot.org/uniprotkb/F1MME6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "F1MME6", "url": "https://www.uniprot.org/uniprotkb/F1MME6" } ], "pmid": "" }, { "name": "sarcomere organization", "id": "GO:0045214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045214", "evidence": [ { "database": "UniProtKB", "id": "F1MME6", "url": "https://www.uniprot.org/uniprotkb/F1MME6" } ], "pmid": "" }, { "name": "positive regulation of cAMP/PKA signal transduction", "id": "GO:0141163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141163", "evidence": [ { "database": "UniProtKB", "id": "F1MME6", "url": "https://www.uniprot.org/uniprotkb/F1MME6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1164, "end_pos": 1166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1464, "end_pos": 1466, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1468, "end_pos": 1470, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1564, "end_pos": 1566, "annotation": "n_glycosylation_sequon" }, { "start_pos": 821, "end_pos": 823, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": 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"synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 606, 1574 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1164, "end_pos": 1166 }, { "start_pos": 1464, "end_pos": 1466 }, { "start_pos": 1468, "end_pos": 1470 }, { "start_pos": 1564, "end_pos": 1566 }, { "start_pos": 821, "end_pos": 823 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MP51-1", "uniprot_ac": "F1MP51", "uniprot_id": "F1MP51_BOVIN", "mass": { "chemical_mass": 111872.0, "monoisotopic_mass": 111872.0 }, "refseq": { "ac": "NP_001179918", "name": "voltage-gated delayed rectifier potassium channel KCNH5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179918" }, "gene_names": [ { "name": "KCNH5", "type": "recommended", "evidence": [ { "id": "F1MP51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP51" } ] }, { "name": "KCNH5", "type": "synonym", "evidence": [ { "id": "NP_001179918", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179918" } ] } ], "protein_names": [ { "name": "Potassium voltage-gated channel subfamily H member 5", "type": "synonym", "evidence": [ { "id": "F1MP51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP51/entry#names_and_taxonomy" } ] }, { "name": "potassium voltage-gated channel, subfamily H (eag-related), member 5", "type": "synonym", "evidence": [ { "id": "NP_001179918", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179918" } ] }, { "name": "voltage-gated delayed rectifier potassium channel KCNH5", "type": "synonym", "evidence": [ { "id": "NP_001179918", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179918" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MP51", "url": "https://www.uniprot.org/uniprotkb/F1MP51" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "KCNH5", "url": "https://www.uniprot.org/uniprotkb/F1MP51", "locus": { "chromosome": "10", "start_pos": 74939871, "end_pos": 75324314, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011379", "url": "https://www.ensembl.org/id/ENSBTAG00000011379" } ] } } ], "crossref": [ { "id": "F1MP51", "url": "https://alphafold.ebi.ac.uk/entry/F1MP51", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011379", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011379", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00038", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00038", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00130", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00130", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537813", "url": "https://www.ncbi.nlm.nih.gov/gene/537813", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000700", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000700", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003938", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003938", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003949", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003949", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014710", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018490", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018490", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537813", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537813", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PMNKTET", "url": "https://omabrowser.org/oma/group/PMNKTET/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MP51", "url": "https://www.orthodb.org/?gene=F1MP51", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10217", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10217", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10217:SF533", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10217:SF533", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00027", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00027", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13426", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13426", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1296072", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179918", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29463", "url": "https://www.rhea-db.org/rhea/29463", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SPL4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SPL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS20", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS20", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SS20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS20-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP51", "url": "https://www.uniprot.org/uniprotkb/F1MP51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP51-1", "url": "https://www.uniprot.org/uniprotkb/F1MP51-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSTQSDPERNQLQVESRSLQNGAPITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRDAMELKPSGGADPKCLKVNSPIRMKNGNGKGWLRLKNNMGTHEEKKEDWNNVTKAESMGLLSEDPKGSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKILSEKSTPPISSPKSQMPLQVPPQIPCQDIFSVSRPESPESDKDEIHF", "length": 988, "header": "tr|F1MP51-1|F1MP51_BOVIN Isoform 1 of Potassium voltage-gated channel subfamily H member 5 OS=Bos taurus OX=9913 GN=KCNH5 PE=4 SV=2 CANONICAL=F1MP51-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SPL4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SPL4/entry", "sequence": { "sequence": "MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRGWFVMANAL", "length": 624, "header": "tr|A0AAA9SPL4-1|F1MP51_BOVIN Computationally mapped isoform of Potassium voltage-gated channel subfamily H member 5 OS=Bos taurus OX=9913 GN=KCNH5 PE=4 SV=1 CANONICAL=F1MP51-1" }, "locus": { "chromosome": "10", "start_pos": 75292390, "end_pos": 74944484, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000132997.1", "url": "https://www.ensembl.org/id/ENSBTAT00000132997.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000084858.1", "url": "https://www.ensembl.org/id/ENSBTAP00000084858.1" } ] } }, { "isoform_ac": "A0AAA9SS20-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SS20/entry", "sequence": { "sequence": "MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILDHFPQ", "length": 612, "header": "tr|A0AAA9SS20-1|F1MP51_BOVIN Computationally mapped isoform of Potassium voltage-gated channel subfamily H member 5 OS=Bos taurus OX=9913 GN=KCNH5 PE=4 SV=1 CANONICAL=F1MP51-1" }, "locus": { "chromosome": "10", "start_pos": 75324314, "end_pos": 74941398, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116660.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116660.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086896.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086896.1" } ] } }, { "isoform_ac": "F1MP51-1", "url": "https://www.uniprot.org/uniprotkb/F1MP51/entry", "sequence": { "sequence": "MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSTQSDPERNQLQVESRSLQNGAPITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRDAMELKPSGGADPKCLKVNSPIRMKNGNGKGWLRLKNNMGTHEEKKEDWNNVTKAESMGLLSEDPKGSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKILSEKSTPPISSPKSQMPLQVPPQIPCQDIFSVSRPESPESDKDEIHF", "length": 988, "header": "tr|F1MP51-1|F1MP51_BOVIN Isoform 1 of Potassium voltage-gated channel subfamily H member 5 OS=Bos taurus OX=9913 GN=KCNH5 PE=4 SV=2 CANONICAL=F1MP51-1" }, "locus": { "chromosome": "10", "start_pos": 75324314, "end_pos": 74940467, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015122.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015122.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015122.5", "url": "https://www.ensembl.org/id/ENSBTAP00000015122.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:537813", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537813", "resource": "KEGG Pathway" }, { "id": "R-BTA-1296072", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1296072", "resource": "Reactome", "description": "Voltage gated Potassium channels" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A4X1WDN0-1", "protein_name": "Potassium voltage-gated channel subfamily H member 5", "gene_name": "KCNH5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSTQSDPERNQLQVESHSFQNGASITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRDAMERKPSGGADAKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLLSEDPKGSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKILSEKSVPQTSSPKSQMPLQVPPQIPCQDIFSVSRPESPESDKDEIHF", "length": 988 }, "evidence": [ { "id": "F1MP51", "url": "https://omabrowser.org/oma/group/F1MP51/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8C2LMD2-1", "protein_name": "Potassium voltage-gated channel subfamily H member 5", "gene_name": "Kcnh5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTETVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSAQSDPERSQLQVESRPLQNGASITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRDAMELKPNGGAEQRCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLLSEDPKGSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKLLSEKSLPQTPSPKPQMPLQVPPQIPCQDIFSVSRPESPESDKDEINF", "length": 988 }, "evidence": [ { "id": "F1MP51", "url": "https://omabrowser.org/oma/group/F1MP51/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0Z394-1", "protein_name": "Potassium voltage-gated channel subfamily H member 5", "gene_name": "KCNH5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEILLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKAEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIKTDSWLYQLALSIGTPYRYNTTGSGQWEGGPSKDSLYISSLYFTMTSLTTIGFGNIAPTTDGEKIFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETSLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERMRQKNEVTLSIPVDHPVRKLFQKFKQQKEMRNQGSTHIDPERNQLQVESRSVQNGASITGTSVVTVSQITPIQTSLAYVKTSEAVKQNNRDAMELKPNGNGDQKCLKVNSPMRMKNGNGKGWLRLKNTMGTHEEKKEDWNNVTKAESMGLLSEDPKCNDSENGVNKNPLRKTDSCDSGITKSDLRLDKAGETRSPLEHSPIQADARHPFYPIPEQALQTTLQEVKHELKEDIQLLSSRMAALEKQVAEILKILSEKNVPQVSSPTSHLSPQRPPQIPCQDIFSVSRPASPESEKDEIHF", "length": 989 }, "evidence": [ { "id": "F1MP51", "url": "https://omabrowser.org/oma/group/F1MP51/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q920E3-1", "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH5", "gene_name": "Kcnh5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"length": 988 }, "evidence": [ { "id": "F1MP51", "url": "https://omabrowser.org/oma/group/F1MP51/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9EPI9-1", "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH5", "gene_name": "Kcnh5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 988 }, "evidence": [ { "id": "F1MP51", "url": "https://omabrowser.org/oma/group/F1MP51/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "F1MP51", "url": "https://www.uniprot.org/uniprotkb/F1MP51" } ], "pmid": "" }, { "name": "voltage-gated potassium channel activity", "id": "GO:0005249", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005249", "evidence": [ { "database": "UniProtKB", "id": "F1MP51", "url": "https://www.uniprot.org/uniprotkb/F1MP51" } ], "pmid": "" }, { "name": "delayed rectifier potassium channel activity", "id": "GO:0005251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005251", "evidence": [ { "database": "UniProtKB", "id": "F1MP51", "url": "https://www.uniprot.org/uniprotkb/F1MP51" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "monoatomic ion channel complex", "id": "GO:0034702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034702", "evidence": [ { "database": "UniProtKB", "id": "F1MP51", "url": "https://www.uniprot.org/uniprotkb/F1MP51" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MP51", "url": "https://www.uniprot.org/uniprotkb/F1MP51" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "F1MP51", "url": "https://www.uniprot.org/uniprotkb/F1MP51" } ], "pmid": "" }, { "name": "voltage-gated potassium channel complex", "id": "GO:0008076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008076", "evidence": [ { "database": "UniProtKB", "id": "F1MP51", "url": "https://www.uniprot.org/uniprotkb/F1MP51" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of membrane potential", "id": "GO:0042391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042391", "evidence": [ { "database": "UniProtKB", "id": "F1MP51", "url": "https://www.uniprot.org/uniprotkb/F1MP51" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "F1MP51", "url": "https://www.uniprot.org/uniprotkb/F1MP51" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 403, "end_pos": 405, "annotation": "n_glycosylation_sequon" }, { "start_pos": 466, "end_pos": 468, "annotation": "n_glycosylation_sequon" }, { "start_pos": 663, "end_pos": 665, "annotation": "n_glycosylation_sequon" }, { "start_pos": 830, "end_pos": 832, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29463", "name": "", "equation": "K(+)(in) = K(+)(out)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35526-1" ], "evidence": [ { "id": "29463", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29463" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P35526", "gene_name": "CLIC5", "activity": [ { "ec_number": "1.8.-.-", "activity": "", "evidence": [ { "id": "P35526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35526" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MP51-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 988, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MP51-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MP51" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MP51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP51" }, { "id": "PS50042", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50042" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclic nucleotide-binding", "eco_id": "ECO_0000259", "start_pos": 550, "end_pos": 650, "start_aa": "Ala", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MP51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP51" }, { "id": "PS50113", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50113" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PAC", "eco_id": "ECO_0000259", "start_pos": 91, "end_pos": 143, 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Classification" ] }, { "id": "PTHR21669:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21669:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF15255", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15255", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001192696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192696", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SRW1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZK8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0B8", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0B8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9U0B8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0B8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTG3", "url": "https://www.uniprot.org/uniprotkb/F1MTG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MTG3-1", "url": "https://www.uniprot.org/uniprotkb/F1MTG3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMNRTTPDQERAPASEPVWERPWSVEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIRETKATDCRLHNVFNEFLMLSNTQFIENRVYDEEVEEPVLKTEAEKPEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANERLELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIADSEEENEEEESDEDFANHSDNDQNRHIATMSDEEEDDDGCDIFADSEKEEEDVEDMEENSRPKRSRPTSFADELAARIKGDASSRMEGERTALSPGEAKPQKTLKEKKERKTPSDDEEDNLFAPPKLTDEDFSPFGSRGGLFSGGKGLFDDEDEESDLFAEAPQDRGARTPVNEASSSSKPGKKIPAGAVSVFLGDTDVFGATSAPAPREPQKHERPPPGKSAYVPASAGLFDDDDDDDDFFSASRSKPPKTDKVESTAGIFDDEEGDLFKERTVALPEATVNQTDGNKARAETKVMLPSSKNLKLSSETKTHKGLFSDEEDSEDLFSSQSVSKSKDASVLPSKHRSSVLLFDDEDGQDNLFDTPAAKKQTSSLPTQSQKKTKPSEPPKKKASALLFSSDEEDQWHVTDSQTNSTSDKSKGEPRDPEPTHQEVKAVKKTSLFEEDDEDDLFAIAKDSQKKAQRASLLFEDDADSGSSLFGSPPTSVPPATTKKETVPEVPPLLFSDEEEKAAQSGVKPAAKKAGSAKGTSELGRTPAVEESGKEGSLNVPTQETAKNSDLFSSSSPLDKGTKSRTKTVLSLFDEEEDKTEDQSSFQALRKEVGKSPDPGTRPKSTGVFQDEELLFSHKLQKDNDPDVDLFSGTKKSRLLEPSVGSLFGDDEDDDLFSSAKSQPLIPEKKKVVKKDNSISSVKNQKHPESTQGIKEKDVWKSETPQDSPGPAPLKTKEPSPRIWKIQANLAINPAALLPPAAPQISGMKSVLPESGAPSSEPGRMQSLDRVPTPPGSGEAGVSFDLPAQADTLHCANKTRVKVRGKRRPQTRAARHLAAQESTEAEDVGSPRGFVAQLTDGATSPDGRQPPLRAAGGAEEAVAAATPTWAGGPVPGMNRGPFVKSVGQPLEDDLFDSGDIFSKGIASQSAGRKAKVKAASSLANLAEGSKDRSPMFPALGETGSDDDLFQSIKPKPAKKTNPFPFLEDEDDLFTDQRGKKNGSKSNSQQDIISKAQDIFEDDIFATEANKPSQKTREKERTFDSNLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDTDDIFSSGIQTKTTKSKSRSSQKVTESRSGQKVSNIFDDPLNAFGGQ", "length": 1333, "header": "tr|F1MTG3-1|F1MTG3_BOVIN Isoform 1 of WASH complex subunit 2C OS=Bos taurus OX=9913 GN=WASHC2C PE=3 SV=2 CANONICAL=F1MTG3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRW1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRW1/entry", "sequence": { "sequence": "MNRTTPDQERAPASEPVWERPWSVEEIRRSSQSWSLAADAGRVYDEEVEEPVLKTEAEKPEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANERLELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIADSEEENEEEESDEDFANHSDNDQNRHIATMSDEEEDDDGCDIFADSEKEEEDVEDMEENSRPKRSRPTSFADELAARIKGDASSRMEGERTALSPGEAKPQKTLKEKKERKTPSDDEEDNLFAPPKLTDEDFSPFGSRGGLFSGGKGLFDDEDEESDLFAEAPQDRGARTPVNEASSSSKPGKKIPAGAVSVFLGDTDVFGATSAPAPREPQKHERPPPGKSAYVPASAGLFDDDDDDDDFFSASRSKPPKTDKVESTAGIFDDEEGDLFKERTVALPEATVNQTDGNKARAETKVMLPSSKNLKLSSETKTHKGLFSDEEDSEDLFSSQSVSKSKDASVLPSKHRSSVLLFDDEDGQDNLFDTPAAKKQTSSLPTQSQKKTKPSEPPKKKASALLFSSDEEWHVTDSQTNSTSDKSKGEPRDPEPTHQEVKAVKKTSLFEEDDEDDLFAIAKDSQKKAQRASLLFEDDADSGSSLFGSPPTSVPPATTKKETVPEVPPLLFSDEEEKAAQSGVKPAAKKAGSAKGTSELGRTPAVEESGKEGSLNVPTQETAKNSDLFSSSSPLDKGTKSRTKTVLSLFDEEEDKTEDQSSFQALRKEVGKSPDPGTRPKSTGVFQDEELLFSHKLQKDNDPDVDLFSGTKKSRLLEPSVGSLFGDDEDDDLFSSAKSQPLIPEKKKVVKKDNSISSVKNQKHPESTQGIKEKDVWKSETPQANLAINPAALLPPAAPQISGMKSVLPESGAPSSEPGRMQSLDRVPTPPGSGEAGVSFDLPAQADTLHCANKTRVKVRGKRRPQTRAARHLAAQESTEAEDVGSPRGFVAQLTDGATSPDGRQPPLRAAGGAEEAVAAATPTWAGGPVPGMNRGPFVKSVGQPLEDDLFDSGDIFSKGIASQSAGRKAKVKAASSLANLAEGSKDRSPMFPALGETGSDDDLFQSIKPKPAKKTNPFPFLEDEDDLFTDQRGKKNGSKSNSQQDIISKAQDIFEDDIFATEANKPSQKTREKERTFDSNLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDTDDIFSSGIQTKTTKSKSRSSQKVTESRSGQKVSNIFDDPLNAFGGQ", "length": 1254, "header": "tr|A0AAA9SRW1-1|F1MTG3_BOVIN Computationally mapped isoform of WASH complex subunit 2C OS=Bos taurus OX=9913 GN=WASHC2C PE=3 SV=1 CANONICAL=F1MTG3-1" }, "locus": { "chromosome": "28", "start_pos": 44157617, "end_pos": 44113077, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000136019.2", "url": "https://www.ensembl.org/id/ENSBTAT00000136019.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086813.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086813.1" } ] } }, { "isoform_ac": "A0AAA9SYE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYE5/entry", "sequence": { "sequence": "MMNRTTPDQERAPASEPVWERPWSVEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIRETKATDCRLHNVFNEFLMLSNTQFIENRVYDEEVEEPVLKTEAEKPEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANERLELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIADSEEENEEEESDEDFANHSDNDQNRHIATMSDEEEDDDGCDIFADSEKEEEDVEDMEENSRPKRSRPTSFADELAARIKGDASSRMEGERTDEEDNLFAPPKLTDEDFSPFGSRGGLFSGGKGLFDDEDEESDLFAEAPQDRGARTPVNEASSSSKPGKKIPAGAVSVFLGDTDVFGATSAPAPREPQKHERPPPGKSAYVPASAGLFDDDDDDDDFFSASRSKPPKTDKVESTAGIFDDEEGDLFKERTVALPEATVNQTDGNKARAETKVMLPSSKNLKLSSETKTHKGLFSDEEDSEDLFSSQSVSKSKDASVLPSKHRSSVLLFDDEDGQDNLFDTPAAKKQTSSLPTQSQKKTKPSEPPKKKASALLFSSDEEDQWHVTDSQTNSTSDKSKGEPRDPEPTHQEVKAVKKTSLFEEDDEDDLFAIAKDSQKKAQRASLLFEDDADSGSSLFGSPPTSVPPATTEGSLNVPTQETAKNSDLFSSSSPLDKGTKSRTKTVLSLFDEEEDKTEDQSSFQALRKEVGKSPDPGTRPKSTGVFQDEELLFSHKLQKDNDPDVDLFSGTKKSRLLEPSVGSLFGDDEDDDLFSSAKSQPLIPEKKKVVKKDNSISSVKNQKHPESTQGIKEKDVWKSETPQANLAINPAALLPPAAPQISGMKSVLPESGAPSSEPGRMQSLDRVPTPPGSGEAGVSFDLPAQADTLHCANKTRVKVRGKRRPQTRAARHLAAQESTEAEDVGSPRGFVAQLTDGATSPDGRQPPLRAAGGAEEAVAAATPTWAGGPVPGMNRGPFVKSVGQPLEDDLFDSGDIFSKGIASQSAGRKAKVKAASSLANLAEGSKDRSPMFPALGETGSDDDLFQSIKPKPAKKTNPFPFLEDEDDLFTDQRGKKNGSKSNSQQDIISKAQDIFEDDIFATEANKPSQKTREKERTFDSNLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDTDDIFSSGIQTKTTKSKSRSSQKVTESRSGQKVSNIFDDPLNAFGGQ", "length": 1236, "header": "tr|A0AAA9SYE5-1|F1MTG3_BOVIN Computationally mapped isoform of WASH complex subunit 2C OS=Bos taurus OX=9913 GN=WASHC2C PE=3 SV=1 CANONICAL=F1MTG3-1" }, "locus": { "chromosome": "28", "start_pos": 44157617, "end_pos": 44112989, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113177.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113177.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090389.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090389.1" } ] } }, { "isoform_ac": "A0AAA9SZK8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZK8/entry", "sequence": { "sequence": "MMNRTTPDQERAPASEPVWERPWSVEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIRETKATDCRLHNVFNEFLMLSNTQFIENRVYDEEVEEPVLKTEAEKPEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANERLELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIADSEEENEEEESDEDFANHSDNDQNRHIATMSDEEEDDDGCDIFADSEKEEEDVEDMEENSRPKRSRPTSFADELAARIKGDASSRMEGERTALSPGEAKPQKTLKEKKERKTPSDDEEDNLFAPPKLTDEDFSPFGSRGGLFSGGKGLFDDEDEESDLFAEAPQDRGARTPVNEASSSSKPGKKIPAGAVSVFLGDTDVFGATSAPAPREPQKHERPPPGKSAYVPASAGLFDDDDDDDDFFSASRSKPPKTDKVESTAGIFDDEEGDLFKERTVALPEATVNQTDGNKARAETKVMLPSSKNLKLSSETKTHKGLFSDEEDSEDLFSSQSVSKSKDASVLPSKHRSSVLLFDDEDGQDNLFDTPAAKKQTSSLPTQSQKKTKPSEPPKKKASALLFSSDEEDQWHVTDSQTNSTSDKSKGEPRDPEPTHQEVKAVKKTSLFEEDDEDDLFAIAKDSQKKAQRASLLFEDDADSGSSLFGSPPTSVPPATTKKETVPEVPPLLFSDEEEKAAQSGVKPAAKKAGSAKGTSELGRTPAVEESGKEGSLNVPTQETAKNSDLFSSSSPLDKGTKSRTKTVLSLFDEEEDKTEDQSSFQALRKEVGKSPDPGTRPKSTGVFQDEELLFSHKLQKDNDPDVDLFSGTKKSRLLEPSVGSLFGDDEDDDLFSSAKSQPLANLAINPAALLPPAAPQISGMKSVLPESGAPSSEPGRMQSLDRVPTPPGSGEAGVSFDLPAQADTLHCANKTRVKVRGKRRPQTRAARHLAAQESTEAEDVGSPRGFVAQLTDGATSPDGRQPPLRAAGGAEEAVAAATPTWAGGPVPGMNRGPFVKSVGQPLEDDLFDSGDIFSKGIASQSAGRKAKVKAASSLANLAEGSKDRSPMFPALGETGSDDDLFQSIKPKPAKKTNPFPFLEDEDDLFTDQRGKKNGSKSNSQQDIISKAQDIFEDDIFATEANKPSQKTREKERTFDSNLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDTDDIFSSGIQTKTTKSKSRSSQKVTESRSGQKVSNIFDDPLNAFGGQ", "length": 1271, "header": "tr|A0AAA9SZK8-1|F1MTG3_BOVIN Computationally mapped isoform of WASH complex subunit 2C OS=Bos taurus OX=9913 GN=WASHC2C PE=3 SV=1 CANONICAL=F1MTG3-1" }, "locus": { "chromosome": "28", "start_pos": 44157617, "end_pos": 44112989, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000107767.2", "url": "https://www.ensembl.org/id/ENSBTAT00000107767.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091902.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091902.1" } ] } }, { "isoform_ac": "A0AAA9U0B8-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U0B8/entry", "sequence": { "sequence": "MMNRTTPDQERAPASEPVWERPWSVEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIRETKATDCRLHNVFNEFLMLSNTQFIENRVYDEEVEEPVLKTEAEKPEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANERLELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIADSEEENEEEESDEDFANHSDNDQNRHIATMSDEEEDDDGCDIFADSEKEEEDVEDMEENSRPKRSRPTSFADELAARIKGDASSRMEGERTALSPGEAKPQKTLKEKKERKTPSDDEEDNLFAPPKLTDEDFSPFGSRGGLFSGGKGLFDDEDEESDLFAEAPQDRGARTPVNEASSSSKPGKKIPAGAVSVFLGDTDVFGATSAPAPREPQKHERPPPGKSAYVPASAGLFDDDDDDDDFFSASRSKPPKTDKVESTAGIFDDEEGDLFKERTVALPEATVNQTDGNKARAETKVMLPSSKNLKLSSETKTHKGLFSDEEDSEDLFSSQSVSKSKDASVLPSKHRSSVLLFDDEDGQDNLFDTPAAKKQTSSLPTQSQKKTKPSEPPKKKASALLFSSDEEDQWHVTDSQTNSTSDKSKGEPRDPEPTHQEVKAVKKTSLFEEDDEDDLFAIAKDSQKKAQRASLLFEDDADSGSSLFGSPPTSVPPATTKKETVPEVPPLLFSDEEEKAAQSGVKPAAKKAGSAKGTSELGRTPAVEESGKEGSLNVPTQETAKNSDLFSSSSPLDKGTKSRTKTVLSLFDEEEDKTEDQSSFQALRKEVGKSPDPGTRPKSTGVFQDEELLFSHKLQKDNDPDVDLFSGTKKSRLLEPSVGSLFGDDEDDDLFSSAKSQPLIPEKKKVVKKDNSISSVKNQKHPESTQGIKEKDVWKSETPQANLAINPAALLPPAAPQISGMKSVLPESGAPSSEPGRMQSLDRVPTPPGSGEAGVSFDLPAQADTLHCANKTRVKVRGKRRPQTRAARHLAAQESTEAEDVGSPRGFVAQLTDGATSPDGRQPPLRAAGGAEEAVAAATPTWAGGPVPGMNRGPFVKSVGQPLEDDLFDSGDIFSKGIASQSAGRKAKVKAASSLANLAEGSKDRSPMFPALGETGSDDDLFQSIKPKPAKKTNPFPFLEDEDDLFTDQRGKKNGSKSNSQQDIISKAQDIFEDDIFATEANKPSQKTREKERTFDSNLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDTDDIFSSGIQTKTTKSKSRSSQKVTESRSGQKVSNIFDDPLNAFGGQ", "length": 1312, "header": "tr|A0AAA9U0B8-1|F1MTG3_BOVIN Computationally mapped isoform of WASH complex subunit 2C OS=Bos taurus OX=9913 GN=WASHC2C PE=3 SV=1 CANONICAL=F1MTG3-1" }, "locus": { "chromosome": "28", "start_pos": 44157617, "end_pos": 44112989, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116982.2", "url": "https://www.ensembl.org/id/ENSBTAT00000116982.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103040.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103040.1" } ] } }, { "isoform_ac": "F1MTG3-1", "url": "https://www.uniprot.org/uniprotkb/F1MTG3/entry", "sequence": { "sequence": "MMNRTTPDQERAPASEPVWERPWSVEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIRETKATDCRLHNVFNEFLMLSNTQFIENRVYDEEVEEPVLKTEAEKPEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANERLELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIADSEEENEEEESDEDFANHSDNDQNRHIATMSDEEEDDDGCDIFADSEKEEEDVEDMEENSRPKRSRPTSFADELAARIKGDASSRMEGERTALSPGEAKPQKTLKEKKERKTPSDDEEDNLFAPPKLTDEDFSPFGSRGGLFSGGKGLFDDEDEESDLFAEAPQDRGARTPVNEASSSSKPGKKIPAGAVSVFLGDTDVFGATSAPAPREPQKHERPPPGKSAYVPASAGLFDDDDDDDDFFSASRSKPPKTDKVESTAGIFDDEEGDLFKERTVALPEATVNQTDGNKARAETKVMLPSSKNLKLSSETKTHKGLFSDEEDSEDLFSSQSVSKSKDASVLPSKHRSSVLLFDDEDGQDNLFDTPAAKKQTSSLPTQSQKKTKPSEPPKKKASALLFSSDEEDQWHVTDSQTNSTSDKSKGEPRDPEPTHQEVKAVKKTSLFEEDDEDDLFAIAKDSQKKAQRASLLFEDDADSGSSLFGSPPTSVPPATTKKETVPEVPPLLFSDEEEKAAQSGVKPAAKKAGSAKGTSELGRTPAVEESGKEGSLNVPTQETAKNSDLFSSSSPLDKGTKSRTKTVLSLFDEEEDKTEDQSSFQALRKEVGKSPDPGTRPKSTGVFQDEELLFSHKLQKDNDPDVDLFSGTKKSRLLEPSVGSLFGDDEDDDLFSSAKSQPLIPEKKKVVKKDNSISSVKNQKHPESTQGIKEKDVWKSETPQDSPGPAPLKTKEPSPRIWKIQANLAINPAALLPPAAPQISGMKSVLPESGAPSSEPGRMQSLDRVPTPPGSGEAGVSFDLPAQADTLHCANKTRVKVRGKRRPQTRAARHLAAQESTEAEDVGSPRGFVAQLTDGATSPDGRQPPLRAAGGAEEAVAAATPTWAGGPVPGMNRGPFVKSVGQPLEDDLFDSGDIFSKGIASQSAGRKAKVKAASSLANLAEGSKDRSPMFPALGETGSDDDLFQSIKPKPAKKTNPFPFLEDEDDLFTDQRGKKNGSKSNSQQDIISKAQDIFEDDIFATEANKPSQKTREKERTFDSNLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDTDDIFSSGIQTKTTKSKSRSSQKVTESRSGQKVSNIFDDPLNAFGGQ", "length": 1333, "header": "tr|F1MTG3-1|F1MTG3_BOVIN Isoform 1 of WASH complex subunit 2C OS=Bos taurus OX=9913 GN=WASHC2C PE=3 SV=2 CANONICAL=F1MTG3-1" }, "locus": { "chromosome": "28", "start_pos": 44157617, "end_pos": 44112989, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025173.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025173.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025173.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025173.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:513740", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:513740", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M9PU38-1", "protein_name": "WASH complex subunit 2 isoform X1", "gene_name": "washc2c", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSSFMENGPSNHNGEAEQVWERPWTLEEMQKSSTNWSLAADSGLFLFLRDFSQRMLSKTHEIEKQLDGLIRDTKATDSQLHTVFNDFLMLSNTQFIENRVYDEEVEDPTPKSETTERQPEQEKTREQKEAELIPKVQEAVNYGLKVLESAFEQLDIKAGNSDSEDEEVLEKVEPILEAKDLYVDRPLPYLIGSQAFMDQDDVGLGDLSSDEMSIGSDRDSVLESDVEDGDEHTDQDDYSDQDEEVQGNFKKKPSIASYNDADEENDDSDIFGGSDKDEDEDDLRKDTGVPSFADELAARIKGETQNKPEADRSSLSSGPSTTSKKSKTKKVPKPQVEDDQDEMFRPPTMEDEEYSPFGGKGGLFSGGKGLFDDDDEGDLFSEAPKNVPVEKEKTVAQPTVEPHKTKKIPTGAVSIFPGNSLLGSANDSESPKSSDSRSPALPKASIGGGLFDDDEDDDDFFSGKTQSKSTPGQDKKTPKKTVDLFGEADEEDEDEDDDTAMFSGKAISALPQQDISANGEEETRPPEKKPPAGAVSMFGPGTKNILEGLKKRRPSTSEESTKSEESGHAPEPVKSSPALGSAEKMQSKSLFSDDEDSQIFSSENTSKSKPTTQNKPSKAPLSIFDDEEEEDLFSSTPKPVPVKKTSLPPKNALSSSLFSDDEDQWMSSKSSKENPEVKPSGMKPSISAPSRLPSVKTTHKDGLFDDKDDEDLFAATNQSSKTSSQRVSLLFEDEDDEDKEPLFGFKTPAIKTPPESKTSGVSSLFESTEEDTGPSVVKEKITEEKKKPVESVPSSEDSFEVKKKPAGAVSLFGGIDILGDKQDTIKKPPKTQEEIPDDELQKEGPPPMESKGTKTKKTALSLFDEDDDDDDDDFSTDEIIPAPTASRSTEKNALKEHGPRMKSTGVFQDEELLFSQTQQRDNDPDVDLFATSPKPAVPPQSSAKSVAPTLFGDDDDDDLFSSAKPKAPPKVPEKPSKPKTNEIDKSISTSSKEPTNPLKSKKTSRIGELQAVLALNPAGLLPGAVPRAPGAVSVIPGLAHTGLPAAARTMPDHQGSSEGGVSFDSPALISTLLNANKGRAKGAGKRRPQTRAARHLAAQQSDEASGENVSVQKNEPAMAASLPPFNPVSVRPSALTIPVSAPAPAKSPDEAVRPKRFLEPTDDLFDSDDLFATKPVSSSKHKIQTTEEGQKKVSNTEDVTPSKKDQAPSIFDSHDEDLFATVKPKSVQKAKHMPFLDEGGEDSDEDIFGAGKSKSLESKNSKKEASAVKSDIFQDEVKEPPKAQKNPKEASLDASLFDDDVDIFADLTGTSKPKEKKAKKKVETKSIFDDDMDDIFSTGTTKPTVKPSSKSKKSQPIQEPASTAETAHNIFDDPLNAFGGN", "length": 1381 }, "evidence": [ { "id": "F1MTG3", "url": "https://omabrowser.org/oma/group/F1MTG3/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A1ZBW7-1", "protein_name": "WASH complex subunit 2", "gene_name": "FAM21", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDISADVDQIIAQAPDWTFAGDCALLALMKRISQNLEERGERTSRNLRDFETSVKQVDIALNNATTSLRSLQFGNQFVEYRVEEVDDADLAMPEEKKKKPELPLKSSEELAKEFLENNLRMFRKNYEPVTIEVPDSDDEDGPVHSTTVFRAKNPYDAIPLPYIIGTKEWQEHKYAGLYDSKENSEDDRSEEFSSSSSDEKEPETKKIATPANKLEEQHLSDSSSLASFAREPAIVSPVINPAVQVAEPVIRTQPRPIINSQRNPHERDMFAALRQSPPSDDPPSTSSSPTSSPAFRNPSSRLPIVSTASLSSSSSSPAQQPPRLFDEAVSTQTPKEAEIKPSQTKRMPVNLFNEDEFKSFMSEIVDKVQSKTPSSSVSPATTISTKEPPKTKKPVEEYPKPGPPKQIVEQTVPKRVNLFDDSPPLSPTPRSEPVFNNTKATGAIPKRSPVVVANNDEDNSLFGSSPAMPKENPSKKPPKPVTKSLFDDDLEDDDFLSSFTPKAKPPEQKLLSKPKPSLFDDDDLDIDDIFTKPSAQPKKLSERVAGKTSLFEDDDQDDVTDLFGSKKAKVIPKETSSGVSPNKNVETPVASKKSLFDDIEDEDLFGTPKAKNLIRSEPDNDPEAVGEDKKQSEIAEQKSKNIETGEKQHQVIAENASVPILRDSPPPMEVTEQKSDDKEWEAVKDDTSAANITKSKDLFSEDLTDDELFSSTSNNMAEPKSANETNEFNKPIEKYTSQTEENVSPVNPPTKLSIKPTDLFNEDFSDDDTFLSASMSKNEPLVGTENEDIKKPSEVQLVKEIKAEELPQQLPENKIYEITAVVEKDELVPEMLSKPQIDEPVSETPPPDDYQSNVDPIISMVADVTNKTSVDTLTPRKPADLAAAQQIMQNYSNLFSDEPPDDSEFFQTLGSSGLSSLSASKIFDNEHDFFEPALPNIPSATKPSPVTPGDQPSVSSDYGAMCLFSDVPPEDNDHAGEEVQKEAEPQKDELASTTRIHTIFYDDFSETARAGAVQPAPKRFPFDDEPPPADETDRSEVKETPELQKPTSPVKKLKMPNININVHALLPGSGSVPKLIRKQESSSSERDEPQATVQTEAEAPSSGQNTVSSADGVLQHVNKSRARGPAKRRPSTRRGRKENYAKSLLDAGQNEGPTASTRDSPEVEHSERSSIKAPSPQYVKPEKLFSTPAQQIQPQLQRPPPSNTGGSFLDSPDEDDSFFNSVPTKTVEGKQGTDPPKSYRSFLDSPDADDKLFSDLENNKAGINVVPVEKKPPKMANSFLASPDEDDFLFDSVKTNATTTAQKAFAAEIMNAFQKVTTAPPKPSNAKEAAKPKSQAAPKLFDDSDDDDDDLFARAPSIQTASKPVQAKQPPKPAATSLFSSDDEEAEVPVKSAPAKKLPVKPSKSLFSDDDDDDDLFGGSSTSKAAAAKKTKPAARTASKPPASKTTTPTATIPSNSGDNPLADLLDFK", "length": 1469 }, "evidence": [ { "id": "F1MTG3", "url": "https://omabrowser.org/oma/group/F1MTG3/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q552E2-1", "protein_name": "WASH complex subunit 2", "gene_name": "washc2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MPEEQPQQQQQPVREQPSNPDDVPWKKVWTINEMRDSAKDWNLSSDAGLLNYMQDFANKLIYKTKELEFQVDELVKDSKSIHVKVHNTFDQFLMLSNTQFIENRVYEDNSELNNEQNEQTDKPQQQEITEEILIPKFSKAILIGLEALEKANFVNAALEISEQSNSNNNNNDYQQQMNGSIAASSAEGGLVEGGEQAGTDAQPSANTEKKKEKLDHYLRYPLPHIIGSQQFHQDDFCGLFIEDSDSDSSDEEDEEDVDAEDGSDESSSESSSDDDDEKDEQQQSTLFLTDEQPKQQNFFFQDEDATSENNANKKVSESLFEDEDDIFGDKPVASKKSSNSYTSSLSDILGGDDEDDLFGGSKKKQQQQEDADGDEPTKKKDPFADELNNTLSSKNKGGDDDLFGGSSSTTTTSKPKKKSMFDDDLFGDSEETPAPKSSASRKVTFDDSLFGDDETALPTSKKDSTTTSSQPQQKKTLNDLFTDEDLTPATKKETKKSSSLSFLDGMDEDDLFGTPKPKSTTTSAAPTATTTKPPTPIPDSDASGSESTTGKSSPAPKKPVGGVKLFDFDAAGGDIFSGKKVGTGGKSSPSPAPKTESKASEDDFFSSDKKSTSATKKDAEIFGSEGGLLDVPEKKIKRHDPKKYVDSDVLGIDSISSDKNKPKVQDPFGVGAAGSNDDDSFDIPKANSKKEQETKPTKSTTTDDDLDIPKAPTTATTTTTTKPAVKKSTKSNFFDFEDTDSPLSSNKKSGGDDDLFSFDSSKTTTETKKQPITEEPKKKQDTTTTPSIDPFSGLDIKKPSEASISPASPVSTIESDPLFGDIKKPVAQKPKKTNFFDGDLTKDEPAKSEPTKVEPTKVEPTKAEPTKVEPAKVEPTKVESDKKESNPLGGGDEESVFGDFSIKKNPTTSSSTTATENKPAVKKSTKSNFFDFEDTDSPLSSNKKNDDDIFSSTTKKSTTTTTTTTSSKDFFGDLDTSSGNKKVEEKKSSDFDSFFSGSDDPLGITKPKSKTTTTPPLTSTTANIESDDPLSLGLPTFTNNNNNNNAKPPPPPSPLGEDVPSPLTSNNTKNRTKSIGSMFEAQQQLQQQQQEKNRSESPTSEKAEPTKKTSNISSLQNKLSLNPNMFLPGSKMPKKKKEESENEDDSSTNNDNDSSATDLSDSGRSSPSVTSPTLSGGRPRRNTVSSRNNNDSEESEPVKELTHATASRPKSGGRRPPTRKSGTSAPNRSESPTPTQKSDSESEKVRSSSPITTKPVVSEPTKKTISNTSFFDDIPSEKTSSGKSSPSPTIKSTSEKVTIDPLGDIFASTTTKPTASETKAALSSAPKKSEPETPKETPKETPKEKEQTKEKEQPKETPKTTTTKKSTKAVETKSETDSFFDDIPDIISRPKASVKSAAAKKASSTTKPVISDDIFDDITSTTSKSTTTTTTTTTTKAKSTKAVDNLFDDDTNTTTKATPTKATPSKSKPKAKNVENLFD", "length": 1479 }, "evidence": [ { "id": "F1MTG3", "url": "https://omabrowser.org/oma/group/F1MTG3/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q641Q2-1", "protein_name": "WASH complex subunit 2A", "gene_name": "WASHC2A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMNRTTPDQELAPASEPVWERPWSVEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIRETKATDCRLHNVFNDFLMLSNTQFIENRVYDEEVEEPVLKAEAEKTEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANGRVELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDTEEEKEEEESDEDFAHHSDNEQNRHTTQMSDEEEDDDGCDLFADSEKEEEDIEDIEENTRPKRSRPTSFADELAARIKGDAVGRVDEEPTTLPSGEAKPRKTLKEKKERRTPSDDEEDNLFAPPKLTDEDFSPFGSGGGLFSGGKGLFDDEDEESDLFTEAPQDRQAGASVKEESSSSKPGKKIPAGAVSVFLGDTDVFGAASVPSMKEPQKPEQPTPRKSPYGPPPTGLFDDDDGDDDDDFFSAPHSKPSKTGKVQSTADIFGDEEGDLFKEKAVASPEATVSQTDENKARAEKKVTLSSSKNLKPSSETKTQKGLFSDEEDSEDLFSSQSASKLKGASLLPGKLPTLVSLFDDEDEEDNLFGGTAAKKQTLCLQAQREEKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEEDEEDDLFAIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAQLGVKSVDKKVESAKESLKFGRTDVAESEKEGLLTRSAQETVKHSDLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNIIQAPQKEVGKGRDPDAHPKSTGVFQDEELLFSHKLQKDNDPDVDLFAGTKKTKLLEPSVGSLFGDDEDDDLFSSAKSQPLVQEKKRVVKKDHSVDSFKNQKHPESIQGSKEKGIWKPETPQDSSGLAPFKTKEPSTRIGKIQANLAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQADTLHSANKSRVKMRGKRRPQTRAARRLAAQESSETEDMSVPRGPIAQWADGAISPNGHRPQLRAASGEDSTEEALAAAAAPWEGGPVPGVDRSPFAKSLGHSRGEADLFDSGDIFSTGTGSQSVERTKPKAKIAENPANPPVGGKAKSPMFPALGEASSDDDLFQSAKPKPAKKTNPFPLLEDEDDLFTDQKVKKNETKSNSQQDVILTTQDIFEDDIFATEAIKPSQKTREKEKTLESNLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDMDDIFSSGIQAKTTKPKSRSAQAAPEPRFEHKVSNIFDDPLNAFGGQ", "length": 1341 }, "evidence": [ { "id": "F1MTG3", "url": "https://omabrowser.org/oma/group/F1MTG3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6PGL7-1", "protein_name": "WASH complex subunit 2", "gene_name": "Washc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNRTSPDSERPPASEPVWERPWSVEEIRRSSQNWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIQETKATHCRLHNVFNDFLMLSNTQFIENRVYDEEVEEQVLKAEAEKAEQEKTREQKEIDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANERVDLILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDSEDEKEEEESDEDFASHSDNDQNQHTTQISDEEEDDDGDLFADSEKEGDDIEDIEESAKSKRPTSFADELAARIKGDISNQRKEGQTDGKPQKTVKEKKERRTPADDEEDILFPPPTLTDEDFSPFGSRGGLFSNGQGLFDDEDESDLFKEAPRARPAQAPVSEELPPSPKPGKKIPAGAVSVLLGHPDVSGSTSAPSLKELQKHGQPTPGKSSHLPTPAGLFDDDDNDNDEDDNNFFMPSSSKPSKTDKVKSTAIIFDDDEGDLFKEKAEALPAASVSQTHESKTRADKTIALPSSKNLKLVSETKTQKGLFSDEEDSEDLFSSQSSSKPKSASLPSSQPPTSVSLFGDEDEEDSLFGSAAAKKQTSSLQPQSQEKAKPSEQPSKKTSALLFSSDEEDQWNIADSHTKLASDNKSKGELWDSGATQGQEAKAVKKTNLFEDDDDDEVDLFAIAKDSQKKTQRTSLLFEDDAESGSSLFGLPPTSVPSATTKKESVPKVPLLFSDEEDSEVPSGVKPEDLKVDNARVSPEVGSADVASIAQKEGLLPASDQEAGGPSDIFSSSSPLDKGAKGRTRTVLSLFDEDEDKVEDESSTCAPQDGREKGLKTDSRPKSTGVFQDEELLFSHKLQKDNDPDVDLFAGTKKIRSSVPSGGSLFGDDEDDDLFSSAKTQPVVPEKKGTLKKDHPVSLKNQDPLDSTQGSKEKSTWKTEPAQDSSGLTPFKSREPSSRIGKIQANLAINPAALLPTVALQIPGTKPVSSELAFPSSEPGRSHILESVPTLPGSVEAGVSFDLPAQADTLHSANKSRVKVRGKRRPQTRAARRLAAQESSEAEDVTVDRGPVAQLSSSPVLPNGHQPLLQPRMASGQTSSETATAPPWEGGPVLSAADRSFFVKSRPQTGNEADLFDSGDIFPKSRGSQSVEGAGVMAGEPPSHSSGGRKEKSLAFPDLSEGSSTEDLFQSVKPRAAKNRNPFPLLEDEEDLFADPRGKKNERKPDSHQDSVSKTHDIFEDDIFATEAIKPFPKKREKGRTLEPNLFDDNIDIFADLTVKPKEKSKKKVAAKSMFDDDTDDIFSSGLQAKASKPKSQSAEAASEQRSEHKVASIFDDPLNAFGSQ", "length": 1334 }, "evidence": [ { "id": "F1MTG3", "url": "https://omabrowser.org/oma/group/F1MTG3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q80X08-1", "protein_name": "WASH complex subunit 2", "gene_name": "Washc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNRTSPDSEQPPASEPVWERPWSVEEIRRSSQNWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIQETKATHCRLHNVFNDFLMLSNTQFIENRVYDEEVEDQALKTEAEKAEQEKTREQKEIDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEEDANERVELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDSEDEKEEEESDDFASHSDNEQNQHITQMSDEEEDDDADLFADSEKEGDDIEDIEESAKSKRPTSFADELAARIKGDVSNQRKEGHTDGKPQRTVKEKKERRTPADDEEDILFPPPTLTDEDFSPFGSRGGLFSDRQGLFDDDDESDLFKEAPRGQPAQGPVSEESPPSPKPGKKIPAGAVSVFLGYTDVSGSTSAPSLKEFQKHEQSTPGKSPHLPAPTGLFDDDDNDSDEDDNFFMPSSSKPSKTDKVKPTTIIFDDDEGDLFKEKTTALPAASVSQTDENKARTDKTITLPSSKNPKLVSETKTQKGLFSDEEDSEDLFSSQSSSKTKSASVLSSQPPASVSLFGDEDEEDNLFGSAAAKKQTSSLPPQSQEKAKPSEQPPKKASALFSSDEEDQWSVADSQTKLASERKSKGERWDAGTNQGQEAKAVKKTNLFEEEDDDGVDLFAIAKDSQKKTQRTSLLFEDDTDSGSSLFSLPPTSVPPAATKKESIPKVPLLFSDEEDSEVPSGVKPVDLKAENAAASPEVGSADVANVAQKEGLLPTSDQEAGGPSDIFSSSSPLDKGAKGRTKTVLSLFDEDEDKVEDDSNTCAPQGGLEKGVKTDRRPKSTGVFQDEELLFSHKLQKDNDPDVDLFAGTKKTRLSMPSGGSLFGDDDDDDLFSTAKTQPAQPVVPEKKGTLRKDHKPPELTEGSKEKSTWKAETAQDSSGLTPFKSREPSSRIGKIQANLAINPATLLPSVAPQIPGAKPASCELAFPSSEPARSHIREAVPTLPGSEEAGVSFDLPAQADTLHSANKGRVKVRGKRRPQTRAARRLAAQESSEAEDVTIDRGPVTQLSSSPVLPNGHQPLLQPRMASGETSSEKAMAVPWEGGPVLSAVDRSFFVKSLPQTGNEAHLFDSGDIFPKSTGSQSMEGASVKAGETPAHSSAGRKEKSLVFPDLSEASGVDDLFQSAKPRPTKKRNPFPLLEDEEDLFADQKGKKNQWKSDSHQDVVSKTQDIFEDDIFATEAIKKPFPKKREKERTLEPNLFDDNIDIFADLTVKPKEKPKKKVTAKSMFDDDTDDIFSSGLQAKASKPKSQSAEAVSELRSENKVSNIFDDPLNAFGSQ", "length": 1328 }, "evidence": [ { "id": "F1MTG3", "url": "https://omabrowser.org/oma/group/F1MTG3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MTG3", "url": "https://www.uniprot.org/uniprotkb/F1MTG3" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "F1MTG3", "url": "https://www.uniprot.org/uniprotkb/F1MTG3" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "F1MTG3", "url": "https://www.uniprot.org/uniprotkb/F1MTG3" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MTG3", "url": "https://www.uniprot.org/uniprotkb/F1MTG3" } ], "pmid": "" }, { "name": "WASH complex", "id": "GO:0071203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071203", "evidence": [ { "database": "UniProtKB", "id": "F1MTG3", "url": "https://www.uniprot.org/uniprotkb/F1MTG3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein localization to endosome", "id": "GO:0036010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036010", "evidence": [ { "database": "UniProtKB", "id": "F1MTG3", "url": "https://www.uniprot.org/uniprotkb/F1MTG3" } ], "pmid": "" }, { "name": "retrograde transport, endosome to Golgi", "id": "GO:0042147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042147", "evidence": [ { "database": "UniProtKB", "id": "F1MTG3", "url": "https://www.uniprot.org/uniprotkb/F1MTG3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphatidylinositol phosphate binding", "id": "GO:1901981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901981", "evidence": [ { "database": "UniProtKB", "id": "F1MTG3", "url": "https://www.uniprot.org/uniprotkb/F1MTG3" } ], "pmid": "" }, { "name": "retromer complex binding", "id": "GO:1905394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905394", "evidence": [ { "database": "UniProtKB", "id": "F1MTG3", "url": "https://www.uniprot.org/uniprotkb/F1MTG3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1025, "end_pos": 1027, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1209, "end_pos": 1211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 236, "end_pos": 238, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3, "end_pos": 5, "annotation": "n_glycosylation_sequon" }, { "start_pos": 502, "end_pos": 504, "annotation": "n_glycosylation_sequon" }, { "start_pos": 632, "end_pos": 634, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MTG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MTG3" }, { "id": "PF15255", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF15255" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FAM21/CAPZIP", "eco_id": "ECO_0000259", "start_pos": 940, "end_pos": 1076, "start_aa": "Ala", "end_aa": "Arg", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1025, "end_pos": 1027 }, { "start_pos": 1209, "end_pos": 1211 }, { "start_pos": 236, "end_pos": 238 }, { "start_pos": 3, "end_pos": 5 }, { "start_pos": 502, "end_pos": 504 }, { "start_pos": 632, "end_pos": 634 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MN32-1", "uniprot_ac": "F1MN32", "uniprot_id": "F1MN32_BOVIN", "mass": { "chemical_mass": 74794.0, "monoisotopic_mass": 74794.0 }, "refseq": {}, "gene_names": [ { "name": "ITPKC", "type": "recommended", "evidence": [ { "id": "F1MN32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN32" } ] } ], "protein_names": [ { "name": "Kinase", "type": "recommended", "evidence": [ { "id": "F1MN32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN32/entry#names_and_taxonomy" } ] }, { "name": "2.7.-.-", "type": "synonym", "evidence": [ { "id": "F1MN32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN32/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MN32", "url": "https://www.uniprot.org/uniprotkb/F1MN32" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ITPKC", "url": "https://www.uniprot.org/uniprotkb/F1MN32", "locus": { "chromosome": "18", "start_pos": 50013372, "end_pos": 49995822, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019465", "url": "https://www.ensembl.org/id/ENSBTAG00000019465" } ] } } ], "crossref": [ { "id": "F1MN32", "url": "https://alphafold.ebi.ac.uk/entry/F1MN32", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019465", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019465", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR005522", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005522", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038286", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038286", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "WADNLWT", "url": "https://omabrowser.org/oma/group/WADNLWT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MN32", "url": "https://www.orthodb.org/?gene=F1MN32", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12400", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12400", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12400:SF106", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12400:SF106", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03770", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03770", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1855204", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855204", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "11020", "url": "https://www.rhea-db.org/rhea/11020", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SRZ7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SRZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN32", "url": "https://www.uniprot.org/uniprotkb/F1MN32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MN32-1", "url": "https://www.uniprot.org/uniprotkb/F1MN32-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRRCPCRGSLSEAEAQALPAAARMGLAAPRGGRRRQPGQQRPGPGAGGPVGRPEGGGPRARTEESNRHTEPERASLGLESGADGRAEPEAAGLGAETERPNPTTEPGKSILRTHLGGSSHWSELETAGDWTETGTDGFWADPHRTDLQSQPQRTNLWAQPGVDGPWTELEKYGSQTQSERAKPRADNLCTQNRSSVRTQPEGVPLSTERSADSSWKQPFTEGSRTQKGTEDSWTELHTDGSQIQQDTETAWKQLDPGGFPTQDTDGLWSQPGTDGSQTEPRTDCLLGEPNQDDSLEEPEHRELVTHLYSHLEGSTLTPVPRLIITPETPEPEARPGGPPSQLEAGSGGFSSASSFDESEDDVVAGGGGASDPEDRSGNKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHSGNFQAGEDGWILKRFCQYEQRSLEQLMRDPLRPFVPAYYGVVQRDGQTFNQMEDLLADFENPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQCAVTKPRYMQWRETVSSTSTLGFRIEGIKKADGTCNTNFKKTQKLEQVTKVLEDFVDGNHTILRKYVARLEELREALESSPFFRTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWVEGNREDGYLWGLDNMICLLQGLAQS", "length": 675, "header": "tr|F1MN32-1|F1MN32_BOVIN Isoform 1 of Kinase OS=Bos taurus OX=9913 GN=ITPKC PE=3 SV=3 CANONICAL=F1MN32-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SRZ7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SRZ7/entry", "sequence": { "sequence": "MRRCPCRGSLSEAEAQALPAAARMGLAAPRGGRRRQPGQQRPGPGAGGPVGRPEGGGPRARTEESNRHTEPERASLGLESGADGRAEPEAAGLGAETERPNPTTEPGKSILRTHLGGSSHWSELETAGDWTETGTDGFWADPHRTDLQSQPQRTNLWAQPGVDGPWTELEKYGSQTQSERAKPRADNLCTQNRSSVRTQPEGVPLSTERSADSSWKQPFTEGSRTQKGTEDSWTELHTDGSQIQQDTETAWKQLDPGGFPTQDTDGLWSQPGTDGSQTEPRTDCLLGEPNQDDSLEEPEHRELVTHLYSHLEGSTLTPVPRLIITPETPEPEARPGGPPSQLEAGSGGFSSASSFDESEDDVVAGGGGASDPEDRSGNKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHSGNFQAGEDGWILKRFCQYEQRSLEQLMRDPLRPFVPAYYGVVQRDGQTFNQMEDLLADFENPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQCAVTKPRYMQWRETVSSTSTLGFRIEGIKKADGTCNTNFKKTQKLEQVTKVLEDFVDGNHTILVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWVEGNREDGYLWGLDNMICLLQGLAQS", "length": 651, "header": "tr|A0AAA9SRZ7-1|F1MN32_BOVIN Computationally mapped isoform of Kinase OS=Bos taurus OX=9913 GN=ITPKC PE=3 SV=1 CANONICAL=F1MN32-1" }, "locus": { "chromosome": "18", "start_pos": 50012113, "end_pos": 49995835, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116732.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116732.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000086731.1", "url": "https://www.ensembl.org/id/ENSBTAP00000086731.1" } ] } }, { "isoform_ac": "F1MN32-1", "url": "https://www.uniprot.org/uniprotkb/F1MN32/entry", "sequence": { "sequence": "MRRCPCRGSLSEAEAQALPAAARMGLAAPRGGRRRQPGQQRPGPGAGGPVGRPEGGGPRARTEESNRHTEPERASLGLESGADGRAEPEAAGLGAETERPNPTTEPGKSILRTHLGGSSHWSELETAGDWTETGTDGFWADPHRTDLQSQPQRTNLWAQPGVDGPWTELEKYGSQTQSERAKPRADNLCTQNRSSVRTQPEGVPLSTERSADSSWKQPFTEGSRTQKGTEDSWTELHTDGSQIQQDTETAWKQLDPGGFPTQDTDGLWSQPGTDGSQTEPRTDCLLGEPNQDDSLEEPEHRELVTHLYSHLEGSTLTPVPRLIITPETPEPEARPGGPPSQLEAGSGGFSSASSFDESEDDVVAGGGGASDPEDRSGNKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHSGNFQAGEDGWILKRFCQYEQRSLEQLMRDPLRPFVPAYYGVVQRDGQTFNQMEDLLADFENPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQCAVTKPRYMQWRETVSSTSTLGFRIEGIKKADGTCNTNFKKTQKLEQVTKVLEDFVDGNHTILRKYVARLEELREALESSPFFRTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWVEGNREDGYLWGLDNMICLLQGLAQS", "length": 675, "header": "tr|F1MN32-1|F1MN32_BOVIN Isoform 1 of Kinase OS=Bos taurus OX=9913 GN=ITPKC PE=3 SV=3 CANONICAL=F1MN32-1" }, "locus": { "chromosome": "18", "start_pos": 50012113, "end_pos": 49995835, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025930.6", "url": "https://www.ensembl.org/id/ENSBTAT00000025930.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025930.5", "url": "https://www.ensembl.org/id/ENSBTAP00000025930.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 515, "start_aa": "Thr", "end_pos": 515, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr515", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-1855204", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855204", "resource": "Reactome", "description": "Synthesis of IP3 and IP4 in the cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "Q7TS72-1", "protein_name": "Inositol-trisphosphate 3-kinase C", "gene_name": "Itpkc", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRRCPCRGSLSEAEAGALPAEARMGLEALRGGRRRQPGLQRPGPGAGGPTGRPEGGGPRAWIEESSLHSEAERTDLEPAPCPNGPQAESCGDGHAECEAAGLVVASEKPRQNKELDGSNLQTHPRRNSPLVEMEMAGSWTDGFRTDLHRSDLQSRPKRASLCTQPGFDESWTELDRSDMWQTLPERDNKPRVDNLRTHHGVSKLQTHPVCLSPESSADNSGKELSADASRTPHDTDGFWIESQTDDSLKGPSTQTACRQPGSDGFSSKDTESALTQPGTDGLRDDSVLGESNGNDPLDLSEPGELVTNLCSHLECSSLCPVPRLIITPETPEPEAQPVGPQSRIEGGTGGFSSASSFDESEDDLVAGGGGTSDPEDRAGSKPWKKLKTVLKYSPFVVSFHKHYYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLELLMGDPLRPFVPAYYGMVQRDGQAFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPKPRKDMYEKMVAVDPGAPTPEEHAQGAITKPRYMQWRETLSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVNGDLGILRKYVARLEDLRETLENSPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQMLSHRLPWTEGNREDGYLWGLDNLICLLQGLAQS", "length": 678 }, "evidence": [ { "id": "F1MN32", "url": "https://omabrowser.org/oma/group/F1MN32/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q80ZG2-1", "protein_name": "Inositol-trisphosphate 3-kinase C", "gene_name": "Itpkc", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRRCPCRGSLSEAEAGALPAEARMGLEALRGGRRRQPGLQRPGPGAGGPTGRPEGGGPRAWIEGFSLHSEAERTDFGPAPCPDGPQAEPCGDEHEECEAAGLGVASEKPSQNKELDGSNLQTHPKLSSPLAEMEMAGSWTDGFRTDLHRPDLQARPKRASLCTQPGFDESWTELDRSELWQTLPERDKPWVDHLRTHQDMSRLQNHPACPSPEPSAGTSCKELSADGSRTPHDTDGFWIESQTDGSLIGPSTQTACRQPANDGFSAQDTDGTLIQPGTDDGPWVDSVLEKSNGDDPLMEPEPRDLVTNLCSHLECSSLCPVPRLIITSESPEPGAQPLGPQARIEGGTGGFSSASSFDESEDDLVAGGGGTSDPEDRSGSKPWKKLKTVLKYSPFVVSFHKHYYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLELLMGDPLRPFVPTYYGMVQRDGQAFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPKPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETLSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVNGDVGILRKYVARLEDLRDTLENSPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQMLSHRLPWAEGNREDGYLWGLDNLICLLQGLAQS", "length": 678 }, "evidence": [ { "id": "F1MN32", "url": "https://omabrowser.org/oma/group/F1MN32/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96DU7-1", "protein_name": "Inositol-trisphosphate 3-kinase C", "gene_name": "ITPKC", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRRCPCRGSLNEAEAGALPAAARMGLEAPRGGRRRQPGQQRPGPGAGAPAGRPEGGGPWARTEGSSLHSEPERAGLGPAPGTESPQAEFWTDGQTEPAAAGLGVETERPKQKTEPDRSSLRTHLEWSWSELETTCLWTETGTDGLWTDPHRSDLQFQPEEASPWTQPGVHGPWTELETHGSQTQPERVKSWADNLWTHQNSSSLQTHPEGACPSKEPSADGSWKELYTDGSRTQQDIEGPWTEPYTDGSQKKQDTEAARKQPGTGGFQIQQDTDGSWTQPSTDGSQTAPGTDCLLGEPEDGPLEEPEPGELLTHLYSHLKCSPLCPVPRLIITPETPEPEAQPVGPPSRVEGGSGGFSSASSFDESEDDVVAGGGGASDPEDRSGSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEGNREDGYLWGLDNMICLLQGLAQS", "length": 683 }, "evidence": [ { "id": "F1MN32", "url": "https://omabrowser.org/oma/group/F1MN32/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "kinase activity", "id": "GO:0016301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016301", "evidence": [ { "database": "UniProtKB", "id": "F1MN32", "url": "https://www.uniprot.org/uniprotkb/F1MN32" } ], "pmid": "" }, { "name": "inositol hexakisphosphate kinase activity", "id": "GO:0000828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000828", "evidence": [ { "database": "UniProtKB", "id": "F1MN32", "url": "https://www.uniprot.org/uniprotkb/F1MN32" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MN32", "url": "https://www.uniprot.org/uniprotkb/F1MN32" } ], "pmid": "" }, { "name": "inositol-1,4,5-trisphosphate 3-kinase activity", "id": "GO:0008440", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008440", "evidence": [ { "database": "UniProtKB", "id": "F1MN32", "url": "https://www.uniprot.org/uniprotkb/F1MN32" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "inositol phosphate biosynthetic process", "id": "GO:0032958", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032958", "evidence": [ { "database": "UniProtKB", "id": "F1MN32", "url": "https://www.uniprot.org/uniprotkb/F1MN32" } ], "pmid": "" }, { "name": "cellular response to calcium ion", "id": "GO:0071277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071277", "evidence": [ { "database": "UniProtKB", "id": "F1MN32", "url": "https://www.uniprot.org/uniprotkb/F1MN32" } ], "pmid": "" }, { "name": "phosphatidylinositol phosphate biosynthetic process", "id": "GO:0046854", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046854", "evidence": [ { "database": "UniProtKB", "id": "F1MN32", "url": "https://www.uniprot.org/uniprotkb/F1MN32" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MN32", "url": "https://www.uniprot.org/uniprotkb/F1MN32" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MN32", "url": "https://www.uniprot.org/uniprotkb/F1MN32" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1MN32", "url": "https://www.uniprot.org/uniprotkb/F1MN32" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 580, "end_pos": 582, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11020", "name": "", "equation": "1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LNH2-1", "F1MN32-1" ], "evidence": [ { "id": "11020", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11020" } ] }, { "id": "R-BTA-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-114520" ], "output_participant_list": [], "enzyme_list": [ "A0A3Q1LNH2-1", "F1MN32-1" ], "evidence": [ { "id": "R-BTA-1855153", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1855153" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-114520", "participant_name": "I(1,4,5)P3 [cytosol]", "crossref": [ { "id": "203600", "database": "ChEBI", "url": "" }, { "id": "ZINC000004095598", "database": "ZINC", "url": "" }, { "id": "C01245", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LNH2", "gene_name": "ITPKB", "activity": [ { "ec_number": "2.7.-.-", "activity": "", "evidence": [ { "id": "A0A3Q1LNH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNH2" } ] } ] }, { "uniprot_ac": "F1MN32", "gene_name": "ITPKC", "activity": [ { "ec_number": "2.7.-.-", "activity": "", "evidence": [ { "id": "F1MN32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN32" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MN32-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 675, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MN32-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MN32" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 515 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 192, "end_pos": 194 }, { "start_pos": 580, "end_pos": 582 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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"sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MSX4-1", "uniprot_ac": "F1MSX4", "uniprot_id": "F1MSX4_BOVIN", "mass": { "chemical_mass": 69685.0, "monoisotopic_mass": 69685.0 }, "refseq": { "ac": "XP_002685278", "name": "mitogen-activated protein kinase kinase kinase 2 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685278" }, "gene_names": [ { "name": "MAP3K2", "type": "recommended", 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"database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06652", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06652", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "504592", "url": "https://www.ncbi.nlm.nih.gov/gene/504592", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000270", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000270", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053793", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053793", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:504592", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504592", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GPTNRDR", "url": "https://omabrowser.org/oma/group/GPTNRDR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MSX4", "url": "https://www.orthodb.org/?gene=F1MSX4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11584", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11584", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11584:SF369", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11584:SF369", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00069", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00564", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00564", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002685278", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685278", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9SSF1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SSF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSX4", "url": "https://www.uniprot.org/uniprotkb/F1MSX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MSX4-1", "url": "https://www.uniprot.org/uniprotkb/F1MSX4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMDDQQALNSIMQDLAVLHKASRPALSLQETRKTKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSAQATNLEPLPSLEDLDNTVFGAERKKGLSVVGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHISYHHQDYNDGRKTFPRARRTQGTSFRSPVSFSPTDHSLSTSSGSSIFTPEYDESRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPPADDLLRHTFVHCH", "length": 620, "header": "tr|F1MSX4-1|F1MSX4_BOVIN Isoform 1 of mitogen-activated protein kinase kinase kinase OS=Bos taurus OX=9913 GN=MAP3K2 PE=3 SV=2 CANONICAL=F1MSX4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SSF1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SSF1/entry", "sequence": { "sequence": "MMDDQQALNSIMQDLAVLHKASRPALSLQETRKTKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSAQATNLEPLPSLEDLDNTVFGAERKKGLSVVGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHISYHHQDYNDGRKTFPRARRTQGTSFRSPVSFSPTDHSLSTSSGSSIFTPEYDESRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPPADDLLRHTFVHCH", "length": 591, "header": "tr|A0AAA9SSF1-1|F1MSX4_BOVIN Computationally mapped isoform of mitogen-activated protein kinase kinase kinase OS=Bos taurus OX=9913 GN=MAP3K2 PE=3 SV=1 CANONICAL=F1MSX4-1" }, "locus": { "chromosome": "2", "start_pos": 5233999, "end_pos": 5199419, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104303.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104303.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000089315.1", "url": "https://www.ensembl.org/id/ENSBTAP00000089315.1" } ] } }, { "isoform_ac": "F1MSX4-1", "url": "https://www.uniprot.org/uniprotkb/F1MSX4/entry", "sequence": { "sequence": "MMDDQQALNSIMQDLAVLHKASRPALSLQETRKTKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSAQATNLEPLPSLEDLDNTVFGAERKKGLSVVGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHISYHHQDYNDGRKTFPRARRTQGTSFRSPVSFSPTDHSLSTSSGSSIFTPEYDESRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPPADDLLRHTFVHCH", "length": 620, "header": "tr|F1MSX4-1|F1MSX4_BOVIN Isoform 1 of mitogen-activated protein kinase kinase kinase OS=Bos taurus OX=9913 GN=MAP3K2 PE=3 SV=2 CANONICAL=F1MSX4-1" }, "locus": { "chromosome": "2", "start_pos": 5233999, "end_pos": 5199419, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000005525.6", "url": "https://www.ensembl.org/id/ENSBTAT00000005525.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000005525.5", "url": "https://www.ensembl.org/id/ENSBTAP00000005525.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 159, "start_aa": "Thr", "end_pos": 159, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr159", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:504592", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504592", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZJ31-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 2", "gene_name": "MAP3K2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDEQQALNSIMQDLAVLHKASRPALPQQETGKPKSSSPKKQNDVRVKFEHRGEKRILQLPRPVKLEDLVAKAKVAFGQTMDLHYCNNELVIPLTTQDDLDKAVELLDRSVHMKSLKILLVIHGNTQSPSVNNVEPLPSLEDLDNTVFGVTERKRRLSVIGSNNRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGDNYPKSRMPRAQSYPDNHQEFSVEYDIPIFEKFGKGGTYPRRYHISYHQQDYNDGRKTFPRARRTQGNSFRSPVSFSPTDHSLSTSSGSSVFTPEYEDNRMRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGFLRDPPERTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVLYLHTNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPPHVSDHARDFLKRIFIEAKLRPFADELLRHTFAHYH", "length": 624 }, "evidence": [ { "id": "F1MSX4", "url": "https://omabrowser.org/oma/group/F1MSX4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E7F683-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 2", "gene_name": "map3k2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDEQEALNSIMQDLAVLHRSSRPSVLSDLAKPKASSPKNQNDVRVKFEYRGEKRILQFPRPVSLEDLSAKAKVAFGQSMDLHYTNNELVIPLSTQDDLDKAVELLDRSVHMKSLKILLVLPSWSQNCVSSKDLLPTHDILDNTDFSAPDKKSMLAHIGSQSTDRSSPPPGYIPDALQQVARNGSFTSINSEGEFIPESMDQMLDPLSMSSPENSASGSCPSLDSPLDSDTYPKSRMPRALSYPDNHQEFPEYDIPVFEKTGKGGTYPRRYHIPFGLQDYSDGRKTFPRARRTQAHGFRSPVSFSPTEQQSPSTSSGSSIFTPELEEPGRRRRGSDIEPSSNPTLSVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALECEIQLLKNLFHERIVQYYGCLRDTHEKTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEGVCYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASRRLQTICLSGTGIKSVTGTPYWMSPEVISGEGYGRKADIWSIGCTVVEMLTQRPPWAEFEAMAAIFKIATQPTNPTLPPHVSDHCRDFLKRIFVETKQRPAAEDLLRHTFVH", "length": 623 }, "evidence": [ { "id": "F1MSX4", "url": "https://omabrowser.org/oma/group/F1MSX4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1M9D0-1", "protein_name": "mitogen-activated protein kinase kinase kinase", "gene_name": "Map3k2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKPSSPKKQNDVRVKFEHRGEKRILQVTRPVKLEDLRSKSKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVLNGSTQATNLEPSPSPDDLNNTPLGAERKKRLSVVGPPNRDRSSPPPGYIPDELHQIARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSFRSPVSFSPTDHSLSTSSGSSIFTPEYEDSRIRRRGSDIDNPTLTVTDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSAEELLRHLFVHCH", "length": 619 }, "evidence": [ { "id": "F1MSX4", "url": "https://omabrowser.org/oma/group/F1MSX4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61083-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 2", "gene_name": "Map3k2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKPSSPKKQNDVRVKFEHRGEKRILQVTRPVKLEDLRSKSKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVVNGSTQATNLEPSPSPEDLNNTPLGAERKKRLSVVGPPNRDRSSPPPGYIPDILHQIARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFTDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSFRSPVSFSPTDHSLSTSSGSSVFTPEYDDSRIRRRGSDIDNPTLTVTDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMELSPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSAEELLRHMFVHYH", "length": 619 }, "evidence": [ { "id": "F1MSX4", "url": "https://omabrowser.org/oma/group/F1MSX4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y2U5-1", "protein_name": "Mitogen-activated protein kinase kinase kinase 2", "gene_name": "MAP3K2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFPRPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVINGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFVHYH", "length": 619 }, "evidence": [ { "id": "F1MSX4", "url": "https://omabrowser.org/oma/group/F1MSX4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "F1MSX4", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MSX4", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "F1MSX4", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MSX4", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ], "pmid": "" }, { "name": "MAP kinase kinase kinase activity", "id": "GO:0004709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004709", "evidence": [ { "database": "UniProtKB", "id": "F1MSX4", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "F1MSX4", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ], "pmid": "" }, { "name": "MAPK cascade", "id": "GO:0000165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000165", "evidence": [ { "database": "UniProtKB", "id": "F1MSX4", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ], "pmid": "" }, { "name": "cellular response to mechanical stimulus", "id": "GO:0071260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "evidence": [ { "database": "UniProtKB", "id": "F1MSX4", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MSX4", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MSX4", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 181, "end_pos": 183, "annotation": "n_glycosylation_sequon" }, { "start_pos": 459, "end_pos": 461, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + 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"id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1N9F5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": 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"ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] } ] }, { "uniprot_ac": "A0AAA9RVB1", "gene_name": "TAOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RVB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RVB1" } ] } ] }, { "uniprot_ac": "A0AAA9RW51", "gene_name": "AATK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] } ] }, { "uniprot_ac": "A0AAA9S2N3", "gene_name": "CDKL4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9S2N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S2N3" } ] } ] }, { "uniprot_ac": "A0AAA9S472", "gene_name": "MAPK8", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9S472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S472" } ] } ] }, { "uniprot_ac": "A0AAA9S4Z4", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S4Z4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S4Z4" } ] } ] }, { "uniprot_ac": "A0AAA9S5X7", "gene_name": "AURKB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S5X7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S5X7" } ] } ] }, { "uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08E52" } ] } ] }, { "uniprot_ac": "Q0V7M1", "gene_name": "PSKH1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0V7M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0V7M1" } ] } ] }, { "uniprot_ac": "Q0VD22", "gene_name": "STK33", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", 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"L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "V6F977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/V6F977" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MSX4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 620, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MSX4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MSX4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" }, { "id": "PS51745", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51745" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PB1", "eco_id": "ECO_0000259", "start_pos": 44, "end_pos": 123, "start_aa": "Asp", "end_aa": "Asn", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" }, { "id": "PS50011", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50011" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Protein kinase", "eco_id": "ECO_0000259", "start_pos": 357, "end_pos": 617, "start_aa": "Trp", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "2.7.11.25", "ec_name": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "2.7.11.25", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25" }, { "id": "2.7.11.25", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.11.25" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 159 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 123, "end_pos": 125 }, { "start_pos": 181, "end_pos": 183 }, { "start_pos": 459, "end_pos": 461 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MRA9-1", "uniprot_ac": "F1MRA9", "uniprot_id": "F1MRA9_BOVIN", "mass": { "chemical_mass": 44119.0, "monoisotopic_mass": 44119.0 }, "refseq": { "ac": "XP_005223907", "name": "p21-activated protein kinase-interacting protein 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223907" }, "gene_names": [ { "name": "PAK1IP1", "type": "recommended", "evidence": [ { "id": "F1MRA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRA9" } ] }, { "name": "PAK1IP1", "type": "synonym", "evidence": [ { "id": "XP_005223907", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223907" } ] } ], "protein_names": [ { "name": "p21-activated protein kinase-interacting protein 1", "type": "recommended", "evidence": [ { "id": "F1MRA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRA9/entry#names_and_taxonomy" } ] }, { "name": "PAK1-interacting protein 1", "type": "synonym", "evidence": [ { "id": "F1MRA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRA9/entry#names_and_taxonomy" } ] }, { "name": "p21-activated protein kinase-interacting protein 1 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005223907", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223907" } ] } ], "function": [ { "annotation": "Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.", "evidence": [ { "database": "UniProtKB", "id": "F1MRA9", "url": "https://www.uniprot.org/uniprotkb/F1MRA9#function" }, { "database": "UniProtKB", "id": "ARBA00045213", "url": "https://www.uniprot.org/uniprotkb/ARBA00045213#function" }, { "database": "UniProtKB", "id": "A0AAA9SXW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXW6#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MRA9", "url": "https://www.uniprot.org/uniprotkb/F1MRA9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PAK1IP1", "url": "https://www.uniprot.org/uniprotkb/F1MRA9", "locus": { "chromosome": "23", "start_pos": 45417558, "end_pos": 45428505, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000018674", "url": "https://www.ensembl.org/id/ENSBTAG00000018674" } ] } } ], "crossref": [ { "id": "F1MRA9", "url": "https://alphafold.ebi.ac.uk/entry/F1MRA9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000018674", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000018674", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "505125", "url": "https://www.ncbi.nlm.nih.gov/gene/505125", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IIIWRTK", "url": "https://omabrowser.org/oma/group/IIIWRTK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MRA9", "url": "https://www.orthodb.org/?gene=F1MRA9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44675", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44675", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44675:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44675:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005223907", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223907", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SXW6", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXW6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SXW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXW6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRA9", "url": "https://www.uniprot.org/uniprotkb/F1MRA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRA9-1", "url": "https://www.uniprot.org/uniprotkb/F1MRA9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVVAGCYEQVLFGFAVHPEPVGDGHREQRWAPVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKVDHGALMHHNGTITCLKFHGNRHLISGAEDGLICVWDARRWECLKSIRAHKGHVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQSAHIVEWSPKGEKYVVVILNRIDVYQLDTASVSGTITNERRVSSVTFLSESVLTVAGDEEVVRFFDCDSLTCLSEFKAHENRVKDMFSFETPEHHVLVTASSDGFIKMWKLKQDKKVSPSLLCEINTNARLTCLGVWLDRRTDTKESPPAAAEPAPVSKEQSRRNKEESGHAVQEEEKQPKPDAEKCSLTGDSNKPTRGNSLVSAKKRKTVEMLEKKRKKKKIRMMQ", "length": 393, "header": "tr|F1MRA9-1|F1MRA9_BOVIN Isoform 1 of p21-activated protein kinase-interacting protein 1 OS=Bos taurus OX=9913 GN=PAK1IP1 PE=4 SV=3 CANONICAL=F1MRA9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SXW6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXW6/entry", "sequence": { "sequence": "MMRKASNVEKRLQQSMQRWAPVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKVDHGALMHHNGTITCLKFHGNRHLISGAEDGLICVWDARRWECLKSIRAHKGHVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQSAHIVEWSPKGEKYVVVILNRIDVYQLDTASVSGTITNERRVSSVTFLSESVLTVAGDEEVVRFFDCDSLTCLSEFKAHENRVKDMFSFETPEHHVLVTASSDGFIKMWKLKQDKKVSPSLLCEINTNARLTCLGVWLDRRTDTKESPPAAAEPAPVSKEQSRRNKEESGHAVQEEEKQPKPDAEKCSLTGDSNKPTRGNSLVSAKKRKTVEMLEKKRKKKKIRMMQ", "length": 381, "header": "tr|A0AAA9SXW6-1|F1MRA9_BOVIN Computationally mapped isoform of p21-activated protein kinase-interacting protein 1 OS=Bos taurus OX=9913 GN=PAK1IP1 PE=4 SV=1 CANONICAL=F1MRA9-1" }, "locus": { "chromosome": "23", "start_pos": 45427664, "end_pos": 45417620, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098892.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098892.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000088154.1", "url": "https://www.ensembl.org/id/ENSBTAP00000088154.1" } ] } }, { "isoform_ac": "F1MRA9-1", "url": "https://www.uniprot.org/uniprotkb/F1MRA9/entry", "sequence": { "sequence": "MEVVAGCYEQVLFGFAVHPEPVGDGHREQRWAPVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKVDHGALMHHNGTITCLKFHGNRHLISGAEDGLICVWDARRWECLKSIRAHKGHVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQSAHIVEWSPKGEKYVVVILNRIDVYQLDTASVSGTITNERRVSSVTFLSESVLTVAGDEEVVRFFDCDSLTCLSEFKAHENRVKDMFSFETPEHHVLVTASSDGFIKMWKLKQDKKVSPSLLCEINTNARLTCLGVWLDRRTDTKESPPAAAEPAPVSKEQSRRNKEESGHAVQEEEKQPKPDAEKCSLTGDSNKPTRGNSLVSAKKRKTVEMLEKKRKKKKIRMMQ", "length": 393, "header": "tr|F1MRA9-1|F1MRA9_BOVIN Isoform 1 of p21-activated protein kinase-interacting protein 1 OS=Bos taurus OX=9913 GN=PAK1IP1 PE=4 SV=3 CANONICAL=F1MRA9-1" }, "locus": { "chromosome": "23", "start_pos": 45428306, "end_pos": 45417620, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000024854.6", "url": "https://www.ensembl.org/id/ENSBTAT00000024854.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000024854.5", "url": "https://www.ensembl.org/id/ENSBTAP00000024854.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Y560-1", "protein_name": "p21-activated protein kinase-interacting protein 1-like", "gene_name": "PAK1IP1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKRCGSFSSLNHRMARVGRDLKDNEAPTPPPQPWTVTPDFTHHAHTASLSAVAVNSKYVVTGSRDESIQIYDMRKKVEHGALLQHNGTITCLEFYGTAHLLSGAEDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNLKQNAHIIKWSPDGEKYVTVITNKVDIYKLDTASITGTITIEKRISSIRFITDSVLAIAGDDEIIRFYSCDSQKCLCEFKAHENRIKDIYSFEREGQHVIVTASSDGYIKVWNLDLNKINNVPSLLCEVSTKARLTCLAVWLDQASEMKENCGKAATSTEANESEKPSAVKKKKVCGMNKSGKLTKQRRRIVPAKRKLEAPLQKKKKKQNSSE", "length": 379 }, "evidence": [ { "id": "F1MRA9", "url": "https://omabrowser.org/oma/group/F1MRA9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HST8-1", "protein_name": "p21-activated protein kinase-interacting protein 1", "gene_name": "Pak1ip1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MELVAGSYEQVLFGFAVHRKPAKSGDRETWTPVADFTHHAHTASLSAVASNSRFVVTGSKDETIHIYDMKKKIDHGSLVHHSGTITCLKFYGSRHLISGAEDGLICVWDAKKWECLKSIKAHKGHVTFLSIHPSGKLALSVGTDKTLRTWNLIEGRSAFIKNIKQNAHIVEWSPSGEKYIVVVLNKVDVYQLDTASVSGTITNGKRISSVTFLSDSVLAVAGDEEVVRFFDCGSLVCLCEFKAHENRVKDMFSFEIPDHRVLVTASNDGFIKMWMLKQNKRDPPSLLCEVNTGARLTCLGVWLDKETDEKASLPPATEPSPVNKEQPKRIKKECCDVVQKEETPGPGSKTSSLTDDSKEPTRGNSPVSAKKRKVTNMLKKRKKKM", "length": 385 }, "evidence": [ { "id": "F1MRA9", "url": "https://omabrowser.org/oma/group/F1MRA9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q9DCE5-1", "protein_name": "p21-activated protein kinase-interacting protein 1", "gene_name": "Pak1ip1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELVAGSYEQVLFGFTVQRGPAKSGHQETWTPVADFTHHSHTASLSVLASNSRYVVSGSKDETIHIYDMKRKVEHGALVHHAGTVTCLKFHGNQHLISGAEDGHICIWDVKRWKCLKTFKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLIEGRSAFIKNIKENAHIVEWSPSGGKYIVVVQNKVDVYRLGTASVSGTITNGKRISSVTFLSDSVLAVAGDEEVVRIFDCDSLECLCEFRAHENRVKDMVSFEVPDHHVLVTASNDGFIKMWTLPQDKKVPPSLLCEAKTGARLTCLTVWLDRAANGMASLPPAAEPCPDQPKTIEKESGDTVQEETSEPNSEKSDVSGDSKQPTKGNSPVTAKKRKMATMSEKKRKKKM", "length": 382 }, "evidence": [ { "id": "F1MRA9", "url": "https://omabrowser.org/oma/group/F1MRA9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NWT1-1", "protein_name": "p21-activated protein kinase-interacting protein 1", "gene_name": "PAK1IP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLTCLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSKKATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ", "length": 392 }, "evidence": [ { "id": "F1MRA9", "url": "https://omabrowser.org/oma/group/F1MRA9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VXW4-1", "protein_name": "CG9123", "gene_name": "Dmel\\CG9123", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPPEMEIIEATNEELLLGFKLIKSPTDGFTDSVKFELKQTFADSSYARSITSLAVQWPWVASGGTDGRIFVYDMRTRKQSQIILSHAGRVNTLKFTPDLSLLLSGSDDGHMIATRVGSWTKEYDWQKAHAGQAVTHVSCHPSSKLALSLGGDQVLNTWNLVNGCVAHKTNLKNKATLDFQTGCLSWSKQGDHFTLSGPLVLEIWGIENAHVMRRIEMPSKPICITWLDGNECLTGLDNGNIAWISLKDEDDTPPTFILAHEVRVKAIAYLNEFLATVSIAGQIKVWKIDMETRKLEEIARSFMDCRPTDLGLLDLRQFGNVRPVEQRTKVEEKPKAKVESDQSAKPAAPRGFVTIEYEQDKKLDAEKKKEKKKNKKDEESSEESNSSEDKENDDFSDSDSDVSSDHGHRKRKPMKREQQPTPASKGKAKQQKKK", "length": 434 }, "evidence": [ { "id": "F1MRA9", "url": "https://omabrowser.org/oma/group/F1MRA9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "F1MRA9", "url": "https://www.uniprot.org/uniprotkb/F1MRA9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "ribosome biogenesis", "id": "GO:0042254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042254", "evidence": [ { "database": "UniProtKB", "id": "F1MRA9", "url": "https://www.uniprot.org/uniprotkb/F1MRA9" } ], "pmid": "" }, { "name": "negative regulation of signal transduction", "id": "GO:0009968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009968", "evidence": [ { "database": "UniProtKB", "id": "F1MRA9", "url": "https://www.uniprot.org/uniprotkb/F1MRA9" } ], "pmid": "" }, { "name": "regulation of signal transduction by p53 class mediator", "id": "GO:1901796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901796", "evidence": [ { "database": "UniProtKB", "id": "F1MRA9", "url": "https://www.uniprot.org/uniprotkb/F1MRA9" } ], "pmid": "" }, { "name": "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "id": "GO:0000463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000463", "evidence": [ { "database": "UniProtKB", "id": "F1MRA9", "url": "https://www.uniprot.org/uniprotkb/F1MRA9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "protein kinase inhibitor activity", "id": "GO:0004860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004860", "evidence": [ { "database": "UniProtKB", "id": "F1MRA9", "url": "https://www.uniprot.org/uniprotkb/F1MRA9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MRA9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 393, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MRA9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MRA9" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 83, "end_pos": 85 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMU3-1", "uniprot_ac": "F1MMU3", "uniprot_id": "F1MMU3_BOVIN", "mass": { "chemical_mass": 87136.0, "monoisotopic_mass": 87136.0 }, "refseq": {}, "gene_names": [ { "name": "BRD3", "type": "recommended", "evidence": [ { "id": "F1MMU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMU3" } ] } ], "protein_names": [ { "name": "Bromodomain-containing protein 2", "type": "recommended", "evidence": [ { "id": "F1MMU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMU3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMU3", "url": "https://www.uniprot.org/uniprotkb/F1MMU3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BRD3", "url": "https://www.uniprot.org/uniprotkb/F1MMU3", "locus": { "chromosome": "11", "start_pos": 104800267, "end_pos": 104838104, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010582", "url": "https://www.ensembl.org/id/ENSBTAG00000010582" } ] } } ], "crossref": [ { "id": "F1MMU3", "url": "https://alphafold.ebi.ac.uk/entry/F1MMU3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010582", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010582", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05497", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05497", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05498", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05498", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "525051", "url": "https://www.ncbi.nlm.nih.gov/gene/525051", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027353", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027353", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038336", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038336", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043509", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043509", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050935", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050935", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MMU3", "url": "https://www.orthodb.org/?gene=F1MMU3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22880", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22880", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22880:SF246", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22880:SF246", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00439", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00439", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17035", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17035", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9SYS3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYS3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SYS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYS3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMU3", "url": "https://www.uniprot.org/uniprotkb/F1MMU3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMU3-1", "url": "https://www.uniprot.org/uniprotkb/F1MMU3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTATPVAPTGIPAAPGPVNPPPPEVSNPAKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPASGTQSAGSQQVAAVSSVCPATPFQSVPPTVSQTPVIAATPVPTITANATPVPVPPAAAPPPPATPIIPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGRLSEHLRHCDSILKEMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKKKMDSREYPDAQGFAADIRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPAEAPALPAPAAPVVSKGVESSRSSDESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKRKKEKKEKKKKDKDKERHKAKAEEEKRAKAATPAKQAPQKKAPAKKANSTSAAGRQPKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSTSGKKQAAKSKEELAQEKKKELERRLQDVSGQLSNSKKPAKRVGLHRVRGALAAQQQQLLRVRQQQHERIQLRQQRLRVSPGRARLGTQPVAAAAAGTPRPSPRRLIYSFRSMACRLSFHFSVMVSSSSGFNRSTRIFLCVSIRL", "length": 787, "header": "tr|F1MMU3-1|F1MMU3_BOVIN Isoform 1 of Bromodomain-containing protein 2 OS=Bos taurus OX=9913 GN=BRD3 PE=3 SV=2 CANONICAL=F1MMU3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SYS3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYS3/entry", "sequence": { "sequence": "MSTATPVAPTGIPAAPGPVNPPPPEVSNPAKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPASGTQSAGSQQVAAVSSVCPATPFQSVPPTVSQTPVIAATPVPTITANATPVPVPPAAAPPPPATPIIPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGRLSEHLRHCDSILKEMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKKKMDSREYPDAQGFAADIRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPAEAPALPAPAAPVVSKGVESSRSSDESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKRKKEKKEKKKKDKDKERHKAKAEEEKRAKAATPAKQAPQKKAPAKKANSTSAAGRQPKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSTSGKKQAAKSKEELAQEKKKELERRLQDVSGQLSNSKKPAKRGSRPEAARKPRLYQQEPGLWLDV", "length": 707, "header": "tr|A0AAA9SYS3-1|F1MMU3_BOVIN Computationally mapped isoform of Bromodomain-containing protein 2 OS=Bos taurus OX=9913 GN=BRD3 PE=3 SV=1 CANONICAL=F1MMU3-1" }, "locus": { "chromosome": "11", "start_pos": 104824216, "end_pos": 104800920, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000121916.2", "url": "https://www.ensembl.org/id/ENSBTAT00000121916.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091602.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091602.1" } ] } }, { "isoform_ac": "F1MMU3-1", "url": "https://www.uniprot.org/uniprotkb/F1MMU3/entry", "sequence": { "sequence": "MSTATPVAPTGIPAAPGPVNPPPPEVSNPAKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPASGTQSAGSQQVAAVSSVCPATPFQSVPPTVSQTPVIAATPVPTITANATPVPVPPAAAPPPPATPIIPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGRLSEHLRHCDSILKEMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKKKMDSREYPDAQGFAADIRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPAEAPALPAPAAPVVSKGVESSRSSDESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKRKKEKKEKKKKDKDKERHKAKAEEEKRAKAATPAKQAPQKKAPAKKANSTSAAGRQPKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSTSGKKQAAKSKEELAQEKKKELERRLQDVSGQLSNSKKPAKRVGLHRVRGALAAQQQQLLRVRQQQHERIQLRQQRLRVSPGRARLGTQPVAAAAAGTPRPSPRRLIYSFRSMACRLSFHFSVMVSSSSGFNRSTRIFLCVSIRL", "length": 787, "header": "tr|F1MMU3-1|F1MMU3_BOVIN Isoform 1 of Bromodomain-containing protein 2 OS=Bos taurus OX=9913 GN=BRD3 PE=3 SV=2 CANONICAL=F1MMU3-1" }, "locus": { "chromosome": "11", "start_pos": 104824216, "end_pos": 104804958, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013992.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013992.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013992.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013992.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 189, "start_aa": "Thr", "end_pos": 189, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr189", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 233, "start_aa": "Thr", "end_pos": 233, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr233", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "F1MMU3", "url": "https://www.uniprot.org/uniprotkb/F1MMU3" } ], "pmid": "" }, { "name": "chromatin remodeling", "id": "GO:0006338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006338", "evidence": [ { "database": "UniProtKB", "id": "F1MMU3", "url": "https://www.uniprot.org/uniprotkb/F1MMU3" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1MMU3", "url": "https://www.uniprot.org/uniprotkb/F1MMU3" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "F1MMU3", "url": "https://www.uniprot.org/uniprotkb/F1MMU3" } ], "pmid": "" }, { "name": "protein localization to chromatin", "id": "GO:0071168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071168", "evidence": [ { "database": "UniProtKB", "id": "F1MMU3", "url": "https://www.uniprot.org/uniprotkb/F1MMU3" } ], "pmid": "" }, { "name": "endodermal cell differentiation", "id": "GO:0035987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035987", "evidence": [ { "database": "UniProtKB", "id": "F1MMU3", "url": "https://www.uniprot.org/uniprotkb/F1MMU3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MMU3", "url": "https://www.uniprot.org/uniprotkb/F1MMU3" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MMU3", "url": "https://www.uniprot.org/uniprotkb/F1MMU3" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1MMU3", "url": "https://www.uniprot.org/uniprotkb/F1MMU3" } ], "pmid": "" } ] }, { "name": "Molecular Function", 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"database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTLAGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEESEKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMPTLPTYQLSETSYQPTAIPQAVSDPSSTVHRPQPLPPSTVHQSTLPSNPDSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPAIGNGLSPQVMGLLTNHGGVPHQPQTDYALSPLTGGLEPTTTVSASCSQRLDHMKSLDSLPTSQSYCPPTYSTTGYSMDPVTGYQYGQYGQSAFHYLKPDIA", "length": 484, "header": "tr|F1MTX0-1|F1MTX0_BOVIN Isoform 1 of Paired box 3 OS=Bos taurus OX=9913 GN=PAX3 PE=3 SV=2 CANONICAL=F1MTX0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZE6-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZE6/entry", "sequence": { "sequence": 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"https://www.ebi.ac.uk/interpro/entry/IPR022682", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022684", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022684", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036727", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036727", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:536988", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536988", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DICENPR", "url": "https://omabrowser.org/oma/group/DICENPR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MQD1", "url": "https://www.orthodb.org/?gene=F1MQD1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10183", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10183", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10183:SF402", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10183:SF402", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15357", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15357", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15357:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15357:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00648", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00648", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01067", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01067", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06554", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06554", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1474228", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1474228", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001179823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179823", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9SZV2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZV2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9SZV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZV2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3U5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3U5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLV3", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0ABI0NLV3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLV3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQD1", "url": "https://www.uniprot.org/uniprotkb/F1MQD1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQD1-1", "url": "https://www.uniprot.org/uniprotkb/F1MQD1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFSCVKPYENQNYSALKRACLRRKVLFEDPNFPATDDSLYYKGSPGPTVRWKRPKDICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSSSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDEAKRNQLFERVLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAITDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKLGVTVQDDGEFWMTFEDLCRYFTDIIKCRLINTSYLSIHKTWEEARLRGAWTRHEDPLQNRSGGCINHKDSFFQNPQYIFDVKKPEDEVLISIQQRPKQSTRRDGKGENLAIGFDIYKVEENRQYRMHSLQHRAASSIYINSRSVFLRTEQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPRTCWSSLCGYPQQVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYDVKGVFYRKKPSQPITVQIWNHRVLKDEFLGQVHLKANADDLQALHTLHLRDRNSRQPSDLPGTVAVRVLSSASLTAV", "length": 640, "header": "tr|F1MQD1-1|F1MQD1_BOVIN Isoform 1 of Calpain-5 OS=Bos taurus OX=9913 GN=CAPN5 PE=3 SV=2 CANONICAL=F1MQD1-1" }, "isoforms": [ { "isoform_ac": "A0AAA9SZV2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SZV2/entry", "sequence": { "sequence": "MAEDEPKPSQLSMPLVLDRDLTKQMRLRMESLTQRGQKRQDGEKLLRPSESVYRIDFIQQHRLQFERWDVVLDQPGKVTITGTSQNWTPDLTNLMTRQLLDPAAIFWRKEDSEAMDWNEADALEFGERLSDLAKIRKVMYFLITFSEGLEPANLKASVVFNQL", "length": 163, "header": "tr|A0AAA9SZV2-1|F1MQD1_BOVIN Computationally mapped isoform of Calpain-5 OS=Bos taurus OX=9913 GN=CAPN5 PE=3 SV=1 CANONICAL=F1MQD1-1" }, "locus": { "chromosome": "15", "start_pos": 56505108, "end_pos": 56504620, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131532.2", "url": "https://www.ensembl.org/id/ENSBTAT00000131532.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101046.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101046.1" } ] } }, { "isoform_ac": "A0AAA9T3U5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3U5/entry", "sequence": { "sequence": "MFSCVKPYENQNYSALKRACLRRKVLFEDPNFPATDDSLYYKGSPGPTVRWKRPKDICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKTVEAAAAASSKWAMAEDEPKPSQLSMPLVLDRDLTKQMRLRMESLTQRGQKRQDGEKLLRPSESVYRIDFIQQHRLQFERWDVVLDQPGKVTITGTSQNWTPDLTNLMTRQLLDPAAIFWRKEDSEAMDWNEADALEFGERLSDLAKIRKVMYFLITFSEGLEPANLKAS", "length": 269, "header": "tr|A0AAA9T3U5-1|F1MQD1_BOVIN Computationally mapped isoform of Calpain-5 OS=Bos taurus OX=9913 GN=CAPN5 PE=3 SV=1 CANONICAL=F1MQD1-1" }, "locus": { "chromosome": "15", "start_pos": 56505090, "end_pos": 56489427, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114838.2", "url": "https://www.ensembl.org/id/ENSBTAT00000114838.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093472.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093472.1" } ] } }, { "isoform_ac": "A0ABI0NLV3-1", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NLV3/entry", "sequence": { "sequence": "MFSCVKPYENQNYSALKRACLRRKVLFEDPNFPATDDSLYYKGSPGPTVRWKRPKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSSSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDEAKRNQLFERVLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAITDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKLGVTVQDDGEFWMTFEDLCRYFTDIIKCRLINTSYLSIHKTWEEARLRGAWTRHEDPLQNRSGGCINHKDSFFQNPQYIFDVKKPEDEVLISIQQRPKQSTRRDGKGENLAIGFDIYKVEENRQYRMHSLQHRAASSIYINSRSVFLRTEQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPRTCWSSLCGYPQQVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYDVKGVFYRKKPSQPITVQIWNHRVLKDEFLGQVHLKANADDLQALHTLHLRDRNSRQPSDLPGTVAVRVLSSASLTAV", "length": 596, "header": "tr|A0ABI0NLV3-1|A0ABI0NLV3_BOVIN Computationally mapped isoform of Calpain-5 OS=Bos taurus OX=9913 GN=OMP PE=3 SV=1 CANONICAL=F1MQD1-1" }, "locus": { "chromosome": "15", "start_pos": 56527855, "end_pos": 56489427, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000151183.1", "url": "https://www.ensembl.org/id/ENSBTAT00000151183.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000106190.1", "url": "https://www.ensembl.org/id/ENSBTAP00000106190.1" } ] } }, { "isoform_ac": "F1MQD1-1", "url": "https://www.uniprot.org/uniprotkb/F1MQD1/entry", "sequence": { "sequence": "MFSCVKPYENQNYSALKRACLRRKVLFEDPNFPATDDSLYYKGSPGPTVRWKRPKDICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSSSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDEAKRNQLFERVLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAITDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKLGVTVQDDGEFWMTFEDLCRYFTDIIKCRLINTSYLSIHKTWEEARLRGAWTRHEDPLQNRSGGCINHKDSFFQNPQYIFDVKKPEDEVLISIQQRPKQSTRRDGKGENLAIGFDIYKVEENRQYRMHSLQHRAASSIYINSRSVFLRTEQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPRTCWSSLCGYPQQVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYDVKGVFYRKKPSQPITVQIWNHRVLKDEFLGQVHLKANADDLQALHTLHLRDRNSRQPSDLPGTVAVRVLSSASLTAV", "length": 640, "header": "tr|F1MQD1-1|F1MQD1_BOVIN Isoform 1 of Calpain-5 OS=Bos taurus OX=9913 GN=CAPN5 PE=3 SV=2 CANONICAL=F1MQD1-1" }, "locus": { "chromosome": "15", "start_pos": 56527855, "end_pos": 56489427, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006638.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006638.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006638.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006638.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 48, "start_aa": "Thr", "end_pos": 48, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr48", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:536988", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:536988", "resource": "KEGG Pathway" }, { "id": "R-BTA-1474228", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1474228", "resource": "Reactome", "description": "Degradation of the extracellular matrix" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M3ATX3-1", "protein_name": "Calpain-5 isoform X1", "gene_name": "capn5b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MFSSAKAFEGQHYSTLKRQCLQSGALFEDPLFPAVDDSLFYQGNRIGRVHWKRPEELCDDPHLFVDGISAHDLHQGQLGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKADSYAGIFHFRFWRFGEWVDVVIDDRLPTVDNQLVYCHSNDSNEFWSALVEKAYAKVYGCYEALDGGNTADALVDFTGGVSEPMDLLEGQFAQDETARNQLFERVLKVHNRDGLISCSIRATTVEDMEARLDCGLVKGHAYAVTDVRKVRLGHGLLAYFKSEKLHMIRMRNPWGEKEWSGPWSDSSEEWKKVSKSEREKLGVTVQDDGEFWMNFEDFCHYFTDLILCRLINTSYLSIHKTWEEEVMRGLWLHRDEPLRNRAGGCINHKTTFLQNPQYVFDVRKVEDEVLICLQQKERRATPKEGKGENLAIGFDIHRVELNRKYRMHSAQQKVAGSIYINSRCVFLRKELKEGRYVIIPTTFDPGQQGEFLLRVFTDVPSDCKELTLDEPPQTCWTGMCGYPQLVTQVHVLSAEGLQGQDANGELHCLISHKTHSDFCTRASDPYVIITCEGEKVRSPVHKDTRCPNFDIKGIFYRKKPKEGIHIEIYNKNVIVDTFLGQVTLFSDPNDRQEQHTVYLKDKGSRQDNNLPGTLTVRVITCTTLTNI", "length": 659 }, "evidence": [ { "id": "F1MQD1", "url": "https://omabrowser.org/oma/group/F1MQD1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3I7G1-1", "protein_name": "Calpain-5", "gene_name": "Capn5", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MISTFSCVKSYEDQSYSGLKRACLRRKVLFEDPNFPATDDSLYYKSTPGPTVSWKRPKDICDDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASREVLWQKVIPDWKEQEWNPEKPDAYAGIFHFQFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGNFANDEAKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSQEWKKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRLINTSYLSFHKTWEEVQLRGAWTRHGNPKQDRSGGCVNYKDTFFQNPQYIFEVKKPEDEILICIQQRPKRSTRVEGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTEQAEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWTSLCGYPQQVTQIHVLQAAGLKRFPAGANSYVIIKCEGEKVRSAVQKGTSTPEYNVKGIFYRKKLTQPITVQIWNRRVLKDEFLGQVCLKANPEDQQALHILHLQDRSQQPRDLPGTITVSILSSASLTAV", "length": 642 }, "evidence": [ { "id": "F1MQD1", "url": "https://omabrowser.org/oma/group/F1MQD1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "O08688-1", "protein_name": "Calpain-5", "gene_name": "Capn5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSCAKAYEDQNYSALKRACLRKKVLFEDPLFPATDDSLYYKGTPGPTVRWKRPKDICDDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWNPEKPDSYAGIFHFNFWRFGEWVDVIVDDRLPTVNNQLIYCHSNSKNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDLATDEAKRNQLFERVLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWTGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDMCRYFTDIIKCRLINTSYLSIHKTWEEARLHGAWTRHEDPQQNRSGGCINHKDTFFQNPQYVFEVKKPEDEVLISIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTELPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPRTCWSSLCGYPQQVAQVHVLGAAGLKDSPTGANSYVIIKCEGEKVRSAVQRGTSTPEYNVKGIFYRKKLAQPITVQVWNHRVLKDEFLGQVHLKTAPDDLQDLHTLHLQDRSSRQPSDLPGIVAVRVLCSASLTAV", "length": 640 }, "evidence": [ { "id": "F1MQD1", "url": "https://omabrowser.org/oma/group/F1MQD1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O15484-1", "protein_name": "Calpain-5", "gene_name": "CAPN5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLHGAWTLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSSTSLMAV", "length": 640 }, "evidence": [ { "id": "F1MQD1", "url": "https://omabrowser.org/oma/group/F1MQD1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R4C0-1", "protein_name": "Calpain-5", "gene_name": "Capn5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFSCTKAYEYQNYSALKRACLRRKVLFEDPHFPASDDSLYYKGTPGPTVRWKRPFDICDDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWNPEKPDSYAGIFHFNFWRFGEWVDVVVDDRLPTVNNQLIYCHSNSKNEFWCAPVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDLATDEAKRSQLFERVLKVHSRGGLISASIKAMTAADMETRLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGERVWTGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTYEDMCRYFTDIIKCRLINTSYLSIHKTWEEARLRGAWTRHEDPQQNRSGGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHKAASSIYINSRSVFLRTELPEGRYVIIPTTFEPGHTGELLLRVFTDVPSNCRELRLDEPPRTCWSSLCGYPQQVTQVHVLGAAGLKDSSTGANSYVIIKCEGEKVRSAVQRGTSTPEYNVKGIFYRKKLSQPITVQVWNNRVLKDEFLGQVHLKTAPDDLQDLHSLHLQDRSGRQPSDLPGIVAVRVLCSASLTAV", "length": 640 }, "evidence": [ { "id": "F1MQD1", "url": "https://omabrowser.org/oma/group/F1MQD1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MQD1", "url": "https://www.uniprot.org/uniprotkb/F1MQD1" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "F1MQD1", "url": "https://www.uniprot.org/uniprotkb/F1MQD1" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1MQD1", "url": "https://www.uniprot.org/uniprotkb/F1MQD1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "F1MQD1", "url": "https://www.uniprot.org/uniprotkb/F1MQD1" } ], "pmid": "" }, { "name": "sensory perception of smell", "id": "GO:0007608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007608", "evidence": [ { "database": "UniProtKB", "id": "F1MQD1", "url": "https://www.uniprot.org/uniprotkb/F1MQD1" } ], "pmid": "" }, { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "F1MQD1", "url": "https://www.uniprot.org/uniprotkb/F1MQD1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium-dependent cysteine-type endopeptidase activity", "id": "GO:0004198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004198", "evidence": [ { "database": "UniProtKB", "id": "F1MQD1", "url": "https://www.uniprot.org/uniprotkb/F1MQD1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 344, "end_pos": 346, "annotation": "n_glycosylation_sequon" }, { "start_pos": 372, "end_pos": 374, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MQD1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 640, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MQD1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MQD1" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 48 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 12, "end_pos": 14 }, { "start_pos": 344, "end_pos": 346 }, { "start_pos": 372, "end_pos": 374 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MPD8-1", "uniprot_ac": "F1MPD8", "uniprot_id": "F1MPD8_BOVIN", "mass": { "chemical_mass": 142414.0, "monoisotopic_mass": 142414.0 }, "refseq": { "ac": "XP_024847952", "name": "ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847952" }, "gene_names": [ { "name": "ANKS1B", "type": "recommended", "evidence": [ { "id": "F1MPD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPD8" } ] }, { "name": "ANKS1B", "type": "synonym", "evidence": [ { "id": "XP_024847952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847952" } ] } ], "protein_names": [ { "name": "Ankyrin repeat and sterile alpha motif domain-containing protein 1B", "type": "recommended", "evidence": [ { "id": "F1MPD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPD8/entry#names_and_taxonomy" } ] }, { "name": "Amyloid-beta protein intracellular domain-associated protein 1", "type": "synonym", "evidence": [ { "id": "F1MPD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPD8/entry#names_and_taxonomy" } ] }, { "name": "E2A-PBX1-associated protein", "type": "synonym", "evidence": [ { "id": "F1MPD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPD8/entry#names_and_taxonomy" } ] }, { "name": "ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform X1", "type": "synonym", "evidence": [ { "id": "XP_024847952", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847952" } ] } ], "function": [ { "annotation": "Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.", "evidence": [ { "database": "UniProtKB", "id": "F1MPD8", "url": "https://www.uniprot.org/uniprotkb/F1MPD8#function" }, { "database": "UniProtKB", "id": "ARBA00054696", "url": "https://www.uniprot.org/uniprotkb/ARBA00054696#function" } ] }, { "annotation": "Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.", "evidence": [ { "database": "UniProtKB", "id": "F1MPD8", "url": "https://www.uniprot.org/uniprotkb/F1MPD8#function" }, { "database": "UniProtKB", "id": "ARBA00025297", "url": "https://www.uniprot.org/uniprotkb/ARBA00025297#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MPD8", "url": "https://www.uniprot.org/uniprotkb/F1MPD8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ANKS1B", "url": "https://www.uniprot.org/uniprotkb/F1MPD8", "locus": { "chromosome": "5", "start_pos": 62889233, "end_pos": 64047196, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000030994", "url": "https://www.ensembl.org/id/ENSBTAG00000030994" } ] } } ], "crossref": [ { "id": "F1MPD8", "url": "https://alphafold.ebi.ac.uk/entry/F1MPD8", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013979", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013979", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000030994", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000030994", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01274", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01274", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09499", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09499", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09500", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09500", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "615777", "url": "https://www.ncbi.nlm.nih.gov/gene/615777", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041880", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041880", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041882", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041882", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MP37", "url": "https://www.orthodb.org/?gene=F1MP37", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24174", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24174", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24174:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24174:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00023", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00023", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00536", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00536", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00640", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00640", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024847952", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847952", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T060", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T060", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T060-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T060-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM46", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAF6DM46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP37", "url": "https://www.uniprot.org/uniprotkb/F1MP37", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MP37-1", "url": "https://www.uniprot.org/uniprotkb/F1MP37-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPD8", "url": "https://www.uniprot.org/uniprotkb/F1MPD8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MPD8-1", "url": "https://www.uniprot.org/uniprotkb/F1MPD8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSSLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRPTVLEEHIQEDMTQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTINLSPGEVEEDDDDENTCGPSGLWEALTPCNGCRNLGFPILAQESYPKKRNYTMEIVPSASLDTFPSENENFLCDLMDTAVTKKPCSLEIARAPSPRTDNASEVAITAPGTSNHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLDFHRMNHNQEYFEINTSTGCTSFTSNPPVSPLTSSAATTEVKNKETGDTDDLSHQEDIDPPKEYDPGQFAGLLHGSSPACESPENPFHLYGKRDEREEEKDEVSLANSPLPFKQTPIENKSEPVVKKIKPKVVSRTIFHKKSSQLENHTIVGTRTARSGSRNGDQWIVNTGGFVERACTLGRIRSLPKALIDMHLSKTVSKSDSDLIAYPSNEKTSRVNWSESSPADHSSKGNSERTPSFTSEWEEIDKIMNSIDVGINSELREINGENTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQQSSVCEIWTNQNAGFPFSAIHQVHNTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVQIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF", "length": 1285, "header": "tr|F1MPD8-1|F1MPD8_BOVIN Isoform 1 of Ankyrin repeat and sterile alpha motif domain-containing protein 1B OS=Bos taurus OX=9913 GN=ANKS1B PE=4 SV=4 CANONICAL=F1MPD8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T060-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T060/entry", "sequence": { "sequence": "MMWQCHLSAQDYRYYPVDGYSLLKRFPLHPLTGPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINQSSVCEIWTNQNAGFPFSAIHQVHNTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF", "length": 414, "header": "tr|A0AAA9T060-1|F1MPD8_BOVIN Computationally mapped isoform of Ankyrin repeat and sterile alpha motif domain-containing protein 1B OS=Bos taurus OX=9913 GN=ANKS1B PE=4 SV=1 CANONICAL=F1MPD8-1" }, "locus": { "chromosome": "5", "start_pos": 63318266, "end_pos": 62890244, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000116260.1", "url": "https://www.ensembl.org/id/ENSBTAT00000116260.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091072.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091072.1" } ] } }, { "isoform_ac": "A0AAF6DM46-1", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DM46/entry", "sequence": { "sequence": "MMWQCHLSAQDYRYYPVDGYSLLKRFPLHPLTGPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLRSSVCEIWTNQNAGFPFSAIHQVHNTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVQIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF", "length": 450, "header": "tr|A0AAF6DM46-1|F1MPD8_BOVIN Computationally mapped isoform of Ankyrin repeat and sterile alpha motif domain-containing protein 1B OS=Bos taurus OX=9913 GN=ANKS1B PE=4 SV=1 CANONICAL=F1MPD8-1" }, "locus": { "chromosome": "5", "start_pos": 63318266, "end_pos": 62890244, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056361.4", "url": "https://www.ensembl.org/id/ENSBTAT00000056361.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000052722.4", "url": "https://www.ensembl.org/id/ENSBTAP00000052722.4" } ] } }, { "isoform_ac": "F1MP37-1", "url": "https://www.uniprot.org/uniprotkb/F1MP37/entry", "sequence": { "sequence": "MGPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLRTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF", "length": 394, "header": "tr|F1MP37-1|F1MPD8_BOVIN Computationally mapped isoform of Ankyrin repeat and sterile alpha motif domain-containing protein 1B OS=Bos taurus OX=9913 GN=ANKS1B PE=4 SV=4 CANONICAL=F1MPD8-1" }, "locus": { "chromosome": "5", "start_pos": 63318746, "end_pos": 62890244, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043868.5", "url": "https://www.ensembl.org/id/ENSBTAT00000043868.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041406.5", "url": "https://www.ensembl.org/id/ENSBTAP00000041406.5" } ] } }, { "isoform_ac": "F1MPD8-1", "url": "https://www.uniprot.org/uniprotkb/F1MPD8/entry", "sequence": { "sequence": "MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSSLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRPTVLEEHIQEDMTQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTINLSPGEVEEDDDDENTCGPSGLWEALTPCNGCRNLGFPILAQESYPKKRNYTMEIVPSASLDTFPSENENFLCDLMDTAVTKKPCSLEIARAPSPRTDNASEVAITAPGTSNHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLDFHRMNHNQEYFEINTSTGCTSFTSNPPVSPLTSSAATTEVKNKETGDTDDLSHQEDIDPPKEYDPGQFAGLLHGSSPACESPENPFHLYGKRDEREEEKDEVSLANSPLPFKQTPIENKSEPVVKKIKPKVVSRTIFHKKSSQLENHTIVGTRTARSGSRNGDQWIVNTGGFVERACTLGRIRSLPKALIDMHLSKTVSKSDSDLIAYPSNEKTSRVNWSESSPADHSSKGNSERTPSFTSEWEEIDKIMNSIDVGINSELREINGENTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQQSSVCEIWTNQNAGFPFSAIHQVHNTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVQIDPSEQKTLANLPWIVEPGQEAKRGINTKYETTIF", "length": 1285, "header": "tr|F1MPD8-1|F1MPD8_BOVIN Isoform 1 of Ankyrin repeat and sterile alpha motif domain-containing protein 1B OS=Bos taurus OX=9913 GN=ANKS1B PE=4 SV=4 CANONICAL=F1MPD8-1" }, "locus": { "chromosome": "5", "start_pos": 64046997, "end_pos": 62890244, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018579.7", "url": "https://www.ensembl.org/id/ENSBTAT00000018579.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018579.7", "url": "https://www.ensembl.org/id/ENSBTAP00000018579.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 503, "start_aa": "Thr", "end_pos": 503, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr503", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MPD8", "url": "https://www.uniprot.org/uniprotkb/F1MPD8" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MPD8", "url": "https://www.uniprot.org/uniprotkb/F1MPD8" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "F1MPD8", "url": "https://www.uniprot.org/uniprotkb/F1MPD8" } ], "pmid": "" }, { "name": "dendritic spine", "id": "GO:0043197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "database": "UniProtKB", "id": "F1MPD8", "url": "https://www.uniprot.org/uniprotkb/F1MPD8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1157, "end_pos": 1159, "annotation": "n_glycosylation_sequon" }, { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 359, "end_pos": 361, "annotation": "n_glycosylation_sequon" }, { "start_pos": 371, "end_pos": 373, "annotation": "n_glycosylation_sequon" }, { "start_pos": 383, "end_pos": 385, "annotation": "n_glycosylation_sequon" }, { "start_pos": 432, "end_pos": 434, "annotation": "n_glycosylation_sequon" }, { "start_pos": 481, "end_pos": 483, "annotation": "n_glycosylation_sequon" }, { "start_pos": 497, "end_pos": 499, "annotation": "n_glycosylation_sequon" }, { "start_pos": 53, "end_pos": 55, "annotation": "n_glycosylation_sequon" }, { "start_pos": 551, "end_pos": 553, "annotation": "n_glycosylation_sequon" }, { "start_pos": 655, "end_pos": 657, "annotation": "n_glycosylation_sequon" }, { "start_pos": 683, "end_pos": 685, "annotation": "n_glycosylation_sequon" }, { "start_pos": 755, "end_pos": 757, "annotation": "n_glycosylation_sequon" }, { "start_pos": 967, "end_pos": 969, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MPD8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1285, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MPD8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MPD8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MPD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPD8" }, { "id": "PS01179", "database": "PROSITE", "url": "https://prosite.expasy.org/PS01179" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "PID", "eco_id": "ECO_0000259", "start_pos": 1084, "end_pos": 1217, "start_aa": "Ser", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MPD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPD8" }, { "id": "PS50105", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50105" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SAM", "eco_id": "ECO_0000259", "start_pos": 813, "end_pos": 876, "start_aa": "Gln", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 503 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1157, "end_pos": 1159 }, { "start_pos": 128, "end_pos": 130 }, { "start_pos": 359, "end_pos": 361 }, { "start_pos": 371, "end_pos": 373 }, { "start_pos": 383, "end_pos": 385 }, { "start_pos": 432, "end_pos": 434 }, { "start_pos": 481, "end_pos": 483 }, { "start_pos": 497, "end_pos": 499 }, { "start_pos": 53, "end_pos": 55 }, { "start_pos": 551, "end_pos": 553 }, { "start_pos": 655, "end_pos": 657 }, { "start_pos": 683, "end_pos": 685 }, { "start_pos": 755, "end_pos": 757 }, { "start_pos": 967, "end_pos": 969 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MKA8-1", "uniprot_ac": "F1MKA8", "uniprot_id": "F1MKA8_BOVIN", "mass": { "chemical_mass": 108799.0, "monoisotopic_mass": 108799.0 }, "refseq": { "ac": "XP_024837764", "name": "zinc finger protein basonuclin-1 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837764" }, "gene_names": [ { "name": "BNC1", "type": "recommended", "evidence": [ { "id": "F1MKA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ] }, { "name": "BNC1", "type": "synonym", "evidence": [ { "id": "XP_024837764", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837764" } ] } ], "protein_names": [ { "name": "Zinc finger protein basonuclin-1", "type": "recommended", "evidence": [ { "id": "F1MKA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKA8/entry#names_and_taxonomy" } ] }, { "name": "zinc finger protein basonuclin-1 isoform X2", "type": "synonym", "evidence": [ { "id": "XP_024837764", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837764" } ] } ], "function": [ { "annotation": "Transcriptional activator. It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles. Required for the maintenance of spermatogenesis. It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade. May also play a role in the early development of embryos.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9T092", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T092#function" }, { "database": "UniProtKB", "id": "ARBA00054819", "url": "https://www.uniprot.org/uniprotkb/ARBA00054819#function" }, { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "BNC1", "url": "https://www.uniprot.org/uniprotkb/F1MKA8", "locus": { "chromosome": "21", "start_pos": 24784333, "end_pos": 24756143, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015462", "url": "https://www.ensembl.org/id/ENSBTAG00000015462" } ] } } ], "crossref": [ { "id": "F1MKA8", "url": "https://alphafold.ebi.ac.uk/entry/F1MKA8", "database": "AlphaFoldDB", "categories": [] }, { "id": "524182", "url": "https://www.ncbi.nlm.nih.gov/gene/524182", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524182", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524182", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MKA8", "url": "https://www.orthodb.org/?gene=F1MKA8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15021", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15021", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15021:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15021:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12874", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12874", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024837764", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837764", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T092", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T092", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T092-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T092-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKA8-1", "url": "https://www.uniprot.org/uniprotkb/F1MKA8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRCRNMFFSFKASLCGGGAATGLTLTAIGCTLNCSCQSFKPGKINHRQCEQCRHGWVAHALSKLRIPAMYPTSQVEIVQSNVVFDISSLMLYGTQAIPVRLKILLDRLFSVLKQDEVLQILHALDWTLQDYIRGYVLQDASGKVLDHWSIMTSEEEVATLQQFLRFGETKSIVELMAIQEKEEQSVVIPPSTANVDIRAFIESCSHRSASLPTPVDKGNPSSVHPFENLINNMTFMLPFQFFNPLPPALIGSLPDPYVLEQSQDQSQDPKQEVHGAFPDSSFLTSSSTPFQVEKDPCLNCPNAVTKKEDSTHFSDSSSYSIVTKLERTQLSPEAKVKPERNSLGAKKGRVFCTACEKTFYDKGTLKIHYNAVHLKIKHKCTIEGCNMVFSSLRSRNRHSANPNPRLHMPMNRNNRDKDLRSGLTLAASESAKRPGLGVTPPDCRPLPGYAGAVEDSRSQPTFPSLSHNGVLFPNLKTVQPVLPFYRSPATPAELANTPGMLPSLPLLSSSIPEQLASNEMPFDTLPKKKSRKSSMPIKIEKETMETADEKRQPLSSDEDMPLQVVSEDDLETCSPRSDGAPEELHTPAGSSERPRLEEESPCYLGPGVESSGAIRQTPEQAMHNSERETGQKSVLNTVPRDAEEDGREPHLTTRVEPCVPFPDYIKLQQHLLAGGLFGALSTQGMAFPCFEDSKEPEHLGQPASVRSKEENRFQCDICKKTFKNACGVKMHQKNMHSREMHTCTVEGCKASFPSRRSRDRHSSNLNLHQKVLPQEALESGEDPFRAAYLLKDTAQEAYQEAAFTPQASQTSVIFKGMSRMGSLVYPLAQVRSAGLQSYASGLPSEGTVLDLSTTSSVKSESSSHSSWDSDGASEEGAVLTEDCDGTCDGPGLVPGEDYPLCVLMGKADQSLASLPSGLPLTCHLCQKTYSNKGTFRAHYKTVHLRQLHKCKVPGCNTMFSSVRSRNRHSQNPNLHRSLTSSPSHLR", "length": 986, "header": "tr|F1MKA8-1|F1MKA8_BOVIN Isoform 1 of Zinc finger protein basonuclin-1 OS=Bos taurus OX=9913 GN=BNC1 PE=4 SV=4 CANONICAL=F1MKA8-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T092-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T092/entry", "sequence": { "sequence": "MAEAIGCTLNCSCQSFKPGKINHRQCEQCRHGWVAHALSKLRIPAMYPTSQVEIVQSNVVFDISSLMLYGTQAIPVRLKILLDRLFSVLKQDEVLQILHALDWTLQDYIRGYVLQDASGKVLDHWSIMTSEEEVATLQQFLRFGETKSIVELMAIQEKEEQSVVIPPSTANVDIRAFIESCSHRSASLPTPVDKGNPSSVHPFENLINNMTFMLPFQFFNPLPPALIGSLPDPYVLEQSQDQSQDPKQEVHGAFPDSSFLTSSSTPFQVEKDPCLNCPNAVTKKEDSTHFSDSSSYSIVTKLERTQLSPEAKVKPERNSLGAKKGRVFCTACEKTFYDKGTLKIHYNAVHLKIKHKCTIEGCNMVFSSLRSRNRHSANPNPRLHMPMNRNNRDKDLRSGLTLAASESAKRPGLGVTPPDCRPLPGYAGAVEDSRSQPTFPSLSHNGVLFPNLKTVQPVLPFYRSPATPAELANTPGMLPSLPLLSSSIPEQLASNEMPFDTLPKKKSRKSSMPIKIEKETMETADEKRQPLSSDEDMPLQVVSEDDLETCSPRSDGAPEELHTPAGSSERPRLEEESPCYLGPGVESSGAIRQTPEQAMHNSERETGQKSVLNTVPRDAEEDGREPHLTTRVEPCVPFPDYIKLQQHLLAGGLFGALSTQGMAFPCFEDSKEPEHLGQPASVRSKEENRFQCDICKKTFKNACGVKMHQKNMHSREMHTCTVEGCKASFPSRRSRDRHSSNLNLHQKVLPQEALESGEDPFRAAYLLKDTAQEAYQEAAFTPQASQTSVIFKGMSRMGSLVYPLAQVRSAGLQSYASGLPSEGTVLDLSTTSSVKSESSSHSSWDSDGASEEGAVLTEDCDGTCDGPGLVPGEDYPLCVLMGKADQSLASLPSGLPLTCHLCQKTYSNKGTFRAHYKTVHLRQLHKCKVPGCNTMFSSVRSRNRHSQNPNLHRSLTSSPSHLR", "length": 963, "header": "tr|A0AAA9T092-1|F1MKA8_BOVIN Computationally mapped isoform of Zinc finger protein basonuclin-1 OS=Bos taurus OX=9913 GN=BNC1 PE=4 SV=1 CANONICAL=F1MKA8-1" }, "locus": { "chromosome": "21", "start_pos": 24783329, "end_pos": 24756342, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000113960.2", "url": "https://www.ensembl.org/id/ENSBTAT00000113960.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091111.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091111.1" } ] } }, { "isoform_ac": "F1MKA8-1", "url": "https://www.uniprot.org/uniprotkb/F1MKA8/entry", "sequence": { "sequence": "MRCRNMFFSFKASLCGGGAATGLTLTAIGCTLNCSCQSFKPGKINHRQCEQCRHGWVAHALSKLRIPAMYPTSQVEIVQSNVVFDISSLMLYGTQAIPVRLKILLDRLFSVLKQDEVLQILHALDWTLQDYIRGYVLQDASGKVLDHWSIMTSEEEVATLQQFLRFGETKSIVELMAIQEKEEQSVVIPPSTANVDIRAFIESCSHRSASLPTPVDKGNPSSVHPFENLINNMTFMLPFQFFNPLPPALIGSLPDPYVLEQSQDQSQDPKQEVHGAFPDSSFLTSSSTPFQVEKDPCLNCPNAVTKKEDSTHFSDSSSYSIVTKLERTQLSPEAKVKPERNSLGAKKGRVFCTACEKTFYDKGTLKIHYNAVHLKIKHKCTIEGCNMVFSSLRSRNRHSANPNPRLHMPMNRNNRDKDLRSGLTLAASESAKRPGLGVTPPDCRPLPGYAGAVEDSRSQPTFPSLSHNGVLFPNLKTVQPVLPFYRSPATPAELANTPGMLPSLPLLSSSIPEQLASNEMPFDTLPKKKSRKSSMPIKIEKETMETADEKRQPLSSDEDMPLQVVSEDDLETCSPRSDGAPEELHTPAGSSERPRLEEESPCYLGPGVESSGAIRQTPEQAMHNSERETGQKSVLNTVPRDAEEDGREPHLTTRVEPCVPFPDYIKLQQHLLAGGLFGALSTQGMAFPCFEDSKEPEHLGQPASVRSKEENRFQCDICKKTFKNACGVKMHQKNMHSREMHTCTVEGCKASFPSRRSRDRHSSNLNLHQKVLPQEALESGEDPFRAAYLLKDTAQEAYQEAAFTPQASQTSVIFKGMSRMGSLVYPLAQVRSAGLQSYASGLPSEGTVLDLSTTSSVKSESSSHSSWDSDGASEEGAVLTEDCDGTCDGPGLVPGEDYPLCVLMGKADQSLASLPSGLPLTCHLCQKTYSNKGTFRAHYKTVHLRQLHKCKVPGCNTMFSSVRSRNRHSQNPNLHRSLTSSPSHLR", "length": 986, "header": "tr|F1MKA8-1|F1MKA8_BOVIN Isoform 1 of Zinc finger protein basonuclin-1 OS=Bos taurus OX=9913 GN=BNC1 PE=4 SV=4 CANONICAL=F1MKA8-1" }, "locus": { "chromosome": "21", "start_pos": 24783329, "end_pos": 24757551, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000020545.8", "url": "https://www.ensembl.org/id/ENSBTAT00000020545.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000020545.7", "url": "https://www.ensembl.org/id/ENSBTAP00000020545.7" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 490, "start_aa": "Thr", "end_pos": 490, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr490", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:524182", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524182", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "pmid": "" }, { "name": "rDNA binding", "id": "GO:0000182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000182", "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity", "id": "GO:0001216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001216", "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase I", "id": "GO:0006356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006356", "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase I", "id": "GO:0045943", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045943", "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "pmid": "" }, { "name": "positive regulation of oocyte maturation", "id": "GO:1900195", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900195", "evidence": [ { "database": "UniProtKB", "id": "F1MKA8", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 232, "end_pos": 234, "annotation": "n_glycosylation_sequon" }, { "start_pos": 33, "end_pos": 35, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MKA8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 986, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MKA8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MKA8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MKA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKA8" }, { "id": "PS50157", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50157" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2H2-type", "eco_id": "ECO_0000259", "start_pos": 350, "end_pos": 378, "start_aa": "Val", "end_aa": "His", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 490 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 232, "end_pos": 234 }, { "start_pos": 33, "end_pos": 35 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": 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"table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MRP4-1", "uniprot_ac": "F1MRP4", "uniprot_id": "F1MRP4_BOVIN", "mass": { "chemical_mass": 59134.0, "monoisotopic_mass": 59134.0 }, "refseq": { "ac": "NP_001179841", "name": "synaptotagmin-10", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179841" }, "gene_names": [ { "name": "SYT10", "type": "recommended", "evidence": [ { "id": "F1MRP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ] }, { "name": "SYT10", "type": "synonym", "evidence": [ { "id": "NP_001179841", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179841" } ] } ], "protein_names": [ { "name": "Synaptotagmin 10", "type": "synonym", "evidence": [ { "id": "F1MRP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRP4/entry#names_and_taxonomy" } ] }, { "name": "synaptotagmin X", "type": "synonym", "evidence": [ { "id": "NP_001179841", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179841" } ] }, { "name": "synaptotagmin-10", "type": "synonym", "evidence": [ { "id": "NP_001179841", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179841" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SYT10", "url": "https://www.uniprot.org/uniprotkb/F1MRP4", "locus": { "chromosome": "5", "start_pos": 76418339, "end_pos": 76301694, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000000606", "url": "https://www.ensembl.org/id/ENSBTAG00000000606" } ] } } ], "crossref": [ { "id": "F1MRP4", "url": "https://alphafold.ebi.ac.uk/entry/F1MRP4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000000606", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000000606", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08385", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08385", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08403", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08403", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "537613", "url": "https://www.ncbi.nlm.nih.gov/gene/537613", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001565", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001565", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:537613", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537613", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IWKDIHC", "url": "https://omabrowser.org/oma/group/IWKDIHC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MRP4", "url": "https://www.orthodb.org/?gene=F1MRP4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10024", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10024", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10024:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10024:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00168", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179841", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T2S4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2S4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T2S4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2S4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MRP4-1", "url": "https://www.uniprot.org/uniprotkb/F1MRP4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSFHKEDGVSSLCQKALHIVTELCFAGQVEWEKCSSIFPPDGGSQGGSNTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPFWKSKPMTFNVSTLPQSMSSAPTEVFETEEKKEIKENGEPAPKVIEPAIKISHTSPDIPAEVQTAVKEHVIKHARVQRQTTEPTSSSRHNSFRRHLPRQMQVSSVDFGMGTEPILQRGETTTSIGRIKPELYKQKSVDSEDNRKEDVKTCGKLNFTLQYDYENELLVVKIIKALDLPAKDFIGTSDPYVKMYLLPDRKKKFQTRVHRKTLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVIFDNLFEASDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDVTGSSDPYVKVSLMCEGRRLKKKKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAKGLGRDHWNEMLTYHRKPITHWHPLLELPGRATSFDSQGSCPSPKPTSTP", "length": 523, "header": "tr|F1MRP4-1|F1MRP4_BOVIN Isoform 1 of Synaptotagmin 10 OS=Bos taurus OX=9913 GN=SYT10 PE=3 SV=2 CANONICAL=F1MRP4-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T2S4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2S4/entry", "sequence": { "sequence": "MSFHKEDGVSSLCQKALHIVTELCFAGQVEWEKCSSIFPPDGGSQGGSNTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPFWKSKPMTFNVSTLPQSMSSAPTEVFETEEKKEIKENGEPAPKVIEPAIKISHTSPDIPAEVQTAVKEHVIKHARVQRQTTEPTSSSRWIFTICVTRGAPISITGHNSFRRHLPRQMQVSSVDFGMGTEPILQRGETTTSIGRIKPELYKQKSVDSEDNRKEDVKTCGKLNFTLQYDYENELLVVKIIKALDLPAKDFIGTSDPYVKMYLLPDRKKKFQTRVHRKTLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVIFDNLFEASDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDVTGSSDPYVKVSLMCEGRRLKKKKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAKGLGRDHWNEMLTYHRKPITHWHPLLELPGRATSFDSQGSCPSPKPTSTP", "length": 540, "header": "tr|A0AAA9T2S4-1|F1MRP4_BOVIN Computationally mapped isoform of Synaptotagmin 10 OS=Bos taurus OX=9913 GN=SYT10 PE=3 SV=1 CANONICAL=F1MRP4-1" }, "locus": { "chromosome": "5", "start_pos": 76417737, "end_pos": 76301893, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093823.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093823.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092032.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092032.1" } ] } }, { "isoform_ac": "F1MRP4-1", "url": "https://www.uniprot.org/uniprotkb/F1MRP4/entry", "sequence": { "sequence": "MSFHKEDGVSSLCQKALHIVTELCFAGQVEWEKCSSIFPPDGGSQGGSNTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPFWKSKPMTFNVSTLPQSMSSAPTEVFETEEKKEIKENGEPAPKVIEPAIKISHTSPDIPAEVQTAVKEHVIKHARVQRQTTEPTSSSRHNSFRRHLPRQMQVSSVDFGMGTEPILQRGETTTSIGRIKPELYKQKSVDSEDNRKEDVKTCGKLNFTLQYDYENELLVVKIIKALDLPAKDFIGTSDPYVKMYLLPDRKKKFQTRVHRKTLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVIFDNLFEASDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDVTGSSDPYVKVSLMCEGRRLKKKKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAKGLGRDHWNEMLTYHRKPITHWHPLLELPGRATSFDSQGSCPSPKPTSTP", "length": 523, "header": "tr|F1MRP4-1|F1MRP4_BOVIN Isoform 1 of Synaptotagmin 10 OS=Bos taurus OX=9913 GN=SYT10 PE=3 SV=2 CANONICAL=F1MRP4-1" }, "locus": { "chromosome": "5", "start_pos": 76417737, "end_pos": 76301893, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000000798.7", "url": "https://www.ensembl.org/id/ENSBTAT00000000798.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000000798.5", "url": "https://www.ensembl.org/id/ENSBTAP00000000798.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:537613", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:537613", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "E1C2V4-1", "protein_name": "Synaptotagmin 10", "gene_name": "SYT10", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MSFPAEDGVGSLCHKALQIISELCLGGQVEREKCAGIFPLETARQGIGGTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPCWRSKPLTSNASNVPQSTSSAPTEVLETSEKKEVKENGKPTTKVLEAALKISHTSPDIPAEVQNALKEHLIRHARMQRQITEPTSSSRHNSFRRHLPRQMQVSSVDFNMGTDPILQRGETTTSIGRIKPELYKQKSVDSDGQQEDVKTCGKLNFTLRYDYENELLAVTIVKALDLPAKDFTGTSDPYVKIYLLPDRKKKFQTRVHRKTLNPVFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVILDNLFEVSDLSREANVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGASDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGIDAEGLGRDHWNEMLAYPRKPITHWHPLVELPGRATSFDSQGSCSSPKPPLTP", "length": 522 }, "evidence": [ { "id": "F1MRP4", "url": "https://omabrowser.org/oma/group/F1MRP4/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1SGD3-1", "protein_name": "Synaptotagmin 10", "gene_name": "SYT10", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSFHKEDGVSSLCQKALHIVTELCFAGQVEWEKCSSIFPPDRGSQGESSTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPCWKSKPVTSNVTTLPQSISSAPTEVFETEEKKEVKENGKPALKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQRQTTEPTSSSRHNSFRRHLPRQMQVSSVDFGMGTEPVLQRRETTTSIGRIKPELYKQKSVDSEGNRKEDVKTCGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPDRKKKYQTRVHRKTLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVILDNLFEASDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCPSPKPPSTP", "length": 523 }, "evidence": [ { "id": "F1MRP4", "url": "https://omabrowser.org/oma/group/F1MRP4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "O08625-1", "protein_name": "Synaptotagmin-10", "gene_name": "Syt10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSFRKEDGVSSLCQKALHIITELCFAGQVEWDKCSGIFPADRSGQGGGGTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPCWKSKLVAPNVSTLPQSISSAPTEVFETEEKKEVEENEKPAPKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQRQTTDPTSSSRHNSFRRHLPRQMNVSSVDFSMGTEPVLQRGETRTSIGRIKPELYKQKSVDSEGNRKDDVKTCGKLNFALQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKIYLLPDRKKKFQTRVHRKTLNPLFDELFQFPVVYDQLSNRKLHFSIYDFDRFSRHDMIGEVILDNLFEVSDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLCIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCSSPRPPSTP", "length": 523 }, "evidence": [ { "id": "F1MRP4", "url": "https://omabrowser.org/oma/group/F1MRP4/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6XYQ8-1", "protein_name": "Synaptotagmin-10", "gene_name": "SYT10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSFHKEDGVNSLCQKALHIVTELCFAGQVEWEKCSGIFPRDRGSQGGSSTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPCWKSKPVTSNITTLPQSISSAPTEVFETEEKKEIKENEKPAVKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQRQITEPTSSTRHSSFRRHLPRQMQVSSVDFSMGTEPVLQRGETTTSIGRIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPDRKKKFQTRVHRKTLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVILDNLFEVSDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCPSPKPPSTP", "length": 523 }, "evidence": [ { "id": "F1MRP4", "url": "https://omabrowser.org/oma/group/F1MRP4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9R0N4-1", "protein_name": "Synaptotagmin-10", "gene_name": "Syt10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSFRKEDGVSSLCQKALHIITELCFAGQVEWDKCSGIFPADRSGQGGGGTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPCWKSKLVAPNLSVLPQSISSAPTEVFETEEKKEVEENEKPAPKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQRQTTEPTSSSRHNSFRRHLPRQMNVSSVDFSVGTEPILQRGETRTSIGRIKPELYKQKSVDSEGNRKDDVKTCGKLNFALQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKIYLLPDRKKKFQTRVHRKTLNPLFDELFQFPVVYDQLSNRKLHFSIYDFDRFSRHDMIGEVILDNLFEVSDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLCIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCSSPRPPSTP", "length": 523 }, "evidence": [ { "id": "F1MRP4", "url": "https://omabrowser.org/oma/group/F1MRP4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "transport vesicle membrane", "id": "GO:0030658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030658", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "exocytic vesicle", "id": "GO:0070382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070382", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "SNARE binding", "id": "GO:0000149", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000149", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "phosphatidylserine binding", "id": "GO:0001786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "calcium-dependent phospholipid binding", "id": "GO:0005544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005544", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "calcium ion sensor activity", "id": "GO:0061891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061891", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "sensory perception of smell", "id": "GO:0007608", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007608", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "positive regulation of calcium ion-dependent exocytosis", "id": "GO:0045956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045956", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "presynaptic dense core vesicle exocytosis", "id": "GO:0099525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099525", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" }, { "name": "regulation of calcium ion-dependent exocytosis", "id": "GO:0017158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017158", "evidence": [ { "database": "UniProtKB", "id": "F1MRP4", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 236, "end_pos": 238, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MRP4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 523, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MRP4-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MRP4" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MRP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MRP4" }, { "id": "PS50004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "C2", "eco_id": "ECO_0000259", "start_pos": 231, "end_pos": 352, "start_aa": "Thr", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 236, "end_pos": 238 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MM87-1", "uniprot_ac": "F1MM87", "uniprot_id": "F1MM87_BOVIN", "mass": { "chemical_mass": 57017.0, "monoisotopic_mass": 57017.0 }, "refseq": {}, "gene_names": [ { "name": "CEP57", "type": "recommended", "evidence": [ { "id": "F1MM87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ] } ], "protein_names": [ { "name": "Centrosomal protein of 57 kDa", "type": "recommended", "evidence": [ { "id": "F1MM87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM87/entry#names_and_taxonomy" } ] }, { "name": "Translokin", "type": "synonym", "evidence": [ { "id": "F1MM87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM87/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CEP57", "url": "https://www.uniprot.org/uniprotkb/F1MM87", "locus": { "chromosome": "15", "start_pos": 14447587, "end_pos": 14488828, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016547", "url": "https://www.ensembl.org/id/ENSBTAG00000016547" } ] } } ], "crossref": [ { "id": "F1MM87", "url": "https://alphafold.ebi.ac.uk/entry/F1MM87", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016547", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016547", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR024957", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024957", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025913", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025913", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "YMKQMIA", "url": "https://omabrowser.org/oma/group/YMKQMIA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MM87", "url": "https://www.orthodb.org/?gene=F1MM87", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19336", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19336", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19336:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19336:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06657", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06657", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14073", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14073", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T377", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T377", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T377-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T377-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TUE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUE5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM87-1", "url": "https://www.uniprot.org/uniprotkb/F1MM87-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAASVSETSASQFSNILAEPSKSNGSMVRHSSSPYVVYPPDKPFLNSDLRRSPNKPTFAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSKETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQNQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLRQEEQERKRMQAKAAQLQTGLEVNRLIYEDKATSCVPNTKRIKKKKSKPPEKKGSRNYFAVQPHYRLCLGDMPFVAGKSTSPSHAVVANVQHVLHLMKQHSKVLCNDRVVSSIPLAKQVSSRTGKSKKSATPPSSSSVNEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDNLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATRKTLDEEGNSSSRSTTTGTTNKKDFAKPRPGEKSRKNLQLLKDMQSIQNSLQSNSLCWDY", "length": 499, "header": "tr|F1MM87-1|F1MM87_BOVIN Isoform 1 of Centrosomal protein of 57 kDa OS=Bos taurus OX=9913 GN=CEP57 PE=3 SV=3 CANONICAL=F1MM87-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T377-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T377/entry", "sequence": { "sequence": "MAAASVSETSASQFSNILAEPSKSNGSMVRHSSSPYVVYPPDKPFLNSDLRRSPNKPTFAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSKETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQNQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLRQEEQERKRMQAKAAQLQTGLEVNRLIYEDKATSCVPNTKRIKKKKSKPPEKSTSPSHAVVANVQHVLHLMKQHSKVLCNDRVVSSIPLAKQVSSRTGKSKKSATPPSSSSVNEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDNLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATRKTLDEEGNSSSRSTTTGTTNKKDFAKPRPGEKSRKNLQLLKDMQSIQNSLQSNSLCWDY", "length": 473, "header": "tr|A0AAA9T377-1|F1MM87_BOVIN Computationally mapped isoform of Centrosomal protein of 57 kDa OS=Bos taurus OX=9913 GN=CEP57 PE=3 SV=1 CANONICAL=F1MM87-1" }, "locus": { "chromosome": "15", "start_pos": 14488614, "end_pos": 14448591, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000134309.1", "url": "https://www.ensembl.org/id/ENSBTAT00000134309.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000091079.1", "url": "https://www.ensembl.org/id/ENSBTAP00000091079.1" } ] } }, { "isoform_ac": "A0AAA9TUE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TUE5/entry", "sequence": { "sequence": "MATYTLARENRVPGSRGCNGPSWKLRDQNILAEPSKSNGSMVRHSSSPYVVYPPDKPFLNSDLRRSPNKPTFAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSKETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQNQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLRQEEQERKRMQAKAAQLQTGLEVNRLIYEDKATSCVPNTKRIKKKKSKPPEKKGSRNYFAVQPHYRLCLGDMPFVAGKSTSPSHAVVANVQHVLHLMKQHSKVLCNDRVVSSIPLAKQVSSRTGKSKKSATPPSSSSVNEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDNLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATRKTLDEEGNSSSRSTTTGTTNKKDFAKPRPGEKSRKNLQLLKDMQSIQNSLQSNSLCWDY", "length": 512, "header": "tr|A0AAA9TUE5-1|F1MM87_BOVIN Computationally mapped isoform of Centrosomal protein of 57 kDa OS=Bos taurus OX=9913 GN=CEP57 PE=3 SV=1 CANONICAL=F1MM87-1" }, "locus": { "chromosome": "15", "start_pos": 14488319, "end_pos": 14448591, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000129515.1", "url": "https://www.ensembl.org/id/ENSBTAT00000129515.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100730.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100730.1" } ] } }, { "isoform_ac": "F1MM87-1", "url": "https://www.uniprot.org/uniprotkb/F1MM87/entry", "sequence": { "sequence": "MAAASVSETSASQFSNILAEPSKSNGSMVRHSSSPYVVYPPDKPFLNSDLRRSPNKPTFAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSKETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQNQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLRQEEQERKRMQAKAAQLQTGLEVNRLIYEDKATSCVPNTKRIKKKKSKPPEKKGSRNYFAVQPHYRLCLGDMPFVAGKSTSPSHAVVANVQHVLHLMKQHSKVLCNDRVVSSIPLAKQVSSRTGKSKKSATPPSSSSVNEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDNLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATRKTLDEEGNSSSRSTTTGTTNKKDFAKPRPGEKSRKNLQLLKDMQSIQNSLQSNSLCWDY", "length": 499, "header": "tr|F1MM87-1|F1MM87_BOVIN Isoform 1 of Centrosomal protein of 57 kDa OS=Bos taurus OX=9913 GN=CEP57 PE=3 SV=3 CANONICAL=F1MM87-1" }, "locus": { "chromosome": "15", "start_pos": 14488614, "end_pos": 14448591, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049113.4", "url": "https://www.ensembl.org/id/ENSBTAT00000049113.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046049.4", "url": "https://www.ensembl.org/id/ENSBTAP00000046049.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2RAM9-1", "protein_name": "Centrosomal protein of 57 kDa", "gene_name": "CEP57", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAASVSETSASQFSNILAEPSSSGSMVRHSSSPYVVYPPDKPFLNSDLRRSPNKPTFAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSKETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQNQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLREEEQERKRMQAKAAQLQTGLETNRLIFEDKATSCVPNAKRIKKKKSRPSEKKGSRNCCAAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQHVLHLMKQHSKVLCNDRVINNVPLAKQVPSRGGKSKKSATPPSSSSINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDNLECELEALVGRMEAKANQITKVRKYQAQLEKQKIEKQKRELRTTKKTLDEEGNSSSRSSATTGTINKKDFAKPRPGEKSRKNLQLLKDMQTIQNSLQSNNLCWDY", "length": 499 }, "evidence": [ { "id": "F1MM87", "url": "https://omabrowser.org/oma/group/F1MM87/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0XT96-1", "protein_name": "Centrosomal protein 57", "gene_name": "CEP57", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAARGQQRTGDVCRAPRSASATDGLSAASYLDYPTHKPFINSDLLRSPQKPVVPYPESNSRAIFSALRNLQEKIRRLELERLQAEENVKHLSRETADYKKVLSEQMQHRERDRTEVSKRNQELASQLAAAESRYSLLEKQLDYMRKMIQHAEREKTQLLEKQDSLERERLDQSHVQSKLEKLDMLEKEYTRLTTMQSIAEKKMKELEQKLQEEEHARKLVQEKAAELQTGLETNRLLIQAASPLLSPKARKPRKKTKQPEKKCSLTSHLTTQPHYRLCLGDVPFVAGKSTSPSHSVGANVQHVLHLMKHHTKALCNSRVVNDTPLAKSISAGRPGSRSRKPPLPKDYSSSQEELSEVLLTLQDEFGQMSFDHQQLSKLVQEAPTIAVREDLERELEALVGKMEAKADQISKVRRHWLQLERLKREYKSKKASAKHKKDNKFPVSEVKVTTTVTTKGKDAGPIKVKPGEKSRKNLQLLRDMQTIQTSLQKDDISWDY", "length": 497 }, "evidence": [ { "id": "F1MM87", "url": "https://omabrowser.org/oma/group/F1MM87/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q86XR8-1", "protein_name": "Centrosomal protein of 57 kDa", "gene_name": "CEP57", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAASVSAASGSHLSNSFAEPSRSNGSMVRHSSSPYVVYPSDKPFLNSDLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSSLCWDY", "length": 500 }, "evidence": [ { "id": "F1MM87", "url": "https://omabrowser.org/oma/group/F1MM87/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8CEE0-1", "protein_name": "Centrosomal protein of 57 kDa", "gene_name": "Cep57", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAASVSAASDSQFSSVLAEPSRSNGNMVRHSSSPYVLYPPDKPFLNSDLRRSPNKPTFAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELASQLVAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTAMQALAEKKMQELESKLREEEQERKRMQARAAELQSGLEANRLIFEDKTTSCVSTSTRKIKKKKSKPPEKKGSRTYFGAQPHYRLCLGDMPFVAGTSTSPSHAVVANVQHVLHLMKHHSKALCNDRVVNSVPLAKQACSRVSKSKKSVVPPSSSVNEELSDVLQTLQDEFGQMSFDHQQLTKLIQESPTVELKDNLECELEALVGRMEAKANQITKVRKYQAQLEKQNIDKQKKELKANKKTLDEEGNSSGRSSGVPRTASKKDLAKQRPGEKSRKNLQLLKDMQTIQNSLQSSNLCWDY", "length": 500 }, "evidence": [ { "id": "F1MM87", "url": "https://omabrowser.org/oma/group/F1MM87/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ], "pmid": "" }, { "name": "gamma-tubulin binding", "id": "GO:0043015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043015", "evidence": [ { "database": "UniProtKB", "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ], "pmid": "" }, { "name": "fibroblast growth factor binding", "id": "GO:0017134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017134", "evidence": [ { "database": "UniProtKB", "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ], "pmid": "" }, { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ], "pmid": "" }, { "name": "fibroblast growth factor receptor signaling pathway", "id": "GO:0008543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008543", "evidence": [ { "database": "UniProtKB", "id": "F1MM87", "url": "https://www.uniprot.org/uniprotkb/F1MM87" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 25, "end_pos": 27, "annotation": "n_glycosylation_sequon" }, { "start_pos": 448, "end_pos": 450, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MM87-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 499, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MM87-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MM87" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MM87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM87" }, { "id": "PF14073", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14073" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cep57 centrosome localisation", "eco_id": "ECO_0000259", "start_pos": 68, "end_pos": 244, "start_aa": "Ala", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MM87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM87" }, { "id": "PF06657", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06657" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cep57 centrosome microtubule-binding", "eco_id": "ECO_0000259", "start_pos": 348, "end_pos": 419, "start_aa": "Thr", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 25, "end_pos": 27 }, { "start_pos": 448, 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMK7-1", "uniprot_ac": "F1MMK7", "uniprot_id": "F1MMK7_BOVIN", "mass": { "chemical_mass": 33258.0, "monoisotopic_mass": 33258.0 }, "refseq": {}, "gene_names": [ { "name": "RRAD", "type": "recommended", "evidence": [ { "id": "F1MMK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK7" } ] } ], "protein_names": [ { "name": "GTP-binding protein", "type": "recommended", "evidence": [ { "id": "F1MMK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMK7/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMK7", "url": "https://www.uniprot.org/uniprotkb/F1MMK7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RRAD", "url": "https://www.uniprot.org/uniprotkb/F1MMK7", "locus": { "chromosome": "18", "start_pos": 34626239, "end_pos": 34629427, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013929", "url": "https://www.ensembl.org/id/ENSBTAG00000013929" } ] } } ], "crossref": [ { "id": "F1MMK7", "url": "https://alphafold.ebi.ac.uk/entry/F1MMK7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013929", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013929", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04148", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04148", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017358", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017358", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051641", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051641", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MPQTGQT", "url": "https://omabrowser.org/oma/group/MPQTGQT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MMK7", "url": "https://www.orthodb.org/?gene=F1MMK7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45775", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45775", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45775:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45775:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9T3J5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3J5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3J5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3J5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMK7", "url": "https://www.uniprot.org/uniprotkb/F1MMK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMK7-1", "url": "https://www.uniprot.org/uniprotkb/F1MMK7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTLNGGGSGAGGNRGGGRERDRRRGSTPWGPALPLHRRSMPVDERDLQAALSPGALTTAEAGTGAQGPRLDWPEGSSDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSIMVDGEEASLMVYDIWEQDGGRWLPGHCLAMGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSLDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAMRAKSKSCHDLSVL", "length": 308, "header": "tr|F1MMK7-1|F1MMK7_BOVIN Isoform 1 of GTP-binding protein OS=Bos taurus OX=9913 GN=RRAD PE=3 SV=1 CANONICAL=F1MMK7-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3J5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3J5/entry", "sequence": { "sequence": "MDEPGGWVTCQGAKTFRGRSYTPSIFPDPWSGRRVPGPASYSMSTAAYAATRIPVPQTASDAMTLNGGGSGAGGNRGGGRERDRRRGSTPWGPALPLHRRSMPVDERDLQAALSPGALTTAEAGTGAQGPRLDWPEGSSDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSIMVDGEEASLMVYDIWEQDGGRWLPGHCLAMGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSLDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAMRAKSKSCHDLSVL", "length": 370, "header": "tr|A0AAA9T3J5-1|F1MMK7_BOVIN Computationally mapped isoform of GTP-binding protein OS=Bos taurus OX=9913 GN=RRAD PE=3 SV=1 CANONICAL=F1MMK7-1" }, "locus": { "chromosome": "18", "start_pos": 34629278, "end_pos": 34626622, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000101046.1", "url": "https://www.ensembl.org/id/ENSBTAT00000101046.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000092344.1", "url": "https://www.ensembl.org/id/ENSBTAP00000092344.1" } ] } }, { "isoform_ac": "F1MMK7-1", "url": "https://www.uniprot.org/uniprotkb/F1MMK7/entry", "sequence": { "sequence": "MTLNGGGSGAGGNRGGGRERDRRRGSTPWGPALPLHRRSMPVDERDLQAALSPGALTTAEAGTGAQGPRLDWPEGSSDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSIMVDGEEASLMVYDIWEQDGGRWLPGHCLAMGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSLDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAMRAKSKSCHDLSVL", "length": 308, "header": "tr|F1MMK7-1|F1MMK7_BOVIN Isoform 1 of GTP-binding protein OS=Bos taurus OX=9913 GN=RRAD PE=3 SV=1 CANONICAL=F1MMK7-1" }, "locus": { "chromosome": "18", "start_pos": 34629092, "end_pos": 34626622, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018501.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018501.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018501.4", "url": "https://www.ensembl.org/id/ENSBTAP00000018501.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZSB2-1", "protein_name": "GTP-binding protein", "gene_name": "RRAD", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTLNGGGSGAGGSRGGGRERERRRGSTPWGPAPPLHRRSMPVDERDLQAALAPGALATAEAGTAAQGPRLDWPEGSSDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSIMVDGEEASLMVYDIWEQDGGHWLPGHCMAMGDAYVIVYSVTDKDSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSLDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGRIVARNSRKMALRAKSKSCHDLSVL", "length": 308 }, "evidence": [ { "id": "F1MMK7", "url": "https://omabrowser.org/oma/group/F1MMK7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Y4Q3-1", "protein_name": "GTP-binding protein", "gene_name": "RRAD", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTLNRGDKLRYLDKRRGSMPFSAHQHLHRRSMPVDERDLRASLPQDELSGLVRCTSYSPGEAHRESWASDSSDSVISSGSDSDGSLYKVILLGEHGVGKTSLARIFGGVEDGAEAEEAGNTYDRSIMVDGEEASLVVFDIWEQDDSQWLQNHCMKMGDAYIIVYSVTDKVSFEKASELRIQLRRARQTEDIPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVKDLFEGIVRQIRLRKDSKEDNARRMANTKRRESIGKKAKRFLGRIVAKNNKKMAFKAKSKSCHDLSVL", "length": 303 }, "evidence": [ { "id": "F1MMK7", "url": "https://omabrowser.org/oma/group/F1MMK7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "O88667-1", "protein_name": "GTP-binding protein RAD", "gene_name": "Rrad", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTLNGGSGASGSRGAGGRERDRRRGSTPWGPAPPLHRRSMPVDERDLQAALAPGSLATTAAGTRTQGQRLDWPEGSSDSLSSGGSGSEEGVYKVLLLGAPGVGKSALARIFGGIEDGPEAEAAGHTYDRSITVDGEEASLLVYDIWEEDGGCWLPGHCMAMGDAYVIVYSITDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEDNARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL", "length": 308 }, "evidence": [ { "id": "F1MMK7", "url": "https://omabrowser.org/oma/group/F1MMK7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P55042-1", "protein_name": "GTP-binding protein RAD", "gene_name": "RRAD", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTLNGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGALTAAAAGTGTQGPRLDWPEDSEDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSIVVDGEEASLMVYDIWEQDGGRWLPGHCMAMGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL", "length": 308 }, "evidence": [ { "id": "F1MMK7", "url": "https://omabrowser.org/oma/group/F1MMK7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P55043-1", "protein_name": "GTP-binding protein RAD", "gene_name": "Rrad", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTLNGGSGAGGSRSAGRERDRRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGSLAATAAGTRTQGQRLDWPEGSSDSLSSGDSGSEDGVYKVHAAGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSITVDGEEASLMVYDIWEQDGGCWLPGHCMAMGDAYVIVYSITDKGSFEKASELRVQLRARRQTDVPIILVGNKSDLVRSREVSVDEGRACAEVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEDNARRQAGTRRRESLGKKAKLFLGRIVARNSRKMAFLAKSKSCHDLSVL", "length": 306 }, "evidence": [ { "id": "F1MMK7", "url": "https://omabrowser.org/oma/group/F1MMK7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "F1MMK7", "url": "https://www.uniprot.org/uniprotkb/F1MMK7" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1MMK7", "url": "https://www.uniprot.org/uniprotkb/F1MMK7" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "F1MMK7", "url": "https://www.uniprot.org/uniprotkb/F1MMK7" } ], "pmid": "" }, { "name": "calcium channel regulator activity", "id": "GO:0005246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005246", "evidence": [ { "database": "UniProtKB", "id": "F1MMK7", "url": "https://www.uniprot.org/uniprotkb/F1MMK7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MMK7", "url": "https://www.uniprot.org/uniprotkb/F1MMK7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MMK7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 308, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MMK7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MMK7" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 203, "end_pos": 205 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MKY0-1", "uniprot_ac": "F1MKY0", "uniprot_id": "F1MKY0_BOVIN", "mass": { "chemical_mass": 67312.0, "monoisotopic_mass": 67312.0 }, "refseq": { "ac": "XP_024841188", "name": "ADP-ribosylation factor-binding protein GGA2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841188" }, "gene_names": [ { "name": "GGA2", "type": "recommended", "evidence": [ { "id": "F1MKY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" } ] }, { "name": "GGA2", "type": "synonym", "evidence": [ { "id": "XP_024841188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841188" } ] } ], "protein_names": [ { "name": "ADP-ribosylation factor-binding protein GGA2", "type": "synonym", "evidence": [ { "id": "XP_024841188", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841188" } ] }, { "name": "Golgi associated, gamma adaptin ear containing, ARF binding protein 2", "type": "synonym", "evidence": [ { "id": "F1MKY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY0/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MKY0", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "GGA2", "url": "https://www.uniprot.org/uniprotkb/F1MKY0", "locus": { "chromosome": "25", "start_pos": 21152988, "end_pos": 21192720, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000002352", "url": "https://www.ensembl.org/id/ENSBTAG00000002352" } ] } } ], "crossref": [ { "id": "F1MKY0", "url": "https://alphafold.ebi.ac.uk/entry/F1MKY0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000002352", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000002352", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd14239", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14239", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17010", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17010", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "517031", "url": "https://www.ncbi.nlm.nih.gov/gene/517031", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013041", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013041", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027422", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027422", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038425", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038425", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:517031", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517031", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "NCCKEKK", "url": "https://omabrowser.org/oma/group/NCCKEKK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MKY0", "url": "https://www.orthodb.org/?gene=F1MKY0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45905", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45905", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45905:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45905:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00790", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00790", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF02883", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02883", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF03127", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03127", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18308", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18308", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024841188", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841188", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T3N3", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T3N3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKY0", "url": "https://www.uniprot.org/uniprotkb/F1MKY0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKY0-1", "url": "https://www.uniprot.org/uniprotkb/F1MKY0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATATAVAAGAGAAAGAESAEGPRVPTVALELWLNKATDPSMSEQDWSAIQNFCDQVNTDPNGSTYAPWLLAHKIQSPQEKEALYALTVLETCVNHCGEKFHNEVAKFRFLNELIKVLSPKYLGSWTTEKVKGRIIEILFSWTVWFPEDIKIRDAYQMLKKQGIIKQDPKLPVDKILPPPSPWPKSSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIKNLVKEEQEKSEKVSRRVSAVEEVRSHVKVLQEMLSTYRKPGQAPPDQAALQVVYERCEKLRPTLFRLASDTTDDDEALAEILQANDLLTQGVLLYKQVMEGRVTFGNTVDSSVGDIPVSRVFQNPTGCVKNCPLIDLEDSGSEQAGAVTPSLLHQDLAALGISDAPATSRVAGQNCCQEKKNPTTSALPAGGAQSPSAERNLLDLLSPQPPPGSLNYIPQKSIPKEVPPGTKSSPGWSWEAGPLAPSPSSQNTPLAQVFVPLESVKPSSLPPLIVYDRNGFRILLHFSQTGAPGHPEVQVLLLTMMSTATQPVWDIMFQVAVPKSMRVKLQPASSSKLPAFSPLTPPAVISQMLLLDNPHKEPIRLRYKLTFNQGGQPFSEVGEVKDFPDLTVLGAA", "length": 616, "header": "tr|F1MKY0-1|F1MKY0_BOVIN Isoform 1 of Golgi associated, gamma adaptin ear containing, ARF binding protein 2 OS=Bos taurus OX=9913 GN=GGA2 PE=3 SV=3 CANONICAL=F1MKY0-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T3N3-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3N3/entry", "sequence": { "sequence": "MWATTGAHDKATDPSMSEQDWSAIQNFCDQVNTDPNGSTYAPWLLAHKIQSPQEKEALYALTVLETCVNHCGEKFHNEVAKFRFLNELIKVLSPKYLGSWTTEKVKGRIIEILFSWTVWFPEDIKIRDAYQMLKKQGIIKQDPKLPVDKILPPPSPWPKSSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIKNLVKEEQEKSEKVSRRVSAVEEVRSHVKVLQEMLSTYRKPGQAPPDQAALQVVYERCEKLRPTLFRLASDTTDDDEALAEILQANDLLTQGVLLYKQVMEGRVTFGNTVDSSVGDIPVSRVFQNPTGCVKNCPLIDLEDSGSEQAGAVTPSLLHQDLAALGISDAPATSRVAGQNCCQEKKNPTTSALPAGGAQSPSAERNLLDLLSPQPPPGSLNYIPQKSIPKEVPPGTKSSPGWSWEAGPLAPSPSSQNTPLAQVFVPLESVKPSSLPPLIVYDRNGFRILLHFSQTGAPGHPEVQVLLLTMMSTATQPVWDIMFQVAVPKSMRVKLQPASSSKLPAFSPLTPPAVISQMLLLDNPHKEPIRLRYKLTFNQGGQPFSEVGEVKDFPDLTVLGAA", "length": 590, "header": "tr|A0AAA9T3N3-1|F1MKY0_BOVIN Computationally mapped isoform of Golgi associated, gamma adaptin ear containing, ARF binding protein 2 OS=Bos taurus OX=9913 GN=GGA2 PE=3 SV=1 CANONICAL=F1MKY0-1" }, "locus": { "chromosome": "25", "start_pos": 21192521, "end_pos": 21153992, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000098993.1", "url": "https://www.ensembl.org/id/ENSBTAT00000098993.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090303.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090303.1" } ] } }, { "isoform_ac": "F1MKY0-1", "url": "https://www.uniprot.org/uniprotkb/F1MKY0/entry", "sequence": { "sequence": "MATATAVAAGAGAAAGAESAEGPRVPTVALELWLNKATDPSMSEQDWSAIQNFCDQVNTDPNGSTYAPWLLAHKIQSPQEKEALYALTVLETCVNHCGEKFHNEVAKFRFLNELIKVLSPKYLGSWTTEKVKGRIIEILFSWTVWFPEDIKIRDAYQMLKKQGIIKQDPKLPVDKILPPPSPWPKSSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIKNLVKEEQEKSEKVSRRVSAVEEVRSHVKVLQEMLSTYRKPGQAPPDQAALQVVYERCEKLRPTLFRLASDTTDDDEALAEILQANDLLTQGVLLYKQVMEGRVTFGNTVDSSVGDIPVSRVFQNPTGCVKNCPLIDLEDSGSEQAGAVTPSLLHQDLAALGISDAPATSRVAGQNCCQEKKNPTTSALPAGGAQSPSAERNLLDLLSPQPPPGSLNYIPQKSIPKEVPPGTKSSPGWSWEAGPLAPSPSSQNTPLAQVFVPLESVKPSSLPPLIVYDRNGFRILLHFSQTGAPGHPEVQVLLLTMMSTATQPVWDIMFQVAVPKSMRVKLQPASSSKLPAFSPLTPPAVISQMLLLDNPHKEPIRLRYKLTFNQGGQPFSEVGEVKDFPDLTVLGAA", "length": 616, "header": "tr|F1MKY0-1|F1MKY0_BOVIN Isoform 1 of Golgi associated, gamma adaptin ear containing, ARF binding protein 2 OS=Bos taurus OX=9913 GN=GGA2 PE=3 SV=3 CANONICAL=F1MKY0-1" }, "locus": { "chromosome": "25", "start_pos": 21182419, "end_pos": 21153992, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000003035.7", "url": "https://www.ensembl.org/id/ENSBTAT00000003035.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000003035.6", "url": "https://www.ensembl.org/id/ENSBTAP00000003035.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 368, "start_aa": "Thr", "end_pos": 368, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr368", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:517031", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:517031", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0Z1L8-1", "protein_name": "Golgi associated, gamma adaptin ear containing, ARF binding protein 2", "gene_name": "GGA2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAGAEQLQRWLNEATDPGVPEENWECIQQFCAQLNADAEGPPLAARLLAHKIQSPQEVEALHALTVLETCVNNCGERFHNEIAKFRFLNELIKVLSPKYYGTWSSEKVKSRVTEIIFSWTVWFPQEVKIRDAYQMLKKQGIVKEDPKLPEDKILPPPSPRPQNSIFDTDEEKSKLLARLLKSTHAEDLQAANRLIKSMIKEEQEKSAKVSRRVNTISEVSENVKRMDELLESYKRQELPKSDYETLQNLFQRCEKLRPLLFRLASETVDDDEALAELLQANDRLTQALGRYRQTVGSHEGGGEGCSASSSSDAPAHRTPPRRMKSYTLIDFSELEAMSQPPADQFSDITSASRHSSTTSACLLEEELKSLDLSDSLVLQQPPPDFALSERELEVPLFQAAVHNGYSKNVSAFEPLELEESWEDSCLEKNEFRGLDQLSPPPRTQTLPLGLSPMKLPFPDLPNSSMADPSFSSLGYELKPAASLHPASNDASLANLFVPLISITPSSICPLTVYERDGFKAMLHFSRDPAPGRPDVLVMVLSMLSTSAQPIKDIVFQAAVPKTMKIKLQPASGTELPAFSPLLPPAVVSQVLLLANPHKDPVRLKYKLAFRHGAQPVSEVGEVTGFPGAELWGS", "length": 633 }, "evidence": [ { "id": "F1MKY0", "url": "https://omabrowser.org/oma/group/F1MKY0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "M0RAI4-1", "protein_name": "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial", "gene_name": "Ears2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAALRKSLLLAGPHVGALGHRVGRREASLGPDPGVTVRVRFAPSPTGFLHLGGLRTALYNYIFAKKHQGSFILRLEDTDQSRLVPGAAENIEDMLEWAGIPPDESPRQGGPAGPYYQSQRLALYAQATEALLKSGAAYPCFCSPQRLELLKKEALRSRQTPRYDNRCRNLSQAQVAQKLATDPKPAIRFRLEEAVPAFQDLVYGWTQHEVASVEGDPVILKSDGFPTYHLACVVDDHHMSISHVLRGSEWLVSTSKHLLLYQALGWQPPQFAHLPLLLNRDGSKLSKRQGDIFLEHFAATGFLPEALLDIITNCGSGFAENQMGRTLPELITQFDLTRITCHSALLDLEKLPEFNRLHLRRLVSSETQRPHLVEKLQGLVKEAFGSELQDRDVLDPAYMERILLLRQGHISRLQDLVSPVYSYLWTRPAVHRAELGASSEKLDVIAKHLLGLLERPGLSLTQDVVNRELKKLSEGLEGTKHSSVMKLLRMALSGQLQGPPVAEMMVSLGPEEVRERIQKPLWASHYRYLRKPEDGIGSPEAGVSDKATNPSMAEQDWSAIQKFCEQVNTDPSGPTHAPWLLAHKIQSPQEREALYALTVLEICMNHCGEKFHNEVAKFRFLNELIKVLSPKYLGAWATEKVKGRVIEILFSWTVWFPEDIKIRDAYQMLKKQGIIKQDPKLPMDKILPPPSPWPKSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIKNLVKEEQEKSEKVSRRVSAVEEVRSHVRVLREMLSMYRRPGHALPDQQALQVVYERCEKLRPTLFRLASDTTDDDDALAEILQANDLLTQGVLLYKQVVEGRVNAGNAVPAAVGAIPASRVFPSPEPCGKNCPLIDLEAPSLLHQDLAALGINDVPTRNQVVIPSCCKDKKQPGAITLMGGGIQSLSADRNLLDLFSPQPSPGPLNYVPQKSIPKEVPPGTKASPGWSWEAGPLASSPASQNTPLAHVFVPLESVKPSSLPPIIVYDRNGFRILLHFSQTGAPGHPDVQVLLLTMMSTATQPVWDVMFQVAVPKSMRVKLQPASSSKLPAFSPLTPPAVISQMLLLDNPHKEPIRLRYKLTFNQGGQPFSEVGEVKDFPDLAVLSTA", "length": 1115 }, "evidence": [ { "id": "F1MKY0", "url": "https://omabrowser.org/oma/group/F1MKY0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6P5E6-1", "protein_name": "ADP-ribosylation factor-binding protein GGA2", "gene_name": "Gga2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAATAVAAGTGSPAGTESAEGGPGAAAALELWLNKATDPSMAEQDWSAIQKFCEQVNTDPSGPTHAPWLLAHKIQSPQEKEALYALTVLEICMNHCGEKFHSEVAKFRFLNELIKVLSPKYLGAWATEKVKGRVIEILFSWTVWFPEDIKIRDAYQMLKKQGIIKQDPKLPMDKILPPPSPWPKSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIKNLVKEEQEKSEKVSRRVSAVEEVRSHVRVLREMLSMYRRPGHALPDQQALQVVYERCEKLRPTLFRLASDTTDDDDALAEILQANDLLTQGVRLYKQVVEGRVSAGNAVPAAVGAIPAPRAFPNPEPCGLNCPLIDLETPSLLHQDLAALGINDVPTRNQVVIPSCCNDKKQPGAITLMGGGIQSLSADRNLLDLFSPQPSPGLNYVPQKSIPKEVPPGTKASPGWSWEAGPLASSTASQNTPLAHVFVPLESVKPSSLPPIVVYDRNGFRILLHFSQTGAPGHPDVKVLLLTMMSTATQPVWDVMFQVAVPKSMRVKLQPASSSKLPAFSPLMPPAVISQTLLLDNPHKEPIRLRYKLTFNQGGQPFSEVGEVKDFPDLAVLSTA", "length": 603 }, "evidence": [ { "id": "F1MKY0", "url": "https://omabrowser.org/oma/group/F1MKY0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UJY4-1", "protein_name": "ADP-ribosylation factor-binding protein GGA2", "gene_name": "GGA2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAATAVAAAVAGTESAQGPPGPAASLELWLNKATDPSMSEQDWSAIQNFCEQVNTDPNGPTHAPWLLAHKIQSPQEKEALYALTVLEMCMNHCGEKFHSEVAKFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSWTVWFPEDIKIRDAYQMLKKQGIIKQDPKLPVDKILPPPSPWPKSSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIKNLVKEEQEKSEKVSKRVSAVEEVRSHVKVLQEMLSMYRRPGQAPPDQEALQVVYERCEKLRPTLFRLASDTTDDDDALAEILQANDLLTQGVLLYKQVMEGRVTFGNRVTSSLGDIPVSRVFQNPAGCMKTCPLIDLEVDNGPAQMGTVVPSLLHQDLAALGISDAPVTGMVSGQNCCEEKRNPSSSTLPGGGVQNPSADRNLLDLLSAQPAPCPLNYVSQKSVPKEVPPGTKSSPGWSWEAGPLAPSPSSQNTPLAQVFVPLESVKPSSLPPLIVYDRNGFRILLHFSQTGAPGHPEVQVLLLTMMSTAPQPVWDIMFQVAVPKSMRVKLQPASSSKLPAFSPLMPPAVISQMLLLDNPHKEPIRLRYKLTFNQGGQPFSEVGEVKDFPDLAVLGAA", "length": 613 }, "evidence": [ { "id": "F1MKY0", "url": "https://omabrowser.org/oma/group/F1MKY0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "F1MKY0", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "F1MKY0", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" } ], "pmid": "" }, { "name": "Golgi to plasma membrane protein transport", "id": "GO:0043001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043001", "evidence": [ { "database": "UniProtKB", "id": "F1MKY0", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" } ], "pmid": "" }, { "name": "protein localization to cell surface", "id": "GO:0034394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034394", "evidence": [ { "database": "UniProtKB", "id": "F1MKY0", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" } ], "pmid": "" }, { "name": "Golgi to plasma membrane transport", "id": "GO:0006893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006893", "evidence": [ { "database": "UniProtKB", "id": "F1MKY0", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "F1MKY0", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "F1MKY0", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" } ], "pmid": "" }, { "name": "clathrin-coated vesicle", "id": "GO:0030136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030136", "evidence": [ { "database": "UniProtKB", "id": "F1MKY0", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "F1MKY0", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" } ], "pmid": "" }, { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "F1MKY0", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" } ], "pmid": "" }, { "name": "ubiquitin binding", "id": "GO:0043130", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", "evidence": [ { "database": "UniProtKB", "id": "F1MKY0", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MKY0-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 616, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MKY0-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MKY0" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MKY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" }, { "id": "PS50180", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50180" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GAE", "eco_id": "ECO_0000259", "start_pos": 487, "end_pos": 608, "start_aa": "Ser", "end_aa": "Pro", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MKY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" }, { "id": "PS50909", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50909" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "GAT", "eco_id": "ECO_0000259", "start_pos": 192, "end_pos": 319, "start_aa": "Asp", "end_aa": "Glu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MKY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY0" }, { "id": "PS50179", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50179" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "VHS", "eco_id": "ECO_0000259", "start_pos": 37, "end_pos": 167, "start_aa": "Ala", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 368 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 62, "end_pos": 64 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MMX3-1", "uniprot_ac": "F1MMX3", "uniprot_id": "F1MMX3_BOVIN", "mass": { "chemical_mass": 40932.0, "monoisotopic_mass": 40932.0 }, "refseq": { "ac": "NP_001178425", "name": "proton-coupled zinc antiporter SLC30A2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178425" }, "gene_names": [ { "name": "SLC30A2", "type": "recommended", "evidence": [ { "id": "F1MMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ] }, { "name": "SLC30A2", "type": "synonym", "evidence": [ { "id": "NP_001178425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178425" } ] } ], "protein_names": [ { "name": "Proton-coupled zinc antiporter SLC30A2", "type": "recommended", "evidence": [ { "id": "F1MMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMX3/entry#names_and_taxonomy" } ] }, { "name": "Solute carrier family 30 member 2", "type": "synonym", "evidence": [ { "id": "F1MMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMX3/entry#names_and_taxonomy" } ] }, { "name": "Zinc transporter 2", "type": "synonym", "evidence": [ { "id": "F1MMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMX3/entry#names_and_taxonomy" } ] }, { "name": "proton-coupled zinc antiporter SLC30A2", "type": "synonym", "evidence": [ { "id": "NP_001178425", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178425" } ] } ], "function": [ { "annotation": "Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity. Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells. By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution.", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3#function" }, { "database": "UniProtKB", "id": "ARBA00053997", "url": "https://www.uniprot.org/uniprotkb/ARBA00053997#function" }, { "database": "UniProtKB", "id": "A0AAA9TFV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SLC30A2", "url": "https://www.uniprot.org/uniprotkb/F1MMX3", "locus": { "chromosome": "2", "start_pos": 127051091, "end_pos": 127043575, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000006355", "url": "https://www.ensembl.org/id/ENSBTAG00000006355" } ] } } ], "crossref": [ { "id": "F1MMX3", "url": "https://alphafold.ebi.ac.uk/entry/F1MMX3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000006355", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000006355", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "511061", "url": "https://www.ncbi.nlm.nih.gov/gene/511061", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002524", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002524", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027469", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027469", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027470", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027470", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050681", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050681", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR058533", "url": "https://www.ebi.ac.uk/interpro/entry/IPR058533", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511061", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511061", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GHEKMLH", "url": "https://omabrowser.org/oma/group/GHEKMLH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MMX3", "url": "https://www.orthodb.org/?gene=F1MMX3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11562", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11562:SF51", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562:SF51", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01545", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01545", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16916", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16916", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001178425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178425", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "72627", "url": "https://www.rhea-db.org/rhea/72627", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9T5B0", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5B0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T5B0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5B0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFV7", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TFV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMX3-1", "url": "https://www.uniprot.org/uniprotkb/F1MMX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKAGERMHLLDAKLAVGTYTTLWQDGTSSIPPSSPGLALQPTELAPQSSHYCHSQKGPGSHGDPKKRAWRQLCVASAFCLLFMIGEVIGGYLAHSLAIMTDAAHLLTDFASMLISLFSLWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAAERLISGDYEIKEETMLITSGCAVVVNIIMGLILHQSGHGHSRNPEHSHNASQEQGSPSVRAAFIHVIGDFLQSLGVLVAAFILYFKPEYKFIDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTAVQNLLLSVEGVEALHSLHIWALTVAQPILSVHIAIAENADAQAVLKAVSDRLQEMFHFHTMTIQIEDYSEDMKDCQSCRGPSD", "length": 375, "header": "tr|F1MMX3-1|F1MMX3_BOVIN Isoform 1 of Proton-coupled zinc antiporter SLC30A2 OS=Bos taurus OX=9913 GN=SLC30A2 PE=3 SV=2 CANONICAL=F1MMX3-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T5B0-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5B0/entry", "sequence": { "sequence": "MKAGERMHLLDAKLAVGTYTTLWQDGTSSIPPSSPGLALQPTELAPQSSHYCHSQKGPGSHGDPKKRAWRQLCVASAFCLLFMIGEVIEILGALLSVLSIWVVTGVLVYLAAERLISGDYEIKEETMLITSGCAVVVNIIMGLILHQSGHGHSRNPEHSHNASQEQGSPSVRAAFIHVIGDFLQSLGVLVAAFILYFKPEYKFIDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTAVQNLLLSVEGVEALHSLHIWALTVAQPILSVHIAIAENADAQAVLKAVSDRLQEMFHFHTMTIQIEDYSEDMKDCQSCRGPSD", "length": 326, "header": "tr|A0AAA9T5B0-1|F1MMX3_BOVIN Computationally mapped isoform of Proton-coupled zinc antiporter SLC30A2 OS=Bos taurus OX=9913 GN=SLC30A2 PE=3 SV=1 CANONICAL=F1MMX3-1" }, "locus": { "chromosome": "2", "start_pos": 127050541, "end_pos": 127043774, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099270.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099270.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000090919.1", "url": "https://www.ensembl.org/id/ENSBTAP00000090919.1" } ] } }, { "isoform_ac": "A0AAA9TFV7-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TFV7/entry", "sequence": { "sequence": "MKAGERMHLLDAKLAVGTYTTLWQDGTSSIPPSSPGLALQPTELAPQSSHYCHSQKGPGSHGDPKKRAWRQLCVASAFCLLFMIGEVIGGYLAHSLAIMTDAAHLLTDFASMLISLFSLWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAAERLISGDYEIKEETMLITSGCAVVVNIIMGLILHQSGHGHSRNPEHSHNASQEQGSPSVRAAFIHVIGDFLQSLGVLVAAFILYFKPEYKFIDPICTFLFSILVLGTTLTILRDVILVLMEGNPTDRGGWQATVNGITKSQTRLSMQDPQGCGLYSRAESAAVRGGRGSLAQPAHLGADRGPAYTVCPHRHR", "length": 353, "header": "tr|A0AAA9TFV7-1|F1MMX3_BOVIN Computationally mapped isoform of Proton-coupled zinc antiporter SLC30A2 OS=Bos taurus OX=9913 GN=SLC30A2 PE=3 SV=1 CANONICAL=F1MMX3-1" }, "locus": { "chromosome": "2", "start_pos": 127050399, "end_pos": 127043774, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000106907.2", "url": "https://www.ensembl.org/id/ENSBTAT00000106907.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095735.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095735.1" } ] } }, { "isoform_ac": "F1MMX3-1", "url": "https://www.uniprot.org/uniprotkb/F1MMX3/entry", "sequence": { "sequence": "MKAGERMHLLDAKLAVGTYTTLWQDGTSSIPPSSPGLALQPTELAPQSSHYCHSQKGPGSHGDPKKRAWRQLCVASAFCLLFMIGEVIGGYLAHSLAIMTDAAHLLTDFASMLISLFSLWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAAERLISGDYEIKEETMLITSGCAVVVNIIMGLILHQSGHGHSRNPEHSHNASQEQGSPSVRAAFIHVIGDFLQSLGVLVAAFILYFKPEYKFIDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTAVQNLLLSVEGVEALHSLHIWALTVAQPILSVHIAIAENADAQAVLKAVSDRLQEMFHFHTMTIQIEDYSEDMKDCQSCRGPSD", "length": 375, "header": "tr|F1MMX3-1|F1MMX3_BOVIN Isoform 1 of Proton-coupled zinc antiporter SLC30A2 OS=Bos taurus OX=9913 GN=SLC30A2 PE=3 SV=2 CANONICAL=F1MMX3-1" }, "locus": { "chromosome": "2", "start_pos": 127050541, "end_pos": 127043774, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037897.7", "url": "https://www.ensembl.org/id/ENSBTAT00000037897.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037719.4", "url": "https://www.ensembl.org/id/ENSBTAP00000037719.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511061", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511061", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YW77-1", "protein_name": "Proton-coupled zinc antiporter SLC30A2", "gene_name": "SLC30A2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MAAGGGEKQQLLGEGTGRSYLGMAQKHTVGSAQGQAPTLELSARHRRHCHAGGAGSDPRQQQRARRKLYVAAGICLIFMVGEAVGGYLAHSLAILTDAAHLLTDFASIMISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAAQRLLLGDYNIEGSVMLITSACAVAVNIVMGAALHQTGHGHSHGGAHEQPHTHEQPNASVRAAFVHVVGDLLQSVGVLIASYIIFFKPEYKYVDPICTFLFSVLVLGTTLTILRDVLLVLMEGTPRGMDFNAVRDTLLAVGGVEAVHSLHIWALTASQPLLSVHIAINAGADAQEVLEEASSRLQRAFRFHTTTIQIESYSEDMRDCRECQPPSD", "length": 371 }, "evidence": [ { "id": "F1MMX3", "url": "https://omabrowser.org/oma/group/F1MMX3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "I3LTT3-1", "protein_name": "Proton-coupled zinc antiporter SLC30A2", "gene_name": "SLC30A2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDLQPIELAAKSNHYCHQKGPDSPWDPKKKQAWRQLCVAAAFCLLFMIGEVIGGYLAHSLAIMTDAAHLLTDFASMLISLFSLWMSSRPATKTMNFGWQRAEILGALLSVLSIWVVTGVLVYLAVERLISGNYEIVGGTMLITSGCAVVVNIIMGFILHQSGHGHGHSHGHGHGHDHGHSDSASQHQENPSVRAAFIHVIGDFLQSLGVLVAAYILYFKPEYKYIDPICTFLFSVLVLGTTLTILRDVIVVLMEGDPKGVDFTAVRDLLLSVEGVEALHNLHIWALTVAQPVLSVHIAIARNTDAQAVLKAASACLQGKFHFHTVTIQIEDYSEDMKDCQSCQGPSA", "length": 347 }, "evidence": [ { "id": "F1MMX3", "url": "https://omabrowser.org/oma/group/F1MMX3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q2HJ10-1", "protein_name": "Proton-coupled zinc antiporter SLC30A2", "gene_name": "Slc30a2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQTMDKQNLLESTRGARSFLGSLWKSEASRIPPVDLPAVELAVQSNHYCHAQKDSGSHPDPEKQRARRKLYVASAICLVFMIGEIIGGYLAQSLAIMTDAAHLLTDFASMLISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAVQRLISGDYEIKGDTMLITSGCAVAVNLIMGLALHQSGHGHSHGNSRDDSSQQQNPSVRAAFIHVIGDLLQSVGVLVAAYIIYFKPEYKYVDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTTVKNLLLSVDGVEALHSLHIWALTVAQPVLSVHIAIAQNADAQAVLKVARDRLQGKFNFHTMTIQIEKYSEDMKNCQACQGPLE", "length": 371 }, "evidence": [ { "id": "F1MMX3", "url": "https://omabrowser.org/oma/group/F1MMX3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BRI3-2", "protein_name": "Proton-coupled zinc antiporter SLC30A2", "gene_name": "SLC30A2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEAKEKQHLLDARPAIRSYTGSLWQEGAGWIPLPRPGLDLQAIELAAQSNHHCHAQKGPDSHCDPKKGKAQRQLYVASAICLLFMIGEVVGGYLAHSLAVMTDAAHLLTDFASMLISLFSLWMSSRPATKTMNFGWQRAEILGALVSVLSIWVVTGVLVYLAVERLISGDYEIDGGTMLITSGCAVAVNIIMGLTLHQSGHGHSHGTTNQQEENPSVRAAFIHVIGDFMQSMGVLVAAYILYFKPEYKYVDPICTFVFSILVLGTTLTILRDVILVLMEGTPKGVDFTAVRDLLLSVEGVEALHSLHIWALTVAQPVLSVHIAIAQNTDAQAVLKTASSRLQGKFHFHTVTIQIEDYSEDMKDCQACQGPSD", "length": 372 }, "evidence": [ { "id": "F1MMX3", "url": "https://omabrowser.org/oma/group/F1MMX3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ZT63-1", "protein_name": "Metal tolerance protein 1", "gene_name": "MTP1", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MESSSPHHSHIVEVNVGKSDEERIIVASKVCGEAPCGFSDSKNASGDAHERSASMRKLCIAVVLCLVFMSVEVVGGIKANSLAILTDAAHLLSDVAAFAISLFSLWAAGWEATPRQTYGFFRIEILGALVSIQLIWLLTGILVYEAIIRIVTETSEVNGFLMFLVAAFGLVVNIIMAVLLGHDHGHSHGHGHGHGHDHHNHSHGVTVTTHHHHHDHEHGHSHGHGEDKHHAHGDVTEQLLDKSKTQVAAKEKRKRNINLQGAYLHVLGDSIQSVGVMIGGAIIWYNPEWKIVDLICTLAFSVIVLGTTINMIRNILEVLMESTPREIDATKLEKGLLEMEEVVAVHELHIWAITVGKVLLACHVNIRPEADADMVLNKVIDYIRREYNISHVTIQIER", "length": 398 }, "evidence": [ { "id": "F1MMX3", "url": "https://omabrowser.org/oma/group/F1MMX3/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "zinc ion transmembrane transport", "id": "GO:0071577", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071577", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "zinc ion import into organelle", "id": "GO:0062111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062111", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "response to zinc ion", "id": "GO:0010043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010043", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "zinc ion import into lysosome", "id": "GO:0140916", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140916", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "zinc ion import into mitochondrion", "id": "GO:0140917", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140917", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "monoatomic cation transmembrane transporter activity", "id": "GO:0008324", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008324", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "antiporter activity", "id": "GO:0015297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015297", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "zinc ion transmembrane transporter activity", "id": "GO:0005385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005385", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "zinc:proton antiporter activity", "id": "GO:0140826", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140826", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "zymogen granule membrane", "id": "GO:0042589", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042589", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" }, { "name": "late endosome", "id": "GO:0005770", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005770", "evidence": [ { "database": "UniProtKB", "id": "F1MMX3", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "72627", "name": "", "equation": "Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [], "evidence": [ { "id": "72627", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/72627" } ] } ], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MMX3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 375, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MMX3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MMX3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" }, { "id": "PF16916", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16916" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cation efflux protein cytoplasmic", "eco_id": "ECO_0000259", "start_pos": 285, "end_pos": 360, "start_aa": "Pro", "end_aa": "Tyr", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MMX3" }, { "id": "PF01545", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01545" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cation efflux protein transmembrane", "eco_id": "ECO_0000259", "start_pos": 73, "end_pos": 281, "start_aa": "Cys", "end_aa": "Met", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 210, "end_pos": 212 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MR82-1", "uniprot_ac": "F1MR82", "uniprot_id": "F1MR82_BOVIN", "mass": { "chemical_mass": 32979.0, "monoisotopic_mass": 32979.0 }, "refseq": { "ac": "NP_777004", "name": "pituitary-specific positive transcription factor 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" }, "gene_names": [ { "name": "POU1F1", "type": "recommended", "evidence": [ { "id": "F1MR82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MR82" } ] }, { "name": "GHF-1", "type": "synonym", "evidence": [ { "id": "NP_777004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ] }, { "name": "POU1F1", "type": "synonym", "evidence": [ { "id": "NP_777004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ] }, { "name": "Pit-1", "type": "synonym", "evidence": [ { "id": "NP_777004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ] }, { "name": "Pit1", "type": "synonym", "evidence": [ { "id": "NP_777004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ] } ], "protein_names": [ { "name": "POU domain protein", "type": "recommended", "evidence": [ { "id": "F1MR82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MR82/entry#names_and_taxonomy" } ] }, { "name": "POU domain, class 1, transcription factor 1", "type": "synonym", "evidence": [ { "id": "NP_777004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ] }, { "name": "growth hormone factor 1", "type": "synonym", "evidence": [ { "id": "NP_777004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ] }, { "name": "growth hormone factor I", "type": "synonym", "evidence": [ { "id": "NP_777004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ] }, { "name": "pituitary growth factor", "type": "synonym", "evidence": [ { "id": "NP_777004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ] }, { "name": "pituitary-specific positive transcription factor 1", "type": "synonym", "evidence": [ { "id": "NP_777004", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ] } ], "function": [ { "annotation": "Homozygote genotypes of GH (LL) and beta-LG (AA) were superior compared to heterozygote genotypes, whereas, the heterozygote genotype of Pit-1 gene (AB) was desirable", "evidence": [ { "database": "RefSeq", "id": "NP_777004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" }, { "database": "PubMed", "id": "22730770", "url": "https://glygen.org/publication/PubMed/22730770" } ] }, { "annotation": "No significant associations of the TaqI polymorphism of the bovine POU1F1 gene with body weight and average daily gain for different growth periods were observed.", "evidence": [ { "database": "RefSeq", "id": "NP_777004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" }, { "database": "PubMed", "id": "18431643", "url": "https://glygen.org/publication/PubMed/18431643" } ] }, { "annotation": "Results showed that GC genotype at 1178 locus of POU1F1 gene was advantageous for milk yield, milk protein yield, and milk fat yield", "evidence": [ { "database": "RefSeq", "id": "NP_777004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" }, { "database": "PubMed", "id": "22207382", "url": "https://glygen.org/publication/PubMed/22207382" } ] }, { "annotation": "The POU1F1 gene is associated with economically important traits in dairy cattle; an SNP in exon 3 of POU1F1 that changes a proline to a histidine was identified.", "evidence": [ { "database": "RefSeq", "id": "NP_777004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" }, { "database": "PubMed", "id": "18557974", "url": "https://glygen.org/publication/PubMed/18557974" } ] }, { "annotation": "The association of IGF1, GH, and PIT1 markers with growth and reproductive traits were assessed.", "evidence": [ { "database": "RefSeq", "id": "NP_777004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" }, { "database": "PubMed", "id": "25258122", "url": "https://glygen.org/publication/PubMed/25258122" } ] }, { "annotation": "The effect of miR-23b-3p on regulating GH by targeting POU1F1 in Yanbian yellow cattle.", "evidence": [ { "database": "RefSeq", "id": "NP_777004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" }, { "database": "PubMed", "id": "38739483", "url": "https://glygen.org/publication/PubMed/38739483" } ] }, { "annotation": "Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.", "evidence": [ { "database": "UniProtKB", "id": "F1MR82", "url": "https://www.uniprot.org/uniprotkb/F1MR82#function" }, { "database": "UniProtKB", "id": "ARBA00058993", "url": "https://www.uniprot.org/uniprotkb/ARBA00058993#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MR82", "url": "https://www.uniprot.org/uniprotkb/F1MR82" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "POU1F1", "url": "https://www.uniprot.org/uniprotkb/F1MR82", "locus": { "chromosome": "1", "start_pos": 35417574, "end_pos": 35435629, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000009128", "url": "https://www.ensembl.org/id/ENSBTAG00000009128" } ] } } ], "crossref": [ { "id": "F1MR82", "url": "https://alphafold.ebi.ac.uk/entry/F1MR82", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000009128", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000009128", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "282315", "url": "https://www.ncbi.nlm.nih.gov/gene/282315", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010982", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010982", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013847", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013847", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050255", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050255", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:282315", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282315", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TSHAHGM", "url": "https://omabrowser.org/oma/group/TSHAHGM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MR82", "url": "https://www.orthodb.org/?gene=F1MR82", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11636", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11636", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11636:SF84", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11636:SF84", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00157", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00157", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_777004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T672", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T672", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T672-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T672-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MR82", "url": "https://www.uniprot.org/uniprotkb/F1MR82", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MR82-1", "url": "https://www.uniprot.org/uniprotkb/F1MR82-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSCQPFTSTDTFIPLNSESSATLPLIMHPSAAECLPVSNHATNVMSTATGLHYSVPSCHYGNQSSTYGVMAGSLTPCLYKFPDHTLSHGFPPMHQPLLSEDPTAADFKQELRRKSKLVEEPIDMDSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISIAAKDALERHFGEQNKPSSQEILRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFTISKEHLECR", "length": 291, "header": "tr|F1MR82-1|F1MR82_BOVIN Isoform 1 of POU domain protein OS=Bos taurus OX=9913 GN=POU1F1 PE=3 SV=1 CANONICAL=F1MR82-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T672-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T672/entry", "sequence": { "sequence": "MSCQPFTSTDTFIPLNSESSATLPLIMHPSAAECLPVSNHATNVMSTATGLHYSVPSCHYGNQSSTYGVMAGSLTPCLYKFPDHTLSHGFPPMHQPLLSEDPTAADFKQELRRKSKLVEEPIDMDSPEIRELEKFANEFKVRRIKLVLLLKTPWRDTLENRISLPLRRSC", "length": 170, "header": "tr|A0AAA9T672-1|F1MR82_BOVIN Computationally mapped isoform of POU domain protein OS=Bos taurus OX=9913 GN=POU1F1 PE=3 SV=1 CANONICAL=F1MR82-1" }, "locus": { "chromosome": "1", "start_pos": 35435540, "end_pos": 35420023, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000131443.1", "url": "https://www.ensembl.org/id/ENSBTAT00000131443.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000094262.1", "url": "https://www.ensembl.org/id/ENSBTAP00000094262.1" } ] } }, { "isoform_ac": "F1MR82-1", "url": "https://www.uniprot.org/uniprotkb/F1MR82/entry", "sequence": { "sequence": "MSCQPFTSTDTFIPLNSESSATLPLIMHPSAAECLPVSNHATNVMSTATGLHYSVPSCHYGNQSSTYGVMAGSLTPCLYKFPDHTLSHGFPPMHQPLLSEDPTAADFKQELRRKSKLVEEPIDMDSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISIAAKDALERHFGEQNKPSSQEILRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFTISKEHLECR", "length": 291, "header": "tr|F1MR82-1|F1MR82_BOVIN Isoform 1 of POU domain protein OS=Bos taurus OX=9913 GN=POU1F1 PE=3 SV=1 CANONICAL=F1MR82-1" }, "locus": { "chromosome": "1", "start_pos": 35435540, "end_pos": 35419886, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000056643.3", "url": "https://www.ensembl.org/id/ENSBTAT00000056643.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000050905.2", "url": "https://www.ensembl.org/id/ENSBTAP00000050905.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 103, "start_aa": "Thr", "end_pos": 103, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr103", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "A TaqI PCR-RFLP detecting a novel SNP in exon 2 of the bovine POU1F1 gene.", "journal": "Biochemical genetics", "date": "2008-08", "authors": "Pan Chuanying, Lan Xianyong, Chen Hong, Guo Yikun, Shu Jianhong, Lei Chuzhao, Wang Xinzhuang", "evidence": [ { "database": "RefSeq", "id": "NP_777004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ], "reference": [ { "type": "PubMed", "id": "18431643", "url": "https://glygen.org/publication/PubMed/18431643" } ] }, { "title": "A proline-to-histidine mutation in POU1F1 is associated with production traits in dairy cattle.", "journal": "Animal genetics", "date": "2008-10", "authors": "Huang W, Maltecca C, Khatib H", "evidence": [ { "database": "RefSeq", "id": "NP_777004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ], "reference": [ { "type": "PubMed", "id": "18557974", "url": "https://glygen.org/publication/PubMed/18557974" } ] }, { "title": "[Polymorphism of POU1F1 gene and PRL gene and their combined effects on milk performance traits in Chinese Holstein cattle].", "journal": "Yi chuan = Hereditas", "date": "2011-12", "authors": "Jia Xiang-Jie, Wang Chang-Fa, Yang Gui-Wen, Huang Jin-Ming, Li Qiu-Ling, Zhong Ji-Feng", "evidence": [ { "database": "RefSeq", "id": "NP_777004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ], "reference": [ { "type": "PubMed", "id": "22207382", "url": "https://glygen.org/publication/PubMed/22207382" } ] }, { "title": "Effect of polymorphic variants of GH, Pit-1, and beta-LG genes on milk production of Holstein cows.", "journal": "Genetika", "date": "2012-04", "authors": "Heidari M, Azari M A, Hasani S, Khanahmadi A, Zerehdaran S", "evidence": [ { "database": "RefSeq", "id": "NP_777004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ], "reference": [ { "type": "PubMed", "id": "22730770", "url": "https://glygen.org/publication/PubMed/22730770" } ] }, { "title": "Effect of IGF1, GH, and PIT1 markers on the genetic parameters of growth and reproduction traits in Canchim cattle.", "journal": "Molecular biology reports", "date": "2015-01", "authors": "Grossi Daniela do Amaral, Buzanskas Marcos Eli, Grupioni Natalia Vinhal, de Paz Claudia Cristina Paro, Regitano Luciana Correia de Almeida, de Alencar Maur\u00edcio Mello, Schenkel Fl\u00e1vio Schramm, Munari Dan\u00edsio Prado", "evidence": [ { "database": "RefSeq", "id": "NP_777004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ], "reference": [ { "type": "PubMed", "id": "25258122", "url": "https://glygen.org/publication/PubMed/25258122" } ] }, { "title": "The effect of miR-23b-3p on regulating GH by targeting POU1F1 in Yanbian yellow cattle.", "journal": "Animal biotechnology", "date": "2024-11", "authors": "Xu Lu, Jin Taihua, Lou Angang, Guan Jiuyang, Zhang Xinglin, Wang Hui, Guan Lizeng", "evidence": [ { "database": "RefSeq", "id": "NP_777004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777004" } ], "reference": [ { "type": "PubMed", "id": "38739483", "url": "https://glygen.org/publication/PubMed/38739483" } ] } ], "pathway": [ { "id": "bta:282315", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:282315", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A061I6V5-1", "protein_name": "POU domain protein", "gene_name": "Pou1f1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MSCQSFTSADTFIPLNSDAPATLPLIMHHSAAECLPVSNHATNVMSTVPSILSLIQTPNCLHTYFSVTTMGNTATGLHYSVPSCHYGNQPSTYGVMAGGLTPCLYKFPDHTLSHGFPPLHQPLLAEDPTASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYSEKVGANERKRKRRTTISIAAKDALERHFGQQSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR", "length": 317 }, "evidence": [ { "id": "F1MR82", "url": "https://omabrowser.org/oma/group/F1MR82/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P10037-1", "protein_name": "Pituitary-specific positive transcription factor 1", "gene_name": "Pou1f1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSCQPFTSADTFIPLNSDASAALPLRMHHSAAEGLPASNHATNVMSTATGLHYSVPSCHYGNQPSTYGVMAGTLTPCLYKFPDHTLSHGFPPLHQPLLAEDPTASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR", "length": 291 }, "evidence": [ { "id": "F1MR82", "url": "https://omabrowser.org/oma/group/F1MR82/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P28069-1", "protein_name": "Pituitary-specific positive transcription factor 1", "gene_name": "POU1F1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSCQAFTSADTFIPLNSDASATLPLIMHHSAAECLPVSNHATNVMSTATGLHYSVPSCHYGNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPIHQPLLAEDPTAADFKQELRRKSKLVEEPIDMDSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISIAAKDALERHFGEQNKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR", "length": 291 }, "evidence": [ { "id": "F1MR82", "url": "https://omabrowser.org/oma/group/F1MR82/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q00286-1", "protein_name": "Pituitary-specific positive transcription factor 1", "gene_name": "Pou1f1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSCQSFTSADTFITLNSDASAALPLRMHHSAAECLPASNHATNVMSTATGLHYSVPSCHYGNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPLHQPLLAEDPAASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISVAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR", "length": 291 }, "evidence": [ { "id": "F1MR82", "url": "https://omabrowser.org/oma/group/F1MR82/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MR82", "url": "https://www.uniprot.org/uniprotkb/F1MR82" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MR82", "url": "https://www.uniprot.org/uniprotkb/F1MR82" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MR82", "url": "https://www.uniprot.org/uniprotkb/F1MR82" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MR82", "url": "https://www.uniprot.org/uniprotkb/F1MR82" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1MR82", "url": "https://www.uniprot.org/uniprotkb/F1MR82" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1MR82", "url": "https://www.uniprot.org/uniprotkb/F1MR82" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1MR82", "url": "https://www.uniprot.org/uniprotkb/F1MR82" } ], "pmid": "" }, { "name": "RNA polymerase II-specific DNA-binding transcription factor binding", "id": "GO:0061629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061629", "evidence": [ { "database": "UniProtKB", "id": "F1MR82", "url": "https://www.uniprot.org/uniprotkb/F1MR82" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 62, "end_pos": 64, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MR82-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 291, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MR82-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MR82" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MR82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MR82" }, { "id": "PS50071", "database": "PROSITE", "url": 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Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001193664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193664" }, { "database": "PubMed", "id": "20156197", "url": "https://glygen.org/publication/PubMed/20156197" } ] }, { "annotation": "Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. 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"evidence": [ { "database": "UniProtKB", "id": "F1ML75", "url": "https://www.uniprot.org/uniprotkb/F1ML75" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "IL1R1", "url": "https://www.uniprot.org/uniprotkb/F1ML75", "locus": { "chromosome": "11", "start_pos": 6915249, "end_pos": 6876050, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005273", "url": "https://www.ensembl.org/id/ENSBTAG00000005273" } ] } } ], "crossref": [ { "id": "F1ML75", "url": "https://alphafold.ebi.ac.uk/entry/F1ML75", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005273", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005273", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "515640", "url": "https://www.ncbi.nlm.nih.gov/gene/515640", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000157", "url": 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Classification" ] }, { "id": "IPR035897", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035897", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041416", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041416", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:515640", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515640", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HMPAQRQ", "url": "https://omabrowser.org/oma/group/HMPAQRQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1ML75", "url": "https://www.orthodb.org/?gene=F1ML75", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11890", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11890", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11890:SF26", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11890:SF26", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01582", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01582", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13895", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13895", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18452", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18452", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9020702", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020702", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001193664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193664", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9T7H5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7H5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9T7H5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7H5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML75", "url": "https://www.uniprot.org/uniprotkb/F1ML75", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML75-1", "url": "https://www.uniprot.org/uniprotkb/F1ML75-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKVLLRLLCFMTLLIPSLEADKCEEHEEKITLVSPAREIDARSCPLITSAHKEPITWYKNDSTTPVSTERGSRIHQHKDKLWFVPAEVEDSGAYYCSVRNSTYCLKIKIVVEFVQHEPNLCYNERTVFTQRLLTAGDGQLVCPYLDFLKDENNELPQVQWYKDCKPLLLDNVNFAGVTNKLIITNVNTAHSGHYMCHASYTHLGKQYRVTRAIKLITLEKSRNTKPEIVSPANETMEVVLGSWLQLICNVTGRLSNYVYWKWNGSMVSTYTPVLEEDFITVENPLNRRRSTVLARLNISAVESKFFLHPFTCLAKNTEGISTAYIQLIHPVPDFQKPTVGIFVMLTLVITCSVCIYKVFKVDIVLWYRDSFYDFLPKKVSDGKTYDAYILCPKTPGEGSTCNSDIFVFKVMPEVLEKQCGYKLFICGRDDYVGESIVEVVNENVKKSRRLIIILVPETSGFSWPGNSSEEQVAMYNALIQEGIKVVLLELEKIPDYEKMPESIKFIKQKQGVIRWSGDFREGSQSMNSRFWKKVRYHMPVQRQRRLSKHQLLSPATLLDSKEKRPMEVHVPLG", "length": 573, "header": "tr|F1ML75-1|F1ML75_BOVIN Isoform 1 of Interleukin-1 receptor type 1 OS=Bos taurus OX=9913 GN=IL1R1 PE=3 SV=3 CANONICAL=F1ML75-1" }, "isoforms": [ { "isoform_ac": "A0AAA9T7H5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7H5/entry", "sequence": { "sequence": "MPANLENSAVATGLEKENMKVLLRLLCFMTLLIPSLEADKCEEHEEKITLVSPAREIDARSCPLITSAHKEPITWYKNDSTTPVSTERGSRIHQHKDKLWFVPAEVEDSGAYYCSVRNSTYCLKIKIVVEFVQHEPNLCYNERTVFTQRLLTAGDGQLVCPYLDFLKDENNELPQVQWYKDCKPLLLDNVNFAGVTNKLIITNVNTAHSGHYMCHASYTHLGKQYRVTRAIKLITLEKSRNTKPEIVSPANETMEVVLGSWLQLICNVTGRLSNYVYWKWNGSMVSTYTPVLEEDFITVENPLNRRRSTVLARLNISAVESKFFLHPFTCLAKNTEGISTAYIQLIHPVPDFQKPTVGIFVMLTLVITCSVCIYKVFKVDIVLWYRDSFYDFLPKKVSDGKTYDAYILCPKTPGEGSTCNSDIFVFKVMPEVLEKQCGYKLFICGRDDYVGESIVEVVNENVKKSRRLIIILVPETSGFSWPGNSSEEQVAMYNALIQEGIKVVLLELEKIPDYEKMPESIKFIKQKQGVIRWSGDFREGSQSMNSRFWKKVRYHMPVQRQRRLSKHQLLSPATLLDSKEKRPMEVHVPLG", "length": 591, "header": "tr|A0AAA9T7H5-1|F1ML75_BOVIN Computationally mapped isoform of Interleukin-1 receptor type 1 OS=Bos taurus OX=9913 GN=IL1R1 PE=3 SV=1 CANONICAL=F1ML75-1" }, "locus": { "chromosome": "11", "start_pos": 6913548, "end_pos": 6881970, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000120063.1", "url": 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SV=3 CANONICAL=F1ML75-1" }, "locus": { "chromosome": "11", "start_pos": 6913548, "end_pos": 6885930, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006938.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006938.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006938.6", "url": "https://www.ensembl.org/id/ENSBTAP00000006938.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 210, "start_aa": "Thr", "end_pos": 210, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr210", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], 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Peynot Nathalie, Giraud-Delville Corinne, Caama\u00f1o Jos\u00e9 N\u00e9stor, Sandra Olivier, Duranthon V\u00e9ronique, Mu\u00f1oz Marta", "evidence": [ { "database": "RefSeq", "id": "NP_001193664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193664" } ], "reference": [ { "type": "PubMed", "id": "25955718", "url": "https://glygen.org/publication/PubMed/25955718" } ] } ], "pathway": [ { "id": "bta:515640", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515640", "resource": "KEGG Pathway" }, { "id": "R-BTA-9020702", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9020702", "resource": "Reactome", "description": "Interleukin-1 signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2QSI4-1", "protein_name": "Interleukin-1 receptor type 1", "gene_name": "IL1R1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": 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"length": 1203, "header": "tr|A0AAA9T9P7-1|F1MMW5_BOVIN Computationally mapped isoform of Protocadherin 9 OS=Bos taurus OX=9913 GN=PCDH9 PE=4 SV=1 CANONICAL=F1MMW5-1" }, "locus": { "chromosome": "12", "start_pos": 40601502, "end_pos": 39462059, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000093828.1", "url": "https://www.ensembl.org/id/ENSBTAT00000093828.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000093360.1", "url": "https://www.ensembl.org/id/ENSBTAP00000093360.1" } ] } }, { "isoform_ac": "F1MMW5-1", "url": "https://www.uniprot.org/uniprotkb/F1MMW5/entry", "sequence": { "sequence": 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taurus OX=9913 GN=NEU3 PE=3 SV=1 CANONICAL=F1MRJ3-1" }, "locus": { "chromosome": "15", "start_pos": 54266512, "end_pos": 54258107, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000154404.1", "url": "https://www.ensembl.org/id/ENSBTAT00000154404.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000104354.1", "url": "https://www.ensembl.org/id/ENSBTAP00000104354.1" } ] } }, { "isoform_ac": "F1MRJ3-1", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3/entry", "sequence": { "sequence": "MEEPGFPAEVMEEVTSCSFSSPLFQQEDKRGVTYRIPALIYVPPAHTFLAFAEKRSSSKDEDALHLVLRRGLRTGQSVQWEPLKSLMKATLPGHRTMNPCPVWERKSGYVYLFFICVQGHVTERQQIMSGRNAARLCFICSQDAGYSWSDVRDLTEEVIGPEVTHWATFAVGPGHGIQLQSGRLIIPAYAYYIPFWFFCFRLPYRARPHSLMIYSDDLGATWHHGRLIKPMVTVECEVAEVIGKAGHPVLYCSARTPNRHRAEALSIDHGECFQKPVLSHQLCEPPHGCQGSVVSFCPLEIPGGCQNLAGEDAPAIQQSPLLCSSVRPEPEAGTLSESWLLYSHPTNKKRRVDLGIYLNQSPLEAACWSRPWILHCGPCGYSDLAALENEGLFGCLFECGTKQECEQIAFRLFTDREILSHVQGDCSTPGMNSEPSKK", "length": 438, "header": "tr|F1MRJ3-1|F1MRJ3_BOVIN Isoform 1 of exo-alpha-sialidase OS=Bos taurus OX=9913 GN=NEU3 PE=3 SV=2 CANONICAL=F1MRJ3-1" }, "locus": { "chromosome": "15", "start_pos": 54266512, "end_pos": 54253669, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000036738.6", "url": "https://www.ensembl.org/id/ENSBTAT00000036738.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000036593.4", "url": "https://www.ensembl.org/id/ENSBTAP00000036593.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 428, "start_aa": "Thr", "end_pos": 428, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr428", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-4085001", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-4085001", "resource": "Reactome", "description": "Sialic acid metabolism" }, { "id": "R-BTA-9840310", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9840310", "resource": "Reactome", "description": "Glycosphingolipid catabolism" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "lipid catabolic process", "id": "GO:0016042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "F1MRJ3", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3" } ], "pmid": "" }, { "name": "ganglioside catabolic process", "id": "GO:0006689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006689", "evidence": [ { "database": "UniProtKB", "id": "F1MRJ3", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3" } ], "pmid": "" }, { "name": "positive regulation of epidermal growth factor receptor signaling pathway", "id": "GO:0045742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045742", "evidence": [ { "database": "UniProtKB", "id": "F1MRJ3", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3" } ], "pmid": "" }, { "name": "oligosaccharide catabolic process", "id": "GO:0009313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009313", "evidence": [ { "database": "UniProtKB", "id": "F1MRJ3", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3" } ], "pmid": "" }, { "name": "negative regulation of clathrin-dependent endocytosis", "id": "GO:1900186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900186", "evidence": [ { "database": "UniProtKB", "id": "F1MRJ3", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "exo-alpha-sialidase activity", "id": "GO:0004308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004308", "evidence": [ { "database": "UniProtKB", "id": "F1MRJ3", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MRJ3", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MRJ3", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "F1MRJ3", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "F1MRJ3", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3" } ], "pmid": "" }, { "name": "recycling endosome membrane", "id": "GO:0055038", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055038", "evidence": [ { "database": "UniProtKB", "id": "F1MRJ3", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MRJ3", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MRJ3", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "F1MRJ3", "url": "https://www.uniprot.org/uniprotkb/F1MRJ3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 359, "end_pos": 361, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-1605768", "name": "NEU3 cleaves GM3 to form LacCer (plasma membrane)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-ALL-1605649" ], "output_participant_list": [ "R-ALL-1605618" ], "enzyme_list": [ "F1MRJ3-1" ], "evidence": [ { "id": "R-BTA-1605768", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1605768" } ] }, { "id": "R-BTA-4084994", "name": "NEU3 hydrolyzes Neu5Ac from glycoconjugates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. 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"MRGPYWKCASRRSCIFNMECMFGPVLWSWPSTCGFTEDLCQIGAGVSLPGIVAAKCGAEVTLSDSSELPHCLAICRESCQMNNLPQVHVVGLTWGHVSRDLLALPPQDIILASDVFFEPEDFEDILTTVYFLMQKNPKVKLWSTYQVRSADWSLEALLYKWDMKCVHIPLESFGADKEDIAESALPGRHTVEMLVISFAKDNLNYT", "length": 206, "header": "tr|A0AAA9TGB9-1|F1MQ97_BOVIN Computationally mapped isoform of Histone-arginine methyltransferase METTL23 OS=Bos taurus OX=9913 GN=METTL23 PE=3 SV=1 CANONICAL=F1MQ97-1" }, "locus": { "chromosome": "19", "start_pos": 55051975, "end_pos": 55046999, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133867.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133867.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000095916.1", "url": "https://www.ensembl.org/id/ENSBTAP00000095916.1" } ] } }, { "isoform_ac": "F1MQ97-1", "url": "https://www.uniprot.org/uniprotkb/F1MQ97/entry", "sequence": { "sequence": 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[], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "methyltransferase activity", "id": "GO:0008168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168", "evidence": [ { "database": "UniProtKB", "id": "F1MQ97", "url": "https://www.uniprot.org/uniprotkb/F1MQ97" } ], "pmid": "" }, { "name": "protein-arginine omega-N asymmetric methyltransferase activity", "id": "GO:0035242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035242", "evidence": [ { "database": "UniProtKB", "id": "F1MQ97", "url": "https://www.uniprot.org/uniprotkb/F1MQ97" } ], "pmid": "" }, { "name": "histone H3R17 methyltransferase activity", "id": "GO:0035642", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035642", "evidence": [ { "database": "UniProtKB", "id": "F1MQ97", "url": "https://www.uniprot.org/uniprotkb/F1MQ97" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "methylation", "id": 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{ "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MQ97", "url": "https://www.uniprot.org/uniprotkb/F1MQ97" } ], "pmid": "" }, { "name": "female pronucleus", "id": "GO:0001939", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001939", "evidence": [ { "database": "UniProtKB", "id": "F1MQ97", "url": "https://www.uniprot.org/uniprotkb/F1MQ97" } ], "pmid": "" }, { "name": "male pronucleus", "id": "GO:0001940", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001940", "evidence": [ { "database": "UniProtKB", "id": "F1MQ97", "url": "https://www.uniprot.org/uniprotkb/F1MQ97" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "48096", "name": "", "equation": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 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"strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000110952.1", "url": "https://www.ensembl.org/id/ENSBTAT00000110952.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097363.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097363.1" } ] } }, { "isoform_ac": "F1MPL1-1", "url": "https://www.uniprot.org/uniprotkb/F1MPL1/entry", "sequence": { "sequence": "MAETASPLKHFVLAKKTITAIFDQLLEFVTEGSHFVEATYKNPELDRVATEDDLIEIQRYKNKLSVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGSDEKRSVKTVNQLAHALHMDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKQFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELRVVDPLEARNRIFFVSAKEVLSARKHKAQGMPEGGGALAEGFQARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILETVKNIMDSINVAAAEKRVYSIEEREDQIDRLDFIRNQMNLLTLDVKKKIREVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPTPSVLKVYKNELNKHIEDGMGRNLADRCTNEVNASMLQSQQEIIENLKPLLPAGIQNKLHTLVPCKKFDLSYDLNCHKLCSDFQEDIVFRFSLGWASLVHRFLGPTNAQRVLLGLSEPIFQLPRSLASTPTAPSNPATPDNASQEELMVTLITTLASLTSRTSMGIIVVGGVIWKTVGWKLISVSLSMYGALYLYERLTWTTRAKERAFKQQFVNYATEKLQMIVSFTSANCSHQVQQEMATTFARLCQQVDITQRHLEEEIARLSKEIDQLEKIQNNSKLLRNKAVQLENQLENFTKRFLHSSREEES", "length": 742, "header": "tr|F1MPL1-1|F1MPL1_BOVIN Isoform 1 of Mitofusin 1 OS=Bos taurus OX=9913 GN=MFN1 PE=4 SV=3 CANONICAL=F1MPL1-1" }, "locus": { "chromosome": "1", "start_pos": 87762012, "end_pos": 87721736, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013860.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013860.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013860.6", "url": "https://www.ensembl.org/id/ENSBTAP00000013860.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 571, "start_aa": "Thr", "end_pos": 571, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr571", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "High expression of Mfn1 promotes early development of bovine SCNT embryos: improvement of mitochondrial membrane potential and oxidative metabolism.", "journal": "Mitochondrion", "date": "2012-03", "authors": "Hua Song, Zhang Hui, Song Yakun, Li Ruizhe, Liu Jun, Wang Yongsheng, Quan Fusheng, Zhang Yong", "evidence": [ { "database": "RefSeq", "id": "NP_001193437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193437" } ], "reference": [ { "type": "PubMed", "id": "22245982", "url": "https://glygen.org/publication/PubMed/22245982" } ] }, { "title": "The relationship between MFN1 copy number variation and growth traits of beef cattle.", "journal": "Gene", "date": "2022-02-15", "authors": "Yao Zhi, Li Jiaxiao, Zhang Zijing, Chai Yanan, Liu Xian, Li Jungang, Huang Yajun, Li Lijuan, Huang Weihong, Yang Guojie, Chen Fuying, Shi Qiaoting, Ru Baorui, Lei Chuzhao, Wang Eryao, Huang Yongzhen", "evidence": [ { "database": "RefSeq", "id": "NP_001193437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193437" } ], "reference": [ { "type": "PubMed", "id": "34864096", "url": "https://glygen.org/publication/PubMed/34864096" } ] } ], "pathway": [ { "id": "bta:515180", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:515180", "resource": "KEGG Pathway" }, { "id": "R-BTA-5205685", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5205685", "resource": "Reactome", "description": "PINK1-PRKN Mediated Mitophagy" }, { "id": "R-BTA-9013419", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9013419", "resource": "Reactome", "description": "RHOT2 GTPase cycle" }, { "id": "R-BTA-983231", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-983231", "resource": "Reactome", "description": "Factors involved in megakaryocyte development and platelet production" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A9J7F5F1-1", "protein_name": "Mitofusin-1 isoform X1", "gene_name": "Mfn1", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAETVSPLKHFVLAKKAITAIFGQLLEFVTEGSHFVEATYRNPELDRVATEDDLVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSPGTDVTTEMDTWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVTPLEARNRIFFVSAKEVLNSRKHKAQGMPEGGGALAEGFQARLQEFQNFEKTFEECISQSAVKTKFEQHTIRAKQILDTVKNILDSVNVAAAEKRVYSMEEREDQIDRLDFIRNQMNLLTLDVKKKIKQVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPTPSVLKVYKSELNKHIEDGMGRNLADRCTNEVNASMLQSQQEIIENLKPLLPAGIQNKLHALIPCKKFDLSYDLNFHKLCSDFQEDIVFRFSLGWSSLVHRFLGSSNAQRVLLGLSEPVFQLPRSLASTPTAPPNPAAPDNAAQEELMITLITGLASLTSRTSMGIIVVGGVIWKTVGWKLISVSLSMYGALYLYERLTWTNRAKERAFKQQFVNYATEKLQMIVSFTSANCSYQVQQEMATTFARLCQQVDVTQKHLEEEIARLSKEIDQLEKIQNNSKLLRNKAVQLESELENFSKQFLHPSNEES", "length": 741 }, "evidence": [ { "id": "F1MPL1", "url": "https://omabrowser.org/oma/group/F1MPL1/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q811U4-1", "protein_name": "Mitofusin-1", "gene_name": "Mfn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAETVSPLKHFVLAKKAITAIFGQLLEFVTEGSHFVEATYRNPELDRIASEDDLVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSPGTDVTTELDIWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVSPSEARNRIFFVSAKEVLNSRKHKAQGMPEGGGALAEGFQARLQEFQNFEQTFEECISQSAVKTKFEQHTIRAKQILDTVKNILDSVNVAAAEKRVYSMEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPTPSVLKVYKSELNKHIEDGMGRNLADRCTNEVNASILQSQQEIIENLKPLLPAGIQNKLHTLIPCKKFDLSYDLNCHKLCSDFQEDIVFRFSLGWSSLVHRFLGSTNAQRVLLGLSEPIFQVPRSLASTPTAPSNPAAPDNAAQEELMITLITGLASLTSRTSMGIIVVGGVIWKTVGWKLISVTLSMYGALYLYERLTWTTRAKERAFKQQFVNYATEKLQMIVSFTSANCSHQVQQEMATTFARLCQQVDVTQKHLEEEIARLSKEIDQLEKIQNNSKLLRNKAVQLESELENFSKQFLHPSSGES", "length": 741 }, "evidence": [ { "id": "F1MPL1", "url": "https://omabrowser.org/oma/group/F1MPL1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IWA4-1", "protein_name": "Mitofusin-1", "gene_name": "MFN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAEPVSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQEIIENLKPLLPAGIQDKLHTLIPCKKFDLSYNLNYHKLCSDFQEDIVFRFSLGWSSLVHRFLGPRNAQRVLLGLSEPIFQLPRSLASTPTAPTTPATPDNASQEELMITLVTGLASVTSRTSMGIIIVGGVIWKTIGWKLLSVSLTMYGALYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSSTSANCSHQVKQQIATTFARLCQQVDITQKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFLPSSNEES", "length": 741 }, "evidence": [ { "id": "F1MPL1", "url": "https://omabrowser.org/oma/group/F1MPL1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R4Z9-1", "protein_name": "Mitofusin-1", "gene_name": "Mfn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAETVSPLKHFVLAKKAITAIFGQLLEFVTEGSHFVEATYRNPELDRIATEDDLVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSPGTDVTTELDIWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVSPLEARNRIFFVSAKEVLNSRMNKAQGMPEGGGALAEGFQARLQEFQNFEQTFEECISQSAVKTKFEQHTIRAKQILDTVKNILDSVNVAAAEKRVYSMEEREDQIDRLDFIRNQMNLLTMDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPTPSVLKVYKSELNKHIEDGMGRNLADRCTSEVNASILQSQQEIIENLKPLLPAGIQNKLHTLIPCKKFDLSYDLNCHKLCSDFQEDIVFRFSLGWSSLVHRFLGSTNAQRVLLGLSEPIFQVPRSLASTPTAPSNPAAPDNAAQEELMITLITGLASLTSRTSMGIIVVGGVIWKTVGWKLISVTLSMYGALYLYERLTWTTRAKERAFKQQFVNYATEKLQMIVKFTSANCSHQVQQEMATTFARLCQQVDVTQKHLEEEIARLSKEIDQLEKIQNNSKLLRNKAVQLERELENFSKQFLHPSSGES", "length": 741 }, "evidence": [ { "id": "F1MPL1", "url": "https://omabrowser.org/oma/group/F1MPL1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "F1MPL1", "url": "https://www.uniprot.org/uniprotkb/F1MPL1" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "F1MPL1", "url": "https://www.uniprot.org/uniprotkb/F1MPL1" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1MPL1", "url": "https://www.uniprot.org/uniprotkb/F1MPL1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "F1MPL1", "url": "https://www.uniprot.org/uniprotkb/F1MPL1" } ], "pmid": "" }, { "name": "outer mitochondrial membrane protein complex", "id": "GO:0098799", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098799", "evidence": [ { "database": "UniProtKB", "id": "F1MPL1", "url": "https://www.uniprot.org/uniprotkb/F1MPL1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mitochondrial fusion", "id": "GO:0008053", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008053", "evidence": [ { "database": "UniProtKB", "id": "F1MPL1", "url": "https://www.uniprot.org/uniprotkb/F1MPL1" } ], "pmid": "" }, { "name": "positive regulation of mitochondrial membrane potential", "id": "GO:0010918", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010918", "evidence": [ { "database": "UniProtKB", "id": "F1MPL1", "url": "https://www.uniprot.org/uniprotkb/F1MPL1" } ], "pmid": "" }, { "name": "GTP metabolic process", "id": "GO:0046039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046039", "evidence": [ { "database": "UniProtKB", "id": "F1MPL1", "url": "https://www.uniprot.org/uniprotkb/F1MPL1" } ], "pmid": "" }, { "name": "mitochondrion localization", "id": "GO:0051646", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051646", "evidence": [ { "database": "UniProtKB", "id": "F1MPL1", "url": "https://www.uniprot.org/uniprotkb/F1MPL1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 466, "end_pos": 468, "annotation": "n_glycosylation_sequon" }, { "start_pos": 574, "end_pos": 576, "annotation": "n_glycosylation_sequon" }, { "start_pos": 664, "end_pos": 666, "annotation": "n_glycosylation_sequon" }, { "start_pos": 710, "end_pos": 712, "annotation": "n_glycosylation_sequon" }, { "start_pos": 728, "end_pos": 730, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MPL1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 742, 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IDGPFKY", "url": "https://omabrowser.org/oma/group/IDGPFKY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MK72", "url": "https://www.orthodb.org/?gene=F1MK72", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12901", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12901", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12901:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12901:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03364", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03364", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-611105", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9864848", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TK88", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TK88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MK72", "url": "https://www.uniprot.org/uniprotkb/F1MK72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MK72-1", "url": "https://www.uniprot.org/uniprotkb/F1MK72-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIMAARIGQRALKKVVSGCCPKSAAAARAPAPAQVPARNVSYLASCGILMSRTLPLHTSVFPKKIHARTFFRIAAPLINKRKEYSERRIIGYSMQEMYDVVSGMEDYKHFVPWCKKSDIISRRSGYCKTRLEIGFPPVLERYTSVVTLVKPHLVKASCTDGKLFNHLETVWRFSPGLPGYPRTCTLDFSISFEFRSLLHSQLAMLFFDEVVKQMVTAFERRACKLYGPETNIPRELMLHEVHHT", "length": 244, "header": "tr|F1MK72-1|F1MK72_BOVIN Isoform 1 of Coenzyme Q-binding protein COQ10 homolog B, mitochondrial OS=Bos taurus OX=9913 GN=COQ10B PE=3 SV=1 CANONICAL=F1MK72-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TK88-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TK88/entry", "sequence": { "sequence": "MIMAARIGQRALKKVVSGCCPKSAAAARAPAPAQVPARNVSYSMQEMYDVVSGMEDYKHFVPWCKKSDIISRRSGYCKTRLEIGFPPVLERYTSVVTLVKPHLVKASCTDGKLFNHLETVWRFSPGLPGYPRTCTLDFSISFEFRSLLHSQLAMLFFDEVVKQMVTAFERRACKLYGPETNIPRELMLHEVHHT", "length": 194, "header": "tr|A0AAA9TK88-1|F1MK72_BOVIN Computationally mapped isoform of Coenzyme Q-binding protein COQ10 homolog B, mitochondrial OS=Bos taurus OX=9913 GN=COQ10B PE=3 SV=1 CANONICAL=F1MK72-1" }, "locus": { "chromosome": "2", "start_pos": 86023429, "end_pos": 86007400, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000104849.1", "url": "https://www.ensembl.org/id/ENSBTAT00000104849.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097612.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097612.1" } ] } }, { "isoform_ac": "F1MK72-1", "url": "https://www.uniprot.org/uniprotkb/F1MK72/entry", "sequence": { "sequence": "MIMAARIGQRALKKVVSGCCPKSAAAARAPAPAQVPARNVSYLASCGILMSRTLPLHTSVFPKKIHARTFFRIAAPLINKRKEYSERRIIGYSMQEMYDVVSGMEDYKHFVPWCKKSDIISRRSGYCKTRLEIGFPPVLERYTSVVTLVKPHLVKASCTDGKLFNHLETVWRFSPGLPGYPRTCTLDFSISFEFRSLLHSQLAMLFFDEVVKQMVTAFERRACKLYGPETNIPRELMLHEVHHT", "length": 244, "header": "tr|F1MK72-1|F1MK72_BOVIN Isoform 1 of Coenzyme Q-binding protein COQ10 homolog B, mitochondrial OS=Bos taurus OX=9913 GN=COQ10B PE=3 SV=1 CANONICAL=F1MK72-1" }, "locus": { "chromosome": "2", "start_pos": 86023429, "end_pos": 86007400, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006115.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006115.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006115.4", "url": "https://www.ensembl.org/id/ENSBTAP00000006115.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-611105", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-611105", "resource": "Reactome", "description": "Respiratory electron transport" }, { "id": "R-BTA-9864848", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9864848", "resource": "Reactome", "description": "Complex IV assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8D1P741-1", "protein_name": "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial", "gene_name": "COQ10B", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MFVAARTGQRTLRKVVSGCRPKSATATGVPAPAQGPPRNIRYLASCGILMNRTLPLHSSFLPKEIYARTFFRIAAPLINKRKEYSERRIIGYSMQEMYDVVSGMEDYKHFVPWCKKSDVISRRSGYCKTRLEIGFPPVLERYTSVVTLVKPHLVKASCTDGKLFNHLETVWRFSPGLPGYPRTCTLDFSISFEFRSLLHSQLATLFFDEVVKQMVAAFERRACKLYGPETSIPRELMLHEVHHT", "length": 244 }, "evidence": [ { "id": "F1MK72", "url": "https://omabrowser.org/oma/group/F1MK72/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0YSH9-1", "protein_name": "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial", "gene_name": "COQ10B", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MARSGRALGRALTGRLAAAPQPRAAAVRHLASCGILMTRISPLQVPVLSHTFSRSFFNIAAPLVNKRKEYSERRIIGYSMQEMYEVVAVVENYKLFVPWCKKSDVLSKRSGYCKAQLEIGFPPVVERYTSVVTLVRPHLVKASCTDGKLFNHLETVWRFSPGIPAYPRTCTLDFAISFEFRSLLHSQLATLFFDEVVKQMVAAFERRASKLHGPETSIPRELMFHEVHQT", "length": 230 }, "evidence": [ { "id": "F1MK72", "url": "https://omabrowser.org/oma/group/F1MK72/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q08058-1", "protein_name": "Coenzyme Q-binding protein COQ10, mitochondrial", "gene_name": "COQ10", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVLIIRPSQTLILFRKAMLKPIGRYPLKRNFFGLSGTNHTIREQRYVLRKAINAPPSTVYAAVSEVAQYKEFIPYCVDSFVDKRNPVDNKPLIAGLRVGFKQYDEEFICNVTCKDTDHTYTVVAETISHNLFHLLISKWTIMPHPNRPNAAMVELLLRFKFKSRIYNSVSLIFAKTVTELVMNAFAKRAYHLVRLAMLKPSSKEGSP", "length": 207 }, "evidence": [ { "id": "F1MK72", "url": "https://omabrowser.org/oma/group/F1MK72/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q3THF9-1", "protein_name": "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial", "gene_name": "Coq10b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAARTSQRALARVASGCHPKSTTVTEATARGSARDVRHLAACGVLINRTLPPCAAVLPKEICARTFFRISAPLVNKRKEYSERRILGYSMQEMYDVVSGMEDYQHFVPWCKKSDIISRRSGYCKTRLEVGFPPVLERYTSIVTLVKPHLVKASCTDGKLFNHLETIWRFSPGLPGYPRTCTLDFSISFEFRSLLHSQLATLFFDEVVKQMVAAFERRACKLYGPETNIPRELMLHEIHHT", "length": 240 }, "evidence": [ { "id": "F1MK72", "url": "https://omabrowser.org/oma/group/F1MK72/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q556V1-1", "protein_name": "Coenzyme Q-binding protein COQ10, mitochondrial", "gene_name": "coq10-2", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIKYSNLVIPKTKSILKSGCNNNIGYGDRYFFNKLFGSNDASDTHNQPTTKIVTKEMTKELKYPVNQVYSVIIKVEDYKEFLPFCLNSTILKREKDKNHFEAELEVGQGTIKESYVSKVVYKENKFIESTATDTPLFHKLINTWSFKQGQTPNTTIAHCKLIYQFKSPFYATLMENFFASSLDVMINSFDKRCDELYGSSNSFKK", "length": 205 }, "evidence": [ { "id": "F1MK72", "url": "https://omabrowser.org/oma/group/F1MK72/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q5I0I9-1", "protein_name": "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial", "gene_name": "Coq10b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAARTSQRTLARVASGCRPKSTTVTEARVRGSARNVRYLAPCGILMNRTLAPWASVLPKEICARTFFRITTPLVNKRKEYSERRIIGYSMQEMYDVVSGMEDYKHFVPWCKKSDILSRRSGYCKTRLEIGFPPVLERYTSIVTLVKPHLVKASCTDGKLFNHLETVWRFSPGLPGYPRTCTLDFSISFEFRSLLHSQLATLFFDEVVKQMVAAFERRACKLYGPETNIPRELMLHEIHHT", "length": 240 }, "evidence": [ { "id": "F1MK72", "url": "https://omabrowser.org/oma/group/F1MK72/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9H8M1-1", "protein_name": "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial", "gene_name": "COQ10B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAARTGHTALRRVVSGCRPKSATAAGAQAPVRNGRYLASCGILMSRTLPLHTSILPKEICARTFFKITAPLINKRKEYSERRILGYSMQEMYDVVSGVEDYKHFVPWCKKSDVISKRSGYCKTRLEIGFPPVLERYTSVVTLVKPHLVKASCTDGRLFNHLETIWRFSPGLPGYPRTCTLDFSISFEFRSLLHSQLATLFFDEVVKQMVAAFERRACKLYGPETNIPRELMLHEVHHT", "length": 238 }, "evidence": [ { "id": "F1MK72", "url": "https://omabrowser.org/oma/group/F1MK72/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "F1MK72", "url": "https://www.uniprot.org/uniprotkb/F1MK72" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1MK72", "url": "https://www.uniprot.org/uniprotkb/F1MK72" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cellular respiration", "id": "GO:0045333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045333", "evidence": [ { "database": "UniProtKB", "id": "F1MK72", "url": "https://www.uniprot.org/uniprotkb/F1MK72" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "ubiquinone binding", "id": "GO:0048039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048039", "evidence": [ { "database": "UniProtKB", "id": "F1MK72", "url": "https://www.uniprot.org/uniprotkb/F1MK72" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 39, "end_pos": 41, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MK72-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 244, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MK72-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MK72" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MK72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MK72" }, { "id": "PF03364", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03364" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Coenzyme Q-binding protein COQ10 START", "eco_id": "ECO_0000259", "start_pos": 90, "end_pos": 219, "start_aa": "Ile", "end_aa": "Glu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 39, "end_pos": 41 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MM71-1", "uniprot_ac": "F1MM71", "uniprot_id": "F1MM71_BOVIN", "mass": { "chemical_mass": 55291.0, "monoisotopic_mass": 55291.0 }, "refseq": {}, "gene_names": [ { "name": "LOC100139670", "type": "recommended", "evidence": [ { "id": "F1MM71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ] } ], "protein_names": [ { "name": "Interferon induced protein with tetratricopeptide repeats 1", "type": "synonym", "evidence": [ { "id": "F1MM71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM71/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC100139670", "url": "https://www.uniprot.org/uniprotkb/F1MM71", "locus": {} } ], "crossref": [ { "id": "F1MM71", "url": "https://alphafold.ebi.ac.uk/entry/F1MM71", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007881", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007881", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "100139670", "url": "https://www.ncbi.nlm.nih.gov/gene/100139670", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013105", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013105", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DHQVKDS", "url": "https://omabrowser.org/oma/group/DHQVKDS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MM71", "url": "https://www.orthodb.org/?gene=F1MM71", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10271", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10271", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10271:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10271:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07719", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07719", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13176", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13176", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13181", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13181", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF13424", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13424", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1169408", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1169408", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TKE4", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TKE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU22", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TU22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU22-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MM71-1", "url": "https://www.uniprot.org/uniprotkb/F1MM71-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDQSSYKADEDQLKDKLLLLRCHFTWDMIIAETEIPDLENRVLEEIMFLDIKYNVGIYNLLAYVKHLRGQNEEALKSLQKAEDLSQQEHANQSEVRSLVTWGNYAWLHYHMGQQAEAQIYLDKVKNTCRKLGNSSSYRMACPQMDCEEGWALLKCGGKNYERAKVCFEKALEVDPENPEFSTGYAIVVYRLEGFNKAQISAEFCLNTLKQAVKLNPNDAYIKALLGLKLQDVEQEAEGEKYIKEALTNASSKAYVFRYAAKFYRRKGVLDEALRLSKLALEETPSSAFLHHQTGLCYKSQISQIKFATNCQPKGQDKENINRIIPLAIHHLERAVQLKPTFELAYTSLAEMYAEAGDHRKADDTFQKVLCMKALDKEVLQHIHLHYGRFLEFHKKSEVDAISHYLKAIKIQSPSTDRDKSINSLTKLASKKLRRNPSDIESLSILGFIHKVKGEMNEALEYYERALRLAPGLENSAVIPRH", "length": 482, "header": "tr|F1MM71-1|F1MM71_BOVIN Isoform 1 of Interferon induced protein with tetratricopeptide repeats 1 OS=Bos taurus OX=9913 GN=LOC100139670 PE=3 SV=4 CANONICAL=F1MM71-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TKE4-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TKE4/entry", "sequence": { "sequence": "MSYKADEDQLKDKLLLLRCHFTWDMIIAETEIPDLENRVLEEIMFLDIKYNVGIYNLLAYVKHLRGQNEEALKSLQKAEDLSQQEHANQSEVRSLVTWGNYAWLHYHMGQQAEAQIYLDKVKNTCRKLGNSSSYRMACPQMDCEEGWALLKCGGKNYERAKVCFEKALEVDPENPEFSTGYAIVVYRLEGFNKAQISAEFCLNTLKQAVKLNPNDAYIKALLGLKLQDVEQEAEGEKYIKEALTNASSKAYVFRYAAKFYRRKGVLDEALRLSKLALEETPSSAFLHHQTGLCYKSQISQIKFATNCQPKGQDKENINRIIPLAIHHLERAVQLKPTFELAYTSLAEMYAEAGDHRKADDTFQKVLCMKALDKEVLQHIHLHYGRFLEFHKKSEVDAISHYLKAIKIQSPSTDRDKSINSLTKLASKKLRRNPSDIESLSILGFIHKVKGEMNEALEYYERALRLAPGLENSAVIPRH", "length": 478, "header": "tr|A0AAA9TKE4-1|F1MM71_BOVIN Computationally mapped isoform of Interferon induced protein with tetratricopeptide repeats 1 OS=Bos taurus OX=9913 GN=LOC100139670 PE=3 SV=1 CANONICAL=F1MM71-1" }, "locus": { "chromosome": "26", "start_pos": 11074392, "end_pos": 11069500, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000118764.2", "url": "https://www.ensembl.org/id/ENSBTAT00000118764.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000097408.1", "url": "https://www.ensembl.org/id/ENSBTAP00000097408.1" } ] } }, { "isoform_ac": "A0AAA9TU22-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU22/entry", "sequence": { "sequence": "MIIAETEIPDLENRVLEEIMFLDIKYNVGIYNLLAYVKHLRGQNEEALKSLQKAEDLSQQEHANQSEVRSLVTWGNYAWLHYHMGQQAEAQIYLDKVKNTCRKLGNSSSYRMACPQMDCEEGWALLKCGGKNYERAKVCFEKALEVDPENPEFSTGYAIVVYRLEGFNKAQISAEFCLNTLKQAVKLNPNDAYIKALLGLKLQDVEQEAEGEKYIKEALTNASSKAYVFRYAAKFYRRKGVLDEALRLSKLALEETPSSAFLHHQTGLCYKSQISQIKFATNCQPKGQDKENINRIIPLAIHHLERAVQLKPTFELAYTSLAEMYAEAGDHRKADDTFQKVLCMKALDKEVLQHIHLHYGRFLEFHKKSEVDAISHYLKAIKIQSPSTDRDKSINSLTKLASKKLRRNPSDIESLSILGFIHKVKGEMNEALEYYERALRLAPGLENSAVIPRH", "length": 454, "header": "tr|A0AAA9TU22-1|F1MM71_BOVIN Computationally mapped isoform of Interferon induced protein with tetratricopeptide repeats 1 OS=Bos taurus OX=9913 GN=LOC100139670 PE=3 SV=1 CANONICAL=F1MM71-1" }, "locus": { "chromosome": "26", "start_pos": 11074392, "end_pos": 11073031, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108131.2", "url": "https://www.ensembl.org/id/ENSBTAT00000108131.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100889.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100889.1" } ] } }, { "isoform_ac": "F1MM71-1", "url": "https://www.uniprot.org/uniprotkb/F1MM71/entry", "sequence": { "sequence": "MEDQSSYKADEDQLKDKLLLLRCHFTWDMIIAETEIPDLENRVLEEIMFLDIKYNVGIYNLLAYVKHLRGQNEEALKSLQKAEDLSQQEHANQSEVRSLVTWGNYAWLHYHMGQQAEAQIYLDKVKNTCRKLGNSSSYRMACPQMDCEEGWALLKCGGKNYERAKVCFEKALEVDPENPEFSTGYAIVVYRLEGFNKAQISAEFCLNTLKQAVKLNPNDAYIKALLGLKLQDVEQEAEGEKYIKEALTNASSKAYVFRYAAKFYRRKGVLDEALRLSKLALEETPSSAFLHHQTGLCYKSQISQIKFATNCQPKGQDKENINRIIPLAIHHLERAVQLKPTFELAYTSLAEMYAEAGDHRKADDTFQKVLCMKALDKEVLQHIHLHYGRFLEFHKKSEVDAISHYLKAIKIQSPSTDRDKSINSLTKLASKKLRRNPSDIESLSILGFIHKVKGEMNEALEYYERALRLAPGLENSAVIPRH", "length": 482, "header": "tr|F1MM71-1|F1MM71_BOVIN Isoform 1 of Interferon induced protein with tetratricopeptide repeats 1 OS=Bos taurus OX=9913 GN=LOC100139670 PE=3 SV=4 CANONICAL=F1MM71-1" }, "locus": { "chromosome": "26", "start_pos": 11074392, "end_pos": 11072842, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010366.8", "url": "https://www.ensembl.org/id/ENSBTAT00000010366.8" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010366.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010366.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1169408", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1169408", "resource": "Reactome", "description": "ISG15 antiviral mechanism" } ], "orthologs": [ { "uniprot_canonical_ac": "D3Z6F0-1", "protein_name": "Interferon induced protein with tetratricpeptide repeats 1B like 1", "gene_name": "Ifit1bl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEQLLSPSNMSAKSHSCLIYDSLVELRCHFTWKLVIEKVDMPDLEVRISETEFFDASYSIGMHNLLAYVRHLKGQQEEALQSLKEAEALIQSEQLSKRRLVTWGNCAWLHYHRGSLAEAQVYLDKVEKVCKEFSSPFQYRLECAEMDCEEGWALLKCGIQNYKGAMACFAKALKVEPENPEYNAGYAVVAYRLDHIDGTSLQHLQKAVSVKPEDPYLKVLLALKLQDLHKLEEAEKHIEETLPRISSQPYVFGYVAKFYRRKGLVKEALEFLGRALQKQPCSTFLHFQIGLCHKKRLIQIKKASNMQPRGEDRKRADQSIHLAICHFKRTLELKPTYVMAYVTLAEMYIEKNQLKEAEDNFQKLLNMSNLEDHIQQEIHFRYGNFQQYYKKSEEAAITHYLKGLKIEVTSHYRDKPLKALEKLAKRRKEDHVLENLGLLGFVYKLKGNTSEAMSCYERALRLTGAVNPEF", "length": 470 }, "evidence": [ { "id": "F1MM71", "url": "https://omabrowser.org/oma/group/F1MM71/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P09914-1", "protein_name": "Antiviral innate immune response effector IFIT1", "gene_name": "IFIT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSTNGDDHQVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLDTKYSVGIHNLLAYVKHLKGQNEEALKSLKEAENLMQEEHDNQANVRSLVTWGNFAWMYYHMGRLAEAQTYLDKVENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLRQAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALANMSSQTYVFRYAAKFYRRKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQMIQIKEATKGQPRGQNREKLDKMIRSAIFHFESAVEKKPTFEVAHLDLARMYIEAGNHRKAEENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAIKIEQASLTRDKSINSLKKLVLRKLRRKALDLESLSLLGFVYKLEGNMNEALEYYERALRLAADFENSVRQGP", "length": 478 }, "evidence": [ { "id": "F1MM71", "url": "https://omabrowser.org/oma/group/F1MM71/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" }, { "name": "response to other organism", "id": "GO:0051707", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051707", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" }, { "name": "cellular response to exogenous dsRNA", "id": "GO:0071360", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071360", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" }, { "name": "cellular response to type I interferon", "id": "GO:0071357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071357", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" }, { "name": "intracellular transport of viral protein in host cell", "id": "GO:0019060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019060", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" }, { "name": "negative regulation of viral genome replication", "id": "GO:0045071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045071", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" }, { "name": "cellular response to cytokine stimulus", "id": "GO:0071345", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071345", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" }, { "name": "positive regulation of viral genome replication", "id": "GO:0045070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045070", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" }, { "name": "antiviral innate immune response", "id": "GO:0140374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140374", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" }, { "name": "negative regulation of viral translation", "id": "GO:1904972", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904972", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" }, { "name": "enzyme inhibitor activity", "id": "GO:0004857", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004857", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" }, { "name": "RNA sequestering activity", "id": "GO:0140610", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140610", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" }, { "name": "host cell", "id": "GO:0043657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043657", "evidence": [ { "database": "UniProtKB", "id": "F1MM71", "url": "https://www.uniprot.org/uniprotkb/F1MM71" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 249, "end_pos": 251, "annotation": "n_glycosylation_sequon" }, { "start_pos": 92, "end_pos": 94, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MM71-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 482, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MM71-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MM71" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 134, "end_pos": 136 }, { "start_pos": 249, "end_pos": 251 }, { "start_pos": 92, "end_pos": 94 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MLV5-1", "uniprot_ac": "F1MLV5", "uniprot_id": "F1MLV5_BOVIN", "mass": { "chemical_mass": 56773.0, "monoisotopic_mass": 56773.0 }, "refseq": {}, "gene_names": [ { "name": "CYP2C23", "type": "recommended", "evidence": [ { "id": "F1MLV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLV5" } ] } ], "protein_names": [ { "name": "Cytochrome P450 family 2 subfamily C member 23", "type": "synonym", "evidence": [ { "id": "F1MLV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLV5/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MLV5", "url": "https://www.uniprot.org/uniprotkb/F1MLV5" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "CYP2C23", "url": "https://www.uniprot.org/uniprotkb/F1MLV5", "locus": { "chromosome": "26", "start_pos": 21016647, "end_pos": 21052310, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000023939", "url": "https://www.ensembl.org/id/ENSBTAG00000023939" } ] } } ], "crossref": [ { "id": "F1MLV5", "url": "https://alphafold.ebi.ac.uk/entry/F1MLV5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000023939", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000023939", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20665", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20665", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HMAYNGR", "url": "https://omabrowser.org/oma/group/HMAYNGR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300:SF346", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300:SF346", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00067", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TLE5", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLE5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TLE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLE5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLV5", "url": "https://www.uniprot.org/uniprotkb/F1MLV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLV5-1", "url": "https://www.uniprot.org/uniprotkb/F1MLV5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERLEITTLALVICVTCLVFLFVWKKSHKGLGKLPPGPTPLPIIGNLMQLNLKDIPASLSKLAKQYGPVYTLHLGSQTTVVLHGYEVVKEALIDQGDEFLGRAHFPIIDDTQRGYGLIFSNGDTWKQMRRFSLMTLRNFGMGKRSLEERIQEEAQFLVEEFRKSEAQPFNPAVTLSCATCNIICSILFNERFHYQDKTLHSLLDLLNENFNRISSLWNQIYNLWPKLIKPLPGEHRAFSKRLKDVHYFVLEKVKEHQKSLNHNNPRDYIDCFLSRMEQEKQNPESQFHLENLATCGSNLFSAGVETTTATLSYGFLLLMKYPEVQAKVHEEIDRVIGRTRSPCMKDKMKLPYTEAVLHEIQRYVTLVPSNLPHAVVQDTKFRQYVIPKGTTVLPLLSSILYDCKEFPNPEKFDPGHFLDKNGSFRKTKYFVAFSIGKRACVGEGLAQMELFLFFTTILQNFVLKPLGETKDIETKPIVIGLINMPPPFKLCLIPR", "length": 495, "header": "tr|F1MLV5-1|F1MLV5_BOVIN Isoform 1 of Cytochrome P450 family 2 subfamily C member 23 OS=Bos taurus OX=9913 GN=CYP2C23 PE=1 SV=1 CANONICAL=F1MLV5-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TLE5-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLE5/entry", "sequence": { "sequence": "MYLLSLCMYYSIHLVYFFSLIALTLLTPIESSRLQRELLELPAQLAKQYGPVYTLHLGSQTTVVLHGYEVVKEALIDQGDEFLGRAHFPIIDDTQRGYGLIFSNGDTWKQMRRFSLMTLRNFGMGKRSLEERIQEEAQFLVEEFRKSEAQPFNPAVTLSCATCNIICSILFNERFHYQDKTLHSLLDLLNENFNRISSLWNQIYNLWPKLIKPLPGEHRAFSKRLKDVHYFVLEKVKEHQKSLNHNNPRDYIDCFLSRMEQEKQNPESQFHLENLATCGSNLFSAGVETTTATLSYGFLLLMKYPEVQAKVHEEIDRVIGRTRSPCMKDKMKLPYTEAVLHEIQRYVTLVPSNLPHAVVQDTKFRQYVIPKGTTVLPLLSSILYDCKEFPNPEKFDPGHFLDKNGSFRKTKYFVAFSIGKRACVGEGLAQMELFLFFTTILQNFVLKPLGETKDIETKPIVIGLINMPPPFKLCLIPR", "length": 478, "header": "tr|A0AAA9TLE5-1|F1MLV5_BOVIN Computationally mapped isoform of Cytochrome P450 family 2 subfamily C member 23 OS=Bos taurus OX=9913 GN=CYP2C23 PE=1 SV=1 CANONICAL=F1MLV5-1" }, "locus": { "chromosome": "26", "start_pos": 21052111, "end_pos": 21017162, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000133782.1", "url": "https://www.ensembl.org/id/ENSBTAT00000133782.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099254.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099254.1" } ] } }, { "isoform_ac": "F1MLV5-1", "url": "https://www.uniprot.org/uniprotkb/F1MLV5/entry", "sequence": { "sequence": "MERLEITTLALVICVTCLVFLFVWKKSHKGLGKLPPGPTPLPIIGNLMQLNLKDIPASLSKLAKQYGPVYTLHLGSQTTVVLHGYEVVKEALIDQGDEFLGRAHFPIIDDTQRGYGLIFSNGDTWKQMRRFSLMTLRNFGMGKRSLEERIQEEAQFLVEEFRKSEAQPFNPAVTLSCATCNIICSILFNERFHYQDKTLHSLLDLLNENFNRISSLWNQIYNLWPKLIKPLPGEHRAFSKRLKDVHYFVLEKVKEHQKSLNHNNPRDYIDCFLSRMEQEKQNPESQFHLENLATCGSNLFSAGVETTTATLSYGFLLLMKYPEVQAKVHEEIDRVIGRTRSPCMKDKMKLPYTEAVLHEIQRYVTLVPSNLPHAVVQDTKFRQYVIPKGTTVLPLLSSILYDCKEFPNPEKFDPGHFLDKNGSFRKTKYFVAFSIGKRACVGEGLAQMELFLFFTTILQNFVLKPLGETKDIETKPIVIGLINMPPPFKLCLIPR", "length": 495, "header": "tr|F1MLV5-1|F1MLV5_BOVIN Isoform 1 of Cytochrome P450 family 2 subfamily C member 23 OS=Bos taurus OX=9913 GN=CYP2C23 PE=1 SV=1 CANONICAL=F1MLV5-1" }, "locus": { "chromosome": "26", "start_pos": 21044516, "end_pos": 21017162, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000032930.5", "url": "https://www.ensembl.org/id/ENSBTAT00000032930.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000032857.4", "url": "https://www.ensembl.org/id/ENSBTAP00000032857.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 39, "start_aa": "Thr", "end_pos": 39, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr39", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2MKD1-1", "protein_name": "Cytochrome P450 2C23", "gene_name": "LOC100751762", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MELLGVTTLVLVVSVICLSFLSVWTKTRPGGRLPPGPTPLPVIGNILQLNFKDVPASLSKLAKDYGPIYTLYFGSWPTVVLHGYDVVKEALLNQGDEFLGRGPFPIIEDSLKGSGLVFTNGETWKVLRRFSLMTLKNFGMGKRSLEERVQEEAQCLVEELQKMEAGPFDPTFILACAPCNVICSILFNERFPYRSKTILNLMDLLNKNFHQVNSVWCQMYNLWPTFMKYVPGKHKEVPQRINDINNFILEKIKEHQESLDPANPRDYIDCFLSKIEEEKHNPKSEFDLKNLIASGASLFTAGTETTSITLRFGILLLLKYPEVQAKIHEEIDHVIGRHQPPSMKDKMKLPYTNAVLHEIQRYTTLLPSSLPHAVVKDTKFRDYIIPKGTVVLPLLSSILLDHKEFPNPETFDPGHFLDKNGCFKKTDYFVPFSLGKRSCMGESLAIMELFLFLTTILQKFSLKSPVEPRDLDIKPAATGLINIPPPYKLCLIPR", "length": 494 }, "evidence": [ { "id": "F1MLV5", "url": "https://omabrowser.org/oma/group/F1MLV5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "E9Q5K4-1", "protein_name": "Cytochrome P450 2C44", "gene_name": "Cyp2c23", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELLGLPTLALLVLVMSLSLLSVWTKMRTGGRLPPGPTPLPIIGNILQLDLKDIPASLSKLAKEYGPVYTLYFGSWPTVVLHGYDVVKEALLNQGDEFLGRGPLPIIEDSQKGHGIVFSEGERWKLLRRFSLMTLKNFGMGKRSLEERVQEEARCLVEELHKTEAQPFDPTFILACAPCNVICSILFNERFPYNDKTFLNLMDLLNKNFYQLNSIWIQMYNLWPTIMKYIPGKHREFSKRLGGVKNFILEKVKEHQESLDPANPRDYIDCFLSKIEEEKHNLKSDFNLENLAICGSNLFTAGTETTSTTLRFGLLLLVKHPEVQAKVHEELDRVIGRHQPPSMKDKMKLPYTDAVLHEIQRYITLLPSSLPHAVVQDTKFRHYVIPKGTAVFPFLSSILLDQKEFPNPEKFDPGHFLDKNGCFKKTDYFVPFSLGKRSCVGEGLARMELFLFFTTILQKFSLKALVEPKDLDIKPVTTGLFNLPPPYKLRLVPR", "length": 494 }, "evidence": [ { "id": "F1MLV5", "url": "https://omabrowser.org/oma/group/F1MLV5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P24470-1", "protein_name": "Cytochrome P450 2C23", "gene_name": "Cyp2c23", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELLGFTTLALVVSVTCLSLLSVWTKLRTRGRLPPGPTPLPIIGNLLQLNLKDIPASLSKLAKEYGPVYTLYFGTSPTVVLHGYDVVKEALLQQGDEFLGRGPLPIIEDTHKGYGLIFSNGERWKVMRRFSLMTLRNFGMGKRSLEERVQEEARCLVEELQKTKAQPFDPTFILACAPCNVICSILFNDRFQYNDKTFLNLMDLLNKNFQQVNSVWCQMYNLWPTIIKYLPGKHIEFAKRIDDVKNFILEKVKEHQKSLDPANPRDYIDCFLSKIEEEKDNLKSEFHLENLAVCGSNLFTAGTETTSTTLRFGLLLLMKYPEVQAKVHEELDRVIGRHQPPSMKDKMKLPYTDAVLHEIQRYITLLPSSLPHAVVQDTKFRDYVIPKGTTVLPMLSSVMLDQKEFANPEKFDPGHFLDKNGCFKKTDYFVPFSLGKRACVGESLARMELFLFFTTLLQKFSLKTLVEPKDLDIKPITTGIINLPPPYKLCLVPR", "length": 494 }, "evidence": [ { "id": "F1MLV5", "url": "https://omabrowser.org/oma/group/F1MLV5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q55BU9-1", "protein_name": "Probable cytochrome P450 513A3", "gene_name": "cyp513A3", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTSLTLYLIIFSIILYLFVNRNKRKNLKIPGPNGIPIFGNLLSLSGEMHLTLQEWYKTYGSVFSIRMGNIDTVVLTEYPTIRKAFVDNSLAFASRYQLKSRVVLTGAKDLAIQNGEIHSLLKKVVLSEMTTTKIKRMEIHIIKETEKILKILDKHAERGEPFIINNYLNMFSMNVILRFLLGIDYPYENVDETVGYVKSIKSFFAVAGLPILSDFIPIPLKKSGVFFDSYKELEIETDKLIEKFKKSRNEKIENGTYNEEEDESILSKLLKEYEHGNITWECVSHTCIDIISAGTDTSANTLVMALIELINNQEIQSKAFSSIRSSCLNDSNDDDDDDEIVITHSKYRSLLPYISMIIKETFRKHPIALLGLPHVTTEDVEIDGYKIEAGTYIIQNIFSSHRSDKIFQSPNEFIPERFFESSQNQGLIHFGLGVRDCVGKSLAECEIFTLIATLLNRYQFINPNNSKKLNDIGTFGLAQVCPDTNIILKKRI", "length": 492 }, "evidence": [ { "id": "F1MLV5", "url": "https://omabrowser.org/oma/group/F1MLV5/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "F1MLV5", "url": "https://www.uniprot.org/uniprotkb/F1MLV5" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "F1MLV5", "url": "https://www.uniprot.org/uniprotkb/F1MLV5" } ], "pmid": "" }, { "name": "monooxygenase activity", "id": "GO:0004497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "database": "UniProtKB", "id": "F1MLV5", "url": "https://www.uniprot.org/uniprotkb/F1MLV5" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "id": "GO:0016705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016705", "evidence": [ { "database": "UniProtKB", "id": "F1MLV5", "url": "https://www.uniprot.org/uniprotkb/F1MLV5" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "id": "GO:0016712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712", "evidence": [ { "database": "UniProtKB", "id": "F1MLV5", "url": "https://www.uniprot.org/uniprotkb/F1MLV5" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1MLV5", "url": "https://www.uniprot.org/uniprotkb/F1MLV5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MLV5", "url": "https://www.uniprot.org/uniprotkb/F1MLV5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "xenobiotic catabolic process", "id": "GO:0042178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042178", "evidence": [ { "database": "UniProtKB", "id": "F1MLV5", "url": "https://www.uniprot.org/uniprotkb/F1MLV5" } ], "pmid": "" }, { "name": "epoxygenase P450 pathway", "id": "GO:0019373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019373", "evidence": [ { "database": "UniProtKB", "id": "F1MLV5", "url": "https://www.uniprot.org/uniprotkb/F1MLV5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 421, "end_pos": 423, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MLV5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 495, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MLV5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MLV5" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 39 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 421, "end_pos": 423 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MS86-1", "uniprot_ac": "F1MS86", "uniprot_id": "F1MS86_BOVIN", "mass": { "chemical_mass": 34315.0, "monoisotopic_mass": 34315.0 }, "refseq": {}, "gene_names": [ { "name": "DERL3", "type": "recommended", "evidence": [ { "id": "F1MS86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS86" } ] } ], "protein_names": [ { "name": "Derlin", "type": "recommended", "evidence": [ { "id": "F1MS86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MS86/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.", "evidence": [ { "database": "UniProtKB", "id": "A0AAA9TPL1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TPL1#function" }, { "database": "UniProtKB", "id": "RU363059", "url": "https://www.uniprot.org/uniprotkb/RU363059#function" }, { "database": "UniProtKB", "id": "F1MS86", "url": "https://www.uniprot.org/uniprotkb/F1MS86#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MS86", "url": "https://www.uniprot.org/uniprotkb/F1MS86" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "DERL3", "url": "https://www.uniprot.org/uniprotkb/F1MS86", "locus": { "chromosome": "17", "start_pos": 71260779, "end_pos": 71263442, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000022028", "url": "https://www.ensembl.org/id/ENSBTAG00000022028" } ] } } ], "crossref": [ { "id": "F1MS86", "url": "https://alphafold.ebi.ac.uk/entry/F1MS86", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000022028", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000022028", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR007599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MS86", "url": "https://www.orthodb.org/?gene=F1MS86", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11009", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11009", 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"description": "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1MS86", "url": "https://www.uniprot.org/uniprotkb/F1MS86" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "proteasomal protein catabolic process", "id": "GO:0010498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010498", "evidence": [ { "database": "UniProtKB", "id": "F1MS86", "url": "https://www.uniprot.org/uniprotkb/F1MS86" } ], "pmid": "" }, { "name": "cellular response to stress", "id": "GO:0033554", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033554", "evidence": [ { "database": "UniProtKB", "id": "F1MS86", "url": "https://www.uniprot.org/uniprotkb/F1MS86" } ], "pmid": "" }, { "name": "protein N-linked glycosylation", "id": "GO:0006487", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006487", "evidence": [ { "database": "UniProtKB", "id": "F1MS86", "url": "https://www.uniprot.org/uniprotkb/F1MS86" } ], "pmid": "" }, { "name": "endoplasmic reticulum unfolded protein response", "id": "GO:0030968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968", "evidence": [ { "database": "UniProtKB", "id": "F1MS86", "url": "https://www.uniprot.org/uniprotkb/F1MS86" } ], "pmid": "" }, { "name": "ERAD pathway", "id": "GO:0036503", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503", "evidence": [ { "database": "UniProtKB", "id": "F1MS86", "url": "https://www.uniprot.org/uniprotkb/F1MS86" } ], "pmid": "" }, { "name": "negative regulation of retrograde protein transport, ER to cytosol", "id": "GO:1904153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904153", "evidence": [ { "database": "UniProtKB", "id": "F1MS86", "url": "https://www.uniprot.org/uniprotkb/F1MS86" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "signal recognition particle binding", "id": "GO:0005047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005047", "evidence": [ { "database": "UniProtKB", "id": "F1MS86", "url": "https://www.uniprot.org/uniprotkb/F1MS86" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MS86-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 313, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MS86-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MS86" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 291, 293 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, 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"field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MQF9-1", "uniprot_ac": "F1MQF9", "uniprot_id": "F1MQF9_BOVIN", "mass": { "chemical_mass": 132601.0, 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Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. 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], "crossref": [ { "id": "F1MQF9", "url": "https://alphafold.ebi.ac.uk/entry/F1MQF9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019332", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019332", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00038", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00038", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000595", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000595", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006153", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006153", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014710", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014710", "database": "InterPro", 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"PF00520", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00520", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00999", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00999", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TR98", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TR98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQF9", "url": "https://www.uniprot.org/uniprotkb/F1MQF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQF9-1", "url": "https://www.uniprot.org/uniprotkb/F1MQF9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"length": 1145, "header": "tr|F1MQF9-1|F1MQF9_BOVIN Isoform 1 of Solute carrier family 9 member C1 OS=Bos taurus OX=9913 GN=SLC9C1 PE=3 SV=4 CANONICAL=F1MQF9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TR98-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TR98/entry", "sequence": { "sequence": "MDGQISNLTFHRKEFTDEWLEVFRHSFLETSQELPKIILILSLICMIGGELTEMSGTFTLVIMGLFLNSTNFKPGVEALILEFWNCLSFVAFLMVFTFTGLLIPAHTYLYISFSDIYYSLNIYLTLIMFRLLVFLLLSPLLSRLGHGFSWRWAFIMVWSEMKGTPNINLALLLAYFENSYGSEREKSQILFHGVSVSLISLIVNRFILPMAVTKLGLRDVTSTKYKSLYYTFQHFQELTKSVASALKFDRDLANADWNIVEKTIILQNPYALGQGETKEHQKVKCQHCNKEIDDNLNIEAMELANRRLLSAQIASYQRQYRSETLSQSAIQVLVGAAGSFGEKMVEYMNAETIKNYSESKKILVFTRKVLLNWVYNTKKEKGIPSRHCFLRACHKIVFTDEFEYIGYLVILMNMFPIIISCISVLNDIYETELAYANYSFLAFYIMEALLKIAAMRKEYFFHAWNLFELTITLVGIIDVMLIETNSINYYIFDLVQIVIIMKIVRFLRILRILKLVTPRLLQILDKRMSHQLSFRYAILKGYVQGEADIMTIIDKIASSKQVKQMLLRRVTKNTGHAMKELGYLEYDHPEIAVTMKTKEEINVMLSLAREIVKVFRLKGILHKIEGSEINKIIMAKKRDILDFQPTYKPLTVEEALYHIPWLDKDEEHISFIQLQRSKPGLGIDQIIWESEEKDYQITYTDFVISGAVIGELNCLTNAPMKYSATCKTVVETCFIPKNHLYEAFEQFYPHIEYRMWLKLGLSITAKKIREHLSYEDWNYKMQLKLSNIYVKDIPKNTKTDIYDETVIYVILIHGAVEDCQLRKAYKAPFLIPITCHQIQGTEDFTKVTIVQTSIYSKRFRWNTRKYIASHKPADPTTSGM", "length": 880, "header": "tr|A0AAA9TR98-1|F1MQF9_BOVIN Computationally mapped isoform of Solute carrier family 9 member C1 OS=Bos taurus OX=9913 GN=SLC9C1 PE=3 SV=1 CANONICAL=F1MQF9-1" }, "locus": { "chromosome": "1", "start_pos": 57060956, "end_pos": 56963726, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000094310.1", "url": "https://www.ensembl.org/id/ENSBTAT00000094310.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000099836.1", "url": "https://www.ensembl.org/id/ENSBTAP00000099836.1" } ] } }, { "isoform_ac": "F1MQF9-1", "url": "https://www.uniprot.org/uniprotkb/F1MQF9/entry", "sequence": { "sequence": "MDGQISNLTFHRKEFTDEWLEVFRHSFLETSQELPKIILILSLICMIGALLNQHLKDFPIPLPVILFLLGCSFEMLSFTSDKVQEYADAIQWMDSHLFFNLFTPVIIFSVAFDMDVYLLHKLFWQIVFITVPGFLINYTLILWYLASVNKLLLKTTPWLLFSAILVSLDPMLTSSAIKDLGLSRSLVSLINGESLMTSVMSLITFTVIVNIDLSLHKNTIQSLVSFSFGIVSSKLIQLWMSTVFGEDVNHISLSFSFLYLIFYICELTEMSGTFTLVIMGLFLNSTNFKPGVEALILEFWNCLSFVAFLMVFTFTGLLIPAHTYLYISFSDIYYSLNIYLTLIMFRLLVFLLLSPLLSRLGHGFSWRWAFIMVWSEMKGTPNINLALLLAYFENSYGSEREKSQILFHGVSVSLISLIVNRFILPMAVTKLGLRDVTSTKYKSLYYTFQHFQELTKSVASALKFDRDLANADWNIVEKTIILQNPYALGQGETKEHQKVKCQHCNKEIDDNLNIEAMELANRRLLSAQIASYQRQYRSETLSQSAIQVLVGAAGSFGEKMVEYMNAETIKNYSESKKILVFTRKVLLNWVYNTKKEKGIPSRHCFLRACHKIVFTDEFEYIGYLVILMNMFPIIISCISVLNDIYETELAYANYSFLAFYIMEALLKIAAMRKEYFFHAWNLFELTITLVGIIDVMLIETNSINYYIFDLVQIVIIMKIVRFLRILRILKLVTPRLLQILDKRMSHQLSFRYAILKGYVQGEADIMTIIDKIASSKQVKQMLLRRVTKNTGHAMKELGYLEYDHPEIAVTMKTKEEINVMLSLAREIVKVFRLKGILHKIEGSEINKIIMAKKRDILDFQPTYKPLTVEEALYHIPWLDKDEEHISFIQERSRVVTFDCGNDIFEEGDEPKGIYVIISGMVKLQRSKPGLGIDQIIWESEEKDYQITYTDFVISGAVIGELNCLTNAPMKYSATCKTVVETCFIPKNHLYEAFEQFYPHIEYRMWLKLGLSITAKKIREHLSYEDWNYKMQLKLSNIYVKDIPKNTKTDIYDETVIYVILIHGAVEDCQLRKAYKAPFLIPITCHQIQGTEDFTKVTIVQTSIYSKRFRWNTRKYIASHKPADPTTSEKIDEEISSSFQKLKYFI", "length": 1145, "header": "tr|F1MQF9-1|F1MQF9_BOVIN Isoform 1 of Solute carrier family 9 member C1 OS=Bos taurus OX=9913 GN=SLC9C1 PE=3 SV=4 CANONICAL=F1MQF9-1" }, "locus": { "chromosome": "1", "start_pos": 57060956, "end_pos": 56963411, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000061361.4", "url": "https://www.ensembl.org/id/ENSBTAT00000061361.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000053611.4", "url": "https://www.ensembl.org/id/ENSBTAP00000053611.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "sodium:proton antiporter activity", "id": "GO:0015385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015385", "evidence": [ { "database": "UniProtKB", "id": "F1MQF9", "url": "https://www.uniprot.org/uniprotkb/F1MQF9" } ], "pmid": "" }, { "name": "monoatomic ion channel activity", "id": "GO:0005216", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005216", "evidence": [ { "database": "UniProtKB", "id": "F1MQF9", "url": "https://www.uniprot.org/uniprotkb/F1MQF9" } ], "pmid": "" }, { "name": "potassium:proton antiporter activity", "id": "GO:0015386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015386", "evidence": [ { "database": "UniProtKB", "id": "F1MQF9", "url": "https://www.uniprot.org/uniprotkb/F1MQF9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MQF9", "url": "https://www.uniprot.org/uniprotkb/F1MQF9" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MQF9", "url": "https://www.uniprot.org/uniprotkb/F1MQF9" } ], "pmid": "" }, { "name": "motile cilium", "id": "GO:0031514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031514", "evidence": [ { "database": "UniProtKB", "id": "F1MQF9", "url": "https://www.uniprot.org/uniprotkb/F1MQF9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "regulation of intracellular pH", "id": "GO:0051453", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051453", "evidence": [ { "database": "UniProtKB", "id": "F1MQF9", "url": "https://www.uniprot.org/uniprotkb/F1MQF9" } ], "pmid": "" }, { "name": "potassium ion transmembrane transport", "id": "GO:0071805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071805", "evidence": [ { "database": "UniProtKB", "id": "F1MQF9", "url": "https://www.uniprot.org/uniprotkb/F1MQF9" } ], "pmid": "" }, { "name": "sodium ion import across plasma membrane", "id": "GO:0098719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098719", "evidence": [ { "database": "UniProtKB", "id": "F1MQF9", "url": "https://www.uniprot.org/uniprotkb/F1MQF9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" }, { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" }, { "start_pos": 571, "end_pos": 573, "annotation": "n_glycosylation_sequon" }, { "start_pos": 653, "end_pos": 655, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MQF9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1145, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MQF9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MQF9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MQF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQF9" }, { "id": "PS50042", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50042" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cyclic nucleotide-binding", "eco_id": "ECO_0000259", "start_pos": 895, "end_pos": 968, "start_aa": "Val", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 137, "end_pos": 139 }, { "start_pos": 284, "end_pos": 286 }, { "start_pos": 571, "end_pos": 573 }, { "start_pos": 653, "end_pos": 655 }, { "start_pos": 7, "end_pos": 9 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", 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"tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MQ89-1", "uniprot_ac": "F1MQ89", "uniprot_id": "F1MQ89_BOVIN", "mass": { "chemical_mass": 83424.0, "monoisotopic_mass": 83424.0 }, "refseq": { "ac": "NP_001070307", "name": "conserved oligomeric Golgi complex subunit 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070307" }, "gene_names": [ { "name": "COG2", "type": "recommended", "evidence": [ { "id": "F1MQ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ89" } ] }, { "name": "COG2", "type": "synonym", "evidence": [ { "id": "NP_001070307", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070307" } ] } ], "protein_names": [ { "name": "Conserved oligomeric Golgi complex subunit 2", "type": "recommended", "evidence": [ { "id": "F1MQ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ89/entry#names_and_taxonomy" } ] }, { "name": "Component of oligomeric Golgi complex 2", "type": "synonym", "evidence": [ { "id": "F1MQ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ89/entry#names_and_taxonomy" } ] }, { "name": "conserved oligomeric Golgi complex subunit 2", "type": "synonym", "evidence": [ { "id": "NP_001070307", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070307" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MQ89", "url": "https://www.uniprot.org/uniprotkb/F1MQ89" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "COG2", "url": "https://www.uniprot.org/uniprotkb/F1MQ89", "locus": { "chromosome": "28", "start_pos": 45772443, "end_pos": 45814853, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020314", "url": "https://www.ensembl.org/id/ENSBTAG00000020314" } ] } } ], "crossref": [ { "id": "F1MQ89", "url": "https://alphafold.ebi.ac.uk/entry/F1MQ89", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020314", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020314", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "512213", "url": "https://www.ncbi.nlm.nih.gov/gene/512213", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR009316", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009316", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024602", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024602", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024603", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024603", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:512213", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512213", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CWAEGVY", "url": "https://omabrowser.org/oma/group/CWAEGVY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MQ89", "url": "https://www.orthodb.org/?gene=F1MQ89", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12961", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12961", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12961:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12961:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06148", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06148", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12022", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12022", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-6807878", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811438", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "NP_001070307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070307", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0AAA9TRY9", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TRY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQ89", "url": "https://www.uniprot.org/uniprotkb/F1MQ89", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MQ89-1", "url": "https://www.uniprot.org/uniprotkb/F1MQ89-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKSRMNLPKGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEALRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALSQLSVPLGQLREEVLSLRSSVSEGIRAVDERLSKQEDIRKKKICVLRLIQVIRSVEKIEKILNSQHSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGLPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSSVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYVDEVILEQIVDSHLSDLQLMYDKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPEIVRGLEEKLPSLFNPGDPDAFHQKYTISMDFVRTFERQCGSQASVKRLRAHPAYHSFNNKWNLPVYFQIRFREIAGSLEAALTDILEDAPAGSPYRLLASHRTWSSLQRCWSDKMFLPLLAHRLWRLTLQILARYSIFVKELLLRPISNESAKDVKKPLVTGSKDLSITQGNCEDQASGPSETKPIVSVSSTQLVYVVTDLHRLQEQLPELLETIKPKLEVMGFKNFSSISAALEDSQLSLSACVPALSEKITQDLSESCFSHLKSALEVPRLYRRTNKEVPVTASSYVDSALKPLYQLQSRHKDKLKQATIRQWLEATLSESTHKYYETVSDVLNSVRKMEESLKRLKQARRTTPASPAGLSGGGMSDDDKIRRQLALDVAYLGEQIEKMGLRTKDIRSFPALAELVAAAKDQATAEQP", "length": 739, "header": "tr|F1MQ89-1|F1MQ89_BOVIN Isoform 1 of Conserved oligomeric Golgi complex subunit 2 OS=Bos taurus OX=9913 GN=COG2 PE=3 SV=1 CANONICAL=F1MQ89-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TRY9-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TRY9/entry", "sequence": { "sequence": "MEKSRMNLPKGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEALRDDLELYYKLLKTAMVELINKDYADFVNLSTNLSLRSSVSEGIRAVDERLSKQEDIRKKKICVLRLIQVIRSVEKIEKILNSQHSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGLPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSSVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYVDEVILEQIVDSHLSDLQLMYDKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPEIVRGLEEKLPSLFNPGDPDAFHQKYTISMDFVRTFERQCGSQASVKRLRAHPAYHSFNNKWNLPVYFQIRFREIAGSLEAALTDILEDAPAGSPYRLLASHRTWSSLQRCWSDKMFLPLLAHRLWRLTLQILARYSIFVKELLLRPISNESAKDVKKPLVTGSKDLSITQGNCEDQASGPSETKPIVSVSSTQLVYVVTDLHRLQEQLPELLETIKPKLEVMGFKNFSSISAALEDSQLSLSACVPALSEKITQDLSESCFSHLKSALEVPRLYRRTNKEVPVTASSYVDSALKPLYQLQSRHKDKLKQATIRQWLEATLSESTHKYYETVSDVLNSVRKMEESLKRLKQARRTTPASPAGLSGGGMSDDDKIRRQLALDVAYLGEQIEKMGLRTKDIRSFPALAELVAAAKDQATAEQP", "length": 717, "header": "tr|A0AAA9TRY9-1|F1MQ89_BOVIN Computationally mapped isoform of Conserved oligomeric Golgi complex subunit 2 OS=Bos taurus OX=9913 GN=COG2 PE=3 SV=1 CANONICAL=F1MQ89-1" }, "locus": { "chromosome": "28", "start_pos": 45814718, "end_pos": 45772994, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000124127.1", "url": "https://www.ensembl.org/id/ENSBTAT00000124127.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101143.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101143.1" } ] } }, { "isoform_ac": "F1MQ89-1", "url": "https://www.uniprot.org/uniprotkb/F1MQ89/entry", "sequence": { "sequence": "MEKSRMNLPKGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEALRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALSQLSVPLGQLREEVLSLRSSVSEGIRAVDERLSKQEDIRKKKICVLRLIQVIRSVEKIEKILNSQHSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGLPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSSVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYVDEVILEQIVDSHLSDLQLMYDKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPEIVRGLEEKLPSLFNPGDPDAFHQKYTISMDFVRTFERQCGSQASVKRLRAHPAYHSFNNKWNLPVYFQIRFREIAGSLEAALTDILEDAPAGSPYRLLASHRTWSSLQRCWSDKMFLPLLAHRLWRLTLQILARYSIFVKELLLRPISNESAKDVKKPLVTGSKDLSITQGNCEDQASGPSETKPIVSVSSTQLVYVVTDLHRLQEQLPELLETIKPKLEVMGFKNFSSISAALEDSQLSLSACVPALSEKITQDLSESCFSHLKSALEVPRLYRRTNKEVPVTASSYVDSALKPLYQLQSRHKDKLKQATIRQWLEATLSESTHKYYETVSDVLNSVRKMEESLKRLKQARRTTPASPAGLSGGGMSDDDKIRRQLALDVAYLGEQIEKMGLRTKDIRSFPALAELVAAAKDQATAEQP", "length": 739, "header": "tr|F1MQ89-1|F1MQ89_BOVIN Isoform 1 of Conserved oligomeric Golgi complex subunit 2 OS=Bos taurus OX=9913 GN=COG2 PE=3 SV=1 CANONICAL=F1MQ89-1" }, "locus": { "chromosome": "28", "start_pos": 45814718, "end_pos": 45772994, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000027073.5", "url": "https://www.ensembl.org/id/ENSBTAT00000027073.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000027073.4", "url": "https://www.ensembl.org/id/ENSBTAP00000027073.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:512213", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:512213", "resource": "KEGG Pathway" }, { "id": "R-BTA-6807878", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6807878", "resource": "Reactome", "description": "COPI-mediated anterograde transport" }, { "id": "R-BTA-6811438", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811438", "resource": "Reactome", "description": "Intra-Golgi traffic" }, { "id": "R-BTA-6811440", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6811440", "resource": "Reactome", "description": "Retrograde transport at the Trans-Golgi-Network" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8C2QJK9-1", "protein_name": "Conserved oligomeric Golgi complex subunit 2", "gene_name": "Cog2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MERRRMNLPTGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDRALNQLSVPLGQLREEVMSLRSSVSEGILAVDERMSKQEDIRKKKMSVLRLIQVIRSVEKIEKILNSQNSKDASSLEASSPLLTGQVLERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSNVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYVNEVIVEQFVESHPSGLQLMYNKLLEFVPHHCRLLREVTGGAVSSEKGAIVPGYDFLVNSVWPEIVRGLEEKLPSLFNPGDPDAFHEKYTVSMDFVQRFERQCGSQASVKRLRAHPAYHSFSNKWNLPVYFQIRFREVAGSLEASLTDGLEDAPDGSPYCLLASHRTWSSLEKCWSNEMFLPLLAHRLWRLTLQILARFSVFVHEISARPISNESTKETKKPLAGSKDPSEDQGSHPSEVQAASISSTQLVYVVSDLDRLQEWLPELLEIVKPKLEMIGFKNFSSISAAMEDSQSSLSAHVPALSSRIVQDLSESCFSYLKSALEVPRLYRRTNKEVPSAASSYVDSALKPFYQLQRGHGNKVKPAVMQHWLQEALSESTHKYFETVSDVLNSVKKMEESLKRLKQARRAPAANPVSSSSGMSDDDKIRLQLALDVEFLGEQIQKMGLQTSDIKSFPALTELVLAARDQATAEQP", "length": 730 }, "evidence": [ { "id": "F1MQ89", "url": "https://omabrowser.org/oma/group/F1MQ89/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "A0A8V0XVQ4-1", "protein_name": "Conserved oligomeric Golgi complex subunit 2", "gene_name": "COG2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEARKMNLPRGPENLCFDKDEFMKPDFDVDHFVSECRKRVQLEELREDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALNQLSVPLGQLREEVMSLRSCVSEGIQAIDDRLSKQEDIRKKKVCVLRLIHVIQSVEKIEKILHSQGTNELSTLEGNSPLLTGQVLERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSNVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYVDEVIVEQYVQAHPNGLQAMYNKLLEFVPHHCRLLREVTGGAISSEKADIVPGYDFLVNSVWPEIVRGLEEKLPSLFNPGNPDVFHEKYTTSMDFVRKFERQCGSQASVRRLRSHPSYHSFNNKWNLPVYFQIRFREIAGALEAALSDSLEEAPEGSSYCLLATHMVWMSLLKCWSDQMFLPLLAHRLWKLSLQILSRYSVFINEVSVRPISSDNTKESKKLMPAGRKESSVNLSSNEDQGNGSSPENQSLPSISSTQLVYVAADLDKLQEKIPDILEMIKPKLEMIGFKNLSCIEGALEDSKTSLSACIPTLNNRIIQDLSESSFTYLKSALEIPRLYRRTNKEVPTKASSYVDSALKPFYRLQNEYRNILKQPMIHQWLEGALSESAQKYYETVSDVLSSVKKMEESLKRLKQARRTAALNPVGTNGGMSDDDKIRLQLALDVEYFGEQIRKMGLETNNIKSFSALTELVLTAKDQATAEQS", "length": 739 }, "evidence": [ { "id": "F1MQ89", "url": "https://omabrowser.org/oma/group/F1MQ89/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZT01-1", "protein_name": "Conserved oligomeric Golgi complex subunit 2", "gene_name": "Cog2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEKRRMNLPTGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALNQLSVPLGQLREEVLSLRSSVSEGILAVEERMSKQDDIRKKKMSVLRLIQVIRSVEKIEKILNSQSSKDASSQEASSPLLTGQVLERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSNVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYVSEVIVERVVDSHPSGLQLMYNKLLEFVPHHCRLLREVTGGAVSSEKGTIVPGYDFLVNSVWPEIVGGLEEKLPSLFNPGDPDAFHQKYTVSMDFVRRFERQCGSQASVKRLRAHPAYHSFSNKWNLPVYFQIRFREVAGSLEASLTDGLEDAPAGSPYCLLASHRTWISLSKCWSDEMFLPLLAHRLWRLTLQILARFSVFVSELSVRPISNETAKETKKPLAGSKDPSDDHGSHPSEAGAVPISSTQLVYVVSDLGRLQEWLPDLLETVRLKLEMVGFKNFSSISAALEDSQSALSAHVPALSSRIVQDLSESCFGYLKSALEVPRLYRRTNKEVPSTASSYVDSALKPLYQLQSGHGDKVQPAVMQRWLQEALSDSTHKYFETVSDVLSSVRKMEESLKRLKQARRSPATNPVSSSGGMSDDDKIRLQLALDVEHLGEQIQKMGLQTSDIKSFPALTELVLAARDQAAAEQP", "length": 730 }, "evidence": [ { "id": "F1MQ89", "url": "https://omabrowser.org/oma/group/F1MQ89/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F4JRR1-1", "protein_name": "Conserved oligomeric Golgi complex subunit 2", "gene_name": "COG2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MSDLVATSPSPSSAPRSATDFFSDPYDSHPLWFKPSLFLSPNFDSESYISELRTFVPFDTLRSELRSHLASLNRELVDLINRDYADFVNLSTKLVDIDAAVVRMRAPLLELREKITGFRGSVEAALFALRNGLQQRSDAAAAREVLELLLDTFHVVSKVEKLIKVLPSTPSDWQNEDANSMGRSSMNDENSTQQDGTTMRETQSMLLERIASEMNRLKFYMAHAQNLPFIENMEKRIQSASVLLDASLGHCFIDGLNNSDTSVLYNCLRAYAAIDNTNAAEEIFRTTIVAPFIQKIITHETTTNAAGTSEDELENDYKQIKHFIAKDCKMLLEISSTDKSGLHVFDFLANSILKEVLWAIQKVKPGAFSPGRPTEFLKNYKASLDFLAYLEGYCPSRSAVTKFRAEAICVEFMKQWNVGVYFSLRFQEIAGALDSALTSPSLVFIQDSDKESSLNLILRQSDTLLECLRSCWKEDVLVFSAADKFLRLTLQLLSRYSFWVSSALNNRKSNASPSPGCEWAVSATAEDFVYVIHDVNCLVSEVCGDYLGHISQYLSSSSTEVLDVVRISIEQGGVSLEKVLPLLTKTIIDVIVDKSVEDLRQLRGITATFRMTNKPLPVRHSPYVVGLLRPVKAFLEGDKARNYLTQKTKEELLHGSVSEITRRYYELAADVVSVARKTQSSLQKLRQNAQRRGGAASGVSDQNVSETDKMCMQLFLDIQEYGRNVSALGLKPADIPEYCSFWQCVAPADRQNSISV", "length": 756 }, "evidence": [ { "id": "F1MQ89", "url": "https://omabrowser.org/oma/group/F1MQ89/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q14746-1", "protein_name": "Conserved oligomeric Golgi complex subunit 2", "gene_name": "COG2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKSRMNLPKGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDKALNQLSVPLGQLREEVLSLRSSVSEGIRAVDERMSKQEDIRKKKMCVLRLIQVIRSVEKIEKILNSQSSKETSALEASSPLLTGQILERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSDVDIIRHCLRTYATIDKTRDAEALVGQVLVKPYIDEVIIEQFVESHPNGLQVMYNKLLEFVPHHCRLLREVTGGAISSEKGNTVPGYDFLVNSVWPQIVQGLEEKLPSLFNPGNPDAFHEKYTISMDFVRRLERQCGSQASVKRLRAHPAYHSFNKKWNLPVYFQIRFREIAGSLEAALTDVLEDAPAESPYCLLASHRTWSSLRRCWSDEMFLPLLVHRLWRLTLQILARYSVFVNELSLRPISNESPKEIKKPLVTGSKEPSITQGNTEDQGSGPSETKPVVSISRTQLVYVVADLDKLQEQLPELLEIIKPKLEMIGFKNFSSISAALEDSQSSFSACVPSLSSKIIQDLSDSCFGFLKSALEVPRLYRRTNKEVPTTASSYVDSALKPLFQLQSGHKDKLKQAIIQQWLEGTLSESTHKYYETVSDVLNSVKKMEESLKRLKQARKTTPANPVGPSGGMSDDDKIRLQLALDVEYLGEQIQKLGLQASDIKSFSALAELVAAAKDQATAEQP", "length": 738 }, "evidence": [ { "id": "F1MQ89", "url": "https://omabrowser.org/oma/group/F1MQ89/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q921L5-1", "protein_name": "Conserved oligomeric Golgi complex subunit 2", "gene_name": "Cog2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKRRMNLPTGPDTLCFDKDEFMKEDFDVDHFVSDCRKRVQLEELRDDLELYYKLLKTAMVELINKDYADFVNLSTNLVGMDRALNQLSVPLGQLREEVLSLRSSVSEGILAVDERMSKQEDIRKKKMSVLRLIQVIRSVEKIEKILNSQSSKDVSSQEASSPLLTGQVLERIATEFNQLQFHAVQSKGMPLLDKVRPRIAGITAMLQQSLEGLLLEGLQTSDVDIVRHCLRTYATIDKTQDAEALVGQVLVKPYVNEVIVEQFVESHPSSLQLMYNKLLEFVPHHCRLLREVTGGAVSSEKGTIVPGYDFLVNSVWPEIVRGLEEKLPSLFNPGDPDAFHQKYTVSMDFVQRFERQCGSQASVKRLRAHPAYHNFSNKWNLPVYFQIRFREVAGSLEAALTDGLEDAPAGSPYCLLASHRTWISLGKCWSDEMFLPLLAHRLWRLTLQILARFSVFVSELSVRPVSNESAKETKKPLTGSKDPSEDQGSHASEASAASISSTQLVYVVSDLGRLQEWLPDLLETVKQKLEMIGFKNFSSISAALEDSQSALSAHVPALSSRIVQDLSESCFSYLKSALEVPRLYRRTNKEVPSTASSYVDSALKPLYQLQSGHGDKVQPAVMQSWLQEALSDSTHRYFETVSDVLNSVKKMEESLKRLKQARRSPATNPVSSSGGGMSDDDKIRLQLALDVEHLGEQIQRMGLQTSDIKSFPALMELVLAARDQAAAEQP", "length": 731 }, "evidence": [ { "id": "F1MQ89", "url": "https://omabrowser.org/oma/group/F1MQ89/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VF78-1", "protein_name": "Conserved oligomeric Golgi complex subunit 2", "gene_name": "Cog2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MHDPVKKSAHLTAGSTSTAEKLCFDKNEFMKANFSVDEFLHKNRNAPSLEQLRDNLGLYLKGLRAAMIDLINEDYADFVNLSANLVGLDQNIKTIQQPLEQFRSDIESIHGLIDENVTELRAQLEEKRQLREFKRGLQSLKKVYETINKLQDLIDRKLSGEQPIKAVDLERAALDLIQLKFHEKHCFKHLSPDHQGKIQQLEEQLHQHLRRFFNDALSQARNSAPESLERCLRIYITLNACDQAECAFREDVVAPYMTGVIGEQQLQNSPQGLAGIYSKILNFISLHMTDLLRLTLYSDKFPGFNFVVNSYWSDVETRLELHMNSIFAPGNSEVFYVKYKCTRDFLGKIEELLTCSGEQAVTFYRQHKQTKSFEARWNLPVYFQICFQEIAGKFEAQLEPVLQEDSLKDNLTDSDYKISAFNAAKEAMTRCWAEGVYLPEVFPKFYKLNVQVVLRLSRWITDAITQSKGSNFSKPYTRNQLLIALHADIRKLDAHLPELQQLIIKSVPVEQCTKIFSDVLAKSMSCLADTLGAHLTNIQKTLVELLIGECETENVRQVNDLPRLYRKTNREVPTRCSSYVEQMLRPLKAFAQQNESQLGTLVVEQILAEVASHITKAYFNVVSDVLTSVQKTEESLRRLRNVKSGGAATVSTGSSAVMSDDDKIRVQLRVDVTSWRQELCKLNFQATQIDKLVELTNMVEDSIKLKDNSA", "length": 710 }, "evidence": [ { "id": "F1MQ89", "url": "https://omabrowser.org/oma/group/F1MQ89/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "F1MQ89", "url": "https://www.uniprot.org/uniprotkb/F1MQ89" } ], "pmid": "" }, { "name": "Golgi stack", "id": "GO:0005795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005795", "evidence": [ { "database": "UniProtKB", "id": "F1MQ89", "url": "https://www.uniprot.org/uniprotkb/F1MQ89" } ], "pmid": "" }, { "name": "Golgi transport complex", "id": "GO:0017119", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017119", "evidence": [ { "database": "UniProtKB", "id": "F1MQ89", "url": "https://www.uniprot.org/uniprotkb/F1MQ89" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "F1MQ89", "url": "https://www.uniprot.org/uniprotkb/F1MQ89" } ], "pmid": "" }, { "name": "Golgi organization", "id": "GO:0007030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007030", "evidence": [ { "database": "UniProtKB", "id": "F1MQ89", "url": "https://www.uniprot.org/uniprotkb/F1MQ89" } ], "pmid": "" }, { "name": "retrograde transport, vesicle recycling within Golgi", "id": "GO:0000301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000301", "evidence": [ { "database": "UniProtKB", "id": "F1MQ89", "url": "https://www.uniprot.org/uniprotkb/F1MQ89" } ], "pmid": "" }, { "name": "intra-Golgi vesicle-mediated transport", "id": "GO:0006891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006891", "evidence": [ { "database": "UniProtKB", "id": "F1MQ89", "url": "https://www.uniprot.org/uniprotkb/F1MQ89" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 468, "end_pos": 470, "annotation": "n_glycosylation_sequon" }, { "start_pos": 545, "end_pos": 547, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MQ89-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 739, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MQ89-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MQ89" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MQ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ89" }, { "id": "PF12022", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12022" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "COG complex component COG2 C-terminal", "eco_id": "ECO_0000259", "start_pos": 378, "end_pos": 700, "start_aa": "Asn", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MQ89", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ89" }, { "id": "PF06148", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06148" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Conserved oligomeric Golgi complex subunit 2 N-terminal", "eco_id": "ECO_0000259", "start_pos": 15, "end_pos": 88, "start_aa": "Leu", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 468, "end_pos": 470 }, { "start_pos": 545, "end_pos": 547 }, { "start_pos": 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MLK9-1", "uniprot_ac": "F1MLK9", "uniprot_id": "F1MLK9_BOVIN", "mass": { "chemical_mass": 27026.0, "monoisotopic_mass": 27026.0 }, "refseq": {}, "gene_names": [ { "name": "HSCB", "type": "recommended", "evidence": [ { "id": "F1MLK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLK9" } ] } ], "protein_names": [ { "name": "Iron-sulfur cluster co-chaperone protein HscB", "type": "recommended", "evidence": [ { "id": "F1MLK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLK9/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Plays an essential role in hematopoiesis.", "evidence": [ { "database": "UniProtKB", "id": "F1MLK9", "url": "https://www.uniprot.org/uniprotkb/F1MLK9#function" }, { "database": "UniProtKB", "id": "ARBA00054586", "url": "https://www.uniprot.org/uniprotkb/ARBA00054586#function" } ] }, { "annotation": "Acts as a co-chaperone in iron-sulfur cluster assembly in the cytoplasm. Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1. This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT.", "evidence": [ { "database": "UniProtKB", "id": "F1MLK9", "url": "https://www.uniprot.org/uniprotkb/F1MLK9#function" }, { "database": "UniProtKB", "id": "ARBA00058496", "url": "https://www.uniprot.org/uniprotkb/ARBA00058496#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MLK9", "url": "https://www.uniprot.org/uniprotkb/F1MLK9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "HSCB", "url": "https://www.uniprot.org/uniprotkb/F1MLK9", "locus": { "chromosome": "17", "start_pos": 68025487, "end_pos": 68012848, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000015075", "url": 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"database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036869", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040682", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040682", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "LMFIERF", "url": "https://omabrowser.org/oma/group/LMFIERF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MLK9", "url": "https://www.orthodb.org/?gene=F1MLK9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14021", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14021", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14021:SF15", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14021:SF15", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07743", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07743", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF18256", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF18256", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-1268020", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1268020", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-1362409", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1362409", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-9865881", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9865881", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0AAA9TS73", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS73", 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"header": "tr|F1MLK9-1|F1MLK9_BOVIN Isoform 1 of Iron-sulfur cluster co-chaperone protein HscB OS=Bos taurus OX=9913 GN=HSCB PE=3 SV=1 CANONICAL=F1MLK9-1" }, "isoforms": [ { "isoform_ac": "A0AAA9TS73-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TS73/entry", "sequence": { "sequence": "MWGGRTGAFLRPSGWWPTGVLGRRLLNCNAASLAGSSSPRCWNCGGPGGPPRGDRFFCPQCRALQPPDPTRDYFSLMDCNRSFRVDTVKLQHRYQQLQRLVHPDFFSQRSQNEKDFSEKHSTLVNEAYKTLLAPLSRGLYLVS", "length": 143, "header": "tr|A0AAA9TS73-1|F1MLK9_BOVIN Computationally mapped isoform of Iron-sulfur cluster co-chaperone protein HscB OS=Bos taurus OX=9913 GN=HSCB PE=3 SV=1 CANONICAL=F1MLK9-1" }, "locus": { "chromosome": "17", "start_pos": 68022101, "end_pos": 68012888, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000126168.2", "url": "https://www.ensembl.org/id/ENSBTAT00000126168.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000100191.1", "url": "https://www.ensembl.org/id/ENSBTAP00000100191.1" } ] } }, { "isoform_ac": "A0AAA9U1K1-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1K1/entry", "sequence": { "sequence": "MWGGRTGAFLRPSGWWPTGVLGRRLLNCNAASLAGSSSPRCWNCGGPGGPPRGDRFFCPQCRALQPPDPTRDYFSLMDCNRSFRVDTVKLQHRYQQLQRLVHPDFFSQRSQNEKDFSEKHSTLVNEAYKTLLAPLSRGLYLLKLRGIEIPEGTDYEMDSQFLTEIMEINEKLAEAQGEIAMKEIESIVRDNFEKAKELLTKMRYFSNIEEKIKLKKIPL", "length": 219, "header": "tr|A0AAA9U1K1-1|F1MLK9_BOVIN Computationally mapped isoform of Iron-sulfur cluster co-chaperone protein HscB OS=Bos taurus OX=9913 GN=HSCB PE=3 SV=1 CANONICAL=F1MLK9-1" }, "locus": { "chromosome": "17", "start_pos": 68023650, "end_pos": 68012888, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000099616.2", "url": "https://www.ensembl.org/id/ENSBTAT00000099616.2" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000103103.1", "url": "https://www.ensembl.org/id/ENSBTAP00000103103.1" } ] } }, { "isoform_ac": "F1MLK9-1", "url": "https://www.uniprot.org/uniprotkb/F1MLK9/entry", "sequence": { "sequence": "MWGGRTGAFLRPSGWWPTGVLGRRLLNCNAASLAGSSSPRCWNCGGPGGPPRGDRFFCPQCRALQPPDPTRDYFSLMDCNRSFRVDTVKLQHRYQQLQRLVHPDFFSQRSQNEKDFSEKHSTLVNEAYKTLLAPLSRGLYLLKLRGIEIPEGTDYEMDSQFLTEIMEINEKLAEAQGEIAMKEIESIVRAKQKELTDDVSRAFERDNFEKAKELLTKMRYFSNIEEKIKLKKIPL", "length": 235, "header": "tr|F1MLK9-1|F1MLK9_BOVIN Isoform 1 of Iron-sulfur cluster co-chaperone protein HscB OS=Bos taurus OX=9913 GN=HSCB PE=3 SV=1 CANONICAL=F1MLK9-1" }, "locus": { "chromosome": "17", "start_pos": 68023650, "end_pos": 68012888, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000044111.4", "url": "https://www.ensembl.org/id/ENSBTAT00000044111.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041625.2", "url": "https://www.ensembl.org/id/ENSBTAP00000041625.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-1268020", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1268020", "resource": "Reactome", "description": "Mitochondrial protein import" }, { "id": "R-BTA-1362409", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-1362409", "resource": "Reactome", "description": "Mitochondrial iron-sulfur cluster biogenesis" }, { "id": "R-BTA-6799198", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-6799198", "resource": "Reactome", "description": "Complex I biogenesis" }, { "id": "R-BTA-9865881", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9865881", "resource": "Reactome", "description": "Complex III assembly" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AIR5-1", "protein_name": "Iron-sulfur cluster co-chaperone protein HscB", "gene_name": "HSCB", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MWGGRTGALLRLSRLWPTGLLWRGLLNCNVVSLAGSNSPRCWNCGGLGGPLRGDQFFCPQCRALQPPDPARDYFSLMDCNHSFRVDTSKLQHRYQELQRLVHPDFFSQRSQTEKDFSEKHSTLVNDAYKTLLAPLSRGLYLLKLHGIEIPEGTDHEMDSQFLMEIMEINEKLAEAQSETAMNEIESVVRAKQKELTDNVSRAFERDDFEKAKELLTKMRYFSNIEEKIKLKKIPL", "length": 235 }, "evidence": [ { "id": "F1MLK9", "url": "https://omabrowser.org/oma/group/F1MLK9/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6A2K9-1", "protein_name": "HscB mitochondrial iron-sulfur cluster co-chaperone", "gene_name": "Hscb", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MWSCRARSLLCVWEVRLARFLGRSLLSSNAASGKSIEPQCWNCGRAMGAGRGDEFFCAHCRALQPPDPTRDYFSLMNCNQSFRVDIRKLQQRYQQLQRLVHPDFFSQKSQTEKRFSEKHSTLVNDAYKTLQAPVSRGLYLLKLQGIEIPEGTDYRTDSQFLVEIMEINEKLADAKSEAAMEEVEATVREPSFCNEQPWGSEVAAPALPLALPLLQYDGMEMFSFSWLASHYWFSKHLLNRKNLRTI", "length": 246 }, "evidence": [ { "id": "F1MLK9", "url": "https://omabrowser.org/oma/group/F1MLK9/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A8JNT7-1", "protein_name": "Heat shock protein cognate 20", "gene_name": "Hsc20", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSRVINGFKSAVKATNYTPLVRNAAQFNQFQLPEIRKFSVESSPACWNCQKKSELKQNMICSDCGHLQDVNSGINYFKLLSFPIQFSLESQKLTRSFRQLQTIVHPDKYSNKTSREQTNSSDWSSLINKAYKTLSTPIDRGQYLLQLEGEQMPQDNSALNKEFLMAMMERNEEVEDAEDTQTLENLNIQLIKELEEMARKLNALFDSKDLSGVKETLVEMKYLLSIQNSIKQKQQSLLGS", "length": 240 }, "evidence": [ { "id": "F1MLK9", "url": "https://omabrowser.org/oma/group/F1MLK9/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "F1N857-1", "protein_name": "Iron-sulfur cluster co-chaperone protein HscB", "gene_name": "HSCB", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MRAALRRQFGRARWALRVSEAAPRPRCVGPGSVPSPRCWSCGGALSGADAAPHFCPRCRALQPPAPRPDLFRLMECERSFRVDAQRLQRRFRSLQRALHPDRFGRRPPKEQHYSEQHSSLINKAYQTLLHPLSRGLYLLELNGVEPAQETDCDADSEFLTEIMEINEKLAEPENDEILAEIETLIKDRQEELTKEVTAAFERDDLQEAKKLLAKMKYFANLEDKLKNKKIPS", "length": 232 }, "evidence": [ { "id": "F1MLK9", "url": "https://omabrowser.org/oma/group/F1MLK9/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HCC2-1", "protein_name": "Iron-sulfur cluster co-chaperone protein HscB", "gene_name": "Hscb", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MWGCRARALVCVWEVRLAGFLGRRLLSSNAASGKSNAGQCWNCGSAGGVESGDGFFCEHCRALQPPDPTRDYFSLMNCHRSFRVDVMKLQHRYQQLQRLVHPDFFSQKSQTEKHFSEKHSTLVNDAYKTLQAPLSRGLYLLKLQGIEIPEGTDYGRDSQFLMEIMEINEKLADAQSEAAMEEIESTVRAKQKEFTDGVNRAFEQGDFEKAKEILTKMKYFSNIEEKIKLSKNPL", "length": 234 }, "evidence": [ { "id": "F1MLK9", "url": "https://omabrowser.org/oma/group/F1MLK9/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "Q8IWL3-1", "protein_name": "Iron-sulfur cluster co-chaperone protein HscB", "gene_name": "HSCB", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MWRGRAGALLRVWGFWPTGVPRRRPLSCDAASQAGSNYPRCWNCGGPWGPGREDRFFCPQCRALQAPDPTRDYFSLMDCNRSFRVDTAKLQHRYQQLQRLVHPDFFSQRSQTEKDFSEKHSTLVNDAYKTLLAPLSRGLYLLKLHGIEIPERTDYEMDRQFLIEIMEINEKLAEAESEAAMKEIESIVKAKQKEFTDNVSSAFEQDDFEEAKEILTKMRYFSNIEEKIKLKKIPL", "length": 235 }, "evidence": [ { "id": "F1MLK9", "url": "https://omabrowser.org/oma/group/F1MLK9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8K3A0-1", "protein_name": "Iron-sulfur cluster co-chaperone protein HscB", "gene_name": "Hscb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWGCGARALLGVWEVRLAGFLGRRLLGSNAAAGKSIAPQCWNCGHAREAGCGDEFFCSHCRALQPPDPTRDYFSLMNCNRSFRVDVTKLQHRYQQLQRLVHPDFFSQKSQTEKHFSDKHSTLVNDAYKTLQAPLTRGLYLLKLQGIEIPEGTDYKADSQFLVEIMEINERLADAQSEAAMEEIEATVRAKQKEFTDNINSAFEQGDFEKAKELLTKMRYFSNIEEKIKLSKTPL", "length": 234 }, "evidence": [ { "id": "F1MLK9", "url": "https://omabrowser.org/oma/group/F1MLK9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "F1MLK9", "url": "https://www.uniprot.org/uniprotkb/F1MLK9" } ], "pmid": "" }, { "name": "ATPase activator activity", "id": "GO:0001671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001671", "evidence": [ { "database": "UniProtKB", "id": "F1MLK9", "url": "https://www.uniprot.org/uniprotkb/F1MLK9" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1MLK9", "url": "https://www.uniprot.org/uniprotkb/F1MLK9" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "F1MLK9", "url": "https://www.uniprot.org/uniprotkb/F1MLK9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "[2Fe-2S] cluster assembly", "id": "GO:0044571", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044571", "evidence": [ { "database": "UniProtKB", "id": "F1MLK9", "url": "https://www.uniprot.org/uniprotkb/F1MLK9" } ], "pmid": "" }, { "name": "protein complex oligomerization", "id": "GO:0051259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051259", "evidence": [ { "database": "UniProtKB", "id": "F1MLK9", "url": "https://www.uniprot.org/uniprotkb/F1MLK9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "F1MLK9", "url": "https://www.uniprot.org/uniprotkb/F1MLK9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MLK9", "url": "https://www.uniprot.org/uniprotkb/F1MLK9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 80, "end_pos": 82, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MLK9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 235, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MLK9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MLK9" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MLK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLK9" }, { "id": "SM00271", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00271" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000259", "start_pos": 71, "end_pos": 136, "start_aa": "Arg", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 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"Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035507", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035507", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MMC7", "url": "https://www.orthodb.org/?gene=F1MMC7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13140", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13140", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13140:SF663", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13140:SF663", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00018", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00018", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00063", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00063", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF06017", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06017", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "A0AAA9TWY2", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWY2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AAA9TWY2-1", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWY2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MMC7", 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"length": 1069, "header": "tr|A0AAA9TWY2-1|F1MMC7_BOVIN Computationally mapped isoform of Myosin IF OS=Bos taurus OX=9913 GN=MYO1F PE=3 SV=1 CANONICAL=F1MMC7-1" }, "locus": { "chromosome": "7", "start_pos": 17157610, "end_pos": 17120432, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000114979.1", "url": "https://www.ensembl.org/id/ENSBTAT00000114979.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000101975.1", "url": "https://www.ensembl.org/id/ENSBTAP00000101975.1" } ] } }, { "isoform_ac": "F1MMC7-1", "url": "https://www.uniprot.org/uniprotkb/F1MMC7/entry", "sequence": { "sequence": "MGSKERFHWQSHNVKQSGVDDMVLLPQITEDGIVGNLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYKVDGTDDRSDFSETLALCPMCLQSAMQVIGIPANVQELVLQLVAGILHLGNISFCEDGNYARVESADLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESIDVTLNVEQAAYTRDALAKGLYSRLFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIQYFNNKIVCDLIENKLNPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGNHEHFNSWSAGFVIHHYAGKVSYDVNGFCERNRDVLFSDLIELMQTSEQAFLRMLFPEKLDVEKKGRPSTAGSKIKKQANDLVSTLKRCTPHYIRCIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPYWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEMRERKFDGFARTIQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKRERVDFADSVNKYDRRFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVREVLKKKLEIQALRGVSLSTRQDDFFILQEDAADSFLESIFKTEFVSLLCKRFEEAVRRPLALTFSDTLQFRVKKEGWGGGGTRSVTFSRGSGDVAVLKASGKALTVSVGDGLPKSSKPTRKGMAQGKSRRPGQTATRAAPGPPRGLDRNGVPPSARRGPLPMEITSGGGSQRPPRGPPSSALGASRRPRARPPSEHNTEFLNVPDQGVAGMQRKRSVGQRPVPGVGRPKPQPRIHGPRCRALYQYVGQDVDELSFNVNEVIEILMEDSSGWWKGRLHGQEGLFPGNYVEKI", "length": 1106, "header": "tr|F1MMC7-1|F1MMC7_BOVIN Isoform 1 of Myosin IF OS=Bos taurus OX=9913 GN=MYO1F PE=3 SV=3 CANONICAL=F1MMC7-1" }, "locus": { "chromosome": "7", "start_pos": 17157610, "end_pos": 17120432, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010081.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010081.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010081.6", "url": "https://www.ensembl.org/id/ENSBTAP00000010081.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "F1MMC7", "url": "https://www.uniprot.org/uniprotkb/F1MMC7" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "F1MMC7", "url": "https://www.uniprot.org/uniprotkb/F1MMC7" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MMC7", "url": "https://www.uniprot.org/uniprotkb/F1MMC7" } ], "pmid": "" }, { "name": "cytoskeletal motor activity", "id": "GO:0003774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003774", "evidence": [ { "database": "UniProtKB", "id": "F1MMC7", "url": "https://www.uniprot.org/uniprotkb/F1MMC7" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "F1MMC7", "url": "https://www.uniprot.org/uniprotkb/F1MMC7" } ], "pmid": "" }, { "name": "microfilament motor activity", "id": "GO:0000146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000146", "evidence": [ { "database": "UniProtKB", "id": "F1MMC7", "url": "https://www.uniprot.org/uniprotkb/F1MMC7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "myosin complex", "id": "GO:0016459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016459", "evidence": [ { "database": "UniProtKB", "id": "F1MMC7", "url": "https://www.uniprot.org/uniprotkb/F1MMC7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MMC7", "url": "https://www.uniprot.org/uniprotkb/F1MMC7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MMC7", "url": "https://www.uniprot.org/uniprotkb/F1MMC7" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MMC7", "url": "https://www.uniprot.org/uniprotkb/F1MMC7" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "F1MMC7", "url": "https://www.uniprot.org/uniprotkb/F1MMC7" } ], "pmid": "" }, { "name": "microvillus", "id": "GO:0005902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005902", "evidence": [ { "database": "UniProtKB", "id": "F1MMC7", "url": "https://www.uniprot.org/uniprotkb/F1MMC7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "F1MMC7", "url": "https://www.uniprot.org/uniprotkb/F1MMC7" } ], "pmid": "" }, { "name": "actin filament organization", "id": "GO:0007015", "url": 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protein 629 OS=Bos taurus OX=9913 GN=ZNF629 PE=3 SV=1 CANONICAL=F1MTC4-1" }, "locus": { "chromosome": "25", "start_pos": 26904945, "end_pos": 26900552, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000100524.1", "url": "https://www.ensembl.org/id/ENSBTAT00000100524.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000102185.1", "url": "https://www.ensembl.org/id/ENSBTAP00000102185.1" } ] } }, { "isoform_ac": "F1MTC4-1", "url": "https://www.uniprot.org/uniprotkb/F1MTC4/entry", "sequence": { "sequence": "MWALSLTLSLLPRTAEFEFFQRHQGSLEHWTALSSGMEPETALWGPDLQDPGQSPDDGHPGAESGNEEESTQHESSGEEVILGDPDQSPEFKDPSEMPLETPSQDASGPQDAPAPLGHANPSDHQTPLDTPSPEVVPTPSDWTKACEASWQWGTLTTWNSPPVVPANEPSLRELVQGRPAGAEKPYICNECGKSFSQWSKLLRHQRIHTGERPNTCSECGKSFTQSSHLVQHQRTHTGEKPYKCPDCGKCFSWSSNLVQHQRTHTGEKPYKCTECEKAFTQSTNLIKHQRSHTGEKPYKCGECRRAFYRSSDLIQHQATHTGEKPYKCPECGKRFGQNHNLLKHQKIHAGEKPYRCTECGKSFIQSSELTQHQRTHTGEKPYECLECGKSFGHSSTLIKHQRTHLREDPFKCPVCGKTFTLSATLLRHQRTHTGERPYKCPECGKSFSVSSNLINHQRIHRGERPYICADCGKSFIMSSTLIRHQRIHTGEKPYKCSDCGKSFIRSSHLIQHRRTHTGEKPYKCPECGKSFSQSSNLITHVRTHMDENLFVCSDCGKAFLEAHELEQHRVIHERGKTPARRAQGDGLLGLGDPALLTPPPGAKPHKCLVCGKGFNDEGIFMQHQRIHIGENPYKNSDGLPAHPAPKPPQFRSPRLPFGGNSFPGAAEGRADPPGQPFKMPDGQESFSHRLGLPSSKSYICSHCGESFLDRSVLLQHQVTHGNEKPYLFPDYRIGLGEGAGPSPFLSGKPFKCPECKKSFALSSELLLHQKVHAGGKAQKSPELGKSSSVLLEHLRSPLGARPYSCSDCGASFLDRLALIRHQETHTQEKSPIPEDPLPEPATLSTSQEGEGEAPAPTESSSHEEGGSPKTSLEEKPYLCPECGDGFTEVSALLLHRSCHPGVTL", "length": 904, "header": "tr|F1MTC4-1|F1MTC4_BOVIN Isoform 1 of Zinc finger protein 629 OS=Bos taurus OX=9913 GN=ZNF629 PE=3 SV=3 CANONICAL=F1MTC4-1" }, "locus": { "chromosome": "25", "start_pos": 26906744, "end_pos": 26902187, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000037326.5", "url": "https://www.ensembl.org/id/ENSBTAT00000037326.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000037160.4", "url": "https://www.ensembl.org/id/ENSBTAP00000037160.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 138, "start_aa": "Thr", "end_pos": 138, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr138", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 857, "start_aa": "Thr", "end_pos": 857, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr857", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MTC4", "url": "https://www.uniprot.org/uniprotkb/F1MTC4" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MTC4", "url": "https://www.uniprot.org/uniprotkb/F1MTC4" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "F1MTC4", "url": "https://www.uniprot.org/uniprotkb/F1MTC4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MTC4", "url": "https://www.uniprot.org/uniprotkb/F1MTC4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MTC4", "url": "https://www.uniprot.org/uniprotkb/F1MTC4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MTC4", "url": "https://www.uniprot.org/uniprotkb/F1MTC4" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MTC4", "url": "https://www.uniprot.org/uniprotkb/F1MTC4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MTC4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 904, "overlap": "1.0", "method": 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"MEKLDTNISEEGRSCYLSEHYKQVYLSLTYSIIFVLGLPLNGAVLWLSWRQTKRWSCATIYLANLMVADLLYISTLPFLIVTYSLEDTWPFGELLCKLVRFLFYANLYSSVLLLTCISVHRFLGVCHPLRSLPYRTRRHALLGATATWALVVIQLLPTLIFSHTDDIDGQMICYDTTSADHFDKFFVYSMVLMLSSFVLPSLVILVCYSLMVRSLATPVETLTRVGGATRAKSIRIILLVCGLFALCFVPFHISRSLYFTLRFLSSGNCQLLTVVSLAYKVWRPLVSLSSCLNPVLYFLSGGNRVRLFQELGHNKVGEHPAGAKGQRLWAVSCPPRGGQVWVLPR", "length": 345, "header": "tr|F1MJM2-1|F1MJM2_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC101901911 PE=3 SV=3 CANONICAL=F1MJM2-1" }, "isoforms": [ { "isoform_ac": "F1MJM2-1", "url": "https://www.uniprot.org/uniprotkb/F1MJM2/entry", "sequence": { "sequence": "MEKLDTNISEEGRSCYLSEHYKQVYLSLTYSIIFVLGLPLNGAVLWLSWRQTKRWSCATIYLANLMVADLLYISTLPFLIVTYSLEDTWPFGELLCKLVRFLFYANLYSSVLLLTCISVHRFLGVCHPLRSLPYRTRRHALLGATATWALVVIQLLPTLIFSHTDDIDGQMICYDTTSADHFDKFFVYSMVLMLSSFVLPSLVILVCYSLMVRSLATPVETLTRVGGATRAKSIRIILLVCGLFALCFVPFHISRSLYFTLRFLSSGNCQLLTVVSLAYKVWRPLVSLSSCLNPVLYFLSGGNRVRLFQELGHNKVGEHPAGAKGQRLWAVSCPPRGGQVWVLPR", "length": 345, "header": "tr|F1MJM2-1|F1MJM2_BOVIN Isoform 1 of G-protein coupled receptors family 1 profile domain-containing protein OS=Bos taurus OX=9913 GN=LOC101901911 PE=3 SV=3 CANONICAL=F1MJM2-1" }, "locus": { "chromosome": "1", "start_pos": 108696998, "end_pos": 108695964, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025466.7", "url": "https://www.ensembl.org/id/ENSBTAT00000025466.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025466.6", "url": "https://www.ensembl.org/id/ENSBTAP00000025466.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], 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family 1 profile domain-containing protein", "gene_name": "ENSRNOG00000066920", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "TLLFFPPWSLDVNVSEDEGFCHFSESYKQVYLSLTYSLIFMLGMPLNGAVLWLSWCQTKPWSCTTIYLMNLMVADLLYMLSLPFLIITYAAGDTWLFGETLCRLVRFLFYTNLYSSILLLTCISLYRFLGVCHPLSSLSFRTHRHTWQAAATTWTLVVVQLLPTLVFSHTDYVNGHVICYDTASPENFDHFFAYSMVLTLSGFVFPSLIILGCYSLMVRSLTNPAEDLPTTGHAARAKSIRTILLVCSLFMLCFVPFHIARSFYLVIRFLNSQDCQLLLAASMAYKICRPLVSASSCLNPVLYFLSQGNNRVQLLQKLRQNKVGEHPTSVEGARRSRQIQKELDTDQTRAS", "length": 351 }, "evidence": [ { "id": "F1MJM2", "url": "https://omabrowser.org/oma/group/F1MJM2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MJM2", "url": 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Pathway" ] }, { "id": "F1MJN1", "url": "https://www.orthodb.org/?gene=F1MJN1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1MJN7", "url": "https://www.orthodb.org/?gene=F1MJN7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15577", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15577", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15577:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15577:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF27978", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF27978", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MJN1", "url": "https://www.uniprot.org/uniprotkb/F1MJN1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJN1-1", "url": "https://www.uniprot.org/uniprotkb/F1MJN1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJN7", "url": "https://www.uniprot.org/uniprotkb/F1MJN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJN7-1", "url": "https://www.uniprot.org/uniprotkb/F1MJN7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MYRSGARSSVSSHRPKESGGGDPRTGRSSGSSSGPARRTSPPSSCSSSSRTPARRPRSPSGHRGRRASPSPPRGRRASPSPPRGRRASPSPPRGRRGSPSPPRARRGSPSPPRGRRLFPPGSAGFRGSSRGESRADFARDGRGDHPGDSGSRRRSPGLRSDSSLEQSLRITVGNDHFCVGIPERRRLSDRLGSPVENLEDADRDDLTDDSVFTRSSQCSRGLERYISREEAPLSPFLGQLDEDYRARETFLHRSDYSPHISCHDDLLRGTERNRDKLKGSYSIRPEESSREAKRPRYDDTEKMHNMGSDHPSFTSGTRNYRQRRRSPSPRFLDPEFRELDLARRKREEEEERSRSLSQELVGVDSGGTSCPIPGLSGVLTASEPGYSLHRPEEVSVMPKKSILKKRIEVDMEPSLQLESFPSSTSSSQDHPLYSGHSSLPLSGAIAAFASEVENNKGTMVETTLKESQGNLYQWGPLPGIPKDNSPLREKFGSFLCHKEKLDMKAEGPERHTDFLLPHERASQDGSGFSCILSMLADSTSTQEKRRLSFPDIEDEEKFLYGDEEEDLKAESPPKPLGSSESEVMRQKASSLPSSAPTVKLESIEETNPEYAKIHDLLKTIGLDIGVAEISKLAARTQERLHGKKPSGSSADRRSSADRHFPADRCSSVDHRFSADRRSADPHRLESVEVHHSNTHSPEVSRPHQVSPVDPYLLTKNSPPFLKSDHPMGHIVGPEVVGSGFQSSVAVRCMLPSAPSAPVRLPHPASLSQFHVPRASQFAAARIPPNYQGPAIPPASFDAYRHYMAYAASRWPMYPASQPSNHPLPDSHRTVPVSKQATRSRPNLRVIPTVTPDEPKHEESVLGSIPTAQVPVHVSIPSLIRYNPEKISDEKNRASQKQKVIEEREKLKSDREARQKKMYYLRTELERLHKQQAQEHHRNDAKFVTGVDLSHAGDVNFDHLVKMMSAKFLHCKVTILPFSIREMLRKKRREKDGHKDPLLVEVSRLQDNIMKDIADLRQEAEEAEKKQSELDKVAQILGINISDKSQKSSSDSREPTEKTGKAEKSKSPEKVSSSSNSSSNCKESKVNSENSHTKSPKPAESPQPAKQSDQPVAAYEYYDAGNHWCKDCNTICGTMFDFFTHMHNKKHTQTLDPYNRPWASKTQNEAKQDAVKRTDKITVPAKGSEFLIPITGYYCQLCEEFLGDPISGEQHVKGYQHNEKYKKYVVENPLYEERRNLDRQAGLAVVLETERRRQSELKRKFSERPKEEKKEKQAKIMKEVKEDDRVSEELEDQLSEGRNSPEKAENRKRPSIKLQLKEEIKKEPPISSSFGKFSWKKPEKEEEKSLVIPSIPKEEIVESGKDKEDGKADPGKTKPIKIKLSGKTVVAHTSPWMPVVTTSTQTKIRPNLPIPSTVLRKSGSATVSKPAPLNTFLSIKSSGTTAKPLPVVKESSADLLLPPDIISKAFGGEEVILKGSPEEKMVLAEKNEPSHIPEQMLPPPPPPPPPPPPPPPVIPHPASPSPAQANAILAPVKSNPAVSHTVIPGFLGPNILNPVLPVAIMASAQPTAIPSDETAPGVSESDRDQTLFSVLVRPPPPLSSVFSEQAKKLEKRNSCLATANAKDLYDIFYSSGGKGAPETKLSGGPLANGENRAENSDASSTSTLNSSASQEELPSGRNLVSAPMVSSSEKPISKPLVSLGRLSAVENVDSKNRGSSYGFLQPLTRLCQNRPYETITPKTETLAKWASGSFQSDANKDVAPVRKIELDLGDPGPPGVEPASELSDTKCHTMQSQKLVETHLGESSKQQSQELHQPKDCGKSEVETSTELKEEGVKLSERTVREGTDINVGPNSIEDSNLNSGNRCMWEEEVEQPNLHRTDKKAKQSRKLITESKTQGKVVPELKTQTVSSTKAKIDSFPSEVRSLLQNPQDVKISAPELLLQSPYRSDMCLKDHEQKQGVPACSEEWLENSAPESASRTSRYRSLKLKRERSKDLQGKMTYKLTDWDENKNPETWESPEKPKAEALEPRDVHPELTVTIESKALENFEVTDLKVEELAALGSLGDIGVDFCNTRVDPAHRSPVALSQKVCEENSVSPLGGNPSSLTDFEPIPSFSEFPLDSPKTLVLNFGAEGEQNSSNPRTGRIAPNILKTGLPIENVGLGLGNLEGTHQALDLLAGGMMPEEIEETSKLEKQDSLRLESETINPLCLGPSPCLPDLVDFVTRTSGVQKEKICSPLSEPGDPPECSSLEMGLLQLEIPNASITEVAVPQVDEYSDNPLNVVKSVASGSHTRERVAGGSTIPQEIAAQEAAVDALQDHTESSVHS", "length": 2323, "header": "tr|F1MJN1-1|F1MJN1_BOVIN Isoform 1 of Zinc finger protein 318 OS=Bos taurus OX=9913 GN=ZNF318 PE=4 SV=4 CANONICAL=F1MJN1-1" }, "isoforms": [ { "isoform_ac": "F1MJN1-1", "url": "https://www.uniprot.org/uniprotkb/F1MJN1/entry", "sequence": { "sequence": "MYRSGARSSVSSHRPKESGGGDPRTGRSSGSSSGPARRTSPPSSCSSSSRTPARRPRSPSGHRGRRASPSPPRGRRASPSPPRGRRASPSPPRGRRGSPSPPRARRGSPSPPRGRRLFPPGSAGFRGSSRGESRADFARDGRGDHPGDSGSRRRSPGLRSDSSLEQSLRITVGNDHFCVGIPERRRLSDRLGSPVENLEDADRDDLTDDSVFTRSSQCSRGLERYISREEAPLSPFLGQLDEDYRARETFLHRSDYSPHISCHDDLLRGTERNRDKLKGSYSIRPEESSREAKRPRYDDTEKMHNMGSDHPSFTSGTRNYRQRRRSPSPRFLDPEFRELDLARRKREEEEERSRSLSQELVGVDSGGTSCPIPGLSGVLTASEPGYSLHRPEEVSVMPKKSILKKRIEVDMEPSLQLESFPSSTSSSQDHPLYSGHSSLPLSGAIAAFASEVENNKGTMVETTLKESQGNLYQWGPLPGIPKDNSPLREKFGSFLCHKEKLDMKAEGPERHTDFLLPHERASQDGSGFSCILSMLADSTSTQEKRRLSFPDIEDEEKFLYGDEEEDLKAESPPKPLGSSESEVMRQKASSLPSSAPTVKLESIEETNPEYAKIHDLLKTIGLDIGVAEISKLAARTQERLHGKKPSGSSADRRSSADRHFPADRCSSVDHRFSADRRSADPHRLESVEVHHSNTHSPEVSRPHQVSPVDPYLLTKNSPPFLKSDHPMGHIVGPEVVGSGFQSSVAVRCMLPSAPSAPVRLPHPASLSQFHVPRASQFAAARIPPNYQGPAIPPASFDAYRHYMAYAASRWPMYPASQPSNHPLPDSHRTVPVSKQATRSRPNLRVIPTVTPDEPKHEESVLGSIPTAQVPVHVSIPSLIRYNPEKISDEKNRASQKQKVIEEREKLKSDREARQKKMYYLRTELERLHKQQAQEHHRNDAKFVTGVDLSHAGDVNFDHLVKMMSAKFLHCKVTILPFSIREMLRKKRREKDGHKDPLLVEVSRLQDNIMKDIADLRQEAEEAEKKQSELDKVAQILGINISDKSQKSSSDSREPTEKTGKAEKSKSPEKVSSSSNSSSNCKESKVNSENSHTKSPKPAESPQPAKQSDQPVAAYEYYDAGNHWCKDCNTICGTMFDFFTHMHNKKHTQTLDPYNRPWASKTQNEAKQDAVKRTDKITVPAKGSEFLIPITGYYCQLCEEFLGDPISGEQHVKGYQHNEKYKKYVVENPLYEERRNLDRQAGLAVVLETERRRQSELKRKFSERPKEEKKEKQAKIMKEVKEDDRVSEELEDQLSEGRNSPEKAENRKRPSIKLQLKEEIKKEPPISSSFGKFSWKKPEKEEEKSLVIPSIPKEEIVESGKDKEDGKADPGKTKPIKIKLSGKTVVAHTSPWMPVVTTSTQTKIRPNLPIPSTVLRKSGSATVSKPAPLNTFLSIKSSGTTAKPLPVVKESSADLLLPPDIISKAFGGEEVILKGSPEEKMVLAEKNEPSHIPEQMLPPPPPPPPPPPPPPPVIPHPASPSPAQANAILAPVKSNPAVSHTVIPGFLGPNILNPVLPVAIMASAQPTAIPSDETAPGVSESDRDQTLFSVLVRPPPPLSSVFSEQAKKLEKRNSCLATANAKDLYDIFYSSGGKGAPETKLSGGPLANGENRAENSDASSTSTLNSSASQEELPSGRNLVSAPMVSSSEKPISKPLVSLGRLSAVENVDSKNRGSSYGFLQPLTRLCQNRPYETITPKTETLAKWASGSFQSDANKDVAPVRKIELDLGDPGPPGVEPASELSDTKCHTMQSQKLVETHLGESSKQQSQELHQPKDCGKSEVETSTELKEEGVKLSERTVREGTDINVGPNSIEDSNLNSGNRCMWEEEVEQPNLHRTDKKAKQSRKLITESKTQGKVVPELKTQTVSSTKAKIDSFPSEVRSLLQNPQDVKISAPELLLQSPYRSDMCLKDHEQKQGVPACSEEWLENSAPESASRTSRYRSLKLKRERSKDLQGKMTYKLTDWDENKNPETWESPEKPKAEALEPRDVHPELTVTIESKALENFEVTDLKVEELAALGSLGDIGVDFCNTRVDPAHRSPVALSQKVCEENSVSPLGGNPSSLTDFEPIPSFSEFPLDSPKTLVLNFGAEGEQNSSNPRTGRIAPNILKTGLPIENVGLGLGNLEGTHQALDLLAGGMMPEEIEETSKLEKQDSLRLESETINPLCLGPSPCLPDLVDFVTRTSGVQKEKICSPLSEPGDPPECSSLEMGLLQLEIPNASITEVAVPQVDEYSDNPLNVVKSVASGSHTRERVAGGSTIPQEIAAQEAAVDALQDHTESSVHS", "length": 2323, "header": "tr|F1MJN1-1|F1MJN1_BOVIN Isoform 1 of Zinc finger protein 318 OS=Bos taurus OX=9913 GN=ZNF318 PE=4 SV=4 CANONICAL=F1MJN1-1" }, "locus": { "chromosome": "23", "start_pos": 16955126, "end_pos": 16929150, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013481.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013481.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013481.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013481.7" } ] } }, { "isoform_ac": "F1MJN7-1", "url": "https://www.uniprot.org/uniprotkb/F1MJN7/entry", "sequence": { "sequence": "MYRSGARSSVSSHRPKESGGGDPRTGRSSGSSSGPARRTSPPSSCSSSSRTPARRPRSPSGHRGRRASPSPPRGRRASPSPPRGRRASPSPPRGRRGSPSPPRARRGSPSPPRGRRLFPPGSAGFRGSSRGESRADFARDGRGDHPGDSGSRSLRITVGNDHFCVGIPERRRLSDRLGSPVENLEDADRDDLTDDSVFTRSSQCSRGLERYISREEAPLSPFLGQLDEDYRARETFLHRSDYSPHISCHDDLLRGTERNRDKLKGSYSIRPEESSREAKRPRYDDTEKMHNMGSDHPSFTSGTRNYRQRRRSPSPRFLDPEFRELDLARRKREEEEERSRSLSQELVGVDSGGTSCPIPGLSGVLTASEPGYSLHRPEEVSVMPKKSILKKRIEVDMEPSLQLESFPSSTSSSQDHPLYSGHSSLPLSGAIAAFASEVENNKGTMVETTLKESQGNLYQWGPLPGIPKDNSPLREKFGSFLCHKEKLDMKAEGPERHTDFLLPHERASQDGSGFSCILSMLADSTSTQEKRRLSFPDIEDEEKFLYGDEEEDLKAESPPKPLGSSESEVMRQKASSLPSSAPTVKLESIEETNPEYAKIHDLLKTIGLDIGVAEISKLAARTQERLHGKKPSGSSADRRSSADRHFPADRCSSVDHRFSADRRSADPHRLESVEVHHSNTHSPEVSRPHQVSPVDPYLLTKNSPPFLKSDHPMGHIVGPEVVGSGFQSSVAVRCMLPSAPSAPVRLPHPASLSQFHVPRASQFAAARIPPNYQGPAIPPASFDAYRHYMAYAASRWPMYPASQPSNHPLPDSHRTVPVSKQATRSRPNLRVIPTVTPDEPKHEESVLGSIPTAQVPVHVSIPSLIRYNPEKISDEKNRASQKQKVIEEREKLKSDREARQKKMYYLRTELERLHKQQGEMLRKKRREKDGHKDPLLVEVSRLQDNIMKDIADLRQEAEEAEKKQSELDKVAQILGINISDKSQKSSSDSREPTEKTGKAEKSKSPEKVSSSSNSSSNCKESKVNSENSHTKSPKPAESPQPAKQSDQPVAAYEYYDAGNHWCKDCNTICGTMFDFFTHMHNKKHTQTLDPYNRPWASKTQNEAKQDAVKRTDKITVPAKGSEFLIPITGYYCQLCEEFLGDPISGEQHVKGYQHNEKYKKYVVENPLYEERRNLDRQAGLAVVLETERRRQSELKRKFSERPKEEKKEKQAKIMKEVKEDDRVSEELEDQLSEGRNSPEKAENRKRPSIKLQLKEEIKKEPPISSSFGKFSWKKPEKEEEKSLVIPSIPKEEIVESGKDKEDGKADPGKTKPIKIKLSGKTVVAHTSPWMPVVTTSTQTKIRPNLPIPSTVLRKSGSATVSKPAPLNTFLSIKSSGTTAKPLPVVKESSADLLLPPDIISKAFGGEEVILKGSPEEKMVLAEKNEPSHIPEQMLPPPPPPPPPPPPPPPVIPHPASPSPAQANAILAPVKSNPAVSHTVIPGFLGPNILNPVLPVAIMASAQPTAIPSDETAPGVSESDRDQTLFSVLVRPPPPLSSVFSEQAKKLEKRNSCLATANAKDLYDIFYSSGGKGAPETKLSGGPLANGENRAENSDASSTSTLNSSASQEELPSGRNLVSAPMVSSSEKPISKPLVSLGRLSAVENVDSKNRGSSYGFLQPLTRLCQNRPYETITPKTETLAKWASGSFQSDANKDVAPVRKIELDLGDPGPPGVEPASELSDTKCHTMQSQKLVETHLGESSKQQSQELHQPKDCGKSEVETSTELKEEGVKLSERTVREGTDINVGPNSIEDSNLNSGNRCMWEEEVEQPNLHRTDKKAKQSRKLITESKTQGKVVPELKTQTVSSTKAKIDSFPSEVRSLLQNPQDVKISAPELLLQSPYRSDMCLKDHEQKQGVPACSEEWLENSAPESASRTSRYRSLKLKRERSKDLQGKMTYKLTDWDENKNPETWESPEKPKAEALEPRDVHPELTVTIESKALENFEVTDLKVEELAALGSLGDIGVDFCNTRVDPAHRSPVALSQKVCEENSVSPLGGNPSSLTDFEPIPSFSEFPLDSPKTLVLNFGAEGEQNSSNPRTGRIAPNILKTGLPIENVGLGLGNLEGTHQALDLLAGGMMPEEIEETSKLEKQDSLRLESETINPLCLGPSPCLPDLVDFVTRTSGVQKEKICSPLSEPGDPPECSSLEMGLLQLEIPNASITEVAVPQVDEYSDNPLNVVKSVASGSHTRERVAGGSTIPQEIAAQEAAVDALQDHTESSVHS", "length": 2261, "header": "tr|F1MJN7-1|F1MJN7_BOVIN Computationally mapped isoform of Zinc finger protein 318 OS=Bos taurus OX=9913 GN=ZNF318 PE=4 SV=5 CANONICAL=F1MJN1-1" }, "locus": { "chromosome": "23", "start_pos": 16955126, "end_pos": 16929150, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000013479.7", "url": "https://www.ensembl.org/id/ENSBTAT00000013479.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000013479.7", "url": "https://www.ensembl.org/id/ENSBTAP00000013479.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:786496", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:786496", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "F1MJN1", "url": "https://www.uniprot.org/uniprotkb/F1MJN1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MJN1", "url": "https://www.uniprot.org/uniprotkb/F1MJN1" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "F1MJN1", "url": "https://www.uniprot.org/uniprotkb/F1MJN1" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "F1MJN1", "url": "https://www.uniprot.org/uniprotkb/F1MJN1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "F1MJN1", "url": "https://www.uniprot.org/uniprotkb/F1MJN1" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "F1MJN1", "url": "https://www.uniprot.org/uniprotkb/F1MJN1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1039, "end_pos": 1041, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1075, "end_pos": 1077, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1664, "end_pos": 1666, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2134, "end_pos": 2136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2258, "end_pos": 2260, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJN1" }, { "id": "SM00451", "database": "SMART", "url": "http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00451" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "U1-type", "eco_id": "ECO_0000259", "start_pos": 1119, "end_pos": 1153, "start_aa": "Ala", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1039, "end_pos": 1041 }, { "start_pos": 1075, "end_pos": 1077 }, { "start_pos": 1664, "end_pos": 1666 }, { "start_pos": 2134, "end_pos": 2136 }, { "start_pos": 2258, "end_pos": 2260 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region", "input_participant_list": [ "R-ALL-189075" ], "output_participant_list": [ "R-ALL-191103" ], "enzyme_list": [ "F1MJQ3-1", "F1MP21-1" ], "evidence": [ { "id": "R-BTA-188979", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-188979" } ] }, { "id": "R-BTA-191114", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region", "input_participant_list": [ "R-ALL-189071" ], "output_participant_list": [ "R-ALL-189108" ], "enzyme_list": [ "F1MJQ3-1", "F1MP21-1" ], "evidence": [ { "id": "R-BTA-191114", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-191114" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-189071", "participant_name": "starch (amylopectin) [extracellular region]", "crossref": [ { "id": "28057", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-189075", "participant_name": "starch (amylose) [extracellular region]", "crossref": [ { "id": "28102", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-189108", "participant_name": "limit dextrins [extracellular region]", "crossref": [ { "id": "28912", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-191103", "participant_name": "maltotriose 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"protein_name": "Transcription factor 7 like 1", "gene_name": "Tcf7l1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPQLGGGRGGGAGGGGGGSGAGATSGGDDLGANDELIPFQDEGGEEQEPSSDSASAQRDLDEVKSSLVNESENQSSSSDSEAERRPQPARDAFQKPRDYFAEVRRPQDGAFFKGPAYPGYPFLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAHLYGDPARWMVPPTFRSNKVPVLQHPHHLQHPLTPLITYSNDHFSPASPPTHLSPEIDPKTAGIPRPPHPSELSPYYPLSPGAVGQIPHPLGWLVPQQGQPMYSLPPGGFRHPYPALAMNASMSSLVSSRFSPHMVAPAHPGLPTSGIPHPAIVSPIVKQEPAPPSLSPAVSAKSPVTVKKEEEKKPHVKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRKWHNLSREEQAKYYELARKERQLHAQLYPTWSARDNYGKKKKRKREKQLSQTQSQQQIQEAEGALVSKSKKPCIQYLPPEKPCDSPASSHGSTLDSPATPSAALASPAAPAATHSEQAQPLSLTTKPETRAQLALHSAAFLSAKATASNSSQMGSQPPLLSRPLPLGSMPTALLTSPPSFPATLHAHQTLPVLQAQPLSLVTKSAH", "length": 602 }, "evidence": [ { "id": "F1MJS2", "url": "https://omabrowser.org/oma/group/F1MJS2/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9HCS4-1", "protein_name": "Transcription factor 7-like 1", "gene_name": "TCF7L1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPQLGGGGGGGGGGSGGGGGSSAGAAGGGDDLGANDELIPFQDEGGEEQEPSSDSASAQRDLDEVKSSLVNESENQSSSSDSEAERRPQPVRDTFQKPRDYFAEVRRPQDSAFFKGPPYPGYPFLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAHLSNKVPVVQHPHHMHPLTPLITYSNDHFSPGSPPTHLSPEIDPKTGIPRPPHPSELSPYYPLSPGAVGQIPHPLGWLVPQQGQPMYSLPPGGFRHPYPALAMNASMSSLVSSRFSPHMVAPAHPGLPTSGIPHPAIVSPIVKQEPAPPSLSPAVSVKSPVTVKKEEEKKPHVKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRKWHNLSREEQAKYYELARKERQLHSQLYPTWSARDNYGKKKKRKREKQLSQTQSQQQVQEAEGALASKSKKPCVQYLPPEKPCDSPASSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTKPETRAQLALHSAAFLSAKAAASSSGQMGSQPPLLSRPLPLGSMPTALLASPPSFPATLHAHQALPVLQAQPLSLVTKSAH", "length": 588 }, "evidence": [ { "id": "F1MJS2", "url": "https://omabrowser.org/oma/group/F1MJS2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9YHE8-1", "protein_name": "Transcription factor 7-like 1-A", "gene_name": "tcf7l1a", "tax_id": 7955, 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"evidence": [ { "database": "UniProtKB", "id": "F1MJS2", "url": "https://www.uniprot.org/uniprotkb/F1MJS2" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "F1MJS2", "url": "https://www.uniprot.org/uniprotkb/F1MJS2" } ], "pmid": "" }, { "name": "beta-catenin-TCF complex", "id": "GO:1990907", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990907", "evidence": [ { "database": "UniProtKB", "id": "F1MJS2", "url": "https://www.uniprot.org/uniprotkb/F1MJS2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "DNA-templated transcription", "id": "GO:0006351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006351", "evidence": [ { "database": "UniProtKB", "id": "F1MJS2", "url": "https://www.uniprot.org/uniprotkb/F1MJS2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MJS2", "url": "https://www.uniprot.org/uniprotkb/F1MJS2" } ], "pmid": "" }, { "name": "canonical Wnt signaling pathway", "id": "GO:0060070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060070", "evidence": [ { "database": "UniProtKB", "id": "F1MJS2", "url": "https://www.uniprot.org/uniprotkb/F1MJS2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1MJS2", "url": "https://www.uniprot.org/uniprotkb/F1MJS2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1MJS2", "url": "https://www.uniprot.org/uniprotkb/F1MJS2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 387, "end_pos": 389, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJS2-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 590, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJS2-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJS2" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS2" }, { "id": "PS50118", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50118" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "HMG box", "eco_id": "ECO_0000259", "start_pos": 347, "end_pos": 415, "start_aa": "Val", "end_aa": "Ser", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 483 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 278, "end_pos": 280 }, { "start_pos": 387, "end_pos": 389 }, { "start_pos": 72, "end_pos": 74 }, { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MJS7-1", "uniprot_ac": "F1MJS7", "uniprot_id": "F1MJS7_BOVIN", "mass": { "chemical_mass": 88264.0, "monoisotopic_mass": 88264.0 }, "refseq": { "ac": "XP_005224463", "name": "GATOR2 complex protein WDR24 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224463" }, "gene_names": [ { "name": "WDR24", "type": "recommended", "evidence": [ { "id": "F1MJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ] }, { "name": "WDR24", "type": "synonym", "evidence": [ { "id": "XP_005224463", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224463" } ] } ], "protein_names": [ { "name": "GATOR2 complex protein WDR24", "type": "recommended", "evidence": [ { "id": "F1MJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS7/entry#names_and_taxonomy" } ] }, { "name": "2.3.2.27", "type": "synonym", "evidence": [ { "id": "F1MJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS7/entry#names_and_taxonomy" } ] }, { "name": "GATOR2 complex protein WDR24 isoform X1", "type": "synonym", "evidence": [ { "id": "XP_005224463", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224463" } ] }, { "name": "WD repeat-containing protein 24", "type": "synonym", "evidence": [ { "id": "F1MJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. In addition to its role in regulation of the mTORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux. Within the GATOR2 complex, WDR24 constitutes the catalytic subunit that mediates 'Lys-6'-linked ubiquitination of NPRL2.", "evidence": [ { "database": "UniProtKB", "id": "F1MJS7", "url": "https://www.uniprot.org/uniprotkb/F1MJS7#function" }, { "database": "UniProtKB", "id": "ARBA00046230", "url": "https://www.uniprot.org/uniprotkb/ARBA00046230#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MJS7", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "WDR24", "url": "https://www.uniprot.org/uniprotkb/F1MJS7", "locus": { "chromosome": "25", "start_pos": 588615, "end_pos": 593763, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019006", "url": "https://www.ensembl.org/id/ENSBTAG00000019006" } ] } } ], "crossref": [ { "id": "F1MJS7", "url": "https://alphafold.ebi.ac.uk/entry/F1MJS7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019006", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019006", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16693", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16693", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "507528", "url": "https://www.ncbi.nlm.nih.gov/gene/507528", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056551", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056551", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "EPMWLIS", "url": "https://omabrowser.org/oma/group/EPMWLIS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MJS7", "url": "https://www.orthodb.org/?gene=F1MJS7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46200", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46200", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46200:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46200:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF23098", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23098", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-9639288", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9639288", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_005224463", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224463", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MJS7", "url": "https://www.uniprot.org/uniprotkb/F1MJS7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJS7-1", "url": "https://www.uniprot.org/uniprotkb/F1MJS7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEKMSRVTTALGGSVLTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMATHRAKEVHCVQTIASVARVKWRPECRHHLATCSMMVDHNVYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSTLCQHLFRDASQPVERANPEGLCYGLFGDLAFAAKESLVATESGRKPYAGDRRHPIFFKRKLDPAEPFAGLASSALNVFEIEPGSGSMSWFVDTAERYALAGRPLAELCDHNAKVARELGRNQVAQTWTMLRIIYCSPGLVPTTNLNHSMGKGSSCGLPLMNSFNLKDMAPGLGSETRLDRSKGDTRSDTVLLDSSATLITNEDNEETEGSDVPTDYLLGDVEGEDDELYLLDPEHAHSEEPEYVLPQEAFPLRHEIVDTPPGPEHLQDKADSPHVSGSEADAASLVPVDSSFSLISVSHALCDSRLPPDFFSALVCDMLRFYAEQGDVQMAVSVLIVLGERVRKDIDEQTQEHWYTSYIDLLQRFCLWNVSNQVVKLSTSRAISCLNQASTTLHVNCSHCKRPMSSRGWVCDRCRRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLCEYS", "length": 790, "header": "tr|F1MJS7-1|F1MJS7_BOVIN Isoform 1 of GATOR2 complex protein WDR24 OS=Bos taurus OX=9913 GN=WDR24 PE=3 SV=1 CANONICAL=F1MJS7-1" }, "isoforms": [ { "isoform_ac": "F1MJS7-1", "url": "https://www.uniprot.org/uniprotkb/F1MJS7/entry", "sequence": { "sequence": "MEKMSRVTTALGGSVLTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMATHRAKEVHCVQTIASVARVKWRPECRHHLATCSMMVDHNVYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSTLCQHLFRDASQPVERANPEGLCYGLFGDLAFAAKESLVATESGRKPYAGDRRHPIFFKRKLDPAEPFAGLASSALNVFEIEPGSGSMSWFVDTAERYALAGRPLAELCDHNAKVARELGRNQVAQTWTMLRIIYCSPGLVPTTNLNHSMGKGSSCGLPLMNSFNLKDMAPGLGSETRLDRSKGDTRSDTVLLDSSATLITNEDNEETEGSDVPTDYLLGDVEGEDDELYLLDPEHAHSEEPEYVLPQEAFPLRHEIVDTPPGPEHLQDKADSPHVSGSEADAASLVPVDSSFSLISVSHALCDSRLPPDFFSALVCDMLRFYAEQGDVQMAVSVLIVLGERVRKDIDEQTQEHWYTSYIDLLQRFCLWNVSNQVVKLSTSRAISCLNQASTTLHVNCSHCKRPMSSRGWVCDRCRRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLCEYS", "length": 790, "header": "tr|F1MJS7-1|F1MJS7_BOVIN Isoform 1 of GATOR2 complex protein WDR24 OS=Bos taurus OX=9913 GN=WDR24 PE=3 SV=1 CANONICAL=F1MJS7-1" }, "locus": { "chromosome": "25", "start_pos": 593271, "end_pos": 588680, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000025300.5", "url": "https://www.ensembl.org/id/ENSBTAT00000025300.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000025300.3", "url": "https://www.ensembl.org/id/ENSBTAP00000025300.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-BTA-9639288", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9639288", "resource": "Reactome", "description": "Amino acids regulate mTORC1" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A3Q2U8E6-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "WDR24", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEKMARVSTALGGNTLTGRTMFCHLDAPANAISVCRDAAQVVVAGRNIFKIYSIEEEQFVEKLNLRVGRKPSLNFSCADVVWHQMDENLLATAATNGVVVTWNLGKPSRNKQDQLFTEHKRTVNKVCFHPTEVYMLLSGSQDGYMKCFDLRKKDSVSTFSGQSESVRDVQFSIRDYFTFAATFENGNVQLWDIRRPDRYERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMNTTRAKEIYCVQTIASVARVKWRPECKHHIATCSMMVDHNIYVWDVRRPFIPSAMFEEHKDVTTGIVWRHLHDPYFLLSGSKDSTLYQHIFKDASQPIDRANPEGLCYSLYGDLAFAAKESLISSDSNRKPYIGDRRHPIFFKRKLDPTEQFEYISSSSALSVFETDVESGSMDWFVHTAKQYALAGRPLAELCDHNAKVAKGLDRNQVAQTWTMLRIIYSSLGTVSSTNLNHSMGKGSTTLPLMNSFNLKDIPSGLGSESRLDRSKGESRTENILMDSSSTLINNEDNEETEGSDVPADYLLGDVEADEDDLYMMDHENPHAEEQEYSLPQEAFPLRHEIVDNPSALDHLQDKADSPHVSGNEAETVSLTPVESFSLISISHSLYENRLPSDFFNPIVRDTLLFYAEQGDVQTAVSVLIVLGDRIRKEIDEQTQEHWYTSYIDLLQRFQLWNISNEVIKLSTCRAINCLNQASTTLHINCSNCKRPMSNRGWICDRCRQCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLETSSHCPAGCGHLCEYT", "length": 789 }, "evidence": [ { "id": "F1MJS7", "url": "https://omabrowser.org/oma/group/F1MJS7/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1RG37-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "WDR24", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MEKMSRVTTALSGSALTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEVHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSTLCQHLFRDASQPVERANPEGLCYGLFGDLAFAAKESLVAVESGRKPYTGDRRHPIFFKKKVDPAAPFAGLASSALSVFEMEPGSGSMSWFVDTAERYALAGRPLAELCEHNAKVARELGRNQVAQTWTMLRIIYCSPGLVPGTNLNHSVGKGSSCGLPLMNSFNLKDMAPGLGSETRLDRSKGDTRSDTVLLDSSATLITNEDNEETEGSDVPADYLLCDVEGEDDELYLLDPEHTHSEEPEYVLPQEAFPLRHEIVDTPPGPEHLQDKADSPHVSGSEADVASLVPMDSSFSLISVSHALYDSRLPPAFFSALVCDMLHFYAEQGDVQMAVSVLVVLGERVRKDIDEQTQEHWYTSYIDLLQRFCLWNVSNQVVKLSTSRAISCLNQASTTLHVNCSHCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLCEYS", "length": 790 }, "evidence": [ { "id": "F1MJS7", "url": "https://omabrowser.org/oma/group/F1MJS7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3HBU4-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "Wdr24", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MEKMSRVTTALSGSALTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSTLCQHLFRDASQPVERANPEGLCYGLFGDLAFAAKESLVAAESGRKPYMGDRRHPIFFKRKLDPAEPFSGLASSALSVFETESGGGSMSWFVDTAERYALAGRPLAELCDHNAKVARELGRNQVAQTWTMLRIIYCSPGLVSSANLNHSVGKGSSCGLPLMNSFNLKDMGPGLGSETRLDRSKGDTRSDTALLDSSATLITNEDNEETEGSDVPADYLLGDVEGEEDELYPLDTEHVHPEEPEYVLPQEAFPLRHEIVDTPSGPEHLQDKADSPHVSGNEADTASLAPVDSSSSLLSVSHALYDSRLPPDFFSVLVRDMLHFYAEQGDVQMAVSVLIVLGERVRKDIDEQTQEHWYTSYIDLLQRFCLWNVSNEVVKLSTSRAVSCLNQASTTLHVNCSHCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLCEYS", "length": 790 }, "evidence": [ { "id": "F1MJS7", "url": "https://omabrowser.org/oma/group/F1MJS7/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3V8L0-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "Wdr24", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEKMSRVTTALSGSALTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEIHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSTLCQHLFRDASQPVERANPEGLCYGLFGDLAFAVKESLVAAESGRKPYAGDRRHPIFFKRKLDPAEPFSGLASSALSVFETESGGGSMSWFVDTAERYALAGRPLAELCDHNAKVARELGRNQVAQTWTMLRIIYCSPGLVSSANLNHSVGKGSSCSLPLMNSFNLKDMGPGLGSETRLDRSKGDTRSDTVLLDSSATLITNEDNEETEGSDVPADYLLGDVEGEEDELYPLDTEHVHPEEPEYVLPQEAFPLRHEIVDTPSGPEHLQDKADSPHVSGNEADTASLAPVDSSSSLLSVSHALYDSRLPPDFFSVLVRDMLHFYAEQGDVQMAVSVLIVLGERVRKDIDEQTQEHWYTSYIDLLQRFCLWNVSNEVVKLSTSRAVSCLNQASTTLHVNCSHCKRPMSSRGWVCDRCRRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLCEYS", "length": 790 }, "evidence": [ { "id": "F1MJS7", "url": "https://omabrowser.org/oma/group/F1MJS7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q54JS5-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "wdr24", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MNQMNQPPNKCQTYLNLGSPLSAISSSPDSTKLIVAGRDIVKIVSVQNNEFKVTSNLRAGKTQSLNYTGNDCCWHPSLLENYRFLIATAATNGAVVIWNTVREGSKSVERVFTDHSRAVNKLAWHPEKLDCILTGSQDNTLRMWDIRDSANASKITFSPKSESIRDVQFNPSQANQFAAAFDNGTIQLWDIRKPTIAVEKITSHQGLVLTIDWHPEEKNIIASGGRDRAIRVWDFSNGKSLNNVSTISSVSRIKWRPGNKWHIASCSSIVDFQIHIWDVKKPYIPLFSFTDHRDVPTGLIWKSPSSLISCSKDSHLLLNEFQDSYKPYQHIRTTGITWNVNNELASINDKINRTQSNESLPSLSTQFPSFFASFNVPTPPPLPPLVKVEQGIMNIYTPKYQNSEIVYDEKYLFEHFAKNYRFRGESFNQLCDHNQFVSQSVNQHHISTMWSLLKLHYSNLDEIQQHKELIEQQQKEELEKLNNKKIEKQQPQKLKKQQQQQQQQQQQQQQQSQQQLQQPQLQQPQQQQQLQQPQQQLRQQNDKNIKEQQIQYIENLENKQLDSKNIIDNSNDSNQEININKEDKEDEEEDDDNTSNNLDDNQMGDIFDPSNDMMTAKEPPSSSLMEFNANDTGNDQFCNILSAEAVTPLVSLPTSISLERQKSTDNISDNNSNVHVNIKRQNQPTNNNNNNSNIDNLEKKSNKSKSTKENKESSLTDQNKQKRNDNKEKIDNNEIDNDNKDNNDDDDNDVDNIGEDNDEINNNNDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNNNNDNNNNNNINNKKNKIKNKSIENKKDILDKKEINDEDNKSNDENDSLKILIPCFEFEEFNFQPIITDMLEACIEKGDVQTCVFIVLILGRYMDLNIEKHRLTTWFGSYIELLQRYKMWSLALEVMKYCDDQIINQASKRHTTLISACSSCGKSIPQNSIICEKCNKASSKCSICRLPVKGMWVWCQGCGHGGHLEHMKSWFIDKNQKSCPTGCTHICTPFKK", "length": 1023 }, "evidence": [ { "id": "F1MJS7", "url": "https://omabrowser.org/oma/group/F1MJS7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q8CFJ9-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "Wdr24", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEKMSRVSTALSGSALTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEIHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSTLCQHLFRDASQPVERANPEGLCYGLFGDLAFAVKESLVAAESGRKPYAGDRRHPIFFKRKLDPAEPFSGLASSALSVFETESSGGSMSWFVDTAERYVLAGRPLAELCDHNAKVARELGRNQVAQTWTMLRIIYCSPGLVSSANLNHSVGKGSSCGLPLMNSFNLKDMGPGLGSETRLDRSKGDTRSDAALLDSSATLVTNEDNEETEGSDVPADYLLGDVEGEDDELYPLDTEHVHSEEPEYVLPQEAFPLRHEIVDTPSGPEHLQDKADSPHVSGNEADTASLAPVDSSSSLLSVSHALYDSRLPPDFFSVLVRDMLRFYAEQGDVQMAVSVLIVLGERVRKDIDEQTQEHWYTSYIDLLQRFCLWNVSNEVVKLSTSRAVSCLNQASTTLHVNCSHCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLCEYS", "length": 790 }, "evidence": [ { "id": "F1MJS7", "url": "https://omabrowser.org/oma/group/F1MJS7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96S15-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "WDR24", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEKMSRVTTALGGSVLTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSLCQHLFRDASQPVERANPEGLCYGLFGDLAFAAKESLVAAESGRKPYTGDRRHPIFFKRKLDPAEPFAGLASSALSVFETEPGGGGMRWFVDTAERYALAGRPLAELCDHNAKVARELGRNQVAQTWTMLRIIYCSPGLVPTANLNHSVGKGGSCGLPLMNSFNLKDMAPGLGSETRLDRSKGDARSDTVLLDSSATLITNEDNEETEGSDVPADYLLGDVEGEEDELYLLDPEHAHPEDPECVLPQEAFPLRHEIVDTPPGPEHLQDKADSPHVSGSEADVASLAPVDSSFSLLSVSHALYDSRLPPDFFGVLVRDMLHFYAEQGDVQMAVSVLIVLGERVRKDIDEQTQEHWYTSYIDLLQRFRLWNVSNEVVKLSTSRAVSCLNQASTTLHVNCSHCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLCEYS", "length": 790 }, "evidence": [ { "id": "F1MJS7", "url": "https://omabrowser.org/oma/group/F1MJS7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9XZ25-1", "protein_name": "GATOR2 complex protein Wdr24", "gene_name": "Wdr24", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPDSVEDTSTISLRICLEGHANALALNKDNNQIALAGRSLLKVYSINSNGFTESCNMRGKNQNLSYSANDVAWSTLDSNLLATAATNGVVSVWDLSKFGRQKQLLVYNEHERTAHTVTFHSSEPNILISGSQDGTIKCFDIRSDKSINTYFCNSESVRDVKFSPHTQNIFSAVSENGTVQLWDMRKWDKCMVQFTAHYGPVYTCDWHPTRNWLATGSRDKQIKVWNMDGRPGLEHTIHTIAVVGRVKWRPERTYHIASCALVVDYSVHVWDIRRPYIPFASFNEHTNVTTGIAWQGSDSHCLLSISKDSTIYKHAFKDATRPALKANAQGASLGRFGDISFANKIKEYEPKTSGASNTKSSSFIRRKTNVAGSIQFHLDHSKMYKFMVNDTFSGYPLSESVSRPTQEHESFIGCARELVISGKKLSELCEHNAEVSKKYGKHNATTLWNFIKLFYGSNHFEPPFEHRSSFSNQKNPMNSRRATQVASDWPQQRTELGQDLNGNTPETAHEIDVANVDDDTLGSSGVEHPPTSSVILSETQIISEITFDNFELLRNGFIYVGPTECPKALAFPALHHDVQAARPQLDLKASDHEKSPPPHVPTVLKVSHVPPIPMWEPHKFVSDALMLMNDVGDVQTALTVLIALGEARKLLPIDDALVEHWFYTYVDQLHRYELWNEACEVINRSWLRSVQQLNQHSTAMHTNCGECGRPMGGKVGWYCDKCKSMQSAKCCVCGLIVRGVYAWCQGCSHGGHIEHLQKYFAKHSKCPKCGHLCAYS", "length": 776 }, "evidence": [ { "id": "F1MJS7", "url": "https://omabrowser.org/oma/group/F1MJS7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of TORC1 signaling", "id": "GO:1904263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904263", "evidence": [ { "database": "UniProtKB", "id": "F1MJS7", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "F1MJS7", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ], "pmid": "" }, { "name": "positive regulation of macroautophagy", "id": "GO:0016239", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016239", "evidence": [ { "database": "UniProtKB", "id": "F1MJS7", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ], "pmid": "" }, { "name": "cellular response to amino acid starvation", "id": "GO:0034198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034198", "evidence": [ { "database": "UniProtKB", "id": "F1MJS7", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ], "pmid": "" }, { "name": "protein K6-linked ubiquitination", "id": "GO:0085020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0085020", "evidence": [ { "database": "UniProtKB", "id": "F1MJS7", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "F1MJS7", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "F1MJS7", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ], "pmid": "" }, { "name": "vacuolar membrane", "id": "GO:0005774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005774", "evidence": [ { "database": "UniProtKB", "id": "F1MJS7", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ], "pmid": "" }, { "name": "GATOR2 complex", "id": "GO:0061700", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061700", "evidence": [ { "database": "UniProtKB", "id": "F1MJS7", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "F1MJS7", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "F1MJS7", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 468, "end_pos": 470, "annotation": "n_glycosylation_sequon" }, { "start_pos": 691, "end_pos": 693, "annotation": "n_glycosylation_sequon" }, { "start_pos": 718, "end_pos": 720, "annotation": "n_glycosylation_sequon" }, { "start_pos": 74, "end_pos": 76, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-BTA-9639287", "name": "SESN1,2 binds L-leucine and dissociates from GATOR2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q58CN8-1", "F1MJS7-1" ], "evidence": [ { "id": "R-BTA-9639287", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9639287" } ] }, { "id": "R-BTA-9640195", "name": "RRAGA,B hydrolyzes GTP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P31404-1", "Q58CN8-1", "Q3SX43-1", "E1B7X8-1", "F1MJS7-1", "A0A3Q1MEZ6-1" ], "evidence": [ { "id": "R-BTA-9640195", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9640195" } ] }, { "id": "R-BTA-9640237", "name": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJS7-1" ], "evidence": [ { "id": "R-BTA-9640237", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9640237" } ] }, { "id": "R-BTA-9657619", "name": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1MJS7-1" ], "evidence": [ { "id": "R-BTA-9657619", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9657619" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1MEZ6", "gene_name": "MTOR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MEZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MEZ6" } ] } ] }, { "uniprot_ac": "E1B7X8", "gene_name": "BMT2", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "E1B7X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7X8" } ] } ] }, { "uniprot_ac": "F1MJS7", "gene_name": "WDR24", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1MJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1MJS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJS7" } ] } ] }, { "uniprot_ac": "P31404", "gene_name": "ATP6V1A", "activity": [ { "ec_number": "7.1.2.2", "activity": "ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out).", "evidence": [ { "id": "P31404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P31404" } ] }, { "ec_number": "7.1.2.2", "activity": "", "evidence": [ { "id": "P31404", 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"categories": [ "Protein Classification" ] }, { "id": "F1MJT5", "url": "https://www.orthodb.org/?gene=F1MJT5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24388", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24388", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24388:SF56", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24388:SF56", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13836", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13836", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001071403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071403", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MJT5", "url": "https://www.uniprot.org/uniprotkb/F1MJT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJT5-1", "url": "https://www.uniprot.org/uniprotkb/F1MJT5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEPPCMLCEEDQEPEPQKSVGETKQVDDEDAELIFVGVEHVNEDADLIFVGMTSNSKPVVSNILNRVTPGSCSRRKRYGHFRKDNAHKLQPVSHVTRTSEAKIVLPVSDSESRSTDSPIIIEPLSKPDYKNISPQIVPNSFSELCSPLITFTSSLQHPVETTVSAGDMNKSPRVSKRLSTSETNSTNPKRPKLSDGIIGEHSLALSPSGIFQQNFLTTQQSKPDSVHTSLSHVQNGEPCPTAFAKDNVHCKPVSPLGENGLTKSDFPSLASQKKIVDPTEGNLIVLLRDFYYGQHIGDGQPEPKTHTAFKCLSCLKVLKNLKFMNHMKHHLELERQRGDSWKNHTTCQHCHRQFPTPFQLQCHIESVHTSQEPSTVCKICELSFETDQVLLQHMKDNHKPGEMPYVCQVCSYRSSVFADVDAHFRAYHGNTKNLLCPFCLKIFKTATPYMCHYRGHWEKSFHQCSKCRLQFLTFKEKMEHKTQCHQMFKKPKQLEGLPPETKVVIQVSLEPLQPGLVEVASITVNISDSEPSPPKSKSRSSKKPC", "length": 545, "header": "tr|F1MJT5-1|F1MJT5_BOVIN Isoform 1 of Zinc finger protein 280B OS=Bos taurus OX=9913 GN=ZNF280B PE=4 SV=2 CANONICAL=F1MJT5-1" }, "isoforms": [ { "isoform_ac": "F1MJT5-1", "url": "https://www.uniprot.org/uniprotkb/F1MJT5/entry", "sequence": { "sequence": "MEPPCMLCEEDQEPEPQKSVGETKQVDDEDAELIFVGVEHVNEDADLIFVGMTSNSKPVVSNILNRVTPGSCSRRKRYGHFRKDNAHKLQPVSHVTRTSEAKIVLPVSDSESRSTDSPIIIEPLSKPDYKNISPQIVPNSFSELCSPLITFTSSLQHPVETTVSAGDMNKSPRVSKRLSTSETNSTNPKRPKLSDGIIGEHSLALSPSGIFQQNFLTTQQSKPDSVHTSLSHVQNGEPCPTAFAKDNVHCKPVSPLGENGLTKSDFPSLASQKKIVDPTEGNLIVLLRDFYYGQHIGDGQPEPKTHTAFKCLSCLKVLKNLKFMNHMKHHLELERQRGDSWKNHTTCQHCHRQFPTPFQLQCHIESVHTSQEPSTVCKICELSFETDQVLLQHMKDNHKPGEMPYVCQVCSYRSSVFADVDAHFRAYHGNTKNLLCPFCLKIFKTATPYMCHYRGHWEKSFHQCSKCRLQFLTFKEKMEHKTQCHQMFKKPKQLEGLPPETKVVIQVSLEPLQPGLVEVASITVNISDSEPSPPKSKSRSSKKPC", "length": 545, "header": "tr|F1MJT5-1|F1MJT5_BOVIN Isoform 1 of Zinc finger protein 280B OS=Bos taurus OX=9913 GN=ZNF280B PE=4 SV=2 CANONICAL=F1MJT5-1" }, "locus": { "chromosome": "17", "start_pos": 70984132, "end_pos": 70982498, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000001332.5", "url": "https://www.ensembl.org/id/ENSBTAT00000001332.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000001332.4", 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"MPGLRRDRLLTLLLLGALLSADLYFHLWPQVQRQLRPRERPPGCPCAGRAASPAPAPAAAPSAPRPAAHNFSRARPRTEQDRGGRSVPRSKLRALFAHPLYNVPEEPPLLGPEDSLLASQEALRYYRRKVARWNRRHKIYKEQLNLTSLDPPVQFRLEASWVQFHLGINRHGLYSRSSPVVSKLLHDMRHFPTISADYSQDEKALLGACDCTQIVKPSGVHLKLVLRFSDFGKAMFKPMRQQRDEETPEDFFYFIDFQRHNAEIAAFHLDRILDFRRVPPTVGRLVNVTKEILEVTKNEILQSVFFVSPASNVCFFAKCPYMCKTEYAVCGNPHLLEGSLSAFLPSLNLAPRLSVPNPWIRSYSLAGKEEWEVNPLYCDTVKQVYPHNSSNRLLNIIDMAIFDFLTGNMDRHHYEMFTKFGDDGFLIHLDNARGFGRHSQDEISILSPLSQCCRIKRKTLLHLQLLAQADYRLSDVMRESLLEDQLTPVLTEPHLLALDRRLQTILRTVERCVEAHGEQSVVAGGPEEQPAPDSGRANLAS", "length": 541 }, "evidence": [ { "id": "F1MJW4", "url": "https://omabrowser.org/oma/group/F1MJW4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "I7LRF5-1", "protein_name": "FAM20A, golgi associated secretory pathway pseudokinase", "gene_name": "Fam20a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:781036", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781036", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AAYWERK", "url": "https://omabrowser.org/oma/group/AAYWERK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MJX8", "url": "https://www.orthodb.org/?gene=F1MJX8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44653", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44653", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44653:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44653:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00226", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00226", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23082", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23082", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024856724", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024856724", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MJX8", "url": "https://www.uniprot.org/uniprotkb/F1MJX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MJX8-1", "url": "https://www.uniprot.org/uniprotkb/F1MJX8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTAPCSRPARLPPRRRPGLVPFPPPLLLLLLLAAAGPAHGWESGDLELFDLVEEVQLNFYQFLGVQQDASSADIRKAYRKLSLTLHPDKNKDENAETQFRQLVAIYEVLKDDERRQRYDDILINGLPDWRQPVFYYRRVRKMSNAELALLLFIILTVGHYAVVWSIYLEKQLDELLSRKKREKKKKTGGKTVDVSKLGASEKNERLLVKPQWHDLLPCKLGIWFCLTLKALPHLIQDAGQFYAKYKETRLKEKEDELTRAELETLQKQKKVKIKKPKPEFPVYTPLESTYIQSYDHGTSIEEIEEQMDDWLENRNRTQKKQAPEWTEEDLSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRLSELKSTAQNPRPTRPTAALQDSIITQREEAQSATEEEEEEAAELGAEAAEESRPRRRRPARPLEPEERVRGKRQKDFDLSEQRESSDEESQQRERPRASEEPWTQNQQKLLELALQQYPRGSSDRWDKIAKCVPSKSKEDCIARYKLLVELVQKKKQARS", "length": 542, "header": "tr|F1MJX8-1|F1MJX8_BOVIN Isoform 1 of DnaJ homolog subfamily C member 1 OS=Bos taurus OX=9913 GN=DNAJC1 PE=4 SV=3 CANONICAL=F1MJX8-1" }, "isoforms": [ { "isoform_ac": "F1MJX8-1", "url": "https://www.uniprot.org/uniprotkb/F1MJX8/entry", "sequence": { "sequence": "MTAPCSRPARLPPRRRPGLVPFPPPLLLLLLLAAAGPAHGWESGDLELFDLVEEVQLNFYQFLGVQQDASSADIRKAYRKLSLTLHPDKNKDENAETQFRQLVAIYEVLKDDERRQRYDDILINGLPDWRQPVFYYRRVRKMSNAELALLLFIILTVGHYAVVWSIYLEKQLDELLSRKKREKKKKTGGKTVDVSKLGASEKNERLLVKPQWHDLLPCKLGIWFCLTLKALPHLIQDAGQFYAKYKETRLKEKEDELTRAELETLQKQKKVKIKKPKPEFPVYTPLESTYIQSYDHGTSIEEIEEQMDDWLENRNRTQKKQAPEWTEEDLSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRLSELKSTAQNPRPTRPTAALQDSIITQREEAQSATEEEEEEAAELGAEAAEESRPRRRRPARPLEPEERVRGKRQKDFDLSEQRESSDEESQQRERPRASEEPWTQNQQKLLELALQQYPRGSSDRWDKIAKCVPSKSKEDCIARYKLLVELVQKKKQARS", "length": 542, "header": "tr|F1MJX8-1|F1MJX8_BOVIN Isoform 1 of DnaJ homolog subfamily C member 1 OS=Bos taurus OX=9913 GN=DNAJC1 PE=4 SV=3 CANONICAL=F1MJX8-1" }, "locus": { "chromosome": "13", "start_pos": 23148498, "end_pos": 22968823, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000047358.5", "url": "https://www.ensembl.org/id/ENSBTAT00000047358.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000044570.4", "url": "https://www.ensembl.org/id/ENSBTAP00000044570.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 344, "start_aa": "Thr", "end_pos": 344, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr344", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:781036", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:781036", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1LVX1-1", "protein_name": "DnaJ homolog subfamily C member 1", "gene_name": "Dnajc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAWLRTALSESSNMWVPGFGPARLPRRPGLVSSSMRPLWPLLLFLLVAVRPVRAWESGDLELFDLVEEVQLNFYEFLGVQQDASSADIRKAYRKLSLTLHPDKNKDENAETQFRQLVAIYEVLKDDERRQRYDDILINGLPDWRQPVFYYRRVRKMSNAELALLLFIILTVGHYAVVWSIYLEKQLDELLSRKKREKKRKTGSKSVDAAKPGASERNERLLIKPQWHDLLPCKLGIWFCLTLKALPHLIQDAGQFYAKYKETKLKEKEDALARVELETLHKQKKAKVKKPKPEFPVYTPLENTYIQSYDHGTSIEEIEEQMDDWLENRNRTQKKQAPEWTEEDLSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKELKDSVTSSPGMTRLSELKSNVQNSRPLKIATALPDDIITQREDSAGAIEEEEEEQETAEGDQETVTSEARPRRRKSAKVAEVVTRVEPEEKLRGKRQKDFDISEQNDSSDEERPRKERSRAAEDAWTQSQQKLLELALQQYPKGASDRWDKIAKCVPSKSKEDCIARYKLLVELVQKKKQAKS", "length": 565 }, "evidence": [ { "id": "F1MJX8", "url": "https://omabrowser.org/oma/group/F1MJX8/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "I3L6W6-1", "protein_name": "DnaJ homolog subfamily C member 1", "gene_name": "DNAJC1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTAPCSRLARLPPRRRLRLLPFPPPLLLLLLAAAGPARGWESGDLELFDLVEEVQLNFYQFLGVQQDASSADIRKAYRKLSLTLHPDKNKEENAETQFRQLVAIYEVLKDDERRQRYDDILINGLPDWRQPVYYYRRVRKMSNAELALLLFIILTVGHYAVVWSIYLEKQLDELLSRKKREKKKKTGGKTVDVSKLGASEKNERLLLKPQWHDLLPCKLGIWFCLTLKALPHLIQDAGQFYAKYKETKLKEKEDALTRAELETLQKEKKVKVKKPKPEFPVYTPLESAYIQSYDHGTSIEEIEEQMDDWLENRNRTQKKQAPEWTEEDLSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRLSDLRPTAQNPRPPKSTAALPDDLITQREEPAAEEAEEQGEAEEQEAEVPESRPRRRRPARLPEPEEKVRAKRQKDFDLSEQMESSDEESQRRERTRATEEPWTQNQQKLLELALQQYPKGSSERWDKIAKCVPSKTKEDCIARYKLLVELVQKKKQAKS", "length": 540 }, "evidence": [ { "id": "F1MJX8", "url": "https://omabrowser.org/oma/group/F1MJX8/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q61712-1", "protein_name": "DnaJ homolog subfamily C member 1", "gene_name": "Dnajc1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MWVPGFGSARLPQRRRSGLESSSVRPLWLLLLFLLAAVRPVRAWESGDLELFDLVEEVQLNFYEFLGVQQDASSADIRKAYRKLSLTLHPDKNKDENAETQFRQLVAIYEVLKDDERRQRYDDVLINGLPDWRQPVFYYRRVRKMSNAELALLLFIILTVGHYAVVWSIYLEKQLDELLGRKKRERKKKTGSKSVDAAKLGASEKNERLLIKPQWHDLLPCKLGIWFCLTLKALPHLIQDAGQFYAKYKETKLKEKEDALARIEIETLQKQKKVKVKKPKPEFPVYMPLENTYIQSYDHGTSIEEIEEQMDDWLENRKRTQKRQAPEWTEEDLSQLTRSMVKFPGGTPGRWDKIAHELGRSVTDVTTKAKELKDSVTSSPGMTRLSELKSNGQNSRPIKIATALPDDIITQREDSAGAMEDEEHEAAEGEQESATTEARPRRRKSARAAEAVTRVEPEEKLRGKRQKDFDISEQNDSSDEEKQRKERTRAAEEAWTQSQQKLLELALQQYPKGASDRWDKIAKCVPSKSKEDCIARYKLLVELVQKKKQAKS", "length": 552 }, "evidence": [ { "id": "F1MJX8", "url": "https://omabrowser.org/oma/group/F1MJX8/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96KC8-1", "protein_name": "DnaJ homolog subfamily C member 1", "gene_name": "DNAJC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTAPCSQPAQLPGRRQLGLVPFPPPPPRTPLLWLLLLLLAAVAPARGWESGDLELFDLVEEVQLNFYQFLGVQQDASSADIRKAYRKLSLTLHPDKNKDENAETQFRQLVAIYEVLKDDERRQRYDDILINGLPDWRQPVFYYRRVRKMSNAELALLLFIILTVGHYAVVWSIYLEKQLDELLSRKKREKKKKTGSKSVDVSKLGASEKNERLLMKPQWHDLLPCKLGIWFCLTLKALPHLIQDAGQFYAKYKETRLKEKEDALTRTELETLQKQKKVKKPKPEFPVYTPLETTYIQSYDHGTSIEEIEEQMDDWLENRNRTQKKQAPEWTEEDLSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRLSELKSTVQNSRPIKTATTLPDDMITQREDAEGVAAEEEQEGDSGEQETGATDARPRRRKPARLLEATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEEPWTQNQQKLLELALQQYPRGSSDRWDKIARCVPSKSKEDCIARYKLLVELVQKKKQAKS", "length": 554 }, "evidence": [ { "id": "F1MJX8", "url": "https://omabrowser.org/oma/group/F1MJX8/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VWL4-1", "protein_name": "DnaJ homolog subfamily C member 1", "gene_name": "Dmel\\CG7556", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MMMRPELTLAGLLLLCATGASAWHSEELEIFDLVEEVNRNFYEFMGINQTATGAEVKRAFRTLSIVLHPDKNPAEDANIQFRNLVSIYEVLKDPSRREKYDRVLKEGMPNWKSALYYYRRMRKIGLYEGAFILFLITTVGQYLFAWAAYLEKKYTAEQVFGTKLKKLQKKNKNIDMDVILSEIPMPSLLNTLPIQIPLALWNLPRTIKNGFSKANELKELALEKRRQELEAVRRQEELEREAEEQARLRKEHKENLRKRKQNSKAPEKTEEELRGYSQIQTRELTDDDAVRPASQKSTVSGGFWTDEDLTELIRLVKKYPGGAGSRWNTIAESMNRSVQEVTFMAAKMKENGYRIPGQTDSVAEALVQESQQAQRKEKVKKAAANAGASAEKSMLIPETNWTQEQQRALEAAIVKYRKTAGGDRWQKIANSVPEKTKEECLVRYKYLCELVKTQKRAEEEANEPDEDAAAIEEELPEEEPLAPPEPEVAPAAKKLSKREQRRRKRDLSSGEDSDDAYQYEIS", "length": 522 }, "evidence": [ { "id": "F1MJX8", "url": "https://omabrowser.org/oma/group/F1MJX8/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MJX8", "url": "https://www.uniprot.org/uniprotkb/F1MJX8" } ], "pmid": "" }, { "name": "protein-folding chaperone binding", "id": "GO:0051087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "evidence": [ { "database": "UniProtKB", "id": "F1MJX8", "url": "https://www.uniprot.org/uniprotkb/F1MJX8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MJX8", "url": "https://www.uniprot.org/uniprotkb/F1MJX8" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "F1MJX8", "url": "https://www.uniprot.org/uniprotkb/F1MJX8" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "F1MJX8", "url": "https://www.uniprot.org/uniprotkb/F1MJX8" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "F1MJX8", "url": "https://www.uniprot.org/uniprotkb/F1MJX8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of protein secretion", "id": "GO:0050708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050708", "evidence": [ { "database": "UniProtKB", "id": "F1MJX8", "url": "https://www.uniprot.org/uniprotkb/F1MJX8" } ], "pmid": "" }, { "name": "regulation of protein metabolic process", "id": "GO:0051246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051246", "evidence": [ { "database": "UniProtKB", "id": "F1MJX8", "url": "https://www.uniprot.org/uniprotkb/F1MJX8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 315, "end_pos": 317, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MJX8-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 542, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MJX8-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MJX8" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MJX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJX8" }, { "id": "PS50076", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50076" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "J", "eco_id": "ECO_0000259", "start_pos": 58, "end_pos": 122, "start_aa": "Asn", "end_aa": "Leu", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJX8" }, { "id": "PS50090", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50090" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Myb-like", "eco_id": "ECO_0000259", "start_pos": 477, "end_pos": 531, "start_aa": "Arg", "end_aa": "Val", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MJX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJX8" }, { "id": "PS51293", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51293" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "SANT", "eco_id": "ECO_0000259", "start_pos": 480, "end_pos": 535, "start_aa": "Ala", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 344 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 315, "end_pos": 317 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], 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"https://www.uniprot.org/uniprotkb/F1MK16" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1MK16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MK16/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Odorant receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MK16", "url": "https://www.uniprot.org/uniprotkb/F1MK16#function" }, { "database": "UniProtKB", "id": "ARBA00002936", "url": "https://www.uniprot.org/uniprotkb/ARBA00002936#function" } ] }, { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MK16", "url": "https://www.uniprot.org/uniprotkb/F1MK16#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MK16", "url": "https://www.uniprot.org/uniprotkb/F1MK16" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR14J12", "url": "https://www.uniprot.org/uniprotkb/F1MK16", "locus": { "chromosome": "23", "start_pos": 29407731, "end_pos": 29408693, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000013654", "url": "https://www.ensembl.org/id/ENSBTAG00000013654" } ] } } ], "crossref": [ { "id": "F1MK16", "url": "https://alphafold.ebi.ac.uk/entry/F1MK16", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000013654", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000013654", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15227", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15227", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000276", 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"MNTSHFLALLFLGSPQGQNRSKSASLYAPYNFSDHCQDSVDPLVFIVTSYSIETIVGVLGNLCLICVTIRQKEKANVTNLLIANLAFSDFLMCLICQPLTAIYTIMDYWVFGEVLCKISTFIQCMSVTVSILSLVLVALERHQLITNPTGWKPSVTQAYLGIVVIWLIACFLSLPFLANSILENVFHKNHSKAVEFLADKVVCTESWPLDHHRIIYTTFLLLFQYCIPLAFILVCYVRIYQRLRNQRQVFHKGTCSSRAWQMKRINGILVAMVAAFAVLWLPLHVFNSLEDWYHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSVPVEESEHLPLSTVHTEVSKGSLRLSGRSNPI", "length": 377, "header": "tr|F1MKB6-1|F1MKB6_BOVIN Isoform 1 of Neuropeptide Y receptor type 1 OS=Bos taurus OX=9913 GN=PPYR1 PE=3 SV=2 CANONICAL=F1MKB6-1" }, "isoforms": [ { "isoform_ac": "F1MKB6-1", "url": "https://www.uniprot.org/uniprotkb/F1MKB6/entry", "sequence": { "sequence": "MNTSHFLALLFLGSPQGQNRSKSASLYAPYNFSDHCQDSVDPLVFIVTSYSIETIVGVLGNLCLICVTIRQKEKANVTNLLIANLAFSDFLMCLICQPLTAIYTIMDYWVFGEVLCKISTFIQCMSVTVSILSLVLVALERHQLITNPTGWKPSVTQAYLGIVVIWLIACFLSLPFLANSILENVFHKNHSKAVEFLADKVVCTESWPLDHHRIIYTTFLLLFQYCIPLAFILVCYVRIYQRLRNQRQVFHKGTCSSRAWQMKRINGILVAMVAAFAVLWLPLHVFNSLEDWYHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSVPVEESEHLPLSTVHTEVSKGSLRLSGRSNPI", "length": 377, "header": "tr|F1MKB6-1|F1MKB6_BOVIN Isoform 1 of Neuropeptide Y receptor type 1 OS=Bos taurus OX=9913 GN=PPYR1 PE=3 SV=2 CANONICAL=F1MKB6-1" }, "locus": { "chromosome": "28", "start_pos": 41917409, "end_pos": 41916580, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006247.7", "url": "https://www.ensembl.org/id/ENSBTAT00000006247.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006247.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006247.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:505889", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:505889", "resource": "KEGG Pathway" }, { "id": "R-BTA-375276", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-375276", "resource": "Reactome", "description": "Peptide ligand-binding receptors" }, { "id": "R-BTA-418594", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-418594", "resource": "Reactome", "description": "G alpha (i) signalling events" } ], "orthologs": [ { "uniprot_canonical_ac": "P0DQD5-1", "protein_name": "Neuropeptide Y receptor type 4-2", "gene_name": "NPY4R2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSILENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTEVSKGSLRLSGRSNPI", "length": 375 }, "evidence": [ { "id": "F1MKB6", "url": "https://omabrowser.org/oma/group/F1MKB6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MKB6", "url": "https://www.uniprot.org/uniprotkb/F1MKB6" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "F1MKB6", "url": "https://www.uniprot.org/uniprotkb/F1MKB6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "neuropeptide signaling pathway", "id": "GO:0007218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007218", "evidence": [ { "database": "UniProtKB", "id": "F1MKB6", "url": "https://www.uniprot.org/uniprotkb/F1MKB6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "peptide YY receptor activity", "id": "GO:0001601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001601", "evidence": [ { "database": "UniProtKB", "id": "F1MKB6", "url": "https://www.uniprot.org/uniprotkb/F1MKB6" } ], "pmid": "" }, { "name": "pancreatic polypeptide receptor activity", "id": "GO:0001602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001602", "evidence": [ { "database": "UniProtKB", "id": "F1MKB6", "url": "https://www.uniprot.org/uniprotkb/F1MKB6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 189, "end_pos": 191, "annotation": "n_glycosylation_sequon" }, { "start_pos": 19, "end_pos": 21, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2, "end_pos": 4, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" }, { "start_pos": 76, "end_pos": 78, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MKB6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 377, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MKB6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MKB6" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MKB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKB6" }, { "id": "PS50262", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50262" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-protein coupled receptors family 1 profile", "eco_id": "ECO_0000259", "start_pos": 60, "end_pos": 324, "start_aa": "Gly", "end_aa": "Tyr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 189, "end_pos": 191 }, { "start_pos": 19, "end_pos": 21 }, { "start_pos": 2, "end_pos": 4 }, { "start_pos": 31, "end_pos": 33 }, { "start_pos": 76, "end_pos": 78 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MKC6-1", "uniprot_ac": "F1MKC6", "uniprot_id": "F1MKC6_BOVIN", "mass": { "chemical_mass": 34013.0, "monoisotopic_mass": 34013.0 }, "refseq": {}, "gene_names": [ { "name": "MS4A1", "type": "recommended", "evidence": [ { "id": "F1MKC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC6" } ] } ], "protein_names": [ { "name": "Membrane spanning 4-domains A1", "type": "synonym", "evidence": [ { "id": "F1MKC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKC6/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MKC6", "url": "https://www.uniprot.org/uniprotkb/F1MKC6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "MS4A1", "url": "https://www.uniprot.org/uniprotkb/F1MKC6", "locus": { "chromosome": "15", "start_pos": 83298115, "end_pos": 83282895, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000004580", "url": "https://www.ensembl.org/id/ENSBTAG00000004580" } ] } } ], "crossref": [ { "id": "F1MKC6", "url": "https://alphafold.ebi.ac.uk/entry/F1MKC6", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000004580", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000004580", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR007237", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007237", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "HFFKMES", "url": "https://omabrowser.org/oma/group/HFFKMES/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MKC6", "url": "https://www.orthodb.org/?gene=F1MKC6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23320", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23320", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23320:SF79", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23320:SF79", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04103", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF04103", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MKC6", "url": "https://www.uniprot.org/uniprotkb/F1MKC6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKC6-1", "url": "https://www.uniprot.org/uniprotkb/F1MKC6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTPRNSMVGAFPAEPLKGPIAMHAAQKVVPRRVPVVVGPTQSFFMREAKALGAVQIMNGLFHIALGSLMLIHMDVYMPICVTLWYPLWGGIMFIISGSLLAAAEKNSTQSMLTGRLIMNSLSLFAAISGIIFLIMDIFNMTISHFFKMENLNLIKTQVPYININNCERANPDENNSQSVEYCARIRFVFLSNFAVMMIFAFLQKLVTAGTVENEWKKLCSRPKANVVLLSAEEKKEQAIEIKEEVVEQIEVAEQIEISSLPKNEEDIEIIPVQEEEEEEAEMNFPEPPQDQEDSPIENDSVP", "length": 303, "header": "tr|F1MKC6-1|F1MKC6_BOVIN Isoform 1 of Membrane spanning 4-domains A1 OS=Bos taurus OX=9913 GN=MS4A1 PE=3 SV=3 CANONICAL=F1MKC6-1" }, "isoforms": [ { "isoform_ac": "F1MKC6-1", "url": "https://www.uniprot.org/uniprotkb/F1MKC6/entry", "sequence": { "sequence": "MTTPRNSMVGAFPAEPLKGPIAMHAAQKVVPRRVPVVVGPTQSFFMREAKALGAVQIMNGLFHIALGSLMLIHMDVYMPICVTLWYPLWGGIMFIISGSLLAAAEKNSTQSMLTGRLIMNSLSLFAAISGIIFLIMDIFNMTISHFFKMENLNLIKTQVPYININNCERANPDENNSQSVEYCARIRFVFLSNFAVMMIFAFLQKLVTAGTVENEWKKLCSRPKANVVLLSAEEKKEQAIEIKEEVVEQIEVAEQIEISSLPKNEEDIEIIPVQEEEEEEAEMNFPEPPQDQEDSPIENDSVP", "length": 303, "header": "tr|F1MKC6-1|F1MKC6_BOVIN Isoform 1 of Membrane spanning 4-domains A1 OS=Bos taurus OX=9913 GN=MS4A1 PE=3 SV=3 CANONICAL=F1MKC6-1" }, "locus": { "chromosome": "15", "start_pos": 83297163, "end_pos": 83291169, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000006236.6", "url": "https://www.ensembl.org/id/ENSBTAT00000006236.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000006236.5", "url": "https://www.ensembl.org/id/ENSBTAP00000006236.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 41, "start_aa": "Thr", "end_pos": 41, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr41", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8W4FLH7-1", "protein_name": "Membrane spanning 4-domains A1", "gene_name": "MS4A1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MTTPRNSMIGAFPADPVKGPIAMQPVPKLIPRRVPSMGPTQSFFMRESKALGAVQIMNGLFHMTLGSLLLFHMEVYAPICVTLWYPLWGGLLYIISGSFLAAAEKSPRKSLVKARMVMNSLSLFAAISGIIFLIMDIFNITISHFKMENLNLIKTPTPYINIYDCEPANLAEKNSLSMRYCESMRAVFLSTFAVMLIFAFLQKFVTAGTVENEWKKMCSRPKANVVLLSAEEKKEQAIEIKEEVVEQTEIPSQPKNEEEIEIIPVQEEEEEEEEETEINFPEPPQDEESSPIENDSAP", "length": 298 }, "evidence": [ { "id": "F1MKC6", "url": "https://omabrowser.org/oma/group/F1MKC6/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A9J7GSD9-1", "protein_name": "B-lymphocyte antigen CD20", "gene_name": "LOC100753107", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MTTPRNSVSGTFPIESTRGPLAMQASQKRNLRRPSSLVGPTQSFFMRESKALGAVQIMNGLFHISLGGLLMIPTGVFAPICMSVWYPLWGGIMYIISGSLLAAAAEQTSRKSLVKAKVIMNSLSLFAAISGIILSIMDILNITVSHFLKMERLILSKTPNLYVDIYNCEPSNSSEKNSPSTQYCYSMQSVFLGILSVMLISAFFQKLVTAGVVENDWRRMCSRPKSNVVLLSAGEKKEQTIKMKEEIIELSGVSSQPKNEEEIEIIPVQEEEEETEINFPEPPQEQESLPVENEIAP", "length": 297 }, "evidence": [ { "id": "F1MKC6", "url": "https://omabrowser.org/oma/group/F1MKC6/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "D4A4Y3-1", "protein_name": "Membrane spanning 4-domains A1", "gene_name": "Ms4a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTTPRNSVSGPFPTEPTKGPLAMQPAQKVIPRRPSSLVGPTQSFFMRESKALGAVQIMNGLFHISLGGLLMIPTGVFAPICLSVWYPLWGGIMYIISGSLLAAAAEKTSRKSLVKAKVIMSSLSLFAAISGIILSIMDILNITVSHFLKMERLELIKTPKLYVDIYNCEPSNSSEKNSPSTQYCNSVQSVFLGILSVMLISAFFQKLVTAGVVENEWKRVCSRPKSNVVLLSAGEKKEQTIKMKEEIIELSGVSSQPKNEEEIEIIPVQEEEEEEAEINFPAPPQEQESLPVENEISP", "length": 298 }, "evidence": [ { "id": "F1MKC6", "url": "https://omabrowser.org/oma/group/F1MKC6/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P11836-1", "protein_name": "B-lymphocyte antigen CD20", "gene_name": "MS4A1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP", "length": 297 }, "evidence": [ { "id": "F1MKC6", "url": "https://omabrowser.org/oma/group/F1MKC6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P19437-1", "protein_name": "B-lymphocyte antigen CD20", "gene_name": "Ms4a1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGPFPAEPTKGPLAMQPAPKVNLKRTSSLVGPTQSFFMRESKALGAVQIMNGLFHITLGGLLMIPTGVFAPICLSVWYPLWGGIMYIISGSLLAAAAEKTSRKSLVKAKVIMSSLSLFAAISGIILSIMDILNMTLSHFLKMRRLELIQTSKPYVDIYDCEPSNSSEKNSPSTQYCNSIQSVFLGILSAMLISAFFQKLVTAGIVENEWKRMCTRSKSNVVLLSAGEKNEQTIKMKEEIIELSGVSSQPKNEEEIEIIPVQEEEEEEAEINFPAPPQEQESLPVENEIAP", "length": 291 }, "evidence": [ { "id": "F1MKC6", "url": "https://omabrowser.org/oma/group/F1MKC6/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MKC6", "url": "https://www.uniprot.org/uniprotkb/F1MKC6" } ], "pmid": "" }, { "name": "plasma membrane raft", "id": "GO:0044853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044853", "evidence": [ { "database": "UniProtKB", "id": "F1MKC6", "url": "https://www.uniprot.org/uniprotkb/F1MKC6" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "F1MKC6", "url": "https://www.uniprot.org/uniprotkb/F1MKC6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "F1MKC6", "url": "https://www.uniprot.org/uniprotkb/F1MKC6" } ], "pmid": "" }, { "name": "protein tetramerization", "id": "GO:0051262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051262", "evidence": [ { "database": "UniProtKB", "id": "F1MKC6", "url": "https://www.uniprot.org/uniprotkb/F1MKC6" } ], "pmid": "" }, { "name": "B cell receptor signaling pathway", "id": "GO:0050853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050853", "evidence": [ { "database": "UniProtKB", "id": "F1MKC6", "url": "https://www.uniprot.org/uniprotkb/F1MKC6" } ], "pmid": "" }, { "name": "B cell differentiation", "id": "GO:0030183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030183", "evidence": [ { "database": "UniProtKB", "id": "F1MKC6", "url": "https://www.uniprot.org/uniprotkb/F1MKC6" } ], "pmid": "" }, { "name": "positive regulation of calcium ion import across plasma membrane", "id": "GO:1905665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905665", "evidence": [ { "database": "UniProtKB", "id": "F1MKC6", "url": "https://www.uniprot.org/uniprotkb/F1MKC6" } ], "pmid": "" }, { "name": "store-operated calcium entry", "id": "GO:0002115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002115", "evidence": [ { "database": "UniProtKB", "id": "F1MKC6", "url": "https://www.uniprot.org/uniprotkb/F1MKC6" } ], "pmid": "" }, { "name": "calcium ion import into cytosol", "id": "GO:1902656", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902656", "evidence": [ { "database": "UniProtKB", "id": "F1MKC6", "url": "https://www.uniprot.org/uniprotkb/F1MKC6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1MKC6", "url": "https://www.uniprot.org/uniprotkb/F1MKC6" } ], "pmid": "" }, { "name": "immunoglobulin binding", "id": "GO:0019865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019865", "evidence": [ { "database": "UniProtKB", "id": "F1MKC6", "url": "https://www.uniprot.org/uniprotkb/F1MKC6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 299, "end_pos": 301, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MKC6-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 303, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MKC6-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MKC6" } ], "lectin_list": [], "domain_list": [], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 41 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 107, "end_pos": 109 }, { "start_pos": 140, "end_pos": 142 }, { "start_pos": 175, "end_pos": 177 }, { "start_pos": 299, "end_pos": 301 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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}, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MKF7-1", "uniprot_ac": "F1MKF7", "uniprot_id": "F1MKF7_BOVIN", "mass": { "chemical_mass": 35225.0, "monoisotopic_mass": 35225.0 }, "refseq": { "ac": "XP_002684746", "name": "olfactory receptor 5K3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684746" }, "gene_names": [ { "name": "OR5K8", "type": "recommended", "evidence": [ { "id": "F1MKF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKF7" } ] }, { "name": "OR5K8", "type": "synonym", "evidence": [ { "id": "XP_002684746", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684746" } ] } ], "protein_names": [ { "name": "Olfactory receptor", "type": "recommended", "evidence": [ { "id": "F1MKF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKF7/entry#names_and_taxonomy" } ] }, { "name": "olfactory receptor 5K3", "type": "synonym", "evidence": [ { "id": "XP_002684746", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684746" } ] } ], "function": [ { "annotation": "Putative odorant or sperm cell receptor.", "evidence": [ { "database": "UniProtKB", "id": "F1MKF7", "url": "https://www.uniprot.org/uniprotkb/F1MKF7#function" }, { "database": "UniProtKB", "id": "ARBA00003929", "url": "https://www.uniprot.org/uniprotkb/ARBA00003929#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MKF7", "url": "https://www.uniprot.org/uniprotkb/F1MKF7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "OR5K8", "url": "https://www.uniprot.org/uniprotkb/F1MKF7", "locus": {} } ], "crossref": [ { "id": "F1MKF7", "url": "https://alphafold.ebi.ac.uk/entry/F1MKF7", "database": "AlphaFoldDB", "categories": [] }, { "id": "785848", "url": "https://www.ncbi.nlm.nih.gov/gene/785848", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000725", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000725", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785848", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785848", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TYHPKLK", "url": "https://omabrowser.org/oma/group/TYHPKLK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MKF7", "url": "https://www.orthodb.org/?gene=F1MKF7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48018", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48018", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13853", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13853", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002684746", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684746", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MKF7", "url": "https://www.uniprot.org/uniprotkb/F1MKF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKF7-1", "url": "https://www.uniprot.org/uniprotkb/F1MKF7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTEDNHSLTTEFILIGFTNHPELKTLLFQVFFTIYLITMVGNLGLVALIVTEHRLHTPMYIFLGNLALMDSCCSCAITPKILENLFSKDRMISLYECMAQFYCLCLAETTDCFLLAAMAYDRYVAICKPLQYHTMMSKKLCIQMTTGAYIAGNIHPMIHVGLLFRLTFCKSHQINHFLCDVLPLYRHSCVDPYINELMIFIFAGSVLVFTITTVIISYLFILFTIFKMKSKEGKGKALSTCASHFLSVSIFYGSLLFMYVRPNSVNDEDKDIPVAIFYTLVIPLLNPFIYSLRNKEVINAMKKIMKNL", "length": 308, "header": "tr|F1MKF7-1|F1MKF7_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5K8 PE=3 SV=2 CANONICAL=F1MKF7-1" }, "isoforms": [ { "isoform_ac": "F1MKF7-1", "url": "https://www.uniprot.org/uniprotkb/F1MKF7/entry", "sequence": { "sequence": "MTEDNHSLTTEFILIGFTNHPELKTLLFQVFFTIYLITMVGNLGLVALIVTEHRLHTPMYIFLGNLALMDSCCSCAITPKILENLFSKDRMISLYECMAQFYCLCLAETTDCFLLAAMAYDRYVAICKPLQYHTMMSKKLCIQMTTGAYIAGNIHPMIHVGLLFRLTFCKSHQINHFLCDVLPLYRHSCVDPYINELMIFIFAGSVLVFTITTVIISYLFILFTIFKMKSKEGKGKALSTCASHFLSVSIFYGSLLFMYVRPNSVNDEDKDIPVAIFYTLVIPLLNPFIYSLRNKEVINAMKKIMKNL", "length": 308, "header": "tr|F1MKF7-1|F1MKF7_BOVIN Isoform 1 of Olfactory receptor OS=Bos taurus OX=9913 GN=OR5K8 PE=3 SV=2 CANONICAL=F1MKF7-1" }, "locus": { "chromosome": "1", "start_pos": 42736332, "end_pos": 42735409, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000054123.3", "url": "https://www.ensembl.org/id/ENSBTAT00000054123.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049610.2", "url": "https://www.ensembl.org/id/ENSBTAP00000049610.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:785848", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785848", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AS28-1", "protein_name": "Olfactory receptor", "gene_name": "Or5k3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAEDNYSLTTEFILVGFSDHPDLKILLFLVFTAIYLVTMVGNLGLVALIYMEPRLHTPMYIFLGNLALMDSCCSCAITPKMLENFFSVDRRISLYECMAQFYFLCLAETTDCFLLAAMAYDRYVAICNPLQYHTMMSKKLCVQMTTGAYIAGNLHPMIEVGLLLRLTFCRSHVIKHFFCDVLPLYGISCTDPHINELILLVLAGSIQVFTITIVLVSYSCILFTIFSMKSKEGRGKALSTCASHFLSVSIFYGSLLFMYAQPHSVNEGDKDVPVAIFYTLVIPLLNPFIYSLRNKEVINAMKRTMRKR", "length": 308 }, "evidence": [ { "id": "F1MKF7", "url": "https://omabrowser.org/oma/group/F1MKF7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A6NET4-1", "protein_name": "Olfactory receptor 5K3", "gene_name": "OR5K3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNKENHSLIAEFILTGFTYHPKLKTVLFVVFFAIYLITMVGNIGLVALIYIEQRLHTPMYIFLGNLVLMDSCCSSAITPKMLENFFSEDKRITLYECMAQFYFLCLAETTDCFLLAAMAYDCYVAICNPLQYHTMMSKTLCIQMTAGAYLAGNLHPMIEVEFLLRLTFCGSHQINHFFCDVLPLYRLSCINPYINELVLFILAGSIQIFTIVLVSYFYILFTIFTMKSKEGRGKALSTCASHFLSVSIFCDSLLFMYARPGAVNEGDKDIPVAIFYTLVIPLLNPFIYSLRNKEVINIMKKIMKKRKFCHILKQMSSPLAT", "length": 321 }, "evidence": [ { "id": "F1MKF7", "url": "https://omabrowser.org/oma/group/F1MKF7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8VGQ6-1", "protein_name": "Olfactory receptor", "gene_name": "Or5k3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAENNYSVTNEFILVGFSDHPDLKTPLFLVFSAIYLVTMVGNLGLVALIYMEPRLHTPMYIFLGNLALMDSCCSCAITPKMLENFFSVDRRISLYECMVQFYFLCLAETTDCFLLAAMAYDRYVAICNPLQYHSMMSKKLCLQMTMGSYIAGNLHPMIEVGLLLRLTFCRSHVIKHFFCDVLPLYRISCTDPNINELILLVLAGSIQVFTISIVLVSYSCILFTIFTMKSKEGRGKALSTCASHFLSVSIFYGSLLFMYAQPHSANEGDKDMPVAIFYTLIIPLLNPFIYSLRNKEVINVMKKTMKRR", "length": 308 }, "evidence": [ { "id": "F1MKF7", "url": "https://omabrowser.org/oma/group/F1MKF7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "F1MKF7", "url": "https://www.uniprot.org/uniprotkb/F1MKF7" } ], "pmid": "" }, { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "F1MKF7", "url": "https://www.uniprot.org/uniprotkb/F1MKF7" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "F1MKF7", "url": "https://www.uniprot.org/uniprotkb/F1MKF7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MKF7", "url": "https://www.uniprot.org/uniprotkb/F1MKF7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MKF7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 308, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MKF7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MKF7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MKF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKF7" }, { 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complex that is involved in the histone 3'-end pre-mRNA processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA.", "evidence": [ { "database": "UniProtKB", "id": "F1MKH0", "url": "https://www.uniprot.org/uniprotkb/F1MKH0#function" }, { "database": "UniProtKB", "id": "ARBA00058923", "url": "https://www.uniprot.org/uniprotkb/ARBA00058923#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MKH0", "url": "https://www.uniprot.org/uniprotkb/F1MKH0" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LSM11", "url": "https://www.uniprot.org/uniprotkb/F1MKH0", "locus": { "chromosome": "7", "start_pos": 69338120, "end_pos": 69328742, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000010363", "url": "https://www.ensembl.org/id/ENSBTAG00000010363" } ] } } ], "crossref": [ { "id": "F1MKH0", "url": "https://alphafold.ebi.ac.uk/entry/F1MKH0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000010363", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000010363", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01739", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01739", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "785718", "url": "https://www.ncbi.nlm.nih.gov/gene/785718", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001163", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001163", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010920", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010920", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034109", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034109", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR060343", "url": "https://www.ebi.ac.uk/interpro/entry/IPR060343", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:785718", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785718", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QETSECA", "url": "https://omabrowser.org/oma/group/QETSECA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MKH0", "url": "https://www.orthodb.org/?gene=F1MKH0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21415", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21415", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21415:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21415:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF28412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF28412", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-111367", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111367", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-73856", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73856", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-77588", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77588", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002707877", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002707877", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MKH0", "url": "https://www.uniprot.org/uniprotkb/F1MKH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKH0-1", "url": "https://www.uniprot.org/uniprotkb/F1MKH0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEERERGARSARAGSPARPPSPRLDVSSDSFDPLLALYAPHLPPIPYPNAPCFNNVAEYESFLRTGLRSGGRGRARGAAAGSGGPAAAAGPSGRTRRRPDAPAPDPERIQRLRRLMVAKEEGDEAADARRRGPGRSRKAPRNVLTRMPLHEGSPLGELHRCIREGVKVNVHIRTFKGLRGVCTGFLVAFDKFWNMALTDVDETYRKPVLGKAYERDSSLTLTRLFDRLKLQDSSKKETDSKSAVEDSTLSRYSQTSTWKVASVWGRGDTDRSSRRRSRSVPSSLQASAREESRSELSGRTTRTEGSSAGGTFSRATTLSRGPSRKKKRKPKVDYQQVFTRHINQIFIRGENVLLVHLAQ", "length": 359, "header": "tr|F1MKH0-1|F1MKH0_BOVIN Isoform 1 of U7 snRNA-associated Sm-like protein LSm11 OS=Bos taurus OX=9913 GN=LSM11 PE=3 SV=3 CANONICAL=F1MKH0-1" }, "isoforms": [ { "isoform_ac": "F1MKH0-1", "url": "https://www.uniprot.org/uniprotkb/F1MKH0/entry", "sequence": { "sequence": 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[ { "id": "bta:785718", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:785718", "resource": "KEGG Pathway" }, { "id": "R-BTA-111367", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-111367", "resource": "Reactome", "description": "SLBP independent Processing of Histone Pre-mRNAs" }, { "id": "R-BTA-73856", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73856", "resource": "Reactome", "description": "RNA Polymerase II Transcription Termination" }, { "id": "R-BTA-77588", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-77588", "resource": "Reactome", "description": "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YJU4-1", "protein_name": "LSM11, U7 small nuclear RNA associated", "gene_name": "LSM11", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MEEDEGAAGGAEQRHPRRRPGAERSPSPSRLDVSSSRFDPLLALYSADTPLPFPAAPCFNNLAEYESFQRGLLRPRGRRGPSARRGPSAGRSARRGPPAADPERIQRLRSLMVNAGPEQDAAGSGTARRRRAPRNVLTRMPLHEGSPLGELHRCVRDGVKINVHIRTFKGLRGVCTGFLVAFDKFWNMALTDVDETYRKPVLGKAFYAEPQLSLTRLFDRLKLQDASVKKGADSKTLSGELALTNDSQTSGWKVGSGRGREEDEREKQKRLGRGGEKKVPGDGLHLAARGEADVGSGTAHTGGATAGGTRTRSQARRKRRPKVDYQQVFTRHINQIFIRGENVLLVHLAH", "length": 350 }, "evidence": [ { "id": "F1MKH0", "url": "https://omabrowser.org/oma/group/F1MKH0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "E9QIK5-1", "protein_name": "U7 snRNA-associated Sm-like protein LSm11", "gene_name": "lsm11", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEEGERKSESVRCPASSQTSDQQNTTESTGQNPETDEDDVETKLDIRSDKFDPLLALYSPQVPLPYPNIKCFNNIAEYESFMKGGRGRAKPENVEKRLRKAQKGKADPERIERLKRLMVNNPVPEEGEGSGVKRPPRQRKTAKNVLTRMPLHTGSPLGQLNRCVQEKIRVKVHIRTFKGLRGVCSGFVVAFDKFWNLAMVDVDETYREPLLGQALYHEKALTITRLFEKLKVQETAALSAVERKQGDKLLKSDPRSGSSQLKDQSRRSDSRHNKEKPELSEIDKSTSSREMQKPESRPKVEYGRVHTRHVNQLFIRGENVLLVNIQQD", "length": 328 }, "evidence": [ { "id": "F1MKH0", "url": "https://omabrowser.org/oma/group/F1MKH0/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P83369-1", "protein_name": "U7 snRNA-associated Sm-like protein LSm11", "gene_name": "LSM11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEERERGARSAGAGSPARPPSPRLDVSSDSFDPLLALYAPRLPPIPYPNAPCFNNVAEYESFLRTGVRGGGRGRGRARGAAAGSGVPAAPGPSGRTRRRPDAPAPDPERIQRLRRLMVAKEEGDGAAGAGRRGPGRSRKAPRNVLTRMPLHEGSPLGELHRCIREGVKVNVHIRTFKGLRGVCTGFLVAFDKFWNMALTDVDETYRKPVLGKAYERDSSLTLTRLFDRLKLQDSSKKEADSKSAVEDSTLSRYSQTSTWKLASVWGRADTGRGSHKRSRSVPSSLQASAREESRSELSGRTTRTDGSSVGGTFSRATTLSRGQSRKKKRKPKVDYQQVFTRHINQIFIRGENVLLVHLAQ", "length": 360 }, "evidence": [ { "id": "F1MKH0", "url": "https://omabrowser.org/oma/group/F1MKH0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BUV6-1", "protein_name": "U7 snRNA-associated Sm-like protein LSm11", "gene_name": "Lsm11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"evidence": [ { "database": "UniProtKB", "id": "F1MKH0", "url": "https://www.uniprot.org/uniprotkb/F1MKH0" } ], "pmid": "" }, { "name": "telomerase holoenzyme complex", "id": "GO:0005697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005697", "evidence": [ { "database": "UniProtKB", "id": "F1MKH0", "url": "https://www.uniprot.org/uniprotkb/F1MKH0" } ], "pmid": "" }, { "name": "U7 snRNP", "id": "GO:0005683", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005683", "evidence": [ { "database": "UniProtKB", "id": "F1MKH0", "url": "https://www.uniprot.org/uniprotkb/F1MKH0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "positive regulation of G1/S transition of mitotic cell cycle", "id": "GO:1900087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900087", "evidence": [ { "database": "UniProtKB", "id": "F1MKH0", "url": "https://www.uniprot.org/uniprotkb/F1MKH0" } ], "pmid": "" }, { "name": "mRNA 3'-end processing by stem-loop binding and 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"common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PAG12", "url": "https://www.uniprot.org/uniprotkb/F1MKK1", "locus": { "chromosome": "29", "start_pos": 37666176, "end_pos": 37655961, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000019173", "url": "https://www.ensembl.org/id/ENSBTAG00000019173" } ] } } ], "crossref": [ { "id": "F1MKK1", "url": "https://alphafold.ebi.ac.uk/entry/F1MKK1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000019173", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000019173", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSBTAG00000033096", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000033096", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR001461", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001461", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": 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"categories": [ "Protein" ] }, { "id": "M0QW08-1", "url": "https://www.uniprot.org/uniprotkb/M0QW08-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKWLVLLGLVALSECIVILPLRKMKTLRETLREKNLLNNFLEERAYRLSKRDSKITIHPLKNYLDMAYVGNITIGTPPQEFRVVFDTGSADLWVPSISCVSPACYTHKTFNLHNSSSFGQTHQPISISYGPGIIQGFLGSDTVRIGNLVSLKQSFGLSQEEYGFDGAPFDGVLGLTYPSISIKGIIPIFDNLWSQGAFSEPVFAFYLNTCKPEGSVVMFGGVDHRYYKGELNWIPVSQTRYWQISMNRISMNGNVTACSRGCQALLDTRTSMIHGPTRLITNIHKLMNARHQGSEYVVSCDAVKTLPPVIFNINGIDYPLPPQAYITKAQNFCLSIFHGGTETSSPETWILGGVFLRQYFSVFDRRNDRIGLALAV", "length": 376, "header": "tr|F1MKK1-1|F1MKK1_BOVIN Isoform 1 of Pregnancy-associated glycoprotein 12 OS=Bos taurus OX=9913 GN=PAG12 PE=3 SV=3 CANONICAL=F1MKK1-1" }, "isoforms": [ { "isoform_ac": "F1MKK1-1", "url": "https://www.uniprot.org/uniprotkb/F1MKK1/entry", "sequence": { "sequence": 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{ "sequence": "ILPLRKMKTLRETLREKNLLNNFLEERAYRLSKRDSKITIHPLKNYLDMAYVGNITIGTPPQEFRVVFDTGSADLWVPSISCVSPACYTHKTFNLHNSSSFGQTHQPISISYGPGIIQGFLGSDTVRIGNLVSLKQSFGLSQEEYGFDGAPFDGVLGLTYPSISIKGIIPIFDNLWSQGAFSEPVFAFYLNTCKPEGSVVMFGGVDHRYYKGELNWIPVSQTRYWQISMNRISMNGNVTACSRGCQALLDTRTSMIHGPTRLITNIHKLMNARHQGSEYVVSCDAVKTLPPVIFNINGIDYPLPPQAYITKAQNFCLSIFHGGTETSSPETWILGGVFLRQYFSVFDRRNDRIGLALAV", "length": 359, "header": "tr|M0QW08-1|F1MKK1_BOVIN Computationally mapped isoform of Pregnancy-associated glycoprotein 12 OS=Bos taurus OX=9913 GN=PAG12 PE=3 SV=3 CANONICAL=F1MKK1-1" }, "locus": { "chromosome": "29", "start_pos": 37666170, "end_pos": 37658078, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000016233.7", "url": "https://www.ensembl.org/id/ENSBTAT00000016233.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000016233.7", "url": "https://www.ensembl.org/id/ENSBTAP00000016233.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], 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"field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MKP3-1", "uniprot_ac": "F1MKP3", "uniprot_id": "F1MKP3_BOVIN", "mass": { "chemical_mass": 35015.0, "monoisotopic_mass": 35015.0 }, "refseq": { "ac": "NP_001377260", "name": "olfactory receptor family 6 subfamily C member 2F", "summary": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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"description": "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" }, { "id": "R-BTA-73863", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-73863", "resource": "Reactome", "description": "RNA Polymerase I Transcription Termination" }, { "id": "R-BTA-75953", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-75953", "resource": "Reactome", "description": "RNA Polymerase II Transcription Initiation" }, { "id": "R-BTA-76042", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76042", "resource": "Reactome", "description": "RNA Polymerase II Transcription Initiation And Promoter Clearance" }, { "id": "R-BTA-76061", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76061", "resource": "Reactome", "description": "RNA Polymerase III Transcription Initiation From Type 1 Promoter" }, { "id": "R-BTA-76066", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76066", "resource": "Reactome", "description": "RNA Polymerase III Transcription Initiation From Type 2 Promoter" }, { "id": "R-BTA-76071", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-76071", "resource": "Reactome", "description": "RNA Polymerase III Transcription Initiation From Type 3 Promoter" }, { "id": "R-BTA-9018519", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-9018519", "resource": "Reactome", "description": "Estrogen-dependent gene expression" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "F1MKV5", "url": "https://www.uniprot.org/uniprotkb/F1MKV5" } ], "pmid": "" }, { "name": "RNA polymerase II general transcription initiation factor activity", "id": "GO:0016251", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016251", "evidence": [ { "database": 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"https://alphafold.ebi.ac.uk/entry/F1MKX5", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011312", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011312", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "787396", "url": "https://www.ncbi.nlm.nih.gov/gene/787396", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020479", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020479", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050394", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050394", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:787396", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787396", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "VSQFPHS", "url": "https://omabrowser.org/oma/group/VSQFPHS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MKX5", "url": "https://www.orthodb.org/?gene=F1MKX5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24340", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24340", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24340:SF40", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24340:SF40", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00046", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_002707769", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002707769", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MKX5", "url": "https://www.uniprot.org/uniprotkb/F1MKX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKX5-1", "url": "https://www.uniprot.org/uniprotkb/F1MKX5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSLSPKHTTPFSVSDILSPIEETYKKFGGAMDGTPPGLGAPLGAAYRAPPPGPSSQAAAAAGMQPPHAMAGHNAAAAAAAAAAAAAAATYHMPPGVSQFPHGAVGGYCNGGLGNVGELPAYTDGVRGGAAAAATGWYGANPDPRYSSISRFMGPSAGVNVAGMGSLTGIADAAKSLAPLHAAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQEAVLGPPPPPSPRRVAVPVLVKDGKPCQNGAATPTPQAGPQPPAPTPELEELSPSPPALHGAGAGLAGLDAAAAGDYGGSALGANLLYGRTW", "length": 347, "header": "tr|F1MKX5-1|F1MKX5_BOVIN Isoform 1 of NK2 homeobox 4 OS=Bos taurus OX=9913 GN=NKX2-4 PE=3 SV=3 CANONICAL=F1MKX5-1" }, "isoforms": [ { "isoform_ac": "F1MKX5-1", "url": "https://www.uniprot.org/uniprotkb/F1MKX5/entry", "sequence": { "sequence": "MSLSPKHTTPFSVSDILSPIEETYKKFGGAMDGTPPGLGAPLGAAYRAPPPGPSSQAAAAAGMQPPHAMAGHNAAAAAAAAAAAAAAATYHMPPGVSQFPHGAVGGYCNGGLGNVGELPAYTDGVRGGAAAAATGWYGANPDPRYSSISRFMGPSAGVNVAGMGSLTGIADAAKSLAPLHAAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQEAVLGPPPPPSPRRVAVPVLVKDGKPCQNGAATPTPQAGPQPPAPTPELEELSPSPPALHGAGAGLAGLDAAAAGDYGGSALGANLLYGRTW", "length": 347, "header": "tr|F1MKX5-1|F1MKX5_BOVIN Isoform 1 of NK2 homeobox 4 OS=Bos taurus OX=9913 GN=NKX2-4 PE=3 SV=3 CANONICAL=F1MKX5-1" }, "locus": { "chromosome": "13", "start_pos": 40685756, "end_pos": 40684429, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015024.7", "url": "https://www.ensembl.org/id/ENSBTAT00000015024.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015024.6", "url": "https://www.ensembl.org/id/ENSBTAP00000015024.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 290, "start_aa": "Thr", "end_pos": 290, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr290", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 301, "start_aa": "Thr", "end_pos": 301, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr301", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:787396", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:787396", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZTX2-1", "protein_name": "NK2 homeobox 4", "gene_name": "Nkx2-4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLSPKHTTPFSVSDILSPIEETYKKFGGVMDGAPPGLGAPLGAAAYRAPPTGPSSQAAAVAGMQPPHAMAGHNAAAAAAAAAAAAAAAATYHMPPGVSQFPHSAMGSYCNGGLGNMGELPAYTDGMRGGAAAAATGWYGANTDPRYSSISRFMGPSAGVNVAGMGSLTGIADAAKSLAPLHAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQEGGLGPPPPPPPPSPRRVAVPVLVKDGKPCQNGAGTPTPGQGGQQPQAPTPASELEELSSSPPALHGPGGGLAALDTATGDYGGGVLGANLLYGRTW", "length": 353 }, "evidence": [ { "id": "F1MKX5", "url": "https://omabrowser.org/oma/group/F1MKX5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SAU4-1", "protein_name": "NK2 homeobox 4", "gene_name": "NKX2-4", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSLSPKHTTPFSVSDILSPIEETYKKFGGAMDSAPPGLGASLGAAAAAYRAPPPGPSSQAAAVAGMQPPHAMAGHNAAAAAAAAAAAAAAAATYHMPPGVSQFPHGAMGGYCNGGLGNMGELPAYTDGMRGGAAAAATGWYGANPDPRYSSISRFMGPSAGVNVTGMGSLTGIADAAKSLAPLHAAAAAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQEAGLGPPPPPSPRRVAVPVLVKDGKPCQNGAGPPTPGQAGPQPPAPTPAPELEELSPSPPALHGPGGGLAALDATAGDFGGGTLGANLLYGRTW", "length": 356 }, "evidence": [ { "id": "F1MKX5", "url": "https://omabrowser.org/oma/group/F1MKX5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "Q9EQM3-1", "protein_name": "Homeobox protein Nkx-2.4", "gene_name": "Nkx2-4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLSPKHTTPFSVSDILSPIEETYKKFGGVMDGAPPGLGAPLGAAAYRAPPSGPSSQAAAVAAGMQPPHAMAGHNAAAAAAAAAAAAAAAATYHMPPGVSQFPHSAMGSYCNGGLGNMGELPAYTDGMRGGAAAAATGWYGANTDPRYSSISRFMGPSAGVNVAGMGSLTGIADAAKSLAPLHAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQEGGLGPPPPPPPPSPRRVAVPVLVKDGKPCQNGAGTPTPGQGGQQPQAPTPAPELEELSPSPPALHGPGGGLAALDAATGDYGGGVLGANLLYGRTW", "length": 354 }, "evidence": [ { "id": "F1MKX5", "url": "https://omabrowser.org/oma/group/F1MKX5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9H2Z4-1", "protein_name": "Homeobox protein Nkx-2.4", "gene_name": "NKX2-4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSLSPKHTTPFSVSDILSPIEETYKKFSGAMDGAPPGLGAPLGAAAAYRAPPPGPSSQAATVAGMQPSHAMAGHNAAAAAAAAAAAAAAAATYHMPPGVSQFPHGAMGSYCNGGLGNMGELPAYTDGMRGGAATGWYGANPDPRYSSISRFMGPSAGVNVAGMGSLTGIADAAKSLGPLHAAAAAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQEGGLGPPPPPPPSPRRVAVPVLVKDGKPCQNGASTPTPGQAGPQPPAPTPAPELEELSPSPPALHGPGGGLAALDAAAGEYSGGVLGANLLYGRTW", "length": 354 }, "evidence": [ { "id": "F1MKX5", "url": "https://omabrowser.org/oma/group/F1MKX5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "F1MKX5", "url": "https://www.uniprot.org/uniprotkb/F1MKX5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "F1MKX5", "url": "https://www.uniprot.org/uniprotkb/F1MKX5" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MKX5", "url": "https://www.uniprot.org/uniprotkb/F1MKX5" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "F1MKX5", "url": "https://www.uniprot.org/uniprotkb/F1MKX5" } ], "pmid": "" }, { "name": "animal organ development", "id": "GO:0048513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048513", "evidence": [ { "database": "UniProtKB", "id": "F1MKX5", "url": "https://www.uniprot.org/uniprotkb/F1MKX5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "F1MKX5", "url": "https://www.uniprot.org/uniprotkb/F1MKX5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "F1MKX5", "url": "https://www.uniprot.org/uniprotkb/F1MKX5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MKX5-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 347, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MKX5-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MKX5" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MKX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKX5" }, { "id": "PS50071", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50071" }, { "id": "PRU00108", "database": "PROSITE", "url": "https://prosite.expasy.org/PRU00108" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Homeobox", "eco_id": "ECO_0000259", "start_pos": 184, "end_pos": 244, "start_aa": "Ala", "end_aa": "Gln", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 290, 301 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MKY1-1", "uniprot_ac": "F1MKY1", "uniprot_id": "F1MKY1_BOVIN", "mass": { "chemical_mass": 80186.0, "monoisotopic_mass": 80186.0 }, "refseq": { "ac": "NP_001069000", "name": "angiogenic factor with G patch and FHA domains 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069000" }, "gene_names": [ { "name": "AGGF1", "type": "recommended", "evidence": [ { "id": "F1MKY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY1" } ] }, { "name": "AGGF1", "type": "synonym", "evidence": [ { "id": "NP_001069000", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069000" } ] }, { "name": "VG5Q", "type": "synonym", "evidence": [ { "id": "NP_001069000", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069000" } ] } ], "protein_names": [ { "name": "Angiogenic factor with G patch and FHA domains 1", "type": "recommended", "evidence": [ { "id": "F1MKY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY1/entry#names_and_taxonomy" } ] }, { "name": "Angiogenic factor VG5Q", "type": "synonym", "evidence": [ { "id": "F1MKY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY1/entry#names_and_taxonomy" } ] }, { "name": "angiogenic factor with G patch and FHA domains 1", "type": "synonym", "evidence": [ { "id": "NP_001069000", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069000" } ] } ], "function": [ { "annotation": "Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.", "evidence": [ { "database": "UniProtKB", "id": "F1MKY1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1#function" }, { "database": "UniProtKB", "id": "ARBA00053945", "url": "https://www.uniprot.org/uniprotkb/ARBA00053945#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MKY1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "AGGF1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1", "locus": { "chromosome": "10", "start_pos": 8223030, "end_pos": 8176687, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000034823", "url": "https://www.ensembl.org/id/ENSBTAG00000034823" } ] } } ], "crossref": [ { "id": "F1MKY1", "url": "https://alphafold.ebi.ac.uk/entry/F1MKY1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034823", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034823", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16164", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16164", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22686", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22686", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "511650", "url": "https://www.ncbi.nlm.nih.gov/gene/511650", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000253", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000253", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000467", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000467", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008984", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008984", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035624", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035624", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053027", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053027", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:511650", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511650", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QLHKTHA", "url": "https://omabrowser.org/oma/group/QLHKTHA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MKY1", "url": "https://www.orthodb.org/?gene=F1MKY1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23106", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23106", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23106:SF24", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23106:SF24", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00498", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00498", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01585", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01585", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF17780", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17780", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001069000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069000", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MKY1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKY1-1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASEAPPPSLSPSPPPSPEPELAQLRRKVETLERELRSCKRQVREIEKLLHHTERLYQSAESNNQELRTQVEELSKILHCGRNEDNKKSDVEVQTENHPPWSISDYYYQTYYNEVNLPNKASELSVQEDKDIEASTFSSKDQSRIENDTYAGTDITENLGQEDHFASNSQEPASALATENASLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFHSRVDLQPYQTSGTKQSKDKKLKKKRKDPASSTTNEEKNLNSEDQKTSSIEHISCSEGEDFANVKKKAKVDIHYKNSPPKYTVPVSAKTVESPLNENIYNSASFKDEKIIDTDSEPEEGEITDSQTEDSSDEDLTSEDNATAEDTEDEDEEKIWPPCIRVIVIRSPVLQTGSLFIITAVNPATIGREKDMEHTLRIPEVGVSKFHAEIYFDHDLQSYVLVDQGSQNGTVVNGKQILQPKTKCDPYVLEHGDEVKIGETVLSFHIHPGSDTCDGCEPGQVRAHLRLDKKDELFVGPALSKEEKELERRKELKKIRVKYGLQNTDYEDEKTLKNPKYKDRAGKRREQIGSEGTFQRDDAPASVHSEITDSNKGRKMLEKMGWKKGEGLGKDGGGMKTPIQLQLRRTHAGLGTGKPSSIEDVQLLQNKSKKNWEKARERFAENFPEAKSQKDAPGTVPWVKGAVE", "length": 712, "header": "tr|F1MKY1-1|F1MKY1_BOVIN Isoform 1 of Angiogenic factor with G patch and FHA domains 1 OS=Bos taurus OX=9913 GN=AGGF1 PE=4 SV=1 CANONICAL=F1MKY1-1" }, "isoforms": [ { "isoform_ac": "F1MKY1-1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1/entry", "sequence": { "sequence": "MASEAPPPSLSPSPPPSPEPELAQLRRKVETLERELRSCKRQVREIEKLLHHTERLYQSAESNNQELRTQVEELSKILHCGRNEDNKKSDVEVQTENHPPWSISDYYYQTYYNEVNLPNKASELSVQEDKDIEASTFSSKDQSRIENDTYAGTDITENLGQEDHFASNSQEPASALATENASLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFHSRVDLQPYQTSGTKQSKDKKLKKKRKDPASSTTNEEKNLNSEDQKTSSIEHISCSEGEDFANVKKKAKVDIHYKNSPPKYTVPVSAKTVESPLNENIYNSASFKDEKIIDTDSEPEEGEITDSQTEDSSDEDLTSEDNATAEDTEDEDEEKIWPPCIRVIVIRSPVLQTGSLFIITAVNPATIGREKDMEHTLRIPEVGVSKFHAEIYFDHDLQSYVLVDQGSQNGTVVNGKQILQPKTKCDPYVLEHGDEVKIGETVLSFHIHPGSDTCDGCEPGQVRAHLRLDKKDELFVGPALSKEEKELERRKELKKIRVKYGLQNTDYEDEKTLKNPKYKDRAGKRREQIGSEGTFQRDDAPASVHSEITDSNKGRKMLEKMGWKKGEGLGKDGGGMKTPIQLQLRRTHAGLGTGKPSSIEDVQLLQNKSKKNWEKARERFAENFPEAKSQKDAPGTVPWVKGAVE", "length": 712, "header": "tr|F1MKY1-1|F1MKY1_BOVIN Isoform 1 of Angiogenic factor with G patch and FHA domains 1 OS=Bos taurus OX=9913 GN=AGGF1 PE=4 SV=1 CANONICAL=F1MKY1-1" }, "locus": { "chromosome": "10", "start_pos": 8221734, "end_pos": 8177035, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049280.4", "url": "https://www.ensembl.org/id/ENSBTAT00000049280.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046195.2", "url": "https://www.ensembl.org/id/ENSBTAP00000046195.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:511650", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:511650", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K295-1", "protein_name": "Angiogenic factor with G patch and FHA domains 1", "gene_name": "Aggf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASEAPSPPPASPEPELAQLRRKVEKLERELRSCKRQVREVEKLLHHTERLYQNAESNNQELRTQVEELSKILRCGKNEDNQKSDVEVQTESHAAWSSSDYYYQTYYKDDNLPSKETELCAQQSPYVQASALDSKAESRIDSESYSTEMAESVNHRHEDHFTSDSQESASALAEGSALEGSSLAESLRAAAEAAVSQTSFTYDESTGLYFDHSTGFYYDSENQLYYDASTGIYYYCDVESGRYQFHSRVHLQPYQTSSTKPSKDKKLKKRRKEPGFWTATEEKDLSSEDQKVCSIEYINCSEDENSGNVKKKARTDTSHKSSPLPLAGAVSGDMVESPGDEASASLKDERERASESEPEEGEITDSQSECSYDGDPSSGDRQSSEESDDEDDEEKIWPPCIRVIVIRSPVLQMGSLFIITAVSPATIGREKDMEHTVRIPEVAVSKFHAEVYFDHDLQSYVLVDQGSQNGTIVNGKQILQPKTKCDPYILEHGDEVKIGETVLSFHIHPGSETCDGCEPGQVRAHLRLDKKDEPLVGPALSKEEKELERRKALKKIRVKYGLQNTDYEDEKALKNPKYKDRAGKRREQVGSEGTFQRDDAPASVHSEITDSNKGRKMLEKMGWKKGEGLGKDGGGMKTPIQLQLRRTHAGLGTGKPSSIDDVHFLQNKSKKNWDKARERFAENFTEKKACKEAPGPIPWVTGTAE", "length": 705 }, "evidence": [ { "id": "F1MKY1", "url": "https://omabrowser.org/oma/group/F1MKY1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1NWU4-1", "protein_name": "Angiogenic factor with G patch and FHA domains 1", "gene_name": "AGGF1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MASPPHGEMRALRDQVAALEADLAACRGQLERAQRRLRRTERLYREARDGSEALRRQVEELTKEIHSRKQKDTSSVEVQTEDYAWSQADYYYYENYYNHTDAQDYASELSVQHNHGTEGTEHDFTEESQMDTNIPSRVNSTEVAEGGGEENLIQNSQEAEDASAPEGSLAESLRAAAEAAVSQTGFIYDENTGLYYDHSTGFYYNSENQLYYDPATGIYYYCDVESGRYQFHSRVDLQSYQASGSQHAKDKKGKKKRKDPEWSTANEYKDMDTEEQKSSNNLNCFSTTEQVSSTEEEESLNARKKTKMDAKIRNNLTAKESIATDSMNSHSHKSTPDTAAYTDDNRIVDTESEPEEGEITDSEREPYSSTDEVTSEETNDSEDSENEDEEKIWPPCIRVIVIRSPVLQTGSLYIITAVKPATIGREKDVGHTLQIPEVGVSKFHAEVYFDHDLQNYVLVDQGSQNGTVVNGNQILQPKTKCDPYILEHGDEVKIGETVLSFHIHPGSDTCDGCEPGQVRAHLRLDKKKESSVCPALSKEERELVRRKALKQIRVKYGLQNTEYEDNKAVKNPKYKDRAGKRRETIGSEGTFQRGDTPASVHIEISDSNKGHKMLEKMGWKKGEGLGKDGGGMKDPIHLQLHKMHAGLGTSRPTSIEDIQIVPSKNKKNWEKARERFAENFQEPKSQKDTPKSTPWVRGTVE", "length": 701 }, "evidence": [ { "id": "F1MKY1", "url": "https://omabrowser.org/oma/group/F1MKY1/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "Q7TN31-1", "protein_name": "Angiogenic factor with G patch and FHA domains 1", "gene_name": "Aggf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASEAPSPPSPSPPPPASPEPELAQLRRKVEKLERELRSCRRQVREVEKLLQHTERLYRNAESDNQELRTQVEELSKILHCGKNEDNPKSDVEVQTESQAPWAISDYYYQTCYNDDSLPSKETELCVQQSQCAQASALDPQDESHIDSGSYAGADATEGVSHRQEDAVTSDSQESVSALAEGPALEGSSLAESLRAAAEAAVSQTGFTYDESTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFHSRVDLQPYQTSSTKPNRERRLKKRRKEPGFYTANEEKDLSSEDQKVCSVEYINCSEDEHSGNVKKKARTDTSHKSSPLQLTVAVSGDTVESPGDDNSASSKDERIGESESEPEEGEITDSQSEKSYDGDSSSGDRETSEESDDEDEERIWPPCIRVIVIRSPVLQMGSLFIITAVSPATIGREKDMEHTVRIPEVAVSKFHAEVYFDHDLQSYVLVDQGSQNGTIVNGKQILQPKTKCDPYVLEHGDEVKIGETVLSFHIHPGSETCDGCEPGQVRAHLRLDRKDEPLVGPALSKEEKELERRKALKKIRVKYGLQNTDYEAEKALKNPKYKDRAGKRREQVGSEGTFQRDDAPASVHSEITDSNKGRKMLEKMGWKRGEGLGKDGGGMKTPIQLQLRRTHAGLGTGKLSSIDDVHLIQNKSKKHWDKARERFAETFTENKPRKETPGAVPWVTGTAE", "length": 711 }, "evidence": [ { "id": "F1MKY1", "url": "https://omabrowser.org/oma/group/F1MKY1/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N302-1", "protein_name": "Angiogenic factor with G patch and FHA domains 1", "gene_name": "AGGF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVENDAYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKKKRKDPDSSATNEEKDLNSEDQKAFSVEHTSCNEEENFANMKKKAKIGIHHKNSPPKVTVPTSGNTIESPLHENISNSTSFKDEKIMETDSEPEEGEITDSQTEDSYDEAITSEGNVTAEDSEDEDEDKIWPPCIRVIVIRSPVLQIGSLFIITAVNPATIGREKDMEHTLRIPEVGVSKFHAEIYFDHDLQSYVLVDQGSQNGTIVNGKQILQPKTKCDPYVLEHGDEVKIGETVLSFHIHPGSDTCDGCEPGQVRAHLRLDKKDESFVGPTLSKEEKELERRKELKKIRVKYGLQNTEYEDEKTLKNPKYKDRAGKRREQVGSEGTFQRDDAPASVHSEITDSNKGRKMLEKMGWKKGEGLGKDGGGMKTPIQLQLRRTHAGLGTGKPSSFEDVHLLQNKNKKNWDKARERFTENFPETKPQKDDPGTMPWVKGTLE", "length": 714 }, "evidence": [ { "id": "F1MKY1", "url": "https://omabrowser.org/oma/group/F1MKY1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "F1MKY1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1" } ], "pmid": "" }, { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1MKY1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "F1MKY1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1" } ], "pmid": "" }, { "name": "positive regulation of angiogenesis", "id": "GO:0045766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045766", "evidence": [ { "database": "UniProtKB", "id": "F1MKY1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell proliferation", "id": "GO:0001938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001938", "evidence": [ { "database": "UniProtKB", "id": "F1MKY1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "F1MKY1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "F1MKY1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "F1MKY1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1" } ], "pmid": "" }, { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "F1MKY1", "url": "https://www.uniprot.org/uniprotkb/F1MKY1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" }, { "start_pos": 389, "end_pos": 391, "annotation": "n_glycosylation_sequon" }, { "start_pos": 476, "end_pos": 478, "annotation": "n_glycosylation_sequon" }, { "start_pos": 674, "end_pos": 676, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MKY1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 712, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MKY1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MKY1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MKY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY1" }, { "id": "PS50006", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50006" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "FHA", "eco_id": "ECO_0000259", "start_pos": 432, "end_pos": 485, "start_aa": "Ala", "end_aa": "Ile", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MKY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY1" }, { "id": "PS50174", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50174" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "G-patch", "eco_id": "ECO_0000259", "start_pos": 617, "end_pos": 663, "start_aa": "Asp", "end_aa": "Pro", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 147, "end_pos": 149 }, { "start_pos": 180, "end_pos": 182 }, { "start_pos": 389, "end_pos": 391 }, { "start_pos": 476, "end_pos": 478 }, { "start_pos": 674, "end_pos": 676 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MKY3-1", "uniprot_ac": "F1MKY3", "uniprot_id": "F1MKY3_BOVIN", "mass": { "chemical_mass": 66683.0, "monoisotopic_mass": 66683.0 }, "refseq": { "ac": "XP_024838967", "name": "sushi domain-containing protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838967" }, "gene_names": [ { "name": "SUSD5", "type": "recommended", "evidence": [ { "id": "F1MKY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY3" } ] }, { "name": "SUSD5", "type": "synonym", "evidence": [ { "id": "XP_024838967", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838967" } ] } ], "protein_names": [ { "name": "Sushi domain containing 5", "type": "synonym", "evidence": [ { "id": "F1MKY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY3/entry#names_and_taxonomy" } ] }, { "name": "sushi domain-containing protein 5", "type": "synonym", "evidence": [ { "id": "XP_024838967", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838967" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MKY3", "url": "https://www.uniprot.org/uniprotkb/F1MKY3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SUSD5", "url": "https://www.uniprot.org/uniprotkb/F1MKY3", "locus": { "chromosome": "22", "start_pos": 7499864, "end_pos": 7542105, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005327", "url": "https://www.ensembl.org/id/ENSBTAG00000005327" } ] } } ], "crossref": [ { "id": "F1MKY3", "url": "https://alphafold.ebi.ac.uk/entry/F1MKY3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005327", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005327", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "524663", "url": "https://www.ncbi.nlm.nih.gov/gene/524663", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000436", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000436", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000538", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000538", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035976", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035976", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR053298", "url": "https://www.ebi.ac.uk/interpro/entry/IPR053298", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524663", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524663", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YGQVQAC", "url": "https://omabrowser.org/oma/group/YGQVQAC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MKY3", "url": "https://www.orthodb.org/?gene=F1MKY3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32493", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32493", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32493:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32493:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00084", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00084", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00193", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_024838967", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838967", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MKY3", "url": "https://www.uniprot.org/uniprotkb/F1MKY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKY3-1", "url": "https://www.uniprot.org/uniprotkb/F1MKY3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAEGPGPGARLWAAALLLLGLPRLSTPANGKLFVLESQNGSQGLALEAARLSCRSRGAHLVSADELRRVVQDCALAVCTTGWLADGTLGTTVCNERRGEQQTMRAVDVRVKSSPVPGGTYNALCIKDEEKPCGDPPSFPHTILQGRTGLEMGDELLYVCAPGHVTGQRETAFTLLCDSCGEWYGLVQACGKDEAEVHIDYEDNFPDDRSVSFRELMEDSHTEAEEDRSQGEPSEEAPKQDRLVSMPVASEDRAQDTSFVPTTGLLGAGSPVPTELPGSQGSGKDMLWSPAGTFHKPEWEKAMDEDAKKHLPAGDHHRDSTLAPGEPETKVIYHSTDGPSGPSVGRNDSRAGDAMVSSSDESWLDGYPVTDGAWRQTEAGAEEDEEEEDKGDGSVGLEESMLITPSQPALAERKRSRGTTLTPSEDVTSLLPSQTLDGEALALRPTNVSETEGPSKGAGDLTGNQSTVPWRYATEKPPSSTLPYELTSSTLKTETTTVQKTPNLTPSTVAAATQTPLETTAPAVQDTFPYLLSEDFLGQEVPGPGASEELLPTLEPCAGGKCPSLGRGPIIATIVTVLCLLLFLAGVGGVWGYRSCQHKSSVYKLNVGQRQARHYHQQIEMEKV", "length": 624, "header": "tr|F1MKY3-1|F1MKY3_BOVIN Isoform 1 of Sushi domain containing 5 OS=Bos taurus OX=9913 GN=SUSD5 PE=4 SV=3 CANONICAL=F1MKY3-1" }, "isoforms": [ { "isoform_ac": "F1MKY3-1", "url": "https://www.uniprot.org/uniprotkb/F1MKY3/entry", "sequence": { "sequence": "MAAEGPGPGARLWAAALLLLGLPRLSTPANGKLFVLESQNGSQGLALEAARLSCRSRGAHLVSADELRRVVQDCALAVCTTGWLADGTLGTTVCNERRGEQQTMRAVDVRVKSSPVPGGTYNALCIKDEEKPCGDPPSFPHTILQGRTGLEMGDELLYVCAPGHVTGQRETAFTLLCDSCGEWYGLVQACGKDEAEVHIDYEDNFPDDRSVSFRELMEDSHTEAEEDRSQGEPSEEAPKQDRLVSMPVASEDRAQDTSFVPTTGLLGAGSPVPTELPGSQGSGKDMLWSPAGTFHKPEWEKAMDEDAKKHLPAGDHHRDSTLAPGEPETKVIYHSTDGPSGPSVGRNDSRAGDAMVSSSDESWLDGYPVTDGAWRQTEAGAEEDEEEEDKGDGSVGLEESMLITPSQPALAERKRSRGTTLTPSEDVTSLLPSQTLDGEALALRPTNVSETEGPSKGAGDLTGNQSTVPWRYATEKPPSSTLPYELTSSTLKTETTTVQKTPNLTPSTVAAATQTPLETTAPAVQDTFPYLLSEDFLGQEVPGPGASEELLPTLEPCAGGKCPSLGRGPIIATIVTVLCLLLFLAGVGGVWGYRSCQHKSSVYKLNVGQRQARHYHQQIEMEKV", "length": 624, "header": "tr|F1MKY3-1|F1MKY3_BOVIN Isoform 1 of Sushi domain containing 5 OS=Bos taurus OX=9913 GN=SUSD5 PE=4 SV=3 CANONICAL=F1MKY3-1" }, "locus": { "chromosome": "22", "start_pos": 7541906, "end_pos": 7499867, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000049275.5", "url": "https://www.ensembl.org/id/ENSBTAT00000049275.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000046191.4", "url": "https://www.ensembl.org/id/ENSBTAP00000046191.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:524663", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524663", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZNE4-1", "protein_name": "Sushi domain containing 5", "gene_name": "SUSD5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAERPSSGAWFWAAALLLLGLQRLSVRADGKFFVLESQNGSRGLDLEAAWLSCKSRGAHLASADELRRVVQDCALAVCTTGWLADGNLGTTVCSKGSGEQQIRRAVDMRIESNVVPGSTYNALCIKDEEKPCGDPPSFPHTVLQGRTGLEMGDELLYVCAPGHVTGRRETAFTLLCNSCGEWYGLVQACGKDEAEAHIDYEDNFPDDRSVSFRELMEDSRTEVEEDGGPGDASEEAPKQDRLVSGSVGREDIALDKAFVPTTGLPSAGSSVPTDLPGSRRNQKYLFWFPAEPFHKPALEKEMDDDTKEQFPAGDHQSGTTLAPGEPETRATYGSRGGPSRPFVGRNDSKAVGAVVSGSDESWLDGYPVTDGTWRKPEADEEDEEDKGDGSVGLEESILVKTSPPILVDVKEPMSTTLPPAEDITHGSGLPSQTLDVEALALRPVNVSDTEGPSEGDGDLARYSSTVPWRDTTEKSPMSTLANELPSSTLETGTTAVQKTPNHIPSTATAATQTPVETAAPEVKDTFPYLLSEDFLGQEGAPGPGASEELFPTLEPCAGDKCPGLSRGPIIATIVTVLCLLLFLAGVGAVWGYRKCQHKSSVYKLNAGQRRHYHQQIEMEKV", "length": 622 }, "evidence": [ { "id": "F1MKY3", "url": "https://omabrowser.org/oma/group/F1MKY3/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V0Z160-1", "protein_name": "Sushi domain containing 5", "gene_name": "SUSD5", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALGSRRSSLTFARAVGPVFFILQIISVRADGKVFALQSKNNSQGLDLAEAEKACVDLSARLATAEELKRAVLDCSFIGCTTGWLADGTAGTIICRKTGSKQQSVKAIDVKIETDPFVNDQYDAFCVKDEDKPCGDPPSFPHTILHGHTGFEMGDELLYVCAQGYVMGNKETAFTLLCDSCGEWYGQVQACVKDETEAHIDYEDNFPDDRSIPIAENEHANGKEEIEQEQLSFSKKSEEGRTGSTKGVTQDIDTSEKGSRAPTESPVSLLSQKNLFWFPSEAFSEPESEKGTDDSTKAHFSEGDNHIGVKTVYDEPGAKMFYDSEDFPIGPILTANDTKEEIDAVPITDESWLDGYPVTQEVVEDDEEEGDKVDGSMGTEEDIILTTDQPNHVEVRKLGDGSPAPEEGLTQIVAATTSIDDERVKETPVPLTSVSGLEDLSVSRGYDDAAWDHPTTALETVTQEPVTTVLLDITSLRTSVSETSVMASPFDHTTEEEAKGTTAYPAQVATTAPAPDILTGTSSPELDEQENLTQGLGEKPVPTSEPCEGEDCPRSSKGAVIAVIVILLCLLLAAAVLAVWFFKKRQQKNSVYKLNGRCQPRHHCYHHYHHQHIEMQKV", "length": 618 }, "evidence": [ { "id": "F1MKY3", "url": "https://omabrowser.org/oma/group/F1MKY3/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZSC1-1", "protein_name": "Sushi domain containing 5", "gene_name": "Susd5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAGPQWPAPRSLPALCAALLLLALQPPPVRAEGKLFVLDSQNGSQGLDLETARQSCKSRGAHLVSAGELKRVVQDCASAVCTTGWLADGTLGTTVCSKGSGEQPVLRAIDVTIDSHPVPGAKYNALCIKDEERPCGDPPSFPHTILQGRTGLEMGDELLYVCVPGSVTGHRETAFTLLCNSCGEWYGLVQACGKDEAEAHIDYEENFPDDRSVSFRELMEDSRAEGEKEKAQEDASDETPKQDRLVFTSVSKENIAQEKAFVPTTGLPGAGSSFHTDWPRSRLHRKYSLWFPAETFHKSELEKDVDDETKEPLPARDTHSDEKPAPEESETRLVYATTYSPSEPFADRNDSKAEDIGVSSSDDSWLDGYPVTDGAWRKVEAGQEDDEDKGDGSVGPDDSVLMSPDQPIKNVTVISSESVIYSSISPSQMLDVEALVPGPINVSETERPHTGDADLTNYQSTIPRRVTTQQSPMATSPSELTTSTTQETVLTTLQPTHKHSPSSNVEATQPPAEVTAPEVQDNFPYLLSEDFLGQEGPGPGASEERLLPTLAPCVGDECPSFRKGPVIATIVTVLCLLFLLAVSGAVWGYRRCQHKSSVYKLNVGQRQARHYHQQIEMEKV", "length": 621 }, "evidence": [ { "id": "F1MKY3", "url": "https://omabrowser.org/oma/group/F1MKY3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "G3UW60-1", "protein_name": "Sushi domain containing 5", "gene_name": "Susd5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAGPLWPAPGSLPALCAALLLLALQPPPVRAEGKLFMLGSQNGSQGLDLEAARLSCRSRGAHLVSAAELKRVVRDCASAVCTTGWLADGTLGTTVCSKGSGEQPVSRAVDVRIDSHPVPGAKYNALCIKDEERPCGDPPSFPHTILQGRTGLEMGDELLYLCAPGSVPGHRETAFTLLCNSCGEWYGLVQACGKDEAEAHIDYEENFPDDRSVSFRELMEDSRAEGEKEKAQEDASDETPKQDRLVFTSVSKENIAQVKAFVPTTGSPGAGGSVRTDWPRSRLHRKYSLWFPAETFHKPELGKDEGDETKEPLPARDNHSEEKPAPEESETRLVYATTYSPSEPFVDRNDSKAEDPGVSSSDDSWLDGYPVTDGAWRKVEAGQEDDEDKGDGSVGPDESGLTTPDKEPENVTVTPSESVIHSSISPSQMLDVEALVPGPINVSETESSHTRDVDSTSSQSTIPRRVTTQPSPKVTSPHELASSTQETVTTTLQPTHKRTPSTDVEATQPPAGVTAPEVQDNFPYLLSEDFLGQEGPGPGASEKFLPTSAPCVGDECPSFRKGPVIATVVTVLCLLLLLVVAGAVWGYRRCQHKSSVYKLNVGQRQARHYQQQIEMEKV", "length": 619 }, "evidence": [ { "id": "F1MKY3", "url": "https://omabrowser.org/oma/group/F1MKY3/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O60279-1", "protein_name": "Sushi domain-containing protein 5", "gene_name": "SUSD5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTAEGPSPPARWHRRLPGLWAAALLLLGLPRLSVRADGKFFVLESQNGSQGLQLEAARLSCKSRGAHLASADELRRVVQDCSFAVCTTGWLADGTLGTTVCSKGSGEQQIMRAVDVRIESNPVPGGTYSALCIKDEEKPCGDPPSFPHTILQGRTGLEMGDELLYVCAPGHIMGHRETAFTLLCNSCGEWYGLVQACGKDEAEAHIDYEDNFPDDRSVSFRELMEDSRTEADEDRGQGDSSEEAPKQDRLVSISVGRENIARDKVFVPTTGLPGAGSSVPADSPGSRLLQKHLFWFPAEAFHKPGLEKEVDDDTKKQFSAGDNHSGVKLVPGEPETKVIYGNTDGPSGPFVGKNDSKAGDPVVSSSDESWLDGYPVTEGAWRKTEAEEEEDGDRGDGSVGLDENVLVTPDQPILVEVKKPKSSTLTPSEGMTHSSVLPSQMLDVEALALRPVNASETEGIGDGDLTKYQSTLPWRFITEESPMATLSYELTSSTLEILTVNTVKQTPNHIPSTIMATTQPPVETTVPEIQDSFPYLLSEDFFGQEGPGPGASEELHPTLESCVGDGCPGLSRGPVIATIVTVLCLLLLLAGVGMVWGYRKCQHKSSVYKLNVGQRQARHYHQQIEMEKV", "length": 629 }, "evidence": [ { "id": "F1MKY3", "url": "https://omabrowser.org/oma/group/F1MKY3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1MKY3", "url": "https://www.uniprot.org/uniprotkb/F1MKY3" } ], "pmid": "" }, { "name": "Notch signaling pathway", "id": "GO:0007219", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007219", "evidence": [ { "database": "UniProtKB", "id": "F1MKY3", "url": "https://www.uniprot.org/uniprotkb/F1MKY3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "hyaluronic acid binding", "id": "GO:0005540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005540", "evidence": [ { "database": "UniProtKB", "id": "F1MKY3", "url": "https://www.uniprot.org/uniprotkb/F1MKY3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 40, "end_pos": 42, "annotation": "n_glycosylation_sequon" }, { "start_pos": 447, "end_pos": 449, "annotation": "n_glycosylation_sequon" }, { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" }, { "start_pos": 503, "end_pos": 505, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MKY3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 624, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MKY3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MKY3" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MKY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY3" }, { "id": "PS50963", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50963" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Link", "eco_id": "ECO_0000259", "start_pos": 32, "end_pos": 127, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MKY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY3" }, { "id": "PS50923", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50923" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sushi", "eco_id": "ECO_0000259", "start_pos": 131, "end_pos": 192, "start_aa": "Lys", "end_aa": "Lys", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 347, "end_pos": 349 }, { "start_pos": 40, "end_pos": 42 }, { "start_pos": 447, "end_pos": 449 }, { "start_pos": 464, "end_pos": 466 }, { "start_pos": 503, "end_pos": 505 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", 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}, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MKY9-1", "uniprot_ac": "F1MKY9", "uniprot_id": "F1MKY9_BOVIN", "mass": { "chemical_mass": 228525.0, "monoisotopic_mass": 228525.0 }, "refseq": { "ac": "NP_001179177", "name": "alpha-protein kinase 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179177" }, "gene_names": [ { "name": "ALPK2", "type": "recommended", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "name": "ALPK2", "type": "synonym", "evidence": [ { "id": "NP_001179177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179177" } ] } ], "protein_names": [ { "name": "Alpha-protein kinase 2", "type": "recommended", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9/entry#names_and_taxonomy" } ] }, { "name": "2.7.11.1", "type": "synonym", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9/entry#names_and_taxonomy" } ] }, { "name": "Heart alpha-protein kinase", "type": "synonym", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9/entry#names_and_taxonomy" } ] }, { "name": "alpha-protein kinase 2", "type": "synonym", "evidence": [ { "id": "NP_001179177", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179177" } ] } ], "function": [ { "annotation": "Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling.", "evidence": [ { "database": "UniProtKB", "id": "F1MKY9", "url": "https://www.uniprot.org/uniprotkb/F1MKY9#function" }, { "database": "UniProtKB", "id": "ARBA00059647", "url": "https://www.uniprot.org/uniprotkb/ARBA00059647#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MKY9", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "ALPK2", "url": "https://www.uniprot.org/uniprotkb/F1MKY9", "locus": { "chromosome": "24", "start_pos": 57612080, "end_pos": 57740561, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000014284", "url": "https://www.ensembl.org/id/ENSBTAG00000014284" } ] } } ], "crossref": [ { "id": "ENSBTAG00000014284", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000014284", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16974", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16974", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "510218", "url": "https://www.ncbi.nlm.nih.gov/gene/510218", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004166", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004166", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:510218", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510218", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MKY9", "url": "https://www.orthodb.org/?gene=F1MKY9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47091", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47091", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47091:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47091:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02816", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02816", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "NP_001179177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179177", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17989", "url": "https://www.rhea-db.org/rhea/17989", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46608", "url": "https://www.rhea-db.org/rhea/46608", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MKY9", "url": "https://www.uniprot.org/uniprotkb/F1MKY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKY9-1", "url": "https://www.uniprot.org/uniprotkb/F1MKY9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVSRTSQHLTVEFETGQPKPEVTWYKNGRTIDECGSVSSYEFFENQYVHVLHLYCCTQNDTAVYQVSARNCFGMICCSASIEVQCPTEDQPLSPNPKDDGHTGWKHDTETYEQESPNHTDEKEHPYKEGEGIASGPPTSADAPSSKSSGAHSLQVSADRDPGASGSDNPLAVKDTRQTEEAGGAANTEGVADGLRFPSSSDAPDKQDVCGHRAVHSEVPRLTDGALDPEGPNEEALNSSHQNARVQKYISFGPALTRADSSAPPGTRPVSPPASSTDSDSDYELCPEITLTCAEEFSDDDLEYLECSDVMTDYSNAIWQRNLQGTERVFLLESDDEEMEFSECSLGGCARFFSELGCRPPVSDDTGPMDATAGLCGHHSPPQEVGGRSSRASTHRASSLQEGMPLPLGLQQDGPAMVTDLGRYKPPAALEAAEDGYPGIQGETRDSHQAGKEFSGDKLLNMDKAVAGTEGKHLSGESGQPGMSRCLETRAERRVGGKDGWSQRGSEKPARTWRPGIKGKAKRLNSSLEERTAEASLDRLCPKGPVKHPLTPSDKRVSSHARAEGADLKPQLPAGGPEVPTQAEPEVKTLQAPPGLLSKEETLHFQREGVRVTDVFETCKVSGWSDHPQVQIQETVREQISLSHMPAFSEPTGEEPTFPGTTTESLPNLGGIDKESASLAKHPEVDGCTQGARHEENQGDNTLRRSGRDLGRVLSIPEASSEATSPCELLGPPPQPQAASASPEFAHTVPALETMCAAGPGDGVAVCGPERLEAGDQEACDIVGSPVGAPVGKHLPQEMCSLDLELAGQSKPPDLCPPDDKTLDVLSQTQGPEPPQTTCGSSGERTSPDSPLFISTFTWNISQKASKGATGEDLANIEGSASTSASIVKAGQERLSPSHSGDLEERWPPSPESSSSVWAIEGSDKNSSPGAPDSADIPAGHSPVTKFPREKPTTLIADVECSEVTGANSNTSALSVAPKGHPSKYLAVSVAGDSHAGGPEESSPRAPDGSASRLPSSVQLAHVFNGSTIKSSRELGPMAPSGPGIHVRVPQLPEGEGFGGSSPLQINNLSRKKSQARHTADTRTLEENFQEKGSETAERVQQGSSDDNSQETLPTTSVGQVETNLVPLDCSSASSTERRGQSSGTRVSVVAESPMKDDSQPLSQAPLLSNVLLDKSKERSPGCWEAGKKLKIITLEASVSETWPLGQLTDSGFKGMAAGLIPDRIRAIPDVLKAGAAVPKPGPSKTASACSPQVEYSSAIANNRKIHKREERAGCASWSCLSSQYLSQRRFLESSVDPVEGKKVCVTGLLPEAFRTGRKENANRVSQNRDENRLKRDRPAFFKQLLSCPNILESSVDPTDEMSVGWARVETPEPSESTLGAIAVENKPKGGHLDQRLEVQPAILQVPCAQQSGETPPSENGTNQNQGDCVGWEAGQSRRERAKGDMRSAILPVPGAVQGGEAMPGAHIRSQVQEDGERRSGGPGRSKSNGAALVSPALALSGGLARVNPPSVGVTTHSFTARSDDLCEEDSVEPRNHEHAFSDSEERRAMKSEWKQAPSSRGLTRGPFTSSPERRGIADFSRSHRIEEREIEETPAGETKPTGTSGSPAGPLASVSGVHASAKAPNMLLDPYQQGSTLGHGKKSGEEEKVGPVAAQASHPPPPAAMKSPEVKEKQKTPGSGHLAEGVKKKILSRVAALRLRLEEKEKVRRHSVFESPKPETSVSRTDEKGEPQRPPCQSEGRAPVLLKKIQAEMSPDHSGNVKLSCQFAEIHEDSTISWTKDSTSIAQVQRRAGDNSMVSLAILQASQKDQGLYYCCIKNSYGRVTAEFNLTAEVLKQLSSHPDVKVYEEIEFSQLIFREDFLRDSYFGGRLHGQIATEELHFGEGVHRRAFRSKVLRGLTPVFKPGHACVLKVHNAVAYGARNNEELIQRNYRLAAQECYVQNTARHYAQIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATEATGYKGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQDNSQKQKKPSIGRSKIQPGTTAVKKAASGSLAEKKS", "length": 2127, "header": "tr|F1MKY9-1|F1MKY9_BOVIN Isoform 1 of Alpha-protein kinase 2 OS=Bos taurus OX=9913 GN=ALPK2 PE=3 SV=2 CANONICAL=F1MKY9-1" }, "isoforms": [ { "isoform_ac": "F1MKY9-1", "url": "https://www.uniprot.org/uniprotkb/F1MKY9/entry", "sequence": { "sequence": "MVSRTSQHLTVEFETGQPKPEVTWYKNGRTIDECGSVSSYEFFENQYVHVLHLYCCTQNDTAVYQVSARNCFGMICCSASIEVQCPTEDQPLSPNPKDDGHTGWKHDTETYEQESPNHTDEKEHPYKEGEGIASGPPTSADAPSSKSSGAHSLQVSADRDPGASGSDNPLAVKDTRQTEEAGGAANTEGVADGLRFPSSSDAPDKQDVCGHRAVHSEVPRLTDGALDPEGPNEEALNSSHQNARVQKYISFGPALTRADSSAPPGTRPVSPPASSTDSDSDYELCPEITLTCAEEFSDDDLEYLECSDVMTDYSNAIWQRNLQGTERVFLLESDDEEMEFSECSLGGCARFFSELGCRPPVSDDTGPMDATAGLCGHHSPPQEVGGRSSRASTHRASSLQEGMPLPLGLQQDGPAMVTDLGRYKPPAALEAAEDGYPGIQGETRDSHQAGKEFSGDKLLNMDKAVAGTEGKHLSGESGQPGMSRCLETRAERRVGGKDGWSQRGSEKPARTWRPGIKGKAKRLNSSLEERTAEASLDRLCPKGPVKHPLTPSDKRVSSHARAEGADLKPQLPAGGPEVPTQAEPEVKTLQAPPGLLSKEETLHFQREGVRVTDVFETCKVSGWSDHPQVQIQETVREQISLSHMPAFSEPTGEEPTFPGTTTESLPNLGGIDKESASLAKHPEVDGCTQGARHEENQGDNTLRRSGRDLGRVLSIPEASSEATSPCELLGPPPQPQAASASPEFAHTVPALETMCAAGPGDGVAVCGPERLEAGDQEACDIVGSPVGAPVGKHLPQEMCSLDLELAGQSKPPDLCPPDDKTLDVLSQTQGPEPPQTTCGSSGERTSPDSPLFISTFTWNISQKASKGATGEDLANIEGSASTSASIVKAGQERLSPSHSGDLEERWPPSPESSSSVWAIEGSDKNSSPGAPDSADIPAGHSPVTKFPREKPTTLIADVECSEVTGANSNTSALSVAPKGHPSKYLAVSVAGDSHAGGPEESSPRAPDGSASRLPSSVQLAHVFNGSTIKSSRELGPMAPSGPGIHVRVPQLPEGEGFGGSSPLQINNLSRKKSQARHTADTRTLEENFQEKGSETAERVQQGSSDDNSQETLPTTSVGQVETNLVPLDCSSASSTERRGQSSGTRVSVVAESPMKDDSQPLSQAPLLSNVLLDKSKERSPGCWEAGKKLKIITLEASVSETWPLGQLTDSGFKGMAAGLIPDRIRAIPDVLKAGAAVPKPGPSKTASACSPQVEYSSAIANNRKIHKREERAGCASWSCLSSQYLSQRRFLESSVDPVEGKKVCVTGLLPEAFRTGRKENANRVSQNRDENRLKRDRPAFFKQLLSCPNILESSVDPTDEMSVGWARVETPEPSESTLGAIAVENKPKGGHLDQRLEVQPAILQVPCAQQSGETPPSENGTNQNQGDCVGWEAGQSRRERAKGDMRSAILPVPGAVQGGEAMPGAHIRSQVQEDGERRSGGPGRSKSNGAALVSPALALSGGLARVNPPSVGVTTHSFTARSDDLCEEDSVEPRNHEHAFSDSEERRAMKSEWKQAPSSRGLTRGPFTSSPERRGIADFSRSHRIEEREIEETPAGETKPTGTSGSPAGPLASVSGVHASAKAPNMLLDPYQQGSTLGHGKKSGEEEKVGPVAAQASHPPPPAAMKSPEVKEKQKTPGSGHLAEGVKKKILSRVAALRLRLEEKEKVRRHSVFESPKPETSVSRTDEKGEPQRPPCQSEGRAPVLLKKIQAEMSPDHSGNVKLSCQFAEIHEDSTISWTKDSTSIAQVQRRAGDNSMVSLAILQASQKDQGLYYCCIKNSYGRVTAEFNLTAEVLKQLSSHPDVKVYEEIEFSQLIFREDFLRDSYFGGRLHGQIATEELHFGEGVHRRAFRSKVLRGLTPVFKPGHACVLKVHNAVAYGARNNEELIQRNYRLAAQECYVQNTARHYAQIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATEATGYKGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQDNSQKQKKPSIGRSKIQPGTTAVKKAASGSLAEKKS", "length": 2127, "header": "tr|F1MKY9-1|F1MKY9_BOVIN Isoform 1 of Alpha-protein kinase 2 OS=Bos taurus OX=9913 GN=ALPK2 PE=3 SV=2 CANONICAL=F1MKY9-1" }, "locus": { "chromosome": "24", "start_pos": 57740561, "end_pos": 57612639, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000018977.6", "url": "https://www.ensembl.org/id/ENSBTAT00000018977.6" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000018977.5", "url": "https://www.ensembl.org/id/ENSBTAP00000018977.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1358, "start_aa": "Thr", "end_pos": 1358, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1358", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "bta:510218", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:510218", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein serine/threonine kinase activity", "id": "GO:0004674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", "evidence": [ { "database": "UniProtKB", "id": "F1MKY9", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "F1MKY9", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "basolateral plasma membrane", "id": "GO:0016323", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016323", "evidence": [ { "database": "UniProtKB", "id": "F1MKY9", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "heart morphogenesis", "id": "GO:0003007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003007", "evidence": [ { "database": "UniProtKB", "id": "F1MKY9", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "F1MKY9", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ], "pmid": "" }, { "name": "cardiac muscle cell development", "id": "GO:0055013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055013", "evidence": [ { "database": "UniProtKB", "id": "F1MKY9", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ], "pmid": "" }, { "name": "establishment of cell polarity", "id": "GO:0030010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030010", "evidence": [ { "database": "UniProtKB", "id": "F1MKY9", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ], "pmid": "" }, { "name": "negative regulation of Wnt signaling pathway involved in heart development", "id": "GO:0003308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003308", "evidence": [ { "database": "UniProtKB", "id": "F1MKY9", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ], "pmid": "" }, { "name": "epicardium morphogenesis", "id": "GO:1905223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905223", "evidence": [ { "database": "UniProtKB", "id": "F1MKY9", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1024, "end_pos": 1026, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1067, "end_pos": 1069, "annotation": "n_glycosylation_sequon" }, { "start_pos": 117, "end_pos": 119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1419, "end_pos": 1421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1829, "end_pos": 1831, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2063, "end_pos": 2065, "annotation": "n_glycosylation_sequon" }, { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" }, { "start_pos": 524, "end_pos": 526, "annotation": "n_glycosylation_sequon" }, { "start_pos": 59, "end_pos": 61, "annotation": "n_glycosylation_sequon" }, { "start_pos": 859, "end_pos": 861, "annotation": "n_glycosylation_sequon" }, { "start_pos": 925, "end_pos": 927, "annotation": "n_glycosylation_sequon" }, { "start_pos": 969, "end_pos": 971, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17989", "name": "", "equation": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0A3Q1MLK5-1", "A0AAF6Z257-1", "F6RPH3-1", "F1MC27-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "F1N332-1", "A7MB74-1", "A0AAA9RW51-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A1A4I4-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "Q3SWY6-1", "A0AAA9T5C9-1", "A7E3S4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P32871-1", "P35508-1", "P67827-1", "P04409-1", "P05126-1", "P05128-1", "P46196-1", "H2XJE9-1", "Q0VD22-1", "Q2KJG8-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "Q2YDN8-1", "A0AAA9SK35-1", "A0AAA9RSJ2-1", "A0AAA9T7I8-1", "Q3T0P6-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "F6PN06-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9RTJ4-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0AAA9TCI9-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "E1BEI6-1", "A0A3Q1M1Z0-1", "F1MYM3-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1MI36-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0A3Q1NFM1-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "E1BEW4-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "Q5E9Y9-1", "A0ABI0NMT8-1", "A0ABI0NRQ5-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "17989", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17989" } ] }, { "id": "46608", "name": "", "equation": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "G5E5K2-1", "V6F977-1", "A0A3Q1MRW3-1", "A0A3Q1N860-1", "E1BI01-1", "F6RG88-1", "A0AAA9T8T9-1", "A0AAA9U1R3-1", "A7E3X2-1", "A0AAA9U1M9-1", "E1B754-1", "A0AAA9T7L6-1", "A0A3Q1M9F0-1", "A0ABI0P3P6-1", "E1BNH0-1", "A0AAA9TMV7-1", "A0AAA9T2F0-1", "A0AAA9S663-1", "A0AAA9U1A4-1", "F1MKY9-1", "A0AAA9S472-1", "F1MN35-1", "A0AAA9SMH0-1", "A0AAA9RSQ6-1", "F1N2S7-1", "F1N3W6-1", "A0AAA9S5X7-1", "F6QVY2-1", "A0A3Q1NKC2-1", "F1N5U0-1", "A0A3Q1MUZ6-1", "A0AAA9SJ92-1", "A0AAA9U136-1", "A0A3Q1LYH3-1", "A0A3Q1MXI5-1", "A0AAA9TJD5-1", "E1BBM3-1", "E1BEW4-1", "A0AAA9SK35-1", "F1MG29-1", "A0AAA9SGM8-1", "A0AAA9SXE3-1", "P05131-1", "E1BHE1-1", "A0A3Q1LGC2-1", "A0A3Q1NBC4-1", "F6QTX4-1", "A0AAA9SWA1-1", "A0AAA9TDL1-1", "F1MU35-1", "A5D791-1", "F1N664-1", "A0AAA9T3H7-1", "F1MAZ8-1", "F1MH23-1", "A0A3S5ZPR2-1", "F1MWN0-1", "P48734-1", "A0AAA9SNP6-1", "A0AAA9RVB1-1", "A0AAF6Z257-1", "A0A3Q1M614-1", "A0ABI0NQQ4-1", "E1BEI6-1", "F1N332-1", "A7MB74-1", "Q3SZJ2-1", "F1MXH6-1", "Q5E9L6-1", "A0AAF6YHL8-1", "Q08DZ2-1", "A0A3Q1LR28-1", "Q3MHJ9-1", "P00517-1", "Q3SYZ2-1", "A2VDU3-1", "P67827-1", "P05126-1", "F6RPH3-1", "A0AAA9T5C9-1", "Q3SWY6-1", "A7E3S4-1", "A1A4I4-1", "F1MI60-1", "E1BK52-1", "Q5E9X2-1", "Q17R13-1", "P68399-1", "F6Q6K1-1", "A0ABI0P0X3-1", "A0AAA9TNL3-1", "A0AAA9S4Z4-1", "F6PN06-1", "E1B8P9-1", "Q2HJF7-1", "A0AAA9S9A9-1", "E1BG90-1", "F1MGX2-1", "A0A3Q1M4X3-1", "E1BN63-1", "A0A3Q1LNU2-1", "F1MKK7-1", "A0AAA9SMT9-1", "A0A3Q1MKC7-1", "A0A3Q1LTC6-1", "A0AAA9TD48-1", "A0A3Q1MEZ6-1", "E1BPU0-1", "A0A3Q1N707-1", "A0A3Q1LNA9-1", "F1MBN7-1", "E1BJM5-1", "F1MFK1-1", "A0A3Q1LKG0-1", "Q1RMT7-1", "G5E5D4-1", "F1MYV9-1", "A0AAA9T584-1", "A0AAA9SLY1-1", "Q2TA06-1", "Q5E9Y0-1", "A0AAA9RWB8-1", "A0AAA9SX77-1", "A0A3Q1MRR6-1", "A0A3Q1N9F5-1", "A2VDV2-1", "A2VDZ4-1", "A5PKJ4-1", "E1BB50-1", "E1BB52-1", "F1MH24-1", "E1BCU9-1", "E1BFR5-1", "F1MDC9-1", "F1MNP4-1", "F1MQ96-1", "A0AAA9SU81-1", "P00516-1", "A0A3Q1LJU7-1", "A0A3Q1MS69-1", "A0A3Q1LU59-1", "A0A3Q1N4A7-1", "F1MY82-1", "F6RP02-1", "A7MBB4-1", "E1BMN8-1", "Q32KY4-1", "Q32PI1-1", "Q4TVR5-1", "Q5EAB2-1", "Q6TJY3-1", "E1B7H4-1", "E1BJ19-1", "E1BP01-1", "A0AAA9T940-1", "F1MC61-1", "E1BC64-1", "E1BNS8-1", "F1MPF0-1", "G5E518-1", "Q7YRC6-1", "Q95KV0-1", "Q9N0P9-1", "P20427-1", "P35507-1", "P35509-1", "P35508-1", "P46196-1", "P04409-1", "P05128-1", "H2XJE9-1", "Q0VD22-1", "Q2TBL8-1", "Q32L23-1", "Q3SX21-1", "Q3SZW1-1", "Q01314-1", "Q02399-1", "Q08E52-1", "Q0V7M1-1", "Q1RMT8-1", "Q2KIP2-1", "Q2LGB3-1", "Q2TA25-1", "Q3T0N5-1", "A0A3Q1LM61-1", "A0A3Q1LRM6-1", "E1BPB5-1", "A0A3Q1MHH5-1", "A0A3Q1M4N6-1", "G3MX00-1", "F1MH45-1", "A0A3Q1M334-1", "A0A3Q1M9L7-1", "A0A3Q1MA37-1", "A0A3Q1MHL3-1", "E1BP72-1", "A0AAA9T7Z7-1", "Q58D94-1", "F1MJ55-1", "E1BI47-1", "Q17QV9-1", "F1N6C1-1", "G3N2F6-1", "A0AAA9T3K7-1", "F1MPI8-1", "F1MVV5-1", "F6RD87-1", "G3N2D2-1", "G5E577-1", "E1B887-1", "E1B902-1", "E1BAL6-1", "E1BH31-1", "E1BJH5-1", "E1BK33-1", "F1MG77-1", "F1MKW8-1", "A0AAA9SJQ0-1", "E1BL08-1", "E1B793-1", "E1B7L9-1", "E1B9B6-1", "E1BFV2-1", "A0AAA9T042-1", "A0AAA9TU12-1", "A0AAA9T593-1", "A0A3Q1MI36-1", "A0AAA9RSJ2-1", "A0A3Q1NFM1-1", "A0AAA9T7I8-1", "A0A3Q1LWT7-1", "A0AAA9S954-1", "E1B9F9-1", "A0AAA9RWC6-1", "F6RLA2-1", "E1BCH5-1", "H2XJE8-1", "A0A3Q1LL42-1", "A0AAA9SVM5-1", "F1MYG2-1", "A0A3Q1LLH8-1", "A0A3Q1LN49-1", "A0A3Q1M5T5-1", "A0A3Q1LW88-1", "A0ABI0P2C0-1", "A0AAA9SG01-1", "E1BC36-1", "E1BB49-1", "E1BDG4-1", "E1BKX9-1", "E1BM19-1", "E1BQ34-1", "A0ABI0P443-1", "A0A3Q1LQP3-1", "A0A3Q1MNB4-1", "A0AAA9TWW0-1", "E1BGV8-1", "A0AAA9SIK7-1", "A0AAA9T8Z3-1", "F1N063-1", "A0A3Q1MD82-1", "F1N5K1-1", "E1BN72-1", "F1MLY7-1", "A0AAA9TVT5-1", "A0AAA9SKK8-1", "A0AAA9TNE6-1", "F1MWP1-1", "G3N022-1", "A0A3Q1MLK5-1", "A0AAA9TCI9-1", "F1MC27-1", "A0AAA9RW51-1", "A0AAA9TLV0-1", "E1B8J7-1", "F1MIB2-1", "E1B827-1", "A0A3Q1M1Z0-1", "G3N2J4-1", "F1MSV4-1", "E1B9Q2-1", "A0ABI0NJ75-1", "A0A3Q1M2U5-1", "A0A3Q1LLF0-1", "A0A3Q1M6N5-1", "A0AAF6DLR2-1", "A0ABI0NV47-1", "E1BPP1-1", "E1BC69-1", "E1BCC3-1", "F1MF36-1", "A0AAA9SH90-1", "E1BLQ5-1", "F1MG35-1", "F1MSI1-1", "F1MSX4-1", "F1MVR0-1", "F1MY55-1", "G5E5A0-1", "F1MUU2-1", "F1MY86-1", "A0AAA9SJA3-1", "F6Q5Z6-1", "A0AAA9TP92-1", "A0AAA9S2N3-1", "A0A3Q1MHM3-1", "F6QY93-1", "F6Q5B6-1", "A0AAA9SYW5-1", "A0A3Q1LH95-1", "A0AAF6DMH7-1", "A0AAF6YMX3-1", "F6Q9U9-1", "A0A3Q1MW77-1", "F1MF50-1", "P52175-1", "Q8MIT6-1", "Q28021-1", "A0ABI0NRQ5-1", "F1MDS3-1", "F1MM88-1", "A0ABI0NM98-1", "A0ABI0NS30-1", "A0ABI0P3N8-1" ], "evidence": [ { "id": "46608", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46608" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A3Q1LGC2", "gene_name": "HUNK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LGC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LGC2" } ] } ] }, { "uniprot_ac": "A0A3Q1LH95", "gene_name": "MAP3K20", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0A3Q1LH95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LH95" } ] } ] }, { "uniprot_ac": "A0A3Q1LJU7", "gene_name": "MAPK9", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0A3Q1LJU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LJU7" } ] } ] }, { "uniprot_ac": "A0A3Q1LKG0", "gene_name": "MINK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LKG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LKG0" } ] } ] }, { "uniprot_ac": "A0A3Q1LL42", "gene_name": "SBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LL42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LL42" } ] } ] }, { "uniprot_ac": "A0A3Q1LLF0", "gene_name": "PIK3R4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LLF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLF0" } ] } ] }, { "uniprot_ac": "A0A3Q1LLH8", "gene_name": "CDK15", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LLH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LLH8" } ] } ] }, { "uniprot_ac": "A0A3Q1LM61", "gene_name": "PKN3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1LM61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LM61" } ] } ] }, { "uniprot_ac": "A0A3Q1LN49", "gene_name": "CDK17", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0A3Q1LN49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LN49" } ] } ] }, { "uniprot_ac": "A0A3Q1LNA9", "gene_name": "PAK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1LNA9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNA9" } ] } ] }, { "uniprot_ac": "A0A3Q1LNU2", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0A3Q1LNU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1LNU2" } ] }, { 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O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M334" } ] } ] }, { "uniprot_ac": "A0A3Q1M4N6", "gene_name": "MYO3B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4N6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4N6" } ] } ] }, { "uniprot_ac": "A0A3Q1M4X3", "gene_name": "RPS6KA6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1M4X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M4X3" } ] } ] }, { "uniprot_ac": "A0A3Q1M5T5", "gene_name": "CAMK4", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1M5T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1M5T5" } ] } ] }, { "uniprot_ac": "A0A3Q1M614", "gene_name": "MAPKAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1M614", "database": "UniProtKB", "url": 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"ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1MKC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MKC7" } ] } ] }, { "uniprot_ac": "A0A3Q1MLK5", "gene_name": "LMTK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MLK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MLK5" } ] } ] }, { "uniprot_ac": "A0A3Q1MNB4", "gene_name": "STK32A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MNB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MNB4" } ] } ] }, { "uniprot_ac": "A0A3Q1MRR6", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0A3Q1MRR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MRR6" } ] } ] }, { "uniprot_ac": "A0A3Q1MRW3", "gene_name": "SNRK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": 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"https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MUZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MUZ6" } ] } ] }, { "uniprot_ac": "A0A3Q1MW77", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "A0A3Q1MW77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MW77" } ] } ] }, { "uniprot_ac": "A0A3Q1MXI5", "gene_name": "DAPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1MXI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1MXI5" } ] } ] }, { "uniprot_ac": "A0A3Q1N4A7", "gene_name": "CIT", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1N4A7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N4A7" } ] } ] }, { "uniprot_ac": "A0A3Q1N707", "gene_name": "WNK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1N707", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1N707" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": 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"https://www.uniprot.org/uniprotkb/A0A3Q1N9F5" } ] } ] }, { "uniprot_ac": "A0A3Q1NBC4", "gene_name": "SRPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NBC4" } ] } ] }, { "uniprot_ac": "A0A3Q1NFM1", "gene_name": "LOC100138998", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3Q1NFM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NFM1" } ] } ] }, { "uniprot_ac": "A0A3Q1NKC2", "gene_name": "CAMK2G", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0A3Q1NKC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3Q1NKC2" } ] } ] }, { "uniprot_ac": "A0A3S5ZPR2", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A3S5ZPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A3S5ZPR2" } ] } ] }, { "uniprot_ac": "A0AAA9RSJ2", "gene_name": "MKNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSJ2" } ] } ] }, { "uniprot_ac": "A0AAA9RSQ6", "gene_name": "TRPM6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RSQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RSQ6" } ] } ] }, { "uniprot_ac": "A0AAA9RTJ4", "gene_name": "PIKFYVE", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.1.150", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RTJ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RTJ4", "database": "UniProtKB", "url": 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"ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RW51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RW51" } ] } ] }, { "uniprot_ac": "A0AAA9RWB8", "gene_name": "TRIO", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9RWB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWB8" } ] } ] }, { "uniprot_ac": "A0AAA9RWC6", "gene_name": "CHEK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9RWC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9RWC6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": 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"uniprot_ac": "A0AAA9S663", "gene_name": "PDPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S663", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S663" } ] } ] }, { "uniprot_ac": "A0AAA9S954", "gene_name": "CAMKK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9S954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S954" } ] } ] }, { "uniprot_ac": "A0AAA9S9A9", "gene_name": "NEK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9S9A9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9S9A9" } ] } ] }, { "uniprot_ac": "A0AAA9SG01", "gene_name": "ERN1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SG01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SG01" } ] } ] }, { "uniprot_ac": "A0AAA9SGM8", "gene_name": "MKNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SGM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SGM8" } ] } ] }, { "uniprot_ac": "A0AAA9SH90", "gene_name": "DAPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SH90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SH90" } ] } ] }, { "uniprot_ac": "A0AAA9SIK7", "gene_name": "NEK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SIK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SIK7" } ] } ] }, { "uniprot_ac": "A0AAA9SJ92", "gene_name": "RPS6KA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJ92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJ92" } ] } ] }, { "uniprot_ac": "A0AAA9SJA3", "gene_name": "TTBK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJA3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJA3" } ] } ] }, { "uniprot_ac": "A0AAA9SJQ0", "gene_name": "RPS6KA4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SJQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SJQ0" } ] } ] }, { "uniprot_ac": "A0AAA9SK35", "gene_name": "PRKG2", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "A0AAA9SK35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SK35" } ] } ] }, { "uniprot_ac": "A0AAA9SKK8", "gene_name": "MAP3K4", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SKK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SKK8" } ] } ] }, { "uniprot_ac": "A0AAA9SLY1", "gene_name": "NEK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SLY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SLY1" } ] } ] }, { "uniprot_ac": "A0AAA9SMH0", "gene_name": "DCLK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SMH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMH0" } ] } ] }, { "uniprot_ac": "A0AAA9SMT9", "gene_name": "MAP3K12", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SMT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SMT9" } ] } ] }, { "uniprot_ac": "A0AAA9SNP6", "gene_name": "MOS", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SNP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SNP6" } ] } ] }, { "uniprot_ac": "A0AAA9SU81", "gene_name": "PRKAA2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0AAA9SU81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SU81" } ] } ] }, { "uniprot_ac": "A0AAA9SVM5", "gene_name": "MAP3K3", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SVM5" } ] } ] }, { "uniprot_ac": "A0AAA9SWA1", "gene_name": "STK26", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SWA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SWA1" } ] } ] }, { "uniprot_ac": "A0AAA9SX77", "gene_name": "CDK14", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9SX77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SX77" } ] } ] }, { "uniprot_ac": "A0AAA9SXE3", "gene_name": "MAP3K6", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A0AAA9SXE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SXE3" } ] } ] }, { "uniprot_ac": "A0AAA9SYW5", "gene_name": "NEK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9SYW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9SYW5" } ] } ] }, { "uniprot_ac": "A0AAA9T042", "gene_name": "DYRK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9T042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T042" } ] } ] }, { "uniprot_ac": "A0AAA9T2F0", "gene_name": "BRAF", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T2F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T2F0" } ] } ] }, { "uniprot_ac": "A0AAA9T3H7", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AAA9T3H7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3H7" } ] } ] }, { "uniprot_ac": "A0AAA9T3K7", "gene_name": "WNK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T3K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T3K7" } ] } ] }, { "uniprot_ac": "A0AAA9T584", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T584" } ] } ] }, { "uniprot_ac": "A0AAA9T593", "gene_name": "SRPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T593" } ] } ] }, { "uniprot_ac": "A0AAA9T5C9", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAA9T5C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T5C9" } ] } ] }, { "uniprot_ac": "A0AAA9T7I8", "gene_name": "TSSK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7I8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7I8" } ] } ] }, { "uniprot_ac": "A0AAA9T7L6", "gene_name": "RPS6KC1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7L6" } ] } ] }, { "uniprot_ac": "A0AAA9T7Z7", "gene_name": "RPS6KA5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T7Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T7Z7" } ] } ] }, { "uniprot_ac": "A0AAA9T8T9", "gene_name": "MARK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8T9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8T9" } ] } ] }, { "uniprot_ac": "A0AAA9T8Z3", "gene_name": "STK32C", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9T8Z3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T8Z3" } ] } ] }, { "uniprot_ac": "A0AAA9T940", "gene_name": "PLK2", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A0AAA9T940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9T940" } ] } ] }, { "uniprot_ac": "A0AAA9TCI9", "gene_name": "MOK", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAA9TCI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TCI9" } ] } ] }, { "uniprot_ac": "A0AAA9TD48", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AAA9TD48", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TD48" } ] } ] }, { "uniprot_ac": "A0AAA9TDL1", "gene_name": "SBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TDL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TDL1" } ] } ] }, { "uniprot_ac": "A0AAA9TJD5", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TJD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TJD5" } ] } ] }, { "uniprot_ac": "A0AAA9TLV0", "gene_name": "STK32B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TLV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TLV0" } ] } ] }, { "uniprot_ac": "A0AAA9TMV7", "gene_name": "SMG1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TMV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TMV7" } ] } ] }, { "uniprot_ac": "A0AAA9TNE6", "gene_name": "TLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNE6" } ] } ] }, { "uniprot_ac": "A0AAA9TNL3", "gene_name": "SLK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TNL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TNL3" } ] } ] }, { "uniprot_ac": "A0AAA9TP92", "gene_name": "CAMK1", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "A0AAA9TP92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TP92" } ] } ] }, { "uniprot_ac": "A0AAA9TU12", "gene_name": "PRKCQ", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9TU12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TU12" } ] } ] }, { "uniprot_ac": "A0AAA9TVT5", "gene_name": "CASK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TVT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TVT5" } ] } ] }, { "uniprot_ac": "A0AAA9TWW0", "gene_name": "TBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9TWW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9TWW0" } ] } ] }, { "uniprot_ac": "A0AAA9U136", "gene_name": "PRKD2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0AAA9U136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U136" } ] } ] }, { "uniprot_ac": "A0AAA9U1A4", "gene_name": "NUAK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1A4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1A4" } ] } ] }, { "uniprot_ac": "A0AAA9U1M9", "gene_name": "DMPK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1M9" } ] } ] }, { "uniprot_ac": "A0AAA9U1R3", "gene_name": "DCLK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAA9U1R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAA9U1R3" } ] } ] }, { "uniprot_ac": "A0AAF6DLR2", "gene_name": "CDK18", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6DLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DLR2" } ] } ] }, { "uniprot_ac": "A0AAF6DMH7", "gene_name": "RIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6DMH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6DMH7" } ] } ] }, { "uniprot_ac": "A0AAF6YHL8", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A0AAF6YHL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YHL8" } ] } ] }, { "uniprot_ac": "A0AAF6YMX3", "gene_name": "CDK9", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "A0AAF6YMX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6YMX3" } ] } ] }, { "uniprot_ac": "A0AAF6Z257", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0AAF6Z257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AAF6Z257" } ] } ] }, { "uniprot_ac": "A0ABI0NJ75", "gene_name": "PAK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NJ75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NJ75" } ] } ] }, { "uniprot_ac": "A0ABI0NM98", "gene_name": "KALRN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NM98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NM98" } ] } ] }, { "uniprot_ac": "A0ABI0NMT8", "gene_name": "PIK3CG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] }, { "ec_number": "2.7.1.154", "activity": "", "evidence": [ { "id": "A0ABI0NMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NMT8" } ] } ] }, { "uniprot_ac": "A0ABI0NQQ4", "gene_name": "PRKAA1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] }, { "ec_number": "2.7.11.31", "activity": "", "evidence": [ { "id": "A0ABI0NQQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NQQ4" } ] } ] }, { "uniprot_ac": "A0ABI0NRQ5", "gene_name": "LOC101905399", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0ABI0NRQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NRQ5" } ] } ] }, { "uniprot_ac": "A0ABI0NS30", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A0ABI0NS30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NS30" } ] } ] }, { "uniprot_ac": "A0ABI0NV47", "gene_name": "DCLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0NV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0NV47" } ] } ] }, { "uniprot_ac": "A0ABI0P0X3", "gene_name": "", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P0X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P0X3" } ] } ] }, { "uniprot_ac": "A0ABI0P2C0", "gene_name": "TSSK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P2C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P2C0" } ] } ] }, { "uniprot_ac": "A0ABI0P3N8", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "A0ABI0P3N8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3N8" } ] } ] }, { "uniprot_ac": "A0ABI0P3P6", "gene_name": "MAST4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P3P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P3P6" } ] } ] }, { "uniprot_ac": "A0ABI0P443", "gene_name": "SGK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0ABI0P443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0ABI0P443" } ] } ] }, { "uniprot_ac": "A1A4I4", "gene_name": "PKN1", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "A1A4I4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A4I4" } ] } ] }, { "uniprot_ac": "A2VDU3", "gene_name": "MAP3K7", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A2VDU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDU3" } ] } ] }, { "uniprot_ac": "A2VDV2", "gene_name": "STK38", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A2VDV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDV2" } ] } ] }, { "uniprot_ac": "A2VDZ4", "gene_name": "PLK4", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "A2VDZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VDZ4" } ] } ] }, { "uniprot_ac": "A5D791", "gene_name": "EIF2AK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A5D791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5D791" } ] } ] }, { "uniprot_ac": "A5PKJ4", "gene_name": "MAPK7", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "A5PKJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PKJ4" } ] } ] }, { "uniprot_ac": "A7E3S4", "gene_name": "RAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3S4" } ] } ] }, { "uniprot_ac": "A7E3X2", "gene_name": "CSNK1G1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7E3X2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7E3X2" } ] } ] }, { "uniprot_ac": "A7MB74", "gene_name": "SGK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A7MB74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MB74" } ] } ] }, { "uniprot_ac": "A7MBB4", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "A7MBB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A7MBB4" } ] } ] }, { "uniprot_ac": "E1B754", "gene_name": "MAST2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B754" } ] } ] }, { "uniprot_ac": "E1B793", "gene_name": "STK36", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B793" } ] } ] }, { "uniprot_ac": "E1B7H4", "gene_name": "MAP3K10", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1B7H4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7H4" } ] } ] }, { "uniprot_ac": "E1B7L9", "gene_name": "PRKD3", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "E1B7L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B7L9" } ] } ] }, { "uniprot_ac": "E1B827", "gene_name": "NEK8", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B827" } ] } ] }, { "uniprot_ac": "E1B887", "gene_name": "RIOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B887" } ] } ] }, { "uniprot_ac": "E1B8J7", "gene_name": "ERN2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B8J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8J7" } ] } ] }, { "uniprot_ac": "E1B8P9", "gene_name": "MAPK3", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1B8P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B8P9" } ] } ] }, { "uniprot_ac": "E1B902", "gene_name": "MAP4K2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B902" } ] } ] }, { "uniprot_ac": "E1B9B6", "gene_name": "NUAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9B6" } ] } ] }, { "uniprot_ac": "E1B9F9", "gene_name": "LATS2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1B9F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9F9" } ] } ] }, { "uniprot_ac": "E1B9Q2", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1B9Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1B9Q2" } ] } ] }, { "uniprot_ac": "E1BAL6", "gene_name": "EIF2AK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BAL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BAL6" } ] } ] }, { "uniprot_ac": "E1BB49", "gene_name": "HIPK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BB49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB49" } ] } ] }, { "uniprot_ac": "E1BB50", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB50" } ] } ] }, { "uniprot_ac": "E1BB52", "gene_name": "CDK13", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BB52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BB52" } ] } ] }, { "uniprot_ac": "E1BBM3", "gene_name": "NEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BBM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BBM3" } ] } ] }, { "uniprot_ac": "E1BC36", "gene_name": "CDK6", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BC36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC36" } ] } ] }, { "uniprot_ac": "E1BC64", "gene_name": "LIMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC64" } ] } ] }, { "uniprot_ac": "E1BC69", "gene_name": "HIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BC69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BC69" } ] } ] }, { "uniprot_ac": "E1BCC3", "gene_name": "UHMK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCC3" } ] } ] }, { "uniprot_ac": "E1BCH5", "gene_name": "LATS1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCH5" } ] } ] }, { "uniprot_ac": "E1BCU9", "gene_name": "STK11", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BCU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BCU9" } ] } ] }, { "uniprot_ac": "E1BDG4", "gene_name": "MAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BDG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BDG4" } ] } ] }, { "uniprot_ac": "E1BEI6", "gene_name": "ATM", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEI6" } ] } ] }, { "uniprot_ac": "E1BEW4", "gene_name": "LOC613515", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BEW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BEW4" } ] } ] }, { "uniprot_ac": "E1BFR5", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BFR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFR5" } ] } ] }, { "uniprot_ac": "E1BFV2", "gene_name": "MAP3K21", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BFV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BFV2" } ] } ] }, { "uniprot_ac": "E1BG90", "gene_name": "DYRK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BG90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BG90" } ] } ] }, { "uniprot_ac": "E1BGV8", "gene_name": "MAP3K19", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BGV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BGV8" } ] } ] }, { "uniprot_ac": "E1BH31", "gene_name": "MAP4K1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BH31", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BH31" } ] } ] }, { "uniprot_ac": "E1BHE1", "gene_name": "TAOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BHE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BHE1" } ] } ] }, { "uniprot_ac": "E1BI01", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "E1BI01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI01" } ] } ] }, { "uniprot_ac": "E1BI47", "gene_name": "PLK5", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "E1BI47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BI47" } ] } ] }, { "uniprot_ac": "E1BJ19", "gene_name": "TAOK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJ19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJ19" } ] } ] }, { "uniprot_ac": "E1BJH5", "gene_name": "MAP4K3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJH5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJH5" } ] } ] }, { "uniprot_ac": "E1BJM5", "gene_name": "MTERF4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BJM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BJM5" } ] } ] }, { "uniprot_ac": "E1BK33", "gene_name": "MAST1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK33" } ] } ] }, { "uniprot_ac": "E1BK52", "gene_name": "STK10", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BK52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BK52" } ] } ] }, { "uniprot_ac": "E1BKX9", "gene_name": "CDKL5", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BKX9" } ] } ] }, { "uniprot_ac": "E1BL08", "gene_name": "MAP3K14", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "E1BL08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BL08" } ] } ] }, { "uniprot_ac": "E1BLQ5", "gene_name": "RPS6KB2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BLQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BLQ5" } ] } ] }, { "uniprot_ac": "E1BM19", "gene_name": "CDKL3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "E1BM19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BM19" } ] } ] }, { "uniprot_ac": "E1BMN8", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "E1BMN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BMN8" } ] } ] }, { "uniprot_ac": "E1BN63", "gene_name": "WNK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN63" } ] } ] }, { "uniprot_ac": "E1BN72", "gene_name": "NIM1K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BN72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BN72" } ] } ] }, { "uniprot_ac": "E1BNH0", "gene_name": "WNK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNH0" } ] } ] }, { "uniprot_ac": "E1BNS8", "gene_name": "SIK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BNS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BNS8" } ] } ] }, { "uniprot_ac": "E1BP01", "gene_name": "MYO3A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP01" } ] } ] }, { "uniprot_ac": "E1BP72", "gene_name": "CDC42BPB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BP72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BP72" } ] } ] }, { "uniprot_ac": "E1BPB5", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPB5" } ] } ] }, { "uniprot_ac": "E1BPP1", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E1BPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPP1" } ] } ] }, { "uniprot_ac": "E1BPU0", "gene_name": "LRRK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BPU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BPU0" } ] } ] }, { "uniprot_ac": "E1BQ34", "gene_name": "HIPK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "E1BQ34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E1BQ34" } ] } ] }, { "uniprot_ac": "F1MAZ8", "gene_name": "MARK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MAZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAZ8" } ] } ] }, { "uniprot_ac": "F1MBN7", "gene_name": "RIOK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MBN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MBN7" } ] } ] }, { "uniprot_ac": "F1MC27", "gene_name": "LMTK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MC27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC27" } ] } ] }, { "uniprot_ac": "F1MC61", "gene_name": "MAP3K11", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MC61" } ] } ] }, { "uniprot_ac": "F1MDC9", "gene_name": "PRKCE", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MDC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDC9" } ] } ] }, { "uniprot_ac": "F1MDS3", "gene_name": "PCK2", "activity": [ { "ec_number": "4.1.1.32", "activity": "ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2.", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] }, { "ec_number": "4.1.1.32", "activity": "", "evidence": [ { "id": "F1MDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MDS3" } ] } ] }, { "uniprot_ac": "F1MF36", "gene_name": "KSR2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MF36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF36" } ] } ] }, { "uniprot_ac": "F1MF50", "gene_name": "ROCK1", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "F1MF50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MF50" } ] } ] }, { "uniprot_ac": "F1MFK1", "gene_name": "PKN2", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MFK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MFK1" } ] } ] }, { "uniprot_ac": "F1MG29", "gene_name": "TSSK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG29" } ] } ] }, { "uniprot_ac": "F1MG35", "gene_name": "CIITA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG35" } ] } ] }, { "uniprot_ac": "F1MG77", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MG77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MG77" } ] } ] }, { "uniprot_ac": "F1MGX2", "gene_name": "MAP3K13", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MGX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MGX2" } ] } ] }, { "uniprot_ac": "F1MH23", "gene_name": "MAPKAPK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH23" } ] } ] }, { "uniprot_ac": "F1MH24", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH24" } ] } ] }, { "uniprot_ac": "F1MH45", "gene_name": "CDC42BPA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MH45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MH45" } ] } ] }, { "uniprot_ac": "F1MI60", "gene_name": "MAP4K4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MI60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MI60" } ] } ] }, { "uniprot_ac": "F1MIB2", "gene_name": "GAK", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MIB2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MIB2" } ] } ] }, { "uniprot_ac": "F1MJ55", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MJ55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MJ55" } ] } ] }, { "uniprot_ac": "F1MKK7", "gene_name": "PKMYT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKK7" } ] } ] }, { "uniprot_ac": "F1MKW8", "gene_name": "SIK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKW8" } ] } ] }, { "uniprot_ac": "F1MKY9", "gene_name": "ALPK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MKY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKY9" } ] } ] }, { "uniprot_ac": "F1MLY7", "gene_name": "ATR", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MLY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLY7" } ] } ] }, { "uniprot_ac": "F1MM88", "gene_name": "NEK9", "activity": [ { "ec_number": "2.7.11.38", "activity": "L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] }, { "ec_number": "2.7.11.38", "activity": "", "evidence": [ { "id": "F1MM88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MM88" } ] } ] }, { "uniprot_ac": "F1MN35", "gene_name": "PDIK1L", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MN35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MN35" } ] } ] }, { "uniprot_ac": "F1MNP4", "gene_name": "RPS6KB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MNP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MNP4" } ] } ] }, { "uniprot_ac": "F1MPF0", "gene_name": "TRPM7", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MPF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPF0" } ] } ] }, { "uniprot_ac": "F1MPI8", "gene_name": "CDK8", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1MPI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MPI8" } ] } ] }, { "uniprot_ac": "F1MQ96", "gene_name": "PRKCI", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MQ96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MQ96" } ] } ] }, { "uniprot_ac": "F1MSI1", "gene_name": "STK17B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSI1" } ] } ] }, { "uniprot_ac": "F1MSV4", "gene_name": "SGK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MSV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSV4" } ] } ] }, { "uniprot_ac": "F1MSX4", "gene_name": "MAP3K2", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MSX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MSX4" } ] } ] }, { "uniprot_ac": "F1MU35", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MU35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MU35" } ] } ] }, { "uniprot_ac": "F1MUU2", "gene_name": "STK35", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MUU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MUU2" } ] } ] }, { "uniprot_ac": "F1MVR0", "gene_name": "CDK19", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1MVR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVR0" } ] } ] }, { "uniprot_ac": "F1MVV5", "gene_name": "MAPK4", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F1MVV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MVV5" } ] } ] }, { "uniprot_ac": "F1MWN0", "gene_name": "EIF2AK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWN0" } ] } ] }, { "uniprot_ac": "F1MWP1", "gene_name": "BUB1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MWP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MWP1" } ] } ] }, { "uniprot_ac": "F1MXH6", "gene_name": "MAP3K5", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1MXH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MXH6" } ] } ] }, { "uniprot_ac": "F1MY55", "gene_name": "PAK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY55" } ] } ] }, { "uniprot_ac": "F1MY82", "gene_name": "PRKCH", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "F1MY82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY82" } ] } ] }, { "uniprot_ac": "F1MY86", "gene_name": "AURKC", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MY86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MY86" } ] } ] }, { "uniprot_ac": "F1MYG2", "gene_name": "TLK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYG2" } ] } ] }, { "uniprot_ac": "F1MYM3", "gene_name": "PIK3CB", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "F1MYM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYM3" } ] } ] }, { "uniprot_ac": "F1MYV9", "gene_name": "OXSR1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1MYV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MYV9" } ] } ] }, { "uniprot_ac": "F1N063", "gene_name": "CAMK1D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F1N063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N063" } ] } ] }, { "uniprot_ac": "F1N2S7", "gene_name": "TSSK6", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N2S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N2S7" } ] } ] }, { "uniprot_ac": "F1N332", "gene_name": "ULK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N332" } ] } ] }, { "uniprot_ac": "F1N3W6", "gene_name": "MAP3K15", "activity": [ { "ec_number": "2.7.11.25", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "F1N3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N3W6" } ] } ] }, { "uniprot_ac": "F1N5K1", "gene_name": "CDK11B", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F1N5K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5K1" } ] } ] }, { "uniprot_ac": "F1N5U0", "gene_name": "ALPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N5U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N5U0" } ] } ] }, { "uniprot_ac": "F1N664", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "F1N664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N664" } ] } ] }, { "uniprot_ac": "F1N6C1", "gene_name": "LRRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F1N6C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1N6C1" } ] } ] }, { "uniprot_ac": "F6PN06", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6PN06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6PN06" } ] } ] }, { "uniprot_ac": "F6Q5B6", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F6Q5B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5B6" } ] } ] }, { "uniprot_ac": "F6Q5Z6", "gene_name": "BUB1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q5Z6" } ] } ] }, { "uniprot_ac": "F6Q6K1", "gene_name": "CHEK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6Q6K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q6K1" } ] } ] }, { "uniprot_ac": "F6Q9U9", "gene_name": "PNCK", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "F6Q9U9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6Q9U9" } ] } ] }, { "uniprot_ac": "F6QTX4", "gene_name": "RIPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6QTX4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QTX4" } ] } ] }, { "uniprot_ac": "F6QVY2", "gene_name": "CDK20", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QVY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QVY2" } ] } ] }, { "uniprot_ac": "F6QY93", "gene_name": "CDK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "F6QY93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6QY93" } ] } ] }, { "uniprot_ac": "F6RD87", "gene_name": "SRPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RD87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RD87" } ] } ] }, { "uniprot_ac": "F6RG88", "gene_name": "NEK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RG88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RG88" } ] } ] }, { "uniprot_ac": "F6RLA2", "gene_name": "TSSK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RLA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RLA2" } ] } ] }, { "uniprot_ac": "F6RP02", "gene_name": "PIM2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "F6RP02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RP02" } ] } ] }, { "uniprot_ac": "F6RPH3", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "F6RPH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6RPH3" } ] } ] }, { "uniprot_ac": "G3MX00", "gene_name": "", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G3MX00", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3MX00" } ] } ] }, { "uniprot_ac": "G3N022", "gene_name": "SPEG", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N022", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N022" } ] } ] }, { "uniprot_ac": "G3N2D2", "gene_name": "TSSK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2D2" } ] } ] }, { "uniprot_ac": "G3N2F6", "gene_name": "PIM3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2F6" } ] } ] }, { "uniprot_ac": "G3N2J4", "gene_name": "TTBK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3N2J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3N2J4" } ] } ] }, { "uniprot_ac": "G5E518", "gene_name": "CDK12", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "G5E518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E518" } ] } ] }, { "uniprot_ac": "G5E577", "gene_name": "MAPK6", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "G5E577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E577" } ] } ] }, { "uniprot_ac": "G5E5A0", "gene_name": "STK17A", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5A0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5A0" } ] } ] }, { "uniprot_ac": "G5E5D4", "gene_name": "MARK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] }, { "ec_number": "2.7.11.26", "activity": "", "evidence": [ { "id": "G5E5D4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5D4" } ] } ] }, { "uniprot_ac": "G5E5K2", "gene_name": "MASTL", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G5E5K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G5E5K2" } ] } ] }, { "uniprot_ac": "H2XJE8", "gene_name": "AAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "H2XJE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE8" } ] } ] }, { "uniprot_ac": "H2XJE9", "gene_name": "NLK", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "H2XJE9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/H2XJE9" } ] } ] }, { "uniprot_ac": "P00516", "gene_name": "PRKG1", "activity": [ { "ec_number": "2.7.11.12", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] }, { "ec_number": "2.7.11.12", "activity": "", "evidence": [ { "id": "P00516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00516" } ] } ] }, { "uniprot_ac": "P00517", "gene_name": "PRKACA", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P00517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P00517" } ] } ] }, { "uniprot_ac": "P04409", "gene_name": "PRKCA", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P04409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P04409" } ] } ] }, { "uniprot_ac": "P05126", "gene_name": "PRKCB", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05126" } ] } ] }, { "uniprot_ac": "P05128", "gene_name": "PRKCG", "activity": [ { "ec_number": "2.7.11.13", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P05128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05128" } ] } ] }, { "uniprot_ac": "P05131", "gene_name": "PRKACB", "activity": [ { "ec_number": "2.7.11.11", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] }, { "ec_number": "2.7.11.11", "activity": "", "evidence": [ { "id": "P05131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05131" } ] } ] }, { "uniprot_ac": "P20427", "gene_name": "CSNK2A2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P20427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P20427" } ] } ] }, { "uniprot_ac": "P32871", "gene_name": "PIK3CA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.153", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.1.137", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P32871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P32871" } ] } ] }, { "uniprot_ac": "P35507", "gene_name": "CSNK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35507" } ] } ] }, { "uniprot_ac": "P35508", "gene_name": "CSNK1D", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.26", "activity": "L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+).", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35508" } ] } ] }, { "uniprot_ac": "P35509", "gene_name": "CSNK1G3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P35509", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P35509" } ] } ] }, { "uniprot_ac": "P46196", "gene_name": "MAPK1", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P46196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46196" } ] } ] }, { "uniprot_ac": "P48734", "gene_name": "CDK1", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+).", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "P48734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48734" } ] } ] }, { "uniprot_ac": "P52175", "gene_name": "NME1", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "UDP + ATP = UTP + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.13.3", "activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.18", "activity": "(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP.", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "3.1.24.-", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P52175", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P52175" } ] } ] }, { "uniprot_ac": "P67827", "gene_name": "CSNK1A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P67827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P67827" } ] } ] }, { "uniprot_ac": "P68399", "gene_name": "CSNK2A1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P68399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P68399" } ] } ] }, { "uniprot_ac": "Q01314", "gene_name": "AKT1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q01314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q01314" } ] } ] }, { "uniprot_ac": "Q02399", "gene_name": "CDK5", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q02399", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q02399" } ] } ] }, { "uniprot_ac": "Q08DZ2", "gene_name": "PRP4K", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q08DZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08DZ2" } ] } ] }, { "uniprot_ac": "Q08E52", "gene_name": "PAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08E52", "database": "UniProtKB", "url": 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{ "id": "Q0VD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q0VD22" } ] } ] }, { "uniprot_ac": "Q17QV9", "gene_name": "STK40", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17QV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17QV9" } ] } ] }, { "uniprot_ac": "Q17R13", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q17R13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q17R13" } ] } ] }, { "uniprot_ac": "Q1RMT7", "gene_name": "RIOK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT7" } ] } ] }, { "uniprot_ac": "Q1RMT8", "gene_name": "IRAK4", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q1RMT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RMT8" } ] } ] }, { "uniprot_ac": "Q28021", "gene_name": "ROCK2", "activity": [ { "ec_number": "2.7.11.39", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] }, { "ec_number": "2.7.11.39", "activity": "", "evidence": [ { "id": "Q28021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q28021" } ] } ] }, { "uniprot_ac": "Q2HJF7", "gene_name": "CAMK2D", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q2HJF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2HJF7" } ] } ] }, { "uniprot_ac": "Q2KIP2", "gene_name": "HASPIN", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KIP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KIP2" } ] } ] }, { "uniprot_ac": "Q2KJG8", "gene_name": "BCKDK", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2KJG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2KJG8" } ] } ] }, { "uniprot_ac": "Q2LGB3", "gene_name": "IRAK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2LGB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2LGB3" } ] } ] }, { "uniprot_ac": "Q2TA06", "gene_name": "AURKA", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q2TA06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA06" } ] } ] }, { "uniprot_ac": "Q2TA25", "gene_name": "PLK1", "activity": [ { "ec_number": "2.7.11.21", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] }, { "ec_number": "2.7.11.21", "activity": "", "evidence": [ { "id": "Q2TA25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TA25" } ] } ] }, { "uniprot_ac": "Q2TBL8", "gene_name": "CDK10", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2TBL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2TBL8" } ] } ] }, { "uniprot_ac": "Q2YDN8", "gene_name": "VRK3", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q2YDN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2YDN8" } ] } ] }, { "uniprot_ac": "Q32KY4", "gene_name": "CDK4", "activity": [ { "ec_number": "2.7.11.22", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q32KY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32KY4" } ] } ] }, { "uniprot_ac": "Q32L23", "gene_name": "LIMK2", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32L23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32L23" } ] } ] }, { "uniprot_ac": "Q32PI1", "gene_name": "VRK1", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q32PI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q32PI1" } ] } ] }, { "uniprot_ac": "Q3MHJ9", "gene_name": "CAMK2B", "activity": [ { "ec_number": "2.7.11.17", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] }, { "ec_number": "2.7.11.17", "activity": "", "evidence": [ { "id": "Q3MHJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHJ9" } ] } ] }, { "uniprot_ac": "Q3SWY6", "gene_name": "STK25", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SWY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SWY6" } ] } ] }, { "uniprot_ac": "Q3SX21", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q3SX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SX21" } ] } ] }, { "uniprot_ac": "Q3SYZ2", "gene_name": "MAPKAPK3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SYZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SYZ2" } ] } ] }, { "uniprot_ac": "Q3SZJ2", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZJ2" } ] } ] }, { "uniprot_ac": "Q3SZW1", "gene_name": "TSSK1B", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q3SZW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3SZW1" } ] } ] }, { "uniprot_ac": "Q3T0N5", "gene_name": "MAPK13", "activity": [ { "ec_number": "2.7.11.24", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "Q3T0N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0N5" } ] } ] }, { "uniprot_ac": "Q3T0P6", "gene_name": "PGK1", "activity": [ { "ec_number": "2.7.2.3", "activity": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP.", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": "2.7.2.3", "activity": "", "evidence": [ { "id": "Q3T0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3T0P6" } ] }, { "ec_number": 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"mass": { "chemical_mass": 515037.0, "monoisotopic_mass": 515037.0 }, "refseq": {}, "gene_names": [], "protein_names": [ { "name": "Low-density lipoprotein receptor-related protein 1B", "type": "recommended", "evidence": [ { "id": "F1MKZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKZ6/entry#names_and_taxonomy" } ] }, { "name": "Low-density lipoprotein receptor-related protein-deleted in tumor", "type": "synonym", "evidence": [ { "id": "F1MKZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKZ6/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.", "evidence": [ { "database": "UniProtKB", "id": "F1MKZ6", "url": "https://www.uniprot.org/uniprotkb/F1MKZ6#function" }, { "database": "UniProtKB", "id": "ARBA00059602", "url": "https://www.uniprot.org/uniprotkb/ARBA00059602#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MKZ6", "url": "https://www.uniprot.org/uniprotkb/F1MKZ6" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "", "url": "https://www.uniprot.org/uniprotkb/F1MKZ6", "locus": {} } ], "crossref": [ { "id": "ENSBTAG00000024632", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000024632", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00112", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00112", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR000033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011042", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011042", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026823", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026823", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR049883", "url": "https://www.ebi.ac.uk/interpro/entry/IPR049883", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051221", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051221", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MKZ6", "url": "https://www.orthodb.org/?gene=F1MKZ6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22722", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22722", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22722:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22722:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00008", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00057", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00057", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF00058", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00058", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF07645", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07645", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF12662", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12662", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF14670", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14670", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MKZ6", "url": "https://www.uniprot.org/uniprotkb/F1MKZ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MKZ6-1", "url": "https://www.uniprot.org/uniprotkb/F1MKZ6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSEFLLALLTLSGLLPVAKVLTMGADRDQQSCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVETKCPWNHIACLGANKCIHLSQLCNGVLDCLDGYDEGVHCRELLPNCQQLNCQHKCAMVRNSTMCYCEDGFEIKEDGRSCKDQDECAIYGTCSQSCVNTYGSYACSCVEGYIMQPDNRSCKAKNEPTDKPPLLLIANSETIEIFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNRLKCIQITKTGRLTDEWTISILQSFHNVQQMAIDWLTRNLYFVDHVSDRIFVCDYNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKWVYWVDLYLDYVEVVDYQGKNRHTIIQGRQVKHLYGITVFEDYLYATDADNFNIIRINRFNGSDIHSLIKMENAKAIRIYQKRIQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETSYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVSGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTHTLYWCDAYYDHIEKVFLNGTHRKIVYSGKELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITNEVTLLRRERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTNCIFNPGEVLPQICKAGEFRCRNRHCIQARWKCDGDDDCLDGSDEDSLSCYNHSCPDDQFKCKNNRCIPKRWLCDGANDCGSNEDESNQTCSARTCEVDQFSCGNGRCIPRAWLCDREDDCGDHTDEIASCEFPTCEPLTQFICKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFSCSSGRCIPGHWACDGDNDCGDFSDEINCTREEIHSPAGCNANEFQCHPDGNCIPDVWHCDGEKDCEDGSDEKGCNGTLRLCDHKTKFSCRSTGRCISKAWVCDGDIDCEDQSDEDDCDNFLCGPPKYPCANDTSVCLQPEKLCNGRWDCPDGSDEGDLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLGRDNKTCEIVDYCSNHLKCSQVCEQHKQTVKCSCYEGWKLDVDGQSCSSVDPFEAFIIFSIRHEIRKIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRFGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTSMIEIIRGHEYLSHPFAVSLYGSDVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGRGPCSHMCLINHNRSAACACPHLMKLSSNKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLTVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGSNLEVIETMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTVLRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCRGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAIDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIALHPEKGYLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDFEENKLYWCDARTDKIERIDLETGGNREMVLSGNNVDMFSVAVFGAYIYWSDRAHANGSIRRGHKNDATETVTMRTGLGVNLKEVKIFNRVREKGTNVCAKNNGGCQQLCLYRGNSWRTCACAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRKGSNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVIAMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDHRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNIYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCVPHSKLCDGENDCGDNSDELDCKVSTCAAVEFRCTDGMCIPRSARCNQNIDCADASDEKNCNNTDCTYFYKLGVKTTGFIRCNSTSLCVLPAWICDGSNDCGDYSDELKCPVQNKHKCEENYFGCPSGRCILNTWVCDGQKDCEDGLDEFHCDASCSWNQFACSTEKCISKHWICDGEDDCEDGLDESDSICGTITCAADMFSCQGSRACVPRHWLCDGERDCPNGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESLQCGYRQCNAEEFSCADGRCLLNTQWQCDGDFDCTDHSDEAPINPKCKSAEQSCNSSFFMCKNGRCIPSGALCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSLGFPCSQQCINTYGTYKCLCTDGYEIQPANPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIGIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPRAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNHRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLINSWHAITDIQVYHSYRQPDVFKHLCTINNGGCSHLCLLAPGKSHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFKCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDEKDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFQCSNGQCISAKWKCDGHEDCKYGEDEKNCEPASPTCSSSEYICASGGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCRNKAHCIPIRWLCDGIHDCVDGSDEENCDRGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCDKFLCPPTRPHRCRNNRICLQPEQMCNGIDDCGDNSDEDPCGGKLTYKARPCKKDEFACSNKKCIPVDLQCDQLDDCGDGSDEQGCRITPSEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINTEGSYKCVCHQNFQERNNTCIAKGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIPGREKRQANSGLICPEFRRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLSGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDHFSERIYWADLELSVIGSVLYDGSDSVVSVTSKQGLLHPHRIDVFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNVDKTKGVLISHRYKQLDLPNPCSDLACEFLCLLNPSGATCACPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEINHCSNYCQNGGTCMPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCSVTAGNQPYCHCQPEHTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPIRYEGSKCEIDKCIRCHGGHCIINKDSEDISCNCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHNDGGLLDPGFMVDPAKARYIGGGSSVFKLPHTAPPIYLNSDLKGPLTAGPTNYSNPVYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA", "length": 4596, "header": "tr|F1MKZ6-1|F1MKZ6_BOVIN Isoform 1 of Low-density lipoprotein receptor-related protein 1B OS=Bos taurus OX=9913 GN= PE=3 SV=4 CANONICAL=F1MKZ6-1" }, "isoforms": [ { "isoform_ac": "F1MKZ6-1", "url": "https://www.uniprot.org/uniprotkb/F1MKZ6/entry", "sequence": { "sequence": "MSEFLLALLTLSGLLPVAKVLTMGADRDQQSCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVETKCPWNHIACLGANKCIHLSQLCNGVLDCLDGYDEGVHCRELLPNCQQLNCQHKCAMVRNSTMCYCEDGFEIKEDGRSCKDQDECAIYGTCSQSCVNTYGSYACSCVEGYIMQPDNRSCKAKNEPTDKPPLLLIANSETIEIFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNRLKCIQITKTGRLTDEWTISILQSFHNVQQMAIDWLTRNLYFVDHVSDRIFVCDYNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKWVYWVDLYLDYVEVVDYQGKNRHTIIQGRQVKHLYGITVFEDYLYATDADNFNIIRINRFNGSDIHSLIKMENAKAIRIYQKRIQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETSYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVSGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTHTLYWCDAYYDHIEKVFLNGTHRKIVYSGKELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITNEVTLLRRERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTNCIFNPGEVLPQICKAGEFRCRNRHCIQARWKCDGDDDCLDGSDEDSLSCYNHSCPDDQFKCKNNRCIPKRWLCDGANDCGSNEDESNQTCSARTCEVDQFSCGNGRCIPRAWLCDREDDCGDHTDEIASCEFPTCEPLTQFICKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFSCSSGRCIPGHWACDGDNDCGDFSDEINCTREEIHSPAGCNANEFQCHPDGNCIPDVWHCDGEKDCEDGSDEKGCNGTLRLCDHKTKFSCRSTGRCISKAWVCDGDIDCEDQSDEDDCDNFLCGPPKYPCANDTSVCLQPEKLCNGRWDCPDGSDEGDLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLGRDNKTCEIVDYCSNHLKCSQVCEQHKQTVKCSCYEGWKLDVDGQSCSSVDPFEAFIIFSIRHEIRKIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRFGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTSMIEIIRGHEYLSHPFAVSLYGSDVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGRGPCSHMCLINHNRSAACACPHLMKLSSNKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLTVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGSNLEVIETMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTVLRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCRGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAIDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIALHPEKGYLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDFEENKLYWCDARTDKIERIDLETGGNREMVLSGNNVDMFSVAVFGAYIYWSDRAHANGSIRRGHKNDATETVTMRTGLGVNLKEVKIFNRVREKGTNVCAKNNGGCQQLCLYRGNSWRTCACAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRKGSNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVIAMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDHRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNIYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCVPHSKLCDGENDCGDNSDELDCKVSTCAAVEFRCTDGMCIPRSARCNQNIDCADASDEKNCNNTDCTYFYKLGVKTTGFIRCNSTSLCVLPAWICDGSNDCGDYSDELKCPVQNKHKCEENYFGCPSGRCILNTWVCDGQKDCEDGLDEFHCDASCSWNQFACSTEKCISKHWICDGEDDCEDGLDESDSICGTITCAADMFSCQGSRACVPRHWLCDGERDCPNGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESLQCGYRQCNAEEFSCADGRCLLNTQWQCDGDFDCTDHSDEAPINPKCKSAEQSCNSSFFMCKNGRCIPSGALCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSLGFPCSQQCINTYGTYKCLCTDGYEIQPANPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIGIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPRAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNHRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLINSWHAITDIQVYHSYRQPDVFKHLCTINNGGCSHLCLLAPGKSHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFKCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDEKDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFQCSNGQCISAKWKCDGHEDCKYGEDEKNCEPASPTCSSSEYICASGGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCRNKAHCIPIRWLCDGIHDCVDGSDEENCDRGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCDKFLCPPTRPHRCRNNRICLQPEQMCNGIDDCGDNSDEDPCGGKLTYKARPCKKDEFACSNKKCIPVDLQCDQLDDCGDGSDEQGCRITPSEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINTEGSYKCVCHQNFQERNNTCIAKGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIPGREKRQANSGLICPEFRRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLSGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDHFSERIYWADLELSVIGSVLYDGSDSVVSVTSKQGLLHPHRIDVFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNVDKTKGVLISHRYKQLDLPNPCSDLACEFLCLLNPSGATCACPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEINHCSNYCQNGGTCMPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCSVTAGNQPYCHCQPEHTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPIRYEGSKCEIDKCIRCHGGHCIINKDSEDISCNCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHNDGGLLDPGFMVDPAKARYIGGGSSVFKLPHTAPPIYLNSDLKGPLTAGPTNYSNPVYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA", "length": 4596, "header": "tr|F1MKZ6-1|F1MKZ6_BOVIN Isoform 1 of Low-density lipoprotein receptor-related protein 1B OS=Bos taurus OX=9913 GN= PE=3 SV=4 CANONICAL=F1MKZ6-1" }, "locus": { "chromosome": "2", "start_pos": 56786411, "end_pos": 54612052, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000034302.7", "url": "https://www.ensembl.org/id/ENSBTAT00000034302.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000034199.6", "url": "https://www.ensembl.org/id/ENSBTAP00000034199.6" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1MKZ6", "url": "https://www.uniprot.org/uniprotkb/F1MKZ6" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "F1MKZ6", "url": "https://www.uniprot.org/uniprotkb/F1MKZ6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MKZ6", "url": "https://www.uniprot.org/uniprotkb/F1MKZ6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "receptor-mediated endocytosis", "id": "GO:0006898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "database": "UniProtKB", "id": "F1MKZ6", "url": "https://www.uniprot.org/uniprotkb/F1MKZ6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1039, "end_pos": 1041, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1087, "end_pos": 1089, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1143, "end_pos": 1145, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1207, "end_pos": 1209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1296, "end_pos": 1298, "annotation": "n_glycosylation_sequon" }, { "start_pos": 134, "end_pos": 136, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1500, "end_pos": 1502, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1547, "end_pos": 1549, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1634, "end_pos": 1636, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1752, "end_pos": 1754, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1814, "end_pos": 1816, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1919, "end_pos": 1921, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1981, "end_pos": 1983, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2103, "end_pos": 2105, "annotation": "n_glycosylation_sequon" }, { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2455, "end_pos": 2457, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2485, "end_pos": 2487, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2504, "end_pos": 2506, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2546, "end_pos": 2548, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2623, "end_pos": 2625, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2644, "end_pos": 2646, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2786, "end_pos": 2788, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2799, "end_pos": 2801, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2889, "end_pos": 2891, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3031, "end_pos": 3033, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3063, "end_pos": 3065, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3073, "end_pos": 3075, "annotation": "n_glycosylation_sequon" }, { "start_pos": 313, "end_pos": 315, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3161, "end_pos": 3163, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3307, "end_pos": 3309, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3313, "end_pos": 3315, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3679, "end_pos": 3681, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3874, "end_pos": 3876, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3891, "end_pos": 3893, "annotation": "n_glycosylation_sequon" }, { "start_pos": 3903, "end_pos": 3905, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4014, "end_pos": 4016, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4201, "end_pos": 4203, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4378, "end_pos": 4380, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4417, "end_pos": 4419, "annotation": "n_glycosylation_sequon" }, { "start_pos": 443, "end_pos": 445, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4553, "end_pos": 4555, "annotation": "n_glycosylation_sequon" }, { "start_pos": 725, "end_pos": 727, "annotation": "n_glycosylation_sequon" }, { "start_pos": 758, "end_pos": 760, "annotation": "n_glycosylation_sequon" }, { "start_pos": 829, "end_pos": 831, "annotation": "n_glycosylation_sequon" }, { "start_pos": 883, "end_pos": 885, "annotation": "n_glycosylation_sequon" }, { "start_pos": 919, "end_pos": 921, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MKZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MKZ6" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 3841, "end_pos": 3878, "start_aa": "Asp", "end_aa": "Ile", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1039, "end_pos": 1041 }, { "start_pos": 1087, "end_pos": 1089 }, { "start_pos": 1143, "end_pos": 1145 }, { "start_pos": 1207, "end_pos": 1209 }, { "start_pos": 1296, "end_pos": 1298 }, { "start_pos": 134, "end_pos": 136 }, { "start_pos": 1500, "end_pos": 1502 }, { "start_pos": 1547, "end_pos": 1549 }, { "start_pos": 1634, "end_pos": 1636 }, { "start_pos": 1752, "end_pos": 1754 }, { "start_pos": 1814, "end_pos": 1816 }, { "start_pos": 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"end_pos": 3905 }, { "start_pos": 4014, "end_pos": 4016 }, { "start_pos": 4201, "end_pos": 4203 }, { "start_pos": 4378, "end_pos": 4380 }, { "start_pos": 4417, "end_pos": 4419 }, { "start_pos": 443, "end_pos": 445 }, { "start_pos": 4553, "end_pos": 4555 }, { "start_pos": 725, "end_pos": 727 }, { "start_pos": 758, "end_pos": 760 }, { "start_pos": 829, "end_pos": 831 }, { "start_pos": 883, "end_pos": 885 }, { "start_pos": 919, "end_pos": 921 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1ML13-1", "uniprot_ac": "F1ML13", "uniprot_id": "F1ML13_BOVIN", "mass": { "chemical_mass": 120361.0, "monoisotopic_mass": 120361.0 }, "refseq": { "ac": "XP_002696487", "name": "semaphorin-5A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696487" }, "gene_names": [ { "name": "SEMA5A", "type": "recommended", "evidence": [ { "id": "F1ML13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML13" } ] }, { "name": "SEMA5A", "type": "synonym", "evidence": [ { "id": "XP_002696487", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696487" } ] } ], "protein_names": [ { "name": "Semaphorin-5A", "type": "recommended", "evidence": [ { "id": "F1ML13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML13/entry#names_and_taxonomy" } ] }, { "name": "Semaphorin-F", "type": "synonym", "evidence": [ { "id": "F1ML13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML13/entry#names_and_taxonomy" } ] }, { "name": "semaphorin-5A", "type": "synonym", "evidence": [ { "id": "XP_002696487", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696487" } ] } ], "function": [ { "annotation": "Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "F1ML13", "url": "https://www.uniprot.org/uniprotkb/F1ML13#function" }, { "database": "UniProtKB", "id": "ARBA00056685", "url": "https://www.uniprot.org/uniprotkb/ARBA00056685#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1ML13", "url": "https://www.uniprot.org/uniprotkb/F1ML13" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SEMA5A", "url": "https://www.uniprot.org/uniprotkb/F1ML13", "locus": { "chromosome": "20", "start_pos": 64217208, "end_pos": 63790828, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000005021", "url": "https://www.ensembl.org/id/ENSBTAG00000005021" } ] } } ], "crossref": [ { "id": "F1ML13", "url": "https://alphafold.ebi.ac.uk/entry/F1ML13", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000005021", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000005021", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11263", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11263", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "506636", "url": "https://www.ncbi.nlm.nih.gov/gene/506636", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057563", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057563", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:506636", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506636", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "YHTRSTC", "url": "https://omabrowser.org/oma/group/YHTRSTC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1ML13", "url": "https://www.orthodb.org/?gene=F1ML13", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11036", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11036:SF78", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036:SF78", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00090", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00090", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01403", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01403", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF01437", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01437", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23260", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23260", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-416700", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416700", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-5173214", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "XP_002696487", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696487", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1ML13", "url": "https://www.uniprot.org/uniprotkb/F1ML13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML13-1", "url": "https://www.uniprot.org/uniprotkb/F1ML13-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGPCVIAWLFSSLGWWRLAQLETDASLCQRAEHPVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAAEWECDEATKKACYSKGKSQEECQNYIRVLLVGGDRLFTCGTNAFTPVCTNRTLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYHELQGTFFLPELDLIYGIFTTNVNSIAASAVCIFNLSAISQAFNGPFKYQENSRSAWLPYPNPNPNFQCGTVDQGVYMNLTERNLQDAQKFILMHEVVQPVSPVPAFMEDSSRFSHVAVDVVQARDALVHVIYLATDYGTIKKVRAPLTQTSGGCVLEEMELFPERRPEPVRSLRILHSQSVLFAGLREHVAKIPLKRCQFYRSRSACIGAQDPYCGWDLVMKKCTSLEESLSMTQWEQSIATCPVRNLTVDGHFGAWSPWTPCTHMDGSAVGSCLCRTRSCDSPAPQCGGWQCQGPRMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHVFWTGWGPWERCTAQCGGGIQARRRTCENGPDCAGCNVEYQPCNTNPCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLPDPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKFGGMPCLGPSLEYQECNILPCPVDGMWSCWSSWSTCSATCGGGHYMRTRSCTNPAPAYGGDICLGLHTEEALCNTQPCPESWSEWSEWSECDVAGVQVRVRQCVLLFPVGSQCSGNTTESRPCIFDSNFIPEVSVARSSSIEEKRCGEFNLFHMIAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVAPAPLNTSITNHINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY", "length": 1073, "header": "tr|F1ML13-1|F1ML13_BOVIN Isoform 1 of Semaphorin-5A OS=Bos taurus OX=9913 GN=SEMA5A PE=4 SV=3 CANONICAL=F1ML13-1" }, "isoforms": [ { "isoform_ac": "F1ML13-1", "url": "https://www.uniprot.org/uniprotkb/F1ML13/entry", "sequence": { "sequence": "MKGPCVIAWLFSSLGWWRLAQLETDASLCQRAEHPVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAAEWECDEATKKACYSKGKSQEECQNYIRVLLVGGDRLFTCGTNAFTPVCTNRTLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYHELQGTFFLPELDLIYGIFTTNVNSIAASAVCIFNLSAISQAFNGPFKYQENSRSAWLPYPNPNPNFQCGTVDQGVYMNLTERNLQDAQKFILMHEVVQPVSPVPAFMEDSSRFSHVAVDVVQARDALVHVIYLATDYGTIKKVRAPLTQTSGGCVLEEMELFPERRPEPVRSLRILHSQSVLFAGLREHVAKIPLKRCQFYRSRSACIGAQDPYCGWDLVMKKCTSLEESLSMTQWEQSIATCPVRNLTVDGHFGAWSPWTPCTHMDGSAVGSCLCRTRSCDSPAPQCGGWQCQGPRMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHVFWTGWGPWERCTAQCGGGIQARRRTCENGPDCAGCNVEYQPCNTNPCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLPDPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKFGGMPCLGPSLEYQECNILPCPVDGMWSCWSSWSTCSATCGGGHYMRTRSCTNPAPAYGGDICLGLHTEEALCNTQPCPESWSEWSEWSECDVAGVQVRVRQCVLLFPVGSQCSGNTTESRPCIFDSNFIPEVSVARSSSIEEKRCGEFNLFHMIAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVAPAPLNTSITNHINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY", "length": 1073, "header": "tr|F1ML13-1|F1ML13_BOVIN Isoform 1 of Semaphorin-5A OS=Bos taurus OX=9913 GN=SEMA5A PE=4 SV=3 CANONICAL=F1ML13-1" }, "locus": { "chromosome": "20", "start_pos": 64216204, "end_pos": 63856472, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000074691.3", "url": "https://www.ensembl.org/id/ENSBTAT00000074691.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000064595.1", "url": "https://www.ensembl.org/id/ENSBTAP00000064595.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:506636", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:506636", "resource": "KEGG Pathway" }, { "id": "R-BTA-416700", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-416700", "resource": "Reactome", "description": "Other semaphorin interactions" }, { "id": "R-BTA-5173214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "resource": "Reactome", "description": "O-glycosylation of TSR domain-containing proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZTD8-1", "protein_name": "Semaphorin-5A", "gene_name": "Sema5a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKGACILAWLFSSLGVWRLARPETQDPAKCQRAEHPVVSYKEIGPWLREFRAENAVDFSRLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVQWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTIRSLSNLTEIHDQISGMARCPYSPQHNSTALLTASGELYAATAMDFPGRDPAIYRSLGTLPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLPYPNPNPNFQCGTMDQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGRDTLVHIIYLATDYGTIKKVRAPLSQSSGSCLLEEIELFPERKSEPIRSLKILHSQSVLFVGLQEHVVKIPLKRCHFHQTRGACIGAQDPYCGWDAVMKKCTSLEESLSMTQWDQSVPTCPTRNLTVDGSFGPWSPWTPCTHTDGTAVGSCLCRSRSCDSPAPQCGGWQCEGPRMEITNCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHVFWTGWGPWERCTAQCGGGIQARRRTCENGPDCAGCNVEYQPCNTNACPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLPDPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEFQECNILPCPVDGVWSCWSSWSKCSATCGGGHYMRTRSCTNPAPAYGGDICLGLHTEEALCNTQTCPENWSEWSEWSVCDASGTQVRTRQCILLFPVGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMMAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAALNSSITNHINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY", "length": 1074 }, "evidence": [ { "id": "F1ML13", "url": "https://omabrowser.org/oma/group/F1ML13/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1R9L1-1", "protein_name": "Semaphorin-5A isoform X1", "gene_name": "sema5a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAEGRPLARGLVLLHSLLLLMPRGVPCRGAIRALESPCHRAEHPLISHTDIEPWIHRFRAEGTVDYSQLTFDPGQNELIVGARNHLFRLHLEDLSLIQEAEWHCDEFTKGACFSRGKSEEECQNYIRVLLVNGDRLFTCGTNAFTPICTNRTLTNLTEVHDQISGMARCPYNPLHNSTALITSSGELYAATAMDFSGRDPAIYRSLGGLPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGRTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEIPFNYNELQGTFFLPELELLYGIFTTNVNSIAASAVCAFNLSAITQVFSGPFKYQENSRSAWLPYPNPNPDFQCGTIDFGSYVNLTERNLQDAQKFILMHEVVQPVVPVPYFMEDNVRFSHVAVDVVQGKDMLYHIIYLATDYGTIKKVLSPLNQTTGSCLLDEIELFPLKKRQPIRSLLILHSHSELFVGVREQVIKIPLMRCNFHKSREACVGARDPYCGWDLVLKKCTTLEESVSMSQWEQSITRCPVRNVTVDGHYGAWSGWKTCSHSDGGSVGSCQCRTRACDSPSPQCGGQPCQGISVEVANCSRNGAWTPWTAWAPCSTSCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLPCPPHVYWSAWSPWERCTVPCGGGIQSRRRTCENGNECPGCSTEFQSCNTLPCPDLKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARVPEPGLLEVGRQRIEMRYCSSDGSTGCSTDGDLLRSGRITGLTVNGGWSVWGPWSQCSRDCSSGVRNRKRTCSNPKPKYGGITCLGPAQEFQECNTTPCPVDGSWSCWSPWSKCSVTCGGGHYMRTRSCNNPPPAYGGDICLGLHTEEALCNIQPCPESWSDWSEWSPCDSSGSQVRLRHCDVLFPTGNQCSGNSSETRACLPISNFIPETSVARSSQEERWCGDFNVFHMIAVGLSSSILGCLVTLLVYTYCQRYQQQSHDATVIHPISAAPLNTSISNHINKLDKYDSVEAIKAFNKNNLILEERNKYFNPQLAGKTYTNAYFTDVNTYDDF", "length": 1078 }, "evidence": [ { "id": "F1ML13", "url": "https://omabrowser.org/oma/group/F1ML13/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q13591-1", "protein_name": "Semaphorin-5A", "gene_name": "SEMA5A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKGTCVIAWLFSSLGLWRLAHPEAQGTTQCQRTEHPVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLSMTQWEQSISACPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNPCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCPESWSEWSDWSECEASGVQVRARQCILLFPMGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMIAVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAPLNTSITNHINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY", "length": 1074 }, "evidence": [ { "id": "F1ML13", "url": "https://omabrowser.org/oma/group/F1ML13/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GFU3-1", "protein_name": "Semaphorin-5A", "gene_name": "SEMA5A", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MTTMKGSCLLVLLLAGFGVLGILEPDAEDIHCHRAVHPVITYKEIAPWLHVFKAEDAVDFSQLTFDPGQKELIAGARNYLFRLQLEDLSLIQAVEWQCDEATKRACYSKGKSKEECQNYIRVLLVGGNHLFTCGTNAFTPICTNRTLNNLTEIHDQISGMARCPYSPQHNSTALLTSSGELYAATAMDFPGRDPAIYRSLGALPPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGKFVLEDTWTTFMKARLNCSRPGEIPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAITQAFNGPFKYQENSRSAWLPYPNPNPNFQCGTMDQGLYVNLTERNLQDAQKFFLMHEVVQPVIPIPYFMEDNSRFSHVVVDVVQGKDMLFHIIYLATDYGTIKKVLAPMNQTSSSCLLEEIELLPKSQREPIRSLQILHSQSVLFVGLQEHVIKVPLKRCLFYKTFSACIGSQDPYCGWDMVMKKCTTLEESLSMSQWEQSITVCPTRNLTVDGHFGTWSQWKPCSHTDGASTGSCLCRTRVCDSPAPQCGGWLCEGPTMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHVFWTSWGPWERCTAQCGGGIQARRRTCENGPDCPGCSVEYQPCNTNACPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLPDPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRSGRYSAHTINGAWSPWSAWSQCSRDCSRGIRNRKRVCSNPEPKYGGLPCLGPSLEYQECNILPCPVDGGWSCWSSWSKCSATCGGGHYMRTRSCTNPAPAYGGDICLGLHTEEALCNTQPCPDSWSEWSEWSECDSSGMQLRVRQCILLFPVGSQCTGNTTESRACAFDSNFIPEISVARSSSREEKRCGEFNMFHMIAVGLSSSILGCLLTLLIYTYCQRYQQQSHDATVIHPVSPAPLNTSITNHINKLDKYDSVEAIKAFNKNNLILEERNKYFNPHLTAKTYSNTYFTDFNNYDEY", "length": 1076 }, "evidence": [ { "id": "F1ML13", "url": "https://omabrowser.org/oma/group/F1ML13/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1ML13", "url": "https://www.uniprot.org/uniprotkb/F1ML13" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "semaphorin receptor binding", "id": "GO:0030215", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030215", "evidence": [ { "database": "UniProtKB", "id": "F1ML13", "url": "https://www.uniprot.org/uniprotkb/F1ML13" } ], "pmid": "" }, { "name": "chemorepellent activity", "id": "GO:0045499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045499", "evidence": [ { "database": "UniProtKB", "id": "F1ML13", "url": "https://www.uniprot.org/uniprotkb/F1ML13" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "F1ML13", "url": "https://www.uniprot.org/uniprotkb/F1ML13" } ], "pmid": "" }, { "name": "semaphorin-plexin signaling pathway", "id": "GO:0071526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071526", "evidence": [ { "database": "UniProtKB", "id": "F1ML13", "url": "https://www.uniprot.org/uniprotkb/F1ML13" } ], "pmid": "" }, { "name": "neural crest cell migration", "id": "GO:0001755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001755", "evidence": [ { "database": "UniProtKB", "id": "F1ML13", "url": "https://www.uniprot.org/uniprotkb/F1ML13" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "F1ML13", "url": "https://www.uniprot.org/uniprotkb/F1ML13" } ], "pmid": "" }, { "name": "axon extension", "id": "GO:0048675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048675", "evidence": [ { "database": "UniProtKB", "id": "F1ML13", "url": "https://www.uniprot.org/uniprotkb/F1ML13" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1014, "end_pos": 1016, "annotation": "n_glycosylation_sequon" }, { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 226, "end_pos": 228, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 322, "end_pos": 324, "annotation": "n_glycosylation_sequon" }, { "start_pos": 366, "end_pos": 368, "annotation": "n_glycosylation_sequon" }, { "start_pos": 535, "end_pos": 537, "annotation": "n_glycosylation_sequon" }, { "start_pos": 590, "end_pos": 592, "annotation": "n_glycosylation_sequon" }, { "start_pos": 716, "end_pos": 718, "annotation": "n_glycosylation_sequon" }, { "start_pos": 932, "end_pos": 934, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1ML13-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1073, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1ML13-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ML13" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1ML13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML13" }, { "id": "PS51004", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51004" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Sema", "eco_id": "ECO_0000259", "start_pos": 34, "end_pos": 483, "start_aa": "His", "end_aa": "Leu", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1014, "end_pos": 1016 }, { "start_pos": 141, "end_pos": 143 }, { "start_pos": 146, "end_pos": 148 }, { "start_pos": 167, "end_pos": 169 }, { "start_pos": 226, "end_pos": 228 }, { "start_pos": 276, "end_pos": 278 }, { "start_pos": 322, "end_pos": 324 }, { "start_pos": 366, "end_pos": 368 }, { "start_pos": 535, "end_pos": 537 }, { "start_pos": 590, "end_pos": 592 }, { "start_pos": 716, "end_pos": 718 }, { "start_pos": 932, "end_pos": 934 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1ML32-1", "uniprot_ac": "F1ML32", "uniprot_id": "F1ML32_BOVIN", "mass": { "chemical_mass": 97982.0, "monoisotopic_mass": 97982.0 }, "refseq": {}, "gene_names": [ { "name": "SCARF1", "type": "recommended", "evidence": [ { "id": "F1ML32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML32" } ] } ], "protein_names": [ { "name": "Scavenger receptor class F member 1", "type": "recommended", "evidence": [ { "id": "F1ML32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML32/entry#names_and_taxonomy" } ] }, { "name": "Acetyl LDL receptor", "type": "synonym", "evidence": [ { "id": "F1ML32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML32/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth.", "evidence": [ { "database": "UniProtKB", "id": "F1ML32", "url": "https://www.uniprot.org/uniprotkb/F1ML32#function" }, { "database": "UniProtKB", "id": "ARBA00058330", "url": "https://www.uniprot.org/uniprotkb/ARBA00058330#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1ML32", "url": "https://www.uniprot.org/uniprotkb/F1ML32" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SCARF1", "url": "https://www.uniprot.org/uniprotkb/F1ML32", "locus": { "chromosome": "19", "start_pos": 22737996, "end_pos": 22749418, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000011483", "url": "https://www.ensembl.org/id/ENSBTAG00000011483" } ] } } ], "crossref": [ { "id": "F1ML32", "url": "https://alphafold.ebi.ac.uk/entry/F1ML32", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000011483", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000011483", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00055", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00055", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "616566", "url": "https://www.ncbi.nlm.nih.gov/gene/616566", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002049", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002049", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR057138", "url": "https://www.ebi.ac.uk/interpro/entry/IPR057138", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:616566", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616566", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "CFHGNCH", "url": "https://omabrowser.org/oma/group/CFHGNCH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1ML32", "url": "https://www.orthodb.org/?gene=F1ML32", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24043", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24043", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24043:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24043:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00053", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00053", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23301", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23301", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1ML32", "url": "https://www.uniprot.org/uniprotkb/F1ML32", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML32-1", "url": "https://www.uniprot.org/uniprotkb/F1ML32-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDSHGSPARLSWDPELTASSSCRLQIQTSPEASTQPSPLAFPFPFTILVSASQRLPTVSGRCLMAARPSSLVSSGKAWGGSRKGVGRCGGQTDPSPPAALAAMGPGLLFPLLLLEALGAPGSELDAGGRHVCKASSPSAELQCCPGWRRKDRECTIPICEGLDACREDEVCVKPGLCRCKPGFFGAQCNSRCPGQYWGPDCREVCACHPHGQCEPATGVCHCQPDRWGDRCEFPCACGPHGRCNPETGACRCEPGWWSPTCRRPCQCNPAAARCDQATGSCLCEPGWWGRRCSFRCACHGSPCAQESGRCACRPGWWGPECRQPCECVRGRCSAVSGQCSCPPGFQGVRCELPCPAGQYGLRCRDSCGHCKQNKPCSADTGSCEACKPGWNGTQCHQPCPPGTFGENCSQQCPHCRLGEACQPDTGHCQRCEPGWRGPRCEDPCLIGTFGEGCGSTCPTCVQGACDAVTGECVCNAGYWGPSCNTSCPSGFHGNNCSVPCECPEGNCDPVSGACQLGSHSQDAALIAGILVPLLLLLLAIACCACCCWAARLDPKDRPVRDGTAMSRMKLRVWGALTSSLGSALPCGPLSSHKLPWVTVSHHDPEIPFNHSFIEPPSAGWASDDSFSSDSESGEEDEGPAYCVPPQEGMVPAVPAESSEASLAGGPFPPPEDASTPFAIPRTSSLARAKRPSVSFAEGTKFAPQSRRGSGELSSPLRKPKRLSRGTQPGPESQETEESTGPQVETDGAPPGTASPRDSAVGRRRLPLGGRTVAERVEAIEGSVQESSGSVTTIYMLAGTPRGPEGPVRSVLRRFGSFQKGQAEPKVKSAIPKPPRRALSRNKDSPRLDSGSANQSPSSAMKEELTGALESSGTGSEEGARSLGGSIKSSEGGQELAPEDGSLVQDPQKVADKEGQEEPQYENVVPISGPLEP", "length": 932, "header": "tr|F1ML32-1|F1ML32_BOVIN Isoform 1 of Scavenger receptor class F member 1 OS=Bos taurus OX=9913 GN=SCARF1 PE=4 SV=2 CANONICAL=F1ML32-1" }, "isoforms": [ { "isoform_ac": "F1ML32-1", "url": "https://www.uniprot.org/uniprotkb/F1ML32/entry", "sequence": { "sequence": "MDSHGSPARLSWDPELTASSSCRLQIQTSPEASTQPSPLAFPFPFTILVSASQRLPTVSGRCLMAARPSSLVSSGKAWGGSRKGVGRCGGQTDPSPPAALAAMGPGLLFPLLLLEALGAPGSELDAGGRHVCKASSPSAELQCCPGWRRKDRECTIPICEGLDACREDEVCVKPGLCRCKPGFFGAQCNSRCPGQYWGPDCREVCACHPHGQCEPATGVCHCQPDRWGDRCEFPCACGPHGRCNPETGACRCEPGWWSPTCRRPCQCNPAAARCDQATGSCLCEPGWWGRRCSFRCACHGSPCAQESGRCACRPGWWGPECRQPCECVRGRCSAVSGQCSCPPGFQGVRCELPCPAGQYGLRCRDSCGHCKQNKPCSADTGSCEACKPGWNGTQCHQPCPPGTFGENCSQQCPHCRLGEACQPDTGHCQRCEPGWRGPRCEDPCLIGTFGEGCGSTCPTCVQGACDAVTGECVCNAGYWGPSCNTSCPSGFHGNNCSVPCECPEGNCDPVSGACQLGSHSQDAALIAGILVPLLLLLLAIACCACCCWAARLDPKDRPVRDGTAMSRMKLRVWGALTSSLGSALPCGPLSSHKLPWVTVSHHDPEIPFNHSFIEPPSAGWASDDSFSSDSESGEEDEGPAYCVPPQEGMVPAVPAESSEASLAGGPFPPPEDASTPFAIPRTSSLARAKRPSVSFAEGTKFAPQSRRGSGELSSPLRKPKRLSRGTQPGPESQETEESTGPQVETDGAPPGTASPRDSAVGRRRLPLGGRTVAERVEAIEGSVQESSGSVTTIYMLAGTPRGPEGPVRSVLRRFGSFQKGQAEPKVKSAIPKPPRRALSRNKDSPRLDSGSANQSPSSAMKEELTGALESSGTGSEEGARSLGGSIKSSEGGQELAPEDGSLVQDPQKVADKEGQEEPQYENVVPISGPLEP", "length": 932, "header": "tr|F1ML32-1|F1ML32_BOVIN Isoform 1 of Scavenger receptor class F member 1 OS=Bos taurus OX=9913 GN=SCARF1 PE=4 SV=2 CANONICAL=F1ML32-1" }, "locus": { "chromosome": "19", "start_pos": 22749219, "end_pos": 22739000, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000015261.5", "url": "https://www.ensembl.org/id/ENSBTAT00000015261.5" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000015261.4", "url": "https://www.ensembl.org/id/ENSBTAP00000015261.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:616566", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:616566", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZRK9-1", "protein_name": "Scavenger receptor class F, member 1", "gene_name": "Scarf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLTAMGLGLVFSLLLFWTREIQGSTLDPAGQHVCIGSSPSELQCCSGWRQKDQECTIPICEGPDACKKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRETCPCHPRGQCEPATGVCQCQPNYWGKLCEFPCTCGPHGKCDPKTGLCHCDPGWWSPTCRRPCQCNPLARCDQVTGACICPTGWWGHRCSFSCNCHTSPCLQDSGRCTCLQGWWGPECSRRCQCVRGQCSVTSGHCSCPPGFQGALCELPCKPGRYGAQCKESCGHCEPNATCSPVTGNCESCKPGWNGTQCKQPCPPGTFGERCTGKCPRCRLEEPCQVETGHCQRCDPGWLGHRCEKPCPLGTFGKGCSSTCPACVQGTCNAVTGECVCSAGYWGTSCNSSCPSGFHGNNCSMPCQCPEGLCHPESGACQLGPHGKNALIVGILVPLLLLLMGIICCVYCCSASRLDPKDRPERNGAAFFRMKQQVWGALTSLGSALPCGSLSNYKLPWVTVSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPDSGEEDEAHAYFMPPREETVPMTQEESPAASLPGGPFPPPEDASTPFPIPRTSSLARAKRPSVSFAEGTKFAPQNGRSSGDLSSPIRKPKRLSRGAQPRPEGQEAEESTGPEQENPEEDVPTATSSGDAATSHGQLPPGSRTVTECVETTDGGIQESSGSVATIYMLAGTPQKPEGPVWSVFRRLGNYQKDQAAPKVKSAIPKPLRRSLGRNQASSGLSQSSGSAPGAVLSGAMESTAVKPEEASRGLGDGIESLGTVQEPVVGSSSPEQGSQKQAEEQEQEEPLYENVVPMLQH", "length": 823 }, "evidence": [ { "id": "F1ML32", "url": "https://omabrowser.org/oma/group/F1ML32/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7FBT2-1", "protein_name": "Scavenger receptor class F member 1", "gene_name": "scarf1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDTFLTSFGLMLMCVQYSAQRLSLTGKNVCLSVRDSSAICCSGWGQSGDECTVPLCEGERACLQDEVCVYPGLCRCKAGFYGYQCKAPCPPEFWGPDCREFCPCHPHGLCDPATGVCSCLPNRWGSLCQNSCKCGRHGKCDPVYGNCTCEEGWWTSTCSKACQCHLATSTCDQATGRCICNEGYWGQKCSLPCNCYVSPCQQRTGTCQCLHGWWGPSCDRRCICNLNNADCDVQTGGCLCYPGYKEPFCNEPCDSGKYGRGCKNSCGRCEGGRPCSKLDGLCDACEPGWNGTRCDQRCPAGYYGHRCQEICPHCRNMDPCDPETGACLQCNPGWTGPRCDKPCTDGRYGDGCRFLCKTCNHGHCDHVTGRCICLPGFQGESCNSTCPFNLYGFNCSSTCDCGSQACHPATGACPNSSRAGLLAGLLIPLCILILALLFCCCCCGRPVEGKERVTVGDGSPAVRMKHHVYTVLANMGSAMPCITLWSSGLPRVTVSHHDPELTFNHSFIEQPSSGWVIDSFETDEDGEAVYCEPPREDVLTEAGGELQELNSKCNFFPDPSTFSSEDMSQAFGIPRTSSIAKSKRPSVSFAEGTKFSPKERRSSTQDLQGTARKPKPWGVLMISALQGGQGNQNNETETEKEEKNDEENISEEQRASSETLQNDSERYSSGPQRTHLTVPGGRRRTLSNPKKNIQSSDGGQDADSEKLTTVYVTVGKTSKMVKQEPPSEGPVQAMLRRLGSLQRQKEEVAKGKAQSIVKPPRRKLGARASAWEQASGSGQSEVVMRKPSRKKHSSLSSPCIVGAIDSPQENSAPKRPLSSILKSVPESDPFQSLEVEPNSEETGIQTEHTYETVALPDTVSTSSEIIINDTVMDQAENEPNYENVYLKH", "length": 888 }, "evidence": [ { "id": "F1ML32", "url": "https://omabrowser.org/oma/group/F1ML32/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q14162-1", "protein_name": "Scavenger receptor class F member 1", "gene_name": "SCARF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGLGLLLPLLLLWTRGTQGSELDPKGQHVCVASSPSAELQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRCSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRDTALIAGSLVPLLLLFLGLACCACCCWAPRSDLKDRPARDGATVSRMKLQVWGTLTSLGSTLPCRSLSSHKLPWVTVSHHDPEVPFNHSFIEPPSAGWATDDSFSSDPESGEADEVPAYCVPPQEGMVPVAQAGSSEASLAAGAFPPPEDASTPFAIPRTSSLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQSGPEGREAEESTGPEEAEAPESFPAAASPGDSATGHRRPPLGGRTVAEHVEAIEGSVQESSGPVTTIYMLAGKPRGSEGPVRSVFRHFGSFQKGQAEAKVKRAIPKPPRQALNRKKGSPGLASGSVGQSPNSAPKAGLPGATGPMAVRPEEAVRGLGAGTESSRRAQEPVSGCGSPEQDPQKQAEEERQEEPEYENVVPISRPPEP", "length": 830 }, "evidence": [ { "id": "F1ML32", "url": "https://omabrowser.org/oma/group/F1ML32/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5ND28-1", "protein_name": "Scavenger receptor class F member 1", "gene_name": "Scarf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLAAMGLELVFSLLLLWTQGTQGSTLDPAGQHVCKGSSPSELQCCPGWRQKDQECTIPICEGPDACRKEEVCVKPGLCRCKPGFFGAQCSSRCPGQYWGHDCRETCPCHPRGQCEPATGDCQCQPNYWGRLCEFPCTCGPHGQCDPKTGLCHCDPGWWSPTCRRPCQCNPASRCDQATGTCVCPPGWWGRRCSFSCNCHTSPCMQDSGRCVCLPGWWGPECSRKCQCVRGQCSVTSGHCSCPPGFHGIRCELPCNPGHYGAQCKESCGHCELNATCSPVTGNCESCKPGWNGTQCKQPCPAGTFGERCTGQCPRCRLGEPCQAETGHCQHCDPGWLGHRCENPCPLGTFGKGCSSTCPACAQGTCDAVTGECVCSAGYWGTSCNSSCPAGFHGNNCSMPCQCPEGLCHPVSGTCQLGRHGKNALIVGILVPLLLLLMGIVCCAYCCSGTRLDPKDRPERNGAAFFRMKQQVWGALTNLGSALPCGSLSNYKLPWVTVSHHDPEVPFNHSFIEPPSAGWASDDSFSSDPDSGEEDEAHAYFVPPREEMVPMAQEESPEASLPGGSFPPPEDASTPFPIPRTSSLARAKRPSVSFAEGTKFAPQNGRSSGDLSSPIRKPKRLSRGAQPRPEGQEAEESTGPEQVNTEEDAPTATSSGDPATSHGQLPPGSQMVAECAETTDGGIQESSGSVATIYMLAGTPQKPEGPVWSVFRRLGNYQKDQMDPKVKSAIPKPLRRSLGRNQASAGSAPGAVLSQAMESTAVRPEETPRGLGDGIESSGTVQEPDAGGSSLEQDSQKQAEEKEQEEPLYENVVPMSVPPQH", "length": 820 }, "evidence": [ { "id": "F1ML32", "url": "https://omabrowser.org/oma/group/F1ML32/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "positive regulation of axon regeneration", "id": "GO:0048680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048680", "evidence": [ { "database": "UniProtKB", "id": "F1ML32", "url": "https://www.uniprot.org/uniprotkb/F1ML32" } ], "pmid": "" }, { "name": "positive regulation of neuron projection development", "id": "GO:0010976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976", "evidence": [ { "database": "UniProtKB", "id": "F1ML32", "url": "https://www.uniprot.org/uniprotkb/F1ML32" } ], "pmid": "" }, { "name": "neuron remodeling", "id": "GO:0016322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016322", "evidence": [ { "database": "UniProtKB", "id": "F1ML32", "url": "https://www.uniprot.org/uniprotkb/F1ML32" } ], "pmid": "" }, { "name": "dendrite development", "id": "GO:0016358", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016358", "evidence": [ { "database": "UniProtKB", "id": "F1ML32", "url": "https://www.uniprot.org/uniprotkb/F1ML32" } ], "pmid": "" }, { "name": "heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "id": "GO:0007157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007157", "evidence": [ { "database": "UniProtKB", "id": "F1ML32", "url": "https://www.uniprot.org/uniprotkb/F1ML32" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "scavenger receptor activity", "id": "GO:0005044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005044", "evidence": [ { "database": "UniProtKB", "id": "F1ML32", "url": "https://www.uniprot.org/uniprotkb/F1ML32" } ], "pmid": "" }, { "name": "low-density lipoprotein particle binding", "id": "GO:0030169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030169", "evidence": [ { "database": "UniProtKB", "id": "F1ML32", "url": "https://www.uniprot.org/uniprotkb/F1ML32" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1ML32", "url": "https://www.uniprot.org/uniprotkb/F1ML32" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "F1ML32", "url": "https://www.uniprot.org/uniprotkb/F1ML32" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 391, "end_pos": 393, "annotation": "n_glycosylation_sequon" }, { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" }, { "start_pos": 484, "end_pos": 486, "annotation": "n_glycosylation_sequon" }, { "start_pos": 495, "end_pos": 497, "annotation": "n_glycosylation_sequon" }, { "start_pos": 609, "end_pos": 611, "annotation": "n_glycosylation_sequon" }, { "start_pos": 853, "end_pos": 855, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1ML32-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 932, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1ML32-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ML32" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1ML32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML32" }, { "id": "PS50026", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50026" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "EGF-like", "eco_id": "ECO_0000259", "start_pos": 155, "end_pos": 189, "start_aa": "Thr", "end_aa": "Asn", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 391, "end_pos": 393 }, { "start_pos": 407, "end_pos": 409 }, { "start_pos": 484, "end_pos": 486 }, { "start_pos": 495, "end_pos": 497 }, { "start_pos": 609, "end_pos": 611 }, { "start_pos": 853, "end_pos": 855 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": 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"evidence": [ { "database": "UniProtKB", "id": "F1ML73", "url": "https://www.uniprot.org/uniprotkb/F1ML73" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "F1ML73", "url": "https://www.uniprot.org/uniprotkb/F1ML73" } ], "pmid": "" }, { "name": "defense response to virus", "id": "GO:0051607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "evidence": [ { "database": "UniProtKB", "id": "F1ML73", "url": "https://www.uniprot.org/uniprotkb/F1ML73" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "50948", "name": "", "equation": "a 2'-deoxycytidine in single-stranded DNA + H2O + H(+) = a 2'-deoxyuridine in single-stranded DNA + NH4(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1ML73-1", "Q2PT36-1", "F1MP61-1", "F1MV53-1" ], "evidence": [ { "id": "50948", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50948" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "F1ML73", "gene_name": "APOBEC3Z1", "activity": [ { "ec_number": "3.5.4.38", "activity": "a 2'-deoxycytidine in single-stranded DNA + H2O + H(+) = a 2'-deoxyuridine in single-stranded DNA + NH4(+).", "evidence": [ { "id": "F1ML73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML73" } ] }, { "ec_number": "3.5.4.38", "activity": "", "evidence": [ { "id": "F1ML73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML73" } ] } ] }, { "uniprot_ac": "F1MP61", "gene_name": "APOBEC3H", "activity": [ { "ec_number": "3.5.4.38", "activity": "a 2'-deoxycytidine in single-stranded DNA + H2O + H(+) = a 2'-deoxyuridine in single-stranded DNA + NH4(+).", "evidence": [ { "id": "F1MP61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP61" } ] }, { "ec_number": "3.5.4.38", "activity": "", "evidence": [ { "id": "F1MP61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MP61" } ] } ] }, { "uniprot_ac": "F1MV53", "gene_name": "AICDA", "activity": [ { "ec_number": "3.5.4.38", "activity": "a 2'-deoxycytidine in single-stranded DNA + H2O + H(+) = a 2'-deoxyuridine in single-stranded DNA + NH4(+).", "evidence": [ { "id": "F1MV53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV53" } ] }, { "ec_number": "3.5.4.38", "activity": "", "evidence": [ { "id": "F1MV53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MV53" } ] } ] }, { "uniprot_ac": "Q2PT36", "gene_name": "AICDA", "activity": [ { "ec_number": "3.5.4.38", "activity": "a 2'-deoxycytidine in single-stranded DNA + H2O + H(+) = a 2'-deoxyuridine in single-stranded DNA + NH4(+).", "evidence": [ { "id": "Q2PT36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PT36" } ] }, { "ec_number": "3.5.4.38", "activity": "", "evidence": [ { "id": "Q2PT36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q2PT36" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1ML73-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 185, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1ML73-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1ML73" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1ML73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML73" }, { "id": "PS51747", "database": "PROSITE", "url": "https://prosite.expasy.org/PS51747" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "CMP/dCMP-type deaminase", "eco_id": "ECO_0000259", "start_pos": 15, "end_pos": 137, "start_aa": "Trp", "end_aa": "Thr", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.5.4.38", "ec_name": "a 2'-deoxycytidine in single-stranded DNA + H2O + H(+) = a 2'-deoxyuridine in single-stranded DNA + NH4(+).", "evidence": [ { "id": "3.5.4.38", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.38" }, { "id": "3.5.4.38", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.4.38" } ] } ], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1ML88-1", "uniprot_ac": "F1ML88", "uniprot_id": "F1ML88_BOVIN", "mass": { "chemical_mass": 80326.0, "monoisotopic_mass": 80326.0 }, "refseq": {}, "gene_names": [ { "name": "PUS7", "type": "recommended", "evidence": [ { "id": "F1ML88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML88" } ] } ], "protein_names": [ { "name": "Pseudouridylate synthase 7 homolog", "type": "recommended", "evidence": [ { "id": "F1ML88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1ML88/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types.", "evidence": [ { "database": "UniProtKB", "id": "F1ML88", "url": "https://www.uniprot.org/uniprotkb/F1ML88#function" }, { "database": "UniProtKB", "id": "ARBA00053535", "url": "https://www.uniprot.org/uniprotkb/ARBA00053535#function" }, { "database": "UniProtKB", "id": "G3N0P5", "url": "https://www.uniprot.org/uniprotkb/G3N0P5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1ML88", "url": "https://www.uniprot.org/uniprotkb/F1ML88" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "PUS7", "url": "https://www.uniprot.org/uniprotkb/F1ML88", "locus": { "chromosome": "4", "start_pos": 46586617, "end_pos": 46640201, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000007743", "url": "https://www.ensembl.org/id/ENSBTAG00000007743" } ] } } ], "crossref": [ { "id": "F1ML88", "url": "https://alphafold.ebi.ac.uk/entry/F1ML88", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000007743", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000007743", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd02576", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02576", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001656", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001656", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020103", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020103", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020119", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020119", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1ML88", "url": "https://www.orthodb.org/?gene=F1ML88", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "G3N0P5", "url": "https://www.orthodb.org/?gene=G3N0P5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13326", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13326", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13326:SF31", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13326:SF31", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01142", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01142", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "42540", "url": "https://www.rhea-db.org/rhea/42540", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "54572", "url": "https://www.rhea-db.org/rhea/54572", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "56644", "url": "https://www.rhea-db.org/rhea/56644", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1ML88", "url": "https://www.uniprot.org/uniprotkb/F1ML88", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1ML88-1", "url": "https://www.uniprot.org/uniprotkb/F1ML88-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0P5", "url": "https://www.uniprot.org/uniprotkb/G3N0P5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3N0P5-1", "url": "https://www.uniprot.org/uniprotkb/G3N0P5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGCSRGWFFRVVLSSALLLRPEQRACLLVARPAPRARSQAPGSLTCFLGYLKMEMTEMTSVSLKRGSVAIEDNDSVAPAEEAKRQKVSGCCPTTGQDGIENSSLPSSEKVPGPPETAEQGEKNSEVPSEEEEEEDGLSEEEEEEEEAESFADMMKHGLTELDVGITKFVSSHQGFSGILKERYSDFVVHEIGRDGRISHLSDLSVPVDEEDPSEDVFTVLTAEEKQRLEELQLFKNKETSVAIEVIEDTKEKRTIIHQAIKSLFPGLETKTEDREGKKYIVAYHAAGKKALANPRKHSWPKSRGSYCHFVLYKENKDTMDAINLLSKYLRVKPNIFSYMGTKDKRAITVQEIAVLKITAQRLAHLNKCLMNFKLGNFSYQKNPLKLGELQGNHFTVVLRNITGTDNQVEQAMNSLKEIGFINYYGMQRFGTTAVPTYQVGRAILQNSWAEVMDLILKPRSGAEKGYLVKCREEWAKTKDPAAALRKLPVKRCVEGQLLRGLSKYGMKNIVSAFGIIPRNNRLMYIHSYQSYVWNNMVSKRIDEYGLKPVPGDLVLKGATATFIEEDDVNNYSIHDVVMPLPGFDVIYPKHKISEAYREMLTADNLDIDNMRHKIRDYSLSGAYRKIIIRPQNVSWEVVAYDDPKIPLFNTDVDNLEGRPPPVFASEGKYRALKMDFSLPPSTYATMAIREVLKMDTSIKNQTQLNTTWLR", "length": 711, "header": "tr|F1ML88-1|F1ML88_BOVIN Isoform 1 of Pseudouridylate synthase 7 homolog OS=Bos taurus OX=9913 GN=PUS7 PE=3 SV=4 CANONICAL=F1ML88-1" }, "isoforms": [ { "isoform_ac": "F1ML88-1", "url": "https://www.uniprot.org/uniprotkb/F1ML88/entry", "sequence": { "sequence": "MLGCSRGWFFRVVLSSALLLRPEQRACLLVARPAPRARSQAPGSLTCFLGYLKMEMTEMTSVSLKRGSVAIEDNDSVAPAEEAKRQKVSGCCPTTGQDGIENSSLPSSEKVPGPPETAEQGEKNSEVPSEEEEEEDGLSEEEEEEEEAESFADMMKHGLTELDVGITKFVSSHQGFSGILKERYSDFVVHEIGRDGRISHLSDLSVPVDEEDPSEDVFTVLTAEEKQRLEELQLFKNKETSVAIEVIEDTKEKRTIIHQAIKSLFPGLETKTEDREGKKYIVAYHAAGKKALANPRKHSWPKSRGSYCHFVLYKENKDTMDAINLLSKYLRVKPNIFSYMGTKDKRAITVQEIAVLKITAQRLAHLNKCLMNFKLGNFSYQKNPLKLGELQGNHFTVVLRNITGTDNQVEQAMNSLKEIGFINYYGMQRFGTTAVPTYQVGRAILQNSWAEVMDLILKPRSGAEKGYLVKCREEWAKTKDPAAALRKLPVKRCVEGQLLRGLSKYGMKNIVSAFGIIPRNNRLMYIHSYQSYVWNNMVSKRIDEYGLKPVPGDLVLKGATATFIEEDDVNNYSIHDVVMPLPGFDVIYPKHKISEAYREMLTADNLDIDNMRHKIRDYSLSGAYRKIIIRPQNVSWEVVAYDDPKIPLFNTDVDNLEGRPPPVFASEGKYRALKMDFSLPPSTYATMAIREVLKMDTSIKNQTQLNTTWLR", "length": 711, "header": "tr|F1ML88-1|F1ML88_BOVIN Isoform 1 of Pseudouridylate synthase 7 homolog OS=Bos taurus OX=9913 GN=PUS7 PE=3 SV=4 CANONICAL=F1ML88-1" }, "locus": { "chromosome": "4", "start_pos": 46640125, "end_pos": 46587580, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000010180.7", "url": "https://www.ensembl.org/id/ENSBTAT00000010180.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000010180.7", "url": "https://www.ensembl.org/id/ENSBTAP00000010180.7" } ] } }, { "isoform_ac": "G3N0P5-1", "url": "https://www.uniprot.org/uniprotkb/G3N0P5/entry", "sequence": { "sequence": "MSSLTCFLGYLKMEMTEMTSVSLKRGSVAIEDNDSVAPAEEAKRQKVSGCCPTTGQDGIENSSLPSSEKVPGPPETAEQGEKNSEVPSEEEEEEDGLSEEEEEEEEAESFADMMKHGLTELDVGITKFVSSHQGFSGILKERYSDFVVHEIGRDGRISHLSDLSVPVDEEDPSEDVFTVLTAEEKQRLEELQLFKNKETSVAIEVIEDTKEKRTIIHQAIKSLFPGLETKTEDREGKKYIVAYHAAGKKALANPRKHSWPKSRGSYCHFVLYKENKDTMDAINLLSKYLRVKPNIFSYMGTKDKRAITVQEIAVLKITAQRLAHLNKCLMNFKLGNFSYQKNPLKLGELQGNHFTVVLRNITGTDNQVEQAMNSLKEIGFINYYGMQRFGTTAVPTYQVGRAILQNSWAEVMDLILKPRSGAEKGYLVKCREEWAKTKDPAAALRKLPVKRCVEGQLLRGLSKYGMKNIVSAFGIIPRNNRLMYIHSYQSYVWNNMVSKRIDEYGLKPVPGDLVLKGATATFIEEDDVNNYSIHDVVMPLPGFDVIYPKHKISEAYREMLTADNLDIDNMRHKIRDYSLSGAYRKIIIRPQNVSWEVVAYDDPKIPLFNTDVDNLEGRPPPVFASEGKYRALKMDFSLPPSTYATMAIREVLKMDTSIKNQTQLNTTWLR", "length": 670, "header": "tr|G3N0P5-1|F1ML88_BOVIN Computationally mapped isoform of Pseudouridylate synthase 7 homolog OS=Bos taurus OX=9913 GN=PUS7 PE=3 SV=3 CANONICAL=F1ML88-1" }, "locus": { "chromosome": "4", "start_pos": 46631217, "end_pos": 46587580, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", 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"MLLPALLFGAAWALANGRWCEQTETVLVEEEVTPRQEDLVPCASLQHYQRRGWRLDLTWSGRAGLCAIYKPPETRPAAWNRTVRACCPGWGGTHCTLVHPEASPEGHCFATWLCNLGAGSVNASAGSLEECCAQPWGHSWRDGRSQTCHSCSNHSRLGSTPSPAILQPLAGAVAQLWSQRQRPSATCATWSGFHYRTFDGRHFHFLGRCTYLLAGAADATWAVHLQPMGHCPQPGHCQLARVMMGPEEVLIRGENVTVNGRLVPEGASQLLPGLSLQWQGDWLVLSGGLGVVVRLDRSSSVSISVDQELQGQTQGLCGVYNGQPEDDFLEPGRGLAALAATFGNSWRLPDSELGCLDAVEAAQGCEDPLRGTETGTEAGQLRAEAQDVCHQLLEGPFRECHTQVPPAEYHEACLFAYCAGAPAGSGRAERLEAVCATLASYAQDCAARRIAVRWRKPGFCERLCPGGQLYSDCASACPPSCSAVGEGSEWSCGEECVSGCECPPGLFWDGALCVPAARCPCYRRRRRYEPGDTVRQLCNPCECRDGRWLCAQAPCAAECAVGGDGHYVTFDGRSFSFRGRAGCRFILVQDFAKRQLLIVLEHGDCDAGSCLHAISVSLGDTLVQLRDSGVVLVDGQDVALPWSAAGGLSVSRASSSFLLLRWPGARILWGVSDPAAYITLDPHHAHQVQGLCGTFTRNQQDDFLTPAGDVETSITAFASKFQVAGGGTCSLEASTPLSPCSTHTERQVFAEVACAILHGPTFQECHGLVDREPFHLRCLAAVCGCTPGRDCLCPVLAAYARRCAQEGALPSWRNQTFCPVLCPGGQEYQECAPACGRNCGEPEDCGELDNCVAGCNCPLGLLWDPEGQCVPPNLCPCQLGAHRYAPGSATMKDCNHCVCQERGLWNCTAHHCAPPRTFCPRELVYVPGACLLTCDSLDADRTCPPGSPGGCVCPPGTVLLEERCVPPELCPCRHGGQWYLPNATIQEDCNLCVCQGQQWHCTGQRCDGRCRASGAPHYVTFDGLALTFPGACEYLLVREASGQFMVSAQNLPCGASGLTCTKALTVRLQGTVVHMLRGRAVMVNGVSVTPPKVYSGPGLSLHTAGLFLLLSTHLGLTLLWDGGTRVLVQLSPQLRGRVAGLCGDFDGDASNDLRSRQGVLEPTAELAAHSWRLGPLCPEPGDLPHPCAVNAHRAGWARARCGVVLQPLFARCHVEVPPQQHYEQCVYDACGCDSGGDCECLCSAIATYADECARHGIHVRWRSQELCPLQCERGQVYEACGPTCPATCHDHRPEPGWPCRAVACVEGCFCPEGTLLHGGVCLEPAACPCEWGGSFFPPGTVLQKDCGNNCTCRESQWLCGDDGGRCVEPGPGCAEGETPCRESGHCVPHGWLCDNQDDCGDGSDEEGCATPVCGEGQVSCSSGRCLPLVLLCDGQDDCGDGMDEQGCPCPQDSLTCADGHCLPPARLCDGHPDCPDGADEESCLGQVDCAPGEVSCVDGTCLGAIQLCDGVWDCLDGADEGPGHCPLPSLPTPPAGTLPGPSAVSWRLHLPPWPVSALALPCGPLDFACGSGECAPRGWRCDGEEDCADGSDESGCDRPCAPHHAPCARGSHCVAAEQLCDGVPHCPDGSDEDPGACERLQAPGGPNRTGLPCPEYSCPDGLCIGFQQVCDGQPDCELAGTAGPSPEEQGCGAWGPWSPWELCSRTCGPGVQGRSRRCSPPSLPVLWHCPGPERQTRACFAAACPEDGAWTSWSRWSPCSEPCGGVTARHRECHPPQNGGRTCATLPGGPPSTRETRPCPQDGCPNVTCSGELVFHACVPCPLTCDDISGQATCPPDRPCGGPGCWCPAGQVLGAQGRCVWPRQCPCLVDGSRYWPGQRVKTDCQLCVCQDGRPRRCQPSPDCAVNCGWSAWSPWAECLGPCGSRSVQWSFRSPNNPRPAGRGHQCRGLHRKARRCQTEPCEGCEQDGRVHRVGERWRAGPCRVCQCLHDGSARCSPYCPLGSCPQDWVLVEGVGESCCHCVPPGENQTVHPMATPVPAPTPSPQIGAPLITYLLPPPGDPCYSPLGLARLPEGSLPASSQQLEHPAWAAILRPAPGAPGWSPVEHADTQGHTPPPYLQLDLLQPRNLTGIIVQGAGSSDWLQVSSDGLHWHSYRDIQPGTQPAPQLFPKNWNGPSTVWMFARMVQARHVRVWPSDGHHQAAPSSDANLDGPLRVELLGCEPAPLCLGVGHRCVSGECAPRGAPCDGVEDCKDGSDEEGCVTPPAGAGRIESTAWSSAPSSAQPGQLPPQPSEGLAEAEADHWHPGRGSPVPPTGKGPASLGSEPHPSPGGSVQTVTPTSQPEAQALRPEMAAVTVLPPHPMVTPEVPAGRSTTPGPFPHVQCSPGQVPCEVLGCVELEQLCDGREDCLDGSDERPCAWAAGTVPFTVPTTTLPGLPASRDLCSPSQLTCGSGECLPAERRCDLQLDCQDGSDENGCVDCGLAPWSGWSSCSRSCGLGLAFQRRELLRPPLPGGSCPPDRLRSQPCFVQACPVAGAWAEWEAWGPCSVSCGGGHRSRRRSCMDPPPKNGGAPCPGPPQERAPCGLQPCAGGTDCGQGRVHVSAELCRKGLVPPCPPSCLDPEANRSCSGLCLEGCRCPPGLLLQDAGCLPLSECPCLVGEELQQPGVPFLLDNCSRCVCEKGALLCEPGGCPVPCGWSAWSSWGPCDRSCGSGLRARFRSPSNPPAASGGAPCEGQRQELQACYSACGAEVPGWTPWAPWSACSQSCLVPGGGPALRSRSRLCPGPGDTSCIGEATEEEPCSPPVCLGLGVWGQWAAWSACSAPCNGGVQTRGRRCSASAPGDPGCQGPHSQTRDCNTQPCTAQCPGDMVFRSAEQCRWEGGPCPGLCLARGPGVECTGVCTAGCACPAGLFLHNSSCLPPSQCPCQLRGQLYAPGAVARLDSCSNCTCISGEMVCASEPCPVACGWSPWTPWSLCSRSCNVGVRRRFRAGTAPPAAFGGAACQGPNMEAEFCSLRPCGGPGGEWGPWSPCSVPCGGGYRNRTRGSSGPSPVDFSTCGLQPCAGPAPGVCPPGKRWLDCAQGPASCAELSAPRGADQPCHPGCYCPSGMLLLNNVCVPTQDCPCTHGGRLHPPGSAVLRPCENCSCVSGLITNCTSWPCKEGQPTWSPWTPWSECSASCGPARRHKHRFCTRPPGGAPSSMAPPLLLSSVPPLCPGPEAEEEPCLLPECDRAGGWGPWGPWSSCSRSCGGGLRSRSRACDQPPPQGLGDYCEGPRAQGAACQALPCPVTNCTAIEGAEYSACGPPCPRSCDDLVHCVWHCQPGCYCPPGQVLSADGTVCVQPGHCSCLDLLTGERHRPGAQLAKPDGCNYCTCSEGQLTCTDLPCPVPGAWCPWSEWTACSQPCQGQTRTRSRACSCPAPQHGGAPCPGEAGEAGAQHQRETCASTPECPVDGAWSPWGPWSPCDVCLGQSHRSRECSWPPTSEGGRPCPGGHRQSRPCQGNSTQCTDCAGGQDLLPCGQPCPRSCEDLSPGVECQPDSMGCQQPRCGCPPGQLSQDGLCVTPSQCRCQYQPGAMGIPENQSRSAGSGLSSWESLEPGEVVTGPCDNCTCVAGILQCQEVPACSGLGLWGSWGPWEDCSVSCGGGEQLRSRRCPRPPCPGPARQSRTCRTQVCREAGCPAGRLYRECQPSEGCPFSCAHVTGQVGCFSAGCEEGCHCPEGTFLHRSACVQECPCVLTALWLQGLGAAGADPGAHLSVLGENGQPLGPGDELGSGQSLRTGCHNCSCAHGKLSCSVEACSKAAGGFSPWGPWGPCSRSCGGLGTRTRSRQCVRPMPAPGGQGCHGPHWDLEYCPSPECPGAAGSTAEPATGLPGGWGLWSPWSPCSGTCTDPAHPAWRSRSRLCLANCTGGAASQERPCNLPSCTELPLCPGPGCEAGNCSWTAWAPWEPCSRSCGVGQQRRLRAYHPPGPGGHWCPDVLTAYQERRFCNLRACPVPGGWSRWSPWSWCDRSCGGGRSLRSRSCSSPPPKNGGAPCVGERHHARLCNPTPCEEGCPAGMEVVSCANRCPRRCSDLQEGIVCQEDQACQQGCRCPEGSLEQDGGCVPLGHCECTDAQGHSWAPGSQHQEACNNCTCRAGQLSCTAQPCPPPAHCAWSRWSAWSPCSRSCGPAGQQSRFRSSTSGSWAPECREEQSQSQPCPQSPCPPLCLQGTRPRSLGDSWLQDGCQQCSCTPEGIICEDAECAGLGAWTPWSPWSDCPVSCGGGNQVRTRVCVASAPPRGGSPCLGPDVQSQRCGLWPCPALPDTCSWGPWGPCSRSCGPGLASRSASCPCLLAEAEPACNSTSPRLDTQACYAGPCLEECVWSSWSSWTRCSCEVLVQQRYRHQRPAPGGAGAGPPCTRLDGHFRPCLTGNCSEDSCAPPFEFQACGSPCTGLCATYLSPWLCQDLPPCQPGCYCPEGLLEQAGGCVPPEQCNCQHVSGEGAGVTLAPGDRLQLGCKECECQRGELQCTSQGCQGLLPLSGWSEWSPCGPCLPLGLLAPASRAALEERWPQDTAGLSPTSAPTLASEQHRHRLCLDPETGRPWAGDPDLCTVPLSQQRLCPDPGACQDLCQWGPWGAWSPCQVPCSGGFRLRWREAGIPPGGGCRGPWAQTESCNMGPCPGESCEAQDTVPTPDCANQCPRSCVDLWDRVECLQGPCRPGCRCPPGQLVQDGHCVPVSSCRCGLPSPNASWALAPAEVVRLDCRNCTCVNGSLACSSHECPTLGPWSAWSNCSAPCGGGTTKRHRSCKEGPGVTPCQAQDMEQQQDCNLQPCPECPPGQVLSACAVSCPRLCSHLQPGTPCMQEPCQLGCDCPRGQLLHNGTCVPPAECPCTQLSLPWGLTLTLEEQHRELPPGTLLTQNCTHCICQGGAFSCSLTDCQECPPGETWQQVAPGELGPCEQTCREPNATETQGNCSGRQAPGCVCQRGHFRSQEGPCVPVDLCECWHHGRPHLPGSEWQEACESCRCVSGESICTQHCPPLTCAQGETAVQEPGGCCPTCRQEAPEEQPVSCRHLTELRNLTKGACYLEQVEVNYCSGHCPSSTNVLPEEPYLQSQCDCCSYRLDPENPVRILNLRCPGGRTELVVLPVIHSCQCSACQGGDFSER", "length": 5146, "header": "tr|F1MLA7-1|F1MLA7_BOVIN Isoform 1 of SCO-spondin OS=Bos taurus OX=9913 GN=SSPO PE=3 SV=3 CANONICAL=F1MLA7-1" }, "isoforms": [ { "isoform_ac": "F1MLA7-1", "url": "https://www.uniprot.org/uniprotkb/F1MLA7/entry", "sequence": { "sequence": "MLLPALLFGAAWALANGRWCEQTETVLVEEEVTPRQEDLVPCASLQHYQRRGWRLDLTWSGRAGLCAIYKPPETRPAAWNRTVRACCPGWGGTHCTLVHPEASPEGHCFATWLCNLGAGSVNASAGSLEECCAQPWGHSWRDGRSQTCHSCSNHSRLGSTPSPAILQPLAGAVAQLWSQRQRPSATCATWSGFHYRTFDGRHFHFLGRCTYLLAGAADATWAVHLQPMGHCPQPGHCQLARVMMGPEEVLIRGENVTVNGRLVPEGASQLLPGLSLQWQGDWLVLSGGLGVVVRLDRSSSVSISVDQELQGQTQGLCGVYNGQPEDDFLEPGRGLAALAATFGNSWRLPDSELGCLDAVEAAQGCEDPLRGTETGTEAGQLRAEAQDVCHQLLEGPFRECHTQVPPAEYHEACLFAYCAGAPAGSGRAERLEAVCATLASYAQDCAARRIAVRWRKPGFCERLCPGGQLYSDCASACPPSCSAVGEGSEWSCGEECVSGCECPPGLFWDGALCVPAARCPCYRRRRRYEPGDTVRQLCNPCECRDGRWLCAQAPCAAECAVGGDGHYVTFDGRSFSFRGRAGCRFILVQDFAKRQLLIVLEHGDCDAGSCLHAISVSLGDTLVQLRDSGVVLVDGQDVALPWSAAGGLSVSRASSSFLLLRWPGARILWGVSDPAAYITLDPHHAHQVQGLCGTFTRNQQDDFLTPAGDVETSITAFASKFQVAGGGTCSLEASTPLSPCSTHTERQVFAEVACAILHGPTFQECHGLVDREPFHLRCLAAVCGCTPGRDCLCPVLAAYARRCAQEGALPSWRNQTFCPVLCPGGQEYQECAPACGRNCGEPEDCGELDNCVAGCNCPLGLLWDPEGQCVPPNLCPCQLGAHRYAPGSATMKDCNHCVCQERGLWNCTAHHCAPPRTFCPRELVYVPGACLLTCDSLDADRTCPPGSPGGCVCPPGTVLLEERCVPPELCPCRHGGQWYLPNATIQEDCNLCVCQGQQWHCTGQRCDGRCRASGAPHYVTFDGLALTFPGACEYLLVREASGQFMVSAQNLPCGASGLTCTKALTVRLQGTVVHMLRGRAVMVNGVSVTPPKVYSGPGLSLHTAGLFLLLSTHLGLTLLWDGGTRVLVQLSPQLRGRVAGLCGDFDGDASNDLRSRQGVLEPTAELAAHSWRLGPLCPEPGDLPHPCAVNAHRAGWARARCGVVLQPLFARCHVEVPPQQHYEQCVYDACGCDSGGDCECLCSAIATYADECARHGIHVRWRSQELCPLQCERGQVYEACGPTCPATCHDHRPEPGWPCRAVACVEGCFCPEGTLLHGGVCLEPAACPCEWGGSFFPPGTVLQKDCGNNCTCRESQWLCGDDGGRCVEPGPGCAEGETPCRESGHCVPHGWLCDNQDDCGDGSDEEGCATPVCGEGQVSCSSGRCLPLVLLCDGQDDCGDGMDEQGCPCPQDSLTCADGHCLPPARLCDGHPDCPDGADEESCLGQVDCAPGEVSCVDGTCLGAIQLCDGVWDCLDGADEGPGHCPLPSLPTPPAGTLPGPSAVSWRLHLPPWPVSALALPCGPLDFACGSGECAPRGWRCDGEEDCADGSDESGCDRPCAPHHAPCARGSHCVAAEQLCDGVPHCPDGSDEDPGACERLQAPGGPNRTGLPCPEYSCPDGLCIGFQQVCDGQPDCELAGTAGPSPEEQGCGAWGPWSPWELCSRTCGPGVQGRSRRCSPPSLPVLWHCPGPERQTRACFAAACPEDGAWTSWSRWSPCSEPCGGVTARHRECHPPQNGGRTCATLPGGPPSTRETRPCPQDGCPNVTCSGELVFHACVPCPLTCDDISGQATCPPDRPCGGPGCWCPAGQVLGAQGRCVWPRQCPCLVDGSRYWPGQRVKTDCQLCVCQDGRPRRCQPSPDCAVNCGWSAWSPWAECLGPCGSRSVQWSFRSPNNPRPAGRGHQCRGLHRKARRCQTEPCEGCEQDGRVHRVGERWRAGPCRVCQCLHDGSARCSPYCPLGSCPQDWVLVEGVGESCCHCVPPGENQTVHPMATPVPAPTPSPQIGAPLITYLLPPPGDPCYSPLGLARLPEGSLPASSQQLEHPAWAAILRPAPGAPGWSPVEHADTQGHTPPPYLQLDLLQPRNLTGIIVQGAGSSDWLQVSSDGLHWHSYRDIQPGTQPAPQLFPKNWNGPSTVWMFARMVQARHVRVWPSDGHHQAAPSSDANLDGPLRVELLGCEPAPLCLGVGHRCVSGECAPRGAPCDGVEDCKDGSDEEGCVTPPAGAGRIESTAWSSAPSSAQPGQLPPQPSEGLAEAEADHWHPGRGSPVPPTGKGPASLGSEPHPSPGGSVQTVTPTSQPEAQALRPEMAAVTVLPPHPMVTPEVPAGRSTTPGPFPHVQCSPGQVPCEVLGCVELEQLCDGREDCLDGSDERPCAWAAGTVPFTVPTTTLPGLPASRDLCSPSQLTCGSGECLPAERRCDLQLDCQDGSDENGCVDCGLAPWSGWSSCSRSCGLGLAFQRRELLRPPLPGGSCPPDRLRSQPCFVQACPVAGAWAEWEAWGPCSVSCGGGHRSRRRSCMDPPPKNGGAPCPGPPQERAPCGLQPCAGGTDCGQGRVHVSAELCRKGLVPPCPPSCLDPEANRSCSGLCLEGCRCPPGLLLQDAGCLPLSECPCLVGEELQQPGVPFLLDNCSRCVCEKGALLCEPGGCPVPCGWSAWSSWGPCDRSCGSGLRARFRSPSNPPAASGGAPCEGQRQELQACYSACGAEVPGWTPWAPWSACSQSCLVPGGGPALRSRSRLCPGPGDTSCIGEATEEEPCSPPVCLGLGVWGQWAAWSACSAPCNGGVQTRGRRCSASAPGDPGCQGPHSQTRDCNTQPCTAQCPGDMVFRSAEQCRWEGGPCPGLCLARGPGVECTGVCTAGCACPAGLFLHNSSCLPPSQCPCQLRGQLYAPGAVARLDSCSNCTCISGEMVCASEPCPVACGWSPWTPWSLCSRSCNVGVRRRFRAGTAPPAAFGGAACQGPNMEAEFCSLRPCGGPGGEWGPWSPCSVPCGGGYRNRTRGSSGPSPVDFSTCGLQPCAGPAPGVCPPGKRWLDCAQGPASCAELSAPRGADQPCHPGCYCPSGMLLLNNVCVPTQDCPCTHGGRLHPPGSAVLRPCENCSCVSGLITNCTSWPCKEGQPTWSPWTPWSECSASCGPARRHKHRFCTRPPGGAPSSMAPPLLLSSVPPLCPGPEAEEEPCLLPECDRAGGWGPWGPWSSCSRSCGGGLRSRSRACDQPPPQGLGDYCEGPRAQGAACQALPCPVTNCTAIEGAEYSACGPPCPRSCDDLVHCVWHCQPGCYCPPGQVLSADGTVCVQPGHCSCLDLLTGERHRPGAQLAKPDGCNYCTCSEGQLTCTDLPCPVPGAWCPWSEWTACSQPCQGQTRTRSRACSCPAPQHGGAPCPGEAGEAGAQHQRETCASTPECPVDGAWSPWGPWSPCDVCLGQSHRSRECSWPPTSEGGRPCPGGHRQSRPCQGNSTQCTDCAGGQDLLPCGQPCPRSCEDLSPGVECQPDSMGCQQPRCGCPPGQLSQDGLCVTPSQCRCQYQPGAMGIPENQSRSAGSGLSSWESLEPGEVVTGPCDNCTCVAGILQCQEVPACSGLGLWGSWGPWEDCSVSCGGGEQLRSRRCPRPPCPGPARQSRTCRTQVCREAGCPAGRLYRECQPSEGCPFSCAHVTGQVGCFSAGCEEGCHCPEGTFLHRSACVQECPCVLTALWLQGLGAAGADPGAHLSVLGENGQPLGPGDELGSGQSLRTGCHNCSCAHGKLSCSVEACSKAAGGFSPWGPWGPCSRSCGGLGTRTRSRQCVRPMPAPGGQGCHGPHWDLEYCPSPECPGAAGSTAEPATGLPGGWGLWSPWSPCSGTCTDPAHPAWRSRSRLCLANCTGGAASQERPCNLPSCTELPLCPGPGCEAGNCSWTAWAPWEPCSRSCGVGQQRRLRAYHPPGPGGHWCPDVLTAYQERRFCNLRACPVPGGWSRWSPWSWCDRSCGGGRSLRSRSCSSPPPKNGGAPCVGERHHARLCNPTPCEEGCPAGMEVVSCANRCPRRCSDLQEGIVCQEDQACQQGCRCPEGSLEQDGGCVPLGHCECTDAQGHSWAPGSQHQEACNNCTCRAGQLSCTAQPCPPPAHCAWSRWSAWSPCSRSCGPAGQQSRFRSSTSGSWAPECREEQSQSQPCPQSPCPPLCLQGTRPRSLGDSWLQDGCQQCSCTPEGIICEDAECAGLGAWTPWSPWSDCPVSCGGGNQVRTRVCVASAPPRGGSPCLGPDVQSQRCGLWPCPALPDTCSWGPWGPCSRSCGPGLASRSASCPCLLAEAEPACNSTSPRLDTQACYAGPCLEECVWSSWSSWTRCSCEVLVQQRYRHQRPAPGGAGAGPPCTRLDGHFRPCLTGNCSEDSCAPPFEFQACGSPCTGLCATYLSPWLCQDLPPCQPGCYCPEGLLEQAGGCVPPEQCNCQHVSGEGAGVTLAPGDRLQLGCKECECQRGELQCTSQGCQGLLPLSGWSEWSPCGPCLPLGLLAPASRAALEERWPQDTAGLSPTSAPTLASEQHRHRLCLDPETGRPWAGDPDLCTVPLSQQRLCPDPGACQDLCQWGPWGAWSPCQVPCSGGFRLRWREAGIPPGGGCRGPWAQTESCNMGPCPGESCEAQDTVPTPDCANQCPRSCVDLWDRVECLQGPCRPGCRCPPGQLVQDGHCVPVSSCRCGLPSPNASWALAPAEVVRLDCRNCTCVNGSLACSSHECPTLGPWSAWSNCSAPCGGGTTKRHRSCKEGPGVTPCQAQDMEQQQDCNLQPCPECPPGQVLSACAVSCPRLCSHLQPGTPCMQEPCQLGCDCPRGQLLHNGTCVPPAECPCTQLSLPWGLTLTLEEQHRELPPGTLLTQNCTHCICQGGAFSCSLTDCQECPPGETWQQVAPGELGPCEQTCREPNATETQGNCSGRQAPGCVCQRGHFRSQEGPCVPVDLCECWHHGRPHLPGSEWQEACESCRCVSGESICTQHCPPLTCAQGETAVQEPGGCCPTCRQEAPEEQPVSCRHLTELRNLTKGACYLEQVEVNYCSGHCPSSTNVLPEEPYLQSQCDCCSYRLDPENPVRILNLRCPGGRTELVVLPVIHSCQCSACQGGDFSER", "length": 5146, "header": "tr|F1MLA7-1|F1MLA7_BOVIN Isoform 1 of SCO-spondin OS=Bos taurus OX=9913 GN=SSPO PE=3 SV=3 CANONICAL=F1MLA7-1" }, "locus": { "chromosome": "4", "start_pos": 112677506, "end_pos": 112626094, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000043975.4", "url": "https://www.ensembl.org/id/ENSBTAT00000043975.4" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000041504.4", "url": "https://www.ensembl.org/id/ENSBTAP00000041504.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1089, "start_aa": "Thr", "end_pos": 1089, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1089", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1283, "start_aa": "Thr", "end_pos": 1283, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1283", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 1532, "start_aa": "Thr", "end_pos": 1532, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1532", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "icn3d_view": {}, "start_pos": 2041, "start_aa": "Thr", "end_pos": 2041, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr2041", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "000000000000000010000.00000000001000.0.01000" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-BTA-5173214", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-5173214", "resource": "Reactome", "description": "O-glycosylation of TSR domain-containing proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "Q700K0-1", "protein_name": "SCO-spondin", "gene_name": "Sspo", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLPALLFGMLWAPANGHWCEQIETVHVEEEVTPRREDLVPCTSLYHYSRLGWKLDLSWGGHVGLTRPPALGLCAIYKPPETRPATWNRTVRACCPGWGGIHCTEALAEASPKGHCFVTWHCQPLAGSANSSAGSLEECCAQPWGHSWWNSSSQMCLSCSGQHRPGNASSEGLLQPLAGAVGQLWSQRQRPSATCATWSGFHYQTFDGQHYHFLGQCTYLLAGAMDSTWAVHLRPSVHCPQPRQCWLVQVIMGPEEVLIQDGEVSVKGQPVPVGESQLLHGMSLQWQGDWLVLSGGLGVVVRLDRSSSIIISVDHEFWGRTQGLCGLYNGRPEDDFVEPGGGLAMLAATFGNSWRLPGYEPGCLDTVEVARGCEGLLEGTLTGLEAGKLQAQAQDLCHQLLEDPFSQCHGQVPPDEYHETCLFAYCVGATAGSGPEEQVKAVCATFANYAQACARQHIYVHWRKPGFCERLCPGGQLYSDCISSCPPSCSAVAQGEEGSCGKECVSGCECPTGLFWDGALCVPAAHCPCYYRRQRYAPGDTVKQQCNPCVCQDGRWHCAQAPCPAECAVGGDGHYCTFDGRSFSFRGNPGCQYSLVQDSVKGQLLVVLEHGACETGSCLHALSAFLGKTHIQLRYSGAVLVDGQDVDLPWIGAEGFNVSHASSTFLLLRWPGAWVLWGVADPAVYITLDPRHAYQVQGLCGTFTWKQQDDFLTPAGDIETSVTAFASKFQVSGDGRCPLVDNTPLSSCSTYSQRLAFAEAACAALHGHAFQECHGLVEREPFRLRCLESMCSCAPGRDCLCSVLSAYAHHCAQEGVLLQWRNETLCSVPCPGGQVYQECAPACGHYCGEPEDCKELGSCVAGCNCPPGLLWDLEGQCVPPSMCPCQLGGHRYAFNTTTTLKDCSHCICQERGLWNCIAHHCPRQWALCPQELIYAPGACLLTCDSLGANHSCLAGSTDGCVCPSGTVLLDKHCVSPDLCPCRHNGQWYPPNATIQEDCNICVCQNQRWHCTGQRCSGWCQASGAPHYVTFDGLVFTFPGACEYLLVREAGGRFSVSIQNLPCGASGLTCTKALAVRLDSTVVHMLRGQAVTVNGVSIKLPKVYTGPGLSLHHAGLFLLLTTRLGLTLLWDGGTRVLVQLSPHFHGRVTGLCGNFDGDVSNDLRSRQGVLEPTAELTAHSWRLNPLCPEPGDLPHPCSVNAHRVNWARAHCEVILQPIFAPCHTEVPPQQYYEWCVYDACGCDTGGDCECLCSAIATYADECARHRHHVRWRSQELCPLQCEGGQVYEPCGSTCPPTCHDHHPELRWHCQAITCVEGCFCPEGTLLHGGTCVELTDCPCEWQGSFFPPGAVLQKDCGNCTCQESQWHCNPSGAPCEEMEPGCAEGEALCRESGHCVPLEWLCDNQDDCGDGSDEEGCDTSVCGEGQMSCQSGRCLPLSLICDGQDDCGDGTDEQGCLCPQGFLACADGRCLPPALLCDGHPDCLDAADEESCLGWVSCTSGEVSCVDGPCIRTIQLCDGVWDCPDGADEGPVHCSSPSLPTPPAGIGQNPSTSSPDTSPSPVGSASPASPCSLSEFQCNSGECTPRGWRCDREEDCTDGSDELDCGGPCKLYQMPCAHGPHCLSPGQLCDGVAQCPDGSDEDPDVCEERSASGGPNGTAVPCPEFSCPNGTCIDFLLVCDGSPDCELADETEPSLDEQGCGTWGSWGPWEPCSQTCGPGIQSRNRNCSISSLHVLQNCPGLQHQSQSCFTEACPVDGEWSSWSLWSPCSEPCGGTMTRHRQCRPPQNGGQDCALLPGSTHSTHQTSPCPQEGCLNVTCFGELVFRPCAPCPLTCDDISGEAVCSPDRPCSSPGCWCPEGKVLGTEGRCVRPRQCPCLVDGIRYWPGQRIKMDCQLCFCQDGQPHRCRPNPECAVDCGWSSWSPWAECLGPCSSQSLQWSFRSPNNPRLSGHGRQCRGIHRKARRCQTEPCEGCEQWGLTYHVGERWRGGPCTVCECLHRSITRCSPYCPIGSCPQSWVLVEGMGESCCHCALPGKNQTMIPVTTPAPVPTPSPQIGASLVTYVLPPMSDACYSPLGLAGLPTWAPSQPLEHSTRAAPVEAPTAGPGPREDAYAEWHTQPLYLQLDLLWPRNLTGIMVQRAGSSAAYISNLSLQFSSDGLQWHSVLNSLSSTLPPPKPSPESSNHMVPEVWTFDQMVQARYIRVWPHGSHLRDNNQQDIFLWVELLGCKPVPPLAPLCPGTRHRCANGDCALKGGPCDGAVDCEDGSDEEGCGPLRASTASRVHSTARTPALSPTQPGKFPFHPREGLADMEHQQPKQESPMPSAGVSPSASEGLLPVSGQSMQTLTTTSTFPPGLKSLHPGMAAVTVHSPHSVMPGTPVGQSVSPRPFPLMRCGPGQVPCDVLGCVEQEQLCDGREDCLDGSDEQHCASPEPFTVPTTALPGLPASRALCSPSQLSCGSGECLPLEHRCDLQVNCQDGSDEDDCVDCVLAPWSGWSDCSRSCGLGLIFQHRELLRPPLPGGSCLLDQLRSQPCFVQACPVAGAWAKWGPWEPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGPSHEKVLCNLQLCPGDTDCEPGRVHVNAELCQKGLLPPCPPSCLDPEANRSCSGHCVEGCRCPPGLFLQDSHCLPLSECPCLVGQKLMQPGLAFLLDNCSQCICESGILLCKPAACSQSCGWSAWSPWTACDHSCGSGVRARFRSPTNPPAAFGGSPCEGDRQELQACYTDCGTDIPGWTPWTSWSSCSQSCLVPGGDPGRRQRSRLCPSSRDTFCPGEATQEEPCSPSLCPVPSAWGLWASWSACSASCNGGIQTRGRSCSGSAPGNPVCLGPHTQTRDCNVHPCTAQCPGNMVFRSAEKCLEEGGPCPQLCLAQDPGVECTGSCAPGCSCPPGLFLHNASCLPRSQCPCQLHGQLYAPGAVARLDCNNCTCSSGEMVCTSERCPVACGWSPWTPWSPCSQSCNVGIRRRFRAGTAPPAAFGGAECRGPNLDAEFCTLRPCQGPGAAWSSWTPCSVPCGGGYRNRTQGSGRHSPVEFSTCSLQPCAGPVPGVCPKDQQWLDCAQGPASCAHLSTPREANQTCHPGCYCLSGMLLLNNVCVPAQDCPCAHRGRLHSPGSAVILPCENCSCVSGLITNCSSWPCEEGQPAWSSWTPWSVCSASCSPARRHRRRFCVRPSTTAPFSLDLPTTVAAPTMLCPGPEAEEEPCLLPGCNQAGVWGPWSPWSGCSRSCGGGLRSRTRACDKPPPQGLGDFCEGPQAQGEACQAQPCPVANCSTIEGAEYSPCGPPCPRSCDDLVHCMWHCQPGCYCPPGKVLSADGAICVQPHHCSCLDLLTGKRHHPGSQLMRPDGCNHCTCMEGRLNCTDLPCQVSGDWCPWSEWTACSQPCRGQTRTRSRACVCPAPQHGGAPCPEEAGETGVQHQMEACPNPTACPVDGAWSPWGSWSPCDACLGQSYRSRMCSHPPPSDGGTPCLGGHQQSRPCRNSSTPCTDCGGGQDLLPCGQPCPHSCQDLSLGSTCQPGSSGCQSGCGCPPGQLSQDGLCVFPADCHCHFQPKAMGIPENQSRSVGSALSSWESLEPGEVVTGPCDNCTCVAGVLQCHEVPSCPGPGIWSSWGPWEKCSVPCGGGEQLRSRQCARPPCPGLAQQSRTCHIHVCRETGCPAGRLYRECQPSEGCPFSCAHVTGQVACFSESCEEGCHCPEGTFQHHSACVQECPCVLTVSLLQELGVASTALRSYPVLLGDEGQPLGPGDELDPGQMLQTVCGNCSCVHGKLSCSMEECSRVRGYFGPWGMWSLCSHSCGGLGTRTRTRQCVLPTLAPAGLSCRGPLQDLEYCFSPECPGTAGSTVEPVTGLAGGWGPWSPWSPCSHSCTDLTHPAWRSRTRLCLANCTVGDSSQERPCNLPSCTTLPLCPGPGCGSENCFWTSWAPWEPCSRSCGVGQQRRLRAYHPPGPGGHWCPDILTAYQERRFCNLRACPVPGGWSHWSPWSWCDRSCGGGRSLRSRSCSSPPPKNGGASCVGERHHVRSCNPMPCEKDCPAGMEMVSCANRCPYSCSDLQEAVMCQEDQACQLGCRCSEGFLEQDGGCVPVGHCECTDAQGRSWAPGSQHQDACNNCSCQAGQLSCTAQPCPPPAHCAWSHWSAWSACSHSCGPHGQQSRFRSSTSGSWALECQKEQSQSQPCPEDPCPPLCLHEAHLHVLGDNWLHGECQQCSCTPEGVICKDTDCAVPGGWTLWSSWSYCSVSCGGGSQVRTRSCMVSAPQHGSPSCQGPDTQTQHCGQQLCLQLLEICSWGPWGPCSRSCGTGLASRSGSCPCLLTKEDSECNDTFSGLDTQACYPGPCQEDCMWSDWSSWTRCSCKILVQQRYRHQVPAPGQAGEGTLCTGLDGHFRPCAIGNCSEDSCLPPFEFQSCGSPCAGLCATHLSHQLCQDLPPCQPGCYCPMGLLEQDGGCILPEQCNCWHTSGEGARVTLAPGHRLQLGCKECVCQSGELQCSSQGCEGLLPLTGWSEWSPCGPCLPQSALAPDSRTALEVHWPLNTSVTLLASEQYRHRLCLDPETGRPWAGDPALCTVPLSQQRLCSDPGACHDTCQWGPWGPWSPCQVPCSGGFKLRWREASDNSVGECRGPWAQTESCNMGSCPGESCETRDTVFTLDCANQCPRSCADLWEGVQCLQGPCSPGCRCPPGQLVQDGHCVPISSCRCGLPSANASWELAPTQVVQLDCHNCTCINGTLMCPYPECPVLGPWSPWSECSAVCGGGTMVRYRSCEEHPDSAPCQALDMEQRVECNLQTCPECPPGQVLSTCATLCPSFCSHLWPGTICVREPCQLGCGCPGGQLLHSGTCIPPEACPCTRLSLPWGLTLPLEEQAQELPSGTVLTWNCTHCTCQGGVFTCSHTDCQECPPGEILQLGELRPCEKTCLEMNKTQAWSNCTEAQVPGCVCQLGHFRSHTGLCVPEDHCECWHHGSPHLPGSEWQEACESCRCLHGKSVCTQHCPELSCAQGEVVVQEPGSCCPICQQDTLEEEPVSCRHLTELRNLTKGPCHLDQVEVSYCSGHCRSSTNVMTEEPYLQSQCDCCSYRLDPDSPVRILNLLCPDGRTEPVLLPVIHNCHCSACQGGEFSKH", "length": 5141 }, "evidence": [ { "id": "F1MLA7", "url": "https://omabrowser.org/oma/group/F1MLA7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CG65-1", "protein_name": "SCO-spondin", "gene_name": "Sspo", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLPLALLFGMLWTQANGHWCEQIETVHVEEEVTPRQEDLVPCTSLYHYSRLGWQLDLSWSGRVGLTRPPALGLCAIYKPPETRPATWNRTVRACCPGWGGAHCTDALAETSPKGHCFVTWHCQPLAGSANSSAGSLEDPADELGVWPLTLNDPILFPGMSLQWQGDWLVLSGGLGVVVRLDRSSSISISVDHEFWGRTQGLCGLYNGRPEDDFVEPGGGLATLAATFGNSWKLPGSEPGCLDAVEVAWGCESLLGGTLTDLEAVKLQAQAQDMCHQLLEGPFWQCHGQVQPDEYHETCLFAYCVGATAGNGPEGQLEAVCATFANYAQACARQHIYVHWRKPGFCERVCPGGQLYSDCVSSCPPSCSAVAQGEEGSCGKECVSGCECPTGLFWDGALCVPAAHCPCYHRRQRYAPGDTVKQQCNPCVCQDGRWHCAQALCPAECAVGGDGHYFTFDGRSFFFRGTPGCHYSLVQDSVKGQLLVVLEHGACDTGSCLHALSVFLGNTHIQLRYSGAVLVDGEDVDLPWIGVEGFNISWASSTFLLLHWPGAWVLWGVAEPAAYITLDPRHAYQVQGLCGTFTWKQQDDFLTPAGDIETSVTAFASKFQVSGDGRCPLVDKSPLFCSSYSQHLTFTEAACAILHGHAFQECHGLVDREPFRLRCLEAVCGCAPGRDCLCPVLSAYTRHCAQEGVLLQWRNETLCPVSCPGGQVYQECAPVCGHHCGEPEDCKELGICVAGCNCPPGLLWDLEGQCVPPSMCHCQFGGHRYTINTTTVRDCSHCICQERGLWNCTAHHCPRQWALCPRELIYVPGACLLTCDSPRANHSCWAGSTDGCVCPPGTVLLDKHCVSPDLCPCRHNGQWYPPNATIQEDCNICVCQGQRWHCTGQRCSGWCQASGAPHYVTFDGLVFTFPGACEYLLVREAGGRFSVSVQNLPCGASGLTCTKALVVRLDSTVVHMLRGQAVTVNGVSIRLPKVYTGPGLSLHHAGLFLLLTTRLGLTLLWDGGTRVLVQLSPHFHGRVAGLCGNFDSDASNDLRSRQGVLEPTAELTAHSWRLNPLCPEPGDLPHPVNAHRANWARARCEVILQPIFAPCHTEVPPQQYYEWCVYDACGCDTGGDCECLCSAIATYADECARHRHHVRWRSQELCPLQCEGGQVYEPCGSTCPPTCHDHHSELRWHCQVITCVEGCFCPEGTLLHGGACMKLAACPCEWQGSFFPPGTVLQKDCGNCTCQGSQWHCDRGGAPCEDMEPGCAEGETLCRENGHCVPLEWLCDNQDDCGDGSDEEGCATSVCGEGQMSCQSGHCLPLSLICDGQDDCGDGTDEQGCLCPHGSLACADGRCLPPALLCNGHPDCLDAADEESCLGPVSCISGEVSCVDGTCVRTIQLCDGVWDCPDGADEGPSHCSLPSLPTPPGGIGQNPSTSSLDTAPSPVGSTSPASPCSLLEFQCNSGECTPRGWRCDQEEDCTDGSDELDCGGPCMLYQVPCAHSPHCVSPGQLCDGVTQCPDGSDEDPDVCEEQSASGGANRTGAPCPEFSCPDGTCIDFLLVCDGNPDCELADETEPSLDEQGCGAWGSWGPWAPCSQTCGSGTRSRNRNCSTSSLQVLQNCPGLQHQSQACFTEACPVDGEWSSWSPWSPCSEPCGGTTTRHRQCRPPQNGGQDCALLPGSTHSTRQTSPCPQEGCLNATCFGELVFRTCAPCPLTCDDISGQAACPPDRPCSSPGCWCPDGKVLNTEGQCVRPRQCPCLVDGAHYWPGQRIKMDCQLCFLDCGWSSWSPWAECLGPCSSQSLQWSFRSPNNPRLSGHGRQCRGIHRKARRCQTEACEGCEQWGLMYNVGERWRGGPCMVCECLHSSITHCSPYCPIGSCPQGWVLVEGMGESCCHCALPEKNQTVIHMTTPAPAPASAPSPQIGAHLVTYVLPPTADACYSPLGLAGLPMWAPSQHWEHITRADPVEAPMAGPGPREGASAEWHTQPLYLQLDLRRPRNLTGIIVQRAGSSAAYVSTLSLQFSSDNLQWHNYVNSLSSTLSPPKPSPESSNHMAPEVWTFDQMVQARYIRVWPHSGHLRDNNQHDIFLWVELLGLSPLAPLCPGSRHRCASGECAPKGGPCDGAVDCDDGSDEEGCGSLHASTTSRTPALSPTQPGKFPREVSEDLRQGAEAMTSHSPPSSGETAGLIPASEGTLPVSGQPMQTLSATSTFPPGAKSLHPGMAAVTVHPPHSVTPGAPVGQTVSPRPFPPMPCGPGQVPCDVLGCVEQEQLCDGREDCLDGSDEQHCASAEPFTVPTTALPGLPASKALCSPSQLRCGSGECLPFEHRCDLQVNCQDGSDEDNCVDCVLAPWSGWSDCSRSCGLGLIFQHRELLRLPLPGGSCLLDQFRSQSCFVQACPVAGAWAEWGPWTACSVSCGGGHQSRQRSCVDPPPKNGGAPCPGPSHEKAPCNLQLCPGDTDCEPGLVHVNAELCQKGLVPPCPPSCLDPEANRSCSGHCMEGCRCPPGLLLQDSHCLPLSECPCLVGQKLIQPRLAFLLDNCSQCICEKGTLLCKPGACSQSCGWSAWSPWTACDRSCGSGVRARFRSPTNPPVAFGGSPCEGDRQELQACYTDCGTEIPGWTPWTSWSSCSQSCLVPGGDPGWRQRSRLCPSSRDTFCPGEATQEEPCSPPVCPVPSAWGLWASWSTCSASCNGGIQTRGRSCSGSAPGNPVCLGPHTQTRDCNMHPCTAQCPGNMVFRSAEQCLEEGGPCPQLCLAQDPGVECTGSCAPSCNCPPGLFLHNASCLPRSQCPCQLHGQLYAPGAVAHLDCNNCTCISGEMVCTSKRCPVACGWSPWTPWSPCSQSCNVGIRRRFRAGTEPPAAFGGAECQGPNLDAEFCSLRPCRGPGAAWSSWTPCSVPCGGGYRNRTQGSGPHSPIEFSTCSLQPCAGPVPGVCPEDQQWLDCAQGPASCAHLSIPGEANQTCHPGCYCLSGMLLLNNVCVPVQDCPCAHRGRLYSPGSAVHLPCENCSCISGLITNCSSWPCEEGQPAWSSWTPWSVCSASCNPARRHRHRFCARPPHRAPFSLVLLTTVAAPTTLCPGPEAEEEPCLLPGCNQAGGWSPWSPWSGCSRSCGGGLRSRTRACDQPSPQGLGDFCEGPQAQGEACQAQPCPVTNCSAMEGAEYSPCGPPCPRSCDDLVHCVWRCQPGCYCPLGKVLSADGAICVKPSYCSCLDLLTGKRHHAGTQLMRPDGCNHCTCMEGRLNCTDLPCQVSGDWCPWSKWTACSQPCRGQTRTRSRACVCPAPQHGGSPCPEESGGTGVQHQMEACPNATACPVDGAWSPWGPWSSCDACLGQSYRSRVCSHPPISDGGKPCLGGYQQSRPCRNSSTLCTDCGGGQDLLPCGQPCPHSCQDLSLGSTCQPGSAGCQSGCGCPPGQLSQDGLCVFPVDCHCHFQPRAMGIPENRSRSVGSTLSSWESLEPGEVVTGPCDNCTCVAGILQCHEVPSCPGPGIWSSWGPWEKCSVSCGGGEQLRSRQCARPPCPGLAQQSRICHIHVCRETGCPAGRLYRECQPSDGCPFSCAHVTGQVACFSERCKEGCHCPEGTFQHHVACVQECPCVLTVLLLQELGLASAALGSYPTLLGDEGKPLGPGVELLPGQMLQTDCGNCSCVHGKLSCSMVECSRVHGSFGPWGMWSLCSRSCGGLGTRTRTRQCVLPTLAPGGLSCRGPLQDLEYCFSPECPGTAGSTVEPVTGLAGGWGPWSPWSPCSHSCTDPAHPAWRSRTRLCLANCTVGDSSQERPCNLPSCAALLPCPGPGCGSGNCFWTSWAPWEPCSRSCGVGQQRRLRAYHPPGPGGHWCPDILTAYQERRFCNLRACPVPGGWSHWSPWSWCDRSCGGGRSLRSRSCSSPPPKNGGTSCVGERHHVRPCNPMPCEEGCPAGMEMVSCANHCPYSCSDLQEGGMCQEDQACQLGCRCSEGFLEQDGGCVPVGHCECTDAQGRSWAPGSQHQDACNNCSCQAGQLSCTAQLCSPPAHCAWSHWSAWSSCSHSCGPQGQQSRFRSSTSGSWALECQKEQSQSQPCPEVPCPPLCLHEAHLHELGDNWLHGECQQCSCTPEGAICKDTDCAVPRGWTLWSSWSYCSVSCGGGSQVRTRSCTVSAPPHGSLSCEGPDTQTRHCGQQLCLQKLERCSWGPWGPCSRSCGTGLASRSGSCPCLLTKEDSKCNDTFLGLDTQACYSGPCQDDCTWGDWSSWTRCSCKVLVQQRYRHQVPAPGQAGEGTPCTRLDGHFRPCTIGNCSEDSCPPPFEFQSCGSPCAGLCATHLNHRLCQDLPPCQPGCYCPKGLLEQAGSCILPEQCNCWHISGEGARVTLAPGDRLQLGCKECVCRRGELQCSSQGCEGLLPLTGWSEWSPCGPCLPQSALAPASRTALEGHWPLNTSDLPPPSVTLLASEQYRHRLCLDPETRRPWAGDPALCTVPLSQQRLCPDPGACNDTCQWGPWGPWSPCQMPCSGGFKLRWRVARDTSAGECPGPWAQTESCNMGSCPGESCETRDTVFTLDCANQCPRSCADLWDGVQCLQGPCSPGCRCPPGQLVQDGHCVPISSCRCGLPSANASWELAPTQVVQLDCHNCTCINGTLMCPHLECPVLGPWSAWSECSAVCGKGTMVRHRSCEEHPDREPCQALDLQQWQECNLQACPECPPGQVLSTCATMCPSLCSHLWPGTICVREPCQLGCGCPGGQLLYNGTCIPPEACPCTQFSLPWGLTLPLEEQARELPSGTVLTRNCTHCTCQGGAFICSLTDCQECAPGEIWQHGKLGPCEKTCPEMNMTQAWSNCTEAQAPGCVCQLGYFRSQTGLCVPEDHCECWHHGSPHLPGSEWQEACESCRCLHGKSVCIRHCPELSCAQGEVIMQEPGSCCPICQQDTLKEEPVSCRYLTELRNLTKGPCHLDQIEVSYCSGHCRSSTNVMTEEPYLQSQCDCCSYRLDPDSPVRILNLLCPDGHTEPVVLPVIHSCQCSACQGGDFSKH", "length": 4998 }, "evidence": [ { "id": "F1MLA7", "url": "https://omabrowser.org/oma/group/F1MLA7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "F1MLA7", "url": "https://www.uniprot.org/uniprotkb/F1MLA7" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "F1MLA7", "url": "https://www.uniprot.org/uniprotkb/F1MLA7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1MLA7", "url": "https://www.uniprot.org/uniprotkb/F1MLA7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "peptidase inhibitor activity", "id": "GO:0030414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030414", "evidence": [ { "database": "UniProtKB", "id": "F1MLA7", "url": "https://www.uniprot.org/uniprotkb/F1MLA7" } ], "pmid": "" }, { "name": "extracellular matrix structural constituent", "id": "GO:0005201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005201", "evidence": [ { "database": "UniProtKB", "id": "F1MLA7", "url": "https://www.uniprot.org/uniprotkb/F1MLA7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 122, "end_pos": 124, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1349, "end_pos": 1351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 153, "end_pos": 155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1647, "end_pos": 1649, "annotation": "n_glycosylation_sequon" }, { 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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"database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24028:SF118", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24028:SF118", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00028", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00028", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF08266", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08266", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16492", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16492", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "XP_005209567", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005209567", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F1MLJ1", "url": "https://www.uniprot.org/uniprotkb/F1MLJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLJ1-1", "url": 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"tr|F1MLJ1-1|F1MLJ1_BOVIN Isoform 1 of Protocadherin beta-1 OS=Bos taurus OX=9913 GN=PCDHB1 PE=4 SV=2 CANONICAL=F1MLJ1-1" }, "isoforms": [ { "isoform_ac": "F1MLJ1-1", "url": "https://www.uniprot.org/uniprotkb/F1MLJ1/entry", "sequence": { "sequence": "MATACRKLLQSRQVETLLLFLCLSVGGAATIRYSVAEEMESGSFVANVAKDLGLEVGKLAARGARLVSEGNKLHFRLHRKTGDLFVKEKLDRESLCGKADPCVLHFEVVLVEPLQSFRVEVRVFDINDNAPVFLNKEPLLRIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSANEYFHLHTRFRSNGPKYAELVLDKPLDREEQPEVNMTITAVDGGSPPKSGTAHIRVEVLDVNDHVPQFSRLVYRAQVPENSANGSLVATVTATDLDEGSNKEITYSLAQNPEVILQTFQIHSETGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLVEVVDVNDNPPEVTVSSVSSPLPEDSPLQTVVALFSIRDRDIRVGGKITCFLKEDLPFAVKPTFRNSYSLVTDRGLDREAVSGYNITLVAMDTGPPTLSSETVIEVLISDINDNPPVFQEDSYILTVRENNSPAVFIGKVLAEDLDLGENAKVTYSLLPPKSGDLSVFAYISINSDNGKLYALRTMDYEAIQHFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNGTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLFKATDLGLFSVQQQNGEIRTLRQVSERDPTMQKLVILVQDHGQPALSTTASLNILLVDGFSEPYLQFRDTFKHPTRVNPSTKYLVISLAVLSFLFLLSVTVIFIIHICQKIKHREKFTIQEHFYDDCNFSNNLVQGGASGPILQPCPYEMCSATGTSNSEFRFLKRFMPNFPFPHGNGEAKTEADSRLPPDSDRNRSRGSEGHAQVSDDYM", "length": 818, "header": "tr|F1MLJ1-1|F1MLJ1_BOVIN Isoform 1 of Protocadherin beta-1 OS=Bos taurus OX=9913 GN=PCDHB1 PE=4 SV=2 CANONICAL=F1MLJ1-1" }, "locus": { "chromosome": "7", "start_pos": 52172366, "end_pos": 52169913, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000052339.3", "url": "https://www.ensembl.org/id/ENSBTAT00000052339.3" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000049713.2", "url": "https://www.ensembl.org/id/ENSBTAP00000049713.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "bta:504206", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:504206", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F2Z3R5-1", "protein_name": "Protocadherin beta-1", "gene_name": "Pcdhb1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAARRKPLQNRQVGSLLLLWCVSVGGAATIRYSVAEEMESGSFVANVAKDLGLEVGKLAERGARLVAEGNRLHFRLHRKTGDLFVKEKLDREALCGKADPCVLHFEIILAEPLQSFRVEVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSANTYFHLHTRFRSHGPKYAELVLDNPLDREAQPEVNLTITAVDGGSPPKSGTANIRVVVLDVNDHVPQFSRLVYRAQVPENSDNGSLVVVVTATDLDEGTNKQITYSLAENPEAVLRTFLVDPQTGEVRLRGPLDFETIETYDIDIQATDGGGLSAHSKVLVEVVDVNDNPPEVTISSVSSPLAEDSPLQTVVALFTIRDRDVRVGGKITCFLKEDLPFVVKHTFRNSYSLVTDRILDREDVSNYNITLVAMDTGPPSLSTETVIEVVISDINDNSPVFQEDSYVLTVRENNSPAVFIGKVHAEDLDLGENAQVTYSLLPPKSGDLSVFAYISINSDNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNGTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNGEIRTLRQISERDPMMQKLVILVQDHGQPALSTTASLNILLVDGFSEPYLQFQDPSKHSRKVNPTTKYLVISLAVLSFLFLFSVTVIIIIHLYQKIKHREKFTVQEHFYDDCNFPNNLVQGRGNGSLSQPCPYDMCSATGTGNSEFRFLKRFMPNFPFPHATGEVKTENDASLPPDSNRNRSRGSEGHARAGDDYM", "length": 818 }, "evidence": [ { "id": "F1MLJ1", "url": "https://omabrowser.org/oma/group/F1MLJ1/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9Y5F3-1", "protein_name": "Protocadherin beta-1", "gene_name": "PCDHB1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGTRRKSLQNRQVGSLLIFLCISVGDATTIRYSVAEEMESGSFVANVAKDLGLEVGKLAARGARLVSEGNKMHFRLHRKTGDLFVKEKLDRESLCGKADPCVLHFEVVLVEPLQSFRAEVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVNDHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVLVEVVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLREDLPFVIKPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFREDSYILTVRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNGTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNGEIHTLRQISERDPMMQKLIILVQDHGQPALSTTVSLNILLVDGFSEPYLQFQDPTKHSRKVNPSTKYLVISLVILSFLFLLSVIVIFIIHVYQKIKYREKFTIQEHFYDDCNFSNNLVQGQGNGSLSRPCPYEMCSATGTGNSEFRFLKRFMPNFPFPHATGEIKMEAGSSLPPNSDRNKSQRLEGHDQVSDDYM", "length": 818 }, "evidence": [ { "id": "F1MLJ1", "url": "https://omabrowser.org/oma/group/F1MLJ1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ1", "url": "https://www.uniprot.org/uniprotkb/F1MLJ1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ1", "url": "https://www.uniprot.org/uniprotkb/F1MLJ1" } ], "pmid": "" }, { "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ1", "url": "https://www.uniprot.org/uniprotkb/F1MLJ1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ1", "url": "https://www.uniprot.org/uniprotkb/F1MLJ1" } ], "pmid": "" }, { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "F1MLJ1", "url": "https://www.uniprot.org/uniprotkb/F1MLJ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 169, "end_pos": 171, "annotation": "n_glycosylation_sequon" }, { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 257, "end_pos": 259, "annotation": "n_glycosylation_sequon" }, { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 464, "end_pos": 466, "annotation": "n_glycosylation_sequon" }, { "start_pos": 568, "end_pos": 570, "annotation": "n_glycosylation_sequon" }, { "start_pos": 735, "end_pos": 737, "annotation": "n_glycosylation_sequon" }, { "start_pos": 802, "end_pos": 804, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MLJ1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 818, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MLJ1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MLJ1" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MLJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLJ1" }, { "id": "PS50268", "database": "PROSITE", "url": "https://prosite.expasy.org/PS50268" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Cadherin", "eco_id": "ECO_0000259", "start_pos": 75, "end_pos": 133, "start_aa": "Phe", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 169, "end_pos": 171 }, { "start_pos": 209, "end_pos": 211 }, { "start_pos": 257, "end_pos": 259 }, { "start_pos": 419, "end_pos": 421 }, { "start_pos": 464, "end_pos": 466 }, { "start_pos": 568, "end_pos": 570 }, { "start_pos": 735, "end_pos": 737 }, { "start_pos": 802, "end_pos": 804 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MLL3-1", "uniprot_ac": "F1MLL3", "uniprot_id": "F1MLL3_BOVIN", "mass": { "chemical_mass": 37500.0, "monoisotopic_mass": 37500.0 }, "refseq": {}, "gene_names": [ { "name": "RASD1", "type": "recommended", "evidence": [ { "id": "F1MLL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLL3" } ] } ], "protein_names": [ { "name": "Ras related dexamethasone induced 1", "type": "synonym", "evidence": [ { "id": "F1MLL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLL3/entry#names_and_taxonomy" } ] } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MLL3", "url": "https://www.uniprot.org/uniprotkb/F1MLL3" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "RASD1", "url": "https://www.uniprot.org/uniprotkb/F1MLL3", "locus": { "chromosome": "19", "start_pos": 34821443, "end_pos": 34819142, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000020520", "url": "https://www.ensembl.org/id/ENSBTAG00000020520" } ] } } ], "crossref": [ { "id": "F1MLL3", "url": "https://alphafold.ebi.ac.uk/entry/F1MLL3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000020520", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000020520", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04143", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04143", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "F1MLL3", "url": "https://www.orthodb.org/?gene=F1MLL3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46149", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46149", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46149:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46149:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00071", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00071", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MLL3", "url": "https://www.uniprot.org/uniprotkb/F1MLL3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLL3-1", "url": "https://www.uniprot.org/uniprotkb/F1MLL3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLLFSEESAFQGKRARSPAEPKPELPAKPNSSLRPNHRLLVSRPRARPPRSLCSMKLSAMIKKMCPSDSELRIPAKNCYRMVVLGSSKVGKTAIVSRFLTGRFEDAYTPTIEDFHRKFYCIRGEIYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRDSFEEVRRLKRQILDTKSCLKNKTKENVDVPLVICGNKGDRDFHRQVEPRDIHQLVGTDPGRCAYFEISAKRNSSLDQMFHALFAMANLPREMSPDLHRRVSAQHCEALHQKALQGKRLRRAGGDRDDALGILAPWARRPSVHSDLMYIREKASGGSQAKDKERCVIS", "length": 330, "header": "tr|F1MLL3-1|F1MLL3_BOVIN Isoform 1 of Ras related dexamethasone induced 1 OS=Bos taurus OX=9913 GN=RASD1 PE=3 SV=2 CANONICAL=F1MLL3-1" }, "isoforms": [ { "isoform_ac": "F1MLL3-1", "url": "https://www.uniprot.org/uniprotkb/F1MLL3/entry", "sequence": { "sequence": 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"PF10373", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10373", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF10374", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10374", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "F1MLM3", "url": "https://www.uniprot.org/uniprotkb/F1MLM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLM3-1", "url": "https://www.uniprot.org/uniprotkb/F1MLM3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESSQVEALKARLLYQDVCRAAQCLDHFLLKGNAHEELFKPHVLALRDMVQQVCIKLMFLHPVEYGRKAEELLWRKTYSDVVLLLLKPNRKNTDSSEEQWEGPLWAHLKGGLRFYEHLFLFLQEHYQLGLWSYIDWPHSAIHFIGCKRAGPASEEEVDWARMACHRCLLYLGDLFRFQNEFLALHTKDLAERCYYRALSVAPHMGMPFNQLGTLTGSKYYGVEATYFYQRCLHSEVPFKGASWNLKQLYHHAGKRYSRLKRNQGKKLSLSQRRCWDNKRLLVSFLYLQSLLQPQRKFRATRLMALCQLVLEDFRLCLSYRPCPSNQSQASRERKPARGYQFLPDLLIFHMVVLCLMSVHSLRTAGSKQHRTAVTFTLTLFSHLIQHVTTRLQAELQKGKLTPEVDVPRDKEDQQKMEAGEGQQDGLAPSPGPRHSKSQKTHRSSHVSSEGDNPEASFHSCCDWDETEEDENTSLCSQVSSELSSETTYSDTTDDEESGSLNPQATQEGGAKSKDRIFPPRDKLKTCQLPSHLLGLLKTTSSASLSAPSSHKLPGKHGFHLAPVFSHSFFTPPSPASSKASVTEDDVSSCLETEPPAGCNLGQNASISQPCSNLQTIQKKLQVLSAEGLLPTVKVILGWLRANCSLLTAHGWSLFSLWDHLSMLLNLLPSVRDLQEPGLGLSYHLHELLQSCKGPHLPQFLKLPEDIALGQHWLKQASQERVGLEQDPPPLSSQDEAAVRVCFLRSFGHFATTLPGQFLRYDSHSGVFVSTGFEGPDNLSQQLLEKTSRIRFFKDIVQLWLQSEVVLLEKTLRHIQIRSALTLYLFPDPRALCEHLPVIRQLATSGQFLLIVPNIVVDILYILRREDKRASAAITFLEGELKRGNQYLLCQSCVSVTLVRPRMTRPDSDAWDLYNMLDICRGLLDSSWLGTPDHRNMITILTGICLDNPRNLSYPLQLVLGTATEAGVEVKNVLRFYRKWKMVS", "length": 983, "header": "tr|F1MLM3-1|F1MLM3_BOVIN Isoform 1 of Nonsense-mediated mRNA decay factor OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=F1MLM3-1" }, "isoforms": [ { "isoform_ac": "F1MLM3-1", "url": "https://www.uniprot.org/uniprotkb/F1MLM3/entry", "sequence": { "sequence": "MESSQVEALKARLLYQDVCRAAQCLDHFLLKGNAHEELFKPHVLALRDMVQQVCIKLMFLHPVEYGRKAEELLWRKTYSDVVLLLLKPNRKNTDSSEEQWEGPLWAHLKGGLRFYEHLFLFLQEHYQLGLWSYIDWPHSAIHFIGCKRAGPASEEEVDWARMACHRCLLYLGDLFRFQNEFLALHTKDLAERCYYRALSVAPHMGMPFNQLGTLTGSKYYGVEATYFYQRCLHSEVPFKGASWNLKQLYHHAGKRYSRLKRNQGKKLSLSQRRCWDNKRLLVSFLYLQSLLQPQRKFRATRLMALCQLVLEDFRLCLSYRPCPSNQSQASRERKPARGYQFLPDLLIFHMVVLCLMSVHSLRTAGSKQHRTAVTFTLTLFSHLIQHVTTRLQAELQKGKLTPEVDVPRDKEDQQKMEAGEGQQDGLAPSPGPRHSKSQKTHRSSHVSSEGDNPEASFHSCCDWDETEEDENTSLCSQVSSELSSETTYSDTTDDEESGSLNPQATQEGGAKSKDRIFPPRDKLKTCQLPSHLLGLLKTTSSASLSAPSSHKLPGKHGFHLAPVFSHSFFTPPSPASSKASVTEDDVSSCLETEPPAGCNLGQNASISQPCSNLQTIQKKLQVLSAEGLLPTVKVILGWLRANCSLLTAHGWSLFSLWDHLSMLLNLLPSVRDLQEPGLGLSYHLHELLQSCKGPHLPQFLKLPEDIALGQHWLKQASQERVGLEQDPPPLSSQDEAAVRVCFLRSFGHFATTLPGQFLRYDSHSGVFVSTGFEGPDNLSQQLLEKTSRIRFFKDIVQLWLQSEVVLLEKTLRHIQIRSALTLYLFPDPRALCEHLPVIRQLATSGQFLLIVPNIVVDILYILRREDKRASAAITFLEGELKRGNQYLLCQSCVSVTLVRPRMTRPDSDAWDLYNMLDICRGLLDSSWLGTPDHRNMITILTGICLDNPRNLSYPLQLVLGTATEAGVEVKNVLRFYRKWKMVS", "length": 983, "header": "tr|F1MLM3-1|F1MLM3_BOVIN Isoform 1 of Nonsense-mediated mRNA decay factor OS=Bos taurus OX=9913 GN= PE=4 SV=4 CANONICAL=F1MLM3-1" }, "locus": { "chromosome": "14", "start_pos": 54625866, "end_pos": 54622918, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000108205.1", "url": "https://www.ensembl.org/id/ENSBTAT00000108205.1" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000096147.1", "url": "https://www.ensembl.org/id/ENSBTAP00000096147.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "F1MLM3", "url": "https://www.uniprot.org/uniprotkb/F1MLM3" } ], "pmid": "" }, { "name": "telomerase holoenzyme complex", "id": "GO:0005697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005697", "evidence": [ { "database": "UniProtKB", "id": "F1MLM3", "url": "https://www.uniprot.org/uniprotkb/F1MLM3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "telomeric DNA binding", "id": "GO:0042162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042162", "evidence": [ { "database": "UniProtKB", "id": "F1MLM3", "url": "https://www.uniprot.org/uniprotkb/F1MLM3" } ], "pmid": "" }, { "name": "telomerase RNA binding", "id": "GO:0070034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070034", "evidence": [ { "database": "UniProtKB", "id": "F1MLM3", "url": "https://www.uniprot.org/uniprotkb/F1MLM3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "id": "GO:0000184", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000184", "evidence": [ { "database": "UniProtKB", "id": "F1MLM3", "url": "https://www.uniprot.org/uniprotkb/F1MLM3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" }, { "start_pos": 471, "end_pos": 473, "annotation": "n_glycosylation_sequon" }, { "start_pos": 603, "end_pos": 605, "annotation": "n_glycosylation_sequon" }, { "start_pos": 642, "end_pos": 644, "annotation": "n_glycosylation_sequon" }, { "start_pos": 777, "end_pos": 779, "annotation": "n_glycosylation_sequon" }, { "start_pos": 950, "end_pos": 952, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MLM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLM3" }, { "id": "PF10373", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10373" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "DNA/RNA-binding", "eco_id": "ECO_0000259", "start_pos": 190, "end_pos": 393, "start_aa": "Ala", "end_aa": "Ala", "glycosite_overlap": [] }, { "evidence": [ { "id": "F1MLM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLM3" }, { "id": "PF10374", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF10374" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Telomerase activating protein Est1-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 68, "end_pos": 181, "start_aa": "Lys", "end_aa": "Phe", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 325, "end_pos": 327 }, { "start_pos": 471, "end_pos": 473 }, { "start_pos": 603, "end_pos": 605 }, { "start_pos": 642, "end_pos": 644 }, { "start_pos": 777, "end_pos": 779 }, { "start_pos": 950, "end_pos": 952 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MLP7-1", "uniprot_ac": "F1MLP7", "uniprot_id": "F1MLP7_BOVIN", "mass": { "chemical_mass": 39352.0, "monoisotopic_mass": 39352.0 }, "refseq": {}, "gene_names": [ { "name": "SNRNP40", "type": "recommended", "evidence": [ { "id": "F1MLP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLP7" } ] } ], "protein_names": [ { "name": "U5 small nuclear ribonucleoprotein 40 kDa protein", "type": "recommended", "evidence": [ { "id": "F1MLP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLP7/entry#names_and_taxonomy" } ] }, { "name": "WD repeat-containing protein 57", "type": "synonym", "evidence": [ { "id": "F1MLP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLP7/entry#names_and_taxonomy" } ] } ], "function": [ { "annotation": "Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.", "evidence": [ { "database": "UniProtKB", "id": "F1MLP7", "url": "https://www.uniprot.org/uniprotkb/F1MLP7#function" }, { "database": "UniProtKB", "id": "ARBA00057342", "url": "https://www.uniprot.org/uniprotkb/ARBA00057342#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MLP7", "url": "https://www.uniprot.org/uniprotkb/F1MLP7" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "SNRNP40", "url": "https://www.uniprot.org/uniprotkb/F1MLP7", "locus": { "chromosome": "2", "start_pos": 122372981, "end_pos": 122347180, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSBTAG00000016817", "url": "https://www.ensembl.org/id/ENSBTAG00000016817" } ] } } ], "crossref": [ { "id": "F1MLP7", "url": "https://alphafold.ebi.ac.uk/entry/F1MLP7", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000016817", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000016817", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR052234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR052234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR056551", "url": "https://www.ebi.ac.uk/interpro/entry/IPR056551", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IWDIRPY", "url": "https://omabrowser.org/oma/group/IWDIRPY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MLP7", "url": "https://www.orthodb.org/?gene=F1MLP7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44006", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44006", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44006:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44006:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00400", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF23098", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23098", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "R-BTA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "R-BTA-72165", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "database": "Reactome", "categories": [ "Enzyme and Pathway" ] }, { "id": "F1MLP7", "url": "https://www.uniprot.org/uniprotkb/F1MLP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1MLP7-1", "url": "https://www.uniprot.org/uniprotkb/F1MLP7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIEQQKRKGPELPLVPVKRQRHELLLGAAGSGPGAGQQQAAPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRLYMGEIQ", "length": 358, "header": "tr|F1MLP7-1|F1MLP7_BOVIN Isoform 1 of U5 small nuclear ribonucleoprotein 40 kDa protein OS=Bos taurus OX=9913 GN=SNRNP40 PE=4 SV=1 CANONICAL=F1MLP7-1" }, "isoforms": [ { "isoform_ac": "F1MLP7-1", "url": "https://www.uniprot.org/uniprotkb/F1MLP7/entry", "sequence": { "sequence": "MIEQQKRKGPELPLVPVKRQRHELLLGAAGSGPGAGQQQAAPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRLYMGEIQ", "length": 358, "header": "tr|F1MLP7-1|F1MLP7_BOVIN Isoform 1 of U5 small nuclear ribonucleoprotein 40 kDa protein OS=Bos taurus OX=9913 GN=SNRNP40 PE=4 SV=1 CANONICAL=F1MLP7-1" }, "locus": { "chromosome": "2", "start_pos": 122372531, "end_pos": 122347210, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSBTAT00000022372.7", "url": "https://www.ensembl.org/id/ENSBTAT00000022372.7" }, { "database": "Ensembl Peptide", "id": "ENSBTAP00000022372.5", "url": "https://www.ensembl.org/id/ENSBTAP00000022372.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "R-BTA-72163", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" }, { "id": "R-BTA-72165", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-BTA-72165", "resource": "Reactome", "description": "mRNA Splicing - Minor Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480U2S8-1", "protein_name": "U5 small nuclear ribonucleoprotein 40 kDa protein", "gene_name": "SNRNP40", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MIEQQKRKGPELPLVPVKRQRHELLLGAAGSGPGAGQQQAAPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRLYMGEIQ", "length": 358 }, "evidence": [ { "id": "F1MLP7", "url": "https://omabrowser.org/oma/group/F1MLP7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "D4A944-1", "protein_name": "U5 small nuclear ribonucleoprotein 40 kDa protein", "gene_name": "Snrnp40", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLEIDWLLSSGSSGGRTQLKPIAQRLLQAARLLAAPRVVVAAMIEQQKRKGPELPLVPVKRPRHELLLGAAGSGPGAGQQQATPGALLQTGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWSVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIILSASSDKRLYMGEIQ", "length": 400 }, "evidence": [ { "id": "F1MLP7", "url": "https://omabrowser.org/oma/group/F1MLP7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O22826-1", "protein_name": "Transducin/WD40 repeat-like superfamily protein", "gene_name": "", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MEIMSRENETALSGPRPMEWSTVPHSASQGPGPNGKNRTSSLEAPIMLLSGHPSAVYTMKFNPAGTLIASGSHDREIFLWRVHGDCKNFMVLKGHKNAILDLHWTSDGSQIVSASPDKTVRAWDVETGKQIKKMAEHSSFVNSCCPTRRGPPLIISGSDDGTAKLWDMRQRGAIQTFPDKYQITAVSFSDAADKIFTGGVDNDVKVWDLRKGEATMTLEGHQDTITGMSLSPDGSYLLTNGMDNKLCVWDMRPYAPQNRCVKIFEGHQHNFEKNLLKCSWSPDGTKVTAGSSDRMVHIWDTTSRRTIYKLPGHTGSVNECVFHPTEPIIGSCSSDKNIYLGEI", "length": 343 }, "evidence": [ { "id": "F1MLP7", "url": "https://omabrowser.org/oma/group/F1MLP7/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q55AR8-1", "protein_name": "U5 small nuclear ribonucleoprotein 40 kDa protein", "gene_name": "snrnp40", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MENKRKQKDEIVLVNGSNDTTPNKKQKNELQVVSSGGGREIILGTERTSKLEHPIMQLIGHKGEIYSCKFNSYGTALASGGSDKEIFLWNVYGECINYSVLKGHKGTILELHWSTDSNEIYTACTDKSIGVWDSNKGELIKRIREHSGVVNSCCPARRGPPLVASGSDDRSARIFDTRSKGSTHLFQHKYPVTSVCFSDASDQLITGGIDNVIRVWDIRNQEDPLYTLASHQDTITSTSVSKDGAYLLSNSMDNSCKIWDIRPYAPPNRNIKTFNGAQNNFEKNLIKSSWSIDGRRIGCGSSDRQVYIWDTNTKQLQYCLPGHSGTVNEVTFHPNEPIIASCSSDKTIYLGEIKP", "length": 355 }, "evidence": [ { "id": "F1MLP7", "url": "https://omabrowser.org/oma/group/F1MLP7/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q6PE01-1", "protein_name": "U5 small nuclear ribonucleoprotein 40 kDa protein", "gene_name": "Snrnp40", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MIEQQKRKGPELPLVPVKRPRHELLLGAAGAGPGAGPQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAVQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRVLYKLPGHAGSINEVAFHPDEPIILSASSDKRLYMGEIQ", "length": 358 }, "evidence": [ { "id": "F1MLP7", "url": "https://omabrowser.org/oma/group/F1MLP7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96DI7-1", "protein_name": "U5 small nuclear ribonucleoprotein 40 kDa protein", "gene_name": "SNRNP40", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ", "length": 357 }, "evidence": [ { "id": "F1MLP7", "url": "https://omabrowser.org/oma/group/F1MLP7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VPL0-1", "protein_name": "U5 small nuclear ribonucleoprotein 40 kDa protein", "gene_name": "Dmel\\CG3436", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MGTKRPNNSVILAQEAKRSKNDLMAYTNRDKALLESGVRRTSNLQAPIMQLEGHEGEIFTAEFHPEGELLLSSGFDRQIYIWQVYEDCENVMAMSGHSGAVMEAHFTPDGSHIFTCSTDKTLAFWDIATGQRQRRFKGHGNFVNSVQGSRRGQQLLCSGSDDRTIKIWDARKKHAAHTLESPFQVTAVCFGDTGEQVISGGIDNEVKIWDIRKQAVLHHLRGHSDTITGMSLSPEGDFILTNAMDNTLRVWDVRPYAPGERCVKVFQGHQHNFEKNLLRCAWSPGSDKITSGSADRHVYIWDVNTRRILYKLPGHNGSVNAVDFSPKEPLILSGSSDKTLYLGEIDE", "length": 347 }, "evidence": [ { "id": "F1MLP7", "url": "https://omabrowser.org/oma/group/F1MLP7/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "RNA splicing, via transesterification reactions", "id": "GO:0000375", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000375", "evidence": [ { "database": "UniProtKB", "id": "F1MLP7", "url": "https://www.uniprot.org/uniprotkb/F1MLP7" } ], "pmid": "" }, { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "F1MLP7", "url": "https://www.uniprot.org/uniprotkb/F1MLP7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "F1MLP7", "url": "https://www.uniprot.org/uniprotkb/F1MLP7" } ], "pmid": "" }, { "name": "catalytic step 2 spliceosome", "id": "GO:0071013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013", "evidence": [ { "database": "UniProtKB", "id": "F1MLP7", "url": "https://www.uniprot.org/uniprotkb/F1MLP7" } ], "pmid": "" }, { "name": "U2-type catalytic step 2 spliceosome", "id": "GO:0071007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071007", "evidence": [ { "database": "UniProtKB", "id": "F1MLP7", "url": "https://www.uniprot.org/uniprotkb/F1MLP7" } ], "pmid": "" }, { "name": "U5 snRNP", "id": "GO:0005682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005682", "evidence": [ { "database": "UniProtKB", "id": "F1MLP7", "url": "https://www.uniprot.org/uniprotkb/F1MLP7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 78, "end_pos": 80, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-F1MLP7-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 358, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-F1MLP7-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/F1MLP7" } ], "lectin_list": [], "domain_list": [ { "evidence": [ { "id": "F1MLP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLP7" }, { "id": "PF23098", "database": "Pfam", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23098" } ], "ann_type": "Domain_Extent_Annotation", "uniprotkb_annotation": "Nucleolar protein 10-like N-terminal", "eco_id": "ECO_0000259", "start_pos": 115, "end_pos": 265, "start_aa": "Glu", "end_aa": "Val", "glycosite_overlap": [] } ], "binding_sites": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 203, "end_pos": 205 }, { "start_pos": 78, "end_pos": 80 } ] }, "class_list": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ], "tool_support": { "graph_view": "yes" } }, { "uniprot_canonical_ac": "F1MLQ1-1", "uniprot_ac": "F1MLQ1", "uniprot_id": "F1MLQ1_BOVIN", "mass": { "chemical_mass": 14213.0, "monoisotopic_mass": 14213.0 }, "refseq": { "ac": "XP_059733687", "name": "histone H2A type 1-B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733687" }, "gene_names": [ { "name": "LOC524236", "type": "recommended", "evidence": [ { "id": "F1MLQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLQ1" } ] }, { "name": "LOC524236", "type": "synonym", "evidence": [ { "id": "XP_059733687", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733687" } ] } ], "protein_names": [ { "name": "Histone H2A", "type": "recommended", "evidence": [ { "id": "F1MLQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MLQ1/entry#names_and_taxonomy" } ] }, { "name": "histone H2A type 1-B", "type": "synonym", "evidence": [ { "id": "XP_059733687", "database": "RefSeq", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733687" } ] } ], "function": [ { "annotation": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.", "evidence": [ { "database": "UniProtKB", "id": "F1MLQ1", "url": "https://www.uniprot.org/uniprotkb/F1MLQ1#function" }, { "database": "UniProtKB", "id": "ARBA00002001", "url": "https://www.uniprot.org/uniprotkb/ARBA00002001#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Bos taurus", "taxid": 9913, "evidence": [ { "database": "UniProtKB", "id": "F1MLQ1", "url": "https://www.uniprot.org/uniprotkb/F1MLQ1" } ], "common_name": "Bovine", "glygen_name": "Bovine", "reference_species": "Bos taurus [9913]" } ], "gene": [ { "name": "LOC524236", "url": "https://www.uniprot.org/uniprotkb/F1MLQ1", "locus": {} } ], "crossref": [ { "id": "F1MLQ1", "url": "https://alphafold.ebi.ac.uk/entry/F1MLQ1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSBTAG00000034949", "url": "https://bgee.org/?page=gene&gene_id=ENSBTAG00000034949", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00074", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00074", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "524236", "url": "https://www.ncbi.nlm.nih.gov/gene/524236", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002119", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002119", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007125", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007125", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032454", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032454", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032458", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032458", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "bta:524236", "url": "https://www.genome.jp/dbget-bin/www_bget?bta:524236", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RRNICHA", "url": "https://omabrowser.org/oma/group/RRNICHA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "F1MLQ1", "url": "https://www.orthodb.org/?gene=F1MLQ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23430", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23430", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00125", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00125", "database": "Pfam", "categories": [ "Protein Classification", "Other" ] }, { "id": "PF16211", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16211", 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